Books by Subject
- Abdominal obesity--a driver of cardiometabolic risk — Identification and characterization of a novel polyubiquitin binding protein involved in virus maturation (100)
- IgE antibody dynamics and its role in receptor binding and inhibition — Physician's guide to the diagnosis, treatment, and follow-up of inherited metabolic diseases (100)
- Physician's guide to the treatment and follow-up of metabolic diseases — Yeast metabolic engineering : methods and protocols (51)
- 2006 HighWireJean-Pierre Després ... [et al.].
- 2013David Bochner.Neural plasticity is high during developmental critical periods, then declines by adulthood. Here by acutely disrupting PirB function at different ages, we show that Paired immunoglobulin like receptor B (PirB) actively restricts plasticity both during and after the critical periopd. Chapter 1 introduces ocular dominance (OD) plasticity as a model of circuit and synaptic change, and presents a review of the literature on the study of mechanisms of OD plasticity, critical period timing, and manipulations that can alter plasticity later in life. Chapter 2 presents an overview of the methodological approaches used. PirB function was disrupted with temporal precision via either a conditional PirB allele or by minipump infusion of a soluble PirB ectodomain into mouse visual cortex. Chapter 3 details the effects of disrupting PirB function on plasticity in healthy animals. OD plasticity is enhanced not only during the critical period, but also when PirB function is disrupted in adulthood. The effects of adult deletion can occur even when PirB is only lost in excitatory neurons of the forebrain. Acute blockade of PirB for 10 days after the close of the critical period increases spine density on apical and basolateral dendrites of Layer 5 pyramidal neurons. Chapter 4 presents a proof of concept for therapeutic disruption of PirB function in cases of neurological dysfunction and disease. Long term monocular deprivation (LTMD) during the critical period leads to a lasting loss of vision in the deprived eye and to a decrease in dendritic spine density that does not recover even with subsequent binocular vision. However, acute blockade of PirB following LTMD allows for full recovery of spine density. MeCP2308/y mice, a mouse model of Rett Syndrome (a syndromic autism), were found to have increased MHC Class I expression and a concurrent loss of OD plasticity during the critical period, which can be rescued by acute blockade of PirB. Taken together, these results imply that mechanisms for enhanced structural and functional plasticity are present in adult visual cortex but are actively repressed by PirB. By removing negative regulators such as PirB, we show that it is possible to engage these endogenous mechanisms to facilitate recovery from otherwise irreversible effects of dysfunctional development. Our observations suggest that similar manipulations may be useful in other situations where restoring synaptic plasticity and increasing spine density have therapeutic value.
- v.1-3=, 2008-2015 Springer Protocolsv.2 (2010) Springer Protocolsv.3 (2015) Springer Protocolsedited by Donald Armstrong.
- 2013 SpringerJerome D. Williams, Keryn E. Pasch, Chiquita A. Collins, editors.Overview, The IOM Report, and Integrated Marketing Communications -- Introduction: Childhood Obesity: Media, Advertising, Community, and Advocacy -- Progress on Public Policy: The Aftermath of the 2005 Institute of Medicine Report on Food Marketing and the Diets of Children and Youth -- Integrated Marketing Communications and Power Imbalance: The Strategic Nature of Marketing to Children and Adolescents by Food and Beverage Companies -- Legal, Ethical, and Policy Implications of Advertising -- The Role of Ethics in Food and Beverage Marketing to Children -- The New First Amendment and Its Implications for Combating Obesity Through Regulation of Advertising -- Self-regulation as a Tool for Promoting Healthier Children's Diets: Can CARU and the CFBAI Do More? -- Monitoring Food Company Marketing to Children to Spotlight Best and Worst Practices -- Measuring the Impact of Advertising Effects -- Children's Exposure to Food and Beverage Advertising on Television: Tracking Calories and Nutritional Content by Company Membership in Self-regulation -- The Role of Advertising on Attitudes and Consumption of Food and Beverage Products -- The Digital Food Marketing Landscape: Challenges for Researchers -- A Multi-Method Study to Understand How Youth Perceive and Evaluate Food and Beverage Advertisements -- A Global Perspective of Food Marketing and the Role of Place -- Adolescents' Response to Food Marketing in Delhi, India -- The Role of Schools in Food and Beverage Marketing: Significance, Challenges, Next Steps -- Outdoor Food and Beverage Advertising: A Saturated Environment -- Exploring Marketing Targeted at Youth in Food Stores -- Racial/Ethnic Minorities and Community Empowerment -- Understanding Community Perspectives: A Step Towards Achieving Food Marketing Equity -- Latino Youth and Obesity: Communication/Media Influence on Marketing -- Targeted Marketing of Junk Food to Ethnic Minority Youth: Fighting Back with Legal Advocacy and Community Engagement -- Communicating About Physical Activity -- Physical Activity, Media, and Marketing: Advances in Communications and Media Marketing -- Communities Leveraging the Assets of a National Social Marketing Campaign: Experiences with VERB[TM]. It's What You Do! -- Development and Release of the 2008 Physical Activity Guidelines for Americans: Children and Adolescents -- Thinking Outside the Box: Finding Solutions to Reverse Childhood Obesity -- Voluntary Health Organizations and Nonprofit Advocacy Organizations Play Critical Roles in Making Community Norms More Supportive of Healthier Eating and Increased Physical Activity -- Childhood Obesity and Exergames: Assessments and Experiences from Singapore -- Leveraging Industry Efforts to Fight Childhood Obesity: A Multi-Sectored Approach to Communications.
- 2006 SpringerKoki Horikoshi.
- 2015 SpringerJozef Rovenský, Tibor Urbánek, Boldišová Olʹga, James A. Gallagher, editors.This book comprehensively describes alkaptonuria and ochronosis. Beginning with the history, genetics, pathophysiology and diagnostics of the disease, the authors subsequently present a detailed characterization of its clinical manifestation in the spine, peripheral joints, eyes, ears, visceral organs and respiratory tract, its pathological anatomy and histology, as well as differential diagnosis. This is complemented by the latest data on therapy and experimental models of alkaptonuria, and supported by several case reports. Numerous pictures and radiological images document the clinical symptoms, giving the reader a solid understanding of the disease. On the basis of the editor?s and authors? own extensive observations, the book offers an analysis of protein metabolism and aromatic amino acids in the context of alkaptonuria. Written by international experts in the field, the book offers a valuable reference guide for healthcare professionals working in rheumatology, dermatology, pulmonology, otolaryngology and histopathology.
- Always hungry? : conquer cravings, retrain your fat cells, and lose weight permanently. First edition [1st ed.].2016David Ludwig, MD, PhD."Inspired by the New York Times op-ed "Always Hungry," ALWAYS HUNGRY? will change everything readers ever thought about weight loss, diet, and health. Groundbreaking new research shows that calorie counting does not work for weight loss: one diet causes weight gain whereas another diet with the same calorie count doesn't. It's your fat cells that are to blame for causing excessive hunger and increased weight. By eating the wrong foods, our fat cells are triggered to take in too many calories for themselves, setting off a dangerous chain reaction of increased appetite and a slower metabolism. Now, Harvard Medical School's David Ludwig, MD, PhD, offers an impeccably researched diet that will turn dieting on its head, teaching readers to reprogram their fat cells, tame hunger, boost metabolism, and lose weight--for good"-- Provided by publisher.
- 2007 Springervolume editor, Volker F. Wendisch.
- Amyloid and related disorders : surgical pathology and clinical correlations. Second edition [2nd ed.].2015 SpringerMaria M. Picken, Ahmet Dogan, Guillermo A. Herrera, editors.
- 2012 SpringerMaria M. Picken, Ahmet Dogan, Guillermo A. Herrera, editors.Abnormal proteins are known to be associated with various pathologies. Most notably, these include amyloidoses, monoclonal protein deposits associated with plasma cell dyscrasia/multiple myeloma, cryoglobulins and various related organized and non-organized deposits. Amyloid and Related Disorders presents an overview of the most recent developments in this area including clinical presentation, etiology, pathogenesis, and differential diagnosis. The rationale for various therapies, including transplantation, is discussed and tissue diagnosis (its pitfalls and strategies for avoiding them) and laboratory support are included. The involvement of all major organ systems including renal/genitourinary, cardiac, gastrointestinal, pulmonary, peripheral nerve/central nervous system, soft tissue and bone marrow pathology is covered. This approach provides a unifying concept of these pathologic processes, which have systemic involvement, and which have, hitherto, not been universally appreciated. Awareness of these diseases among a wider audience of pathologists may increase the rate of their diagnosis as well as that of earlier diagnosis. This volume will be invaluable to specialized and general pathologists as well as cytopathologists; other medical professionals may also benefit from this concise update on the systemic amyloidoses.
- 2015 SpringerJ. de Graaf, P. Couture and A.D. Sniderman.1. The life history of ApoB lipoprotein particles -- 2. Diagnosis of the ApoB dyslipoproteinemias: the ApoB algorithm -- 3. The primary ApoB dyslipoproteinemias -- 4. Secondary ApoB dyslipoproteinemias -- 5. ApoB in cardiovascular risk prediction -- 6. ApoB lipoprotein particles: the preferred treatment target in primary and secondary prevention -- 7. The future of ApoB: moving from the risk prediction paradigm to the casual exposure paradigm.
- 2012 SpringerHans-Georg Joost, editor.The volume Appetite Control provides a comprehensive description of the mechanisms controlling food intake, and thereby energy balance, in the mammalian organism. During the last decade, research in this area has produced a remarkable wealth of information and has characterized the function of numerous peptides, transmitters, and receptors in appetite control. Dysfunction of these circuits leads to obesity, a growing health concern. However, the plethora of mechanistic information is in marked contrasts to an almost complete lack of anti-obesity drugs that meet the safety standards required for the chronic therapy of morbid obesity. Consequently, ongoing research aims to identify additional targets and agents for a pharmacological intervention. Thus, the mechanisms of appetite control as well as all agents interfering with its control are of considerable practical interest.The authors of the volume are distinguished scientists who are leading experts in the field, and who have contributed important, original data to our understanding of the mechanisms of appetite control. They have quite different scientific backgrounds and, together, they represent all relevant disciplines. Thereby, the topics are presented from different points of view, not exclusively from that of pharmacology and neuroendocrinology. Thus, the volume addresses all scientists who are interested in the field of obesity research and the pathophysiology of appetite control.
- 2012Jae Mo Park.Unlike normal tissues, solid tumors have a metabolic phenotype that favors energy-inefficient glycolysis rather than more efficient, but oxygen consuming, oxidative phosphorylation, even when oxygen levels are adequate. This metabolic shift towards glycolysis, discovered by Warburg in 1924, has been studied for more than 80 years, but the mechanism of the phenomena is still unclear due to lack of tools for in vivo investigation. Dynamic nuclear polarization in combination with the recent development of a dissolution process that retains the increased polarization into the liquid state opened new possibilities for the real-time investigation of in vivo metabolism using C13 magnetic resonance spectroscopy. In particular, hyperpolarized [1-13C]pyruvate, a substrate occupying a key nodal point in the glucose metabolic pathway, has been successfully demonstrated as a neoplasm biomarker via elevated lactate labeling in tumors. However, additional downstream products of pyruvate metabolism, such as that occur in mitochondria of brain tumor, have been veiled due to low signal-to-noise ratios. The first part of the thesis is on the quantitative assessment of mitochondrial function in normal rat brain and glioma by detecting 13C-bicarbonate following the bolus injection of [1-13C]pyruvate. The feasibility of quantitatively detecting 13C-bicarbonate in tumor-bearing rat brain is demonstrated for the first time. The optimized protocol for chemical shift imaging and high concentration of hyperpolarized [1-13C]pyruvate were used to improve measurements of lactate and bicarbonate in C6 glioma-transplanted rat brains. Moreover, the immediate response to dichloroacetate treatment, which upregulates pyruvate flux to acetyl-CoA, is also presented. It is demonstrated that the simultaneous detection of lactate and bicarbonate provides a tool for a more comprehensive analysis of glioma metabolism and the assessment of metabolic agents as anti-cancer drugs. In the second part of the thesis, further investigation on mitochondrial metabolism, including tricarboxylic acid cycle, is presented by acquiring single-time point chemical shift imaging data from rat brain in vivo after administration of highly concentrated [2-13C]pyruvate. A C13 surface coil optimized for rat brain was built to increase sensitivity of signal detection. [5-13C]glutamate, [1-13C]acetyl carnitine, and [1-13C]citrate were detected besides [2-13C]pyruvate and [2-13C]lactate, for the first time in brain. Change of the tricarboxylic acid cycle activity in brain was also investigated by infusing dichloroacetate. The increase of [5-13C]glutamate was detected primarily from brain, whereas [1-13C]acetyl carnitine was increased in peripheral tissues after the infusion of dichloroacetate. The third part focuses on dynamic measurements of hyperpolarized substrates to obtain exchange rates in addition to concentrations, and proposes the apparent conversion rate as a new metric to detect glioma by comparing the conversion rates in glioma, normal appearing brain, and basilar vasculature in female Sprague-Dawley rats with C6 glioma cells implanted. Whereas single-time point measurements give a snapshot image of tissue metabolism, the estimated apparent rate constant yielded a better differentiation between the tissue types than the lactate-to-pyruvate ratio, which has been the most common metric used to date. This study demonstrates the feasibility of quantitatively detecting C13-labeled bicarbonate and glutamate in vivo, permitting the assessment of dichloroacetate-modulate changes in pyruvate dehydrogenase flux in both normal rat brain and glioma. The simultaneous detection of both lactate dehydrogenase and pyruvate dehydrogenase activities will likely improve our ability to both assess and monitor metabolic therapies of brain and other cancers by providing non-invasive in vivo measures of glycolysis and oxidative phosphorylation.
- 2011 Springereditor, Scott M. Grundy.The Metabolic Syndrome -- Epidemiology of the Metabolic Syndrome and Risk for Cardiovascular Disease and Diabetes -- The Metabolic Syndrome and Atherogenesis -- Triglyceride-Rich Lipoproteins -- High-Density Lipoprotein Metabolism -- Newer Coronary Risk Factors -- Dietary Effects on Cardiovascular Risk Factors -- Strategies for Treating Abnormal Lipid Profiles with Drugs -- Ethnic Differences in the Metabolic Syndrome -- Obesity Management -- Diabetes Mellitus and Cardiovascular Disease -- Gender Differences in Coronary Risk Factors and Risk Interventions.
- 2012 ebrary, Limited to 3 simultaneous usersWilliam L. Nyhan, Bruce A. Barshop, and Aida I. Al-Aqueel.Organic acidemias -- Disorders of amino acid metabolism -- Hyperammonemia and disorders of the urea cycle -- Disorders of fatty acid oxidation -- The lactic acidemias and mitochonrdial disease -- Disorders of carbohydrate metabolism -- Perioxisomal disorders -- Disorders of purine metabolism -- Disorders of transport and mineral metabolism -- Mucopolysaccharidoses -- Mucolipidoses -- Disorders of cholesterol and neutral lipid metabolism -- Lipid storage disorders -- Miscellaneous.
