Lane Medical Library

Books by Subject

Microbiology

  • Digital
    edited by William Olds.
    CRCnetBASE2015
    Part 1. Introduction : the rainforest in the gut -- part 2. Microbiome's role in obesity -- part 3. Inflammation and innate immunity -- part 4. Nutrition's effect on the microbiome -- part 5. Using the microbiome to identify and cure disease.
  • Digital
    Shumin Tan.
    Helicobacter pylori is a bacterium that chronically infects the stomachs of more than half the human population, in some cases leading to serious diseases such as gastric cancer and ulcers. H. pylori intimately interact with the gastric epithelial surface, but much remains unknown about its life on the cell surface. The bacterium possesses several tools for its close interaction with the gastric epithelia, including a type IV secretion system, through which the virulence factor CagA is directly translocated into host cells. This dissertation focuses on how H. pylori's close interactions with the epithelial cells allows it to modify the apical cell surface to turn it into a replicative niche for the bacterium. Using live-cell microscopy to follow the fate of individual bacteria on the cell surface, we find that H. pylori is able to utilize the apical cell surface as a replicative niche, even in conditions that do not support the growth of free-swimming bacteria. Experiments with a polarized epithelial model system show that the bacterium's major virulence factors CagA and VacA both play important roles in enabling H. pylori growth and microcolony formation on the apical cell surface, by mediating perturbation of host cell polarity and intracellular trafficking processes. We find that iron is one important micronutrient that H. pylori acquires from host cells during colonization of the polarized epithelium. CagA and VacA act in concert to affect the polarized process of transferrin/transferrin receptor recycling and iron uptake in the host cells, resulting in the mis-sorting of a subset of the transferrin/transferrin receptor complex to the colonizing bacteria on the apical cell surface. This process is functionally important for the bacteria, as downregulation of transferrin receptor expression resulted in a decreased ability of H. pylori to colonize the polarized epithelium. These studies establish the cell surface as a replicative niche, which presents challenges that require bacterial adaptation for its successful utilization. Our findings also illustrate the concept that contact-dependent bacterial virulence factors may be used for the perturbation of host cell physiology for the bacterium's benefit, allowing acquisition of needed factors directly from host cells, and colonization of the apical cell surface.
  • Digital
    edited by JeanMarie Houghton.
    Springer Protocols2012
    Introduction / JeanMarie Houghton -- Helicobacter pylori: an overview / Jennifer M. Noto, Richard M. Peek -- Perspectives on methodology for in vitro culture of Helicobacter pylori / Timothy L. Cover -- Successful culture techniques for Helicobacter species : general culture techniques for Helicobacter pylori / Jeannette M. Whitmire, D. Scott Merrell -- Successful culture techniques for Helicobacter species: establishing H. pylori cultures from infected rodents / Jeannette M. Whitmire, D. Scott Merrell -- Successful culture techniques for Helicobacter species: verification of Helicobacter identity using 16s rRNA gene sequence analysis / Jeannette M. Whitmire, D. Scott Merrell -- The Helicobacter pylori cag pathogenicity island / Jennifer M. Noto, Richard M. Peek -- Genetic manipulation of a naturally competent bacterium, Helicobacter pylori / Jennifer M. Noto, Richard M. Peek -- A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori / Marina Leite, Ceu Figueiredo -- Cell culture-based assays to test for bacterial adherence and internalization / Deepa Raju, David Rizzuti, Nicola L. Jones -- Cell culture assays to evaluate bacterial toxicity and virulence / Deepa Raju, David Rizzuti, Nicola L. Jones -- Rodent models of Helicobacter infection, inflammation and disease / Songhua Zhang, Steven F. Moss -- Bacterial culture and inoculation of mice (simple infection) / Brian M. Gray, Kathryn A. Eaton -- Adoptive transfer of splenocytes to immunocompromised mice / Brian M. Gray, Kathryn A. Eaton -- Isolation of gastric lamina propria leukocytes / Brian M. Gray, Kathryn A. Eaton -- Delayed-type hypersensitivity determination / Brian M. Gray, Kathryn A. Eaton -- Necropsy, blood, tissue collection and mRNA isolation for detection of host cytokine gene expression / Brian M. Gray, Kathryn A. Eaton -- Animal models of Helicobacter-induced disease: methods to successfully infect the mouse / Nancy S. Taylor, James G. Fox -- Verifying and quantifying Helicobacter pylori infection status of research mice / Mark T Whary, Zhongming Ge, James G. Fox -- Mouse models of Helicobacter-induced gastric cancer: use of cocarcinognes / Richard L. Ferrero, John E. Wilson, Phil Sutton -- Gastric Helicobacter spp. in animal models: pathogenesis and modulation by extragastric coinfections / Arlin B. Rogers -- Histologic scoring of gastritis and gastric cancer in mouse models / Arlin B. Rogers -- Innate immune responses to Helicobacter pylori infection: an overview / Milan K. Patel, Melanie I. Trombly, Evelyn A. Kurt-Jones -- Methods for in vivo and in vitro analysis of innate immune responses to Helicobacter pylori infection / Milan K. Patel [and others] -- Techniques for following labeled cells in vivo: use of X/Y FISH, techniques to optimize fluorescent detection, and beta-galactosidase detection / Michael Craig, Michael Schumacher, Yana Zavros -- In vivo measurement of Helicobacter pylori infection / Marjan Mohammadi [and others].
  • Digital
    Benhur Lee, Paul A. Rota, editors.
    Springer2012
    Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K. T. Wong and C. T. Tan -- Henipaviruses in Their Natural Animal Hosts / D. J. Middleton and H. M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
  • Digital
    edited by Ralf Bartenschlager.
    Springer2013
    Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
  • Digital
    Moshe Oren, Yael Aylon, editors.
    Springer2013
    The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.
  • Digital
    Thomas J. Inzana, editor.
    Springer2016
    Taxonomy of Histophilus somni -- Histophilosis as a Natural Disease -- Histophilus somni Genomics and Genetics -- Interactions on Histophilus somni with Host Cells -- Histophilus somni Surface Proteins -- Host Immune Response to Histophilus somni -- The Many Facets of Lipooligosaccharide as a Virulence Factor of Histophilus somni -- Exopolysaccharide Production and Biofilm Formation by Histophilus somni.
  • Digital
    Josephine Y. Lee.
    Helicobacter pylori is a human specific pathogen that chronically infects the stomachs of over half of the world's population. Infection with H. pylori strains expressing the virulence factor, CagA, greatly increases the risk of developing gastric cancer, although only a subset of infected individuals develop severe disease. It is therefore important to define factors that contribute to disease progression in the context of H. pylori infection. This body of work began with developing a CagA+ mouse model in which both H. pylori and mouse genetics can be used to study disease development. Using this system, we have identified three novel factors that influence disease progression. Two months after oral infection, mice develop precancerous lesions such as mucous metaplasia. However, animals infected as neonates are protected from developing lesions compared to mice infected as adults, suggesting that the age of infection is an important risk factor for disease development. Using 3D confocal microscopy, we discovered that H. pylori preferentially colonizes gastric glands in the antrum of the stomach. A chemotaxis mutant that is unable to properly sense and respond to its environment can colonize the surface of the stomach but fails to colonize the mid-gastric glands. Development of pathology is reduced in animals infected with the chemotaxis mutant, indicating that bacterial factors that affect localization of H. pylori within the glands is important for disease progression. Surprisingly, we discovered that the severity of pathology in genetically identical C57BL/6 mice from two different vendors is dramatically different. Mice from one vendor develop an antrum-dominant infection and inflammation, but fail to develop precancerous lesions. Mice from the second vendor develop precancerous lesions, and the infection and inflammatory response are distributed throughout the stomach. Our findings align with disease progression observed in human infection with H. pylori, in which an antrum-dominant gastritis is protective against cancerous lesions and pan-gastritis is associated with gastric cancer development. We suspected that the gut microbiota is an environmental factor that influences differences in H. pylori localization and host pathology. By co-housing animals from the two vendors or perturbing the flora with antibiotics prior to infection with H. pylori, we found that both bacterial localization and pathology could be shifted to the corpus in the animals from the first vendor, suggesting that the microbiota may influence H. pylori localization and disease progression. Since mice from second vendor had a dominant phenotype in the co-housing experiments, we compared the gut microbiota composition of the animals by sequencing fecal samples obtained before and after co-housing. The microbiota of the animals from the two vendors were different prior to co-housing, but after co-housing, the microbiota of both groups was similar to the animals from the second vendor. These findings support the observation that mice from the first vendor phenocopy mice from the second vendor after co-housing. We are currently identifying specific components of the microbiota that may be responsible for shifting the phenotype. Analysis of differences in the immune response of animals from the two vendors suggest that the microbiota may shift the immune balance in response to H. pylori infection and lead to differential disease outcomes. Using our mouse model of infection, we have identified novel host, bacterial and environmental factors that contribute to H. pylori-induced disease progression.
  • Digital
    edited by Alexandra C. Brand, Donna M. MacCallum.
    Springer Protocols2012
    Gene deletion in Candida albicans wild-type strains using the SAT1-flipping strategy -- Mini-blaster-mediated targeted gene disruption and marker complementation in Candida albicans -- Rapid detection of aneuploidy following the generation of mutants in Candida albicans -- Agrobacterium-mediated insertional mutagenesis in histoplasma capsulatum -- Targeted gene disruption in cryptococcus neoformans using double-joint PCR with split dominant selectable markers -- Multiple gene deletion in cryptococcus neoformans using the cre-lox system -- Gene disruption in aspergillus fumigatus using a PCR-based strategy and in vivo recombination in yeast -- Targeted gene deletion in aspergillus fumigatus using the hygromycin-resistance split-marker approach -- Gene disruption in coccidioides using hygromycin or phleomycin resistance markers -- RNAi-based gene silencing using a GFP sentinel system in histoplasma capsulatum -- RNA interference in cryptococcus neoformans -- Gene knockdown in paracoccidioides brasiliensis using antisense RNA -- Tetracycline-inducible gene expression in Candida albicans -- Galactose-inducible promoters in cryptococcus neoformans var. Grubii -- Modular gene over-expression strategies for Candida albicans -- Interactions between macrophages and cell wall oligosaccharides of Candida albicans -- Murine bone marrow-derived dendritic cells and t-cell activation by Candida albicans -- Phagocytosis and intracellular killing of Candida albicans by murine polymorphonuclear neutrophils -- Human oral keratinocytes: A model system to analyze host-pathogen interactions -- Simple assays for measuring innate interactions with fungi -- Binding and uptake of Candida albicans by human monocyte-derived dendritic cells -- Immune responses to Candida albicans in models of in vitro reconstituted human oral epithelium -- Analysis of host-cell responses by immunoblotting, ELISA, and real-time PCR -- In vitro model of invasive pulmonary aspergillosis in the human alveolus -- Biofilm formation studies in microtiter plate format -- Transcript profiling using ESTs from Paracoccidioides brasiliensis in models of infection -- Laser capture microdissection of Candida albicans from host tissue -- Isolation and amplification of fungal RNA for microarray analysis from host samples -- Cytokine measurement using cytometric bead arrays -- Transcript profiling of the murine immune response to invasive aspergillosis -- Caenorhabditis elegans: A nematode infection model for pathogenic fungi -- Drosophila melanogaster as a model organism for invasive aspergillosis -- Galleria mellonella as a model for fungal pathogenicity testing -- Embryonated chicken eggs as alternative infection model for pathogenic fungi -- Mouse intravenous challenge models and applications -- A nebulized intra-tracheal rat model of invasive pulmonary aspergillosis -- Invasive models of histoplasmosis -- Murine model of concurrent oral and vaginal Candida albicans colonisation -- A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections -- Modeling of fungal biofilms using a rat central vein catheter -- Orogastrointestinal model of mucosal and disseminated candidiasis -- A nonlethal murine cutaneous model of invasive aspergillosis.
  • Digital
    Smita Gopinath.
    Host-adapted pathogens depend on their host for transmission and dissemination to new hosts. Salmonella enterica includes a plethora of serovars that cause host-adapted diseases in both livestock animals and humans, an example of which is Salmonella enterica serovar Typhi, the causative agent of typhoid fever. Epidemiological and mathematical modeling data indicate that a specific subset of infected hosts are responsible for the majority of disease transmission. Human typhoid carriers are a classic example of this subset, characterized by persistently infected yet asymptomatic individuals who transmit disease via the fecal oral route. The work contained in this thesis attempts to answer how carriers differ from other hosts, in particular how the host immune response in carriers allows those individuals to remain asymptomatic despite the large numbers of Salmonella in the gastrointestinal tract. We use a mouse model of persistent Salmonella infection wherein a subset of the infected hosts (super-shedders) are able to transmit disease to naive cage mates. Having characterized the development of the host immune response during chronic Salmonella infection, we identify an immune state unique to super-shedder hosts. The super-shedder immune phenotype consists of an active innate immune response with high frequency of neutrophils and serum Interleukin-6 and a suppressed adaptive T cell response with dampened cytokine responsiveness. Administration of Granulocyte colony stimulating factor to moderate-shedders is sufficient to phenocopy the blunted T cell responses of the super-shedder immune state demonstrating that neutrophils control the suppression of the adaptive T cell response. The super-shedder immune state also serves a functional purpose, protecting the host against antibiotic-driven dysbiosis. The microbiota and host-pathogen interactions together induce a unique state of tolerance in Salmonella carriers, potentially contributing to the transmission of the pathogen in the general population.
  • Digital
    Andrew Hotson.
