Books by Subject
- AccessMedicine Lange Case files — Fungal biofilms and related infections : advances in microbiology, infectious diseases and public health. Volume 3 (100)
- Fungal diagnostics : methods and protocols — Molecular and cellular mechanisms of antibody activity (100)
- Molecular cellular microbiology — Toxoplasma gondii co-opts host immune signaling by secretion of a polymorphic tyrosine kinase, ROP16 (100)
- TT viruses : the still elusive human pathogens — Yeast systems biology : methods and protocols (18)
- 2013 Springer Protocolsedited by Louise O'Connor and Barry Glynn.Overview of invasive fungal infections / Nina L. Tuite and Katrina Lacey -- Fungal diagnostics : review of commercially available methods / Javier Yugueros Marcos and David H. Pincus -- Rapid methods for the extraction and archiving of molecular grade fungal genomic DNA / Andrew M. Borman, Michael Palmer, and Elizabeth M. Johnson -- APEX DNA microarray for the identification of pathogenic fungi / Arianna Tavanti, Stefano Landi, and Sonia Senesi -- Microscopic detection of yeasts using fluorescence in situ hybridization / João Inácio and Maria da Luz Martins -- Quantitative detection of Aspergillus spp. by real-time nucleic acid sequence-based amplification / Yanan Zhao and David S. Perlin -- Differentiation of fungi using hybridization probes on the LightCycler® / Stephan Fricke [and others] -- Quantitative and multiplex detection of pathogenic fungi using padlock probes, generic qPCR, and suspension array readout / Magnus Jobs, Ronnie Eriksson, and Jonas Blomberg -- Species-specific identification of a wide range of clinically relevant fungal pathogens by the Luminex® xMAP technology / S. Preuner and T. Lion -- Applied gene histopathology : identification of Fusarium species in FFPE tissue sections by in situ hybridization / Yoichiro Okubo [and others] -- Application of chip-based flow cytometry for amphotericin B and fluconazole susceptibility testing on Candida strains / Orsolya Bouquet [and others] -- Surface plasmon resonance genosensor for the detection of Fusarium culmorum / Michelangelo Pascale, Francesco Zezza, and Giancarlo Perrone -- Hyperbranching rolling circle amplification, an improved protocol for discriminating between closely related fungal species / Jiufeng Sun and Sybren de Hoog -- Loop-mediated isothermal amplification-based detection of Fusarium graminearum / Ludwig Niessen -- Multiplex-tandem PCR for fungal diagnostics / Anna Lau, Keith Stanley, and Tania Sorrell -- Specific detection of Pneumocystis jirovecii in clinical samples by flow cytometry / Joana Barbosa [and others].
- 2006 Springeredited by A.J. Brown, K. Esser.
- 2012 Springer Protocolsedited by Nancy P. Keller, Geoffrey Turner.Library preparation and data analysis packages for rapid genome sequencing -- Bioinformatics approaches and software for detection of secondary metabolic gene clusters -- Media and growth conditions for induction of secondary metabolite production -- Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays -- The "FERMEX" Method for metabolite-enriched fungal extracts -- The chemical identification and analysis of aspergillus nidulans secondary metabolites -- Detection and purification of non-ribosomal peptide synthetase products in Neosartorya fischeri -- Production, detection, and purification of clavine-type ergot alkaloids -- Analysis of volatile compounds emitted by filamentous fungi using solid-phase microextraction-gas chromatography/mass spectrometry -- Tools for manipulation of secondary metabolism pathways: Rapid promoter replacements and gene deletions in Aspergillus nidulans -- Fast and easy method for construction of plasmid vectors using modified quick-change mutagenesis -- Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal host -- Multi-copy genetic screen in Aspergillus nidulans -- Identification of protein complexes from filamentous fungi with tandem affinity purification -- Correlating secondary metabolite production with genetic changes using differential analysis of 2d NMR spectra -- Chromatin immunoprecipitation analysis in filamentous fungi -- Targeted proteomics for metabolic pathway optimization -- Investigation of in vivo protein interactions in Aspergillus spores -- Purification of a vesicle-vacuole (v) fraction from Aspergillus -- Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi -- Molecular analysis of fungal gene expression upon interkingdom competition with insects.
- 2016 Springer Protocolsedited by Jeffrey L. Bose.Understanding staphylococcal nomenclature / Christina N. Krute and Jeffrey L. Bose -- Restriction-modification systems as a barrier for genetic manipulation of Staphylococcus aureus / Marat R. Sadykov -- Complementation plasmids, inducible gene-expression systems, and reporters for Staphylococci / Ralph Bertram -- De novo assembly of plasmids using yeast recombinational cloning / Ameya A. Mashruwala and Jeffrey M. Boyd -- Splicing by overlap extension PCR to obtain hybrid DNA products / Justin A. Thornton -- Method for preparation and electroporation of S. aureus and S. epidermidis / Melinda R. Grosser and Anthony R. Richardson -- Rapid isolation of DNA from staphylococcus / Kelsey L. Krausz and Jeffrey L. Bose -- Bacteriophage transduction in Staphylococcus aureus : broth-based method / Kelsey L. Krausz and Jeffrey L. Bose -- Bacteriophage transduction in Staphylococcus aureus / Michael E. Olson -- Batch transduction of transposon mutant libraries for rapid phenotype screening in staphylococcus / Katherine L. Maliszewski -- Conjugative transfer in Staphylococcus aureus / Cortney R. Halsey and Paul D. Fey -- Allelic exchange / McKenzie K. Lehman, Jeffrey L. Bose, and Kenneth W. Bayles -- Creation of staphylococcal mutant libraries using transposon Tn917 / Kelly C. Rice -- Generation of a transposon mutant library in Staphylococcus aureus and staphylococcus epidermidis using bursa aurealis / Vijaya Kumar Yajjala ... [et al.] -- Chemical and UV mutagenesis / Jeffrey L. Bose -- Pulse field gel electrophoresis / Batu K. Sharma-Kuinkel, Thomas H. Rude, and Vance G. Fowler Jr. -- RNA-sequencing of Staphylococcus aureus messenger RNA / Ronan K. Carroll, Andy Weiss, and Lindsey N. Shaw -- Quantitative real-time PCR (qPCR) workflow for analyzing Staphylococcus aureus gene expression / April M. Lewis and Kelly C. Rice -- Electrophoretic mobility shiftaAssays / Sarah E. Rowe and James P. O'Gara -- Rapid amplification of cDNA ends for RNA transcript sequencing in staphylococcus / Eric Miller.
- 2013 SpringerSheela Srivastava.Described as the earliest, simplest life forms, with unlimited metabolic versatility, bacteria are ideally suited to answer some very fundamental questions on life and its processes. They have been employed in almost all fields of biological studies, including Genetics. The whole edifice of science of Genetics centers around three processes: the generation, expression, and transmission of biological variation, and bacteria offer immediate advantages in studying all the three aspects of heredity. Being haploid and structurally simple, it becomes easy to isolate mutations of various kinds and relate them to a function. The availability of such mutants and their detailed genetic and biochemical analyses lead to a gamut of information on gene expression and its regulation. While studying the transmission of biological variation, it is clear that unlike their eukaryotic counterpart, a more genetic approach needs to be employed. Transmission of genetic information in most eukaryotic organisms rests on sexual reproduction that allows the generation of genetically variable offspring through the process of gene recombination. Even though bacteria show an apparent preference for asexual reproduction, they too have evolved mechanisms to trade their genetic material. In fact, bacteria not only could acquire many genes from close relatives, but also from entirely distant members through the process of horizontal gene transfer. Their success story of long evolutionary existence will stand testimony to these mechanisms. While teaching a course on Microbial Genetics to the post-graduate students at Delhi University, it was realized that a book devoted to bacterial genetics may be very handy to the students, researchers, and teachers alike. A strong foundation in genetics also helps in comprehending more modern concepts of molecular biology and recombinant DNA technology, always a favorite with the students and researchers. Planning the format of the book, emphasis has been laid on the generation and transmission of biological variability. The omission of expression part is indeed intentional because lots of information is available on this aspect in any modern biology book. The contents are spread over seven chapters and the text is supported with figures/tables wherever possible. The endeavor has been to induce the readers to appreciate the strength of bacterial genetics and realize the contribution of these tiny organisms to the growth of biological sciences as a whole and genetics in particular.
- 2007 Springeredited by Robert D. Perry and Jacqueline D. Fetherston."The 9th International Symposium on Yersinia was held in Lexington, Kentucky, USA on October 10-14, 2006. Over 250 Yersinia researchers from 18 countries gathered to present and discuss their research. In addition to 37 oral presentations, there were 150 poster presentations. This Symposium volume is based on selected presentations from the meeting and contains both reviews and research articles. It is divided into six topic areas: 1) genomics; 2) structure and metabolism; 3) regulatory mechanisms; 4) pathogenesis and host interactions; 5) molecular epidemiology and detection; and 6) vaccine and antimicrobial therapy development. Consequently, this volume covers a wide range of current research areas in the Yersinia field."--Preface.Also available: Print – 2007
- 2008 Springeredited by Gary B. Huffnagle, Mairi Noverr.Overview of gut immunology / Katie Lynn Mason ... [et al.] -- The commensal microbiology of the gastrointestinal tract / Janet M. Manson, Marcus Rauch and Michael S. Gilmore -- Overview of the gastrointestinal microbiota / -- Vincent B. Young and Thomas M. Schmidt -- Effects of microbiota on GI health : -- Gnotobiotic research / Robert Doug Wagner -- Positive interactions with the microbiota : probiotics / Marko Kalliomøki, Seppo Salminen and Erika Isolauri -- Negative interactions with the microbiota : IBD / Nita H. Salzman and Charles L. Bevins -- Diet, immunity, and functional foods / Lesley Hoyles and Jelena Vulevic -- Host : microbe communication within the GI tract / Christopher A. Allen and Alfredo G. Torres -- Host : microbe symbiosis : the squid, vibrio association : a naturally occurring, experimental model of animal/bacterial partnerships / Margaret McFall-Ngai -- The "microflora hypothesis" of allergic disease / Andrew Shreiner, Gary B. Huffnagle and Mairi C. Noverr -- The damage : response framework of microbial pathogenesis and infectious diseases / Liise-anne Pirofski and Arturo Casadevall.Also available: Print – 2008
- 2006 Springervolume editors, U. Kües, R. Fischer.
- 2006 CRCnetBASEedited by Stephen P. Denyer, Rosamund M. Baird.
- 2008 CRCnetBASETibor Deak.
- 2014 CRCnetBASERonald M. Atlas, James W. Snyder."Preface Almost 1,800 media are described in the Handbook of Media for Clinical and Public Health Microbiology, including newly described media for the cultivation of emerging pathogens. Diseases caused by emerging pathogens that are responsible for increased rates of morbidity and mortality rates, such as Escherichia coli O157:H7, methicillin resistant Staphylococcus aureus (MRSA), vancomycin resistant enterococci (VRE), and carbapenem resistant enterococci (CRE) have raised special concerns and various media included in the Handbook have been designed for the specific cultivation and identification of these pathogens. Many of the new media included in the Handbook of Media for Clinical and Public Health Microbiology permit the cultivation of bacteria, fungi, and viruses that are currently causing major medical problems around the world. These media are very important for the rapid detection of pathogenic microorganisms and the diagnosis of individuals with specific infectious diseases adn for preventing the spread of pathogens via food, water, and environmental sources. Several of the new media described in the Handbook of Media for Clinical and Public Health Microbiology include chromogenic or fluorogenic substrates that permit the rapid detection of specific pathogens. An important function of the Handbook of Media for Clinical and Public Health Microbiology is to provide descriptions of the media that are used to cultivate and identify microorganisms from clinical specimens and those of public health significance. The Handbook provides a compilation of the formulations, methods of preparation, and applications for media used in clinical and public health microbiology laboratories"--Provided by publisher.
- 2008 CRCnetBASEedited by Glenn R. Gibson, Marcel Roberfroid.Endocrinology of the gastro-intestinal tract and modulation of satiety: specific focus on glucagon like peptide-1 / R. Burcelin & P.D. Cani -- Prebiotics and modulation of gastrointestinal peptides / P.D. Cani, R. Burcelin & C. Knauf -- Designing studies and rodent models for studying prebiotics for colorectal cancer prevention / N.J. Emenaker & J.A. Milner -- Colorectal cancer prevention: the role of prebiotics / A. Umar, N.J. Emenaker & J.A. Milner -- Prebiotics and reduction of risk of carcinogenesis: review of experimental and human data / A. Klinder, M. Glei & B.L. Pool-Zobel -- Prebiotics and cancer therapy / H.S. Taper & M.B. Roberfroid -- Pathophysiology of inflammatory bowel diseases / F.Hoentjen & L. A. Dieleman -- Prebiotics in inflammatory bowel diseases / F. Guarner -- Prebiotics and infant nutrition / Y. Vandenplas ... [et al.] -- Prebiotics and nutrition in the elderly: the concept of healthy aging / I.R. Rowland & C. Gill -- Prebiotics and animal nutrition / J. Van Loo -- Food applications of prebiotics / A. Franck -- Prebiotics and food safety / G. Pascal -- Concluding remarks / G.R Gibson & M.B. Roberfroid. General introduction: prebiotics in nutrition / M.B Roberfroid -- Gastrointestinal microflora and interactions with gut mucosa / A.L. Wells, D.M.A. Saulnier, and G.R. Gibson -- Prebiotics: concept: definition, criteria, methodologies, and products / M.B. Roberfroid -- The prebiotic effect: review of experimental and human data / S. Kolida and G.R.Gibson -- Effects of prebiotics on mineral absorption: mechanisms of action / I.J. Griffin & S.A. Abrams -- Prebiotics and the absorption of minerals, a review of experimental and human data / K.M. Hawthorne & S.A. Abrams -- Immune functions and mechanisms in the gastrointestinal tract / A. Dubert-Ferrandon, D.S. Newburg & W.A. Walker -- Prebiotics and the immune system: review of experimental and human data / S. Seifert & B. Watzl -- Triacylglycerols and cholesterol metabolism / M.Beylot, F. Forcheron & D. Letexier -- Prebiotics and lipid metabolism: review of experimental and human data / N.M. Delzenne & A.M. Neyrinck --
- 2015 CRCnetBASEedited by William Olds.Part 1. Introduction : the rainforest in the gut -- part 2. Microbiome's role in obesity -- part 3. Inflammation and innate immunity -- part 4. Nutrition's effect on the microbiome -- part 5. Using the microbiome to identify and cure disease.
