Lane Medical Library

search help »

Books by Subject

Molecular Biology

  • Molecular medicine 2005, MyiLibrary
    History of molecular medicine -- DNA, RNA, genes and chromosomes -- Mendelian genetic traits -- Complex genetic traits -- Genomics, proteomics, and bioinformatics -- Genetic and cellular therapies -- Reproduction and development -- Infectious diseases -- Forensic medicine and science -- Ethical, legal, and social issues.
  • Molecular medicine 2005, ScienceDirect
    History of molecular medicine -- DNA, RNA, genes and chromosomes -- Mendelian genetic traits -- Complex genetic traits -- Genomics, proteomics, and bioinformatics -- Genetic and cellular therapies -- Reproduction and development -- Infectious diseases -- Forensic medicine and science -- Ethical, legal, and social issues.
  • Molecular medicine. 4th ed. 2012, ScienceDirect
  • Genetic analysis of bacterial pathogenesis -- Genetic exchance in bacteria and the modular stucture of mobile DNA elements -- Genomics and the use of genomic tools to study pathogenic bacteria -- Pathogenicity islands and bacterial virulence -- Capsules -- Bacterial cell walls -- Mechanisms of bacterial adhesion and consequences of attachment -- Bacterial invasion into non-phagocytic cells -- Bacterial protein secretion mechanisms -- Toxins as host cell modulators -- Quorum sensing: coordinating group behavior through intercellular signals -- The role of sigma factors in regulating bacterial stress responses and pathogenesis -- Two-component regulatory systems -- Oxidative stress systems in bacteria: four model organisms -- Bacterial biowarfare agents.
  • Basics of molecular biology -- Molecular pathology methods -- Genetic counseling -- Pedigree analysis and risk assessment -- Bayesian analysis -- Developmental disabilities -- Neuromuscular diseases -- Molecular genetic testing for metabolic disorders -- Fibroblast growth factor receptor-related skeletal disorders -- Cystic fibrosis -- Deafness -- Coagulation disorders -- Hematologic disorders : hemochromatosis, hemoglobinopathies, and Rh incompatibility --Cardiovascular disease -- Neurodegenerative disorders -- Skin and connective tissue disorders -- Inherited breast cancer -- Familial adenomatous polyposis and Turcot and Peutz-Jeghers syndromes -- Hereditary nonpolyposis colorectal cancer -- Multiple endocrine neoplasia syndromes -- The neurofibromatoses -- TP53 mutation and Li-Fraumeni syndrome -- von Hippel-Lindau disease -- Breast cancer -- Urothelial carcinoma -- Sarcomas -- Gliomas --Molecular detection of occult tumor cells -- Microarray studies (Beyond histology) -- Acute myeloid leukemia -- Acute lymphoblastic leukemia -- B-cell lymphomas -- T-cell lymphomas -- Lymphoproliferations of immunodeficiency -- Myeloproliferative disorders and myelodysplastic syndromes -- Human immunodeficiency virus type 1 -- Hepatitis B and C viruses -- Viral infections in transplant patients -- Viral infections of the central nervous system --Sexually transmitted diseases -- Respiratory pathogens -- Bacterial pathogens -- Mycobacterial infections -- Forensic DNA typing -- Parentage and relationship testing -- Assessment of chimerism in the setting of allogenic hematopoietic cell transplantation -- Specimen identification through DNA analysis -- Molecular HLA typing -- Molecular pathology laboratory management -- From research to clinical practice.
  • The application of modern molecular genetic and biologic techniques to infectious disease epidemiology dramatically improves measurement of disease and putative risk factors increasing our ability to detect and track outbreaks, identify risk factors and detect new infectious agents. However, integration of these techniques into epidemiologic studies also poses new challenges in the design, conduct, and analysis. We examine these opportunities and methodologic challenges giving specific examples. The book will be written for the reader with limited understanding of genetics, biology and epidemiology. *Presents the key points of consideration when integrating molecular biology and epidemiology *Discusses how using molecular tools in epidemiologic research affects program design and conduct *Considers the ethical concerns that arise in molecular epidemiologic studies *Provides a context for understanding and interpreting scientific literature as a foundation for subsequent practical experience in the laboratory and in the field.
  • Molecular toxicology 2004, CRCnetBASE
  • "Written for chemists, physicists, molecular biologists, and students in related fields, this reference covers information presently available on the specific properties of metallic nanoparticles, and compares their properties with those related to nanoobjects formed by biological molecules. It also discloses details of formation and physic-chemical peculiarities of the DNA nanostructures and DNA-based nanoconstructions. Timely in publication, the reference contains more DNA physics and molecular biology than other published titles. Authors discuss how nucleic acid molecules and their complexes with chemical and biologically active compounds are of great interest in the development of various nanoscale systems and devices of practical importance"--Provided by publisher.
  • Methods and tools in molecular epidemiology -- Molecular typing of bacterial pathogens: a tool for the epidemiological study and control of infectious diseases -- Contribution of population genetics -- Molecular epidemiology and evolutionary genetics of infectious diseases -- Population genetics and molecular epidemiology of infectious diseases -- Contribution of population and evolutionary epidemiology -- Modelling the dynamics of host-parasite interactions: basic principles -- Evolution of virulence: intuitions and models -- Case studies -- Molecular epidemiology of tuberculosis -- Pneumocystis molecular phylogeny: a way to understand both pneumocystosis natural histry and host taxonomy -- Hantavirus genetic diversity -- New integrations -- Nasal carriage of methicillin-resistant coagulase-negative staphylocococci: a reservoir of mecA gene for Staphylococcus aureus -- Molecular knowledge of mechanisms of helminth resistance: importance for diagnostic and epidemiology -- Molecular epidemiology of disease resistance genes with perspectives for researches on biological invasions and hybrid zones -- How does biodiversity influence the ecology of infectious disease? -- Epidemiological interaction at the wildlife/livestock/human interface: can we anticipate emerging infectious diseases in their hotspots? A framework for understanding emerging diseases processes in their hot spots.
  • Nitric oxide 2011, Springer Protocols
    Nitric oxide physiology and pathology / David G. Hirst and Tracy Robson -- Ionizing radiation-induced DNA strand breaks and [gamma]-H2AX foci in cells exposed to nitric oxide / Kai Rothkamm and Susanne Burdak-Rothkamm -- Determination of S-nitrosothiols in biological fluids by chemiluminescence / Enika Nagababu and Joseph M. Rifkind -- Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay / Barbora Piknova and Alan N. Schechter -- Selective fluorescent activation for bioimaging the expression of nitric oxide in cellular and in vivo systems / Junfeng Zhang and Hao Hong -- Real-time measurement of murine hippocampus NO levels in response to cerebral ischemia/reperfusion / Xiaoxiang Zheng, Kezhou Liu, and Yong Yang -- Detection of low levels of nitric oxide using an electrochemical sensor / Yong Chool Boo ... [et al.] -- Determination of the scavenging capacity against reactive nitrogen species by automatic flow injection-based methodologies / Marcela A. Segundo ... [et al.] -- Aqueous measurement of nitric oxide using membrane inlet mass spectrometry / David N. Silverman and Chingkuang Tu -- Quantum cascade laser technology for the ultrasensitive detection of low-level nitric oxide / Angela Elia ... [et al.] -- Determination of in vivo nitric oxide levels in animal tissues using a novel spin trapping technology / Anatoly F. Vanin and Alexander A. Timoshin -- [Beta] cell protection by inhibition of iNOS through lentiviral vector-based strategies / Sean O. Hynes, Cillian McCabe, and Timothy O'Brien -- Characterization of nitric oxide delivery systems produced by various nanotechnologies / Chi H. Lee -- Nitric oxide releasing nanoparticle synthesis and characterization / George Han, Adam J. Friedman, and Joel M. Friedman -- NOS antagonism using viral vectors as an experimental strategy : implications for in vivo studies of cardiovascular control and peripheral neuropathies / Beihui Liu ... [et al.]
  • Nitric oxide protocols. 2nd ed. 2004, Springer Protocols
    Measurement of nitric oxide by reconversion of nitrate/nitrite to NO / Reinhard Berkels, Svenja Purol-Schnabel, and Renate Roesen -- High-resolution capillary electrophoresis of nitrite and nitrate in biological samples / Dmitri Y. Boudko -- Nitrite and nitrate measurements in human urine by capillary electrophoresis / Edward Morcos and N. Peter Wiklund -- In vivo nitric oxide measurements using a microaxial electrode / Yoshiichiro Kitamura ... [et al.] -- Measurement of exhaled nitric oxide / Peter A. Steerenberg and Jan G.C. van Amsterdam -- Nitric oxide imaging in neurons using confocal microscopy / Xiaoxiang Zheng ... [et al.] -- Measurement of nitric oxide synthase activity in vivo and in vitro by gas chromatography-mass spectrometry / Dimitrios Tsikas -- A nonradioactive assay for nitric oxide synthase activity in tissue extracts / Hazel Sutherland ... [et al.] -- Measurement of nitric oxide-related enzymes in the brain by in situ hybridization / Olivier Braissant -- Real-time polymerase chain reaction to quantify mRNA for endothelial nitric oxide synthase / Yi Chu and Frank M. Faraci --Dioxygen-dependent metabolism of nitric oxide / Paul R. Gardner, Anne M. Gardner, and Craig K. Hallstrom -- Proteomic method for identification of tyrosine-nitrated proteins / Kulwant S. Aulak ... [et al.] -- Immunohistochemical detection of S-nitrosylated proteins / Andrew J. Gow ... [et al.] -- Gene therapy techniques for the delivery of endothelial nitric oxide synthase to the corpora cavernosa for erectile dysfunction / Trinity J. Bivalacqua ... [et al.] -- Adenovirus-mediated nitric oxide synthase gene transfer into the nucleus tractus solitarius in conscious rats / Yoshitaka Hirooka and Koji Sakai -- Gene therapy in cancer via use of a retrovector having a tumor specificity and expressing inducible nitric oxide synthase / Masahide Kuroki -- Gene transfer of nitric oxide synthase via the use of adeno-associated virus vectors / Yoshikazu Maeda, Kazuyuki Shimada, and Uichi Ikeda -- Adenovirus-mediated nitric oxide synthase gene transfer / Kathleen G. Raman ... [et al.].
  • Normal mode analysis 2006, CRCnetBASE
  • Nuclear dynamics 2007, Springer
  • Nuclear organization and function 2010, Cold Spring Harb Lab Press
    Chromatin modifications and gene expressions -- Transcription and beyond -- DNA replication and genome integrity -- Reprogramming and differentiation -- Heterochromatin formation and gene silencing -- Nuclear bodies and RNA biology -- Chromosome structure and mitosis -- Chromatin structure and organization -- Nuclear periphery.
  • Oligonucleotide synthesis 2004, Springer Protocols
