Books by Subject
- 2007 Springer ProtocolsFlower, Darren R.
- 2013 ebrary2013 CRCnetBASESrinivasan, Divya.HIPAA : stakeholder impacts and effects of provisions of the HITECH Act -- Organizational culture : what is needed to adopt HIT across different types of hospitals? -- Health economics : organizational finance and healthcare IT -- Cost benefit analysis and funding EMRs -- Analyzing the presence of EMRs across different health providers -- EMR impacts on quality of care and cost to the patient -- The physician and perceptions : medical malpractice and impacts from HIT usage -- Reduction in bioterrorism through the usage of EMRs -- The direction of health informatics and the future : the E-health industry.
- 2005 SpringerBieber, Eric J.; Richards, Frank; Walker, James M.Organizational climate -- Needs assessment -- Vendor selection and contract negotiation -- Infrastructure -- Workflow assessment and redesign -- Staffing and managing implementation teams -- Usability -- Training -- Clinical decision support -- Translating scope of practice into effective EHR workflows -- System integration -- Production support -- Managing the client-vendor partnership -- Phased implementation -- Optimizing primary-care practices -- Special-purpose software -- Optimizing inpatient care -- Extending EHR access to patients -- Extending EHR access to external physicians -- Summary and prospects.
- 2012Osheroff, Jerome A.
- 2007 SpringerFlower, Darren R.; Timmis, Jonathan.
- 2010 SpringerSintchenko, Vitali.Informatics for infectious disease research and control -- Bioinformatics of microbial sequences -- Mining databases for microbial gene sequences -- Comparative genomics of pathogens -- Systems microbiology: gaining insights in transcriptional networks -- Host-pathogen systems biology -- Text mining for discovery of host-pathogen interactions -- Network approach to understanding pathogen population structure -- Computational epitope mapping -- Pangenomic reverse vaccinology -- Immunoinformatics: the next step in vaccine design -- Understanding the shared bacterial genome -- Computational grammars for interrogation of genomes -- In silico discovery of chemotherapeutic agents -- Informatics for healthcare epidemiology -- Automated, high-throughput surveillance systems for public health -- Microbial genotyping systems for infection control -- Temporal and spatial clustering of bacterial genotypes -- Infectious disease ontology -- Populations, patients, germs and genes: ethics of genomics and informatics in communicable disease control.
- 2014 SpringerBerner, Eta S.This book reviews and defines the current state of the art for informatics education in medicine and health care. This field has undergone considerable change as the field of informatics itself has evolved. Twenty years ago almost the only individuals involved in health care who had even heard the term "informatics" were those who identified themselves as medical or nursing informaticians. Today, we have a variety of subfields of informatics including not just medical and nursing informatics, but informatics applied to specific health professions (such as dental or pharmacy informatics), as well as biomedical informatics, bioinformatics and public health informatics. Informatics Education in Health Care addresses the broad range of informatics education programs available today. The Editor and very experienced internationally recognized informatics educators who have contributed to this work have made the tacit knowledge explicit and shared some of the lessons they have learned. This book therefore represents the key reference for all involved in the informatics education whether they be trainers or trainees.
- 2005 SpringerCowan, Daniel F.
- 2012 CRCnetBASEKagadis, George C.; Langer, Steve G.Ontologies in the radiology department / Dirk Marwede -- Informatics constructs / Steve G. Langer -- Health level 7 imaging integration / Helmut König -- DICOM / Steven C. Horii -- Integrating the healthcare enterprise IHE / Steve G. Langer -- Operating systems / Christos Alexakos and George C. Kagadis -- Networks and networking / Christos Alexakos and George C. Kagadis -- Storage and image compression / Craig Morioka, Frank Meng, and Ioannis Sechopoulos -- Displays / Elizabeth A. Krupinski -- Digital X-ray acquisition technologies / John Yorkston and Randy Luhta -- Efficient database designing / John Drakos -- Web-delivered interactive applications / John Drakos -- Principles of three-dimensional imaging from cone-beam projection data / Frédéric Noo -- Multimodality imaging / Katia Passera, Anna Caroli, and Luca Antiga -- Computer-aided detection and diagnosis / Lioner T. Cheng, Daniel J. Blezek, and Brad J. Erickson -- Picture archiving and communication systems -- Brent K. Stewart -- Hospital information systems, radiology information systems, and electronic medical records / Herman Oosterwijk -- Procurement / Boris Zavalkovskiy -- Operational issues / Shawn Kinzel ... [et al.] -- Teleradiology / Dimitris Karnabatidis and Konstantinos Katsanos -- Ethics in the radiology department / William R. Hendee -- Imaging informatics beyond radiology / Konstantinos Katsanos ... [et al.] -- Informatics in radiation oncology / George Starkschall and Peter Balter.
- 2014 CRCnetBASESiochi, R. Alfredo C.; Starkschall, George."A complete overview of the subject, this book discusses the role of information in the process of radiation oncology, acquisition, communication, and display of data; infrastructure requirements; and the use of data in clinical evaluation and research. It describes essential informatics tools, including various imaging techniques and image management systems, treatment planning systems, radiation oncology management systems, and the electronic medical record. Expert contributors explain how to obtain imaging and other diagnostic information as well as treatment prescriptions, treatment setup and delivery data, and outcome reviews"--Provided by publisher.
- 2011 CRCnetBASEGroom, Frank M.; Jones, Stephan.Ch. 1. Healthcare systems : Introduction / Frank M. Groom -- Ch. 2. Technology as a catalyst for health enhancement / Jane Ellery and Peter J. Ellery -- Ch. 3. Health information exchange / Dave Yoder -- Ch. 4. Universal data standards / Colleen Willis -- Ch. 5. Healthcare information exchange / Kent Supancik -- Ch. 6. Health information technology in the United States : achieving legal and regulatory results that enhance innovation and adoption / Stuart N. Brotman, Gabriel G. Brotman and Jennifer E. Paul -- Ch. 7. Healthcare regulations, privacy, security, and information age considerations / Sydney Morris -- Ch. 8. Usability : patient-physician interactions and the electronic medical record / Carolyn K. Shue and Laura L.S. O'Hara -- Ch. 9. Remembering human factors when implementing technology use : a case study in home healthcare usability / Lori A. Byers -- Ch. 10. Security and privacy : impacts of evolving technologies and legislation / Robert Faix, Chad Cagnolatti, and David Flynn -- Ch. 11. New facility planning : a healthcare focus / Todd Hollowell and Carl Fleming -- Ch. 12. Developing innovative health information for youth : communication theory for practical emerging media applications / Lou Ann Stroup, Chelsey Sigler, and Jay E. Gillette -- Ch. 13. Re-envisioning the IndianaMedicaid.com website as a member-focused portal : a case study on usability and technology for transforming healthcare communication / Jared B. Linder -- Appendix: Glossary of health care terms from IBM.
- 2010 CRCnetBASEHristidis, Vagelis.Overview of XML / Fernando Farfan, Vagelis Hristidis -- Electronic health records / Fernando Farfan, Ramakrishna Varadarajan, and Vagelis Hristidis -- Overview of information discovery techniques on EHRs / Vagelis Hristidis -- Data Quality and integration issues in electronic health records / Ricardo Joao Cruz-Correia ... [et al.] -- Ethical, legal, and social issues for EHR data protection / Reid Cushman -- Searching electronic health records / Ramakrishna Varadarajan ... [et al.] -- Data mining and knowledge discovery on EHRs / Donald J. Berndt, Monica Chiarini Tremblay, and Stephen L. Luther -- Privacy-preserving information discovery on EHRs / Li Xiong ... [et al.] -- Real-time and mobile physiological data analysis / Daniele Apiletti ... [et al.] -- Medical image segmentation / Xiaolei Huang and Gavriil Tschpenakis.
- 2011 SpringerDewan, Naakesh A.; Lorenzi, Nancy M.; Luo, John S.pt. 1. Overview -- pt. 2. Clinical practice issues -- pt. 3. Patient and client centric technologies section -- pt. 4. Organizational issues.
- Information technology framework for predictive, preventive and personalised medicine : a use-case with hepatocellular carcinoma2015 SpringerBerliner, Leonard; Lemke, H. U.Preface -- Introduction -- The Digital Patient Model and Model Guided Therapy -- Hepatocellular Carcinoma and Patient Assessment -- Imaging in Hepatocellular Carcinoma: Radiologic Assessment -- Imaging in Hepatocellular Carcinoma: PET/CT -- Personalized Chemotherapy for Hepatocellular Carcinoma -- Surgical Treatment for Hepatocellular Carcinoma.- Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Technologies -- Chapter 9 Minimally Invasive Therapies for Hepatocellular Cancer: Ablation Therapies -- Minimally Invasive Therapies for Hepatocellular Cancer:Catheter-Directed Therapies -- Radiation Oncology in the Treatment of Hepatocellular Carcinoma -- Design of an IT System for Hepatocellular Carcinoma -- Outlook and Expert Recommendations for Predictive, Preventive and Personalized Medicine and Hepatocellular Carcinoma.
- 2013 SpringerGoundrey-Smith, Stephen.Over the last 30-40 years, information technology (IT) has revolutionized professional life for millions of people around the world. IT has reduced the need for bulk storage of paper records by organizations, has enabled automation of tasks that were previously repetitive and labor-intensive, and carry them out in a fast and accurate way, has enabled economies of scale, improved efficiencies and enabled new ways of working that were hitherto impossible. In parallel with the rise of IT during the last 40 years, the role of the pharmacist - and the society in which pharmacists work - has changed considerably. Pharmacists are no longer principally compounders of medicines, but they are still responsible for ensuring that the patient receives the correct medicine, ensuring that the patient understands why they should take their medicine, and helping the patient with taking the medicine and being concordant with therapy.Information Technology in Pharmacy: an Integrated Approach provides a concise and practical general introduction to pharmacy IT, discusses issues surrounding the adoption of technology and how technologies may be utlilized by the pharmacy profession to exercise new professional roles and achieve new professional aspirations. This book will be of prime interest to practicing pharmacists at all levels, pharmacy students and pharmacy educators, but also to health informaticians, hospital and health care system administrators.
