Books by Subject
- Advance in structural bioinformatics 2015SpringerThis text examines in detail mathematical and physical modeling, computational methods and systems for obtaining and analyzing biological structures, using pioneering research cases as examples. As such, it emphasizes programming and problem-solving skills. It provides information on structure bioinformatics at various levels, with individual chapters covering introductory to advanced aspects, from fundamental methods and guidelines on acquiring and analyzing genomics and proteomics sequences, the structures of protein, DNA and RNA, to the basics of physical simulations and methods for conformation searches. This book will be of immense value to researchers and students in the fields of bioinformatics, computational biology and chemistry. Dr. Dongqing Wei is a Professor at the Department of Bioinformatics and Biostatistics, College of Life Science and Biotechnology, Shanghai Jiaotong University, Shanghai, China. His research interest is in the general area of structural bioinformatics.
- Advances in mass data analysis of signals and images in medicine, biotechnology, and chemistry international conferences, MDA 2006/2007, Leipzig, Germany, July 18, 2007 : selected papers 2007Springer
- Advances in probabilistic graphical models 2007Springer
- Agent technology and e-health 2008Springer
- Applied medical statistics using SAS 2013CRCnetBASE"Adding topics useful to medical statisticians, this new edition of a popular intermediate-level reference explores the use of SAS for analyzing medical data. A new chapter on visualizing data includes a detailed account of graphics for investigating data and smoothing techniques. The book also includes new chapters on measurement in medicine, epidemiology/observational studies, meta-analysis, Bayesian methods, and handling missing data. The book maintains its example-based approach, with SAS code and output included throughout and available online"--Provided by publisher.
- Artificial intelligence with uncertainty 2008CRCnetBASE
- This assessment tool describes in detail how to undertake a first baseline assessment of a national HIS. The assessment process is intended to be both catalytic and synergistic. It should move stakeholders towards a shared and broader vision of a more coherent, integrated, efficient and useful system. The gap between the existing system and this new vision will be an important stimulus for moving to the next stage of planning national HIS reform. Such an assessment process can also be a mechanism for directly engaging stakeholders and for reinforcing broad-based consensus-building.--Publisher's description.
- Automated data analysis using Excel 2007CRCnetBASE
- Automated EEG-based diagnosis of neurological disorders inventing the future of neurology 2010CRCnetBASETime-frequency analysis : wavelet transforms -- Chaos theory -- Classifier designs -- Electroencephalograms and epilepsy -- Analysis of EEGs in an epileptic patient using wavelet transform -- Wavelet-chaos methodology for analysis of EEGs and EEG sub-bands -- Mixed-band wavelet-chaos neural network methodology -- Principal component analysis-enhanced cosine radial basis function neural network -- Alzheimer's disease and models of computation : imaging, classification, and neural models -- Alzheimer's disease : models of computation and analysis of EEGs -- A spatio-temporal wavelet-chaos methodology for EEG-based diagnosis of Alzheimer's disease -- Spiking neural networks : spiking neurons and learning algorithms -- Improved spiking neural networks with application to EEG classification and epilepsy and seizure detection -- A new supervised learning algorithm for multiple spiking neural networks -- Applications of multiple spiking neural networks : EEG classification and epilepsy and seizure detection.
- The book introduces the bioinformatics tools, databases and strategies for the translational research, focuses on the biomarker discovery based on integrative data analysis and systems biological network reconstruction. With the coming of personal genomics era, the biomedical data will be accumulated fast and then it will become reality for the personalized and accurate diagnosis, prognosis and treatment of complex diseases. The book covers both state of the art of bioinformatics methodologies and the examples for the identification of simple or network biomarkers. In addition, bioinformatics software tools and scripts are provided to the practical application in the study of complex diseases. The present state, the future challenges and perspectives were discussed. The book is written for biologists, biomedical informatics scientists and clinicians, etc.
- Bioinformatics for high throughput sequencing 2012SpringerOverview of sequencing technology platforms / Samuel Myllykangas, Jason Buenrostro, and Hanlee P. Ji -- Applications of high-throughput sequencing / Rodrigo Goya, Irmtraud M. Meyer, and Marco A. Marra -- Computational infrastructure and basic data analysis for high-throughput sequencing / David Sexton -- Base-calling for bioinformaticians / Mona A. Sheikh and Yaniv Erlich -- De novo short-read assembly / Douglas W. Bryant Jr. and Todd C. Mockler -- Short-read mapping / Paolo Ribeca -- DNA-protein interaction analysis (ChIP-Seq) / Geetu Tuteja -- Generation and analysis of genome-wide DNA methylation maps / Martin Kerick, Axel Fischer, and Michal-Ruth Schweiger -- Differential expression for RNA sequencing (RNA-Seq) data : mapping, summarization, statistical analysis, and experimental design / Matthew D. Young ... [et al.] -- MicroRNA expression profiling and discovery / Michael Hackenberg -- Dissecting splicing regulatory network by integrative analysis of CLIP-Seq data / Michael Q. Zhang -- Analysis of metagenomics data / Elizabeth M. Glass and Folker Meyer -- High-throughput sequencing data analysis software : current state and future developments / Konrad Paszkiewicz and David J. Studholme.
- Bioinformatics for omics data methods and protocols 2011Springer Protocols[Publisher-supplied data] Presenting an area of research that intersects with and integrates diverse disciplines, including molecular biology, applied informatics, and statistics, among others, Bioinformatics for Omics Data: Methods and Protocols collects contributions from expert researchers in order to provide practical guidelines to this complex study. Divided into three convenient sections, this detailed volume covers central analysis strategies, standardization and data-management guidelines, and fundamental statistics for analyzing Omics profiles, followed by a section on bioinformatics approaches for specific Omics tracks, spanning genome, transcriptome, proteome, and metabolome levels, as well as an assortment of examples of integrated Omics bioinformatics applications, complemented by case studies on biomarker and target identification in the context of human disease. Written in the highly successful Methods in Molecular Biology series format, chapters contain introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and notes on troubleshooting and avoiding known pitfalls. Authoritative and accessible, Bioinformatics for Omics Data: Methods and Protocols serves as an ideal guide to scientists of all backgrounds and aims to convey the appropriate sense of fascination associated with this research field.
- Bioinformatics-- the impact of accurate quantification on proteomic and genetic analysis and research 2014CRCnetBASE
- Biomedical informatics computer applications in health care and biomedicine.. Fourth edition. [4th ed.] / 2014SpringerBiomedical Informatics: Computer Applications in Health Care and Biomedicine meets the growing demand of practitioners, researchers, educators, and students for a comprehensive introduction to key topics in the field and the underlying scientific issues that sit at the intersection of biomedical science, patient care, public health, and information technology (IT). This 4th edition reflects the remarkable changes in both computing and health care that continue to occur and the exploding interest in the role that IT must play in care coordination and the melding of genomics with innovations in clinical practice and treatment. New chapters have been introduced on the health information infrastructure, consumer health informatics, telemedicine, translational bioinformatics, clinical research informatics, and health IT policy, while the others have all undergone extensive revisions, in many cases with new authors. The organization and philosophy are unchanged, focusing on the science of information and knowledge management and the role of computers and communications in modern biomedical research, health, and health care. Emphasizing the conceptual basis of the field rather than technical details, it provides an introduction and extensive bibliography so that readers can comprehend, assess, and utilize biomedical informatics and health IT. The volume focuses on easy-to-understand examples, a guide to additional literature, chapter summaries, and a comprehensive glossary with concise definitions of recurring terms for self-study or classroom use.
- Biomedical simulation 4th international symposium, ISBMS 2008, London, UK, July 7-8, 2008 : proceedings 2008Springer
- BYOD for healthcare 2014CRCnetBASE"Where once end users queued up to ask information technology (IT) permission to buy a new computer or new version of software, they are now bypassing IT altogether and buying it on their own. From laptops to smartphones. From iPads to any number of software apps, end users have tasted their freedom and love them. IT is just never going to be the same. Welcome to the brave new world of "bring your own devices" (BYODs). The roots of BYOD can be traced back to the consumerization of all things technology, where technical wizardry is no longer purely the domain of the geek who works for the IT department. Geeks can now be found all over the organization. These workers want to make their own technology choices, whether those choices are on the "approved" list or the company pays for it. Seventy percent of organizations have already adopted BYOD. Gartner predicts this number to increase to 90% by 2014. Most interestingly, a very high percentage of workers think that it is a right rather than a privilege to use their own devices at work. So, it is really not a question of if. It is not even a question of when. It is a question of will you be ready. Of course, the healthcare industry is not the same as most other industries. Hospitals, clinics, and medical offices are not stores, hotels, or assembly lines, although all of these industries are affected by the economy, productivity, regulation, and the need for assessment. hBYOD: Adapting BYOD for the Healthcare Industry provides the guidance necessary for living in this brave new world. You will first learn how to understand these new end users and their demands, as well as the strategic and tactical ramifications of these demands. BYOD will then cover the broad range of technical considerations such as selection, "-- Provided by publisher.