    The immune response to a pathogen is a complex interplay between host factors aimed to eradicate the pathogen, and microbe virulence proteins designed to subvert the host. To successfully combat a pathogen, the host must identify the insult and activate an immune response tailored to eliminate the specific microbe. This entails cell signaling at the level of innate immunity to detect the pathogen and mount an immediate non-specific response, while also communicating to bystander cells to shape the scope of the adaptive arm of immunity. The work herein investigates how the intracellular signaling network is activated and perturbed across cell types and hematopoietic tissues during bacterial infection. An introductory background on the current knowledge in the field of immune signaling is provided in chapter 1. Antigen presenting cells detect pathogenic motifs via pattern recognition receptors including toll-like receptors. This triggers an intracellular signaling cascade with specific transcriptional consequences, including the production of cytokines. In turn, these cytokines alert additional cell types to activate specific signal transducer and activator of transcription (STAT) transcription factor family members. Thus, detection of a microbe initiates rapid signaling across leukocytes to set the stage for the immune response. Chapter 2 focuses on cell signaling experiments in a murine model for the onset of sepsis. Mice were acutely challenged with avirulent E. coli and Listeria monocytogenes to study the host response without pathogenic manipulation of host signaling by bacterial virulence factors. Bacterial challenge causes macrophages and dendritic cells to become attenuated in their ability to respond to TLR agonists, a hallmark of endotoxin tolerance. Also, it induces global dampening of the STAT response to cytokines across all cell types; splenocytes from challenged mice poorly respond to cytokine stimulation. Cytokines secreted by antigen presenting cells act on bystander cells and induced negative feedback, including SOCS expression and receptor endocytosis that prevent further STAT activation. Thus, bacterial recognition causes host immune activation followed by subsequent suppression of signaling. The work in chapter 3 transitions to a model of chronic infection with pathogenic Salmonella typhimurium. In addition to examining the innate response, this model enables investigation of adaptive immunity by monitoring the activation of T cells, their cytokine response profile, and TH-biasing by the transcription factors they express and cytokines they produce. During chronic infection, B cells and effector T cells undergo expansion but not contraction over the first 30 days, demonstrating that the immune system establishes a new equilibrium. However, the degree of cell expansion, as well as the ability of these cells to respond to cytokine, is quite variable across mice. These mice also have varied levels of bacterial burden, and the shape of the immune response denotes disease severity. High bacterial load is associated with trademarks of innate immunity such as elevated neutrophil numbers, serum cytokine levels, and the dampened STAT signaling observed during bacterial challenge in chapter 2. In contrast, the mice that control infection are enriched for markers of adaptive T cell immunity: high numbers of TH1 effector T cells, T cell proliferation, ability to respond to cytokines, and fewer regulatory T cells. Therefore, a strong adaptive response is correlated with containing the infection, while an innate response is indicative of high bacterial levels. This thesis concludes in chapter 4, with a discussion of how the findings fit in the context of cell signaling in other disease states. Leukemia and lymphomas, diseases of uncontained cell growth, are characterized by hyperactive cell signaling. In contrast, an activated immune response, such as during auto-immunity or in cancer infiltrating T cells, is marked by repressed ability to respond to cytokines. As inhibited cytokine responses were also observed during bacterial challenge and during severe chronic infection, it appears that a commonality amongst disease that activate an immune response is negative feedback to dampen further signaling and restrict inflammation.
  • Digital
    edited by Steffen Rupp and Kai Sohn.
    Springer Protocols2008
  • Digital
    G. Singh Chhatwal, editor.
    Springer2013
    Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
  • Digital
    Anna Poukchanski.
    Toxoplasma gondii is an obligate intracellular parasite. It has extraordinary abilities to infect virtually any warm blooded animal, cross a number of biological barriers (intestine, placenta and blood-brain), and invade any nucleated cell tested thus far in vitro. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to invade the host cell. Emphasis is placed on biological barriers and molecular mechanism of invasion for the different forms of the parasite. Chapter 2 describes a study of how Toxoplasma crosses the human placenta. Chapter 3 provides an insight as to how Enteric Glial Cells contribute to oral Toxoplasma infection in vivo. Chapter 4 deals with the study of how Toxoplasma sporozoites invade host cells. All research topics shed light on details of how Toxoplasma crosses the anatomical barriers: from the tissue barriers of placenta to infection to the possible immune and barrier functions of Enteric Glial Cells to how Toxoplasma sporozoites invade host cells. Chapter 2 describes experiments demonstrating that Toxoplasma tachyzoites invade the human placenta. These experiments used the human placental explant system to determine where the tachyzoites first invade, how they travel down the anchoring villi, and whether there exist type differences in ability to invade this tissue. This study provided several insights: (i) Toxoplasma tachyzoites are unable to penetrate the syncytium, and invade only the exposed tissue (anchoring villi); (ii) There does not appear to be a significant difference in the ability of different strains to infect the tissue. Chapter 3 addresses the possible role of TGF-[beta] by Enteric Glial Cells (EGCs) in oral Toxoplasma infection. Mice expressing a Dominant Negative TGF-[beta] receptor in EGCs were orally infected with Toxoplasma tissue cysts. At the end of the time trials, mice were sacrificed and their intestines subjected to histological analysis. Experiments did not reveal a clear-cut contribution to the control of inflammation by this cell type to the progress of disease. Chapter 4 examines the function of two paralogues of AMA1 and RON2 that are present exclusively in Toxoplasma sporozoites. Dubbed sporoAMA1 and sporoRON2, respectively, that sporoRON2 and sporoAMA1 form an exclusive pairing, stabilized with unique structural features. Furthermore, pre-treating sporozoites with a C-terminal portion of sporoRON2 (but not generic RON2) inhibits sporozoite invasion. We see sporoRON2 in a different compartment from RON4, suggesting that sporoRON2 functions independently of known moving junction components. These data indicate that sporozoites' host cell invasion is dependent on a novel, stage-specific version of the AMA1-RON2 pairing.
  • Digital
    volume editor, Axel A. Brakhage, Peter F. Zipfel.
    Springer2008
  • Digital
    edited by Brian Henderson and Luigi Nibali.
    Wiley2016
    An introduction to the human tissue microbiome. The human microbiota / Michael Wilson -- An introduction to microbial dysbiosis / Mike Curtis -- The gut microbiota / Herve M Blottiere, Joel Dore -- The oral microbiota / William G Wade -- The skin microbiota / Patrick LJM Zeeuwen, Joost Schalkwijk -- Metagenomic analysis of the human microbiome / Luis G Bermudez-Humaran -- Microbiota-microbiota and microbiota-host interactions in health and disease. Systems biology of bacteria-host interactions / Almut Heinken, Dmitry A Ravcheev, Ines Thiele -- Bacterial biofilm formation and immune evasion mechanisms / Jessica Snowden -- Co-evolution of microbes and immunity and its consequences for modern day life / Markus B Geuking -- How viruses and bacteria have shaped the human genome / Frank Ryan -- The microbiota as an epigenetic control mechanism / Boris A Shenderov -- The emerging role of propionibacteria in human health and disease / Holger Bruggemann -- Dysbioses and bacterial diseases. The periodontal diseases / Luigi Nibali -- The polymicrobial synergy and dysbiosis model of periodontal disease pathogenesis / George Hajishengallis, Richard J Lamont -- New paradigm in the relationship between periodontal disease and systemic diseases / Kazuhisa Yamazaki -- The vaginal microbiota in health and disease / S Tariq Sadiq, Phillip Hay -- Dysbioses and chronic diseases. Reactive arthritis / John D Carter -- Rheumatoid arthritis / Jacqueline Detert -- Inflammatory bowel disease and the gut microbiota / Nik Ding, Ailsa Hart -- Ankylosing spondylitis, Klebsiella and the low-starch diet / Alan Ebringer, Taha Rashid, Clyde Wilson -- Microbiome of chronic plaque psoriasis / Lionel Fry -- Liver disease / Katharina Brandl, Bernd Schnabl -- The gut microbiota / Frida Fak -- The microbiota and susceptibility to asthma / Olawale Salami, Benjamin J Marsland -- Microbiome and cancer / Ralph Francescone, Debora B Vendramini-Costa -- Colorectal cancer and the microbiota / Iradj Sobhani, Severine Couffin -- The gut microbiota and the CNS / Aadil Bharwani, Paul Forsythe -- Genetic dysbiosis / Luigi Nibali -- Mirroring the future. Diet and dysbiosis / Mehrbod Estaki, Candice Quin, Deanna L Gibson -- Probiotics and prebiotics / Marie Jose Butel, Anne-Judith Waligora Dupriet -- The microbiota as target for therapeutic intervention in pediatric intestinal diseases / Andrea Lo Vecchio, Alfredo Guarino -- Microbial therapy for cystic fibrosis / Eugenia Bruzzese, Vittoria Buccigrossi, Giusy Ranucci, Alfredo Guarino.
  • Digital
    Juan J. Lafaille, Maria A. Curotto de Lafaille, editors.
    Springer2015
    Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
  • Digital
    edited by Dieter Kabelitz and Stefan H.E. Kaufmann.
    ScienceDirect2010
    1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • Digital
    Laura Santambrogio, editor.
    Springer2013
    Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
  • Digital
    Anton G. Kutikhin, Arseniy E. Yuzhalin, Elena B. Brusina.
    Springer2013
    The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
  • Digital
    edited by Steffen Backert, editor.
    Springer2016
    This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future.
  • Digital
    Richard W. Compans, Michael B.A. Oldstone, editors.
    Springer2014
    This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
  • Digital
    Michael B.A. Oldstone, Richard W. Compans, editors.
    Springer2015
    Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
  • Digital
    Gerri S. Hall, editor.
    Springer2012
    Antifungal agents -- Antifungal susceptibility testing: Clinical Laboratory and Standards Institute (CLSI) methods -- Antifungal susceptibility testing methods: non-CLSI methods for yeast and moulds -- Susceptibility testing of dermatophytes -- Usual susceptibility patterns of common yeasts -- Usual susceptibility patterns of common moulds and systemic fungi -- Usual susceptibility patterns for systemic dimorphic fungi -- Utility of antifungal susceptibility testing and clinical correlations.
  • Digital
    K. Sasaki, O. Suzuki, N. Takahashi, editors ; P. Stashenko, ... [et al.], associate editors.
    Springer2012
  • Digital
    Simon Fillatreau, Anne O'Gara, editors.
    Springer2014
    " This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
  • Digital
    editors, Eduardo J. Schiffrin, Philippe Marteau, Dominique Brassart.
    CRCnetBASE2014
    1. Commensal intestinal microbiota and mucosal immune system development and function / Katarina Radulovic and Jan Hendrik Niess -- 2. Presentation of microbial signals via maternal cells : an evolutionary advantage of mammals / Pablo F. Perez, Anne Donnet-Hughes and Eduardo J. Schiffrin -- 3. Interactions of the intestinal microbiota with mucosal epithelial cells / Cherbuy Claire, Tomas Julie, Thomas Muriel and Langella Philippe -- 4. Pathogen-host cell interactions at the intestinal level : 88 lessons from cultured human fully-differentiated colon cancer Caco-2 and T84 epithelial cell lines / Vanessa Liv̌in-Le Moal and Alain L. Servin -- 5. Manipulation of the host-cell pathways by bacterial enteropathogens / Brice Sperandio and Philippe J. Sansonetti -- 6. The role of probiotics in prevention and treatment of GI infections / Christina M. Surawicz and Christopher Damman -- 7. The microbiota in inflammatory bowel disease / Philippe Marteau, Marion Leclerc, Patricia Lepage, Philippe Seksik, Harry Sokol and Joel Dor ̌-- 8. Opportunistic pathogens in inflammatory bowel disease, and the relation with specific gene susceptibilities / Marianne Fraher and Fergus Shanahan -- 9. Opportunistic pathogens in inflammatory bowel disease, the case of adherent-invasive e. coli / Arlette Darfeuille-Michaud -- 10. Correction of microbiota disturbances or antagonism against specific pathogens in IBD / Paul K. Flanagan and Jonathan M. Rhodes -- 11. Probiotics in inflammatory bowel disease : modulation of the pathological immune or inflammatory activation. Their potential benefits in the different phases of the disease / Siew C. Ng and Ailsa L. Hart -- 12. Mechanisms, prevention and management of diarrhoea in enteral nutrition / Kevin Whelan and Stp̌hane M. Schneider -- 13. Influence of the intestinal microbiota on the critically ill patient / Robert G. Martindale, Stephen A. McClave, Malissa Warren and Svetang Desai -- 14. Gut microbiota in obesity and Type-2 diabetes : links with diet and weight loss intervention / Judith Aron-Wisnewsky and Karine Clm̌ent.
  • Digital
    Bryan R. Cullen, editor.
    Springer2013
    The APOBEC3 Family of Retroelement Restriction Factors / Eric W. Refsland, Reuben S. Harris -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family / Adam J. Fletcher, Greg J. Towers -- The Antiviral Activities of Tetherin / Stuart J. D. Neil -- Restriction of Retroviral Infection of Macrophages / Mark Sharkey -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors / Welkin E. Johnson -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants / György Szittya, József Burgyán -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates / Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses / Eva Gottwein -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response / Karyn McFadden, Micah A. Luftig.
  • Digital
    B. Rowe Byers, editor.
    Springer2013
    Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
  • Digital/Print
    Adelberg, Edward A.; Brooks, George F.; Jawetz, Ernest; Melnick, Joseph L.
    Digital : AccessMedicine27th ed., 2016
    Digital : AccessMedicine26th ed., 2010
  • Digital
    Vijai Kumar Gupta, Maria G. Tuohy, editors ; Manimaran Ayyachamy, Kevin M. Turner, Anthonia O'Donovan, associate editors.
    Springer2013
    Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals.
  • Digital
    Berenice C. Langdon, Aodhán S. Breathnach.
    Oxford Medicine Online2016
    'Learning Microbiology through Clinical Consultation' is a highly accessible text which describes the fundamentals of microbiology within the practice setting in an informative way. It is an ideal resource for medical students and newly qualified doctors, as well as anyone wishing to study medicine or preparing for medical school interviews.
  • Digital
    Paul Hoffman, Herman Friedman, Mauro Bendinelli.
    Springer2008
  • Digital
    Ben Adler, Editor.
