Books by Subject
- Advanced protocols in oxidative stress. I 2008Springer ProtocolsVol. 1. Novel designed probes for the characterization of oxidative stress in biological fluids, cells, and tissues / Jacob Vaya -- A rapid and selective mass spectrometric method for the identification of nitrated proteins / Angela Amoresano ... [et al.] -- An easy and reliable automated method to estimate oxidative stress in the clinical setting / Cristina Vassalle -- Correlative transmission microscopy : cytochemical localization and immunocytochemical localization in studies of oxidative and nitrosative stress / E. Ann Ellis -- Detection of specifically oxidized apolipoproteins in oxidized HDL / Xiao Suo Wang and Roland Stocker -- High performance liquid chromatography/electron spin resonance/mass spectrometry analyses of lipid-derived radicals / Hideo Iwahashi -- EPR spin-trapping and nano LC MS/MS techniques for DEPMPO/OOH and immunospin-trapping with anti-DMPO antibody in mitochondrial electron transfer system / Yeong-Renn Chen -- Determination of high mitochondrial membrane potential in spermatozoa loaded with the mitochondrial probe 5,5',6,6'-tetrachloro-1,1',3,3'-tetraethylbenzimidazolyl-carbocyanine iodide (JC-1) and for using fluorescence-activated flow cytometry / H. David Guthrie and Glenn R. Welch -- 2,2,6,6-tetramethylpiperidin-1-oxyl probes for evaluating oxidative stress on the cell membrane and mitochondria / Hidehiko Nakagawa and Naoki Miyata -- Zymographical techniques for detection of matrix metalloproteinases / Shinichi Iwai ... [et al.] -- The use of in vivo microdialysis techniques to detect extracellular ROS in resting and contracting skeletal muscle / Graeme L. Close and Malcolm J. Jackson -- Cell-free antibody capture method for analysis of detergent-resistant membrane rafts / Anil Bamezai and Colleen Kennedy. Determination of acrolein by high-voltage capillary electrophoresis from oxidized fatty acids / Rafael Medina-Navarro. Cupric ion reducing antioxidant capacity assay for food antioxidants : vitamins, polyphenolics, and flavonoids in food extracts / Reşat Apak ... [et al.] -- Redox property of ribonucleotide reductase small subunit M2 and p53R2 / Xiyong Liu, Lijun Xue, and Yun Yen -- Antioxidant QSAR modeling as exemplified on polyphenols / Bono Lučić, Dragan Amić, and Nenad Trinajstić -- Immunohistochemical staining of cyclooxygenases with monoclonal antibodies / Ghassan M. Saed -- Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue / Kathryn A. Lindl and Kellly L. Jordan-Sciutto -- Determination of oxidized and reduced CoQ10 and CoQ9 in human plasma/serum using HPLC-ECD / Ian N. Acworth, Paul A. Ullucci, and Pul H. Gamache. Paraoxonases (PON1, PON2, PON3) analysis in vitro and in vivo in relation to cardiovascular diseases / Michael Aviram and Mira Rosenblat -- Preparation, characterization, and use of antioxidant-liposomes / Hongsong Yang ... [et al.] -- Antioxidant activity of biotransformed sex hormones facilitated by Bacillus stearothermophilus / Mohammad Afzal, Sameera Al-Awadi, and Sosamma Oommen -- Biolistic mediated production of transgenic oil palm / Ghulam Kadir Ahmad Parveez -- Preparation of a multi-antioxidant formulation / John A. Mulnix and Brook E. Stoddard -- A functional genomics approach to identify and characterize oxidation resistance genes / Michael R. Volkert, Jen-Yeu Wang, and Nathan A. Elliott -- Genome-wide overexpression screen for activators of antioxidant gene transcription / Hendrik Luesch and Yanxia Liu -- Method for conducting microarray study of oxidative stress induced gene expression / Sita Subbaram, Juan A. Melendez, and Sridar V. Chittur -- A systems approach demonstrating sphingolipid-dependent transcription in stress responses / Alan J. Wilder and L. Ashley Cowart -- Bioluminescence : imaging modality for in vitro and in vivo gene expression / Ruxana T. Sadikot and Timothy S. Blackwell -- Reactive oxygen species and upregulation of NADPH oxidases in mechanotransduction of embryonic stem cells / Heinrich Sauer ... [et al.] -- Pooling data when analyzing biomarkers subject to a limit of detection / Leslie Rosenthal and Enrique Schisterman.
- Overview, The IOM Report, and Integrated Marketing Communications -- Introduction: Childhood Obesity: Media, Advertising, Community, and Advocacy -- Progress on Public Policy: The Aftermath of the 2005 Institute of Medicine Report on Food Marketing and the Diets of Children and Youth -- Integrated Marketing Communications and Power Imbalance: The Strategic Nature of Marketing to Children and Adolescents by Food and Beverage Companies -- Legal, Ethical, and Policy Implications of Advertising -- The Role of Ethics in Food and Beverage Marketing to Children -- The New First Amendment and Its Implications for Combating Obesity Through Regulation of Advertising -- Self-regulation as a Tool for Promoting Healthier Children's Diets: Can CARU and the CFBAI Do More? -- Monitoring Food Company Marketing to Children to Spotlight Best and Worst Practices -- Measuring the Impact of Advertising Effects -- Children's Exposure to Food and Beverage Advertising on Television: Tracking Calories and Nutritional Content by Company Membership in Self-regulation -- The Role of Advertising on Attitudes and Consumption of Food and Beverage Products -- The Digital Food Marketing Landscape: Challenges for Researchers -- A Multi-Method Study to Understand How Youth Perceive and Evaluate Food and Beverage Advertisements -- A Global Perspective of Food Marketing and the Role of Place -- Adolescents' Response to Food Marketing in Delhi, India -- The Role of Schools in Food and Beverage Marketing: Significance, Challenges, Next Steps -- Outdoor Food and Beverage Advertising: A Saturated Environment -- Exploring Marketing Targeted at Youth in Food Stores -- Racial/Ethnic Minorities and Community Empowerment -- Understanding Community Perspectives: A Step Towards Achieving Food Marketing Equity -- Latino Youth and Obesity: Communication/Media Influence on Marketing -- Targeted Marketing of Junk Food to Ethnic Minority Youth: Fighting Back with Legal Advocacy and Community Engagement -- Communicating About Physical Activity -- Physical Activity, Media, and Marketing: Advances in Communications and Media Marketing -- Communities Leveraging the Assets of a National Social Marketing Campaign: Experiences with VERB[TM]. It's What You Do! -- Development and Release of the 2008 Physical Activity Guidelines for Americans: Children and Adolescents -- Thinking Outside the Box: Finding Solutions to Reverse Childhood Obesity -- Voluntary Health Organizations and Nonprofit Advocacy Organizations Play Critical Roles in Making Community Norms More Supportive of Healthier Eating and Increased Physical Activity -- Childhood Obesity and Exergames: Assessments and Experiences from Singapore -- Leveraging Industry Efforts to Fight Childhood Obesity: A Multi-Sectored Approach to Communications.
- Alkaptonuria and ochronosis 2015SpringerThis book comprehensively describes alkaptonuria and ochronosis. Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. This is complemented by the latest data on therapy and experimental models of alkaptonuria, and supported by several case reports. Numerous pictures and radiological images document the clinical symptoms, giving the reader a solid understanding of the disease. On the basis of the editor?s and authors? own extensive observations, the book offers an analysis of protein metabolism and aromatic amino acids in the context of alkaptonuria. Written by international experts in the field, the book offers a valuable reference guide for healthcare professionals working in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.
- Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.
- Appetite control 2012SpringerThe volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control.
- The Metabolic Syndrome -- Epidemiology of the Metabolic Syndrome and Risk for Cardiovascular Disease and Diabetes -- The Metabolic Syndrome and Atherogenesis -- Triglyceride-Rich Lipoproteins -- High-Density Lipoprotein Metabolism -- Newer Coronary Risk Factors -- Dietary Effects on Cardiovascular Risk Factors -- Strategies for Treating Abnormal Lipid Profiles with Drugs -- Ethnic Differences in the Metabolic Syndrome -- Obesity Management -- Diabetes Mellitus and Cardiovascular Disease -- Gender Differences in Coronary Risk Factors and Risk Interventions.
- Atlas of metabolic diseases. 3rd ed. 2012ebrary, Limited to 3 simultaneous usersOrganic acidemias -- Disorders of amino acid metabolism -- Hyperammonemia and disorders of the urea cycle -- Disorders of fatty acid oxidation -- The lactic acidemias and mitochonrdial disease -- Disorders of carbohydrate metabolism -- Perioxisomal disorders -- Disorders of purine metabolism -- Disorders of transport and mineral metabolism -- Mucopolysaccharidoses -- Mucolipidoses -- Disorders of cholesterol and neutral lipid metabolism -- Lipid storage disorders -- Miscellaneous.
- Bariatric and metabolic surgery 2014SpringerBariatric and metabolic surgery is recognized to be an important and effective option for the treatment of severe obesity and the various associated conditions and diseases, such as type II diabetes, hypertension, cardiovascular dysfunction, dyslipidemia, and obstructive sleep apnea. Despite its established value, however, there is scope for further improvement in safety and in the quality of the surgical techniques, and calls have therefore been made for the establishment of standard techniques and procedures. This book accordingly presents state of the art knowledge on bariatric and metabolic surgery with the aim of facilitating the sharing and exchange of knowledge, documenting effective techniques, and enhancing safety and outcomes. All technical aspects are covered in detail, and the text is complemented by many helpful illustrations. A further key feature is the provision of accompanying surgical videos, which will be of value to both novice and experienced surgeons. This textbook will be a great asset in clinical practice for all who are involved or interested in bariatric and metabolic surgery.
- Bioenergetics energy conservation and conversion Günter Schäfer, Harvey S. Penefsky (eds.). 2008SpringerDiversity of the heme-copper superfamily in Archaea: insights from genomics and structural modeling / James Hemp, Robert B. Gennis -- Structure of Photosystems I and II / Petra Fromme, Ingo Grotjohann -- Microbial rhodopsins: scaffolds for ion pumps, channels, and sensors / Johann P. Klare, Igor Chizhov, Martin Engelhard -- Life close to the thermodynamic limit: how methanogenic Archaea conserve energy / Uwe Deppenmeier, Volker Müller -- ATP synthesis by decarboxylation phosphorylation / Peter Dimroth, Christoph von Ballmoos -- The three families of respiratory NADH dehydrogenases / Stefan Kerscher ... [et al.] -- Hydrogenases and H+-reduction in primary energy conservation / Paulette M. Vignais -- A structural perspective on mechanism and function of the cytochrome bc1 complex / Carola Hunte ... [et al.] -- Regulatory mechanisms of proton-translocating FoF1-ATP synthase / Boris A Feniouk, Masasuke Yoshida.
- Bioenergetics. Fourth edition [4th ed.]. 2013ScienceDirectExtensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins.Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging.Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.
- Inflammation biomarkers and cardiometabolic risk -- Cardiovascular disease -- Diabetes mellitus and metabolic syndrome -- Ischemic stroke -- Chronic kidney disease -- Immune-mediated inflammatory rheumatic diseases -- Cardiometabolic risk, inflammation and neurodegenerative disorders.
- Biotransport-- principles and applications 2011SpringerPart I. Fundamentals of How People Learn (HPL) -- Introduction to HPL Methodology -- Part II. Fundamental Concepts in Biotransport -- Fundamental Concepts in Biotransport -- Modeling and Solving Biotransport Problems -- Part III. Biofluid Transport -- Rheology of Biological Fluids -- Macroscopic Approach for Biofluid Transport -- Shell Balance Approach for One Dimensional Biofluid Transport -- General Microscopic Approach for Biofluid Transport -- Part IV. Bioheat Transport -- Heat Transfer Fundamentals -- Macroscopic Approach to Bioheat Transport -- Shell Balance Approach for 1-D Bioheat Transport -- General Microscopic Approach for Bioheat Transport -- Section V. Biological Mass Transport -- Mass Transfer Fundamentals -- Macroscopic Approach to Biomass Transport -- Shell Balance Approach for 1-D Biomass Transport -- General Microscopic Approach for Biomass Transport.
- Body metabolism and exercise 2015SpringerThe dynamics of body metabolism are changed in the disease process and interact with physical activity. The alteration of metabolism and its consequences raise the need for simple and reliable methods for assessment of body composition. The chapters aim to investigate various interacting components converging on metabolic changes in lung and muscle tissues taking into consideration the drug effects. The effects of exercise and nutritional status are dealt with at a great extent.
