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  • 1. History and Biology of Erythropoietin in Hematopoietic and Non-Neural Tissues / Giorgia Melli, Sanjay Keswani and Ahmet Höke, p. 1-13 -- 2. Expression of Erythropoietin and Its Receptor in the Central Nervous System / Hugo Marti and Christian Bauer, p. 15-31 -- 3. Erythropoietin and Neuroprotection in the Central Nervous System: Intracellular Signaling Pathways / Murat Digicaylioglu, p. 33-48 -- 4. Regulation of Erythropoietin Expression in the Nervous System: The Hypoxia Inducible Factor / Juan Chavez and JoAnn Gensert, p. 49-67 -- 5. Erythropoietin Neuroprotection in the Term and Preterm Infant: Safety and Efficacy / Eric Demers and Sandra Juul, p. 69-98 -- 6. Erythropoietin for the Treatment of Acute Ischemic Stroke: Preclinical Rationale / Michael Renzi, Linda Jolliffe, Francis Farrell and Kenneth Rhodes, p. 99-112 -- 7. Erythropoietin Neuroprotection in the Retina / Gundula Rohde, Mathias Bähr and Jochen Weishaupt, p. 113-126 -- 8. Erythropoietin for Treatment of Human Brain Disease: Experience from Proof-of-Concept Trials / Hannelore Ehrenreich and Anna-Leena Sirén, p. 127-145 -- 9. Erythropoietin in Spinal Cord Injury Challenges for a Novel Neuroprotective Strategy / Michael Brines and Anthony Cerami, p. 147-164 -- 10. Erythropoietin and Neuroprotection in the Peripheral Nervous System: In Vivo Studies / W. Campana, p. 165-177 -- 11. An Endogenous Pathway Preventing Axonal Degeneration Mediated by Schwann Cell-Derived Erythropoietin / Sanjay Keswani and Ahmet Höke, p. 179-190 -- 12. Role of Erythropoietin in Inflammatory Pathologies of the CNS/ Pietro Ghezzi, Paolo Bigini and Manuela Mengozzi, p. 191-209 -- 13. Development of Non-Erythropoietic Erythropoietin Variants for Neuroprotection / Lars Torup and Marcel Leist, p. 211-219.
  • The new endocrinologist: evidence-based medicine meets endocrine practice / Victor M. Montori -- A short history of evidence-based medicine / Jeanne Daly -- The philosophy of evidence-based medicine, 15 years later / Gordon H. Guyatt and Jason W. Busse -- Preparing future generations of evidence-based endocrinologists / Michael L. Green -- Finding current best evidence in clinical endocrinology / R. Brian Haynes and Cynthia J. Walker-Dilks -- Integrating evidence into clinical diagnosis / W. Scott Richardson -- Supporting evidence-based endocrine practice / Steven A. Smith and Geoffrey Gates -- Helping patients make decisions at the point of care / Annette M. O'Connor, Dawn Stacey, and France Légaré -- Incorporating evidence into health policy decisions / Eduardo Ortiz and Janelle Guirguis-Blake -- The value of observational studies in endocrinology / L. Joseph Melton III -- The value of clinical investigations in endocrinology / William L. Isley -- Systematic reviews and the Cochrane collaboration in endocrinology / Bernd Richter -- Health-related quality of life of in endocrinology / Holger J. Schnemann and Elie A. Akl -- Using decision analyses in endocrinology / David Aron and Evelyn Mentari -- Clouded thinking: the misguided use of cost-effectiveness analysis and the implications for endocrine interventions / Amiram Gafni -- The value of translational research in diabetes: asking broader questions / Russell E. Glasgow, Elizabeth Bayliss, and Paul A. Estabrooks -- The patient with type 1 diabetes and hypoglycemia / Yogish C. Kudva, Teck-Kim Khoo and Peter J. Tebben -- The patient with medically complicated obesity / Kurt A. Kennel -- The patient at risk of type 2 diabetes: considering prevention / Sarah E. Capes -- The patient with type 2 diabetes and incomplete metabolic control / Sean F. Dinneen and Robert K. Semple -- The patient with diabetes using alternative medicine / Edward J. Mills and Dugald Seely -- The patient with osteoporosis / Clifford J. Rosen and Sue A. Brown -- The neuroendocrinology of medically unexplained syndromes: the example of chronic fatigue syndrome / Jason W. Busse.
  • Hypothalamic-pituitary disorders -- Thyroid disorders -- Adrenal disorders -- Metabolic bone disorders -- Reproductive disorders -- Diabetes mellitus -- Lipid disorders -- Obesity and nutrition -- Multiple endocrine neoplasia -- Carcinoid tumors -- Paraneoplastic endocrine syndromes -- Genetics.
  • This volume represents an up-to-date overview on the major areas of gynecological endocrinology, providing the reader with a complete explanation of female endocrine regulation and metabolism and relevant disorders and treatment. It is published within the International Society of Gynecological Endocrinology (ISGE) Series and is based on the 2013 International School of Gynecological and Reproductive Endocrinology Summer Course. The book covers a very wide range of topics from primary amenorrhea to menopause, from the impact of ovarian surgery on fertility to fertility cryopreservation, from metabolic syndrome and polycystic ovary to premature ovarian failure and from the clinical impact of selective progesterone receptor modulators to the use of progesterone in prevention of premature labor. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women's health as well as interested GPs.
  • This volume offers an up-to-date overview on the major areas of gynecological endocrinology, presenting the latest advances in adolescent gynecological endocrinology, assisted reproduction, menstrual-related disorders, sexuality and transsexualism, polycystic ovary syndrome, myometrial pathology and adenomyosis, obesity and metabolic syndrome, hormonal contraception, premature ovarian failure and menopause. In each chapter the recent advances deriving from basic science and clinical investigations are related to the practical management of the condition under consideration, taking into account the need for individualized therapies. The book is published within the ISGE Book Series, a joint venture between the International Society of Gynecological Endocrinology and Springer and is based on the 2014 International School of Gynecological and Reproductive Endocrinology Winter Course. It will be an important tool for obstetricians and gynecologists, endocrinologists and experts in women?s health as well as interested GPs.
  • The Frozen Section Library series provides concise, user-friendly, site specific handbooks that are well illustrated and highlight the pitfalls, artifacts and differential diagnosis issues that arise in the hurried frozen section scenario. Written by expert surgical pathologists, Frozen Section Library: Endocrine Organs presents common and practical problems including follicular adenoma versus follicular carcinoma, papillary thyroid carcinoma versus reactive change and freezing artifact, follicular variant of papillary thyroid carcinoma, and medullary thyroid carcinoma. Anaplastic carcinoma, thyroid lymphoma, resection margin of a pancreatic endocrine tumor, pheochromocytoma within an adrenal gland and extra- adrenal gland, parathyroid tissue versus a thyroid tissue and versus a lymph node are also explored in detail. All chapters are illustrated with color pictures and accompanied legends. As a handbook for practicing pathologists, this volume is an indispensable aid to diagnosis and for avoiding dangers in one of the most challenging situations that pathologists encounter. Rapid consideration of differential diagnoses and how to avoid traps caused by frozen section artifacts are readily accessible. Tables and charts provide guidance for differential diagnosis of various histological patterns.
  • 2010 ClinicalKey
    Mechanisms of mutation -- Pancreas - Genetic testing in diabetes mellitus: a clinical guide to monogenic diabetes -- Obesity -- Syndromes of severe insulin resistance and/or lipodystrophy -- Pituitary -- Functioning pituitary adenomas -- Diabetes insipidus -- States of pituitary hypofunction -- Thyroid -- Congenital defects of thyroid hormone synthesis -- Developmental abnormalities of the thyroid -- Syndromes of reduced sensitivity to thyroid hormone -- Molecular genetics of thyroid cancer: pathogenetic significance and clinical applications -- Parathyroid and bone -- Genetics of hyperparathyroidism including parathyroid cancer -- Genetic diagnosis of skeletal dysplasias -- Vitamin D disorders -- Adrenal -- Congenital adrenal hyperplasia -- Genetics of adrenocortical tumors (ACT) and hypersecretory syndromes -- Hereditary pheochromocytoma and multiple endocrine neoplasia type 2 (MEN2) -- Genetic conditions associated with congenital adrenocortical insufficiency or glucocorticoid and/or mineralocorticoid resistance -- Reproductive -- Genetic considerations in the evaluation of menstrual cycle irregularities -- Genetic diagnosis of hypogonadotropic hypogonadism and Kallmann syndrome -- Disorders of sex development -- Genetic defects of androgen resistance -- Multisystem disorders -- Multiple endocrine neoplasia type 1 (MEN1) -- Genetics of polyglandular failure -- Growth -- Genetic diagnosis of growth failure -- Counseling and laboratory -- Genetic counseling -- Setting up a laboratory.
  • Genome-wide association studies in type 2 diabetes / Beer, N.L.; McCarthy, M.I. -- Fine mapping type 2 diabetes susceptibility loci / Morris, A.P. -- Whole genome and exome sequencing of type 2 diabetes / Gaulton, K.; Flannick, J.; Fuchsberger, C. -- Genome-wide association studies of glycaemic traits : a magical journey / Florez, J.C.; Barroso, I. -- Genome-wide association studies of obesity and related traits / Mohlke, K.L.; Lindgren, C.M. -- Next-generation sequencing for the diagnosis of monogenic diabetes and discovery of novel aetiologies / Ellard, S.; De Franco, E. -- Whole-exome sequencing of patients with severe disorders of insulin action / Semple, R.; Barroso, I. -- Epigenetic modifications and type 2 diabetes in humans / Ling, C. -- Insights into ?-cell biology and type 2 diabetes pathogenesis from studies of the islet transcriptome / van de Bunt, M.; Morán, I.; FerrerJ.; McCarthy, M.I. -- Genomics of adipose tissue / Pinnick, K.E.; Karpe, F. -- Translating genetic association signals for diabetes and metabolic traits into molecular mechanisms for disease / Rees, M.G.; Gloyn, A.L. -- Understanding molecular mechanisms for diabetes and obesity through mouse models / Merkestein, M.; Cox, R.; Ashcroft, F. -- Genetics of drug response in diabetes / Pearson, E.R.; Florez, J.C. -- Translating advances in our understanding of the genetics of diabetes into the clinic / Gardner, D.S.; Owen, K.R.; Gloyn, A.L.