- 2006 SpringerDuplaga, Mariusz; Ingram, David; Zieliński, Krzysztof.
- 2013 SpringerBerkowitz, Lyle; McCarthy, Chris.The healing edge / Lyle Berkowitz and Chris McCarthy -- Mad for method / Chris McCarthy and Christi Dining Zuber -- section 1. You have an EHR: now what?!!?!. The inflection navigator / Lyle Berkowitz -- Making "right" easier / Peter Basch -- Prevention every time / James L. Holly -- Logic rules! / John W. Trudel and Lloyd D. Fisher -- "All or none" bundle philosophy / Thomas R. Graf -- Automatically getting better / David C. Stockwell and Brian R. Jacobs -- section 2. Meet you at 01100101. The connected patient / Jonathan S. Wald -- The virtual consult / Erin DeMarce Leff ... [et al.] -- TeleVisit keeps IT local / Ajay Sood ... [et al.] -- Mommy monitor / Steve Huffman and April R. Daugherty -- Every language now / David D. O'Neill, Susan Anthony, and Margaret Laws -- Rise of the ePharmacists / Mark S. Gagnon and Janell Moerer -- section 3. On the edge of edge. The smartest room / Tamra E. Minnier and David T. Sharbaugh -- One EMR to go please / Steve Flammini and James W. Noga -- Real-time, right care / Debra J. Hurd and Brian D. Patty -- Dashboards 2.0 / George Reynolds -- The patient voice amplified / Valerie M. Sue and Karen Tsang -- The gaming edge / Alex Tam, Vivian Distler, and Bradley Kreit.
- Integration of electronic health records and public biological repositories illuminates human pathophysiology and underlying molecular relationships2011Chen, David Pei-Ann; Altman, Russ B.; Butte, Atul J.; Walker, Michael G.Secondary use of electronic health record (EHR) data has the potential to unlock novel insight into human pathophysiology. While EHR data has often been used in retrospective studies, management of public health, and to improve patient safety, its use in discovering underlying molecular mechanisms of human disease and pathophysiology has been limited. Much of this can be attributed to the differing priorities between healthcare providers and basic biological researchers. The advent of biobanks that collect physiological measurements as well as tissue samples and molecular measurements promises to address this issue. However, the sheer number of different biological and clinical measurement modalities hinders the generation of a truly complete view of the human organism. The increased adoption of EHRs as well as growing biological data repositories enables researchers to answer biological questions applicable to the human population. The goal is not to treat humans as experimental organisms, but rather to gain as much knowledge as possible from every patient seen. By viewing EHRs as a repository of perturbations and their associated physiological consequences we can begin to design experiments that leverage EHR data to generate hypotheses that can be further evaluated. This thesis aims to describe methods to summarize EHR biomarker data in a systematic way to enable downstream analysis as well as methods for integrating EHR data and disparate biological data. I will describe the creation of the "clinarray" and its application to specific disease populations to differentiate patients by severity and to discover latent physiological factors associated with disease. I will also describe how to aggregate and analyze clinarrays from across the EHR to build models of aging. Finally I will discuss the use of diseases to integrate EHR data with gene expression data from a disparate biological data source to discover genes related to aging and to generate hypotheses for relationships between biomarkers and genes. The integration of readily available clinical and biological data promises to improve our understanding of phenomics without impacting patient care and adding an unnecessary burden to the healthcare system. It is important for biological research to leverage the increased amount of molecular and environmental data stored in EHRs to build a more complete view of the human organism.
- 2012 SpringerPowell, Valerie.Rationale and Need to Articulate Medical and Dental Data / Valerie J.H. Powell, Franklin M. Din -- HIT Considerations: Informatics and Technology Needs and Considerations / Miguel Humberto Torres-Urquidy -- Metrics and Measurements / Valerie J.H. Powell, Amit Acharya -- Broader Considerations of Medical and Dental Data Integration / Stephen Foreman, Joseph Kilsdonk -- International Perspectives / Miguel Humberto Torres-Urquidy -- An Integrated Medical-Dental Electronic Health Record Environment: A Marshfield Experience / Amit Acharya, Natalie Yoder, Greg Nycz -- Conclusion and Recommendations / Franklin M. Din, Valerie J.H. Powell.
- 2008 CRCnetBASEBurnham, Keith J.; Haas, Olivier.
- 2013 ScienceDirectAhamed, Syed V.This textbook offers an insightful study of the intelligent Internet-driven revolutionary and fundamental forces at work in society. Readers will have access to tools and techniques to mentor and monitor these forces rather than be driven by changes in Internet technology and flow of money. These submerged social and human forces form a powerful synergistic foursome web of (a) processor technology, (b) evolving wireless networks of the next generation, (c) the intelligent Internet, and (d) the motivation that drives individuals and corporations. In unison, the technological forces can tear human lives apart for the passive or provide a cohesive set of opportunities for the knowledgeable to lead and reap the rewards in the evolved knowledge society. The book also provides in-depth coverage of the functions embedded in modern processors and intelligent communication networks. It focuses on the convergence of the design of modern processor technologies with the switching and routing methodologies of global intelligent networks. Most of the concepts that are generic to the design of terra-flop parallel processors and the terra-bit fiber-optic networks are presented. This book also highlights recent developments in computer and processor technologies into the microscopic and macroscopic medical functions in hospitals and medical centers. Examination of the latest technologies and innovations presented from academic and industrial perspectives of the concurrent dynamic changes in computer and communication industries. An up-to-date and coherent perspective of the developments in the wireless and fiber optic network technologies based on the experience and developments in the older copper, cable and hybrid fiber-coaxial communication systems. Provides a set of novel concepts and methodologies for the innovators in industry -- Source other than Library of Congress.
- 2005 SpringerSilverman, Barry G.Computerization of clinical guidelines : an application of medical document processing / Gersende Georg -- Case-based medical informatics / Stefan V. Pantazi, José F. Arocha and Jochen R. Moehr -- Analysis and architecture of clinical workflow systems using agent-oriented lifecycle models / James P. Davis and Raphael Blanco -- Virtual communities in health care / George Demiris -- Evidence based telemedicine / George Anogianakis ... [et al.] -- Current status of computerized decision support systems in mammography / G.D. Tourassi -- Medical diagnosis and prognosis based on the DNA microarray technology / Y. Fukuoka, H. Inaoka and I.S. Kohane -- Wearable devices in healthcare / Constantine Glaros and Dimitrios I. Fotiadis.
- 2009 SpringerRethlefsen, Melissa L.; Mojon, Daniel S.; Rothman, David L.
- 2006 SpringerHaubold, Bernhard; Wiehe, Thomas.
- 2001 CRCnetBASENorthrop, Robert B.
- 2015 SpringerHannah, Kathryn J.This book is a primer for nurses on the topic of nursing informatics and presents the fundamental concepts of health information management from a nursing perspective. Nursing informatics has never been more important as contemporary healthcare offers exciting opportunities for the nursing profession to contribute to the design of emerging eHealth models of care and to ensure resources such as electronic health records and mobile technology are pragmatic and fit for purpose. This new edition contains the best available evidence to inspire and support nurses to think critically about both current and future practice. Introduction to Nursing Informatics is designed for use by practicing nurses and students in undergraduate programs of study and includes a number of contributions from leading international experts who have practiced in the field over a number of years. The information is presented and integrated in a purposeful manner to encourage readers to explore the key concepts of nursing practice, information management and its relationship to informatics. Critically, the content is also linked to case-based examples to contextualize the theory presented.
- 2006 SpringerHannah, Kathryn J.; Ball, Marion J.; Edwards, Margaret J. A.Also available: Print – 2006
- 2007 SpringerBrennan, Patricia Flatley; Gustafson, David H.; Hawkins, Robert P.Patient-focused technology and the health care delivery system / Patricia Flatley Brennan -- CHESS : translating research into practice / Robert P. Hawkins and Susan Dinauer -- Theory and literature review / Robert P. Hawkins and John Fellows -- Considerations for successful implementation of newly adopted technologies / David H. Gustafson and John Fellows -- Implementation model development and testing / David H. Gustafson, Kuang-Yi Wen, and John Fellows -- Introduction to case studies / David H. Gustafson -- Associated Practice, 1992-1997 / Susan Dinauer, Pauley R. Johnson, Tracy Siegler, Gail Casper, and John Fellows -- Union Hospital, 1993-2001 / Susan Dinauer, Betta Owens, Tracy Siegler, Gail Casper, and John Fellows -- Strand Hardin Health Care, 1995-2002 / Tracy Siegler, Betta Owens, Gail Casper, and John Fellows -- Grace Hospital, 1996-2000 / Pauley R. Johnson, Robert P. Hawkins, Joanna Bates, Gail Casper, and John Fellows -- Simpson Hospital, 1997-2000 / Pauley R. Johnson, Susan Dinauer, Gail Casper, and John Fellows -- Caregiver Resource Center Network, 1999-2002 / Leah Eskenazi, Pauley R. Johnson, Tracy Siegler, Gail Casper, and John Fellows -- Key learning and advice for implementers / David H. Gustafson and Patricia Flatley Brennan.
