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Drug TherapyAccess restricted to Stanford unless otherwise noted

  • Nursing Process Guidelines -- Patient Safety and Medication Administration -- Pharmacologic Classes -- Alphabetical Listing of Drugs by Generic Name.
  • Adverse drug reactions 2010, Springer
    Pt. 1. Target organ toxicity. -- Drug-induced liver injury / Michael Holt, Cynthia Ju.-- Drug herpersensitivity reactions involving skin / Oliver Hausmann, Benno Schnyder, Werner J. Pichler.-- Adverse drug reactions affecting blood cells / Richard H. Aster.-- Molecular mechanisms of adverse drug reactions in cardiac tissue / Reza Tabrizchi.-- Mechanisms of drug-induced nephrotoxicity / Thomas D. Nolin, Jonathan Himmelfarb.-- Receptor- and reactive intermediate-mediated mechanisms of teratogenesis / Peter G. Wells, Crystal J.J. Lee, Gordon P. McCallum, Julia Perstin, Patricia A. Harper.-- Pt. II. Mediators/Biochemical pathways.-- Role of reactive metabolites in drug-induced hepatotoxicity / A.M. Srivastava, J. L. Maggs, D. J. Antoine, D. P. Williams, D. A. Smith, B. K. Park.-- Role of cytokines in the mechanism of adverse drug reactions / Mary Jane Masson, Lindsay A. Collins, Lance R. Poh.-- Keap1-Nrf2 cellular defense pathway: mechanisms of regulation and role in protection against drug-induced toxicity / Ian M. Copple, Christopher E. Goldring, Neil R. Kitteringham, B. Kevin Park.-- Signal transduction pathways involved in drug-induced liver injury / Derick Han, Mie Shinohara, Maria D. Ybanez, Behnam Saberi, Neil Kaplowitz.-- Mictrochondrial involvement in drug-induced liver injury / Dominique Pessayre, Abdellah Mansouri, Alain Berson, Bernard Fromenty.-- Pt. III. Examples/Models.-- Mechanisms of acetaminophen-induced liver necrosis / Jack A. Hinson, Dean W. Roberts, Laura P. James.-- Drug-induced liver injury in humans: the case of Ximelagtran / M. Keisu, T.B. Andersson.-- Troglitazone / Tsuyoshi Yokoi.-- Neviropine hypersensitivity / M. Popovic, J.M. Shenton, J. Chen, A. Baban, T. Tharmanathan, B. Mannargudi, D. Abdulla, J.P. Uetrecht.-- Mechanisms of adverse drug reactions to biologics / Janet B. Clarke.-- Pt. IV. Risk factors/Screening drug candidates.-- Pharmacogenetics of idiosyncratic adverse drug reactions / Munir Pirmohamed.-- Danger hypothesis applied to idiosyncratic drug reactions / Jinze Li, Jack P. Uetrecht.-- Approaches for minimizing metabolic activation of new drug candidates in drug discovery / Sanjeev Kumar, Kaushik Mitra, Kelem Kassahun, Thomas A. Baillie.
  • AIDS therapy. 3rd ed. 2008, ClinicalKey
    AIDS treatments continues to evolve. Now, so does the definitive reference on this complex and challenging subject. "AIDS Therapy, 3rd Edition" not only brings you comprehensive guidance on the latest treatments for HIV/AIDS and the full range of related disorders and syndromes, but also comes with access to updates online--so you can always tap into the most current therapy guidelines. Written by a "who's who" of leading global experts, the new edition of this classic reference is a must for any clinician who manages patients with HIV/AIDS. The most comprehensive coverage available on AIDS treatment equips you to meet any clinical challenge. Contributions from a large cast of noted international authorities put global "best practices" at your fingertips. Advice from some of the most respected experts in the field helps you manage your patients confidently.
  • Aloes 2004, CRCnetBASE
    Aloe vera in thermal and frostbite injuries / Michael K. Obeng J., Gary D. Motykie, Robert L. McCauley and P. Heggers -- Plant saccharides and the prevention of sun-induced skin cancer / Faith M. Strickland and Ronald P. Pelley -- Aloes and the immune system / Ian R. Tizard and Lalitha Ramamoorthy -- Bioactivity of A. arborescens preparations / Akira Yagi -- Aloe biology: the chromosomes of aloe : variation on a theme / Peter Brandham -- Aloe leaf anatomy / David F. Cutler -- Pests of aloes / Monique S.J. Simmonds.The Plants : aloes in habitat / Leonard E. Newton -- Taxonomy of Aloaceae / Gideon F. Smith and Elsie M.A. Steyn -- Aloe constituents : aloe chemistry / Tom Reynolds -- Aloe polysaccharides / Yawei Ni, Kenneth M.Yates and Ian R. Tizard -- Aloe lectins and their activities / Hiroshi Kuzuya, Kan Shimpo and Hidehiko Beppu -- Analytical methodology : the gel analysis of aloe pulp and its derivatives / Yawei Ni and Ian R. Tizard -- Analytical methodology : the exudate / Tom Reynolds -- Industrial processing and quality control of A. barbadensis / Ronald P. Pelley, Todd A. Waller and Faith M. Strickland -- Therapeutic activity of aloes: healing powers of aloes / Nicola Mascolo, Angelo A. Izzo, Francesca Borrelli, Giulia di Carlo, Lidia Sautebin and Francesco Capasso -- Aloe vera in wound healing / Gary D. Motykie and John P. Heggers.
  • Analgesia 2007, Springer
    Part I. Introduction --Peripheral and central mechanism of pain generation /H.G. Schaible --Part II.Drugs in clinical use --Opioids /C. Zöllner, C. Stein --Antipyretic analgesics: nonsteroidal antiinflammatory drugs, selective COX-2 inhibitors, paracetamol and pyrazolionones /B. Hinz, K. Brune --Local anesthetics /R. Yanagidate, G.R. Strichartz --Serotonin receptor ligands: treatments of acute migraine and cluster headache /P.J. Goadsby --Anti-convulsants and anti-depressants /A.H. Dickenson, J. Ghandehari --Part III.Compounds in preclinical development --Neuropeptide and kinin antagonists /R. G. Hill, K.R. Oliver --Glutamate receptor ligands /V. Neugebauer --Adrenergic and cholinergic compounds /R. D. Sanders, M. Maze --Cannabinoids and pain /I.J. Lever, A.S.C. Rice --Part IV.Future targets in analgesia research --Adenosine and ATP receptors /J. Sawynok --Ion channels in analgesia research /J.N. Wood --Protein kinases as potential targets for the treatment of pathological pain /R. R. Ji, Y. Kawasaki, Z. Y. Zhuang, Y.R. Wen, Y.Q. Zhang --Part V.Pain Management beyond pharmacotherapy --Placebo and endogenous mechanisms of analgesia /F. Bededetti --Limitations of pharmacotherapy: behavioral approaches to chronic pain /H. Flor, M. Diers --Subject index.