- 2013Xinhong Lim.The skin is a classical example of a tissue maintained by stem cells, but the identity of the stem cells that maintain the different epidermal compartments and the signaling mechanisms that control their activity remain unclear. Using lineage tracing and quantitative clonal analyses, we show that the Wnt-target gene Axin2 marks epidermal stem cells that compete neutrally and require Wnt/[beta]-catenin signaling to proliferate. By RNA in situ hybridization, we show that the Axin2-expressing stem cells produce their own self-renewal signals in the form of Wnt proteins. These cells also express secreted Wnt inhibitors, including Dkks, which accumulate at high levels around more differentiated cells. We propose a new model for skin maintenance, in which epidermal stem cells produce short-range Wnt signals to maintain their own identity and function, while simultaneously secreting longer-range inhibitors that suppress Wnt signaling to promote differentiation of the stem cell progeny.
- 2014 Springeredited by Seung Ho Choi, Kazunori Kasama.Bariatric and metabolic surgery is recognized to be an important and effective option for the treatment of severe obesity and the various associated conditions and diseases, such as type II diabetes, hypertension, cardiovascular dysfunction, dyslipidemia, and obstructive sleep apnea. Despite its established value, however, there is scope for further improvement in safety and in the quality of the surgical techniques, and calls have therefore been made for the establishment of standard techniques and procedures. This book accordingly presents state of the art knowledge on bariatric and metabolic surgery with the aim of facilitating the sharing and exchange of knowledge, documenting effective techniques, and enhancing safety and outcomes. All technical aspects are covered in detail, and the text is complemented by many helpful illustrations. A further key feature is the provision of accompanying surgical videos, which will be of value to both novice and experienced surgeons. This textbook will be a great asset in clinical practice for all who are involved or interested in bariatric and metabolic surgery.
- 2016 SpringerDaniel M. Herron, editor.Introduction and Overview of Current and Emerging Operations.-Anesthesia for the bariatric patient: optimizing safety and managing complications -- Optimizing perioperative management: Perioperative care & protocols to prevent & detect early complications -- Thromboembolic disease in the bariatric patient: Prevention, diagnosis and management -- Hemorrhage after bariatric surgery: evaluation and management -- Enteric Leaks after Gastric Bypass: Prevention and Management -- Enteric Leaks After Sleeve Gastrectomy: Prevention and Management -- Workup of abdominal pain in the gastric bypass and vertical sleeve gastrectomy patient -- Work-up of Abdominal Pain or Vomiting in the Gastric Band Patient -- Internal hernias: prevention, diagnosis & management -- Marginal and Peptic Ulcers: Prevention, Diagnosis, and Management -- Gastrointestinal Obstruction in the Bypass Patient -- Food intolerance in the sleeve patient: prevention, evaluation and management -- Gallstones and Common Bile Duct Stones in the Bariatric Surgery Patient: Surgical and Endoscopic Management -- Management of Abdominal Wall Hernias in the Bariatric Patient -- Band Prolapse: Diagnosis and Management -- Band erosion: surgical and endoscopic management -- Vertical Banded Gastroplasty: Evaluation and Management of Complications -- Inadequate Weight Loss after Bypass and Sleeve -- Failed weight loss after lap band surgery -- Post-Gastric Bypass Hypoglycemia: Diagnosis and Management -- Nutritional complications and emergencies -- Excessive Skin After Massive Weight Loss: Body Contouring and Bariatric Surgery -- The Psychological complications after bariatric surgery (eating disorders, substance abuse, depression, body image, etc.) -- Medical Malpractice in the 21st Century.
- 2007John W. Pelley, Edward F. Goljan.
- 2010John W. Pelley, Edward F. Goljan.Carbohydrates, lipids, and amino acids : metabolic fuels and biosynthetic precursors -- Proteins and enzymes -- Membrane biochemistry and signal transduction -- Nutrition -- Generation of energy from dietary fuels -- Carbohydrate metabolism -- Lipid metabolism -- Nitrogen metabolism -- Integration of metabolism -- Nucleotide synthesis and metabolism -- Organization, synthesis, and repair of DNA -- Gene expression -- DNA technology -- Common laboratory values.
- 2008 SpringerPenefsky, Harvey S.; Schäfer, Günter.Diversity of the heme-copper superfamily in Archaea: insights from genomics and structural modeling / James Hemp, Robert B. Gennis -- Structure of Photosystems I and II / Petra Fromme, Ingo Grotjohann -- Microbial rhodopsins: scaffolds for ion pumps, channels, and sensors / Johann P. Klare, Igor Chizhov, Martin Engelhard -- Life close to the thermodynamic limit: how methanogenic Archaea conserve energy / Uwe Deppenmeier, Volker Müller -- ATP synthesis by decarboxylation phosphorylation / Peter Dimroth, Christoph von Ballmoos -- The three families of respiratory NADH dehydrogenases / Stefan Kerscher ... [et al.] -- Hydrogenases and H+-reduction in primary energy conservation / Paulette M. Vignais -- A structural perspective on mechanism and function of the cytochrome bc1 complex / Carola Hunte ... [et al.] -- Regulatory mechanisms of proton-translocating FoF1-ATP synthase / Boris A Feniouk, Masasuke Yoshida.Also available: Print – 2008
- 2013 ScienceDirectDavid G. Nicholls, Stuart J. Ferguson.Extensively revised, the fourth edition of this highly successful book takes into account the many newly determined protein structures that provide molecular insight into chemiosmotic energy transduction, as well as reviewing the explosive advances in 'mitochondrial physiology'-the role of the mitochondria in the life and death of the cell. Covering mitochondria, bacteria and chloroplasts, the fourth edition of Bioenergetics provides a clear and comprehensive account of the chemiosmotic theory and its many applications. The figures have been carefully designed to be memorable and to convey the key functional and mechanistic information. Written for students and researchers alike, Bioenergetics is the most well-known, current and respected text on chemiosmotic theory and membrane bioenergetics available. Chapters are now divided between three interlocking sections: basic principles, structures and mechanisms, and mitochondrial physiology. Covers new advances in the structure and mechanism of key bioenergetic proteins, including complex I of the respiratory chain and transport proteins.Details cellular bioenergetics, mitochondrial cell biology and signal transduction, and the roles of mitochondria in physiology, disease and aging.Offers readers clear, visual representation of structural concepts through full colour figures throughout the book.
- 2010 SpringerLivio Luzi ; in collaborazione con Roberto Codella ... [et al.].
- 2015 SpringerFilipe Palavra, Flávio Reis, Daniela Marado, Armando Sena, editors.Inflammation biomarkers and cardiometabolic risk -- Cardiovascular disease -- Diabetes mellitus and metabolic syndrome -- Ischemic stroke -- Chronic kidney disease -- Immune-mediated inflammatory rheumatic diseases -- Cardiometabolic risk, inflammation and neurodegenerative disorders.
- 2011 SpringerRobert J. Roselli, Kenneth R. Diller.Part I. Fundamentals of How People Learn (HPL) -- Introduction to HPL Methodology -- Part II. Fundamental Concepts in Biotransport -- Fundamental Concepts in Biotransport -- Modeling and Solving Biotransport Problems -- Part III. Biofluid Transport -- Rheology of Biological Fluids -- Macroscopic Approach for Biofluid Transport -- Shell Balance Approach for One Dimensional Biofluid Transport -- General Microscopic Approach for Biofluid Transport -- Part IV. Bioheat Transport -- Heat Transfer Fundamentals -- Macroscopic Approach to Bioheat Transport -- Shell Balance Approach for 1-D Bioheat Transport -- General Microscopic Approach for Bioheat Transport -- Section V. Biological Mass Transport -- Mass Transfer Fundamentals -- Macroscopic Approach to Biomass Transport -- Shell Balance Approach for 1-D Biomass Transport -- General Microscopic Approach for Biomass Transport.
- 2015 SpringerMieczyslaw Pokorski, editor.The dynamics of body metabolism are changed in the disease process and interact with physical activity. The alteration of metabolism and its consequences raise the need for simple and reliable methods for assessment of body composition. The chapters aim to investigate various interacting components converging on metabolic changes in lung and muscle tissues taking into consideration the drug effects. The effects of exercise and nutritional status are dealt with at a great extent.Also available: Print – 2015
- 2012 SpringerFelix Bronner, Mary C. Farach-Carson, Helmtrud I. Roach, editor[s].Parathyroid Hormone and Parathyroid-Hormone-Related Protein: Normal Function, Diseases, and Emerging Therapeutics / Ling Qin and Nicola C. Partridge -- Vitamin D: Normal Function, Metabolism, Diseases, and Emerging Therapeutics / René St-Arnaud and Marie B. Demay -- Gonadal Hormones, Diseases, and Emerging Therapeutics / Faryal S. Mirza, Liam Zakko and Pamela Taxel -- Thyroid and Thyroid Hormone: Normal Function, Diseases, Disorders, Emerging Therapeutics / Paula H. Stern -- Pituitary Hormones and the Pathophysiology of Osteoporosis / Manasi Agrawal, Shitij Arora, Graziana Colaianni, Li Sun and Jameel Z. Iqbal, [et al.] -- Calcitonin: Its Physiological Role and Emerging Therapeutics / Jillian Cornish, Dorit Naot and T. John Martin -- Glucocorticoids, Inflammation, and Bone / Kong Wah Ng and T. John Martin -- Diseases of Energy and Lipid Metabolism and Bone: Emerging Therapeutics / Sumithra K. Urs and Clifford J. Rosen -- Diseases of Mineral Metabolism and Bone: Emerging Therapeutics for Postmenopausal Osteoporosiss / Paul D. Miller -- Renal Diseases and Bone: Emerging Therapeutics / Nancy S. Krieger and David A. Bushinsky -- Wasting Diseases and Metabolic Impact on Bone: Emerging Therapeutics and Treatment Options / Linda A. DiMeglio -- Paget's Disease of Bone: Pathogenesis and Treatment / Frederick R. Singer and G. David Roodman -- Bone Loss in Space Flight and Countermeasures /; Adrian D. LeBlanc, Elisabeth R. Spector and Victor S. Schneider --; Osteoimmunology: Relation to Disease and Therapy /; M. Neale Weitzmann and Roberto Pacifici -- Bone and the Ear / Kathleen C. Horner -- Bone and the cAMP Signaling Pathway: Emerging Therapeutics / Paul M. Epstein -- Nervous System Diseases, Disorders, and Bone: Emerging Therapeutics and Treatment Options / Mary F. Barbe and Steven N. Popoff.
- 2014 Springer Protocolsedited by Johannes Hirrlinger, Helle S. Waagepetersen.Determination of CO2 Production in Subcellular Preparations like Synaptosomes and Isolated Mitochondria Using 14C-Labeled Substrates and Radioactive CO2 Measurements -- Transport of Lactate: Characterization of the Transporters Involved in Transport at the Plasma Membrane by Heterologous Protein Expression in Xenopus Oocytes -- Primary Cultures of Astrocytes and Neurons as Model Systems to Study the Metabolism and Metabolite Export from Brain Cells -- Metabolic Mapping of Astrocytes and Neurons in Culture Using Stable Isotopes and Gas Chromatography-Mass Spectrometry (GC-MS) -- Metabolic Flux Analysis Tools to Investigate Brain Metabolism In Vitro -- Fluorescent Nanosensor Based Flux Analysis: Overview and the Example of Glucose -- Mitochondrial Bioenergetics Assessed by Functional Fluorescence Dyes -- RNA Interference as a Tool to Selectively Down-Modulate Protein Function -- Localizing and Quantifying Metabolites In Situ with Luminometry: Induced Metabolic Bioluminescence Imaging (imBI) -- A Chip Off the Old Block: The Brain Slice as a Model for Metabolic Studies of Brain Compartmentation and Neuropharmacology -- Integrated Measurements of Electrical Activity, Oxygen Tension, Blood Flow, and Ca2+-Signaling in Rodents In Vivo -- Measuring Cerebral Hemodynamics and Energy Metabolism by Near-Infrared Spectroscopy -- Compartmental Analysis of Metabolism by 13C Magnetic Resonance Spectroscopy -- Positron Emission Tomography of Brain Glucose Metabolism with [18F]Fluorodeoxyglucose in Humans.
- 2012 ClinicalKeyHenry Buchwald ; with illustrations by Michael de la Flor.Section 1. Exposure and closure of the abdomen -- section 2. Primarily malabsorptive procedures -- section 3. Malabsorptive/restrictive procedures : gastric bypass -- section 4. Restrictive procedures -- section 5. Other and investigative procedures -- section 6. Revisional surgery.
- 2006 SpringerGiovanni Mantovani (ed.) ; co-editors, Stefan D. Anker ... [et al.].
- Calcineurin regulates the yeast synaptojanin Inp53/Sjl3 to promote membrane recovery during hyperosmotic stress2013Evan Lloyd Guiney.In response to hyperosmotic shock, cells of the budding yeast Saccharomyces cerevisiae lose up to 50% of their volume. This drastic decrease in cell size results in excess plasma membrane, which forms large infoldings that must be quickly removed. How these plasma membrane invaginations are resolved to restore the cell surface is not well understood. We show that hyperosmotic shock activates calcineurin, the Ca2+/calmodulin-dependent protein phosphatase, leading to restoration of normal membrane morphology. During hyperosmotic stress, actin patches (sites of endocytosis) become depolarized; we find that under these conditions calcineurin accumulates at sites of polarized growth and promotes actin patch repolarization. Hyperosmotic stress causes calcineurin to bind to the yeast synaptojanin Inp53/Sjl3 and dephosphorylate its proline rich tail. Dephosphorylation by calcineurin activates Inp53, which in turn dephosphorylates PI(4,5)P2 at the plasma membrane and promotes repolarization of the actin cytoskeleton. Consistently, cells lacking the partially redundant synaptojanins Inp51/Sjl1 and Inp52/Sjl2 require calcineurin for growth even in the absence of hyperosmotic stress, and display abnormal plasma membrane morphology when calcineurin activation of Inp53 is blocked. Finally, we find that calcineurin binding to Inp53 stimulates its association with the yeast amphiphysin Rvs167, suggesting model where calcineurin stimulates Inp53 and Rvs167 mediated membrane scission, promoting recovery from excess membrane stress and allowing resumption of polarized growth. In neurons, periods of intense synaptic vesicle release also result in excess membrane, and calcineurin stimulates association of synaptojanin with amphiphysin to promote synaptic vesicle endocytosis. Our findings in yeast suggest that stimulation of endocytic complex formation by Ca2+/calcineurin is a fundamental and conserved feature of the eukaryotic response to excess plasma membrane.
- 2006 Springeredited by Chen Hsing Hsu.