    Synthesis of DNA using a new two-step cycle / Douglas J. Dellinger ... [et al.] -- RNA synthesis using 2'-O-(tert-butyldimethylsilyl) protection / Brian S. Sproat -- RNA oligonucleotide synthesis via 5'-silyl-2'-orthoester chemistry / Stephanie A. Hartsel... [et al.] -- Dimethylthiarum disulfide: new sulfur transfer reagent in phosphorothioates oligonucleotide synthesis -- Zhiwei Wang, Quanlai Song, and Yogesh H. Sanghvi -- Assay for evaluating ribonuclease H-mediated degradation of RNA-antisense oligonucleotide duplexes / Annie Galarneau ... [et al.] -- Di- and oligonucleotide synthesis using H-phosphonate chemistry / Jacek Stawinski and Roger Strömberg -- Solid-phase synthesis of circular oligonucleotides / Enrique Pedroso ... [et al.] -- Locked nucleic acid synthesis / Henrik M. Pfundheller ... [et al.] -- Synthesis of DNA mimics representing HypNA-pPNA hetero-oligomers / Vladimir A. Efimov and Oksana G. Chakhmakhcheva -- Base-modified oligonucleotides with increased duplex stability: pyrazolo[3,4-d] pyrimidines replacing purines / Frank Seela ... [et al.] --Introduction of hypermodified nucleotides in RNA / Darrell R. Davis and Ashok C. Bajji -- Chemical methods for peptide-oligonucleotide conjugate synthesis / Dmitry A. Stetsenko and Michael J. Gait -- Biotin labeled oligonucleotides with extraordinarily long tethering arms / A. Michael Morocho ... [et al.] -- Universal labeling chemistry for nucleic acid detection on DNA chips / Ali Laayoun ... [et al.] -- Postsynthetic functionalization of triple helix-forming oligonucleotides / Alexandre S. Boutorine and Jian-Sheng Sun -- Fluorescence-based on-line detection as an analytical tool in RNA electrophoresis / Ute Scheffer and Michael Göbel -- Design and optimization of molecular beacon real-time polymerase chain reaction assays / Jacqueline A. M. Vet and Salvatore A. E. Marras -- High-thoughput production of optimized primers (fimers) for whole-genome direct sequencing / Nikolai Polushin ... [et al.] -- Nonenzymatic template directed RNA synthesis / Marcus Hey and Michael Göbel -- DNAse I footprinting of small molecule binding sites on DNA / Christian Bailly ... [et al.] --Gene targeting using peptide nucleic acid / Peter E. Nielsen -- Nucleic acid library construction using synthetic DNA constructs / Hani S. Zaher and Peter J. Unrau -- In vitro selection from combinatorial nucleic acid libraries / Andres Jäschke -- In vitro selection procedures for identifying DNA and RNA aptamers targeted to nucleic acids and proteins / Eric Dausse ... [et al.] -- Short double-stranded ribonucleic acid as inhibitor of gene expression by the interference mechanism / Jean-Rémi Bertrand, Andrei Maksimenko, and Claude Malvy.
  • Ch. 1. Molecular biology of Omega-3 chains as structural lipids : many central questions remain unanswered -- Ch. 2. Darwinian selection of the fittest membrane lipids : from archaeal isoprenoids to DHA-enriched rhodopsin disks -- Ch. 3. Coevolution of DHA membranes and their proteins -- Ch. 4. Convergent evolution of DHA/EPA biosynthetic pathways -- Ch. 5. Membrane evolution in a marine bacterium : capitalizing on DHA for energy conservation in seawater -- Ch. 6. Evolution of DHA membranes in human neutrons -- Ch. 7. DHA/EPA chains as powerful membrane antifreeze -- Ch. 8. DHA as a mediocre permeability barrier against cations : water wire theory -- Ch. 9. DHA/EPA membranes as targets of oxidative damage -- Ch. 10. Bacteria : environmental modulation of membrane lipids for bioenergetic gain -- Ch. 11. Chloroplasts : harnessing DHA/EPA for harvesting light in the sea -- Ch. 12. Mitochondria : DHA-cardiolipin boosts energy output -- Ch. 13. Sperm : essential roles of DHA lead to development of a mechanical stress hypothesis -- Ch. 14. DHA/EPA mutualism between bacteria and marine animals -- Ch. 15. Membrane adaptations for an oily environment : lessons from a petroleum-degrading bacterium -- Ch. 16. Lessons from yeast : phospholipid conformations are important in winemaking -- Ch. 17. DHA principle applied to global warming -- Ch. 18. DHA principle applied to molecular farming -- Ch. 19. DHA/unsaturation theory of aging -- Ch. 20. DHA principle applied to neurodegenerative diseases -- Ch. 21. Dietary DHA in prevention of colon cancer : how a risk to the cell benefits the organism.
  • Organelle proteomics 2008, Springer Protocols
    Analysis of organelles by on-line two-dimensional liquid chromatography-tandem mass spectrometry / Edwin P. Romijn and John R. Yates III -- Purification and proteomic analysis of chloroplasts and their sub-organellar compartments / Daniel Salvi ... [et al.] -- Proteomic analysis of the stacked golgi complex / Mark S. Lowenthal, Kathryn E. Howell, and Christine C. Wu -- Purification of Saccharomyces cerevisiae mitochondria by zone electrophoresis in a free flow device / Hans Zischka ... [et al.] -- Preparation of respiratory chain complexes from Saccharomyces cerevisiae wild-type and mutant mitochondria : activity measurement and subunit composition analysis / Claire Lemaire and Geneviève Dujardin -- Mitochondrial proteomics : analysis of a whole mitochondrial extract with two-dimensional electrophoresis / Thierry Rabilloud -- Purification and proteomic analysis of the mouse liver mitochondrial inner membrane / Sandrine Da Cruz and Jean-Claude Martinou -- Subcellular fractionation and proteomics of nuclear envelopes / Laurence Florens, Nadia Korfali, and Eric C. Schirmer -- Purification and proteomic analysis of a nuclear-insoluble protein fraction / Tsuneyoshi Horigome, Kazuhiro Furukawa, and Kohei Ishii -- Preparation methods of human metaphase chromosomes for their proteome analysis / Kiichi Fukui, Hideaki Takata, and Susumu Uchiyama -- Purification and proteomic analysis of plant plasma membranes / Erik Alexandersson ... [et al.] -- Protocol to enrich and analyze plasma membrane proteins from frozen tissues / Jacek R. Wiśniewski -- Proteomic characterization of membrane protein topology / Adele R. Blackler and Christine C. Wu -- Free flow isoelectric focusing : a method for the separation of both hydrophilic and hydrophobic proteins of rat liver peroxisomes / Markus Islinger and Gerhard Weber -- Use of gas-phase fractionation to increase protein identifications : application to the peroxisome / Jacob Kennedy and Eugene C. Yi -- Purification and proteomic analysis of lysosomal integral membrane proteins / Huiwen Zhang ... [et al.] -- Affinity purification of soluble lysosomal proteins for mass spectrometric identification / Sylvie Kieffer-Jaquinod ... [et al.] -- Purification and proteomic analysis of synaptic vesicles / Holly D. Cox and Charles M. Thompson -- Purification and proteomics analysis of pancreatic zymogen granule membranes / Xuequn Chen and Philip C. Andrews -- Isolation and proteomic analysis of chlamydomonas centrioles / Lani C. Keller and Wallace F. Marshall -- Purification and proteomic analysis of 20S proteasomes from human cells / Marie-Pierre Bousquet-Dubouch ... [et al.] -- Characterization of E. coli ribosomal particles : combined analysis of whole proteins by mass spectrometry and of proteolytic digests by liquid chromatography-tandem mass spectrometry / Isabelle Iost ... [et al.] -- Assessment of organelle purity using antibodies and specific assays : the example of the chloroplast envelope / Daniel Salvi ... [et al.] -- Identifying bona fide components of an organelle by isotope-coded labeling of subcellular fractions : an example in peroxisomes / Marcello Marelli, Alexey I. Nesvizhskii, and John D. Aitchison -- Determination of genuine residents of plant endomembrane organelles using isotope tagging and multivariate statistics / Kathryn S. Lilley and Tom P.J. Dunkley -- Quantitative proteomic analysis to profile dynamic changes in the spatial distribution of cellular proteins / Wei Yan, Daehee Hwang, and Ruedi Aebersold -- Use of transcriptomic data to support organelle proteomic analysis / Wallace F. Marshall.
  • A brief overview of molecular genetics -- An overview of information theory -- More on molecular genetics -- More on information theory -- An outline of error-correcting codes -- DNA is an ephemeral memory -- A toy living world -- Subsidiary hypothesis, nested system -- Soft codes -- Biological reality conforms to the hypotheses -- Identification of genomic codes.
  • p53 2011, Springer
    TP53 mutations in human cancers : selection versus mutagenesis / Magali Olivier, Audrey Petitjean, Claude Caron de Fromentel, and Pierre Hainaut -- Lessons on p53 from mouse models / Dadi Jiang and Laura D. Attardi -- TP63, TP73 : the guardian's elder brothers / Stephanie Courtois, Pierre Hainaut and Claude Caron de Fromentel -- The regulation of p53 protein function by phosphorylation / Nicola J. Maclaine and Theodore Hupp -- The p53-Mdm2 loop : a critical juncture of stress response / Yaara Levav-Cohen, Zehavit Goldberg, Osnat Alsheich Bartok, Valentina Zuckerman, Sue Haupt and Ygal Haupt -- Cooperation between MDM2 and MDMX in the regulation of p53 / Jeremy Blaydes -- Regulation and function of the original p53-inducible p21 gene / Jennifer A. Fraser -- p53 localization / Carl G. Maki -- Modes of p53 interactions with DNA in the chromatin context / Vladana Vukojevic, Tatiana Yakovleva, and Georgy Bakalkin -- p53's dilemma in transcription : analysis by microarrays / Karuppiah Kannan, Gideon Rechavi and David Givol -- Tumor viruses and p53 / Nobuo Horikoshi -- p53 and immunity / Vikram Narayan, Sarah E. Meek and Kathryn L. Ball.
  • PCR cloning protocols. 2nd ed. 2002, Springer Protocols
  • PCR mutation detection protocols 2002, Springer Protocols
  • Peptide research protocols 2002, Springer Protocols
  • Phosphodiesterase methods and protocols 2005, Springer Protocols
    Purification of PDE6 isozymes from mammalian retina / Dana C. Pentia ... [et al.] -- Cyclic guanosine 5'-monophosphate binding to the regulatory GAF domains of photoreceptor phosphodiesterase / Rick H. Cote -- Renaturation of the catalytic domain of PDE4A expressed in escherichia coli as inclusion bodies / Wito Richter, Thomas Hermsdorf, and Dietrich Dettmer -- Determining the subunit structure of phosphodiesterases using gel filtration and sucrose density gradient centrifugation / Wito Richter -- Crystallization of cyclic nucleotide phosphodiesterases / Hengming Ke, Qing Huai, and Robert X. Xu -- Generation of PDE4 knockout mice by gene targeting / S.-L. Catherine Jin, Anne M. Latour, and Marco Conti -- Immunoprecipitating PDE2 phosphorylated and inactivated by an associated protein kinase / J. Kelley Bentley -- Investigation of extracellular signal-regulated kinase 2 mitogen-actived protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases / Elaine V. Hills, Miles D. Houslay, and George S. Baillie --Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11 / James L. Weeks ... [et al.] -- Analysis of dimerization determinants of the PDE6 catalytic subunits / Khakim G. Muradov, Kimberley K. Boyd, and Nikolai O. Artemyev -- Interaction between catalytic and inhibitory subunits of PDE6 / Nikolai O. Artemyev -- Purification, reconstitution on lipid vesciles and assays of PDE6 and its activator G protein, transducin -- Theodore G. Wensel, Feng He, and Justine A. Malinski.Study of cyclic adenosine monophosphate microdomains in cells / Marco Mongillo ... [et al.] -- High-resolution measurements of cyclic adenosine monophosphate signals in 3D microdomains / Jeffrey W. Karpen and Thomas C. Rich -- Cygnets : in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP / Akira Honda ... [et al.] -- High-throughput screening of phosphodiesterase activity in living cells / Thomas C. Rich and Jeffrey W. Karpen -- Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts / Thèrése Keravis, Rima Thaseldar-Roumié, and Claire Lugnier -- Localization of the cyclic guanosine 3', 5'-monophosphate-hydrolysing phosphodiesterase type 9 in rat brain by nonradioactive in situ hybridization / Wilma C.G. Van Staveren and Marjanne Markerink-Van Ittersum -- Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells / Chen Yan -- Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B / Faiyaz Ahmad ... [et al.] -- Identification of promoter elements in the 5'-flanking region of the murine cyclic nucleotide phosphodiesterase 3B gene / Hanguan Liu ... [et al.] --
  • Photosynthesis research protocols 2004, Springer Protocols