  • 1. Historical introduction -- 2. Modes of action -- 3. The problem of resistance -- 4. Pharmacodynamics of anti-infective agents: target delineation and susceptibility breakpoint selection -- 5. Antimicrobial agents and the kidneys -- 6. Drug interactions involving anti-infective agents -- 7. Antibiotics and the immune system -- 8. General principles of antimicrobial chemotherapy -- 9. Laboratory control of antimicrobial therapy -- 10. Principles of chemop rophylaxis -- 11. Antibiotic policies -- 12. Aminoglycosides and aminocyclitols -- 13. β-Lactam antibiotics : cephalosporins -- 14. β-Lactam antibiotics: penicillins -- 15. Other β-lactam antibiotics -- 16. Chloramphenicol and thiamphenicol -- 17. Diaminopyrimidines -- 18. Fosfomycin and fosmidomycin -- 19. Fusidanes -- 20. Glycopeptides -- 21. Lincosamides -- 22. Macrolides -- 23. Mupirocin -- 24. Nitroimidazoles -- 25. Oxazolidinones -- 26. Quinolones -- 27. Rifamycins -- 28. Streptogramins -- 29. Sulfonamides -- 30. Tetracyclines -- 31. Miscellaneous antibacterial agents -- 32. Antifungal agents -- 33. Antimycobacterial agents -- 34. Anthelmintics -- 35. Antiprotozoal agents -- 36. Antiretroviral agents -- 37. Other antiviral agents -- 38. Sepsis -- 39. Abdominal and other surgical infections -- 40. Infections associated with neutropenia and transplantation -- 41. Infections in intensive care patients -- 42. Infections associated with implanted medical devices -- 43. Antiretroviral therapy for HIV -- 44. Infections of the upper respiratory tract -- 45. Infections of the lower respiratory tract -- 46. Endocarditis -- 47. Infections of the gastrointestinal tract -- 48. Hepatitis -- 49. Skin and soft-tissue infections -- 50. Bacterial infections of the central nervous system -- 51. Viral infections of the central nervous system -- 52. Bone and joint infections -- 53. Infections of the eye -- 54. Urinary tract infections -- 55. Infections in pregnancy -- 56. Sexually transmitted diseases -- 57. Leprosy -- 58. Tuberculosis and other mycobacterial infections -- 59. Superficial and mucocutaneous mycoses -- 60. Systemic fungal infections -- 61. Zoonoses -- 62. Malaria -- 63. Other protozoal infections -- 64. Helminthic infections.
  • The concept of delivering 'magic bullets' to treat diseases was first proposed by Paul Erlich in the early 1900's. The realization of this concept for the treatment of cancer occurred in the late 1990's with the approval of monoclonal antibody therapies. The use of monoclonal antibodies conjugated (linked) to potent cytotoxic agents (antibody-drug conjugates, ADCs) for specifically delivering cytotoxics to cancer cells was an obvious extension of antibody-based therapy. ADCs have been under intense investigation for several decades; progress, however, has been limited due to toxicity or lack of improved efficacy compared to unconjugated cytotoxics. More recently, linker technology and target selection have advanced such that several ADCs and immunotoxins are undergoing clinical testing or are approved for use. This important volume gives the latest and most comprehensive information on the topic, describing different types of ADCs and immunotoxins for both hematologic and solid malignancies. Finally, the volume highlights the promise that this technology holds for diverse types of human cancer.
  • Antifungal agents 2005, Springer Protocols
    Susceptibility testing methods of antifungal agents / Erika J. Ernst -- Deoxyribonucleic acid fingerprinting methods for Candida species / Shawn R. Lockhart ... [et al.] -- CARE-2 fingerprinting of Candida albicans isolates / Joachim Morschhäuser, Peter Staib, and Gerwald Köhler -- Targeted gene deletion in Candida albicans wild-type strains by MPAR flipping / Joachim Morschhäuser, Peter Staib, and Gerwald Köhler -- Application of Deoxyribonucleic acid microarray analysis to the study of azole antifungal resistance in Candida albicans / Katherine S. Barker and P. David Rogers -- Application of proteomic analysis to the study of azole antifungal resistance in Candida albicans / Massoumeh Z. Hooshdaran, George M. Hilliard, and P. David Rogers -- Techniques for antifungal susceptibility testing of Candida albicans biofilms / Gordon Ramage and Josʹe Luis Lʹopez-Ribot -- Natural products and antifungal drug discovery / Melissa R. Jacob and Larry A. Walker -- Use of an animal model of disseminated candidiasis in the evaluation of antifungal therapy / David Andes -- Murine model of invasive aspergillosis / Russell E. Lewis and Nathan P. Wiederhold -- Antifungal combinations / Roxana G. Vitale, Javier Afeltra, and Eric Dannaoui -- Post-antifungal effect methods / Roxana G. Vitale -- Evaluation of immunotherapy in invasive candidiasis: antifungal activity and cytokine expression assays / Maria Simitsopoulou and Emmanuel Roilides -- Interaction of histoplasma capsulatum with human macrophages, dendritic cells, and neutrophils / Simon L. Newman -- Immunology of infection caused by cryptococcus neoformans / Floyd L. Wormley, Jr. and John R. Perfect.
  • Pt. 1. General properties of antimicrobial agents -- Pt. 2. Resistance to antimicrobial agents -- Pt. 3. General principles of usage of antimicrobial agents -- Pt. 4. Therapeutic use of antimicrobial agents.
  • Antiplatelet agents 2012, Springer
    Part 1.Pathophysiology.Platelets: Production, Morphology and Ultrastructure /Jonathan N. Thon and Joseph E. Italiano --Platelet Receptors /Alexandre Kauskot and Marc F. Hoylaerts --Platelet Signaling /Timothy J. Stalker, Debra K. Newman, Peisong Ma, Kenneth M. Wannemacher and Lawrence F. Brass --Platelet Interaction with the Vessel Wall /Philip G. de Groot, Rolf T. Urbanus and Mark Roest --Platelets in Atherosclerosis and Thrombosis /Christian Schulz and Steffen Massberg --Part 2.Pharmacology.Aspirin and Other COX-1 Inhibitors /Carlo Patrono and Bianca Rocca --Thienopyridines and Other ADP-Receptor Antagonists /Isabell Bernlochner and Dirk Sibbing --Glycoprotein IIb/IIIa Antagonists /Karen M. Hook and Joel S. Bennett --Targeting Phosphodiesterases in Anti-platelet Therapy /Matthew T. Rondina and Andrew S. Weyrich --PAR-1 Inhibitors: A Novel Class of Antiplatelet Agents for the Treatment of Patients with Atherothrombosis /Sergio Leonardi and Richard C. Becker --Thromboxane Receptors Antagonists and/or Synthase Inhibitors /Giovanni Davì, Francesca Santilli and Natale Vazzana --Inhibitors of the Interaction Between von Willebrand Factor and Platelet GPIb/IX/V /Paolo Gresele and Stefania Momi --Inhibitors of the Interactions Between Collagen and Its Receptors on Platelets /Hans Deckmyn, Simon F. De Meyer, Katleen Broos and Karen Vanhoorelbeke --Intracellular Signaling as a Potential Target for Antiplatelet Therapy /Patrick Andre --Novel Targets for Platelet Inhibition /Kathleen Freson and Chris Van Geet --Variability of Platelet Indices and Function: Acquired and Genetic Factors /Giovanni de Gaetano, Iolanda Santimone, Francesco Gianfagna, Licia Iacoviello and Chiara Cerletti --Small RNAs as Potential Platelet Therapeutics /Leonard C. Edelstein and Paul F. Bray --Pharmacological Modulation of the Inflammatory Actions of Platelets /Richard Amison, Clive Page and Simon Pitchford --Part 3.Therapy.The Role of Laboratory Monitoring in Antiplatelet Therapy /Marco Cattaneo --Antiplatelet Agents in Ischemic Heart Disease /Christopher H. May and A. Michael Lincoff --Antiplatelet Therapy in Cerebrovascular Disorders /Ralph Weber, Johannes Brenck and Hans-Christoph Diener --Antiplatelet Therapy in Peripheral Artery Disease /Francesco Violi, Stefania Basili, Jeffrey S. Berger and William R. Hiatt --Primary Prevention of Ischaemic Cardiovascular Disorders with Antiplatelet Agents /Tom Mead.
  • Antiplatelet Agents: Current and Novel -- Antiplatelet Drug Resistance and Variability in Response: The Role of Antiplatelet Therapy Monitoring -- Anticoagulant Drugs: Current and Novel -- Antithrombotic Treatment of Cardiovascular Disease -- Approaches to the Prophylaxis and Treatment of Venous and Cardiac Thromboembolic Disease.