- 2007 Springeredited by Ernesto Carafoli and Marisa Brini.Annexinopathies / M.J. Hayes ... [et al.] -- Calpains and human disease / I. Bertipaglia and E. Carafoli -- Gelsolin and diseases / L. Spinardi and W. Witke -- Guanylate cyclase-activating proteins and retina disease / W. Baehr and K. Palczewski -- Pathologies involving the S100 proteins and rage / C.W. Heizmann ... [et al.] -- The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics / E.M. Brown -- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease / J. Colomer and A.R. Means -- Calcium channelopathies: Voltage-gated calcium channels / P.J. Adams and T.P. Snutch -- TRP channels in disease / S.E. Jordt and B.E. Ehrlich -- Diseases associated with altered ryanodine receptor activity / W.J. Durham ... [et al.] -- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease / I. Bezprozvanny -- SERCA pumps and human diseases / A. Hovnanian -- The plasma membrane calcium ATPase and disease / B.L. Tempel and D.J. Shilling -- Diseases involving the Golgi calcium pump / J. Vanoevelen ... [et al.] -- Calcium signalling and cancer cell growth / T. Capiod ... [et al.] -- Calcium misregulation and the pathogenesis of muscular dystrophy / F.W. Hopf ... [et al.] -- Calcium and cell death / A. Verkhratsky -- Calcium and cell death: The mitochondrial connection / P. Bernardi and A. Rasola -- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models / K.N. Green ... [et al.] -- Calcium and cardiomyopathies / E.G. Kranias and D.M. Bers -- Calcium signalling and calcium transport in bone disease / H.C. Blair ... [et al.].
- 2014 SpringerGary D Lopaschuk and Naranjan S. Shalla, editors.Part I. Control of Energy Metabolism -- A Primer on Carbohydrate Metabolism in the Heart / Heinrich Taegtmeyer -- Lipoproteins: A Source of Cardiac Lipids / Konstantinos Drosatos and Ira J. Goldberg -- Role of Lipoprotein Lipase in Fatty Acid Delivery to the Heart / Andrea Wan and Brian Rodrigues -- Control of Myocardial Fatty Acid Uptake / Jan F. C. Glatz and Joost J. F. P. Luiken -- Cardiac Energy Metabolism in Heart Failure Associated with Obesity and Diabetes / Gary D. Lopaschuk -- Transcriptional Control of Mitochondrial Biogenesis and Maturation / Rick B. Vega , Teresa C. Leone , and Daniel P. Kelly -- Relationship Between Substrate Metabolism and Cardiac Efficiency / Ellen Aasum -- Acetylation in the Control of Mitochondrial Metabolism and Integrity / Michael N. Sack -- Part II. Alteration in Energy Metabolism -- Adrenergic Control of Cardiac Fatty Acid Oxidation in Diabetes / Vijay Sharma and John H. McNeill -- The Myocardial Creatine Kinase System in the Normal, Ischaemic and Failing Heart / Craig A. Lygate and Stefan Neubauer -- Fuel Metabolism Plasticity in Pathological Cardiac Hypertrophy and Failure / Stephen C. Kolwicz and Rong Tian -- Defects in Mitochondrial Oxidative Phosphorylation in Hearts Subjected to Ischemia-Reperfusion Injury / Vijayan Elimban , Paramjit S. Tappia , and Naranjan S. Dhalla -- The Role of AMPK in the Control of Cardiac Hypertrophy / Nikole J. Byrne, Miranda M. Sung, and Jason R. B. Dyck -- The Role of Incomplete Fatty Acid β-Oxidation in the Development of Cardiac Insulin Resistance / John R. Ussher -- Part III. Optimization of Energy Metabolism -- Metabolic Therapy for the Ischemic Heart / Giacinta Guarini , Alda Huqi , and Mario Marzilli -- Inhibition of Fatty Acid Oxidation to Treat Heart Failure in Patients / Rui Yan , Jin Wei , and Dengfeng Gao -- Cardiac Metabolic Protection for the Newborn Heart / J. Carter Ralphe and Thomas D. Scholz -- Targeting Transcriptional Control of Fatty Acid Oxidation to Treat Heart Disease / Michael A. Portman and Aaron K. Olson.
- 2014 Kargervolume editors, Riccarda Granata, Jørgen Isgaard.Testosterone and cardiovascular risk in men / Kelly, D.M., Jones, T.H. -- Hormone therapy and venous thromboembolism among postmenopausal women / Scarabin, P.-Y. -- Cardiovascular and metabolic impact of glucocorticoid replacement therapy / Johannsson, G., Ragnarsson, O. -- Cardiovascular disease and thyroid function / Faber, J., Selmer, C. -- Hormonal alterations in heart failure : anabolic impairment in chronic heart failure -- diagnostic, prognostic and therapeutic issues / Arcopinto, M., Cittadini, A. -- Genetics of primary aldosteronism / Funder, J.W. -- Adipose tissue dysfunction and inflammation in cardiovascular disease / Wronkowitz, N., Romacho, T., Sell, H., Eckel, J. -- Potential peptides in atherosclerosis therapy / Marleau, S., Mellal, K., Huynh, D.N., Ong, H. -- Interaction between insulin-like growth factor-1 and atherosclerosis and vascular aging / Higashi, Y., Quevedo, H.C., Tiwari, S., Sukhanov, S., Shai, S.-Y., Anwar, A., Delafontaine, P. -- Ghrelin and the cardiovascular system / Tokudome, T., Kishimoto, I., Miyazato, M., Kangawa, K. -- Natriuretic peptide system and the heart / del Ry, S., Cabiati, M., Clerico, A. -- Beyond glycemic control : cardiovascular effects of incretin-based therapies / Angeli, F.S., Shannon, R.P.
- 2010 CRCnetBASELynne Berdanier, Carolyn D. Berdanier."Today's knowledge of human health demands a multidisciplinary understanding of medically related sciences, and Case Studies in the Physiology of Nutrition answers the call. Dedicated to the integration of nutrition science with physiology, this text cohesively incorporates descriptions of human problems in order to stimulate students' critical thinking about how the body integrates various physiological factors to maintain homeostasis. This textbook uses short story-type case studies about fictional individuals who have health problems in order to address a range of issues in an approachable manner. The studies vary in difficulty, with some being straightforward with very simple answers, while others require in-depth thinking and literature research to solve. Each study presents patient background, symptoms, clinical finding, and questions to ponder. Upon qualifying course adoption, this book also includes a valuable instructor's manual, which provides solutions to exercises, problem analysis, and resolution to each case study."--Publisher's description.
- Catalytic promiscuity in the alkaline phosphatase superfamily : identifying specificity determinants in the diesterase family leads to a hypothesis of a "generalist" core bimetallo site found throughout the superfamily2013Helen Irene Wiersma-Koch.Catalytic promiscuity, the property of enzymes possessing low levels of activity toward non-cognate reactions, can be exploited as a functional tool to investigate conserved and non-conserved mechanism of enzyme specificity and catalysis between members in the same superfamily. Members of the main branch of the Alkaline Phosphatase (AP) superfamily have a structurally conserved core and active site bimetallo site. Other active site features that confer specificity for a given reaction differ between the families. Families within this superfamily catalyze a wide range of reactions, and enzymes within different families show catalytic promiscuity toward reactions catalyzed by other families within this branch. Structural comparisons and phylogenetic analysis suggests that all of the families in the superfamily arose from a common ancestor whose active site consisted of the bimetallo site alone, absent of peripheral, specificity determining features. Experimental data with a member of the nucleotide pyrophosphatase/phosphodiesterase (NPP) family suggests that a "minimal" mutant version of this enzyme that lacks peripheral, specificity determining features, has equal activity toward the two major reactions catalyzed by the AP superfamily, phosphate monoester and phosphate diester hydrolysis reactions. Together, the structural comparisons, phylogenic analysis, and experimental results lead to the hypothesis that the common ancestor of the AP superfamily is a "generalist." By using a variety of techniques, we provide support for a mechanism of evolution in which a "generalist" enzyme may give rise to multiple enzymes specific for, related, but individual reactions. Support for this mechanism, first proposed in 1976, has, until, now been limited. We suggest that this "generalist" mechanism is a valid mechanism for the evolution of ancient enzymes, present in the early evolution of life, into diverse superfamilies in which each family possesses specificity for one given reaction.
- 2012Weizhe Hong.Neurons are interconnected with extraordinary precision to allow proper propagation and integration of neural activities. The organization of these specific connections emerges from sequential developmental events, including axon guidance, target selection, and synapse formation. Compared to axon guidance, little is known about how selection and matching between pre- and post-synaptic partners are achieved. To ensure the proper relay of olfactory information in flies, axons of ~50 classes of olfactory receptor neurons (ORNs) form one-to-one connections with dendrites of ~50 classes of projection neurons (PNs). Previous developmental analysis has shown that PN dendrites first target to specific areas within the developing antennal lobe to create a proto-map. This is followed by ORN axon invasion into the antennal lobe. However, it is unclear (1) how PNs target their dendrites to specific areas and (2) how ORN axons subsequently recognize PN dendrites to form highly specific one-to-one connections. To address the first question, I conducted a genetic screen to identify new genes involved in PN dendrite targeting. I identified Capricious, a leucine-rich repeat transmembrane protein that is differentially expressed in different PN classes. Loss- and gain-of-function studies indicate that Capricious instructs the segregation of Capricious-positive and negative PN dendrites to discrete glomerular targets. Moreover, the function of Capricious in regulating PN dendrite targeting is independent of pre-synaptic ORNs. The closely related protein Tartan plays a partially redundant function with Capricious. Therefore, these leucine-rich repeat proteins instruct targeting of PN dendrites to discrete glomeruli in the antennal lobe. To address the second question, we designed highly sensitive and robust assays to examine the matching and mismatching between PNs and ORNs. This allowed me to perform two unbiased screens, which independently identified two Teneurins, Ten-m and Ten-a, as synaptic matching molecules. Teneurins are EGF repeat-containing transmembrane proteins that are evolutionarily conserved from worms to mammals. Drosophila Teneurins, Ten-m and Ten-a, are highly expressed in select PN and ORN matching pairs. Loss- and gain-of-function of Teneurins cause specific mismatching of ORN axons and PN dendrites. Moreover, Teneurins promote homophilic interactions in vitro, and homophilically mediate trans-cellular interactions to promote PN-ORN attraction in vivo. Therefore, I propose that Teneurins instruct synaptic matching specificity between PNs and ORNs through homophilic attraction. The identification of Teneurins reveals a general mechanism for determining synapse specificity directly between pre- and post-synaptic neurons. In summary, I have identified two major mechanisms for the stepwise assembly of the olfactory circuit. In the first step, PN dendrites target to specific, discrete glomerular locations in the antennal lobe through a pair of leucine-rich repeat transmembrane proteins, Capricious and Tartan. Subsequently, ORN axons arrive at the antennal lobe, and recognize PN dendrites through homophilic attractions mediated by a pair of EGF repeat-containing transmembrane proteins, Ten-m and Ten-a. These molecules and underlying mechanisms not only help mechanistically understand the olfactory circuit assembly but also elucidate the general principles by which wiring specificity is established.
- 2012 Springer[edited by] Livio Luzi.1. Human Evolution and Physical Exercise: The Concept of Being "Born to Run" / Livio Luzi -- 2. Cell Morphology and Function: The Specificities of Muscle Cells / Anna Maestroni -- 3. The Cell Membrane of the Contractile Unit / Gianpaolo Zerbini -- 4. Gene Polymorphisms and Athletic Performance / Ileana Terruzzi -- 5. Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise / Stefano Benedini -- 6. Mitochondrial and Non-mitochondrial Studies of ATP Synthesis / Roberto Codella -- 7. Excessive Nutrients and Regional Energy Metabolism / Gianluca Perseghin -- 8. Muscle Biopsy To Investigate Mitochondrial Turnover / Rocco Barazzoni -- 9. Introduction to the Tracer-Based Study of Metabolism In Vivo / Andrea Caumo and Livio Luzi -- 10. Physical Activity and Inflammation / Raffaele Di Fenza and Paolo Fiorina -- 11. The HPA Axis and the Regulation of Energy Balance / Francesca Frigerio -- 12. Physical Exercise in Obesity and Anorexia Nervosa / Alberto Battezzati and Simona Bertoli -- 13. Physical Exercise and Transplantation / Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi -- 14. The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise / Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.
- Centrosomes, cilia and centriolar satellites : characterizing the role of Cep72 in centriolar satellite function2011Timothy Richard Stowe.Centrosomes and cilia are evolutionarily conserved organelles with important functions in cell signaling, organismal development and disease. Defects in centrosome and cilium function are associated with a set of phenotypically-related syndromes called ciliopathies. To discover new centrosome/cilium components, candidate genes were identified by virtue of their transcriptional upregulation in multiciliated tracheal epithelial cells and selected for further study based on their subcellular localization. Using this approach, Cep72 was identified as a component of centriolar satellites - poorly understood centrosome-associated structures defined by the protein PCM1. A subset of ciliopathy-associated proteins that includes BBS4, Cep290 and OFD1 associate with centriolar satellites, yet how this association affects their function is unknown. Cep72 was determined to be a PCM1-interacting protein and its association with centriolar satellites was characterized in detail. Cep72 was found to interact with Cep290 and overexpression/depletion experiments demonstrated that Cep72 facilitates recruitment of Cep290, but not BBS4, to centriolar satellites. Loss of satellites by depletion of PCM1 resulted in cytoplasmic disperal of BBS4 and redistribution of Cep72 and Cep290 from centriolar satellites to the centrosome. In contrast to the reported function of centriolar satellites in facilitating the localization of proteins to the centrosome, the effects of PCM1 depletion on Cep72 and Cep290 localization suggest that association with centriolar satellites can also restrict centrosomal localization for some proteins. During ciliogenesis, BBS4 transitions from centriolar satellites to the primary cilium, however regulation of this transition is not understood. Depletion of Cep72 or Cep290 prevented transition of BBS4 localization, causing BBS4 to remain localized to centriolar satellites in ciliated cells. Depletion of PCM1 or Cep72 in developing zebrafish embryos resulted in phenotypes consistent with centrosome/cilium defects, suggesting centriolar satellites influence cilium function during development. Given these results, we propose that centriolar satellites function in modulating the ciliary localization of BBS4 and possibly other ciliogenesis factors, via a mechanism that involves Cep290 as an effector of that regulation. The distribution of centriolar satellites around the centrosome during interphase requires microtubules and dynein. During the cellular stress response to misfolded proteins, protein aggregates are transported in a microtubule and dynein-dependent manner to structures surrounding the centrosome referred to as aggresomes. We observed PCM1-dependent recruitment of centriolar satellite proteins to aggresomes, which prompted further investigation of the potential involvement of PCM1 in aggresome formation. Depletion of PCM1 had modest effects on aggresome formation and cell viability in response to misfolded proteins. However the influence of PCM1 on centrosome function and microtubule organization could not be ruled out as possible explanation for these effects.
- v. 1-2, 1954-.Greenberg, David M.