    Springer2015
    This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world?s most widespread zoonosis. Topics include aspects of human and animal leptospirosis as well as detailed analyses of our current knowledge of leptospiral structure and physiology, epidemiology, pathogenesis, genomics, immunity and vaccines. Updates are presented on leptospiral systematics, identification and diagnostics, as well as practical information on culture of Leptospira. Contact information is also provided for Leptospira reference centers. All chapters were written by experts in the field, providing an invaluable reference source for scientists, veterinarians, clinicians and all others with an interest in leptospirosis.
  • Digital
    edited by Kieran Jordan, Edward M. Fox, Martin Wagner.
    Springer Protocols2014
    Listeria monocytogenes is still a major threat to public health. A new book in the Methods in Molecular Biology series, Listeria monocytogenes: Methods and Protocols addresses its titular pathogen with protocols and methodologies used in research to gain a better understanding of Listeria at a molecular level. The topics covered include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation, and, finally, methods for control of the organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Listeria monocytogenes: Methods and Protocols aims to contribute to the harmonization of the methods used in the field and will therefore benefit all those interested in Listeria research.
  • Digital
    Arch G. Mainous III, Claire Pomeroy, editors.
    Springer2010
  • Digital
    editors in chief, James H. Jorgensen, Emeritus, Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, Michael A. Pfaller, T2 Biosystems, Lexington, Massachusetts, and Professor Emeritus, University of Iowa College of Medicine, Iowa City, Iowa ; volume editors, Karen C. Carroll, Department of Pathology, Division of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland [and 4 others].
    ASM2015
    V. 1: Introduction to the 11th Edition of the Manual of Clinical Microbiology -- Microscopy -- Laboratory Detection of Bacteremia and Fungemia -- Systems for Identification of Bacteria and Fungi -- Automation and Design of the Clinical Microbiology Laboratory -- Molecular Microbiology -- Immunoassays for Diagnosis of Infectious Diseases -- Prevention of Health Care-Associated Infections -- Investigation of Disease Outbreaks -- Molecular Epidemiology -- Procedures for the Storage of Microorganisms -- Prevention of Laboratory-Acquired Infections -- Decontamination, Disinfection, and Sterilization -- Biothreat Agents -- The Human Microbiome -- Microbial Genomics and Pathogen Discovery -- Taxonomy and Classification of Bacteria -- Specimen Collection, Transport, and Processing: Bacteriology -- Reagents, Stains, and Media: Bacteriology -- General Approaches to Identification of Aerobic Gram-Positive Cocci -- Staphylococcus, Micrococcus, and Other Catalase-Positive Cocci -- Streptococcus -- Enterococcus -- Aerococcus, Abiotrophia, and Other Aerobic Catalase-Negative, Gram-Positive Cocci -- General Approaches to the Identification of Aerobic Gram-Positive Rods -- Bacillus and Other Aerobic Endospore-Forming Bacteria -- Listeria and Erysipelothrix -- Coryneform Gram-Positive Rods -- Nocardia, Rhodococcus, Gordonia, Actinomadura, Streptomyces, and Other Aerobic Actinomycetes -- Mycobacterium: General Characteristics, Laboratory Detection, and Staining Procedures -- Mycobacterium: Laboratory Characteristics of Slowly Growing Mycobacteria -- Mycobacterium: Clinical and Laboratory Characteristics of Rapidly Growing Mycobacteria -- Approaches to the Identification of Aerobic Gram-Negative Bacteria -- Neisseria -- Aggregatibacter, Capnocytophaga, Eikenella, Kingella, Pasteurella, and Other Fastidious or Rarely Encountered Gram-Negative Rods -- Haemophilus -- Escherichia, Shigella, and Salmonella -- Klebsiella, Enterobacter, Citrobacter, Cronobacter, Serratia, Plesiomonas, and Other Enterobacteriaceae -- Yersinia -- Aeromonas -- Vibrio and Related Organisms -- Pseudomonas -- Burkholderia, Stenotrophomonas, Ralstonia, Cupriavidus, Pandoraea, Brevundimonas, Comamonas, Delftia, and Acidovorax -- Acinetobacter, Chryseobacterium, Moraxella, and Other Nonfermentative Gram-Negative Rods -- Bordetella and Related Genera -- Francisella -- Brucella -- Bartonella -- Legionella -- Approaches to Identification of Anaerobic Bacteria -- Peptostreptococcus, Finegoldia, Anaerococcus, Peptoniphilus, Veillonella, and Other Anaerobic Cocci -- Propionibacterium, Lactobacillus, Actinomyces, and Other Non-Spore-Forming Anaerobic Gram-Positive Rods -- Clostridium -- Bacteroides, Porphyromonas, Prevotella, Fusobacterium, and Other Anaerobic Gram-Negative Rods -- Algorithms for Identification of Curved and Spiral-Shaped Gram-Negative Rods -- Campylobacter and Arcobacter -- Helicobacter -- Leptospira -- Borrelia -- Treponema and Brachyspira, Human Host-Associated Spirochetes -- General Approaches to Identification of Mycoplasma, Ureaplasma, and Obligate Intracellular Bacteria -- Mycoplasma and Ureaplasma -- Chlamydiaceae -- Rickettsia and Orientia -- Ehrlichia, Anaplasma, and Related Intracellular Bacteria -- Coxiella -- Tropheryma whipplei -- Antibacterial Agents -- Mechanisms of Resistance to Antibacterial Agents -- Susceptibility Test Methods: General Considerations -- Susceptibility Test Methods: Dilution and Disk Diffusion Methods -- Antimicrobial Susceptibility Testing Systems -- Special Phenotypic Methods for Detecting Antibacterial Resistance -- Susceptibility Test Methods: Fastidious Bacteria -- Susceptibility Test Methods: Anaerobic Bacteria -- Susceptibility Test Methods: Mycobacteria, Nocardia, and Other Actinomycetes -- Molecular Detection of Antibacterial Drug Resistance. V. 2: Taxonomy and Classification of Viruses -- Specimen Collection, Transport, and Processing: Virology -- Reagents, Stains, Media, and Cell Cultures: Virology -- Algorithms for Detection and Identification of Viruses -- Human Immunodeficiency Viruses -- Human T-Cell Lymphotropic Viruses -- Influenza Viruses -- Parainfluenza and Mumps Viruses -- Respiratory Syncytial Virus and Human Metapneumovirus -- Measles and Rubella Viruses -- Enteroviruses and Parechoviruses -- Rhinoviruses -- Coronaviruses -- Hepatitis A and E Viruses -- Hepatitis C Virus -- Gastroenteritis Viruses -- Rabies Virus -- Arboviruses -- Hantaviruses -- Arenaviruses and Filoviruses -- Herpes Simplex Viruses and Herpes B Virus -- Varicella-Zoster Virus -- Human Cytomegalovirus -- Epstein-Barr Virus -- Human Herpesviruses -- Adenoviruses -- Human Papillomaviruses -- Human Polyomaviruses -- Parvovirus B19 and Bocaviruses -- Poxviruses -- Hepatitis B and D Viruses -- Transmissible Spongiform Encephalopathies -- Antiviral Agents -- Mechanisms of Resistance to Antiviral Agents -- Susceptibility Test Methods: Viruses -- Taxonomy and Classification of Fungi -- Specimen Collection, Transport, and Processing: Mycology -- Reagents, Stains, and Media: Mycology -- General Approaches for Direct Detection and Identification of Fungi -- Candida, Cryptococcus, and Other Yeasts of Medical Importance -- Pneumocystis -- Aspergillus and Penicillium -- Fusarium and Other Opportunistic Hyaline Fungi -- Agents of Systemic and Subcutaneous Mucormycosis and Entomophthoromycosis -- Histoplasma, Blastomyces, Coccidioides, and Other Dimorphic Fungi Causing Systemic Mycoses -- Trichophyton, Microsporum, Epidermophyton, and Agents of Superficial Mycoses -- Curvularia, Exophiala, Scedosporium, Sporothrix, and Other Melanized Fungi -- Fungi Causing Eumycotic Mycetoma -- Mycotoxins -- Lacazia, Lagenidium, Pythium, and Rhinosporidium -- Microsporidia -- Antifungal Agents -- Mechanisms of Resistance to Antifungal Agents -- Susceptibility Test Methods: Yeasts and Filamentous Fungi -- Taxonomy and Classification of Human Parasitic Protozoa and Helminths -- Specimen Collection, Transport, and Processing: Parasitology -- Reagents, Stains, and Media: Parasitology -- General Approaches for Detection and Identification of Parasites -- Plasmodium and Babesia -- Leishmania and Trypanosoma -- Toxoplasma -- Pathogenic and Opportunistic Free-Living Amebae -- Intestinal and Urogenital Amebae, Flagellates, and Ciliates -- Cystoisospora, Cyclospora, and Sarcocystis -- Cryptosporidium -- Nematodes -- Filarial Nematodes -- Cestodes -- Trematodes -- Less Common Helminths -- Arthropods of Medical Importance -- Antiparasitic Agents -- Mechanisms of Resistance to Antiparasitic Agents -- Susceptibility Test Methods: Parasites.
  • Digital
    Allan L. Truant, editor-in-chief.
    Wiley2016
    Role of the U.S Food and Drug Administration (FDA) in the regulation of clinical microbiology devices / Kathleen B. Whitaker, Sally A. Hojvat, and Estelle Russek-Cohen -- Commercial blood culture systems and methods / Micheal L. Wilson, Melvin P. Weinstein, and L. Barth Reller -- Rapid devices and instruments for the identification of aerobic bacteria / Laura J. Chandler, P. Rocco LaSala, and Susan Whittier -- Rapid devices and instruments for the identification of anaerobic bacteria / Christopher L. Emery, Maria D. Appleman, Jean A. Siders, Thomas E. Davis (and Stephen D. Allen, deceased) -- Rapid antigen devices and instruments for the detection and identification of viruses / Wallace H. Greene, Marilyn A. Menegus, and Allan L. Truant -- Molecular tests for the identification of viruses / Scott Duong and Christine C. Ginocchio -- Viral hepatitis / Emily Cartwright and Yun F. (Wayne) Wang -- Human papillomaviruses / N. Esther Babdy -- Human immunodeficiency virus / Richard L. Hodinka -- Chlamydia / Claudiu I. Bandea, Robert C. Jerris, and Carolyn M. Black -- Mycoplasma / Ken B. Waites and Cecile Bbar -- Commercial methods for identification and susceptibility testing of fungi / Stephen A. Moser and Jason Wicker -- Mycobacteria / Xiang Yang Han -- Diagnostic medical parasitology / Lynne S. Garcia and Gary W. Procop -- Molecular microbiology / Raghava Potula and Yi-Wei Tang -- Automated immunoassay analyzers / Richard L. Hodinka and Matthew J. Binnicker -- Molecular typing instruments and methods / Ruth Ann Luna -- Commercial methods in clinical veterinary microbiology / Thomas J. Inzana, Xiang-Jin Meng, Tanja Opriessing, and Lora Ballweber -- Microbiology laborry information systems / Raymond D. Aller and Vincent Salazar -- Emerging infectious diseases / Brett Laurence, Julie Collins, Carolyn Fernandes, Rafik Samuel, and Byungse Suh -- Automated and manual systems for antimicrobial susceptibility testing of bacteria / Alan T. Evangelista and James A. Karlowsky -- Bioterrorism / James W. Snyder and Michael A. Pentella -- Clinical microbiology : looking ahead / Natalie N. Whitfield, Raquel M. Martinez, and Donna M. Wolk.
  • Print
    Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by David Greenwood [and others].