  • Antisense therapeutics. 2nd ed. 2005, Springer Protocols
    Antisense therapeutics: a promise waiting to be fulfilled / M. Ian Phillips -- Antisense inhibition: oligonucleotides, ribozymes and siRNAs / Y. Clare Zhang ... [et al.] -- Local application of antisense for prevention of restenosis / Patrick L. Iversen ... [et al.] -- Antisense therapeutics for hypertension: targeting the renin-angiotensin system / M. Ian Phillips and Birgitta Kimura -- Antisense strategies for the treatment of heart failure / Sian E. Harding, Federica del Monte, and Roger J. Hajjar -- Clinical studies of antisense oligonucleotides for cancer therapy / Rosanne M. Orr and F. Andrew Dorr -- Antisense therapy in clinical oncology: preclinical and clinical experiences / Ingo Tamm -- Radionucleide-peptide nucleic acid diagnosis and treatment of pancreatic cancer / Eric Wickstrom ... [et al.] -- Suppression of pancreatic and colon cancer cells by antisense K-ras RNA expression vectors / Kazunori Aoki, Shumpei Ohnami, and Teruhiko Yoshida -- Induction of tumor cell apoptosis and chemosensitization by antisense strategies / Manuel Rieber and Mary Strasberg-Rieber -- Utility of an anti-oncogene ribozymes and antisense oligonucletoides in reversing drug resistance / Tadao Funato -- Transport of antisense across the blood-brain barrier / Laura B. Jaeger and William A. Banks -- Transdermal delivery of antisense oligonucletoides / Rhonda M. Brand and Patrick L. Iversen -- Antisense strategies for redirection of drug metabolism: using paclitaxel as a model / Vikram Arora -- Antisense oligonucletoide treatment of inflammatory bowel diseases / Bruce R. Yacyshyn -- Optimizing electroporation conditions for the intracellular delivery of morpholino antisense oligonucleotides directed against the hepatitis C virus internal ribosome entry site / Ronald Jubin.
  • Aromatase inhibitors 2006, Springer
  • The paradigm for atrial fibrillation (AF) management has changed significantly in recent years. A new era has begun for the prevention of one of the most tremendous complication of AF, stroke. Prevention of ischemic stroke in AF patients with oral anticoagulants represents a huge challenge because of the narrow therapeutic change of these drugs, interindividual and intraindividual variability, and the unsatisfactory time in therapeutically range (TTR) with this type of medication.
  • Microbial drug resistance: a historical perspective / William C. Summers -- Ecology of antibiotic resistance genes / Abigail A. Salyers, Nadja Shoemaker, and David Schlesinger -- Global response systems that confer resistance / Paul F. Miller and Philip N. Rather -- Multidrug efflux pumps: structure, mechanism, and inhibition / Olga Lomovskaya ... [et al.] -- Mechanisms of aminoglycoside antibiotic resistance / Gerard D. Wright -- Resistance to [beta]-lactam antibiotics mediated by [beta]-lactamases : structure, mechanism, and evolution / Jooyoung Cha, Lakshmi P. Kotra, and Shahriar Mobashery -- Target modification as a mechanism of antimicrobial resistance / David C. Hooper -- Antibiotic permeability / Harry Taber -- Genetic methods for detecting bacterial resistance genes / Ad C. Fluit --Evolution and epidemiology of antibiotic-resistant pneumococci / Christopher Gerard Dowson and Krzysztof Trzcinski -- Antimicrobial resistance in the enterococcus / George M. Eliopoulos -- Methicillin resistance in staphylococcus aureus / Keeta S. Gilmore, Michael S. Gilmore, and Daniel F. Sahm -- Mechanism of drug resistance in mycobacterium tuberculosis / Alex S. Pym and Stewart T. Cole -- Antibiotic resistance in enterobacteria / Nafsika H. Georgopapadakou -- Resistance as a worldwide problem / Paul Shears -- Public health responses to antimicrobial resistance in outpatient and inpatient settings / Cindy R. Friedman and Arjun Srinivasan -- Antibacterial drug discovery in the 21st century / Steven J. Projan.
  • The emergence of bioinformatics : historical perspective, quick overview and future trends / Christos A. Ouzounis -- The statistical design and interpretation of microarray experiments / Kevin K. Dobbin and Richard M. Simon -- Whole-genome analysis of cancer / Steven A. Enkemann ... [et al.] -- Bioinformatics approaches to the analysis of the transcriptome of animal models of cancer / Mark J. Hoenerhoff ... [et al.] -- Significance of aberrant expression of miRNAs in cancer cells / George A. Calin ... [et al.] -- Proteomic methods in cancer research / Scot Weinberger and Egisto Boschetti -- Comprehensive genomic profiling for biomarker discovery for cancer detection, diagnostics and prognostics / Xiaofeng Zhou ... [et al.] -- Gene expression profiling of the leukemias : oncogenesis, drug responsiveness, and prediction of clinical outcome / Lars Bullinger, Hartmut Dohner, and Jonathon R. Pollack -- Personalized medicine in the clinical management of colorectal cancer / Anthony El-Khoueiry and Heinz Josef Lenz -- PIK3CA gene alterations in human cancers / Sérgia Velho, Carla Oliveira, and Raquel Seruca.
  • Multiple Myeloma (MM) is the second most common type of blood cancer, resulting from an overproduction of cancerous infection-fighting white blood cells, known as plasma cells. Plasma cells are a crucial part of the immune system responsible for the production of antibodies. Bortezomib is a promising anticancer drug targeting the proteasome. This proteasome inhibitor induces cell stress and apoptosis in the cancer cells. While multiple mechanisms are likely to be involved, proteasome inhibition may prevent the degradation of pro-apoptotic factors, permitting activation of programmed cell death in neoplastic cells dependent upon the suppression of proapoptotic pathways. This monograph on bortezomib is a valuable source of information for researchers and clinicians from the fields of oncology and pharmacology, working either in academia or the pharmaceutical industry.
  • Mechanism of action of topoisomerase I poisons / Leroy F. Liu and Shyamal D. Desai -- Crystallographic insight into the mechanism of drug-induced topoisomerase I DNA damage / Alex B. Burgin, Jr., Bart L. Staker, and Lance Stewart -- Inhibitors of topoisomerase I function / Sidney M. Hecht -- Cytotoxic mechanisms of the topoisomerase I inhibitors / Yves Pommier ... [et al.] -- Biochemical and genetic analyses of DNA topoisomerase I-mediated DNA damage / Robert C.A.M. Van Waardenburg and Mary-Ann Bjornsti -- Preclinical models for evaluating topoisomerase-I targeted drugs / Aarti S. Juvekar ... [et al.] -- Mechanisms of resistance to camptothecins / Zeshaan A. Rasheed and Eric H. Rubin -- Recent advances in camptothecin drug design and delivery strategies / Thomas G. Burke ... [et al.] -- Clinical experience with 9-aminocamptothecin: lessons for new drug development / Chris H. Takimoto -- Clinical studies of rubitecan (9-nitro 20(s) camptothecin) / Hilary Hewes, Judith A. Smith, and Claire Verschraegen -- Irinotecan: current clinical status and pharmacological aspects / Laurent P. Rivory -- Clinical experience with topotecan / Aimee K. Bence and Val R. Adams -- The clinical development of lurtotecan: experience with water-soluble and liposomal forms / Keith T. Flaherty ... [et al.] -- Preclinical and clinical development of dx-8951f (exatecan mesylate): a hexacyclic camptothecin analog / Eric K. Rowinsky -- Camptothecins in the treatment of primary brain tumors / Clinton F. Stewart, Markos Leggas, and Henry S. Friedman -- Camptothecins in the treatment of lung cancer / Pankaj Kumar ... [et al.] -- Use of camptothecins in the treatment of leukemia and related disorders / Bejamin M.F. Mow and Scott H. Kaufmann.