- Cancer informatics in the post genomic era 2007Springer
- CDAtm book 2011SpringerOrganization of This Book -- Clinical Documentation -- The HL7 Clinical Document Architecture -- Extensible Markup Language -- Basic Data Types -- Text and Multimedia -- Demographic Data -- Codes and Vocabularies -- Codes -- Dates and Times -- Collections -- HL7 Version 3 Modeling -- Clinical Document Infrastructure -- The CDAtm Header -- The CDAtm Body -- Clinical Statements in the CDAtm -- HL7 Version 2 to CDAtm Release 2 -- Extracting Data from a CDAtm Document -- Templates -- Validating the Content of a CDAtm Document -- Implementation Guides on CDAtm.
- Chemical library design 2011Springer ProtocolsHistorical overview of chemical library design / Roland E. Dolle -- Chemoinformatics and library design / Joe Zongxiang Zhou -- Molecular library design using multi-objective optimization methods / Christos A. Nicolaou and Christos C. Kannas -- A scalable approach to combinatorial library design / Puneet Sharma, Srinivasa Salapaka, and Carolyn Beck -- Application of Free-Wilson selectivity analysis for combinatorial library design / Simone Sciabola ... [et al.] -- Application of QSAR and shape pharmacophore modeling approaches for targeted chemical library design / Jerry O. Ebalunode, Weifan Zheng, and Alexander Tropsha -- Combinatorial library design from reagent pharmacophore fingerprints / Hongming Chen, Ola Engkvist, and Niklas Blomberg -- Docking methods for structure-based library design / Claudio N. Cavasotto and Sharangdhar S. Phatak -- Structure-based library design in efficient discovery of novel inhibitors / Shunqi Yan and Robert Selliah -- Structure-based and property-compliant library design of 11[beta]-HSD1 adamantyl amide inhibitors / Genevieve D. Paderes ... [et al.] -- Design of screening collections for successful fragment-based lead discovery / James Na and Qiyue Hu -- Fragment-based drug design / Eric Feyfant ... [et al.] -- LEAP into the Pfizer Global Virtual Library (PGVL) space : creation of readily synthesizable design ideas automatically / Qiyue Hu ... [et al.] -- The design, annotation, and application of a kinase-targeted library / Hualin Xi and Elizabeth A. Lunney -- PGVL hub : an integrated desktop tool for medicinal chemists to streamline design and synthesis of chemical libraries and singleton compounds / Zhengwei Peng ... [et al.] -- Design of targeted libraries against the human Chk1 kinase using PGVL hub / Xengwei Peng and Qiyue Hu -- GLARE : a tool for product-oriented design of combinatorial libraries / Jean-François Truchon -- CLEVER : a general design tool for combinatorial libraries / Tze Hau Lam ... [et al.].
- Chemoinformatics and computational chemical biology 2010Springer ProtocolsSome Trends in Chem(o)informatics / Wendy A. Warr -- Molecular Similarity Measures / Gerald M. Maggiora and Veerabahu Shanmugasundaram -- The Ups and Downs of Structure-Activity Landscapes / Rajarshi Guha -- Computational Analysis of Activity and Selectivity Cliffs / Lisa Peltason and Jurgen Bajorath -- Similarity Searching Using 2D Structural Fingerprints / Peter Willett -- Predicting the Performance of Fingerprint Similarity Searching / Martin Vogt and Jurgen Bajorath -- Bayesian Methods in Virtual Screening and Chemical Biology / Andreas Bender -- Reduced Graphs and Their Applications in Chemoinformatics / Kristian Birchall and Valerie J. Gillet -- Fragment Descriptors in Structure-Property Modeling and Virtual Screening / Alexandre Varnek -- The Scaffold Tree: An Efficient Navigation in the Scaffold Universe / Peter Ertl, Ansgar Schuffenhauer, and Steffen Renner -- Pharmacophore-Based Virtual Screening / Dragos Horvath -- De Novo Drug Design / Markus Hartenfeller and Gisbert Schneider -- Classification of Chemical Reactions and Chemoinformatics Processing of Enzymatic Transformations / Diogo A.R.S. Latino and Joao Aires-de-Sousa -- Informatics Approach to the Rational Design of siRNA Libraries / Jerry O. Ebalunode, Charles Jagun, and Weifan Zheng -- Beyond Rhodopsin: G Protein-Coupled Receptor Structure and Modeling Incorporating the b2-adrenergic and Adenosine A2A Crystal Structures / Andrew J. Tebben and Dora M. Schnur -- Methods for Combinatorial and Parallel Library Design / Dora M. Schnur, Brett R. Beno, Andrew J. Tebben, and Cullen Cavallaro -- The Interweaving of Cheminformatics and HTS / Anne Kummel and Christian N. Parker -- Computational Systems Chemical Biology / Tudor I. Oprea, Elebeoba E. May, Andrei Leitao, and Alexander Tropsha -- Ligand-Based Approaches to In Silico Pharmacology / David Vidal, Ricard Garcia-Serna, and Jordi Mestres -- Molecular Test Systems for Computational Selectivity Studies and Systematic Analysis of Compound Selectivity Profiles / Dagmar Stumpfe, Eugen Lounkine, and Jurgen Bajorath -- Application of Support Vector Machine-Based Ranking Strategies to Search for Target-Selective Compounds / Anne Mai Wassermann, Hanna Geppert, and Jurgen Bajorath -- What Do We Know?: Simple Statistical Techniques that Help / Anthony Nicholls.
- Clinical bioinformatics 2008Springer ProtocolsIn silico gene discovery / Bing Yu -- Whole genome-wide association study using Affymetrix SNP chip : a two-stage sequential selection method to identify genes that increase the risk of developing complex diseases / Howard H. Yang ... [et al.] -- Utilizing HapMap and tagging SNPs / Christopher A. Haiman and Daniel O. Stram -- Measuring the effects of genes and environment on complex traits / Jennifer H. Barrett -- Microarrays-planning your experiment / Jean Yee Hwa Yang -- Clinical uses of microarrays in cancer research / Carl Virtanen and James Woodgett -- Microarrays-analysis of signaling pathways / Anassuya Ramachandran ... [et al.] -- Microarrays-identifying molecular portraits for prostate tumors with different Gleason patterns / Alexandre Mendes, Rodney J. Scott, and Pablo Moscato -- Microarrays for the study of viral gene expression during human cytomegalovirus latent infection / Barry Slobedman and Allen K.L. Cheung -- Computer-assisted reading of DNA sequences / Huong Le ... [et al.] -- Evaluating DNA sequence variants of unknown biological significance / Scott A. Grist, Andrew Dubowsky, and Graeme Suthers -- Developing a DNA variant database / David C.Y. Fung -- Protein comparative sequence analysis and computer modeling / Brett D. Hambly, Cecily E. Oakley, and Piotr G. Fajer -- Identification and characterization of microbial proteins using peptide mass fingerprinting strategies / Jonathan W. Arthur -- Statistical analysis of image data provided by two-dimensional gel electrophoresis for discovery proteomics / Ben Crossett ... [et al.] -- Online resources for the molecular contextualization of disease / Chi N.I. Pang and Marc R. Wilkins -- Web-based resources for clinical bioinformatics / Anthony M. Joshua and Paul C. Boutros -- Developing decision support systems in clinical bioinformatics / Vitali Sintchenko and Enrico Coiera -- eConsulting / Siaw-Teng Liaw and Peter Schattner.
- Overview of clinical decision support systems / Eta S. Berner and Tonya J. La Londe -- Mathematical foundations of decision support systems / S. Andrew Spooner -- Data mining and clinical decision support systems / J. Michael Hardin and David C. Chhieng -- Design and implementation issues / Jerome H. Carter -- Diagnostic decision support systems / Randolph A. Miller and Antoine Geissbuhler -- Ethical and legal issues in decision support / Kenneth W. Goodman -- Clinical trials of information interventions / E. Andrew Balas and Suzanne Austin Boren -- Clinical decision support at Intermountain Healthcare / Peter J. Haug ... [et al.] -- Clinical decision support within the Regenstrief medical record system / Burke W. Mamlin ... [et al.] -- Decision support during inpatient care provider order entry : the Vanderbilt experience / Randolph A. Miller ... [et al.] -- Decision support for patients / Holly B. Jimison, Paul P. Sher, Jennifer J.B. Jimison.