- Bone and mineral manual a practical guide. 2nd ed. 2005ScienceDirectIndications for bone mass measurement / Dorothy A. Nelson, Michael Kleerekoper -- A practical guide to bone densitometry / Dorothy A. Nelson, Michael Kleerekoper -- Laboratory analyses useful in the diagnosis of bone and calcium metabolic disorders / Hunter Heath, III -- Biochemical markers of bone remodeling / Michael Kleerekoper -- Skeletal imaging: radiographs, computed tomography (CT), and magnetic resonance imaging (MRI) / Harry K. Genant -- Scintigraphy / Ignac Fogelman -- Hypocalcemia and hypercalcemia in neonates / Winston Koo -- Preterm infants with fractures / Winston Koo -- Rickets / John M. Pettifor -- Osteogenesis imperfecta / Jay R. Shapiro, Paul Sponseller -- Juvenile osteoporosis / Craig B. Langman -- Fibrous dysplasia / Frederick S. Kaplan -- Optimizing peak bone mass / John M. Pettifor -- Bone disorders associated with primary or secondary amenorrhea / Michelle P. Warren, Sari Halpert -- Nephrolithiasis / Murray J. Favus -- Acute spinal cord injury and traumatic brain injury / Albert C. Clairmont, Velimir Matkovic -- Reflex sympathetic dystrophy / Albert C. Clairmont, Velimir Matkovic -- Evaluation of the patient with low bone density / Marjorie Luckey -- Calcium and vitamin D / Bess Dawson-Hughes -- Pharmacologic therapy / Nelson Watts, Michael McClung -- Nonpharmacologic prevention and management of falls and fractures / Susan Greenspan -- Osteoporosis in men / Eric Orwoll -- Steroid-induced osteoporosis / Barbara P. Lukert -- Organ transplantation / Elizabeth Shane -- Paget disease of bone / Ethel S. Siris -- Renal bone diseases / Paul D. Miller, Edgar V. Lerma -- Metastatic bone disease / Socrates E. Papapoulos -- Osteomalacia / Carolyn Becker -- High bone mass / Michael P. Whyte -- Hypercalcemia -- Line Vautour, David Goltzman -- Primary hyperparathyroidism / John P. Bilezikian -- Hypocalcemia / Frederick R. Singer -- Phosphorous and magnesium / S. Abbas Raza, Marc K. Drezner -- Principles of patient and family education and support / Betsy McClung -- Resources for education and support / Betsy McClung.
- Bone-metabolic functions and modulators 2012SpringerParathyroid Hormone and Parathyroid-Hormone-Related Protein: Normal Function, Diseases, and Emerging Therapeutics / Ling Qin and Nicola C. Partridge -- Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics / René St-Arnaud and Marie B. Demay -- Gonadal Hormones, Diseases, and Emerging Therapeutics / Faryal S. Mirza, Liam Zakko and Pamela Taxel -- Thyroid and Thyroid Hormone: Normal Function, Diseases, Disorders, Emerging Therapeutics / Paula H. Stern -- Pituitary Hormones and the Pathophysiology of Osteoporosis / Manasi Agrawal, Shitij Arora, Graziana Colaianni, Li Sun and Jameel Z. Iqbal, [et al.] -- Calcitonin: Its Physiological Role and Emerging Therapeutics / Jillian Cornish, Dorit Naot and T. John Martin -- Glucocorticoids, Inflammation, and Bone / Kong Wah Ng and T. John Martin -- Diseases of Energy and Lipid Metabolism and Bone: Emerging Therapeutics / Sumithra K. Urs and Clifford J. Rosen -- Diseases of Mineral Metabolism and Bone: Emerging Therapeutics for Postmenopausal Osteoporosiss / Paul D. Miller -- Renal Diseases and Bone: Emerging Therapeutics / Nancy S. Krieger and David A. Bushinsky -- Wasting Diseases and Metabolic Impact on Bone: Emerging Therapeutics and Treatment Options / Linda A. DiMeglio -- Paget's Disease of Bone: Pathogenesis and Treatment / Frederick R. Singer and G. David Roodman -- Bone Loss in Space Flight and Countermeasures /; Adrian D. LeBlanc, Elisabeth R. Spector and Victor S. Schneider --; Osteoimmunology: Relation to Disease and Therapy /; M. Neale Weitzmann and Roberto Pacifici -- Bone and the Ear / Kathleen C. Horner -- Bone and the cAMP Signaling Pathway: Emerging Therapeutics / Paul M. Epstein -- Nervous System Diseases, Disorders, and Bone: Emerging Therapeutics and Treatment Options / Mary F. Barbe and Steven N. Popoff.
- Section 1. Exposure and closure of the abdomen -- section 2. Primarily malabsorptive procedures -- section 3. Malabsorptive/restrictive procedures : gastric bypass -- section 4. Restrictive procedures -- section 5. Other and investigative procedures -- section 6. Revisional surgery.
- Cachexia and wasting a modern approach 2006Springer
- Calcium homeostasis and signaling in aging. 1st ed. 2002.ScienceDirect
- Annexinopathies / M.J. Hayes ... [et al.] -- Calpains and human disease / I. Bertipaglia and E. Carafoli -- Gelsolin and diseases / L. Spinardi and W. Witke -- Guanylate cyclase-activating proteins and retina disease / W. Baehr and K. Palczewski -- Pathologies involving the S100 proteins and rage / C.W. Heizmann ... [et al.] -- The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics / E.M. Brown -- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease / J. Colomer and A.R. Means -- Calcium channelopathies: Voltage-gated calcium channels / P.J. Adams and T.P. Snutch -- TRP channels in disease / S.E. Jordt and B.E. Ehrlich -- Diseases associated with altered ryanodine receptor activity / W.J. Durham ... [et al.] -- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease / I. Bezprozvanny -- SERCA pumps and human diseases / A. Hovnanian -- The plasma membrane calcium ATPase and disease / B.L. Tempel and D.J. Shilling -- Diseases involving the Golgi calcium pump / J. Vanoevelen ... [et al.] -- Calcium signalling and cancer cell growth / T. Capiod ... [et al.] -- Calcium misregulation and the pathogenesis of muscular dystrophy / F.W. Hopf ... [et al.] -- Calcium and cell death / A. Verkhratsky -- Calcium and cell death: The mitochondrial connection / P. Bernardi and A. Rasola -- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models / K.N. Green ... [et al.] -- Calcium and cardiomyopathies / E.G. Kranias and D.M. Bers -- Calcium signalling and calcium transport in bone disease / H.C. Blair ... [et al.].
- Cardiac energy metabolism in health and disease 2014SpringerPart I. Control of Energy Metabolism -- A Primer on Carbohydrate Metabolism in the Heart / Heinrich Taegtmeyer -- Lipoproteins: A Source of Cardiac Lipids / Konstantinos Drosatos and Ira J. Goldberg -- Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart / Andrea Wan and Brian Rodrigues -- Control of Myocardial Fatty Acid Uptake / Jan F. C. Glatz and Joost J. F. P. Luiken -- Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes / Gary D. Lopaschuk -- Transcriptional Control of Mitochondrial Biogenesis and Maturation / Rick B. Vega , Teresa C. Leone , and Daniel P. Kelly -- Relationship Between Substrate Metabolism and Cardiac Efficiency / Ellen Aasum -- Acetylation in the Control of Mitochondrial Metabolism and Integrity / Michael N. Sack -- Part II. Alteration in Energy Metabolism -- Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes / Vijay Sharma and John H. McNeill -- The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart / Craig A. Lygate and Stefan Neubauer -- Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure / Stephen C. Kolwicz and Rong Tian -- Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury / Vijayan Elimban , Paramjit S. Tappia , and Naranjan S. Dhalla -- The Role of AMPK in the Control of Cardiac Hypertrophy / Nikole J. Byrne, Miranda M. Sung, and Jason R. B. Dyck -- The Role of Incomplete Fatty Acid β-Oxidation in the Development of Cardiac Insulin Resistance / John R. Ussher -- Part III. Optimization of Energy Metabolism -- Metabolic Therapy for the Ischemic Heart / Giacinta Guarini , Alda Huqi , and Mario Marzilli -- Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients / Rui Yan , Jin Wei , and Dengfeng Gao -- Cardiac Metabolic Protection for the Newborn Heart / J. Carter Ralphe and Thomas D. Scholz -- Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease / Michael A. Portman and Aaron K. Olson.
- Cardiovascular issues in endocrinology 2014KargerTestosterone and cardiovascular risk in men / Kelly, D.M., Jones, T.H. -- Hormone therapy and venous thromboembolism among postmenopausal women / Scarabin, P.-Y. -- Cardiovascular and metabolic impact of glucocorticoid replacement therapy / Johannsson, G., Ragnarsson, O. -- Cardiovascular disease and thyroid function / Faber, J., Selmer, C. -- Hormonal alterations in heart failure : anabolic impairment in chronic heart failure -- diagnostic, prognostic and therapeutic issues / Arcopinto, M., Cittadini, A. -- Genetics of primary aldosteronism / Funder, J.W. -- Adipose tissue dysfunction and inflammation in cardiovascular disease / Wronkowitz, N., Romacho, T., Sell, H., Eckel, J. -- Potential peptides in atherosclerosis therapy / Marleau, S., Mellal, K., Huynh, D.N., Ong, H. -- Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging / Higashi, Y., Quevedo, H.C., Tiwari, S., Sukhanov, S., Shai, S.-Y., Anwar, A., Delafontaine, P. -- Ghrelin and the cardiovascular system / Tokudome, T., Kishimoto, I., Miyazato, M., Kangawa, K. -- Natriuretic peptide system and the heart / del Ry, S., Cabiati, M., Clerico, A. -- Beyond glycemic control : cardiovascular effects of incretin-based therapies / Angeli, F.S., Shannon, R.P.
- Case studies in physiology and nutrition 2010CRCnetBASE"Today's knowledge of human health demands a multidisciplinary understanding of medically related sciences, and Case Studies in the Physiology of Nutrition answers the call. Dedicated to the integration of nutrition science with physiology, this text cohesively incorporates descriptions of human problems in order to stimulate students' critical thinking about how the body integrates various physiological factors to maintain homeostasis. This textbook uses short story-type case studies about fictional individuals who have health problems in order to address a range of issues in an approachable manner. The studies vary in difficulty, with some being straightforward with very simple answers, while others require in-depth thinking and literature research to solve. Each study presents patient background, symptoms, clinical finding, and questions to ponder. Upon qualifying course adoption, this book also includes a valuable instructor's manual, which provides solutions to exercises, problem analysis, and resolution to each case study."--Publisher's description.
- 1. Human Evolution and Physical Exercise: The Concept of Being "Born to Run" / Livio Luzi -- 2. Cell Morphology and Function: The Specificities of Muscle Cells / Anna Maestroni -- 3. The Cell Membrane of the Contractile Unit / Gianpaolo Zerbini -- 4. Gene Polymorphisms and Athletic Performance / Ileana Terruzzi -- 5. Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise / Stefano Benedini -- 6. Mitochondrial and Non-mitochondrial Studies of ATP Synthesis / Roberto Codella -- 7. Excessive Nutrients and Regional Energy Metabolism / Gianluca Perseghin -- 8. Muscle Biopsy To Investigate Mitochondrial Turnover / Rocco Barazzoni -- 9. Introduction to the Tracer-Based Study of Metabolism In Vivo / Andrea Caumo and Livio Luzi -- 10. Physical Activity and Inflammation / Raffaele Di Fenza and Paolo Fiorina -- 11. The HPA Axis and the Regulation of Energy Balance / Francesca Frigerio -- 12. Physical Exercise in Obesity and Anorexia Nervosa / Alberto Battezzati and Simona Bertoli -- 13. Physical Exercise and Transplantation / Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi -- 14. The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise / Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.
- Childhood obesity prevalence, pathophysiology, and prevention. First edition. [1st ed.] 2014CRCnetBASEPart I. Genetic and environmental factors -- part II. Adverse health consequences -- part III. Prevention and treatment.
- Clinical aspects and laboratory iron metabolism, anemias : concepts in the anemias of malignancies and renal and rheumatoid diseases. 6th, rev. and updated ed. 2011Springer
- Introduction: medical management of obesity -- Epidemiology of childhood obesity -- Pathophysiology of obesity -- Obesity in the context of child and adolescent development -- Evaluation of the obese child -- Respiratory complications -- Cardiovascular complications -- Insulin resistance, the metabolic syndrome, and type 2 diabetes -- Orthopedic complications -- Gastrointestinal complications -- Renal complications -- Neurologic complications -- Mental health issues -- Specific genetic causes of obesity -- Acute obesity-related emergencies -- Practice management strategies for obesity.
- The field of clinical nutrition as a whole seeks to consider the nutrition of patients within the healthcare system, paying attention to the interactions between diet, nutrition, and disease. To that end, this book discusses nutrition as both a contributing and managing factor in relation to diseases such as obesity and diabetes. It also presents malnutrition as a contributing factor to such diseases and considers the efficacy of micronutrient supplementation. It ends by looking at some of the recent developments and future trends in the field of clinical nutrition.
