Books by Subject
- 2012 SpringerKursad Turksen, editor.
- v. 177-221, 2005-16. SpringerAlso available: Print – v. 47-97, 99-156, 171, 1973-2000, 2003.
- 2007 CRCnetBASEedited by Malcolm Whitman, Amy K. Sater.
- 2008 ScienceDirectedited by Dr. Marianne Bronner-Fraser.Also available: Print – 2008
- 2016 ClinicalKeyKeith L. Moore, T.V.N. Persaud, Mark G. Torchia.Introduction to human development -- Human reproduction -- First week of development -- Second week of development -- Third week of development -- Development during weeks four to eight -- Fetal period : the ninth week to birth -- Placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- Pharyngeal apparatus -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Musculoskeletal system -- Nervous system -- Eyes and ears -- Integumentary system -- Human birth defects -- The cellular and molecular basis of development.
- 2006 Springer[edited by] Jamie A. Davies.Why a book on branching, and why now? / Jamie A. Davies -- Branching morphogenesis in vertebrate neurons / Katherine M. Kollins and Roger W. Davenport -- Branching of single cells in arabidopsis / Daniel Bouyer and Martin Hülskamp -- Branching in fungal hyphae and fungal tissues: growing mycelia in a desktop computer / David Moore, Liam J. McNulty, and Audrius Meskauskas -- Branching in colonial hydroids / Igor A. Kosevich -- How is the branching of animal blood vessels implemented? / Sybill Patan -- Extracellular matrix remodeling in mammary gland branching morphogenesis and breast cancer: the double-edged sword / Eva A. Turley and Mina J. Bissell -- Branching morphogenesis in mammalian kidneys / Jamie A. Davies -- Embryonic salivary gland branching morphogenesis / Tina Jaskoll and Michael Melnick -- Branching morphogenesis of the prostate / A.A. Thomson and P.C. Marker -- Uterine glands / Thomas E. Spencer ... [et al.] -- Physical mechanisms of branching morphogenesis in animals: from viscous fingering to cartilage rings / Vincent Fleury ... [et al.].
- 2012 Springer Protocolsedited by Xu Peng, Marc Antonyak.Use of whole embryo culture for studying heart development / Calvin T. Hang and Ching-Pin Chang -- Quantifying cardiac functions in embryonic and adult zebrafish / Tiffany Hoage, Yonghe Ding, and Xiaolei Xu -- Analysis of the patterning of cardiac outflow tract and great arteries with angiography and vascular casting / Ching-Pin Chang -- Morpholino injection in Xenopus / Panna Tandon [and others] -- Chicken chorioallantoic membrane angiogenesis model / Domenico Ribatti -- Visualizing vascular networks in zebrafish : an introduction to microangiography / Christopher E. Schmitt, Melinda B. Holland, and Suk-Won Jin -- Whole-mount confocal microscopy for vascular branching morphogenesis / Yoh-suke Mukouyama [and others] -- Visualization of mouse embryo angiogenesis by fluorescence-based staining / Yang Liu, Marc Antonyak, and Xu Peng -- Miniaturized assays of angiogenesis in vitro / May J. Reed and Robert B. Vernon -- Analysis of the endocardial-to-mesenchymal transformation of heart valve development by collagen gel culture assay / Yiqin Xiong, Bin Zhou, and Ching-Pin Chang -- Quantification of myocyte chemotaxis : a role for FAK in regulating directional motility / Britni Zajac [and others] -- Analysis of neural crest cell fate during cardiovascular development using Cre-activated lacZ/[beta]-galactosidase staining / Yanping Zhang and L. Bruno Ruest -- Indirect immunostaining on mouse embryonic heart for the detection of proliferated cardiomyocyte / Jieli Li, Marc Antonyak, and Xu Peng -- Isolation and characterization of vascular endothelial cells from murine heart and lung / Yixin Jin [and others] -- Isolation and characterization of embryonic and adult epicardium and epicardium-derived cells / Bin Zhou and William T. Pu -- Vascular smooth muscle cells : isolation, culture, and characterization / Richard P. Metz, Jan L. Patterson, and Emily Wilson -- C-kit expression identifies cardiac precursor cells in neonatal mice / Michael Craven, Michael I. Kotlikoff, and Alyson S. Nadworny -- Cardiomyocyte apoptosis in heart development : methods and protocols / Dongfei Qi and Mingui Fu -- Adenovirus-mediated gene transfection in the isolated lymphatic vessels / Anatoliy A. Gashev [and others] -- Isolation of cardiac myocytes and fibroblasts from neonatal rat pups / Honey B. Golden [and others] -- The application of genome-wide RNAi screens in exploring varieties of signaling transduction pathways / Shenyuan Zhang and Hongying Zheng -- Application of atomic force microscopy measurements on cardiovascular cells / Xin Wu [and others] -- In utero assessment of cardiovascular function in the embryonic mouse heart using high-resolution ultrasound biomicroscopy / Honey B. Golden [and others] -- Isolation and preparation of RNA from rat blood and lymphatic microvessels for use in microarray analysis / Eric A. Bridenbaugh -- Visual data mining of coexpression data to set research priorities in cardiac development research / Vincent VanBuren -- High-speed confocal imaging of zebrafish heart development / Jay R. Hove and Michael P. Craig -- Measurement of electrical conduction properties of intact embryonic murine hearts by extracellular microelectrode arrays / David G. Taylor and Anupama Natarajan.
- 2015 SpringerHenry J. Leese, Daniel R. Brison, editors.The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.Also available: Print – 2015
- Chick embryo chorioallantoic membrane in the study of angiogenesis and metastasis : the CAM assay in the study of angiogenesis and metastasis2010 SpringerDomenico Ribatti.
- 2013Chien-Jung Lin.During embryonic development, dynamic remodeling of the chromatin landscape is required for the transcriptional machinery to access the genomic DNA in a spatiotemporally controlled manner. This intricate level of regulation allows precise gene regulation, necessary for complex morphogenetic processes. The Brg1/Brm-associated factor (BAF) complex is a multisubunit, ATP-dependent chromatin remodeling complex. Among the subunits, Brg1 is an ATPase that is critical for the function of the complex. Here, we study the role of Brg1 in foregut and cardiac outflow tract development. In the foregut, Brg1 functions with HDAC proteins in the ventral epithelium to regulate Nkx2-1 expression, essential for foregut septation into trachea and esophagus. In the absence of Brg1, embryos develop a single-tube foregut, reminiscent of human patients with tracheoesophageal fistula. In the developing heart, Brg1 functions in the secondary heart field-derived myocardium to control Semaphorin 3c (Sema3c) expression, essential for the outflow tract to septate into pulmonary artery and aorta. Deletion of Brg1 in the secondary heart field results in decreased neural crest cell colonization of the outflow tract, leading to a phenotype similar to the persistent truncus arteriosus pathology. Brg1 cooperates with HDAC proteins and Chd7 in the outflow tract myocardium to control Sema3c expression. These studies demonstrate novel functions and molecular mechanisms of Brg1 in foregut and cardiovascular development.
- Clinical neuroembryology : development and developmental disorders of the human central nervous system. Second edition [2nd ed.]2014 SpringerHans J. ten Donkelaar, Martin Lammens, Akira Hori.This book provides a comprehensive overview of the development of the human central nervous system (CNS) in the context of its many developmental disorders due to genetic, environmental, and hypoxic/ischemic causes. The introductory chapters give an overview of the development of the human brain and the spinal cord, the mechanisms of development as obtained in experimental studies of various invertebrates and vertebrates, and the causes of congenital malformations. In the main part, the developmental disorders of the human brain and the spinal cord are presented in a regional, more or less segmental way, starting with neurulation and neural tube defects, and ending with developmental disorders of the cerebral cortex. These are underlined by carefully chosen clinical case studies, including imaging data and, when available, postmortem verification of the developmental disorders involved. Numerous color photographs and illustrations complement the text. This second edition emphasizes the prenatal diagnosis by ultrasound, MRI, and DTI and implements new classifications of developmental disorders.
- 2011 Springereditors, Linda M. Ernst, Eduardo D. Ruchelli and Dale S. Huff.This book serves as a comprehensive atlas of the developmental histology of the major organs from 15 weeks gestation to the neonatal period. Each section includes text on basic embryologic processes that influence the development of each organ and highlight major histologic features that correspond with certain developmental periods. In addition, there are many color photomicrographs at key developmental stages to assist the reader in identifying appropriate histologic changes at each developmental stage. This book will be of great value to students of embryology, pathology residents and fellows, and attending pathologists who perform fetal autopsies.
- 2007- Wileyeditorial board, Thorsten Schlaeger (editor-in-chief), Roger Patient, Evan Snyder, Joseph Wu, Yukiko Yamashita ; past editors, Mick Bhatia, Andrew G. Elefany, Susan J. Fisher.Includes methods for isolating, maintaining, and differentiating embryonic and adult stem cells.
- 2008Keith L. Moore, T.V.N. Persaud ; with the collaboration of Mark G. Torchia.Introduction to the developing human -- The beginning of human development: first week -- Formation of bilaminar embryonic disc: second week -- Formation of germ layers and early tissue and organ differentiation: third week -- Organogenetic period: fourth to eighth weeks -- The fetal period: ninth week to birth -- the placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- The pharyngeal apparatus -- The respiratory system -- The digestive system -- The urogenital system -- The cardiovascular system -- The skeletal system -- The muscular system -- The limbs -- The nervous system -- The eye and ear -- The integumentary system -- Congenital anatomical anomalies or human birth defects -- Common signaling pathways used during development.
- 2013Keith L. Moore, T.V.N. Persaud, Mark G. Torchia.Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth: the fetal period -- Placenta and fetal membranes -- Body cavities and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
- 2016 ClinicalKeyKeith L. Moore, T.V.N. (Vid) Persaud, Mark G. Torchia.Introduction to the developing human -- First week of human development -- Second week of human development -- Third week of human development -- Fourth to eighth weeks of human development -- Ninth week to birth : the fetal period -- Placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- Pharyngeal apparatus, face, and neck -- Respiratory system -- Alimentary system -- Urogenital system -- Cardiovascular system -- Skeletal system -- Muscular system -- Development of limbs -- Nervous system -- Development of eyes and ears -- Integumentary system -- Human birth defects -- Common signaling pathways used during development.
- 2010 SpringerAlessandra Piontelli.General movements -- Startles, twitches and clonuses -- Hiccups, yawning and gasping -- Fetal breathing movements -- Swallowing, sucking and handedness as inferred from fetal thumb sucking -- Localized movements -- Facial expressions -- Rest-activity cycles, clusters and the ontogeny of sleep -- Twin fetuses and twin myths -- Conclusions: movement is life.
- 2015 SpringerAlessandra Piontelli.