- 2014 ClinicalKeySect. 1: Computer-based clinical decision support: overview, status, and challenges. Ch. 1. Definition, scope and challenges / Robert A. Greenes -- Ch. 2. A brief history of clinical decision support / Robert A. Greenes -- Ch. 3. Features of computer-based clinical decision support / Robert A. Greenes -- Ch. 4. The role of quality measurement and reporting feedback as a driver for care improvement / Floyd Eisenberg -- Sect. 2: Experience with CDS development and adoption : case studies, national initiatives, and lessons learned. Ch. 5. Regenstrief medical informatics / Paul Biondich, [et al.] -- Ch. 6. Patients, doctors, and information technology : clinical decision support at Brigham and Women's Hospital and Partners HealthCare / Adam Wright and David W. Bates -- Ch. 7. Computer-based approaches to improving healthcare quality and safety at LDS Hospital / R. Scott Evans -- Ch. 8. International dimensions of clinical decision support / Hamish Fraser and Jeremy Wyatt -- Ch. 9. Current state of CDS utilization / Robert A. Greenes -- Sect. 3: Sources of knowledge for clinical decision support. Ch. 10. Human-intensive techniques / Vimla L. Patel and Edward H. Shortliffe -- Ch. 11. Generation of knowledge for clinical decision support / Michael E. Matheny and Lucila Ohno-Machado -- Ch. 12. Modernizing evidence synthesis for evidence-based medicine / Byron C. Wallace, [et al.] -- Ch. 13. Big data and population-based decision support / Michael A. Krall, Adi V. Gundlapalli and Matthew H. Samore -- Ch. 14. Clinical decision support for personalized medicine / Brandon M. Welch, [et al.]. Sect. 4: The technology of clinical decision support. Ch. 15. Decision rules and expressions / Robert A. Jenders -- Ch. 16. Guidelines and workflow models / Mor Peleg and Arturo González-Ferrer -- Ch. 17. Ontologies, vocabularies and data models / Stanley M. Huff, [et al.] -- Ch. 18. Grouped knowledge elements / Margarita Sordo and Aziz A. Boxwala -- Ch. 19. Infobuttons and point of care access to knowledge / Guilherme Del Fiol, Hong Yu and James J. Cimino -- Ch. 20. Formal representations and semantice web technologies / Alan Rector and Davide Sottara -- Ch. 21. The role of standards / Kensaku Kawamoto and Robert A. Greenes -- Sect. 5: Adoption of clinical decision support. Ch. 22. Cognitive considerations for health information technology / Amy Franklin and Jiajie Zhang -- Ch. 23. Organizational and cultural change / Joan S. Ash and Timothy H. Hartzog -- Ch. 24. Managing the investment in clinical decision support / John Glaser and Tonya Hongsermeier -- Ch. 25. A clinical decision support implementation guide : practical considerations / Donald Levick and Jerome Osheroff -- Ch. 26. Legal and regulatory issues related to the use of clinical software in health care delivery / Steven H. Brown and Randolph A. Miller -- Ch. 27. Consumers and clinical decision support / Nananda Col and Rosaly Correa-de-Araujo -- Sect. 6: The journey to widespread use of clinical decision support. Ch. 28. A clinical knowledge management program / Roberto A. Rocha, [et al.] -- Ch. 29. Integration of knowledge resources into applications to enable CDS / Kensaku Kawamoto, Emory Fry and Robert Greenes -- Ch. 30. Looking ahead : the road to broad adoption / Robert A. Greenes.
- Clinical research informatics 2012Springer"This book provides foundational coverage of key areas, concepts, constructs, and approaches of medical informatics as it applies to clinical research activities, in both current settings and in light of emerging policies. The field of clinical research is fully characterized (in terms of study design and overarching business processes), and there is emphasis on information management aspects and informatics implications (including needed activities) within various clinical research environments. The purpose of the book is to provide an overview of clinical research (types), activities, and areas where informatics and IT could fit into various activities and business practices. This book introduces and applies informatics concepts only as they have particular relevance to clinical research settings"--Provided by publisher.
- Cloud-based solutions for healthcare IT 2011CRCnetBASE1. What are cloud services? -- 2. Benefits and drawbacks of cloud services -- 3. Cloud technologies -- 4. Cloud-based solutions for healthcare IT -- 5. HIPAA and HITECH : cloud perspective -- 6. Adopting cloud services -- 7. Interoperability -- 8. Cloud-based personal health records (PHR) -- 9. Case studies.
- Cognitive informatics in health and biomedicine case studies on critical care, complexity and errors 2014Springer"Enormous advances in information technology have permeated essentially all facets of life in the past two decades. Formidable challenges remain in fostering tools that enhance productivity but are sensitive to work practices. Cognitive Informatics (CI) is the multidisciplinary study of cognition, information and computational sciences that investigates all facets of human computing including design and computer-mediated intelligent action, thus is strongly grounded in methods and theories from cognitive science. As an applied discipline, it has a close affiliation with human factors and human-computer interaction, and provides a framework for the analysis and modeling of complex human performance in technology-mediated settings and contributes to the design and development of better information systems. In recent years, CI has emerged as a distinct area with special relevance to biomedicine and health care. In addition, it has become a foundation for education and training of health informaticians, the Office of the National Coordinator for Health Information Technology initiating a program including CI as one of its critical elements to support health IT curriculum development. This book represents a first textbook on cognitive informatics and will focus on key examples drawn from the application of methods and theories from CI to challenges pertaining to the practice of critical-care medicine (CCM). Technology is transforming critical care workflows and re-organizing patient care management processes. CCM has proven to be a fertile test bed for theories and methods of cognitive informatics. CI, in turn, has contributed much to our understanding of the factors that result in complexity and patient errors. The topic is strongly interdisciplinary and will be important for individuals from a range of academic and professional backgrounds, including critical care specialists, psychologists, computer scientists, medical informaticians, and anthropologists"--Provided by publisher.
- Comprehensive textbook of healthcare simulation 2013SpringerPart I. Introduction to simulation -- Part II. Simulation modalities and technologies -- Part III. Simulation for healthcare disciplines -- Part IV. Professional development in simulation -- Part V. Program development in simulation -- Appendices -- Index.
- Computational and statistical epigenomics 2015SpringerThis book introduces the reader to modern computational and statistical tools for translational epigenomics research. Over the last decade, epigenomics has emerged as a key area of molecular biology, epidemiology and genome medicine. Epigenomics not only offers us a deeper understanding of fundamental cellular biology, but also provides us with the basis for an improved understanding and management of complex diseases. From novel biomarkers for risk prediction, early detection, diagnosis and prognosis of common diseases, to novel therapeutic strategies, epigenomics is set to play a key role in the personalized medicine of the future. In this book we introduce the reader to some of the most important computational and statistical methods for analyzing epigenomic data, with a special focus on DNA methylation. Topics include normalization, correction for cellular heterogeneity, batch effects, clustering, supervised analysis and integrative methods for systems epigenomics. This book will be of interest to students and researchers in bioinformatics, biostatistics, biologists and clinicians alike. Dr. Andrew E. Teschendorff is Head of the Computational Systems Genomics Lab at the CAS-MPG Partner Institute for Computational Biology, Shanghai, China, as well as an Honorary Research Fellow at the UCL Cancer Institute, University College London, UK.
- Computational biology a practical introduction to biodata processing and analysis with Linux, MySQL, and R. 2nd ed. 2013SpringerThis greatly expanded 2nd edition provides a practical introduction to - data processing with Linux tools and the programming languages AWK and Perl- data management with the relational database system MySQL, and- data analysis and visualization with the statistical computing environment R for students and practitioners in the life sciences. Although written for beginners, experienced researchers in areas involving bioinformatics and computational biology may benefit from numerous tips and tricks that help to process, filter and format large datasets. Learning by doing is the basic concept of this book. Worked examples illustrate how to employ data processing and analysis techniques, e.g. for - finding proteins potentially causing pathogenicity in bacteria, - supporting the significance of BLAST with homology modeling, or- detecting candidate proteins that may be redox-regulated, on the basis of their structure. All the software tools and datasets used are freely available. One section is devoted to explaining setup and maintenance of Linux as an operating system independent virtual machine. The author's experiences and knowledge gained from working and teaching in both academia and industry constitute the foundation for this practical approach.
- Computational genomic signatures 2011AtyponRecent advances in development of sequencing technology has resulted in a deluge of genomic data. In order to make sense of this data, there is an urgent need for algorithms for data processing and quantitative reasoning. An emerging in silico approach, called computational genomic signatures, addresses this need by representing global species-specific features of genomes using simple mathematical models. This text introduces the general concept of computational genomic signatures, and it reviews some of the DNA sequence models which can be used as computational genomic signatures. The text takes the position that a practical computational genomic signature consists of both a model and a measure for computing the distance or similarity between models. Therefore, a discussion of sequence similarity/distance measurement in the context of computational genomic signatures is presented. The remainder of the text covers various applications of computational genomic signatures in the areas of metagenomics, phylogenetics and the detection of horizontal gene transfer.