- 2014 CRCnetBASEedited by Rexford S. Ahima, MD, PhD.Part I. Genetic and environmental factors -- part II. Adverse health consequences -- part III. Prevention and treatment.
- 2012 Wileyedited by Irena Levitan, Francisco Barrantes.Cholesterol trafficking and distribution between cellular membranes / Daniel Wustner, Lukasz M. Solanko, Frederik W. Lund -- Cholesterol regulation of membrane protein function by changes in bilayer physical properties : an energetic perspective / Jens A. Lundbaek and Olaf S. Andersen -- Insights into structural determinants of cholesterol sensitivity of Kir channels / Avia Rosenhouse-Dantsker and Irena Levitan -- Role for lipid rafts in the regulation of store-operated Ca2+ channels / Hwei L. Ong and Indu S. Ambudkar -- Cholesterol regulation of cardiac ion channels / Elise Balse, Stephane Hatem and Stanley Nattel -- Differential contribution of BK subunits to nongenomic regulation of channel function by steroids / Alex M. Dopico, Anna N. Bukiya, and Aditya K. Singh -- Regulation of K+ channels by cholesterol-rich membrane domains in immune system / Núria Comes and Antonio Felipe -- Indirect channel regulation by cholesterol : the role of caveolae and caveolins in regulating KATP channel function / Caroline Dart -- Regulation of the nicotinic acetylcholine receptor by cholesterol as a boundary lipid / Francisco J. Barrantes -- Specific and non-specific regulation of GPCR function by cholesterol / Gerald Gimpl and Katja Gehrig-Burger -- Structural insights into cholesterol interactions with G protein-coupled receptors / Jeremiah S. Joseph, Enrique E. Abola, and Vadim Cherezov -- Membrane cholesterol : implications in receptor function / Sandeep Shrivastava and Amitabha Chattopadhyay -- The role of cholesterol and lipid rafts in regulation of TLR receptors / Ruxana T. Sadikot.
- Clinical aspects and laboratory : iron metabolism, anemias : concepts in the anemias of malignancies and renal and rheumatoid diseases. 6th, rev. and updated ed.2011 SpringerManfred Wick, Wulf Pinggera, Paul Lehmann ; with contributions by Volker Ehrhardt.
- 2006Martin A. Crook.
- 2007 OvidSandra Gibson Hassink.Introduction: medical management of obesity -- Epidemiology of childhood obesity -- Pathophysiology of obesity -- Obesity in the context of child and adolescent development -- Evaluation of the obese child -- Respiratory complications -- Cardiovascular complications -- Insulin resistance, the metabolic syndrome, and type 2 diabetes -- Orthopedic complications -- Gastrointestinal complications -- Renal complications -- Neurologic complications -- Mental health issues -- Specific genetic causes of obesity -- Acute obesity-related emergencies -- Practice management strategies for obesity.
- Clinical management of overweight and obesity : recommendations of the Italian Society of Obesity (SIO)2016 SpringerPaolo Sbraccia, Enzo Nisoli, Roberto Vettor, editors.Part I: General remarks -- Overview of the Management of the Obese Patient -- Part II: Lifestyle modifications -- Diet -- Physical Activity -- Therapeutic education -- Part III: Treatment -- Pharmacological Management -- Bariatric surgery -- Metabolic-Nutritional-Psychological Rehabilitation in Obesity -- Part IV: Obesity in Particular Conditions and Treatment Algorithm -- Eating Disorders and Obesity -- Obesity in Pregnancy -- Childhood Obesity -- Geriatric Obesity -- Multidimensional Evaluation of the Obese patient and Level of Care -- Treatment Algorithm of Patients with Overweight and Obesity. .
- 2014 CRCnetBASEedited by Leah Coles, PhD.The field of clinical nutrition as a whole seeks to consider the nutrition of patients within the healthcare system, paying attention to the interactions between diet, nutrition, and disease. To that end, this book discusses nutrition as both a contributing and managing factor in relation to diseases such as obesity and diabetes. It also presents malnutrition as a contributing factor to such diseases and considers the efficacy of micronutrient supplementation. It ends by looking at some of the recent developments and future trends in the field of clinical nutrition.
- 2007 Springeredited by Derek Pearson and Colin G. Miller.
- 2015 SpringerAdrienne Youdim.1. The disease of obesity -- 2. The health burden of obesity -- 3. Psychosocial morbidity and the effect of weight loss -- 4. Dietary and lifestyle strategies for weight loss -- 5. Physical activity and writing an exercise prescription -- 6. The doctor's tool kit: pharmacolotherapy for the patient with obesity -- 7. Roux-en-Y gastric bypass: procedure and outcomes --- 8. Sleeve gastrectomy: procedure and outcomes -- 9. Laparoscopic adjustable gastric banding: procedure and outcomes -- 10. Perioperative care of the surgical patient -- 11. Surgical complications of weight loss surgery -- Index.
- 2012 SpringerMarshall D. McCue, editor.An introduction to fasting, starvation, and food limitation / Marshall D. McCue -- A history of modern research into fasting, starvation, and inanition / Jean-Hervé Lignot and Yvon LeMaho -- Starvation in rotifers : physiology in an ecological context / Kevin L. Kirk -- Drosophila as a model for starvation : evolution, physiology, and genetics / Alen G. Gibbs and Lauren A. Reynolds -- Metabolic transitions during feast and famine in spiders / Johannes Overgaard and Tobias Wang -- Adaptation of the physiological, endocrine, and digestive system functions to prolonged food deprivation in fish / Nadav Bar and Helene Volkoff -- Starvation in subterranean species versus surface-dwelling species : crustaceans, fish, and salamanders / Frédéric Hervant -- Physiological responses to starvation in snakes : low energy specialists / Marshall D. McCue, Harvey B. Lillywhite, and Steven J. Beaupre -- Cardiovascular circuits and digestive function of intermittent-feeding sauropsids / Rike Campen and Matthias Starck -- Thermoregulatory adaptations to starvation in birds / Esa Hohtola -- Fasting in birds : general patterns and the special case of endurance flight / Susanne Jenni-Eiermann and Lukas Jenni -- Tissue-specific mass changes during fasting : the protein turnover hypothesis / Ulf Bauchinger and Scott R. McWilliams -- Seasonal changes in body mass and energy balance in wild small mammals / Xueying Zhang, Xinyu Liu, and Dehua Wang -- Changes in form and function of the gastrointestinal tract during starvation : from pythons to rats / Jehan-Hervé Lignot -- Changes in fatty acid composition during starvation in vertebrates : mechanisms and questions / Edwin R. Price and Teresa G. Valencak -- Physiological responses to fasting in bats / Miriam Ben-Hamo, Agustí Muñoz-Garcia, and Berry Pinshow -- Muscle protein and strength retention by bears during winter fasting and starvation / Hank Harlow -- Seasonal starvation in northern white-tailed deer / Duane E. Ullrey -- Fasting physiology of the pinnipeds : the challenges of fasting while maintaining high energy expenditure and nutrient delivery for lactation / Cory D. Champagne ... [et al.] -- The use and application of stable isotope analysis to the study of starvation, fasting, and nutritional stress in animals / Kent A. Hatch -- Fearing the danger point : the study and treatment of human starvation in the United Kingdom and India, c. 1880-1974 / Kevin Grant -- Quantitative physiology of human starvation : adaptations of energy expenditure, macronutrient metabolism, and body composition / Kevin D. Hall -- Alternate day fasting : effects on body weight and chronic disease risk in humans and animals / Krista A. Varady -- Horizons in starvation research/ Marshall D. McCue.
- 2014 Springeredited by David Haslam, Arya Sharma, Carel Le Roux.Obesity is a relatively new and controversial field of medicine. Some of the controversies surrounding obesity can be dismissed as myths, others reveal the lack of consensus and comprehensive knowledge which exist in obesity and its complex relationship with diabetes and other serious long-term conditions. Controversies in Obesity takes the unique approach of assessing the controversies surrounding obesity, thus seeking to debunk the myths and highlight and explore the genuine science, whilst demonstrating areas where there is healthy debate. This book will appeal to primary care physicians, trainees and specialist nurses involved in care of the obese patient, and would be of interest to anyone who wishes to gain a better understanding of the complex nature of obesity and its management.
- 2012 Wileyedited by Ali A. El SolhCardiovascular physiology in obesity / Martin A. Alpert and Eric J. Chan -- Effects of obesity on respiratory physiology / Philippe Abou Jaoude, Jahan Porhomayon, Ali El Solh -- Gastrointestinal physiology in obesity / Alexander D. Miras and Carel W. le Roux -- Metabolic and endocrine physiology in obesity / Paula Alvarez-Castro, Susana Sangiao-Alvarellos, and Fernando Cordido -- Sedation, paralysis, and pain management of the critically ill obese patient / Christopher G. Hughes, Lisa Weavind, and Pratik Pandharipande -- Renal physiology in the critically ill obese patient / Eric A.J. Hoste and Jan J. De Waele -- Upper airway management in the morbidly obese patient / Michael Tielborg and Anthony Passannante -- Mechanical ventilation of the obese patient / Mohammed Mogri and M. Jeffery Mador -- Management of acute lung injury in the obese patient / Hallie C. Prescott and James M. O'Brien Jr. -- Management of infectious complications in the critically ill obese patient / Kristin Turza Campbell [and others] -- Management of gastrointestinal complications of the critically ill obese patient / Benjamin H. Levy III and David A. Johnson -- Management of metabolic and endocrine complications of the critically ill obese patient / Joseph Varon and Ilse M. Espina -- Management of venous thromboembolism in the critically ill obese patient / Terence K. Trow, Richard Matthay -- Hemodynamic monitoring of the critically ill obese patient / Wim K. Lagrand, Eline R. van Slobbe-Bijlsma, Marcus J. Schultz -- Diagnostic imaging of the critically ill obese patient / Venkata S. Katabathina [and others] -- Post operative care of the obese patient / Hui Sen Chong and Robert L. Bell -- Management of the obese patient with trauma / Hadley K. Herbert and Therèse M. Duane -- Abdominal solid organ transplantation in the obese patient / Erin C. Hall and Dorry L. Segev -- Critical care management of the obese patient after bariatric surgery / Scott E. Mimms and Samer G. Mattar -- Drug dosing in the critically ill patient / Brian L. Erstad -- Nutritional requirements of the critically ill obese patient / Bikram S. Bal, Frederick C. Finelli, and Timothy R. Koch -- Nursing care of the critically ill obese patient / Margaret E. McAtee -- Prognosis and outcome of critically ill obese patient / Yasser Sakr, Mohamed Zeiden, and Juliana Marques -- Ethical considerations in the critically ill obese patient / Mark D. Siegel.
- 2013Lisa Michelle McGinnis.Vascular endothelial growth factor (VEGF) signaling plays key roles in vascular development and is a therapeutic target in the treatment of malignancies. By blocking VEGF from binding to the VEGF receptor in mice pharmacologically, we show that VEGF inhibition is associated with a decrease in serum glucose levels and a suppression of hepatic glucose production. In adult wild-type mice, chronic VEGF inhibition results in lower fasting and post-prandial glucose levels and enhanced glucose tolerance. Using a hyperinsulinemic euglycemic clamp study, we find that VEGF inhibition leads to suppression of hepatic glucose production via sensitization of hepatic insulin signaling. Furthermore, gene expression analysis of livers from VEGF-inhibitor treated mice shows decreased expression of the glucose-6-phosphatase catalytic subunit (G6pc) and phosphoenolpyruvate carboxykinase (Pepck), both enzymes involved in hepatic gluconeogenesis. We also observe an up-regulation of canonical HIF-2[alpha] target genes in livers from VEGF inhibited mice, and find that HIF-2[alpha] is required for VEGF-inhibitor mediated suppression of hepatic glucose production as mice genetically lacking hepatic Hif2[alpha] (Hif2[alpha]flox/flox Albumin Cre recombinase) do not have the enhanced glucose tolerance and hypoglycemia observed in wild-type mice. Furthermore, mice treated with an adenovirus expressing a constitutively active Hif-2[alpha] allele (Ad-Hif2[alpha]PN) results in a phenocopy of VEGF inhibitor treated mice, indicating that activation of HIF-2[alpha] mediated signaling is not only necessary but also sufficient for suppression of hepatic gluconeogenesis. Western blot analysis of liver extracts from VEGF inhibitor treated mice show increased levels of two key downstream mediators of insulin receptor signaling, insulin receptor substrate 2 (IRS-2) and phosphorylated-Akt (p-Akt) when compared with controls. In fact, Ad-Hif2[alpha]PN requires Irs-2 expression to sensitize insulin signaling in primary hepatocytes, since shRNA mediated depletion of IRS-2 reduces the expected phosphorylation of Akt in response to exogenous insulin stimulation. Furthermore, we show that Hif2[alpha]PN suppresses expression of Srepb-1c, a negative regulator of Irs-2, thereby increasing expression of Irs-2. To address whether modulation of HIF-2[alpha] activity by VEGF-inhibitors may be a potential therapeutic target in diabetes, we treated diabetic, insulin resistant db/db mice with VEGF inhibitors and find significant improvement in glucose tolerance, decreases in fasting as well as post-prandial glucose levels and correction of hyperinsulinemia in a Hif-2[alpha]-dependent manner. In summary, we present evidence of crosstalk between hypoxia and insulin signaling pathways via HIF-2[alpha] modulation and that stimulation of hepatic HIF-2[alpha] may be a therapeutic target for treating type II diabetes. A second focus of this thesis examines the role of HIF-2[alpha] in mediating the ability of VEGF inhibitors to increase hematocrit. We show that VEGF inhibitors increase hematocrit in both hepatic Hif-2[alpha]-independent and --dependent ways. VEGF inhibitors require hepatic Hif-2[alpha] to induce hepatic erythropoietin (EPO)-dependent erythrocytosis and polycythemia. Conditional inactivation of hepatic Hif-2[alpha] suppresses the ability of VEGF inhibitors to increase hepatic Epo expression, reticulocytosis and hematocrit. VEGF inhibitors also increase hematocrit through a contraction in blood plasma volume in an EPO- and Hif-2[alpha]-independent manner. This thesis demonstrates that hepatic HIF-2[alpha] has essential roles both in modulating carbohydrate metabolism and inducing expression of Epo. These activities can be manipulated by treatment with VEGF inhibitors.