- Knowledge management for health care procedures : from knowledge to global care, AIME 2007 Workshop K4CARE 2007, Amsterdam, The Netherlands, July 7, 2007 : revised selected papers2008 SpringerRiaño, David.Health care knowledge management: Healthcare Knowledge nmanagement : the art of the possible / Syed Sibte Raza Abidi -- Health care knowledge elicitation -- Health care knowledge transformation -- Health care knowledge-based intelligent systems.
- 2001 ScienceDirectDempster, John.
- 2002 CRCnetBASEPaszko, Christine; Hinton, Mary D.; Turner, Elizabeth.1. Historical Perspective -- 2. LIMS Fundamentals: Overview of Laboratory Information System Development and Project Planning -- 3. Data Management and Basic LIMS: Functional Requirements and Features -- 4. Data Management and Advanced LIMS: Functional Requirements and Features -- 5. Life Cycle of LIMS Software Development -- 6. Regulatory Requirements -- 7. Hardware and Operating System Requirements -- 8. Obtaining Laboratory Personnel Input -- 9. Critical Elements in Preparing a Request for Proposal -- 10. LIMS Evaluations -- 11. Enhancing Data Quality with LIMS -- 12. LIMS Validation -- Appendix A: Sample Request for Proposal -- Appendix B: Sample Scripted Demonstration -- Index.
- 2014 CRCnetBASEGaber, Mohamed Medhat; Sakr, Sherif."This book provides a central source of reference on the various data management techniques of large scale data processing and its technology application. This book presents chapters written by leading researchers, academics, and practitioners in the field, all of which have been reviewed by independent reviewers. The book covers the latest research discoveries and applications. Coverage includes cloud data management architectures, big data analytics visualization, data management, analytics for vast amounts of unstructured data, clustering, classification, link analysis of big data, scalable data mining, and machine learning techniques"-- Provided by publisher.
- 2014 SpringerWickramasinghe, Nilmini.A growing, aging population; the rise to epidemic proportions of various chronic diseases; competing, often overlapping medical technologies; and of course, skyrocketing costs compounded by waste and inefficiency - these are just a few of the multifarious challenges currently facing healthcare delivery. An unexpected source of solutions is being imported from the manufacturing sector: lean thinking. "Lean Principles for Healthcare" presents a conceptual framework, management principles, and practical tools for professionals tasked with designing and implementing modern, streamlined healthcare systems or overhauling faulty ones. Focusing on core components such as knowledge management, e-health, patient-centeredness, and collaborative care, chapters illustrate lean concepts in action across specialties (as diverse as nursing, urology, and emergency care) and around the globe. Extended case examples show health systems responding to consumer needs and provider realities with equal efficiency and effectiveness, and improved quality and patient outcomes. Further, contributors tackle the gamut of technological, medical, cultural, and business issues.
- 2014 SpringerTseng, Charles C.; Yang, Xiaoli.Learning Basic Genetics with Interactive Computer Programs is a comprehensive and interactive learning program that focuses on chromosome simulation and model building. It is intended to assist students in learning more about genetics with ease. The 11 modules of this program form an integrated system for learning the basic concepts of genetics. The program innovation lies in its unique content design that incorporates cognitive feedback and experiential learning through the novel use of interactive applications. Each of the modules is designed to enhance learning by simultaneously employing "eyes-on," "minds-on," and "hands-on" activities. Topics are motivated by questions, information is presented in simple terms, and concepts are clarified by interactive prompts. Used as a supplement to traditional lectures and textbook assignments, the program not only serves as a foundation upon which to build more complex and detailed topics, but as a tutor to clarify and guide when there is confusion. The software that accompanies this book has been shown to be an ideal tool for learning about genetics, which requires a combination of understanding, conceptualization, and practical experience.
- v. 1-3, 2013 Springerpt. 2, 2013 Springerpt. 3, 2013 SpringerCleophas, Ton J. M.; Zwinderman, Aeilko H.
- Making a powerful connection : the health of the public and the national information infrastructure : report of the U.S. Public Health Service, Public Health Data Policy Coordinating Committee, prepared by Roz D. Lasker, Betsy L. Humphreys, William R. Braithwaite.NLMBraithwaite, William R.; Humphreys, Betsy L.; Lasker, Roz D.
- 2013 SpringerSmith, Philip A.Making Computerized Provider Order Entry Work is neither a scientific reference guide into medical informatics nor a book on theory or a summary of research studies in the field, but rather it is a practical guide to visioning and executing successful automation of physician workflow in the hospital environment. This adaptation of workflow is the work of a team, with leadership, clear vision, dedication, commitment, external drivers, experience, and the tireless work of those before us in this industry, who have paved the way with both successes and failure.Throughout the book, the author shares hard lessons-learned and guides the reader through the early warning signs that will help avoid the pitfalls. As systems progress, and the regulatory environments change, there will be new challenges and opportunities that will confront those setting up automated physician workflows. However, this book highlights and discusses all of the principles involved such as vision, leadership, project management and change management, which will always need to be incorporated to ensure project success. As such this book will be an important reference for anyone involved in the setting up or use of such systems from the physicians and medical professionals themselves through the medical informaticist to health system executives and other decision makers.
- 2003 ProQuest SafariTisdall, James D.Also available: Print – 2003
- 2014 CRCnetBASEAgah, Arvin."Artificial Intelligence techniques have been successfully applied to the medical domain, and AI systems are being integrated into healthcare. AI systems can make providing healthcare more accurate, less expensive, more available, and more efficient. They are consistent and can be mass produced. This book includes a number of contributed chapters that detail the most recent advances and research efforts by world-wide experts in the field. The chapters follow the organization of the taxonomy; and offer a clear connection between chapters"--Provided by publisher.
- Medical biometrics : first international conference, ICMB 2008, Hong Kong, China, January 4-5, 2008 : proceedings2007 SpringerZhang, David.
- Medical imaging and informatics : second international conference, MIMI 2007, Beijing, China, August 14-16, 2007 : revised selected papers2008 SpringerGao, Xiaohong.
- 2005 SpringerChen, Hsinchun.Knowledge management, data mining, and text mining in medical informatics -- Mapping medical informatics research -- Bioinformatics challenges and opportunities -- Managing information security and privacy in health care data mining: state of the art -- Ethical and social challenges of electronic health information -- Medical concept representation -- Characterizing biomedical concept relationships: concept relationships as a pathway for knowledge creation and discovery -- Biomedical ontologies -- Information retrieval and digital libraries -- Modeling text retrieval in biomedicine -- Public access to anatomic images -- 3D medical informatics: information science in multiple dimensions -- Infectious disease informatics and outbreak detection -- Semantic interpretation for the biomedical research literature -- Semantic text parsing for patient records -- Identification of biological relationships from text documents -- Creating, modeling and visualizing metabolic networks: FCModeler and PathBinder for network modeling and creation -- Gene pathway text mining and visualization -- The genomic data mine -- Exploratory genomic data analysis -- Joint learning using multiple types of data and knowledge.Also available: Print – 2005
- 2014 SpringerBurgun, Anita; Quantin, Catherine; Venot, Alain.Over the years, medical informatics has matured into a true scientific discipline. Fundamental and applied aspects are now taught in various fields of health, including medicine, dentistry, pharmacy, nursing and public health. Medical informatics is also often included in the curricula of many other disciplines, including the life sciences, engineering and economics. Medical informatics is a complex and rapidly changing discipline. Relatively few books have been published on the subject, and they rapidly become obsolete. This book is the fruit of a collaborative effort between authors teaching medical informatics in France and others who are conducting research in this field. In addition, an international perspective was pursued, as reflected in the inclusion of various developments and actions in both the USA and Europe. This book is divided into 18 chapters, all of which include learning objectives, recommendations for further reading, exercises and bibliographic references.
- 2014 ClinicalKeyCole, Steven A.; Bird, Julian.The Medical Interview by Drs. Steven A. Cole and Julian Bird equips you to communicate effectively with your patients so you can provide optimal care! This best-selling, widely adopted resource presents a practical, systematic approach to honing your basic interviewing skills and managing common challenging communicating situations. Its Three-Function Approach - "Build the Relationship," "Assess and Understand," and Collaborative Management" offers straightforward tasks, behaviors, and skills that can be easily mastered, making this an ideal learning tool for beginners and a valuable reference for experienced healthcare professionals. Effectively meet a full range of communication challenges including language and cultural barriers, sexual issues, elderly patients, breaking bad news, and non-adherence.Also available: Print – 2014
- 2010Blumenthal, David; Rothman, David J.Expecting the unexpected : health information technology and medical professionalism / David Blumenthal -- Quality regulation in the information age : challenges for medical professionalism / Kristen Madison and Mark Hall -- The "information Rx" / Nancy Tomes -- When new is old : professional medical liability in the information age / Sara Rosenbaum and Michael W. Painter -- Patient data : professionalism, property, and policy / Marc Rodwin -- The impact of information technology on organ donation : private values in a public world / Sheila Rothman, Natassia Rozario, and David Rothman -- Changing the rules : the impact of information technology on contemporary maternity practice / Eugene Declercq -- A profession of IT's own : the rise of health information professionals in American health care / Mark C. Suchman and Matthew D. Dimick.
- 2015 SpringerDewan, Naakesh A.; Lorenzi, Nancy M.; Luo, John S.Past, Present and Future Policy Landscape for Technology in Public Mental Health Care -- Electronic Health Records Technology: Policy and Realities -- Leading Health IT Optimization: A Next Frontier -- Computer aided Psychotherapy Technologies -- Cognitive Assessment and Enhancement Technologies -- Digital platform and technology innovation in treatment of substance use disorders -- Technology and Adolescent Behavioral Health Care -- An Overview of Practicing High Quality Telepsychiatry -- Virtual Reality Technologies -- Social Media Technologies -- Technology Tools supportive of DSM-V: An Overview -- Summary and Look Forward.
