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Laboratory Animal ScienceAccess restricted to Stanford unless otherwise noted

  • Patent and licensing issues in transgenic technology /Karen S. Canady --Global resources : including gene trapped ES cell clones -- is your gene already knocked out /Lluis Montoliu --Designing transgenes for optimal expression /Eduardo Molto, Cristina Vicente-Garcıa, and Lluis Montoliu --Gene targeting vector design for embryonic stem cell modifications /Thomas L. Saunders --Transgenic production benchmarks /Thomas J. Fielder and Lluis Montoliu --Generation of transgenic mice by pronuclear microinjection /Katja Becker and Boris Jerchow --Generation of transgenic rats using microinjection of plasmid DNA or lentiviral vectors /Severine Menoret ... [et al.] --Generation of transgenic animals by use of YACs /Almudena Fernandez, Diego Munoz, and Lluis Montoliu --BAC transgenes, DNA purification, and transgenic mouse production /Michael G. Zeidler, Margaret L. Van Keuren, and Thomas L. Saunders --Generation of transgenic animals with lentiviral vectors /Carlos Lois --Vertebrate transgenesis by transposition /Aron Geurts, Darius Balciunas, and Lajos Mates --Rat spermatogonial stem cell-mediated gene transfer /Karen M. Chapman ... [et al.] --Mouse cloning by nuclear transfer /Sayaka Wakayama, Nguyen Van Thuan, and Teruhiko Wakayama --Gene targeting in embryonic stem cells /Elizabeth D. Hughes and Thomas L. Saunders --Importance of mouse ES cell line selection /Wojtek Auerbach and Anna B. Auerbach --Tetraploid complementation assay /Marina Gertsenstein --Combining ES cells with embryos /Elizabeth Williams ... [et al.] --Derivation of murine ES cell lines /Kristina Nagy and Jennifer Nichols --Rat embryonic stem cell derivation and propagation /Ping Li ... [et al.] --Induced pluripotency : generation of iPS cells from mouse embryonic fibroblasts /Han Li ... [et al.] --Preparation and analysis of DNA for use in transgenic technology /Anna B. Auerbach, Peter J. Romanienko, and Willie H. Mark --Colony management /Karen Brennan --Cryopreservation /B. Pintado and J. Hourcade --Shipment of mice and embryos /Shirley Pease --Pathogen-free mouse rederivation by IVF, natural mating and hysterectomy /J.M. Sztein, R.J. Kastenmayer, and K.A. Perdue --Refinement, reduction, and replacement /Jan Parker-Thornburg.
  • Animal biotechnology 2014, ScienceDirect
    Animal Biotechnology introduces applications of animal biotechnology and implications for human health and welfare. It begins with an introduction to animal cell cultures and genome sequencing analysis and provides readers with a review of available cell and molecular tools. Topics here include the use of transgenic animal models, tissue engineering, nanobiotechnology, and proteomics. The book then delivers in-depth examples of applications in human health and prospects for the future, including cytogenetics and molecular genetics, xenografts, and treatment of HIV and cancers. All this is complemented by a discussion of the ethical and safety considerations in the field. Animal biotechnology is a broad field encompassing the polarities of fundamental and applied research, including molecular modeling, gene manipulation, development of diagnostics and vaccines, and manipulation of tissue. Given the tools that are currently available and the translational potential for these studies, animal biotechnology has become one of the most essential subjects for those studying life sciences. Highlights the latest biomedical applications of genetically modified and cloned animals with a focus on cancer and infectious diseases. Provides firsthand accounts of the use of biotechnology tools, including molecular markers, stem cells, and tissue engineering.
  • Animal hematotoxicology 2008, CRCnetBASE
    Hemopoiesis, blood cell types, and bone marrow examination -- Erythrocytes, anemias, and polycythemia -- Additional erythrocytic measurements -- Iron, associated proteins, and vitamins -- Leukocytes -- Immunotoxicology -- Hemostasis -- Pre-analytical variables -- Analytical variables and biosafety -- Data processing and interpretation.
  • Animal Models for the Study of Human Disease identifies important animal models and assesses the advantages and disadvantages of each model for the study of human disease. The first section addresses how to locate resources, animal alternatives, animal ethics and related issues, much needed information for researchers across the biological sciences and biomedicine.The next sections of the work offers models for disease-oriented topics, including cardiac and pulmonary diseases, aging, infectious diseases, obesity, diabetes, neurological diseases, joint diseases, visual disorders, canc
  • General principles of animal selection and normal physiological values -- Preanesthesia, anesthesia, chemical restraint, and the recognition and treatment of pain and distress -- Normal cardiac function parameters -- Measuring cardiac function -- Measuring vascular function and ventricular/arterial coupling dynamics -- Isolated heart preparations, problems, and pitfalls -- Cardiovascular effects of anesthetics, sedatives, postoperative analgesic agents, and other pharmaceuticals -- Naturally occurring and iatrogenic animal models of valvular, infectious, and arrhythmic cardiovascular disease -- Iatrogenic models of ischemic heart disease -- Iatrogenic, transgenic, and naturally occurring models of cardiomyopathy and heart failure -- Iatrogenic, congenic, and transgenic models of hypertension -- Naturally occurring, iatrogenic and transgenic models of atherosclerotic disease -- Animal models for the study of neurohumeral and central neural control of the cardiovascular system -- Other transgenic animal models used in cardiovascular studies
  • The mouse -- The rat -- The hamster -- The guinea pig -- The rabbit -- The ferret -- The dog -- Primates -- The minipig -- Alternative species / Shayne C. Gad -- Clinical pathology of laboratory animals / Robert L. Hall -- Model selection and scaling / Shayne C. Gad -- Susceptibility factors / Shayne C. Gad -- Laws and regulations governing animal care and use in research / Shayne C. Gad.