    ClinicalKey2012
    Microbiology and medicine -- Morphology and nature of micro-organisms -- Classification, identification and typing of micro-organisms -- Bacterial growth, physiology and death -- Antimicrobial agents -- Bacterial genetics -- Virus-cell interactions -- Immunological principles: Antigens and antigen recognition -- Innate and acquired immunity -- Immunity in viral infections -- Parasitic infections: Pathogenesis and immunity -- Immunity in bacterial infections -- Bacterial pathogenicity -- The natural history of infection -- Staphylococcus: Skin infections; osteomyelitis; bloodstream infection; food poisoning; foreign body infections; MRSA -- Streptococcus and enterococcus: Pharyngitis; scarlet fever; skin and soft tissue infections; streptococcal toxic shock syndrome; pneumonia; meningitis; urinary tract infections; rheumatic fever; post-streptococcal glomerulonephritis -- Coryneform bacteria, listeria and erysipelothrix: Diphtheria; listeriosis; erysipeloid -- Mycobacterium: Tuberculosis; leprosy -- Environmental mycobacteria: Opportunist disease -- Actinomyces, nocardia and tropheryma: Actinomycosis; nocardiasis; Whipple's disease -- Bacillus: Anthrax; food poisoning -- Clostridium: Gas gangrene; tetanus; food poisoning; pseudomembranous colitis -- Neisseria and moraxella: Meningitis; septicaemia; gonorrhoea; respiratory infections -- Salmonella: Food poisoning; enteric fever -- Shigella: Bacillary dysentery -- Escherichia: Urinary tract infection; travellers' diarrhoea; haemorrhagic colitis; haemolytic uraemic syndrome -- Klebsiella, enterobacter, proteus and other enterobacteria: Pneumonia; urinary tract infection; opportunist infection -- Pseudomonads and non-fermenters: Opportunist infection; cystic fibrosis; melioidosis -- Campylobacter and helicobacter: Enteritis; polyneuropathy; gastritis; peptic ulcer disease; gastric cancer -- Vibrio, mobiluncus, gardnerella and spirillum: Cholera; vaginosis; rat bite fever -- Haemophilus: Respiratory infections; meningitis; chancroid -- Bordetella: Whooping cough -- Legionella: Legionnaires' disease; Pontiac fever -- Brucella, bartonella and streptobacillus: Brucellosis; Oroya fever; trench fever; cat scratch disease; bacillary angiomatosis; rat bite fever -- Yersinia, pasteurella and francisella: Plague; pseudotuberculosis; mesenteric adenitis; pasteurellosis; tularaemia -- Non-sporing anaerobes: Wound infection; periodontal disease; abscess; normal flora -- Treponema and borrelia: Syphilis; yaws; relapsing fever; Lyme disease -- Leptospira: Leptospirosis; Weil's disease -- Chlamydia: Genital and ocular infections; infertility; atypical pneumonia -- Rickettsia, orientia, ehrlichia, anaplasma and coxiella: Typhus; spotted fevers; scrub typhus; ehrlichioses; Q fever -- Mycoplasmas: Respiratory and genital tract infections -- Adenoviruses: Respiratory disease; conjunctivitis; gut infections -- Herpesviruses: Herpes simplex; varicella and zoster; infectious mononucleosis; B cell lymphomas; cytomegalovirus disease; exanthem subitum; Kaposi's sarcoma; herpes B -- Poxviruses: Smallpox; molluscum contagiosum; parapoxvirus infections -- Papillomaviruses and polyomaviruses: Warts: warts and cancers; polyomavirus associated nephropathy; progressive multifocal leuco-encephalopathy -- Hepadnaviruses: Hepatitis B virus infection; hepatitis delta virus infection -- Parvoviruses: B19 infection; erythema infectiosum -- Picornaviruses: Meningitis; paralysis; rashes; intercostal myositis; myocarditis; infectious hepatitis; common cold -- Orthomyxoviruses: Influenza -- Paramyxoviruses: Respiratory infections; mumps; measles; Hendra/Nipah disease -- Arboviruses: alphaviruses, flaviviruses and bunyaviruses: Encephalitis; yellow fever; dengue; haemorrhagic fever; miscellaneous tropical fevers; undifferentiated fever -- Hepaciviruses and hepeviruses: Hepatitis C and E viruses; non-A, non-B hepatitis -- Arenaviruses and filoviruses: Viral haemorrhagic fevers -- Reoviruses: Gastroenteritis -- Retroviruses: Acquired immune deficiency syndrome; HTLV-1 -- Caliciviruses and astroviruses: Diarrhoeal disease -- Coronaviruses -- Rhabdoviruses -- Togaviruses: Rubella -- Prion diseases (transmissible spongiform encephalopathies): Creutzfeldt-Jakob disease; Gerstmann-Sträussler-Scheinker syndrome; fatal familial insomnia; iatrogenic Creutzfeldt-Jakob disease; kuru; variant Creutzfeldt-Jakob disease; bovine spongiform encephalopathy; scrapie-- Fungi: Superficial, subcutaneous and systemic mycoses -- Protozoa: Malaria; toxoplasmosis; cryptosporidiosis; amoebiasis; trypanosomiasis; leishmaniasis; giardiasis; trichomoniasis -- Helminths: Intestinal worm infections; filariasis; schistosomiasis; hydatid disease -- Arthropods: Arthropod-borne diseases; ectoparasitic infections; allergy -- Infective syndromes -- Diagnostic procedures -- Strategy of antimicrobial chemotherapy -- Epidemiology and control of community infections -- Hospital infection -- Immunization.
  • Digital
    Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller.
    ClinicalKey2016
    Introduction to medical microbiology -- Human microbiome in health and disease -- Sterilization, disinfection, and antisepsis -- Microscopy and in vitro culture -- Molecular diagnosis -- Serologic diagnosis -- Elements of host protective responses -- Innate host responses -- Antigen-specific immune responses -- Immune responses to infectious agents -- Antimicrobial vaccines -- Bacterial classification, structure, and replication -- Bacterial metabolism and genetics -- Mechanisms of bacterial pathogenesis -- Role of bacteria in disease -- Laboratory diagnosis of bacterial diseases -- Antibacterial agents -- Staphylococcus and related gram-positive cocci -- Streptococcus and Enterococcus -- Bacillus -- Listeria and related gram-positive bacteria -- Mycobacterium and related acid-fast bacteria -- Neisseria and related genera -- Haemophilus and related bacteria -- Enterobacteriaceae -- Vibrio and related bacteria -- Pseudomonas and related bacteria -- Campylobacter and helicobacter -- Miscellaneous gram-negative rods -- Clostridium -- Non-spore-forming anaerobic bacteria -- Treponema, Borrelia, and Leptospira -- Mycoplasma and Ureaplasma -- Rickettsia, Ehrlichia, and related bacteria -- Chlamydia and Chlamydophila -- Viral classification, structure, and replication -- Mechanisms of viral pathogenesis -- Role of viruses in disease -- Laboratory diagnosis of viral diseases -- Antiviral agents and infection control -- Papillomaviruses and polyomaviruses -- Adenoviruses -- Human herpesviruses -- Poxviruses -- Parvoviruses -- Picornaviruses -- Coronaviruses and noroviruses -- Paramyxoviruses -- Orthomyxoviruses -- Rhabdoviruses, Filoviruses, and Bornaviruses -- Reoviruses -- Togaviruses and flaviviruses -- Bunyaviridae and Arenaviridae -- Retroviruses -- Hepatitis viruses -- Prion diseases -- Fungal classification, structure, and replication -- Pathogenesis of fungal disease -- Role of fungi in disease -- Laboratory diagnosis of fungal disease -- Antifungal agents -- Superficial and cutaneous mycoses -- Subcutaneous mycoses -- Systemic mycoses caused by dimorphic fungi -- Opportunistic mycoses -- Fungal and fungal-like infections of unusual or uncertain etiology -- Mycotoxins and mycotoxicoses -- Parasitic classification, structure, and replication -- Pathogenesis of parasitic diseases -- Role of parasites in disease -- Laboratory diagnosis of parasitic disease -- Antiparasitic agents -- Intestinal and urogenital protozoa -- Blood and tissue protozoa -- Nematodes -- Trematodes -- Cestodes -- Arthropods.
  • Print
    David W. Hecht, Diane M. Citron, Joanne Dzink-Fox, William W. Gregory, Nilda V. Jacobs, Stephen G. Jenkins, Jon E. Rosenblatt, Audrey N. Schuetz, Hannah Wexler.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Prakash S. Bisen, Mousumi Debnath, Godavarthi B.K.S. Prasad.
    Wiley2012
  • Digital
    G.N. Cohen.
    Springer2011
    Bacterial growth -- The outer membrane of gram-negative bacteria and the cytoplasmic membrane -- Peptidoglycan synthesis and cell division -- Cellular permeability -- Allosteric enzymes -- Glycolysis, gluconeogenesis and glycogen synthesis -- The pentose phosphate and Entner-Doudoroff pathways -- The tricarboxylic acid cycle and the glyoxylate bypass -- ATP-generating processes : respiration and fermentation -- Biosynthesis of lipids -- Iron-sulfur proteins -- The archaea -- Methanogens and methylotrophs -- Enzyme induction in catabolic systems -- Transcription : RNA polymerase -- Negative regulation -- Enzyme repression in anabolic pathways -- Positive regulation -- The ribosomes -- The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases -- Attenuation -- Riboswitches -- The biological fixation of nitrogen -- How biosynthetic pathways have been established -- The aspartic acid family of amino acids : biosynthesis -- Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae -- Other patterns of regulation of the synthesis of amino acids of the aspartate family -- Biosynthesis of the amino acids of the glutamic acid family and its regulation -- Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid -- Selenocysteine and selenoproteins -- Biosynthesis of aromatic amino acids and its regulation -- The biosynthesis of histidine and its regulation -- The biosynthesis of nucleotides -- The biosynthesis of deoxyribonucleotides -- Biosynthesis of some water-soluble vitamins and of their coenzyme forms -- Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones -- Biosynthesis of the tetrapyrrole ring system -- Biosynthesis of cobalamins including vitamin B12 -- Interactions between proteins and DNA -- Evolution of biosynthetic pathways.
  • Digital
    edited by Gianfranco Donelli.
    Springer Protocols2014
    Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms / Claus Sternberg, Thomas Bjarnsholt, and Mark Shirtliff -- Aqueous two-phase system technology for patterning bacterial communities and biofilms / Mohammed Dwidar, Shuichi Takayama, and Robert J. Mitchell -- Quorum sensing in gram-positive bacteria : assay protocols for Staphylococcal agr and Enterococcal fsr systems / Akane Shojima and Jiro Nakayama -- Advanced techniques for in situ analysis of the biofilm matrix (structure, composition, dynamics) by means of laser scanning microscopy / Thomas R. Neu and John R. Lawrence -- Multiplex fluorescence in situ hybridization (M-FISH) and confocal laser scanning microscopy (CLSM) to analyze multispecies oral biofilms / Lamprini Karygianni, Elmar Hellwig, and Ali Al-Ahmad -- Field emission scanning electron microscopy of biofilm-growing bacteria Involved in nosocomial infections / Claudia Vuotto and Gianfranco Donelli -- Experimental approaches to investigating the vaginal biofilm microbiome / Marc M. Baum, Manjula Gunawardana, and Paul Webster -- Imaging bacteria and biofilms on hardware and periprosthetic tissue in orthopedic infections / Laura Nistico, Luanne Hall-Stoodley, and Paul Stoodley -- Animal models to evaluate bacterial biofilm development / Kim Thomsen, Hannah Trøstrup, and Claus Moser -- Animal models to investigate fungal biofilm formation / Jyotsna Chandra, Eric Pearlman, and Mahmoud A. Ghannoum -- Nonmammalian model systems to investigate fungal biofilms / Marios Arvanitis ... [et al.] -- Microbiological methods for target-oriented screening of biofilm inhibitors / Livia Leoni and Paolo Landini -- In vitro screening of antifungal compounds able to counteract biofilm development / Marion Girardot and Christine Imbert -- Biofilm matrix-degrading enzymes / Jeffrey B. Kaplan -- Efficacy evaluation of antimicrobial drug-releasing polymer matrices / Iolanda Francolini, Antonella Piozzi, and Gianfranco Donelli -- Antibiotic polymeric nanoparticles for biofilm-associated infection therapy / Wean Sin Cheow and Kunn Hadinoto -- Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo / Wang Hengzhuang, Niels Høiby, and Oana Ciofu -- Contribution of confocal laser scanning microscopy in deciphering biofilm tridimensional structure and reactivity / Arnaud Bridier and Romain Briandet -- Chip calorimetry for evaluation of biofilm treatment with biocides, antibiotics, and biological agents / Frida Mariana Morais, Friederike Buchholz, and Thomas Maskow -- Bacteriophage attack as an anti-biofilm strategy / Sanna Sillankorva and Joana Azeredo -- Photodynamic therapy as a novel antimicrobial strategy against biofilm-based nosocomial infections : study protocols / Francesco Giuliani -- Capturing air-water interface biofilms for microscopy and molecular analysis / Margaret C. Henk -- Biofilm-growing bacteria involved in the corrosion of concrete wastewater pipes : protocols for comparative metagenomic analyses/ Vicente Gomez-Alvarez -- Culture-independent methods to study subaerial biofilm growing on biodeteriorated surfaces of stone cultural heritage and frescoes / Francesca Cappitelli, Federica Villa, and Andrea Polo -- Biofilms of thermophilic bacilli isolated from dairy processing plants and efficacy of sanitizers / Sara A. Burgess, Denise Lindsay, and Steve H. Flint.
  • Digital
    edited by José-Luis Barredo.
    Springer Protocols2012
    Pathways of carotenoid biosynthesis in bacteria and microalgae / J. Paniagua-Michel, Jorge Olmos-Soto, and Manuel Acosta Ruiz -- Selection and taxonomic identification of carotenoid-producing marine actinomycetes / Francisco Romero -- Isolation, characterization, and diversity of novel radiotolerant carotenoid-producing bacteria / Dalal Asker [and others] -- Novel radio-tolerant astaxanthin-producing bacterium reveals a new astaxanthin derivative : astaxanthin dirhamnoside / Dalal Asker [and others] -- Novel zeaxanthin-producing bacteria isolated from a radioactive hot spring water / Dalal Asker [and others] -- Novel approach in the biosynthesis of functional carotenoids in Escherichia coli / Hisashi Harada and Norihiko Misawa -- Engineering Escherichia coli for canthaxanthin and ataxanthin biosynthesis / Qiong Cheng and Luan Tao -- Analysis of canthaxanthin production by Gordonia jacobaea / Patricia Veiga-Crespo [and others] -- Isolation and light-stimulated expression of canthaxanthin and spirilloxanthin biosynthesis genes from the photosynthetic bacterium Bradyrhizobium sp. Strain ORS278 / Eric Giraud and Andre Vermeglio -- Construction of carotenoid biosynthetic pathways through chromosomal integration in methane-utilizing bacterium Methylomonas sp. strain 16a / Rick W. Ye and Kristen Kelly -- Genetic modification in Bacillus subtilis for production of C30 carotenoids / Isamu Maeda -- Carotenoids' production from halophilic bacteria / Maria de Lourdes Moreno [and others] -- Construction and utilization of carotenoid reporter systems : identification of chromosomal integration sites that support suitable expression of biosynthetic genes and pathways / Pamela L. Sharpe and Deana J. DiCosimo -- Directed evolution of carotenoid synthases for the production of unnatural carotenoids / Maiko Furubayashi and Daisuke Umeno -- High-Throughput Screen for the Identi fi cation of improved catalytic activity: b-carotene hydroxylase / Mark A. Scaife [and others] -- DNA fingerprinting intron-sizing method to accomplish a specific, rapid, and sensitive identification of carotenogenic Dunaliella species / Jorge Olmos-Soto [and others] -- Ketocarotenoid biosynthesis in transgenic microalgae expressing a foreign beta-C-4-carotene oxygenase gene / Marta Vila [and others] -- Characterization of carotenogenesis genes in the cyanobacterium Anabaena sp. PCC 7120 / Hajime Masukawa, Mari Mochimaru, and Shinichi Takaichi -- Obtaining lutein-rich extract from microalgal biomass at preparative scale / Jose M. Fernandez-Sevilla, F. Gabriel Acien Fernandez, and Emilio Molina Grima -- NMR-based isotopologue profiling of microbial carotenoids / Eva Eylert, Adelbert Bacher, and Wolfgang Eisenreich -- Analysis of diapocarotenoids found in pigmented Bacillus species / Laura Perez-Fons and Paul D. Fraser.