  • Genetics of obesity 2014
    In the past four years, many genetic loci have been implicated for BMI from the outcomes of genome-wide association studies (GWAS), primarily in adults. Insulin-induced gene 2 (INSIG2) was the first locus to be reported by this method to have a role in obesity, but replication attempts have yielded inconsistent outcomes. The identification of the second locus, the fat mass- and obesity-associated gene (FTO), has been more robustly observed by others. Studies from both FTO knock out and FTO over expression mouse model support the fact that FTO is directly involved in the regulation of energy intake and metabolism in mice, where the lack of FTO expression leads to leanness while enhanced expression of FTO leads to obesity. Along with numerous other studies, a number of genetic variants have been established robustly in the context of obesity, giving us fresh insights into the pathogenesis of the disease. This book provides a comprehensive overview of efforts aimed at uncovering genetic variants associated with obesity, which have been particularly successful in the past 5 years with the advent of genome-wide association studies (GWAS). The Genetics of Obesity covers this state of the art technology and its application to obesity in great detail. Topics include genetics of childhood obesity, genetics of syndromic obesity, copy number variants and extreme obesity, co-morbidities of obesity genetics, and functional follow-up of genetic variants.
  • Microarray-based gene expression analysis of endocrine systems: principles of experimental design and interpretation. -- Gene expression profiles and transcription factors involved in parathyroid hormone signaling in osteoblastic cells. -- Analysis of growth hormone effects on hepatic gene expression in hypophysectomized rats. -- Gene expression profiling in leiomyoma in response to GnRH therapy and TGF-beta. -- Gene profiling analysis of androgen receptor mediated function. -- Interrogating estrogen receptor [alpha] signaling in breast cancer by chromatin immunoprecipitation microarrays. -- Gene expression analysis of the adrenal cortex in health and disease. -- DNA microarray analysis of human uterine decidualization. -- Large-scale DNA microarray data analysis reveals glucocorticoid receptor-mediated breast cancer cell survival pathways. -- Application of microarrays for gene transcript analysis in type 2 diabetes. -- DNA microarray analysis of effects of TSH, iodide, cytokines, and therapeutic agents on gene expression in cultured human thyroid follicles. -- Genomics and polycystic ovary syndrome (PCOS): the use of microarray analysis to identify new candidate genes. -- Microarray analysis of alterations induced by obesity in white adipose tissue gene expression profiling. -- Novel molecular signaling and classification of human clinically nonfunctioning pituitary adenomas identified by microarray and reverse transcription-quantitative polymerase chain reaction. -- Gene expression studies of prostate hyperplasia in prolactin transgenic mice.
  • Ghrelin, the endogenous ligand for the growth hormone secretagogue (GHS) receptor, is critical in the control of food intake and energy balance. The ghrelin receptors are now known to have important physiological properties as modulators of growth hormone release, appetite, glucose homeostasis, metabolism, immune function, neurotransmitter activity, cognitive function and neurodegeneration. Bringing all of this information together in the first comprehensive text on the topic, Ghrelin in Health and Disease provides a state-of-the-art synthesis of the latest work in this area for physicians and physician-scientists. This volume addresses the unique property of ghrelin as a modulator of function. Such a property provides potential utility for safe intervention in a wide variety of disease states. Indeed as we learn more about the basic physiology of ghrelin, the potential for treating new disease targets emerge requiring validation in the clinic. Each chapter in this volume is authored by a leading investigator in the field. The introductory chapter sets the background for the book and provides a superb overview of the relevance of ghrelin to physiology, describing how the discovery of ghrelin has prompted us to completely rethink traditional physiology. The authors conclude their chapters by critically addressing the future translational aspects of ghrelin biology and outlining what key basic research and clinical questions remain to be addressed. An invaluable resource, Ghrelin in Health and Disease distinguishes itself as the first comprehensive title covering all of the molecular and clinical issues relating to ghrelin and advancing our clinical understanding of obesity, growth, and reproductive pathogenesis.
  • Ghrelin system 2013
  • This timely volume provides a comprehensive overview of glucocorticoids and their role in regulating many aspects of physiology and their use in the treatment of disease. The book is broken into four sections that begin by giving a general introduction to glucocorticoids and a brief history of the field. The second section will discuss the effects of glucocorticoids on metabolism, while the third section will cover the effects of glucocorticoids on key tissues. The final section will discuss general topics, such as animal models in glucocorticoid research and clinical implications of glucocorticoid research. Featuring chapters from leaders in the field, this volume will be of interest to both researchers and clinicians.
  • Section I. Development and cell migration -- Section II. GnRH receptors -- Section III. Physiology and regulation.
  • This indispensable volume is designed to facilitate the best possible physician?patient discussion on Graves? disease by providing the most up-to-date evidence-based information in a clinically useful and patient-centric manner. Comprehensive and covering such topics as Professionalism and the Art of Patient-centric Thyroidology, the Immunopathogenesis of Graves? Disease, and the Diagnosis and Management of Thyroid Storm, the book addresses all the important refinements in the treatment of Graves? disease in recent years. These include new indications and contraindications for antithyroid drugs, improved approaches to radioactive iodine therapy, the development of novel surgical techniques, and a better understanding of the combined use of these modalities, among other developments. Also addressed are the advances in the treatment of GO, including the use of disease activity and severity assessments to inform management decisions and the completion of the first randomized controlled therapeutic trials. Developed by a renowned group of internationally respected authorities, Graves? Disease: A Comprehensive Guide for Clinicians is a significant new reference that will be of great interest to all clinicians who treat this debilitating condition.
  • Greenspan's Basic & clinical endocrinology 2011 (9th ed.).
  • Clinical aspects of growth hormone deficiency in adults: an overview / Jørgensen, J.O.L., Christiansen, J.S. -- Epidemiology of adult growth hormone deficiency: prevalence, incidence, mortality and morbidity / Erfurth, E.M. -- Hypopituitarism following traumatic brain injury / Popovic, V. ... [et al.] -- IGF-I measurements: epidemiological and clinical aspects / Juul, A. -- Diagnosis of growth hormone deficiency / Fisker, S., Andersen, M., Orskov, H. -- Clinical monitoring of growth hormone replacement in adults / Gibney, J., Johannsson, G. -- Consequences of growth hormone deficiency for intermediary metabolism and effects of replacement / Norrelund, H. -- Skeletal and cardiac muscle in adults with growth hormone deficiency / Cuneo, R.C., Wallace, J.D. -- Bone metabolism and growth hormone deficiency: experimental and clinical aspects / Ueland, T., Bollerslev, J. -- Growth hormone and fluid homeostasis / Moller, J. -- Growth hormone and body composition / Mersebach, H., Feldt-Rasmussen, U. -- Effects of growth hormone deficiency and growth hormone treatment on quality of life in growth hormone-deficient adults / Arwert, L.I., Berend Deijen, J., Drent, M.L. -- Safety aspects of growth hormone replacement / Waterhouse, M., Monson, J.P.
  • Growth Hormone Receptor in Growth -- Ghrelin in the Regulation of GH Secretion and Other Pituitary Hormones -- Growth Hormone Pulsatility and its Impact on Growth and Metabolism in Humans -- Metabolic Actions of Growth Hormone -- Molecular Genetics of Congenital Growth Hormone Deficiency -- Structural Abnormalities in Congenital Growth Hormone Deficiency -- Genetic Causes of Familial Pituitary Adenomas -- The Epidemiology of Growth Hormone Deficiency -- Diagnosis of Growth Hormone Deficiency in Adults -- Transition from Puberty to Adulthood -- Issues in Long-Term Management of Adults with Growth Hormone Deficiency -- Quality of Life in Acromegaly and Growth Hormone Deficiency -- The Value of GH and IGF-I Measurements in the Management of Acromegaly -- The Role of Somatostatin Analogues in Treatment of Acromegaly -- The Role of External Beam Radiation Therapy and Stereotactic Radiosurgery in Acromegaly -- Mortality and Morbidity in Acromegaly: Impact of Disease Control -- GHR Antagonist: Efficacy and Safety -- Long-Acting Growth Hormone Analogues -- Growth Hormone Supplementation in the Elderly -- Growth Hormone in Sports: Is There Evidence of Benefit?
  • Neuroendocrinology, the discipline concerned with how the nervous system controls hormonal secretion and how hormones control the brain, is pivotal to physiology and medicine. Neuroendocrinology has disclosed and underpins fundamental physiological, molecular biological and genetic principles such as the regulation of gene transcription and translation, the mechanisms of chemical neurotransmission and intracellular and systemic feedback control systems. Reproduction, growth, stress, aggression, metabolism, birth, feeding and drinking and blood pressure are some of the bodily functions that are triggered and/or controlled by neuroendocrine systems. In turn, neuroendocrine dysfunction due to genetic or other deficits can lead, for example, to infertility, impotence, precocious or delayed puberty, defective or excessive growth, obesity and anorexia, Cushing's Syndrome, hypertension or thyroid disorders. These as well as neuroendocrine tumors are some of the themes covered in the 36 chapters of the Handbook. Drafted by internationally acknowledged experts in the field, the Handbook chapters feature detailed up-to-date bibliographies as well as "how do we know?" call out sections that highlight the experimental or technical foundations for major concepts, principles, or methodological advances in each area. Aimed at senior undergraduate and graduate students, post-doctoral fellows and faculty in neuroscience, medicine, endocrinology, psychiatry, psychology and cognate disciplines, the Handbook of Neuroendocrinology satisfies an unmet need that will prove useful at the laboratory bench as well as in the office.
  • Preface -- Foreward -- Mechanisms Underlying Extracellular Calcium Homeostasis -- Preoperative Parathyroid Imaging For the Endocrine Surgeon -- Primary and secondary hyperparathyroidism Testing and Assays -- Symptomatic Primary Hyperparathyroidism Medical therapy -- Surgical Management of Primary Hyperparathyroidism -- Primary Hyperparathyroidism -- Asymptomatic Medical Management -- Surgical Management of Asymptomatic Primary Hyperparathyroidism -- Nonclassic, Extraskeletal Manifestations of Primary Hyperparathyroidism: A Brief Review and Possible Mechanisms -- Secondary Hyperparathyroidism -- Secondary Hyperparathyroidism -- Surgical -- Tertiary Hyperparathyroidism Part I: Pathogenesis, Clinical Features and Medical Management -- Surgical Treatment Of Persistent Hyperparathyroidism After Renal Transplantation -- Bone Density and Fracture Risk in Primary Hyperparathyroidism.-Genetic aspects of Hereditary Hyperparathyroidism -- Hypoparathyroidism and Hypocalcemic states -- Molecular Pathogenesis of Primary Hyperparathyroidism -- Cost-effectiveness of Parathyroidectomy for Primary Hyperparathyroidism.