  • Pigs in diabetes research with special focus on type 2 diabetes / M.O. Larsen, B. Rolin -- Psammomys obesus : nutritionally induced insulin resistance, diabetes and beta cell loss / E. Ziv, R. Kalman, and E. Shafrir -- The spontaneously diabetic Torii (SDT) rat with human resembling retinopathy lesions / M. Shinohara, T. Masuyama, A. Kakehashi -- The Cohen diabetic rat / S. Weksler-Zangen, E. Orlinsky, D.H. Zangen -- Kk and KKay mice : models of type 2 diabetes and obesity / S. Taketomi -- Animal models to study obesity and type II diabetes induced by diet / Tamer Coskun ... [et al.].Rat models of type 1 diabetes : genetics, environment, and autoimmunity / J.P. Mordes ... [et al.] -- The NOD mouse and its related strains / H. Taniguchi, S. Makino, H. Ikegami -- Obesity/diabetes in mice with mutations in the leptin or leptin receptor genes / S. Chua Jr., L. Herberg, E.H. Leiter -- The Zucker diabetic fatty (ZDF) rat--lessons from leptin receptor defect diabetic model / R.G. Peterson -- The Goto-Kakizaki diabetic rat evolved by selective breeding / C.J. Ostenson -- The new zealand obese mouse : a polygenic model of obesity, glucose intolerance and the metabolic syndrome / B.C. Fam, S. Andrikopoulos -- The JCR:LA-cp rat : a model of the metabolic syndrome exhibiting micro-and macro-vascular disease / J.C. Russel, S.E. Kelly, S.D. Proctor -- The SHROB (Koletsky) rat as a model for metabolic syndrome / R.J. Koletzky, R.A. Velliquette, P. Ernsberger -- OLETF rats : a model for the metabolic syndrome and diabetic nephropathy in humans / K. Kawano -- Neonatally streptrozotocin-induced (n-STZ) diabetic rats, a family of type 2 diabetes models / B. Portha ... [et al.] -- The Rhesus monkey (Macaca mulatta) manifests all features of human type 2 diabetes / B. Hansen and Xenia T. Tigno --
  • Animal welfare 2008, Springer
  • "This book is the first pictorial histopathology atlas with annotations on tuberculosis. The book's drug discovery and animal model perspective makes it applicative rather than academic. Each section will cover the manifestations of induced or acquired pulmonary tuberculosis in one of six animal species (models) - human, non-human primate, rabbit, guinea pig, rat, and mouse. It provides low, medium, and high power microscopy views of lung tissue in color."--Excerpt from publisher notes.
  • 1. Introduction / Piper M. Treuting, Suzanne M. Dintzis, Kathleen S. Montine -- 2. Phenotyping / Cory Brayton, Piper M. Treuting -- 3. Necropsy and Histology / Sue Knoblaugh, Julie Randolph-Habecker, Steve Rath -- 4. Mammary Gland / Robert D. Cardiff, Kimberly H. Allison -- 5. Skeletal System / Christopher Jerome, Benjamin Hoch -- 6. Nose, Sinus, Pharynx, and Larynx / Jack R. Harkema, Stephan A. Carey, James G. Wagner, Suzanne M. Dintzis, Denny Liggitt -- 7. Oral Cavity and Teeth / Piper M. Treuting, Thomas H. Morton Jr. -- 8. Salivary Glands / Piper M. Treuting, Suzanne M. Dintzis -- 9. Respiratory / Carlos Jose Suarez, Suzanne M. Dintzis, Charles W. Frevert -- 10. Cardiovascular / Michael A. Laflamme, Manu M. Sebastian, Bernard S. Buetow -- 11. Upper Gastrointestinal Tract / Piper M. Treuting, Mark A. Valasek, Suzanne M. Dintzis -- 12. Lower Gastrointestinal Tract / Piper M. Treuting, Suzanne M. Dintzis -- 13. Liver and Gallbladder / Arlin B. Rogers, Renee Z. Dintzis -- 14. Pancreas / Suzanne M. Dintzis, Denny Liggitt -- 15. Endocrine System / Krista Marie DuBray La Perle, C. Diana Jordan -- 16. Urinary System / Piper M. Treuting, Jolanta Kowalewska -- 17. Female Reproductive System / Mara H. Rendi, Atis Muehlenbachs, Rochelle L. Garcia, Kelli L. Boyd -- 18. Male Reproductive System / Sue Knoblaugh, Lawrence True -- 19. Hematopoietic and Lymphoid Tissues / Michael Linden, Jerrold M. Ward, Sindhu Cherian -- 20. Nervous System / Catherine E. Hagan, Brad Bolon, C. Dirk Keene -- 21. Special Senses: Eye / Piper M. Treuting, Rachel Wong, Daniel C. Tu, Isabella Phan -- 22. Special Senses: Ear / Piper M. Treuting, Suzanne M. Dintzis -- 23. Skin and Adnexa / John P. Sundberg, Lillian B. Nanney, Philip Fleckman, Lloyd E. King.
  • Diplomatic theory and practice -- International funding for animal protection -- International conferences and delegation management -- The media as a tool for diplomacy -- Important associations and international organizations -- Epilogue
  • Electrocardiography of Laboratory Animals is the only book covering electrocardiography of laboratory animals, including dogs, mini-pigs, and cynomologus monkeys. As more countries institute requirements for the care of laboratory animals in research, this publication offers an effective standard on performing and analyzing ECGs. Topics covered include safety electrocardiography, toxicology, safety pharmacology, and telemetry. Electrocardiography of Laboratory Animals will assist biological and medical researchers, veterinarians, zoologists, and students in understanding electrocardiography of various species of animals used in research. Covers safety electrocardiography of large laboratory animals. Offers comprehensive analysis of ECGs for practical laboratory use. Includes a self-evaluation section for testing of ECG reading and analysis.
