Books by Subject

Microbiology

  • Digital
    Toy, Eugene C.
    Digital : AccessMedicine2006-
    Clinical cases selected from the LANGE Case Files series, edited by Eugene C. Toy, MD.
  • Digital
    Yi-Wei Tang, Charles W. Stratton, editors.
    Digital : Springer2013
  • Digital
    Vijay C. Verma, Alan C. Gange, editors.
    Digital : Springer2014
    In recent years there has been significant attention paid on the endophytic research by various groups working within this domain. Mutualistic endophytic microbes with an emphasis on the relatively understudied fungal endophytes are the focus of this special book. Plants are associated with micro-organisms: endophytic bacteria and fungi, which live inter- and intra-cellularly without inducing pathogenic symptoms, but have active biochemical and genetic interactions with their host. Endophytes play vital roles as plant growth promoters, biocontrol agents, biosurfactant producers, enzymes and secondary metabolite producers, as well as providing a new hidden repertoire of bioactive natural products with uses in pharmaceutical, agrochemical and other biotechnological applications. The increasing interest in endophytic research generates significant progress in our understanding of the host-endophyte relationship at molecular and genetic level. The bio-prospection of microbial endophytes has led to exciting possibilities for their biotechnological application as biocontrol agent, bioactive metabolites, and other useful traits. Apart from these virtues, the microbial endophytes may be adapted to the complex metabolism of many desired molecules that can be of significant industrial applications. These microbes can be a useful alternative for sustainable solutions for ecological control of pests and diseases, and can reduce the burden of excess of chemical fertilizers for this purpose. This book is an attempt to review the recent development in the understanding of microbial endophytes and their potential biotechnological applications. This is a collection of literature authored by noted researchers having signatory status in endophytic research and summarizes the development achieved so far, and future prospects for further research in this fascinating area of research.
  • Digital
    edited by A. D. Hocking, J.I. Pitt, R.A. Samson and U. Thrane.
    Digital : Springer2006
    Print2006
    Section 1. Understanding the fungi producing important mycotoxins -- Section 2. Media and method development in food mycology -- Section 3. Physiology and ecology of mycotoxigenic fungi -- Section 4. Control of fungi and mycotoxins in foods.
  • Digital
    Gianfranco Donelli, editor.
    Digital : Springer2016
  • Digital
    Gianfranco Donelli, editor.
    Digital : Springer2016
    Print2016
    Comparative evaluation of the antimicrobial activity of 19 essential oils / Naouel Chaftar, Marion Giradot, Jérôme Labanowski, Tawfik Ghrairi, Khaled Hani, Jacques Frère, and Christine Imbert -- Advances in microbiology, infectious diseases and public health: refractory Trichophyton rubrum infections in Turin, Italy: a problem still present / Vivian Tullio, Ornella Cervetti, Janira Roana, Michele Panzone, Daniela Scalas, Chiara Merlino, Valeria Allizond, Giuliana Banche Narcisa Mandras, and Anna Maria Cuffini -- Antioxidant hydroxytyrosol-based polyacrylate with antimicrobial and antiadhesive activity versus Staphylococcus epidermidis / Fernanda Crisante, Vincenzo Taresco, Gianfranco Donelli, Claudia Vuotto, Andrea Martinelli, Lucio D'Ilario, Loris Pietrelli, Iolanda Francolini, and Antonella Piozzi -- The role of human herpesvirus 8 in diabetes mellitus type 2: state of the art and a medical hypothesis / Raffaello Pompei -- Prevalence of Chlamydia trachomatis, Trichomonas vaginalis and Neisseria gonorrhoeae based on data collected by a network of clinical microbiology laboratories, in Italy / Maria Cristina Salfa, Barbara Suligoi and Italian STI Laboratory-based Surveillance Working Group -- [Beta]-defensins: work in progress / Giovanna Donnarumma, Iole Paoletti, Alessandra Fusco, Brunella Perfetto, Elisabetta Buommino, Vincenza de Gregorio, and Adone Baroni -- Emergence of Escherichia coli sequence type 131 (ST131) and ST3948 with KPC-2, KPC-3 and KPC-8 carbapenemases from a long-term care and rehabilitation facility (LTCRF) in northern Italy / Aurora Piazza, Mariasofia Caltagirone, Ibrahim Bitar, Elisabetta Nucleo, Melissa Spalla, Elena Fogato, Roberto D'Angelo, Laura Pagani, and Roberta Migliavacca -- Carbapenem-resistant Klebsiella pneumoniae: results of a laboratory surveillance program in an Italian general hospital (August 2014--January 2015) / Claudia Monari, Luca Merlini, Emanuela nardelli, Maria Cacioni, Antonella Repetto, Antonella Mencacci, and Anna Vecchiarelli -- A snapshot of drug-resistant M. tuberculosis strains in Croatia / Ljiljana Zmak, Mihaela Obrovac, and Vera Katalinic-Jankovic -- Quorum quenching strategy targeting gram-positive pathogenic bacteria / Ravindra Pal Singh, Said E. Desouky, and Jiro Nakayama.
  • Digital
    Gianfranco Donelli, editor.
    Digital : Springer2016
    Print2016
    Biodiversity of intestinal lactic acid bacteria in the healthy population -- Clostridium difficile in food and animals: a comprehensive review -- Russian kefir grains microbial composition and its changes during production process.
  • Digital
    Gianfranco Donelli, editor.
    Digital : Springer2017
  • Digital
    Russell H. Vreeland, editor.
    Digital : Springer2012
    Approaches toward the study of halophilic microorganisms in their natural environments : who are they and what are they doing? / Aharon Oren -- Media and conditions for the growth of halophilic and halolerant bacteria and ardchaea / Mark A. Schneegurt -- Taxonomy of halophilic archaea and bacteria / Antonio Ventosa ... [et al.] -- Halophilic viruses / Shereen Sabet -- Microorganisms in evaporites : review of modern geomicrobiology / Tim K. Lowenstein -- Searching for microbes and DNA in ancient halite / Russell H. Vreeland -- DNA replication and repair in halophiles / Adrienne Kish and Jocelyne DiRuggiero -- Gene transfer mechanisms, population genetics/genimics and the evolution of haloarchaea / R. Thane Papke and Scott Chimileski -- Worth your salt : halophiles in education / Bonnie K. Baxter, Jaimi K. Butler and Betsy Kleba -- Halophiles in the public media / Russell H. Vreeland.
  • Digital
    Alzira Maria Paiva de Almeida, Nilma Cintra Leal, editors.
    Digital : Springer2012
    Print2012
  • Digital
    Jürgen Harder, Jens-M. Schröder, editors.
    Digital : Springer2016
    Antimicrobial peptides in cutaneous wound healing -- Antimicrobial peptides as endogenous antibacterials and antivirals at the ocular surface -- Function of antimicrobial peptides in lung innate immunity -- Role of antimicrobial peptides to prevent infections in the kidney and urinary tract -- Antimicrobial peptides in the gut -- Metal sequestration: An important contribution of antimicrobial peptides to nutritional immunity -- Regulation of antimicrobial peptide gene expression by vitamin D -- Dichotomous roles of cationic polypeptides targeting HIV -- Antimicrobial peptides in host-defense: functions beyond antimicrobial activity.
  • Digital
    W.M. Shafer (ed.).
    Digital : Springer2006
    Print2006
    Paneth cell [alpha]-defensin synthesis and function / A.J. Ouellette -- Immunomodulatory properties of defensins and cathelicidins / D.M.E. Bowdish, D.J. Davidson, and R.E.W. Hancock -- Host antimicrobial defence peptides in human disease / B. Agerberth and G.H. Guðmundsson -- Antimicrobial peptides: an essential component of the skin defensive barrier / M.H. Braff and R.L. Gallo -- Antimicrobial peptides versus invasive infections / M.R. Yeaman and A.S. Bayer -- Antimicrobial peptides in the airway / D.M. Laube ... [et al.] -- Hepcidin: a peptide hormone at the interface of innate immunity and iron metabolism / T. Ganz -- Innate host defense of human vaginal and cervical mucosae / A.M. Cole -- Molecular mechanisms of bacterial resistance to antimicrobial peptides / D. Kraus and A. Peschel -- Bacterial evasion of antimicrobial peptides by biofilm formation / M. Otto.
  • Digital
    edited by Pieter S. Hiemstra, Sebastian A.J. Zaat.
    Digital : Springer2013
    Print2013
    Evolution of Antimicrobial Peptides: A View from the Cystine Chapel -- Innate Immunity in Plants: The Role of Antimicrobial Peptides -- Antimicrobial Peptides Produced by Microorganisms -- LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide -- Wound Repair and Antimicrobial Peptides -- WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2 -- Histatins: Multifunctional Salivary Antimicrobial Peptides -- Structure-Function Relationships of Antimicrobial Chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial Peptides and Inflammatory Bowel Disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial Peptides in Chronic Obstructive Pulmonary Disease -- Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo -- Helping the Host: Induction of Antimicrobial Peptides as a Novel Therapeutic Strategy Against Infections.
  • Digital
    World Health Organization.
    Digital : WHO2014
    Print2014
    This report examines, for the first time, the current status of surveillance and information on antimicrobial resistance (AMR) at country level worldwide, with particularly attention to antibacterial resistance.
  • Digital
    editors, Chin-Yi Chen, Xianghe Yan, Charlene R. Jackson.
    Digital : ScienceDirect2015
    1. Introduction to antimicrobial-resistant foodborne pathogens / Patrick Butaye, Maria Angeles Argudín and John Threlfall -- 2. Antimicrobial resistance of Shiga toxin-producing Escherichia coli / Jinru Chen -- 3. Antibiotic resistance in pathogenic Salmonella / Steven C. Ricke and Juliany Rivera Calo -- 4. Antimicrobial resistance and Campylobacter jejuni and C. coli / Mirko Rossi, Satu Olkkola, Mati Roasto, Rauni Kivistö and Marja-Liisa-Hänninen -- 5. Antimicrobial resistance in Yersinia enterocolitica / Anna Fabrega, Clara Ballesté-Delpierre and Jordi Vila -- 6. Antimicrobial resistance in Vibrio species / Craig Baker-Austin -- 7. Antimicrobial resistance in Shigella species / Keith A. Lampel -- 8. Antimicrobial resistance in Listeria spp. / Nathan A. Jarvis, Philip G. Crandall, Corliss A. O'Bryan and Steven C. Ricke -- 9. Antibiotic resistance in Enterococci : a food safety perspective / Anuradha Ghosh and Ludek Zurek -- 10. Clostridium difficile: a food safety concern? / Jane W. Marsh and Lee H. Harrison -- 11. Methods for the detection of antimicrobial resistance and the characterization of Staphylococcus aureus isolates from food-producing animals and food of animal origin / Kristina Kadlec, Sarah Wendlandt, Andrea T. Fessler and Stefan Schwarz -- 12. Non-phenotypic tests to detect and characterize antibiotic resistance mechanisms in Enterobacteriaceae / Agnese Lupo, Krisztina M. Papp-Wallace, Robert A. Bonomo and Andrea Endimiani -- 13. Monitoring and surveillance : the national antimicrobial resistance monitoring system / Emily Crarey, Claudine Kabera and Heather Tate -- 14. Risk assessment of antimicrobial resistance / H. Gregg Claycamp -- 15. Food microbial safety and animal antibiotics / Louis Anthony (Tony) Cox -- 16. Antibiotic-resistant bacteria and resistance genes in the water-food nexus of the agricultural environment / Pei-Ying Hong -- 17. Development and application of novel antimicrobials in food and food processing / Yangjin Jung and Karl R. Matthews -- 18. Database resources dedicated to antimicrobial peptides / Guangshun Wang -- 19. Metabolic network analysis-based identification of antimicrobial drug target in pathogenic bacteria / Vinayak Kapatral -- 20. Application of metagenomic technologies for antimicrobial resistance and food safety research and beyond / Chin-Yi Chen, Xianghe Yan, Siyun Wang and Charlene R. Jackson.
  • Digital
    [edited] by Patricia L. Keen, Raphaël Fugère.