  • Pt. 1. Genetic disorders of steroids : speakers -- pt. 2. Prenatal diagnosis of congenital adrenal hyperplasia : speakers -- pt. 3. Treatment of congenital adrenal hyperplasia : speakers -- pt. 4. Receptor defects : speakers -- pt. 5. Psychological aspects of intersex : speakers -- pt. 6. Embryology of sex differentiation : speakers -- pt. 7. Disorders of sex differentiation : speakers -- pt. 8. Hormonal hypertension : speakers -- pt. 9. Skeletal biology : speakers -- pt. 10. Posters.
  • Immunoassay techniques / Michael J. Wheeler -- High-performance liquid chromatography for hormone assay / John W. Honour -- Gas chromatography-mass spectrometry / John W. Honour -- An introduction to PCR techniques / Gill Rumsby -- Methods for the investigation of thyroid function / Christine R. Squire -- Assays for LH, FSH, and prolactin / Michael J. Wheeler -- Adrenocorticotropic hormone and related peptides / Les A. Perry -- Measurement of glucocorticoids in biological fluids / Geoff Holder -- Urinary steroid profiling / Norman F. Taylor -- Measurement of aldosterone in blood / Marion L. Cawood -- Measurement of plasma renin activity / Marion L. Cawood -- Measurement of androgens / Michael J. Wheeler -- Measurement of gut hormones in plasma / Shahred Taheri, Mohammed Ghatei, and Steve Bloom -- Measurement of melatonin and 6-sulphatoxymelatonin / Benita Middleton.
  • Thyroid hormone transporters and resistance / T.J. Visser -- Genetics and epigenetics of parathyroid hormone resistance / M. Bastepe -- Gonadotropin resistance / A.C. Latronico, I.J.P. Arnhold -- Clinical and molecular aspects of androgen insensitivity / O. Hiort -- Exploring the molecular mechanisms of glucocorticoid receptor action from sensitivity to resistance / S. Ramamoorthy, J.A. Cidlowski -- ACTH resistance : genes and mechanisms / E. Meimaridou ... [et al.] -- Primary generalized familial and sporadic glucocorticoid resistance (chrousos syndrome) and hypersensitivity / E. Charmandari, T. Kino, G.P. Chrousos -- Pseudohypoaldosteronism / F.G. Riepe -- New aspects of the physiology of the GH-IGF-1 axis / A. Vottero, C. Guzzetti, S. Loche -- Molecular and clinical aspects of GHRH receptor mutations / V. Corazzini, R. Salvatori -- Current issues on molecular diagnosis of GH signaling defects / E. Feigerlova ... [et al.] -- Molecular IGF-1 and IGF-1 receptor defects : from genetics to clinical management / M.J.E. Walenkamp, M. Losekoot, J.M. Wit -- Phenotypes, investigation, and treatment of primary IGF-1 deficiency / M.O. Savage -- Human congenital perilipin deficiency and insulin resistance / K. Kozusko, S. Patel, D.B. Savage.
  • Hormone Therapy: A Clinical Handbook provides a comprehensive overview on hormone replacement therapy, with a range of key features that differentiate it from other titles on the topic. This concise, handy title presents an interdisciplinary approach to the subject, acknowledging that sex hormones affect more than reproductive organs and hot flushes for a deeper understanding of how hormones function. The authors provide a breadth and depth of practical prescribing experience, including many helpful tables and algorithms as well as directions for prescribing hormone therapy in the most effective way.
  • Hormonal control of metabolism by the hypothalamus-autonomic nervous system-liver axis / Kalsbeek, A.; Bruinstroop, E.; Yi, C.-X.; Klieverik, L.; Liu, J.; Fliers, E. -- The blood-brain barrier as a regulator of the gut-brain axis / Schaeffer, M.; Hodson, D.J.; Mollard, P. -- The brain modulates insulin sensitivity in multiple tissues / Parlevliet, E.T.; Coomans, C.P.; Rensen, P.C.N.; Romijn, J.A. -- The important role of sleep in metabolism / Copinschi, G.; Leproult, R. ; Spiegel, K. -- Metabolic interplay between gut bacteria and their host / Duca, F.; Giard, P.; Covasa, M.; Lepage, P. -- The brain-stomach connection / Folgueira, C.; Seoane, L.M.; Casanueva, F.F. -- Prader-Willi syndrome as a model of human hyperphagia / Tauber, M.; Diene, G.; Mimoun, E.; Aabal-Berthoumieu, S.; Mantoulan, C.; Molinas, C.; Muscatelli, F.; Salles, J.P. -- Interactions between the gut, the brain and brown adipose tissue function / van den Beukel, J.C.; Grefhorst, A. -- Gut sweet taste receptors and their role in metabolism / Meyer-Gerspach, A.C.; Wilnerhanssen, B.; Beglinger, C. -- What is the role of metabolic hormones in taste buds of the tongue / Cai, H.; Maudsley, S.; Martin, B. -- Protein PYY and its role in metabolism / Price, S.L.; Bloom, S.R. -- Nutropioids regulate the gut-brain circuit controlling food intake / Mithieux, G. -- Should we consider des-acyl ghrelin as a separate hormone and if so, what does it do? / Delhanty, P.J.D.; Neggers, S.J.; van der Lely, A.J. -- Obestatin : is it really doing something? / Trovato, L.; Gallo, D.; Settanni, F.; Gesmundo, I.; Ghigo, E.; Granata, R.
  • Hypoparathyroidism 2015
    Hypoparathyroidism, a condition in which insufficient parathyroid hormone (PTH) is produced to maintain normocalcemia is associated with a variety of acute and chronic symptoms and complications due to hypocalcemia. Replacement therapy utilizing PTH has long been awaited, and this book is new and very timely as it coincides with the ℗ℓpublication of results on the role of the PTH molecule in the pharmacological management of this disorder. This advance is sparking renewed interest in hypoparathyroidism, which is attributable to neck surgery in most cases and to inherited disorders in a minority. Hypoparathyroidism has been written by acknowledged experts in the field and provides essential, up-to-date information on the pathology, diagnosis, and treatment of the condition. It opens by addressing in detail the anatomy and physiology of the parathyroids and describing the epidemiology and clinical presentation of hypoparathyroidism. The full range of hypoparathyroid disorders are then discussed, including the various genetic forms, postoperative hypoparathyroidism, and other forms of acquired hypoparathyroidism. Individual chapters focus on refractory disease, the impact of the condition on bone, and the management of acute hypocalcemia. Both conventional treatment for hypoparathyroidism and the novel replacement therapy with PTH ℗ℓpeptides are then thoroughly examined. Pseudohypoparathyroidism is also extensively discussed, with information on the various forms, differential diagnosis, and genetic testing. This book will be of interest to all endocrinologists, and also to surgeons and internal medicine physicians. ℗ℓ
  • The IGF system: new developments relevant to pediatric practice / Rosenfeld, R.G. -- Clinical relevance of systemic and local IGF-I / Yakar, S. ... [et al.] -- Cartilage disorders: potential therapeutic use of mesenchymal stem cells / Spagnoli, A., Longobardi, L., O'Rear, L. -- Treatment in animal models / Guan, J. ... [et al.] -- Insulin-like growth factor-I and risk of type 2 diabetes and coronary heart disease: molecular epidemiology / Sandhu, M.S. -- Quantitative measurement of IGF-I and its use in diagnosing and monitoring treatment of disorders of growth hormone secretion / Clemmons, D.R. -- IGF-I and IGFBP-3 assessment in the management of childhood onset growth hormone deficiency / Cianfarani, S., Liguori, A., Germani, D. -- IGFs and IGFBPs in clinical management of adult growth hormone deficiency / Aimaretti, G. ... [et al.] -- Monitoring of insulin-like growth factors during growth hormone treatment: adulthood growth hormone deficiency / Monson, J.P. -- IGFs and IGFBPs in clinical management: GH insensitivity / Savage, M.O. ... [et al.] -- Childhood and adol[e]scent diabetes / Dunger, D.B., Regan, F.M., Acerini, C.L. -- Insulin resistance and type 2 diabetes mellitus: is there a therapeutic role for IGF-1? / Moses, A.C. -- Insulin-like growth factors in the treatment of neurological disease / Leinninger, G.M., Feldman, E.L. -- Insulin-like growth factor system in amyotrophic lateral sclerosis / Wilczak, N., De Keyser, J.
  • Imaging Endocrine "Diseases" in the Fetus / F. E. Avni, F. Rypens, M. Cassart -- Hypophysis and Hypothalamus / Pierre Bessou, Sylviane Hanquinet -- Imaging of the Thyroid and Parathyroid Gland / Rick R. van Rijn, Hein J. Verberne -- Adrenals / Anne M. J. B. Smets, Eline E. Deurloo -- Ambiguous Genitalia / Cinzia Orazi, Marco Cappa, Paolo M. S. Schingo -- Female Pelvis: Precocious Puberty--Primary Amenorrhea / Laurent Garel -- Imaging Endocrine Diseases in Children / K. Rosendahl -- Pancreas / Philippe Petit.
  • This volume on the Impact of Sleep and Sleep Disturbances on Obesity and Cancer continues the transdisciplinary approach of this series with chapters authored by the leading experts in this field, focused on the normal regulation of the restorative sleep associated processes across the lifespan, the major mechanisms of sleep and circadian rhythm disturbances and the behavioral, physiologic, biochemical and molecular consequences of sleep disturbances. ?These areas, in turn, are discussed in relationship to their effects on cancer incidence and progression. Students and research scientists involved in all aspects of energy balance and cancer research and patient care should find this volume useful to better understand the causes, contributions and consequences of sleep and circadian rhythm disturbances and their relation to cancer. The volume outlines many exciting areas where research is needed. In addition to its value for researchers, it should be useful to all physicians and health care personnel who care for cancer patients and cancer survivors to better understand the importance of sleep, consequences of sleep disturbances and benefits of their correction.