    Assay of photoinhibition of photosystem II and protease activity / Yasusi Yamamoto ... [et al.] -- Thermoluminescence: a technique for probing photosystem II / Prafullachandra V. Sane -- Detection of free radicals and reactive oxygen species / Éva Hideg -- Stabilization of photosynthetic materials / Régis Rouillon, Pierre Euzet, and Robert Carpentier -- Determination of phosphoproteins in higher plant thylakoids / Eva-Mari Aro, Anne Rokka, and Alexander V. Vener -- Identifying photoprotection mutants in Arabidopsis thaliana / Jan Bart Rossel, Abby Cuttriss, and Barry J. Pogson -- A simple method for chloroplast transformation in Chlamydomonas reinhardtii / Velupillai M. Ramesh, Scott E. Bingham, and Andrew N. Webber -- The Construction of gene knockouts in the Cyanobacterium Synechocystis sp. PCC 6803 / Julian J. Eaton-Rye -- Gene inactivation in the cyanobacterium Synechococcus sp. PCC 7002 and the green sulfur bacterium Chlorobium tepidum using in vitro-made DNA constructs and natural transformation / Niels-Ulrik Frigaard, Yumiko Sakuragi, and Donald A. Bryant.Fractionation of thylakoid membranes into grana and stroma thylakoids / Juan Cuello and María José Quiles -- Isolation of photosystem I particles from spinach / Tetsuo Hiyama -- Rapid isolation and purification of photosystem I chlorophyll-binding protein from Chlamydomonas reinhardtii / Velupillai M. Ramesh and Andrew N. Webber -- Isolation of photosystem II-enriched membranes and the oxygen-evolving complex subunit proteins from higher plants / Yasusi Yamamoto, Shinsuke Sakuma, and Jian-Ren Shen -- Isolation of functional photosystem II core particles from the Cyanobacterium synechocystis sp. PCC 6803 / Dmitrii Vavilin -- Isolation of photosystem I reaction center preparation from spinach / Tetsuo Hiyama -- Isolation of photosystem II reaction center complexes from plants -- Michael Seibert, Inmaculada Yruela, and Rafael Picorel -- Isolation of photosystem I reaction center subunit polypeptides from spinach / Tetsuo Hiyama -- Purification and crystallization of the cytochrome b6f complex in oxygenic photosynthesis / Huamin Zhang and William A. Cramer -- Purification of plastocyanin and cytochrome C6 from plants, green algae, and cyanobacteria / José A. Navarro, Manuel Hervás, and Miguel A. De la Rosa --Preparation of native and recombinant light-harvesting chlorophyll-a/b complex / Wolfgang Rühle and Harald Paulsen -- Isolation and characterization of lamellar aggregates of LHCII and LHCII-lipid macro-assemblies with light-inducible structural transitions / Ilian Simidjiev, Zsuzsanna Vácrkonyi, and Gyozo Garab -- Separation, purification and characterization of polypeptide composition of subcomplexes of the main light-harvesting chlorophyll a/b-protein complex of photosystem II / Grzegorz Jackowski -- Isolation of CP43 and CP47 photosystem II proximal antenna complexes from plants / Rafael Picorel, Miguel Alfonso, and Michael Seibert -- The determination and quantification of photosynthetic pigments by reverse phase high-performance liquid chromatography, thin-layer chromatography, and spectroscopy / Tessa Pocock, Marianna Król, and Norman P. A. Huner -- Isolation and identification of chloroplast lipids / Norihiro Sato and Mikio Tsuzuki -- DNA adducts with chlorophyll and chlorophyllin as antimutagenic agents: synthesis, stability, and structural features / Heidar-Ali Tajmir-Riahi, Jean-Francois Neault, and Stravoula Diamantoglou -- Incorporation and analysis of LHCII in model systems / Wieslaw I. Gruszecki -- Photosystem II reconstitution into proteoliposomes: structure-function characterization / Mário Fragata -- Extraction of the functional manganese and calcium from photosystem II / Joel Freeman, Garth Hendry, and Tom Wydrzynski --
  • Phylogenomics 2008, Springer Protocols
    From gene-scale to genome-scale phylogenetics : the data flood in, but the challenges remain / Antonis Rokas and Stylianos Chatzimanolis -- Phylogenomic analysis of chromosome sorting and painting / Roscoe Stanyon and Gary Stone -- FISH for mapping single copy genes / Terje Raudsepp and Bhanu P. Chowdhary -- Construction of radiation hybrid panels / John E. Page and William J. Murphy -- Survey sequencing and radiation hybrid mapping to construct comparative maps / Christophe Hitte ... [et al.] -- Construction of high-resolution comparative maps in mammals using BAC-end sequences / Denis M. Larkin and Harris A. Lewin -- Amniote phylogenomics : testing evolutionary hypotheses with BAC library scanning and targeted clone analysis of large-scale sequences from reptiles / Andrew M. Shedlock, Daniel E. Janes, and Scott V. Edwards -- Comparative physical mapping : universal overgo hybridization probe design and BAC library hybridization / James W. Thomas -- Phylogenomic resources at the UCSC Genome Browser / Kate Rosenbloom ... [et al.] -- Computational tools for the analysis of rearrangements in mammalian genomes / Glenn Tesler and Guillaume Bourque -- Computational reconstruction of ancestral DNA sequences / Mathieu Blanchette ... [et al.] -- Sequencing and phylogenomic analysis of whole mitochondrial genomes of animals / Rafael Zardoya and Mónica Suárez -- Retroposons : genetic footrpints on the evolutionary paths of life / Hidenori Nishihara and Norihiro Okada -- LINE-1 elements : analysis by FISH and nucleotide sequences / Paul D. Waters ... [et al.] -- Identification of cryptic sex chromosomes and isolation of X- and Y-borne genes / Paul D. Waters ... [et al.]
  • pt. 1. Principles of biophysical inquiry -- pt. 2. Foundations -- pt. 3. Building a model of biomolecular structure -- pt. 4. Function and action biological state space -- pt. 5. Methods for the measuring structure and function -- pt. 6. Physical constants.
  • Part I. Overview of Chloride Transporters and Channels -- Part II. Current Methods for Studying Chloride Regulation -- Part III. From Cloning to Structure, Function and Regulation of Chloride Transporters and Channels -- Part IV. Cation-Chloride Cotransporters in Neural Function and Dysfunction -- Part V. Cation-Chloride Cotransport in Choroid Plexus and Blood-Brain Barrier.
  • Section I. Introduction of cancer biology and cancer genetics -- Section II. Molecular techniques -- Section III. Molecular tests and cancer management -- Section IV. Molecular diagnostics of common malignancies -- Section V. Molecular basis of cancer therapeutics -- Section VI. Personalized medicine and targeted therapy of cancer -- Section VII. Future of molecular diagnostics and personalized cancer medicine.
  • Prion protein protocols 2008, Springer Protocols
    Cell culture models to unravel prion protein function and aberrancies in prion diseases / Katarina Bedecs -- Investigation of PrPc metabolism and function in live cells : methods for studying individual cells and cell populations / Cathryn L. Haigh and David R. Brown -- Immunodetection of PrPsc using western and slot blotting techniques / Hanny Gyllberg and Kajsa Löfgren -- Assaying prions in cell culture : the standard scrapie cell assay (SSCA) and the scrapie cell assay in end point format (SCEPA) / Sukhvir P. Mahal ... [et al.] -- Generation of cell lines propagating infectious prions and the isolation and characterization of cell-derived exosomes / Laura J. Vella and Andrew F. Hill -- Neurotoxicity of prion peptides on cultured cerebellar neurons / Giuseppe D. Ciccotosto, Roberto Cappai, and Anthony R. White -- Understanding the nature of prion diseases using cell-free assays / Victoria A. Lawson -- Methods for conversion of prion protein into amyloid fibrils / Leonid Breydo, Natallia Makarava, and Ilia V. Baskakov -- Amplification of purified prions in vitro / Surachai Supattapone, Nathan R. Deleault, and Judy R. Rees -- Expression and purification of full-length recombinant PrP of high purity / Natallia Makarava and Ilia V. Baskakov -- Analysis of PrP conformation using circular dichroism / Sen Han and Andrew F. Hill -- Effect of copper on the de novo generation of prion protein expressed in Pichia pastoris / Carina Treiber -- Biophysical investigations of the prion protein using electron paramagnetic resonance / Simon C. Drew and Kevin J. Barnham -- Molecular diagnosis of human prion disease / Jonathan D.F. Wadsworth ... [et al.] -- Analysis of endogenous PrPc processing in neuronal and non-neuronal cell lines / Victoria Lewis and Steven J. Collins -- Molecular typing of PrPres in human sporadic CJD brain tissue / Victoria Lewis ... [et al.] -- Transgenic mouse models of prion diseases / Glenn C. Telling -- Quantitiative bioassay of surface-bound prion infectivity / Victoria A. Lawson.
  • Protein chromatography 2011, Springer Protocols
    A digest of protein purification -- Gel-filtration chromatography -- Immunoaffinity chromatography -- Avoiding proteolysis during protein chromatography -- Scale-up of protein purification : Downstream processing issues -- Phage display : A powerful technology for the generation of high specificity affinity reagents from alternative immune sources -- Engineering protein stability -- Microfluidics in protein chromatography -- Tagging recombinant proteins to enhance solubility and aid purification -- Storage and lyophilisation of pure proteins -- Differential precipitation and solubilization of proteins -- Ion-exchange chromatography : Basic principles and application to the partial purification of soluble mammalian prolyl oligopeptidase -- Protein quantitation and analysis of purity -- Purification of proteins fused to glutathione S-transferase -- Purification of proteins fused to maltose-binding protein -- Purification of proteins from baculovirus-infected insect cells -- Purification of poly-histidine-tagged proteins -- Immobilized metal affinity chromatography/reversed-phase enrichment of phosphopeptides and analysis by cid/etd tandem mass spectrometry -- Tag removal by site-specific cleavage of recombinant fusion proteins -- Purification of antibodies using affinity chromatography -- Optimized generation of high-affinity, high-specificity single-chain Fv antibodies from multiantigen immunized chickens -- Measuring protein-protein interactions using biacore -- Ultra-performance liquid chromatography-mass spectrometry of proteins -- Hydrophobic interaction chromatography -- Fast protein liquid chromatography -- Shotgun proteomics : A qualitative approach applying isoelectric focusing on immobilized pH gradient and LC-MS/MS -- Shotgun proteomics : A relative quantitative approach using off-gel electrophoresis and LC-MS/MS -- Clinical proteomics : Liquid chromatography-mass spectrometry purification systems -- Strategies for the purification of membrane proteins -- A multi-step chromatographic strategy to purify three fungal endo-[beta]-glucanases.
  • Protein design 2006, Springer Protocols
    Design of structural elementary motifs. Structure and stability of the [alpha]-helix: lessons for design / Neil Errington, Teuku Iqbalsyah, and Andrew J. Doig. De novo design of monomeric [beta]-hairpin and [beta]-sheet peptides / David Pantoja-Uceda, Clara M. Santiveri, and M. Angeles Jiménez. De novo proteins from binary-patterned combinatorial libraries / Luke H. Bradley, Peter P. Thumfort, and Michael H. Hecht. Non-protein amino acids in the design of secondary structure scaffolds / Radhakrishnan Mahalakshmi and Padmanabhan Balaram. Design and synthesis of [beta]-peptides with biological activity / Marc J. Koyack and Richard P. Cheng -- Design of entire proteins and protein complexes. Design of miniproteins by the transfer of active sites onto small-size scaffolds / Franc̦ois Stricher, Loïc Martin, and Claudio Vita. Consensus design as a tool for engineering repeat proteins / Tommi Kajander, Aitziber L. Cortajarena, and Lynne Regan. Multiple sequence alignment as a guideline for protein engineering strategies / Alan R. Davidson. Sequence search methods and scoring functions for the design of protein structures / Hocine Madaoui, Emmanuelle Becker, and Raphael Guerois. Prediction of protein-protein interaction based on structure / Gregorio Fernandez-Ballester and Luis Serrano. Electrostatic design of protein-protein association rates / Gideon Schreiber, Yossi Shaul, and Kay E. Gottschalk -- Design of amyloidogenic polypeptides and amyloid inhibitors. Peptide model systems for amyloid fiber formation: design strategies and validation methods / Alexandra Esteras-Chopo, María Teresa Pastor, and Manuela López de la Paz. Protein misfolding disorders and rational design of antimisfolding agents / Lisbell D. Estrada, June Yowtak, and Claudio Soto.