    Digital : Wiley2018
    Antimicrobial resistance genes and wastewater treatment / Mehrnoush Mohammadali and Julian Davies -- When pathogens and environmental organisms meet : consequences for antibiotic resistance / Jose Luis Martinez and Fernando Baquero -- One health : the role wastewater treatment plants play as reservoirs, amplifiers, and transmitters of antibiotic resistance genes and antibiotic resistant bacteria / Marilyn C. Roberts -- Assessing the impact of wastewater treatment plants on environmental levels of antibiotic resistance / Jessica Williams-Nguyen, Irene Bueno, and Randall S. Singer -- Navigating through the challenges associated with the analysis of antimicrobials and their transformation products in wastewater / Randolph R. Singh, Rachel A Mullen and Diana S. Aga -- Metagenomic approaches for antibiotic resistance gene detection in wastewater treatment plants / Ying Yang and Tong Zhang -- Antimicrobials and antimicrobial resistant bacteria in Australia / Andrew J. Watkinson and Simon D. Costanzo -- The mobile resistome in wastewater treatment facilities and downstream environments / Roberto B.M. Marano and Eddie Cytryn -- Bacterial diversity and antibiotic resistance genes in wastewater treatment plant influents and effluents / Veiko Voolaid, Erica Donner, Sotirios Vasileiadis, and Thomas U. Berendonk -- The effect of advanced treatment technologies on the removal of antibiotic resistance -- Popi karaolia, Stella Michael, and Despo Fatta-Kassinos -- Antimicrobial resistance spread mediated by wastewater irrigation: the Mezquital Valley case study / Melanie Broszat and Elisabeth Grohmann -- Antimicrobial resistance related to agricultural wastewater and biosolids / Lisa M. Durso and Amy Millmier Schmidt -- Environmental antibiotic resistance associated with land application of biosolids / Jean E. Mclain, Channah M. Rock, and Charles P. Gerba -- High throughput method for analyzing antibiotic resistance genes in wastewater treatment plants / Johanna Muurinen, Antti Karkman, and Marko Virta -- Antibiotic resistance and wastewater treatment process / Thi Thuy Do, Sinéad Murphy, and Fiona Walsh -- Antibiotic pollution and occurrence of bacterial antibiotic resistance genes in Latin American developing countries : case study of the Katari watershed in the Bolivian highlands / Denisse Archundia, Celine Duwig, Jean M.F. Martins, Frederic Lehembre, Marie-Christine Morel, and Gabriela Flores -- Antimicrobial resistance in hospital wastewaters / Judith Isaac-Renton and Patricia L. Keen -- Curbing the resistance movement : examining public perception of the spread of antibiotic resistant organisms / Agnes V. Macdonald and Patricia L. keen -- Public health consequences of antimicrobial resistance in the wastewater treatment process / Patricia L. Keen, Raphaël Fugère, and David M. Patrick.
  • Digital
    edited by Dilip K. Arora, Randy M. Berka, Gautam B. Singh.
    Digital : ScienceDirect2006
    The advances in genomic technologies, such as microarrays and high throughput sequencing, have expanded the realm of possibilities for capturing data and analyzing it using automated computer driven bioinformatics tools. With the completion of the sequencing of genomes of human and several model organisms, a quest for scientific discoveries being fueled by integrative and multidimensional techniques in mathematics and computational sciences. In this volume, leading researchers and experts have provided an overview of significant concepts from biological, mathematical, and computational perspectives. It provides a high level view of fungal genomic data integration and annotation, classification of proteins and identification of vaccine targets, identification of secretome or secreted proteins in fungal genomes, as well as tools for analyzing microarray expression profiles. * Provides a survey of theoretical underpinnings on the technological tools and applications * Discusses the tools utilized for the annotation of fungal genomes and addresses issues related to automated annotation generation in a high throughput biotechnology environment * describing the applications of the concepts and methodologies presented throughout the book.
  • Digital
    Audrie Lin.
    Digital2012
    Overview: 555 million preschool children live in developing countries where malnutrition (undernutrition) is a significant problem. The factors that contribute to this issue are multiple, with two important factors being gut microbiota and gut function. To begin to understand gut microbiota and gut function in a developing country, we performed two parallel studies: in the first study, we characterized the baseline gut microbiota of healthy Bangladeshi children, and in the second study, we investigated the association between household environmental conditions and gut function in Bangladeshi children. The gut microbiota affect nutrient metabolism, immune function, and pathogen resistance. Loss of gut function as occurs in environmental enteropathy (a multifaceted, subclinical intestinal disorder likely derived from repeated episodes of infectious gastroenteritis and chronic inflammation) contributes to malnutrition and growth faltering. It is possible that these processes are interrelated with the gut microbiota serving a critical role in environmental enteropathy. Gut microbiota: Previous studies have focused on the gut microbiota of infants and adults from developed countries, but few have characterized the gut microbiota of people living in developing countries. Furthermore, little is known about the gut microbiota and its variation over time in primary-school-age children and adolescents in either developed or developing countries. In this study, we compared the monthly variation in fecal microbiota composition of healthy children (ages 8--14 years) living in an urban slum in Bangladesh with that of age-matched children from affluent suburban communities in the United States. We analyzed 8,000 near full-length sequences of the small-subunit ribosomal RNA gene (16S rDNA) and over 845,000 pyrosequencing reads spanning the V1-V3 variable region of the 16S rDNA. The distal gut of Bangladeshi children harbored significantly higher microbial diversity than U.S. children, a result validated by the discovery of several novel lineages from various bacterial phyla in the full-length Bangladeshi dataset. Bangladeshi and U.S. children displayed distinct gut microbiota architectures. Moreover, significantly lower month-to-month temporal stability was observed in Bangladeshi children compared to U.S. children. Together, these results suggest that different environmental or genetic variables may affect the microbiota of healthy children in the two countries. Further studies are necessary to investigate the underlying mechanisms of these differences and to incorporate these insights into prevention or treatment of diseases. Gut function: Although poor water quality, sanitation, and hygiene are putative risk factors for environmental enteropathy, there are no studies investigating the relationship of household environmental conditions to environmental enteropathy. We compared levels of environmental enteropathy markers to growth patterns and measured the prevalence of parasitic infections in children living in different levels of environmental cleanliness based on indictors of water, sanitation, and hygiene in their households. We conducted a follow-up study of 119 children (< 4 years old) from an existing cohort, living in rural Bangladesh and divided into two types of households: a 'mitigated household' had good water quality, improved sanitation, and a handwashing station stocked with water and soap, and a 'contaminated household' had poor water quality, and inadequate sanitation and handwashing facilities. We measured anthropometry, intestinal parasitic infection, and the following markers to assess gut function: Lactulose:Mannitol (L:M) ratio, immunoglobulin G endotoxin core antibody (IgG EndoCAb), and total IgG. After adjustment for potential confounding, children from mitigated households had higher height-for-age Z-scores (HAZ), lower L:M ratios, and lower IgG EndoCAb titers than children from contaminated households. The L:M ratio was also strongly associated with HAZ in the cohort. Children living in environmentally mitigated households had lower levels of parasitic infection, improved measures of gut function, and improved growth compared to children living in contaminated environments. These results support the hypothesis that environmental contamination mediated through environmental enteropathy could be a cause of growth faltering in low-income countries. Interpretation: By characterizing the baseline gut microbiota of healthy children living in a developing country and correlating their gut function with household environmental conditions, our work provides a foundation to address the role of the gut microbiota and environmental enteropathy in child health.
  • Digital
    edited by Claudine Elmerich and William E. Newton.
    Digital : Springer2007
  • Digital
    Stacey Schultz-Cherry, editor.
    Digital : Springer2013
    Since their initial discovery in the 1970's, astroviruses have been recognized as a leading cause of enteritis in infants, the elderly, and immunocompromised people, and were known to be widespread in animals and birds. In recent years, and with the advent of pyrosequencing, there has been a virtual explosion in the number of newly identified astrovirus genotypes. With this has come an increased understanding in astrovirus biology, structure, epidemiology, immunology, and disease pathogenesis including the likelihood of extraintestinal and systemic infections. The advent of new diagnostic tests that detect all of the currently identify human astrovirus strains may prove that these viruses are more prevalent in populations than currently realized.This book will provide state-of-the-art information on our current understanding of astroviruses for researchers, medical and veterinary providers, and diagnosticians as prepared by the leaders in the respective fields. The goal is to bring the reader up to date on the state of knowledge on this constantly evolving and exciting field of virology.
  • Digital
    Tomohiro Kurosaki, Jürgen Wienands, editors.
    Digital : Springer2016
    Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.
  • Digital
    Dirk Linke, Adrian Goldman, editors.
    Digital : Springer2011
    Print2011
    Adhesins of Human Pathogens from the Genus Yersinia / Jack C. Leo and Mikael Skurnik -- Adhesive Mechanisms of Salmonella enterica / Carolin Wagner and Michael Hensel -- Adhesion Mechanisms of Borrelia burgdorferi / Styliani Antonara, Laura Ristow and Jenifer Coburn -- Adhesins of Bartonella spp. / Fiona O'Rourke, Thomas Schmidgen, Patrick O. Kaiser, Dirk Linke and Volkhard A.J. Kempf -- Adhesion Mechanisms of Plant-Pathogenic Xanthomonadaceae / Nadia Mhedbi-Hajri, Marie-Agnès Jacques and Ralf Koebnik -- Adhesion by Pathogenic Corynebacteria / Elizabeth A. Rogers, Asis Das and Hung Ton-That -- Adhesion Mechanisms of Staphylococci / Christine Heilmann -- Protein Folding in Bacterial Adhesion: Secretion and Folding of Classical Monomeric Autotransporters / Peter van Ulsen -- Structure and Biology of Trimeric Autotransporter Adhesins / Andrzej Łyskowski, Jack C. Leo and Adrian Goldman -- Crystallography and Electron Microscopy of Chaperone / Usher Pilus Systems / Sebastian Geibel and Gabriel Waksman -- Crystallography of Gram-Positive Bacterial Adhesins / Vengadesan Krishnan and Sthanam V. L. Narayana -- The Nonideal Coiled Coil of M Protein and Its Multifarious Functions in Pathogenesis / Partho Ghosh -- Bacterial Extracellular Polysaccharides / Kateryna Bazaka, Russell J. Crawford, Evgeny L. Nazarenko and Elena P. Ivanova -- Carbohydrate Mediated Bacterial Adhesion / Roland J. Pieters -- The Application of NMR Techniques to Bacterial Adhesins / Frank Shewmaker -- Electron Microscopy Techniques to Study Bacterial Adhesion / Iwan Grin, Heinz Schwarz and Dirk Linke -- EM Reconstruction of Adhesins: Future Prospects / Ferlenghi Ilaria and Fabiola Giusti -- Atomic Force Microscopy to Study Intermolecular Forces and Bonds Associated with Bacteria / Steven K. Lower -- Assessing Bacterial Adhesion on an Individual Adhesin and Single Pili Level Using Optical Tweezers / Ove Axner, Magnus Andersson, Oscar Björnham, Mickaël Castelain and Jeanna Klinth, et al. -- Short Time-Scale Bacterial Adhesion Dynamics / Jing Geng and Nelly Henry -- Deciphering Biofilm Structure and Reactivity by Multiscale Time-Resolved Fluorescence Analysis / Arnaud Bridier, Ekaterina Tischenko, Florence Dubois-Brissonnet, Jean-Marie Herry and Vincent Thomas, et al. -- Inhibition of Bacterial Adhesion on Medical Devices / Lígia R. Rodrigues.
  • Digital
    Tony Romeo, editor.
    Digital : Springer2008
    Print2008
  • Digital
    edited by Anne H. Delcour.
    Digital : Springer Protocols2013
    Bird's eye view of the bacterial landscape / Natividad Ruiz -- Visualizing the bacterial cell surface : an overview / Harald Engelhardt -- Purification of the outer membrane usher protein and periplasmic chaperone-subunit complexes from the P and type 1 pilus systems / Nadine S. Henderson and David G. Thanassi -- Experimental manipulation of the microbial functional amyloid called curli / Yizhou Zhou [and others] -- Visualization of gram-positive bacterial pili / Chungyu Chang [and others] -- Single cell microfluidic studies of bacterial motility / Adrien Ducret, Olivier Theodoly, and Tam Mignot -- Chromatographic analysis of the Escherichia coli polysialic acid capsule / Susan M. Steenbergen and Eric R. Vimr -- Analysis of exopolysaccharides in Myxococcus xanthus using confocal laser scanning microscopy / Wei Hu, Renate Lux, and Wenyuan Shi -- Assessment of multidrug efflux assemblies by surface plasmon resonance / Elena B. Tikhonova and Helen I. Zgurskaya -- Fluorescence microscopy and proteomics to investigate subcellular localization, assembly, and function of the type II secretion system / Tanya L. Johnson [and others] -- Pore formation by T3SS translocators : liposome leakage assay / Eric Faudry, Caroline Perdu, and Ina Attree -- Isolation of bacterial type IV machine subassemblies / Mayukh K. Sarkar [and others] -- Production and crystallization of bacterial type V secretion proteins / Hye-Jeong Yeo -- Assembly of bacterial outer membrane proteins / Jan Grijpstra, Martine P. Bos, and Jan Tommassen -- Outer membrane of gram-negative bacteria : lipid A isolation and characterization / Jessica V. Hankins [and others] -- Quantitative and qualitative preparations of bacterial outer membrane vesicles / Halima Chutkan [and others] -- In vitro peptidoglycan synthesis assay with lipid II substrate / Jacob Biboy, Nhat Khai Bui, and Waldemar Vollmer -- Extraction of cell wall-bound teichoic acids and surface proteins from Listeria monocytogenes / Filipe Carvalho [and others] -- Subfractionation and analysis of the cell envelope (lipo) polysaccharides of Mycobacterium tuberculosis / Anna E. Grzegorzewicz and Mary Jackson -- Protein disulfide bond formation in the periplasm : determination / Katleen Denoncin [and others] -- Using reporter genes and the Escherichia coli ASKA overexpression library in screens for regulators of the gram negative envelope stress response / Julia L. Wong, Stefanie L. Vogt, and Tracy L. Raivio -- Isolation of bacteria envelope proteins / Shu Quan [and others] -- Patch clamp electrophysiology for the study of bacterial ion channels in giant spheroplasts of E. coli / Boris Martinac [and others] -- Electrophysiological characterization of bacterial pore-forming proteins in planar lipid bilayers / Owen S. Mapingire, Beau Wager, and Anne H. Delcour.