- 2006 SpringerUwe Lendeckel, Dirk Reinhold, Ute Bank, editors.Topic I. Structure and function. Peptide substrates of dipeptidyl peptidases / Inger Brandt ... [et al.] Phosphorus-containing inhibitors of proteolytic enzymes / Angel Stöckel-Maschek ... [et al.] Biochemical properties of recombinant prolyl dipeptidases DPP-IV and DPP8 / Xin Chen. Prediction of dipeptidyl peptidase (DP) 8 structure by homology modelling / Melissa R. Pitman, R. Ian Menz, and Catherine A. Abbott -- Topic II. DPIV-related enzymes. Structure and function in dipeptidyl peptidase IV and related proteins / Mark D. Gorrell ... [et al.] Expression and function of dipeptidyl peptidase IV and related enzymes in cancer / Petr Busek ... [et al.] DP8 and DP9 have extra-enzymatic roles in cell adhesion, migration, and apoptosis / Denise M.T. Yu ... [et al.] In vivo effects of a potent, selective DPPII inhibitor: UAMC00039 is a possible tool for the elucidation of the physiological function of DPPII / Marie-Berthe Maes ... [et al.] Expression of dipeptidyl peptidase IV-like enzymes in human peripheral blood mononuclear cells / Sabine Wrenger ... [et al.] Dipeptidyl peptidase 8 has post-proline dipeptidyl aminopeptidase and prolyl endopeptidase activities / Joohong Park ... [et al.] Prolyl endopeptidase cleaves the apoptosis rescue peptide humanin and exhibits and unknown post-cysteine cleavage specificity / Joachim Wolfgang Bär ... [et al.] Distribution of dipeptidyl peptidase IV-like activity enzymes in canine and porcine tissue sections by RT-PCR / Leona Wagner ... [et al.] -- Topic III. Metabolic disorders. Relative contribution of incretins to the glucose lowering effect of DP IV inhibitors in type 2 diabetes mellitus (T2DM) / Simon A. Hinke, Raymond A. Pederson, and Christopher H.S. McIntosh. Dipeptidyl peptidase IV: a molecular switch of vascular actions of neuropeptide Y / Lijun Li, Hans-Ulrich Demuth, and Zofia Zukowska -- Topic IV. Immune disorders. Dipeptidylpeptidase IV (DPIV) and alanyl-aminopeptidases (AAPs) as a new target complex for treatment of autoimmune and inflammatory diseases: proof of concept in a mouse model of colitis / Ute Bank ... [et al.] Dipeptidyl peptidases and inflammatory bowel disease / Catherine A. Abbott ... [et al.] Possible role of DP IV inhibitors in acne therapy / Anja Thielitz ... [et al.] Dipeptidyl peptidase-IV activity and/or structure homologs (DASH): contributing factors in the pathogenesis of rheumatic diseases? / Eva Balaziova ... [et al.] -- Topic V. Neuronal diseases. Dipeptidyl peptidase IV (DP IV, CD26) and aminopeptidase N (APN, CD13) as regulators of T cell function and targets of immunotherapy in CNS inflammation / Aliza Biton ... [et al.] CD26/DP IV in T cell activation and autoimmunity / Vera Preller ... [et al.] DPIV/CD26 and FAP in cancer: a tale of contradictions / Melanie L. Sulda, Catherine A. Abbott, and Martin Hildebrandt. Type-II transmembrane prolyl dipeptidases and matrix metalloproteinases in membrane vesicles of active endothelial cells / Monica Salamone ... [et al.] Extra-enzymatic roles of DPIV and FAP in cell adhesion and migration on collagen and fibronectin / Xin M. Wang ... [et al.] Role of neuropeptide Y and dipeptidyl peptidase IV in regulation of Ewing's sarcoma growth / Joanna Kitlinska ... [et al.] The role of CD26/DPP IV in preservation of early pulmonary graft function / Florian Johannes Jung ... [et al.].Also available: Print – 2006
- 2013 SpringerPaolo Capodaglio, Joel Faintuch, Antonio Liuzzi, editors."Obesity is currently regarded as one of the major health challenges of the developed world. Excess body weight is an important risk factor for morbidity and mortality from cardiovascular diseases, diabetes, cancer, musculoskeletal disorders and even psychiatric problems and is estimated to cause nearly 3 million deaths per year worldwide. Obesity is not necessarily associated with comorbidities: there are indeed metabolically healthy obese individuals. Thus, we need to consider individuals presenting simple with obesity separately from those at risk of developing or who have already developed complex clinical states potentially leading to disability. Comorbidities can tip the balance of independence in patients who already have functional limitations mainly due to the excess of mass itself or who develop conditions such as diabetes, cardiovascular conditions, non-alcoholic fatty liver disease, where an abnormal metabolism of adipose tissue prevails. Morbid obesity with comorbidities leading to disability represents a real social and economic burden for National Health Systems worldwide. The presence of multiple and associated comorbidities often represents an obstacle to being admitted to hospitals for the treatment of metabolic diseases. On the other hand, clinical units with optimal standards for the treatment of pathological conditions in normal-weight patients are often structurally and technologically inadequate for the care of patients with extreme obesity. The aim of this book is to focus on the pathophysiological and rehabilitative aspects of disabling obesity, highlighting multidisciplinary rehabilitation interventions as key to counteracting the disabling aspects of complicated obesity"--Provided by publisher.
- 2012Kristen Jones Holmes.Whi3 is an RNA binding protein that regulates cell cycle entry by binding to mRNA of the G1 cyclin CLN3 and to the cyclin-dependent kinase Cdc28. Cln3 binds to Cdc28 to promote passage through Start. whi3[delta] cells have a small size phenotype, and Whi3 may regulate cell size by sequestering CLN3 mRNA and Cdc28 protein in the cytoplasm to delay G1 entry (Wang et al., 2004). We observe that Whi3 reversibly localizes from the cytosol to cytoplasmic puncta in response to glucose deprivation and heat shock. This phenotype is shared by components of stress granules (SGs), which are large RNP complexes that form in yeast in response to various stress conditions; SGs sort and process mRNAs during the stress response (Buchan et al., 2008). Because Whi3 shares several characteristics with known SG components, including an RNA binding domain and stress-dependent relocalization, we hypothesize that Whi3 is a novel component of SGs. We show that Whi3 colocalizes with SG markers in response to glucose deprivation and heat shock. Preventing SG formation inhibits Whi3 foci formation. Like SG components, Whi3 is enriched in insoluble cell fractions during stress. Whi3 is not required for SG formation, but may be targeted to SGs to carry out a previously unknown function. We conclude that Whi3 is a novel component of yeast stress granules. This observation suggests an alternative model for Whi3 function: that Whi3 might regulate mRNA translation during stress by transporting mRNA to stress granules. We demonstrate that Whi3 regulates many of its interacting RNAs, and that this regulation may promote stress-dependent survival.
- 2013Dustin Howard Hite.The central dogma of biology states that DNA, the genetic information, is transcribed into RNA, an information containing intermediate, which is then translated into proteins, actionable molecules which perform the majority of tasks required for life. To synthesize proteins, the cell employs a massive, macromolecular machine, the ribosome, and a myriad of protein factors to successfully translate an mRNA. My graduate studies have focused both on the ribosome and the protein translation factors that interact with the ribosome to facilitate translation initiation, elongation, and termination. First, utilizing recent advances in high throughput sequencing, we discovered that sequencing of ribosome protected fragments could illuminate in vivo dynamics of ribosome structural changes in Saccharomyces cerevisiae. We demonstrated that the ribosome protects two distinct sizes of fragments and assigned each fragment population to approximate stages of the translation elongation cycle where large structural rearrangements of the ribosome are known to occur. Once these assignments were made, we were able to model elongation speed and demonstrated that, contrary to previous reports, tRNA abundance and codon optimality were not the major determinants of elongation speed; surprisingly our data indicated that the polarity of the amino acid being decoded dictated elongation rates under these conditions, with polar amino acids acting to slow elongation rates. This study also implicated Dom34, a known NO GO decay factor, as a novel component of canonical translation termination and ribosome recycling. Second, we used another genome-wide assay of translation, "gradient encoding" microarray analysis, to interrogate the genome-wide effects of depleting five individual translation factors. Based on the current understanding of the molecular mechanisms of each translation factor, we hypothesized that the depletion of each factor would result in differential translation of mRNAs based on the physical properties of each mRNA species. However, we were startled to observe that the translational program of S. cerevisiae was relatively unperturbed by the depletion of three initiation factors, one elongation factor, and one termination factor. Further investigation revealed that yeast were actively compensating for the deficiency of each factor by either increasing or decreasing translation initiation rates such that the depleted factor was no longer limiting. This tuning was mediated by changes in eIF2[alpha] phosphorylation levels, a known modulator of translation initiation. Overall, we have leveraged high throughput technologies to provide novel understanding of in vivo structural dynamics of the ribosome and reveal a novel, unexpected robustness of the translational program in S. cerevisiae.
- Dissertation]. Part I, Unnatural thymidine analogs and shape mimics as substrates for human thymidine kinases. Part II, Fluorescent size-expanded DNA analogs as efficient substrates for a template-independent DNA polymerase2011Sarah King Jarchow-Choy.This thesis is composed of two separate studies involving unnatural nucleoside (DNA) analogs in two different types of enzymes: human thymidine kinases 1 and 2 and terminal deoxynucleotidyl transferase (TdT). The ability of two types of unnatural DNA analogs, nonpolar nucleoside analogs and expanded nucleoside analogs, to act as efficient substrates in enzymes will be described. Nonpolar nucleoside analogs lacking the ability to hydrogen bond were synthesized to systematically vary in size and shape, and then used to probe the ability of two types of human thymidine kinases (TK1 and TK2) to recognize and phosphorylate these analogs. The results establish that nucleoside recognition mechanisms for these two classes of thymidine kinase are very different. On the basis of this data, nonpolar nucleosides are likely to be active in the nucleotide salvage pathway in human cells, suggesting new designs for bioactive molecules. Another class of nucleoside analogs, expanded nucleoside (xDNA) analogs, maintain the ability to hydrogen-bond to their respective natural bases, but have enhanced pi-stacking due to their larger size, allowing the molecule to have greater stability in a DNA duplex, and unique fluorescent properties. It was found that terminal deoxynucleotidyl transferase (TdT), a template-independent DNA polymerase, can accept multiple xDNA nucleotide analogs as substrates with efficiencies close to that of natural nucleotides. In addition, the expanded adenine (xA) and cytosine (xC) analogs show a visible and spectral change in fluorescence when TdT incorporates multiple analogs. The ease of enzymatic synthesis of these analogs and their inherent fluorescence suggest their use in nucleic acid labeling and hybridization studies. The comparable efficiencies which nonpolar nucleoside analogs and xDNA nucleotide analogs have to natural bases in thymidine kinases and TdT give new information about the steric and electronic requirements of these enzymes, and will be useful for potential therapeutic and biotechnological applications.
- 2010 Springer[edited by] Esther Lubzens, Joan Cerdà, Melody Clark.Many organisms have evolved the ability to enter into and revive from a dormant state. They can survive for long periods in this state (often even months to years), yet can become responsive again within minutes or hours. This is often, but not necessarily, associated with desiccation. Preserving one 's body and reviving it in future generations is a dream of mankind. To date, however, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived at ambient temperatures. In this book studies on organisms, ranging from aquatic cyanobacteria that produce akinetes to hibernating mammals, are presented, and reveal common but also divergent physiological and molecular pathways for surviving in a dormant form or for tolerating harsh environments. Attempting to learn the functions associated with dormancy and how they are regulated is one of the great future challenges. Its relevance to the preservation of cells and tissues is one of the key concerns of this book
- 2012Heather Briana DeBruhl.The Myb gene family plays a role in several types of human cancers. For example, high expression levels of c-Myb in colon cancer and B-Myb in breast cancer correlated with poor prognosis for the patient. B-Myb, the vertebrate homolog of invertebrate Myb, activates transcription of mitotic genes. In Drosophila, mutation of Myb reduced expression of mitotic genes, such as the regulatory kinase genes polo and ial (AurB). Previous studies revealed multiple mitotic defects in Myb mutant cells, including disrupted chromosome condensation and abnormal spindles. I now show that binucleate cells, the hallmark phenotype of cytokinesis failure, accumulate in Myb-null ovarian follicle cell and wing disc epithelia. Myb functions as an activator in the generally repressive Drosophila RBF, E2F2, and Myb (dREAM)/Myb-MuvB complex. Absence of the dREAM subunits Mip130 or E2F2 suppressed the Myb-null cytokinesis defect. While previous Myb-null mitotic phenotypes were difficult to quantitatively assay, the binucleate phenotype was binary, countable, and had a near zero background level in wild-type tissues. This offered a unique opportunity to use the Myb-null binucleate phenotype to study how the dREAM complex represses transcription. In the absence of Myb, repression by the dREAM complex was sensitive to the decreased dose of the subunits E2F2, Mip120, Caf1, and interestingly Lin-52, which was previously genetically implicated as an activator in the complex. Surprisingly, reducing the dose of His2Av also suppressed the Myb-null binucleate phenotype, suggesting a novel role for this variant histone in transcriptional repression by the dREAM complex.