- Helicobacter pylori : molecular mechanisms for the utilization of the cell surface as a replicative niche2010Shumin Tan.Helicobacter pylori is a bacterium that chronically infects the stomachs of more than half the human population, in some cases leading to serious diseases such as gastric cancer and ulcers. H. pylori intimately interact with the gastric epithelial surface, but much remains unknown about its life on the cell surface. The bacterium possesses several tools for its close interaction with the gastric epithelia, including a type IV secretion system, through which the virulence factor CagA is directly translocated into host cells. This dissertation focuses on how H. pylori's close interactions with the epithelial cells allows it to modify the apical cell surface to turn it into a replicative niche for the bacterium. Using live-cell microscopy to follow the fate of individual bacteria on the cell surface, we find that H. pylori is able to utilize the apical cell surface as a replicative niche, even in conditions that do not support the growth of free-swimming bacteria. Experiments with a polarized epithelial model system show that the bacterium's major virulence factors CagA and VacA both play important roles in enabling H. pylori growth and microcolony formation on the apical cell surface, by mediating perturbation of host cell polarity and intracellular trafficking processes. We find that iron is one important micronutrient that H. pylori acquires from host cells during colonization of the polarized epithelium. CagA and VacA act in concert to affect the polarized process of transferrin/transferrin receptor recycling and iron uptake in the host cells, resulting in the mis-sorting of a subset of the transferrin/transferrin receptor complex to the colonizing bacteria on the apical cell surface. This process is functionally important for the bacteria, as downregulation of transferrin receptor expression resulted in a decreased ability of H. pylori to colonize the polarized epithelium. These studies establish the cell surface as a replicative niche, which presents challenges that require bacterial adaptation for its successful utilization. Our findings also illustrate the concept that contact-dependent bacterial virulence factors may be used for the perturbation of host cell physiology for the bacterium's benefit, allowing acquisition of needed factors directly from host cells, and colonization of the apical cell surface.
- 2012 Springer Protocolsedited by JeanMarie Houghton.Introduction / JeanMarie Houghton -- Helicobacter pylori: an overview / Jennifer M. Noto, Richard M. Peek -- Perspectives on methodology for in vitro culture of Helicobacter pylori / Timothy L. Cover -- Successful culture techniques for Helicobacter species : general culture techniques for Helicobacter pylori / Jeannette M. Whitmire, D. Scott Merrell -- Successful culture techniques for Helicobacter species: establishing H. pylori cultures from infected rodents / Jeannette M. Whitmire, D. Scott Merrell -- Successful culture techniques for Helicobacter species: verification of Helicobacter identity using 16s rRNA gene sequence analysis / Jeannette M. Whitmire, D. Scott Merrell -- The Helicobacter pylori cag pathogenicity island / Jennifer M. Noto, Richard M. Peek -- Genetic manipulation of a naturally competent bacterium, Helicobacter pylori / Jennifer M. Noto, Richard M. Peek -- A method for short-term culture of human gastric epithelial cells to study the effects of Helicobacter pylori / Marina Leite, Ceu Figueiredo -- Cell culture-based assays to test for bacterial adherence and internalization / Deepa Raju, David Rizzuti, Nicola L. Jones -- Cell culture assays to evaluate bacterial toxicity and virulence / Deepa Raju, David Rizzuti, Nicola L. Jones -- Rodent models of Helicobacter infection, inflammation and disease / Songhua Zhang, Steven F. Moss -- Bacterial culture and inoculation of mice (simple infection) / Brian M. Gray, Kathryn A. Eaton -- Adoptive transfer of splenocytes to immunocompromised mice / Brian M. Gray, Kathryn A. Eaton -- Isolation of gastric lamina propria leukocytes / Brian M. Gray, Kathryn A. Eaton -- Delayed-type hypersensitivity determination / Brian M. Gray, Kathryn A. Eaton -- Necropsy, blood, tissue collection and mRNA isolation for detection of host cytokine gene expression / Brian M. Gray, Kathryn A. Eaton -- Animal models of Helicobacter-induced disease: methods to successfully infect the mouse / Nancy S. Taylor, James G. Fox -- Verifying and quantifying Helicobacter pylori infection status of research mice / Mark T Whary, Zhongming Ge, James G. Fox -- Mouse models of Helicobacter-induced gastric cancer: use of cocarcinognes / Richard L. Ferrero, John E. Wilson, Phil Sutton -- Gastric Helicobacter spp. in animal models: pathogenesis and modulation by extragastric coinfections / Arlin B. Rogers -- Histologic scoring of gastritis and gastric cancer in mouse models / Arlin B. Rogers -- Innate immune responses to Helicobacter pylori infection: an overview / Milan K. Patel, Melanie I. Trombly, Evelyn A. Kurt-Jones -- Methods for in vivo and in vitro analysis of innate immune responses to Helicobacter pylori infection / Milan K. Patel [and others] -- Techniques for following labeled cells in vivo: use of X/Y FISH, techniques to optimize fluorescent detection, and beta-galactosidase detection / Michael Craig, Michael Schumacher, Yana Zavros -- In vivo measurement of Helicobacter pylori infection / Marjan Mohammadi [and others].
- 2012 SpringerBenhur Lee, Paul A. Rota, editors.Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K. T. Wong and C. T. Tan -- Henipaviruses in Their Natural Animal Hosts / D. J. Middleton and H. M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
- 2013 Springeredited by Ralf Bartenschlager.Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
- 2013 SpringerMoshe Oren, Yael Aylon, editors.The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.
- 2016 SpringerThomas J. Inzana, editor.Taxonomy of Histophilus somni -- Histophilosis as a Natural Disease -- Histophilus somni Genomics and Genetics -- Interactions on Histophilus somni with Host Cells -- Histophilus somni Surface Proteins -- Host Immune Response to Histophilus somni -- The Many Facets of Lipooligosaccharide as a Virulence Factor of Histophilus somni -- Exopolysaccharide Production and Biofilm Formation by Histophilus somni.
- 2012Josephine Y. Lee.Helicobacter pylori is a human specific pathogen that chronically infects the stomachs of over half of the world's population. Infection with H. pylori strains expressing the virulence factor, CagA, greatly increases the risk of developing gastric cancer, although only a subset of infected individuals develop severe disease. It is therefore important to define factors that contribute to disease progression in the context of H. pylori infection. This body of work began with developing a CagA+ mouse model in which both H. pylori and mouse genetics can be used to study disease development. Using this system, we have identified three novel factors that influence disease progression. Two months after oral infection, mice develop precancerous lesions such as mucous metaplasia. However, animals infected as neonates are protected from developing lesions compared to mice infected as adults, suggesting that the age of infection is an important risk factor for disease development. Using 3D confocal microscopy, we discovered that H. pylori preferentially colonizes gastric glands in the antrum of the stomach. A chemotaxis mutant that is unable to properly sense and respond to its environment can colonize the surface of the stomach but fails to colonize the mid-gastric glands. Development of pathology is reduced in animals infected with the chemotaxis mutant, indicating that bacterial factors that affect localization of H. pylori within the glands is important for disease progression. Surprisingly, we discovered that the severity of pathology in genetically identical C57BL/6 mice from two different vendors is dramatically different. Mice from one vendor develop an antrum-dominant infection and inflammation, but fail to develop precancerous lesions. Mice from the second vendor develop precancerous lesions, and the infection and inflammatory response are distributed throughout the stomach. Our findings align with disease progression observed in human infection with H. pylori, in which an antrum-dominant gastritis is protective against cancerous lesions and pan-gastritis is associated with gastric cancer development. We suspected that the gut microbiota is an environmental factor that influences differences in H. pylori localization and host pathology. By co-housing animals from the two vendors or perturbing the flora with antibiotics prior to infection with H. pylori, we found that both bacterial localization and pathology could be shifted to the corpus in the animals from the first vendor, suggesting that the microbiota may influence H. pylori localization and disease progression. Since mice from second vendor had a dominant phenotype in the co-housing experiments, we compared the gut microbiota composition of the animals by sequencing fecal samples obtained before and after co-housing. The microbiota of the animals from the two vendors were different prior to co-housing, but after co-housing, the microbiota of both groups was similar to the animals from the second vendor. These findings support the observation that mice from the first vendor phenocopy mice from the second vendor after co-housing. We are currently identifying specific components of the microbiota that may be responsible for shifting the phenotype. Analysis of differences in the immune response of animals from the two vendors suggest that the microbiota may shift the immune balance in response to H. pylori infection and lead to differential disease outcomes. Using our mouse model of infection, we have identified novel host, bacterial and environmental factors that contribute to H. pylori-induced disease progression.
- 2012 Springer Protocolsedited by Alexandra C. Brand, Donna M. MacCallum.Gene deletion in Candida albicans wild-type strains using the SAT1-flipping strategy -- Mini-blaster-mediated targeted gene disruption and marker complementation in Candida albicans -- Rapid detection of aneuploidy following the generation of mutants in Candida albicans -- Agrobacterium-mediated insertional mutagenesis in histoplasma capsulatum -- Targeted gene disruption in cryptococcus neoformans using double-joint PCR with split dominant selectable markers -- Multiple gene deletion in cryptococcus neoformans using the cre-lox system -- Gene disruption in aspergillus fumigatus using a PCR-based strategy and in vivo recombination in yeast -- Targeted gene deletion in aspergillus fumigatus using the hygromycin-resistance split-marker approach -- Gene disruption in coccidioides using hygromycin or phleomycin resistance markers -- RNAi-based gene silencing using a GFP sentinel system in histoplasma capsulatum -- RNA interference in cryptococcus neoformans -- Gene knockdown in paracoccidioides brasiliensis using antisense RNA -- Tetracycline-inducible gene expression in Candida albicans -- Galactose-inducible promoters in cryptococcus neoformans var. Grubii -- Modular gene over-expression strategies for Candida albicans -- Interactions between macrophages and cell wall oligosaccharides of Candida albicans -- Murine bone marrow-derived dendritic cells and t-cell activation by Candida albicans -- Phagocytosis and intracellular killing of Candida albicans by murine polymorphonuclear neutrophils -- Human oral keratinocytes: A model system to analyze host-pathogen interactions -- Simple assays for measuring innate interactions with fungi -- Binding and uptake of Candida albicans by human monocyte-derived dendritic cells -- Immune responses to Candida albicans in models of in vitro reconstituted human oral epithelium -- Analysis of host-cell responses by immunoblotting, ELISA, and real-time PCR -- In vitro model of invasive pulmonary aspergillosis in the human alveolus -- Biofilm formation studies in microtiter plate format -- Transcript profiling using ESTs from Paracoccidioides brasiliensis in models of infection -- Laser capture microdissection of Candida albicans from host tissue -- Isolation and amplification of fungal RNA for microarray analysis from host samples -- Cytokine measurement using cytometric bead arrays -- Transcript profiling of the murine immune response to invasive aspergillosis -- Caenorhabditis elegans: A nematode infection model for pathogenic fungi -- Drosophila melanogaster as a model organism for invasive aspergillosis -- Galleria mellonella as a model for fungal pathogenicity testing -- Embryonated chicken eggs as alternative infection model for pathogenic fungi -- Mouse intravenous challenge models and applications -- A nebulized intra-tracheal rat model of invasive pulmonary aspergillosis -- Invasive models of histoplasmosis -- Murine model of concurrent oral and vaginal Candida albicans colonisation -- A luciferase reporter for gene expression studies and dynamic imaging of superficial Candida albicans infections -- Modeling of fungal biofilms using a rat central vein catheter -- Orogastrointestinal model of mucosal and disseminated candidiasis -- A nonlethal murine cutaneous model of invasive aspergillosis.
- 2013Smita Gopinath.Host-adapted pathogens depend on their host for transmission and dissemination to new hosts. Salmonella enterica includes a plethora of serovars that cause host-adapted diseases in both livestock animals and humans, an example of which is Salmonella enterica serovar Typhi, the causative agent of typhoid fever. Epidemiological and mathematical modeling data indicate that a specific subset of infected hosts are responsible for the majority of disease transmission. Human typhoid carriers are a classic example of this subset, characterized by persistently infected yet asymptomatic individuals who transmit disease via the fecal oral route. The work contained in this thesis attempts to answer how carriers differ from other hosts, in particular how the host immune response in carriers allows those individuals to remain asymptomatic despite the large numbers of Salmonella in the gastrointestinal tract. We use a mouse model of persistent Salmonella infection wherein a subset of the infected hosts (super-shedders) are able to transmit disease to naive cage mates. Having characterized the development of the host immune response during chronic Salmonella infection, we identify an immune state unique to super-shedder hosts. The super-shedder immune phenotype consists of an active innate immune response with high frequency of neutrophils and serum Interleukin-6 and a suppressed adaptive T cell response with dampened cytokine responsiveness. Administration of Granulocyte colony stimulating factor to moderate-shedders is sufficient to phenocopy the blunted T cell responses of the super-shedder immune state demonstrating that neutrophils control the suppression of the adaptive T cell response. The super-shedder immune state also serves a functional purpose, protecting the host against antibiotic-driven dysbiosis. The microbiota and host-pathogen interactions together induce a unique state of tolerance in Salmonella carriers, potentially contributing to the transmission of the pathogen in the general population.