- Clinical trials in osteoporosis. 2nd ed. 2007Springer
- Clinician's guide to the treatment of obesity 2015Springer1. The disease of obesity -- 2. The health burden of obesity -- 3. Psychosocial morbidity and the effect of weight loss -- 4. Dietary and lifestyle strategies for weight loss -- 5. Physical activity and writing an exercise prescription -- 6. The doctor's tool kit: pharmacolotherapy for the patient with obesity -- 7. Roux-en-Y gastric bypass: procedure and outcomes --- 8. Sleeve gastrectomy: procedure and outcomes -- 9. Laparoscopic adjustable gastric banding: procedure and outcomes -- 10. Perioperative care of the surgical patient -- 11. Surgical complications of weight loss surgery -- Index.
- An introduction to fasting, starvation, and food limitation / Marshall D. McCue -- A history of modern research into fasting, starvation, and inanition / Jean-Hervé Lignot and Yvon LeMaho -- Starvation in rotifers : physiology in an ecological context / Kevin L. Kirk -- Drosophila as a model for starvation : evolution, physiology, and genetics / Alen G. Gibbs and Lauren A. Reynolds -- Metabolic transitions during feast and famine in spiders / Johannes Overgaard and Tobias Wang -- Adaptation of the physiological, endocrine, and digestive system functions to prolonged food deprivation in fish / Nadav Bar and Helene Volkoff -- Starvation in subterranean species versus surface-dwelling species : crustaceans, fish, and salamanders / Frédéric Hervant -- Physiological responses to starvation in snakes : low energy specialists / Marshall D. McCue, Harvey B. Lillywhite, and Steven J. Beaupre -- Cardiovascular circuits and digestive function of intermittent-feeding sauropsids / Rike Campen and Matthias Starck -- Thermoregulatory adaptations to starvation in birds / Esa Hohtola -- Fasting in birds : general patterns and the special case of endurance flight / Susanne Jenni-Eiermann and Lukas Jenni -- Tissue-specific mass changes during fasting : the protein turnover hypothesis / Ulf Bauchinger and Scott R. McWilliams -- Seasonal changes in body mass and energy balance in wild small mammals / Xueying Zhang, Xinyu Liu, and Dehua Wang -- Changes in form and function of the gastrointestinal tract during starvation : from pythons to rats / Jehan-Hervé Lignot -- Changes in fatty acid composition during starvation in vertebrates : mechanisms and questions / Edwin R. Price and Teresa G. Valencak -- Physiological responses to fasting in bats / Miriam Ben-Hamo, Agustí Muñoz-Garcia, and Berry Pinshow -- Muscle protein and strength retention by bears during winter fasting and starvation / Hank Harlow -- Seasonal starvation in northern white-tailed deer / Duane E. Ullrey -- Fasting physiology of the pinnipeds : the challenges of fasting while maintaining high energy expenditure and nutrient delivery for lactation / Cory D. Champagne ... [et al.] -- The use and application of stable isotope analysis to the study of starvation, fasting, and nutritional stress in animals / Kent A. Hatch -- Fearing the danger point : the study and treatment of human starvation in the United Kingdom and India, c. 1880-1974 / Kevin Grant -- Quantitative physiology of human starvation : adaptations of energy expenditure, macronutrient metabolism, and body composition / Kevin D. Hall -- Alternate day fasting : effects on body weight and chronic disease risk in humans and animals / Krista A. Varady -- Horizons in starvation research/ Marshall D. McCue.
- Controversies in obesity 2014SpringerObesity is a relatively new and controversial field of medicine. Some of the controversies surrounding obesity can be dismissed as myths, others reveal the lack of consensus and comprehensive knowledge which exist in obesity and its complex relationship with diabetes and other serious long-term conditions. Controversies in Obesity takes the unique approach of assessing the controversies surrounding obesity, thus seeking to debunk the myths and highlight and explore the genuine science, whilst demonstrating areas where there is healthy debate. This book will appeal to primary care physicians, trainees and specialist nurses involved in care of the obese patient, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of obesity and its management.
- Topic I. Structure and function. Peptide substrates of dipeptidyl peptidases / Inger Brandt ... [et al.] Phosphorus-containing inhibitors of proteolytic enzymes / Angel Stöckel-Maschek ... [et al.] Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 / Xin Chen. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling / Melissa R. Pitman, R. Ian Menz, and Catherine A. Abbott -- Topic II. DPIV-related enzymes. Structure and function in dipeptidyl peptidase IV and related proteins / Mark D. Gorrell ... [et al.] Expression and function of dipeptidyl peptidase IV and related enzymes in cancer / Petr Busek ... [et al.] DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration, and apoptosis / Denise M.T. Yu ... [et al.] In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII / Marie-Berthe Maes ... [et al.] Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells / Sabine Wrenger ... [et al.] Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities / Joohong Park ... [et al.] Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits and unknown post-cysteine cleavage specificity / Joachim Wolfgang Bär ... [et al.] Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR / Leona Wagner ... [et al.] -- Topic III. Metabolic disorders. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM) / Simon A. Hinke, Raymond A. Pederson, and Christopher H.S. McIntosh. Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y / Lijun Li, Hans-Ulrich Demuth, and Zofia Zukowska -- Topic IV. Immune disorders. Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases: proof of concept in a mouse model of colitis / Ute Bank ... [et al.] Dipeptidyl peptidases and inflammatory bowel disease / Catherine A. Abbott ... [et al.] Possible role of DP IV inhibitors in acne therapy / Anja Thielitz ... [et al.] Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases? / Eva Balaziova ... [et al.] -- Topic V. Neuronal diseases. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation / Aliza Biton ... [et al.] CD26/DP IV in T cell activation and autoimmunity / Vera Preller ... [et al.] DPIV/CD26 and FAP in cancer: a tale of contradictions / Melanie L. Sulda, Catherine A. Abbott, and Martin Hildebrandt. Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells / Monica Salamone ... [et al.] Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin / Xin M. Wang ... [et al.] Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth / Joanna Kitlinska ... [et al.] The role of CD26/DPP IV in preservation of early pulmonary graft function / Florian Johannes Jung ... [et al.].
- "Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity"--Provided by publisher.
- Drug metabolism current concepts 2005Springer
- Dynamics of bone and cartilage metabolism. 2nd ed. 2006ScienceDirectStructure, biosynthesis and gene regulation of collagens in cartilage and bone / Klaus von der Mark -- Fibrillogenesis and maturation of collagens / Simon P. Robins -- Vitamin K dependent proteins of bone and cartilage / Caren M. Gundberg and Satoru K. Nishimoto -- Noncollagenous proteins: glycoproteins and related proteins / Dick Heinegård, Pilar Lorenzo, and Tore Saxne -- Proteoglycans and glycosaminoglycans / Tim Hardingham -- Growth factors / Philippa Hulley, Graham Russell, and Peter Croucher -- Prostaglandins and proinflammatory cytokines / Lawrence G. Raisz and Joseph A. Lorenzo -- Integrins and other adhesion molecules / M.H. Helfrich and M.A. Horton -- Alkaline phosphatases / José Luis Millán -- Acid phosphatases / Helena Kaija ... [et al.] -- Matrix proteinases / Ian M. Clark and Gillian Murphy -- Mineralization, structure and function of bone / Adele L. Boskey -- Bone structure and strength / Ego Seeman -- The cells of bone / Jane B. Lian and Gary S. Stein -- Signaling in bone / T. John Martin and Natalie A. Sims -- Parathyroid hormone: structure, function and dynamic actions / Lorraine A. Fitzpatrick and John P. Bilezikian -- Interaction of parathyroid hormone-related peptide with the skeleton / David Goltzman -- The vitamin D hormone and its nuclear receptor: mechanisms involved in bone biology / Geert Carmeliet ... [et al.] -- Sex steroid effects on bone metabolism / David G. Monroe, Thomas C. Spelsberg, and S. Khosla -- Physiology of calcium and phosphate homeostasis / René Rizzoli and Jean-Philippe Bonjour -- The central control of bone remodelling / Paul A. Baldock ... [et al.] -- New concepts in bone remodeling / David W. Dempster and Hua Zhou -- Products of bone collagen metabolism / Juha Risteli and Leila Risteli -- Supramolecular structure of cartilage matrix / Peter Bruckner -- Products of cartilage metabolism / Daniel-Henri Manicourt, Jean-Pierre Devogelaer, and Eugene J.-M.A. Thonar -- Fluid dynamics of the joint space and trafficking of matrix products / Peter A. Simkin -- Transgenic models of bone disease / Barbara E. Kream and John R. Harrison -- The role of genetic variation in osteoporosis / André G. Uitterlinden ... [et al.] -- Measurement of calcium, phosphate and magnesium / Heinrich Schmidt-Gayk -- Measurement of parathyroid hormone / Harald Jüppner and Ghada El-Hajj Fuleihan -- New horizons for assessment of vitamin D status in man / Gary L. Lensmeyer, Neil Binkley, and Marc K. Drezner -- Measurement of biochemical markers of bone formation / Kim E. Naylor and Richard Eastell -- Measurement of biochemical markers of bone resorption / Marius E. Kraenzlin and Markus J. Seibel -- Variability in the measurement of biochemical markers of bone turnover / Tuan V. Nguyen, Christian Meier, and Markus J. Seibel -- Validation of biochemical markers of bone turnover / Kim Brixen and Erik Fink Eriksen -- Genetic markers of joint disease / Michel Neidhart, Renate E. Gay, and Steffen Gay -- Laboratory assessment of postmenopausal osteoporosis / Patrick Garnero and Pierre D. Delmas -- Monitoring anabolic treatment / John P. Bilezikian and Mishaela R. Rubin -- Monitoring of antiresorptive therapy / Christian Meier, Tuan V. Ngyen, and Markus J. Seibel -- Age-related osteoporosis and skeletal markers of bone turnover / Clifford J. Rosen -- Steroid-induced osteoporosis / Ian R. Reid -- Transplantation osteoporosis: biochemical correlates of pathogenesis and treatment / Carolina A. Moreira Kulak and Elizabeth Shane -- Secondary osteoporosis / Jean E. Mulder, Carolina A. Moreira Kulak, and Elizabeth Shane -- Osteomalacia and rickets / Marc K. Drezner -- Assessment of bone and joint diseases: renal osteodystrophy / Esther A. González, Ziyad Al Aly, and Kevin J. Martin -- Primary hyperparathyroidism / Shonni J. Silverberg, and John P. Bilezikian -- Paget's disease of bone / Andreas Grauer, Ethel Siris, and Stuart Ralston -- Metastatic bone disease / Jean-Jacques Body -- Rare bone diseases / Michael P. Whyte -- Osteogenesis imperfecta / Francis H. Glorieux and Frank Rauch -- Rheumatoid arthritis and other inflammatory joint pathologies / Steven R. Goldring and Mary B. Goldring -- Osteoarthritis and degenerative spine pathologies / Kristina Åkesson.
- Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Programs Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.
- This volume updates its classic predecessor in both content and format. Written by two of the respected authorities in diagnostic endocrinology, it includes detailed information on how to perform and interpret those laboratory test procedures used to confirm the clinical diagnosis of the majority of known endocrine disorders. Newly designed, it provides a standardized format that makes it easier to access complete information about the diagnosis, screening, and management of traditional and newly perceived endocrine disorders. It provides sample calculations to assist with complex formulas as well as ICD-9 codes for all procedures.
- Energy balance and cancer v. 1-, 2011-Springer
- Energy balance and gastrointestinal cancer 2012SpringerThe gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
- Energy balance and hematologic malignancies 2012SpringerThe obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and fat metabolism. This volume on Energy Balance in Hematologic Malignancies will provide an important volume in this series and a basis for better understanding etiology, mechanisms, therapeutics implications and experimental approaches. This volume of energy balance and cancer will focus on the relation of obesity to hematologic malignancies, the epidemiology, potential mechanisms, and thereapeutic considerations including effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance.
- Molecular Physiology of Monogenic and Syndromic Obesities in Humans / Wendy K. Chung and Rudolph L. Leibel -- Leptin Signaling In the Brain / Ofer Reizes, Stephen C. Benoit, and Deborah J. Clegg -- Inactivating Melanocortin-4 Receptor Mutations and Human Obesity / Ya-Xiong Tao -- The Role of Central Melanocortins in Cachexia / Daniel L. Marks -- The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology / Robert H. Lustig -- Adiponectin: A Multifunctional Adipokine / Kristen Clarke and Robert L. Judd -- The Role of the Gastrointestinal Hormones Ghrelin, Peptide YY and Glucagon-like Peptide-1 in the Regulation of Energy Balance / Ruben Nogueiras, Hilary Wilson, Diego Perez-Tilve and Matthias H. Tschöp -- The Role of Growth Hormone Secretagogues and Ghrelin in Feeding and Body Composition / Cyril Y. Bowers, Blandine Laferrère, David Hurley, and Johannes D. Veldhuis -- Interaction Between Physical Activity and Genetic Factors in Complex Metabolic Disease / Paul W. Franks and Stephen M. Roth -- 11ss-Hydroxysteroid Dehydrogenase Type 1 and Obesity / Roland H. Stimson and Brian R. Walker -- Prader-Willi Syndrome : A Model of Disordered Energy Homeostasis / Andrea Haqq -- Antipsychotic Medication-Induced Weight Gain and Risk for Diabetes and Cardiovascular Disease / John W. Newcomer -- Treatment of Insulin Resistance in Youth: The Role of Metformin / Molly Emott and Michael Freemark -- The Surgical Approach to Morbid Obesity / Edward E. Mason, Mohammad K. Jamal and Thomas O'Dorisio.