- 2005 Springeredited by Mahendra S. Rao and Marcus Jacobson.Also available: Print – 2005
- 2012 Springer Protocolsedited by Craig Harris, Jason M. Hansen.In vivo models of developmental toxicology / Jason M. Hansen -- Caenorhabditis elegans as a model in developmental toxicology / Windy A. Boyd, Marjolein V. Smith, and Jonathan H. Freedman -- Zebrafish embryo developmental toxicology assay / Julieta M. Panzica-Kelly, Cindy X. Zhang, and Karen Augustine-Rauch -- Gene knockdown by morpholino-modified oligonucleotides in the Zebrafish (Danio rerio) model : applications for developmental toxicology / Alicia R. Timme-Laragy, Sibel I. Karchner, and Mark E. Hahn -- Amphibian model for studies of developmental reproductive toxicity / Cecilia Berg -- Avian models in teratology and developmental toxicology / Susan M. Smith, George R. Flentke, and Ana Garic -- Overview of in vitro models in developmental toxicology / Craig Harris -- Primary cell and micromass culture in assessing developmental toxicity / M. Pratten -- Embryonic stem cell test : stem cell use in predicting developmental cardiotoxicity and osteotoxicity / Beatrice Kuske, Polina Y. Pulyanina, and Nicole I. zur Nieden -- Mouse embryonic stem cell adherent cell differentiation and cytotoxicity assay / Marianne Barrier [and others] -- Murine limb bud in culture as an in vitro teratogenicity test System / France-Helene Paradis, Chunwei Huang, and Barbara F. Hales -- Rodent whole embryo culture / Craig Harris -- Rabbit whole embryo culture / Valerie A. Marshall and Edward W. Carney -- Assessment of xenobiotic biotransformation including reactive oxygen species generation in the embryo using benzene as an example / Helen J. Renaud, Allison Rutter, and Louise M. Winn -- Methodological approaches to cytochrome P450 profiling in embryos / Jared V. Goldstone and John J. Stegeman -- Analysis of Nrf2-mediated transcriptional induction of antioxidant response in early embryos / Shao-yu Chen -- Regulation and control of AP-1 binding activity in embryotoxicity / Terence R.S. Ozolins -- Thioredoxin redox status assessment during embryonic development : the redox western / Jason M. Hansen -- Methods for the determination of plasma or tissue glutathione levels / Trent E. Tipple and Lynette K. Rogers -- Oxidative stress, thiols, and redox profiles / Craig Harris and Jason M. Hansen -- Review of toxicogenomic approaches in developmental toxicology / Joshua F. Robinson, Jeroen L.A. Pennings, and Aldert H. Piersma -- Epigenetic approaches and methods in developmental toxicology: role of HDAC inhibition in teratogenic events / Elena Menegola, Graziella Cappelletti, and Francesca Di Renzo -- DNA methylation screening and analysis / Karilyn E. Sant, Muna S. Nahar, and Dana C. Dolinoy -- Assessment of histiotrophic nutrition using fluorescent probes / Jeffrey Ambroso and Craig Harris -- Diabetic embryopathy / Ulf J. Eriksson and Parri Wentzel -- Gene expression analysis in developing embryos : in situ hybridization / Siew-Ging Gong -- Assessment of gross fetal malformations : the modernized wilson technique and skeletal staining / Robert E. Seegmiller [and others].
- Dynamics of the mammalian sperm head : modifications and maturation events from spermatogenesis to egg activation2009 SpringerKiyotaka Toshimori.In humans, male infertility is caused by a number of factors such as the external environment, nutrient changes, genotoxins, and mutagens. This book discusses the events that occur in the normal sperm head and govern the structure-function relationship from the time of spermatogenesis to that of fertilization or egg activation.
- 2007 SpringerWijnand F.R.M. Koch, Enrico Marani.
- 2006 Springeredited by E. Marelyn Wintour, Julie A. Owens.1. The Developmental origins of health and disease: the breadth and importance of the concept / Peter D. Gluckman and Mark A. Hanson -- 2. Developmental origins of cardiovascular disease, type 2 diabetes, and obesity in humans / Caroline H.D. Fall -- 3. Studies of twins: what can they tell us about the developmental origins of adult health and disease? / Ruth Morley, Terence Dwyer, and John B. Carlin -- 4. Prenatal programming of human motor function / Julia B. Pitcher, David J. Henderson-Smart, and Jeffrey S. Robinson -- 5. Adaptive responses of early embryos to their microenvironment and consequences for post-implantation development / Jeremy Thompson, Michelle Lane, and Sarah Robertson -- 6. Modification of epigenetic state through dietary manipulation in the developing mammalian embryo / Nicola Vickaryous and Emma Whitelaw -- 7. Critical experiments to determine if early nutritional influences on epigenetic mechanisms cause metabolic imprinting in humans / Robert A. Waterland -- 8. Manipulation of the maternal diet in rat pregnancy: different approaches to the demonstration of the programming principle / Simon C. Langley-Evans [et al.] -- 9. Programming hypertension-animal models: causes and mechanisms / Kate M. Denton, Michelle M. Kett, and Miodrag Dodic -- 10. Developmental programming of cardiovascular dysfunction / Lucilla Poston, James A. Armitage, and Paul D. Taylor -- 11. Kidney development and fetal programming / Karen M. Moritz and Luise A. Cullen-McEwen -- 12. Programming of obesity-experimental evidence / Bernhard H. Breier, Stefan O. Krechowec, and Mark H. Vickers -- 13. Perinatal programming of adult metabolic homeostasis: lessons from experimental studies / Kathryn l. Gatford ... [et al.] -- 14. Programming effects of excess glucocorticoid exposure in late gestation / Timothy J.M. Moss and Deborah M. Sloboda -- 15. Programming effects of moderate and binge alcohol consumption / Jeff Schwartz and Luke C. Carey -- 16. Vitamin D in pregnancy and offspring health / Marianne Tare, Helena C. Parkington, and Ruth Morley -- 17. The Fetal origins of adult mental illness / Laura Bennet and Alistair J. Gunn -- 18. Hypoxia, fetal growth and developmental origins of health and disease / Dino A. Giussani.Also available: Print – 2006
- 2012 Springer Protocolsedited by Gary D. Smith, Jason E. Swain, Thomas B. Pool.Historical background of gamete and embryo culture / Jacques Cohen and Don Rieger -- Utility of animal models for human embryo culture development : rodents / Gary D. Smith -- Utility of animal models for human embryo culture development : domestic species / Rebecca L. Krisher -- Utility of animal models for human embryo culture : nonhuman primates / Calvin Simerly and Gerald Schatten -- Media composition : salts and osmolality / Jay M. Baltz -- Media composition : energy sources and metabolism / Deirdre Zander-Fox and Michelle Lane -- Media composition : amino acids and cellular homeostasis / Franchesca D. Houghton -- Media composition : macromolecules and embryo growth / Marius Meintjes -- Media composition : antioxidants/chelators and cellular function / Catherine M.H. Combelles and Margo L. Hennet -- Media composition : pH and buffers / Jason E. Swain -- Media composition : growth factors / Aparna Hegde and Barry Behr -- Culture systems : single step / Ronit Machtinger and Catherine Racowsky -- Culture systems : sequential / Patrick Quinn -- Culture systems : embryo co-culture / Yves J.R Menezo [and others] -- Culture systems : low-oxygen culture / Borut Kovacice -- Culture systems : embryo density / Michael L. Reed -- Culture systems : air quality / Theodore Thomas -- Culture systems : mineral oil overlay / Dean E. Morbeck and Phoebe H. Leonard -- Culture systems : physiological and environmental factors that can affect the outcome of human ART / Don Rieger -- Culture systems : fluid dynamic embryo culture systems (microfluidics) / Andre Monteiro da Rocha and Gary D. Smith -- Human embryo culture media comparisons / Thomas B. Pool, John Schoolfield, and David Han -- Culture systems : embryo culture and monozygotic twinning / Amy E. Sparks -- Embryo culture and epigenetics / Brenna A. Market Velker, Michelle M. Denomme, and Mellissa R.W. Mann.
- 2009Barry Mitchell, Ram Sharma ; illustrations by Robert Britton.How does an embryo form? -- How do the placenta and fetal membranes form? -- The body cavities and the diaphragm -- The integumentary, skeletal, and muscular systems -- The respiratory system -- The cardiovascular system -- The digestive system -- The urinary system -- The reproductive system -- The nervous system -- Development of the head and neck, the eye, and the ear.
- 2008Ronald W. Dudek, James D. Fix.
- v. 1-2, 2006 Springer Protocolsv. 2, 2006 Springer Protocolsedited by Kursad Turksen.v. 1. Isolation and characterization -- v. 2. Differentiation models.
- 2007 Springeredited by John R. Masters, Bernhard O. Palsson and James A. Thomson.Defined culture media for human embryonic stem cells / T. Ludwig and J. Thomson -- Generation of disease-specific human embryonic stem cell lines / S. Minger -- Characterization and differentiation of human embryonic stem cells / A. Laslett ... [et al.] -- Genetic modification of human embryonic stem cells / T. Zwaka -- Hematopoietic differentiation / C. Cerdan ... [et al.] -- Neural differentiation / Z.-J. Zhang ... [et al.] -- Germ cell differentiation / V. Angeles and R. Pera -- Mesodermal differentiation / N. Sharon and N. Benvenisty -- Three-dimensional culture of human embryonic stem cells / S. Gerecht ... [et al.] -- Extraembryonic cell differentiation / L. Armstrong and M. Lako -- Pancreatic cell differentiation / B. Fishman ... [et al.] -- Cardiomyocyte differentiation / D. Singla ... [et al.] -- Human embryonal carcinoma (EC) cells: Complementary tools for embryonic stem cell research / P. Tonge and P. Andrews -- Quality control of human stem cell lines / G. Stacey.
- 2013 Springer Protocolsedited by Ramiro Alberio.Generation and Characterization of Epiblast Stem Cells from Blastocyst-stage Mouse Embryos -- Reversion of Mouse Post-Implantation Epiblast Stem Cells to a Naïve Pluripotent State by Modulation of Signalling Pathways -- Converting Mouse Epiblast Stem Cells into Mouse Embryonic Stem Cells by using Small Molecules -- Isolation and Culture of Rabbit Embryonic Stem Cells -- Goat Embryonic Stem-like Cell Derivation and Characterization -- Derivation and Culture of Canine Embryonic Stem Cells -- Isolation and Culture of Porcine Embryonic Stem Cells -- Isolation and Culture of Pig Epiblast Stem Cells -- Isolation and Culture of Bovine Embryonic Stem Cells -- Analysis of Molecular Markers for Staging Peri-gastrulating Bovine Embryos -- Chicken Embryonic Stem Cells: Establishment and Characterization -- Manipulating the Avian Epiblast and Epiblast-derived Stem Cells -- Stepwise Differentiation from Naïve State Pluripotent Stem Cells to Functional Primordial Germ Cells through an Epiblast-like State -- Isolation and Culture of Porcine Neural Progenitor Cells from Embryos and Pluripotent Stem Cells -- Derivation of Neural Precursors from Bovine Pre-implantation Embryos.
- 2011 SpringerTamara Fischmann, Elisabeth Hildt, editors.Ethical Dilemmas Due to Prenatal and Genetic Diagnostics: An Interdisciplinary, European Study (EDIG, 2005-2008) / Marianne Leuzinger-Bohleber -- Managing Complex Psychoanalytic Research Projects Applying Mapping Techniques - Using the Example of the EDIG Study / Nicole Pfenning-Meerkötter -- Distress and Ethical Dilemmas Due to Prenatal and Genetic Diagnostics - Some Empirical Results / Tamara Fischmann -- Reconstruction of Pregnant Women's Subjective Attitudes Towards Prenatal Diagnostics - A Qualitative Analysis of Open Questions / Katrin Luise Läzer -- Prenatal Testing: Women's Experiences in Case of a Conspicuous Test Result / Elisabeth Hildt -- Caring for Women During Prenatal Diagnosis: Personal Perspectives from the United Kingdom / Helen Statham and Joanie Dimavicius -- Cooperation Is Rewarding If the Boundary Conditions Fit: Interdisciplinary Cooperation in the Context of Prenatal Diagnostics / Astrid Riehl-Emde, Anette Bruder, Claudia Pauli-Magnus, and Vanessa Sieler -- Prenatal Genetic Counselling: Reflections on Drawing Policy Conclusions from Empirical Findings / Anders Nordgren -- Taking Risk in Striving for Certainty. Discrepancies in the Moral Deliberations of Counsellors and Pregnant Women Undergoing PND / László Kovács -- Ethical Thoughts on Counselling and Accompanying Women and Couples Before, During and After Prenatal Diagnosis / Dierk Starnitzke -- Client, Patient, Subject; Whom Should We Treat? On the Significance of the Unconscious in Medical Care and Counselling / Yair Tzivoni -- Decision to Know and Decision to Act / Regina Sommer -- Moral Decision-Making, Narratives and Genetic Diagnostics / Göran Collste -- Prenatal Diagnostics and Ethical Dilemmas in a Mother Having a Child with Down Syndrome / Maria Samakouri, Evgenia Tsatalmpasidou, Konstantia Ladopoulou, Magdalini Katsikidou, Miltos Livaditis, and Nicolas Tzavaras -- Is There One Way of Looking at Ethical Dilemmas in Different Cultures? / Stephan Hau.