- 2010Andrew Hotson.The immune response to a pathogen is a complex interplay between host factors aimed to eradicate the pathogen, and microbe virulence proteins designed to subvert the host. To successfully combat a pathogen, the host must identify the insult and activate an immune response tailored to eliminate the specific microbe. This entails cell signaling at the level of innate immunity to detect the pathogen and mount an immediate non-specific response, while also communicating to bystander cells to shape the scope of the adaptive arm of immunity. The work herein investigates how the intracellular signaling network is activated and perturbed across cell types and hematopoietic tissues during bacterial infection. An introductory background on the current knowledge in the field of immune signaling is provided in chapter 1. Antigen presenting cells detect pathogenic motifs via pattern recognition receptors including toll-like receptors. This triggers an intracellular signaling cascade with specific transcriptional consequences, including the production of cytokines. In turn, these cytokines alert additional cell types to activate specific signal transducer and activator of transcription (STAT) transcription factor family members. Thus, detection of a microbe initiates rapid signaling across leukocytes to set the stage for the immune response. Chapter 2 focuses on cell signaling experiments in a murine model for the onset of sepsis. Mice were acutely challenged with avirulent E. coli and Listeria monocytogenes to study the host response without pathogenic manipulation of host signaling by bacterial virulence factors. Bacterial challenge causes macrophages and dendritic cells to become attenuated in their ability to respond to TLR agonists, a hallmark of endotoxin tolerance. Also, it induces global dampening of the STAT response to cytokines across all cell types; splenocytes from challenged mice poorly respond to cytokine stimulation. Cytokines secreted by antigen presenting cells act on bystander cells and induced negative feedback, including SOCS expression and receptor endocytosis that prevent further STAT activation. Thus, bacterial recognition causes host immune activation followed by subsequent suppression of signaling. The work in chapter 3 transitions to a model of chronic infection with pathogenic Salmonella typhimurium. In addition to examining the innate response, this model enables investigation of adaptive immunity by monitoring the activation of T cells, their cytokine response profile, and TH-biasing by the transcription factors they express and cytokines they produce. During chronic infection, B cells and effector T cells undergo expansion but not contraction over the first 30 days, demonstrating that the immune system establishes a new equilibrium. However, the degree of cell expansion, as well as the ability of these cells to respond to cytokine, is quite variable across mice. These mice also have varied levels of bacterial burden, and the shape of the immune response denotes disease severity. High bacterial load is associated with trademarks of innate immunity such as elevated neutrophil numbers, serum cytokine levels, and the dampened STAT signaling observed during bacterial challenge in chapter 2. In contrast, the mice that control infection are enriched for markers of adaptive T cell immunity: high numbers of TH1 effector T cells, T cell proliferation, ability to respond to cytokines, and fewer regulatory T cells. Therefore, a strong adaptive response is correlated with containing the infection, while an innate response is indicative of high bacterial levels. This thesis concludes in chapter 4, with a discussion of how the findings fit in the context of cell signaling in other disease states. Leukemia and lymphomas, diseases of uncontained cell growth, are characterized by hyperactive cell signaling. In contrast, an activated immune response, such as during auto-immunity or in cancer infiltrating T cells, is marked by repressed ability to respond to cytokines. As inhibited cytokine responses were also observed during bacterial challenge and during severe chronic infection, it appears that a commonality amongst disease that activate an immune response is negative feedback to dampen further signaling and restrict inflammation.
- 2008 Springer Protocolsedited by Steffen Rupp and Kai Sohn.
- 2013 SpringerG. Singh Chhatwal, editor.Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
- 2003 Kargervolume editor, Heiko Herwald.Also available: Print – 2003
- 2016 SpringerMarc Stadler, Petra Dersch, editors.This volume focuses on antibiotics research, a field of topical significance for human health due to the worrying increase of nosocomial infections caused by multi-resistant bacteria. It covers several basic aspects, such as the evolution of antibiotic resistance and the influence of antibiotics on the gut microbiota, and addresses the search for novel pathogenicity blockers as well as historical aspects of antibiotics. Further topics include applied aspects, such as drug discovery based on biodiversity and genome mining, optimization of lead structures by medicinal chemistry, total synthesis and drug delivery technologies. Moreover, the development of vaccines as a valid alternative therapeutic approach is outlined, while the importance of epidemiological studies on important bacterial pathogens, the problems arising from the excessive use of antibiotics in animal breeding, and the development of innovative technologies for diagnosing the "bad bugs" are discussed in detail. Accordingly, the book will appeal to researchers and clinicians alike.
- 2013Anna Poukchanski.Toxoplasma gondii is an obligate intracellular parasite. It has extraordinary abilities to infect virtually any warm blooded animal, cross a number of biological barriers (intestine, placenta and blood-brain), and invade any nucleated cell tested thus far in vitro. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to invade the host cell. Emphasis is placed on biological barriers and molecular mechanism of invasion for the different forms of the parasite. Chapter 2 describes a study of how Toxoplasma crosses the human placenta. Chapter 3 provides an insight as to how Enteric Glial Cells contribute to oral Toxoplasma infection in vivo. Chapter 4 deals with the study of how Toxoplasma sporozoites invade host cells. All research topics shed light on details of how Toxoplasma crosses the anatomical barriers: from the tissue barriers of placenta to infection to the possible immune and barrier functions of Enteric Glial Cells to how Toxoplasma sporozoites invade host cells. Chapter 2 describes experiments demonstrating that Toxoplasma tachyzoites invade the human placenta. These experiments used the human placental explant system to determine where the tachyzoites first invade, how they travel down the anchoring villi, and whether there exist type differences in ability to invade this tissue. This study provided several insights: (i) Toxoplasma tachyzoites are unable to penetrate the syncytium, and invade only the exposed tissue (anchoring villi); (ii) There does not appear to be a significant difference in the ability of different strains to infect the tissue. Chapter 3 addresses the possible role of TGF-[beta] by Enteric Glial Cells (EGCs) in oral Toxoplasma infection. Mice expressing a Dominant Negative TGF-[beta] receptor in EGCs were orally infected with Toxoplasma tissue cysts. At the end of the time trials, mice were sacrificed and their intestines subjected to histological analysis. Experiments did not reveal a clear-cut contribution to the control of inflammation by this cell type to the progress of disease. Chapter 4 examines the function of two paralogues of AMA1 and RON2 that are present exclusively in Toxoplasma sporozoites. Dubbed sporoAMA1 and sporoRON2, respectively, that sporoRON2 and sporoAMA1 form an exclusive pairing, stabilized with unique structural features. Furthermore, pre-treating sporozoites with a C-terminal portion of sporoRON2 (but not generic RON2) inhibits sporozoite invasion. We see sporoRON2 in a different compartment from RON4, suggesting that sporoRON2 functions independently of known moving junction components. These data indicate that sporozoites' host cell invasion is dependent on a novel, stage-specific version of the AMA1-RON2 pairing.
- 2008 Springervolume editor, Axel A. Brakhage, Peter F. Zipfel.
- 2015 SpringerJuan J. Lafaille, Maria A. Curotto de Lafaille, editors.Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
- 2010 ScienceDirectedited by Dieter Kabelitz and Stefan H.E. Kaufmann.1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
- 2013 SpringerLaura Santambrogio, editor.Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
- 2006 Kargervolume editors, Thomas Dittmar, Kurt S. Zaenker, Axel Schmidt.In remembrance of Rudolf Virchow (1821-1902) / Schmidt, A. -- In memoriam of Rudolf Virchow: a historical retrospective including aspects of inflammation, infection and neoplasia / Schmidt, A., Weber, O.F. -- Aneuploidy and cancer: from correlation to causation / Duesberg, P. ... [et al.] -- Adult stem cell theory of the multi-stage, multi-mechanism theory of carcinogenesis: role of inflammation on the promotion of initiated stem cells / Trosko, J.E., Tai, M.-H. -- Helicobacter pylori and gastric neoplasia / Leung, W.K. -- Schistosomiasis and neoplasia / Yosry, A. -- Relevant oncogenic viruses in veterinary medicine: original pathogens and animal models for human disease / Truyen, U., L"chelt, M. -- The inflammatory tumor microenvironment and its impact on cancer development / de Visser, K.E., Coussens, L.M. -- Co-opting macrophage traits in cancer progression: a consequence of tumor cell fusion? / Pawelek, J. ... [et al.] -- Carcinogenesis driven by bone marrow-derived stem cells / Dittmar, T. ... [et al.] -- Chemokine-directed metastasis / Gomperts, B.N., Strieter, R.M. -- Involvement of chemokine receptors in organ-specific metastasis / Zlotnik, A. -- Visualization of tumor cell extravasation / Heyder, C. ... [et al.] -- Options for visualizing metastatic disease in the living body / Helms, M.W., Brandt, B.H., Contag, C. -- Infection, inflammation and neoplasia: an interdisciplinary challenge / Zaenker, K.S.Also available: Print – 2006
- 2013 SpringerAnton G. Kutikhin, Arseniy E. Yuzhalin, Elena B. Brusina.The Criteria of Inclusion of Infectious Agents in the List of Biological Carcinogens -- General Mechanisms of Biological Carcinogenesis -- The Role of Bacteria in Cancer Development -- The Role of Protozoa in Cancer Development -- The Role of Helminthes and Fungi in Cancer Development -- Organ Microbiota in Cancer Development: The Holy Grail of Biological Carcinogenesis -- Conclusions: Are We There Yet?
- 2016 Springeredited by Steffen Backert, editor.This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future.
- 2014 SpringerRichard W. Compans, Michael B.A. Oldstone, editors.This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
- 2015 SpringerMichael B.A. Oldstone, Richard W. Compans, editors.Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
- 2012 SpringerGerri S. Hall, editor.Antifungal agents -- Antifungal susceptibility testing: Clinical Laboratory and Standards Institute (CLSI) methods -- Antifungal susceptibility testing methods: non-CLSI methods for yeast and moulds -- Susceptibility testing of dermatophytes -- Usual susceptibility patterns of common yeasts -- Usual susceptibility patterns of common moulds and systemic fungi -- Usual susceptibility patterns for systemic dimorphic fungi -- Utility of antifungal susceptibility testing and clinical correlations.
- 2012 SpringerK. Sasaki, O. Suzuki, N. Takahashi, editors ; P. Stashenko, ... [et al.], associate editors.
- 2014 SpringerSimon Fillatreau, Anne O'Gara, editors." This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
- 2014 CRCnetBASEeditors, Eduardo J. Schiffrin, Philippe Marteau, Dominique Brassart.1. Commensal intestinal microbiota and mucosal immune system development and function / Katarina Radulovic and Jan Hendrik Niess -- 2. Presentation of microbial signals via maternal cells : an evolutionary advantage of mammals / Pablo F. Perez, Anne Donnet-Hughes and Eduardo J. Schiffrin -- 3. Interactions of the intestinal microbiota with mucosal epithelial cells / Cherbuy Claire, Tomas Julie, Thomas Muriel and Langella Philippe -- 4. Pathogen-host cell interactions at the intestinal level : 88 lessons from cultured human fully-differentiated colon cancer Caco-2 and T84 epithelial cell lines / Vanessa Liv̌in-Le Moal and Alain L. Servin -- 5. Manipulation of the host-cell pathways by bacterial enteropathogens / Brice Sperandio and Philippe J. Sansonetti -- 6. The role of probiotics in prevention and treatment of GI infections / Christina M. Surawicz and Christopher Damman -- 7. The microbiota in inflammatory bowel disease / Philippe Marteau, Marion Leclerc, Patricia Lepage, Philippe Seksik, Harry Sokol and Joel Dor ̌-- 8. Opportunistic pathogens in inflammatory bowel disease, and the relation with specific gene susceptibilities / Marianne Fraher and Fergus Shanahan -- 9. Opportunistic pathogens in inflammatory bowel disease, the case of adherent-invasive e. coli / Arlette Darfeuille-Michaud -- 10. Correction of microbiota disturbances or antagonism against specific pathogens in IBD / Paul K. Flanagan and Jonathan M. Rhodes -- 11. Probiotics in inflammatory bowel disease : modulation of the pathological immune or inflammatory activation. Their potential benefits in the different phases of the disease / Siew C. Ng and Ailsa L. Hart -- 12. Mechanisms, prevention and management of diarrhoea in enteral nutrition / Kevin Whelan and Stp̌hane M. Schneider -- 13. Influence of the intestinal microbiota on the critically ill patient / Robert G. Martindale, Stephen A. McClave, Malissa Warren and Svetang Desai -- 14. Gut microbiota in obesity and Type-2 diabetes : links with diet and weight loss intervention / Judith Aron-Wisnewsky and Karine Clm̌ent.
- 2006 SpringerHelmut König, Ajit Varma (eds.).
- 2013 SpringerBryan R. Cullen, editor.The APOBEC3 Family of Retroelement Restriction Factors / Eric W. Refsland, Reuben S. Harris -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family / Adam J. Fletcher, Greg J. Towers -- The Antiviral Activities of Tetherin / Stuart J. D. Neil -- Restriction of Retroviral Infection of Macrophages / Mark Sharkey -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors / Welkin E. Johnson -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants / György Szittya, József Burgyán -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates / Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses / Eva Gottwein -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response / Karyn McFadden, Micah A. Luftig.
- Iron acquisition by the genus mycobacterium : history, mechanisms, role of siderocalin, anti-tuberculosis drug development2013 SpringerB. Rowe Byers, editor.Iron Acquisition by the Genus Mycobacterium summarizes the early evidence for the necessity of iron in mycobacteria and the discovery of the mycobacterial siderophores mycobactin, carboxymycobactin, and exochelin. The structural characterization of the mycobacterial siderophores is described. The genes so far identified as essential for iron acquisition and maintenance of an infection by pathogenic mycobacteria are discussed. The potential role of siderocalin in iron gathering by M. tuberculosis is featured. Because new drugs for M. tuberculosis are needed, this brief also emphasizes the design of antibiotics that interfere with siderophore biosynthesis and the use of siderophore analogs and/or conjugates.