  • Clinical strategies for cancer treatment: the role of drugs -- Target identification and drug discovery -- Clinical drug development and marketing approval -- Principles of pharmacokinetics -- Delivering anticancer drugs to brain tumors -- Pharmacogenetics -- Physical barriers to drug delivery -- Antifolates -- 5-fluoropyrimidines -- Cytidine analogues -- Purine antimetabolites -- Hydroxyurea -- Antimitotic drugs -- Alkylating agents -- Platinum analogues -- Bleomycin and other antitumor antibiotics -- Topoisomerase I-targeting drugs -- Topoisomerase II inhibitors: anthracyclines -- Topoisomerase II inhibitors: the epipodophyllotoxins -- Asparaginase -- Proteasome inhibitors -- Histone deacetylase inhibitors in oncology -- Differentiating agents -- Arsenic trioxide -- Antibodies -- Inhibitors of tumor angiogenesis -- Epidermal growth factor receptor inhibitors -- HER2 inhibitors -- Molecular targeted drugs -- Signaling inhibitors: IGFR, PI3K pathway, embryonic signaling inhibitors, and mitotic kinase inhibitors -- Cytokine therapy for cancer -- Cancer vaccines -- Adoptive cellular therapies -- Thalidomide and its analogs in the treatment of hematologic malignancies, including multiple myeloma, and solid tumors -- Hormonal therapy of breast cancer -- Hormone therapy for prostate cancer -- Drug therapy of pain in cancer patients -- Hematopoietic growth factors -- Antinausea medications -- Bisphosphonates and other bone-targeted therapies -- Intravenous access and catheter management -- Late effects of cancer chemotherapy -- Infertility after cancer chemotherapy.
  • A simple introduction explaining the broad principles underlying chemotherapy, this book gives trainees a framework within which they can place the specific aspects of cancer chemotherapy they encounter in their everyday experience. The first part of this book is unique in explaining the recent developments in the field in terms of their point of action in the natural history of cancer. The second and third sections contain a more straightforward description of practical aspects of chemotherapy, and the current place of drug treatment in everyday cancer management, including the outcomes of that treatment.
  • Cancer drug resistance 2006, Springer
  • 1. GRB2 Signaling as a Molecular Target for Cancer / Alessio Giubellino -- 2. Human Arylamine N-acetyltransferase 1: From Drug Metabolism to Drug Target / Fernando Rodrigues-Lima, Julien Dairou, Florent Busi, and Jean-Marie Dupret -- 3. Targeting Argininosuccinate Synthetase in Cancer Therapy / Niramol Savaraj, Min You, Chunjing Wu, Macus Tien Kuo, Vy Dinh, Medhi Wangpaichitr, and Lynn Feun -- 4. Parathyroid Hormone-Related Peptide Signaling in Cancer / Franco Oreste Ranelletti and Giovanni Monego -- 5. Signalling Molecules as Selective Targets for Therapeutic Strategies in Multiple Myeloma / Francesco Piazza and Gianpietro Semenzato -- 6. Role of Bile Acids in Carcinogenesis of Gastrointestinal Tract / Hiroshi Yasuda and Fumio Itoh -- 7. AIB1: A Transcriptional Coactivator Which Integrates Signaling Cross Talk in Cancer Cells / Macarena Ferrero and Jaime Font de Mora -- 8. Rational Design of DNA Anticancer Agent That Targets Signal Transducer and Activator of Transcription 3 (Stat3) for Cancer Therapy / Naijie Jing -- 9. Estrogen Receptor Signaling in Lung Cancer / P.A. Hershberger and J.M. Siegfried -- 10. Microparticle Dissemination of Biological Activities: Implications for Cancer Biology / Pauline P. Goh -- 11. Protein Kinase D Signaling in Cancer / Peter Storz -- 12. Cell Signaling and Cancer: Integrated, Fundamental Approach Involving Electron Transfer, Reactive Oxygen Species, and Antioxidants / Peter Kovacic and Ratnasamy Somanathan -- 13. Targeting Signal Transducer and Activator of Transcription (STAT) for Anticancer Therapy / Fabio P.S. Santos, Inbal Hazan-Halevy, and Zeev Estrov.
  • Use of psychotropic drugs has come to dominate clinical practice in psychiatry worldwide--perhaps owing largely to perceived simplicity, ease of use, and apparent efficiency, as well as apparent cost-effectiveness of such treatments. Nevertheless, medicinal treatments for patients with psychiatric disorders are but one component of comprehensive clinical care of complex human problems. Extensively updated since its second edition in 1985, Chemotherapy in Psychiatry, Third Edition, again addresses basic aspects of modern psychopharmacology and clinical applications of drugs used in the treatment of major psychiatric disorders, with major emphasis on psychotic, bipolar, and depressive disorders. The presentation covers descriptions of the main classes of psychotropic drugs, selected information concerning their known action mechanisms and metabolic disposition, and their clinical applications for acute illnesses and to prevent recurrences and long-term morbidity. Also covered are limitations and adverse effects of each type of agent, with emphasis on the fact that all psychotropic medicines have adverse effects that range from annoying to potentially lethal. Chemotherapy in Psychiatry, Third Edition, outlines the need to balance benefits and risks at the level of individual persons. Authoritative, and an important contribution to the literature, Chemotherapy in Psychiatry, Third Edition is an invaluable resource for physicians, scientists, trainees, and policymakers.
  • Scientific basis of cancer chemotherapy -- Norton-simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Continuous intravenous infusion chemotherapy -- Intraarterial chemotherapy -- Isolated regional therapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of chemotherapy -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of antineoplastic therapy -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Renal and electrolyte abnormalities due to chemotherapy -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- General issues in brain tumor chemotherapy -- Chemotherapy of head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestinal cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancers -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy of hodgkin's lymphoma -- Non-hodgkin's lymphoma -- Acute myeloid leukemia, acute lymphoblastic leukemia, and chronic lymphocytic leukemia -- Chemotherapy of the myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma and other plasma cell disorders.
  • "Written for Pain Management Practitioners, Oncologists, Oncology Nurses, Nurse Practitioners, Social Workers, Pharmacologists, and Primary Care Practitioners, as well as students in these fields, this reference provides insight into chemotherapy-induced neuropathic pain cancer survivors suffer. It reviews the basic and clinical research into the normal physiology of pain transmission pathways, neuropathic pain pathology, the chemotherapeutic drug mechanisms of action and adverse effects, chemotherapy-induced neuropathy, and drug discovery efforts for treatment. Bridging the gap between theory and practice, this reference covers both basic science and clinical research, providing a unique insight into drug discovery efforts"--Provided by publisher.
  • Carbamazepine -- Felbamate -- Gabapentin -- Lamotrigine -- Levetiracetam -- Oxcarbazepine -- Phenobarbital, primidone -- Phenytoin -- Pregabalin -- Tiagabine -- Topiramate -- Valproic -- Zonisamide.
  • Colorectal cancer 2007, Springer
    Molecular biology of colon cancer / William M. Grady -- Chemoprevention of colorectal cancer / Yu-Ning Wong ...[et al.] -- Colorectal cancer screening and surveillance / Arnold J. Markowitz -- Cytotoxic chemotherapy for metastatic colorectal cancer / M. Wasif Saif, Richard Kim, and Edward Chu -- Integration of antiangiogenic strategies in colorectal cancer treatment / John M. Strother and Charles D. Blanke -- The role of EGFR inhibition in colorectal cancer / Nabeel Shalan and Paulo M. Hoff -- Second-line strategies in the treatment of patients with metastatic colorectal cancer / Anthony B. El-Khoueiry and Heinz-Josef Lenz -- Adjuvant chemotherapy for colon cancer / Bert H. O'Neil ... [et al.] -- Management of locally advanced rectal cancer / Yu Jo Chua and David Cunningham -- Rationale for adjuvant and neoadjuvant chemotherapy in the resection of liver metastases / Axel Grothey and Steven A. Alberts -- Percutaneous radiofrequency ablation in the management of patients with colorectal cancer / Karen Brown -- Colorectal cancer imaging / Sean D. Curran and Laurence H. Schwartz -- Nursing issues in colorectal cancer chemotherapy / Ellen Hollywood and Deborah Semple -- Pain management in the colorectal cancer patient / Vivek Tim Malhotra -- Novel agents and new paradigms for colorectal cancer / Chris Takimoto and Russell Kruzelock.