  • Digital
    Remus T. Dame, Charles J. Dorman, editors.
    Digital : Springer2010
  • Digital
    edited by Jacques van Helden and Ariane Toussaint, Denis Thieffry.
    Digital : Springer Protocols2012
    Bacterial molecular networks : bridging the gap between functional genomics and dynamical modelling / Jacques van Helden, Ariane Toussaint, and Denis Thieffry -- Bacterial interactomes : from interactions to networks / Emmanuelle Bouveret and Christine Brun -- From bacterial to microbial ecosystems (metagenomics) / Shannon J. Williamson and Shibu Yooseph -- Prokaryote genome fluidity : toward a system approach of the mobilome / Ariane Toussaint and Mick Chandler -- Reticulate classification of mosaic microbial genomes using NeAT website / Gipsi Lima-Mendez -- From metabolic reactions to networks and pathways / Masanori Arita -- Predicting metabolic pathways by sub-network extraction / Karoline Faust and Jacques van Helden -- Directed module detection in a large-scale expression compendium / Qiang Fu [and others] -- Using phylogenetic profiles to predict functional relationships / Matteo Pellegrini -- Extracting regulatory networks of Escherichia coli from RegulonDB / Heladia Salgado [and others] -- Browsing metabolic and regulatory networks with BioCyc / Mario Latendresse, Suzanne Paley, and Peter D. Karp -- Algorithms for systematic identification of small subgraphs / Joseph Geraci, Geoffrey Liu, and Igor Jurisica -- The degree distribution of ntworks : statistical model selection / William P. Kelly, Piers J. Ingram, and Michael P.H. Stumpf -- MAVisto : a tool for biological network motif analysis / Henning Schwöbbermeyer and Röbbe Wünschiers -- Using MCL to extract clusters from networks / Stijn van Dongen and Cei Abreu-Goodger -- Protein complex prediction with RNSC / Andrew D. King, Nataša Pržulj, and Igor Jurisica -- Network analysis and protein function prediction with the PRODISTIN web site / Anaïs Baudot, Ouissem Souiai, and Christine Brun -- Using NeAT Toolbox to compare networks to networks, clusters to clusters, and network to clusters / Sylvain Brohée -- Analyzing biological data using R : methods for graphs and networks / Nolwenn Le Meur and Robert Gentleman -- Detecting structural invariants in biological reaction networks / Jörn Behre [and others] -- Petri nets in Snoopy : a unifying framework for the graphical display, computational modelling, and simulation of bacterial regulatory networks / Wolfgang Marwan, Christian Rohr, and Monika Heiner -- Genetic Network Analyzer : a tool for the qualitative modeling and simulation of bacterial regulatory networks / Grégory Batt [and others] -- Logical modelling of gene regulatory networks with GINsim / Claudine Chaouiya, Aurélien Naldi, and Denis Thieffry -- Modelling the evolution of mutualistic symbioses / Maren L. Friesen and Emily I. Jones -- Modelling the onset of virulence in pthogenic bacteria / Wilfred D. Kepseu [and others] -- Spatial and stochastic cellular modeling with the Smoldyn Simulator / Steven S. Andrews.
  • Digital
    edited by Alessio Mengoni, Marco Galardini, Marco Fondi.
    Digital : Springer Protocols2015
    Pulsed field gel electrophoresis and genome size estimates/ Rosa Alduina and Annalisa Pisciotta -- Comparative analyses of extrachromosomal bacterial replicons, identification of chromids, and experimental evaluation of their indispensability / Lukasz Dziewit and Dariusz Bartosik -- Choice of next-generation sequencing pipelines / F. Del Chierico ... [et al.] -- Pyrosequencing protocol for bacterial genomes / Ermanno Rizzi -- Bacterial metabarcoding by 16S rRNA gene ion torrent amplicon sequencing / Elio Fantini ... [et al.] -- Illumina-solexa sequencing protocol for bacterial genomes / Zhenfei Hu, Lei Cheng, and Hai Wang -- High-throughput phenomics / Carlo Viti ... [et al.] -- Comparative analysis of gene expression : uncovering expression conservation and divergence between Salmonella enterica serovar typhimurium strains LT2 and 14028S / Paolo Sonego ... [et al.] -- Raw sequence data and quality control / Giovanni Bacci -- Methods for assembling reads and producing contigs / Valerio Orlandini, Marco Fondi, and Renato Fani -- Mapping contigs using CONTIGuator / Marco Galardini, Alessio Mengoni, and Marco Bazzicalupo -- Gene calling and bacterial genome annotation with BG7 / Raquel Tobes ... [et al.] -- Defining orthologs and pangenome size metrics / Emanuele Bosi, Renato Fani, and Marco Fondi -- Robust identification of orthologues and paralogues for microbial pan-genomics using GET HOMOLOGUES : a case study of pIncA/C plasmids / Pablo Vinuesa and Bruno Contreras-Moreira -- Genome-scale metabolic network reconstruction / Marco Fondi and Pietro Liò -- From pangenome to panphenome and back / Marco Galardini, Alessio Mengoni, and Stefano Mocali -- Genome-wide detection of selection and other evolutionary forces / Zhuofei Xu and Rui Zhou -- Integrated microbial genome resource of analysis / Alice Checcucci and Alessio Mengoni.
  • Digital
    volume editors, Mattias Collin, Raymond Schuch.
    Digital : Karger2009
    Print2009
    Chemical interactions between organisms in microbial communities / Duan, K. ... [et al.] -- Autoinducer-2-based chemical communication in bacteria : complexities of interspecies signaling / Federle, M.J. -- The molecular basis of excitation and adaptation during chemotactic sensory transduction in bacteria / Rao, C.V., Ordal, G.W. -- Bacterial PEP-dependent carbohydrate : phosphotransferase systems couple sensing and global control mechanisms / Lengeler, J.W., Jahreis, K.-- Correlations between carbon metabolism and virulence in bacteria / Poncet, S. ... [et al.] -- Stand-alone response regulators controlling global virulence networks in streptococcus pyogenes / McIver, K.S. -- The heme sensor system of staphylococcus aureus / Stauff, D.L., Skaar, E.P. -- Bacterial sensing of antimicrobial peptides / Otto, M. -- RNA thermosensors in bacterial pathogens / Johansson, J. -- Prevailing concepts of c-di-GMP signaling / Römling, U., Simm, R. -- Magnetosomes and magneto-aerotaxis / Frankel, R.B., Bazylinski, D.A. -- Engineering bacterial signals and sensors / Salis, H., Tamsir, A., Voigt, C.
  • Digital
    edited by Irina Artsimovitch, Thomas J. Santangelo.
    Digital : Springer Protocols2015
    Mapping the Escherichia coli transcription elongation complex with exonuclease III / Zhaokun Liu and Irina Artsimovitch -- Purification of bacterial RNA polymerase : tools and protocols / Vladimir Svetlov and Irina Artsimovitch -- Monitoring translocation of multisubunit RNA polymerase along the DNA with fluorescent base analogues / Anssi M. Malinen, Matti Turtola, and Georgiy A. Belogurov -- In vitro and in vivo methodologies for studying the sigma-54-dependent transcription / Martin Buck [and nine others] -- Methods for the assembly and analysis of in vitro transcription-coupled-to-translation systems / Daniel Castro-Roa and Nikolay Zenkin -- Site-specific incorporation of probes into RNA polymerase by unnatural-amino-acid mutagenesis and Straudinger-Bertozzi ligation / Anirban Chakraborty [and seven others] -- Reconstruction of factor-dependent, promotor proximal pausing in Drosophila nuclear extracts / Jian Li and David S. Gilmour -- Direct competition assay for transcription fidelity / Lucyna Lubkowska and Maria L. Kireeva -- Single-stranded DNA aptamers for functional probing of bacterial RNA polymerase / Danil Pupov and Andrey Kulbachinskiy -- Biochemical analysis of transcription termination by RNA polymerase III from yeast Saccharomyces cerevisiae / Aneeshkumar G. Arimbasseri and Richard J. Maraia -- Use of RNA polymerase molecular beacon assay to measure RNA polymerase interactions with model promotor fragments / Vladimir Mekler and Konstantin Severinov -- Preparation of cDNA libraries for high-throughput RNA sequencing analysis of RNA 5' ends / Irina O. Vvedenskaya, Seth R. Goldman, and Bryce E. Nickels -- In situ footprinting of E. coli transcription elongation complex with chloroacetaldehyde / A. Rachid Rahmouni and Christine Mosrin-Hauman -- Using solutes and kinetics to probe large conformational changes in the steps of transcription initiation / Emily F. Ruff, Wayne S. Kontur, and M. Thomas Record Jr. -- Manipulating archaeal systems to permit analyses of transcription elongation-termination decisions in vitro / Alexandra M. Gehring and Thomas J. Santangelo -- Purification of active RNA polymerase I from yeast / Francis Dean Appling and David Alan Schneider -- Transcription in archaea : preparation of Methanocaldococcus jannaschii transcription machinery / Katherine Smollet, Fabian Blombach, and Finn Werner -- Transcription in archaea ; in vitro transcription assays for mjRNAP / Katherine Smollet, Fabian Blombach, and Finn Werner -- Experimental analysis of hFACT action during pol II transcription in vitro / Fu-Kai Hsieh, Olga I. Kulaeva, and Vasily M. Studitsky -- ChIP-Seq for genome-scale analysis of bacterial DNA-binding proteins / Richard P. Bonocora and Joseph T. Wade.
  • Digital
    M.A. Riley, M.A. Chavan (eds.).
    Digital : Springer2007
  • Digital
    edited by Martha R.J. Clokie and Andrew M. Kropinski.
    Digital : Springer Protocolsv. 1, 2009
    Digital : Springer Protocolsv. 2, 2009
    v. 1. Isolation, characterization, and interactions -- v. 2. Molecular and applied aspects.
  • Digital
    David R. Boone, Richard W. Castenholz, editors , volume one ; George M. Garrity, editor-in-chief ; editorial board, James T. Staley ... [et al.].
    Digital : Springerv. 2a 2005
    Digital : Springerv. 2b 2005
    Digital : Springerv. 2c 2005
    v. 1. The Archaea and the deeply branching and phototrophic bacteria -- v. 2. The Proteobacteria: part A. Introductory essays; part B. The Gammaproteobacteria; part C. The Alpha-, beta-, delta-, and epsilonproteobacteria -- v. 3. The Firmicutes -- v. 4. The Bacteroidetes, Spirochaetes, Tenericutes (Mollicutes), Acidobacteria, Fibrobacteres, Fusobacteria, Dictyoglomi, Gemmatimonadetes, Lentisphaerae, Verrucomicrobia, Chlamydiae, and Planctomycetes -- v. 5. The Actinobacteria.
  • Digital
    supervising editor, William B. Whitman ; editors, Paul DeVos, Jonsik Chun, Sveltlana Dedysh, Brian Hedlund, Peter Kämpfer, Fred Rainey, Martha Trujillo.
    Digital : Wiley2015
  • Digital
    Ulrich Dobrindt, Jörg H. Hacker, Catharina Svanborg, editors.
    Digital : Springer2013
    E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity / Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt -- What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? / Ralf Rosenstein, Friedrich Götz -- Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung / Michael Hogardt, Jürgen Heesemann -- Lactobacillus: Host-Microbe Relationships / John O'Callaghan, Paul W. O'Toole -- Bacterial Moonlighting Proteins and Bacterial Virulence / Brian Henderson, Andrew Martin -- Symbionts and Pathogens: What is the Difference? / Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya -- Ecology and Physiology of the Intestinal Tract / Michael Blaut -- The Gut Microflora and Its Variety of Roles in Health and Disease / Julia-Stefanie Frick, Ingo B. Autenrieth -- Host-Recognition of Pathogens and Commensals in the Mammalian Intestine / Oriana Rossi, Peter van Baarlen, Jerry M. Wells -- Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age / Jing Cheng, Airi M. Palva, Willem M. de Vos.