  • Digital
    edited by José-Luis Barredo.
    Springer Protocols2012
  • Digital
    editor, Vladimir Krcméry.
    Future Med2013
    Antibiotic resistance : postantibiotic era is here / Vladimir Krcmery -- Current challenges in treating methicillin-resistant Staphylococcus aureus : what are the options? / Noha E.I. Sakka & Ian M . Gould -- Antimicrobial-resistant Streptococcus pneumoniae : trends and management / Michael R. Jacobs -- Emergence and management of drug-resistant enterococcal infections / William R. Miller, Barbara E. Murray & Cesar A. Arias -- Enterobacteriaceae that produce newer b-lactamases / Johann D.D. Pitout -- Extensively drug-resistant tuberculosis : new strains, new challenges / Megan Coffee -- Clinical significance of extended-spectrum b-lactamases / Jesés Rodréguez-Baño, Belén Gutiérrez, Lorena Lépez-Cerero & Alvaro Pascual -- Plasmid-mediated quinolone resistance / José Manuel Rodréguez-Marténez, Maréa Eliecer Cano, Jorge Calvo, Álvaro Pascual & Luis Marténez-Marténez -- Antibiotic resistance in the absence of antimicrobial use / Lucia Pallecchi, Alessandro Bartoloni, Eduardo Gotuzzo & Gian Maria Rossolini -- Resistance in bacteria of the food chain : epidemiology and control strategies / Lina Maria Cavaco & Frank Møller Aarestrup -- Measures to prevent antimicrobial resistance / Vhairi M. Bateman & Ian M. Gould -- Where does novel antibiotics R&D stand among other pharmaceutical products? / Glenn S. Tillotson -- Resistance to antiretroviral drugs / Manuela Colafigli, Simona Di Giambenedetto & Roberto Cauda -- Index.
  • Digital
    Miling Yan.
    The establishment and wide acceptance of an abundant and diverse human-associated microbial community has been one of the most important shifts in the field of microbiology in the past decade. From a bacterial perspective, the body is a vast landscape whose shifting geography and fluctuating environmental conditions provide a range of distinct residential possibilities. Some habitats, such as the intestinal tract and the oral cavity, have been characterized more extensively than others; within these environs, an understanding of the interplay between microbial ecology and health and disease has begun to emerge. The nasal cavity, a crucial component of both the respiratory system and innate immune system, has yet to benefit from an exploration of similar depth. Recent examination of the nasal microbial habitat has almost exclusively focused on the anterior nares without examining deeper sites within the cavity which are actively involved in nasal mucociliary clearance and exposed to the efflux of various sinuses. The aim of this work was to explore this biogeography by characterizing the microbial communities in a range of spatial sites along the nasal passageway. Additionally, the nasal cavity has long been a source of pathogens, most notably Staphylococcus aureus. Carriage of S. aureus has been demonstrated to be a significant risk factor for acquisition of antibiotic resistant strains of S. aureus and hospital-acquired infections. The second aim of this project was to understand whether underlying community features may be present that were characteristic of S. aureus carriage. 13 healthy subjects (6 persistent and 7 non-persistent carriers) were sampled weekly at 3 different sites (anterior nares, middle meatus, and sphenoethmoidal recess) within the nasal cavity over a 4-week period. The data shows that biogeographical differences were based less upon spatial factors and more on epithelium type. The data also showed that the S. aureus carriage type of the individual contributed the greatest amount of non-S. aureus variation within the communities. Finally, a carriage-classifying model was generated from the data and examined for important predictive features, revealing a potential intra-genus, interspecific competitive interaction in Corynebacterium with implications on S. aureus carriage. These results highlight the complexity present in human microbial communities even within highly spatially constrained microenvironments.
  • Digital
    Mark Lyte, Primrose P.E. Freestone, editors.
    Springer2010
  • Digital/Print
    editor, Mark Lyte.
    Digital : Springer2016
    Print2016
    Microbial Endocrinology: An Ongoing Personal Journey -- New Trends and Perspectives in Evolutionary Considerations of Neurotransmitters in Microbial, Plant and Animal Cells -- Catecholamine-directed Epithelial Cell Interactions With Bacteria in the Intestinal Mucosa -- Modulation of the Interaction of Enteric Bacteria with Intestinal Mucosa -- Dietary Catechols and their Relationship to Microbial Endocrinology -- Mechanisms by Which Catecholamines Induce Growth in Gram-Negative and Gram-Positive Human Pathogens -- Molecular Profiling: Catecholamine Modulation of Gene Expression in Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium -- Microbial Endocrinology of Pseudomonas aeruginosa -- Interkingdom Chemical Signaling in Enterohemorrhagic Escherichia coli O157:H7 -- Role of Microbial Endocrinology in Periodontal Disease -- Staphylococci, Catecholamine Inotropes and Hospital-Acquired Infections -- Experimental Design Considerations for In Vitro Microbial -- The Role of the Microbiome in the Relationship of Asthma and Affective Disorders -- Psychological Stress, Immunity and Effects on Indigenous Flora -- Microbiome to Brain: Unraveling the Multidirectional Axes of Communication -- Mycologic Endocrinology.
  • Digital
    edited by Charles L. Wilson.
    CRCnetBASE2008
    Preface: Food--A Necessity and a Threat -- Editor -- Contributors -- Section I. Instances and Nature of Microbial Food Contamination -- 1. PulseNet and Emerging Foodborne Diseases / Efrain M. Ribot, Eija Hyytia-Trees, and Kara Cooper -- 2. Pathogenic Mechanisms of the Enterohemorrhagic
  • Digital
    edited by Andrei L. Osterman, Svetlana Y. Gerdes.
    Springer Protocols2008
    Overview of whole-genome essentiality analysis / Karen Joy Shaw -- Pt. I. Experimental protocols. IA. Populational genome-wide essentiality screens. Transposon-based strategies for the identification of essential bacterial genes / William S. Reznikoff and Kelly M. Winterberg -- Identification and analysis of essential genes in Haemophilus influenzae / Sandy M.S. Wong and Brian J. Akerley -- Transposon site hybridization in Mycobacterium tuberculosis / Jeffrey P. Murry ... [et al.] -- Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis / François Sanschagrin, Irena Kukavica-Ibrulj, and Roger C. Levesque -- Whole-genome detection of conditionally essential and dispensable genes in Escherichia coli via genetic footprinting / Michael D. Scholle and Svetlana Y. Gerdes -- Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis / Taeok Bae ... [et al.] -- Multipurpose transposon insertion libraries for large-scale analysis of gene function in yeast / Anuj Kumar -- IB. Systematic collections of knockout mutants. How to make a defined near-saturation mutant library. Case 1: Pseudomonas aeruginosa PAO1 / Michael A. Jacobs -- Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality / Nicole T. Liberati ... [et al.] -- The construction of systematic in-frame, single-gene knockout mutant collection in Escherichia coli K-12 / Tomoya Baba and Hirotada Mori -- The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12 / Tomoya Baba ... [et al.] -- A novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12 / Takeyoshi Miki, Yoshihiro Yamamoto, and Hideo Matsuda -- High-throughput creation of a whole-genome collection of yeast knockout strains / Angela M. Chu and Ronald W. Davis -- Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray / Pamela B. Meluh ... [et al.] -- IC. Genome minimization. Scarless engineering of the Escherichia coli genome / Tamás Fehér ... [et al.] -- Minimization of the Escherichia coli genome using the Tn5-targeted Cre/loxP excision system / Byung Jo Yu and Sun Chang Kim -- Construction of long chromosomal deletion mutants of Escherichia coli and minimization of the genome / Jun-ichi Kato and Masayuki Hashimoto -- ID. Conditional knockouts. Identification of essential genes in Staphylococcus aureus by construction and screening of conditional mutant library / Dezhong Yin and Yinduo Ji -- Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus / Allyn Forsyth and Liangsu Wang -- Introduction of conditional lethal amber mutations in Escherichia coli / Christopher D. Herring -- Pt. II. Bioinformatics. IIA. Statistics. Statistical methods for building random transposon mutagenesis libraries / Oliver Will -- Statistical evaluation of genetic footprinting data / Gábor Balázsi -- Modeling competitive outgrowth of mutant populations : why do essentiality screens yield divergent results? / Alexander I. Grenov and Svetlana Y. Gerdes -- Statistical analysis of fitness data determined by TAG hybridization on microarrays / Brian D. Peyser, Rafael Irizarry, and Forrest A. Spencer -- IIB. Data integration and modeling. Profiling of Escherichia coli chromosome database / Yukiko Yamazaki, Hironori Niki, and Jun-ichi Kato -- Gene essentiality analysis based on DEG, a database of essential genes / Chun-Ting Zhang and Ren Zhang -- Detection of essential genes in Streptococcus pneumoniae using bioinformatics and allelic replacement mutagenesis / Jae-Hoon Song and Kwan Soo Ko -- Design and application of genome-scale reconstructed metabolic models / Isabel Rocha, Jochen Förster, and Jens Nielsen -- Predicting gene essentiality using genome-scale in silico models / Andrew R. Joyce and Bernhard Ø. Palsson -- Comparative approach to analysis of gene essentiality / Andrei L. Osterman and Svetlana Y. Gerdes.
  • Digital
    editor-in-chief, Anthony P. Moran ; editors, Otto Holst, Patrick J. Brennan, Mark von Itzstein.
    ScienceDirect2009
  • Digital
    edited by Qiong Cheng.
    Springer Protocols2012
    Screening for cellulases with industrial value and their use in biomass conversion / Julia Jüergensen, Nele Ilmberger, and Wolfgang R. Streit -- Reversal of NAD(P)H cofactor dependence by protein engineering / Sabine Bastian and Frances H. Arnold -- Quantifying plasmid copy number to investigate plasmid dosage effects associated with directed protein evolution / Samuel Million-Weaver [and others] -- High isoprenoid flux Escherichia coli as a host for carotenoids production / Wonchul Suh -- Mutagenic inverted repeats assisted genome engineering (MIRAGE) in Saccharomyces cerevisiae : deletion of gal7 / Nikhil U. Nair and Huimin Zhao -- Creation of new metabolic pathways or improvement of existing metabolic enzymes by in vivo evolution in Escherichia coli / Isabelle Meynial-Salles and Philippe Soucaille -- Bioluminescent reporter genes for promoter discovery / Tina K. Van Dyk -- Recombination-based DNA assembly and mutagenesis methods for metabolic engineering / Xiquan Liang [and others] -- Ethanol-tolerant gene identification in Clostridium thermocellum using pyro-resequencing for metabolic engineering / Shihui Yang, Dawn M. Klingeman, and Steven D. Brown -- Use of proteomic tools in microbial engineering for biofuel production / Shaoming Mao [and others] -- Metabolic engineering of antibiotic-producing Actinomycetes using in vitro transposon mutagenesis / Andrew R. Reeves and J. Mark Weber -- Use FACS sorting in metabolic engineering of Escherichia coli for increased peptide production / Qiong Cheng [and others] -- Using flux balance analysis to guide microbial metabolic engineering / Kathleen A. Curran, Nathan C. Crook, and Hal S. Alper -- Using an advanced microfermentor system for strain screening and fermentation optimization / Dongming Xie -- Rapid strain evaluation using dynamic DO-stat fed-batch fermentation under scale-down conditions / Jun Sun -- Preparation and evaluation of lignocellulosic biomass hydrolysates for growth by ethanologenic yeasts / Ying Zha [and others] -- Engineering whole-cell biosensors with no antibiotic markers for monitoring aromatic compounds in the environment / Aitor de las Heras and Víctor de Lorenzo -- Metabolic engineering for acetate control in large scale fermentation / Yong Tao, Qiong Cheng, and Alexander D. Kopatsis -- Minimization and prevention of phage infections in bioprocesses / Marcin Los.
  • Digital
    edited by Ipek Kurtböke.
    ScienceDirect2017
    Planctomycetes : new models for microbial cells and activities / John A. Fuerst -- A flavor of prokaryotic taxonomy : systematics revisited / Paul De Vos, Fabiano Thompson, Cristiane Thompson and Jean Swings -- Bioactive actinomycetes : reaching rarity through sound understanding of selective culture and molecular diversity / Ipek Kurböke -- Microbial resources for global sustainability / Jim Philp and Ronald Atlas -- Modern natural products drug discovery and its relevance to biodiversity conservation / C. Benjamin Naman, Christopher A. Leber and William H. Gerwick -- Hydrocarbon-oxidizing bacteria and their potential in eco-biotechnology and bioremediation / Irena B. Ivshina, Maria S. Kuyukina and Anastasiya V. Krivoruchko -- An overview of the industrial aspects of antibiotic discovery / Evan Martens and Arnold L. Demain -- Accessing marine microbial diversity for drug discovery/ Lynette Bueno Pérez and William Fenical -- Cryptic pathways and implications for novel drug discovery / Kozo Ochi -- The Nagoya protocol applied to microbial genetic resources / Philippe Desmeth -- Fungal genetic resources for biotechnology / Kevin McCluskey -- Industrial culture collections : gateways from microbial diversity to applications / Olga Genilloud -- An overview of biological resource center-maintenance of microbial resources and their management / Ken-ichiro Suzuki -- IP and the Budapest Treaty : depositing biological material for patent purposes / Vera Bussas, Avinash Sharma and Yogesh Shouche -- Biosafety, transport, and related legislation concerning microbial resources : an overview / Vera Bussas.
  • Digital
    Charles Hagedorn, Anicet R. Blanch, Valerie J. Harwood, editors.