  • I. Diagnosis and Treatment: General Principles -- 1. Clinical Approach to Inborn Errors of Metabolism in Pediatrics / Jean-Marie Saudubray -- 2. Inborn Errors of Metabolism in Adults: A Diagnostic Approach to Neurological and Psychiatric Presentations / Frédéric Sedel -- 3. Newborn Screening for Inborn Errors of Metabolism / Bridget Wilcken, Piero Rinaldo, Dietrich Matern -- 4. Diagnostic Procedures: Functional Tests and Post-mortem Protocol / Guy Touati, Fanny Mochel, Daniel Rabier -- 5. Emergency Treatments / Carlo Dionisi-Vici, Hélène Ogier de Baulny -- II. Disorders of Carbohydrate Metabolism -- 6. The Glycogen Storage Diseases and Related Disorders / Pascal Laforêt, David A. Weinstein, G. Peter, A. Smit -- 7. Disorders of Galactose Metabolism / Gerard T. Berry, John H. Walter -- 8. Disorders of the Pentose Phosphate Pathway / Mirjam M.C. Wamelink, Vassili Valayannopoulos, Cornelis Jakobs -- 9. Disorders of Fructose Metabolism / Beat Steinmann, René Santer -- 10. Persistent Hyperinsulinaemic Hypoglycaemia / Pascale de Lonlay, Jean-Marie Saudubray -- 11. Disorders of Glucose Transport / René Santer, Jörg Klepper -- III. Disorders of Mitochondrial Energy Metabolism -- 12. Disorders of Pyruvate Metabolism and the Tricarboxylic Acid Cycle / Linda J. De Meirleir, Michèle Brivet, Angeles Garcia-Cazorla -- 13. Disorders of Mitochondrial Fatty Acid Oxidation and Related Metabolic Pathways / Andrew A.M. Morris, Ute Spiekerkoetter -- 14. Disorders of Ketogenesis and Ketolysis / Andrew A.M. Morris -- 15. Defects of the Respiratory Chain / Arnold Munnich, Agnès Rötig, Marlène Rio -- 16. Creatine Deficiency Syndromes / Sylvia Stöckler-Ipsiroglu, Saadet Mercimek- Mahmutoglu, Gajja S. Salomons -- IV. Disorders of Amino Acid Metabolism and Transport -- 17. Hyperphenylalaninaemia / John H. Walter, Robin H. Lachmann, Peter Burgard -- 18. 18 Disorders of Tyrosine Metabolism / Anupam Chakrapani, Paul Gissen, Patrick McKiernan -- 19. Branched-chain Organic Acidurias/Acidaemias / Hélène Ogier de Baulny, Carlo Dionisi-Vici, Udo Wendel -- 20. Disorders of the Urea Cycle and Related Enzymes / Frits A. Wijburg, Marie-Cécile Nassogne -- 21. Disorders of Sulfur Amino Acid Metabolism / Generoso Andria, Brian Fowler, Gianfranco Sebastio -- 22. Disorders of Ornithine Metabolism / Matthias R. Baumgartner, David Valle -- 23. Cerebral Organic Acid Disorders and Other Disorders of Lysine Catabolism / Georg F. Hoffmann, Stefan Kölker -- 24. Nonketotic Hyperglycinaemia (Glycine Encephalopathy) / Olivier Dulac, Marie-Odile Rolland --25. Disorders of Proline and Serine Metabolism / Jaak Jaeken -- 26. Transport Defects of Amino Acids at the Cell Membrane: Cystinuria, Lysinuric Protein Intolerance and Hartnup Disorder / Kirsti Näntö-Salonen, Harri Niinikoski, Olli G. Simell -- V. Vitamin-Responsive Disorders -- 27. Biotin-responsive Disorders / Matthias R. Baumgartner, Terttu Suormala -- 28. Disorders of Cobalamin and Folate Transport and Metabolism / David Watkins, David S. Rosenblatt, Brian Fowler -- VI. Neurotransmitter and Small Peptide Disorders -- 29. Disorders of Neurotransmission / Àngels García-Cazorla, K. Michael Gibson, Peter T. Clayton -- 30. Disorders in the Metabolism of Glutathione and Imidazole Dipeptides / Ertan Mayatepek, Jaak Jaeken -- 31. Trimethylaminuria and Dimethylglycine Dehydrogenase Deficiency / Valerie Walker, Ron A. Wevers -- VII. Disorders of Lipid and Bile Acid Metabolism -- 32. Dyslipidaemias / Annabelle Rodriguez-Oquendo, Peter O. Kwiterovich, Jr. -- 33. Disorders of Cholesterol Synthesis / Hans R. Waterham, Peter T. Clayton -- 34. Disorders of Bile Acid Synthesis / Peter T. Clayton -- 35. Disorders of Phospholipid and Glycosphingolipid Synthesis / Foudil Lamari, Fréderic Sédel, Jean-Marie Saudubray -- VIII. Disorders of Nucleic Acid and Heme Metabolism -- 36. Disorders of Purine and Pyrimidine Metabolism / Georges van den Berghe, M.-Françoise Vincent, Sandrine Marie -- 37. Disorders of Haem Biosynthesis / Charles Marquez Lourenço, Chul Lee, Karl E. Anderson -- IX. Disorders of Metal Transport -- 38. Disorders in the Transport of Copper, Iron, Magnesium, Manganese, Selenium and Zinc / Marc Bierings, Peter Clayton, Roderick H.J. Houwen -- X. Organelle-Related Disorders: Lysosomes, Peroxisomes, and Golgi and Pre-Golgi Systems -- 39. Disorders of Sphingolipid Metabolism and Neuronal Ceroid-Lipofuscinoses / Marie T. Vanier, Catherine Caillaud -- 40. Mucopolysaccharidoses and Oligosaccharidoses / J. Ed Wraith -- 41. Peroxisomal Disorders / Bwee Tien Poll-The, Patrick Aubourg, Ronald J.A. Wanders -- 42. Congenital Disorders of Glycosylation / Jaak Jaeken -- 43. Cystinosis / Michel Broyer, Patrick Niaudet -- Appendix A. Medications Used in the Treatment of Inborn Errors / JH Walter and JE Wraith.
  • 1. Evaluation for insulin resistance and comorbidities related to insulin resistance in polycystic ovary syndrome / Ricardo Azziz -- 2. Fat distribution and adipose products in polycystic ovary syndrome / Enrico Carmina -- 3. Treatment of infertility in polycystic ovary syndrome: ovulation induction / Deborah S. Wachs and R. Jeffery Chang -- 4. Imaging studies in polycystic ovary syndrome / Sophie Jonard,Yann Robert, Yves Ardaens, and Didier Dewailly -- 5. Genes related to metabolic abnormalities or insulin resistance in polycystic ovary syndrome / Hector F. Escobar-Morreale -- 6. Anti-androgens / Kiirşad Ünlühizarci and Fahrettin Keleştimur -- 7. Lipid abnormalities in polycystic ovary syndrome / Djuro Macut -- 8. Serine phosphorylation, insulin resistance, and the regulation of androgen synthesis / Andrew A. Bremer and Walter L. Miller -- 9. Chronic treatment of polycystic ovary syndrome: oral contraceptive pills / Shahla Nader -- 10. Insulin-sensitizing drugs for the treatment of infertility in polycystic ovary syndrome / Cynthia S. Ryan and John E. Nestler -- 11. Diet and lifestyle factors in the etiology and management of polycystic ovary syndrome / R.J. Norman and L.J. Moran -- 12. Adrenarche: the interrelationship of androgens/insulin on the development of the metabolic syndrome/polycystic ovary syndrome / Sharon E. Oberfield, Natasha Leibel, Lauren Antler, Miriam Silfen, Lenore S. Levine, Mary Horlick, Goldy Carbunaru, Ximena Lopez, and Songya Pang -- 13. Cardiovascular disease and inflammation / Francesco Orio, Jr., Evanthia Diamanti-Kandarakis, and Stefano Palomba -- 14. Surgery and laser diathermy / Stefano Palomba, Fulvio Zullo, Evanthia Diamanti-Kandarakis, and Francesco Orio, Jr. -- 15. Late pregnancy complications in polycystic ovary syndrome / Dimitrios Panidis and Neoklis A. Georgopoulos -- 16. Glucose intolerance / Vincenzo Toscano -- 16. Hormonal and biochemical evaluation of polycystic ovary syndrome / Bulent O. Yildiz -- 18. Endometrial carcinoma in polycystic ovary syndrome / Emmanuel Diakomanolis -- 19. Statins, oxidative stress, and polycystic ovary syndrome / Pinar H. Kodaman and Antoni J. Duleba -- 20. Glucose intolerance in polycystic ovary syndrome: focus on the [beta]-cell / David A. Ehrmann -- 21. Polycystic ovary syndrome: definitions and epidemiology / Bart C.J.M. Fauser, Frank J. Broekmans, Joop S.E. Laven, Nick S. Macklon, and Basil Tarlatzis -- 22. Anovulation in polycystic ovary syndrome / Steven Franks -- 23. Nonalcoholic fatty liver disease in polycystic overy syndrome / WalterFutterweit -- 24. "Secondary" polycystic ovary syndrome / Gregory Kaltsas and George Chrousos -- 25. Long-term sequelae of polycystic ovary syndrome: association with insulin resistance and the metabolic syndrome / Richard S. Legro -- 26. The Insulin resistance of polycystic ovary syndrome / Marek Demissie, Richard S. Legro, and Andrea Dunaif -- 27. Therapeutic aspects of polycystic ovary syndrome in adolescence / George Mastorakos, Carolina Koliopoulos, and George Creatsas -- 28. Lifestyle intervention in polycystic ovarian syndrome / Onno E. Janssen, Susanne Tan, and Susanne Hahn -- 29. Involvement of the endocannabinoid system in metabolism and fertility: potential implication in the polycystic ovary syndrome / Uberto Pagotto, Alessandra Gambineri, Valentina Vicennati, and Renato Pasquali -- 30. Insulin resistance: definition and epidemiology in normal women and polycystic ovary syndrome women / Renato Pasquali and Alessandra Gambineri -- 31. Clinical evaluation of polycystic ovary syndrome / Ann E. Taylor -- 32. Pharmaceutical intervention in metabolic and cardiovascular risk factors in polycystic ovary syndrome / Evanthia Diamanti-Kandarakis -- 33. Insulin resistance and early pregnancy loss in polycystic ovary syndrome / Daniela Jakubowicz and Susmeeta T. Sharma.