  • Digital
    volume author, J. William Costerton.
    Digital : Springer2007
  • Digital
    Héctor M. Alvarez, editor.
    Digital : Springer2010
    Systematics of Members of the Genus Rhodococcus (Zopf 1891) Emend Goodfellow et al. 1998: The Past, Present and Future / Volker Gűrtler and Robert J. Seviour -- The Rhodococcal Cell Envelope: Composition, Organisation and Biosynthesis / Iain C. Sutcliffe, Alistair K. Brown and Lynn G. Dover -- Genomes and Plasmids in Rhodococcus / Michael J. Larkin, Leonid A. Kulakov and Christopher C. R. Allen -- Central Metabolism of Species of the Genus Rhodococcus / Héctor M. Alvarez -- Adaptation of Rhodococcus to Organic Solvents / Carla C. C. R. de Carvalho -- Catabolism of Aromatic Compounds and Steroids by Rhodococcus / Katherine C. Yam, Robert van der Geize and Lindsay D. Eltis -- Catabolism of Nitriles in Rhodococcus / Ludmila Martínková, Miroslav Pátek, Alicja Barbara Veselá, Ondřej Kaplan and Bronislava Uhnáková, et al. -- The Desulfurization Pathway in Rhodococcus / Ting Ma -- Application of Rhodococcus in Bioremediation of Contaminated Environments / Maria S. Kuyukina and Irena B. Ivshina -- Physiology, Biochemistry, and Molecular Biology of Triacylglycerol Accumulation by Rhodococcus / Héctor M. Alvarez and Alexander Steinbüchel -- Rhodococcus Biosurfactants: Biosynthesis, Properties, and Potential Applications / Maria S. Kuyukina and Irena B. Ivshina -- Phytopathogenic Strategies of Rhodococcus fascians / Elisabeth Stes, Marcelle Holsters and Danny Vereecke -- Rhodococcus equi and Its Pathogenic Mechanisms / José A. Vázquez-Boland, Michal Letek, Ana Valero-Rello, Patricia González and Mariela Scortti, et al.
  • Digital
    volume editors, R.J. Howard, N.A.R. Gow
    Digital : Springer2007
  • Digital
    Daryl S. Paulson.
    Digital : Springer2008
  • Digital
    edited by Ramkrishna Sen.
    Digital : Springer2010
    Print2010
  • Digital
    Gloria Soberón-Chávez, editor.
    Digital : Springer2011
    Biosurfactants: A General Overview / Gloria Soberón-Chávez and Raina M. Maier -- Rhamnolipids: Detection, Analysis, Biosynthesis, Genetic Regulation, and Bioengineering of Production / Ahmad Mohammad Abdel-Mawgoud, Rudolf Hausmann, Francois Lépine, Markus M. Müller and Eric Déziel -- Surfactin and Other Lipopeptides from Bacillus spp. / Philippe Jacques -- Serrawettins and Other Surfactants Produced by Serratia / Tohey Matsuyama, Taichiro Tanikawa and Yoji Nakagawa -- Trehalolipids / Zongze Shao -- Mannosylerythritol Lipids: Microbial Production and Their Applications / J. Arutchelvi and M. Doble -- Sophorolipids / Inge N. A. Van Bogaert and Wim Soetaert.
  • Digital
    Andreas Rummel, Thomas Binz, editors.
    Digital : Springer2013
    Print2013
    The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
  • Print
    Michael T. Madigan, John M. Martinko, Paul V. Dunlap, David P. Clark.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    Digital : Springerv. 5-, 2002-
  • Digital
    Digital : Springerv. 1-4, 1999-2002.
  • Digital
    Justine Michelle Pompey.
    Digital2012
    Entamoeba histolytica, a human intestinal parasite and a leading cause of death worldwide, contains a complex repertoire of endogenous small RNAs. Core elements of the RNAi machinery have been identified in the E. histolytica genome including three Argonaute proteins (EhAgo2-1, EhAgo2-2, and EhAgo2-3) and two genes with RNA-directed RNA polymerase (RdRP) domains. However, to date no canonical Dicer enzyme, an RNaseIII endonuclease responsible for cleaving double-stranded RNA (dsRNA) to 20-30nt small RNAs and a critical player in the RNAi pathway, has been identified in the E. histolytica genome. We conducted bioinformatics searches of the genome which revealed only one gene with an RNaseIII domain, EhRNaseIII. Interestingly, this candidate lacks the canonical Dicer structure - it is substantially smaller than other Dicers, contains only a single RNaseIII domain, and lacks PAZ or double-stranded RNA binding domain (dsRBD). Most eukaryotic Dicer proteins identified to date contain two RNaseIII domains, which form a heterodimer required for cleavage of the dsRNA, and contain PAZ or dsRBDs. We determined that EhRNaseIII exists as a homodimer in E. histolytica trophozoites. We sought to probe the contributions of EhRNaseIII, EhAgo2-2, and EhRdRP1 to the RNAi pathway in E. histolytica. Attempts to downregulate these genes using RNA-based methods including antisense mediated silencing and the production of gene-specific secondary small RNAs were unsuccessful. Expression of EhRNaseIII dominant-negative mutants also failed to impair production of small RNAs. In order to determine if EhRNaseIII was capable of generating small RNAs of the size observed in E. histolytica trophozoites, we conducted in vitro cleavage assays of dsRNA. Despite using multiple protein sources (E. histolytica whole cell lysate, immunoprecipitated EhRNaseIII, and recombinant EhRNaseIII protein) and two structurally distinct dsRNA substrates, we were unable to detect small RNA cleavage products. We further investigated whether EhRNaseIII was sufficient to act as a Dicer enzyme by co-expressing it with a dsRNA substrate in Saccharomyces cerevisiae, which lacks an RNAi pathway. However, no small RNAs were detected. We also assessed whether EhAgo2-2, which associates with 5'-polyphosphate small RNAs in E. histolytica, could mediate silencing using 5'-monophosphated small RNAs in S. cerevisiae. No downregulation in reporter transcript or protein was observed. These data indicate that EhRNaseIII is not a minimal Dicer enzyme and suggest that small RNA biogenesis may occur solely through a Dicer-independent small pathway in E. histolytica. These data also suggest that EhAgo2-2 may be specific for 5'-polyphosphate small RNAs. Future studies will continue to investigate the mechanism of small RNA-induced silencing in E. histolytica.
  • Digital
    Patrick Ryan Eimerman.
    Digital2010
    Listeria monocytogenes is a facultative intracellular pathogen that causes severe invasive disease in susceptible populations. Using in vivo bioluminescent imaging, it was recently discovered that this bacterium can colonize the murine gallbladder of otherwise asymptomatic mice. This finding was surprising as L. monocytogenes, after invasion of the intestines, was thought to survive only intracellularly in an infected host and in the gallbladder the bacteria lived extracellularly. It was also surprising that a bacterium could grow and replicate in the pure bile environment of the gallbladder lumen as bile is a potent antimicrobial compound. In this study, we characterized how Listeria monocytogenes is able to reach the gallbladder during infection and examined how this pathogen is able to survive in this environment. Using a mouse adapted L. monocytogenes which expresses a modified InlA capable of binding murine E-cadherin we were able to follow the kinetics of gallbladder colonization after oral infection using in vivo bioluminescent imaging. We then utilized surgical manipulation of the mouse host and repeated the oral infection to determine how L. monocytogenes reaches the gallbladder. Once we had determined the mechanism of gallbladder entry, we then utilized whole genome microarrays to characterize the transcriptome of L. monocytogenes during in vivo growth in the gallbladder and in freshly isolated murine bile. Finally, we attempted to determine what nutrients are utilized by L. monocytogenes during growth in bile and looked at the ability of other bacterial species to grow in this environment. Through these experiments we demonstrated regular asymptomatic gallbladder colonization by L. monocytogenes after oral infection and that L. monocytogenes reaches the gallbladder via the hepatic duct only after first causing systemic infection and escaping the liver. We also demonstrated that the lifestyle in the gallbladder is similar to that in the intestine with the exception of the need for bile resistance genes, and finally that it appears as though simple carbon sources may be utilized during bile growth and that bile may not be as toxic to bacteria as has been thought. Our work suggests that gallbladder colonization may not be exclusive to only L. monocyctogenes and Salmonella Typhi since other bacteria can grow, and in some cases better than L. monocyctogenes, in pure bile.
  • Digital
    edited by Patrick F. Fox ... [et al.].
    Digital : ScienceDirectv. 1 (2004)
    Digital : ScienceDirectv. 2 (2004)
    v. 1. General aspects -- v. 2. Major cheese groups.
  • Digital
    Letts, L. Gordon; Moser, Bernhard; Neote, Kuldeep.
    Digital : Springerv. 1, 2006
    Digital : Springerv. 2, 2007
    v. 1. Immunology of chemokines / Bernhard Moser, Gordon L. Letts [sic], Kuldeep Neote (editors) -- v. 2. Pathophysiology of chemokines / Kuldeep Neote, Gordon L. Letts [sic], Bernard Moser (editors).
  • Digital
    edited by Tracy M. Handel and Damon J. Hamel.
    Digital : ScienceDirectpt. A
    Digital : ScienceDirectpt. B
    Chemokines and receptors in disease -- Chemokine related proteins from pathogens -- Atypical and novel chemoattractants and receptors -- Chemokine signaling.
  • Digital
    Keya Chaudhuri, S.N. Chatterjee.
    Digital : Springer2009
  • Digital
    Denis H. Lynn.
    Digital : Springer2008
  • Print
    Mark Gladwin, Bill Trattler.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Digital
    editor in chief, Amy L. Leber, Department of Laboratory Medicine, Nationwide Children's Hospital, Columbus, Ohio.