- 2012 ClinicalKey[edited by] Jack Rychik, Zhiyun Tian.Complied by the team at the Cardiac Center at Children's Hospital in Philadelphia, this Expert Consult site and accompanying atlas-style text guide the acquisition and interpretation of fetal images for accurate diagnosis and effective management. Vivid color images, drawings, pathologic specimens and diagnostic algorithms facilitate tracking the progress of development of over 100 fetal heart problems. Enhance your cardiac imaging skills with a video library demonstrating imaging of the normal heart, and the imaging presentation of more than 100 different fetal heart problems. Recognize potential problems using views of the normal heart in development for comparative diagnosis. Get comprehensive coverage of cardiac anatomy, pathophysiology, natural history and disease management. See developing and existing problems as they appear in practice thanks to an abundance of vivid color images, drawings, pathologic specimens, and diagnostic algorithms. Track the progress of development in the fetal heart by using the best imaging modalities & techniques for more accurate diagnosis.
- 2016 Cambridgeedited by Bidyut Kumar, MD, FRCOG, Consultant Obstetrician and Gynaecologist, Wrexham Maelor Hospital, Betsi Cadwaladr University Health Board, Wrexham, North Wales, Honorary Lecturer, Cardiff University, and Honorary Senior Lecturer, Bangor University, Gwyneddn Wales, UK, Zarko Alfirevic, MD, FRCOG, Professor of Fetal and Internal Medicine and Head of Department of Women's and Children's Health at University of Liverpool and Honorary Consultant Obstretician at Liverpool Women's Hospital, UK.Section 1. Genetics and antenatal screening -- Section 2. Embryology, fetal physiology and fetal anatomy -- Section 3. Fetal anomalies -- Section 4. Fetal disease -- Section 5. Termination of pregnancy -- Section 6. Fetal growth and wellbeing -- Section 7. Multiple pregnancy -- Section 8. Placenta, amniotic membrane and amniotic fluid -- Section 9. Diagnostic and therapeutic invasive procedures -- Index.
- 2011 SpringerDaniela Prayer (ed.).Indications for Fetal MRI -- How to Shorten MRI Sequences Guiding Choices for High Speed Imaging -- Fetal MRI at Higher Field Strength -- Safety of Fetal MRI Scanning -- The Psychic State of the Pregnant Woman and Prenatal Diagnostic Procedures -- Methods of Fetal MRI -- Prenatal Development of the Human Fetal Telencephalon -- Fetal MRI of Normal Brain Development -- Fetal Movements. Though They May Be Spontaneous, Yet There is Method in Them -- The Fetal Neurology Clinic A Multidisciplinary Approach Fetal Neuroimaging: Ultrasound or MRI? -- MRI of the Normal Fetal Lung -- The Skeleton and Musculature -- MRI of the Fetal Heart -- MRI of the Fetal Endocrine Glands -- The Prenatal Diagnosis of Facial Clefts with Fetal MRI -- Cerebral Malformations -- Acquired Brain Pathology -- Diagnosis of Congenital Diaphragmatic Hernia -- Treatment of Congenital Diaphragmatic Hernia -- MRI of the Pathological Fetal Thorax -- MRI of the Fetal Abdomen -- Normal and Pathological Placental Development: MRI and Pathology -- Problems of Multiple Pregnancies Ultrasound and MRI -- Fetal Perinatal Autopsy and MRI: Synthesis or Alternative? -- Postmortem Magnetic Resonance Imaging of the Fetus -- Genetics of Fetal Disease -- Maternal Diseases with Possible Impact on Pregnancy.
- 2014 SpringerHe-Feng Huang, Jian-Zhong Sheng, editors.The book Gamete and Embryo-fetal Origins of Adult Diseases introduces various diseases resulting from the abnormal gametogenesis and embryo development, which manifests as growth retardation, birth defects, or increased susceptibility to chronic metabolic diseases such as diabetes, cardiovascular disease and cancer in childhood and adult life, even fertility disorders and the risk of transgenerational transmission. Six common kinds of these diseases are discussed in separate chapters. The authors explore the connections between these diseases and epigenetic reprogramming, rapid cell differentiation and organ formation and environmental influences, including assisted reproductive technology and adverse intrauterine environments. With a summary of findings on the causes and progression of adult diseases at the phase of gametogenesis and embryo development, this book provides insights into the pathogenesis of disease and aids in the treatment and prevention of disease, meeting the requirement for improving the quality of the newborn population, and effectively preventing and curing major diseases at an early stage. This book offers new perspectives and will be an enlightening resource for obstetricians, paediatricians, epidemiologists, endocrinologists and sanitarians.
- 2013 SpringerTiziana A.L. Brevini, Georgia Pennarossa.This Brief offers a concise, handy overview of the main concepts related to Embryology, revisited through the novel concepts that are applied daily in stem cell research and cell therapy oriented investigations. It is based on three main areas: -The process involved in female gamete differentiation and maturation. The main aspects related to cell biology will be covered and an overview of the epigenetic regulation of gametogenesis will be presented. -Early stages of embryo development with a careful analysis of the regulatory mechanisms driving cleavage, polarization and genome activation. -Stem cell and gametogenesis. The use of the oocyte as a possible source for the derivation of stem cell lines is discussed and depicted as a powerful tool to investigate oocyte potency and asymmetric imprinting. The potential biological implications are evaluated and use of stem cells to derive oocytes is presented.
- 2014 ScienceDirectedited by B. Anne Croy, Aureo T. Yamada, Francesco J. DeMayo, S. Lee Adamson.The Guide to Investigation of Mouse Pregnancy is the first publication to cover the mouse placenta or the angiogenic tree the mother develops to support the placenta. This much-needed resource covers monitoring of the cardiovascular system, gestational programming of chronic adult disease, epigenetic regulation, gene imprinting, and stem cells. Offering detailed and integrated information on how drugs, biologics, stress, and manipulations impact pregnancy in the mouse model, this reference highlights techniques used to analyze mouse pregnancy.
- 2010 ScienceDirectedited by Paul M. Wassarman and Philippe Soriano.Also available: Print – 2010
- 2013 CambridgeEleonora Porcu, Patrizia Maria Ciotti, Stefano Venturoli."Human oocyte cryopreservation has undergone rapid growth, with technical improvement and increasing clinical application over the last ten years. Storing eggs is ethical and gives many young women their most realistic chance of conception. Cryopreservation, however, is still considered by many as an experimental technique and conflicting reports are published as to its efficacy. For these reasons, it is necessary to give reproductive researchers and practitioners comprehensive and systematic information about the field. This book describes and analyses the history of human oocyte freezing, the main steps of technical evolution, and the pros and cons of different techniques. In addition, the clinical applications, long-term outcome, efficiency and safety of oocyte cryopreservation are detailed. The Handbook of Human Oocyte Cryopreservation gives a complete picture of the field today and is a valuable text for embryologists, cryobiologists, reproductive medicine practitioners and anyone involved in researching and implementing the technique"--Provided by publisher.
- 2007Ronald W. Dudek.Prefertilization events -- Week 1 (days 1-7) -- Week 2 (days 8-14) -- Embryonic period (weeks 3-8) -- Placenta, amniotic fluid, and umbilical cord -- Cardiovascular system -- Digestive system -- Urinary system -- Female reproductive system -- Male reproductive system -- Respiratory system -- Head and neck -- Nervous system -- Ear -- Eye -- Body cavities -- Integumentary system -- Skeletal system -- Muscular system -- Pregnancy -- Numerical chromosomal anomalies -- Structural chromosomal anomalies -- Single-gene inherited diseases -- Multifactorial inherited diseases -- Teratology.
- 2010Ronald W. Dudek.Prefertilization events -- Week 1 (days 1-7) -- Week 2 (days 8-14) -- Embryonic period (weeks 3-8) -- Placenta, amniotic fluid, and umbilical cord -- Cardiovascular system -- Digestive system -- Urinary system -- Female reproductive system -- Male reproductive system -- Respiratory system -- Head and neck -- Nervous system -- Ear -- Eye -- Body cavities -- Pregnancy -- Teratology.
- 2014 ClinicalKeyBruce M. Carlson.Master the concepts you need to know with Human Embryology and Developmental Biology. Dr. Bruce M. Carlson's clear explanations provide an easy-to-follow "road map" through the most up-to-date scientific knowledge, giving you a deeper understanding of the key information you need to know for your courses, exams, and ultimately clinical practice. Visualize normal and abnormal development with hundreds of superb clinical photos and embryological drawings.Access the fully searchable text online, view animations, answer self-assessment questions, and much more at www.studentconsult.com.
- 2010 Springer Protocolsedited by Kursad Turksen.Human embryo culture and assessment for the derivation of embryonic stem cells (ESC) / A. Henry Sathananthan and Tiki Osianlis -- Derivation of human embryonic stem cell lines from vitrified human embryos / Teija T. Peura, Julia Schaft, and Tomas Stojanov -- Growth of human embryonic stem cells using derivates of human fibroblasts / Carmen Escobedo-Lucea and miodrag Stojkovic -- In vitro neural differentiation of human embronic stem cells using a low-density mouse embryonic fibroblast feeder protocol / John A. Ozolek [and others] -- Optimization of physiological xenofree molecularly defined media and matrices to maintain human embryonic stem cell pluripotency / Isabelle Pfeiffer [and others] -- Serum-free and feeder-free culture expansion of human embryonic stem cells / Katherine E. Wagner and Mohan C. Vemuri -- Single cell enzymatic dissociation of human embryonic stem cells : a straightforward, robust, and standardized culture method / Catharina Ellerström, Johan Hyllner, and Raimund Strehl -- Monitoring stemness in long-term hESC cultures by real-time PCR / Amparo Galán and Carlos Simón -- Culture and preparation of human embryonic stem cells for proteomics-based applications / Charles C. King -- A two- and three-dimensional approach for visualizing human embryonic stem cell differentiation / Christian B. Brøchner [and others] -- Immunofluorescence and mRNA analysis of human embryonic stem cells (hESCs) grown under feeder-free conditions / Aashir Awan [and others] -- Study of gap junctions in human embryonic stem cells / Raymond C.B. Wong and Alice Pébay -- hESC engineering by integrase-mediated chromosomal targeting / Ying Liu [and others] -- Human embryonic stem cell differentiation on periodontal ligament fibroblasts / Y. Murat Elc̦in, Bülend İnanc̦, and A. Eser Elc̦in -- Generation of neural crest cells and peripheral sensory neurons from human embryonic stem cells / Ronald S. Goldstein [and others] -- Embryonic stem cells as a model for studying melanocyte development / Susan E. Zabierowski and Meenhard Herlyn -- In vitro derivation of chondrogenic cells from human embryonic stem cells / Wei Seong Toh [and others] -- Vascular differentiation of human embryonic stem cells in bioactive hydrogel-based scaffolds / Sharon Gerecht, Lino S. Ferreira, and Robert Langer -- Differentiation of neural precursors and dopaminergic neurons from human embryonic stem cells / Xiao-Quing Zhang and Su-Chung Zhang -- Transplantation of human embryonic stem cells and derivatives to the chick embryo / Ronald S. Goldstein -- Genetic manipulation of human embryonic stem cells / Silvina Epsztejn-Litman and Rachel Eiges -- Genetic manipulation of human embryonic stem cells in serum and feeder-free media / Stefan R. Braam, Chris Denning, and Christine L. Mummery -- Human-induced pluripotent stem cells : derivation, propagation, and freezing in serum- and feeder layer-free culture conditions / Hossein Baharvand [and others].