- Metadata-driven software systems in biomedicine : designing systems that can adapt to changing knowledge2011 SpringerNadkarni, Prakash M.What Is Metadata? -- Data Types in the Medical Record -- Metadata and the Use of XML -- Representing Structured Clinical Data -- Building the User Interface for Structured Clinical Data Capture -- Medical Decision Support Systems: General Considerations -- Challenges in Electronic Decision Support Implementation -- Infrastructure for Complex Clinical Decision Support: Rule Engines -- Decision Support Infrastructure: Workflows and Service-Oriented Architectures -- Complex Decision Support in Practice -- Extending the Entity-Attribute-Value Model -- Descriptive Metadata: An Introduction to Terminologies -- Descriptive Metadata: Implementing Large-Scale Biomedical Ontologies -- Clinical Study Data Management Systems -- Data Retrieval for Heterogeneous Data Models -- Metadata for Data Warehousing -- Biomedical Metadata Standards.
- 2011Dudley, Joel T.; Butte, Atul J.; Kumar, Sudhir; Petrov, Dmitri A.One of the grand challenges in genomic medicine is to translate fundamental scientific discoveries regarding the structure, variation, and function of the genomes of individuals and populations towards improved health outcomes. The main hypothesis of this thesis is that all forms of human genetic variation contributing to the etiology and pathophysiology of modern human diseases have distinct and quantifiable evolutionary histories, which can be computed for every position in the human genome independent of human population characteristics, and used as informative quantitative priors in the discovery and assessment of variants of clinical importance in modern human populations. To enable robust evaluation of the specific questions posed by this thesis, I first explore the necessary properties and theoretical basis for a null evolutionary hypothesis for Evolutionary Genomic Medicine, and conclude that the well-established Neutral Theory of Molecular Evolution provides a sound theoretical and methodological basis for evaluating alternative hypothesis in Evolutionary Genomic Medicine. Due to advances in multiplex genotyping technologies, genome-wide associations studies (GWAS), have emerged as the premier modality for discovery and assessment clinical genomic variation. Although these efforts have been successful in revealing thousands variants robustly associated with a broad spectrum of clinical phenotypes, the variants established by the GWAS approach have so far failed to explain large proportions of the known genetic variance associated with important clinical traits such as Type 2 Diabetes and Hypertension. Because disease-associated variation is linked with genomic loci of functional importance which have undergone evolutionary selection, and even the proxy loci (e.g. tagging SNPs) used to probe for disease associated loci themselves have quantifiable evolutionary histories, I evaluate a compendium of disease-associated variants to evaluate the effect of long-term evolutionary histories on the discovery of disease-associated variants. Through this work I demonstrate that disease-associated variants have distinct evolutionary properties, and that evolutionary features of positions can be incorporated as priors to improve discovery of disease-associated variants. A similar approach is applied to evaluate pharmacogenomics variants associated with warfarin, demonstrating that evolutionary features of genomic positions improve clinical assessment of pharmacogenomics variation. Through the findings and insights gained from efforts in pursuit of my thesis which are reported here, my collaborators and I clearly demonstrate that quantitative evolutionary features can be estimated for each position in the human genome across species, and then applied to modern human population data to improve discovery and assessment of genomic variation associated with clinical phenotypes.
- 2014 ScienceDirectSarkar, Indra Neil.Seeking to cross the bridge among overview, theory, and practice, this book incorporates both methodological approaches and their potential application in the domains associated with biomedical informatics.The multi-contributor book is useful for (1) those coming from a domain seeking biomedical informatics approaches for addressing specific needs; and, (2) current biomedical informaticians seeking a foundational background for methods that might be utilized in practical scenarios germane to their ongoing research.A unique characteristic of the text is its balance between foundational coverage of core topics in biomedical informatics with practical "in-the-trenches" scenarios. Contributors represent leading experts from the biomedical informatics field: individuals who have demonstrated effective use of methodology in real-world, high-quality data applications. Contains appendices that function as primers on: (1) Unix; (2) Ruby; (3) Databases; and (4) Web Services.
- 2013 SpringerDoi, Suhail A. R.; Williams, Gail M."Methods of Clinical Epidemiology" serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level textbook of clinical epidemiology methodology. This book will be of use to postgraduate students in clinical epidemiology as well as clinical researchers at the start of their careers.
- 2010 CRCnetBASEFraser, Karl; Liu, Xiaohui; Wang, Zidong.
- 2013 SpringerSchmitz, Ulf; Vera, Julio; Wolkenhauer, O."This book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology." --Publisher's description.Also available: Print – 2013
- 2011 CRCnetBASELo, David.1. Specification mining : a concise introduction / David Lo ... [et al.] -- 2. Mining finite-state automata with annotations / Leonardo Mariani ... [et al.] -- 3. Adapting grammar inference techniques to mine state machines / Neil Walkinshaw and Kirill Bogdanov -- 4. Mining API usage protocols from large methods traces / Michael Pradel and Thomas R. Gross -- 5. Static API specification mining : exploiting source code model checking / Mithun Acharya and Tao Xie -- 6. Static specification mining using automata-based abstractions / Eran Yahav ... [et al.] -- 7. DynaMine : finding usage patterns and their violations by mining software repositories / Benjamin Livshits and Thomas Zimmermann -- 8. Automatic inference and effective application of temporal specifications / Jinlin Yang and David Evans -- 9. Path-aware static program analyses for specification mining / Muralikrishna Ramanathan, Ananth Grama, and Suresh Jagannathan -- 10. Mining API usage specifications via searching source code from the Web / Suresh Thummalapenta, Tao Xie, and Madhuri R. Marri -- 11. Merlin : specification inference for explicit information flow problems / Benjamin Livshits ... [et al.] -- 12. Lightweight mining of object usage / Andrzej Wasylkowski and Andreas Zeller.
- 2015 Springer ProtocolsHerold, K. E.; Rasooly, Avraham.Mobile device for disease diagnosis and data tracking in resource-limited settings -- Microfluidic devices for nucleic acid (NA) isolation, isothermal NA amplification, and real-time detection -- Mobile based gold nanoprobe TB diagnostics for point-of-need -- Immunofluorescence microtip sensor for point-of-care tuberculosis (TB) diagnosis -- Improving lateral-flow immunoassay (LFIA) diagnostics via biomarker enrichment for mHealth -- Microfluidic toner-based analytical devices: Disposable, lightweight, and portable platforms for point-of-care diagnostics with colorimetric detection -- Detection of protein biomarker using a blood glucose meter -- Microchip ELISA coupled with cell phone to detect ovarian cancer HE4 biomarker in urine -- Point-of-care rare cell cancer diagnostics -- Mobile flow cytometer for mHealth -- Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world -- Opto-fluidics based microscopy and flow cytometry on a cell phone for blood analysis -- Optofluidic device for label-free cell classification from whole blood -- A wearable sensing system for assessment of exposures to environmental volatile organic compounds -- Quantitative point-of-care (POC) assays using measurements of time as the readout: A new type of readout for mHealth -- Smartphone-based fluorescence detector for mHealth -- Two-layer lab-on-a-chip (LOC) with passive capillary valves for mHealth medical diagnostics -- Spectrometry with consumer-quality CMOS cameras -- Mobile phone based electrochemiluminescence detection in paper-based microfluidic sensors -- iStethoscope: A demonstration of the use of mobile devices for auscultation -- iPhysiometer: A smartphone photoplethysmograph for measuring various physiological indices -- Smartphone attachment for stethoscope recording -- Use of smartphones and portable media devices for quantifying human movement characteristics of gait, tendon reflex response, and Parkinson's disease hand tremor -- Measuring tremor with a smartphone -- The use of single-electrode wireless EEG in biobehavioral investigations -- Smartphone based monitoring system for long-term sleep assessment -- Intracranial ventricular catheter placement with a smartphone assisted instrument -- High-resolution microendoscope for the detection of cervical neoplasia -- Skin lesions image analysis utilizing smartphones and cloud platforms -- Melanoma and other skin lesion detection using smart handheld devices.
- 2005 SpringerHaefner, James W.
- 2013 SpringerTang, Wan; Tu, Xin M.This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens. The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.
- 2008 SpringerFrishman, Dmitrij; Valencia, Alfonso.
- 2014 Springer ProtocolsRussell, David James.Dynamic programming / O. Ufuk Nalbantoglu -- Heuristic alignment methods / Osamu Gotoh -- Objective functions / Haluk Dogan and Hasan H. Otu -- Who watches the watchmen? An appraisal of benchmarks for multiple sequence alignment / Stefano Iantorno ... [et al.] -- BLAST and FASTA similarity searching for multiple sequence alignment / William R. Pearson -- Clustal omega, accurate alignment of very large numbers of sequences / Fabian Sievers and Desmond G. Higgins -- T-coffee : tree-based consistency objective function for alignment evaluation / Cedrik Magi ... [et al.] -- MAFFT : iterative refinement and additional methods / Kazutaka Katoh and Daron M. Standley -- Multiple sequence alignment using probcons and probalign / Usman Roshan -- Phylogeny-aware alignment with PRANK / Ari Loytynoja -- GramAlign : fast alignment driven by grammar-based phylogeny / David J. Russell -- Multiple sequence alignment with DIALIGN / Burkhard Morgenstern -- PicXAA : a probabilistic scheme for finding the maximum expected accuracy alignment of multiple biological sequences / Sayed Mohammad Ebrahim Sahraeian and Byung-Jun Yoon -- Multiple protein sequence alignment with MSAProbs / Yongchao Liu and Bertil Schmidt -- Large-scale multiple sequence alignment and tree estimation using SATe / Kevin Liu and Tandy Warnow -- PRALINE : a versatile multiple sequence alignment toolkit / Punto Bawono and Jaap Heringa -- PROMALS3D : multiple protein sequence alignment enhanced with evolutionary and three-dimensional structural information / Jimin Pei and Nick V. Grishin -- MSACompro : improving multiple protein sequence alignment by predicted structural features / Xin Deng and Jianlin Cheng.