- 2006 ScienceDirectedited by Markus J. Seibel, Simon P. Robins, John P. Bilezikian.Structure, biosynthesis and gene regulation of collagens in cartilage and bone / Klaus von der Mark -- Fibrillogenesis and maturation of collagens / Simon P. Robins -- Vitamin K dependent proteins of bone and cartilage / Caren M. Gundberg and Satoru K. Nishimoto -- Noncollagenous proteins: glycoproteins and related proteins / Dick Heinegård, Pilar Lorenzo, and Tore Saxne -- Proteoglycans and glycosaminoglycans / Tim Hardingham -- Growth factors / Philippa Hulley, Graham Russell, and Peter Croucher -- Prostaglandins and proinflammatory cytokines / Lawrence G. Raisz and Joseph A. Lorenzo -- Integrins and other adhesion molecules / M.H. Helfrich and M.A. Horton -- Alkaline phosphatases / José Luis Millán -- Acid phosphatases / Helena Kaija ... [et al.] -- Matrix proteinases / Ian M. Clark and Gillian Murphy -- Mineralization, structure and function of bone / Adele L. Boskey -- Bone structure and strength / Ego Seeman -- The cells of bone / Jane B. Lian and Gary S. Stein -- Signaling in bone / T. John Martin and Natalie A. Sims -- Parathyroid hormone: structure, function and dynamic actions / Lorraine A. Fitzpatrick and John P. Bilezikian -- Interaction of parathyroid hormone-related peptide with the skeleton / David Goltzman -- The vitamin D hormone and its nuclear receptor: mechanisms involved in bone biology / Geert Carmeliet ... [et al.] -- Sex steroid effects on bone metabolism / David G. Monroe, Thomas C. Spelsberg, and S. Khosla -- Physiology of calcium and phosphate homeostasis / René Rizzoli and Jean-Philippe Bonjour -- The central control of bone remodelling / Paul A. Baldock ... [et al.] -- New concepts in bone remodeling / David W. Dempster and Hua Zhou -- Products of bone collagen metabolism / Juha Risteli and Leila Risteli -- Supramolecular structure of cartilage matrix / Peter Bruckner -- Products of cartilage metabolism / Daniel-Henri Manicourt, Jean-Pierre Devogelaer, and Eugene J.-M.A. Thonar -- Fluid dynamics of the joint space and trafficking of matrix products / Peter A. Simkin -- Transgenic models of bone disease / Barbara E. Kream and John R. Harrison -- The role of genetic variation in osteoporosis / André G. Uitterlinden ... [et al.] -- Measurement of calcium, phosphate and magnesium / Heinrich Schmidt-Gayk -- Measurement of parathyroid hormone / Harald Jüppner and Ghada El-Hajj Fuleihan -- New horizons for assessment of vitamin D status in man / Gary L. Lensmeyer, Neil Binkley, and Marc K. Drezner -- Measurement of biochemical markers of bone formation / Kim E. Naylor and Richard Eastell -- Measurement of biochemical markers of bone resorption / Marius E. Kraenzlin and Markus J. Seibel -- Variability in the measurement of biochemical markers of bone turnover / Tuan V. Nguyen, Christian Meier, and Markus J. Seibel -- Validation of biochemical markers of bone turnover / Kim Brixen and Erik Fink Eriksen -- Genetic markers of joint disease / Michel Neidhart, Renate E. Gay, and Steffen Gay -- Laboratory assessment of postmenopausal osteoporosis / Patrick Garnero and Pierre D. Delmas -- Monitoring anabolic treatment / John P. Bilezikian and Mishaela R. Rubin -- Monitoring of antiresorptive therapy / Christian Meier, Tuan V. Ngyen, and Markus J. Seibel -- Age-related osteoporosis and skeletal markers of bone turnover / Clifford J. Rosen -- Steroid-induced osteoporosis / Ian R. Reid -- Transplantation osteoporosis: biochemical correlates of pathogenesis and treatment / Carolina A. Moreira Kulak and Elizabeth Shane -- Secondary osteoporosis / Jean E. Mulder, Carolina A. Moreira Kulak, and Elizabeth Shane -- Osteomalacia and rickets / Marc K. Drezner -- Assessment of bone and joint diseases: renal osteodystrophy / Esther A. González, Ziyad Al Aly, and Kevin J. Martin -- Primary hyperparathyroidism / Shonni J. Silverberg, and John P. Bilezikian -- Paget's disease of bone / Andreas Grauer, Ethel Siris, and Stuart Ralston -- Metastatic bone disease / Jean-Jacques Body -- Rare bone diseases / Michael P. Whyte -- Osteogenesis imperfecta / Francis H. Glorieux and Frank Rauch -- Rheumatoid arthritis and other inflammatory joint pathologies / Steven R. Goldring and Mary B. Goldring -- Osteoarthritis and degenerative spine pathologies / Kristina Åkesson.
- 2015 SpringerAbhimanyu Garg.Dyslipidemias: Pathophysiology, Evaluation and Management provides a wealth of general and detailed guidelines for the clinical evaluation and management of lipid disorders in adults and children. Covering the full range of common through rare lipid disorders, this timely resource offers targeted, practical information for all clinicians who care for patients with dyslipidemias, including general internists, pediatric and adult endocrinologists, pediatricians, lipidologists, cardiologists, internists, and geneticists. For the last twenty years, there has been a growing recognition worldwide of the importance of managing dyslipidemia for the primary and secondary prevention of atherosclerotic vascular disease, especially coronary heart disease. This has been mainly due to the publication of the guidelines of National Cholesterol Education Programs Adult Treatment Panel and Pediatric Panel from the United States. These guidelines have stimulated generation of similar recommendations from all over the world, particularly Europe, Canada, Australia and Asia. Developed by a renowned group of leading international experts, the book offers state-of-the-art chapters that are peer-reviewed and represent a comprehensive assessment of the field. A major addition to the literature, Dyslipidemias: Pathophysiology, Evaluation and Management is a gold-standard level reference for all clinicians who are challenged to provide the best care and new opportunities for patients with dyslipidemias.
- 2009 Springeredited by Berthold Koletzko ... [et al.].Also available: Print – 2009
- 2008 HighWireedited by H. Bryan Brewer, Jean-Pierre Després.
- 2009 CRCnetBASERobert F. Dons and Frank H. Wians Jr.This volume updates its classic predecessor in both content and format. Written by two of the respected authorities in diagnostic endocrinology, it includes detailed information on how to perform and interpret those laboratory test procedures used to confirm the clinical diagnosis of the majority of known endocrine disorders. Newly designed, it provides a standardized format that makes it easier to access complete information about the diagnosis, screening, and management of traditional and newly perceived endocrine disorders. It provides sample calculations to assist with complex formulas as well as ICD-9 codes for all procedures.
- v. 1-, 2011- Springer
- 2012 SpringerSanford D. Markowitz, Nathan A. Berger, editors.The gastrointestinal track provides one of the distinct systems where multiple malignancies, including adenocarcinoma of the pancreas, esophagus and colon are each associated with obesity. This unique association is covered in this volume of Energy Balance and Cancer from the epidemiologic, biologic and potential etiologic viewpoint. The focus on possible dietary contribution as well as the role of exercise in prevention and therapy is presented in both animal model and patient based studies. Special focus is provided also on the role of genetic mutations and inflammatory pathways as drivers of these obesity related gastrointestinal malignancies. Overall, this volume on Energy Balance and Gastrointestinal Malignancies should be valuable to Epidemiologists, Gastroenterologists and Oncologists, as well as to students and researchers from multiple disciplines interested in understanding and disrupting the association between obesity and cancer.
- 2012 SpringerSteven D. Mittelman, Nathan A. Berger, editors.The obesity pandemic continues to increase on a world-wide basis with over 70% of the United States population being either overweight or obese. Hematologic malignancies have recently been identified among the obesity associated malignancies spanning the lifespan from childhood to the elderly and include leukemia, myeloma, lymphoma and others. In addition to the etiologic association between obesity and hematologic malignancies, the presence of obesity has profound effects on therapy by impacting pharmacokinetics of chemotherapeutic agents, dose, adipocyte metabolism and drug distribution. These may be particularly important in hematopoietic stem cell transplantation. Another important aspect of the association of obesity with hematologic malignancies is the increased incidence of obesity in children who successfully complete therapy for acute lymphoblastic leukemia. This and other observations indicate important relations between the hematopoietic systems and fat metabolism. This volume on Energy Balance in Hematologic Malignancies will provide an important volume in this series and a basis for better understanding etiology, mechanisms, therapeutics implications and experimental approaches. This volume of energy balance and cancer will focus on the relation of obesity to hematologic malignancies, the epidemiology, potential mechanisms, and thereapeutic considerations including effects on pharmacologic and physical approaches as well as the delayed effects of therapy on energy balance.
- 2008 Springeredited by Patricia A. Donohoue.Molecular Physiology of Monogenic and Syndromic Obesities in Humans / Wendy K. Chung and Rudolph L. Leibel -- Leptin Signaling In the Brain / Ofer Reizes, Stephen C. Benoit, and Deborah J. Clegg -- Inactivating Melanocortin-4 Receptor Mutations and Human Obesity / Ya-Xiong Tao -- The Role of Central Melanocortins in Cachexia / Daniel L. Marks -- The Efferent Arm of the Energy Balance Regulatory Pathway: Neuroendocrinology and Pathology / Robert H. Lustig -- Adiponectin: A Multifunctional Adipokine / Kristen Clarke and Robert L. Judd -- The Role of the Gastrointestinal Hormones Ghrelin, Peptide YY and Glucagon-like Peptide-1 in the Regulation of Energy Balance / Ruben Nogueiras, Hilary Wilson, Diego Perez-Tilve and Matthias H. Tschöp -- The Role of Growth Hormone Secretagogues and Ghrelin in Feeding and Body Composition / Cyril Y. Bowers, Blandine Laferrère, David Hurley, and Johannes D. Veldhuis -- Interaction Between Physical Activity and Genetic Factors in Complex Metabolic Disease / Paul W. Franks and Stephen M. Roth -- 11ss-Hydroxysteroid Dehydrogenase Type 1 and Obesity / Roland H. Stimson and Brian R. Walker -- Prader-Willi Syndrome : A Model of Disordered Energy Homeostasis / Andrea Haqq -- Antipsychotic Medication-Induced Weight Gain and Risk for Diabetes and Cardiovascular Disease / John W. Newcomer -- Treatment of Insulin Resistance in Youth: The Role of Metformin / Molly Emott and Michael Freemark -- The Surgical Approach to Morbid Obesity / Edward E. Mason, Mohammad K. Jamal and Thomas O'Dorisio.
- 2012Jay Thomas Fitzgerald.Polyketides are a large class of structurally diverse natural products which posses a wide range of biological activities. Unfortunately, despite the potential utility of these compounds in the clinic, large scale production of many of these natural products from their native hosts remains a challenge. Additionally, due to their complexity, engineering better pharmacokinetic properties by traditional synthetic means is often challenging. A better understanding of the biosynthetic machinery which produces polyketides allows for optimization of their production and paves the way for bioactivity-based pathway reengineering. This work begins with an introduction detailing attempts to unravel the biosynthetic underpinnings of two key natural product families, the tetracyclines and the thiostreptons, with an eye toward ultimately reengineering the pathways. Then, our efforts to reconstruct and reengineer the biosynthesis and biological activity of the type II polyketides frenolicin and A-74528 are detailed. Successful reconstruction of a chimeric biosynthetic pathway to frenolicin B and subsequent reengineering of that pathway to produce novel frenolicin analogs is described. Then, the biological activity of these compounds both in vitro against the parasites Toxoplasma gondii and Plasmodium falciparum is discussed. Additional studies against Plasmodium berghi in mice show that frenolicin B is an effective antiparastic agent in vivo. Following this, engineering of a biosynthetic pathway to the novel antiviral agent A-74528 from S. sp. SANK 61196 is presented and the impact of various tailoring enzymes on metabolite production are explored.
- 2014 Springer Protocolsedited by Swati Nagar, Upendra A. Argikar, Donald J. Tweedie.Enzyme Kinetics in Drug Metabolism : Fundamentals and Applications -- Fundaments of Enzyme Kinetics -- Different Enzyme Kinetic Models -- Reversible Mechanisms of Enzyme Inhibitors and Resulting Clinical Significance -- Irreversible Enzyme Inhibition Kinetics and Drug-Drug Interactions -- Multi-Enzyme Kinetics and Sequential Metabolism -- Consideration of the Unbound Drug Concentration in Enzyme Kinetics -- Enzyme Kinetics of Oxidative Metabolism : Cytochromes P450 -- Enzyme Kinetics, Pharmacokinetics, Inhibition, and Regioselectivity of Aldehyde Oxidase -- Enzyme Kinetics of Conjugative Enzymes : PAPS -- Enzyme Kinetics of Uridine Diphosphate Glucuronosyltransferases (UGTs) -- Principles and Experimental Considerations for in vitro Transporter Interaction Assays -- Rationalising Under-Prediction of Drug Clearance from Enzyme and Transporter Kinetic Data : from in vitro Tools to Mechanistic Modeling -- The Structural Model for the Mass Action Kinetic Analysis of P-gp Mediated Transport Through Confluent Cell Monolayers -- Systems Biology Approaches to Enzyme Kinetics: Analyzing Network Models of Drug Metabolism -- Variability in Human in vitro Enzyme Kinetics -- Sources of Interindividual Variability -- Case Study 1. Practical Considerations with Experimental Design and Interpretation -- Case Study 2. Practical Analytical Considerations for Conducting in vitro Enzyme Kinetic Studies -- Case Study 3. Application of Basic Enzyme Kinetics to Metabolism Studies : Real Life Examples -- Case Study 4. Predicting the Drug Interaction Potential for Inhibition of CYP2C8 by Montelukast -- Case Study 5. Deconvoluting Hyperbilirubinemia: Differentiating Between Hepatotoxicity and Reversible Inhibition of UGT1A, MRP2 or OATP1B1 in Drug Development -- Case Study 6. Drug Transporters: in vitro Solutions for Translatable Outcomes -- Case Study 7. Compiled Aha Moments in Enzyme Kinetics: Authors' Experiences.
- 2013 SpringerCornelia M. Ulrich, Karen Steindorf, Nathan A. Berger, editors.Although it is well established that the worldwide pandemic of overweight and obesity has profound effects on promoting cancer, it is now recognized that alternative aspects of energy balance, namely physical activity and exercise have significant beneficial effects on all aspects of cancer across the spectrum from prevention through treatment and extending through survivorship. While the effect of physical activity and exercise on cancer may be partially mediated through obesity control, it is clear that considerable research is required and is ongoing at both the molecular and clinical levels to better understand the associated mechanisms and to develop optimal exercise strategies. This volume presents the effects of exercise on biological pathways in tumor growth, state of the art exercise strategies and cutting edge research focused on different cancers and patient groups. This important text will provide a basis for ongoing research, experimental approaches and application of evidence based practices to clinical care for patients with cancer.
- 2006 NCBI Bookshelfedited by Atul Mehta, Michael Beck and Gere Sunder-Plassmann.
- 2010 ClinicalKeyMitchell L. Halperin, Kamel S. Kamel, Marc B. Goldstein.Principles of acid-base physiology -- Tools to use to diagnose acid-base disorders -- Metabolic acidosis: clinical approach -- Metabolic acidosis due to a deficit of NaHCO₃ -- Ketoacidosis -- Metabolic acidosis: acid gain types -- Metabolic alkalosis -- Respiratory acid-base disturbances -- Sodium and waterphysiology -- Hyponatremia -- Hypernatremia -- Polyuria -- Potassium physiology -- Hypokalemia -- Hyperkalemia -- Hyperglycemia.
- 2009 Kargervolume editor, Toshikazu Yoshikawa.Genomics for food functionality and safety / Abe, K. -- Lipid metabolism and nutrigenomics : impact of sesame lignans on gene expression profiles and fatty acid oxidation in rat liver / Ide, T. ... [et al.] -- Genome science of lipid metabolism and obesity / Takahashi, N. ... [et al.] -- Oxidative stress-induced posttranslational modification of proteins as a target of functional food / Naito, Y., Yoshikawa, T. -- Absorption and function of dietary carotenoids / Nagao, A. -- Metabolism of flavonoids / Wang, Y., Ho, C.-T. -- [beta]-carotene degradation products : formation, toxicity, and prevention of toxicity / Siems, W. ... [et al.] -- Dietary flavonoids as antioxidants / Terao, J. -- Inflammatory components of adipose tissue as target for treatment of metabolic syndrome / Yu, R., Kim, C.-S., Kang, J.-H. -- Soybean isoflavones in bone health / Ishimi, Y. -- Probiotics in primary prevention of atopic dermatitis / Ji, G.E. -- Astaxanthin protects neuronal cells against oxidative damage and is a potent candidate for brain food / Liu, X., Osawa, T. -- Function of marine carotenoids / Miyashita, K. -- Exercise and food factors / Aoi, W. -- Molecular basis for cancer chemoprevention by green tea polyphenol EGCG / Tachibana, H. -- Chemoprevention by isothiocyanates : molecular basis of apoptosis induction / Nakamura, Y. -- Ginger-derived phenolic substances with cancer preventive and therapeutic potential / Kundu, J.K., Na, H.-K., Surh, Y.-J. -- Chemoprevention with phytochemicals targeting inducible nitric oxide synthase / Murakami, A. -- Chemoprevention of tocotrienols : the mechanism of antiproliferative effect / Wada, S.