  • Protein engineering protocols 2006, Springer Protocols
  • Protein folding protocols 2006, Springer Protocols
  • Protein misfolding and celluar stress : an overview / Niels Gregersen and Peter Bross -- Protein aggregation diseases : toxicity of soluble prefibrillar aggregates and their clinical significance / Massimo Stefani -- Consequences of stress in the secretary pathway : the ER stress response and its role in the metabolic syndrome / Martin Schröder and Louise Sutcliffe -- What role does mitochondrial stress play in neurodegenerative diseases? / Alicia Mae Pickrell and Carlos Torres Moraes -- Autophagy in disease / Dalibor Mijaljica, Mark Prescott, and Rodney J. Devenish -- Mitophagy and mitoptosis in disease processes / Dalibor Mijaljica, Mark Prescott, and Rodney J. Devenish -- Cellular stress and protein misfolding during aging / Rajiv Vaid Basaiawmoit and Suresh I.S. Rattan -- Measuring consequences of protein misfolding and cellular stress using OMICS techniques / Peter Bross ... [et al.] -- Production of cells with targeted integration of gene variants of human ABC transporter for stable and regulated expression using the Flp recombinase system / Kanako Wakabayashi-Nakao ... [et al.] -- Stress response profile in human fribroblasts exposed to heat shock or oxidative stress / Christina Bak Pedersen and Niels Gregersen -- Examining ubiquitinated protein aggregates in tissue sections / Natalia A. Kaniuk and John H. Brumell -- Determination of proteasomal activities / Cristovao F. Lima and Suresh I.S. Rattan -- Measurement of autophagy in cells and tissues / Isei Tanida and Satoshi Waguri -- Transcription factor sequestration by polyglutamine proteins / Tomoyuki Yamanaka and Nobuyuki Nukina -- Biological membranes as protein aggregation matrices and targets of amyloid toxicity / Monica Bucciantini and Cristina Cecchi -- Measurement of mitochondrial ROS production / Anatoly A. Starkov -- In vivo detection of oxidized proteins : a practical approach to tissue-derived mitochondria / Francesca Maltecca and Giorgio Casari -- Measurement of oxidized/reduced glutathione ratio / Joshua B. Owen and D. Allan Butterfield -- Determination of altered mitochondria ultrastructure by electron microscopy / Shoichi Sasaki -- Assessing bad sub-cellular localization under conditions associated with prevention or promotion of mitochondrial permeability transition-dependent toxicity / Liana Cerioni and Orazio Cantoni -- A cellular viability assay to monitor drug toxicity / Jakob Hansen and Peter Bross -- Rescue of misfolded proteins and stabilization by small molecules / Raymond C. Stevens, javier Sancho, and Aurora Martinez.
  • Analysis of protein phosphatases / Shirish Shenolikar -- A brief introduction to the protein phosphatase families / Tomas Mustelin -- Small molecule inhibitors of Ser/thr protein phosphatases / Mark Swingle, Li Ni, and Richard E. Honkanen -- Synthesis and use of the protein phosphatase affinity matrices microcystin- and microcystin-biotin-sepharose / Greg Moorhead, Timothy A.J. Haystead, and Carol MacKintosh -- Utilizing protein phosphatase inhibitors to define PP2A as a regulator of ataxia-telangiectasia mutated (ATM) / Aaron A. Goodarzi ... [et al.] -- An automated, fluorescence-based method for continuous assay of PP2A activity / Adam M. Wegner ... [et al.] -- An in vivo assay to quantify stable protein phosphatase 2A (PP2A) heterotrimeric species / Matthew S. Gentry, Richard L. Hallberg, and David C. Pallas -- Mutagenesis and expression of the scaffolding Aa and Ab subunits of PP2A / Ralf Ruediger, Jin Zhou, and Gernot Walter -- Isolation and characterization of PP2A holoenzymes containing FLAG-tagged B subunits / Deanna G. Adams and Brian E. Wadzinski -- Purification of PP2A holoenzymes by sequential immunoprecipitation with anti-peptide antibodies / Gernot Walter, Jin Zhou, and Ralf Ruediger -- Purification of PP2Ac from bovine heart / Hue T. Tran ... [et al.] -- Visualization of intracellular PP1 targeting through transiently and stably expressed fluorescent protein fusions / Laura Trinkle-Mulcahy ... [et al.] -- Yeast two-hybrid screens to identify drosophila PP1-binding proteins / Daimark Bennett and Luke Alphey -- Identification of cellular protein phosphatase-1 regulators / David W. Roadcap, Matthew H. Brush, and Shirish Shenolikar --Assay for 3-way interaction of protein phosphatase-1 (Glc7) with regulatory subunits plus phosphatase inhibitor-2 / Masumi Eto and David L. Brautigan -- Phosphorylation of the protein phosphatase type 1 inhibitor protein, CPI-17, by protein kinase C / Michael P. Walsh ... [et al.] -- Purification of smooth muscle myosin phosphatase using a thiophosphorylated myosin light chain-affinity resin / Merideth Borman and Justin MacDonald -- Proteins interacting with saccharomyces cerevisiae type 1 protein phosphatase catalytic subunit identified by single-step affinity purification and mass spectrometry / Edmund P. Walsh ... [et al.] -- Expression of protein histidine phosphatase in Escherichia coli, purification, and determination of enzyme activity / Nicole Bäumer .. [et al.] -- The use of RNA interference to analyze protein phosphatase function in mammalian cells / Iain Fraser ... [et al.] -- Recognition of a PP2C interaction motif in several plant protein kinases / Niranjan Chakraborty, Ohta Masaru, and Jian-Kang Zhu -- The use of yeast genetic tools to define biological roles of novel protein phosphatases / Joaquín Ariño ... [et al.] -- Targeting of PP2C in budding yeast / Irene Ota and James Mapes -- Phosphatase targets in TOR signaling / Estela Jacinto -- Functional characterization of the small CTD phosphatases (SCPs) / Michele Yeo and Patrick S. Lin -- Genome-scale discovery and characterization of class-specific protein sequences / David Kerk -- Yeast substrate-trapping system for isolating substrates of protein tyrosine phosphatases / Masahide Fukada and Masaharu Noda.
  • An introduction to protein sequencing using tandem mass spectrometry --The primary structure of proteins and a historical overview of protein sequencing --Fundamental mass spectrometry --Collisionally induced dissociation of protonated peptide icons and the interpretation of product ion spectra --Basic polyacrylamide gel electrophoresis --The preparation of protein digests for mass spectrometric sequencing experiments --Mass spectrometric analysis of tryptic digests --Protein identification by database searching --Sequence analysis of novel proteins --The characterization of post-translationally modified proteins using tandem mass spectometry.
  • Protein structure prediction. 2nd ed. 2008, Springer Protocols
    A historical perspective of template-based protein structure prediction / Jun-tao Guo, Kyle Ellrott, and Ying Xu -- The assessment of methods for protein structure prediction / Anna Tramontaro ... [et al.] -- Aligning sequences to structures / Liam James McGuffin -- Protein structure prediction using threading / Jinbo Xu, Feng Jiao, and Libo Yu -- Algorithms for multiple protein structure alignment and structure-derived multiple sequence alignment / Maxim Shatsky, Ruth Nussinov, and Haim J. Wolfson -- Indexing protein structures using suffix trees / Feng Gao and Mohammed J. Zaki -- Hidden Markov models for prediction of protein features / Christopher Bystroff and Anders Krogh -- The pros and cons of predicting protein contact maps / Lisa Bartoli ... [et al.] -- Roadmap methods for protein folding / Mark Moll, David Schwarz, and Lydia E. Kavraki -- Scoring functions for de novo protein structure prediction revisited / Shing-Chung Ngan ... [et al.] -- Protein-protein docking : overview and performance analysis / Kevin Wiehe ... [et al.] -- Molecular dynamics simulations of protein folding / Angel E. Garcia.
  • Protein-ligand interactions 2005, Springer Protocols
  • Proteome analysis 2004, ScienceDirect
  • Quantum dots 2006, Springer Protocols
    Immunofluorescent labeling of proteins in cultured cells with quantum dot secondary antibody conjugates / Richard L. Ornberg and Hongjian Liu -- Immunohistochemical detection with quantum dots / Rizwan S. Akhtar ... [et al.] -- Quantum dots for multicolor clinical pathology and multispectral imaging / Johbu Itoh and Robert Yoshiyuki Osamura -- Light and electron microscopic localization of multiple proteins using quantum dots / Thomas J. Deerinck ... [et al.] -- Human metaphase chromosome fluorescence in situ hybridization using quantum dot conjugates / Joan H.M. Knoll -- Biotin-ligand complexes with streptavidin quantum dots for in vivo cell-labeling of membrane receptors / Diane S. Lidke ... [et al.] -- Single quantum dot tracking of membrane receptors / Cødric Bouzigues ... [et al.] -- Optical monitoring of single cells using quantum dots / Jyoti K. Jaiswal and Sanford M. Simon -- Peptide-mediated intracellular delivery of quantum dots / B. Christoffer Lagerholm -- High-content analysis in multiple cell lines using quantum dots / Paul G. Wylie --Measuring cell motility using quantum dot probes / Weiwei Gu ... [et al.] -- Quantum dots for in vivo molecular and cellular imaging / Xiaohu Gao, Leland W.K. Chung, and Shuming Nie -- Sentinel lymph node mapping with type II quantum dots / John V. Frangioni ... [et al.] -- Macrophage-mediated colocalization of quantum dots in experimental glioma / Osman Muhammad, Alexandra Popescu, and Steven A. Toms -- Applications of quantum dots to multicolor flow cytometry / Pratip K. Chattopadhyay and Mario Roederer -- Quantum dots in flow cytometry / Barnaby Abrams and Tim Dubrovsky -- Luminescent biocompatible quantum dots: a tool for immunosorbent assay design / Ellen R. Goldman ... [et al.] -- Fluorescence-based analysis of cellular protein lysate arrays using quantum dots / David H. Geho ... [et al.] -- Application of quantum dots to multicolor microarray experiments: four-color genotyping / George Karlin-Neumann ... [et al.].
  • Quorum sensing 2011, Springer Protocols
    Bioassays of quorum sensing compounds using Agrobacterium tumefaciens and Chromobacterium violaceum -- Detection of 2-alkyl-4-quinolones using biosensors -- FRET-based biosensors for the detection and quantification of AI-2 class of quorum sensing compounds -- Isolation of agr quorum sensing autoinducers -- Liquid chromatography/mass spectrometry for the detection and quantification of N-acyl-l-homoserine lactones and 4-hydroxy-2-alkylquinolines -- Detection of autoinducer (AI-2)-like activity in food samples -- Detection of bacterial signaling molecules in liquid or gaseous environments -- Determination of acyl homoserine lactone and tetramic acid concentrations in biological samples -- Luminescent reporters and their applications for the characterization of signals and signal-mimics that alter LasR-mediated quorum sensing -- Modulation of mammalian cell processes by bacterial quorum sensing molecules -- Imaging N-acyl homoserine lactone quorum sensing in vivo -- Defining the structure and function of acyl-homoserine lactone autoinducers -- Global expression analysis of quorum-sensing controlled genes -- Small RNA target genes and regulatory connections in the Vibrio cholerae quorum sensing system -- Quantifying pseudomonas aeruginosa quinolones and examining their interactions with lipids -- Linking quorum sensing regulation and biofilm formation by Candida albicans -- Design of synthetic mammalian quorum-sensing systems -- Qualitative and quantitative determination of quorum sensing inhibition in vitro -- Custom synthesis of autoinducers and their analogues -- Heterologous overexpression, purification, and in vitro characterization of ahl lactonases -- High-performance liquid chromatography analysis of N-acyl homoserine lactone hydrolysis by paraoxonases -- Generation of quorum quenching antibodies.