- 2012Worldwide, the application of information and communication technologies to support national health-care services is rapidly expanding and increasingly important. This is especially so at a time when all health systems face stringent economic challenges and greater demands to provide more and better care, especially to those most in need. The National eHealth Strategy Toolkit is an expert, practical guide that provides governments, their ministries and stakeholders with a solid foundation and method for the development and implementation of a national eHealth vision, action plan and monitoring framework. All countries, whatever their level of development, can adapt the Toolkit to suit their own circumstances. Representing one of the most significant collaborations in recent years between the World Health Organization and the International Telecommunication Union, the Toolkit is a landmark in understanding what eHealth is, what it can do, and why and how it should be applied to health care today.
- 2013- NCBI BookshelfBeck, Jeff."The NCBI Handbook 2nd Edition is geared towards advanced users of NCBI resources to provide an understanding of how bioinformatics resources at NCBI work. It is not a step-by-step user manual but complements NCBI user guides, tutorials, help information, and other existing documentation. It is our intent that the handbook will reflect, to the extent possible, the current state of databases, resources, and tools at NCBI, with information updated periodically"--Resource home page.
- Airozo, Diana.
- Also available: Print – 2000
- 2007 Springer ProtocolsCrasto, Chiquito Joaquim.Managing knowledge in neuroscience / Chiquito J. Crasto and Gordon M. Shepherd -- Interoperability across neuroscience databases / Luis Marenco ... [et al.] -- Database architectures for neuroscience applications / Prakash Nadkarni and Luis Marenco -- XML for data representation and model specification in neuroscience / Sharon M. Crook and Fred W. Howell -- Creating neuroscience ontologies / Douglas M. Bowden, Mark Dubach, and Jack Park -- Model structure analysis in NEURON / Michael L. Hines, Tom M. Morse, and N.T. Carnevale -- Constructing realistic neural simulations with GENESIS / James M. Bower and David Beeman -- Simulator for neural networks and action potentials / Douglas A. Baxter and John H. Byrne -- Data mining through simulation / William W. Lytton and Mark Stewart -- Computational exploration of neuron and neural network models in neurobiology / Astrid A. Prinz -- Brain atlases and neuroanatomic imaging / Allan MacKenzie-Graham, Jyl Boline, and Arthur W. Toga -- Brain mapping with high-resolution fMRI technology / Nian Liu -- Brain spatial normalization / William Bug ... [et al.] -- Workflow-based approaches to neuroimaging analysis / Kate Fissell -- Databasing receptor distributions in the brain / Rolf Kötter ... [et al.] -- An informatics approach to systems neurogenetics / Glenn D. Rosen -- Computational models of dementia and neurological problems / Włodzisław Duch -- Integrating genetic, functional genomic, and bioinformatics data in a systems biology approach to complex diseases : application to Schizophrenia / F.A. Middleton ... [et al.] -- Alzforum / June Kinoshita and Timothy Clark.
- 2015 SpringerEncarnação, Pedro; Londral, Ana Rita; Rovira, José Luis Pons.
- 2006 Springer ProtocolsNedelkov, Dobrin; Nelson, Randall W.On-chip protein synthesis for making microarrays / Niroshan Ramachandran ... [et al.] -- RCA-enhanced protein detection arrays / Brian B. Haab and Paul M. Lizardi -- Antibody microarrays using resonance light-scattering particles for detection / Bernhard H. Geierstanger, Petri Saviranta, and Achim Brinker -- Chemical proteomics profiling of proteasome activity / Martijn Verdoes ... [et al.] -- Two-dimensional difference gel electrophoresis / Terence L. Wu -- Oligomeric states of proteins determined by size-exclusion chromatography coupled with light scattering, absorbance, and refractive index detectors / Ewa Folta-Stogniew -- Surface plasmon resonance imaging measurements of protein interactions with biopolymer microarrays / Terry T. Goodrich ... [et al.] -- Surface plasmon resonance mass spectrometry for protein analysis / Dobrin Nedelkov and Randall W. Nelson -- High-throughput affinity mass spectrometry / Urban A. Kiernan ... [et al.] -- Isotope-coded affinity tags for protein quantification / Christopher M. Colangelo and Kenneth R. Williams -- Proteomic analysis by multidimensional protein identification technology / Laurence Florens and Michael P. Washburn -- Isolation of glycoproteins and identification of their N-linked glycosylation sites / Hui Zhang and Ruedi Aebersold -- N-Glycosylation analysis using the StrOligo algorithm / Martin Ethier, Daniel Foigeys, and Hélène Perreault -- MALDI-MS data analysis for disease biomarker discovery / Weichuan Yu ... [et al.] -- Using the global proteome machine for protein identification / Ronald C. Beavis.
- 2013 SpringerWong, Lee-Jun C.Overview. History of DNA Sequencing Technologies / Lisa D. White -- Clinical Molecular Diagnostic Techniques: A Brief Review / Megan L. Landsverk, Lee-Jun C. Wong -- The Technologies and Bioinformatics. Methods of Gene Enrichment and Massively Parallel Sequencing Technologies / Hong Cui -- Sequence Alignment, Analysis, and Bioinformatic Pipelines / Fuli Yu, Cristian Coarfa -- Protein Structural Based Analysis for Interpretation of Missense Variants at the Genomics Era: Using MNGIE Disease as an Example / Victor Wei Zhang -- Algorithms and Guidelines for Interpretation of DNA Variants / Jing Wang, Megan Landsverk -- Application to Clinical Diagnosis. NGS-Based Clinical Diagnosis of Genetically Heterogeneous Disorders / C. A. Valencia, T. A. Sivakumaran, B. T. Tinkle -- Molecular Diagnosis of Congenital Disorders of Glycosylation (CDG) / Melanie Jones, Madhuri Hegde -- NGS Improves the Diagnosis of X-Linked Intellectual Disability (XLID) / Michael J. Friez, Monica J. Basehore -- NGS Analysis of Heterogeneous Retinitis Pigmentosa / Rui Chen, Feng Wang -- Next-Generation Sequencing Analyses of the Whole Mitochondrial Genome / Lee-Jun C. Wong -- Application of Next-Generation Sequencing of Nuclear Genes for Mitochondrial Disorders / Valeria Vasta, Si Houn Hahn -- Noninvasive Prenatal Diagnosis Using Next-Generation Sequencing / Nancy Bo Yin Tsui, Yuk Ming Dennis Lo -- Compliance with CAP/CLIA Regulations. Guidelines and Approaches to Compliance with Regulatory and Clinical Standards: Quality Control Procedures and Quality Assurance / Ira M. Lubin, Lisa Kalman, Amy S. Gargis -- Validation of NGS-Based DNA Testing and Implementation of Quality Control Procedures / Victor Wei Zhang, Lee-Jun C. Wong -- Frequently Asked Questions About the Clinical Utility of Next-Generation Sequencing in Molecular Diagnosis of Human Genetic Diseases / Ephrem L. H. Chin, Victor Wei Zhang, Jing Wang, Margherita Milone, Susan Pacheco.
- 2006 MyiLibraryKishore, Rajiv; Ramesh, Ram; Sharman, Raj.
- 2008 CRCnetBASELee, Eva K.; Lim, Gino J.Classification and disease prediction via mathematical programming / Eva K. Lee and Tsung-Lin Wu -- Using influence diagrams in cost-effectiveness analysis for medical decisions / Ram S. Duriseti -- Non-Bayesian classification to obtain high quality clinical decisions / Ram S. Duriseti -- Optimizing pediatric vaccine formularies / Shane N. Hall, Sheldon H. Jacobson, and Edward C. Sewell -- Optimal spending on HIV prevention and treatment : a framework for evaluating cost-effectiveness with example application to the India AIDS initiative / Margaret L. Brandeau ... [et al.] -- Optimization over graphs for kidney paired donation / Sommer E. Gentry -- Introduction to radiation therapy planning optimization / Gino J. Lim -- Beam orientation optimization methods in intensity modulated radiation therapy treatment planning / Dionne M. Aleman, H. Edwin Romeijn, and James F. Dempsey -- Multileaf collimator shape matrix decomposition / Thomas Kalinowski -- Optimal planning for radiation therapy / Mark Langer, Ronald Rardin, and Ali Tuncel -- Introduction to systems biology for mathematical programmers / Eivind Almaas, Allen Holder, and Kevin Livingstone -- Algorithms for genomics analysis / Eva K. Lee and Kapil Gupta -- Computational methods for probe design and selection / Claudio N. Meneses, Panos M. Pardalos, and Michelle A. Ragle -- Implementation of logical analysis of data for oligo probe selection / In-Yong Jang, Kwangsoo Kim, and Hong Seo Ryoo -- New dihedral angle measure for protein secondary prediction / Moon K. Kim, Yunho Jang, and J. MacGregor Smith -- Optimization of tumor virotherapy with recombinant measles viruses / Zeljko Bajzer ... [et al.] -- Combating microbial resistance to antimicrobial agents through dosing regimen optimization / Michael Nikolaou and Vincent H. Tam.