- Exercise, energy balance, and cancer 2013SpringerAlthough it is well established that the worldwide pandemic of overweight and obesity has profound effects on promoting cancer, it is now recognized that alternative aspects of energy balance, namely physical activity and exercise have significant beneficial effects on all aspects of cancer across the spectrum from prevention through treatment and extending through survivorship. While the effect of physical activity and exercise on cancer may be partially mediated through obesity control, it is clear that considerable research is required and is ongoing at both the molecular and clinical levels to better understand the associated mechanisms and to develop optimal exercise strategies. This volume presents the effects of exercise on biological pathways in tumor growth, state of the art exercise strategies and cutting edge research focused on different cancers and patient groups. This important text will provide a basis for ongoing research, experimental approaches and application of evidence based practices to clinical care for patients with cancer.
- Fabry disease perspectives from 5 years of FOS 2006NCBI Bookshelf
- The fattest generation -- Obese twins and thrifty genes -- Size, health, and self-esteem -- Teaching children how to eat for life -- Off the couch and away from the screen -- Programming babies for health, before and after birth -- Eating lessons at school -- Finding help for an overweight child -- Action for healthy communities.
- Principles of acid-base physiology -- Tools to use to diagnose acid-base disorders -- Metabolic acidosis: clinical approach -- Metabolic acidosis due to a deficit of NaHCO₃ -- Ketoacidosis -- Metabolic acidosis: acid gain types -- Metabolic alkalosis -- Respiratory acid-base disturbances -- Sodium and waterphysiology -- Hyponatremia -- Hypernatremia -- Polyuria -- Potassium physiology -- Hypokalemia -- Hyperkalemia -- Hyperglycemia.
- Food, diet and obesity 2005CRCnetBASE
- Frontiers in gynecological endocrinology. Volume 2, From basic science to clinical application 2015SpringerThis volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women?s health as well as interested GPs.
- Gaucher disease 2006CRCnetBASEChapter 1. Introduction: Overview and Historical Perspective / Roscoe O. Brady -- Chapter 2. Gaucher Disease: Molecular Biology and Genotype-Phenotype Correlations / Kathleen S. Hruska, Mary E. LaMarca, and Ellen Sidransky -- Chapter 3. Cell Biology and Biochemistry of Acid β-Glucosidase: The Gaucher Disease Enzyme / Gregory A. Grabowski, Andrzej Kazimierczuk, and Benjamin Liou -- Chapter 4. Saposin C and Other Sphingolipid Activator Proteins / Silvia Locatelli Hoops, Thomas Kolter, and Konrad Sandhoff -- Chapter 5. The X-Ray Structure of Human Acid-β-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy / Lakshmanane Premkumar, Israel Silman, Joel L. Sussman, and Anthony H. Futerman -- Chapter 6. Cellular Pathology in Gaucher Disease / Anthony H. Futerman -- Chapter 7. The Biochemistry and Cellular Biology of Sphingolipids and Glucosylceramide / James A. Shayman -- Chapter 8. The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond / Edward H. Schuchman and Silvia Muro -- Chapter 9. Gaucher Disease Animal Models / Ying Sun, You-Hai Xu, and Gregory A. Grabowski -- Chapter 10. Type 1 Gaucher Disease - Clinical Features / Pramod K. Mistry and Ari Zimran -- Chapter 11. Neuronopathic Gaucher Disease / Raphael Sc hiffmann and Ashok Vellodi -- Chapter 12. Pathologic Anatomy of Gaucher Disease: A Pictorial Essay / Robert E. Lee -- Chapter 13. Neuropathological Aspects of Gaucher Disease / Kondi Wong -- Chapter 14. Diagnosis and Laboratory Features / Carla E.M. Hollak and Johannes M.F.G. Aerts -- Chapter 15. Imaging in Gaucher Disease, Focusing on Bone Pathology / Mario Maas and Erik M. Akkerman -- Chapter 16. Radionuclide Evaluation of Gaucher Disease / Giuliano Mariani and Paola A. Erba -- Chapter 17. Epidemiology and Screening Policy / Peter J. Meikle, Maria Fuller, and John J. Hopwood Chapter 18. Enzyme Replacement Therapy for Type I Gaucher Disease / Ari Zimran, Bruno Bembi, and Gregory M. Pastores -- Chapter 19. Substrate Reduction Therapy / Frances M. Platt and Timothy M. Cox -- Chapter 20. Pharmacologic Chaperone Therapy for Lysosomal Diseases / Robert J. Desnick and Jian-Qiang Fan -- Chapter 21. The Significance of the Blood-Brain Barrier for Gaucher Disease and Other Lysosomal Storage Diseases / David J. Begley -- Chapter 22. Hematopoietic Stem Cell Transplantation, Stem Cells, and Gene Therapy / Charles Peters and William Krivit -- Chapter 23. Ethical Concerns in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avraham Steinberg -- Chapter 24. Societal Aspects in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avi Israeli -- Chapter 25. Gaucher Disease as a Model for an Orphan Disease: Medical Aspects / Jill Waalen and Ernest Beutler -- Chapter 26. Meeting the Needs of Patients with Gaucher Disease: Pioneering a Sustainable Model for Ultra-Orphan Diseases / David P. Meeker and Henri A. Termeer -- Chapter 27. Patients’ Perspective / Susan Lewis, Tanya Collin-Histed, Jeremy Manuel, and Greg Macres -- Chapter 28. Societal Perspective: Comment / Abby Alpert, Alan M. Garber, and Dana P. Goldman -- Chapter 29. Gaucher Associations Around the World.
- Genetics of obesity 2014SpringerIn the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
- Ghrelin in health and disease 2012SpringerGhrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
- Global perspectives on childhood obesity current status, consequences and prevention. 1st ed. 2011ScienceDirectChapter 1. Pediatric Obesity: A Pediatrician's Viewpoint / Allison Collins, Rebecka Peebles -- Chapter 2. Salient Features on Child Obesity from the Viewpoint of a Nutritionist / Bernard Waysfeld, Dominique Adele Cassuto -- Chapter 3. Developmental Trajectories of Weight Status in Childhood and Adolescence / Samar Hejazi, V. Susan Dahinten, Pamela A. Ratner, Sheila K. Marshall -- Chapter 4. The Measurement and Epidemiology of Child Obesity / David S. Freedman, Cynthia L. Ogden, Sarah E. Cusick -- Chapter 5. Good-Enough Parenting, Self-Regulation, and the Management of Weight-Related Problems / Moria Golan -- Chapter 6. Nursing Perspective on Childhood Obesity / Cynthia Yensel, Carrie Tolman -- Chapter 7. Contemporary Racial/Ethnic and Socioeconomic Patterns in U.S. Childhood Obesity / Gopal K. Singh, Michael D. Kogan -- Chapter 8. Prediabetes among Obese Youth / Orit Pinhas-Hamiel, Phil Zeitler -- Chapter 9. Prediabetes and Type 2 Diabetes: An Emerging Epidemic among Obese Youth / Kathryn Love-Osborne -- Chapter 10. Prevalence of the Metabolic Syndrome in U.S. Youth / Sarah E. Messiah, Kristopher L. Arheart, Steven E. Lipshultz, Tracie L. Miller -- Chapter 11. Emerging Pathways to Child Obesity Starts from the Mother's Womb: A Prospective View / Ashik Mosaddik -- Chapter 12. The Social, Cultural and Familial Contexts Contributing to Childhood Obesity / Cathy Banwell, Helen Kinmonth, Jane Dixon -- Chapter 13. Cardiovascular Risk Clustering in Obese Children / Ram Weiss -- Chapter 14. A Link between Maternal and Childhood Obesity / Siân Robinson -- Chapter 15. Is Prenatal Exposure to Maternal Obesity Linked to Child Mental Health? / Alina Rodriguez -- Chapter 16. Sleep and Obesity in Children and Adolescents / Amy Darukhanavala, Silvana Pannain -- Chapter 17. Cellular Remodeling during the Growth of the Adipose Tissue / Coralie Sengenès, Virginie Bourlier, Jean Galitzky, Alexia Zakaroff-Girard, Max Lafontan, Anne Bouloumié -- Chapter 18. Children Obesity, Glucose Tolerance, Ghrelin, and Prader-Willi Syndrome / Simonetta Bellone, Arianna Busti, Sara Belcastro, Gianluca Aimaretti, Gianni Bona, Flavia Prodam -- Chapter 19. Insulin Resistance and Glucose Metabolism in Childhood Obesity / Subhashini Yaturu, Sushil K. Jain -- Chapter 20. Insulin Resistance in Pediatric Obesity: Physiological Effects and Possible Diet Treatment / Ulf Holmbäck -- Chapter 21. Role of Fatty Liver Disease in Childhood Obesity / Valerio Nobili, Anna Alisi, Melania Manco -- Chapter 22. An Overview of Psychosocial Symptoms in Obese Children / Lisa Y. Gibson -- Chapter 23. Childhood Obesity: Depression, Anxiety and Recommended Therapeutic Strategies / Dana L. Rofey, Jessica J. Black, Jennifer E. Phillips, Ronette Blake, KayLoni Olson -- Chapter 24. The Emotional Impact of Obesity on Children / Robert E. Cornette -- Chapter 25. Psychiatric Illness, Psychotropic Medication, and Childhood Obesity / Lawrence Maayan, Leslie Citrome -- Chapter 26. Childhood Obesity: Public Health Impact and Policy Responses / Rogan Kersh, Brian Elbel -- Chapter 27. Childhood Obesity and Juvenile Diabetes / Mikael Knip -- Chapter 28. Bone Health in Obesity and the Cross Talk between Fat and Bone / Sowmya Krishnan, Venkataraman Kalyanaraman -- Chapter 29. A Community-Level Perspective for Childhood Obesity Prevention / Christina Economos, Erin Hennessy -- Chapter 30. School-Based Obesity-Prevention Programs / Genevieve Fridlund Dunton, Casey P. Durand, Nathaniel R. Riggs, Mary Ann Pentz -- Chapter 31. School-Based Obesity Prevention Interventions Show Promising Improvements in the Health and Academic Achievements among Ethnically Diverse Young Children / Danielle Hollar, Sarah E. Messiah, Gabriela Lopez-Mitnik, T. Lucas Hollar, Michelle Lombardo -- Chapter 32. School and Community-Based Physical Education and Healthy Active Living Programs: Holistic Practices in Hong Kong, Singapore, and the United States / Ming-Kai Chin, Christopher R. Edginton, Mei-Sin Tang, Kia-Wang Phua, Jing-Zhen Yang -- Chapter 33. Schools as “Laboratories” for Obesity Prevention: Proven Effective Models / Michelle Lombardo, Danielle Hollar, T. Lucas Hollar, Karen McNamara -- Chapter 34. Fitness and Fatness in Childhood Obesity: Implications for Physical Activity / Sarah P. Shultz, Benedicte Deforche, Nuala M. Byrne, Andrew P. Hills -- Chapter 35. Pharmacotherapy in Childhood Obesity / Amélio F. Godoy-Matos, Erika Paniago Guedes, Luciana Lopes de Souza, Mariana Farage -- Chapter 36. Beverage Interventions to Prevent Child Obesity / Rebecca Muckelbauer, Mathilde Kersting, Jacqueline Müller-Nordhorn -- Chapter 37. Psychotherapy as an Intervention for Child Obesity / Carl-Erik Flodmark -- Chapter 38. Childhood Obesity: Psychological Correlates and Recommended Therapeutic Strategies / Jennifer E. Phillips, Ethan E. Hull, Dana L. Rofey -- Chapter 39. Dietary Supplements in the Prevention and Treatment of Childhood Obesity / Robert I-San Lin -- Chapter 40. The Role of Arginine for Treating Obese Youth / Catherine J. McNeal, Guoyao Wu, Susie Vasquez, Don P. Wilson, M. Carey Satterfield, Jason R. McKnight, Hussain S. Malbari, Mujtaba Rahman -- Chapter 41. Prevention of Childhood Obesity with Use of Natural Products / Jin-Taek Hwang, Dae Young Kwon, Joohun Ha -- Chapter 42. The Role of United States Law to Prevent and Control Childhood Obesity / Jennifer L. Pomeranz -- Chapter 43. Childhood Obesity as an Amplifier of Societal Inequality in the United States / Stanley J. Ulijaszek -- Chapter 44. Childhood Obesity, Food Choice and Market Influence / Jane Kolodinsky, Amanda Goldstein, Erin Roche -- Chapter 45. The Role of Media in Childhood Obesity / Amy B. Jordan, Ariel Chernin -- Chapter 46. Evaluation and Management of Childhood Obesity in Primary Care Settings / Goutham Rao -- Chapter 47. The Future Directions and Clinical Management of Childhood Obesity / Clodagh S. O'Gorman, Jonathan Cauchi, Jill K. Hamilton, Denis Daneman.