  • Receptor binding techniques. 2nd ed. 2005, Springer Protocols
    Receptor databases and computational websites for ligand binding -- Identification of orphan G protein-coupled receptor ligands using FLIPR assays -- Quantitative analysis of orphan G protein-coupled receptor mRNAs by TaqMan real-time PCR: G2A and GPR4 lysophospholipid receptor expression in leukocytes and in a rat myocardial infarction-heart failure model -- mRNA: detection by in situ and northern hybridization -- Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems -- Measurement of radioligand binding by scintillation proximity assay -- Autoradiography of enzymes, second messenger systems, and ion channels -- Immunocytochemical localization of receptors using light and confocal microscopy with application to the phenotypic characterization of knock-out mice -- Live cell imaging of G protein-coupled receptors --Imaging and characterization of radioligands for positron emission tomography using quantitative phosphor imaging autoradiography -- Dynamic in vivo imaging of receptors in small animals using positron emission tomography.
  • "Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Anibidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume."--Jacket.
  • Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm - in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillar.
  • Repetitive DNA 2012, Karger
    The Repetitive DNA Content of Eukaryotic Genomes / López-Flores, I.; Garrido-Ramos, M.A. -- Telomere Dynamics in Mammals / Silvestre, D.C.; Londoño-Vallejo, A. -- Drosophila Telomeres: an Example of Co-Evolution with Transposable Elements / Silva-Sousa, R.; López-Panadès, E.; Casacuberta, E. -- The Evolutionary Dynamics of Transposable Elements in Eukaryote Genomes / Tollis, M.; Boissinot, S. -- SINEs as Driving Forces in Genome Evolution / Schmitz, J. -- Unstable Microsatellite Repeats Facilitate Rapid Evolution of Coding and Regulatory Sequences / Jansen, A.; Gemayel, R.; Verstrepen, K.J. -- Satellite DNA Evolution / Plohl, M.; Meštrović, N.; Mravinac, B. -- Satellite DNA-Mediated Effects on Genome Regulation / Pezer, Ž.; Brajković, J.; Feliciello, I.; Ugarković, Đ. -- The Birth-and-Death Evolution of Multigene Families Revisited / Eirín-López, J.M.; Rebordinos, L.; Rooney, A.P.; Rozas, J. -- Chromosomal Distribution and Evolution of Repetitive DNAs in Fish / Cioffi, M.B.; Bertollo, L.A.C..
  • Ribonuclease P 2010, Springer
    History of RNase P and Overview of Its Catalytic Activity -- The Evolution of RNase P and Its RNA -- Over a Decade of Bacterial Ribonuclease P Modeling -- Structural Studies of Ribonuclease P -- Folding of Bacterial RNase P RNA -- Kinetic Mechanism of Bacterial RNase P -- Roles of Metal Ions in RNase P Catalysis -- Challenges in RNase P Substrate Recognition: Considering the Biological Context -- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives -- Eukaryote RNase P and RNase MRP -- RNase P from Organelles -- Human RNase P and Transcription -- RNase P as a Drug Target -- Ribonuclease P as a Tool.
  • RNA 2001, ScienceDirect
  • RNA 2008, Springer Protocols
    The transcriptional landscape -- Working with RNA -- Synthesis of RNA by in vitro transcription -- Efficient poly(A)+ RNA selection using LNA oligo(T) capture -- Genome browsers -- Web-based tools for studying RNA structure and function -- Northern blotting analysis -- Rapid amplification of cDNA ends (RACE) -- Fractionation of mRNA based on the length of the poly(A) tail -- Analysis of mutations that influence pre-mRNA splicing -- S1 nuclease analysis of alternatively spliced mRNA -- Promises and challenges in developing RNAi as a research tool and therapy -- Inhibition of gene function in mammalian cells using short-hairpin RNA (shRNA) -- Validation of RNAi by real time PCR -- Profiling RNA polymerase II using the fast chromatin immunoprecipitation method -- The post-transcriptional operon -- RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray (chip) profiling -- Isolation of RNP granules -- Electrophoretic mobility shift assay for characterizing RNA-protein interaction -- Polysome analysis and RNA purification from sucrose gradients -- Prediction of targets for microRNAs -- Outsourcing of experimental work.
  • Introduction /Michael Levitt --Modeling RNA Molecules /Neocles Leontis and Eric Westhof --Methods for Predicting RNA Secondary Structure /Kornelia Aigner, Fabian Dre€en and Gerhard Steger --Why Can't We Predict RNA Structure At Atomic Resolution? /Parin Sripakdeevong, Kyle Beauchamp and Rhiju Das --Template-Based and Template-Free Modeling of RNA 3D Structure: Inspirations from Protein Structure Modeling /Kristian Rother, Magdalena Rother, Michał Boniecki, Tomasz Puton and Konrad Tomala, et al. --The RNA Folding Problems: Different Levels of sRNA Structure Prediction /Fredrick Sijenyi, Pirro Saro, Zheng Ouyang, Kelly Damm-Ganamet and Marcus Wood, et al. --Computational Prediction and Modeling Aid in the Discovery of a Conformational Switch Controlling Replication and Translation in a Plus-Strand RNA Virus /Wojciech K. Kasprzak and Bruce A. Shapiro --Methods for Building and Refining 3D Models of RNA /Samuel C. Flores, Magdalena Jonikas, Christopher Bruns, Joy P. Ku and Jeanette Schmidt, et al. --Multiscale Modeling of RNA Structure and Dynamics /Feng Ding and Nikolay V. Dokholyan --Statistical Mechanical Modeling of RNA Folding: From Free Energy Landscape to Tertiary Structural Prediction /Song Cao and Shi-Jie Chen --Simulating Dynamics in RNA-Protein Complexes /John Eargle and Zaida Luthey-Schulten --Quantum Chemical Studies of Recurrent Interactions in RNA 3D Motifs /Jiří Šponer, Judit E. Šponer and Neocles B. Leontis --Nonredundant 3D Structure Datasets for RNA Knowledge Extraction and Benchmarking /Neocles B. Leontis and Craig L. Zirbel --Ions in Molecular Dynamics Simulations of RNA Systems /Pascal Auffinger --Modeling RNA Folding Pathways and Intermediates Using Time-Resolved Hydroxyl Radical Footprinting Data /Joshua S. Martin, Paul Mitiguy and Alain Laederach --A Top-Down Approach to Determining Global RNA Structures in Solution Using NMR and Small-Angle X-ray Scattering Measurements /Yun-Xing Wang, Jinbu Wang and Xiaobing Zuo --RNA Structure Determination by Structural Probing and Mass Spectrometry: MS3D /A. E. Hawkins and D. Fabris.
  • 1. RNA polymerases and transcription factors of trypanosomes / Arthur Günzl -- 2. SL RNA biogenesis in kinetoplastids: a long and winding road / Nancy R. Sturm, Jesse R. Zamudio, and David A. Campbell -- 3. Pre-mRNA splicing in trypanosoma brucei: factors, mechanisms, and regulation / Christian Preusser, Nicolas Jaé, Arthur Günzl, and Albrecht Bindereif -- 4. mRNA turnover in trypanosomes / Christine Clayton -- 5. tRNA biogenesis and processing / Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, and Juan D. Alfonzo -- 6. rRNA biogensis in trypanosomes / Shulamit Michaeli -- 7. RNA editing in African trypanosomes: a U-ser's G-U-ide / H. Ulrich Göringer -- 8. The RNA interference pathway in trypanosoma brucei / Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, and Christian Tschudi -- 9. Translation in trypanosomatids -- 10. Mitochondrial translation in trypanosomatids / Dmitri A. Maslov and Rajendra K. Agrawal -- 11. RNA-Seq analysis of the transcriptome of trypanosoma brucei / Jan Mani, Kapila Gunasekera, and Isabel Roditi.
  • The key features of RNA silencing / Kuniaki Saito ... [et al.] -- Selected strategies for the delivery of siRNA in vitro and in vivo / Sandra D. Laufer ... [et al.] -- RNAi suppression and its application / Xiaoping Yi, Rui Lu -- Strategies to prevent siRNA-triggered cellular toxicity / Matthias Bauer -- RNAi in malignant brain tumors: relevance to molecular and translational research / Mitsutoshi Nakada ... [et al.] -- Silencing Huntington's disease gene with RNAi / Yu Zhang, Robert M. Friedlander -- Application of Dicer-substrate siRNA in pain research / Philippe Sarret ... [et al.] -- RNAi treatment of HIV-1 infection / Karin J. von Eije, Ben Berkhout -- Application of RNA interference to treat conditions associated with dysregulation of transient receptor potential vanilloid 1 channel / Vickram Ramkumar ... [et al.] -- Harnessing RNAi-based functional genomics to unravel the molecular complexity underlying skin pigment variation / Hsiang Ho ... [et al.] --mRNA structure and its effects on posttranscriptional gene silencing / Stephen I. Rudnick, Veenu Aishwarya, Alan M. Gewirtz -- Antisense RNA-mediated regulation of the p53 tumor suppressor / Marianne Farnebo, Klas G. Wiman -- Antisense oligonucleotides: insights from preclinical studies and clinical trials / Doreen Kunze, Kai Kraemer, Susanne Fuessel -- What can the new hammerhead ribozyme structures teach us about design? / William G. Scott -- microRNA biogenesis and its impact on RNA interference / Stefanie Grund, Sven Diederichs -- MicroRNAs in epithelial antimicrobial immunity / Jun Liu ... [et al.] -- Emerging roles of long noncoding RNAs in gene expression and intracellular organization / Tetsuro Hirose -- Noncoding RNAs as therapeutic targets / Maciej Szymański, Jan Barciszewski -- Noncoding RNAs at H19/IGF2 locus: role in imprinting, gene expression, and associated pathologies / Nahalie Berteaux, Nathalie Spruyt, Eric Adriaenssens.
  • 1. Isolation of a sequence-specific RNA binding protein, polypyrimidine tract binding protein using RNA affinity chromatography / Shalini Sharma -- 2. An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase /Isabel Kurth, Gaël Cristofari, Joachim Lingner -- 3. RNA affinity tags for the rapid purification and investigation of RNAs and RNA-protein complexes / Scott C. Walker ... [et al.] -- 4. Assembly and glycerol gradient isolation of yeast spliceosomes containing transcribed or synthetic U6 SnRNA / Ken Dery, Shyue-Lee Yean, Ren-Jang Lin -- 5. Purification of ribonucleoproteins using peptide-elutable antibodies and other affinity techniques / Scott Stevens -- 6. CLIP: cross-linking and immunoprecipitation of in vivo RNA targets of RNA binding proteins / Kirk B Jensen, Robert B. Darnell -- 7. Quantitative analysis of protein-RNA interactions by gel mobility shift / Sean P. Ryder, Michael I. Recht, James R. Williamson -- 8. Monitoring assembly of ribonucleoprotein complexes by isothermal titration calorimetry / Michael I. Recht, Sean P. Ryder, James R. Williamson -- 9. Characterization of RNA-protein interactions by phosphorothioate footprinting and its applications to the ribosome / A. Ozlem Tastan Bishop, ... [et al.] -- 10. In vivo analysis of ribonucleoprotein complexes using nucleotide analog interference mapping / Lara Weinstein Szewczak -- 11. T7 RNA polymerase mediated incorporation of 8-N3AMP into RNA for studying protein-RNA interactions / Rajesh Gaur -- 12. A simple crosslinking method, CLAMP, to map the sites of RNA contacting domains within a protein / Hiren Banerjee, Ravinder Singh -- 13. Proteins specifically modified with a chemical nuclease as probes of RNA-protein interaction / Oliver A. Ken, Andrew M. MacMillan -- 14. RNA-protein crosslink mapping using TEV protease / Ian A. Turner, ... [et al.] -- 15 Structural analysis of protein-RNA interactions with mass spectrometry / Mamuka Kvaratskhelia, Stuart F.J. Le Grice -- 16. Analysing RNA-protein cross-linking sites in unlabeled ribonucleoprotein complexes by mass spectrometry / Henning Urlaub, Eva Kühn-Hölsken, Reinhard Lührmann --17. In vitro selection of random RNA fragments to identify protein binding sites within large RNAs / Ulrich Stelzl, Knud H. Nierhaus -- 18. Immunoprecipitation analysis to study RNA-protein interactions in xenopus oocytes / Naoto Mabuchi, Kaoru Masuyama, Mutsuhito Ohno -- 19. Mapping the regions of RNase P catalytic RNA that are potentially in close contact with its protein cofactor / Phong Trang, Fenyong Liu -- 20. Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay / Peggy S. Eis, Mariano Garcia-Blanco -- 21. Analysis of RNA structure and RNA-protein interactions in mammalian cells by use of terminal transferase-dependent PCR / Hsiu-Hua Chen, Jeanne LeBon, Arthur D. Riggs -- 22. Duplex unwinding and RNP remodeling with RNA helicases / Eckhard Jankowsky, Margaret E. Fairman -- 23. Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions / Naoyuki Kataoka, Gideon Dreyfuss -- 24. Designing and utilization of siRNAs targeting RNA-binding proteins / Dong-Ho Kim, Mark Behlke, John J. Rossi -- 25. The use of saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins / Jane E. Jackman, Eric M. Phizicky.