- 2006 SpringerDreyer, Keith J.
- 2010 SpringerKerckhoffs, Roy C. P.Integrating State-of-the-Art Computational Modeling with Clinical Practice: The Promise of Numerical Methods / David E. Krummen, Gainyu Oshodi and Sanjiv M. Narayan -- Patient-Specific Modeling of Cardiovascular Dynamics with a Major Role for Adaptation / Theo Arts, Joost Lumens, Wilco Kroon, Dirk Donker and Frits Prinzen, et al. -- Patient-Specific Modeling of Structure and Function of Cardiac Cells / Frank B. Sachse -- Studies of Therapeutic Strategies for Atrial Fibrillation Based on a Biophysical Model of the Human Atria / Laurent Uldry, Nathalie Virag, Jean-Marc Vesin and Lukas Kappenberger -- Patient-Specific Modeling for Critical Care / Maxwell Lewis Neal -- Biomechanical Analysis of Abdominal Aortic Aneurysms / Lambert Speelman, Mariëlle Bosboom, Geert W. H. Schurink and Frans N. v.d. Vosse -- The Cardiac Atlas Project: Towards a Map of the Heart / Michael Backhaus, Jae Do Chung, Brett R. Cowan, Carissa G. Fonseca and Wenchao Tao, et al. -- In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts / Jonathan F. Wenk, Zhihong Zhang, Guangming Cheng, Kay Sun and Joseph C. Walker, et al. -- Modeling of Whole-Heart Electrophysiology and Mechanics: Toward Patient-Specific Simulations / Fijoy Vadakkumpadan, Viatcheslav Gurev, Jason Constantino, Hermenegild Arevalo and Natalia Trayanova -- Personalized Computational Models of the Heart for Cardiac Resynchronization Therapy / Maxime Sermesant and Reza Razavi -- Patient-Specific Modeling of Hypoxic Response and Microvasculature Dynamics / Joanna Nathan and Amina Ann Qutub -- A Computational Framework for Patient-Specific Multi-Scale Cardiac Modeling / Jazmin Aguado-Sierra, Roy C. P. Kerckhoffs, Fred Lionetti, Darlene Hunt and Chris Villongco, et al.
- 2012 SpringerHutton, John J."Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research. The focus is on the authors' recent practical experiences in establishing an informatics infrastructure in a large research-intensive children's hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine"--Provided by publisher.
- 2009 SpringerJohnson, Kevin B.; Kim, George R.; Lehmann, Christoph U.
- 2005 SpringerChristopherson, Gary A.; Demetriades, James E.; Kolodner, Robert M.Inverted perspectives: triggering change / Tom Munnecke and Robert M. Kolodner -- A window of opportunity / Robert M. Kolodner -- HealthePeople: person-centered, outcomes-driven, virtual health systems / Gary A. Christopherson -- The value of electronic health records / Blackford Middleton -- Personal outcomes in health care / Thomas L. Garthwaite -- Human factors: changing systems, changing behaviors / Marion J. Ball and Judith V. Douglas -- Laying the foundations: information architecture for HealthePeople / James E. Demetriades -- Critical areas of standardization / Jeffrey S. Blair and Simon Cohn -- The role of terminology in future health information systems / Steven H. Brown, Michael J. Lincoln, and Peter L. Elkin -- Modeling for health care / Kenneth S. Rubin, Thomas Beale, and Bernd Blobel -- HealthePeople security architecture / Bernd Blobel and John M. Davis -- Open source health systems / Dipak Katra and David Forslund -- Critical standards convergence / Steven Wagner and J. Michael Fitzmaurice -- A European perspective on the cultural and political context for deploying the electronic health record / Angelo Rossi Mori and Gerard Freriks -- Convergence toward the Pan-Canadian electronic health record / Julie Richards, Shari Dworkin, and Nancy Gill -- HealthConnect: a health information network for all Australians / David Rowlands -- The Veterans Health Administration: quality, value, accountability, and information as transforming strategies / Jonathan B. Perlin and Robert M. Kolodner.
- 2010 SpringerBali, Rajeev K.; Gibbons, Michael Christopher; Wickramasinghe, Nilmini.KM and urban health. Knowledge management for the urban health context / M. Chris Gibbons, Rajeev K. Bali, and Nilmini Wickramasinghe -- Healthcare knowledge management : incorporating the tools technologies strategies and process of KM to effect superior healthcare delivery / Nilmini Wickramasinghe -- Knowledge Management in the urban health context : moving towards tacit-to-tacit knowledge transfer / Rajeev K. Bali, Vikram Baskaran, and Raouf N.G. Naguib -- Incorporating KM principles into urban health contexts. A childhood/adolescent knowledge management system for urban area health programs in the District of Columbia / Michael L. Popovich and Xiaohui Zhang -- Urban health in developing countries / Siddharth Agarwal, Aradhana Srivastava, and Sanjeev Kumar -- A pervasive wireless knowledge management solution to address urban health inequalities with indigenous Australians / Nilmini Wickramasinghe, Indrit Troshani, and Steve Goldberg -- The development of a framework to evaluate the management of HIV/AIDS programmes in rural and urban South Africa / Rochelle Sassman ... [et al.] -- The potential of serious games for improving health and reducing urban health inequalities / M. Chris Gibbons -- Measures and metrics for KM and urban health. A scalable and viable strategy for managing organization : typology of intervening into complex healthcare environment for enhancing its continual development / Murako Saito -- Amplifying resonance in organizational learning process : knowledge sharing for overcoming cognitive barriers and for assuring positive action / Murako Saito -- Developing new urban health metrics to reduce the know-do gap in public health / Carlos Castillo-Salgado and Michael Christopher Gibbons -- Recommendations on evaluation and development of useful metrics for urban health / Carlos Castillo-Salgado and M. Chris Gibbons -- Making sense of urban health knowledge / Rajeev K. Bali ... [et al.].
- 2007 CRCnetBASEBardram, Jakob E.; Mihailidis, Alex; Wan, Dadong.Overview of healthcare, disease, and disability / Jeffrey Kaye, Tracy Zitzelberger -- Computer science tools and techniques / Martha E. Pollack, Bart Peintner -- Pervasive computing in hospitals / Jakob E. Bardram, Heribert Baldus, Jesus Favela -- Pervasive computing in the home and community / Donald J. Patterson, Henry A. Kautz, Dieter Fox, Lin Liao -- Mobile and personal health and wellness management systems / Elina Mattila, Ilkka Korhonen, Niilo Saranummi -- Sensors and wearable technologies for pervasive healthcare / Sungmee Park, Sundaresan Jayaraman -- Assistive technologies / Edmund LoPresti -- Human factors and usability of healthcare systems / Andre Kushniruk, Elizabeth Borycki -- Routes and requirements for realizing pervasive medical devices / Michael P. Craven -- User evaluation in pervasive healthcare / Tim Adlam, Roger Orpwood, Teresa Dunn -- The business of pervasive healthcare / Dadong Wan, Luis E. Taveras.
- 2013 SpringerBali, Rajeev K.Between rising costs and decreasing accessibility, the present health care picture is fraught with shortcomings--a discouraging scenario for the millions of patients struggling with chronic diseases such as diabetes and hypertension. In response, computer technology is emerging as a key factor in the transition from inefficient centralized health systems toward patient-centered, patient-involved care: pervasive healthcare. In straightforward fashion, Pervasive Health Knowledge Management systematically explains how mobile technologies and knowledge management (KM) can streamline health systems by removing time and place limitations, reducing costs, and giving patients a more proactive part in managing their conditions. The book defines the role of KM in pervasive healthcare and analyzes its component processes and technologies. Chapters examine how and why KM works, review KM initiatives within and outside the U.S., and offer extended coverage of possibilities for ubiquitous computing in managing diabetes. Together, they outline a future that meets mounting chronic health concerns with efficient, cost-effective, patient-empowering strategies. Highlights of the coverage: Implicit and explicit knowledge assets in healthcare.Using pervasive technologies to manage knowledge in crisis situations.Smart phone application design and knowledge management for people with dementia.A pervasive technology solution for supporting diabetes self-care.Examining the business and IT aspects of wireless enabled healthcare solutions.Developing an internet-based chronic disease self-management system. Healthcare administrators and researchers in healthcare management, health policy, and health services research will find detailed in Pervasive Health Knowledge Management a visionary approach to many of the most pressing problems in their fields.
- 2012 CRCnetBASEHancock, Monte.What is data mining and what can it do? -- The data mining process -- Problem definition (Step 1) -- Data evaluation (Step 2) -- Feature extraction and enhancement (Step 3) -- Prototyping plan and model development (Step 4) -- Model evaluation (Step 5) -- Implementation (Step 6) -- Supervised learning Genre section 1 - Detecting and characterizing known patterns -- Forensic analysis Genre Section 2 -Detecting, characterizing, and exploiting hidden patterns -- Genre Section 3 - Knowledge : Its acquisition, representation, and use.
- 2007 CRCnetBASEProkscha, Susanne.Also available: Print – 2007
- 2014 SpringerPantanowitz, Liron; Parwani, Anil V.Introduction to informatics / Liron Pantanowitz -- Basic computing / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Networking / Muhammad A. Syed, Anil V. Parwani, and Liron Pantanowitz -- Databases / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Coding / Seung L. Park, Jacqueline Cuda, and Liron Pantanowitz -- Laboratory information systems / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Laboratory information system operations and regulations / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Reporting / Liron Pantanowitz -- Quality management / Liron Pantanowitz, Luke T. Wiehagen, and R. Marshall Austin -- Barcoding / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Informatics projects / Liron Pantanowitz -- Lean Six Sigman / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Electronic medical records / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Digital imaging / Milon Amin, Anil V. Parwani, and Liron Pantanowitz -- Automated pap tests / Liron Pantanowitz -- Telecytology / Sara E. Monaco and Liron Pantanowitz -- Cytology online / Walid E. Khalbuss -- Bioinformatics / Somak Roy, Liron Pantanowitz, and Anil V. Parwani -- Research informatics / Somak Roy, Liron Pantanowitz, Anil V. Parwani.