  • Bioethics and animal care -- Control of stress and distress -- Management of pain in laboratory animals -- Anesthesia and analgesia -- Euthanasia -- Antibiotics -- Operating theatre -- Rat identification -- Antisepsis, sterilization, and asepsis -- Suture -- Substances administration -- Samples -- Catheterization of the femoral artery and vein -- Cardiac catheterization -- Cannulation of the thoracic duct -- Tracheostomy -- In situ isolation of the stomach -- In situ isolation of the intestinal loop -- Intestinal everted sacs -- In situ perfusion of the small intestine -- Experimental models for the study of diabetes -- Islets of langerhans isolation -- Incubation of pancreatic tissue slices -- In situ perfusion of the pancreas -- Experimental pancreatitis -- Hepatic circulation impairment -- Extrahepatic cholestasis model -- Adrenalectomy -- Ovariectomy -- Thyroparathyroidectomy -- Parathyroid glands -- Measurement techniques of renal parameters -- Kidney isolation and perfusion -- Acute renal failure models -- Renal blood flow measurement -- Transport studies in plasma membrane vesicles isolated from renal cortex -- Remnant kidney model -- Experimental myocardial infarction -- Experimental arteriosclerosis -- Isolated heart: langendorff technique -- Polyclonal antibodies preparation -- Histological procedures -- Bones and bone tissue -- Equipment -- Solution preparation -- Normal values in IIm/Fm rat subline "M".
  • Gene knockout protocols. 2nd ed. 2009, Springer Protocols
    Overview on mouse mutagenesis / Ralf Kühn and Wolfgang Wurst -- Construction of gene-targeting vectors by recombineering / Song-Choon Lee, Wei Wang, and Pentao Liu -- Gene-trap vectors and mutagenesis / Silke De-Zolt ... [et al.] -- Chromosome engineering in ES cells / Louise vander Weyden, Charles Shaw-Smith, and Allan Bradley -- Gene modification in embryonic stem cells by single-stranded DNA oligonucleotides / Marieke Aarts ... [et al.] -- Generation of shRNA transgenic mice / Christiane Hitz ... [et al.] -- Mutagenesis of mouse embryonic stem cells with ethylmethanesulfonate / Robert Munroe and John Schimenti -- Gene targeting in mouse embryonic stem cells / Lino Tessarollo ... [et al.] -- Manipulating mouse embryonic stem cells / Eileen Southon and Lino Tessarollo -- ES cell line establishment / Heidrun Kern and Branko Zevnik -- Generation of double-knockout embryonic stem cells / Eva Wielders, Marleen Dekker, and Hein te Riele -- Differentiation analysis of pluripotent mouse embryonic stem (ES) cells in vitro / Insa S. Schroeder ... [et al.] -- Cloning of ES cells and mice by nuclear transfer / Sayaka Wakayama, Satoshi Kishigami, and Teruhiko Wakayama -- Isolation, microinjection, and transfer of mouse blastocysts / Susan W. Reid and Lino Tessarollo -- Aggregation chimeras : combining ES cells, diploid, and tetraploid embryos / Mika Tanaka ... [et al.] -- VelociMouse : fully ES cell-derived F0-generation mice obtained from the injection of ES cells into eight-cell-stage embryos / Thomas M. DeChiara ... [et al.] -- Generation of Cre recombinase-expressing transgenic mice using bacterial artificial chromosomes / Jan Rodriguez Parkitna, David Engblom, and Günther Schütz -- Inducible Cre mice / Susanne Feil, Nadejda Valtcheva, and Robert Feil -- Creation and use of a Cre recombinase transgenic database / Andras Nagy, Lynn Mar, and Graham Watts -- Transposon mutagenesis in mice / David A. Largaespada -- Lentiviral transgenesis / Alexander Pfeifer and Andreas Hofmann -- Sperm cryopreservation and in vitro fertilization / Susan Marschall, Auke Boersma, and Martin Hrabé de Angelis -- Influence of genetic background on genetically engineered mouse phenotypes / Thomas Doetschman -- Pathologic phenotyping of mutant mice / Roderick T. Bronson -- Systemic first-line phenotyping / Valérie Gailus-Durner ... [et al.]
  • Overview of designing genetically engineered mouse (GEM) models -- Use of Cre-loxP technology and inducible systems to generate mouse models of cancer -- Using recombineering technology to create genetically engineered mouse models -- Insertional mutagenesis for generating mouse models of cancer -- RCAS/TVA somatic gene transfer method in modeling human cancer -- Target-selected ENU mutagenesis to develop cancer models in the rat -- Tumor pathology of genetically engineered mice: genomic pathology -- Genomic DNA copy number alterations in mouse cancer models and human cancer -- Characterization of chromosomal translocations in mouse models of hematological malignancies using spectral karyotyping, FISH, and immunocytochemistry -- Expression profiling of mouse models of human cancer: model categorization and guidance for preclinical testing -- Imaging mouse models of human cancer -- Identifying mammary epithelial stem and progenitor cells -- Differentiation programs in development and cancer -- Roles of p53 and pRB tumor suppressor networks in human cancer: insight from studies in the engineered mouse -- Mouse models for colorectal cancer -- Src family tyrosine kinases: implications for mammary tumor progression -- Maspin and suppresion of tumor metastasis -- Epigenetic mouse models -- Modeling transforming growth factor-ss signalling in cancer -- Modeling stromal-epithelial interactions -- Utilizing mouse models of human cancer for assessing immune modulation of cancer development -- Transplanted tumor models for preclinical drug testing and the potential benefit of genetically engineered mouse models -- Development and use of genetically tractable preclinical mouse models -- Animal models for breast cancer prevention research -- Oncogene addiction: mouse models and clinical relevance for molecularly targeted therapies -- Mouse models in preclinical drug development: applications to CNS models -- Mouse models of human cancer: role in preclinical testing and personalized medicine -- Mighty, bow how useful? The emerging role of genetically engineered mice in cancer drug discovery and development.
  • "Incorporates new scientific information on common laboratory animals, including aquatic species, and includes extensive references. Provides a framework for the judgments required in the management of animal facilities. This updated and expanded resource of proven value will be important to scientists and researchers, veterinarians, animal care personnel, facilities managers, institutional administrators, policy makers involved in research issues, and animal welfare advocates."--Publisher's description (excerpt).
  • The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy.