- 2015 Springer Protocolsedited by Kursad Turksen.Derivation of human embryonic stem cell lines from vitrified human blastocysts / Cara K. Bradley ... [et al.] - Characterizing pluripotent stem sells using the TaqMan® hPSC scorecardTM panel / Jeffrey Fergus, Rene Quintanilla, and Uma Lakshmipathy -- Growth of human pluripotent stem cells using functional human extracellular matrix / Andres Sanz-Garcia, Miodrag Stojkovic, and Carmen Escobedo-Lucea -- Efficient expansion of dissociated human pluripotent stem cells using a synthetic substrate / Eihachiro Kawase -- Microarray approach to identify the signaling network responsible for self-renewal of human embryonic stem cells / Noboru Sato and Ali Brivanlou -- Monitoring stemness in long-term hESC sultures by real-time PCR / Amparo Galan and Carlos Simon -- Study of gap junctions in human embryonic stem cells / Alice Pebay and Raymond C.B. Wong -- Immunofluorescence microscopy and mRNA analysis of human embryonic stem cells (hESCs) including primary cilia associated signaling pathways / Maj Linea Vestergaard ... [et al.] -- Analysis of intracellular calcium signaling in human embryonic stem cells / Adrienn Pentek, Katalin Paszty, and Agota Apati -- Genetic manipulation of human embryonic stem cells / Rachel Eiges -- Genetic modification in human pluripotent stem cells by homologous recombination and CRISPR/Cas9 system / Haipeng Xue ... [et al.] -- Use of multicolor flow cytometry for isolation of specific cell populations deriving from differentiated human embryonic stem cells / Isabella Mengarelli, Andrew Fryga, and Tiziano Barberi -- Definitive endoderm differentiation of human embryonic stem cells combined with selective elimination of undifferentiated cells by methionine deprivation / Tomonori Tsuyama, Nobuaki Shiraki, and Shoen Kume -- Derivation of endothelial cells and pericytes from human pluripotent stem cells / Sravanti Kusuma and Sharon Gerecht -- Differentiation of human embryonic stem cells on periodontal ligament fibroblasts / Y. Murat Elcin, Bulend Inanc, and A. Eser Elcin -- Derivation of epithelial cells from human embryonic stem cells as an in vitro model of vocal mucosa / Vlasta Lungova, Ciara Leydon, and Susan Thibeault -- Human embryonic and hepatic stem cell differentiation visualized in two and three dimensions based on serial sections / Peter S. Vestentoft ... [et al.] -- Derivation of chondrogenic cells from human embryonic stem cells for cartilage tissue engineering / Wei Seong Toh and Tong Cao -- Microgrooved surface modulates neuron differentiation in human embryonic stem cells / David Lu ... [et al.] -- Directed differentiation of human embryonic stem cells into neural progenitors / Erin Banda and Laura Grabel -- Direct conversion of pluripotent human embryonic stem cells under defined culture conditions into human neuronal or cardiomyocyte cell therapy derivatives / Xuejun H. Parsons -- Generation of epithelial cell populations from human pluripotent stem cells using a small-molecule inhibitor of Src family kinases / Joshua A. Selekman, Xiaojun Lian, and Sean P. Palecek -- Dual-SMAD inhibition/WNT activation-based methods to induce neural crest and derivatives from human pluripotent stem cells / Stuart M. Chambers ... [et al.] -- Accelerated three-dimensional neuroepithelium formation from human embryonic stem cells and its use for quantitative differentiation to human retinal pigment epithelium / Yu Zhu, Sven Schreiter, and Elly M. Tanaka -- Efficient production of photoreceptor precursor cells from human embryonic stem cells / Anat Yanai ... [et al.] -- Generation of megakaryocytes and platelets from human pluripotent stem cells / Marjorie Pick -- Simple protocol for the generation of cardiomyocytes from human pluripotent stem cells / Glen Lester Sequiera, Ashish Mehta, and Winston Shim -- Erratum to: Microgrooved surface modulates neuron differentiation in human embryonic stem cells / David Lu ... [et al.].
- 2016 SpringerNiranjan Bhattacharya, Phillip G. Stubblefield, editors.Part I. Introduction -- Part II. Structural and functional fetal development up to second trimester -- Part III. Gene and human fetal development up to second trimester -- Part IV. Impact of stem cell on growth and development of human fetus -- Part V. Fetal endocrine development up to second trimester -- Part VI. Fetal immune development: up to second trimester -- Part VII. Fetal hepatic development: up to second trimester -- Part VIII. Fetal cardiovascular development: up to second trimester -- Part IX. Fetal neurological development: up to second trimester and its implication in adult neurodegenerative diseases -- Part X. Fetal neuropsychiatric development: up to second trimester -- Part XI. Fetal nephrological development: up to second trimester -- Part XII. Fetal haematological development -- Part XIII. Pharmacological implication of fetal development: up to second trimester -- Part XIV. Surgical implications of fetal development: up to second trimester -- Part XV. Fetal growth and adult life implications -- Part XVI. Understanding fetal growth from the perspective of alternative medicine -- Part XVII. Miscellaneous -- Part XVIII. Ethics and human fetal tissue research.
- 2013 Springereditors, David K. Gardner, Denny Sakkas, Emre Seli, Dagan Wells.
- 2005 Kargervolume editor, Udo R. Markert.Also available: Print – 2005
- Investigating Wnt/ss-catenin signaling in stem cells and progenitors of the developing and adult mouse brain2012Angela N. Bowman.In order for a tissue to be properly sized and patterned, enormous care must be taken to ensure that cell proliferation and differentiation are tightly regulated. The embryonic brain must execute a temporally and spatially defined developmental scheme, resulting in the production of millions of cells of multiple lineages. These cells and their resultant functional architecture must be maintained in the homeostatic adult mouse brain. These processes are in part controlled by external signaling factors, which include Wnts, and their transcriptional programs. However, the degree to which and exact mechanisms by which cell fate choices--including self-renewal, proliferation, and differentiation--are controlled by Wnt/ss-catenin signaling are unknown. Here, I describe studies to investigate these questions. First, I show the identification of a novel target of Wnt/sscatenin signaling, Pou6f1, which mediates neural differentiation and proliferation in embryonic neural progenitor cells. Next, I illustrate the use of a lineage tracing approach using a Wnt/ss-catenin target gene, Axin2, to identify and trace sites of Wnt/ss-catenin responsiveness in the developing and adult mouse brain and central nervous system. Using this same Axin2CreERT2 mouse, I describe the functional consequences of loss of sscatenin from Axin2-expressing cells. Axin2CreERT2 labels numerous radial glial cell populations throughout the central nervous system, three of which serve as functional stem/progenitor populations. Loss of ss-catenin from adult Axin2+ populations results in tissue architecture defects and increased proliferation, presumably because Wnt serves as a self-renewal signal. These studies demonstrate the importance of Wnt/ss-catenin signaling for mediating multiple cell fate choices during the development and homeostasis of the mouse central nervous system, and suggest mechanisms by which neural stem/progenitor populations could be manipulated for therapeutic outcomes.
- 2010T.W. Sadler ; original illustrations by Jill Leland ; computer illustrations by Susan L. Sadler-Redmond ; scanning electron micrographs by Kathy Tosney ; ultrasound images by Nancy Chescheir and Hytham Imseis.Embryology : old and new frontiers and an introduction to molecular regulation and signaling -- Gametogenesis : conversion of germ cells into male and female gametes -- First week of development : ovulation to implantation -- Second week of development : bilaminar germ disc -- Third week of development : trilaminar germ disc -- Third to eighth weeks : the embryonic period -- Third month to birth : the fetus and placenta -- Birth defects and prenatal diagnosis -- Skeletal system -- -- Muscular system -- Body cavities -- Cardiovascular system -- Respiratory system -- Digestive system -- Urogenital system -- Head and neck -- Central nervous system -- Ear -- Eye -- Integumentary system.
- 2015 ClinicalKeyGary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.Gametogenesis, fertilization, and first week -- Second week : becoming bilaminar and fully implanting -- Third week : becoming trilaminar and establishing body axes -- Fourth week : forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and Its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urinary system -- Development of the pharyngeal apparatus and face -- Development of the ears -- Development of the eyes -- Development of the limbs.
- 2009Gary C. Schoenwolf, Steven B. Bleyl, Philip R. Brauer, Philippa H. Francis-West.Gametogenesis, fertilization, and first week -- Second week: becoming bilaminar and fully implanting -- Third week: becoming trilaminar and establishing body axes -- Fourth week: forming the embryo -- Principles and mechanisms of morphogenesis and dysmorphogenesis -- Fetal development and the fetus as patient -- Development of the skin and its derivatives -- Development of the musculoskeletal system -- Development of the central nervous system -- Development of the peripheral nervous system -- Development of the respiratory system and body cavities -- Development of the heart -- Development of the vasculature -- Development of the gastrointestinal tract -- Development of the urogenital system -- Development of the pharyngeal apparatus and face -- Development of the ears and eyes -- Development of the limbs.
- 2013 Springer Protocolsedited by Hayden A. Homer.Studying recombination in mouse oocytes / Xianfei Sun and Paula E. Cohen -- Analysis of recombinants in female mouse meiosis / Esther de Boer, Maria Jasin, and Scott Keeney -- Studying meiosis-specific cohesins in mouse embryonic oocytes / Ji-hye Kim [and others] -- Immunohistochemical approaches to the study of human fetal ovarian development / Jing He [and others] -- Protein kinase assays for measuring MPF and MAPK activities in mouse and rat oocytes and early embryos / Jacek Z. Kubiak -- Time-lapse epifluorescence imaging of expressed cRNA to cyclin B1 for studying meiosis I in mouse oocytes / Janet E. Holt, Simon I.R. Lane, and Keith T. Jones -- Using FRET to study ranGTP gradients in live mouse oocytes / Julien Dumont and Marie-Hélène Verlhac -- Making cRNA for microinjection and expression of fluorescently tagged proteins for live-cell imaging in oocytes / Mark Levasseur -- RNAi-based methods for gene silencing in mouse oocytes / Paula Stein, Petr Svoboda, and Richard M. Schultz -- Micro-injection of morpholino oligonucleotides for depleting securin in mouse oocytes / Petros Marangos -- Measuring transport and accumulation of radiolabeled substrates in oocytes and embryos / Jay M. Baltz, Hannah E. Corbett, and Samantha Richard -- Immunofluorescence staining of spindles, chromosomes, and kinetochores in human oocytes / Solon Riris [and others] -- Studying the roles of aurora-C kinase during meiosis in mouse oocytes / Kuo-Tai Yang [and others] -- Chromosome spreads with centromere staining in mouse oocytes / Jean-Philippe Chambon, Khaled Hached, and Katja Wassmann -- Preparation of mammalian oocytes for transmission electron microscopy / Lynne Anguish and Scott Coonrod -- Measuring Ca2 oscillations in mammalian eggs / Karl Swann -- Counting chromosomes in intact eggs / Teresa Chiang and Michael A. Lampson -- Free-hand bisection of mouse oocytes and embryos / Zbigniew Polanski and Jacek Z. Kubiak -- Microarray-CGH for the assessment of aneuploidy in human polar bodies and oocytes / Souraya Jaroudi and Dagan Wells -- Nuclear transfer in the mouse oocyte / Eiji Mizutani, Atsuo Ogura, and Teruhiko Wakayama.
- 2013 ScienceDirectJamie A. Davies.Morphogenesis is the set of processes that generate shape and form in the embryo--an important area within developmental biology. An exciting and up-to-the-minute account of the very latest research into the factors that create biological form, Mechanisms of Morphogenesis, second edition is a text reference on the mechanisms of cell and tissue morphogenesis in a diverse array of organisms, including prokaryotes, animals, plants and fungi. By combining hard data with computer modeling, Mechanisms of Morphogenesis, second edition equips readers with a much broader understanding of the scope of modern research than is otherwise available. The book focuses on the ways in which the genetic program is translated to generate cell shape, to direct cell migration, and to produce the shape, form and rates of growth of the various tissues. Each topic is illustrated with experimental data from real systems, with particular reference to gaps in current knowledge and pointers to future. Includes over 200 four-color figures. Offers an integrated view of theoretical developmental biology and computer modelling with laboratory-based discoveries. Covers experimental techniques as a guide to the reader. Organized around principles and mechanisms, using them to integrate discoveries from a range of organisms and systems.