  • RNAi 2008, Springer Protocols
  • RT-PCR protocols 2002, Springer Protocols
  • Selenium. 3rd ed. 2012, Springer
  • Applications of pressure cycling technology (PCT) in proteomics / Feng Tao ... [et al.] -- Applications of ion-exchange (IEX) chromatography to reduce sample complexity prior to two-dimensional gel electrophoresis (2DE) / Malcolm G. Pluskal, Eva Golenko, and Mary F. Lopez -- Separations in proteomics: use of camelid antibody fragments in the depletion and enrichment of human plasma proteins for proteomics applications / Mark ten Haaft, Pim Hermans, and Bruce Dawson -- Novel plasma protein separation strategy using multiple avian IgY antibodies for proteomic analysis / Sun W. Tam ... [et al.] -- Immunoaffinity depletion of high-abundant proteins for proteomic sample preparation / Nina Zolotarjova ... [et al.] -- Isolation of plasma membrane proteins for proteomic analysis / Catherine Fenselau and Amir Rahbar -- New ultrafiltration and solid phase extraction techniques improve serum peptide detection / Elena Chernokalskaya ... [et al.] -- Tools for sample preparation and prefractionation in two-dimensional (2D) gel electrophoresis / Anton Posch, Aran Paulus, and Mary Grace Brubacher -- Optic nerve fractionation for proteomics / Sanjoy K. Bhattacharya ... [et al.] -- Fractionation of retina for proteomic analyses / Sanjoy K. Bhattacharya ... [et al.] -- Reducing protein sample complexity with free flow electrophoresis (FFE) / Askar Kuchumov, Gerhard Weber, Christoph Eckerskorn --Destreaking strategies for two-dimensional electrophoresis / Fengju Bai, Sheng Liu, and Frank A. Witzmann -- Proteomic approaches to the study of rheumatoid arthritis / Mikaela Antonovici ... [et al.] -- Immunoglobulin patterns in health and disease / Ingrid Miller and Marcia Goldfarb -- Difference gel electrophoresis (DIGE) / Mustafa Unlu and Jonathan Minden -- Principles and challenges of basic protein separation by two-dimensional (2D) electrophoresis / Anton Posch, Aran Paulus, and Mary Grace Brubacher -- Multidimensional separation of membrane proteins / Susan Francis-McIntyre and Simon J. Gaskell -- Structural approaches to glycoproteomics / Heidi Geiser, Cristina Silvescu, and Vernon Reinhold -- Enrichment and analysis of glycoproteins in the proteome / Nicole L. Wilson, Niclas G. Karlsson, and Nicolle H. Packer -- Proteomic analyses using high-efficiency separations and accurate mass measurements / Jon M. Jacobs and Richard D. Smith -- Middle-out proteomics: incorporating multidimensional protein fractionation and intact protein mass analysis as elements of a proteomic workflow / Scott J. Berger ... [et al.] -- Polymeric monolithic capillary columns in proteomics / Alexander R. Ivanov -- Proteins staining in polyacrylamide gels / Gary B. Smejkal -- Multiplexed proteomics: fluorescent detection of proteins, glycoproteins, and phosphoproteins in two-dimensional (2D) gels / Birte Aggeler-Schulenberg -- Glyoxyl agarose and its composite gels: advantageous alternatives to polyacrylamide gel electrophoresis for very large and small proteins and peptides and all sizes in between / John R. Shainoff -- Nuclear magnetic resonance-driven chemical proteomics: the functional and mechanistic complement to proteomics / Phani Kumar Pullela and Daniel S. Sem -- Electrophoretic nuclear magnetic resonance in proteomics: toward high-throughput structural characterization of biological signaling processes / Qiuhong He and Xiangjin Song.
  • Single molecule biology 2009, ScienceDirect
    The "single molecule" paradigm / Alex E. Knight -- Single molecule studies of myosins / Rachel E. Farrow ... [et al.] -- Single molecule experiments and the kinesin motor protein superfamily : walking hand in hand / Lukas C. Kapitein and Erwin J.G. Peterman -- Force-generating mechanisms of dynein revealed through single molecule studies / Kazuhiro Oiwa and Hiroaki Kojima -- The bacterial flagellar motor / Yoshiyuki Sowa and Richard M. Berry -- Single molecule studies of chromatin structure and dynamics / Sanford H. Leuba and Laurence R. Brewer -- Single molecule studies of nucleic acid enzymes / Samir M. Hamdan and Antoine M. van Oijen -- Single molecule studies of prokaryotic translation / Colin Echeverría Aitken ... [et al.] -- Single ion channels / David Colquhoun, Remigijus Lape, and Lucia Sivilotti -- Single molecule fluorescence in membrane biology / Lydia M. Harriss and Mark I. Wallace -- Single molecule microarray analysis / Jan Hesse ... [et al.].
  • Star polymer surface passivation for single-molecule detection / Jürgen Groll and Martin Moeller -- Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation: phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy / Anirban Chakraborty ... [et al.] -- Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast / John Abelson, Haralambos Hadjivassiliou and Christine Guthrie -- Nanovesicle trapping for studying weak protein interactions by single-molecule FRET / Jaime J. Benítez, Aaron M. Keller and Peng Chen -- Droplet confinement and fluorescence measurement of single molecules / Lori S. Goldner, Ana M. Jofre and Jianyong Tang -- Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs / Abhinav Nath ... [et al.] -- Single-molecule spectroscopy using microfluidic platforms / Samuel Kim and Richard N. Zare -- Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning / Julian Weghuber ... [et al.] -- Analysis of complex single-molecule FRET time trajectories / Mario Blanco and Nils G. Walter -- Single-molecule fluorescence studies of intrinsically disordered proteins / Allan Chris M. Ferreon ... [et al.] -- Measuring the energetic coupling of tertiary contacts in RNA folding using single molecule fluorescence resonance energy transfer / Max Greenfield and Daniel Herschlag -- A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis / Jingyi Fei ... [et al.] -- Watching individual proteins acting on single molecules of DNA / Ichiro Amitani ... [et al.] -- DNA curtains for high-throughput single-molecule optical imaging / Eric C. Greene ... [et al.] -- Scanning FCS for the characterization of protein dynamics in live cells / Zdenĕk Petrás̆ek, Jonas Ries and Petra Schwille -- Observing protein interactions and their stoichiometry in living cells by brightness analysis of fluorescence fluctuation experiments / Yan Chen ... [et al.] -- Detection of individual endogenous RNA transcripts in situ using multiple singly labeled probes / Arjin Raj and Sanjay Tyagi -- Single mRNA tracking in live cells / Hye Yoon Park, Adina R. Buxbaum and Robert H. Singer -- Single-molecule sequencing: sequence methods to enable accurate quantitation / Christopher Hart ... [et al.] -- Real-time DNA sequencing from single polymerase molecules / Jonas Korlach ... [et al.].
  • Small molecule microarrays 2010, Springer Protocols
    The Expanding World of Small Molecule Microarrays / Mahesh Uttamchandani and Shao Q. Yao -- Construction of Photo-Cross-Linked Microarrays of Small Molecules / Naoki Kanoh -- Small Molecule Microarray : Functional-Group Specific Immobilization of Small Molecules / Hyang Yeon Lee and Seung Bum Park -- Detecting Protein-Small Molecule Interactions Using Fluorous Small Molecule Microarrays / Arturo J. Vegas and Angela N. Koehler -- A Method for Small Molecule Microarray-Based Screening for the Rapid Discovery of Affinity-Based Probes / Haibin Shi, Mahesh Uttamchandani, and Shao Q. Yao -- Nanodroplet Chemical Microarrays and Label-Free Assays / Dhaval Gosalia and Scott L. Diamond -- Nanodroplet Microarrays for High-Throughput Enzyme Screening / Kang L.D. Aw, Shao Q. Yao, and Mahesh Uttamchandani.The Application of the Chemical Array for Biological Study / Isao Miyazaki, Siro Simizu, and Hiroyuki Osada -- Peptide Arrays with a Chip / Alexander Nesterov, Edgar Dörsam, Yun-Chien Cheng, Christopher Schirwitz, Frieder Märkle, Felix Löffler, Kai König, Volker Stadler, Ralf Bischoff, and Frank Breitling -- In situ Chemical Modification of Peptide Microarrays : Characterization by Desorption/Ionization on Silicon Nanowires / Gaëlle Piret, Herv Drobecq, Carine Rouanet, Karim Chemlal, Anne-Sophie Debrie, Jean-Michel Hougardy, Françoise Mascart, Camille Locht, and Oleg Melnyk -- Peptide Microarrays on Coated Silicon Slides for Highly Sensitive Antibody Detection / Marina Cretich, Francesco Damin, Renato Longhi, Cecilia Gotti, Clelia Galati, Lucio Renna, and Marcella Chiari.Antibody Signatures Defined by High-Content Peptide Microarray Analysis / Antonia Masch, Johannes Zerweck, Ulf Reimer, Holger Wenschuh, and Mike Schutkowski -- High Density Peptide Microarrays for Proteome-Wide Fingerprinting of Kinase Activities in Cell Lysates / Alexandra Thiele, Matthias Weiwad, Johannes Zerweck, Gunter Fischer, and Mike Schutkowski -- A Peptide Microarray for Detecting Protein Kinase Activity in Cell Lysates / Xiaoming Han and Yoshiki Katayama -- Chemical Microarrays Constructed by Selective Attachment of Hydrazide-Conjugated Substances to Epoxide Surfaces and Their Applications / Sungjin Park, Myung-Ryul Lee, and Injae Shin -- A Microarray-Based Method to Perform Nucleic Acid Selections / Olga Aminova and Matthew D. Disney.
  • Somatic embryogenesis 2006, Springer
  • Part I. Basic statistics -- 1. Experimental statistics for biological sciences / Heejung Bang and Marie Davidian -- 2. Nonparametric methods for molecular biology / Knut M. Wittkowski and Tingting Song -- 3. Basics of Bayesian methods / Sujit K. Ghosh -- 4. The Bayesian t-test and beyond / Mithat Gönen -- -- Part II. Designs and methods for molecular biology -- 5. Sample size and power calculation for molecular biology studies / Sin-Ho Jung -- 6. Designs for linkage analysis and association studies of complex diseases / Yuehua Cui ... [et al.] -- 7. Introduction to epigenomics and epigenome-wide analysis / Melissa J. Fazzari and John M. Greally -- 8. Exploration, visualization, and preprocessing of high-dimensional data / Zhijin Wu and Zhiqiang Wu -- -- Part III . Statistical methods for microarray data -- 9. Introduction to the statistical analysis of two-color microarray data / Martina Bremer, Edward Himelblau, and Andreas Madlung -- 10. Building networks with microarray data / Bradley M. Broom ... [et al.] -- Part IV. Advanced or specialized methods for molecular biology -- 11. Support vector machines for classification: a statistical portrait / Yoonkyung Lee -- 12. An overview of clustering applied to molecular biology / Rebecca Nugent and Marina Meila -- 13. Hidden Markov model and its applications in motif findings / Jing Wu and Jun Xie -- 14. Dimension reduction for high-dimensional data / Lexin Li -- 15. Introduction to the development and validation of predictive biomarker models from high-throughput data sets / Xutao Deng and Fabien Campagne -- 16. Multi-gene expression-based statistical approaches to predicting -- patients' clinical outcomes and responses / Feng Cheng, Sang-Hoon Cho, and Jae K. Lee -- 17. Two-stage testing strategies for genome-wide association studies in family-based designs / Amy Murphy, Scott T. Weiss, and Christoph Lange -- 18. Statistical methods for proteomics / Klaus Jung -- -- Part V. Meta-analysis for high-dimensional data -- 19. Statistical methods for integrating multiple types of high-throughput data / Yang Xie and Chul Ahn -- 20. A Bayesian hierarchical model for high-dimensional meta-analysis / Fei Liu -- 21. Methods for combining multiple genome-wide linkage studies / Trecia A. Kippola and Stephanie A. Santorico -- -- Part VI. Other practical information -- 22. Improved reporting of statistical design and analysis: guidelines, education, and editorial policies / Madhu Mazumdar, Samprit Banerjee, and Heather L. Van Epps -- 23. Stata companion / Jennifer Sousa Brennan.