  • Targeting of the EGFR as a modulator of cancer chemotherapy / Jose Baselga -- Cyclin dependent kinase inhibitors in combination chemotherapy / Manish A. Shah and Gary K. Schwartz -- Development of protein kinase C and cyclin-dependent kinase inhibitors as potentiators of cytotoxic drug action in leukemia / Steven Grant -- Carboxyamidotriazole, an inhibitor of nonvoltage operated calcium entry : single agent and combination therapy for ovarian carcinoma / Chad M. Michener and Elise C. Kohn -- Targeted alpha particle therapy : a rational approach to drug development in hematologic diseases and solid tumors / John M. Burke, David A. Scheinberg, and Joseph G. Jurcic -- Pharmacologic modulation of fluoropyrimidines : building upon the lessons of the past / Owen A. O'Connor -- Development of inhibitors of HER2 with taxanes : new directions in breast cancer therapy / Shanu Modi, Monica N. Fornier, and Andrew D. Seidman -- Targeting nf-b to increase the activity of cisplatin in solid tumors / Don S. Dizon ... [et al.] -- Combinations of chemotherapy and G3139, an antisense BCL-2 oligonucleotide / Luba Benimetskaya, Sridhar Nami, and C. A. Stein -- Use of animal models to evaluate signal transduction inhibitors as modulators of cytotoxic therapy / Beverly A. Teicher.
  • Complement therapeutics 2013, Springer
  • v. 1. Global perspective / volume editor, Peter D. Kennewell -- v. 2. Strategy and drug research / volume editor, Walter H. Moos -- v. 3. Drug discovery technologies / volume editor, Hugo Kubinyi -- v. 4. Computer-assisted drug design / volume editor, Jonathan S. Mason -- v. 5. ADME-Tox approaches / volume editors, Bernard Testa and Han van de Waterbeemd -- v. 6. Therapeutics areas I: central nervous system, pain, metabolic syndrome, urology, gastrointestinal and cardiovascular / volume editor, Michael Williams -- v. 7. Therapeutic areas II: cancer, infectious diseases, inflammation & immunology and dermatology / volume editors, Jacob J. Plattner & Manoj C. Desai -- v. 8. Case histories and cumulative subject index / volume editors, John B. Taylor & David J. Triggle.
  • The pace of new research and level of innovation repeatedly introduced into the field of drug delivery to the lung is surprising given its state of maturity since the introduction of the pressurized metered dose inhaler over a half a century ago. It is clear that our understanding of pulmonary drug delivery has now evolved to the point that inhalation aerosols can be controlled both spatially and temporally to optimize their biological effects. These abilities include controlling lung deposition, by adopting formulation strategies or device technologies, and controlling drug uptake and release.
  • Classification of the Antibiotics -- Antibiotics Marketed in the EU -- Principles of Antibiotic Therapy -- The Most Common Errors in Antibiotic Therapy -- Important Infections and Their Microbiological Diagnosis -- Cooperation with Microbiologists -- Resistance of Major Clinical Pathogens -- The Most Frequent Pathogens- Choice of Antibiotics -- Antibiotics, Antimycotics: Spectrum- Dosage- Adverse Effects- Costs -- Antibiotic Therapy of the Principal Infections in Children and Adults -- Treatment of the Most Frequent Types of Bacterial Endocarditis -- Minimal Duration of Treatment for Bacterial Infections -- Failure of Antibiotic Therapy -- Fever of Unknown Origin: Differential Diagnosis -- Dosage of Antibiotics in Impaired Renal Function -- Antibiotic Therapy in Haemodialysis, Peritoneal Dialysis, and Continuous Haemofiltration -- Antibiotic Therapy During Pregnancy and Lactation -- Antibiotics in Liver Diseases -- Diffusion of Antibiotics in Cerebrospinal Fluid and in Cerebral Abscesses -- Local Antibiotics -- Prophylactic Antibiotic Therapy -- Physical Incompatibility of Antibiotics and Antimycotics in Infusion Solutions -- Useful Websites.
  • "Novel drug delivery technologies strive to bypass challenging biological layers to elicit desired pharmacological activity. The skin, one of our key defensive barriers, is imperfect, and may allow certain topically applied substances or toxins to pass. The dermatokinetics of a drug determines the efficacy of treatment of skin disorders. Presenting the first comprehensive reference on this important area of research, Dermatokinetics of Therapeutic Agents includes a general overview of the theoretical as well as practical aspects of dermatokinetics and addresses the impact of nature of a drug delivery system on the dermatokinetics of drugs. Chapters and illustrations cover the introductory aspects significance, methods, and models used in dermatokinetic studies of therapeutic agents.Topics include: Theoretical Models for Dermatokinetics of Therapeutic Agents; Drug Delivery Approaches to Modulate Dermatokinetics of Drugs; Conventional Methods of Cutaneous Drug Sampling; Cutaneous Microdialysis; Sampling Substrates by Skin Permeabilization; Spectroscopic Techniques in Dermatokinetics Studies; Regulatory Perspective of Dermatokinetic Studies"--Provided by publisher.
  • "Reduced production of DHEA associated with the diseases that accompany aging has led to its use as a nutritional supplement for antiaging, metabolic support, and other purposes. While animal studies have clearly shown substantial benefits of DHEA in combating various disease states, the effect of low levels of DHEA in humans is less established, and the mechanisms of action and potential involvement in illnesses remain unclear. DHEA in Human Health and Aging reviews the past ten years of research into this hormone and explores its potential for future study."--Publisher's description.
  • Fulltext ClinicalKey
    Introduction and overview of current targets: bench to clinic / Mark R. Kelley -- 2. MGMT a critical DNA repair gene target for chemotherapy resistance / Stanton L. Gerson and Lili Liu -- 3. Blockade of base excision repair: inhibition of small lesions results in big consequences to cancer cells / Melissa Fishel and Carlo Vascotto -- 4. PARP inhibitors -- scientific rationale and clinical development for cancer / Ruth Plummer, Nicola J. Curtin and Yvette Drew -- 5. Inhibiting selective DNA polymerases for therapeutic intervention / Anthony J. Berdis -- 6. Targeting the nucleotide excision repair pathway for therapeutic applications / John Turchi and Stephan M. Patrick -- 7. Homologous recombination and ATM/ATR targets / Henning Willers, Lee Zou and Heike N. Pfaffle -- 8. DNA double strand break repair by nonhomologous end joining and its clinical relevance / Michael Weinfeld and Susan Lees-Miller -- 9. Defective MMR-c-Abl-p73-GADD45alpha expression in cancer chemoresistance / David Boothman and Long Shan Li -- 10. DNA repair signaling targets / Susan Ashwell -- 11. Redox regulation of DNA repair and therapeutic / Millie M. Georgiadis -- 12. Personalized cancer medicine: DNA repair alterations is a promising predictive marker in cancer / Srinivasan Madhusudan -- 13. The role of DNA damage and repair in neurotoxicity caused by cancer therapies / Michael R. Vasko -- 14. Future directions with DNA repair inhibitors / Mark R. Kelley.
  • "Drug delivery technologies represent a vast and vital area of research and development in pharmaceutics. The demand for innovative drug delivery systems continues to grow, and this growth drives a variety of new developments. Building on the foundation provided by the second edition, Drug Delivery Systems, Third Edition covers the latest in research, development, and regulations in industry and academia.The third edition of this popular book provides a comprehensive review of the latest research and development on drug delivery systems (including liposomal, transmucosal, transdermal, oral, polymeric, and monoclonal antibody directed delivery); it also contains a new chapter on nanoscience and technology for drug delivery along with cutting-edge business intelligence and strategies. These topics are spread into five sections: Site-specific drug delivery Polymers and implantable drug delivery systems Oral drug delivery Transdermal, transmucosal, ocular, and miscellaneous drug delivery systems Regulatory considerations and global outlook Written in a straightforward, clear, and concise manner, the authors provide a global perspective on current and future advances and market opportunities. The book answers the need for comprehensive information in a single resource for anyone venturing into this area of drug development and who desires an overview of the field, with extensive guidance on where to gain more information. Each chapter provides a table of marketed and investigational products, with numerous practical examples; the book also provides readers with a multitude of possible drug delivery systems that can be used to improve therapeutics, along with global and regulatory perspectives"--Provided by publisher.