    Digital : Am Soc Microbiolv. 1-3=, 2016
    Contributors -- In Memoriam -- Contents -- Editorial Board -- How To Use This Handbook -- Abbreviations -- Preface -- Reader Response Form -- Disclaimer -- VOLUME 1 -- Procedure Coding, Reimbursement, and Billing Compliance -- Chapter 1.1 : Introduction / Vickie S. Baselski -- Chapter 1.2 : Procedure Coding, Reimbursement, and Billing Compliance / Vickie S. Baselski -- Specimen Collection, Transport, and Acceptability -- Chapter 2.1 : Collection, Transport, and Manipulation of Clinical Specimens and Initial Laboratory Concerns / Andrea J. Linscott -- Aerobic Bacteriology -- Chapter 3.1 : Introduction / Deirdre L. Church -- Chapter 3.2 : Staining Procedures / Wilson W. Chan -- Chapter 3.3 : Processing, Isolation, Detection, and Interpretation of Aerobic Bacteriology Cultures / Deirdre L. Church -- Chapter 3.4 : Blood Cultures -- Chapter 3.5 : Body Fluid Cultures (Excluding Blood, Cerebrospinal Fluid, and Urine) / Richard B. Thomson -- Chapter 3.6 : Diagnosis of Catheter-Related Bloodstream Infection: Differential-Time-to-Positivity Cultures and Catheter Tip Cultures / Steve Miller -- Chapter 3.7 : Cerebrospinal Fluid Cultures / Deirdre L. Church -- Chapter 3.8 : Fecal and Other Gastrointestinal Cultures and Toxin Assays / Dylan R. Pillai -- Chapter 3.9 : Genital Cultures -- Chapter 3.10 : Ocular Cultures / Deirdre L. Church -- Chapter 3.11 : Respiratory Tract Cultures -- Chapter 3.12 : Urine Cultures / Wilson W. Chan -- Chapter 3.13 : Wound Cultures / Julie A. Carson -- Chapter 3.14 : Leptospira Culture / Paul N. Levett -- Chapter 3.15 : Detection of Human Mycoplasmas and Ureaplasmas from Clinical Specimens by Culture and PCR / Ken B. Waites, Lynn B. Duffy, Li Xiao -- Chapter 3.16 : Guidelines for Biochemical Identification of Aerobic Bacteria / Deirdre L. Church -- Chapter 3.17 : Biochemical Tests for the Identification of Aerobic Bacteria / Deirdre L. Church -- Chapter 3.18 : Identification of Gram-Positive Bacteria -- Anaerobic Bacteriology -- Chapter 4.1 : Introduction / Gerri S. Hall -- Chapter 4.2 : Collection, Transport, and Processing of Clinical Specimens for Anaerobic Culture / Gerri S. Hall, Judith Holden -- Chapter 4.3 : Culture Media for Anaerobes / Gerri S. Hall, James I. Mangels -- Chapter 4.4 : Incubation Techniques for Anaerobic Bacteriology Specimens / Gerri S. Hall, James I. Mangels -- Chapter 4.5 : Examination of Primary Culture Plates for Anaerobic Bacteria / Gerri S. Hall, Linda Byrd -- Chapter 4.6 : Rapid Disk, Spot Tests, and Other Rapid or Primary Methods for the Identification of Anaerobes / Gerri S. Hall, Paula Summanen -- Chapter 4.7 : Commercial Kit Overnight Biochemical Systems for the Identification of Anaerobes / Gerri S. Hall, James I. Mangels -- Chapter 4.8 : Rapid Enzymatic Systems for the Identification of Anaerobes / Gerri S. Hall, James I. Mangels -- Chapter 4.9 : Rapid Biochemical Tests (4 Hours or Less) for the Identification of Anaerobes / Gerri S. Hall, James I. Mangels -- Chapter 4.10 : Use of Matrix-Assisted Laser Desorption Ionization-Time of Flight for the Identification of Anaerobic Bacteria / Gerri S. Hall -- Chapter 4.11 : Anaerobic Gram-Negative Bacilli / Gerri S. Hall -- Chapter 4.12 : Anaerobic Gram-Positive Bacilli / Gerri S. Hall -- Chapter 4.13 : Anaerobic Cocci / Gerri S. Hall -- Chapter 4.14 : Suggestions for a Practical Scheme for the Workup of Anaerobic Cultures / Gerri S. Hall. Chapter 4.15 : Clostridium difficile as a Pathogen Involved in Antimicrobial Agent-Associated Diarrhea, Colitis, and Pseudomembranous Colitis / Gerri S. Hall -- VOLUME 2 -- Antimicrobial Susceptibility Testing -- Chapter 5.1 : Disk Diffusion Test -- Chapter 5.2 : Broth Microdilution Test -- Chapter 5.3 : Etest -- Chapter 5.4 : Agar Dilution MIC Test -- Chapter 5.5 : Beta-Lactamase Tests -- Chapter 5.6 : Oxacillin Salt-Agar Screen Test To Detect Oxacillin (Methicillin)-Resistant Staphylococcus aureus -- Chapter 5.7 : Detection of VRSA, VISA, and Vancomycin-Heteroresistant Staphylococcus aureus (hVISA) -- Chapter 5.8 : Screening Tests for Detection of High-Level Mupirocin Resistance in Staphylococcus aureus -- Chapter 5.9 : Detection of Inducible Clindamycin Resistance in Staphylococcus spp., Streptococcus pneumoniae, and Streptococcus spp. Beta-Hemolytic Group -- Chapter 5.10 : Screen Tests To Detect High-Level Aminoglycoside Resistance in Enterococcus spp. -- Chapter 5.11 : Agar Screen Test To Detect Vancomycin Resistance in Enterococcus spp. -- Chapter 5.12 : Extended-Spectrum Beta-Lactamase Testing for Escherichia coli, Klebsiella pneumoniae, Klebsiella oxytoca, and Proteus mirabilis -- Chapter 5.13 : The Modified Hodge Confirmatory Test (or the Carbapenem Inactivation Test) for Carbapenemase Production in Enterobacteriaceae -- Chapter 5.14 : 5.14 Tests To Assess Bactericidal Activity -- Chapter 5.15 : Serum Inhibitory and Bactericidal Titers -- Chapter 5.16 : Synergism Testing: Broth Microdilution Checkerboard and Broth Macrodilution Methods -- Chapter 5.17 : Quality Assurance Measures for Antimicrobial Susceptibility Testing -- Chapter 5.18 : Evaluation and Verification of Antimicrobial Susceptibility Test Systems -- Chapter 5.19 : Selecting Antimicrobial Agents for Testing and Reporting -- Chapter 5.20 : Preparation of Routine Media and Reagents Used in Antimicrobial Susceptibility Testing -- Chapter 5.21 : Preparation of Broth Microdilution MIC Trays -- Chapter 5.22 : Appendixes -- Aerobic Actinomycetes -- Chapter 6.1 : Introduction -- Chapter 6.2 : Specimen Examination and Primary Isolation -- Chapter 6.3 : Media and Methods Used for Phenotypic Characterization of Aerobic Actinomycetes -- Chapter 6.4 : Molecular Identification -- Chapter 6.5 : Susceptibility Testing -- Chapter 6.6 : Appendixes -- Mycobacteriology and Antimycobacterial Susceptibility Testing -- Chapter 7.1 : Introduction -- Chapter 7.2 : General Mycobacterial Procedures -- Chapter 7.3 : Solid Media Used for Isolation -- Chapter 7.4 : Liquid Media Used for Isolation -- Chapter 7.5 : Identification of Mycobacteria -- Chapter 7.6 : Nucleic Acid Amplification Procedures for Identification from Specimen -- Chapter 7.7 : Susceptibility Testing by Liquid Media Methods -- Chapter 7.8 : Susceptibility Testing by Agar Proportion Method for Mycobacterium tuberculosis Complex -- Chapter 7.9 : Susceptibility Testing by TREK Sensititre Microdilution Plates -- Mycology and Antifungal Susceptibility Testing -- Chapter 8.1 : Introduction and General Considerations -- Chapter 8.2 : Specimen Selection, Collection, and Transport -- Chapter 8.3 : Specimen Examination -- Chapter 8.4 : Processing Specimens for Fungal Culture -- Chapter 8.5 : Examination and Evaluation of Primary Cultures. Chapter 8.6 : Presumptive Identification Tests for Yeasts Isolated on Primary Culture -- Chapter 8.7 : Identification of Moulds on Primary Culture -- Chapter 8.8 : Full Identification of Yeasts -- Chapter 8.9 : Mould Identification -- Chapter 8.10 : Antifungal Susceptibility Testing -- Parasitology -- Chapter 9.1 : Introduction -- Chapter 9.2 : Collection and Preservation of Fecal Specimens -- Chapter 9.3 : Macroscopic and Microscopic Examination of Fecal Specimens -- Chapter 9.4 : Special Stains for Coccidia and Microsporidia -- Chapter 9.5 : Additional Techniques for Stool Examination -- Chapter 9.6 : Other Specimens from the Intestinal Tract and the Urogenital System -- Chapter 9.7 : Sputum, Aspirates, and Biopsy Material -- Chapter 9.8 : Detection of Blood Parasites -- Chapter 9.9 : Culture -- Chapter 9.10 : Appendixes -- Viruses and Chlamydiae -- Chapter 10.1 : Laboratory Diagnosis of Viral Infections: Introduction -- Chapter 10.2 : Selection, Maintenance, and Observation of Uninoculated Monolayer Cell Cultures -- Chapter 10.3 : Cell Culture Techniques: Serial Propagation and Maintenance of Monolayer Cell Cultures -- Chapter 10.4 : Specimen Collection and Processing -- Chapter 10.5 : Viral Culture: Isolation of Viruses in Cell Cultures -- Chapter 10.6 : Isolation of Chlamydia spp. in Cell Culture -- Chapter 10.7 : Direct Detection of Viruses and Chlamydia in Clinical Samples -- VOLUME 3 -- Immunology -- Chapter 11.1 : Immunology Introduction -- Chapter 11.2 : Serologic Diagnosis of Group A Streptococcal Infections -- Chapter 11.3 : Detection of Legionella Antigen by Direct Immunofluorescence -- Chapter 11.4 : Laboratory Diagnosis of Syphilis -- Chapter 11.5 : Detection of Borrelia burgdorferi Antibodies -- Chapter 11.6 : Serodiagnosis of Rickettsial Infections -- Chapter 11.7 : Virology Introduction -- Chapter 11.8 : Human Immunodeficiency Virus Serology -- Chapter 11.9 : Epstein-Barr Virus -- Chapter 11.10 : Cytomegalovirus Serology -- Chapter 11.11 : Herpes Simplex Virus 1 and 2 Serology -- Chapter 11.12 : Flow Cytometry -- Chapter 11.13 : Whole-Blood Lymphocyte Immunophenotyping Using Cell Surface Markers by Flow Cytometry -- Chapter 11.14 : Natural Killer Cell Assays -- Chapter 11.15 : Dendritic Cell Assays -- Chapter 11.16 : Neutrophil Assays -- Chapter 11.17 : Peripheral Blood Mononuclear Cells -- Chapter 11.18 : Lymphocyte Proliferation Assay -- Chapter 11.19 : Measurement of Antigen-Specific Cellular Responses Using the Polychromatic Flow Cytometry Intracellular Cytokine Staining Assay -- Chapter 11.20 : Interferon Gamma Enzyme-Linked Immunosorbent Spot Assay -- Chapter 11.21 : Bead- and Plate-Based Cytokine Enzyme-Linked Immunosorbent Assays -- Molecular Diagnostics -- Chapter 12.1 : Introduction -- Chapter 12.2 : General Aspects of Molecular Diagnostics -- Chapter 12.3 : Molecular Methods for Identification of Cultured Microorganisms -- Chapter 12.4 : Sequence-Based Identification and Typing -- Chapter 12.5 : Matrix-Assisted Laser Desorption Ionization Time of Flight (MALDI-TOF) for Microorganism Identification -- Chapter 12.6 : Appendix 12.6-1-FDA-Cleared or Approved Nucleic Acid-Based Tests -- Chapter 12.7 : Appendix 12.7-1-Location in CMPH4 of Molecular Procedures Outside of Section 12 -- Epidemiologic and Infection Control Microbiology. Chapter 13.1 : Introduction -- Chapter 13.2 : Laboratory Support for Infection Prevention: Collaboration with Benefits for All -- Chapter 13.3 : Environmental Sampling and Cultures -- Chapter 13.4 : Outbreak Investigations: Laboratory and Epidemiologic Concepts -- Chapter 13.5 : Microbial Strain Typing for Epidemiology and Infection Control -- Chapter 13.6 : Surveillance Cultures -- Chapter 13.7 : Infection Control in the Laboratory -- Quality Assurance, Quality Control, Laboratory Records, and Water Quality -- Chapter 14.1 : Quality Assessment and Improvement (Quality Assurance) -- Process Improvement -- Chapter 14.2 : Quality Control -- Chapter 14.3 : Laboratory Records -- Chapter 14.4 : Preparation and Quality Control of Laboratory Water -- Chapter 14.5 : Overview of Individualized Quality Control Plan (IQCP) -- Biohazards and Safety -- Chapter 15.1 : Introduction -- Chapter 15.2 : Biological Safety and Biohazard Prevention -- Chapter 15.3 : Biohazard Containment -- Chapter 15.4 : Laboratory Instrumentation and Equipment -- Chapter 15.5 : Special Pathogens and Employee Safety -- Chapter 15.6 : Packing and Shipping Infectious Substances -- Chapter 15.7 : Management of Laboratory Accidents -- Chapter 15.8 : Management of Infectious Waste -- Chapter 15.9 : Risk Assessment -- Bioterrorism -- Chapter 16.1 : General Introduction to Bioterrorism and Emerging Infectious Diseases -- Chapter 16.2 : Levels of Laboratory Safety -- Chapter 16.3 : Packing and Shipping Select Agents -- Chapter 16.4 : Anthrax-Bacillus anthracis -- Chapter 16.5 : Botulinum Toxin-Clostridium botulinum -- Chapter 16.6 : Brucellosis-Brucella spp. -- Chapter 16.7 : Plague-Yersinia pestis -- Chapter 16.8 : Tularemia-Francisella tularensis -- Chapter 16.9 : Melioidosis (Burkholderia pseudomallei) and Glanders (Burkholderia mallei) -- Chapter 16.10 : Smallpox-Variola Major -- Chapter 16.11 : Novel Influenza Viruses -- Chapter 16.12 : Q Fever-Coxiella burnetii -- Chapter 16.13 : Staphylococcal Enterotoxin B-Staphylococcus aureus -- Chapter 16.14 : Clinical Laboratory Bioterrorism Readiness Plan -- Chapter 16.15 : Biochemical Procedures -- Index.
  • Digital
    edited by Iqbal Ahmad, Mohammad Owais, Mohammed Shahid, Farrukh Aqil
    Digital : Springer2010
    "Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
  • Digital
    Yana Emmy Evangeline Hoy.