- 2006 SpringerSinard, John H.
- Primer on clinical experience in medicine : reasoning, decision making, and communication in health sciences2013 CRCnetBASEJenicek, Milos.Ways we see, learn, and practice medicine today : paradigms of what we are doing -- How physicians and other health professionals really (or should) think -- Reasoning in step-by-step clinical work and care : risk, diagnosis, treatment, prognosis -- Clinical and community medicine decision making -- How physicians communicate with themselves, their patients, and others : clinical communication and its vehicles -- Conclusions (with a short recapitulation) : welcome to the world of reasoned and evidence-based medicine.
- 2014 ScienceDirectKalet, Ira.This second edition of a pioneering technical work in biomedical informatics provides a very readable treatment of the deep computational ideas at the foundation of the field. Principles of Biomedical Informatics, 2nd Edition is radically reorganized to make it especially useable as a textbook for courses that move beyond the standard introductory material. It includes exercises at the end of each chapter, ideas for student projects, and a number of new topics, such as: .tree structured data, interval trees, and time-oriented medical data and their use . On Line Application Processing (OLAP), an old database idea that is only recently coming of age and finding surprising importance in biomedical informatics a discussion of nursing knowledge and an example of encoding nursing advice in a rule-based system X-ray physics and algorithms for cross-sectional medical image reconstruction, recognizing that this area was one of the most central to the origin of biomedical computing .an introduction to Markov processes, and an outline of the elements of a hospital IT security program, focusing on fundamental ideas rather than specifics of system vulnerabilities or specific technologies. It is simultaneously a unified description of the core research concept areas of biomedical data and knowledge representation, biomedical information access, biomedical decision-making, and information and technology use in biomedical contexts, and a pre-eminent teaching reference for the growing number of healthcare and computing professionals embracing computation in health-related fields. As in the first edition, it includes many worked example programs in Common LISP, the most powerful and accessible modern language for advanced biomedical concept representation and manipulation. The text also includes humor, history, and anecdotal material to balance the mathematically and computationally intensive development in many of the topic areas. The emphasis, as in the first edition, is on ideas and methods that are likely to be of lasting value, not just the popular topics of the day. Ira Kalet is Professor Emeritus of Radiation Oncology, and of Biomedical Informatics and Medical Education, at the University of Washington. Until retiring in 2011 he was also an Adjunct Professor in Computer Science and Engineering, and Biological Structure. From 2005 to 2010 he served as IT Security Director for the University of Washington School of Medicine and its major teaching hospitals. He has been a member of the American Medical Informatics Association since 1990, and an elected Fellow of the American College of Medical Informatics since 2011. His research interests include simulation systems for design of radiation treatment for cancer, software development methodology, and artificial intelligence applications to medicine, particularly expert systems, ontologies and modeling.
- 2012 SpringerGoundrey-Smith, Stephen.Philosophical and Social Framework of Electronic Medicines Management -- History and Context of Electronic Prescribing in the US and UK -- Organization Benefits of Electronic Prescribing -- EP Systems as a Risk Management Tool -- Data Support for Electronic Medicines Management -- Electronic Medicines Management: Support for Professional Practice -- Electronic Medicines Management and Non-medical Prescribing -- Electronic Prescribing and Future Priorities.
- 2008 SpringerGoundrey-Smith, Stephen.
- 2012 SpringerBenson, Tim.Part 1. Principles of Health Interoperability -- The Health Information Revolution -- Why Interoperability is Hard -- Models -- UML and XML -- Privacy -- Standards Development Organizations -- Part 2. HL7 and Interchange Formats -- HL7 Version 2 -- The HL7 V3 RIM -- Constrained Information Models -- Clinical Document Architecture -- HL7 Dynamic Model -- IHE XDS -- Part 3. SNOMED and Terminology -- Clinical Terminology -- Coding and Classification Schemes -- SNOMED CT -- SNOMED CT Concept Model -- Using SNOMED and HL7 Together.
- 2010 SpringerBenson, Tim.The health information revolution -- Why interoperability is hard -- Models -- UML and XML -- Standards development organizations -- HL7 version 2 -- The HL7 V3 RIM -- Constrained information models -- Clinical document architecture -- HL7 dynamic model and IHE XDS -- Clinical terminology -- SNOMED CT -- Using SNOMED and HL7 together.
- 2005 SpringerDybowski, Richard; Husmeier, Dirk; Roberts, Stephen.A leisurely look at statistical inference / Dirk Husmeier -- Introduction to learning Bayesian networks from data / Dir Husmeier -- A casual view of multi-layer perceptrons as probability models / Richard Dybowski -- Introduction to statistical phylogenetics / Dirk Husmeier -- Detecting recombination in DNA sequence alignments / Dirk Husmeier, Frank Wright -- RNA-based phylogenetic methods / Magnus Rattray, Paul G. Higgs -- Statistical methods in microarray gene expression data analysis / Claus-Dieter Mayer, Chris A. Glasbey -- Inferring genetic regulatory networks from microarray experiments with Bayesian networks / Dirk Husmeier -- Modeling genetic regulatory networks using gene expression profiling and state-space models / Claudia Rangel ... [et al.] -- An anthology of probabilistic models for medical informatics / Richard Dybowski, Stephen Roberts -- Bayesian analysis of population pharmacokinetic/pharmacodynamic models / David J. Lunn -- Assessing the effectiveness of Bayesian feature selection / Ian T. Nabney ... [et al.] -- Bayes consistent classification of EEG data by approximate marginalization / Peter Sykacek, Iead Rezek, and Stephen Roberts -- Ensemble hidden Markov models with extended observation densities for biosignal analysis / Iead Rezek, Stephen Roberts -- A probabilistic network for fusion of data and knowledge in clinical microbiology / Steen Andreassen ... [et al.] -- Software for probability models in medical informatics / Richard Dybowski.
- 2005 CRCnetBASEChang, Kang-Tsung.
- 2007 ProQuest SafariSegaran, Toby.
- 2007 SpringerHouston, Susan M.; Bove, Lisa Anne.
- 2005 SpringerWaksman, Gabriel.
- 2014 SpringerFu, Paul C.; Magnuson, J. A.Part I. Context for Public Health Informatics -- 1. Introduction to Public Health Informatics / J.A. Magnuson and Patrick W. O'Carroll -- 2. History and Significance of Information Systems and Public Health / John R. Lumpkin and J.A. Magnuson -- 3. Context and Value of Biomedical and Health Informatics / William R. Hersh -- 4. Governmental and Legislative Context of Informatics / Margo Edmunds -- Part II. The Science of Public Health Informatics -- 5. Public Health Informatics Infrastructure / Brian E. Dixon and Shaun J. Grannis -- 6. Information Architecture / Dina Dickerson and Patricia Yao -- 7. Data Sources and Data Tools / Edward Mensah and Johanna L. Goderre -- 8. Public Health Information Standards / J.A. Magnuson, Riki Merrick, and James T. Case -- 9. Privacy, Confidentiality, and Security of Public Health Information / William A. Yasnoff -- 10. Electronic Health Records / Stephen P. Julien -- 11. Ethics, Information Technology, and Public Health: Duties and Challenges in Computational Epidemiology / Kenneth W. Goodman and Eric M. Meslin -- 12. Project Management and Public Health Informatics / James Aspevig -- 13. Evaluation for Public Health Informatics / Paul C. Fu, Jr., Herman Tolentino, and Laura H. Franzke -- Part III. Key Public Health Information Systems -- 14. Informatics in Disease Prevention and Epidemiology / Richard S. Hopkins and J.A. Magnuson -- 15. Informatics in Toxicology and Environmental Public Health / Edwin M. Kilbourne -- 16. Public Health Laboratories / Riki Merrick, Steven H. Hinrichs, and Michelle Meigs -- 17. The National Vital Statistics System / Charles J. Rothwell, Mary Anne Freedman, and James A. Weed -- 18. Risk Factor Information Systems / Alan Tomines -- 19. Setting national Policies and Standards for Immunization Information Systems / Nedra Y. Garrett -- Part IV. New Challenges and Emerging Solutions -- 20. New Means of Data Collection and Accessibility / I. Charie Faught, James Aspevig, and Rita Spear -- 21. Geographic Information Systems / Carol L. Hanchette -- 22. Public Health Informatics and Health Information Exchange / J.A. Magnuson and Paul C. Fu, Jr. -- 23. Decision Support and Expert Systems in Public Health / William A. Yasnoff and Perry L. Miller -- 24. Delivery of Preventive Medicine in Primary Care / Paul C. Fu, Jr., Alan Tomines, and Larry L. Dickey -- 25. Case-Based Learning in Public Health Informatics / Herman Tolentino, Sridhar R. Papagari Sangareddy, Catherine Pepper, and J.A. Magnuson -- Part V. Case Studies: Information Systems and the Strata of Public Health -- 26. Local and Regional Public Health Informatics / Jeffrey M. Kriseman and Brian J. Labus -- 27. Public Health Informatics in High Population States: New York and Ohio / Geraldine S. Johnson, Guthrie S. Birkhead, Rachel Block, Shannon Kelley, James Coates, Bob Campbell, and Brian Fowler -- 28. State Public Health Informatics: Perspective from a Low Population State / James Aspevig -- 29. National Public Health Informatics, United States / Seth Foldy -- 30. Public Health Informatics in Canada / Lawrence E. Frisch, Elizabeth M. Borycki, Alyse Capron, Abla Mawudeku, and Ronald St. John -- 31. Perspectives on Global Public Health Informatics / Janise Richards, Gerry Douglas, and Hamish S.F. Fraser -- Part VI. Epilogue -- 32. Public Health Informatics: The Path Forward / J.A. Magnuson.