- 2013 (27th ed.) AccessMedicine26th ed., 2010 AccessMedicineAdelberg, Edward A.; Brooks, George F.; Jawetz, Ernest; Melnick, Joseph L.Also available: Print – 1991-<2016>
- 2013 SpringerVijai Kumar Gupta, Maria G. Tuohy, editors ; Manimaran Ayyachamy, Kevin M. Turner, Anthonia O'Donovan, associate editors.Laboratory Protocols in Fungal Biology presents the latest techniques in fungal biology. This book analyzes information derived through real experiments, and focuses on cutting edge techniques in the field. The book comprises 57 chapters contributed from internationally recognised scientists and researchers. Experts in the field have provided up-to-date protocols covering a range of frequently used methods in fungal biology. Almost all important methods available in the area of fungal biology viz. taxonomic keys in fungi; histopathological and microscopy techniques; proteomics methods; genomics methods; industrial applications and related techniques; and bioinformatics tools in fungi are covered and complied in one book. Chapters include introductions to their respective topics, list of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting. Each chapter is self-contained and written in a style that enables the reader to progress from elementary concepts to advanced research techniques. Laboratory Protocols in Fungal Biology is a valuable tool for both beginner research workers and experienced professionals.
- 2007Tom Elliott, Tony Worthington, Husam Osman, Martin Gill.Basic bacteriology : structure -- Basic bacteriology : physiology -- Basic bacteriology : genetics -- Classification of bacteria -- Staphylococci -- Streptococci and enterococcci -- Clostridia -- Other gram-positive bacteria -- Gram-negative cocci -- Enterobacteriaceae -- Parvobacteri -- Pseudomonas and other aerobic gram-negative bacilli -- Campylobacter, helicobacter, and vibrios -- Treponema, borrelia, and leptospira -- Gram-negative anaerobic bacteria -- Mycobacteria -- Chlamydiae, rickettsiaceae, mycoplasma -- Basic virology -- Major virus groups -- Basic mycology and classification of fungi -- Parasitology : protozoa -- Parasitology : metazoa (helminths) -- Host-parasite relationships -- Diagnostic laboratory methods -- Epidemiology and prevention of infection -- Management of infections -- Immunisation -- Sterilisation and disinfection -- Antibacterial agents -- Antifungal agents -- Antiviral agents -- Upper respiratory tract infections -- Lower respiratory tract infections -- Gastrointestinal infections -- Liver and biliary tract infections -- Urinary tract infections -- Genital infections (including sexually transmitted diseases) -- Infections of central nervous system -- Septicaemia and bacteraemia -- Device-related infections -- Drug-resistant microorganisms -- Cardiovascular infections -- Bone and joint infections -- Skin and soft-tissue infections -- Infections in the compromised host -- Perinatal and congenital infections -- Human immunodeficiency viruses -- Miscellaneous viral infections.
- 2008 SpringerPaul Hoffman, Herman Friedman, Mauro Bendinelli.
- 2015 SpringerBen Adler, Editor.This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world?s most widespread zoonosis. Topics include aspects of human and animal leptospirosis as well as detailed analyses of our current knowledge of leptospiral structure and physiology, epidemiology, pathogenesis, genomics, immunity and vaccines. Updates are presented on leptospiral systematics, identification and diagnostics, as well as practical information on culture of Leptospira. Contact information is also provided for Leptospira reference centers. All chapters were written by experts in the field, providing an invaluable reference source for scientists, veterinarians, clinicians and all others with an interest in leptospirosis.
- 2007Richard A. Harvey, Pamela C. Champe, Bruce D. Fisher.
- 2007 CRCnetBASEedited by Elliot T. Ryser, Elmer H. Marth.The genus Listeria and Listeria monocytogenes: phylogenetic position, taxonomy, and identification / Jocelyn Rocourt and Carmen Buchrieser -- Ecology of Listeria species and L. monocytogenes in the natural environment / Brian D. Sauders and Martin Wiedmann -- Listeriosis in animals / Irene V. Wesley -- Listeriosis in humans / John Painter and Laurence Slutsker -- Molecular virulence determinants of Listeria monocytogenes / Michael Kuhn and Werner Goebel -- Characteristics of Listeria monocytogenes important to food processors / Beatrice H. Lado and Ahmed E. Yousef -- Conventional methods to detect and isolate Listeria monocytogenes / Catherine W. Donnelly and David G. Nyachuba -- Rapid methods for detection of Listeria / Byron F. Brehm-Stecher and Eric A. Johnson -- Subtyping Listeria monocytogenes / Lewis M. Graves, Bala Swaminathan, and Susan B. Hunter -- Foodborne listeriosis / Dawn M. Norton and Christopher R. Braden -- Incidence and behavior of Listeria monocytogenes in unfermented dairy products / Elliot T. Ryser -- Incidence and behavior of Listeria monocytogenes in cheese and other fermented dairy products / Elliot T. Ryser -- Incidence and behavior of Listeria monocytogenes in meat products / Jeffrey M. Farber, Franco Pagotto, and Chris Scherf -- Incidence and behavior of Listeria monocytogenes in poultry and egg products / Elliot T. Ryser -- Incidence and behavior of Listeria monocytogenes in fish and seafood / Karen C. Jinneman, Marleen M. Wekell, and Mel W. Eklund -- Incidence and behavior of Listeria monocytogenes in products of plant origin / Robert E. Brackett -- Incidence and control of Listeria in food processing facilities / Jeffrey L. Kornacki and Joshua Gurtler -- Listeria: risk assessment, regulatory control, and economic impact / Ewen C.D. Todd -- Perspectives on research needs / Elmer H. Marth ... [et al.].
- 2014 Springer Protocolsedited by Kieran Jordan, Edward M. Fox, Martin Wagner.Listeria monocytogenes is still a major threat to public health. A new book in the Methods in Molecular Biology series, Listeria monocytogenes: Methods and Protocols addresses its titular pathogen with protocols and methodologies used in research to gain a better understanding of Listeria at a molecular level. The topics covered include sampling in order to isolate Listeria, methods for their identification and characterization, methods for gene manipulation, and, finally, methods for control of the organism. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective subjects, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Vital and authoritative, Listeria monocytogenes: Methods and Protocols aims to contribute to the harmonization of the methods used in the field and will therefore benefit all those interested in Listeria research.
- 2007 Springeredited by Howard Goldfine and Hao Shen.
- 2007 Springervolume editor, Dirk Schüler.
- 2010 SpringerArch G. Mainous III, Claire Pomeroy, editors.
- v. 1-2, 2007.editor in chief, Patrick R. Murray ; editors, Ellen Jo Baron ... [et al.].Introduction to the ninth edition of the Manual of clinical microbiology -- Laboratory management -- Laboratory design -- Laboratory consultation, communication, and information systems -- General principles of specimen collection and handling -- Procedures for the storage of microorganisms -- Decontamination, disinfection, and sterilization -- Prevention and control of laboratory-acquired infections -- Laboratory detection of potential agents of bioterrorism -- Infection control epidemiology and clinical microbiology -- Laboratory procedures for the epidemiological analysis of microorganisms -- Investigation of foodborne and waterborne disease outbreaks -- Microscopy -- Principles of stains and media -- Manual and automated systems for detection and identification of microorganisms -- Molecular detection and identification of microogranisms -- Susceptibility testing instrumentation and computerized expert systems for data analysis and interpretation -- Immunoassays for the diagnosis of infectious diseases -- Taxonomy and classification of bacteria -- Specimen collection, transport, and processing: bacteriology -- Reagents, stains, and media : bacterialogy -- Algorithm for identification of aerobic gram-positive cocci -- Algorithm for identification of aerobic gram-positive rods -- Algorithms for identification of aerobic gram-negative bacteria -- Algorithm for identification of anaerobic bacteria -- Aglorithms for indentification of curved and spiral-shaped gram-negative rods -- Algorithms for identification of mycoplasma, ureaplasma, and obligate intracellular bacteria -- Staphylococcus, micrococcus, and other catalase-positive cocci -- Streptococcus -- Enterococcus -- Aerococcus, abiotrophia, and other aerobic catalase-negative, gram-positive coci -- Bacillus and other aerobic endospore-forming bacteria -- Listeria and erysipelothrix -- Coryneform gram-positive rods -- Nocardia, rhodoccus, gordonia, actinomadura, streptomyces,and other aerobic actinomycetes -- Mycobacterium : general characteristcs, laboratory detection, and staining procedures -- Mycobacterium : laboratory characteristcs of slowly growing mycobacteria -- Mycobacterium : clinical and laboratory characteristics of rapidly growing mycobacteria -- Neisseria -- Actinobacillus, capnocytophaga, eikenella, kingella, pasteurella, and other fastidious or rarely encountered gram-negative rods -- Haemophilus -- Enterobacteriaceae: introduction and identification -- Escherichia, shigella, and salmonella -- Yersinia -- Klebsiella, enterobacter, citrobacter, serratia, pleiomonas, and other enterobacteriaceae -- Aeromonas -- Vibrio and related organisms -- Pseudomonas -- Bukholderia, stenotrophomonas, ralstonia, cupriavidus, pandoraea, brevundimonas, comamonas, delftia, and acidovorax -- Acinetobacter, achromobacter, chryseobacterium, moraxella, and other nonfermentive gram-negative rods -- Bordetella -- Francisella and brucella -- Legionella -- Bartonella -- Peptostreptococcus, finegoldia, anaerococcus, peptoniphilus, veillonella, and other anerobic cocci -- Propionibacterium, lactobacillus, actinomyces, and other non-spore-forming anaerobic gram-positive rods -- Clostridium -- Bacterioides, porphyromonas, prevotella, fusobacterium, and other anaerobic gram-negative rods -- Campylobacter and arcobacter -- Helicobacter -- Leptospira -- Borrelia -- Treponema and other human host-associated spirochetes -- Mycoplasma and ureaplasma -- Chlamydia and chlamydophila -- Rickettsia and orientia -- Ehrlichia, anaplasma, and related intracellular bacteria -- Coxiella -- Tropheryma -- Antibacterial agents -- Mechanisms of resistance to antibacterial agents -- Susceptibility test methods: general considerations -- Susceptibility test methods: dilution and disk diffusion methods -- Special phenotypic methods for detecting antibacterial resistance -- Susceptibility test methods: fastidious bacteria -- Susceptibility test methods: anaerobic bacteria -- Suseptibility test methods : mycobacteria, nocardia, and other actinomycetes -- Detection and characterization of antimicrobial reistance genes in pathogenic bacteria -- Taxonomy and classification of viruses -- Specimen collection, transport, and processing : virology -- Reagents, stains, media, and cell lines : virology -- Algorithms for detection and identification of viruses -- Human immunodeficiency viruses -- Human T-cell lymphotropic virus types 1 and 2 -- Influenza viruses -- Parainfluenza and mumps viruses -- Respiratory syncytial virus and human metapneumovirus -- Measles and rubella viruses -- Enteroviruses and parechoviruses -- Rhinoviruses -- Coronaviruses -- Hepatitis A and E viruses -- Heptatitis C and G viruses -- Rotaviruses, caliciviruses, astrofiruses, enteric adenoviruses, and other diarrheic viruses -- Rabies virus -- Hendra and nipah viruses -- Arboviruses -- Hantaviruses -- Arenaviruses and filoviruses -- Herpes simplex viruses and herpes B virus -- Varicella-zoster virus -- Human cytomegalovirus -- Epstein-Barr virus-- Human herpesviruses 6, 7, and 8 -- Adenoviruses - Human papillomaviruses -- Human polyomaviruses -- Human parvoviruses -- Poxviruses -- Hepatitis B and D viruses -- Transmissible spongiform encephalopathies -- Antiviral agents -- Mechanisms of resistance to antiviral agents --- Suseptibility test methods: viruses -- Taxonomy and classification of fungi -- Specimen collection, transport, and processing : mycology -- Reagents, stains, and media : mycology -- Algorithms for detection and identification of fungi -- Candida, cryptococcus, and other yeasts of medical importance -- Pneumocystis -- Aspergillus, fusarium, and other opportunisitc moniliaceous fungi -- Rhizopus, rhizomucor, absidia, and other agents of systemic and subcutaneous zygomycoses -- Histoplasma, blastomyces, coccidioides, and other dimorphic fungi causing systemic mycoses -- Trichophyton, microsporum, epidermophyton, and agents of superficial mycoses -- Bipolaris, exophiala, scedosporium, sporothrix, and other dematiaceous -- Fungi causing eumycotic mycetoma -- Mycotoxins -- Lacazia pythium, and rhinosporidium -- Antifungal agents -- Mechanisms of resistance to antifungal agents -- Susceptibility test methods : yeasts and filamentous fungi -- Taxonomy and classification of human parasites -- Specimen collection, transport, and processing : parasitology -- Reagents, stains, and media : parasitology -- Algorithms for detection and identification of parasites -- Plasmodium and babesia -- Leishmania and trypanosoma -- Toxoplasma -- Pathogenic and opportunistic free-living amebae -- Intestinal and urogenital amebae, flagellates, and ciliates -- Isopora, cyclospora, and sarcocystis -- Cryptosporidium -- Microsporidia -- Nematodes -- Filarial nematodes -- Cestodes -- Trematodes -- Less common helminths -- Arthropods of medical importance -- Antiparasitic agents -- Mechanisms of resistance to antiparasitic agents -- Susceptibility test methods: parasites.