- 2012 SpringerMine Ergüven, Takashi Muramatsu, Ayhan Bilir, editors.pt. 1. GENERAL ASPECTS OF MIDKINE -- General Information on Midkine / Takashi Muramatsu -- The Role of Midkine in Neural Development and Patterning / Sheng Yao and Christoph Winkler -- Midkine: A Player in Innate Immunity / Sara L. Nordin and Arne Egesten -- Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition / Yiping Huang and Edward A. Ratovitski -- Immunochemical Methods for the Detection of Midkine in Samples of Human Origin / Stefan Sommerschuh, Michael Kirchner and Nicole Gliese -- Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review / Malgorzata Krzystek-Korpacka and Malgorzata Matusiewicz -- pt. 2. MIDKINE AND INFLAMMATION -- Midkine in Inflammation and Inflammatory Diseases / Nuray Yazıhan, Mehtap Kacar Kocak and Ethem Akcıl -- Rheumatoid Arthritis and Midkine / Hisako Muramatsu, Kiyoko Maruyama and Naoki Ishiguro -- pt. 3. MIDKINE AND THE CARDIOVASCULAR SYSTEM -- Midkine and Heart Failure / Mitsuru Horiba and Kenji Kadomatsu -- Vascular Restenosis and Midkine / Kenji Kadomatsu -- The Potential of MK Through the Renin-Angiotensin System / Tomoki Kosugi and Kenji Kadomatsu -- pt. 4. MIDKINE AND THE NERVOUS SYSTEM -- Midkine and Multiple Sclerosis / Hideyuki Takeuchi -- Midkine Gene Transfer in Brain Infarction / Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita and Yasuhiro Kumai -- Midkine in Psychiatric and Neurodegenerative Diseases / Eiji Shimizu and Daisuke Matsuzawa -- pt. 5. MIDKINE AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGING -- Role of Midkine in Nephrogenesis and Kidney Disease / Waichi Sato and Kenji Kadomatsu -- Midkine, a Factor Promoting Cytoplasmic Maturation of Oocytes / Masayasu Yamada, Yuuki Isaji and Shuntaro Ikeda -- Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles / Yutaka Osuga, Yasushi Hirota, Kaori Koga, Osamu Yoshino and Tetsuya Hirata -- Stem Cells and Midkine / Hisako Muramatsu, Peng Zou and Takashi Muramatsu -- Midkine in Skeletal Physiology / Astrid Liedert, Thorsten Schinke, Anita Ignatius and Michael Amling -- pt. 6. MIDKINE AND CANCER -- Midkine and Chemoresistance in Cancers / Yoshifumi Takei and Kenji Kadomatsu -- A Gene Medicine with the Midkine-mediated Transcriptional Regulation as New Cancer Therapeutics / Masatoshi Tagawa, Kiyoko Kawamura, Ling Yu, Yuji Tada and Kenzo Hiroshima, et al. -- Midkine as a Tumor-Shared Antigen / Jerome Kerzerho, Florence Anne Castelli and Bernard Maillère -- Midkine in Prostate Cancer / Zongbing You -- Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma / Li Cheng Dai, Xing Yao and Jing Zhong -- Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival / Mine Ergüven and Ayhan Bilir -- Colon Cancer and Midkine / Özgür Kemik, Ahu Sarbay Kemik and A. Cumhur Dülger -- Osteosarcoma and Midkine / Tadashi Kaname, Kumiko Yanagi and Hiroki Maehara.
- 2008 Springer Protocolsedited by Paul T. Sharpe and Ivor Mason.The mouse as a developmental model / Paul T. Sharpe -- Culture of postimplantation mouse embryos / Paul Martin and David L. Cockroft -- Organ culture in the analysis of tissue interactions / Irma Thesleff and Carin Sahlberg -- Treatment of mice with retinoids in vivo and in vitro / Gillian M. Morriss-Kay -- Analysis of skeletal ontogenesis through differential staining of bone and cartilage / Michael J. Depew -- Cell grafting and labeling in postimplantation mouse embryos / Gabriel A. Quinlan ... [et al.] -- Production of transgenic rodents by the microinjection of cloned DNA into fertilized one-celled eggs / David Murphy -- Cre recombinase mediated alterations of the mouse genome using embryonic stem cells / Anna-Katerina Hadjantonakis, Melinda Pirity, and András Nagy -- Gene trapping in mouse embryonic stem cells / Jane Brennan and William C. Skarnes -- Application of lacZ transgenic mice to cell lineage studies / Catherine M. Watson ... [et al.] -- Transgenic RNA interference to investigate gene function in the mouse / Tilo Kunath -- Mouse primordial germ cells : isolation and in vitro culture / Patricia A. Labosky and Brigid L.M. Hogan -- Gene transfer to the rodent embryo by retroviral vectors / Marla B. Luskin -- The avian embryo : an overview / Ivor Mason -- Chick embryos : incubation and isolation / Ivor Mason -- New culture / Amata Hornbruch -- EC culture : a method to culture early chick embryos / Andrea Streit -- Grafting Henson's node / Claudio D. Stern -- Microsurgical manipulation of the notochord / Lúcia E. Alvares ... [et al.] -- Transplantation of avian neural tissue / Sarah Guthrie -- Grafting of apical ridge and polarizing region / Cheryl Tickle -- Tissue recombinations in collagen gels / Marysia Placzek -- Quail-chick chimeras / Marie-Aimée Teillet, Catherine Ziller, and Nicole M. Le Douarin -- Using fluorescent dyes for fate mapping, lineage analysis, and axon tracing in the chick embryo / Jonathan D.W. Clarke -- Gene transfer in avian embryos using replication-competent retroviruses / Cairine Logan and Philippa Francis-West -- Electroporation in avian embryos / Jun-ichi Funahashi and Harukazu Nakamura -- An overview of Xenopus development / Michael Jones and James C. Smith -- Mesoderm induction assays / C. Michael Jones and James C. Smith -- Experimental embryological methods for analysis of neural induction in the amphibian / Ray Keller, Ann Poznanski, and Tamira Elul -- A method for generating transgenic frog embryos / Shoko Ishibashi, Kristin L. Kroll, and Enrique Amaya -- Axolotl/newt / Malcolm Maden -- The zebrafish : an overview of its early development / Nigel Holder and Qiling Xu -- Small-scale marker-based screening for mutations in zebrafish development / Peter D. Currie, Thomas F. Schilling, and Philip W. ingham -- Microinjection and cell transplantation in zebrafish embryos / Qiling Xu, Derek Stemple, and Katherine Joubin -- Recent advances in meganuclease- and transposon-mediated transgenesis of medaka and zebrafish / Clemens Grabher and Joachim Wittbrodt -- Retinoids in nonmammalian embryos / Malcolm Maden -- Protochordates / Peter W.H. Holland and Hiroshi Wada -- Subtractive hybridization and construction of cDNA libraries / Bruce Blumberg and Juan Carlos Izpisúa Belmonte -- Differential display of eukaryotic mRNA / Antonio Tugores and Juan Carlos Izpisúa Belmonte -- Using DNA microarrays / Clare Pritchard, Peter Underhill, and Andy Greenfield -- Profiling gene transcription in the developing embryo : microarray analysis on gene chips / David Chambers and Andrew Lumsden -- RT-PCR on embryos using degenerate oligonucleotide primers / Anthony Graham -- Single-cell RT-PCR cDNA subtraction / Ebrahim Sakhinia ... [et al.] -- In-situ hybridization of rdioactive riboprobes to RNA in tissue sections / Radma Mahmood and Ivor Mason -- In-situ hybridization and immunohistochemistry in whole embryos / Carol Irving -- Wholemount in situ hybridization to Xenopus embryos / C. Michael Jones and James C. Smith -- Wholemount in situ hybridization to Amphioxus embryos / Peter W.H. Holland -- In-situ hybridization to sections (nonradioactive) / Maria Rex and Paul J. Scotting -- Immunohistochemistry using polyester wax / Andrew Kent -- Immunohistochemistry on whole embryos / Ivor Mason -- Whole embryo assays for programmed cell death / Anthony Graham -- Protein techniques : immunoprecipitation, in vitro kinase assays, and western blotting / Clive Dickson -- Microscopy and photmicrography techniques / Richard J.T. Wingate.
- 2012 SpringerJacek Z. Kubiak, editor.Post-transcriptional Control of Gene Expression During Mouse Oogenesis / Hugh J. Clarke -- Polarity and Asymmetry During Mouse Oogenesis and Oocyte Maturation / Malgorzata Kloc, Rafik M. Ghobrial, Ewa Borsuk and Jacek Z. Kubiak -- Chromatin Structure and ATRX Function in Mouse Oocytes / Rabindranath De La Fuente, Claudia Baumann and Maria M. Viveiros -- Cyclin B in Mouse Oocytes and Embryos: Importance for Human Reproduction and Aneuploidy / Zbigniew Polański, Hayden Homer and Jacek Z. Kubiak -- Src Protein Kinases in Mouse and Rat Oocytes and Embryos / Mattan Levi, Lihi Ninio-Mani and Ruth Shalgi -- Gradual Meiosis-To-Mitosis Transition in the Early Mouse Embryo / Aurélien Courtois and Takashi Hiiragi -- Maternal Control of Mouse Preimplantation Development / Wenjing Zheng and Kui Liu -- Preimplantation Mouse Embryo: Developmental Fate and Potency of Blastomeres / Aneta Suwińska -- Creation of Trophectoderm, the First Epithelium, in Mouse Preimplantation Development / Yusuke Marikawa and Vernadeth B. Alarcon -- Cell Lineage Allocation Within the Inner Cell Mass of the Mouse Blastocyst / Panagiotis Xenopoulos, Minjung Kang and Anna-Katerina Hadjantonakis -- Formation of Distinct Cell Types in the Mouse Blastocyst / Samantha A. Morris and Magdalena Zernicka-Goetz -- Cell Movements in the Egg Cylinder Stage Mouse Embryo / Bradley Joyce and Shankar Srinivas -- Balancing the Dose in the Mouse / Mary E. Donohoe -- Mouse Oviduct Development / C. Allison Stewart and Richard R. Behringer -- Cell Lineages, Growth and Repair of the Mouse Heart / Fabienne Lescroart and Sigolène M. Meilhac -- Cellular Reprogramming During Mouse Development / Zoë D. Burke, Gabriela Miron-Buchacra and David Tosh -- Differentiation of Definitive Endoderm from Mouse Embryonic Stem Cells / Peter T. W. Kim and Christopher J. Ong -- Mouse and Human Pluripotent Stem Cells and the Means of Their Myogenic Differentiation / I. Grabowska, K. Archacka, A. M. Czerwinska, M. Krupa and M. A. Ciemerych -- Stem Cells and Corneal Epithelial Maintenance: Insights from the Mouse and Other Animal Models / Richard L. Mort, Panagiotis Douvaras, Steven D. Morley, Natalie Dorà and Robert E. Hill, et al. -- Mouse-Induced Pluripotent Stem Cells / Hui Zhang and Ying Jin -- Aging in the Mouse and Perspectives of Rejuvenation Through Induced Pluripotent Stem Cells (iPSCs) / Ken-ichi Isobe, Zhao Cheng, Sachiko Ito and Naomi Nishio.Also available: Print – 2012
- 2014 Springer Protocolsedited by Mark Lewandoski.In situ Hybridization Methods for Mouse Whole Mounts and Tissue Sections with and Without Additional [beta]-galactosidase Staining -- Two Color In Situ Hybridization of Whole-Mount Mouse Embryos -- Detection and Monitoring of MicroRNA Expression in Developing Mouse Brain and Fixed Brain Cryosections -- Laser Capture Microdissection of Embryonic Cells and Preparation of RNA for Microarray Assays -- EMAGE: Electronic Mouse Atlas of Gene Expression -- Real-time PCR Quantification of gene Expression in Embryonic Mouse Tissue -- Identifying Essential Genes in Mouse Development Via an ENU-based Forward Genetic Approach -- Generation of Mouse Embryos with Small Hairpin RNA-mediated Knockdown of Gene Expression -- Generation of Tissue Organoids by Compaction Reaggregation -- Ultra-Rapid Vitrification of Mouse Oocytes and Embryos -- Mammalian Preimplantation Embryo Culture -- Serum-Free Culture of Mid-Gestation Mouse Embryos: A Tool for the Study of Endoderm-Derived Organs -- Genetically Encoded Probes Provide a Window On Embryonic Arrhythmia -- Microscopic Computed Tomography-based Skeletal Phenotyping for Genetic Model Organisms -- Gene Transfer Techniques in Whole Embryo Cultured Post-Implantation Mouse Embryos -- Segmentation and Quantitative Analysis of Individual Cells in Developmental Tissues -- Protein/Peptide Transduction in Metanephric Explant Culture -- Direction of Cells Programmed to Die in Mouse Embroys -- Microscopic Computed Tomography-based ?Virtual Histology of Embryos -- Collection and Preparation of Rodent Embryonic Samples for Transcriptome Study -- The Latest Improvements in the Mouse Sperm Preservation -- Analyzing Gene Function in Whole Mouse Embryo and Fetal Organ in vitro -- Using the Textpresso Site Specific Recombinases Web Server to Identify ?Cre Expressing Mouse Strains and Floxed Alleles -- Live Imaging Mouse Embryonic Development: Seeing is Believing and Revealing -- Genetic Cell Ablation -- Essentials of Recombinase-based Genetic Fate Mapping in Mice.