  • Markov models in molecular evolution / Nicolas Galtier, Olivier Gascuel, and Alain Jean-Marie -- Introduction to applications of the likelihood function in molecular evolution / Jutta Buschbom and Arndt von Haeseler -- Introduction to Markov chain Monte Carlo methods in molecular evolution / Bret Larget -- Population genetics of molecular evolution / Carlos D. Bustamante -- Maximum likelilhood methods for detecting adaptive protein evolution / Joseph P. Bielawski and Ziheng Yang -- HyPhy: hypothesis testing using phylogenies / Sergei L. Kosakovsky Pond and Spencer V. Muse -- Bayesian analysis of molecular evolution using MrBayes / John P. Huelsenbeck and Fredrik Ronquist -- Estimation of divergence times from molecular sequence data / Jeffrey L. Thorne and Hirohisa Kishino -- Markov models of protein sequence evolution / Matthew W. Dimmic -- Models of microsatellite evolution / Peter Calabrese and Raazesh Sainudiin -- Genome rearrangement / Rick Durrett -- Phylogenetic hidden Markov models / Adam Siepel and David Haussler -- The evolutionary causes and consequences of base composition variation / Gilean A.T. McVean -- Statistical alignment: recent progress, new applications, and challenges / Gerton Lunter ... [et al.] -- Estimating substitution matrices / Von Bing Yap and Terry Speed -- Posterior mapping and posterior predictive distributions / Jonathan P. Bollback -- Assessing the uncertainty in phylogenetic inference / Hidetoshi Shimodaira and Masami Hasegawa.
  • Bioinformatics in membrane protein analysis / Bengt Persson -- Prokaryotic membrane transport proteins / Joanne Clough ... [et al.] -- Membrane protein production strategies for structural genomics / Said Eshaghi and Par Nordlund -- Refolding of membrane proteins for large-scale production / Hans Kiefer, Thomas Ostermann, Monika Bahner -- Crystallization of membrane proteins / Alastair T. Gardiner, June Southall, and Richard J. Cogdell -- Signaling through membrane proteins / J. Robert Bostwick and Deborah S. Hartman -- Expression of membrane proteins in yeasts / Christoph Reinhart, Christoph Krettler -- Expression of functional membrane proteins in the baculovirus-insect cell system / Giel J.C.G.M. Bosman and Willem J. de Grip -- Expression of membrane proteins in mammalian cells / Kenneth Lundstrom -- Solubilization and purification of membrane proteins / Bernadette Byrne and Mika Jormakka -- Fluorescent labelling of membrane proteins in living cells / Ruud Hovius ... [et al.] -- Membrane protein NMR / Xiang-Qun (Sean) Xie -- Miniaturization of structural biology technologies--from expression to biophysical analyses / Enrique Abola, Peter Kuhn, and Raymond C. Stevens -- Electron microscopy and atomic force microscopy of reconstituted membrane proteins / Andreas Engel -- -- Structural genomics networks for membrane proteins / Kenneth Lundstrom -- Molecular modelling of membrane proteins / Slawomir Filipek and Anna Modzelewska -- Towards structural bases for GPCR ligand-binding / Sabrina A. Beretta ... [et al.].
  • Structural proteomics 2008, Springer Protocols
    Target selection for structural genomics : an overview / Russell L. Marsden and Christine A. Orengo -- A general target selection method for crystallographic proteomics / Gautier Robin ... [et al.] -- Target selection : triage in the structural genomics battlefield / James Raftery -- Data management in structural genomics : an overview / Sabrina Haquin ... [et al.] -- Data deposition and annotation at the worldwide protein data bank / Shuchismita Dutta ... [et al.] -- Prediction in protein disorder / Zsuzsanna Dosztányi and Peter Tompa -- Protein domain prediction / Helgi Ingolfsson and Golan Yona -- Protein structure modeling with MODELLER / Narayanan Eswar ... [et al.] -- High throughput cloning with restriction enzymes / Volker Sievert, Asgar Ergin, and Konrad Bussow -- Automated recombinant protein expression screening in Escherichia coli / Didier Busso ... [et al.] -- From no expression to high-level soluble expression in Escherichi coli by screening a library of the target proteins with randomized N-termini / Kyoung Hoon Kim ... [et al.] -- Application of high-throughput methodologies to the expression of recombinant proteins in E. coli / Yoav Peleg and Tamar Unger -- A high throughput platform for eukaryotic genes / Yunjia Chen ... [et al.] -- High throughput production of recombinant human proteins for crystallography / Opher Gileadi ... [et al.] -- Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts : an overview / Anastassis Perrakis and Christophe Romier -- Cell-free protein synthesis for analysis by NMR spectroscopy / Margit A. Apponyi ... [et al.] --A medium or high throughput protein refolding assay / Nathan P. Cowieson ... [et al.] -- Structural proteomics of membrane proteins : a survey of published techniques and design of a rational high throughput strategy / Melissa Swope Willis and Christopher M. Koth -- Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering / Joanne E. Nettleship ... [et al.] -- High throughput methods for analyzing transition metals in proteins on a microgram scale / Anelia Atanassova, Martin Högbom, and Deborah B. Zamble -- High throughput screening of purified proteins for enzymatic activity / Michael Proudfoot ... [et al.] -- Strategies for improving crystallization success rates / Rebecca Page -- Protein crystallization in restricted geometry : advancing old ideas for modern times in structural proteomics / Joseph D. Ng, Raymond C. Stevens, and Peter Kuhn -- Fluorescence approaches to growing macromolecule crystals / Marc Pusey, Elizabeth Forsythe, and Aniruddha Achari -- Efficient macromoleular crystallization using microfluidics and randomized design of screening reagents / Andrew P. May and Brent W. Segelke -- Increasing protein crystallization screening success with heterogeneous nucleating agents / Anil S.Thakur ... [et al.] -- High throughput pH optimization of protein crystallization / Ran Meged, Orly Dym, and Joel L. Sussman -- Automated structure solution with the PHENIX suite / Peter H. Zwart ... [et al.] -- NMR screening for rapid protein characterization in structural proteomics / Justine M. Hill -- Microcoil NMR spectroscopy : a novel tool for biological high throughput NMR spectroscopy / Russell E. Hopson and Wolfgang Peti --Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling / Dmitri Mouradov ... [et al.] -- Structural genomics of minimal organisms : pipeline and results / Sung-Hou Kim ... [et al.] -- Structural genomics of pathogenic protozoa : an overview / Erkang Fan ... [et al.] -- High throughput crystallography at SGC Toronto : an overview / Alexey Bochkarev and Wolfram Tempel -- The structural biology and genomics platform in Strasbourg : an overview / Didier Busso, Jean-Claude Thierry, and Dino Moras -- Bacterial structural genomics initiative : overview of methods and technologies applied to the process of structure determination / Miroslaw Cygler ... [et al.] -- High-throughput protein production and crystallization at NYSGXRC / Michael J. Sauder ... [et al.] -- Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland / Weining Meng ... [et al.] -- Structural genomics of the bacterial mobile metagenome : an overview / Andrew Robinson ... [et al.].
  • Systems biology 2007, Springer
  • Systems biology 2005, Springer
  • This book summarizes the state-of-the art in the development of T cell-based in vitro assays, which offer useful tools for hazard identification, risk assessment and improvement of diagnostics. It will be of interest to scientists, the chemical and pharmaceutical industry, and regulators involved in the replacement of animal testing methods. The identification of hazardous chemicals and drugs is essential to ensuring human health. The ban on animal testing for the cosmetics industry since 2009 and international efforts to reduce and replace animal testing in research and immunotoxicology call for alternative in vitro methods. The most specific immune response to chemicals and drugs that cause allergic contact dermatitis, respiratory disease and adverse drug reactions is the highly antigen-specific T lymphocyte response. Therefore the use of T cells as tools for identifying contact allergens and drugs that may cause health problems is of great interest.
  • Tetrapyrroles 2009, Springer
    An historical introduction to porphyrin and chlorophyll synthesis / Michael R. Moore -- Biosynthesis of 5-aminolevulinic acid / Dieter Jahn and Dirk W. Heinz -- 5-aminolaevulinic acid dehydratase, porphobilinogen deaminase and uroporphyrinogen III synthase / Heidi L. Schubert, Peter T. Erskine and Jonathan B. Cooper -- Transformation of uroporphyrinogen III into protohaem / Johanna E. Cornah and Alison G. Smith -- Inherited disorders of haem synthesis: the human porphyrias / Michael N. Badminton and George H. Elder -- Heme degradation: mechanistic and physiological implications / Angela Wilks -- Regulation of mammalian heme biosynthesis / Amy E. Medlock and Harry A. Dailey -- Tetrapyrroles in photodynamic therapy / David I. Vernon and Ian Walker -- Heme transport and incorporation into proteins / Linda Thöny-Meyer -- Heme and hemoproteins / Andrew W. Munro ... [et al.] -- Novel heme-protein interactions: some more radical than others / Ann Smith -- Synthesis and role of bilins in photosynthetic organisms / Nicole Frankenberg-Dinkel and Matthew J. Terry -- Phytochromes: bilin-linked photoreceptors in bacteria and plants / Matthew J. Terry and Alex C. McCormac --Biosynthesis of chlorophyll and bacteriochlorophyll / Derren J. Heyes and C. Neil Hunter -- Regulation of tetrapyrrole synthesis in higher plants / Matthew J. Terry and Alison G. Smith -- Regulation of the late steps of chlorophyll biosynthesis / Wolfhart Rudiger -- Chlorophyll breakdown / Bernhard Kräutler -- Vitamin B12: biosynthesis of the corrin ring / Ross M. Graham, Evelyne Deery and Martin J. Warren -- Conversion of cobinamide into coenzyme B12 / Jorge C. Escalante-Semerena ... [et al.] -- The regulation of cobalamin biosynthesis / Jeffrey G. Lawrence -- Coenzyme B12-catalyzed radical isomerizations / Dominique Padovani and Ruma Banerjee -- Biosynthesis of siroheme and coenzyme F430 / Martin J. Warren, Evelyne Deery and Ruth-Sarah Rose -- Role of coenzyme F430 in methanogenesis / Evert C. Duin -- The role of siroheme in sulfite and nitrite reductases / M. Elizabeth Stroupe and Elizabeth D. Getzoff -- The role of heme d1 in denitrification / Stuart J. Ferguson.
  • Scientific Foundation for Global Computing / Robin Milner -- Interdisciplinary Innovation in International Initiatives / John C. Wooley -- A Grand Challenge for Converging Sciences / Ronan Sleep -- Applying Computer Science Research to Biodiversity Informatics: Some Experiences and Lessons / Andrew C. Jones -- e-Science and the VL-e Approach / L.O. (Bob) Hertzberger -- From Syntax to Semantics in Systems Biology Towards Automated Reasoning Tools / François Fages -- SYMBIONIC: A European Initiative on the Systems Biology of the Neuronal Cell / Ivan Arisi, Paola Roncaglia, Vittorio Rosato, Antonino Cattaneo -- A Biological Approach to Autonomic Communication Systems / Iacopo Carreras, Imrich Chlamtac, Francesco De Pellegrini, Csaba Kiraly, Daniele Miorandi, Hagen Woesner -- The Twilight of the Despotic Digital Civilization / Michel Riguidel -- A Compositional Approach to the Stochastic Dynamics of Gene Networks / Ralf Blossey, Luca Cardelli, Andrew Phillips -- A Weighted Profile Based Method for Protein-RNA Interacting Residue Prediction / Euna Jeong, Satoru Miyano.