- Computational medicine tools and challenges 2012SpringerBioinformatic Tools for the Search of Disease-Associated Variations / Stefan Coassin, Anita Kloss-Brandstätter and Florian Kronenberg -- Cloud Computing / Bringing Computational Power to Medical Genetics / Lukas Forer, Sebastian Schönherr, Hansi Wei€ensteiner, Günther Specht and Florian Kronenberg, et al. -- High-Throughput Characterization and Comparison of Microbial Communities / Bettina Halwachs, Gregor Gorkiewicz and Gerhard G. Thallinger -- Microarray Meta-Analysis: From Data to Expression to Biological Relationships / Julia Feichtinger, Gerhard G. Thallinger, Ramsay J. McFarlane and Lee D. Larcombe -- Analysis of Labeled Quantitative Mass Spectrometry Proteomics Data / Florian Paul Breitwieser and Jacques Colinge -- Lipidomics, Mass Spectrometry, and Bioinformatics / Jürgen Hartler, Harald C. Köfeler, Christopher J. O. Baker, Ravi Tharakan and Gerhard G. Thallinger -- Protein Sequence-Structure-Function-Network Links Discovered with the ANNOTATOR Software Suite: Application to ELYS/Mel-28 / Georg Schneider, Westley Sherman, Durga Kuchibhatla, Hong Sain Ooi and Fernanda L. Sirota, et al. -- 3D Structure and Drug Design / Kristina Djinović-Carugo and Oliviero Carugo -- Integrating Biomolecular and Clinical Data for Cancer Research: Concepts and Challenges / Pornpimol Charoentong, Hubert Hackl, Bernhard Mlecnik, Gabriela Bindea and Jerome Galon, et al. -- Applied Data Mining: From Biomarker Discovery to Decision Support Systems / M. Osl, M. Netzer, S. Dreiseitl and C. Baumgartner -- Network-Based Methods for Computational Diagnostics by Means of R / Laurin A. J. Mueller, Matthias Dehmer and Frank Emmert-Streib.
- Computational neuroscience theoretical insights into brain function 2007ScienceDirect
- Computational systems biology. Second edition. [2nd ed.] 2014ScienceDirectIntroducing computational systems biology / Roland Eils, Andres Kriete -- Structural systems biology : modeling interactions and networks for systems studies / Robert B. Russell, Gordana Apic, Olga Kalinina, Leonardo Trabuco, Matthew J. Betts, Qianhao Lu -- Understanding principles of the dynamic biochemical networks of life through systems biology / Hans V. Westerhoff, Fei He, Ettore Murabito, Frederic Cremazy, Matteo Barberis -- Biological foundations of signal transduction, systems biology and aberrations in disease / Ursula Klingmuller, Marcel Schilling, Sofia Depner, Lorenza A. D'Alessandro -- Complexities in quantitative systems analysis of signaling networks / Christina Kiel, Luis Serrano -- Gene networks : estimation, modeling, and simulation / Seiya Imoto, Hiroshi Matsuno, Satoru Miyano -- Reconstruction of metabolic network from genome information and its structural and functional analysis / Hong-Wu Ma, An-Ping Zeng -- Standards, platforms, and applications / Stanley Gu, Herbert Sauro -- Databases, standards, and modeling platforms for systems biology / Juergen Eils, Elena Herzog, Baerbel Felder, Christian Lawerenz, Roland Eils -- Computational models for circadian rhythms : deterministic versus stochastic approaches / Jean-christophe Leloup, Didier Gonze, Albert Goldbeter -- Top-down dynamical modeling of molecular regulatory networks / Reinhard Laubenbacher, Pedro Mendes -- Discrete gene network models for understanding multicellularity and cell reprogramming : from network structure to attractor landscapes landscape / Joseph Xu Zhou, Xiaojie Qiu, Aymeric Fouquier D'Herouel, Sui Huang -- Stochastic simulations of cellular processes : from single cells to colonies / John Cole, Mike J. Hallock, Piyush Labhsetwar, Joseph R. Peterson, John E. Stone, Zaida Luthey-Schulten -- Advances in machine learning for processing and comparison of metagenomic data / Jean-Luc Bouchot, William L. Trimble, Gregory Ditzler, Yemin Lan, Steve Essinger, Gail Rosen -- Systems biology of infectious diseases and vaccines / Helder I. Nakaya -- From cell behavior to tissue deformation : computational modeling and simulation of early animal embryogenesis with the mecagen platform / Julien Delile, Ren Doursat, Nadine Peyriras -- Developing a systems biology of aging / Andres Kriete, Mathieu Cloutier -- Morphometric analysis of tissue heterogeneity in glioblastoma multiforme -- Applications in cancer research : mathematical models of apoptosis / Stefan M. Kallenberger, Stefan Legewie, Roland Eils.
- Computational systems neurobiology 2012SpringerFunctional Genomics and Molecular Networks Gene Expression Regulations in Complex Diseases: Down Syndrome as a Case Study / Marie-Claude Potier and Isabelle Rivals -- Reconstructing Models from Proteomics Data / Lysimachos Zografos, Andrew J. Pocklington and J. Douglas Armstrong -- Using Chemical Kinetics to Model Neuronal Signalling Pathways / Lukas Endler, Melanie I. Stefan, Stuart J. Edelstein and Nicolas Le Novère -- Breakdown of Mass-Action Laws in Biochemical Computation / Fidel Santamaria, Gabriela Antunes and Erik De Schutter -- Spatial Organization and Diffusion in Neuronal Signaling / Sherry-Ann Brown, Raquell M. Holmes and Leslie M. Loew -- The Performance (and Limits) of Simple Neuron Models: Generalizations of the Leaky Integrate-and-Fire Model / Richard Naud and Wulfram Gerstner -- Multi-compartmental Models of Neurons / Upinder S. Bhalla -- Noise in Neurons and Other Constraints / A. Aldo Faisal -- Methodological Issues in Modelling at Multiple Levels of Description / Kevin Gurney and Mark Humphries -- Virtues, Pitfalls, and Methodology of Neuronal Network Modeling and Simulations on Supercomputers / Anders Lansner and Markus Diesmann -- Co-operative Populations of Neurons: Mean Field Models of Mesoscopic Brain Activity / David T. J. Liley, Brett L. Foster and Ingo Bojak -- Cellular Spacing: Analysis and Modelling of Retinal Mosaics / Stephen J. Eglen -- Measuring and Modeling Morphology: How Dendrites Take Shape / Todd A. Gillette and Giorgio A. Ascoli -- Axonal Growth and Targeting / Duncan Mortimer, Hugh D. Simpson and Geoffrey J. Goodhill -- Encoding Neuronal Models in SBML / Sarah M. Keating and Nicolas Le Novère -- NeuroML / Padraig Gleeson, Volker Steuber, R. Angus Silver and Sharon Crook -- XPPAUT / Bard Ermentrout -- NEST by Example: An Introduction to the Neural Simulation Tool NEST / Marc-Oliver Gewaltig, Abigail Morrison and Hans Ekkehard Plesser.
- Computational toxicology methods and applications for risk assessment 2013ScienceDirectComputational Toxicology: Methods and Applications for Risk Assessment is an essential reference on the translation of computational toxicology data into information that can be used for more informed risk assessment decision-making. This book is authored by leading international investigators who have real-world experience in relating computational toxicology methods to risk assessment. Key topics of interest include QSAR modeling, chemical mixtures, applications to metabolomic and metabonomic data sets, toxicogenomic analyses, applications to REACH informational strategies and much more. With a free companion website featuring an image bank from the book and web links for further research and reading, this authoritative reference is your complete guide to computational toxicology methods and applications to risk assessment. Authored by leading international researchers engaged in cutting-edge applications of computational methods for translating complex toxicological data sets into useful risk assessment information. Incorporates real-world examples of how computational toxicological methods have been applied to advance the science of risk assessment Provides the framework necessary for new technologies and fosters common vocabularies and principles upon which the effects of new chemical entities should be compared.
- Computational vision and medical image processing Vipimage 2011 : proceedings of VIPIMAGE 2011, Third ECCOMAS Thematic Conference on Computational Vision and Medical Image Processing, Olhão, Algarve, Portugal, 12-14 October 2011 2012CRCnetBASE
- Consumer health informatics / Deborah Lewis, Betty L. Chang, Charles P. Friedman -- Empowered consumers / Patricia Flatley Brennan and Charles Safran -- Tailored health communication / Rita Kukafka -- Design and evaluation of consumer health information web sites / Gunther Eysenbach -- Information delivery methods / James H. Harrison, Jr. -- Delivery of online learning for healthcare consumers / Deborah Lewis -- Qualitative evaluation in consumer health informatics / Bonnie Kaplan -- Patient-to-patient communication: support groups and virtual communities / Gunther Eysenbach -- Electronic patient-centered communication: e-mail and other e-ways to communicate clinically / Daniel Z. Sands -- Consumer health vocabulary / Catherine Arnott Smith and P. Zoë Stavri -- Disability informatics / Richard Appleyard -- Ethical issues in consumer health informatics / Holly B. Jimison -- Social informatics and consumer health / Steve Sawyer -- Security of healthcare information systems / Roy Schoenberg -- The National Library of Medicine reaches out to consumers / Joyce E.B. Backus and Eve-Marie Lacroix -- Baby CareLink: collaborative tools to support families / Charles Safran and Denise Goldsmith -- CHOICEs: patients as participants in shared care planning at the point of care / Cornelia M. Ruland -- MedCERTAIN/MedCIRCLE: using semantic web technologies for quality management of health information on the web / Gunther Eysenbach -- The MI-HEART Project / Rita Kukafka, Yves A. Lussier, and James J. Cimino -- CHESS: 10 years of research and development in consumer health informatics for broad populations, including the underserved / David H. Gustafson ... [et al.].