  • Introduction to Drug-Drug Interactions -- Mechanisms of Drug Interactions I: Absorption, Metabolism, and Excretion -- Mechanisms of Drug Interactions II: Transport Proteins -- Drug-Food Interactions -- Interactions Between Herbs and Antiinfective Medications -- Drug-Cytokine Interactions -- Beta-Lactam Antibiotics -- Macrolides, Azalides, and Ketolides -- Quinolones -- Glycopeptides, Lipopeptides, and Lipoglycopeptides -- Miscellaneous Antibiotics -- Drugs for Tuberculosis -- Drug Interactions with Antiretrovirals for HIV Infection -- Non-HIV Antiviral Agents -- Antifungal Agents -- Antimalarial Agents -- Antiprotozoal and Anthelmintic Agents -- Drug Interaction Considerations Throughout Drug Development -- Probe Cocktail Studies -- Design and Data Analysis in Drug Interaction Studies.
  • With people aged 65 years and older currently making up the fastest growing age group throughout the world, the demographic revolution of an aging society will inevitably lead to increased pressure to develop a rationalistic and age-tailored process of diagnosis and treatment among the elderly. As aging people often suffer from several chronic diseases and are being treated with multiple medications concurrently, unwanted drug interactions occur more frequently. Whereas recent approaches have recommended to remove particular drugs from the medication regimen to avoid adverse effects, Drug Therapy for the Elderly underlines both indispensable and dispensable elements of drug treatment, providing the practitioner with:- Background information on the elderly population regarding their needs for particular drugs (with an eye to frailty, co-morbidity patterns, and special sensitivities regarding drug metabolism and excretion)- Practical advice about drug treatment surveillance parameters in the elderly- In-depth discussion of drugs in relation to the elderly with specific diagnoses- Integration of multimorbidity/polypharmacy situations into prioritization schemes- A plan for how to deal with the complexity of polypharmacy situations in a five-minute consultationAn original classification of drugs is proposed by the editor which relates the power of effects, prognostic data, and tolerability to a prioritization scoring system. This approach is the first to not only provide a negative listing, but also integrates positive data into an overall assessment for drugs fit for the aged. Therefore, Drug Therapy for the Elderly serves as a timely reference for a wide array of physicians.
  • This Adis Pocket Reference presents an up-to-date, succinct, and practical approach to drug therapy for type 2 diabetes.
  • Drug-eluting stents 2012, Future Med
    Drug-eluting stents / Imad Sheiban & Fabrizio D'Ascenzo -- Drug-eluting stents : overview and indications / Fabrizio D'Ascenzo & Imad Sheiban -- Coronary artery stents : approved first-generation drug-eluting stents / Jason R. Foerst, Frank Gruenheck, Malte Kelm & Marc Vorpahl -- Approved drug-eluting stents : second generation / Giampaolo Niccoli & Gregory A. Sgueglia -- Drug-eluting stents in development / Joanne Shannon & Azeem Latib -- Current guidelines for the use of drug-eluting stents / Gill Louise Buchanan & Alaide Chieffo -- Index.
  • Drugs affecting 5-HT systems 2013, Wellcome Trust
  • General commentary on drug therapy and drug risks in pregnancy / Richard K. Miller, Paul W. Peters, and Christoff E. Schaefer -- Specific drug therapies during pregnancy / Mimke Reuvers and Christof Schaefer -- General commentary on drug therapy and drug risk during lactation / Ruth Lawrence and Christof Schaefer -- Specific drug therapies during lactation / Chistof Schaefer and Ruth Lawrence.
  • "Growth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor (EGFR, ErbB, HER) system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab (Herceptin) for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1/-2 inhibitors such as lapatinib (Tykerb/Tyverb). Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting."
  • Drugs in ophthalmology 2006, Springer
  • Easy injections 2007, ClinicalKey
    Introduction to injections -- Medications and injection supplies -- Joints -- Tendons -- Bursae -- Nerves -- Trigger point injections -- Botulinum toxin -- Prolotherapy -- Acupuncture -- Sympathetic injections -- Spinal injections.
  • Genomic experimental approaches in oncology -- Pharmacogenomics of toxicity and response of chemotherapy -- Pharmacogenomics in clinical drug development in oncology.
  • Introduction /Terrence P. Tougas, Jolyon P. Mitchell --Current Approaches to APSD Measurements of OIPs Based on Inertial Impaction /Jolyon P. Mitchell, Daryl L. Roberts --Physical Causes of APSD Changes in Aerosols from OIPs and Their Impact on CI Measurements /Helen Strickland, Beth Morgan --Good Cascade Impactor Practices /Jolyon P. Mitchell --The AIM and EDA Concepts: Why They Are Needed and How They Fit Together /Jolyon P. Mitchell, Terrence P. Tougas --Product Life Cycle Approach to Cascade Impaction Measurements /Richard Bauer, J. David Christopher --Theoretical Basis for the EDA Concept /Terrence P. Tougas, Jolyon P. Mitchell --Performance Characterization of EDA and Its Potential to Improve Decision Making in Product Batch Release /J. David Christopher, Helen Strickland --Verification of the EDA Concept Through an Assessment of Theoretical Failure Modes, Failure Mode Analysis, and Case Studies with Real Data /Helen Strickland, Beth Morgan --Validating AIM-Based Instrumentation and Associated Measurement Techniques /Mark Copley, Jolyon P. Mitchell --The Regulatory and Compendial Pathways to Acceptance for AIM and EDA Concepts /Steven C. Nichols, Jolyon P. Mitchell --Applying the AIM Concept in Support of Developing Improved In Vitro-In Vivo Relationships for OIPs /Jolyon P. Mitchell, Mark Copley --Future Directions for the AIM and EDA Concepts /Terrence P. Tougas, Jolyon P. Mitchell --Conclusions /Terrence P. Tougas, Svetlana A. Lyapustina.
  • Print Material
  • Biologic and pharmacologic basis of cancer chemotherapy and biotherapy / Roland T. Skeel and Samir N. Khleif -- Systemic assessment of the patient with cancer and long-term consequences of treatment / Roland T. Skeel -- Selection of treatment for the patient with cancer / Roland T. Skeel -- Antineoplastic drugs and biologic response modifiers : classification, use, and toxicity of clinically useful agents / Roland T. Skeel -- High-dose chemotherapy and hematopoietic stem cell transplantation in hematologic malignancies / Roberto Rodriguez and Chatchada Karanes -- Carcinomas of the head and neck / Harlan A. Pinto -- Carcinoma of the lung / Sophie Sun and Joan H. Schiller -- Carcinomas of the gastrointestinal tract / Al B. Benson, III -- Carcinomas of the pancreas, liver, gallbladder, and bile ducts / Rekha T. Chaudhary -- Carcinoma of the breast / Iman Mohamed -- Gynecologic cancer / Stephen Andrews -- Urologic and male genital cancers / Joseph S. Chan, Scott B. Saxman, and Craig R. Nichols -- Kidney cancer / Walter D. Y. Quan, Jr. and Mikhail Vinogradov -- Thyroid and adrenal carcinomas / Haitham S. Abu-Lebdeh and Samir N. Khleif -- Melanomas and other skin malignancies / Karen S. Milligan and Walter D. Y. Quan, Jr. -- Primary and metastatic brain tumors / April F. Eichler and Tracy T. Batchelor -- Soft tissue sarcomas / Robert S. Benjamin --Bone sarcomas / Robert S. Benjamin -- Acute leukemias / Olga Frankfurt and Martin S. Tallman -- Chronic leukemias / Peter White and Paul R. Walker -- Myeloproliferative diseases and myelodysplastic syndromes / Peter White and Paul R. Walker -- Hodgkin's lymphoma / Richard S. Stein and David S. Morgan -- Non-Hodgkin's lymphoma / Richard S. Stein and John P. Greer -- Multiple myeloma, other plasma cell disorders , and primary amyloidosis / Rachid Baz and Mohamad A. Hussein -- Metastatic cancer of unknown origin / James M. Leonardo -- Human immunodeficiency virus / Mary E. Cianfrocca -- Side effects of cancer chemotherapy / Janelle M. Tipton -- Infections : etiology, treatment, and prevention / Joan M. Duggan -- Transfusion therapy, bleeding, and clotting / Mary R. Smith and NurJehan Quraishy -- Oncology emergencies and critical care issues, anaphylaxis, spinal cord compression, cerebral edema, superior vena cava syndrome, hypercalcemia, tumor lysis syndrome, and respiratory failure / Roland T. Skeel -- Malignant pleural, peritoneal, and pericardial effusions and meningeal infiltrates / Rekha T. Chaudhary -- Cancer pain / Michael J. Fisch and Charles S. Cleeland -- Emotional and psychiatric problems in patients with cancer / Kathleen S. N. Franco-Bronson and Kristi S. Williams.