Shortcut to Licensed Content

Lane Gateway to Licensed Content

  • Select "Add to Favorites" (click “Continue” if you see a security alert)
  • From the "Create in" menu, select “Links” (IE7) or “Favorites Bar” (IE8, IE9) to install

Shortcut for iPhone

Lane Gateway to Licensed Content

  • Drag this button to your Safari bookmarks bar
  • Open iTunes and sync your iPhone; make sure "Sync Safari Bookmarks" under iPhone Info tab is selected
  • To invoke the bookmarklet on your iPhone, open Safari and tap the "Bookmarks" icon
  • Tap "Bookmarks Bar"
  • Tap "Lane Proxy Bookmarklet"

What is it?

This shortcut (Lane proxy bookmarklet) gives you access to resources licensed by the library even when you're not coming from a Lane or a Stanford IP address.

While we'd like Lane to be your gateway to our licensed content, we recognize that links to books, articles and journals come from a variety of different sources (Google, your email, RSS reader, etc.).

Lane Proxy Bookmarklet in the Bookmarks Bar
Up arrow

When installed, it will look your browser bookmark.

At the page you would like to proxy, click the "Lane Gateway to Licensed Content" to invoke it.

If Lane licenses that content, you'll get access as if you were on campus.

How does it work?

This shortcut (Lane proxy bookmarklet) is a combination of a browser bookmark and a JavaScript application. In other words, it's a bookmark that can be programmed to do things. The Lane proxy bookmarklet simply prepends the Lane proxy URL to the current URL in your browser.

This allows you to view the URL as though you were on campus, giving you access to materials licensed for use by the Stanford academic community.

If you're not authenticated, you'll be prompted for your SUNetID and password.

Don't see the Toolbar, Bookmarks, or Links or Favorites bar?

FireFox

From the "View" menu, select "Toolbars" & choose "Bookmarks Toolbar"

 

Safari

From the "View" menu, choose "Show Bookmarks Bar"

 

Chrome

From the "View" menu, choose "Always Show Bookmarks Bar"

 

Internet Explorer

IE controller bar
  • Right-click in a clear area near the browser address bar
  • In the menu, check a box next "Links" (IE7) or "Favorites" (IE8, IE9)
  • Managing IE Favorites

Caveats

This shortcut (Lane proxy bookmarklet) only works with resources Lane has licensed and configured to work with our proxy server.

If invoked on a resource we do not license and/or have not yet configured, you will see an error message:

The Lane proxy server cannot complete your request because this host has not been configured properly.

We make no attempt to configure our proxy server for every resource, only those we license and for which a Stanford IP address grants access.

Drag this button onto your browser toolbar to install.

  • Right click this button
  • Select "Add to Favorites", click "Continue" if you see a security alert
  • In "Create in" menu, select "Links" (IE7) or "Favorites Bar" (IE8, IE9) to install

Drag this button onto Safari Bookmarks bar to install.

There are 120 high level MeSH Subject Headings under which all MeSH terms fall. Choose a subject heading to see the journals Lane offers in that subject area.

 

NEW BOOK

New Book

Edited by Thomas A. Fleisher, Anthony J. Frew, Robert R. Rich, Harry W. Schroeder, Jr., William T. Shearer, Cornelia M. Weyand

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides one-click access to important clinical resources; includes evidence-based diagnosis and treatment guidelines, Books, EBM articles, Ovid MEDLINE, Drug facts and comparisons, Drug interaction facts, guidelines from National Guideline Clearinghouse, patient handouts (English and Spanish), and local content.MD consult provides access to textbooks, electronic journals, practice guidelines, drug information, and patient education handouts.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
School of Medicine