    Digital2011
    The importance of the intestinal microbiota to the health of an organism is well recognized. Alterations in the composition of the microbiota are associated with a number of diseases. However, the extent to which the microbiota varies across healthy individuals and time and the causes of this variation are still not fully understood. In order to distinguish between microbial community states of health and disease, the range of healthy microbial communities must be determined. In addition, the effect of perturbations on the microbiota is an area of active research. Recent studies indicate that intestinal infections can have a significant impact on the composition of intestinal microbiota. However, the extent and duration of these changes during different infections have not been fully characterized. My aims were to characterize the range of healthy microbiota in an inbred mouse population over time and to determine the dynamics of alterations in the microbiota during disease. I also wanted to determine if certain characteristics of the microbiota make animals more or less susceptible to infection. In this work, 46 individual healthy mice were sampled over time to assess the range of microbial communities in health. A mouse model of Salmonella enterica serovar Typhimurium infection was used to assess the impact of infection on the microbiota. Mice were sampled prior to infection and over the course of infection. This work finds that the microbiota of healthy mice varies significantly over time and among individuals. However, there are stable differences among individual mice, which may be established at the point of weaning when adult microbial communities develop. In addition, this work finds significant changes in the microbiota during infection that differ with the level of infection. This data also shows that there are some taxa whose abundance prior to infection correlates with outcome of infection. This work provides insights into the dynamics of the microbiota in health and disease and its impact on the health of the host.
  • Digital
    volume editor, Jessup M. Shively.
    Digital : Springer2006
  • Digital
    Saroj K. Mishra, Dipti Agrawal.
    Digital : Wiley2013
    Introduction -- Host-microbe interactions -- Antibiotics and other chemotherapeutic agents -- Antiseptics and disinfectants -- Gram-positive cocci -- Gram-positive bacilli -- Gram-positive bacteria with rudimentary filaments -- Gram-negative cocci -- Gram-negative bacilli -- Miscellaneous gram-negative bacteria -- Spirochetes and bacteria without a cell wall -- Actinomycetes -- Introduction to pathogenic fungi and superficial mycoses -- Subcutaneous and systemic mycoses -- Unicellular parasites -- Multicellular parasites -- Viruses and prions.
  • Digital
    Gabriele Halwachs-Baumann, editor.
    Digital : Springer2011
    Congenital cytomegalovirus (CMV) infection is the most common intrauterine transmitted viral infection, with a tremendous impact on fetuses and newborns. In this book the history of this disease, its pathophysiological background, epidemiology and symptoms, as well as diagnostic and therapeutic strategies, will be discussed. Since economic aspects are gaining more and more importance in health politics, one chapter is dedicated to this issue in the context of congenital CMV infection. The content is based on the latest scientific findings and written in an understandable manner, allowing persons not working in the field of congenital CMV to also profit from it. Thus, this book is of interest for medical doctors, nurses, midwives, economists, but also for men and women who want to inform themselves about this topic.
  • Digital
    Naomi Balaban, editor ; foreword by J. William Costerton.
    Digital : Springer2008
  • Digital
    edited by Helena Jane Maier, Erica Bickerton, Paul Britton.
    Digital : Springer Protocols2015
    Coronaviruses : an overview of their replication and pathogenesis / Anthony R. Fehr and Stanley Perlman -- Identification of a novel coronavirus from Guinea Fowl using metagenomics / Mariette F. Ducatez and Jean-Luc Guérin -- Serological diagnosis of feline coronavirus infection by immunochromatographic test / Tomomi Takano and Tsutomu Hohdatsu -- Estimation of evolutionary dynamics and selection pressure in coronaviruses / Muhammad Munir and Martí Cortey -- Preparation of chicken tracheal organ cultures for virus isolation, propagation, and titration / Ruth M. Hennion -- Preparation of chicken kidney cell cultures for virus propagation / Ruth M. Hennion and Gillian Hill -- Isolation and propagation of coronaviruses in embryonated eggs / James S. Guy -- Characterization of human coronaviruses on well- differentiated human airway epithelial cell cultures / Hulda R. Jonsdottir and Ronald Dijkman -- Quantification of infectious bronchitis coronavirus by titration in vitro and in ovo / Joeri Kint, Helena Jane Maier, and Erik Jagt -- Purification of coronavirus virions for Cryo-EM and proteomic analysis / Stuart Dent and Benjamin W. Neuman -- Partial purification of IBV and subsequent isolation of viral RNA for next-generation sequencing / Sarah M. Keep, Erica Bickerton, and Paul Britton -- Transient dominant selection for the modification and generation of recombinant infectious bronchitis coronaviruses / Sarah M. Keep, Erica Bickerton, and Paul Britton -- Engineering infectious cDNAs of coronavirus as bacterial artificial chromosomes / Fernando Almazán ... [et al.] -- Protein histochemistry using coronaviral spike proteins : studying binding profiles and sialic acid requirements for attachment to tissues / Iresha N. Ambepitiya Wickramasinghe and M. Hélène Verheije -- Identification of protein receptors for coronaviruses by mass spectrometry / V. Stalin Raj ... [et al.] -- Single particle tracking assay to study coronavirus membrane fusion / Deirdre A. Costello and Susan Daniel -- Studying coronavirus-host protein interactions / Chee-Hing Yang ... [et al.] -- Field-proven yeast two-hybrid protocol used to identify coronavirus-host protein-protein interactions / Pierre- Olivier Vidalain ... [et al.] -- Investigation of the functional roles of host cell proteins involved in coronavirus infection using highly specific and scalable RNA interference (RNAi) approach / Jean Kaoru Millet and Béatrice Nal -- Transcriptome analysis of feline infectious peritonitis virus infection / Parvaneh Mehrbod ... [et al.] -- Quantification of interferon signaling in avian cells / Joeri Kint and Maria Forlenza -- Studying the dynamics of coronavirus replicative structures / Marne C. Hagemeijer and Cornelis A. M. de Haan -- Preparation of cultured cells using high-pressure freezing and freeze substitution for subsequent 2D or 3D visualization in the transmission electron microscope / Philippa C. Hawes.
  • Digital
    Hideaki Yukawa, Masayuki Inui, editors.
    Digital : Springer2013
    Corynebacterium glutamicum was discovered in Japan in 1956 as a natural glutamate producer. Its "microbial factory" qualities, such as its physiological plasticity and robust catalytic functionalities, have since facilitated the development of efficient production processes for amino acids, nucleotides and vitamins. This monograph illustrates how the information gleaned from complete genome sequencing allows the rational engineering of the entire cellular metabolism and how systems biology permits the further optimization of C. glutamicum as a biocatalyst. Aspects of gene regulation, metabolic pathways, sugar uptake, protein secretion, cell division and biorefinery applications highlight the enormous biotechnological and biorefinery potential.
  • Print
    editors, Allen I. Laskin, Hubert A. Lechevalier.
    Status: Not Checked OutLane Catalog Record
    v. 1. Bacteria.--v. 2. Fungi, algae, protozoa, and viruses.--v. 3. Microbial composition : amino acids, proteins, and nucleic acids.--v. 4. Microbial composition : carbohydrates, lipids, and minerals.--v. 5. Microbial products.--v. 6. Growth and metabolism.--v. 7. Microbial transformation.--v. 8. Toxins and enzymes.--v. 9, pt. A. Antibiotics.
  • Digital
    Rodolphe Barrangou, John van der Oost, editors.
    Digital : Springer2013
    CRISPR-Cas is a recently discovered defense system which protects bacteria and archaea against invasion by mobile genetic elements such as viruses and plasmids. A wide spectrum of distinct CRISPR-Cas immune systems has been identified in at least half of the available prokaryotic genomes. On-going biochemical and functional analyses have resulted in substantial insight into the functions and possible applications of these fascinating systems, although many secrets remain to be uncovered. In this book, experts summarize the state of the art of this exciting field.
  • Digital
    edited by Andew Sails and Yi-Wei Tang.
    Digital : ScienceDirect2015
    Chapter 1. Total laboratory automation in clinical bacteriology -- Chapter 2. MALDI-TOF mass spectrometry for microorganism identification -- Chapter 3. POC tests in microbial diagnostics: current status -- Chapter 4. Molecular diagnostics in the diagnosis of parasitic infection -- Chapter 5. Clinical applications of quantitative real-time PCR in virology -- Chapter 6. Low-density TaqMan® array cards for the detection of pathogens -- Chapter 7. Invasive fungal infections and approaches to their diagnosis -- Chapter 8. Technical and software advances in bacterial pathogen typing -- Chapter 9. Molecular strain typing and characterisation of toxigenic Clostridium difficile -- Chapter 10. Accurate whole-genome sequencing-based epidemiological surveillance of Mycobacterium Tuberculosis -- Chapter 11. Solid and suspension microarrays for microbial diagnostics -- Chapter 12. Gene amplification and sequencing for bacterial identification -- Chapter 13. Host-based diagnostics for detection and prognosis of infectious diseases -- Chapter 14. MALDI-TOF mass spectrometry in the clinical microbiology laboratory: beyond identification -- Chapter 15. Next-generation sequencing for pathogen detection and identification -- Chapter 16. Virology: the next generation from digital PCR to single virion genomics -- Chapter 17. Artificial nucleic acid probes and their applications in clinical microbiology -- Index.
  • Digital
    editorial board, Richard Coico ... [et al.].
    Digital : Wiley2006-
    Emerging technologies -- Microscopy -- Alpha proteobacteria -- Beta proteobacteria -- Enteric gamma proteobacteria -- Nonenteric gamma proteobacteria -- Delta proteobacteria -- Epsilon proteobacteria -- Firmicutes (low G+C gram positive) -- Actinobacteria (high G+C gram positive) -- Chlamydiae -- Spirochetes -- Other eubacteria -- Animal DNA viruses -- Animal RNA viruses -- Plant RNA viruses.
  • Digital
    Digital : Springerv. 285-398, 2005-16.
  • Digital
    edited by Mark W. Robinson, John P. Dalton.
    Digital : Springer2011
    Print2011
    "Cysteine proteases expressed by pathogenic organisms play key roles in virulence including host entry, feeding and suppression of host immune responses. This book gives comprehensive coverage to all aspects of pathogen cysteine proteases and brings together numerous scientific advances which have been made over many years. Thus, the biochemistry, molecular biology and structure function relationships of these important pathogen enzymes are covered in detail. Written by leading researchers from Europe, Australia and North America, this book is essential reading for students and professionals interested in human medicine and infectious disease research"--Provided by publisher.
  • Digital
    edited by Randall T. Hayden, Donna M. Wolk, Karen C. Carroll, Yi-Wei Tang.
    Digital : Am Soc Microbiol2016
    I. Overview of infections in the immunocompromised host -- Overview of infections in the immunocompromised host / Lesia K. Dropulic and Howard M. Lederman -- II. Laboratory diagnosis: approaches, interpretations, and limitations : infections by specific etiologic agents -- Human immunodeficiency virus / Wendy S. Armstrong, Jeannette Guarner, Colleen S. Kraft, and Angela M. Caliendo -- Chronic hepatitis B, C, and D in the immunocompromised patient / Bryan R. Cobb and Alexandra Valsamakis -- Cytomegalovirus / Veronica Dioverti and Raymund R. Razonable -- Epstein-Barr infection in the immunocompromised host / Andrew Nowalk and Michael Green -- Herpes simplex virus and Varicella-Zoster virus / Myron J. Levin, Adriana Weinberg, and D. Scott Schmid -- Human herpesviruses 6A, 6B and 7 / Henri Agut, Pascale Bonnafous, and Agnes Gautheret-Dejean -- Human papillomavirus / Eileen M. Burd and Christina L. Dean -- Polyomaviruses / Linda Cook -- Adenovirus / Michael G. Ison and Randall T. Hayden -- Respiratory RNA viruses / Richard L. Hodinka -- Enteroviruses and parechoviruses / James J. Dunn -- Parvovirus B19 / Marie Louise Landry -- Filamentous fungi / Margaret V. Powers-Fletcher, Brian A. Kendall, Allen T. Griffin, and Kimberly E. Hanson -- Yeasts / Sean X. Zhang and Nathan P. Wiederhold -- Mycobacteria / Patricia J. Simner, Gail L. Woods, and Nancy L. Wengenack -- Aerobic actinomycetes of clinical significance / A. Brian Mochon, Den Sussland, and Michael A. Saubolle -- Parasites / Elitza S. Theel and Bobbi S. Pritt -- Aerobic bacteria and infections in the immunocompromised host / Geraldine Hall and Karen C. Carroll -- Selected topics in anaerobic bacteriology / Deirdre L. Church -- III. Laboratory diagnosis: approaches, interpretations and limitations : infections of specific organ systems -- Etiology, epidemiology and diagnosis of lower respiratory tract infections in immunocompromised patients / Karen C. Carroll and La'Tonzia L. Adams -- Genitourinary tract infections in immunocompromised patients / Odaliz Abreu Lanfranco and George J. Alangaden -- Gastrointestinal infections / Kevin Alby and Irving Nachamkin -- Central nervous system infections -- Andrea J. Zimmer, Victoria E. Burke, and Karen C. Bloch -- Bloodstream / Donna M. Wolk, Raquel M. Martinez, and Diana R. Hernandez -- Skin and soft tissue infection / Anne Spichler Moffarah, Mayar Al Mohajer, Bonnie L. Hurwitz, and David G. Armstrong -- IV. Special topics -- Prosthetic device infections / Raquel M. Martinez, Thomas R. Bowen, and Michael A. Foltzer -- Hospital-associated infections / Esther Babady -- Role of surgical pathologic diagnosis for immunocompromised hosts / Mary K. Klassen-Fischer and Ronald C. Neafie.