- 2012 ClinicalKeyLarry R. Cochard ; illustrations by Frank H. Netter ; contributing illustrators, John A. Craig, Carlos A.G. Machado.Here's a rich pictorial review of normal and abnormal human prenatal development. For each body system or region, you'll find a brief description of the developmental plan, with key concepts and terminology, followed by discussions of histological principles, the classification of congenital defects, and basic cellular, molecular, and genetic concepts. An emphasis on morphological patterns in the embryo and fetus makes it easy to understand the structure and function of the adult body and the embryonic basis of birth defects. Summary tables and terminology sections at the end of each chapter, plus an appendix with all major congenital defects and their embryonic basis, make it easy to review course material and prepare for the USMLE.
- 2014 ScienceDirectedited by Paul A. Trainor.This book summarizes discoveries of historical significance and provides in-depth, current analyses of the evolution of neural crest cells, their contribution to embryo development, and their roles in disease. In addition, prospects for tissue engineering, repair and regeneration are covered, offering a timely synthesis of the current knowledge in neural crest cell research.
- 2006 Springeredited by Jean-Pierre Saint-Jeannet.Neural crest cells and the community of plan for craniofacial development : historical debates and current perspectives / Drew M. Noden and Richard A. Schneider -- Neural crest inducing signals / Martin L. Basch and Marianne Bronner-Fraser -- Transcriptional regulation at the neural plate border / Thomas D. Sargent -- Neural crest delamination and migration : integrating regulations of cell interactions, locomotion, survival and fate / Jean-Loup Duband -- Neural crest cell plasticity : size matters / Lisa L. Sandell and Paul A. Trainor -- The contribution of the neural crest to the vertebrate body / Elisabeth Dupin, Sophie Creuzet, and Nicole M. Le Douarin -- Cranial neural crest and development of the head skeleton / Robert D. Knight and Thomas F. Schilling -- Neural crest contribution to the cardiovascular system / Christopher B. Brown and H. Scott Baldwin -- The genetic regulation of pigment cell development / Debra L. Silver, Ling Hou, and William J. Pavan -- Specification of sensory neuron cell fate from the neural crest / David W. Raible and Josette M. Ungos -- Neural crest and the development of the enteric nervous system / Richard B. Anderson, Donald F. Newgreen, and Heather M. Young -- Growth factors regulating neural crest cell fate decisions / Lukas Sommer -- Neural crest stem cells / Lu Teng and Patricia A. Labosky -- Molecular bases of human neurocristopathies / Heather C. Etchevers, Jeanne Amiel, and Stanislas Lyonnet -- Evolution of the neural crest / Alejandro Barrallo-Gimeno and M. Angela Nieto.Also available: Print – 2006
- 2016 SpringerDagmar Wilhelm, Pascal Bernard, editors.1. The reproductive system -- 2. Non-coding RNAs: an introduction -- 3. How many non-coding RNAs does it take to compensate male/female genetic imbalance? -- 4. The piRNA pathway guards the germline genome against transposable elements -- 5. Non-coding RNA in spermatogenesis and epididymal maturation -- 7. Non-coding RNAs in mammary gland development and disease -- 8. Non-coding RNAs in prostate cancer: from discovery to clinical applications -- 9. Non-coding RNAs in uterine development, function and disease -- Index.Also available: Print – 2016
- 2012 Springeredited by Jörg Reichrath, Sandra Reichrath.The Molecular Basis of Notch Signaling: A Brief Overview / Sang-Mo Kwon, Cantas Alev, Sang-Hun Lee and Takayuki Asahara -- The Role of Adams in Notch Signaling / Arjan J. Groot and Marc A. Vooijs -- Metabolism and Transportation Pathways Of GDP-Fucose that are Required for the O-Fucosylation Of Notch / Tomoko Yamakawa, Tomonori Ayukawa and Kenji Matsuno -- Notch Signaling and the Generation of Cell Diversity in Drosophila Neuroblast Lineages / Gerald Udolph -- NEPRO: A Novel Notch Effector for Maintenance of Neural Progenitor Cells in the Neocortex / Tetsuichiro Saito -- Notch Signaling and Development of the Hematopoietic System / Ashley R. Sandy, Morgan Jones and Ivan Maillard -- Notch Signaling in Lung Development and Disease / Keli Xu, Nadeem Moghal and Sean E. Egan -- The Role of Notch Signaling in Kidney Development and Disease / Hila Barak, Kameswaran Surendran and Scott C. Boyle -- Notch Signaling and the Developing Skeleton / Timothy J. Mead and Katherine E. Yutzey -- Notch Signaling and the Developing Skin Epidermis / Daniela Massi and John Panelos -- Notch Signaling and the Developing Hair Follicle / Geneviève Aubin-Houzelstein -- Notch Signaling and the Developing Inner Ear / Junko Murata, Katsuhisa Ikeda and Hideyuki Okano -- Notch Signaling in Cancer Stem Cells / Jialiang Wang, Bruce A. Sullenger and Jeremy N. Rich -- Notch Signaling Pathway and Cancer Metastasis / Yi-Yang Hu, Min-hua Zheng, Rui Zhang, Ying-Min Liang and Hua Han -- Notch, Apoptosis and Cancer / Thao P. Dang -- Ligand-Dependent Notch Signaling in Vascular Formation / Tsutomu Kume -- Notch and the p53 Clan of Transcription Factors / Klaus Roemer -- Notch Signaling and Breast Cancer / Michael Reedijk -- Notch Signaling and Malignant Melanoma / Cornelia S. L. Müller -- Notch-Signaling and Nonmelanoma Skin Cancer: An Ancient Friend, Revisited / Jörg Reichrath and Sandra Reichrath -- Notch Signaling and Intestinal Cancer / Sandra Guilmeau -- Notch Signaling and Brain Tumors / Marie-Thérése Stockhausen, Karina Kristoffersen and Hans Skovgaard Poulsen -- Notch Inhibition as a Promising New Approach to Cancer Therapy / Benjamin Purow.Also available: Print – 2012
- 2013 SpringerGiovanni Coticchio, David F. Albertini, Lucia De Santis, editors.The oocyte is the largest and most mysterious cell in the body of mammalian organisms. Through its growth and maturation, it reaches extreme levels of specialization, while maintaining at the same time a condition of totipotency. Its unique ability, in co-operation with the spermatozoon, to give rise to a fully developed organism formed from hundreds of different tissues and myriads of individual cells has inspired intellectuals of all ages.Oogenesis finds impetus and purpose in casting scientific perspective towards this unique cell for the benefit of scientists and assisted reproductive technology (ART) specialists. The authors of the chapters are distinguished authorities in their respective areas of competence. From the opening of the book the reader is lead on a fantastic voyage from the formation of the primordial oocyte to the development of the early embryo, passing through crucial processes of oogenesis, such as co-ordination of oocyte and follicle growth, gene expression and organelle reorganization during growth and maturation, epigenetic mechanisms, regulation of meiosis, totipotency, cell polarity, oogenesis in vitro and maternal regulation of early development.
- 2011 Springer Protocolsedited by Trevor A. Thorpe and Edward C. Yeung.Zygotic embryo culture : an overview / Tegan M. Haslam and Edward C. Yeung -- In vitro fertilization with rice gametes: production of zygotes and zygote and embryo culture / Takashi Okamoto -- Canola zygotic embryo culture / Nicole S. Ramesar-Fortner and Edward C. Yeung -- Immature seeds and embryos of Medicago truncatula cultured in vitro / Sergio J. Ochatt -- In vitro culture and germination of terrestrial asian orchid seeds / Yung-I. Lee -- In vitro culture of coconut (Cocos nucifera L.) zygotic embryos / Florent Engelmann, Bernard Malaurie, and Oulo N'Nan -- Immature embryo rescue and culture / Xiuli Shen, Fred G. Gmitter, Jr., and Jude W. Grosser -- Chickpea hybridization using in vitro techniques / Nalini Mallikarjuna and Fred J. Muehlbauer -- Muskmelon embryo rescue techniques using in vitro embryo culture / Hector Gordon Nunez-Palenius, Rafael Ramirez-Malagon, and Neftali Ochoa-Alejo -- Phaseolus immature embryo rescue technology / Pascal Geerts ... [et al.] -- Wide crossing in lentil through embryo rescue / Richard Fratini and Maria L. Ruiz -- Generation of interspecific hybrids of Trifolium using embryo rescue techniques / Ajoy Kumar Roy, Devendra Ram Malaviya and Pankaj Kaushal -- Cryopreservation of embryos : an overview / Florent Engelmann -- Cryogenic technologies for the long-term storage of Citrus germplasm / Anna De Carlo, Maurizio Lambardi, and Elif Aylin Ozudogru -- Cryopreservation of zygotic embryonic axes and somatic embryos of european chestnut / Ana M. Vieitez, M. Carmen San-Jose and Elena Corredoira -- Cryopreservation of Ilex immature zygotic embryos / Luis Mroginski ... [et al.] -- Use of zygotic embryos as explants for in vitro propagation : an overview / Mohamed Elhiti and Claudio Stasolla -- Somatic embryogenesis and plant regeneration in the culture of Arabidopsis thaliana (L.) heynh. immature zygotic embryos / Malgorzata D. Gaj -- Pine somatic embryogenesis using zygotic embryos as explants / Gerald S. Pullman and Kylie Bucalo -- Micropropagation of Phalaenopsis orchids via protocorms and protocorm-like bodies / Kee Yoeup Paek, Eun Joo Hahn, and So Young Park -- Genetic transformation protocols using zygotic embryos as explants : an overview / Muhammad Tahir, Ejaz A. Waraich, and Claudio Stasolla -- Genetic transformation using maize immature zygotic embryos / Bronwyn Frame ... [et al.] -- Biolistic-mediated transformation protocols for maize and pearl millet using pre-cultured immature zygotic embryos and embryogenic tissue / Martha M. O'Kennedy, Hester C. Stark and Nosisa Dube -- Agrobacterium tumefaciens-mediated genetic transformation of cereals using immature embryos / Ashok K. Shrawat and Allen G. Good.