- 2015 SpringerBart C.J.M. Fauser, Andrea R. Genazzani, editors.This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women?s health as well as interested GPs.
- 2010 ScienceDirectedited by Minoru Fukuda.
- 2012 Springer Protocolsedited by Nancy P. Keller, Geoffrey Turner.Library preparation and data analysis packages for rapid genome sequencing -- Bioinformatics approaches and software for detection of secondary metabolic gene clusters -- Media and growth conditions for induction of secondary metabolite production -- Manipulating filamentous fungus chemical phenotypes by growth on nutritional arrays -- The "FERMEX" Method for metabolite-enriched fungal extracts -- The chemical identification and analysis of aspergillus nidulans secondary metabolites -- Detection and purification of non-ribosomal peptide synthetase products in Neosartorya fischeri -- Production, detection, and purification of clavine-type ergot alkaloids -- Analysis of volatile compounds emitted by filamentous fungi using solid-phase microextraction-gas chromatography/mass spectrometry -- Tools for manipulation of secondary metabolism pathways: Rapid promoter replacements and gene deletions in Aspergillus nidulans -- Fast and easy method for construction of plasmid vectors using modified quick-change mutagenesis -- Reconstitution of a secondary metabolite biosynthetic pathway in a heterologous fungal host -- Multi-copy genetic screen in Aspergillus nidulans -- Identification of protein complexes from filamentous fungi with tandem affinity purification -- Correlating secondary metabolite production with genetic changes using differential analysis of 2d NMR spectra -- Chromatin immunoprecipitation analysis in filamentous fungi -- Targeted proteomics for metabolic pathway optimization -- Investigation of in vivo protein interactions in Aspergillus spores -- Purification of a vesicle-vacuole (v) fraction from Aspergillus -- Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi -- Molecular analysis of fungal gene expression upon interkingdom competition with insects.
- 2006 CRCnetBASEedited by Anthony H. Futerman and Ari Zimran.Chapter 1. Introduction: Overview and Historical Perspective / Roscoe O. Brady -- Chapter 2. Gaucher Disease: Molecular Biology and Genotype-Phenotype Correlations / Kathleen S. Hruska, Mary E. LaMarca, and Ellen Sidransky -- Chapter 3. Cell Biology and Biochemistry of Acid β-Glucosidase: The Gaucher Disease Enzyme / Gregory A. Grabowski, Andrzej Kazimierczuk, and Benjamin Liou -- Chapter 4. Saposin C and Other Sphingolipid Activator Proteins / Silvia Locatelli Hoops, Thomas Kolter, and Konrad Sandhoff -- Chapter 5. The X-Ray Structure of Human Acid-β-Glucosidase: Implications for Second-Generation Enzyme Replacement Therapy / Lakshmanane Premkumar, Israel Silman, Joel L. Sussman, and Anthony H. Futerman -- Chapter 6. Cellular Pathology in Gaucher Disease / Anthony H. Futerman -- Chapter 7. The Biochemistry and Cellular Biology of Sphingolipids and Glucosylceramide / James A. Shayman -- Chapter 8. The Development of Enzyme Replacement Therapy for Lysosomal Diseases: Gaucher Disease and Beyond / Edward H. Schuchman and Silvia Muro -- Chapter 9. Gaucher Disease Animal Models / Ying Sun, You-Hai Xu, and Gregory A. Grabowski -- Chapter 10. Type 1 Gaucher Disease - Clinical Features / Pramod K. Mistry and Ari Zimran -- Chapter 11. Neuronopathic Gaucher Disease / Raphael Sc hiffmann and Ashok Vellodi -- Chapter 12. Pathologic Anatomy of Gaucher Disease: A Pictorial Essay / Robert E. Lee -- Chapter 13. Neuropathological Aspects of Gaucher Disease / Kondi Wong -- Chapter 14. Diagnosis and Laboratory Features / Carla E.M. Hollak and Johannes M.F.G. Aerts -- Chapter 15. Imaging in Gaucher Disease, Focusing on Bone Pathology / Mario Maas and Erik M. Akkerman -- Chapter 16. Radionuclide Evaluation of Gaucher Disease / Giuliano Mariani and Paola A. Erba -- Chapter 17. Epidemiology and Screening Policy / Peter J. Meikle, Maria Fuller, and John J. Hopwood Chapter 18. Enzyme Replacement Therapy for Type I Gaucher Disease / Ari Zimran, Bruno Bembi, and Gregory M. Pastores -- Chapter 19. Substrate Reduction Therapy / Frances M. Platt and Timothy M. Cox -- Chapter 20. Pharmacologic Chaperone Therapy for Lysosomal Diseases / Robert J. Desnick and Jian-Qiang Fan -- Chapter 21. The Significance of the Blood-Brain Barrier for Gaucher Disease and Other Lysosomal Storage Diseases / David J. Begley -- Chapter 22. Hematopoietic Stem Cell Transplantation, Stem Cells, and Gene Therapy / Charles Peters and William Krivit -- Chapter 23. Ethical Concerns in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avraham Steinberg -- Chapter 24. Societal Aspects in Treating Rare Diseases with Expensive Therapy / Deborah Elstein and Avi Israeli -- Chapter 25. Gaucher Disease as a Model for an Orphan Disease: Medical Aspects / Jill Waalen and Ernest Beutler -- Chapter 26. Meeting the Needs of Patients with Gaucher Disease: Pioneering a Sustainable Model for Ultra-Orphan Diseases / David P. Meeker and Henri A. Termeer -- Chapter 27. Patients' Perspective / Susan Lewis, Tanya Collin-Histed, Jeremy Manuel, and Greg Macres -- Chapter 28. Societal Perspective: Comment / Abby Alpert, Alan M. Garber, and Dana P. Goldman -- Chapter 29. Gaucher Associations Around the World.
- 2012Dennis Jacob Bua.The physiological state of the genome is chromatin. Chromatin is a dynamic polymer composed of genomic DNA, histone proteins, and other factors. Dysregulation of chromatin homeostasis can lead to diverse human pathologies including cancer. This work focuses on chromatin-based mechanisms of gene regulation; more specifically the (1) targeting and (2) stabilization of gene-regulatory proteins on the chromatin template. In regard to chromatin targeting, not much is known about how gene-regulatory proteins selectively associate with their targets. Herein we detail the discovery of a new targeting factor, the nuclear phospholipid phosphatidylinositol-5-phosphate (PtdIns(5)P). PtdIns(5)P directly interacts with the tumor suppressor ING2 (inhibitor of growth family member 2) in the nucleus to coordinate gene expression of select ING2 targets. In regard to chromatin stabilization, lysine methylation is a principle mechanism for retaining chromatin-effector modules at discrete chromatin zones. Numerous lysine methylation events have been discovered on the major protein component of chromatin, histones, but relatively few specific modules have been characterized to sense these modifications. We screened through a library of putative methyl-lysine binding domains, which resulted in the identification of three novel chromatin binding modules. Taken together these data shed insight into the molecular modes of action of gene regulation by chromatin and phosphoinositide pathways.
- 2012Paul G. Rack.The activation of the Hedgehog (Hh) pathway leading to Gli-dependent transcription plays critical roles in tissue patterning, homeostasis, and transformation. Despite the initial discovery of the pathway 30 years ago, a complete mechanistic understanding of Hh signal transduction remains elusive. By conducting a genome-scale overexpression screen using mammalian open reading frames (ORFs), I have identified the Rho GAP domain-containing protein Arhgap36, the homeodomain-interacting protein kinase Hipk4, and MED26, a subunit of the Mediator complex, as regulators of Gli function. This study represents the first report describing a functional role of Arhgap36 in any signaling process, and demonstrates Hipk4 modulates the cellular response to Hh ligand. The activity of MED26 was revealed in the context of the small molecule Hedgehog Pathway Inihibitor-1 (HPI-1), giving further insight to its mechanism of action. In addition, we describe the relevant mechanism of action of the small molecule JK184, a microtubule-disrupting agent that can have both positive and negative effects on pathway activity, depending on the nature of pathway perturbation. These findings provide new insights into how cells regulate Gli-dependent transcription and suggest strategies for the therapeutic intervention of Hh pathway-dependent disease.
- 2012 SpringerKarsten Suhre, editor.
- 2014 SpringerStruan F.A. Grant, editor.In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
- Genomic approaches for cross-species extrapolation in toxicology : proceedings from the Workshop on Emerging Molecular and Computational Approaches for Cross-Species Extrapolations, 18-22 July 2004, Portland, Oregon, USA2007 CRCnetBASEedited by William H. Benson and Richard T. Di Giulio."Omics" approaches in the context of environmental toxicology / Jon C. Cook ... [et al.] -- Selection of surrogate animal species for comparative toxicogenomics / Nancy D. Denslow ... [et al.] -- Species differences in response to toxic substances: shared pathways of toxicity--value and limitations of omics technologies to elucidate mechanism or mode of action / David Eaton ... [et al.] -- Bioinformatic approaches and computational models for data integration and cross-species extrapolation in the postgenomic era / Kenneth S. Ramos ... [et al.] -- The extension of molecular and computational information to risk assessment and regulatory decision making / James S. Bus ... [et al.].
- 2012 SpringerRoy G. Smith, Michael O. Thorner, editors.Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
- 2011 ScienceDirectedited by Debasis Bagchi.Chapter 1. Pediatric Obesity: A Pediatrician's Viewpoint / Allison Collins, Rebecka Peebles -- Chapter 2. Salient Features on Child Obesity from the Viewpoint of a Nutritionist / Bernard Waysfeld, Dominique Adele Cassuto -- Chapter 3. Developmental Trajectories of Weight Status in Childhood and Adolescence / Samar Hejazi, V. Susan Dahinten, Pamela A. Ratner, Sheila K. Marshall -- Chapter 4. The Measurement and Epidemiology of Child Obesity / David S. Freedman, Cynthia L. Ogden, Sarah E. Cusick -- Chapter 5. Good-Enough Parenting, Self-Regulation, and the Management of Weight-Related Problems / Moria Golan -- Chapter 6. Nursing Perspective on Childhood Obesity / Cynthia Yensel, Carrie Tolman -- Chapter 7. Contemporary Racial/Ethnic and Socioeconomic Patterns in U.S. Childhood Obesity / Gopal K. Singh, Michael D. Kogan -- Chapter 8. Prediabetes among Obese Youth / Orit Pinhas-Hamiel, Phil Zeitler -- Chapter 9. Prediabetes and Type 2 Diabetes: An Emerging Epidemic among Obese Youth / Kathryn Love-Osborne -- Chapter 10. Prevalence of the Metabolic Syndrome in U.S. Youth / Sarah E. Messiah, Kristopher L. Arheart, Steven E. Lipshultz, Tracie L. Miller -- Chapter 11. Emerging Pathways to Child Obesity Starts from the Mother's Womb: A Prospective View / Ashik Mosaddik -- Chapter 12. The Social, Cultural and Familial Contexts Contributing to Childhood Obesity / Cathy Banwell, Helen Kinmonth, Jane Dixon -- Chapter 13. Cardiovascular Risk Clustering in Obese Children / Ram Weiss -- Chapter 14. A Link between Maternal and Childhood Obesity / Siân Robinson -- Chapter 15. Is Prenatal Exposure to Maternal Obesity Linked to Child Mental Health? / Alina Rodriguez -- Chapter 16. Sleep and Obesity in Children and Adolescents / Amy Darukhanavala, Silvana Pannain -- Chapter 17. Cellular Remodeling during the Growth of the Adipose Tissue / Coralie Sengenès, Virginie Bourlier, Jean Galitzky, Alexia Zakaroff-Girard, Max Lafontan, Anne Bouloumié -- Chapter 18. Children Obesity, Glucose Tolerance, Ghrelin, and Prader-Willi Syndrome / Simonetta Bellone, Arianna Busti, Sara Belcastro, Gianluca Aimaretti, Gianni Bona, Flavia Prodam -- Chapter 19. Insulin Resistance and Glucose Metabolism in Childhood Obesity / Subhashini Yaturu, Sushil K. Jain -- Chapter 20. Insulin Resistance in Pediatric Obesity: Physiological Effects and Possible Diet Treatment / Ulf Holmbäck -- Chapter 21. Role of Fatty Liver Disease in Childhood Obesity / Valerio Nobili, Anna Alisi, Melania Manco -- Chapter 22. An Overview of Psychosocial Symptoms in Obese Children / Lisa Y. Gibson -- Chapter 23. Childhood Obesity: Depression, Anxiety and Recommended Therapeutic Strategies / Dana L. Rofey, Jessica J. Black, Jennifer E. Phillips, Ronette Blake, KayLoni Olson -- Chapter 24. The Emotional Impact of Obesity on Children / Robert E. Cornette -- Chapter 25. Psychiatric Illness, Psychotropic Medication, and Childhood Obesity / Lawrence Maayan, Leslie Citrome -- Chapter 26. Childhood Obesity: Public Health Impact and Policy Responses / Rogan Kersh, Brian Elbel -- Chapter 27. Childhood Obesity and Juvenile Diabetes / Mikael Knip -- Chapter 28. Bone Health in Obesity and the Cross Talk between Fat and Bone / Sowmya Krishnan, Venkataraman Kalyanaraman -- Chapter 29. A Community-Level Perspective for Childhood Obesity Prevention / Christina Economos, Erin Hennessy -- Chapter 30. School-Based Obesity-Prevention Programs / Genevieve Fridlund Dunton, Casey P. Durand, Nathaniel R. Riggs, Mary Ann Pentz -- Chapter 31. School-Based Obesity Prevention Interventions Show Promising Improvements in the Health and Academic Achievements among Ethnically Diverse Young Children / Danielle Hollar, Sarah E. Messiah, Gabriela Lopez-Mitnik, T. Lucas Hollar, Michelle Lombardo -- Chapter 32. School and Community-Based Physical Education and Healthy Active Living Programs: Holistic Practices in Hong Kong, Singapore, and the United States / Ming-Kai Chin, Christopher R. Edginton, Mei-Sin Tang, Kia-Wang Phua, Jing-Zhen Yang -- Chapter 33. Schools as “Laboratories” for Obesity Prevention: Proven Effective Models / Michelle Lombardo, Danielle Hollar, T. Lucas Hollar, Karen McNamara -- Chapter 34. Fitness and Fatness in Childhood Obesity: Implications for Physical Activity / Sarah P. Shultz, Benedicte Deforche, Nuala M. Byrne, Andrew P. Hills -- Chapter 35. Pharmacotherapy in Childhood Obesity / Amélio F. Godoy-Matos, Erika Paniago Guedes, Luciana Lopes de Souza, Mariana Farage -- Chapter 36. Beverage Interventions to Prevent Child Obesity / Rebecca Muckelbauer, Mathilde Kersting, Jacqueline Müller-Nordhorn -- Chapter 37. Psychotherapy as an Intervention for Child Obesity / Carl-Erik Flodmark -- Chapter 38. Childhood Obesity: Psychological Correlates and Recommended Therapeutic Strategies / Jennifer E. Phillips, Ethan E. Hull, Dana L. Rofey -- Chapter 39. Dietary Supplements in the Prevention and Treatment of Childhood Obesity / Robert I-San Lin -- Chapter 40. The Role of Arginine for Treating Obese Youth / Catherine J. McNeal, Guoyao Wu, Susie Vasquez, Don P. Wilson, M. Carey Satterfield, Jason R. McKnight, Hussain S. Malbari, Mujtaba Rahman -- Chapter 41. Prevention of Childhood Obesity with Use of Natural Products / Jin-Taek Hwang, Dae Young Kwon, Joohun Ha -- Chapter 42. The Role of United States Law to Prevent and Control Childhood Obesity / Jennifer L. Pomeranz -- Chapter 43. Childhood Obesity as an Amplifier of Societal Inequality in the United States / Stanley J. Ulijaszek -- Chapter 44. Childhood Obesity, Food Choice and Market Influence / Jane Kolodinsky, Amanda Goldstein, Erin Roche -- Chapter 45. The Role of Media in Childhood Obesity / Amy B. Jordan, Ariel Chernin -- Chapter 46. Evaluation and Management of Childhood Obesity in Primary Care Settings / Goutham Rao -- Chapter 47. The Future Directions and Clinical Management of Childhood Obesity / Clodagh S. O'Gorman, Jonathan Cauchi, Jill K. Hamilton, Denis Daneman.