  • "This bestseller has been an essential book for all those working with laboratory animals since it was first published in 1994. This fourth edition retains all the classic features that have made it a must-have reference including emphasis on best practice in order to improve animal welfare. The contents have been thoroughly updated and reorganised to make sure it is a really practical book for day-to-day use in the laboratory. The first section of the book covers principles applicable to all species, for example husbandry, handling and the education and training required by scientists and technical staff working with animals in the laboratory. Later chapters focus on specific species or groups of species. New to this edition: Reflects changes in European legislation and their impact on national legislation. Covers recommendations for the education and training of those carrying out animal experiments across Europe. New chapters on ethical considerations and balancing animal welfare with science. New information on environmental enrichment for laboratory animals. Covers advancements in anaesthesia and analgesia and techniques. Spiral bound for ease-of-use as a bench-top reference. This book is ideal for all personnel carrying out scientific procedures using animals, particularly during training and also for the new researcher. It will also be essential reading for study directors designing research programmes, animal technicians and veterinarians working with laboratory animal species"--Provided by publisher.
  • v. 2, 2003 CRCnetBASE
    v. 3, 2005 CRCnetBASE
    v. 1. Essential principles and practices -- v. 2-3. Animal models.
  • Handbook of laboratory animal science. 3rd ed. v. 1, 3, 20011, 2014., CRCnetBASE
    v. 3, 2014 CRCnetBASE
    v. 1. Essential principles and practices. -- v. 2. Animal models.
  • Humanized mice 2008, Springer
    Basic Concept of Development and Practical Application of Animal Models for Human Diseases / Tatsuji Nomura, N. Tamaoki, A. Takakura and H. Suemizu, p. 25-51-- Humanized SCID Mouse Models for Biomedical Research / T. Pearson, D. L. Greiner and L. D. Shultz, p. 53-76 -- NOD/Shi-scid IL2rγnull (NOG) Mice More Appropriate for Humanized Mouse Models / M. Ito, K. Kobayashi and T. Nakahata, p. 77-86 -- Humanizing Bone Marrow in Immune-Deficient Mice / K. Ando, Y. Muguruma and T. Yahata, p. 87-94 -- The Differentiative and Regenerative Properties of Human Hematopoietic Stem/Progenitor cells in NOD-SCID/IL2rγnull Mice / F. Ishikawa, Y. Saito, S. Yoshida, M. Harada and L. D. Shultz, p. 95-107 -- Antigen-Specific Antibody Production of Human B Cells in NOG Mice Reconstituted with the Human Immune System / M. Ito, M. Shiina, Y. Saito, Y. Tokuda and Y. Kametani, et al., p. 109-124 -- Humanized Immune System (HIS) Mice as a Tool to Study Human NK Cell Development / N. D. Huntington and J. P. Di Santo, p. 125-131 -- Human T Cell Development and HIV Infection in Human Hemato-Lymphoid System Mice / S. Baenziger, P. Ziegler, L. Mazzucchelli, L. Bronz and R. F. Speck, et al., p. 133-148 -- Humanized Mice for Human Retrovirus Infection / Y. Koyanagi, Y. Tanaka, M. Ito and N. Yamamoto, p. 149-165 -- Functional and Phenotypic Characterization of the Humanized BLT Mouse Model / A. K. Wege, M. W. Melkus, P. W. Denton, J. D. Estes and J. V. Garcia, p. 167-177 -- Novel Metastasis Models of Human Cancer in NOG Mice / M. Nakamura and H. Suemizu, p. 179-196 -- In Vivo Imaging in Humanized Mice / H. Masuda, H. J. Okano, T. Maruyama, Y. Yoshimura and H. Okano, et al.
  • Preparing for anaesthesia -- Anaesthesia -- Anaesthetic management -- Special techniques -- Analgesia and post-operative care -- Anaesthesia of common laboratory species : special considerations.
  • Laboratory animal welfare 2014, ScienceDirect
    Laboratory Animal Welfare provides a comprehensive, up-to-date look into the new science of animal welfare within laboratory research. Animals specifically considered include rodents, cats and dogs, nonhuman primates, agricultural animals, avian animals and aquatic animals. The book examines the impact of experiment design and environment on animal welfare, as well as emergency situations and euthanasia practices. Readers will benefit from a review of regulations and policy guidelines concerning lab animal use, as well as information on assessing animal welfare. With discussions of the history and ethics of animals in research, and a debate on contemporary and international issues, this book is a go-to resource for laboratory animal welfare.
  • Laboratory animals 2014, ScienceDirect
    1. Same principles, some differences / Javier Guillen and Patri Vergara -- 2. Oversight of research animal welfare in the United States / John F. Bradfield, B. Taylor Bennett, and Cynthia S. Gillett -- 3. Canada's oversight of animal use in science / Gilly Griffin and Michael Baar -- 4. Laboratory animal science legislation in Latin America / Ekaterina Akimovna Botovchenco Rivera [and three others] -- 5. The European framework on research animal welfare regulations and guidelines / Javier Guillen [and three others] -- 6. Israeli legislation and regulation on the use of animals in biological and medical research / Rony Kalman [and three others] -- 7. Animal experimentation in Africa : legislation and guidelines / Amanda R. Hau [and five others] -- 8. Laws, regulations, and guidelines shaping research animal care and use in India / Syed SYH Qadri and Christian E. Newcomer -- 9. Oversight of animal research in China / Kathryn Bayne and Jianfei Wang -- 10. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Far East Asia / Tsutomu Miki-Kurosawa, Jae Hak Park, and Chou-Chu Hong -- 11. Laws, regulations, guidelines, and principles pertaining to laboratory animals in Southeast Asia / Montip Gettayacamin [and eight others] -- 12. Laboratory animals regulations and recommendations for global collaborative research : Australia and New Zealand / John Schofield [and three others].
  • Laboratory ferret 2012, CRCnetBASE
    "This book deals with the care and humane treatment of the laboratory ferret. Renowned for its inquisitive nature, the ferret is helping advance the current state of medical knowledge because its biological characteristics have allowed it to emerge as an important laboratory animal model for the study of human viral respiratory diseases such as influenza"--Provided by publisher.