    Springer2011
    Chapter 1: Overview -- Chapter 2: Performance Criteria -- Chapter 3: Library-dependent Source Tracking Methods -- Chapter 4: Library-Independent Source Tracking Methods -- Chapter 5: Viruses as Tracers of Fecal Contamination -- Chapter 6: Phage Methods -- Chapter 7: Pathogenic Protozoa -- Chapter 8: Chemical-Based Fecal Source Tracking Methods -- Chapter 9: Statistical Approaches for Modeling in Microbial Source Tracking -- Chapter 10: Mitochondrial DNA as Source Tracking Markers of Fecal Contamination -- Chapter 11: Community Analysis-Based Methods -- Chapter 12: Public Perception of and Public Participation in Microbial Source Tracking -- Chapter 13: Use of Microbial Source Tracking in the Legal Arena: Benefits and Challenges -- Chapter 14: Applications of Microbial Source Tracking in the TMDL Process -- Chapter 15: Relating MST Results to Fecal Indicator Bacteria, Pathogens, and Standards -- Chapter 16: Minimizing Microbial Source Tracking at All Costs -- Chapter 17: Environmental Persistence and Naturalization of Fecal Indicator Organisms -- Chapter 18: Agricultural and Rural Watersheds -- Chapter 19: Case Studies of Urban and Suburban Watersheds -- Chapter 20: Beaches and Coastal Environmenta -- Chapter 21: Source tracking in Australia and New Zealand: Case Studies -- Chapter 22: Microbial Source Tracking in China and Developing Nations -- Chapter 23: A National Security Perspective of Microbial Source Tracking -- Chapter 24: Applications of Quantitative Microbial Source Tracking (QMST) and Quantitative Microbial Risk Assessment (QMRA) -- Chapter 25: Food Safety and Implications for Microbial Source Tracking -- Chapter 26: Training Future Scientists: Teaching Microbial Source Tracking (MST) to Undergraduates -- Index.
  • Digital
    edited by Colin Harwood, Anil Wipat.
    ScienceDirect2013
    Computational intelligence in the design of synthetic microbial genetic systems / Jennifer S. Hallinan -- Constraints in the design of the synthetic bacterial chassis / Antoine Danchin and Agnieszka Sekowska -- Social dimensions of microbial synthetic biology / Jane Calvert, Emma Frow -- Bacillus subtilis: model gram-positive synthetic biology chassis / Colin R. Harwood, Suzanne Pohl, Wendy Smith, Anil Wipat -- Engineering microbial biosensors / Lisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont, Karen Polizzi -- Noise and stochasticity in gene expression: a pathogenic fate determinant / Mikkel Girke Jørgensen, Renske van Raaphorst, Jan-Willem Veening -- Platforms for genetic design automation / Chris J. Myers.
  • Digital
    edited by Ali Navid.
    Springer Protocols2012
    pt. I. Sample preparation and identification. -- 1. Flow cytometry in environmental microbiology: a rapid approach for the isolation of single cells for advanced molecular biology analysis / Belinda C. Ferrari, Tristrom J. Winsley, Peter L. Bergquist, and Josie Van Dorst ; 2. Pressure cycling technology in systems biology / Bradford S. Powell, Alexander V. Lazarev, Greta Carlson, Alexander R. Ivanov, and David A. Rozak ; 3. Targeted isolation of proteins from natural microbial communities living in an extreme environment / Steven W. Singer ; 4. Bacterial identification and subtyping using DNA microarray and DNA sequencing / Sufian F. Al-Khaldi, Magdi M. Mossoba, Marc M. Allard, E. Kurt Lienau, and Eric D. Brown -- pt. II. Experimental genomic analysis. -- 5. Genetic manipulation of the obligate chemolithoautotrophic bacterium Thiobacillus denitrificans / Harry R. Beller, Tina C. Legler, and Stacie R. Kane ; 6. Genome-wide mapping of the binding sites of proteins that interact with DNA / Stephen Spiro -- pt. III. Protein and lipid analysis. -- 7. Microbial proteomics using mass spectrometry / Harry B. Hines ; 8. Fourier transform infrared spectroscopy for molecular analysis of microbial cells / Jesús J. Ojeda and Maria Dittrich -- pt. IV. Metabolomic analyses. -- 9. Mass spectrometery-based microbial metabolomics / Edward E.K. Baidoo, Peter I. Benke, and Jay D. Keasling ; 10. Fast sampling of the cellular metabolome / Walter M. Van Gulik, Andre B. Canelas, Hilal Taymaz-Nikeel, Rutger D. Douma, Lodewijk P. de Jonge, and Joseph J. Heijnen -- pt. V. -- 11. Metabolic pathway determination and flux analysis in nonmodel microorganisms through ¹³C-isotope labeling / Xueyang Feng, Wei-Qin Zhuang, Peter Colletti, and Yinjie J. Tang ; 12. Biolog phenotype microarrays / April Shea, Mark Wolcott, Simon Daefler, and David A. Rozak ; 13. NanoSIP: nanoSIMS applications for microbial biology / Jennifer Pett-Ridge and Peter K. Weber -- pt. VI. Kinetic modeling of cellular processes -- 14. Electrophysiological-metabolic modeling of microbes: applications in fuel cells and environment analysis / Max Fontus and Peter Ortoleva ; 15. Simulating microbial systems: addressing model uncertainty/incompleteness via multiscale and entropy methods / A. Singharoy, H. Joshi, S. Cheluvaraja, Y. Miao, D. Brown, and P. Ortoleva -- pt. VII. -- 16. Bacterial genome annotation / Nicholas Beckloff, Shawn Starkenburg, Tracey Freitas, and Patrick Chain ; 17. LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data / Eleanor C. Saunders, James I. MacRae, Thomas Naderer, Milica Ng, Malcolm J. McConville, and Vladimir A. Likić ; 18. Development of constraint-based system-level models of microbial metabolism / Ali Navid ; 19. Complex network analysis in microbial systems: theory and examples / Zahra Zavareh and Eivind Almaas ; 20. Modeling a minimal cell / Michael L. Shuler, Patricia Foley, and Jordan Atlas.
  • Digital
    edited by Otto Holst.
    Springer Protocols2011
    Part I: Bacterial protein toxins -- Detection of bacterial protein toxins by solid phase magnetic immunocapture and mass spectrometry / Gabriella Pocsfalvi and Gitta Schlosser -- Sensitive and rapid detection of cholera toxin-producing Vibrio cholerae using loop-mediated isothermal amplification / Wataru Yamazaki -- Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA / Karine Bagramyan and Markus Kalkum -- Examination of Bacillus anthracis spores by multiparameter flow cytometry / William C. Schumacher [and others] -- A cell-based fluorescent assay to detect the activity of shiga toxin and other toxins that inhibit protein synthesis / Shane Massey, Beatriz Quiñones, and Ken Teter -- Use of a vero cell-based fluorescent assay to assess relative toxicities of shiga toxin 2 subtypes from Escherichia coli / Beatriz Quiñones and Michelle S. Swimley -- Molecular methods: chip assay and quantitative real-time PCR: in detecting hepatotoxic cyanobacteria / Anne Rantala-Ylinen, Hanna Sipari, and Kaarina Sivonen -- Part II: Endotoxins -- Capillary electrophoresis chips for fingerprinting endotoxin chemotypes from whole-cell lysates / Béla Kocsis [and others] -- Isolation of smooth-type lipopolysaccharides to electrophoretic homogeneity / Elder Pupo -- A method for unobtrusive labeling of lipopolysaccharides with quantum dots / Carlos Morales-Betanzos, Maria Gonzalez-Moa, and Sergei A. Svarovsky -- Fluorescence-based methods to assay inhibitors of lipopolysaccharide synthesis / Marcy Hernick -- Micromethods for lipid a isolation and structural characterization / Martine Caroff and Alexey Novikov -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. I. LPS activation with cyanogen bromide / Fernando Battaglini and Diego Pallarola -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. II. LPS activation with a cyanopyridinium agent / Fernando Battaglini and Diego Pallarola -- Part III: Mold fungus toxins -- Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells / Nicholas C. Zitomer and Ronald T. Riley -- Determination of fumonisins B₁ and B₂ in maize food products by a new analytical method based on high-performance liquid chromatography and fluorimetric detection with post-column derivatization / Marilena Muscarella [and others] -- A confirmatory method for aflatoxin M₁ determination in milk based on immunoaffinity cleanup and high-performance liquid chromatography with fluorometric detection / Marilena Muscarella [and others] -- Simultaneous determination of aflatoxins B₁, B₂, G₁, and G₂ in foods and feed materials / Marilena Muscarella [and others] -- Highly sensitive PCR-based detection specific to Aspergillus flavus / Amaia González-Salgado -- A rapid enzymatic method for aflatoxin B detection / Danila Moscone, Fabiana Arduini, and Aziz Amine.
  • Digital
    Jeremy Nuttall, editor.
    Springer2014
    One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
  • Print
    Todd A. Swanson, Sandra I. Kim, Olga E. Flomin.
    Status: Not Checked OutLane Catalog Record
    v. 1. Virology, immunology, parasitology, mycology -- v. 2. Bacteriology.
  • Print
    James D. Kettering.
    Status: Not Checked OutLane Catalog Record
  • Print
    [edited by] Matthew B. Grisham.
    Status: Not Checked OutLane Catalog Record
    High Yield Facts -- Physiology and Molecular Microbiology -- Virology -- Bacteriology -- Rickettsiae, Chlamydiae, and Mycoplasms -- Mycology -- Parasitology -- Immunology.
  • Digital
    Steven L. Percival, editor.
    Springer2009
  • Digital
    Springerv. 1-, 2006-
  • Digital
    Steven L. Percival, Marylynn V. Yates, David W. Williams, Rachel M. Chalmers, Nicholas F. Gray.
    ScienceDirect2014
    The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus. Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen. Contains new material on antimicrobial resistance and biofilms. Covers drinking water and both marine and freshwater recreational bathing waters.
  • Digital
    edited by Steven Percival and Keith Cutting.
    CRCnetBASE2010
    An introduction to the world of microbiology and biofilmology / Steven L. Percival, John G. Thomas, and David Williams -- Human skin and microbial flora / Rose A. Cooper and Steven L. Percival -- An introduction to wounds / Michel H.E. Hermans and Terry Treadwell -- Burn wound management / Michel H.E. Hermans -- Cell biology of normal and impaired healing / Keith Moore -- The microbiology of wounds / Steven L. Percival and Scott E. Dowd -- Types of wounds and infections / Randall D. Wolcott ... [et al.] -- Biofilms and significance to wound healing / Keith F. Cutting ... [et al.] -- Wounds, enzymes, and proteases / Steven L. Percival and Christine A. Cochrane -- Wound healing immunology and biofilms / Emma J. Woods ... [et al.] -- Antimicrobial interventions for wounds / Steven L. Percival, Rose A. Cooper, and Benjamin A. Lipsky -- Wound dressings and other topical treatment modalities in bioburden control / Richard White -- Factors affecting the healing of chronic wounds : an iconoclastic view / Marissa J. Carter and Caroline E. Fife.
  • Print
    S. James Booth.
    Status: Not Checked OutLane Catalog Record
    Basic bacteriology -- Genetics -- Antimicrobial agents -- General medical microbiology -- Gram-positive cocci -- Gram-negative cocci -- Gram-positive and acid-fast bacilli -- Gram-negative bacilli -- Anaerobes -- Spirochetes -- Atypical pathogenic bacteria : mycoplasma, rickettsia, ehrlichia, anaplasma, chlamydia, and chlamydophila -- Virology -- Mycology -- Parasitology -- Random pearls.
  • Digital
    Committee on Microbiomes of the Built Environment: from Research to Application, Board on Life Sciences, Board on Environmental Studies and Toxicology, Board on Infrastructure and the Constructed Environment, Division on Earth and LIfe Studies, Health and Medicine Division, Division on Engineering and Physical Sciences, National Academy of Engineering.
    NCBI Bookshelf2017
    "People's desire to understand the environments in which they live is a natural one. People spend most of their time in spaces and structures designed, built, and managed by humans, and it is estimated that people in developed countries now spend 90 percent of their lives indoors. As people move from homes to workplaces, traveling in cars and on transit systems, microorganisms are continually with and around them. The human-associated microbes that are shed, along with the human behaviors that affect their transport and removal, make significant contributions to the diversity of the indoor microbiome. The characteristics of "healthy" indoor environments cannot yet be defined, nor do microbial, clinical, and building researchers yet understand how to modify features of indoor environments--such as building ventilation systems and the chemistry of building materials--in ways that would have predictable impacts on microbial communities to promote health and prevent disease. The factors that affect the environments within buildings, the ways in which building characteristics influence the composition and function of indoor microbial communities, and the ways in which these microbial communities relate to human health and well-being are extraordinarily complex and can be explored only as a dynamic, interconnected ecosystem by engaging the fields of microbial biology and ecology, chemistry, building science, and human physiology. This report reviews what is known about the intersection of these disciplines, and how new tools may facilitate advances in understanding the ecosystem of built environments, indoor microbiomes, and effects on human health and well-being. It offers a research agenda to generate the information needed so that stakeholders with an interest in understanding the impacts of built environments will be able to make more informed decisions"--Publisher's description.
  • Digital
    edited by Martin H. Floch, Yehuda Ringel, W. Allan Walker.
    ScienceDirect2017
  • Digital/Print
    Andreas Schwiertz, editor.
    Digital : Springer2016
    Print2016
    Preface -- Chapter 1. Microbiota: what does it mean (historic considerations- Schwiertz et. al) -- Chapter 2. Studying the human microbiota -- Alan Walker -- Chapter 3. The gut microbiota and their metabolites: potential implications for the host epigenome -- Mona Mischke and Torsten Plösch -- Chapter 4. The Oral Microbiota -- Nicole B. Arweiler, Lutz Netuschil -- Chapter 5. Skin Microbiota -- Markus Egert and Rainer Simmering -- Chapter 6. Vaginal Microbiota -- Werner Mendling -- Chapter 7. Gastrointestinal Microbiota -- Hermie J.M. Harmsen and Marcus. C. de Goffau -- Chapter 8. How to manipulate the Microbiota by Probiotics -- Verena Grimm and Christian U. Riedel -- Chapter 9. How to manipulate the Microbiota by Prebiotics -- Petra Louis, Harry J. Flint and Catherine Michel. Chapter 10. Microbiota transplantation -- Susana Fuentes, Ph.D. and Willem M. de Vos, Prof. Ph.D -- Index. .