- The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with growing demand. This book aims to provide guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Epidemiology, organizational and logistical aspects, nursing issues, patient assessment, anesthesiology, and surgical practicalities are expertly covered in the opening chapters. Techniques of relevance to the general surgeon are described according to anatomic region, covering the head and neck; cardiothoracic and vascular system; upper and lower GI tract; pancreas, liver and adrenal glands; urinary tract and kidneys; the reproductive system; and the abdominal wall. Results achieved by bariatric surgery worldwide are reviewed, and the book closes with a chapter devoted to plastic and reconstructive surgery. The Globesity Challenge to General Surgery highlights a need for global rethinking on public health as regards resource allocation and patterns and standards of care, improving outcomes through greater affordability.
- Origins of obesity in the scientific era : 1500 AD to the present -- Definitions, measurement, and prevalence -- Genetic, metabolic, and social origins of obesity -- Effects of obesity on health and metabolism -- Prevention, evaluation, and introduction to treatment -- Lifestyle, diet, & exercise : cognitive solutions -- Medications for obesity -- Surgery for obesity -- Post-script : obesity in the twenty first century.
- Handbook of childhood and adolescent obesity 2008SpringerPediatric obesity: trends and epidemiology / Ric G. Steele, Timothy D. Nelson, and Elissa Jelaian -- Health consequences of obesity in children and adolescents / Patrick Vivier and Christine Tompkins -- Psychological factors related to obesity in children and adolescents / Meg H. Zeller and Avani C. Modi -- Binge eating among children and adolescents / Marian Tanofsky-Kraff -- The definition and assessment of childhood overweight: a development perspective / Chermaine Tyler and Ginny Fullerton -- Diet assessment in children and adolescents / Nancy E. Sherwood -- Development of eating patterns / Vicky Phares, Jessica Curley, and Ariz Rojas -- Physiological mechanisms impacting weight regulation / David Fields and Paul Higgins -- Socioeconomic factors related to obesity in children and adolescents / Elizabeth Goodman -- The obesogenic environment / Amy A. Gorin and Melissa M. Crane -- Application of genetic epidemiology to understanding pediatric obesity / Robert Mair and Stephen T. McGarvey -- Development considerations in the prevention of pediatric obesity / Melissa Xanthopoulos, Chantelle Hart, and Elissa Jelalian -- Evidence-based treatments for childhood obesity / Hollie A. Raynor -- Empirically supported treatment of overweight adolescents / Alan M. Delamater ... [et al.] -- Intensive therapies for the treatment of pediatric obesity / Joan C. Han and Jack A. Yanovski -- Residential treatment programs for pediatric obesity / Paul J. Gately and Carlton B. Cooke -- Model treatment programs / Ann McGrath Davis and Rochelle L. James -- Cultural considerations in the development of pediatric weight management interventions / Dawn K. Wilson and Heather Kitzman-Ulrich -- Prevention of childhood obesity in childcare settings / Barbara A. Dennison and Myles S. Faith -- Obesity prevention programs for school-aged children and adolescents / David M. Janicke, Bethany J. Sallinen, and Jessica C. White Plume -- Preventing childhood obesity through collaborative public health action in communities / Vicki L. Collie-Akers and Stephen B. Fawcett -- The role of public policy in addressing the pediatric obesity epidemic / Patricia B. Crawford ... [et al.] -- Application of innovative technologies in the prevention and treatment of overweight in children and adolescents / Deborah F. Tate -- Motivational interviewing and pediatric obesity / Robyn S. Mehlenbeck and Yana Markov Wember -- Treatment of children and adolescents with obesity and comorbid psychiatric conditions / Alan Zametkin, Alanna Jacobs, Jessica Parrish -- Application of empirically supported treatments to clinical settings / Craig A. Johnston and William T. Dalton III -- Future directions in pediatric obesity prevention and intervention: research and practice / Elissa Jelalian, Ric G. Steele, and Chad D. Jensen.
- Why obesity prevention? -- What is obesity? Definitions matter -- Descriptive epidemiology of obesity in the United States -- Costs of obesity -- Obesity prevention concepts and frameworks -- Consumer perspectives and consumer action -- The role of government in preventing obesity -- Planning and the built environment -- The food industry role in obesity prevention -- Media, marketing and advertising and obesity -- Global context of obesity -- Organizational change for obesity prevention-perspectives, possibilities and potential pitfalls -- Community-based approaches to obesity prevention: the role of environmental and policy change -- Health care system approaches to obesity -- Workplace approaches to obesity prevention -- Obesity prevention in school and group child care settings -- Individual behavior change -- Obesity risk factors and prevention in early life: pre-gestation through infancy -- Obesity prevention during preschool and elementary school-age years -- Obesity prevention during preadolescence and adolescence -- Obesity prevention during adulthood -- Obesity prevention: charting a course to a healthier future.
- Homocysteine in protein structure/function and human disease chemical biology of homocysteine-containing proteins 2013SpringerExcess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
- How gut and brain control metabolism 2014KargerHormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis / Kalsbeek, A.; Bruinstroop, E.; Yi, C.-X.; Klieverik, L.; Liu, J.; Fliers, E. -- The blood-brain barrier as a regulator of the gut-brain axis / Schaeffer, M.; Hodson, D.J.; Mollard, P. -- The brain modulates insulin sensitivity in multiple tissues / Parlevliet, E.T.; Coomans, C.P.; Rensen, P.C.N.; Romijn, J.A. -- The important role of sleep in metabolism / Copinschi, G.; Leproult, R. ; Spiegel, K. -- Metabolic interplay between gut bacteria and their host / Duca, F.; Giard, P.; Covasa, M.; Lepage, P. -- The brain-stomach connection / Folgueira, C.; Seoane, L.M.; Casanueva, F.F. -- Prader-Willi syndrome as a model of human hyperphagia / Tauber, M.; Diene, G.; Mimoun, E.; Aabal-Berthoumieu, S.; Mantoulan, C.; Molinas, C.; Muscatelli, F.; Salles, J.P. -- Interactions between the gut, the brain and brown adipose tissue function / van den Beukel, J.C.; Grefhorst, A. -- Gut sweet taste receptors and their role in metabolism / Meyer-Gerspach, A.C.; Wilnerhanssen, B.; Beglinger, C. -- What is the role of metabolic hormones in taste buds of the tongue / Cai, H.; Maudsley, S.; Martin, B. -- Protein PYY and its role in metabolism / Price, S.L.; Bloom, S.R. -- Nutropioids regulate the gut-brain circuit controlling food intake / Mithieux, G. -- Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? / Delhanty, P.J.D.; Neggers, S.J.; van der Lely, A.J. -- Obestatin : is it really doing something? / Trovato, L.; Gallo, D.; Settanni, F.; Gesmundo, I.; Ghigo, E.; Granata, R.
- Hypothalamic integration of energy metabolism proceedings of the 24th International Summer School of Arts and Sciences, Amsterdam, The Netherlands, 29 August - 1 September 2005. 1st ed. 2006ScienceDirect
- This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. ?These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.
- I. Diagnosis and Treatment: General Principles -- 1. Clinical Approach to Inborn Errors of Metabolism in Pediatrics / Jean-Marie Saudubray -- 2. Inborn Errors of Metabolism in Adults: A Diagnostic Approach to Neurological and Psychiatric Presentations / Frédéric Sedel -- 3. Newborn Screening for Inborn Errors of Metabolism / Bridget Wilcken, Piero Rinaldo, Dietrich Matern -- 4. Diagnostic Procedures: Functional Tests and Post-mortem Protocol / Guy Touati, Fanny Mochel, Daniel Rabier -- 5. Emergency Treatments / Carlo Dionisi-Vici, Hélène Ogier de Baulny -- II. Disorders of Carbohydrate Metabolism -- 6. The Glycogen Storage Diseases and Related Disorders / Pascal Laforêt, David A. Weinstein, G. Peter, A. Smit -- 7. Disorders of Galactose Metabolism / Gerard T. Berry, John H. Walter -- 8. Disorders of the Pentose Phosphate Pathway / Mirjam M.C. Wamelink, Vassili Valayannopoulos, Cornelis Jakobs -- 9. Disorders of Fructose Metabolism / Beat Steinmann, René Santer -- 10. Persistent Hyperinsulinaemic Hypoglycaemia / Pascale de Lonlay, Jean-Marie Saudubray -- 11. Disorders of Glucose Transport / René Santer, Jörg Klepper -- III. Disorders of Mitochondrial Energy Metabolism -- 12. Disorders of Pyruvate Metabolism and the Tricarboxylic Acid Cycle / Linda J. De Meirleir, Michèle Brivet, Angeles Garcia-Cazorla -- 13. Disorders of Mitochondrial Fatty Acid Oxidation and Related Metabolic Pathways / Andrew A.M. Morris, Ute Spiekerkoetter -- 14. Disorders of Ketogenesis and Ketolysis / Andrew A.M. Morris -- 15. Defects of the Respiratory Chain / Arnold Munnich, Agnès Rötig, Marlène Rio -- 16. Creatine Deficiency Syndromes / Sylvia Stöckler-Ipsiroglu, Saadet Mercimek- Mahmutoglu, Gajja S. Salomons -- IV. Disorders of Amino Acid Metabolism and Transport -- 17. Hyperphenylalaninaemia / John H. Walter, Robin H. Lachmann, Peter Burgard -- 18. 18 Disorders of Tyrosine Metabolism / Anupam Chakrapani, Paul Gissen, Patrick McKiernan -- 19. Branched-chain Organic Acidurias/Acidaemias / Hélène Ogier de Baulny, Carlo Dionisi-Vici, Udo Wendel -- 20. Disorders of the Urea Cycle and Related Enzymes / Frits A. Wijburg, Marie-Cécile Nassogne -- 21. Disorders of Sulfur Amino Acid Metabolism / Generoso Andria, Brian Fowler, Gianfranco Sebastio -- 22. Disorders of Ornithine Metabolism / Matthias R. Baumgartner, David Valle -- 23. Cerebral Organic Acid Disorders and Other Disorders of Lysine Catabolism / Georg F. Hoffmann, Stefan Kölker -- 24. Nonketotic Hyperglycinaemia (Glycine Encephalopathy) / Olivier Dulac, Marie-Odile Rolland --25. Disorders of Proline and Serine Metabolism / Jaak Jaeken -- 26. Transport Defects of Amino Acids at the Cell Membrane: Cystinuria, Lysinuric Protein Intolerance and Hartnup Disorder / Kirsti Näntö-Salonen, Harri Niinikoski, Olli G. Simell -- V. Vitamin-Responsive Disorders -- 27. Biotin-responsive Disorders / Matthias R. Baumgartner, Terttu Suormala -- 28. Disorders of Cobalamin and Folate Transport and Metabolism / David Watkins, David S. Rosenblatt, Brian Fowler -- VI. Neurotransmitter and Small Peptide Disorders -- 29. Disorders of Neurotransmission / Àngels García-Cazorla, K. Michael Gibson, Peter T. Clayton -- 30. Disorders in the Metabolism of Glutathione and Imidazole Dipeptides / Ertan Mayatepek, Jaak Jaeken -- 31. Trimethylaminuria and Dimethylglycine Dehydrogenase Deficiency / Valerie Walker, Ron A. Wevers -- VII. Disorders of Lipid and Bile Acid Metabolism -- 32. Dyslipidaemias / Annabelle Rodriguez-Oquendo, Peter O. Kwiterovich, Jr. -- 33. Disorders of Cholesterol Synthesis / Hans R. Waterham, Peter T. Clayton -- 34. Disorders of Bile Acid Synthesis / Peter T. Clayton -- 35. Disorders of Phospholipid and Glycosphingolipid Synthesis / Foudil Lamari, Fréderic Sédel, Jean-Marie Saudubray -- VIII. Disorders of Nucleic Acid and Heme Metabolism -- 36. Disorders of Purine and Pyrimidine Metabolism / Georges van den Berghe, M.-Françoise Vincent, Sandrine Marie -- 37. Disorders of Haem Biosynthesis / Charles Marquez Lourenço, Chul Lee, Karl E. Anderson -- IX. Disorders of Metal Transport -- 38. Disorders in the Transport of Copper, Iron, Magnesium, Manganese, Selenium and Zinc / Marc Bierings, Peter Clayton, Roderick H.J. Houwen -- X. Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- 39. Disorders of Sphingolipid Metabolism and Neuronal Ceroid-Lipofuscinoses / Marie T. Vanier, Catherine Caillaud -- 40. Mucopolysaccharidoses and Oligosaccharidoses / J. Ed Wraith -- 41. Peroxisomal Disorders / Bwee Tien Poll-The, Patrick Aubourg, Ronald J.A. Wanders -- 42. Congenital Disorders of Glycosylation / Jaak Jaeken -- 43. Cystinosis / Michel Broyer, Patrick Niaudet -- Appendix A. Medications Used in the Treatment of Inborn Errors / JH Walter and JE Wraith.