- 2014 SpringerMirto Foletto, Raul J. Rosenthal, editors ; foreword by Nicola Scopinaro.The increasing prevalence of morbid obesity has led the World Health Organization to coin the descriptive term "globesity" to reflect the worldwide nature of the problem. Providing health care to these patients, especially when surgery is required, can be extremely challenging owing to the specific needs in respect of logistics, facilities, and professional expertise. Appropriate care has too often been unachievable and unaffordable outside of established bariatric centers, but such centers themselves usually have insufficient capacity and resources to cope with growing demand. This book aims to provide guidance and helpful tips and tricks on how to deal with obese patients within a general surgery setting. Epidemiology, organizational and logistical aspects, nursing issues, patient assessment, anesthesiology, and surgical practicalities are expertly covered in the opening chapters. Techniques of relevance to the general surgeon are described according to anatomic region, covering the head and neck; cardiothoracic and vascular system; upper and lower GI tract; pancreas, liver and adrenal glands; urinary tract and kidneys; the reproductive system; and the abdominal wall. Results achieved by bariatric surgery worldwide are reviewed, and the book closes with a chapter devoted to plastic and reconstructive surgery. The Globesity Challenge to General Surgery highlights a need for global rethinking on public health as regards resource allocation and patterns and standards of care, improving outcomes through greater affordability.
- 2015 SpringerJen-Chywan Wang, Charles Harris, editors.This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.Also available: Print – 2015
- 2010 ScienceDirectedited by Minoru Fukuda.
- 2011 CRCnetBASEby George A. Bray.Origins of obesity in the scientific era : 1500 AD to the present -- Definitions, measurement, and prevalence -- Genetic, metabolic, and social origins of obesity -- Effects of obesity on health and metabolism -- Prevention, evaluation, and introduction to treatment -- Lifestyle, diet, & exercise : cognitive solutions -- Medications for obesity -- Surgery for obesity -- Post-script : obesity in the twenty first century.
- 2008 Springeredited by Elissa Jelalian, Ric G. Steele.Pediatric obesity: trends and epidemiology / Ric G. Steele, Timothy D. Nelson, and Elissa Jelaian -- Health consequences of obesity in children and adolescents / Patrick Vivier and Christine Tompkins -- Psychological factors related to obesity in children and adolescents / Meg H. Zeller and Avani C. Modi -- Binge eating among children and adolescents / Marian Tanofsky-Kraff -- The definition and assessment of childhood overweight: a development perspective / Chermaine Tyler and Ginny Fullerton -- Diet assessment in children and adolescents / Nancy E. Sherwood -- Development of eating patterns / Vicky Phares, Jessica Curley, and Ariz Rojas -- Physiological mechanisms impacting weight regulation / David Fields and Paul Higgins -- Socioeconomic factors related to obesity in children and adolescents / Elizabeth Goodman -- The obesogenic environment / Amy A. Gorin and Melissa M. Crane -- Application of genetic epidemiology to understanding pediatric obesity / Robert Mair and Stephen T. McGarvey -- Development considerations in the prevention of pediatric obesity / Melissa Xanthopoulos, Chantelle Hart, and Elissa Jelalian -- Evidence-based treatments for childhood obesity / Hollie A. Raynor -- Empirically supported treatment of overweight adolescents / Alan M. Delamater ... [et al.] -- Intensive therapies for the treatment of pediatric obesity / Joan C. Han and Jack A. Yanovski -- Residential treatment programs for pediatric obesity / Paul J. Gately and Carlton B. Cooke -- Model treatment programs / Ann McGrath Davis and Rochelle L. James -- Cultural considerations in the development of pediatric weight management interventions / Dawn K. Wilson and Heather Kitzman-Ulrich -- Prevention of childhood obesity in childcare settings / Barbara A. Dennison and Myles S. Faith -- Obesity prevention programs for school-aged children and adolescents / David M. Janicke, Bethany J. Sallinen, and Jessica C. White Plume -- Preventing childhood obesity through collaborative public health action in communities / Vicki L. Collie-Akers and Stephen B. Fawcett -- The role of public policy in addressing the pediatric obesity epidemic / Patricia B. Crawford ... [et al.] -- Application of innovative technologies in the prevention and treatment of overweight in children and adolescents / Deborah F. Tate -- Motivational interviewing and pediatric obesity / Robyn S. Mehlenbeck and Yana Markov Wember -- Treatment of children and adolescents with obesity and comorbid psychiatric conditions / Alan Zametkin, Alanna Jacobs, Jessica Parrish -- Application of empirically supported treatments to clinical settings / Craig A. Johnston and William T. Dalton III -- Future directions in pediatric obesity prevention and intervention: research and practice / Elissa Jelalian, Ric G. Steele, and Chad D. Jensen.
- 2009 SpringerAbel Lajtha (ed.) ; volume editors, Guido Tettamanti and Gianfresco Goracci.
- 2014 CRCnetBASE[edited by] George A. Bray, Claude Bouchard."Now in its third edition, The Handbook of Obesity: Epidemiology, Etiology, and Physiopathology offers comprehensive coverage of the biological, behavioural, and environmental determinants of obesity and how excess weight affects and exacerbates a range of comorbid conditions including diabetes, cardiovascular disease, diabetes, pulmonary function, arthritis, and cancer. The content of this new edition reflects our evolving understanding of the causes and consequences of obesity. The text now constitutes five sections: History and Prevalence, Biological Determinants, Behavioural Determinants, Environmental, Social, and Cultural determinants, Consequences of Obesity. We now have a much better understanding of internal, biological factors associated with the development of obesity and the new edition dedicates 18 chapters to discussing the role of internal mechanisms on weight gain including chapters discussing genotype, early fetal life and events, the regulation of energy balance, the role of adipose tissue, and energy costs, among others. The role of our individual behaviours and degrees to which these, as well as larger cultural and environmental factors, influence our eating and weight issues is now also better understood thanks to increased research. These sections look at the likes of our work culture, drinking, sleep duration, and changing eating behaviours, as well as government-level food policies, changing advertising practices, economic determinants, and cultural traits relating to weight gain. Finally, we are now increasingly aware of the damage excess weight has on our bodies and the role it plays in the development of disease. The many diseases that have obesity as important risk factors are discussed in 15 chapters and include heart disease, diabetes, metabolic syndrome, cancer, liver disease, and pulmonary function"--Provided by publisher.
- 2007 SpringerShiriki Kumanyika, Ross C. Brownson, editors ; foreword by David Satcher.Why obesity prevention? -- What is obesity? Definitions matter -- Descriptive epidemiology of obesity in the United States -- Costs of obesity -- Obesity prevention concepts and frameworks -- Consumer perspectives and consumer action -- The role of government in preventing obesity -- Planning and the built environment -- The food industry role in obesity prevention -- Media, marketing and advertising and obesity -- Global context of obesity -- Organizational change for obesity prevention-perspectives, possibilities and potential pitfalls -- Community-based approaches to obesity prevention: the role of environmental and policy change -- Health care system approaches to obesity -- Workplace approaches to obesity prevention -- Obesity prevention in school and group child care settings -- Individual behavior change -- Obesity risk factors and prevention in early life: pre-gestation through infancy -- Obesity prevention during preschool and elementary school-age years -- Obesity prevention during preadolescence and adolescence -- Obesity prevention during adulthood -- Obesity prevention: charting a course to a healthier future.
- Homocysteine in protein structure/function and human disease : chemical biology of homocysteine-containing proteins2013 SpringerHieronim Jakubowski.Excess of homocysteine, a product of the metabolism of the essential amino acid methionine, is associated with poor health, is linked to heart and brain diseases in general human populations, and accelerates mortality in heart disease patients. Neurological and cardiovascular abnormalities occur in patients with severe genetic hyperhomocysteinemia and lead to premature death due to vascular complications. Although it is considered a non-protein amino acid, studies over the past dozen years have discovered mechanisms by which homocysteine becomes a component of proteins. Homocysteine-containing proteins lose their normal biological function and become auto-immunogenic and pro-thrombotic. In this book, the author, a pioneer and a leading contributor to the field, describes up-to date studies of the biological chemistry of homocysteine-containing proteins, as well as pathological consequences and clinical implications of their formation. This is a comprehensive account of the broad range of basic science and medical implications of homocysteine-containing proteins for health and disease.
- 2014 Kargervolume editors, Patric J.D. Delhanty, Aart J. van der Lely.Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis / Kalsbeek, A.; Bruinstroop, E.; Yi, C.-X.; Klieverik, L.; Liu, J.; Fliers, E. -- The blood-brain barrier as a regulator of the gut-brain axis / Schaeffer, M.; Hodson, D.J.; Mollard, P. -- The brain modulates insulin sensitivity in multiple tissues / Parlevliet, E.T.; Coomans, C.P.; Rensen, P.C.N.; Romijn, J.A. -- The important role of sleep in metabolism / Copinschi, G.; Leproult, R. ; Spiegel, K. -- Metabolic interplay between gut bacteria and their host / Duca, F.; Giard, P.; Covasa, M.; Lepage, P. -- The brain-stomach connection / Folgueira, C.; Seoane, L.M.; Casanueva, F.F. -- Prader-Willi syndrome as a model of human hyperphagia / Tauber, M.; Diene, G.; Mimoun, E.; Aabal-Berthoumieu, S.; Mantoulan, C.; Molinas, C.; Muscatelli, F.; Salles, J.P. -- Interactions between the gut, the brain and brown adipose tissue function / van den Beukel, J.C.; Grefhorst, A. -- Gut sweet taste receptors and their role in metabolism / Meyer-Gerspach, A.C.; Wilnerhanssen, B.; Beglinger, C. -- What is the role of metabolic hormones in taste buds of the tongue / Cai, H.; Maudsley, S.; Martin, B. -- Protein PYY and its role in metabolism / Price, S.L.; Bloom, S.R. -- Nutropioids regulate the gut-brain circuit controlling food intake / Mithieux, G. -- Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? / Delhanty, P.J.D.; Neggers, S.J.; van der Lely, A.J. -- Obestatin : is it really doing something? / Trovato, L.; Gallo, D.; Settanni, F.; Gesmundo, I.; Ghigo, E.; Granata, R.
- 2008 SpringerBrian V. Reamy, editor ; foreword by Charles E. Henley.
- Hypothalamic integration of energy metabolism : proceedings of the 24th International Summer School of Arts and Sciences, Amsterdam, The Netherlands, 29 August - 1 September 2005. 1st ed.2006 ScienceDirectedited by A. Kalsbeek, E. Fliers, M.A. Hofman... [et al.].Also available: Print – 2006
- Identification and characterization of a novel polyubiquitin binding protein involved in virus maturation2012Dara P. Dowlatshahi.The covalent attachment of ubiquitin (Ub), a 76-amino-acid protein, to another protein is a highly occurring and conserved post-translational modification. Ub functions in a plethora of diverse signaling pathways including proteasomal degradation, endocytosis and trafficking of membrane receptors and DNA repair when conjugated to substrate proteins. Ub is unique in that it can also be conjugated to itself to create an assortment of polyubiquitin chains, through either its amino terminus or any of its seven internal lysines, where a large part of its diverse signaling is ascribed to these polyubiquitin chains. Previous work has identified proteins, which specifically recognize these different types of Ub linkages to contain domains or motifs termed Ub binding domains (UBDs). Studies on the various and diverse roles of Ub signaling along with its own diversity of conjugates present on substrates and their recognition by UBDs have uncovered the existence of a Ub syntax or code. The main goal of the work entailed in this thesis was to contribute to decryption of this code by identifying new linkage specific polyubiquitin binding proteins and characterizing their function and mechanism of polyubiquitin recognition. We developed and used a K63 linkage specific polyubiquitin affinity reagent in conjunction with shotgun LC-MS/MS to identify novel polyubiquitin binding proteins. We found that the majority of polyubiquitin dependent identified proteins were previously known Ub binders as well as a few previously unidentified Ub interacting proteins, demonstrating this as a valid approach for the identification of polyubiquitin binding proteins. One such previously unidentified protein we identified was ALIX, a a component of the Endosomal Sorting Complex Required for Transport (ESCRT) machinery known to be involved in Human Immunodeficiency Virus (HIV) budding. We characterized ALIX and found that it binds directly and selectively to K63-linked polyubiquitin via two potential Ub binding sites on a single [alpha]-helical surface within a coiled-coil region, where mutation of these sites impaired retroviral release. Our study demonstrates ALIX as the first example of a K63 chain specific polyubiquitin receptor in the endosomal sorting pathway that supplies evidence for a functional link between K63 polyubiquitin binding and ESCRT function, specifically in retrovirus budding. In summary the findings in our study contribute to the understanding of the role of K63-linked polyubiquitin in the ESCRT pathway. Our work also demonstrates the power of using unbiased affinity capture and tandem mass spectrometry to identify polyubiquitin receptor proteins to further decryption of the Ub code.
- Abdominal obesity--a driver of cardiometabolic risk — Identification and characterization of a novel polyubiquitin binding protein involved in virus maturation (100)
- IgE antibody dynamics and its role in receptor binding and inhibition — Physician's guide to the diagnosis, treatment, and follow-up of inherited metabolic diseases (100)
- Physician's guide to the treatment and follow-up of metabolic diseases — Yeast metabolic engineering : methods and protocols (51)
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