  • Digital
    edited by Brian Flannigan, Robert A. Samson, J. David Miller.
    CRCnetBASE2011
    Machine generated contents note: ch. 1 Microorganisms in air -- 1.1.Microorganisms in outdoor air / B. Flannigan -- 1.2.Microorganisms in indoor air / B. Flannigan -- 1.3.Pollen in indoor air / A. Rantio-Lehtimaki -- ch. 2 Microorganisms in homes and work environments -- 2.1.Microbial growth in indoor environments / J.D. Miller -- 2.2.Bacteria and other bioaerosols in industrial workplaces / J.R.M. Swan -- 2.3.Remediation and control of microbial growth in problem buildings / P.R. Morey -- ch. 3 Airborne microorganisms and disease -- 3.1.Allergenic microorganisms and hypersensitivity / J.H. Day -- 3.2.Occupational respiratory disease: hypersensitivity pneumonitis and other forms of interstitial lung disease / B. Flannigan -- 3.3.Respiratory tract infections caused by indoor fungi / R.C. Summerbell -- ch. 4 Microbiological investigation of indoor environments -- 4.1.Mycological investigations of indoor environments / J.D. Miller -- 4.2.Molecular methods for bioaerosol characterization / J.A. Scott -- 4.3.Isolation and identification of fungi / J. Houbraken -- 4.4.Analysis of microbial volatile organic compounds / T.J. Ryan -- 4.5.Analysis for toxins and inflammatory compounds / J.D. Miller -- 4.6.Interpreting sampling data in investigations of indoor environments: selected case studies / P.R. Morey -- ch. 5 Common and important species of Actinobacteria and fungi in indoor environments -- Common and important species of fungi and actinomycetes in indoor environments / J.D. Miller -- Descriptions and illustrations of common fungi and actinomycetes.
  • Digital
    Richard V. Goering, Hazel M. Dockrell, Mark Zuckerman, Peter L. Chiodini, Ivan M. Roitt.
    ClinicalKey2013
    Using a clinically relevant, systems-based approach, this medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Richard Goering makes this complex subject simple to understand and remember. 150 multiple choice review questions. "Pathogen Parade" and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way. Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
  • Digital
    Lena Pernas.
    Protozoan and prokaryotic pathogens are able to recruit mitochondria to the vacuoles in which they grow (Friis, 1972; Horwitz, 1983), in mammalian and protozoan cells. The functional significance of the recruitment and association of this phenomenon in Toxoplasma-infected cells has been a subject of speculation since it was first described in the early 1970s (Jones et al., 1972). Previous work has proposed Toxoplasma gondii rhoptry protein 2 (Sinai and Joiner, 2001) as the physical link that tethers host mitochondria to the parasitophorous vacuole and conventional wisdom since has suggested that mitochondrial recruitment served a nutritional function supplementary to the parasite. A recent analysis of the ROP2 structure raised questions about this model ((Labesse et al., 2009; Reese and Boothroyd, 2009). Chapter II describes the effect of deleting ROP2 on mitochondrial association while Chapter III describes the identification of a novel mediator of mitochondrial association, Mitochondrial association factor I (MAF1) and experiments that attempt to answer the role of this remarkable phenomenon in the host-pathogen interaction. Chapter IV describes a project undertaken to determine the impact of Toxoplasma gondii infection in humans acutely and chronically infected in different geographical regions. Chapter V concludes with a discussion of future directions for further characterization of host mitochondrial association in the host response to microbial infection.
  • Digital
    edited by Sid M. Becker.
    ScienceDirect2017
    Molecular simulations of complex membrane models / D. Jefferies and S. Khalid -- Microbial strategies for oil biodegradation / G.E. Kapellos -- Modeling and measurement of biomolecular transport and sensing in microfluidic cell culture and analysis systems / J.F. Wong, C.A. Simmons and E.W.K. Wong -- Coupling microscale transport and tissue mechanics / M. Marino, G. Pontrelli, G. Vairo, and P. Wriggers -- Modeling cystic fibrosis and mucociliary clearance / R. Chatelin, D. Anne-Archard, M. Murris-Espin, D. Sanchez, M. Thiriet, A. Didier, and P. Poncet -- Intracellular microfluid transportation in fast growing pollen tubes / S. Liu, H. Liu, M. Lin, F. Xu, and T.J. Lu -- Microorganisms and their response to stimuli / R.J. Clarke -- Nano-swimmers in lipid-bilayer membranes / M.-J. Huang and A. Mikhailov -- Phase field modeling of Inhomogeneous biomembranes in flow / S. Aland -- Modeling and experimental analysis of thermal therapy during short pulse laser irradiation / S. Miller, C. Gross Jones, and K. Mitra -- Micro-scale bio-heat diffusion using green's functions / F. De Monte and A. Haji-Sheikh -- Microstructural influences on growth and transport in biological tissue / L. Irons, J. Collis, and R.D. O'Dea -- How dense core vesicles are delivered to axon terminals / I.A. Kuznetsov and A.V. Kuznetsov -- Modeling of food digestion / S. Marze.
  • Digital
    Lorenzo Drago, editor.
    Springer2017
    The concept of biofilm-related implant malfunction and "low-grade infection" -- Mechanisms of bacterial colonization of implants and host response -- Animal models of implant-related low-grade infections, a twenty-year review -- Microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma -- Antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Prosthetic joint infections and cost analysis? -- Algorithm to diagnose delayed and late PJI: role of joint aspiration -- Erratum: microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- Erratum: antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Index.
  • Digital
    Erica Machlin Cox.
    Hepatitis C virus (HCV) is a global health problem, infecting approximately 2% of the world's population. The virus is hepatotropic, replicating in liver cells, and its only known hosts are humans and chimpanzees. HCV is an unusual virus in that it requires the liver-specific host microRNA (miRNA) miR-122 for HCV RNA accumulation. Though the precise mechanism by which miR-122 upregulates HCV RNA is still under investigation, it is known that miR-122 must bind to two adjacent sites in the 5' end of the HCV genome. In this dissertation, a stepwise mutational analysis of the entire sequence of miR-122 was performed to identify residues important for HCV RNA accumulation. All mutant miRNAs were tested in canonical miRNA reporter assays and in HCV RNA accumulation assays. The identities of two nucleotides within miR-122, at positions 15 and 16, were shown to be dispensable for canonical miRNA and siRNA activity but required for HCV RNA accumulation. Compensatory mutations in the HCV genome upstream of the original binding sites uncovered supplementary binding sites for nucleotides 15 and 16 of miR-122. This analysis led to a new model for miR-122-HCV RNA interactions. To further define the requirements of HCV for miR-122, we investigated whether the predecessor of mature miR-122, a long hairpin precursor designated pre-miR-122, was also able to mediate HCV RNA accumulation. The function of pre-miR-122 was tested in miRNA, siRNA, and HCV RNA accumulation assays. Inhibition of pre-miR-122 processing was achieved by substituting deoxyribonucleotides into the loop of pre-miR-122 to prevent Dicer-mediated cleavage. Full-length pre-miR-122 was demonstrated to be functional in miRNA and siRNA assays and to be sufficient for HCV RNA accumulation. Pre-miR-122 also required traditional components of the RNA-induced silencing complex (RISC) for activity. Taken together, this research has uncovered novel requirements of miR-122 for HCV RNA accumulation. Components shown to be dispensable for canonical miRNA interactions were necessary for this unusual microRNA-target RNA interaction. Uncovering hepatitis C virus's stringent requirements for the mature and precursor forms of miR-122 will pave the way for new antiviral therapies targeting a host factor.
  • Digital
    Falk Nimmerjahn, editor.
    Springer2014
    This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • Digital
    edited by Dongyou Liu.
    CRCnetBASE2011
    Pt. 1. Ascomycota -- pt. 2. Bastidiomycota -- pt. 3. Entomohpthoromycotina and Muscoromyotina -- pt. 4. Microsporidia -- pt. 5. Oomycota, Chlorophyta, and Mesomycetozoea -- pt. 6. Panfungal and drug resistance detection.
  • Digital
    Youssuf Gherbawy, Kerstin Voigt, editors.
    Springer2010
  • Digital
    edited by Hubert Hilbi.
    Springer2014
    Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • Digital
    Jonathan Wiley Jones.
    Francisella tularensis is a facultative intracellular pathogen that causes the disease tularemia. The ability of F. tularensis to escape phagosomal degradation and replicate in the macrophage cytosol is central to its pathogenesis. The macrophage responds to the presence of cytosolic F. tularensis with the production of type-I interferons (IFN) and subsequent activation of the inflammasome. We conducted a forward genetic screen of a F. novicida transposon library to identify mutants that resulted in an increased or decreased cytosolic response in macrophages. We identified 164 F. novicida mutants that lead to increased type-I IFN production and inflammasome activation in macrophages. We also identified 74 mutants that resulted in decreased type-I IFN and inflammasome responses in macrophages. Finally, we identified AIM2 as the host receptor responsible for inflammasome activation in response to cytosolic F. novicida. We showed that lysing cytosolic F. novicida leads to release of bacterial DNA that triggers type-IFN through a pathway involving the adaptor STING. STING-dependent type-I IFN production increases the expression of AIM2, which complexes with the bacterial DNA and initiates inflammasome activation. We further demonstrate that AIM2 is critical for innate immunity to F. novicida infection in vivo. Thus we identified a novel bacterial ligand and novel cytosolic sensing components that play a role in the host defense to bacterial infections.
  • Digital
    editors in chief: David H. Persing, Fred C. Tenover; editors: Randall T. Hayden, Margareta Ieven, Melissa B. Miller, Frederick S. Nolte, Yi-Wei Tang, Alex van Belkum.
    Am Soc Microbiol2016
    Presents the latest molecular diagnostic techniques to support clinical care and basic and clinical research. The authors-all experienced researchers and diagnosticians-have conducted a comprehensive review and evaluation of this rapidly evolving field and written a book that offers a broad range of practical guidance and techniques. Encapsulates the current state of the science and points to new avenues for research that will broaden the application and usefulness of molecular diagnostics.
  • Digital
    Poornima Parameswaran.
    Small RNAs that are 19-30 nucleotides in length use the genetic information encoded in their sequence to effect gene regulation in a sequence-directed manner. Infections with RNA viruses in plants, worms and flies generate short viral-derived RNAs ("vsRNAs") that map to the genome of the infecting virus. The regulated production of these vsRNAs and their engagement by the immune apparatus is essential for inhibiting viral growth, making vsRNAs important components of antiviral immunity in these organisms. RNA virus-derived vsRNA-mediated gene silencing is yet to be demonstrated in mammalian systems. We investigated diverse RNA virus-mammalian systems, and characterized changes in small RNA populations that occur during viral infection in animal cells using high-throughput sequencing. Due to the large number of samples to be analyzed, we designed DNA barcodes to 'tag' RNA samples from individual experiments, which facilitated sequencing in parallel from multiple samples. Our work demonstrated the generality of RNA virus-derived vsRNA production, and the ability of the cellular short RNA apparatus to engage these vsRNAs in worms during Flock House Virus replication, and in mammalian cells during infections with Hepatitis C, Polio, Dengue, Vesicular Stomatitis or West Nile virus. In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host-encoded small RNA (miRNA) profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We found evidence for populations of vsRNAs that exist as duplexed small interfering RNAs ("siRNAs; " effectors of gene silencing) with zero to three nucleotide 3' overhangs. We also observed strand-selective loading of siRNAs onto Argonaute complexes, which are mediators of gene silencing. We quantitated the capacity of these HCVrep-derived vsRNAs to down-regulate target mRNAs in a sequence-specific manner in mammalian systems. We found that abundant HCVrep vsRNAs are not capable of mediating robust silencing (i.e. 2-fold or higher) of Luciferase reporters that have been engineered with vsRNA targets. Additionally, over-expression of siRNAs corresponding to five abundant vsRNAs failed to enhance silencing of Hepatitis C Virus mRNA. These results complement each other and suggest that in mammalian hosts, the virus may coexist with an abundant population of vsRNAs. Questions still remain as to whether robust gene silencing may be achieved by the cooperative action of abundant vsRNAs, or if abundant vsRNAs specifically inhibited from functioning in gene silencing, or alternatively, if they have novel roles in pathways distinct from gene silencing.
  • Digital
    Susanne Modrow, Dietrich Falke, Uwe Truyen, Hermann Schätzl.
    Springer2013
    The book gives a comprehensive overview on the knowledge of virus infection relevant for humans and animals. For each virus family the molecular details of the virus particle and the viral replication cycle are described. In the case of virus types with relevance for human and/or animal health the data on molecular biology, genetics and virus-cell interaction are combined with those concerning, pathogenesis, epidemiology, clinics, prevention and therapy.
  • Digital
    Brian Henderson, editor.
    Springer2013
  • Digital
    edited by Brian Henderson.