- Inherited metabolic diseases a clinical approach 2010Springer
- Leptin-- regulation and clinical applications 2015SpringerTwenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
- Lipid management from basics to clinic 2015SpringerThis timely, concise title provides an important update on clinical lipid management. Using information from recent clinical trials and in special populations, the book begins by offering an easy-to-read overview of LDL, HDL, and triglyceride metabolism and the genetics of lipid disorders. The link between inflammation and lipids, and how this relates to atherosclerosis development, is also addressed, as are the measures of subclinical atherosclerosis in patients with abnormal lipid levels. Lipid abnormalities in children, with a particular focus on vulnerable populations (with an emphasis on ethnicity and childhood obesity), are covered. The treatment goals and approaches for managing lipids in the clinic are thoroughly discussed, emphasizing the important role of statin use and addressing controversies of lipid management in special populations such as heart failure, end stage kidney disease and fatty liver disease. Of special note, an important update on how new HIV medications impact lipid levels is provided. In all, Lipid Management: From Basics to Clinic, is an invaluable, handy resource for understanding changes in lipids in different populations and for sharpening the clinical approach to managing complicated lipid cases.
- Lipid metabolism and health 2006CRCnetBASE
- Lysosomal storage disorders 2007Springer
- Management of eating disorders and obesity. 2nd ed. 2005SpringerBulimia nervosa / Steven J. Romano -- Counseling patients with bulimia nervosa / Tricia Cook Myers and James E. Mitchell -- Pharmacologic therapy of bulimia nervosa / James I. Hudson, Harrison G. Pope, Jr., and William P. Carter -- Prevention of eating disorders: a nutritional perspective / Cheryl L. Rock -- Anorexia nervosa / Steven J. Romano -- Treatment of anorexia nervosa / L.K. George Hsu -- Pharmacological therapy for anorexia nervosa / Walter H. Kaye -- The Internet and eating disorders / David J. Goldstein -- Etiologies of obesity / Richard L. Atkinson -- Medical consequences of obesity and benefits of weight loss / Lalita Khaodhiar and George L. Blackburn -- Obese patients with binge-eating disorder / Marsha D. Marcus and Michele D. Levine -- Overview and the future of obesity treatment / Lisa Terre, Walker S.C. Poston II, and John P. Foreyt -- The role of physical activity, exercise, and nutrition in the treatment of obesity / Edward T. Mannix ... [et al.]. Lifestyle modification in the treatment of obesity / Anthony N. Fabricatore and Thomas A. Wadden -- Very low-calorie diets / Stephen D. Phinney -- Pharmacotherapy of obesity / George A. Bray -- Combination therapies for obesity / Richard L. Atkinson and Gabriel Uwaifo -- Genetics and potential treatments for obesity / José R. Fernández and David J. Goldstein -- The role of hunger and satiety in weight management / Michael Penn and David J. Goldstein -- Surgical interventions for the management of obesity / Scott A. Shikora, David Smith, and Julie J. Kim -- Clinical experience in a comprehensive weight-management center / Judy Loper and Richard A. Lutes -- The multidisciplinary team in the management of obesity / Patrick Mahlen O'Neil and Sherry Rieder -- The Internet and obesity treatment / David J. Goldstein -- Barriers to treatment / Arthur Frank -- Prevention of obesity / Barbara C. Hansen.
- Maternal obesity and pregnancy 2012SpringerEpidemiology of Diabetes and Obesity in Pregnancy / Robert Lindsay -- Fertility and Obesity / Ulrik Schiøler Kesmodel -- Clinical Consequences of Abnormal Glucose Metabolism / Dorte M. Jensen, Per Glud Ovesen and Patrick Catalano -- Clinical Management / Jenny Myers and Michael Maresh -- Physical Activity and Pregnancy / Bente Klarlund Pedersen -- Miscarriage and Malformations / Montserrat Balsells, Apolonia García-Patterson and Rosa Corcoy -- Maternal Obesity and Pregnancy / Michael Conall Dennedy and Fidelma Dunne -- Gestational Weight Gain / Christina Anne Vinter -- Maternal Diabesity and Developmental Programming in the Offspring / Thomas Harder, Joachim W. Dudenhausen and Andreas Plagemann -- Obesity in Pregnancy and Ultrasound / Ute M. Schaefer-Graf -- Maternal Obesity and Macrosomia / Kinneret Tenenbaum-Gavish and Moshe Hod -- Shoulder Dystocia in Maternal Obesity / Polly Weston, Jo Crofts and Tim Draycott -- Stillbirth and Infant Mortality / Ellen Aagaard Nohr -- Anaesthesia in Maternal Obesity / Ulla Bang and H. Soren Helbo-Hansen -- Macrosomia and Neonatology / Bartolomé Bonet -- Childhood Obesity: The Impact of Maternal Obesity on Childhood Obesity / Rebecca M. Reynolds -- Obesity in Pregnancy: Data from the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study / Harold David McIntyre, Lynn P. Lowe, Alan R. Dyer and Boyd E. Metzger -- Breastfeeding and Obesity: Impact on Women and Their Children / Tessa Crume and Dana Dabelea -- Pregnancy Following Bariatric Surgery / Isabelle Guelinckx, Roland Devlieger and Greet Vansant.
- Metabolic basis of obesity 2011SpringerPrinciples of human energy metabolism -- Intermediary metabolsim of carbohydrate, protein, and fat -- Adipose tissue development, structure and function -- Adipokines in health and disease -- Neural control of feeding and energy homeostasis -- Gastrointestinal hormones and obesity -- Genes and human obesity -- Classical hormones linked to obesity -- Inflammation and adipose dysfunction -- Insulin resistance in the metabolic syndrome -- Pancreatic islet €-cell failure in obesity -- Non-alcoholic fatty liver disease -- Sleep, circadian rhytms and metabolism -- Obesity and cardiac dysfunction -- Atherogenic lipid metabolism in obesity -- Gut microbes, immunity, and metabolism -- Impact of obesity on female reproductive health -- Lessons from HIV lipodystrophy -- Principles of obesity therapy.
- Metabolic maps pesticides, environmentally relevant molecules, and biologically active molecules 2001ScienceDirectAcid amides -- Amidines, guanidines, and hydrazines -- Amino acids: phosphinic acids -- Anilines and nitrobenzenes -- Aryloxy acids -- Biphenyl ethers -- Carbamates -- Dithio- and thiolcarbamates -- Halogenated aliphatics -- Halogenated aromatics -- Five-membered heterocycles -- Five-membered heterocycles (fused) -- Six-/more membered heterocycles -- Six-/more membered heterocycles (fused) -- Imides -- Natural products -- Organophosphorous compounds -- Oximes -- Phenylureas and related compounds -- Phosphono amino acids and related compounds -- Pyrethroids -- Sulfonylureas -- Triazines and related compounds -- Miscellaneous.
- Metabolic profiling methods and protocols 2011Springer ProtocolsOrigins of metabolic profiling / Arthur B. Robinson and Noah E. Robinson -- Amino acid profiling for the diagnosis of inborn errors of metabolism / Monique Piraud ... [et al.] -- Acylcarnitines : analysis in plasma and whole blood using tandem mass spectrometry / David S. Millington and Robert D. Stevens -- Analysis of organic acids and acylglycines for the diagnosis of related inborn errors or metabolism by GC- and HPLC-MS / Giancarlo la Marca and Cristiano Rizzo -- HPLC analysis for the clinical-biochemical diagnosis of inborn errors of metabolism of purines and pyrimidines / Giuseppe Lazzarino ... [et al.] -- Bile acid analysis in various biological samples using ultra performance liquid chromatography/electrospray ionization-mass spectrometry (UPLC/ESI-MS) / Masahito Hagio, Megumi Matsumoto, and Satoshi Ishizuka -- Analysis of glycolytic intermediates with ion chromatography- and gas chromatography-mass spectrometry / Jan C. van Dam, Cor Ras, and Angela ten Pierick -- Analysis of the citric acid cycle intermediates using gas chromatography-mass spectrometry / Rajan S. Kombu, Henri Brunengraber, and Michelle A. Puchowicz -- Quantification of pentose phosphate pathway (PPP) metabolites by liquid chromatography-mass spectrometry (LC-MS) / Amber Jannasch, Miroslav Sedlak, and Jiri Adamec -- High-performance liquid chromatography-mass spectrometry (HPLC-MS)-based drug metabolite profiling / Ian D. Wilson -- Gas chromatography-mass spectrometry (GC-MS)-based metabolomics / Antonia Garcia and Coral Barbas -- Use of two-dimensional gas chromatography-time-of-flight mass spectrometry (GCxGC-TOF-MS) for metabolomic analysis of polar metabolites / Kimberly Ralston-Hooper ... [et al.] -- LC-MS-based metabolomics / Sunil Bajad and Vladimir Shulaev -- Capillary electrophoresis-electrospray ionization-mass spectrometry (CE-ESI-MS)-based metabolomics / Philip Britz-McKibbin -- Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics for studies of body fluids and tissues / Heli Nygren ... [et al.] -- Electrospray ionization tandem mass spectrometry (ESI-MS/MS)- based shotgun lipidomics / Giorgis Isaac -- Processing and analysis of GC/LC-MS based metabolomics data / Elizabeth Want and Perrine Masson -- Nuclear magnetic resonance (NMR)-based drug metabolite profiling / Eva M. Lenz -- Nuclear magnetic resonance (NMR)-based metabolomics / Hector C. Keun and Toby J. Athersuch -- Slow magic angle sample spinning : a non- or minimally invasive method for high-resolution ¹H nuclear magnetic resonance (NMR) metabolic profiling / Jian Zhi Hu -- Processing and modeling of nuclear magnetic resonance (NMR) metabolic profiles / Timothy M. D. Ebbels, John C. Lindon, and Muireann Coen.
- "Metabolic Syndrome and Neurological Disorders brings together information on the cluster of common pathologies which cause metabolic syndrome - abdominal obesity linked to an excess of visceral fat, insulin resistance, dyslipidemia and hypertension - to provide a comprehensive and cutting edge exploration of the link between metabolic syndrome and neurological disorders. Metabolic syndrome is recognized to play a role in neurological disorders such as stroke, Alzheimer's disease, and depression. For the first time in book form, Metabolic Syndrome and Neurological Disorders covers the molecular mechanisms thought to underlie this mirror relationship, as well as how lifestyle and other factors such as oxidative stress and inflammation may play a role in the disease. Grounded in a series of epidemiological studies of metabolic-cognitive syndrome, this book will be a valuable reference for researchers, dietitians, nutritionists, and physicians"--Provided by publisher.
- Metabolic syndrome and obesity 2007SpringerDefinitions and prevalence -- How do we get fat?: an epidemiological and metabolic approach -- Costs, pathology, and health risks of obesity and the metabolic syndrome -- Natural history of obesity: differential diagnosis, clinical types, and age-related changes -- Evaluation, prevention, and introduction to treatment -- Diet -- Behavior modification -- Physical activity and exercise in the obese -- Pharmacological treatment of the overweight patient -- Should we treat the metabolic syndrome or its components? -- Surgical treatment for the overweight patient.
- Definitions and clinical aspects. Definitions -- Hypothalamic obesity in children -- Causes. Genetics of obesity in childhood and adolescence -- Nutrition -- Sedentary lifestyle -- Socio-economic aspects -- Consequences. Carbohydrate metabolism -- Orthopaedic aspects of obesity in children and adults -- Urogenital complications: renal disease, urolithiasis and lower urinary tract symptoms -- Influences of childhood obesity on pubertal development -- Social aspects and prevention. Urban living conditions: the relation between neighborhood characteristics and obesity in children and adolescents -- Metabolic syndrome and the 'Western diet': science and politics -- An economic perspective on childhood obesity -- Prevention of childhood and adolescent obesity and its barriers -- E-health in overweight and obesity prevention -- Obesity management. Obesity treatment programmes -- Adolescent bariatric surgery: current status in an evolving field -- Beyond weight loss: experiences and insights related to working effectively with families and operating within the health care system to manage pediatric obesity.