- 2015 ASMeditors in chief, James H. Jorgensen, Emeritus, Department of Pathology, University of Texas Health Science Center, San Antonio, Texas, Michael A. Pfaller, T2 Biosystems, Lexington, Massachusetts, and Professor Emeritus, University of Iowa College of Medicine, Iowa City, Iowa ; volume editors, Karen C. Carroll, Department of Pathology, Division of Microbiology, The Johns Hopkins University School of Medicine, Baltimore, Maryland [and 4 others].V. 1: Introduction to the 11th Edition of the Manual of Clinical Microbiology -- Microscopy -- Laboratory Detection of Bacteremia and Fungemia -- Systems for Identification of Bacteria and Fungi -- Automation and Design of the Clinical Microbiology Laboratory -- Molecular Microbiology -- Immunoassays for Diagnosis of Infectious Diseases -- Prevention of Health Care-Associated Infections -- Investigation of Disease Outbreaks -- Molecular Epidemiology -- Procedures for the Storage of Microorganisms -- Prevention of Laboratory-Acquired Infections -- Decontamination, Disinfection, and Sterilization -- Biothreat Agents -- The Human Microbiome -- Microbial Genomics and Pathogen Discovery -- Taxonomy and Classification of Bacteria -- Specimen Collection, Transport, and Processing: Bacteriology -- Reagents, Stains, and Media: Bacteriology -- General Approaches to Identification of Aerobic Gram-Positive Cocci -- Staphylococcus, Micrococcus, and Other Catalase-Positive Cocci -- Streptococcus -- Enterococcus -- Aerococcus, Abiotrophia, and Other Aerobic Catalase-Negative, Gram-Positive Cocci -- General Approaches to the Identification of Aerobic Gram-Positive Rods -- Bacillus and Other Aerobic Endospore-Forming Bacteria -- Listeria and Erysipelothrix -- Coryneform Gram-Positive Rods -- Nocardia, Rhodococcus, Gordonia, Actinomadura, Streptomyces, and Other Aerobic Actinomycetes -- Mycobacterium: General Characteristics, Laboratory Detection, and Staining Procedures -- Mycobacterium: Laboratory Characteristics of Slowly Growing Mycobacteria -- Mycobacterium: Clinical and Laboratory Characteristics of Rapidly Growing Mycobacteria -- Approaches to the Identification of Aerobic Gram-Negative Bacteria -- Neisseria -- Aggregatibacter, Capnocytophaga, Eikenella, Kingella, Pasteurella, and Other Fastidious or Rarely Encountered Gram-Negative Rods -- Haemophilus -- Escherichia, Shigella, and Salmonella -- Klebsiella, Enterobacter, Citrobacter, Cronobacter, Serratia, Plesiomonas, and Other Enterobacteriaceae -- Yersinia -- Aeromonas -- Vibrio and Related Organisms -- Pseudomonas -- Burkholderia, Stenotrophomonas, Ralstonia, Cupriavidus, Pandoraea, Brevundimonas, Comamonas, Delftia, and Acidovorax -- Acinetobacter, Chryseobacterium, Moraxella, and Other Nonfermentative Gram-Negative Rods -- Bordetella and Related Genera -- Francisella -- Brucella -- Bartonella -- Legionella -- Approaches to Identification of Anaerobic Bacteria -- Peptostreptococcus, Finegoldia, Anaerococcus, Peptoniphilus, Veillonella, and Other Anaerobic Cocci -- Propionibacterium, Lactobacillus, Actinomyces, and Other Non-Spore-Forming Anaerobic Gram-Positive Rods -- Clostridium -- Bacteroides, Porphyromonas, Prevotella, Fusobacterium, and Other Anaerobic Gram-Negative Rods -- Algorithms for Identification of Curved and Spiral-Shaped Gram-Negative Rods -- Campylobacter and Arcobacter -- Helicobacter -- Leptospira -- Borrelia -- Treponema and Brachyspira, Human Host-Associated Spirochetes -- General Approaches to Identification of Mycoplasma, Ureaplasma, and Obligate Intracellular Bacteria -- Mycoplasma and Ureaplasma -- Chlamydiaceae -- Rickettsia and Orientia -- Ehrlichia, Anaplasma, and Related Intracellular Bacteria -- Coxiella -- Tropheryma whipplei -- Antibacterial Agents -- Mechanisms of Resistance to Antibacterial Agents -- Susceptibility Test Methods: General Considerations -- Susceptibility Test Methods: Dilution and Disk Diffusion Methods -- Antimicrobial Susceptibility Testing Systems -- Special Phenotypic Methods for Detecting Antibacterial Resistance -- Susceptibility Test Methods: Fastidious Bacteria -- Susceptibility Test Methods: Anaerobic Bacteria -- Susceptibility Test Methods: Mycobacteria, Nocardia, and Other Actinomycetes -- Molecular Detection of Antibacterial Drug Resistance. V. 2: Taxonomy and Classification of Viruses -- Specimen Collection, Transport, and Processing: Virology -- Reagents, Stains, Media, and Cell Cultures: Virology -- Algorithms for Detection and Identification of Viruses -- Human Immunodeficiency Viruses -- Human T-Cell Lymphotropic Viruses -- Influenza Viruses -- Parainfluenza and Mumps Viruses -- Respiratory Syncytial Virus and Human Metapneumovirus -- Measles and Rubella Viruses -- Enteroviruses and Parechoviruses -- Rhinoviruses -- Coronaviruses -- Hepatitis A and E Viruses -- Hepatitis C Virus -- Gastroenteritis Viruses -- Rabies Virus -- Arboviruses -- Hantaviruses -- Arenaviruses and Filoviruses -- Herpes Simplex Viruses and Herpes B Virus -- Varicella-Zoster Virus -- Human Cytomegalovirus -- Epstein-Barr Virus -- Human Herpesviruses -- Adenoviruses -- Human Papillomaviruses -- Human Polyomaviruses -- Parvovirus B19 and Bocaviruses -- Poxviruses -- Hepatitis B and D Viruses -- Transmissible Spongiform Encephalopathies -- Antiviral Agents -- Mechanisms of Resistance to Antiviral Agents -- Susceptibility Test Methods: Viruses -- Taxonomy and Classification of Fungi -- Specimen Collection, Transport, and Processing: Mycology -- Reagents, Stains, and Media: Mycology -- General Approaches for Direct Detection and Identification of Fungi -- Candida, Cryptococcus, and Other Yeasts of Medical Importance -- Pneumocystis -- Aspergillus and Penicillium -- Fusarium and Other Opportunistic Hyaline Fungi -- Agents of Systemic and Subcutaneous Mucormycosis and Entomophthoromycosis -- Histoplasma, Blastomyces, Coccidioides, and Other Dimorphic Fungi Causing Systemic Mycoses -- Trichophyton, Microsporum, Epidermophyton, and Agents of Superficial Mycoses -- Curvularia, Exophiala, Scedosporium, Sporothrix, and Other Melanized Fungi -- Fungi Causing Eumycotic Mycetoma -- Mycotoxins -- Lacazia, Lagenidium, Pythium, and Rhinosporidium -- Microsporidia -- Antifungal Agents -- Mechanisms of Resistance to Antifungal Agents -- Susceptibility Test Methods: Yeasts and Filamentous Fungi -- Taxonomy and Classification of Human Parasitic Protozoa and Helminths -- Specimen Collection, Transport, and Processing: Parasitology -- Reagents, Stains, and Media: Parasitology -- General Approaches for Detection and Identification of Parasites -- Plasmodium and Babesia -- Leishmania and Trypanosoma -- Toxoplasma -- Pathogenic and Opportunistic Free-Living Amebae -- Intestinal and Urogenital Amebae, Flagellates, and Ciliates -- Cystoisospora, Cyclospora, and Sarcocystis -- Cryptosporidium -- Nematodes -- Filarial Nematodes -- Cestodes -- Trematodes -- Less Common Helminths -- Arthropods of Medical Importance -- Antiparasitic Agents -- Mechanisms of Resistance to Antiparasitic Agents -- Susceptibility Test Methods: Parasites.
- 2001 ScienceDirectedited by John H. Paul.Also available: Print – 2001
- 2005 Kargervolume editors: Dieter Kabelitz, Jens-Michael Schröder.Also available: Print – 2005
- 2009Patrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller.
- 2012 ClinicalKeyedited by David Greenwood [and others].Microbiology and medicine -- Morphology and nature of micro-organisms -- Classification, identification and typing of micro-organisms -- Bacterial growth, physiology and death -- Antimicrobial agents -- Bacterial genetics -- Virus-cell interactions -- Immunological principles: Antigens and antigen recognition -- Innate and acquired immunity -- Immunity in viral infections -- Parasitic infections: Pathogenesis and immunity -- Immunity in bacterial infections -- Bacterial pathogenicity -- The natural history of infection -- Staphylococcus: Skin infections; osteomyelitis; bloodstream infection; food poisoning; foreign body infections; MRSA -- Streptococcus and enterococcus: Pharyngitis; scarlet fever; skin and soft tissue infections; streptococcal toxic shock syndrome; pneumonia; meningitis; urinary tract infections; rheumatic fever; post-streptococcal glomerulonephritis -- Coryneform bacteria, listeria and erysipelothrix: Diphtheria; listeriosis; erysipeloid -- Mycobacterium: Tuberculosis; leprosy -- Environmental mycobacteria: Opportunist disease -- Actinomyces, nocardia and tropheryma: Actinomycosis; nocardiasis; Whipple's disease -- Bacillus: Anthrax; food poisoning -- Clostridium: Gas gangrene; tetanus; food poisoning; pseudomembranous colitis -- Neisseria and moraxella: Meningitis; septicaemia; gonorrhoea; respiratory infections -- Salmonella: Food poisoning; enteric fever -- Shigella: Bacillary dysentery -- Escherichia: Urinary tract infection; travellers' diarrhoea; haemorrhagic colitis; haemolytic uraemic syndrome -- Klebsiella, enterobacter, proteus and other enterobacteria: Pneumonia; urinary tract infection; opportunist infection -- Pseudomonads and non-fermenters: Opportunist infection; cystic fibrosis; melioidosis -- Campylobacter and helicobacter: Enteritis; polyneuropathy; gastritis; peptic ulcer disease; gastric cancer -- Vibrio, mobiluncus, gardnerella and spirillum: Cholera; vaginosis; rat bite fever -- Haemophilus: Respiratory infections; meningitis; chancroid -- Bordetella: Whooping cough -- Legionella: Legionnaires' disease; Pontiac fever -- Brucella, bartonella and streptobacillus: Brucellosis; Oroya fever; trench fever; cat scratch disease; bacillary angiomatosis; rat bite fever -- Yersinia, pasteurella and francisella: Plague; pseudotuberculosis; mesenteric adenitis; pasteurellosis; tularaemia -- Non-sporing anaerobes: Wound infection; periodontal disease; abscess; normal flora -- Treponema and borrelia: Syphilis; yaws; relapsing fever; Lyme disease -- Leptospira: Leptospirosis; Weil's disease -- Chlamydia: Genital and ocular infections; infertility; atypical pneumonia -- Rickettsia, orientia, ehrlichia, anaplasma and coxiella: Typhus; spotted fevers; scrub typhus; ehrlichioses; Q fever -- Mycoplasmas: Respiratory and genital tract infections -- Adenoviruses: Respiratory disease; conjunctivitis; gut infections -- Herpesviruses: Herpes simplex; varicella and zoster; infectious mononucleosis; B cell lymphomas; cytomegalovirus disease; exanthem subitum; Kaposi's sarcoma; herpes B -- Poxviruses: Smallpox; molluscum contagiosum; parapoxvirus infections -- Papillomaviruses and polyomaviruses: Warts: warts and cancers; polyomavirus associated nephropathy; progressive multifocal leuco-encephalopathy -- Hepadnaviruses: Hepatitis B virus infection; hepatitis delta virus infection -- Parvoviruses: B19 infection; erythema infectiosum -- Picornaviruses: Meningitis; paralysis; rashes; intercostal myositis; myocarditis; infectious hepatitis; common cold -- Orthomyxoviruses: Influenza -- Paramyxoviruses: Respiratory infections; mumps; measles; Hendra/Nipah disease -- Arboviruses: alphaviruses, flaviviruses and bunyaviruses: Encephalitis; yellow fever; dengue; haemorrhagic fever; miscellaneous tropical fevers; undifferentiated fever -- Hepaciviruses and hepeviruses: Hepatitis C and E viruses; non-A, non-B hepatitis -- Arenaviruses and filoviruses: Viral haemorrhagic fevers -- Reoviruses: Gastroenteritis -- Retroviruses: Acquired immune deficiency syndrome; HTLV-1 -- Caliciviruses and astroviruses: Diarrhoeal disease -- Coronaviruses -- Rhabdoviruses -- Togaviruses: Rubella -- Prion diseases (transmissible spongiform encephalopathies): Creutzfeldt-Jakob disease; Gerstmann-Sträussler-Scheinker syndrome; fatal familial insomnia; iatrogenic Creutzfeldt-Jakob disease; kuru; variant Creutzfeldt-Jakob disease; bovine spongiform encephalopathy; scrapie-- Fungi: Superficial, subcutaneous and systemic mycoses -- Protozoa: Malaria; toxoplasmosis; cryptosporidiosis; amoebiasis; trypanosomiasis; leishmaniasis; giardiasis; trichomoniasis -- Helminths: Intestinal worm infections; filariasis; schistosomiasis; hydatid disease -- Arthropods: Arthropod-borne diseases; ectoparasitic infections; allergy -- Infective syndromes -- Diagnostic procedures -- Strategy of antimicrobial chemotherapy -- Epidemiology and control of community infections -- Hospital infection -- Immunization.