- Part I. Introducing the Domain and Levels of Service -- 1. Character of domain and organization of book -- 2. Economy 1: immanent mismatch between demand and supply of health care workforce -- 3. Level 0: searching-finding-trusting-acting-risking one's life? -- 4. Level 1: enhancing the provider- client relation through IT -- 5. Level 2: services without in-person contact between provider and client -- 6. Level 3: patient power on the web: the multifaceted role of personal health wisdom -- 7. Distinctive features of services conveyed through mobile apps -- Part II. Building Safety Nets Around the Active Client -- 8. Dimensions of patient risks and requirements for patient safety -- 9. Services for all stages of the metabolic syndrome and its consequences -- 10. Basic services reach out towards under-served populations -- 11. Smart homes: empowering the patient till the end -- 12. Partial solutions for patient safety -- Part III. Additional Methodology -- 13. Privacy and data protection: mission impossible? -- 14. The patient-centered electronic health record and patient portals -- 15. Scrutinized proof of effectiveness or cost effectiveness regarding patient reported outcomes -- 16. Economy 2: economic subsistence of services when research funding ends -- 17. Towards future consumer health informatics adapted health care legislation -- Trademarks -- Nomenclature -- General index -- Index of services.
- Creative destruction of medicine how the digital revolution will create better health care 2012ProQuest Safari"Mobile technology has transformed our lives, and personal genomics is revolutionizing biology. But despite the availability of technologies that can provide wireless, personalized health care at lower cost, the medical community has resisted change. In The Creative Destruction of Medicine, Eric Topol--one of the nation's top physicians--calls for consumer activism to demand innovation and the democratization of medical care." -- [Publisher-provided data]
- Section I. Innovation and process considerations in the role of IS/IT in e-health. -- 1. Improving e-performance management in healthcare using intelligent IT solutions / Fatemeh Hoda Moghimi and Nilmini Wickramasinghe -- 2. An intelligence e-risk detection model to improve decision efficiency in the context of the orthopaedic operating room / Fatemeh Hoda Mogihim, Hossein Zadeh, and Nilmini Wickramasinghe -- 3. Healthcare information systems design : using a strategic improvisation model / Say Yen Teoh and Nilmini Wickramasinghe -- 4. Assimilation of healthcare information systems (HIS) : an analysis and critique / Hidayah Sulaiman and Nilmini Wichramasinghe -- 5. e-health in China : an evaluation / Yu Yun ... [et al.] -- 6. Improving the process of healthcare delivery in an outpatient environment : the case of a urology department / Chris Gonzalez and Nilmini Wickramasinghe -- 7. Adaptations for e-kiosk systems in Germany to develop barrier-free terminals for handicapped persons / Manuel Zwicker, Juergen Seitz, and Nilmini Wichramasinghe -- Section II. Design and organisation designing supportive and collaborative electronic health environments. -- 8. Collaborative approach for sustainable citizen-centered health care / Pirkko Nykänen and Antto Seppäla ̈-- 9. Strategies and solutions in e-health : a literature review / Marco De Marco, Francesca Ricciardi, and Jan vom Brocke -- 10. Online discussion forum as a means of peer support / R. Halonen -- 11. Designing persuasive health behavior change interventions / Tuomas Lehto -- 12. Accessiblility in the web for disabled people / Irene Krebs, Arnim Nethe, and Reetta Raitoharju -- Section III. The importance of people in e-health : lest we forget. -- 13. Knowledge management : often neglected but crucial to ehealth / Juerg P. Bleuer ... [et al.] -- 14. Patient Empowerment : a two way road / Lodewijk Bos -- 15. Citizen empowerment / Amir Hannan -- 16. E-health : focusing on people-centric dimensions / Rajeev K. Bali ... [et al.] -- 17. A model of estimating the direct benefits of implementing electronic data exchange of EMRs and state immunization information systems / Michael L. Popovich and Xiaohui Zhang -- Section IV. Innovation in e-health. -- 18. Business models for electronic healthcare services in Germany / S. Duennebeil, J. Leimeister, and H. Krcmar -- 19. Smart objects in healthcare : impact on clinical logistics / Martin Sedlmayr and Ulli Münch -- 20. Agency theory in e-healthcare and telemedicine : a literature study / Joerg Leukel ... [et al.] -- 21. Cost accounting and decision support for healthcare institutions / L. Waehlert, A. Wagner, and H. Czap -- 22. A comprehensive approach to the IT : clinial practice interface / David Zakim and Mark Dominik Alscher
- Data mining practical machine learning tools and techniques.. 3rd ed. / 2011ScienceDirectPart I. Machine Learning Tools and Techniques: -- 1. What's it all about? -- 2. Input: concepts, instances, and attributes -- 3. Output: knowledge representation -- 4. Algorithms: the basic methods -- 5. Credibility: evaluating what's been learned -- Part II. Advanced Data Mining: -- 6. Implementations: real machine learning schemes -- 7. Data transformation -- 8. Ensemble learning -- 9. Moving on: applications and beyond -- Part III. The Weka Data Mining Workbench: -- 10. Introduction to Weka -- 11. The explorer -- 12. The knowledge flow interface -- 13. The experimenter -- 14 The command-line interface -- 15. Embedded machine learning -- 16. Writing new learning schemes -- 17. Tutorial exercises for the Weka explorer.
- Deep sequencing data analysis 2013Springer ProtocolsIntroduction to high-throughput sequencing experiments : design and bioinformatics analysis / Rachelly Normand and Itai Yanai -- Compressing resequencing data with GReEn / Armando J. Pinho, Diogo Pratas, and Sara P. Garcia -- On the accuracy of short read mapping / Peter Menzel ... [et al.] -- Statistical modeling of coverage in high-throughput data / David Golan and Saharon Rosset -- Assembly algorithms for deep sequencing data : basics and pitfalls / Nitzan Kol and Noam Shomron -- Short read mapping for exome sequencing / Xueya Zhou ... [et al.] -- Profiling short tandem repeats from short reads / Melissa Gymrek and Yaniv Erlich -- Exome sequencing analysis : a guide to disease variant detection / Ofer Isakov, Marie Perrone, and Noam Shomron -- Identifying RNA editing sites in miRNAs by deep sequencing / Shahar Alon and Eli Eisenberg -- Identifying differential alternative splicing events from RNA sequencing data using RNASeq-MATS / Juw Won Park ... [et al.] -- Optimizing detection of transcription factor-binding sites in ChIP-seq experiments / Aleksi Kallio and Laura L. Elo -- Statistical analysis of ChIP-seq data with MOSAiCS / Guannan Sun ... [et al.] -- Detection of reverse transcriptase termination sites using cDNA ligation and massive parallel sequencing / Lukasz J. Kielpinski ... [et al.].
- Designing user studies in informatics 2011SpringerPart I Designing the User Study -- Overview -- Variables -- Design equation and statistics -- Between-subjects design -- Within-subject designs -- Advanced designs -- Part II Practical Tips -- Understanding main and interaction effects -- Conducting multiple comparisons -- Gold standard and user evaluations -- Recruiting and motivating study participants -- Institutional review board (IRB) approval -- Resources -- Part III Common Mistakes to Avoid -- Avoid bias -- Avoid missing the effect -- Avoid missing variables or conditions -- Other errors to avoid -- Appendix: cookbook for designing user studies in informatics.
- Digital communication in medical practice 2009Springer
- Print MaterialFor the past few decades, technology has been touted as the cure for all of healthcare's ills, yet medicine stubbornly resisted computerization-- until now. Thanks largely to billions of dollars in federal incentives, healthcare has finally gone digital. Wachter examines healthcare at the dawn of its computer age, and shows how technology is changing care at the bedside. He questions whether government intervention has been useful or destructive-- and does so with clarity, insight, humor, and compassion.