  • Digital
    edited by Ludwig Eichinger, Francisco Rivero.
    Digital : Springer Protocols2013
    Amoebozoa / Christina Schilde and Pauline Schaap -- Model organism Dictyostelium discoideum / Salvatore Bozzaro -- Comparative genomics of the dictyostelids / William F. Loomis -- One stop shop for everything Dictyostelium : dictyBase and the dicty stock center in 2012 / Petra Fey [and others] -- Fluorescent reporters and methods to analyze fluorescent signals / Annette Müller-Taubenberger and Hellen C. Ishikawa-Ankerhold -- Collection and cultivation of dictyostelids from the wild / Tracy E. Douglas [and others] -- Identification and verification of microRNAs by high-throughput sequencing / Jimmie Hällman [and others] -- Transcriptional profiling of Dictyostelium with RNA sequencing / Edward Roshan Miranda [and others] -- Analysis of chromatin organization by deep sequencing technologies / James L. Platt [and others] -- Pharmacogenetics of resistance to cisplatin and other anticancer drugs and the role of sphingolipid metabolism / Stephen Alexander, William S. Swatson, and Hannah Alexander -- N-glycomic and n-glycoproteomic studies in the social amoebae / Christa L. Feasley -- Measuring cheating, fitness, and segregation in Dictyostelium discoideum / Neil J. Buttery [and others] -- Application of the Cre-loxP system for generating multiple knock-out and knock-in targeted loci / Jan Faix [and others] -- Extrachromosomal inducible expression / Douwe M. Veltman and Peter J.M. Van Haastert -- Isolation of Dictyostelium nuclei for light and electron microscopy / Petros Batsios [and others] -- Investigation of DNA repair pathway activity / Anne-Marie C. Couto, Nicholas D. Lakin, and Catherine J. Pears -- Transcript localization in Dictyostelium discoideum cells by RNA FISH / Patrick Hofmann, Janis Kruse, and Christian Hammann -- Analysis of mitochondrial gene expression / Jessica E. Accari [and others] -- Mitochondrial respiratory complex function and the phenotypic consequences of dysfunction / Sarah J. Annesley [and others] -- Micropipette aspiration for studying cellular mechanosensory responses and mechanics / Yee-Seir Kee and Douglas N. Robinson -- Quantitative analysis of phagocytosis and phagosome maturation / Natascha Sattler, Roger Monroy, and Thierry Soldati -- Setting up and monitoring an infection of Dictyostelium discoideum with mycobacteria / Sonia Arafah [and others] -- Isolation of pathogen-containing vacuoles / Olga Shevchuk and Michael Steinert -- Immunomagnetic purification of fluorescent legionella-containing vacuoles / Ivo Finsel, Christine Hoffmann, and Hubert Hilbi -- Secretory lysosomes in Dictyostelium : visualization, characterization, and dynamics / Wanessa C. Lima and Pierre Cosson -- Monitoring autophagy in Dictyostelium / Ana Mesquita [and others].
  • Digital
    Kaitian Peng.
    Digital2011
    Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
  • Digital
    Vadrevu Sree Hari Rao, Ponnada Raja Sekhara Rao.
    Digital : Springer2009
    Basic models -- Chemostat versus the lake -- Instability tendencies -- Self-regulation -- Wall growth -- Zones of no activation -- Influence of the control mechanisms -- Parameter estimation using dynamic optimization.
  • Digital
    Abdelhamid Ajbar, Khalid Alhumaizi.
    Digital : CRCnetBASE2012
    1. Introduction to stability of bioreactors -- 2. Introduction to bioreactors models -- 3. Introduction to stability and bifurcation theory -- 4. The basic model of ideal chemostat -- 5. The chemostat with wall attachment -- 6. Pure and simple microbial competition -- 7. Stability of continuous recombinant DNA cultures -- 8. Biodegradation of mixed substrates -- 9. Predator-prey interactions -- 10. Ratio-dependent models -- 11. Models with product formation -- 12. Models with product formation : type II models -- 13. Models with product formation : type III models -- 14. Operability of nonideal bioreactors -- 15. Operability of prefermentation of cheese culture -- 16. Biodegradation of wastewater -- 17. Dynamics of activated sludge reactors -- 18. Complex dynamics in forced bioreactors.
  • Digital
    Stephen M. King.
    Digital : ScienceDirect2012
    Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over one hundred streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. . Broad-based up-to-date resource for the dynein class of molecular motors . Chapters written by world experts in their topics . Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features.
  • Digital
    Lori Frappier.
    Digital : Springer2013
    Introduction -- Roles of EBNA1 at EBV Episomes -- EBNA1-DNA Interactions -- EBNA1 Contributions to EBV-Associated Tumours -- Cellular Effects of EBNA1 -- Conclusion.
  • Digital
    Katie Marie Shelef.
    Digital2013
    Recent work on the human microbiome represents the essence of community ecology: "What makes assemblages of species more or less similar to each other at different places and times?" (Vellend 2010; Anderson et al. 2011). The complex microbial communities of the human subgingival crevice are particularly relevant since multiple, spatially distinct but ecologically similar sites are found in a single subject. Healthy sites and sites affected by periodontitis (gum disease) can coexist in the same mouth simultaneously; periodontal disease may reflect community processes since it is thought to have a polymicrobial etiology rather than a single species etiology in the tradition of Koch's postulates. Subgingival communities therefore provide a unique, clinically relevant context to apply ecological concepts. The goal of this work was to advance our ecological understanding of the human subgingival microbiota, drawing on two fields of ecological research: biogeography and the stability of complex communities. The first half of this work explored oral biogeography and treating subgingival sites as isolated, island-like patches of similar habitat distributed within a mouth. A survey of twenty-three to thirty subgingival sites per mouth within five periodontally healthy subjects uncovered non-random, spatially relevant patterns of community distributions. Specifically, a left-right symmetric pattern of community similarity and a positive correlation between physical distance between sites and the dissimilarity of their respective communities were observed. However, these patterns were only discernable among deeply sequenced communities. Additional applications of co-occurrence analysis and neutral theory models to the data indicated that both competitive interactions and stochastic, demographic processes influence distributions of subgingival taxa. The second half of this work assessed the temporal stability of health and periodontitis-associated subgingival and salivary microbial communities before and after a single disturbance event of professional teeth cleaning. Communities were surveyed in 8 subjects (4 healthy, 4 with moderate chronic periodontitis), at 4 sites per subject, and at four sampling times ranging from 2 weeks to 1 day before the cleaning to assess baseline spatial and temporal variation. Samples collected at seven time points ranging from 1 hour to 3 months after the cleaning were also examined in order to monitor the compositional response to the perturbation. The results of this work demonstrated that healthy and periodontitis-associated subgingival communities are resilient to a teeth-cleaning perturbation, but the displacement of community composition immediately after cleaning was greater in periodontitis than in health. Periodontitis-associated subgingival communities more closely resembled a health-like composition as they recovered from the cleaning, although this change was transient. Salivary communities were also shown to be resilient to a teeth cleaning perturbation, but the impact of the cleaning on community composition is less pronounced in saliva. The results further suggest that post-cleaning residual subgingival communities contribute more to subgingival recolonization than salivary communities. The results of this work generated testable hypotheses about the ecological mechanisms governing observed spatial and temporal patterns. I hope these findings will contribute to the development of novel, ecologically informed approaches to the clinical treatment of the subgingival environment.
  • Digital
    by John R. Crowther.
    Digital : Springer Protocols2009
  • Digital
    Anjali Joshi Shastri.
    Digital2013
    The ubiquitous parasite Toxoplasma gondii has developed an exquisite arsenal of effectors to support its intracellular lifestyle and its persistence within its diverse hosts. In order to survive and resist clearance, this obligate intracellular parasite must contend with the host immune response. Different strains of the parasite vary dramatically in their interaction with the immune system, and studying these strain differences has furthered our understanding of the spectrum of host-pathogen interactions and led to the identification of parasite effectors. The work described here dissects the interactions between different strains of the parasite and host macrophages: innate immune cells that paradoxically both serve as a niche for parasite replication and defend the host against parasite infection. Chapter 1 introduces Toxoplasma, the immune response to infection, and discusses the role of known parasite effectors. Experiments described in Chapter 2 identify a novel secreted parasite factor, GRA25, which modulates cytokine secretion in macrophages and controls parasite virulence in mice. In Chapter 3, high throughput methods are used to characterize the transcriptional and phosphorylation landscape of macrophages infected with different Toxoplasma strains. These analyses demonstrate that a secreted polymorphic tyrosine kinase, ROP16, directs murine macrophage polarization towards an alternatively activated phenotype. They also reveal that Toxoplasma parasites activate the Type I interferon response, a response classically associated with cytosolic pathogens. Chapter 4 describes work demonstrating that Toxoplasma strain-specifically modulates the innate immune response via secretion of a parasite factor, MAF1, which recruits host mitochondria to the parasitophorous vacuole. Finally, Chapter 5 discusses the future directions and implications of this work in the broader context of host-pathogen interactions.
  • Digital
    Digital : Wiley1999-
    A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.
  • Digital
    editor-in-chief, Moselio Schaechter.
    Digital : ScienceDirect2009
    Subject Classification: -- Applied Microbiology: Agro/Food -- Applied Microbiology: Industrial -- Archaea -- Bacteria -- Cell Structure Chemical Composition -- Environmental Microbiology and Ecology -- Evolution and Systematics -- Fungi -- Genetics, Genomics -- History and Culture, (and Biographies) -- Mutualism and Commensalism -- Pathogenesis -- Physiology -- Protists -- Public Issues -- Techniques -- Viruses.
  • Digital
    Johannes H.P. Hackstein, editor.
    Digital : Springer2010
    Free-Living Protozoa with Endosymbiotic Methanogens / Tom Fenchel and Bland J. Finlay -- Anaerobic Ciliates and Their Methanogenic Endosymbionts / Johannes H. P. Hackstein -- Symbiotic Methanogens and Rumen Ciliates / Kazunari Ushida -- The Methanogenic and Eubacterial Endosymbionts of Trimyema / Naoya Shinzato and Yoichi Kamagata -- Termite Gut Flagellates and Their Methanogenic and Eubacterial Symbionts / Yuichi Hongoh and Moriya Ohkuma -- Methanogens in the Digestive Tract of Termites / Andreas Brune -- Methanogenic Archaea in Humans and Other Vertebrates / Everly Conway de Macario and Alberto J. L. Macario -- Methanogens in the Gastro-Intestinal Tract of Animals / Johannes H. P. Hackstein and Theo A. van Alen -- Syntrophy in Methanogenic Degradation / Petra Worm, Nicolai Müller, Caroline M. Plugge, Alfons J. M. Stams and Bernhard Schink -- Hydrogenosomes / Johannes H. P. Hackstein and Aloysius G. M. Tielens -- Evolution of Prokaryote-Animal Symbiosis from a Genomics Perspective / Rosario Gil, Amparo Latorre and Andrés Moya.
  • Digital
    Friedrich Koch-Nolte, editor.
    Digital : Springer2015
    Part I. Evolution and detection of endogenous ADP-ribosylation. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system / L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer -- Identification and analysis of ADP-ribosylated proteins / Friedrich Haag and Friedrich Buck -- Part II. ADP-ribosylation by ARTCs (R-S-E ARTs). Photorhabdus luminescens Toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine / Klaus Aktories, Gudula Schmidt and Alexander E. Lang -- Reaction mechanism of mno-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein / Hideaki Tsuge and Toshiharu Tsurumura -- Regulation of nitrogenase by reversible mono-ADP-ribosylation / Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells / Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte and Sahil Adriouch -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish / Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto and Masahiko Watanabe -- Part III. ADP-ribosylation by ARTDs (H-Y-E ARTs). Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family / Ana Filipa Pinto and Herwig Schüler -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 / Max Kaufmann, Karla L.H. Feijs and Bernhard Lüscher -- Regulation of nucleocytoplasmic transport by ADP-tibosylation: the emerging role of Karyopherin-[Beta]1 mono-ADP-ribosylation by ARTD15 / Maria Di Girolamo -- Index.
  • Digital
    David Halladin.