  • Diabetes is extremely common, with approximately 171 million people affected worldwide. The majority of people with diabetes are cared for in primary care. Primary health care professionals are usually adept at dealing with the lifestyle measures and tablet treatments for diabetes, but generally have limited expertise in the initiation and management of insulin therapy. Insulin therapy has also become more complex, with numerous different forms of insulin and more complex delivery devices available. In a secondary care setting, approximately 10% of in-patients will have diabetes at any one time. People with diabetes stay in hospital longer than people without diabetes, and the condition is often poorly managed during in-patient stays, often leading to clinical errors. Insulin Therapy: A Pocket Guide provides clear and concise information about the safe prescribing of insulin both subcutaneously and intravenously. It covers the different types of insulin, the delivery devices, side effects of insulin and, most importantly, guidance on rational dose adjustment.This book is an invaluable guide for general practitioners and primary care nurses with a special interest in diabetes, as well as junior hospital doctors and specialist medical trainees, advanced nurse practitioners and new diabetes nurse specialists.
  • Surgery of the Pancreatic Carcinoma -- Basic Chapter / René Mantke, Hans Lippert -- Commentary / Claudio Bassi, Giovanni Butturini, Roberto Salvia -- Commentary / Thilo Hackert, Jens Werner, Markus W. Büchler -- Commentary / Philippe Bachellier, E. Rosso, D. Jaeck -- Commentary / Michael G. T. Raraty, John P. Neoptolemos -- Commentary / Tadahiro Takada, Keita Wada, Keiji Sano -- Commentary / Andrew L. Warshaw -- Chronic Pancreatitis Surgery -- Basic Chapter / Hans-Ulrich Schulz, René Mantke, Hans Lippert -- Commentary / David B. Adams, Katherine A. Morgan -- Commentary / P. C. Bornman -- Commentary / Thilo Hackert, Markus W. Büchler -- Commentary / Michael B. Farnell, Ashleigh L. Levendale -- Commentary / A. Fingerhut, S. V. Shrikhande, P. J. Shukla -- Commentary / Michael G. T. Raraty, John P. Neoptolemos -- Cystic Neoplasms of the Pancreas: SCN, MCN, IPMN -- Basic Chapter / Thilo Hackert, Stefan Fritz, Markus W. Büchler -- Commentary / Katherine A. Morgan, David B. Adams -- Commentary / Roberto Salvia, Marco Dal Molin, Claudio Bassi -- Commentary / C. Max Schmidt -- Commentary / Masao Tanaka -- Surgery of Acute Pancreatitis -- Basic Chapter / René Mantke, Hans-Ulrich Schulz, Hans Lippert -- Commentary / Hans G. Beger, B. M. Rau, B. Poch -- Commentary / Peter Fagenholz, Carlos Fernández-del Castillo -- Commentary / H. G. Gooszen -- Commentary / C. W. Imrie, C. R. Carter -- Commentary / Åke Andrén-Sandberg -- Commentary / Michael G. Sarr.
  • Molecular characterization and phenotypic expression of mutations in genes for gonadotropins and their receptors in humans / Salvi, R., Pralong, F.P -- Role of kisspeptin/GPR54 system in human reproductive axis / Silveira, L.F.G. ... [et al.] -- Biology of kisspeptins / Hameed, S., Dhillo, W.S. -- Role of fibroblast growth factor signaling in gonadotropin-releasing hormone neuronal system development / Chung, W.C.J., Tsai, P.-S. -- FGFR1 mutations in Kallmann syndrome / Villanueva, C., de Roux, N. -- Biology of KAL1 and its orthologs : implications for x-linked Kallmann syndrome and the search for novel candidate genes / MacColl, G.S., Quinton, R., Bülow, H.E. -- Biological actions and interactions of anosmin-1 / Choy, C., Kim, S.H. -- Genotype and phenotype of patients with gonadotropin-releasing hormone receptor mutations / Kim, H.-G. ... [et al.] -- Hypogonadotropic hypogonadism and GNRH1 mutations in mice and humans / Bouligand, J. ... [et al.] -- Kallmann syndrome caused by mutations in the PROK2 and PROKR2 genes : pathophysiology and genotype-phenotype correlations / Sarfati, J., Dodé, C., Young, J. -- Neurokinin B and its receptor in hypogonadotropic hypogonadism / Semple, R.K., Topaloglu, A.K. -- Complex genetics in idiopathic hypogonadotropic hypogonadism / Pitteloud, N. ... [et al.] -- Rarer syndromes characterized by hypogonadotropic hypogonadism / Aminzadeh, M. ... [et al.].
  • Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.
  • Leptin 2006
  • Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
  • This book pursues a multidisciplinary approach, presenting chapters with updated information on various aspects of treatment for patients with neuroendocrine tumors. Authors have been selected from expert centers in Europe and the United States. The goal of this book is to comprehensively summarize recent data and provide inspiring ideas to optimize the care of patients with neuroendocrine tumors. Neuroendocrine tumors are fascinating multifaceted diseases that can primarily localize in many organs with various presentations. These tumors are rare but their increasing incidence renders likely that physicians caring for cancers may have either already faced or may be certainly exposed to diagnose and/or treat a patient with neuroendocrine tumors. Over the last years, novel therapeutic options have emerged for neuroendocrine tumors, profoundly challenging practices that had previously been the standards for decades. These include - but are not limited to - somatostatin analogues, targeted therapies such as tyrosine kinase and mTOR inhibitors, antiangiogenic compounds, but also peptide-receptor targeted therapy or radioembolization. This changing field has generated novel treatment algorithms to guide medical decisions. To better understand and handle the multidisciplinary approaches that are required for optimizing the care of neuroendocrine tumor patients, physicians are now looking for references from experts and comprehensive reviews summarizing current knowledge on treatments for patients with neuroendocrine tumors.
  • This book provides the reader with a multidisciplinary approach that is state of the art and reflects input from the European Neuroendocrine Tumor Society and the North American Neuroendocrine Tumor Society. In particular, the text focuses on the pathophysiology of neuroendocrine tumors and includes a comprehensive review of the most recent developments in understanding the complex hormone and receptor signaling that is important for the future development of potent pharmacological treatments. The volume reviews the pathological grading and staging systems providing useful clinical information for the treating clinician as well as a useful reference for pathologists. The clinical management of neuroendocrine tumors is reviewed enabling the treating physician to understand the diagnostic approaches to differentiating the various types of neuroendocrine tumors. In addition, the treatments are reviewed in great detail and include novel radiological, surgical, and chemotherapeutic approaches. The reader will utilize this book as both a comprehensive and quick reference guide through the use of diagnostic and treatment algorithms. Written by international experts in their particular field of study, Management of Pancreatic Neuroendocrine Tumors will be of great value to medical oncologists, endocrinologists, gastroenterologists, pathologists, surgeons, and diagnostic and interventional radiologists.
  • Molecular risk stratification of well-differentiated thyroid cancer -- The significance of cervical lymph nodes in well-differentiated thyroid cancer -- Management of the central compartment in well-differentiated thyroid carcinoma -- Management of the lateral neck in well-differentiated thyroid cancer -- The management of recurrent/persistent well-differentiated thyroid cancer in the central compartment -- Management of distant metastases in differentiated thyroid cancer -- Risk-adjusted strategies in post-treatment surveillance of well-differentiated thyroid carcinoma -- Medullary thyroid cancer -- Anaplastic thyroid cancer: Current concepts -- External beam radiotherapy for thyroid cancer -- Targeted therapies in thyroid cancer.
  • Managing diabetes 2012
    Managing Diabetes is a up-to-date, comprehensive showcase of the current pharmaceutical trends in treating diabetes and provides a unbiased, inclusive discussion of current and emerging treatments by well-known experts in the field.
  • 1. Thyroid nodule -- 2. Goiter -- 3. Hyperthyroidism --4. Papillary thyroid carcinoma -- 5. Follicular thyroid carcinoma and oncocytic (Hürthle cell) carcinoma -- 6. Medullary thyroid carcinoma -- 7. Anaplastic thyroid carcinoma, metastases to the thyroid gland, and thyroid lymphoma -- 8. Primary hyperparathyroidism -- 9. Persistent and recurrent hyperparathyroidism -- 10. Secondary and tertiary hyperparathyroidism -- 11. Parathyroid Carcinoma -- 12. Incidentalomas and metastases to the adrenal gland -- 13. Hyperaldosteronism -- 14. Hypercortisolism -- 15. Pheochromocytoma and paraganglioma -- 16. Adrenocortical carcinoma -- 17. Insulinoma -- 18. Gastrinoma -- 19. Carcinoid tumors -- 20. Other functional and nonfunctional neuroendocrine tumors -- 21. Multiple endocrine neoplasia Ttype 1 -- 22. Multiple endocrine neoplasia type 2 -- 23. von Hippel-Lindau disease.
  • Introduction -- Etiopathogenesis -- Clinical Features -- Psychological implications of PCOS -- Diagnosis and Assessment -- PCOS Therapy.