  • Laboratory fish 2000, ScienceDirect
  • Laboratory mouse 2001, CRCnetBASE
  • Laboratory mouse. 2nd ed. 2012, ScienceDirect
  • Laboratory nonhuman primate 2002, CRCnetBASE
  • Laboratory primate 2005, ScienceDirect
  • The Laboratory Rabbit, Guinea Pig, Hamster, and Other Rodents is a single volume, comprehensive book sanctioned by the American College of Laboratory Animal Medicine (ACLAM), covering the rabbit, guinea pig, hamster, gerbil and other rodents often used in research. This well illustrated reference includes basic biology, anatomy, physiology, behavior, infectious and noninfectious diseases, husbandry and breeding, common experimental methods, and use of the species as a research model. With many expert contributors, this will be an extremely valuable publication for biomedical researchers, laboratory animal veternarians and other professionals engaged in laboratory animal science. A new gold standard publication from the American College of Laboratory Animal Medicine series One stop resource for advancements in the humane and responsible care of: rabbit, guinea pig, hamster, gerbil, chinchilla, deer mouse, kangaroo rat, cotton rat, sand rat, and degu Includes up-to-date, common experimental methods Organized by species for easy access during bench research.
  • Laboratory rat. 2nd ed. 2013, CRCnetBASE
    Important biological features -- Husbandry -- Management -- Veterinary care -- Experimental methodology.
  • Laboratory rat. 2nd ed. 2006, ScienceDirect
    Historical foundations / J. Russell Lindsey and Henry J. Baker -- Ethical and legal perspectives / Beverly J. Gnadt -- Taxonomy and stocks and strains / Hans J. Hedrich -- Morphophysiology / John Hofstetter, Mark A. Suckow, and Debra L. Hickman -- Clinical pathology of the rat / Bruce D. Car ... [et al.] -- Reproduction and breeding / Jeffrey J. Lohmiller and Sonya P. Swing -- Assisted reproductive technologies and genetic modifications in rats / Yuksel Agca and John K. Critser -- Analysis of behavior in laboratory rats / Ian Q. Whishaw ... [et al.] -- Nutrition / Sherry M. Lewis ... [et al.] -- Housing and environment / Robert E. Faith and Jack R. Hessler -- Bacterial, mycoplasmal and mycotic infections / Steven H. Weisbroth, Dannis F. Kohn, and Ron Boot -- Viral disease / Robert O. Jacoby and Diane J. Gaertner -- Parasitic diseases / David G. Baker -- Neoplastic disease / Gary A. Boorman and Jeffrey I. Everitt -- Metabolic, traumatic, and miscellaneous diseases / William W. King and Steven P. Russell --Medical management and diagnostic approaches / Glen Otto and Craig L. Franklin -- Occupational health and safety / Sanford H. Feldman and David N. Easton -- Experimental modeling and research methodology / Michael A. Koch -- Anesthesia and analgesia / George A. Vogler -- Euthanasia and necropsy / Jeffrey I. Everitt and Elizabeth A. Gross -- Integrating biology with rat genomic tools / Carol Moreno-Quinn and Howard J. Jacob -- Gnotobiotics / Philip b. Carter and Henry L. Foster -- Spontaneous, surgically and chemically induced models of disease / Dwight R. Owens -- The nude rat / Martha A. Hanes -- Gerontology and age-associated lesions / Nancy L. Nadon -- Cardiovascular research / Peter G. Anderson, Sanford P. Bishop, and J. Thomas Peterson -- Toxicology / Thomas E. Hamm, Mary Ann Vasbinder, and Angela King-Herbert -- Embryology and teratology / Carol Erb -- Immunology / Veronica Jennings and Dirck Dillehay -- Wild and black rats / Marc Hulin and Robert Quinn.
  • Part I. Clinical Aspects -- 1. History of the Israeli Cohort of Laron Syndrome Patients (1958-2009) / Zvi Laron -- 2. Early Investigations: Characterizations of the Circulating Growth Hormone / Zvi Laron -- 3. Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome / Zvi Laron -- 4. Diagnosis of Laron Syndrome / Zvi Laron -- 5. Genetic Aspects / Orit Shevah and Zvi Laron -- 5.1. Genetic Investigations / Orit Shevah and Zvi Laron -- 5.2. Hypothesis of the Origin of Laron Syndrome / Zvi Laron and Orit Shevah -- 5.3. Are the Pygmies Laron Syndrome Patients? / Zvi Laron -- 6. Clinical Evaluation / Zvi Laron -- 7. Perinatal Development in Laron Syndrome / Zvi Laron and Rivka Kauli -- 8. Linear Growth Pattern of Untreated Laron Syndrome Patients / Zvi Laron and Rivka Kauli -- 9. Head Shape, Size, and Growth of Untreated Patients with Laron Syndrome / Zvi Laron and Rivka Kauli -- 10. Sexual Development in Patients with Laron Syndrome / Zvi Laron and Rivka Kauli -- 11. Sex Hormone Binding Proteins and Sex Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome / Zvi Laron and Rivka Kauli -- 11.1. Sex Hormone Binding Proteins / Zvi Laron -- 11.2. Sex Hormones in Untreated Patients with Laron Syndrome / Zvi Laron and Rivka Kauli -- 12. The Adipose Tissue in Patients with Laron Syndrome / Zvi Laron -- 13. Investigations to Determine the Cause of Obesity in Patients with Laron Syndrome / Zvi Laron, Shira Ginsberg, and Nahum Vaisman -- 14. Nonalcoholic Fatty Liver Disease (NAFLD) in Patients with Laron Syndrome / Zvi Laron -- 15. Serum Lipids in Patients with Laron Syndrome / Zvi Laron -- 16. Adiponectin and Leptin in Laron Syndrome / Zvi Laron and Hannah Kanety -- 17. Muscle Force and Endurance in Untreated Adult and IGF-I Treated