- 2016 ClinicalKeyPatrick R. Murray, Ken S. Rosenthal, Michael A. Pfaller.Introduction to medical microbiology -- Human microbiome in health and disease -- Sterilization, disinfection, and antisepsis -- Microscopy and in vitro culture -- Molecular diagnosis -- Serologic diagnosis -- Elements of host protective responses -- Innate host responses -- Antigen-specific immune responses -- Immune responses to infectious agents -- Antimicrobial vaccines -- Bacterial classification, structure, and replication -- Bacterial metabolism and genetics -- Mechanisms of bacterial pathogenesis -- Role of bacteria in disease -- Laboratory diagnosis of bacterial diseases -- Antibacterial agents -- Staphylococcus and related gram-positive cocci -- Streptococcus and Enterococcus -- Bacillus -- Listeria and related gram-positive bacteria -- Mycobacterium and related acid-fast bacteria -- Neisseria and related genera -- Haemophilus and related bacteria -- Enterobacteriaceae -- Vibrio and related bacteria -- Pseudomonas and related bacteria -- Campylobacter and helicobacter -- Miscellaneous gram-negative rods -- Clostridium -- Non-spore-forming anaerobic bacteria -- Treponema, Borrelia, and Leptospira -- Mycoplasma and Ureaplasma -- Rickettsia, Ehrlichia, and related bacteria -- Chlamydia and Chlamydophila -- Viral classification, structure, and replication -- Mechanisms of viral pathogenesis -- Role of viruses in disease -- Laboratory diagnosis of viral diseases -- Antiviral agents and infection control -- Papillomaviruses and polyomaviruses -- Adenoviruses -- Human herpesviruses -- Poxviruses -- Parvoviruses -- Picornaviruses -- Coronaviruses and noroviruses -- Paramyxoviruses -- Orthomyxoviruses -- Rhabdoviruses, Filoviruses, and Bornaviruses -- Reoviruses -- Togaviruses and flaviviruses -- Bunyaviridae and Arenaviridae -- Retroviruses -- Hepatitis viruses -- Prion diseases -- Fungal classification, structure, and replication -- Pathogenesis of fungal disease -- Role of fungi in disease -- Laboratory diagnosis of fungal disease -- Antifungal agents -- Superficial and cutaneous mycoses -- Subcutaneous mycoses -- Systemic mycoses caused by dimorphic fungi -- Opportunistic mycoses -- Fungal and fungal-like infections of unusual or uncertain etiology -- Mycotoxins and mycotoxicoses -- Parasitic classification, structure, and replication -- Pathogenesis of parasitic diseases -- Role of parasites in disease -- Laboratory diagnosis of parasitic disease -- Antiparasitic agents -- Intestinal and urogenital protozoa -- Blood and tissue protozoa -- Nematodes -- Trematodes -- Cestodes -- Arthropods.
- 2006 NCBI BookshelfAcid mine drainage biofilm -- Waseca County farm soil -- Whale fall community -- Methane-oxidizing archaea -- Human fecal virus -- Sargasso Sea marine microbial metagenome -- Human distal gut microbiome -- Enhanced biological phosphorus removal (EBPR) sludge community -- Mouse gut microbiota metagenome.
- 2012 WileyPrakash S. Bisen, Mousumi Debnath, Godavarthi B.K.S. Prasad.
- 2011 SpringerG.N. Cohen.Bacterial growth -- The outer membrane of gram-negative bacteria and the cytoplasmic membrane -- Peptidoglycan synthesis and cell division -- Cellular permeability -- Allosteric enzymes -- Glycolysis, gluconeogenesis and glycogen synthesis -- The pentose phosphate and Entner-Doudoroff pathways -- The tricarboxylic acid cycle and the glyoxylate bypass -- ATP-generating processes : respiration and fermentation -- Biosynthesis of lipids -- Iron-sulfur proteins -- The archaea -- Methanogens and methylotrophs -- Enzyme induction in catabolic systems -- Transcription : RNA polymerase -- Negative regulation -- Enzyme repression in anabolic pathways -- Positive regulation -- The ribosomes -- The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases -- Attenuation -- Riboswitches -- The biological fixation of nitrogen -- How biosynthetic pathways have been established -- The aspartic acid family of amino acids : biosynthesis -- Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae -- Other patterns of regulation of the synthesis of amino acids of the aspartate family -- Biosynthesis of the amino acids of the glutamic acid family and its regulation -- Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid -- Selenocysteine and selenoproteins -- Biosynthesis of aromatic amino acids and its regulation -- The biosynthesis of histidine and its regulation -- The biosynthesis of nucleotides -- The biosynthesis of deoxyribonucleotides -- Biosynthesis of some water-soluble vitamins and of their coenzyme forms -- Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones -- Biosynthesis of the tetrapyrrole ring system -- Biosynthesis of cobalamins including vitamin B12 -- Interactions between proteins and DNA -- Evolution of biosynthetic pathways.
- 2014 Springer Protocolsedited by Gianfranco Donelli.Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms / Claus Sternberg, Thomas Bjarnsholt, and Mark Shirtliff -- Aqueous two-phase system technology for patterning bacterial communities and biofilms / Mohammed Dwidar, Shuichi Takayama, and Robert J. Mitchell -- Quorum sensing in gram-positive bacteria : assay protocols for Staphylococcal agr and Enterococcal fsr systems / Akane Shojima and Jiro Nakayama -- Advanced techniques for in situ analysis of the biofilm matrix (structure, composition, dynamics) by means of laser scanning microscopy / Thomas R. Neu and John R. Lawrence -- Multiplex fluorescence in situ hybridization (M-FISH) and confocal laser scanning microscopy (CLSM) to analyze multispecies oral biofilms / Lamprini Karygianni, Elmar Hellwig, and Ali Al-Ahmad -- Field emission scanning electron microscopy of biofilm-growing bacteria Involved in nosocomial infections / Claudia Vuotto and Gianfranco Donelli -- Experimental approaches to investigating the vaginal biofilm microbiome / Marc M. Baum, Manjula Gunawardana, and Paul Webster -- Imaging bacteria and biofilms on hardware and periprosthetic tissue in orthopedic infections / Laura Nistico, Luanne Hall-Stoodley, and Paul Stoodley -- Animal models to evaluate bacterial biofilm development / Kim Thomsen, Hannah Trøstrup, and Claus Moser -- Animal models to investigate fungal biofilm formation / Jyotsna Chandra, Eric Pearlman, and Mahmoud A. Ghannoum -- Nonmammalian model systems to investigate fungal biofilms / Marios Arvanitis ... [et al.] -- Microbiological methods for target-oriented screening of biofilm inhibitors / Livia Leoni and Paolo Landini -- In vitro screening of antifungal compounds able to counteract biofilm development / Marion Girardot and Christine Imbert -- Biofilm matrix-degrading enzymes / Jeffrey B. Kaplan -- Efficacy evaluation of antimicrobial drug-releasing polymer matrices / Iolanda Francolini, Antonella Piozzi, and Gianfranco Donelli -- Antibiotic polymeric nanoparticles for biofilm-associated infection therapy / Wean Sin Cheow and Kunn Hadinoto -- Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo / Wang Hengzhuang, Niels Høiby, and Oana Ciofu -- Contribution of confocal laser scanning microscopy in deciphering biofilm tridimensional structure and reactivity / Arnaud Bridier and Romain Briandet -- Chip calorimetry for evaluation of biofilm treatment with biocides, antibiotics, and biological agents / Frida Mariana Morais, Friederike Buchholz, and Thomas Maskow -- Bacteriophage attack as an anti-biofilm strategy / Sanna Sillankorva and Joana Azeredo -- Photodynamic therapy as a novel antimicrobial strategy against biofilm-based nosocomial infections : study protocols / Francesco Giuliani -- Capturing air-water interface biofilms for microscopy and molecular analysis / Margaret C. Henk -- Biofilm-growing bacteria involved in the corrosion of concrete wastewater pipes : protocols for comparative metagenomic analyses/ Vicente Gomez-Alvarez -- Culture-independent methods to study subaerial biofilm growing on biodeteriorated surfaces of stone cultural heritage and frescoes / Francesca Cappitelli, Federica Villa, and Andrea Polo -- Biofilms of thermophilic bacilli isolated from dairy processing plants and efficacy of sanitizers / Sara A. Burgess, Denise Lindsay, and Steve H. Flint.
- 2012 Springer Protocolsedited by José-Luis Barredo.Pathways of carotenoid biosynthesis in bacteria and microalgae / J. Paniagua-Michel, Jorge Olmos-Soto, and Manuel Acosta Ruiz -- Selection and taxonomic identification of carotenoid-producing marine actinomycetes / Francisco Romero -- Isolation, characterization, and diversity of novel radiotolerant carotenoid-producing bacteria / Dalal Asker [and others] -- Novel radio-tolerant astaxanthin-producing bacterium reveals a new astaxanthin derivative : astaxanthin dirhamnoside / Dalal Asker [and others] -- Novel zeaxanthin-producing bacteria isolated from a radioactive hot spring water / Dalal Asker [and others] -- Novel approach in the biosynthesis of functional carotenoids in Escherichia coli / Hisashi Harada and Norihiko Misawa -- Engineering Escherichia coli for canthaxanthin and ataxanthin biosynthesis / Qiong Cheng and Luan Tao -- Analysis of canthaxanthin production by Gordonia jacobaea / Patricia Veiga-Crespo [and others] -- Isolation and light-stimulated expression of canthaxanthin and spirilloxanthin biosynthesis genes from the photosynthetic bacterium Bradyrhizobium sp. Strain ORS278 / Eric Giraud and Andre Vermeglio -- Construction of carotenoid biosynthetic pathways through chromosomal integration in methane-utilizing bacterium Methylomonas sp. strain 16a / Rick W. Ye and Kristen Kelly -- Genetic modification in Bacillus subtilis for production of C30 carotenoids / Isamu Maeda -- Carotenoids' production from halophilic bacteria / Maria de Lourdes Moreno [and others] -- Construction and utilization of carotenoid reporter systems : identification of chromosomal integration sites that support suitable expression of biosynthetic genes and pathways / Pamela L. Sharpe and Deana J. DiCosimo -- Directed evolution of carotenoid synthases for the production of unnatural carotenoids / Maiko Furubayashi and Daisuke Umeno -- High-Throughput Screen for the Identi fi cation of improved catalytic activity: b-carotene hydroxylase / Mark A. Scaife [and others] -- DNA fingerprinting intron-sizing method to accomplish a specific, rapid, and sensitive identification of carotenogenic Dunaliella species / Jorge Olmos-Soto [and others] -- Ketocarotenoid biosynthesis in transgenic microalgae expressing a foreign beta-C-4-carotene oxygenase gene / Marta Vila [and others] -- Characterization of carotenogenesis genes in the cyanobacterium Anabaena sp. PCC 7120 / Hajime Masukawa, Mari Mochimaru, and Shinichi Takaichi -- Obtaining lutein-rich extract from microalgal biomass at preparative scale / Jose M. Fernandez-Sevilla, F. Gabriel Acien Fernandez, and Emilio Molina Grima -- NMR-based isotopologue profiling of microbial carotenoids / Eva Eylert, Adelbert Bacher, and Wolfgang Eisenreich -- Analysis of diapocarotenoids found in pigmented Bacillus species / Laura Perez-Fons and Paul D. Fraser.
- 2012 Springer Protocolsedited by José-Luis Barredo.
- 2013 Future Mededitor, Vladimir Krcméry.Antibiotic resistance : postantibiotic era is here / Vladimir Krcmery -- Current challenges in treating methicillin-resistant Staphylococcus aureus : what are the options? / Noha E.I. Sakka & Ian M . Gould -- Antimicrobial-resistant Streptococcus pneumoniae : trends and management / Michael R. Jacobs -- Emergence and management of drug-resistant enterococcal infections / William R. Miller, Barbara E. Murray & Cesar A. Arias -- Enterobacteriaceae that produce newer b-lactamases / Johann D.D. Pitout -- Extensively drug-resistant tuberculosis : new strains, new challenges / Megan Coffee -- Clinical significance of extended-spectrum b-lactamases / Jesés Rodréguez-Baño, Belén Gutiérrez, Lorena Lépez-Cerero & Alvaro Pascual -- Plasmid-mediated quinolone resistance / José Manuel Rodréguez-Marténez, Maréa Eliecer Cano, Jorge Calvo, Álvaro Pascual & Luis Marténez-Marténez -- Antibiotic resistance in the absence of antimicrobial use / Lucia Pallecchi, Alessandro Bartoloni, Eduardo Gotuzzo & Gian Maria Rossolini -- Resistance in bacteria of the food chain : epidemiology and control strategies / Lina Maria Cavaco & Frank Møller Aarestrup -- Measures to prevent antimicrobial resistance / Vhairi M. Bateman & Ian M. Gould -- Where does novel antibiotics R&D stand among other pharmaceutical products? / Glenn S. Tillotson -- Resistance to antiretroviral drugs / Manuela Colafigli, Simona Di Giambenedetto & Roberto Cauda -- Index.
- 2012Miling Yan.The establishment and wide acceptance of an abundant and diverse human-associated microbial community has been one of the most important shifts in the field of microbiology in the past decade. From a bacterial perspective, the body is a vast landscape whose shifting geography and fluctuating environmental conditions provide a range of distinct residential possibilities. Some habitats, such as the intestinal tract and the oral cavity, have been characterized more extensively than others; within these environs, an understanding of the interplay between microbial ecology and health and disease has begun to emerge. The nasal cavity, a crucial component of both the respiratory system and innate immune system, has yet to benefit from an exploration of similar depth. Recent examination of the nasal microbial habitat has almost exclusively focused on the anterior nares without examining deeper sites within the cavity which are actively involved in nasal mucociliary clearance and exposed to the efflux of various sinuses. The aim of this work was to explore this biogeography by characterizing the microbial communities in a range of spatial sites along the nasal passageway. Additionally, the nasal cavity has long been a source of pathogens, most notably Staphylococcus aureus. Carriage of S. aureus has been demonstrated to be a significant risk factor for acquisition of antibiotic resistant strains of S. aureus and hospital-acquired infections. The second aim of this project was to understand whether underlying community features may be present that were characteristic of S. aureus carriage. 13 healthy subjects (6 persistent and 7 non-persistent carriers) were sampled weekly at 3 different sites (anterior nares, middle meatus, and sphenoethmoidal recess) within the nasal cavity over a 4-week period. The data shows that biogeographical differences were based less upon spatial factors and more on epithelium type. The data also showed that the S. aureus carriage type of the individual contributed the greatest amount of non-S. aureus variation within the communities. Finally, a carriage-classifying model was generated from the data and examined for important predictive features, revealing a potential intra-genus, interspecific competitive interaction in Corynebacterium with implications on S. aureus carriage. These results highlight the complexity present in human microbial communities even within highly spatially constrained microenvironments.