  • Part 1. Metabolic Syndrome - Past and Future -- Metabolic Syndrome - Past and Future : An Introduction to the Features of This Book / Barbara Caleen Hansen, Rosemary Peternel and George A. Bray -- I. Epidemiology And Clinical Treatment: Issues In Defining And Treating The Metabolic Syndrome -- Metabolic Syndrome : To Be or Not to Be? / Gerald M. Reaven -- The Role of Obesity in Insulin Resistance : Epidemiological and Metabolic Aspects / James B. Meigs -- Treatment of the Metabolic Syndrome with Weight Loss, Exercise, Hormones, and Surgery / George A. Bray -- Insulin Resistance, Metabolic Syndrome, and Cardiovascular Disease : An Epidemiological Perspective / Earl S. Ford and Simin Liu -- The Sympatho-Adrenal System in the Metabolic Syndrome / Lewis Landsberg -- II. Endothelial Function, Inflammation, and Dyslipidemia -- Insulin Action and Endothelial Function / Kieren J. Mather, Alain Baron and Michael J. Quon -- Macro- and Microvascular Disease in an Insulin-Resistant Pre-Diabetic Animal Model : The JCR:LA-cp Rat / James C. Russell and Spencer D. Proctor -- High-Sensitivity C-Reactive Protein and the Metabolic Syndrome / Yiqing Song, Simin Liu and Joann E. Manson -- Insulin Signaling in Adipocytes and the Role of Inflammation / Christian X. Andersson, Ann Hammarstedt, Per-Anders Jansson and Ulf Smith -- Insulin Resistance and Dyslipidemia / Tina J. Chahil, Gissette Reyes and Henry N. Ginsberg -- III. Insulin - Secretion and Action: Underlying Mechanisms of the Metabolic Syndrome -- Pancreatic Islet Pathophysiology and Pathology in Obesity / Anne Clark, Jenni Moffitt, Lianne Van De Laar, Katherine Pinnick and Farhina Sayyed -- Glucagon-like Peptides and Insulin Sensitivity / Jens Juul Holst and Filip Krag Knop -- The Relationship Between the Insulin Receptor Substrates and Metabolic Disease / Morris F. White -- Insulin Resistance and Inhibitors of the Insulin Receptor Tyrosine Kinase / Jack F. Youngren -- Fat Feeding and Muscle Fat Deposition Eliciting Insulin Resistance : An Update / E. W. Kraegen, G. J. Cooney, Jiming M. Ye and Stuart M. Furler -- Alterations in Atypical Protein Kinase C Activation in Insulin Resistance Syndromes / Robert V. Farese -- The Liver, Glucose Homeostasis, and Insulin Action in Type 2 Diabetes Mellitus / Jerry Radziuk and Susan Pye -- Chronomics of the Metabolic Syndrome / Barbara Caleen Hansen.
  • Corticosteroids and related drugs -- Prostaglandins -- Sex hormones and related drugs -- Iodine and drugs that affect thyroid function -- Insulins and other hypoglycemic drugs -- Other hormones and related drugs -- Lipid-regulating drugs -- Endocrine and metabolic adverse effects of non-hormonal and non-metabolic drugs.
  • "The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host ("us"). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease"--Publisher's description.
  • "Minimally Invasive and Robotic Thyroid and Parathyroid Surgery is the first textbook which includes a comprehensive review of both minimally invasive and robotic thyroid and parathyroid techniques. Over the last several years there has been a rapid expansion in the number of different surgical approaches available to patients undergoing thyroid and parathyroid surgery. This book consolidates these in one source and focuses on both the philosophy and techniques of these procedures. For thyroid surgery, the text covers the full range of minimally invasive procedures and several of the most widely adopted remote access techniques. Several related procedures are also discussed, including minimally invasive approaches to central and lateral neck dissection. For parathyroid surgery, several minimally invasive techniques are covered, including radioguided surgery. Written by experts in the field of thyroid and parathyroid surgery, Minimally Invasive and Robotic Thyroid and Parathyroid Surgery serves as a critical resource for both experienced and less experience surgeons, fellows, residents, and students interested in understanding the breadth of this field or learning the specific steps of a particular technique."--Publisher's website.
  • This book describes in detail the various techniques of minimally invasive thyroidectomy that have emerged in recent years and presents the new supportive equipment, including intraoperative monitoring and energy devices. In addition, the basic preoperative techniques that are a prerequisite to successful thyroidectomy are covered, and individual chapters are devoted to complications, outcomes, and post-thyroidectomy quality of life. Important related topics are also discussed, including guidelines for managing papillary and medullary thyroid cancer and the surgical management of metastatic lymph nodes. Both the editors and the authors are internationally renowned experts, and they include the founders of several of the techniques described. The up-to-date text is supplemented by many color pictures and medical illustrations, making the book very user-friendly and ideal for the busy surgeon or endocrinologist who is interested in the management of thyroid diseases.
  • Molecular oncogenesis -- Systematic autoimmune diseases -- MicroRNAs in endocrine diseases -- Clinical detection and treatment of thyroid diseases -- Autoimmune thyroid diseases -- Benign nodular thyroid disease -- Fine needle aspiration: present and future -- Well-differentiated papillary thyroid carcinoma -- Well-differentiated thyroid follicular carcinoma -- Poorly differentiated and undifferentiated thyroid carcinomas -- Medullary thyroid carcinoma -- Unusual thyroid tumors -- Hematopoietic tumors of the thyroid -- Clinical detection and treatment of parathyroid diseases -- Nonneoplastic parathyroid diseases -- Neoplastic parathyroid diseases -- Clinical detection and treatment of benign and malignant pituitary diseases -- Nonneoplastic and neoplastic pituitary diseases -- Clinical detection and treatment of adrenal disease -- Benign and malignant pheochromocytomas and paragangliomas -- Benign and malignant diseases of the adrenal cortex -- Clinical detection and treatment of pancreatic neuroendocrine tumors -- Pancreatic endocrine neoplasms -- Gastrointestinal neuroendocrine tumors -- Head and neck neuroendocrine tumors -- Merkel cell carcinoma -- Neuroendocrine lung tumors.
  • Historical perspective on the genetic forms of congenital hyperinsulinism / Stanley, C.A., Matschinsky, F.M. -- Biochemistry and physiology of the ATP-sensitive potassium channel / Remedi, M.S., Nichols, C.G. -- Pathophysiology of diffuse ATP-sensitive potassium hyperinsulinism / De León, D.D., Stanley, C.A. -- Molecular defects of ATP-sensitive potassium channels in congenital hyperinsulinism / Shyng, S.-L. ... [et al.] -- Molecular mechanisms and clinical pathophysiologies of focal ATP-sensitive potassium hyperinsulinism and Beckwith-Wiedemann Syndrome / Arnoux, J.-B. ... [et al.] -- Pancreatic histopathology of hyperinsulinism / Suchi, M., Bhatti, T.R., Ruchelli, E.D. -- Localization of a focal lesion of congenital hyperinsulinism : imaging and surgery / States, L.J., Adzick, N.S. -- Role of incretin hormones in hyperinsulinemic hypoglycemia / De León, D.D. -- Glutamate dehydrogenase : structure, regulation, and its role in insulin homeostasis / Smith, T.J. -- Congenital hyperinsulinism due to activating mutations of glutamate dehydrogenase : the hyperinsulinism/hyperammonemia syndrome / Kelly, A., Palladino, A., Stanley, C.A. -- Amino acid-stimulated insulin secretion : the role of the glutamine-glutamate-alpha-ketoglutarate axis / Li, C., Matschinsky, F.M., Stanley, C.A. -- Tissue specificity of glutamate dehydrogenase as illustrated in pancreatic beta-cells and the central nervous system / Carobbio, S. ... [et al.] -- The molecular genetics and pathophysiology of congenital hyperinsulinism caused by short-chain 3-hydroxyacyl-CoA dehydrogenase deficiency / Molven, A. ... [et al.] -- Hyperinsulinism due to activating mutations of glucokinase / Sayed, S., Matschinsky, F., Stanley, C.A. -- Hyperinsulinism due to mutations of uncoupling protein 2 / Del Mar Gonzalez-Barroso, M., de Lonlay, P., Ricquier, D. -- Exercise-induced hyperinsulinism : a failure of monocarboxylate transporter 1 expression silencing / Otonkoski, T., Meissner, T. -- HNF4A and hyperinsulinemic hypoglycemia / Kapoor, R.R., James, C.T., Hussain, K.
  • Neuroendocrine effects of developmental PCB exposure, with particular reference to hypothalamic gene expression -- The kisspeptin system as putative target for endocrine disruption of puberty and reproductive health -- Effects of prenatal exposure to endocrine disrupters on cerebral cortex development -- Endocrine disruption of the thyroid and its consequences in development -- Neural progenitors are direct targets of xenoestrogens in zebrafish -- Exposure to environmental chemicals as a risk factor for diabetes development -- Contribution of endocrine disrupting chemicals to the obesity epidemic: consequences of developmental exposure -- Fetal and adult exposure to bisphenol-A as a contributing factor in the etiology of the metabolic syndrome -- Bisphenol A in the gut: another break in the wall? -- Adverse trends of male reproductive health in two nordic countries indicate environmental problems -- Origin of testicular dysgenesis syndrome disorders in the masculinization programming window: relevance to final testis size (=sperm production) -- Index.
  • This book describes in detail the multidisciplinary management of obesity, providing readers with a thorough understanding of the rationale for a multidisciplinary approach and with the tools required to implement it effectively. The emphasis is on a translational approach, starting from basic concepts and fundamental mechanisms of the pathology and clinical morbidity. Experts in the field discuss the full range of relevant topics, including the significance of physical exercise, psychological issues, nutritional strategies, pharmacological options, and bariatric surgery. Put another way, the book covers all aspects from the bench to the bedside. Physicians, scientists, and postgraduate students will all find it to be invaluable in understanding the causes and optimal management of obesity, which has rapidly become a major public health problem.
  • In theoretical terms, sex differences in brain and behavior offer the possibility of fascinating scientific studies on a range of molecular phenomena such as DNA methylation, chromatin protein modification, non-coding DNA, resulting in important neuroanatomical and neurochemical effects. However, this general subject has been treated with much hyperbole. Historically, sex differences were assumed to be present where they did not really exist, e.g. with respect to mathematics, executive leadership, etc. etc. Under what circumstances do we really care about sex differences in brain and behavior? These circumstances concern human maladies whose diagnoses are much different between boys and girls, or between women and men. Prominent examples to be discussed today will include autism, attention deficit hyperactivity disorders and congenital adrenal hyperplasia. The meeting will end with a consideration of effects of estrogenic hormones on the injured brain, and their roles as protective agents.