- Digital image quality in medicine 2014SpringerMaking a good diagnostic image is only the beginning; keeping it good and diagnostically sound is a much more difficult proposition, one that is often neglected or forgotten by clinical practitioners. With anything digital, the assumption of persistent original quality opens a Pandora's box of medical fiascos. Poorly selected image interpolation, thoughtlessly used compression, confused image enhancement options and the like can transform a good original into a useless clutter of pixels. This book is dedicated to learning better options.
- Digital imaging and communications in medicine (DICOM) a practical introduction and survival guide. 2nd ed. 2012SpringerPart I. Introduction to DICOM -- 1. What Is DICOM? -- 2. How does DICOM work? 3. Where do you get DICOM from? -- Part II. DICOM and clinical data -- 4. A brief history of DICOM -- 5. Parlez-vous DICOM? 6. Medical images in DICOM -- Part III. DICOM comunications -- 7. DICOM SOPs: Basic 8. DICOM SOPs: Beyond basic -- 9. DICOM associations -- Part IV: DICOM media and security -- 10. DICOM media: files, folders, and DICOMDIRs -- 11. DICOM security -- 12. Incompatibility of compatible -- Part V. Advanced topics -- 13. DICOM and teleradiology -- 14. Standards and system integration in digital medicine -- 15. Disaster PACS planning and management -- 16. DICOM applications: usual and not -- 17. DICOM software development -- 18. DICOM implementation plans -- 19. DICOM FAQs.
- eHealth solutions for healthcare disparities 2008SpringerAn overview of healthcare disparities -- Provider factors in healthcare disparities -- Patient factors in healthcare disparities -- Healthcare system factors in healthcare disparities -- The social "nonmedical" determinants of health -- The role of the Internet in American life -- The iHealth revolution -- Digital disparities -- The role of eHealth in patient engagement and quality improvement -- Medical informatics -- Public health informatics -- Beyond traditional paradigms in disparities research -- Health information technology policy perspectives and healthcare disparities -- Disparities and eHealth: achieving the promise and the potential.
- eHealth, care and quality of life 2014SpringerThe debate over eHealth is alive as never before. Supporters suggest that it will result in dramatic innovations in healthcare, including a giant leap towards patient-centered care, new opportunities to improve effectiveness, and enhanced wellness and quality of life. In addition, the growing market value of investments in health IT suggests that eHealth can offer at least a partial cure for the current economic stagnation. Detractors counter these arguments by claiming that eHealth has already failed: the UK Department of Health has shut down the NHS National Program for IT, Google has discontinued its Health flagship, and doubts have arisen over privacy safeguards for both patients and medical professionals. This book briefly explains why caregivers, professionals, technicians, patients, politicians, and others should all consider themselves stakeholders in eHealth. It offers myth-busting responses to some ill-considered arguments from both sides of the trench, in the process allowing a fresh look at eHealth. In addition, it describes how the technical failures of previous eHealth systems can be avoided, examines the legal basis of eHealth, and discusses associated ethical issues.
- Part 1. Introduction -- part 2. Identifying and preventing EHR safety concerns -- part 3. EHR users and usability -- part 4. Clinical decision support -- part 5. Referrals -- part 6. Laboratory test result management -- part 7. Bar coded medication administration -- part 8. Computer-based provider order entry.
- Electronic healthcare information security 2010SpringerIntroduction to e-Healthcare Information Security / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Securing e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Laws and Standards for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Secure e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Comprehensive Framework for Secure e-Healthcare Information / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Towards a Unified Security Evaluation Framework for e-Healthcare Information Systems / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi -- Discussions / Charles A. Shoniregun, Kudakwashe Dube and Fredrick Mtenzi.
- v. 1. A-L -- v. 2. M-Z.
- Encyclopedia of information systems 2003ScienceDirect
- Overview: theoretical perspectives and methodologies for the evaluation of healthcare information systems -- Qualitative research methods for evaluating computer information systems -- Multiple perspectives: evaluating healthcare information systems in collaborative environments -- Survey methods for assessing social impacts of computers in healthcare organizations -- Using the Internet for surveys and research -- Cognitive approaches to the evaluation of healthcare information systems -- Work-sampling: a statistical approach to evaluation of the effect of computers on work patterns in health care -- Evaluation of health informatics: social network analysis -- Evaluation in health informatics: computer simulation -- Computers in the consulting room: a case study of clinician and patient perspectives -- Introducing physician order entry at a major academic medical center, A: Impact on organizational culture and behavior, B: Impact on medical education -- Evaluating the capability of information technology to prevent adverse drug events: a computer simulation approach -- Implementing computers in ambulatory care: implications of physician practice patterns for system design -- Nursing documentation time during implementation of an electronic medical record -- Computer charting: an evaluation of a respiratory care computer system -- Research and evaluation: future directions.
- Challenges of Evaluation in Biomedical Informatics, p. 1-20 -- Evaluation as a Field, p. 21-47 -- Determining What to Study, p. 48-84 -- The Structure of Objectivist Studies, p. 85-112 -- Measurement Fundamentals, p. 113-144 -- Developing and Improving Measurement Methods, p. 145-187 -- The Design of Demonstration Studies, p. 188-223 -- Analyzing the Results of Demonstration Studies, p. 224-247 -- Subjectivist Approaches to Evaluation, p. 248-266 -- Performing Subjectivist Studies in the Qualitative Traditions Responsive to Users / Joan Ash, Allen Smith and P. Starvi, p. 267-300 -- Economic Aspects of Evaluation / Mark Roberts, p. 301-337 -- Proposing and Communicating the Results of Evaluation Studies: Ethical, Legal, and Regulatory Issues, p. 338-361.
- Factors affecting physician professional satisfaction and their implications for patient care, health systems, and health policy 2013RAND HealthOne of the American Medical Association's core strategic objectives is to advance health care delivery and payment models that enable high-quality, affordable care and restore and preserve physician satisfaction. Such changes could yield a more sustainable and effective health care system with highly motivated physicians. To that end, the AMA asked RAND Health to characterize the factors that lead to physician satisfaction. RAND sought to identify high-priority determinants of professional satisfaction that can be targeted within a variety of practice types, especially as smaller and independent practices are purchased by or become affiliated with hospitals and larger delivery systems. Researchers gathered data from 30 physician practices in six states, using a combination of surveys and semistructured interviews. This report presents the results of the subsequent analysis, addressing such areas as physicians' perceptions of the quality of care, use of electronic health records, autonomy, practice leadership, and work quantity and pace. Among other things, the researchers found that physicians who perceived themselves or their practices as providing high-quality care reported better professional satisfaction. Physicians, especially those in primary care, were frustrated when demands for greater quantity of care limited the time they could spend with each patient, detracting from the quality of care in some cases. Electronic health records were a source of both promise and frustration, with major concerns about interoperability between systems and with the amount of physician time involved in data entry.
- Fractals in biology and medicine. Volume IV 2005Springer
- Functional informatics in drug discovery 2008CRCnetBASEIntelligent automation / James M. Dixon -- Neurally inspired algorithms as computational tools / Mark Flynn and Garrett T. Kenyon -- Using pharmacodynamic biomarkers to accelerate early clinical drug development / Ole Vesterqvist -- Opportunities in CNS drug discovery and development / Albert Pinhasov ... [et al.] -- Clinical success of antibody therapeutics in oncology / Bernard J. Scallon ... [et al.] -- Relating target sequence to biological function / Greg M. Arndt -- Use of protein microarrays for molecular network analysis and signal-pathway profiling / Katherine R. Calvo, Lance A. Liotta, and Emanuel F. Petricoin -- Laser-microdissection-based transcriptomics using microarrays / Fredrik Kamme ... [et al.].
- "Foreword Personal health information comprises the most sensitive and intimate details of one's life, such as those relating to one's physical or mental health, and the health history of one's family. Intuitively, we understand the importance of protecting health information in order to ensure the confidentiality of such personal data and the privacy of the individual to whom it relates. Personal health information must also be accurate, complete, and accessible to health care practitioners in order to provide individuals with necessary health care. At a broader level, for secondary uses that go beyond the treatment of the individual, health-related data are needed for the benefit of society as a whole. These vitally important secondary uses include activities to improve the quality of care, health research, and the management of publicly funded health care systems. As the information and privacy commissioner of Ontario, Canada, my role includes the oversight of health privacy legislation governing the collection, use, and disclosure of personal health information by organizations and individuals involved in the delivery of health care services. Ontario's Personal Health Information Protection Act (PHIPA) aims to respect an individual's right to privacy in relationship to his or her own personal health information while accommodating the legitimate need to access health information for well-defined purposes. PHIPA does this in part by establishing clear rules for the use and disclosure of personal health information for secondary purposes. The object of these rules is to maximize the benefits of both respecting personal privacy and making health information accessible for purposes that serve society as a whole"--Provided by publisher.