- Part 1. Metabolic Syndrome - Past and Future -- Metabolic Syndrome - Past and Future : An Introduction to the Features of This Book / Barbara Caleen Hansen, Rosemary Peternel and George A. Bray -- I. Epidemiology And Clinical Treatment: Issues In Defining And Treating The Metabolic Syndrome -- Metabolic Syndrome : To Be or Not to Be? / Gerald M. Reaven -- The Role of Obesity in Insulin Resistance : Epidemiological and Metabolic Aspects / James B. Meigs -- Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery / George A. Bray -- Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease : An Epidemiological Perspective / Earl S. Ford and Simin Liu -- The Sympatho-Adrenal System in the Metabolic Syndrome / Lewis Landsberg -- II. Endothelial Function, Inflammation, and Dyslipidemia -- Insulin Action and Endothelial Function / Kieren J. Mather, Alain Baron and Michael J. Quon -- Macro- and Microvascular Disease in an Insulin-Resistant Pre-Diabetic Animal Model : The JCR:LA-cp Rat / James C. Russell and Spencer D. Proctor -- High-Sensitivity C-Reactive Protein and the Metabolic Syndrome / Yiqing Song, Simin Liu and Joann E. Manson -- Insulin Signaling in Adipocytes and the Role of Inflammation / Christian X. Andersson, Ann Hammarstedt, Per-Anders Jansson and Ulf Smith -- Insulin Resistance and Dyslipidemia / Tina J. Chahil, Gissette Reyes and Henry N. Ginsberg -- III. Insulin - Secretion and Action: Underlying Mechanisms of the Metabolic Syndrome -- Pancreatic Islet Pathophysiology and Pathology in Obesity / Anne Clark, Jenni Moffitt, Lianne Van De Laar, Katherine Pinnick and Farhina Sayyed -- Glucagon-like Peptides and Insulin Sensitivity / Jens Juul Holst and Filip Krag Knop -- The Relationship Between the Insulin Receptor Substrates and Metabolic Disease / Morris F. White -- Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase / Jack F. Youngren -- Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance : An Update / E. W. Kraegen, G. J. Cooney, Jiming M. Ye and Stuart M. Furler -- Alterations in Atypical Protein Kinase C Activation in Insulin Resistance Syndromes / Robert V. Farese -- The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus / Jerry Radziuk and Susan Pye -- Chronomics of the Metabolic Syndrome / Barbara Caleen Hansen.
- Metabolic syndrome in clinical practice 2008Springer
- Metabolic syndrome pharmacology and clinical aspects 2013SpringerMetabolic syndrome is a common syndrome affecting about 20% of the adult population in Europe, and the prevalence is likely similar in other industrialised countries worldwide. It is mainly caused by the western lifestyle, which tends to produce abdominal obesity, but a genetic predisposition also plays a part. This syndrome, which is linked to leisure lifestyles and overeating/obesity, can develop into type 2 diabetes, cardiovascular disease and cancer. Therefore, proper treatment and prevention are essential. This book discusses lifestyle intervention and treatment, specifically with pharmacological compounds, in order to formulate a strategy for treating the metabolic syndrome in daily practice.
- Metabolism and disease 2011Cold Spring Harb Lab Press"The Symposium aimed to integrate a very broad field of investigative effort, bringing together advances in our understanding of energy intake, consumption, and storage (diet, exercise, and fat), oxygen regulation and hypoxia, circadian rhythms, and life span/aging. The Symposium explored metabolism at molecular (gene expression, posttranslational modifications, protein turnover, cofactors and integrators, hormones, and signals), organellar (mitochondria), cellular, organ system (cardiovascular, bone), and organismal (timing and life span) scales. Diseases impacted by metabolic imbalance or dysregulation that were covered in detail included diabetes, obesity, metabolic syndrome, and cancer. New and emerging technologies were presented for simultaneous monitoring of hundreds of metabolites that allow for sophisticated sampling of the metabolic state of cells. Because the Symposium covered such a broad field, by necessity much excellent work could not be included, and instead, the Proceedings should be viewed as a necessarily eclectic collection of some of the most interesting and stimulating work that came to the organizers' attention during the 18 months before the meeting"--P. XV.
- Metabolome analyses strategies for systems biology 2005SpringerIntroduction / Seetharaman Vaidyanathan, George G. Harrigan and Royston Goodacre -- Towards integrative functional genomics using yeast as a reference model / Juan I. Castrillo and Stephen G. Oliver -- Metabolomics for the assessment of functional diversity and quality traits in plants / Robert D. Hall ... [et al.] -- Metabolomics: a new approach towards identifying biomarkers and therapeutic targets in cns disorders / Rima Kaddurah-Daouk ... [et al.] -- Compaative metabolome profiling using two dimensional thin layer chromatography (2DTLC) / Thomas Ferenci and Ram Maharjan -- Capillary electrophoresis and its application in metabolome analysis / Li Jia and Shigeru Terabe -- Metabolic networks / Eivind Almaas, Zoltán N. Oltvai and Albert-László Barabási -- Metabolic networks from a systems perspective / Wolfran Weckwerth, Ralf Steuer -- Parallel metabolite and trascript profiling / Alisdair R. Fernie, Ewa Urbanczyk-Wochniak and Lothar Willmitzer -- Fluxome profiling in microbes / Nicola Zamboni and Uwe Sauer -- Targeted drug design and metabolic pathway flux / László G. Boros and Wai-Nang Paul Lee -- Metabonomics in the pharmaceutical industry / Eva M. Lenz, Rebecca Williams and Ian D. Wilson -- How lipidomic approaches will benefit the pharmaceutical industry / Alvin Berger -- Metabolites and fungal virulence / Edward M. Driggers and Axel A. Brakhage. Metabolite profiling with GC-MS and LC-MS / Ralf Looser, Arno J. Krotzky, Richard N. Trethewey -- The application of electrochemistry to metabolic profiling / David F. Meyer, Paul H. Gamache and Ian N. Acworth -- Differential metabolic profiling for biomarker discovery / Haihong Zhou, Aaron B. Kantor and Christopher H. Becker -- NMR-based metabonomics in toxicology research / Laura K. Schnackenberg, Richard D. Beger, and Yvonne P. Dragan -- Methodological issues and experimental design considerations in metabolic profile-based classifications / Bruce S. Kristal ... [et al.] -- Modelling of fungal metabolism / Helga David and Jens Nielsen -- Detailed kinetic models using metabolomics data sets / Jacky L. Snoep, Johann M. Rohwer --
- Metabolomics methods and protocols 2006Springer ProtocolsMetabolite profiling in blood plasma / Oliver Fiehn and Tobias Kind -- Nonsupervised construction and application of mass spectral and retention time index libraries from time-of-flight GC/MS metabolite profiles / Alexander Erban ... [et al.] -- Metabolomic profiling of natural volatiles: head space trapping-GC/MS / Yury M. Tikunov, Francel W. A. Verstappen, and Robert D. Hall -- Integrative profiling of metabolites and proteins: improving pattern recognition and biomarker selection for systems-level approaches / Katja Morgenthal ... [et al.] -- Integrating profiling data: using linear correlation to reveal coregulation of transcript and metabolites / Ewa Urbanczyk-Wochniak, Lothar Willmitzer, and Alisdair R. Fernie -- Visualization and analysis of molecular data / Matthias Scholz and Joachim Selbig -- A gentle guide to the analysis of metabolomic data / Ralf Steuer ... [et al.] -- CE-MS for metabolomics / Tomoyoshi Soga -- Application of LC/MS analysis in metabolomics: reversed-phase monolithic capillary chromatography and hydrophilic chromatography coupled to electrospray ionization mass spectrometry / Vladimir V. Tolstikov, Oliver Fiehn, and Nobuo Tanaka -- HPLC-separations coupled with coulometric-electrode array detectors: a unique approach to metabolomics / Bruce S. Kristal ... [et al.] -- Determination of metabolic flux ratios from 13C-experiments and GC/MS data: protocol and principles / Annik Nanchen, Tobias Fuhrer, and Uwe Sauer -- Understanding the roadmap of metabolism by pathway analysis / Stefan Schuster, Axel von Kamp, and Mikhail Pachkov -- Revealing the metabolome of animal tissues using 1H NMR spectroscopy / Mark R. Viant -- NMR metabonomics: methods for drug discovery and development / Karl-Heinz Ott and Nelly Aranibar.
- Meyler's Side effects of endocrine and metabolic drugs 2009ClinicalKeyCorticosteroids and related drugs -- Prostaglandins -- Sex hormones and related drugs -- Iodine and drugs that affect thyroid function -- Insulins and other hypoglycemic drugs -- Other hormones and related drugs -- Lipid-regulating drugs -- Endocrine and metabolic adverse effects of non-hormonal and non-metabolic drugs.
- "The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host ("us"). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease"--Publisher's description.
- The second edition of Minimally Invasive Bariatric Surgery provides a comprehensive, state-of-the art review of this field, and it serves as a valuable resource for clinicians, surgeons and researchers with an interest in minimally invasive bariatric surgery. Additionally, the second edition includes new features that will benefit the resident, fellow, or bariatric surgeon new to the field. Specifically, each evidence-based chapter (i.e. outcomes, complications, epidemiology, etc) concludes with three or four exam questions that emphasize the salient points of the chapter and provide fellowship programs a valuable training tool and resource for their academic curriculum. These questions are either single-answer multiple choice or true/false format and the correct response with a brief explanation follows. As more emphasis is placed on completing a comprehensive curriculum and obtaining certification for bariatric training, this aspect of the book is unique and provides added value to the text. The new edition also incorporates many new or updated medical illustrations to enhance the technique chapters and provide more uniformity for the artwork throughout the book. Each of the major procedures include surgical technique, outcomes, and management of complications in separate chapters to provide an easy reference for the busy clinician preparing for a case or presentation. Another unique feature of the text is a link to video files hosted online for the relevant chapters. This video library will be of great value to the user. As the number of fellowships in laparoscopic bariatric surgery continues to increase, this updated text will provide a valuable resource for general and bariatric surgeons, laparoscopic surgeons, fellows, residents, medical students, obesity researchers, and industry representatives involved in this field. Minimally Invasive Bariatric Surgery is a valuable resource for Medical students, surgical oncology fellows, general surgeons, and educators.
- Modeling metabolism with Mathematica detailed examples including human erythrocyte metabolism 2003CRCnetBASE
- Molecular and cellular iron transport 2002CRCnetBASEI. Molecular Aspects of Iron Transport -- 1. Iron Chemistry / Wesley R. Harris -- 2. Transferrins / Ross T. A. MacGillivray and Anne B. Mason -- 3. The Transferrin Receptor / Caroline A. Enns -- 4. Molecular Aspects of Release of Iron from Transferrin / Qing-Yu He and Anne B. Mason -- 5. Ferritins: Structural and Functional Aspects / Paolo Arosio and Sonia Levi -- 6. The Divalent Metal-Ion Transporter (DCT1/DMT1/Nramp2) / Hiromi Gunshin and Matthias A. Hediger -- 7. Basolateral Transport of Iron in Mammalian Intestine: From Physiology to Molecules / Andrew T McKie and Robert J. Simpson -- 8. HFE / Robert E. Fleming, Robert S. Britton, Abdul Waheed, William S. Sly, and Bruce R. Bacon -- 9. Regulation of Iron Homeostasis by Iron Regulatory Proteins 1 and 2 / Eric S. Hanson and Elizabeth A. Leibold -- 10. Iron-Response Element (IRE) Structure and Combinatorial RNA Regulation / Hans E. Johansson and Elizabeth C. Theil -- 11. Frataxin and Mitochondrial Iron / Pierre Rustin -- 12. Siderophore Chemistry / Alain Stintzi and Kenneth N. Raymond -- 13. Iron Chelator Chemistry / Zu D. Liu and Robert C. Hider -- II. Cellular Iron Transport -- 14. Iron Acquisition in Plants / Elizabeth E. Rogers and Mary Lou Guerinot -- 15. Iron Uptake in Yeast / Orly Ardon, Jerry Kaplan, and Brooke D. Martin -- 16. Bacterial Iron Transport / Volkmar Braun and Klaus Hantke -- 17. Uptake of Transferrin-Bound Iron by Mammalian Cells / Deborah Trinder and Evan Morgan -- 18. Transport of Non-Transferrin-Bound Iron by Hepatocytes / Joel G. Parkes and Douglas M. Templeton -- 19. Iron Acquisition by the Reticuloendothelial System / Günter Weiss -- 20. Iron Transport in the Central Nervous System / Joseph R. Burdo and James R. Connor -- 21. Iron Uptake by Neoplastic Cells / Des R. Richardson -- 22. Novel Methods for Assessing Transport of Iron Across Biological Membranes / Z. Ioav Cabantchik, Silvina Epsztejn, and William Breuer -- III. Physiology of Iron Transport -- 23. Regulation of Intestinal Iron Transport / Gregory J. Anderson and Christopher D. Vulpe -- 24. Regulation of Systemic Iron Transport and Storage / Pierre Brissot, Christelle Pigeon, and Olivier Loréal -- 25. Regulation of Liver Iron Metabolism / Gaetano Cairo -- 26. Iron Utilization in Erythrocyte Formation and Hemoglobin Synthesis / Prem Ponka --IV. Disorders of Iron Transport -- 27. Animal Models of Iron Transport and Storage Disorders / Nancy C. Andrews -- 28. Hemochromatosis: Diagnosis and Management Following the Discovery of the Gene / Paul C. Adams -- 29. Transfusional Iron Overload / Nancy F Olivieri -- 30. Aceruloplasminemia / Nathan E. Hellman and Z. Leah Harris -- 31. Hereditary Hyperferritinemia Cataract Syndrome / Carole Beaumont and Domenico Girelli -- 32. Other Disorders of Increased Iron Absorption: Iron Overload in Africans and African Americans / Fitzroy W. Dawkins and Victor R. Gordeuk -- 33. Iron Chelation / Chaim Hershko, Gabriela Link, and Avraham M. Konijn.