  • Muscle metabolism 2002
    Perspectives / Eleazar Shafrir -- I. Insulin Signaling -- 1. Overview: Tyrosine Kinase Signaling in Insulin Action / Martin G. Myers, Jr. -- 2. Defects in Early Insulin Signaling in Skeletal Muscle / M. Dodson Michael and C. Ronald Kahn -- 3. Defects in Intermediate Insulin Signaling in Skeletal Muscle: Phosphatidylinositol (PI) 3-kinase and Glucose Transport / Francesco Giorgino -- II. Glucose Transport -- 4. Glucose Transport in Muscle / John O. Holloszy and Lorraine A. Nolte -- 5. The GLUT4 Compartments of Skeletal Muscle / Toolsie Ramlal, Peter Tong, Tony Lam, Romel Somwar, Maureen Charron and Amira Klip -- III. Substrate Utilization -- 6. Adverse Metabolic Consequences of Hyperglycemia ("Glucose Toxicity"): Implications for the Pathogenesis of Diabetes Mellitus / Donald A. McClain -- 7. Cellular Mediators of Glucose-Induced Autoregulation of Hexose Transport / Evgenia Alpert, Hanan Totary and Shlomo Sasson -- 8. Physiological Adaptations in Glucose Utilization of Skeletal Muscle / Julian M.R. Mathoo and Mladen Vranic -- 9. Fatty Acids and Muscle Insulin Resistance / Edward W. Kraegen, Gregory J. Cooney, Jiming Ye, Alison L. Thompson and Stuart M. Furler -- 10. Role of AMP Kinase and Malonyl CoA in Exercise-stimulated Skeletal Muscle Metabolism and Insulin Action / David J. Dean and Neil B. Ruderman -- IV. Transgenic and Genetic Models -- 11. The Use of Mouse Transgenic and Homologous Recombination.
  • Section 1. Pituitary and hypothalamus -- section 2. Thyroid -- section 3. Adrenal -- section 4. Reproduction -- section 5. Pancreas -- section 6. Bone and calcium -- section 7. Lipids and nutrition -- section 8. Genetics and endocrine neoplasia.
  • Deals with endocrine regulation of the behavioral state control. This title addresses a wide spectrum of sleep/wakefulness phenomena (both animals and humans), including pathogenesis, diagnosis, and management. It provides a summary of important issues in the neuroendocrine correlates of sleep/wakefulness.
  • Global epidemiology of neuroendocrine tumors -- Pathology -- Multiple endocrine neoplasia -- Other genetic syndromes -- Imaging of neuroendocrine tumors -- Surgical management of sporadic gastrointestinal neuroendocrine tumors -- Management of neuroendocrine tumor hormonal syndromes -- Management of metastatic carcinoid tumors -- Medical management of islet cell carcinoma -- Poorly differentiated neuroendocrine tumors -- Hereditary and sporadic medullary thyroid carcinoma -- Adrenocortical carcinoma -- Pheochromocytoma -- Merkel cell carcinoma.
  • Epidemiology of neuroendocrine tumors / Fraenkel, M.; Faggiano, A. ; Valk, G.D. -- Biochemical testing in patients with neuroendocrine tumors / Granberg, D. -- Clinical syndromes related to gastrointestinal neuroendocrine neoplasms / Boutzios, G.; Kaltsas, G. -- Radiological imaging : computed tomography, magnetic resonance imaging and ultrasonography / Sundin, A.; Wills, M.; Rockall, A. -- Nuclear medicine imaging of neuroendocrine tumors / Brabander, T.; Kwekkeboom, D.J.; Feelders, R.A.; Brouwers, A.H.; Teunissen, J.J.M. -- Endoscopy and endoscopic ultrasound in assessing and managing neuroendocrine neoplasms / O'Toole, D.; Palazzo, L -- Pathology : classification and immunoprofile / Blank, A.; Schmitt, A.; Perren, A. -- Genetics and epigenetics of pancreatic neuroendocrine tumors and pulmonary carcinoids / Dreijerink, K.M.A.; Derks, J.L.; Cataldo, I.; Scarpa, A.; Valk, G.D.; Speel, E.-J.M. -- Pancreatic surgery / Maurizi, A.; Partelli, S.; Falconi, M. -- Gastrointestinal surgery of neuroendocrine neoplasms / Palns Hansen, C.; Holst Olsen, I.; Knigge, U. -- Transplantation and debulking procedures for neuroendocrine tumors / Frilling, A.; Al-Nahhas, A.; Clift, A.K. -- A 25-year experience of gastroenteropancreatic neuroendocrine tumors and somatostatin (congeners) analogs : from symptom control to antineoplastic therapy / O'Dorisio, T.M. ; Anthony, L.B. -- Medical therapy of pulmonary neuroendocrine neoplasms : targeted, symptomatic and chemotherapy / Ferolla, P. -- Peptide receptor radionuclide therapy of neuroendocrine tumors / Bodei, L.; Kidd, M.; Prasad, V.; Modlin, I.M. -- Hormone and receptor candidates for target and biotherapy of neuroendocrine tumors / Hofland, L.J.; Vandamme, T.; Albertelli, M.; Ferone, D. -- The role of chemotherapy in well-differentiated gastroenteropancreatic neuroendocrine tumors / Strosberg, J.; Goldman, J.; Costa, F.; Pavel, M. -- Other novel therapies : biomarkers, microRNAs and microRNA inhibitors, DNA methylation, epigenetics, immunotherapy and virotherapy / Giandomenico, V.; Thirlwell, C.; Essand, M.
  • Glucocorticoid-induced apoptosis of healthy and malignant lymphocytes / L.K. Smith, J.A. Cidloski.-- Impact of the hypothalamic-pituitary-adrenal/gonadal axes on trajectory of age-related cognitive decline / C.D. Conrad, H.A. Biomonte-Nelson.-- Menopause and mitochondria: windows into estrogen effects on Alzheimer's disease risk and therapy / V.W. Henderson, R. Diaz Brinton.-- DHEA, important source of sex steroids in men and even more in women / F. Labrie.-- Neuroendocrinology of post-traumatic stress disorder / P. Pervanidou, G.P. Chrousos.-- Assisted reproduction and its neuroendocrine impact on the offspring / C. Kanaka-Gantenbein, S. Sakka, G.P. Chrousos.-- Sex hormone and neuroendocrine aspects of the metobolic syndrome / H. Nawata, T. Watanabe, T. Yanase, M. Nomura, K. Ashida, L. Min, W. Fan.-- Ghrelin's role as a major regulator of appetitie and its other functions in neuroendocrinology / C.T. Lim, B. Kola, M. Korbonits, A.B. Grossman.-- Pathogenesis of pituitary tumors / R. Yu, S. Melmed.-- Molecular genetics of the AIP gene in familial pituitary tumorigenesis / A. Tahir, H.S. Chahal, M. Korbonits.-- Somatostatin and somatostatin receptors: from basic concepts to clinical applications / M.C. De Martino. J.J. Hofland, S.W.J. Lamberts.-- Somatostatin analogues: treatment of pituitary and neuroendocrine tumors / A. Colao, A. Faggiano, R. Pivonello.-- The MENX syndrome and p27: relationships with multiple endocrine neoplasia / S. Molatore, N.S. Pellegata.-- Hormonal therapy of prostate cancer / F. Labrie.-- Pheochromocytoma and paraganglioma / V. Kantorovich, K. Pacak.
  • ch. 1. Cellular signalling : peptide hormones and growth factors / Barry I. Posner and Stephane A. Laporte -- ch. 2. Neuroendocrine control of energy homeostasis : update on new insights / Satya P. Kalra and Pushpa S. Kalra -- ch. 3. Reproductive behaviors : new developments in concepts and in molecular mechanisms / Zachary M. Weil, Gen Murakami and Donald W. Pfaff -- ch. 4. Interactions betwen the immune and neuroendocrine systems / Serge Rivest -- ch. 5. Physiological roles of the kisspeptin/GPR54 system in the neuroendocrine control of reproduction / Rafael Pineda, ... [et al.] -- ch. 6. Regulation of complex pulsatile and rhythmic neuroendocrine systems : the male gonadal axis as a prototype / Johannes D. Veldhuis, Daniel M. Keenan and Steven M. Pincus -- ch. 7. Physiological significance of the rhythmic section of hypothalamic and pituitary hormones / Earn-Hui Gan and Richard Quinton -- ch. 8. Melatonin : a multitasking molecule / Russel J. Reiter, Dun-Xian Tan and Lorena Fuentes-Broto -- ch. 9. Modulation of steroid hormone receptor activity / Vladimir Stanišić, David M. Lonard and Bert W. O'Malley -- ch. 10. The intracrine sex steroid biosynthesis pathways / Van Luu-The and Fernand Labrie -- ch. 11. Steroidogenic enzymes in the brain : morphological aspects / Georges Pelletier -- ch. 12. The multiple roles of estrogens and the enzyme aromatase / Wah Chin Boon, Jenny D. Y. Chow and Evan R. Simpson -- ch. 13. ER[beta] in CNS : new roles in development and function / Xiaotang Fan, ... [et al.] -- ch. 14. Interactions of estradiol and insulin-like growth factor-I signalling in the nervous system : new advances / Luis M. Garcia-Segura, María-Angeles Arévalo and Iñigo Azcoitia -- ch. 15. A hormonal contraceptive for men : how close are we? / Ilpo Huhtaniemi.
  • While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychological conditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
  • Transcription factor genes in type 2 diabetes / by M.N. Weedon, A.T. Hattersley & T.M. Frayling -- PPAR[gamma], a key therapeutic target in the metabolic syndrome-unique insights derived from the study of human genetic variants / by C.S. Mitchell & M. Gurnell -- PPAR[delta]: emerging therapeutic potential of novel agonists in lipid and glucose homeostasis / by U. Dressel & G.E.O. Muscat -- Liver X receptors as potential drug targets for diabetes and its disorders / by K.R. Steffenson -- SREBP-lc regulation of nutrient homeostasis and lipid accumulation / by P. Ferré ... [et al.] -- The adipocyte and adipose tissue as endocrine organs: impact on the insulin resistance phenotype / by R.R. Henry ... [et al.] -- FOXC2 in the adipocyte / by S. Enerbäck -- Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors / by I. Gerin, H.D. Cha & O.A. MacDougald -- GATA proteins as molecular gatekeepers of adipogenesis / by J. Tsai, Q. Tong & G.S. Hotamisligil -- Forkhead proteins and the regulation of hepatic gene expression / by A. Barthel, S. Herzig & D. Schmoll -- Disruption of CREB regulated of gene expression in diabetes / by J.E.B. Reusch, P.A. Watson & S. Pugazhenthi -- Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: functional implications / by J. Pihlajamäki & M.E. Patti -- Hepatic CCAAT/enhancer binding protein [beta] (C/EBP[beta]): engineer of diabetes, obesity, and inflammatory disease processes / by J.M. Schroeder-Gloeckler, S.M. Rahman & J.E. Friedman -- Insulin resistance, inflammation, and the IKK/I[kappa]B/NF-[kappa]B pathway by B.A. Bhatt & R.M. O'Doherty.