- Handbook of bioinspired algorithms and applications 2006CRCnetBASE
- Handbook of chemoinformatics algorithms 2010CRCnetBASEChapter 1. Representing Two-Dimensional (2D) Chemical Structures with Molecular Graphs / Ovidiu Ivanciuc -- Chapter 2. Algorithms to Store and Retrieve Two-Dimensional (2D) Chemical Structures / Milind Misra, Jean-Loup Faulon -- Chapter 3. Three-Dimensional (3D) Molecular Representations / Egon L. Willighagen -- Chapter 4. Molecular Descriptors / Nikolas Fechner, Georg Hinselmann, Jor̈g Kurt Wegner -- Chapter 5. Ligand- and Structure-Based Virtual Screening / Robert D. Clark, Diana C. Roe -- Chapter 6. Predictive Quantitative Structure-Activity Relationships Modeling: Data Preparation and the General Modeling Workflow / Alexander Tropsha, Alexander Golbraikh -- Chapter 7. Predictive Quantitative Structure-Activity Relationships Modeling: Development and Validation of QSAR Models / Alexander Tropsha, Alexander Golbraikh -- Chapter 8. Structure Enumeration and Sampling / Markus Meringer -- Chapter 9. Computer-Aided Molecular Design / Donald P. "Visco, Jr." -- Chapter 10. Computer-Aided Molecular Design / Diana C. Roe -- Chapter 11. Reaction Network Generation / Jean-Loup Faulon, Pablo Carbonell -- Chapter 12. Open Source Chemoinformatics Software and Database Technologies / Rajarshi Guha -- Chapter 13. Sequence Alignment Algorithms / Tatsuya Akutsu -- Chapter 14. Machine Learning-Based Bioinformatics Algorithms / Shawn Martin -- Chapter 15. Using Systems Biology Techniques to Determine Metabolic Fluxes and Metabolite Pool Sizes / Fangping Mu, Amy L. Bauer, James R. Faeder, William S. Hlavacek.
- Handbook of computational molecular biology 2006CRCnetBASE
- Handbook of evaluation methods for health informatics 2006ScienceDirectConceptual apparatus -- Types of user assessments of IT-based solutions -- Choosing or constructing methods -- Overview of assessment methods -- Descriptions of methods and techniques -- Other useful information -- Methodological and methodical perils and pitfalls at assessment, background information -- Approach to identification of pitfalls and perils -- Framework for meta-assessment of assessment studies.
- Health care information systems a practical approach for health care management. Third edition. [3rd ed.] 2013ebrary"The revised third edition of Health Care Information Systems is a comprehensive text that offers an understanding of health care information systems that helps readers work effectively with and support information systems design, as well as the development and implementation. It covers current and developing information systems of interest to managers in health services organizations; health care information systems architecture; security and privacy issues; uses of health care information for clinical and strategic analysis and decision support; techniques for developing and evaluating an information system request for proposal; and information on the future"--Provided by publisher.
- Healthcare informatics improving efficiency and productivity 2010CRCnetBASEAn introduction to the US health care industry, information technology, and informatics / by Stephan Kudyba, Richard Temple -- "Quality time" in healthcare : strategies for achieving national goals for meaningful use of health information technology / by Michael H. Zaroukian, Peter Basch -- A project management framework for healthcare informatics initiatives / by Christi Rushnell, Mary Beattie -- Nursing roles in the implementation of clinical information systems / by Terry Moore -- Architecting computerized physician order entry (CPOE) for optimal utilization / by James F. Keel III, D. Arlo Jennings -- Knowledge translation and informatics in healthcare / by Ann McKibbon -- Self service technology in healthcare / by Tomas Gregorio -- The world of health analytics / by Jason Burke -- Enhancing data resources and business intelligence in healthcare / by Stephan Kudyba, Mark Rader -- Application of healthcare informatics to improving patient safety and outcomes : learning from the experiences of Trinity Health / by Rajiv Kohli ... [et al.] -- Data mining in health care / by Wullianallur Raghupathi -- Using data mining to build alerting systems for decision support in healthcare / by Billie Anderson, Cali M. Davis, J. Michael Hardin -- Data mining techniques to enhance health care cost savings through the identification of abusive billing practices and the optimization of care enhancement services / by Theodore L. Perry ... [et al.].
- Healthcare information systems. 2nd ed. 2003CRCnetBASE
- The Evolution of Healthcare Infrastructure -- History of Health Determinants -- Public Health Success When Simple -- Public Health Failure When Complex -- Medicine Success When Simple -- Medicine Failure When Complex -- Medical Records for Health Systems -- Health Determinants for Individuals and Populations -- Measurement of Individual Activity (Explicit Text) -- Sensors for Individual Ability (Implicit Data) -- Genomes for Individual Ability (Features) -- Networks for Population Function (Persons) -- Mobile Monitors for Health Systems -- The Future of Healthcare Infrastructure.
- High-dimensional single cell analysis mass cytometry, multi-parametric flow cytometry and bioinformatic techniques 2014SpringerThis volume highlights the most interesting biomedical and clinical applications of high-dimensional flow and mass cytometry. It reviews current practical approaches used to perform high-dimensional experiments and addresses key bioinformatic techniques for the analysis of data sets involving dozens of parameters in millions of single cells. Topics include single cell cancer biology; studies of the human immunome; exploration of immunological cell types such as CD8+ T cells; decipherment of signaling processes of cancer; mass-tag cellular barcoding; analysis of protein interactions by proximity ligation assays; Cytobank, a platform for the analysis of cytometry data; computational analysis of high-dimensional flow cytometric data; computational deconvolution approaches for the description of intracellular signaling dynamics; and hyperspectral cytometry. All 10 chapters of this book have been written by respected experts in their fields. It is an invaluable reference book for both basic and clinical researchers.
- ch. 1. Introduction, p. 1-12 -- ch. 2. Background, p. 13-38 -- ch. 3. Models of Linear Systems, p. 39-56 -- ch. 4. Models of Nonlinear Systems, p. 57-101 -- ch. 5. Identification of Linear Systems, p. 103-123 -- ch. 6. Correlation-Based Methods, p. 125-167 -- ch. 7. Explicit Least-Squares Methods, p. 169-206 -- ch. 8. Iterative Least-Squares Methods, p. 207-250.
- E-health is closely related with networks and telecommunications when dealing with applications of collecting or transferring medical data from distant locations for performing remote medical collaborations and diagnosis. In this book we provide an overview of the fields of image and signal processing for networked and distributed e-health applications and their supporting technologies. The book is structured in 10 chapters, starting the discussion from the lower end, that of acquisition and processing of biosignals and medical images and ending in complex virtual reality systems and techniques providing more intuitive interaction in a networked medical environment. The book also discusses networked clinical decision support systems and corresponding medical standards, WWW-based applications, medical collaborative platforms, wireless networking, and the concepts of ambient intelligence and pervasive computing in electronic healthcare systems.
- Immunoinformatics 2008SpringerIMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
- Immunoinformatics predicting immunogenicity in silico 2007Springer Protocols
- 2013 ebraryHIPAA : stakeholder impacts and effects of provisions of the HITECH Act -- Organizational culture : what is needed to adopt HIT across different types of hospitals? -- Health economics : organizational finance and healthcare IT -- Cost benefit analysis and funding EMRs -- Analyzing the presence of EMRs across different health providers -- EMR impacts on quality of care and cost to the patient -- The physician and perceptions : medical malpractice and impacts from HIT usage -- Reduction in bioterrorism through the usage of EMRs -- The direction of health informatics and the future : the E-health industry.
- Implementing an electronic health record system 2005SpringerOrganizational climate -- Needs assessment -- Vendor selection and contract negotiation -- Infrastructure -- Workflow assessment and redesign -- Staffing and managing implementation teams -- Usability -- Training -- Clinical decision support -- Translating scope of practice into effective EHR workflows -- System integration -- Production support -- Managing the client-vendor partnership -- Phased implementation -- Optimizing primary-care practices -- Special-purpose software -- Optimizing inpatient care -- Extending EHR access to patients -- Extending EHR access to external physicians -- Summary and prospects.
- Informatics education in healthcare lessons learned 2014SpringerThis book reviews and defines the current state of the art for informatics education in medicine and health care. This field has undergone considerable change as the field of informatics itself has evolved. Twenty years ago almost the only individuals involved in health care who had even heard the term "informatics" were those who identified themselves as medical or nursing informaticians. Today, we have a variety of subfields of informatics including not just medical and nursing informatics, but informatics applied to specific health professions (such as dental or pharmacy informatics), as well as biomedical informatics, bioinformatics and public health informatics. Informatics Education in Health Care addresses the broad range of informatics education programs available today. The Editor and very experienced internationally recognized informatics educators who have contributed to this work have made the tacit knowledge explicit and shared some of the lessons they have learned. This book therefore represents the key reference for all involved in the informatics education whether they be trainers or trainees.