    Wiley2017
    What is protein moonlighting and why is it important? / Constance J. Jeffery -- Exploring structure-function relationships in moonlighting proteins / Sayoni Das, Ishita Khan, Daisuke Kihara, Christine Orengo -- Overview of protein moonlighting in bacterial virulence / Brian Henderson -- Moonlighting proteins as cross-reactive autoantigens / Wim van Eden -- Chaperonin 60 paralogues in mycobacterium tuberculosis and tubercle formation / Brian Henderson -- Legionella pneumophila chaperonin 60 an extra- and intra-cellular moonlighting virulence-related factor / Karla N. Valenzuela-Valderas, Angela L. Riveroll, Peter Robertson, Lois E. Murray, and Rafael A. Garduño -- An overview of peptidylprolyl isomerases in bacterial virulence / Brian Henderson -- GAPDH : a multifunctional moonlighting protein in eukaryotes and prokaryotes / Michael A. Sirover -- Streptococcus pyogenes GAPDH : a cell surface major virulence determinant / Vijay Pancholi -- Group B streptococcus GAPDH and immune evasion / Paula Ferreira and Patrick Trieu-Cuot -- Mycobacterium tuberculosis cell surface gapdh functions as a transferrin receptor / Vishant M Borradia, Manoj Raje, Chaaya Iyengar -- Gapdh and probiotic organisms / Hideki Kinoshita -- Impact of streptococcal enolase in virulence / Marcus Fulde and Simone Bergmann -- Streptococcal enolase and immune evasion / Masaya Yamaguchi and Shigetada Kawabata -- Borrelia burgdorferi enolase and plasminogen binding / Catherine A. Brissette -- Triosephosphate isomerase from staphylococcus aureus and plasminogen receptors on microbial pathogens / Reiko Ikeda, Tomoe Ichikawa -- Moonlighting functions of bacterial fructose-1,6 bisphosphate-aldolases / Neil J Oldfield, Fariza Shams, Karl G Wooldridge and David PJ Turner -- Pyruvate dehydrogenase and plasminogen binding in mycoplasmas / Anne Gründel, Kathleen Friedrich, Melanie Pfeiffer, Enno Jacobs, Roger Dumke -- Unexpected interactions of leptospiral ef-tu proteins / Natalia Salazar and Angela Barbosa -- Mycobacterium tuberculosis antigen 85 family proteins : mycolyl transferases and matrix-binding adhesins / Christopher P. Ptak, Chih-Jung Kuo, and Yung-Fu Chang -- Miscellaneous il-1[beta]-binding proteins of aggregatibacter actinomycetemcomitans / Riikka Ihalin -- Bacteriophage moonlighting in the control of bacterial pathogenicity / Janine Bowring, Alberto Marina, José R. Penadés and Nuria Quiles-Puchalt -- Viral entry glycoproteins and viral immune evasion / Jonathan D. Cook and Jeffrey E. Lee.
  • Digital
    David Conroy.
    CRCnetBASE2010
    Why the investigation was started -- Materials and methodology -- Evidence not recorded on videotape -- The phenomenon of the disappearing hair follicles -- Particles entering the eyes -- Particles exiting the eyes -- A substance that transverses the optic globe -- The irregular iris -- Particles that exit the feet -- Particles that enter the feet -- The microorganism mobility : an internal propulsion system -- Green feet illuminate the role of the epidermis in the life-cycle of the microorganism -- Coated hairs under the microscope -- The micro organism possibly growing on a piece of cocaine -- A summary of the observations -- The structure of the microorganism -- A model accounting for the observed phenomena -- Is there a cure? -- Future considerations : a microorganism as an etiology for delusional parasitosis.
  • Digital
    [edited by] José Pérez-Martín, Antonio Di Pietro.
    Springer2012
    This book combines state-of-the-art expertise from a variety of diverse pathogen model systems to provide an update to our current understanding of the regulation of fungal morphogenesis as a key determinant of pathogenicity in fungi.
  • Digital
    Alice Prince, editor.
    Springer2013
    In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • Digital
    edited by Tanya Parish and David M. Roberts.
    Springer Protocols2015
    Whole-genome sequencing for comparative genomics and de novo genome assembly / Andrej Benjak, Claudia Sala, and Ruben C. Hartkoorn -- Whole-transcriptome sequencing for high-resolution transcriptomic analysis in mycobacterium tuberculosis / Andrej Benjak, Claudia Sala, and Ruben C. Hartkoorn -- RNA sequencing for transcript 5'-end mapping in mycobacteria / Scarlet S. Shell [and 3 otherst] -- Fractionation and analysis of mycobacterial proteins / Megan C. Lucas [and 6 others] -- Lipid and lipoarabinomannan isolation and characterization / Marie-Antoinette Lanéelle, Jérôme Nigou, and Mamadou Daffé -- Metabolomics of mycobacterium tuberculosis / Madhumitha Nandakumar [and 3 others] -- Electroporation of mycobacteria / Renan Goude, David M. Roberts, and Tanya Parish -- Targeted gene knockout and essentiality testing by homologous recombination / Krishnamoorthy Gopinath, Digby F. Warner, and Valerie Mizrahi -- Construction of conditional knockdown mutants in mycobacteria / Dirk Schnappinger, Kathryn M. O'Brien, and Sabine Ehrt -- Mycobacterial recombineering / Kenan C. Murphy, Kadamba Papavinasasundaram, and Christopher M. Sassetti -- In vitro models that utilize hypoxia to induce non-replicating persistence in mycobacteria / Charles D. Sohaskeyand Martin I. Voskuil -- Genetic dissection of mycobacterial biofilms / Anil K. Ojha, William R. Jacobs Jr., and Graham F. Hatfull -- Measuring efflux and permeability in mycobacteria / Liliana Rodrigues, Miguel Viveiros, and José A. Aínsa -- Single-cell analysis of mycobacteria using microfluidics and time-lapse microscopy / Neeraj Dharand and Giulia Manina -- Antimicrobial susceptibility testing for Mycobacterium sp. / Delia Blanco-Ruano [and 6 others] -- Determination of compound kill kinetics against mycobacterium tuberculosis / Julie Early and Torey Alling -- Microplate alamar blue assay (MABA) and low oxygen recovery assay (LORA) for mycobacterium tuberculosis Sanghyun Cho, Hyung Sup Lee, and Scott Franzblau -- Multi-stress model for high throughput screening against non-replicating mycobacterium tuberculosis / Ben Gold, Thulasi Warrier, and Carl Nathan -- Isolation and characterization of compound-resistant isolates of mycobacterium tuberculosis / Theresa O'Malley and Eduard Melief -- Macrophage infection models for mycobacterium tuberculosis / Benjamin K. Johnson and Robert B. Abramovitch -- Infection of human neutrophils to study virulence properties of mycobacterium tuberculosis / Tobias Dallenga, Björn Corleis, and Ulrich E. Schaible -- Isolation of bead phagosomes to study virulence function of M. tuberculosis cell wall lipids / Anna C. Geffken, Emmanuel C. Patin, and Ulrich E. Schaible -- Live imaging of mycobacterium marinum infection in dictyostelium discoideum / Caroline Barisch, Ana T. López-Jiménez, and Thierry Soldati -- Testing chemical and genetic modulators in mycobacterium tuberculosis infected cells using phenotypic assays / Vincent Delorme [and 3 others].
  • Digital/Print
  • Digital
    edited by Vassil St. Georgiev, Karl A. Western, John J. McGowan.
    Springerv. 1, 2008
    Springerv. 2, 2009
    Springerv. 3, 2010
    v. 1. Frontiers in research -- v. 2. Impact on Global Health -- v. 3. Intramural research.
  • Digital
    Eric Vivier, James Di Santo, Alessandro Moretta, editors.
    Springer2016
    Transcriptional control of NK cells -- Development, homeostasis, and heterogeneity of NK cells -- Diversification and functional specialization of human NK cell subsets -- Dynamic regulation of NK cell responsiveness -- NK cells and cancer immunoediting -- Sweet is the memory of past troubles: NK cells remember -- Lessons from NK cell definiencies in the mouse -- Probing human NK cell biology using human immune system (HIS) mice -- Haploidentical haematopoietic stem cell transplantation: role of NK cells and effect of cytomegalovirus infections -- The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer -- Index.
  • Digital
    edited by Kimberly McCall, Charles Klein.
    Springer Protocols2013
    Cell death is an essential process in development, and a major contributor to a wide range of human diseases. Three major classifications of cell death, apoptosis, autophagic cell death and necrosis, have been described for years, and the existence of many more forms of cell death is now accepted. In, Necrosis: Methods and Protocols experts in the field provide a wide range of methods and techniques for the study of necrosis in vitro and in vivo. These include methods and techniques for the analysis of necrosis in mammalian cells, characterization of alternative forms of cell death: entosis and pyroptosis, and analysis of cell death in non-mammalian model sytems and mammalian tissues, including chapters on skin, brain, and heart. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. -- Publisher website.
  • Digital
    [editors] Rafi Ahmed, Tasuku Honjo, Editors.
    Springer2011
    TIM-3 and its regulatory role in immune responses / Chen Zhu, Ana C. Anderson and Vijay K. Kuchroo -- Role of PD-1 in regulating T-cell immunity / Hyun-Tak Jin, Rafi Ahmed and Taku Okazaki -- The role of IL-10 in regulating immunity to persistent viral infections / Elizabeth B. Wilson and David G. Brooks -- Inhibitory Ly49 receptors on mouse natural killer cells / Mark T. Orr and Lewis L. Lanier -- Immunoregulatory roles for Fc receptor-like molecules / Götz R.A. Ehrhardt and Max D. Cooper -- Fc[gamma]Rs in health and disease / Falk Nimmerjahn and Jeffrey V. Ravetch -- TGF-[beta] function in immune suppression / Akihiko Yoshimura and Go Muto.
  • Digital
    Jose Antonio Gomez Aguilera.
    The outcomes of most viral infections are controlled by many genetic loci whose interactions are complex and difficult to predict. To characterize the genes that predispose to viral persistence, I carried out a genetic analysis of a murine susceptibility locus termed Tmevp3. Mice that carry the SJL/J-derived Tmevp3 locus become persistently infected, whereas mice carrying the B10.S-derived locus clear the infection. My investigation revealed that a long noncoding RNA, lncRNA, transcript named NeST RNA was the most polymorphic gene in the locus. I found that a spliced version of NeST RNA was abundant in T cells of SJL/J mice and not expressed in B10.S mice. To test whether expression of this lncRNA was the cause of viral persistence, I developed transgenic mice that expressed NeST RNA in B10.S mice. Indeed, NeST RNA alone was sufficient to confer viral persistence. To investigate the function of NeST RNA in T cells, I tested whether NeST regulates its neighboring genes, IL-22 and IFN-[gamma]. CD8+ T cells from mice carrying the SJL/J-Tmevp3 locus were found to produce greater amounts of IFN-[gamma], suggesting that NeST RNA might functions as an enhancer lncRNA. Indeed, transgenic expression of NeST lncRNA induced higher of IFN-[gamma] after T cell stimulation. Results from a collaborative study revealed NeST RNA functions in trans, localize to the nucleus, associates with the histone modifying complex component WDR5, and induces accumulation of histone 3 lysine 4 trimethylation (H3K4me3) at the Ifng locus. I also found that the Tmevp3 locus controls lethality from Salmonella. However, I found that in this model the SJL/J allele, which increases viral persistence, conferred decrease susceptibility for pathogenesis. As was the case in the viral susceptibility model, transgenic NeST RNA expression was sufficient to recapitulate this susceptibility phenotype. To test for any effects of NeST RNA in the inflammatory response to pathogen antigens, I carried out septic shock assays using the bacterial component LPS. I found that mice expressing NeST RNA survived more compared to the B10.S parental strain. Take together these data suggest that during immune challenge NeST RNA regulates the inflammatory response. To further analyze the effect of NeST RNA in the control of inflammation, NeST knockout mice were utilized. Deleting a 640 base pair region in the NeST promoter was found to abrogate gene expression and increase lethality to LPS sepsis. This difference in lethality coincided with larger abundances of numerous cytokines in mice lacking NeST RNA after LPS injections. However in the absence of an immune challenge, mice with an intact NeST gene showed higher basal levels of inflammatory cytokines, suggesting the basis of NeST RNA protection is a hormetic effect. Indeed, pre-treatment with low doses of LPS phenocopies the endotoxin tolerance effect of NeST RNA. Understanding how NeST RNA controls the timing and magnitude of cytokine secretion by T cells may provide new venues for therapeutic intervention to various inflammatory diseases.
  • Digital
    edited by W. Scott Champney.
    Springer Protocols2008
  • Digital
    edited by Michael Goodfellow, Iain Sutcliffe, Jongsik Chun.
    ScienceDirect2014
    Chapter 1. The Need for Change: Embracing the Genome / William B. Whitman -- Chapter 2. An Introduction to Phylogenetics and the Tree of Life / Tom A. Williams, Sarah E. Heaps -- Chapter 3. The All-Species Living Tree Project / Pablo Yarza, Raul Munoz -- Chapter 4. 16S rRNA Gene-Based Identification of Bacteria and Archaea using the EzTaxon Server / Mincheol Kim, Jongsik Chun -- Chapter 5. Revolutionizing Prokaryotic Systematics Through Next-Generation Sequencing / Vartul Sangal, Leena Nieminen, Nicholas P. Tucker, Paul A. Hoskisson -- Chapter 6. Whole-Genome Analyses: Average Nucleotide Identity / David R. Arahal -- Chapter 7. Whole-Genome Sequencing for Rapid and Accurate Identification of Bacterial Transmission Pathways / Simon R. Harris, Chinyere K. Okoro -- Chapter 8. Identification of Conserved Indels that are Useful for Classification and Evolutionary Studies / Radhey S. Gupta -- Chapter 9. Reconciliation Approaches to Determining HGT, Duplications, and Losses in Gene Trees / Olga K. Kamneva, Naomi L. Ward -- Chapter 10. Multi-Locus Sequence Typing and the Gene-by-Gene Approach to Bacterial Classification and Analysis of Population Variation / Alison J. Cody, Julia S. Bennett, Martin C.J. Maiden -- Chapter 11. Multi-locus Sequence Analysis: Taking Prokaryotic Systematics to the Next Level / Xiaoying Rong, Ying Huang -- Chapter 12. Bacterial Typing and Identification By Genomic Analysis of 16S-23S rRNA Intergenic Transcribed Spacer (ITS) Sequences / Volker Gürtler, Gangavarapu Subrahmanyam, Malathi Shekar, Biswajit Maiti, Indrani Karunasagar -- Chapter 13. MALDI-TOF Mass Spectrometry Applied to Classification and Identification of Bacteria / Peter Schumann, Thomas Maier -- Chapter 14. Continuing Importance of the “Phenotype” in the Genomic Era / Peter Kämpfer -- Index.

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MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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