- 2013 SpringerTiziana A.L. Brevini, Fulvio Gandolfi.This addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.
- 2014 SpringerPeter Sutovsky, editor.Sperm proteases and extracellular ubiquitin-proteasome system involved in fertilization of ascidians and sea urchins -- ISGylation: a conserved pathway in mammalian pregnancy -- Src-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective -- Posttranslationally modified tubulins and other cytoskeletal proteins: their role in gametogenesis, oocyte maturation, fertilization and pre-implantation embryo development -- Deubiquitinating enzymes in oocyte maturation, fertilization and preimplantation embryo development -- Posttranslational modifications of zona pellucida proteins -- Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes -- Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control -- Ubiquitin-proteasome system in spermatogenesis -- Role of posttranslational modifications in C. elegans and Ascaris spermatogenesis and sperm function.Also available: Print – 2014
- 2013 SpringerMark V. Sauer, editor.The versatility of oocyte and embryo donation has proven to be extremely valuable to both patients and doctors engaged in reproductive medicine. Originally thought to be applicable only to a rather small subset of infertile women, today busy practices commonly recommend the procedure and it is estimated that nearly all of the 400 or more IVF programs in the United States provide these services. Oocyte and embryo donation has established itself as a mainstay procedure within assisted reproductive care, and the breadth, depth and complexity of practice is deserving of focused attention. Much has changed within the field of oocyte and embryo donation since the publication of the first edition of Principles of Oocyte and Embryo Donation in 1998, thus the need for a completely updated and more expansive text. The second edition of this book provides an overview of the major issues affecting men and women engaged in the practice of oocyte and embryo donation. A primary emphasis has been placed on defining the standards of practice that have evolved over the past 30 years, clearly stating the outcomes expected from adhering to these established protocols. Details of both the basic science and the clinical medicine are presented together and attention is also focused on the non-reproductive aspects inherent to this unique method of assisted reproduction that involves opinions from lawyers, ethicists, mental health care professionals and theologians. Oocyte and embryo donation requires a working knowledge of the medicine, the law and the ethics that underlies its foundation. This book is intended to serve as a complete and comprehensive reference for all health care professionals that provide services related to egg donation, reproductive endocrinologists, obstetrician- gynecologists, and fellows and residents entering the fertility field.
- Regulation of adult stem cell function and identity by a histone variant and polycomb group proteins in the drosophila testis2012Jose Rafael Morillo Prado.Many adult tissues with short-lived cells such as blood and skin require a constant replacement of aging cells. This process is often accomplished by adult stem cells, both self-renew and give rise to differentiating progeny. The process of self-renewal and differentiation must be tightly controlled: failure to self-renew results in the loss of the stem cell population, and lack of differentiation impairs tissue function with dire consequences to the organism. The fate decisions of stem cells are guided by the interaction between extracellular signals from the local microenvironment and intrinsic factors that set the state of the cell, many of which are coordinated by transcriptional programs that are, in turn, is controlled by posttranslational modifications of histones or replacement of canonical histones with histone variants. Polycomb group (PcG) proteins partake in the modification of histones and influence the transcriptional state of genes. PcG proteins are involved in transcriptional regulation by inducing the methylation and ubiquitination of histone tails, which maintain the repression of target genes through cell divisions. Emerging evidence indicates that replacement of canonical histones with histone variants is also important in cell fate decisions. Here I show that PcG proteins Psc and Su(z)2 restrict proliferation and maintain the identity of the cyst stem cell (CySC) lineage in the Drosophila testis. Loss of Psc and Su(z)2 gene function in CySC but not in the germline stem cell (GSC) lineage resulted in the formation of a tumor composed of proliferative mutant cells of abnormal identity, likely due to the derepression of the Hox gene Abdominal-B. The resulting formation of tumor-like masses of proliferative cells interfered non-cell autonomously with maintenance of the germline most likely by displacing GSCs from their niche. I also show that the histone variant His2Av is required cell-autonomously for maintenance of adult stem cells in both somatic and germ cell lineages. GSCs lacking His2Av function were lost over time. Surprisingly, GSCs null mutant for His2Av gave rise to germ cells that underwent normal transit amplification divisions and differentiation to spermatocytes and spermatids. Similarly, CySCs lacking His2Av were also lost over time, but were able to give rise to differentiated cyst cells. My results indicate that His2Av and Stat92E likely maintain GSCs and CySCs independently. His2Av mutant GSCs expressed Stat92E and had properly oriented centrosomes, while Stat92E mutant GSCs expressed His2Av. My results expand knowledge chromatin states required for adult stem cell function, showing, for the first time, that a histone variant has a unique role in maintaining stem cells.
- 2015 SpringerE. Scott Sills, editor.The Development of PGD -- Elements of Informed Consent for Preimplantation Genetic Diagnosis -- Follicular Recruitment & Oocyte Recovery in Assisted Reproduction -- Biomarker-based Flow-Cytometric Semen Analysis for Male Infertility Diagnostics and Clinical Decision Making in ART -- Comparison of Methods for Assessment of Sperm DNA Damage (Fragmentation) and Implications for the Assisted Reproductive Technologies -- Tweaking ICSI for a PGD program -- Comprehensive Chromosomal Screening from Polar Body Biopsy to Blastocyst Trophectoderm Sampling: Evidence and Considerations -- Polar Body Diagnosis -- An Alternative and Addition to Preimplantation Diagnosis -- Efficiency of Polar Body Biopsy for Aneuploidy Screening by DNA Microarray for Single Embryo Transfer -- Prediction of Embryo Viability by Morphokinetic Evaluation to Facilitate Single Transfer -- Comparison of PCR Techniques for Embryo Screening and Single Embryo Transfer -- Array CGH and Partial Genome Sequencing for Rapidly Karyotyping IVF Blastocysts Before Transfer -- Single Embryo Transfers Enabled by aCGH -- Current and Future Methodologies -- SNP array, qPCR, and next-generation sequencing based comprehensive chromosome screening -- Expanding PGD Applications to Non-traditional Genetic and Non-Genetic Conditions -- Should molecular cytogenetic techniques be applied to facilitate single embryo transfer in egg donation cases? Assessment of frequency and distribution of embryo aneuploidy after anonymous donor oocyte IVF -- Selecting the Single Embryo for Transfer in Mitochondrial Disorders -- Single Embryo Transfer: The Significance of the Embryo Transfer Technique -- The Vitrification Component: An Integral Part of a Successful eSET Program -- A Review of Luteal Support Protocols for Single Embryo Transfers -- Fresh and Frozen -- Cost effectiveness of single embryo transfers relative to higher embryo transfer policies in clinical practice: A population based analysis -- The Quebec experience -- One plus one equals two at once: Presenting cumulative pregnancy rates as the ideal outcome in elective SET programs -- Single Embryo Transfer in a State-Sponsored IVF Context: Current Experience from Israel -- Single Embryo Transfer: the Quebec Experience -- Regulatory Aspects of Embryo Testing: An American View -- Regulatory Challenges in Assisted Reproduction: A European Perspective -- Preimplantation Genetic Screening: Ethics & Policy -- Crossing Rubicons: Assisted Reproductive Therapies and Remaining Human.
- 2007 Springer Protocolsedited by Mohan C. Vemuri.Derivation of human embryonic stem cells in xeno-free conditions / Mohan C. Vemuri ... [et al.] -- Feeder-layer free culture system for human embryonic stem cells / Michal Amit -- Digital imaging of stem cells by electron microscopy / A. Henry Sathananthan and Stefania A. Nottola -- A controlled-cooling protocol for cryopreservation of human and non-human primate embryonic stem cells / Carol B. Ware and Szczepan W. Baran -- Cell surface markers in human embryonic stem cells / Raj R. Rao, Alison Venable Johnson, and Steven L. Stice -- Generation of a monoclonal antibody library against human embryonic stem cells / Micha Drukker, Christina Muscat, and Irving L. Weissman -- Analytical methods for cancer stem cells / Vinagolu K. Rajasekhar -- Micro RNA profiling : an easy and rapid method to screen and characterize stem cell populations / Uma Lakshmipathy ... [et al.] -- Gene transfer via nucleofection into adult and embryonic stem cells / Uma Lakshmipathy, Shannon Buckley, and Catherine Verfaillie -- RNAi knockdown of transcription factor Pu.1 in the differentiation of mouse embryonic stem cells / Gang-Ming Zou, Meredith A. Thompson, and Mervin C. Yoder -- StemBase : a resource for the analysis of stem cell gene expression data / Christopher J. Porter ... [et al.] -- Isolation of stem cells from human umbilical cord blood / Nishanth P. Reddy, Mohan C. Vemuri, and Reddanna Pallu -- Ex vivo expansion of hematopoietic stem cells from human cord blood in serum-free conditions / Chao-Ling Yao and Shiaw-Min Hwang -- Hematopoietic colony-forming cell assays / Carla Pereira, Emer Clarke, and Jackie Damen -- Assays for alloreactive responses by PCR / Patrick Stordeur -- Immune properties of mesenchymal stem cells / Panagiota A. Sotiropoulou and Michael Papamichail -- Clinical grade expansion of human bone marrow mesenchymal stem cells / Panagiota A. Sotiropoulou, Sonia A. Perez, and Michael Papamichail -- Adenoviral transduction of mesenchymal stem cells / Pablo Bosch and Steven L. Stice -- Directed differentiation of human embryonic stem cells to dendritic cells / Maxim A. Vodyanik and Igor I. Sluvkin -- Insulin-producing cells from embryonic stem cells to dendritic cells / Maxim A. Vodyanik and Igor I. Slukvin -- Insulin-producing cells from embryonic stem cells experimental considerations / Enrique Roche ... [et al.] -- Efficient generation of dopamine neurons from human embryonic stem cells / Chang-Hwan Park and Sang-Hun Lee -- Isolation of oligodendroglial cells from cultured neural stem/progenitors / Frank Zeigler and Stephen G. Hall -- Differentiation of human embryonic stem cells toward the chondrogenic lineage / Wei Seong Toh ... [et al.] -- Cartilage tissue engineering : directed differentiation of embryonic stem cells in three-dimensional hydrogel culture / Nathaniel S. Hwang, Shyni Varghese, and Jennifer Elisseeff.
- 2008 ScienceDirectedited by Jennie P. Mather.Also available: Print – 2008
- 2015 ProQuest Ebook CentralSheldon Krimsky.Employing a series of Socratic dialogues, this study of the use of stem cells in medicine and medical research examines the ethical and public policy issues that confront scientists, clinicians, and the public health community.
- 2013 SpringerStewart Sell, editor.Stem Cells Handbook, second edition, emphasizesthe advances in understanding and working with embryonic and fetal stem cells as well as induced pluripotent stem cells that show the most promise for clinical use. This new edition has been completely rewritten and updated to reflect the significant advances made in this field since publication of the first edition in 2004. The thirty-six chapters in this book all written by recognized experts in Stem Cell research reflect the tremendous progress in the understanding of stem cell biology and the appreciation of the potential for using stem cells for therapy of cancer, aging, injury and congenital diseases. Arguably the biggest advances have been made in obtaining different populations of stem cells, inducing mature cells to act like stem cells, and the ever-critical issue of how to get these stem cells to expand and differentiate into the tissue precursor cells that then can be used to replace lost of damaged tissues. No less exciting are the recent advances in understanding how stem cells function to maintain tissue integrity and how to use this knowledge to prevent developmental abnormalities. Other key topics discussed include: properties of tissue stem cells, transplantation of stem cells, the stem cell as a target for cancer treatment and prevention.