- Historical perspective on the genetic forms of congenital hyperinsulinism / Stanley, C.A., Matschinsky, F.M. -- Biochemistry and physiology of the ATP-sensitive potassium channel / Remedi, M.S., Nichols, C.G. -- Pathophysiology of diffuse ATP-sensitive potassium hyperinsulinism / De León, D.D., Stanley, C.A. -- Molecular defects of ATP-sensitive potassium channels in congenital hyperinsulinism / Shyng, S.-L. ... [et al.] -- Molecular mechanisms and clinical pathophysiologies of focal ATP-sensitive potassium hyperinsulinism and Beckwith-Wiedemann Syndrome / Arnoux, J.-B. ... [et al.] -- Pancreatic histopathology of hyperinsulinism / Suchi, M., Bhatti, T.R., Ruchelli, E.D. -- Localization of a focal lesion of congenital hyperinsulinism : imaging and surgery / States, L.J., Adzick, N.S. -- Role of incretin hormones in hyperinsulinemic hypoglycemia / De León, D.D. -- Glutamate dehydrogenase : structure, regulation, and its role in insulin homeostasis / Smith, T.J. -- Congenital hyperinsulinism due to activating mutations of glutamate dehydrogenase : the hyperinsulinism/hyperammonemia syndrome / Kelly, A., Palladino, A., Stanley, C.A. -- Amino acid-stimulated insulin secretion : the role of the glutamine-glutamate-alpha-ketoglutarate axis / Li, C., Matschinsky, F.M., Stanley, C.A. -- Tissue specificity of glutamate dehydrogenase as illustrated in pancreatic beta-cells and the central nervous system / Carobbio, S. ... [et al.] -- The molecular genetics and pathophysiology of congenital hyperinsulinism caused by short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency / Molven, A. ... [et al.] -- Hyperinsulinism due to activating mutations of glucokinase / Sayed, S., Matschinsky, F., Stanley, C.A. -- Hyperinsulinism due to mutations of uncoupling protein 2 / Del Mar Gonzalez-Barroso, M., de Lonlay, P., Ricquier, D. -- Exercise-induced hyperinsulinism : a failure of monocarboxylate transporter 1 expression silencing / Otonkoski, T., Meissner, T. -- HNF4A and hyperinsulinemic hypoglycemia / Kapoor, R.R., James, C.T., Hussain, K.
- As the worldwide prevalence of morbid obesity among adolescents continues to rise, recent years have seen a large increase in the performance of adolescent bariatric surgery. While surgical intervention often becomes necessary when conservative weight-loss therapies have failed, no standards regarding the post-operative regimen and long-term management of adolescent patients have been established. Thus, the treatment of obesity and its co-morbidities requires a multidisciplinary approach, taking into account epidemiological, clinical, nutritional, and genetic aspects of morbid obesity in the pediatric age group. This volume discusses both conventional therapy and surgical options for morbid obesity in the pediatric age group. In the first part, obesity-related diseases, genetics, and psychological factors are analyzed. The second part focuses on current bariatric surgery procedures, including dietary restrictions and guidelines to prevent nutritional deficiencies common after surgery. Therefore, the book will prove an invaluable resource for pediatricians, surgeons, nutritionists, dieticians, and all other health professionals who treat adolescent obesity.
- This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options, and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.
- Murine models, energy balance, and cancer 2015SpringerThis volume provides a transdisciplinary and translational review of many of the leading murine models used to study the mechanisms, mediators and biomarkers linking energy balance to cancer. It provides a review of murine models that should be of interest to basic, clinical and applied research investigators as well as nutrition scientists and students that work in cancer prevention, cancer control and treatment. The worldwide obesity pandemic has been extensively studied by epidemiologic and observational studies and even, in some cases, by randomized controlled trials. However, the development and control of obesity, its comorbidities and its impact on cancer usually occurs over such long periods that it is difficult, if not impossible to conduct randomized controlled trials in humans to investigate environmental contributions to obesity, energy balance and their impact on cancer. In contrast, model organisms, especially mice and rats, provide valuable assets for performing these studies under rigorously controlled conditions and in sufficient numbers to provide statistically significant results. In this volume, many of the leading and new murine models used to study the mechanisms and mediators linking cancer with obesity, sleep, exercise, their modification by environment and how they may continue to be used to further elucidate these relations as well as to explore preclinical aspects of prevention and/or therapeutic intervention are considered. This volume provides an important compilation and analysis of major experimental systems and principles for further preclinical research with translational impact on energy balance and cancer.
- Muscle metabolism 2002CRCnetBASEPerspectives / Eleazar Shafrir -- I. Insulin Signaling -- 1. Overview: Tyrosine Kinase Signaling in Insulin Action / Martin G. Myers, Jr. -- 2. Defects in Early Insulin Signaling in Skeletal Muscle / M. Dodson Michael and C. Ronald Kahn -- 3. Defects in Intermediate Insulin Signaling in Skeletal Muscle: Phosphatidylinositol (PI) 3-kinase and Glucose Transport / Francesco Giorgino -- II. Glucose Transport -- 4. Glucose Transport in Muscle / John O. Holloszy and Lorraine A. Nolte -- 5. The GLUT4 Compartments of Skeletal Muscle / Toolsie Ramlal, Peter Tong, Tony Lam, Romel Somwar, Maureen Charron and Amira Klip -- III. Substrate Utilization -- 6. Adverse Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications for the Pathogenesis of Diabetes Mellitus / Donald A. McClain -- 7. Cellular Mediators of Glucose-Induced Autoregulation of Hexose Transport / Evgenia Alpert, Hanan Totary and Shlomo Sasson -- 8. Physiological Adaptations in Glucose Utilization of Skeletal Muscle / Julian M.R. Mathoo and Mladen Vranic -- 9. Fatty Acids and Muscle Insulin Resistance / Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Alison L. Thompson and Stuart M. Furler -- 10. Role of AMP Kinase and Malonyl CoA in Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action / David J. Dean and Neil B. Ruderman -- IV. Transgenic and Genetic Models -- 11. The Use of Mouse Transgenic and Homologous Recombination.
- Neural metabolism in vivo 2012SpringerIntroduction to Nuclear Magnetic Resonance (NMR) Methods / Allen W. Song -- Hardware Requirements for In Vivo Nuclear Magnetic Resonance Studies of Neural Metabolism / Hellmut Merkle, Phil Lee and In-Young Choi -- Diffusion Sensitive Magnetic Resonance Imaging of the Central Nervous System / Jeffrey J. Neil and Joseph J. H. Ackerman -- Tools to Enhance the Contrast in MR Images: From Lanthanide Complexes and Iron Oxide Particles to MEMRI / Annemie Van der Linden, Vincent Van Meir, Dario Longo and Silvio Aime -- Principles of 1H NMR Spectroscopy In Vivo / Robin A. de Graaf -- In Vivo Cerebral 31P Magnetic Resonance Spectroscopy / Ernest B. Cady -- In Vivo13C Magnetic Resonance Spectroscopy and Metabolic Modeling: Methodology / Pierre-Gilles Henry, Dinesh K. Deelchand, Isabelle Iltis, Malgorzata Marjanska and Gülin Öz, et al. -- 13C NMR Spectroscopy as a Tool in Neurobiology / Asta Haberg, Ursula Sonnewald, Janniche Hammer, Torun Melø and Haytham Eloqayli -- Overview of Positron Emission Tomography (PET) and Single Photon Emission Computed Tomography (SPECT) Methodologies / Paul Cumming and Guido Böning -- Fluorodeoxyglucose (FDG) Positron Emission Tomography (PET) / Andrei G. Vlassenko and Mark A. Mintun -- Neuroreceptor Imaging / Habib Zaidi and Miho Shidahara -- Optical Approaches to Study Metabolic Consequences of Spreading Depression In Vivo / C. William Shuttleworth -- Microdialysis and Microfiltration: Technology and Cerebral Applications for Energy Substrates / Kirsten Huinink, Jakob Korf and Jan Bert Gramsbergen -- Part 2. In vivo assessment of neural activity via neurovascular coupling / The Coupling of Cerebral Metabolic Rate of Glucose and Cerebral Blood Flow In Vivo / Steen G. Hasselbalch and Olaf B. Paulson -- Neuronal Basis of Non-Invasive Functional Imaging: From Microscopic Neurovascular Dynamics to BOLD fMRI / Anna Devor, David A. Boas, Gaute T. Einevoll, Richard B. Buxton and Anders M. Dale -- Imaging of Brain Function Using Deoxyhemoglobin and Magnetic Fields / Kâmil Uğurbil -- FMRI Using Exogenous Agents and Cerebral Blood Volume Contrast / Joseph B. Mandeville. FMRI in Mice: Functional Phenotyping of Transgenic Mouse Lines Based on Hemodynamic Readouts / Thomas Mueggler, Christof Baltes, Simone C. Bosshard, Felicitas L. Princz-Kranz and David Ratering, et al. -- In Vivo Studies of Brain Oxygen Metabolism and Oxidative Phosphorylation / Xiao-Hong Zhu and Wei Chen -- Cerebral Glucose Transport and Homeostasis / João M. N. Duarte and Rolf Gruetter -- Glucose Metabolism During Neural Activation / Marianne Fillenz -- Measurements of Glycogen Metabolism in the Living Brain / Rolf Gruetter -- Functions of Glycogen in the Central Nervous System / Richard D. Evans, Angus M. Brown and Bruce R. Ransom -- Pyruvate Transport and Metabolism in the Central Nervous System / Tiago B. Rodrigues, Alejandra Sierra, Paloma Ballesteros and Sebastián Cerdán -- Blood-Brain Barrier Transport of Lactate / Gitte Moos Knudsen -- Cerebral Acetate Metabolism: Towards Its In Vivo Assessment / Basil Künnecke -- Brain Fatty Acid Uptake / James A. Hamilton, Kellen Brunaldi, Richard P. Bazinet and Paul A. Watkins -- The Ketogenic Diet and Brain Metabolism / Marc Yudkoff, Yevgeny Daikhin, Oksana Horyn, Ilana Nissim and Itzhak Nissim -- Redox Shuttles in the Brain / Beatriz Pardo and Laura Contreras -- Mitochondria in Neurodegeneration / Russell H. Swerdlow -- Part 4. In vivo assessment of metabolic compartmentation between neurons and astrocytes / Studies of Brain Metabolism: A Historical Perspective / Arne Schousboe -- Glutamate-Glutamine Cycle and Anaplerosis / Gülin Öz, David A. Okar and Pierre-Gilles Henry -- Brain Metabolic Compartmentalization, Metabolism Modeling, and Cerebral Activity-Metabolism Relationship / Michel Merle and Jean-Michel Franconi -- Radiotracer Perspective on Cerebral Compartmentation / Bruno Weber, Renaud Jolivet, Matthias T. Wyss and Alfred Buck -- Nitrogen Metabolism In Vivo / Keiko Kanamori and Brian D. Ross -- Part 5. Cerebral metabolism of antioxidants, osmolytes and others in vivo / Glutathione (GSH) Synthesis and Metabolism / Maike M. Schmidt and Ralf Dringen -- Brain Ascorbate: Protective, Yet Permissive for Redox Signaling / Margaret E. Rice -- N-Acetyl-Aspartate (NAA) Metabolism / Kishore K. Bhakoo -- In Vivo GABA Metabolism / In-Young Choi and Jun Shen -- 1H-Magnetic Resonance Spectroscopy of Cerebral Phenylalanine Content and its Transport at the Blood-Brain Barrier / Roland Kreis -- Measurement of Brain Creatine Metabolism In Vivo: Magnetic Resonance Spectroscopy Studies of Transgenic Animals / Arend Heerschap, Christine I. H. C. Nabuurs, Hermien E. Kan, Bé Wieringa and Dirk Isbrandt.
- Neurons and the DHA principle 2013CRCnetBASENature of neurons and their specialized membranes -- DHA contributes both benefits and risks to mammals -- Use it or lose it concept of brain health is linked to DHA -- Evolution and DHA : redefining the DHA principle -- DHA is king omega for maximizing mental speed -- DHA improves energy efficiency in neurons -- Wild conformational dynamics of DHA might save energy by sealing stretch-induced defects as fast as they occur in membranes -- Lipid whisker model and water-wire theory of energy uncoupling in neurons -- Neurons boost their energy state by using powerful antioxidant systems to protect their membranes against damage -- Oxygen-dependent damage (lipid peroxidation) of DHA membranes of neurons is inevitable and requires novel mechanisms for long-term protection -- Revised mitochondrial theory of aging and brain span -- Development of dual energy pacemaker theory of aging : role of the membrane -- Membranes and cancer -- Parkinson's disease -- Prion diseases -- Brain trauma-induced dementia -- Alzheimer's disease.
- New frontiers in lifestyle-related diseases 2008Springer
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- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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