  • Acute resuscitation -- Anesthesia -- Cardiovascular therapies -- Pulmonary therapies -- Renal, electrolyte, and acid base disturbances -- Endocrine therapies -- Gastroenterology, liver, and nutrition therapies -- Hematologic therapies -- Neurologic and psychiatric therapeutics -- Infectious diseases -- Allergy -- Poisonings -- Drug monitoring.
  • Handbook of Treatment-resistant Schizophrenia is a concise review of treatment-resistant schizophrenias definition, measurement tools, adherence issues, substance abuse, optimal dosing, clinicianpatient relationships, and current management approaches. The book was originally commissioned with the intention of creating a comprehensive text focusing on treatment-resistant schizophrenia and its management. The book explores many aspects of the background and practice- and research-based evidence for treating this complex subset of schizophrenia, including psychopharmacological, somatic, and nonpharmacological treatment approaches. While exploring the various therapies for treatment-resistant schizophrenia, Dr Citrome also emphasizes the importance of building strong and trusting relationships between patients and their clinicians so the clinician can best manage their patients adherence and overall treatment.
  • Thrombolytics/Anticoagulants -- Vasopressors and Inotropes -- Sedatives -- Analgesics and Neuromuscular Blocking Agents -- Hypertonic Saline, Electrolytes, and Insulin -- Anti-Infectives -- Antiarrhythmics -- Antihypertensives and Prostanoids.
  • Histone deacetylases 2011, Springer
    K-acetylation and its enzymes: overview and new developments / Juliette Adjo Aka, Go-Woon Kim, Xiang-Jiao Yang.-- Biology of HDAC in cancer: the nuclear and epigenetic components / Astrid Hagelkruys, Anna Sawicka, Magdalena Rennmayer, Christian Seiser.-- Deacetylation of nonhistone proteins by HDACs and the implications in cancer / Lirong Peng, Edward Seto.-- Biology and therapeutic implications of HDACs in the heart / Timothy A. McKinsey.-- HDACs in skeletal muscle remodeling and neuromuscular disease / Bryan J. Simmons, Todd J. Cohen, Richard Bedlack, Tso-Pang Yao.-- Rationale for HDAC inhibitor therapy in autoimmunity and trasplantation / Wayne W. Hancock.-- Role of mammalian sirtuins in the regulation of metabolism, aging, and longevity / Akiko Satoh, Liana Stein, Shin Imai.-- Mictochondrial sirtuins in the regulation of mictochondrial activity and metabolic adaption / David B. Lombard, Daniel X. Tishkoff, Jianjun Bao.-- Characterization of nuclear sirtuins: molecular mechanisms and physiological relevance / Debra Toiber, Carlos Sebastian, Raul Mostoslavsky.-- Structural biology of human netal-dependent histone deacetylases / Matthieu Schapira.-- Sirtuin modulators / Sumit S. Mahajan, Vid Leko, Julian A. Simon, Antonio Bedalov.
  • "The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases. However, no vaccine development has been easy and there is an interesting story attached to each. The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries. The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine."--Publisher's website.
  • "Malpractice settlements are large for undetected hydroxychloroquine and chloroquine toxicity which, if untreated, can lead to permanent loss of central vision. Knowledge of the ocular toxicity of these drugs has increased during the past fifty years as their use has expanded. Hydroxychloroquine and Chloroquine Retinopathy is the first single-source book on the subject and is essential for the practicing ophthalmologists, rheumatologists, dermatologists, and internists who prescribe these drugs. It covers clinical topics such as signs and symptoms of toxicity, toxicity screening, ancillary testing, to whom and why the drugs are prescribed and dosing considerations. Additionally, the book addresses practice management considerations, including coding, reimbursement and equipment costs, and the medico-legal responsibilities of the rheumatologist and of the ophthalmologist. Guidelines for the management of hydroxychloroquine and chloroquine vary around the world and differences between the guidelines of the United Kingdom, the United States, and other countries are identified. The book concludes with a collection of case examples illustrating common clinical scenarios and their management. This book is a “must-have” resource for physicians who use these drugs."--Publisher's website.
  • Microparticles as vaccine delivery systems / Derek T. O'Hagan -- MF59: a safe and potent adjuvant for human use / Audino Podda, Giuseppe Del Giudice, and Derek T. O'Hagan -- Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminium salt / Nathalie Garçon, Marcelle van Mechelen, and Martine Wettendorff -- Virosomes for vaccine delivery / Ian C. Metcalfe and Reinhard Glück -- The ISCOMATRIX adjuvant / Debbie Drane and Martin J. Pearse -- Mineral adjuvants / Erik B. Lindblad --Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin / Jan Holmgren ... [et al.] -- Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant / Richard T. Kenney and Gregory M. Glenn -- T cell adjuvants and novel strategies for their identification / Laurence Van Overvelt and Philippe Moingeon -- Vaccination to treat noninfectious diseases: surveying the opportunities / Stephen W. Martin and Martin F. Bachmann -- Clinical evaluation of adjuvants / Jakub K. Simon and Robert Edelman -- Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines / Elizabeth M. Sutkowski and Marion F. Gruber.Unravelling "the immunologist's dirty little secret" / Virgil E.J.C. Schijns -- Dendritic cells as targets and tools in vaccines / Imerio Capone, Paola Rizza, and Filippo Belardelli -- Host-derived molecules as adjuvants / Tom Barr, Jennifer Carlring, and Andrew W. Heath -- Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants / Achal Pashine, Jeffrey B. Ulmer, and Nicholas M. Valiante -- CpG oligodeoxynucleotides as vaccine adjuvants / Michael J. McCluskie and Risini D. Weeratna -- Toll-like receptor 4 agonists as vaccine adjuvants / David H. Persing ... [et al.] -- Immunomodulatory adjuvants from Quillaja saponaria / Charlotte Read Kensil --
  • Induction chemotherapy 2011, Springer
  • Injection procedures 2011, Springer
    Basic principles of joint and soft tissue injection procedures -- Pharmacotherapy of joint and soft tissue injections -- Viscosupplementation -- Low back pain: considerations of when to refer patients for interventional spine procedures -- Administrative aspects of office-based injection procedures -- The shoulder -- The elbow -- The wrist -- The hand -- The hip -- The knee and its region -- The ankle and the foot.