- 2007Hong, Don; Shyr, Yu.Statistical methodology and stochastic modeling -- Proteomics and genomics -- Survival modeling and analysis -- Mathematical models for diseases -- Computing and visualization.
- 2012 SpringerCecchi, Guillermo A.; Ravishankar Rao, A.Introduction -- Adaptation and contraction theory for the synchronization of complex neural networks -- Temporal coding is not only about cooperation, it is also about competition -- Using non-oscillatory dynamics to disambiguate pattern mixtures -- Functional constraints on network topology via generalized sparse -- Evolution of time in neural networks, from the present to the past, and forward to the future -- Synchronization of coupled pulse-type hardware neuron models for CPG model -- A univesal abstract-time platform for real-time neural networks -- Solving complex control tasks via simple rule(s), using chaotic dynamics in a recurrent neural network model -- Time scale analysis of neuronal ensemble data used to feed neural network models -- Simultaneous EEG-fMRI, integrating spatial and temporal resolution -- Erratum to: Time scale analysis of neuronal ensemble data used to feed neural network models.
- Risques, technologies de l'information pour les pratiques médicales : comptes rendus des treizièmes Journées francophones d'informatique médicale, Nice, 28-30 avril 2009 ...2009 SpringerFieschi, M.
- 2010Levy, Mia Alyce; Das, Amar K.; Fagan, Lawrence M.; Rubin, Daniel.The Rule-Based Response Assessment Framework is a goal-driven, context-driven, and knowledge-based temporal interpretation framework that automates response assessment over clinical data. The goal of this work is to enable consistent application of standardized response criteria for clinical trial data analysis, and to enable research and development of response criteria. The Rule-Based Response Assessment Framework defines the dimensions of response assessment including the knowledge and tasks required to apply response criteria to patient data. The Framework consists of several knowledge models and several sub-methods that make up the Response Assessment Method. The framework is implemented using ontologies and rules with the semantic web formalisms of OWL and SWRL respectively. The framework is applied to two response criteria in the oncology domain and one response criterion for rheumatoid arthritis. I demonstrate that the implementation of the Rule-Based Response Assessment Framework is extensible, reusable and enables consistent application of response criteria to patient data and comparison of response criteria within a clinical domain. Future research directions will incorporate the Rule-Based Response Assessment Framework into a larger informatics infrastructure for application and development of oncology response criteria.
- Sampling-based exploration of the folded state of a protein under kinematic and geometric constraints2010Yao, Peggy; Altman, Russ B.; Latombe, Jean-Claude; Levitt, Michael.The conformational selection model is emerging as one of the best options to model protein flexibility in ligand binding. According to this model, a protein spans an ensemble of rapidly inter-converting folded conformations and a ligand selects the most favorable conformations to bind to from this ensemble. However, only a small number of folded conformations can be obtained experimentally (e.g., from X-ray crystallography, NMR spectrometry, or cryo-electron microscopy), while existing computational techniques (e.g., Molecular Dynamics and Monte-Carlo simulation) are often too expensive to sample conformations broadly distributed across the folded state of a protein. This dissertation focuses on designing new computational methods to efficiently explore the folded state of a protein using kino-geometric sampling approach, i.e., an approach that only considers kinematic constraints (fixed bond lengths and angles) and geometric constraints (no collision of atoms modeled as hard spheres). This approach heavily relies on the fact that in a folded state protein atoms are densely packed. The kino-geometric approach is first applied to loop sampling, where the goal is to explore the conformation space of a loop between two secondary structure elements (helices and/or strands) assuming that the conformation of the rest of the protein is fixed and given as input. Next, it is applied to the considerably more complex problem of sampling folded conformations of an entire protein. In both cases, the proposed methods are validated by showing that the kino-geometric sampler is able to produce a relatively small distribution of conformations (of a loop in the first case, and of an entire protein in the second case) that contains one or more conformations at small Root Means Square Deviation (RMSD) from a "target" conformation. This target conformation is not given to the kino-geometric sampler; therefore, the sampling process is not biased toward this conformation. The main computational difficulties in sampling folded protein conformations result from the large dimensionality of the conformation space and the very small relative volume of the folded subspace. While the small volume of the folded subspace is a necessary precondition for any sampling-based exploration method to work (otherwise a prohibitive number of samples would be required to adequately represent the subspace), it also makes it hard to sample conformations that fall into that subspace. The problem is analogous to looking for a pin in a haystack. For loop conformation sampling, a kino-geometric sampling method based on constraint prioritization is proposed. The idea is to break the loop into several pieces and, for each piece, to achieve the most restrictive constraints (geometric or kinematic) first. The method was tested on loops varying in length from 5 to 25 residues. Its combination with a pre-existing functional site prediction software (FEATURE) makes it possible to compute and recognize calcium-binding loop conformations. To sample folded conformations of an entire protein, this dissertation proposes a set of algorithms integrated into a sampler called KGS. Inspired by two previous kino-geometric samplers (ROCK and FRODA), KGS explores the folded state of a protein by expanding a distribution of conformations from an input folded conformation (usually extracted from the Protein Data Bank). Like ROCK and FRODA, it avoids unfolding the protein by selecting stable hydrogen bonds (H-bonds) and integrates them as additional kinematic constraints. But H-bonds result in a protein kinematic model containing many (often several dozens) interdependent closed kinematic cycles. These cycles considerably complicate sampling operations, as the rotatable dihedral angles can no longer be perturbed independently. The contributions of KGS are threefold: 1. It uses a Jacobian-based method to simultaneously deform many cycles of a protein kinematic structure without breaking them. This method is faster than that of ROCK, and allows deformation steps of greater amplitude than FRODA. 2. KGS embeds a new non-biased diffusive strategy that expands quickly away from the input conformation and progressively samples conformations more and more densely distributed over the folded state. 3. To predict H-bond stability, KGS uses a protein-independent model where energetic contribution is only one predictor among others. This model, trained on molecular dynamics data, has been shown to be 20% more accurate than models based on energy alone. Experiments show that KGS can sample functional (binding) conformations of a protein, given a non-functional (non-binding) one, even when the RMSD between the two conformations is large. This work indirectly demonstrates that kinematic and geometric constraints provide a good characterization of the folded state of a protein, despite the fact that they only implicitly and partially encode electrostatic and van der Waals (vdW) energy terms. On the other hand, it is much faster to handle these kino-geometric constraints computationally than energy functions, which are made of many terms.
- 2013Downey, Autumn S.; Olson, Steve.Pharmaceutical companies, academic researchers, and government agencies such as the Food and Drug Administration and the National Institutes of Health all possess large quantities of clinical research data. If these data were shared more widely within and across sectors, the resulting research advances derived from data pooling and analysis could improve public health, enhance patient safety, and spur drug development. Data sharing can also increase public trust in clinical trials and conclusions derived from them by lending transparency to the clinical research process. Much of this information, however, is never shared. Retention of clinical research data by investigators and within organizations may represent lost opportunities in biomedical research. Despite the potential benefits that could be accrued from pooling and analysis of shared data, barriers to data sharing faced by researchers in industry include concerns about data mining, erroneous secondary analyses of data, and unwarranted litigation, as well as a desire to protect confidential commercial information. Academic partners face significant cultural barriers to sharing data and participating in longer term collaborative efforts that stem from a desire to protect intellectual autonomy and a career advancement system built on priority of publication and citation requirements. Some barriers, like the need to protect patient privacy, present challenges for both sectors. Looking ahead, there are also a number of technical challenges to be faced in analyzing potentially large and heterogeneous datasets. This public workshop focused on strategies to facilitate sharing of clinical research data in order to advance scientific knowledge and public health. While the workshop focused on sharing of data from preplanned interventional studies of human subjects, models and projects involving sharing of other clinical data types were considered to the extent that they provided lessons learned and best practices. The workshop objectives were to examine the benefits of sharing of clinical research data from all sectors and among these sectors, including, for example: benefits to the research and development enterprise and benefits to the analysis of safety and efficacy. Sharing Clinical Research Data: Workshop Summary identifies barriers and challenges to sharing clinical research data, explores strategies to address these barriers and challenges, including identifying priority actions and "low-hanging fruit" opportunities, and discusses strategies for using these potentially large datasets to facilitate scientific and public health advances.
- 2015 SpringerWang, Xiangdong.The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
- 2009 CRCnetBASEWu, Rongling; Lin, Min.Designs and strategies for genomic mapping and haplotyping -- Genetic haplotyping in natural populations -- Genetic haplotyping in experimental crosses -- A general genetic model for genetic haplotyping -- Basic principle of functional mapping -- Functional mapping of pharmacokinetics and pharmacodynamics -- Haplotyping drug response with a pharmacokinetics-pharmacodynamics link model -- Functional mapping of biological clocks -- Genetic mapping of allometric scaling -- Functional mapping of drug response with allometric scaling -- Joint functional mapping of drug efficacy and toxicity -- Modeling epistatic interactions in drug response -- Mapping genotype-environment interactions in drug response -- Nonparametric functional mapping of drug response -- Semiparametric functional mapping of drug response.
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
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- Sabiston Textbook of Surgery
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- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
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