- Microbial endocrinology : interkingdom signaling in infectious disease and health. Second edition [2nd ed.]2016 Springereditor, Mark Lyte.Microbial Endocrinology: An Ongoing Personal Journey -- New Trends and Perspectives in Evolutionary Considerations of Neurotransmitters in Microbial, Plant and Animal Cells -- Catecholamine-directed Epithelial Cell Interactions With Bacteria in the Intestinal Mucosa -- Modulation of the Interaction of Enteric Bacteria with Intestinal Mucosa -- Dietary Catechols and their Relationship to Microbial Endocrinology -- Mechanisms by Which Catecholamines Induce Growth in Gram-Negative and Gram-Positive Human Pathogens -- Molecular Profiling: Catecholamine Modulation of Gene Expression in Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium -- Microbial Endocrinology of Pseudomonas aeruginosa -- Interkingdom Chemical Signaling in Enterohemorrhagic Escherichia coli O157:H7 -- Role of Microbial Endocrinology in Periodontal Disease -- Staphylococci, Catecholamine Inotropes and Hospital-Acquired Infections -- Experimental Design Considerations for In Vitro Microbial -- The Role of the Microbiome in the Relationship of Asthma and Affective Disorders -- Psychological Stress, Immunity and Effects on Indigenous Flora -- Microbiome to Brain: Unraveling the Multidirectional Axes of Communication -- Mycologic Endocrinology.Also available: Print – 2016
- 2010 SpringerMark Lyte, Primrose P.E. Freestone, editors.
- 2008 CRCnetBASEedited by Charles L. Wilson.Preface: Food--A Necessity and a Threat -- Editor -- Contributors -- Section I. Instances and Nature of Microbial Food Contamination -- 1. PulseNet and Emerging Foodborne Diseases / Efrain M. Ribot, Eija Hyytia-Trees, and Kara Cooper -- 2. Pathogenic Mechanisms of the Enterohemorrhagic
- 2008 Springer Protocolsedited by Andrei L. Osterman, Svetlana Y. Gerdes.Overview of whole-genome essentiality analysis / Karen Joy Shaw -- Pt. I. Experimental protocols. IA. Populational genome-wide essentiality screens. Transposon-based strategies for the identification of essential bacterial genes / William S. Reznikoff and Kelly M. Winterberg -- Identification and analysis of essential genes in Haemophilus influenzae / Sandy M.S. Wong and Brian J. Akerley -- Transposon site hybridization in Mycobacterium tuberculosis / Jeffrey P. Murry ... [et al.] -- Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis / François Sanschagrin, Irena Kukavica-Ibrulj, and Roger C. Levesque -- Whole-genome detection of conditionally essential and dispensable genes in Escherichia coli via genetic footprinting / Michael D. Scholle and Svetlana Y. Gerdes -- Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis / Taeok Bae ... [et al.] -- Multipurpose transposon insertion libraries for large-scale analysis of gene function in yeast / Anuj Kumar -- IB. Systematic collections of knockout mutants. How to make a defined near-saturation mutant library. Case 1: Pseudomonas aeruginosa PAO1 / Michael A. Jacobs -- Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality / Nicole T. Liberati ... [et al.] -- The construction of systematic in-frame, single-gene knockout mutant collection in Escherichia coli K-12 / Tomoya Baba and Hirotada Mori -- The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12 / Tomoya Baba ... [et al.] -- A novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12 / Takeyoshi Miki, Yoshihiro Yamamoto, and Hideo Matsuda -- High-throughput creation of a whole-genome collection of yeast knockout strains / Angela M. Chu and Ronald W. Davis -- Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray / Pamela B. Meluh ... [et al.] -- IC. Genome minimization. Scarless engineering of the Escherichia coli genome / Tamás Fehér ... [et al.] -- Minimization of the Escherichia coli genome using the Tn5-targeted Cre/loxP excision system / Byung Jo Yu and Sun Chang Kim -- Construction of long chromosomal deletion mutants of Escherichia coli and minimization of the genome / Jun-ichi Kato and Masayuki Hashimoto -- ID. Conditional knockouts. Identification of essential genes in Staphylococcus aureus by construction and screening of conditional mutant library / Dezhong Yin and Yinduo Ji -- Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus / Allyn Forsyth and Liangsu Wang -- Introduction of conditional lethal amber mutations in Escherichia coli / Christopher D. Herring -- Pt. II. Bioinformatics. IIA. Statistics. Statistical methods for building random transposon mutagenesis libraries / Oliver Will -- Statistical evaluation of genetic footprinting data / Gábor Balázsi -- Modeling competitive outgrowth of mutant populations : why do essentiality screens yield divergent results? / Alexander I. Grenov and Svetlana Y. Gerdes -- Statistical analysis of fitness data determined by TAG hybridization on microarrays / Brian D. Peyser, Rafael Irizarry, and Forrest A. Spencer -- IIB. Data integration and modeling. Profiling of Escherichia coli chromosome database / Yukiko Yamazaki, Hironori Niki, and Jun-ichi Kato -- Gene essentiality analysis based on DEG, a database of essential genes / Chun-Ting Zhang and Ren Zhang -- Detection of essential genes in Streptococcus pneumoniae using bioinformatics and allelic replacement mutagenesis / Jae-Hoon Song and Kwan Soo Ko -- Design and application of genome-scale reconstructed metabolic models / Isabel Rocha, Jochen Förster, and Jens Nielsen -- Predicting gene essentiality using genome-scale in silico models / Andrew R. Joyce and Bernhard Ø. Palsson -- Comparative approach to analysis of gene essentiality / Andrei L. Osterman and Svetlana Y. Gerdes.
- 2003 CRCnetBASE[edited by] Thomas J. Dougherty, Steven J. Projan.Also available: Print – 2003
- 2009 ScienceDirecteditor-in-chief, Anthony P. Moran ; editors, Otto Holst, Patrick J. Brennan, Mark von Itzstein.
- 2005 ScienceDirectedited by Tor Savidge and Charalabos Pothoulakis.Also available: Print – 2005
- 2007 Springervolume editors: Friedhelm Meinhardt, Roland Klassen.
- 2012 Springer Protocolsedited by Qiong Cheng.Screening for cellulases with industrial value and their use in biomass conversion / Julia Jüergensen, Nele Ilmberger, and Wolfgang R. Streit -- Reversal of NAD(P)H cofactor dependence by protein engineering / Sabine Bastian and Frances H. Arnold -- Quantifying plasmid copy number to investigate plasmid dosage effects associated with directed protein evolution / Samuel Million-Weaver [and others] -- High isoprenoid flux Escherichia coli as a host for carotenoids production / Wonchul Suh -- Mutagenic inverted repeats assisted genome engineering (MIRAGE) in Saccharomyces cerevisiae : deletion of gal7 / Nikhil U. Nair and Huimin Zhao -- Creation of new metabolic pathways or improvement of existing metabolic enzymes by in vivo evolution in Escherichia coli / Isabelle Meynial-Salles and Philippe Soucaille -- Bioluminescent reporter genes for promoter discovery / Tina K. Van Dyk -- Recombination-based DNA assembly and mutagenesis methods for metabolic engineering / Xiquan Liang [and others] -- Ethanol-tolerant gene identification in Clostridium thermocellum using pyro-resequencing for metabolic engineering / Shihui Yang, Dawn M. Klingeman, and Steven D. Brown -- Use of proteomic tools in microbial engineering for biofuel production / Shaoming Mao [and others] -- Metabolic engineering of antibiotic-producing Actinomycetes using in vitro transposon mutagenesis / Andrew R. Reeves and J. Mark Weber -- Use FACS sorting in metabolic engineering of Escherichia coli for increased peptide production / Qiong Cheng [and others] -- Using flux balance analysis to guide microbial metabolic engineering / Kathleen A. Curran, Nathan C. Crook, and Hal S. Alper -- Using an advanced microfermentor system for strain screening and fermentation optimization / Dongming Xie -- Rapid strain evaluation using dynamic DO-stat fed-batch fermentation under scale-down conditions / Jun Sun -- Preparation and evaluation of lignocellulosic biomass hydrolysates for growth by ethanologenic yeasts / Ying Zha [and others] -- Engineering whole-cell biosensors with no antibiotic markers for monitoring aromatic compounds in the environment / Aitor de las Heras and Víctor de Lorenzo -- Metabolic engineering for acetate control in large scale fermentation / Yong Tao, Qiong Cheng, and Alexander D. Kopatsis -- Minimization and prevention of phage infections in bioprocesses / Marcin Los.
- 2007 SpringerAjit Varma, Sudhir Chincholkar (eds.).
- 2011 SpringerCharles Hagedorn, Anicet R. Blanch, Valerie J. Harwood, editors.Chapter 1: Overview -- Chapter 2: Performance Criteria -- Chapter 3: Library-dependent Source Tracking Methods -- Chapter 4: Library-Independent Source Tracking Methods -- Chapter 5: Viruses as Tracers of Fecal Contamination -- Chapter 6: Phage Methods -- Chapter 7: Pathogenic Protozoa -- Chapter 8: Chemical-Based Fecal Source Tracking Methods -- Chapter 9: Statistical Approaches for Modeling in Microbial Source Tracking -- Chapter 10: Mitochondrial DNA as Source Tracking Markers of Fecal Contamination -- Chapter 11: Community Analysis-Based Methods -- Chapter 12: Public Perception of and Public Participation in Microbial Source Tracking -- Chapter 13: Use of Microbial Source Tracking in the Legal Arena: Benefits and Challenges -- Chapter 14: Applications of Microbial Source Tracking in the TMDL Process -- Chapter 15: Relating MST Results to Fecal Indicator Bacteria, Pathogens, and Standards -- Chapter 16: Minimizing Microbial Source Tracking at All Costs -- Chapter 17: Environmental Persistence and Naturalization of Fecal Indicator Organisms -- Chapter 18: Agricultural and Rural Watersheds -- Chapter 19: Case Studies of Urban and Suburban Watersheds -- Chapter 20: Beaches and Coastal Environmenta -- Chapter 21: Source tracking in Australia and New Zealand: Case Studies -- Chapter 22: Microbial Source Tracking in China and Developing Nations -- Chapter 23: A National Security Perspective of Microbial Source Tracking -- Chapter 24: Applications of Quantitative Microbial Source Tracking (QMST) and Quantitative Microbial Risk Assessment (QMRA) -- Chapter 25: Food Safety and Implications for Microbial Source Tracking -- Chapter 26: Training Future Scientists: Teaching Microbial Source Tracking (MST) to Undergraduates -- Index.
- 2013 ScienceDirectedited by Colin Harwood, Anil Wipat.Computational intelligence in the design of synthetic microbial genetic systems / Jennifer S. Hallinan -- Constraints in the design of the synthetic bacterial chassis / Antoine Danchin and Agnieszka Sekowska -- Social dimensions of microbial synthetic biology / Jane Calvert, Emma Frow -- Bacillus subtilis: model gram-positive synthetic biology chassis / Colin R. Harwood, Suzanne Pohl, Wendy Smith, Anil Wipat -- Engineering microbial biosensors / Lisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont, Karen Polizzi -- Noise and stochasticity in gene expression: a pathogenic fate determinant / Mikkel Girke Jørgensen, Renske van Raaphorst, Jan-Willem Veening -- Platforms for genetic design automation / Chris J. Myers.
- 2012 Springer Protocolsedited by Ali Navid.pt. I. Sample preparation and identification. -- 1. Flow cytometry in environmental microbiology: a rapid approach for the isolation of single cells for advanced molecular biology analysis / Belinda C. Ferrari, Tristrom J. Winsley, Peter L. Bergquist, and Josie Van Dorst ; 2. Pressure cycling technology in systems biology / Bradford S. Powell, Alexander V. Lazarev, Greta Carlson, Alexander R. Ivanov, and David A. Rozak ; 3. Targeted isolation of proteins from natural microbial communities living in an extreme environment / Steven W. Singer ; 4. Bacterial identification and subtyping using DNA microarray and DNA sequencing / Sufian F. Al-Khaldi, Magdi M. Mossoba, Marc M. Allard, E. Kurt Lienau, and Eric D. Brown -- pt. II. Experimental genomic analysis. -- 5. Genetic manipulation of the obligate chemolithoautotrophic bacterium Thiobacillus denitrificans / Harry R. Beller, Tina C. Legler, and Stacie R. Kane ; 6. Genome-wide mapping of the binding sites of proteins that interact with DNA / Stephen Spiro -- pt. III. Protein and lipid analysis. -- 7. Microbial proteomics using mass spectrometry / Harry B. Hines ; 8. Fourier transform infrared spectroscopy for molecular analysis of microbial cells / Jesús J. Ojeda and Maria Dittrich -- pt. IV. Metabolomic analyses. -- 9. Mass spectrometery-based microbial metabolomics / Edward E.K. Baidoo, Peter I. Benke, and Jay D. Keasling ; 10. Fast sampling of the cellular metabolome / Walter M. Van Gulik, Andre B. Canelas, Hilal Taymaz-Nikeel, Rutger D. Douma, Lodewijk P. de Jonge, and Joseph J. Heijnen -- pt. V. -- 11. Metabolic pathway determination and flux analysis in nonmodel microorganisms through 13C-isotope labeling / Xueyang Feng, Wei-Qin Zhuang, Peter Colletti, and Yinjie J. Tang ; 12. Biolog phenotype microarrays / April Shea, Mark Wolcott, Simon Daefler, and David A. Rozak ; 13. NanoSIP: nanoSIMS applications for microbial biology / Jennifer Pett-Ridge and Peter K. Weber -- pt. VI. Kinetic modeling of cellular processes -- 14. Electrophysiological-metabolic modeling of microbes: applications in fuel cells and environment analysis / Max Fontus and Peter Ortoleva ; 15. Simulating microbial systems: addressing model uncertainty/incompleteness via multiscale and entropy methods / A. Singharoy, H. Joshi, S. Cheluvaraja, Y. Miao, D. Brown, and P. Ortoleva -- pt. VII. -- 16. Bacterial genome annotation / Nicholas Beckloff, Shawn Starkenburg, Tracey Freitas, and Patrick Chain ; 17. LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data / Eleanor C. Saunders, James I. MacRae, Thomas Naderer, Milica Ng, Malcolm J. McConville, and Vladimir A. Likić ; 18. Development of constraint-based system-level models of microbial metabolism / Ali Navid ; 19. Complex network analysis in microbial systems: theory and examples / Zahra Zavareh and Eivind Almaas ; 20. Modeling a minimal cell / Michael L. Shuler, Patricia Foley, and Jordan Atlas.