    Digital2013
    This thesis examines three topics that are related to the Gram-positive bacterial cell envelope. First, I examine how transmembrane proteins navigate through the thick, heavily cross-linked Gram-positive cell wall while remaining anchored to the bacterial membrane. I develop a theoretical model that predicts that entropic confinement of a disordered protein can drive translocation through the cell wall. I experimentally test important predictions of the model to demonstrate that translocation depends on the length of the translocating protein and the geometry of the bacterial surface, while demonstrating that entropy-driven translocation occurs in a variety of Gram-positive species. Second, I study how the antimicrobial peptide nisin causes cell death in Gram-positive bacteria. I demonstrate that nisin treatment triggers membrane collapse in multiple Gram-positive species, and provide evidence that collapse is initiated by an increase in compressive stress in the membrane. Finally, I examine the process of cell division in the Gram-positive coccus Staphylococcus aureus. Contrary to the current view of S. aureus division, cell volume increases monotonically during the cell cycle, as opposed to occurring entirely during cell separation. I observed a dramatic millisecond hemisphere-to-sphere transition during cell separation that was accompanied by a decrease in surface area, suggesting that separation is associated with a redistribution of cell wall stress.
  • Digital
    volume editors, C.P. Kubicek, I.S. Druzhinina.
    Digital : Springer2007
  • Digital
    edited by Jared R. Leadbetter.
    Digital : ScienceDirect2005
    Print2005
    Cultivation -- Physiological ecology -- Nucleic acid techniques.
  • Digital
    edited by Ian T. Paulsen, Andrew J. Holmes.
    Digital : Springer Protocols2014
    Methods for isolation and cultivation of filamentous fungi / Helena Nevalainen, Liisa Kautto, and Junior Te'o -- Rapid extraction of PCR-competent DNA from recalcitrant environmental samples / Michael R. Gillings -- Quantitative PCR for detection of mRNA and gDNA in environmental isolates / Anthony J. Brzoska and Karl A. Hassan -- Analysis of community dynamics in environmental samples using denaturing gradient gel electrophoresis / Claire L. Thompson -- Terminal restriction fragment length polymorphism (T-RFLP) profiling of bacterial 16S rRNA genes / Catherine A. Osborne -- Profiling the diversity of microbial communities with single-strand conformation polymorphism (SSCP) / Achim Schmalenberger and Christoph C. Tebbe -- Human fecal source identification with real-time quantitative PCR / Orin C. Shanks ... [and 4 others] -- Next generation barcode tagged sequencing for monitoring microbial community dynamics / Katy Breakwell, Sasha G. Tetu, and Liam D.H. Elbourne -- Analysis of methanotroph community structure using a pmoA-based microarray / Guy C.J. Abell ... [and 3 others] -- Biolog Phenotype MicroArrays for phenotypic characterization of microbial cells / Amanda M. Mackie ... [and 3 others] -- Visualization of metabolic properties of bacterial cells using nanoscale secondary ion mass spectrometry (NanoSIMS) / Yi Vee Chew, Andrew J. Holmes, and John B. Cliff -- Single-cell Raman sorting / Mengqiu Li ... [and 3 others] -- Bacterial whole-cell biosensors for the detection of contaminants in water and soils / Yun Wang ... [and 3 others] -- Stable isotope probing to study functional components of complex microbial ecosystems / Sophie Mazard and Hendrik Schäfer -- Metagenomics using next-generation sequencing / Lauren Bragg and Gene W. Tyson -- Targeted genomics of flow cytometrically sorted cultured and uncultured microbial groups / Sophie Mazard ... [and 4 others] -- Quantitative microbial metatranscriptomics / Scott Gifford, Brandon Satinsky, and Mary Ann Moran -- Quantitative metaproteomics : functional insights into microbial communities / Chongle Pan and Jillian F. Banfield.
  • Digital
    Carol A. Kauffman, Peter G. Pappas, Jack D. Sobel, William E. Dismukes, editors.
    Digital : Springer2011
    "Clinical Mycology" offers a comprehensive review of this discipline. Organized by types of fungi, this volume covers microbiologic, epidemiologic and demographic aspects of fungal infections as well as diagnostic, clinical, therapeutic, and preventive approaches. Special patient populations are also detailed.
  • Digital
    World Health Organization, Food and Agriculture Organization of the United Nations.
    Digital : WHO2008
    Print2008
    Exposure assessment is one of the four steps of microbiological risk assessment. This volume provides guidelines for the exposure assessment of microbiological hazards in food. It outlines the principles of exposure assessment as well as the data needed and approaches available for carrying out exposure assessment.--Publisher's description.
  • Digital
    edited by Fred A. Rainey and Aharon Oren.
    Digital : ScienceDirect2007
    Print2006
  • Digital
    Sikha Mandal, Jnanendra Rath.
    Digital : Springer2015
    This volume presents recent developments in the novel drug development and potential of extremophilic cyanobacteria. It discusses how these tiny organism originated, produce oxygen that leads to evolution of life on the earth, how their survival strategies in extreme climatic conditions lead to diverse metabolic pathways, and the opportunity to use them to develop novel drugs. The book is comprised of five chapters, starting with the origin of cyanobacteria, their survival strategies under extreme conditions, and their capabilities to change metabolic activities.The second chapter explores the different metabolic pathways found in cyanobacteria and examines advances in this field and recent techniques like MALDI-TOF imaging and metagenomics tools as well as in silico techniques for rapid screening of secondary metabolites. Further chapters cover the glycomics of cyanobacteria, anticancer drug development, and some issues and challenges of using cyanobacteria to develop drugs. Extremophilic Cyanobacteria For Novel Drug Development provides insight into future perspectives in drug development and is a key resource for students, researchers and professionals in pharmacy, medicinal chemistry, pharmacognosy biotechnology, biology, and academics.
  • Digital
    [edited by] Harald Wajant.
    Digital : Springer2006
    FasL and Fas: typical members of the TNF ligand and receptor family / Anja Krippner-Heidenreich and Peter Scheurich -- FasL-independent activation of Fas / Faustino Mollinedo and Consuelo Gajate -- Role of ceramide in CD95 signaling / Volker Teichgräber, Gabriele Hessler and Erich Gulbins -- Regulation of Fas signaling by FLIP proteins / Margot Thome -- Fas-induced necrosis / Tom Vanden Berghe ... [et al.] -- Fas - more than an apoptosis inducer / Harald Wajant -- Retrograde Fas ligand signaling -- FasL and Fas in liver homeostasis and hepatic injuries -- Fas-activation, development and homeostasis of T cells / Georg Häcker -- The FasL-Fas system in disease and therapy -- Tools for activation and neutralization of Fas signaling.
  • Digital
    Marc Daëron, Falk Nimmerjahn, editors.
    Digital : Springer2014
    This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
  • Digital
    Essam Kotb.
    Digital : Springer2012
  • Digital
    edited by E. Velázquez and C. Rodriguez-Barrueco.
    Digital : Springer2007
  • Digital
    edited by Catherine Adley.
    Digital : Springer Protocols2006
    Detection of hemolysins in Aeromonas spp. isolates from food sources / Rosabel Falcón ... [et al.] -- Detection and purification of Bacillus cereus enterotoxins / Toril Lindbäck and Per Einar Granum -- Campylobacter / Rachel Gorman and Catherine C. Adley -- Detection of Clostridium botulinum by multiplex PCR in foods and feces / Miia Lindström, Mari Nevas, and Hannu Korkeala -- Multiplex PCR for the specific identification of enterohemorrhagic Escherichia coli strains in the O157:H7 complex / Peter C.H. Feng and Steven R. Monday -- Pulsenet's step-by-step laboratory protocol for molecular subtyping of Listeria monocytogenes by macrorestriction and pulsed-field gel electrophoresis / Lewis M. Graves and Balasubramanian Swaminathan -- Plesiomonas shigelloides / Ivan Ciznar ... [et al.] -- Pulsed-field gel electrophoresis as a molecular technique in Salmonella epidemiological studies / Rachel Gorman and Catherine C. Adley -- Kits for the detection of food poisoning toxins produced by Bacillus cereus and Staphylococcus aureus / Moira M. Brett -- Microbiological and molecular methods to identify and characterize toxigenic Vibrio cholerae from food samples / Keya De, Ranjan K. Nandy, and G. Balakrish Nair -- HPLC measurement of aflatoxin B1 and metabolites in isolated rat hepatocytes / Jennifer Colford -- Detection of noroviruses of genogroups I and II in drinking water by real-time one-step rRT-PCR / Christian M. Beuret -- Detection of enteroviruses / Miguel-Angel Jiménez-Clavero ... [et al.] -- Detection of hepatitis A virus and rotavirus using nucleic acid sequence-based amplification / Julie Jean and Ismaïl Fliss -- Isolation and characterization of cathepsin-L1 protease from Fasciola hepatica excretory/secretory products for the serodiagnosis of human fasciolosis / Sandra O'Neill, Grace Mulcahy, and John Dalton -- Molecular biology methods for detection and identification of Cryptososporidium species in feces, water and shellfish / C.J.P. Lowery ... [et al.] -- Molecular identification of nematode worms from seafood (Anisakis spp. and Pseudoterranova spp.) and meat (Trichinella spp.) / Giuseppe La Rosa, Stefano D'Amelio, and Eduardo Pozio -- Approaches to developing quantitative risk assessment models / Enda J. Cummins -- A review of surveillance networks of food-borne diseases / Camelia Molnar, Rita Wels, and Catherine C. Adley.
  • Digital
    edited by Michael P. Doyle, Robert L. Buchanan.
    Digital : Am Soc Microbiol2013
    Factors of special significance to food microbiology -- Microbial spoilage and public health concerns -- Foodborne pathogenic bacteria -- Nonbacterial pathogens -- Preservatives and preservation methods -- Fermentations and beneficial microorganisms -- Advanced techniques in food microbiology.
  • Digital
    edited by Jan Dijksterhuis, Robert A. Samson.
    Digital : CRCnetBASE2007
  • Digital
    edited by Yanbo Wang, Wangang Zhang, Linglin Fu.
    Digital : CRCnetBASE2017
    Spoilage microorganisms in cereal products / Wenjian Yang, Dapeng Li, and Alfred Mugambi Mariga -- Spoilage microorganisms in bean products / Hui Zhou, Yun Tian, and Rongrong Wang -- Spoilage microorganisms in fruit product / Liang Gong, Yueming Jiang, and Xuewu Duan -- Spoilage microorganisms in vegetables / Tianjia Jiang, Hangjun Chen, Haiyan Gao, Zhiqin Zhou -- Spoilage microorganisms in meat products / Wangang Zhang and Yimin Zhang -- Spoilage microorganisms in poultry products / Qiuqin Zhang, Jinxuan Cao, Lingzhi Cheong -- Spoilage microorganisms in sea food products / Feifei Wang, Junda Lin, Deqing Zhou, Yan Zhang, Qing Gu, Yanbo Wang, Linglin Fu -- Spoilage microorganisms in powdered milk / Yingwang Ye -- Spoilage microorganisms in egg products / Hammad Hamed Hammad Mohammed, Putri Widyanti Harlina, Shugang Li, and Yongguo Jin.
  • Digital
    edited by Shabbir Simjee ; foreword by Toni L. Poole.
    Digital : Springer2007
    Escherichia coli / Jianghong Meng and Carl M. Schroeder -- Listeria / Franz Allerberger -- Clostridium botulinum and Clostridium perfringens / Jim McLauchlin and Kathie A. Grant -- Yersinia enterocolitica and Yersinia pseudotuberculosis / Maria Fredriksson-Ahomaa -- Foodborne pathogenic vibrios / T. Ramamurthy and G. Balakrish Nair -- Enterococcus and its association with foodborne illness / Simona F. Oprea and Marcus J. Zervos -- Foodborne viral hepatitis / Hazel Appleton ... [et al.] -- Gastroenteric virus / Miren Iturriza-Gómara, Chris I. Gallimore, and Jim Gray -- Cryptosporidium / Huw V. Smith -- Toxoplasma gondii / Dolores E. Hill ... [et al.] -- Aflatoxins : background, toxicology, and molecular biology / Joan W. Bennett, S. Kale, and Jiujiang Yu -- Scombroid fish poisoning / Elijah W. Stommel -- Pathogen control in meat and poultry production: implementing the USDA food safety and inspection service's hazard analysis and critical control point system / Moshe S. Dreyfuss ... [et al.] -- Use of antimicrobials in food animal production / Frank M. Aaestrup and Lars B. Jensen -- Alternatives to antimicrobials* / Toni L. Poole, Todd R. Callaway, and David J. Nisbet -- Microbial risk assessment / Carl M. Schroeder -- Food irradiation and other sanitation procedures / Donald W. Thayer -- Molecular techniques of detection and discrimination of foodborne pathogens and their toxins / Steven L. Foley and Kathie A. Grant -- Future directions in food safety* / Ross C. Beier and Suresh D. Pillai.
  • Digital
    Arun K. Bhunia.
    Digital : Springer2008
  • Digital
    edited by Om V. Singh.
    Digital : Wiley2017

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Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

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MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

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Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

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