Children with Laron Syndrome / Zvi Laron -- 18. Bone Mineral Density in Untreated and IGF-I or Alendronate-Treated Patients with Laron Syndrome / Zvi Laron -- 19. Muscle-Bone Relationship in Patients with Laron Syndrome / Yoram Epstein, Amir Hadid, Zvi Laron, Daniel S. Moran, and Nahum Vaisman -- 19.1. Bone Characteristics / Yoram Epstein, Amir Hadid, Zvi Laron, and Daniel S.Moran -- 19.2. Lean Body Mass (LBM) in Patients with Laron Syndrome / Zvi Laron and Nahum Vaisman -- 20. Imaging Findings in Laron Syndrome / Liora Kornreich and Zvi Laron --21. Ocular Findings in Laron Syndrome / Dan H. Bourla and Dov Weinberger -- 22. Hearing in Patients with Laron Syndrome / Zvi Laron, Omer Zarchi, and Joseph Attias -- 23. The Teeth in Patients with Laron Syndrome / Zvi Laron -- 24. Hair, Skin, and Nails in Patients with Laron Syndrome / Zvi Laron -- 25. Hand, Foot, and Organ Size and Growth in Untreated and IGF-I Treated Patients with Laron Syndrome / Zvi Laron and Aviva Silbergeld -- 25.1. Hand Size and Growth of Untreated and IGF-I Treated Laron Syndrome Patients / Zvi Laron -- 25.2. Foot Size and Growth in Untreated and IGF-I-Treated Patients with Laron Syndrome / Zvi Laron and Aviva Silbergeld -- 25.3 Organ Size / Zvi Laron -- 26. Lifelong Serum Growth Hormone Levels in Patients with Laron Syndrome / Zvi Laron and Orly Efros -- 27. IGF-I Binding Proteins in Laron Syndrome / Zvi Laron -- 28. Serum Prolactin in Untreated and IGF-I Treated Patients with Laron Syndrome / Zvi Laron and Orly Efros -- 29. Thyroid Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome / Zvi Laron and Rivka Kauli -- 30. Insulin Secretion and Carbohydrate Metabolism in Patients with Laron Syndrome: From Hypoglycemia to Diabetes Mellitus / Zvi Laron -- 31. Liver Enzymes in Patients with Laron Syndrome / Zvi Laron and Tsvia Karmon -- 32. The Hematopoietic System in Patients with Laron Syndrome / Zvi Laron -- 33. Cardiovascular Aspects in Laron Syndrome Patients / Mickey Scheinowitz, Micha S. Feinberg, Michael Shechter, Zvi Laron, and Rivka Kauli -- 33.1. Heart Functions in Untreated and IGF-I-Treated Patients with Laron Syndrome / Mickey Scheinowitz, Micha S. Feinberg, and Zvi Laron -- 33.2. Endothelial Function in Adults with Laron Syndrome (Primary Growth Hormone Insensitivity) / Michael Shechter and Zvi Laron -- 33.3. Intimal Thickness of the Extracranial Arteries in Untreated Adult Patients with Laron Syndrome / Zvi Laron -- 33.4. Cardiovascular Disease / Zvi Laron and Rivka Kauli -- 34. Kidney Functions in Untreated and IGF-I Treated Patients with Laron Syndrome / Zvi Laron -- 35. Sleep and Sleep Disorders in Patients with Laron Syndrome / Zvi Laron, Rivka Kauli, and Eyal Rosenzweig -- 35.1. Sleep Quality / Zvi Laron and Rivka Kauli -- 35.2. Severe Obstructive Sleep Apnea (OSA) / Zvi Laron -- 35.3. Additional Polysomnographic Examinations of Patients with Laron Syndrome / Eyal Rosenzweig and Zvi Laron -- 36. Neurological Aspects in Laron Syndrome / Zvi Laron -- 37. Orthopedic Problems in Laron Syndrome / Zvi Laron and Rivka Kauli -- 38. Psychological Aspects in Patients with Laron Syndrome / Zvi Laron -- 39. Adjustment and Rehabilitation Problems of Children, Adolescents, and Adults with Laron Syndrome / Zvi Laron --40. Laron Syndrome Patients with Congenital IGF-I Deficiency Seem Protected from Malignant Diseases / Zvi Laron, Rachel Steuerman, and Orit Shevah -- 41. Lifespan and Mortality of Patients with Laron Syndrome / Zvi Laron -- 42. IGF-I Treatment of Patients with Laron Syndrome / Zvi Laron -- 43. IGF-I Stimulation of Head Growth in Patients with Laron Syndrome / Zvi Laron -- 44. Effects of Long-Term Administration of IGF-I on the Adipose Tissue and Carbohydrate Metabolism in Children with Laron Syndrome / Zvi Laron -- 45. Comparison of the Growth Promoting Response of IGF-I in Children with Laron Syndrome with that of hGH in Children with Isolated GH Deficiency / Zvi Laron -- 46. IGF-I Treatment of Adult Patients with Laron Syndrome / Zvi Laron -- 47. Adverse Effects Encountered During IGF-I Treatment of Patients with Laron Syndrome / Zvi Laron -- 48. Summary of the Clinical History: The Laron Syndrome Clock / Zvi Laron -- Part II. The Growth Hormone Receptor "Null" Mouse or the Laron Mouse -- 49. The Laron Mouse / John J. Kopchick and John D. Blischak -- 50. Role of GH/IGF-I Deficiency in Aging / Edward O. List -- 51. Body Composition, Adipose Tissue, and Energy Balance / Darlene E. Berryman -- 52. Metabolism and Metabolic Regulation / Lucila Sackmann-Sala, D. R. Bailey Miles, and John J. Kopchick -- 53. Skeletal Muscle / Juan Ding and John J. Kopchick -- 54. Cardiac Function in GHR-/- Mice / Diana Cruz-Topete and John J. Kopchick -- 55. Bone / Shigeru Okada and Jacob Wright-Piekarski -- 56. GHR Knockout and the CNS / Elahu S. Gosney and John J. Kopchick -- 57. Cancer / Brian D. Bower and John J. Kopchick -- 58. Reproduction / Bruce Kelder -- 59. Conclusions and Future Studies / John J. Kopchick, Hiroyoshi Tanda, Darlene Berryman, and Zvi Laron.
  • The basics of managing a laboratory animal facility -- The organizational environment -- The management of human resources -- Managing financial resources -- Management of information resources -- Time management -- Leadership.