- 2011 Springer Protocolsedited by Otto Holst.Part I: Bacterial protein toxins -- Detection of bacterial protein toxins by solid phase magnetic immunocapture and mass spectrometry / Gabriella Pocsfalvi and Gitta Schlosser -- Sensitive and rapid detection of cholera toxin-producing Vibrio cholerae using loop-mediated isothermal amplification / Wataru Yamazaki -- Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA / Karine Bagramyan and Markus Kalkum -- Examination of Bacillus anthracis spores by multiparameter flow cytometry / William C. Schumacher [and others] -- A cell-based fluorescent assay to detect the activity of shiga toxin and other toxins that inhibit protein synthesis / Shane Massey, Beatriz Quiñones, and Ken Teter -- Use of a vero cell-based fluorescent assay to assess relative toxicities of shiga toxin 2 subtypes from Escherichia coli / Beatriz Quiñones and Michelle S. Swimley -- Molecular methods: chip assay and quantitative real-time PCR: in detecting hepatotoxic cyanobacteria / Anne Rantala-Ylinen, Hanna Sipari, and Kaarina Sivonen -- Part II: Endotoxins -- Capillary electrophoresis chips for fingerprinting endotoxin chemotypes from whole-cell lysates / Béla Kocsis [and others] -- Isolation of smooth-type lipopolysaccharides to electrophoretic homogeneity / Elder Pupo -- A method for unobtrusive labeling of lipopolysaccharides with quantum dots / Carlos Morales-Betanzos, Maria Gonzalez-Moa, and Sergei A. Svarovsky -- Fluorescence-based methods to assay inhibitors of lipopolysaccharide synthesis / Marcy Hernick -- Micromethods for lipid a isolation and structural characterization / Martine Caroff and Alexey Novikov -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. I. LPS activation with cyanogen bromide / Fernando Battaglini and Diego Pallarola -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. II. LPS activation with a cyanopyridinium agent / Fernando Battaglini and Diego Pallarola -- Part III: Mold fungus toxins -- Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells / Nicholas C. Zitomer and Ronald T. Riley -- Determination of fumonisins B1 and B2 in maize food products by a new analytical method based on high-performance liquid chromatography and fluorimetric detection with post-column derivatization / Marilena Muscarella [and others] -- A confirmatory method for aflatoxin M1 determination in milk based on immunoaffinity cleanup and high-performance liquid chromatography with fluorometric detection / Marilena Muscarella [and others] -- Simultaneous determination of aflatoxins B1, B2, G1, and G2 in foods and feed materials / Marilena Muscarella [and others] -- Highly sensitive PCR-based detection specific to Aspergillus flavus / Amaia González-Salgado -- A rapid enzymatic method for aflatoxin B detection / Danila Moscone, Fabiana Arduini, and Aziz Amine.
- 2014 SpringerJeremy Nuttall, editor.One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
- 2007James D. Kettering, Hansel M. Fletcher, Craig A. Seheult.
- 2010James D. Kettering.
- 2014[edited by] Matthew B. Grisham.High Yield Facts -- Physiology and Molecular Microbiology -- Virology -- Bacteriology -- Rickettsiae, Chlamydiae, and Mycoplasms -- Mycology -- Parasitology -- Immunology.
- 2009 SpringerSteven L. Percival, editor.
- v. 1-, 2006- Springer
- 2014 ScienceDirectSteven L. Percival, Marylynn V. Yates, David W. Williams, Rachel M. Chalmers, Nicholas F. Gray.The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus. Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen. Contains new material on antimicrobial resistance and biofilms. Covers drinking water and both marine and freshwater recreational bathing waters.
- 2010 CRCnetBASEedited by Steven Percival and Keith Cutting.An introduction to the world of microbiology and biofilmology / Steven L. Percival, John G. Thomas, and David Williams -- Human skin and microbial flora / Rose A. Cooper and Steven L. Percival -- An introduction to wounds / Michel H.E. Hermans and Terry Treadwell -- Burn wound management / Michel H.E. Hermans -- Cell biology of normal and impaired healing / Keith Moore -- The microbiology of wounds / Steven L. Percival and Scott E. Dowd -- Types of wounds and infections / Randall D. Wolcott ... [et al.] -- Biofilms and significance to wound healing / Keith F. Cutting ... [et al.] -- Wounds, enzymes, and proteases / Steven L. Percival and Christine A. Cochrane -- Wound healing immunology and biofilms / Emma J. Woods ... [et al.] -- Antimicrobial interventions for wounds / Steven L. Percival, Rose A. Cooper, and Benjamin A. Lipsky -- Wound dressings and other topical treatment modalities in bioburden control / Richard White -- Factors affecting the healing of chronic wounds : an iconoclastic view / Marissa J. Carter and Caroline E. Fife.
- 2010S. James Booth.Basic bacteriology -- Genetics -- Antimicrobial agents -- General medical microbiology -- Gram-positive cocci -- Gram-negative cocci -- Gram-positive and acid-fast bacilli -- Gram-negative bacilli -- Anaerobes -- Spirochetes -- Atypical pathogenic bacteria : mycoplasma, rickettsia, ehrlichia, anaplasma, chlamydia, and chlamydophila -- Virology -- Mycology -- Parasitology -- Random pearls.
- v. 1-2, 2008.Todd A. Swanson, Sandra I. Kim, Olga E. Flomin.v. 1. Virology, immunology, parasitology, mycology -- v. 2. Bacteriology.
- 2016 SpringerAndreas Schwiertz, editor.Preface -- Chapter 1. Microbiota: what does it mean (historic considerations- Schwiertz et. al) -- Chapter 2. Studying the human microbiota -- Alan Walker -- Chapter 3. The gut microbiota and their metabolites: potential implications for the host epigenome -- Mona Mischke and Torsten Plösch -- Chapter 4. The Oral Microbiota -- Nicole B. Arweiler, Lutz Netuschil -- Chapter 5. Skin Microbiota -- Markus Egert and Rainer Simmering -- Chapter 6. Vaginal Microbiota -- Werner Mendling -- Chapter 7. Gastrointestinal Microbiota -- Hermie J.M. Harmsen and Marcus. C. de Goffau -- Chapter 8. How to manipulate the Microbiota by Probiotics -- Verena Grimm and Christian U. Riedel -- Chapter 9. How to manipulate the Microbiota by Prebiotics -- Petra Louis, Harry J. Flint and Catherine Michel. Chapter 10. Microbiota transplantation -- Susana Fuentes, Ph.D. and Willem M. de Vos, Prof. Ph.D -- Index. .Also available: Print – 2016
- Microorganisms in home and indoor work environments : diversity, health impacts, investigation and control. 2nd ed.2011 CRCnetBASEedited by Brian Flannigan, Robert A. Samson, J. David Miller.Machine generated contents note: ch. 1 Microorganisms in air -- 1.1.Microorganisms in outdoor air / B. Flannigan -- 1.2.Microorganisms in indoor air / B. Flannigan -- 1.3.Pollen in indoor air / A. Rantio-Lehtimaki -- ch. 2 Microorganisms in homes and work environments -- 2.1.Microbial growth in indoor environments / J.D. Miller -- 2.2.Bacteria and other bioaerosols in industrial workplaces / J.R.M. Swan -- 2.3.Remediation and control of microbial growth in problem buildings / P.R. Morey -- ch. 3 Airborne microorganisms and disease -- 3.1.Allergenic microorganisms and hypersensitivity / J.H. Day -- 3.2.Occupational respiratory disease: hypersensitivity pneumonitis and other forms of interstitial lung disease / B. Flannigan -- 3.3.Respiratory tract infections caused by indoor fungi / R.C. Summerbell -- ch. 4 Microbiological investigation of indoor environments -- 4.1.Mycological investigations of indoor environments / J.D. Miller -- 4.2.Molecular methods for bioaerosol characterization / J.A. Scott -- 4.3.Isolation and identification of fungi / J. Houbraken -- 4.4.Analysis of microbial volatile organic compounds / T.J. Ryan -- 4.5.Analysis for toxins and inflammatory compounds / J.D. Miller -- 4.6.Interpreting sampling data in investigations of indoor environments: selected case studies / P.R. Morey -- ch. 5 Common and important species of Actinobacteria and fungi in indoor environments -- Common and important species of fungi and actinomycetes in indoor environments / J.D. Miller -- Descriptions and illustrations of common fungi and actinomycetes.
- 2013 ClinicalKeyRichard V. Goering, Hazel M. Dockrell, Mark Zuckerman, Peter L. Chiodini, Ivan M. Roitt.Using a clinically relevant, systems-based approach, this medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Richard Goering makes this complex subject simple to understand and remember. 150 multiple choice review questions. "Pathogen Parade" and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way. Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
- 2013Lena Pernas.Protozoan and prokaryotic pathogens are able to recruit mitochondria to the vacuoles in which they grow (Friis, 1972; Horwitz, 1983), in mammalian and protozoan cells. The functional significance of the recruitment and association of this phenomenon in Toxoplasma-infected cells has been a subject of speculation since it was first described in the early 1970s (Jones et al., 1972). Previous work has proposed Toxoplasma gondii rhoptry protein 2 (Sinai and Joiner, 2001) as the physical link that tethers host mitochondria to the parasitophorous vacuole and conventional wisdom since has suggested that mitochondrial recruitment served a nutritional function supplementary to the parasite. A recent analysis of the ROP2 structure raised questions about this model ((Labesse et al., 2009; Reese and Boothroyd, 2009). Chapter II describes the effect of deleting ROP2 on mitochondrial association while Chapter III describes the identification of a novel mediator of mitochondrial association, Mitochondrial association factor I (MAF1) and experiments that attempt to answer the role of this remarkable phenomenon in the host-pathogen interaction. Chapter IV describes a project undertaken to determine the impact of Toxoplasma gondii infection in humans acutely and chronically infected in different geographical regions. Chapter V concludes with a discussion of future directions for further characterization of host mitochondrial association in the host response to microbial infection.
- 2012Erica Machlin Cox.Hepatitis C virus (HCV) is a global health problem, infecting approximately 2% of the world's population. The virus is hepatotropic, replicating in liver cells, and its only known hosts are humans and chimpanzees. HCV is an unusual virus in that it requires the liver-specific host microRNA (miRNA) miR-122 for HCV RNA accumulation. Though the precise mechanism by which miR-122 upregulates HCV RNA is still under investigation, it is known that miR-122 must bind to two adjacent sites in the 5' end of the HCV genome. In this dissertation, a stepwise mutational analysis of the entire sequence of miR-122 was performed to identify residues important for HCV RNA accumulation. All mutant miRNAs were tested in canonical miRNA reporter assays and in HCV RNA accumulation assays. The identities of two nucleotides within miR-122, at positions 15 and 16, were shown to be dispensable for canonical miRNA and siRNA activity but required for HCV RNA accumulation. Compensatory mutations in the HCV genome upstream of the original binding sites uncovered supplementary binding sites for nucleotides 15 and 16 of miR-122. This analysis led to a new model for miR-122-HCV RNA interactions. To further define the requirements of HCV for miR-122, we investigated whether the predecessor of mature miR-122, a long hairpin precursor designated pre-miR-122, was also able to mediate HCV RNA accumulation. The function of pre-miR-122 was tested in miRNA, siRNA, and HCV RNA accumulation assays. Inhibition of pre-miR-122 processing was achieved by substituting deoxyribonucleotides into the loop of pre-miR-122 to prevent Dicer-mediated cleavage. Full-length pre-miR-122 was demonstrated to be functional in miRNA and siRNA assays and to be sufficient for HCV RNA accumulation. Pre-miR-122 also required traditional components of the RNA-induced silencing complex (RISC) for activity. Taken together, this research has uncovered novel requirements of miR-122 for HCV RNA accumulation. Components shown to be dispensable for canonical miRNA interactions were necessary for this unusual microRNA-target RNA interaction. Uncovering hepatitis C virus's stringent requirements for the mature and precursor forms of miR-122 will pave the way for new antiviral therapies targeting a host factor.
- 2014 SpringerFalk Nimmerjahn, editor.This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
- AccessMedicine Lange Case files — Fungal biofilms and related infections : advances in microbiology, infectious diseases and public health. Volume 3 (100)
- Fungal diagnostics : methods and protocols — Molecular and cellular mechanisms of antibody activity (100)
- Molecular cellular microbiology — Toxoplasma gondii co-opts host immune signaling by secretion of a polymorphic tyrosine kinase, ROP16 (100)
- TT viruses : the still elusive human pathogens — Yeast systems biology : methods and protocols (18)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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