- 2012Xiaohu Ouyang.Embryonic development and tissue regeneration are regulated by complex genetic programs that are dynamically executed in a stereotypic manner, and deciphering these molecular mechanisms requires the ability to control gene function with spatial and temporal precision. Synthetic chemistry has been increasingly used to create reagents that can enable such genetic manipulations. In this thesis I describe the development and application of caged morpholino (cMO) oligonucleotides and small molecules to study zebrafish embryonic development and larvae tail regeneration. In Chapter 1, we survey how chemical tools and engineered proteins have been used to perturb developmental processes at the DNA, RNA, protein, and cellular levels. We discuss the design principles, experimental capabilities, and limitations of each method, as well as future challenges for the chemical and developmental biology communities. In Chapter 2, we describe optimized methods for the design and synthesis of hairpin cMO oligonucleotides incorporating a dimethoxynitrobenzyl (DMNB)-based bifunctional linker that permits cMO assembly in only three steps from commercially available reagents. Using this simplified procedure, we have systematically prepared cMOs with differing structural configurations and investigated how the in vitro thermodynamic properties of these reagents correlate with their in vivo activities. Through these studies, we have established general principles for cMO design and successfully applied them to several developmental genes. Our optimized synthetic and design methodologies have also enabled us to prepare a next-generation cMO that contains a bromohydroxyquinoline (BHQ)-based linker for two-photon uncaging. Collectively, these advances establish the generality of cMO technologies and will facilitate the application of these chemical probes in vivo for functional genomic studies. In Chapter 3, I first describe our genome-wide microarray analysis and whole-mount in situ hybridization studies that led us to the identification of 18 genes, including hyaluronan synthase 3 (has3), that were expressed during zebrafish larvae tail regeneration. I also report the functional studies of hyaluronan (HA) synthesis using small molecule inhibitor 4-methylumbelliferone (4-MU), in which we showed that 4-MU inhibited tail regeneration by preventing injury-induced cell proliferation. In addition, 4-MU also reduced the expressions of dlx5a and junbb, markers of the wound epithelium and blastema-like mesenchymal cells. We also illustrated that simultaneous dosing of Gsk3[beta] inhibitor BIO and 4-MU could rescue the 4-MU-induced regeneration defects. Our results indicated that the crosstalk between hyaluronan synthesis and Gsk3[beta] signaling played an important role in regulating tail regeneration.
- 2013 Springer Protocolsedited by Paul C. Barrow.ICH S5(R2) guideline for the testing of medicinal agents / L. David Wise -- Nonclinical reproductive toxicity testing requirements for drugs, pesticides, and industrial chemicals in India and China / K.S. Rao and Jing Dong -- Developmental toxicity testing of biologics / Keith P. Hazelden -- OECD guidelines for the testing of chemicals and pesticides / Jochen Buschmann -- Teratology testing under REACH / Steve Barton -- Teratology testing of food additives / Paul C. Barrow and Francois Spezia -- Developmental toxicity testing of vaccines / Paul C. Barrow and Linda Allais -- Teratology testing of cosmetics / Francois Spézia and Paul C. Barrow -- Teratology studies in the rat / Mariline Leroy and Linda Allais -- Teratology studies in the mouse / Edward Marsden and Mariline Leroy -- Combined fertility and embryotoxicity study / Lucie Reynaud and Edward Marsden -- Teratology studies in the rabbit / Linda Allais and Lucie Reynaud -- Teratology studies in the minipig / Peter A. McAnulty -- Embryo fetal development studies in nonhuman primates / Antje Fuchs, Eberhard Buse, and Gerhard F. Weinbauer -- Enhanced pre- and postnatal development study for monoclonal antibodies / Gerhard F. Weinbauer, Joerg Luft, and Antje Fuchs -- Skeletal examination by alizarin staining / Lucie Reynaud and Audrey Jocteur-Monrozier -- Skeletal examination by double staining for ossified bone and cartilaginous tissue / Steffen Schneider -- Small animal imaging and examination by micro-CT / Sergio X. Vasquez, Neha Shah, and Alan M. Hoberman -- Fetal soft tissue examination by serial sectioning / Karon Critchell -- Fetal soft tissue examinations by microdissection / Mariline Leroy and Audrey Jocteur-Monrozier -- Soft tissue examination of the fetal rat and rabbit head by magnetic resonance imaging / Julian M. French and Neil Woodhouse -- Historical control data in reproductive and developmental toxicity studies / Eve Mylchreest and Stephen B. Harris -- Reporting of teratology studies / Paul C. Barrow and Lucie Reynaud -- Maternal toxicity / Bengt R. Danielsson -- Innovations in testing strategies in reproductive toxicology / Aldert H. Piersma -- Predictive models and computational toxicology / Thomas Knudsen, Matthew Martin, Kelly Chandler, Nicole Kleinstreuer, Richard Judson, and Nisha Sipes -- Embryonic stem cell test / Sjors H.W. Schulpen and Aldert H. Piersma -- Zebrafish teratogenicity testing / Kimberly C. Brannen, Jeffrey H. Charlap, and Elise M. Lewis -- Frog embryo teratogenesis assay on Xenopus and predictivity compared with in vivo mammalian studies / Isabelle Leconte and Isabelle Mouche -- Rat whole embryo culture assay using the dysmorphology score system / Cindy Zhang, Julie Panzica-Kelly, and Karen Augustine-Rauch -- Toxicogenomic approaches in developmental toxicology testing / Joshua F. Robinson and Aldert H. Piersma -- Validation of alternative tests for developmental and reproductive toxicology testing : an ILSI Health and Environmental Sciences Institute perspective / James H. Kim -- Regulatory assessment of reproductive toxicology data / Elizabeth Davidson -- Hazard and risk assessment of teratogenic chemicals under REACH / Wiebke Prutner -- Reproductive toxicity risk assessment for pesticides / Beate Ulbrich -- Thalidomide disaster, lessons from the past / James E. Ridings.
- 2013 Cambridgeedited by Kevin Coward, Dagan Wells."The success of Assisted Reproductive Technology is critically dependent upon the use of well optimized protocols, based upon sound scientific reasoning, empirical observations and evidence of clinical efficacy. Recently, the treatment of infertility has experienced a revolution, with the routine adoption of increasingly specialized molecular biological techniques and advanced methods for the manipulation of gametes and embryos. This textbook - inspired by the postgraduate degree program at the University of Oxford - guides students through the multidisciplinary syllabus essential to ART laboratory practice, from basic culture techniques and micromanipulation to laboratory management and quality assurance, and from endocrinology to molecular biology and research methods. Written for all levels of IVF practitioners, reproductive biologists and technologists involved in human reproductive science, it can be used as a reference manual for all IVF labs and as a textbook by undergraduates, advanced students, scientists and professionals involved in gamete, embryo or stem cell biology"--Provided by publisher.
- 2015 CambridgeKay Elder, Marc Van den Bergh, Bryan Woodward.Introduction -- Quality control, certification and accreditation -- The IVF culture system -- Osmometry -- pH regulation in gamete and embryo culture systems -- Temperature control in the IVF laboratory -- The effect of light on embryos and embryo culture -- Gases, air quality and volatile organic carbons (VOCs) -- Infections in IVF culture -- Troubleshooting a cryopreservation system -- Troubleshooting ICSI procedures -- Managing risk in an IVF lab -- Index.
- 2011[authors, James White, Jack Wilson ; contributor, David Seiden].Section I. Histology and Cell Biology -- Section II. Early Embryology -- Section III. Gross Anatomy -- Section IV. Neuroscience -- Index.
- 2017 SpringerFrancisco Pelegri, Michael Danilchik, Ann Sutherland, editors."This book provides a comprehensive overview of topics describing the earliest steps of fertilization, from egg activation and fertilization to the activation of the zygotic genome, in various studied vertebrate model systems. The contribution of maternal and paternal factors and their role in the early embryo as parental DNA becomes modified and embryonic genes become activated is fundamental to the initiation of embryogenesis in all animal systems. It can be argued that this is a unique developmental period, when information from the parents is compressed to direct the development of the body plan of the entire organism, a process of astounding simplicity, elegance and beauty. In addition to their fundamental scientific interest, many frontiers of biomedicine, such as reproductive biology, stem cells and reprogramming, and the understanding of intergenerational diseases, depend on advances in our knowledge of these early processes. Vertebrate Development: Maternal to Zygotic Control brings together chapters from experts in various disciplines describing the latest advances related to this important developmental transition. Each chapter is a synthesis of knowledge relevant to all vertebrates, with details on specific systems as well as comparisons between the various studied vertebrate models. The editorial expertise encompasses the fields of major vertebrate model systems (mammalian, amphibian and teleost) ensuring a balanced approach to various topics. This unique book&with its combination of in-depth and up-to-date basic research, inter-species comprehensiveness and emphasis on the very early stages of animal development&is essential for research scientists studying vertebrate development, as well as being a valuable resource for college educators teaching advanced courses in developmental biology"--Publisher's description.Also available: Print – 2017
- 2011 Springer Protocolsedited by Francisco J. Pelegri.Approaches and species in the history of vertebrate embryology / Nick Hopwood -- Manipulating and imaging the early Xenopus laevis embryo / Michael V. Danilchik -- Manipulation of gene function in Xenopus laevis / Mizuho S. Mimoto and Jan L. Christian -- Developmental genetics in Xenopus tropicalis / Timothy J. Geach and Lyle B. Zimmerman -- Embryological and genetic manipulation of chick development / Laura S. Gammill and Catherine E. Krull -- Embryological manipulations in zebrafish / Yuhua Sun, Dorota Wloga, and Scott T. Dougan -- Practical approaches for implementing forward genetic strategies in zebrafish / Sreelaja Nair and Francisco J. Pelegri -- Essential techniques for introducing medaka to a zebrafish laboratory -- towards the combined use of medaka and zebrafish for further genetic dissection of the function of the vertebrate genome / Sean R. Porazinski, Huijia Wang, and Makoto Furutani-Seiki -- Ex utero culture and live imaging of mouse embryos / Anna Piliszek, Gloria S. Kwon, and Anna-Katerina Hadjantonakis -- Detection of gene expression in mouse embryos and tissue sections / Edwina McGlinn and Jennifer H. Mansfield -- Gene targeting in the mouse / Anne E. Griep [and others] -- Creating a "hopeful monster" : mouse forward genetic screens / Vanessa L. Horner and Tamara Caspary -- Assisted reproductive technology in nonhuman primates / Tien-cheng Arthur Chang and Anthony W.S. Chan -- Embryological methods in ascidians : the Villefranche-sur-Mer protocols / Christian Sardet [and others] -- Ciona genetics / Michael T. Veeman, Shota Chiba, and William C. Smith -- Analyses of gene function in Amphioxus embryos by microinjection of mRNAs and morpholino oligonucleotides / Linda Z. Holland and Takayuki Onai -- Reptile embryology / Matthew K. Vickaryous and Katherine E. McLean -- Reproductive and developmental manipulation of the marsupial, the tammar wallaby Macropus eugenii / Marilyn B. Renfree and Andrew J. Pask -- Mutant generation in vertebrate model organisms by TILLING / Sylke Winkler, Nicola Gscheidel, and Michael Brand -- Inducing high rates of targeted mutagenesis in zebrafish using zinc finger nucleases (ZFNs) / Jasmine M. McCammon, Yannick Doyon, and Sharon L. Amacher -- Derivation of mouse embryonic stem cell lines from blastocysts produced by fertilization and somatic cell nuclear transfer / Zhongde Wang -- Cloning mice and ES cells by nuclear transfer from somatic stem cells and fully differentiated cells / Zhongde Wang -- Keeping two animal systems in one lab -- a frog plus fish case study / Hazel Sive -- Laboratory guidelines for animal care / Marcelo Couto.
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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.
Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence. Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.
Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.
Includes cited reference searching, citation maps, and an analyze tool.
Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.
Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.
Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.
In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.
A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.
Over 10,000 notes outline the status of specific infections within each country.
Provides online, full-text access to Springer's journal titles as well as journals from other publishers.
Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.