  • DSU Title III 2002-2012.
  • Chapter 1. Introduction to the Research Process -- Chapter 2. Mice -- Chapter 3. Tests of Mouse Behavior -- Chapter 4. Designs -- Chapter 5. Sample Size -- Chapter 6. Ethics Approval -- Chapter 7. Logistics -- Chapter 8. Getting Ready for Testing -- Chapter 9. Prelude to Data Analysis -- Chapter 10. Domains and Test Batteries -- Chapter 11. Motivating Mice -- Chapter 12. Qualities of Behavioral Tests -- Chapter 13. Task Refinement and Standardization -- Chapter 14. Video Tracking -- Chapter 15. The Laboratory Environment.
  • Post-transcriptional Control of Gene Expression During Mouse Oogenesis /Hugh J. Clarke --Polarity and Asymmetry During Mouse Oogenesis and Oocyte Maturation /Malgorzata Kloc, Rafik M. Ghobrial, Ewa Borsuk and Jacek Z. Kubiak --Chromatin Structure and ATRX Function in Mouse Oocytes /Rabindranath De La Fuente, Claudia Baumann and Maria M. Viveiros --Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy /Zbigniew Polański, Hayden Homer and Jacek Z. Kubiak --Src Protein Kinases in Mouse and Rat Oocytes and Embryos /Mattan Levi, Lihi Ninio-Mani and Ruth Shalgi --Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo /Aurélien Courtois and Takashi Hiiragi --Maternal Control of Mouse Preimplantation Development /Wenjing Zheng and Kui Liu --Preimplantation Mouse Embryo: Developmental Fate and Potency of Blastomeres /Aneta Suwińska --Creation of Trophectoderm, the First Epithelium, in Mouse Preimplantation Development /Yusuke Marikawa and Vernadeth B. Alarcon --Cell Lineage Allocation Within the Inner Cell Mass of the Mouse Blastocyst /Panagiotis Xenopoulos, Minjung Kang and Anna-Katerina Hadjantonakis --Formation of Distinct Cell Types in the Mouse Blastocyst /Samantha A. Morris and Magdalena Zernicka-Goetz --Cell Movements in the Egg Cylinder Stage Mouse Embryo /Bradley Joyce and Shankar Srinivas --Balancing the Dose in the Mouse /Mary E. Donohoe --Mouse Oviduct Development /C. Allison Stewart and Richard R. Behringer --Cell Lineages, Growth and Repair of the Mouse Heart /Fabienne Lescroart and Sigolène M. Meilhac --Cellular Reprogramming During Mouse Development /Zoë D. Burke, Gabriela Miron-Buchacra and David Tosh --Differentiation of Definitive Endoderm from Mouse Embryonic Stem Cells /Peter T. W. Kim and Christopher J. Ong --Mouse and Human Pluripotent Stem Cells and the Means of Their Myogenic Differentiation /I. Grabowska, K. Archacka, A. M. Czerwinska, M. Krupa and M. A. Ciemerych --Stem Cells and Corneal Epithelial Maintenance: Insights from the Mouse and Other Animal Models /Richard L. Mort, Panagiotis Douvaras, Steven D. Morley, Natalie Dorà and Robert E. Hill, et al. --Mouse-Induced Pluripotent Stem Cells /Hui Zhang and Ying Jin --Aging in the Mouse and Perspectives of Rejuvenation Through Induced Pluripotent Stem Cells (iPSCs) /Ken-ichi Isobe, Zhao Cheng, Sachiko Ito and Naomi Nishio.
  • Mouse nervous system 2012, ScienceDirect
    The Mouse Nervous System provides a comprehensive account of the central nervous system of the mouse. The book is aimed at molecular biologists who need a book that introduces them to the anatomy of the mouse brain and spinal cord, but also takes them into the relevant details of development and organization of the area they have chosen to study. The Mouse Nervous System offers a wealth of new information for experienced anatomists who work on mice. The book serves as a valuable resource for researchers and graduate students in neuroscience. * Visualization of brain white matter anatomy via 3D diffusion tensor imaging contrasts enhances relationship of anatomy to function * Systematic consideration of the anatomy and connections of all regions of brain and spinal cord by the authors of the most cited rodent brain atlases * A major section (12 chapters) on functional systems related to motor control, sensation, and behavioral and emotional states, * Full segmentation of 170120+ brain regions more clearly defines structure boundaries than previous point-and-annotate anatomical labeling, and connectivity is mapped in a way not provided by traditional atlases A detailed analysis of gene expression during development of the forebrain by Luis Puelles, the leading researcher in this area. * Full coverage of the role of gene expression during development, and the new field of genetic neuroantomy using site-specific recombinases * Examples of the use of mouse models in the study of neurological illness.
  • Fulltext v. 2 ScienceDirect
    V. 1. Biology and management -- v. 2. Diseases.
  • Rat nervous system. 3rd ed. 2004, ScienceDirect
  • Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • Small animal imaging 2011, Springer
  • Biology, handling, husbandry, and anatomy -- Anesthesia, analgesia, and perioperative care -- Wound closure and integument -- Gastrointestinal procedures --Liver and biliary system -- Pancreas and spleen -- Urinary system and adrenal glands -- The reproductive system -- Cardiothoracic and vascular surgery/chronic intravascular catheterization -- Head and neck surgery/central nervous system -- Musculoskeletal system and orthopedic procedures -- Cardiovascular catheterization, electrophysiology, and imaging laboratory procedures -- Endoscopic, laparoscopic, and minimally invasive surgery -- Xenotransplantation and transgenic technologies --Toxicology -- Radiobiology -- Imaging techniques: CT, MRI, and PET scanning -- Ossabaw Island miniature swine: cardiometabolic syndrome assessment.