- Informatics in medical imaging 2012CRCnetBASEOntologies in the radiology department / Dirk Marwede -- Informatics constructs / Steve G. Langer -- Health level 7 imaging integration / Helmut König -- DICOM / Steven C. Horii -- Integrating the healthcare enterprise IHE / Steve G. Langer -- Operating systems / Christos Alexakos and George C. Kagadis -- Networks and networking / Christos Alexakos and George C. Kagadis -- Storage and image compression / Craig Morioka, Frank Meng, and Ioannis Sechopoulos -- Displays / Elizabeth A. Krupinski -- Digital X-ray acquisition technologies / John Yorkston and Randy Luhta -- Efficient database designing / John Drakos -- Web-delivered interactive applications / John Drakos -- Principles of three-dimensional imaging from cone-beam projection data / Frédéric Noo -- Multimodality imaging / Katia Passera, Anna Caroli, and Luca Antiga -- Computer-aided detection and diagnosis / Lioner T. Cheng, Daniel J. Blezek, and Brad J. Erickson -- Picture archiving and communication systems -- Brent K. Stewart -- Hospital information systems, radiology information systems, and electronic medical records / Herman Oosterwijk -- Procurement / Boris Zavalkovskiy -- Operational issues / Shawn Kinzel ... [et al.] -- Teleradiology / Dimitris Karnabatidis and Konstantinos Katsanos -- Ethics in the radiology department / William R. Hendee -- Imaging informatics beyond radiology / Konstantinos Katsanos ... [et al.] -- Informatics in radiation oncology / George Starkschall and Peter Balter.
- Informatics in radiation oncology 2014CRCnetBASE"A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
- Information and communication technologies in healthcare 2011CRCnetBASECh. 1. Healthcare systems : Introduction / Frank M. Groom -- Ch. 2. Technology as a catalyst for health enhancement / Jane Ellery and Peter J. Ellery -- Ch. 3. Health information exchange / Dave Yoder -- Ch. 4. Universal data standards / Colleen Willis -- Ch. 5. Healthcare information exchange / Kent Supancik -- Ch. 6. Health information technology in the United States : achieving legal and regulatory results that enhance innovation and adoption / Stuart N. Brotman, Gabriel G. Brotman and Jennifer E. Paul -- Ch. 7. Healthcare regulations, privacy, security, and information age considerations / Sydney Morris -- Ch. 8. Usability : patient-physician interactions and the electronic medical record / Carolyn K. Shue and Laura L.S. O'Hara -- Ch. 9. Remembering human factors when implementing technology use : a case study in home healthcare usability / Lori A. Byers -- Ch. 10. Security and privacy : impacts of evolving technologies and legislation / Robert Faix, Chad Cagnolatti, and David Flynn -- Ch. 11. New facility planning : a healthcare focus / Todd Hollowell and Carl Fleming -- Ch. 12. Developing innovative health information for youth : communication theory for practical emerging media applications / Lou Ann Stroup, Chelsey Sigler, and Jay E. Gillette -- Ch. 13. Re-envisioning the IndianaMedicaid.com website as a member-focused portal : a case study on usability and technology for transforming healthcare communication / Jared B. Linder -- Appendix: Glossary of health care terms from IBM.
- Information discovery on electronic health records 2010CRCnetBASEOverview of XML / Fernando Farfan, Vagelis Hristidis -- Electronic health records / Fernando Farfan, Ramakrishna Varadarajan, and Vagelis Hristidis -- Overview of information discovery techniques on EHRs / Vagelis Hristidis -- Data Quality and integration issues in electronic health records / Ricardo Joao Cruz-Correia ... [et al.] -- Ethical, legal, and social issues for EHR data protection / Reid Cushman -- Searching electronic health records / Ramakrishna Varadarajan ... [et al.] -- Data mining and knowledge discovery on EHRs / Donald J. Berndt, Monica Chiarini Tremblay, and Stephen L. Luther -- Privacy-preserving information discovery on EHRs / Li Xiong ... [et al.] -- Real-time and mobile physiological data analysis / Daniele Apiletti ... [et al.] -- Medical image segmentation / Xiaolei Huang and Gavriil Tschpenakis.
- pt. 1. Overview -- pt. 2. Clinical practice issues -- pt. 3. Patient and client centric technologies section -- pt. 4. Organizational issues.
- Information technology framework for predictive, preventive and personalised medicine a use-case with hepatocellular carcinoma 2015SpringerPreface -- Introduction -- The Digital Patient Model and Model Guided Therapy -- Hepatocellular Carcinoma and Patient Assessment -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- Imaging in Hepatocellular Carcinoma: PET/CT -- Personalized Chemotherapy for Hepatocellular Carcinoma -- Surgical Treatment for Hepatocellular Carcinoma.- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- Chapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- Minimally Invasive Therapies for Hepatocellular Cancer:Catheter-Directed Therapies -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- Design of an IT System for Hepatocellular Carcinoma -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.
- Over the last 30-40 years, information technology (IT) has revolutionized professional life for millions of people around the world. IT has reduced the need for bulk storage of paper records by organizations, has enabled automation of tasks that were previously repetitive and labor-intensive, and carry them out in a fast and accurate way, has enabled economies of scale, improved efficiencies and enabled new ways of working that were hitherto impossible. In parallel with the rise of IT during the last 40 years, the role of the pharmacist - and the society in which pharmacists work - has changed considerably. Pharmacists are no longer principally compounders of medicines, but they are still responsible for ensuring that the patient receives the correct medicine, ensuring that the patient understands why they should take their medicine, and helping the patient with taking the medicine and being concordant with therapy.Information Technology in Pharmacy: an Integrated Approach provides a concise and practical general introduction to pharmacy IT, discusses issues surrounding the adoption of technology and how technologies may be utlilized by the pharmacy profession to exercise new professional roles and achieve new professional aspirations. This book will be of prime interest to practicing pharmacists at all levels, pharmacy students and pharmacy educators, but also to health informaticians, hospital and health care system administrators.
- Information technology solutions for healthcare 2006Springer
- The healing edge / Lyle Berkowitz and Chris McCarthy -- Mad for method / Chris McCarthy and Christi Dining Zuber -- section 1. You have an EHR: now what?!!?!. The inflection navigator / Lyle Berkowitz -- Making "right" easier / Peter Basch -- Prevention every time / James L. Holly -- Logic rules! / John W. Trudel and Lloyd D. Fisher -- "All or none" bundle philosophy / Thomas R. Graf -- Automatically getting better / David C. Stockwell and Brian R. Jacobs -- section 2. Meet you at 01100101. The connected patient / Jonathan S. Wald -- The virtual consult / Erin DeMarce Leff ... [et al.] -- TeleVisit keeps IT local / Ajay Sood ... [et al.] -- Mommy monitor / Steve Huffman and April R. Daugherty -- Every language now / David D. O'Neill, Susan Anthony, and Margaret Laws -- Rise of the ePharmacists / Mark S. Gagnon and Janell Moerer -- section 3. On the edge of edge. The smartest room / Tamra E. Minnier and David T. Sharbaugh -- One EMR to go please / Steve Flammini and James W. Noga -- Real-time, right care / Debra J. Hurd and Brian D. Patty -- Dashboards 2.0 / George Reynolds -- The patient voice amplified / Valerie M. Sue and Karen Tsang -- The gaming edge / Alex Tam, Vivian Distler, and Bradley Kreit.
- Rationale and Need to Articulate Medical and Dental Data / Valerie J.H. Powell, Franklin M. Din -- HIT Considerations: Informatics and Technology Needs and Considerations / Miguel Humberto Torres-Urquidy -- Metrics and Measurements / Valerie J.H. Powell, Amit Acharya -- Broader Considerations of Medical and Dental Data Integration / Stephen Foreman, Joseph Kilsdonk -- International Perspectives / Miguel Humberto Torres-Urquidy -- An Integrated Medical-Dental Electronic Health Record Environment: A Marshfield Experience / Amit Acharya, Natalie Yoder, Greg Nycz -- Conclusion and Recommendations / Franklin M. Din, Valerie J.H. Powell.
- Intelligent and adaptive systems in medicine 2008CRCnetBASE
- Computerization of clinical guidelines : an application of medical document processing / Gersende Georg -- Case-based medical informatics / Stefan V. Pantazi, José F. Arocha and Jochen R. Moehr -- Analysis and architecture of clinical workflow systems using agent-oriented lifecycle models / James P. Davis and Raphael Blanco -- Virtual communities in health care / George Demiris -- Evidence based telemedicine / George Anogianakis ... [et al.] -- Current status of computerized decision support systems in mammography / G.D. Tourassi -- Medical diagnosis and prognosis based on the DNA microarray technology / Y. Fukuoka, H. Inaoka and I.S. Kohane -- Wearable devices in healthcare / Constantine Glaros and Dimitrios I. Fotiadis.
- Internet cool tools for physicians 2009Springer
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