  • Pathological Alteration of Human Adipose Tissue in Obesity / Karine Clément -- Dynamics of Human Adipose Tissue. Regulatory Mechanisms and Consequences for Fat Cells and the Whole Body / Peter Arner -- Metabolism of Fatty Acids in Adipocytes / A. L. Dinel, C. Kolditz and D. Langin -- The Role of Hypoxia in Adipocyte Function and Dysfunction / Paul Trayhurn, Fátima Pérez de Heredia, Bohan Wang and I. Stuart Wood -- Brown Adipose Tissue In Humans: A New Target for Anti-Obesity Therapy / Sven Enerbäck -- Adipose Tissue Dysfunction: A Multistep Process / Kai Sun and Philipp E. Scherer -- Fat Cell Progenitors: Origins and Plasticity / Christian Dani -- Transcriptional Regulation of Brown and White Adipogenesis / Bruce M. Spiegelman -- Transcriptional Control of Gene Expression in Different Adipose Tissue Depots / Stephen R. Farmer -- Epigenetic Approaches to Adipose Biology / Evan D. Rosen -- Metabolic and Angiogenic Consequences of the Presence or Absence of UCP1 / Barbara Cannon and Jan Nedergaard -- Metabolic Responses to Weight Perturbation / Rudolph L. Leibel and Michael Rosenbaum -- Understanding Causal Relationships in the Metabolic Syndrome: Recent Insights from Extreme Human Phenotypes / David B. Savage.
  • Nuclear medicine is an important element of daily practice for the endocrinologist, both for diagnosis and for treatment. The continuous rapid development of nuclear medicine procedures has created the need for a concise, up-to-date practical guide that presents the essential information required by the endocrinologist. This book is designed to ensure ease of use in clinical practice and provides the most relevant information on nuclear medicine as applied to endocrine pathology. It is divided into three sections covering general aspects of nuclear medicine, the role of nuclear endocrinology in diagnosis, and the role of nuclear endocrinology in therapy. The endocrine glands are covered by organ and by pathology. Pertinent background information is provided, choice of radiopharmaceutical is explained, and the role of different image acquisition techniques is discussed. In addition, informative clinical cases are presented with the aid of high-quality images.
  • "Focusing on the worldwide impact of type 2 diabetes regarding nutrition, dietary modification, risk, and management, this book draws on evidence-based research and provides numerous epidemiologic cohort studies, as well as carefully conducted clinical trials. Chapters correlate treatment modes and risk factors as well as the global impact of nutrition back to the basic premise held in the etiology of the disease. Topics include historical perspectives; macronutrients, micronutrients, food, dietary beverages, and dietary patterns; diet-gene interactions; and the role of age, ethnicity, and other demographics in modifying treatment for type 2 diabetes"--Provided by publisher.
  • This timely and clinically oriented book uniquely addresses the entire spectrum of treatment for severe obesity and diabetes. It thoroughly examines all aspects from robotic surgery to cell therapy, from the latest antidiabetic drugs to endoscopic procedures and devices, from appetite-inhibiting signals and nutrients to gastric arterial embolization. It offers objective and authoritative information for practicing professionals; not only are successful interventions discussed and updated, but cutting-edge and experimental pathways are also anticipated. Obesity is the foremost nutritional challenge worldwide. Its companion is type-2 diabetes, the most prevalent metabolic disease. Together they represent the diabesity epidemic, which is draining resources, overwhelming healthcare facilities, and impacting life expectancy and quality of life everywhere. No country has been spared, and most medical specialties have been affected. Many books focus on the surgical options for obesity and diabetes, namely bariatric and metabolic operations. Information on the clinical and pharmacological treatment is also available, conveyed by standard texts on internal medicine and endocrinology. Yet endoscopic maneuvers and prostheses, cell therapy for diabetes, and other innovative approaches are hard to come by, as conventional texts overlook such therapies. This timely publication bridges the gaps between all different therapeutic options, also covering advances in the conservative, surgical and parasurgical domains. This book will appeal to seasoned specialists, students and healthcare professionals in training alike.
  • Monogenic human obesity / Farooqi, I.S. -- Polygenic contribution to obesity : genome-wide strategies reveal new targets / Korner, A. ... [et al.] -- Genetic obesity syndromes / Goldstone, A.P., Beales, P.L. -- Fetal and neonatal pathways to obesity / Gluckman, P.D. ... [et al.] -- Developmental origins of obesity and the metabolic syndrome : the role of maternal obesity / Armitage, J.A., Poston, L., Taylor, P.D. -- Childhood obesity / Sabin, M.A., Shield, J.P.H. -- Obesity in old age / McPhee Chapman, I. -- Models of obesity in large animals and birds / Clarke, I.J. -- The [beta]-cell in type 2 diabetes and in obesity / Rutter, G.A., Parton, L.E. -- Role of the endocannabinoid system in energy balance regulation and obesity / Cota, D. -- 11[beta]-hydroxysteroid dehydrogenase type 1 and obesity / Morton, N.M., Seckl, J.R. -- Gut and hormones and obesity / Wren, A.M. -- Adipokines in obesity / Ahima, R.S., Osei, S.Y. -- The role of AMP-activated protein kinase in obesity / Kola, B., Grossman, A.B., Korbonits, M. -- Classical endocrine diseases causing obesity / Weaver, J.U. -- Emerging concepts in the medical and surgical treatment of obesity / Aylwin, S., Al-Zaman, Y. -- The sociology of obesity / Rosengren, A., Lissner, L. -- Obesity in art--a brief overview / Woodhouse, R.
  • In addition to their metabolic and endocrinologic effects, obesity and adipose tissue have now been shown to be associated with chronic low grade inflammation resulting in cellular and humoral factors of which the latter may act by endocrine, paracrine and autocrine mechanisms. These inflammatory mediators have increasingly been suggested as contributing to the obesity link to carcinogenesis and cancer promotion. Obesity, Inflammation and Cancer focuses on recent developments and cutting edge research pointing to inflammation and inflammatory factors as key mediators of this linkage. It also describes possible strategies for targeting inflammation as an approach to cancer prevention and control. Students, researchers and clinicians, especially those interested in the relation of obesity to cancer and the role of inflammation and its impact on cancer, will find this volume particularly useful. It provides important insight on the role of inflammation in cancer etiology and progression and serve as a platform for developing future research in this area.
  • Office andrology 2005
    Essentials of sperm biology / Sharon T. Mortimer -- Endocrinology of male infertility / R. Dale McClure -- Sperm preparation for insemination / Grace M. Centola -- Specialized sperm testing: pros and cons / Kirk C. Lo ... [et al.] -- Genetic testing for male infertility / Robert D. Oates -- Optimizing success in a donor insemination program / Phillip E. Patton -- Ethical and legal considerations of donor insemination in the United States / Karen E. Adams -- Laboratory accreditation / William Byrd -- Office evaluation of male infertility / Darius A. Paduch and Eugene F. Fuchs -- Varicocele and infertility / Ulrike Zenke and Paul Turek -- Strategic therapies for ejaculatory disorders and erectile dysfunction in the infertile man / Mustafa F. Usta and Wayne J. G. Hellstrom -- Vasectomy reversal / Eugene F. Fuchs and Darius A. Paduch -- Infection and male infertility / Emmett F. Branigan -- Obstructive and nonobstructive azoospermia / Kinloch Nelson and Peter Schlegel -- Testis biopsy and the infertile male / Sherman J. Silber -- Intracytoplasmic sperm injection: the process, the outcomes, and the controversies / David E. Battaglia -- Treatment of human immunodeficiency virus-discordant couples / Joseph E. Peña and Mark V. Sauer -- Sperm and egg retrieval for posthumous reproduction: practical, ethical, and legal considerations / Lisa V. Brock and Anna C. Mastroianni -- Gender selection: separating fact from fiction / David S. Karabinus and Keith L. Blauer.
  • Print Material
  • The second edition of this highly successful book updates the reader on progress and developments in the field of ovulation induction and controlled ovarian stimulation. Furthermore, it provides the busy clinician with a reliable overview of the principles involved and the management needed. As with the previous edition, the emphasis throughout this book is on logical evidence and evidence-based solutions, supplemented with Professor Roy Homburgs extensive clinical experience gleaned from more than forty years working in the field. A number of highly useful algorithms and explanatory tables reinforce this approach, ensuring that the reader is presented with easy-to-grasp, well-presented information that maximizes clarity and understanding. Ovulation Induction and Controlled Ovarian Stimulation: A Practical Guide offers a concise, no-nonsense, practical guide to ovulation induction and controlled ovarian stimulation and will be an essential resource for general gynaecologists, fertility specialists and trainees, health workers and students.
  • Evolution, child development and the thyroid : a phylogenetic and ontogenetic introduction to normal thyroid function / Krude, H. -- Human fetal thyroid function / Polak, M. -- The role of thyroid hormones for brain development and cognitive function / Rovet, J. F. -- Neonatal screening for congenital hypothyroidism / Torresani, T. -- Diagnosis, treatment and outcome of congenital hypothyroidism / Van Vliet, G.; Deladoëy, J. -- Clinical genetics of congenital hypothyroidism / Szinnai, G. -- Central hypothyroidism in children / Garcí́a, M., Fernssndez, A., Moreno, J.C. -- Thyroid hormone cell membrane transport defect / Ramos, H.E. -- Resistance to thyroid hormone / Onigata, K., Szinnai, G. -- Iodine deficiency in children / Pearce, E.N. -- Thyroid autoimmunity / Wiersinga, W.M. -- Clinical aspects of Hashimoto's thyroiditis / Radetti, G. -- Graves' disease in children / Léger, J. -- Thyroid nodules and differentiated thyroid cancer / Bauer, A.J. -- Medullary thyroid carcinoma in children / Viola, D., Romei, C.; Elisei, R.
  • Introduction to Diabetic Neuropathies -- Classification and Clinical Features -- Diagnosis and Staging -- Management of Neuropathic Pain.
  • Embryonic development and anatomic and histological structure of the parathyroid glands -- Preoperative imaging of the parathyroid glands -- Intraoperative imaging of the parathyroid glands -- Image-Guided minimally invasive modalities in surgical treatment of parathyroid diseases.

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