  • Transgenic and knockout models of psychiatric disorders: introduction, history, and assessment / Gene S. Fisch -- Transgenic mouse models and human psychiatric disease / Jonathan Flint -- Transgenic and knockout mouse models: the problem of language / Linda J. Hayes and Diana Delgado -- If only they could talk: genetic mouse models for psychiatric disorders / Trevor Humby and Lawrence Wilkinson -- Spinocerebellar ataxia type 1: lessons from modeling a movement disease in mice / Harry T. Orr -- Mouse models of hereditary mental retardation / Hans Welzl ... [et al.] -- How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders? / Simon E. Fisher -- Animal models of autism: proposed behavioral paradigms and biological studies / Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon -- Genetic mouse models of psychiatric disorders: advantages, limitations, and challenges / Joseph A. Gogos and Maria Karayiorgou -- Animal models of psychosis / Stephen I. Deutsch ... [et al.] -- Animal models of anxiety: the ethological perspective / Robert Gerlai, Robert Blanchard, and Caroline Blanchard -- Modeling human anxiety and depression in mutant mice / Andrew Holmes and John F. Cryan -- Mutant mouse models of bipolar disorder: are there any? / Anneloes Dirks, Lucianne Groenink, and Berend Olivier.
  • Introduction: strategies for developing genetically modified mice / Marten H. Hofker -- Genetic modification of the mouse: general technology - pronuclear and blastocyst injection / Jan Willem Voncken -- Generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos / Jérôme Artus and Anna-Katerina Hadjantonakis -- Cryopreservation of mouse spermatozoa and in vitro fertilization / Naomi Nakagata -- Autopsy and histological analysis of the transgenic mouse / Marion J.J. Gijbels and Menno P.J. de Winther -- Transgene design / Bart van de Sluis and Jan Willem Voncken -- Inducible transgenic mouse models / Thomas L. Saunders -- Lentiviral transgenesis / Terunaga Nakagawa and Casper C. Hoogenraad -- Transgenesis in mouse embryonic stem cells / Janine van Ree, Wei Zhou, Ming Li, and Jan M. van Deursen -- Engineering BAC reporter gene constructs for mouse transgenesis / Yu Fu and Peter Maye -- Targeting vector construction through recombineering / Liviu A. Malureanu -- Generating conditional knockout mice / Roland H. Friedel, Wolfgang Wurst, Benedikt Wefers, and Ralf Kühm -- Hypomorphic mice / Darren J. Baker -- MICER targeting vectors for manipulating the mouse genome / Chunbong Liu, Paul F. Szurek, and Y. Eugene Yu -- Knock-in approaches / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Generation of a series of knock-in alleles using RMCE in ES cells / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Selection of targeting mutants from a library of randomly mutagenized ES cells / Kyoji Horie, George Gaitanaris, and Alexander Gragerov -- Generation of genetically modified rodents using random ENU mutagenesis / Ruben van Boxtel and Edwin Cuppen -- Bone marrow transplantations of study gene function in hematopoietic cells / Menno P.J. de Winther and Peter Heeringa -- Adenovirus-mediated gene transfer / Ko Willems van Dijk, Kyriakos E. Kyreos, Frits J. Fallaux, and Jurre Hageman.
  • Translational pain research 2010, CRCnetBASE
    Painful multi-symptom disorders : a systems perspective / C. Richard Chapman -- Neurotrophic factors and nociceptor sensitization / Michael P. Jankowski and H. Richard Koerber -- The role of visceral afferents in disease / Julie A. Christianson and Brian M. Davis -- Cancer pain : from the development of mouse models to human clinical trials / Juan Miguel Jimenez Andrade and Patrick Mantyh -- Therapeutic targeting of peripheral cannabinoid receptors in inflammatory and neuropathic pain states / Igor Spigelman -- Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes / Ichiro Nishimura ... [et al.] -- Transgenic mouse models for the tracing of "pain" pathways / Allan I. Basbaum and João M. Bráz -- Cytokines in pain / Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers -- Glial modulation in pain states : translation into humans / Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo -- On the role of ATP-gated P2X receptors in acute, inflammatory, and neuropathic pain / Estelle Toulme ... [et al.] -- Myalgia and fatigue : translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes / Alan R. Light, Charles J. Vierck, and Kathleen C. Light -- Reflex autonomic responses evoked by group III and IV muscle afferents / Jennifer L. McCord and Marc P. Kaufman -- Central pain as a thalamocortical dysrhythmia : a thalamic efference disconnection? / Kerry D. Walton and Rodolfo R. Llinás -- What can neuroimaging tell us about central pain? / D.S. Veldhuijzen ... [et al.] -- Human brain imaging studies of chronic pain : translational opportunities / A. Vania Apkarian -- Consideration of pharmacokinetic pharmacodynamic relationships in the discovery of new pain drugs / Garth T. Whiteside and Jeffrey D. Kennedy -- Large animal models for pain therapeutic development / Darrell A. Henze and Mark O. Urban -- Drug discovery and development for pain / Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers.
  • Perspectives on the history and evolution of tumor models -- Murine L1210 and P388 leukemias -- Transplantable syngeneic rodent tumors: solid tumors in mice -- B16 murine melanoma: historical perspective on the development of a solid tumor model -- Human tumor xenograft efficacy models -- Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time -- Patient-derived tumor models and explants -- The pediatric preclinical testing program -- Imaging efficacy in tumor models -- Mammary cancer in rats -- Animal models of melanoma -- Experimental animal models for investigating renal cell carcinoma pathogenesis and preclinical therapeutic approaches -- Animal models of mesothelioma -- The use of mouse models to study leukemia/lymphoma and assess therapeutic approaches -- Spontaneous companion animal (pet) cancers -- Genetically engineered mouse models of pancreatic ductal adenocarcinoma -- Transgenic adenocarcinoma of the mouse prostate: a validated model for the identification and characterization of molecular targets and the evaluation of therapeutic agents -- The utility of transgenic mouse models for cancer prevention research -- Models for evaluation of targeted therapies of invasive and metastatic disease -- Animal models of toxicities caused by anti-neoplastic therapy -- Bone marrow as a critical normal tissue that limits drug dose/exposure in preclinical models and the clinic -- Anesthetic considerations for the study of murine tumor models -- Preclinical tumor response end points -- Tumor cell survival -- Apoptosis in vivo -- Transparent window models and intravital microscopy: imaging gene expression, physiological function and therapeutic effects in tumors.

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