  • Principles of pharmacology and mechanisms of drug action -- Principles of pharmacology and mechanisms of drug action -- Drug discovery, safety and efficacy -- Neurotransmission and the peripheral autonomic nervous system -- Ischaemic heart disease -- Systemic and pulmonary hypertension -- Heart failure -- Cardiac arrhythmias -- Cerebrovascular disease and dementia -- Peripheral vascular disease -- Haemostasis -- Asthma and chronic obstructive pulmonary disease -- Respiratory disorders : cough, respiratory stimulants, cystic fibrosis and neonatal respiratory distress syndrome -- Diuretics -- Disorders of micturition -- Erectile dysfunction -- General anaesthetics -- Local anaesthetics -- Opioid analgesics and the management of pain -- Anxiolytics, sedatives and hypnotics -- The major psychotic disorders : schizophrenia and mania -- Depression, attention deficit hyperactivity disorder and narcolepsy -- Epilepsy -- Extrapyramidal movement disorders and spasticity -- Other neurological disorders : multiple sclerosis, motor neuron disease and Guillain - Barre syndrome -- Migraine and other headaches -- The neuromuscular junction and neuromuscular blockade -- Myasthenia gravis -- Non-steroidal anti-inflammatory drugs -- Rheumatoid arthritis, other inflammatory arthritides and osteoarthritis -- Hyperuricaemia and gout -- Nausea and vomiting -- Dyspepsia and peptic ulcer disease -- Inflammatory bowel disease -- Constipation, diarrhoea and irritable bowel syndrome -- Liver disease -- Obesity -- The immune response and immunosuppressant drugs -- Antihistamines and allergic disease -- Diabetes mellitus -- The thyroid and control of metabolic rate -- Calcium metabolism and metabolic bone disease -- Pituitary and hypothalamic hormones -- Corticosteroids (glucocorticoids and mineralocorticoids) -- Female reproduction -- Androgens, anti-androgens and anabolic steroids -- Anaemia and haematopoietic colony-stimulating factors -- Lipid disorders -- Skin disorders -- The eye -- Chemotherapy of infections -- Chemotherapy of malignancy -- Drug toxicity and overdose -- Substance abuse and dependence -- Prescribing, adherence and information about medicines -- Drug therapy in special situations.
  • Patients with various cancers are treated with conventional chemotherapeutic drugs and the majority responds well to such therapies. However, there is a subset of patients who does not respond initially and another subset who no longer responds to further treatments. Clearly, in those two subsets of patients, the cancer cells exhibit mechanisms of resistance. One of the main challenges facing us to date is to develop new therapies to treat patients with the resistant tumors. The development of new effective therapies will be dependent on delineating the biochemical, molecular, and genetic mechanisms that regulate tumor cell resistance. Such mechanisms have revealed gene products that directly regulate resistance and are targets for therapy. Of interest, several FDA-approved drugs were able to overcome drug resistance and have been successfully used clinically. They have been used as monotherapy or synergized with other therapies for the treatment of resistant tumors. This volume constitutes a total of twelve selective reviews by pioneer scientists in the field of cancer drug resistance. Specific mechanisms in drug resistance are reviewed and novel approaches are being proposed for therapeutic interventions. This volume is of general interest to scientists, clinicians, health care providers, and students.
  • mTORC1: a signalling integration node involved in cell growth -- The regulation of the IGF-1/mTOR pathway by the p53 tumor suppressor gene functions -- mTOR signaling in angiogenesis -- mTORC1 signaling and hypoxia -- mTOR signaling in glioblastoma: lessions learned from bench to bedside -- mTOR and cancer therapy: general principles -- mTOR and cancer therapy: clinical development and novel prospects -- Drug combinations as a therapeutic approach for mTORC1 inhibitors in human cancer -- Downstream targets of mTORC1 -- Downstream of mTOR: translational and control of cancer -- Genome-wide analysis of translational control -- Translational control of cancer: implications for targeted therapy -- Downstream from mTOR: therapeutic approaches to targeting the eIF4F translation initiation complex.
  • Part 1.Natural Product Drugs and Cancer Therapeutics --The Impact of Natural Products Upon Cancer Chemotherapy /A. Ganesan --Identification and Development of Vascular Disrupting Agents: Natural Products That Interfere with Tumor Growth /Andrea T. Hooper, Frank Loganzo, Chad May and Hans-Peter Gerber --Discodermolide: Past, Present, and Future /Ross E. Longley --HDAC Inhibitors and Other Histone Modifying Natural Products as Emerging Anticancer Agents /Lilibeth A. Salvador and Hendrik Luesch --Natural Product Cytotoxins as Payloads for Antibody Drug Conjugates /Frank E. Koehn --Part 2.Advances in Natural Product Cancer Drug Discovery --Natural Product Scaffolds in Cancer Therapy /Christian P. Mang and Lars Ole Haustedt --The Role of Genetic Engineering in Natural Product-Based Anticancer Drug Discovery /Claudia Eva-Maria Unsin, Scott R. Rajski and Ben Shen --Accessing Anti-cancer Natural Products by Plant Cell Culture /Lisa M. Leone and Susan C. Roberts --Natural Products as Tools for Discovering New Cancer Targets /John A. Beutler.
  • This updated edition of Netter's Illustrated Pharmacology allows you to take a distinct visual approach to understanding both the basic science and clinical applications of pharmacology. Designed to be compatible and used in conjunction with other pharmacology resources, this medical reference book offers a vivid, uniquely effective visual presentation of the pharmacodynamic relationship between drugs and the human body. And with the new addition of Student Consult online access, Netter's Illustrated Pharmacology is even more convenient than ever before! Available online for the first time! Search the full contents of Netter's Illustrated Pharmacology no matter what your location with convenient access to Student Consult.Visually grasp the most important principles in pharmacology with succinct, easy-to-understand presentations of introductory pharmacologic principles based on classic images by Frank Netter, as well as dynamic new illustrations from other talented medical artists.Learn how drugs are used to treat specific disorders in the body, as well as their effects on a particular site, with a format divided by organ system and full-color illustrations of the systems themselves.Access in-depth guidance on the must-know elements of each pharmacologic principle with clear, concise notes located beneath the corresponding image.
  • New drug development -- The regulatory environment -- Drug discovery -- Nonclinical research -- Designing clinical trials -- Conducting clinical trials I: Experimental methodology -- Conducting clinical trials II: Operational execution -- Statistical analysis -- Statistical significance -- Clinical significance -- Sample size estimation -- General safety assessments -- Efficacy assessment -- Cardiac and cardiovascular safety assessments -- Manufacturing small molecule drugs and biologicals -- Postmarketing surveillance -- Main themes and concluding comments -- References -- Index.
  • New oral anticoagulants 2012, Future Med
    New oral anticoagulants / Jawed Fareed -- Venous thromboembolism (post-surgery) / Erica Romualdi & Walter Ageno -- New oral anticoagulants for stroke prevention in atrial fibrillation / Sarkis Morales-Vidal, Michael J. Schneck, Murray Flaster & Jose Biller -- Acute coronary syndromes / Paul A. Gurbel & Udaya S. Tantry -- Current VTE prophylaxis and new oral anticoagulants for acute medical in-patients / Evi Kalodiki & Christopher R. Lattimer -- New antithrombotic agents in cancer patients / Grigoris T. Gerotziafas, Michel Meyer Samama & Ismail Elalamy -- New oral anticoagulants for autoimmune diseases / Debra Hoppensteadt, Jeanine M. Walenga & Mamdouh Bakhos -- New oral anticoagulants for special populations / Jeanine M. Walenga & Mamdouh Bakhos -- Will warfarin become obsolete? / Jawed Fareed, Wendy A. Leong & Joseph A. Caprini -- Index.
  • Nitric oxide and cancer: an overview -- A role for eNOS in oncogenic Ras-driven cancer -- Dual role of nitric oxide in cancer biology -- Nitric oxide expression in cancer -- S-nitrosylation: how cancer cells say NO to cell death -- Cytotoxic and protective activity of nitric oxide in cancers -- Cytotoxic/protective activity of nitric oxide in cancer -- Nitric oxide and life or death of human leukemia cells -- Inhibition of apoptosis by endogenous nitric oxide in chronic lymphocytic leukaemia -- Nitric oxide: a rate-limiting factor for metastases development -- Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB/Snail/RKIP loop -- Sensitizing effect of nitric oxide to cytotoxic stimuli -- Nitric oxide is a promising enhancer for cancer therapy -- Role of nitric oxide for modulation of cancer therapy resistance -- Breaking resistance: role of nitric oxide in the sensitization of cancer cells to chemo- and immunotherapy -- Prognostic significance of iNOS in human melanoma -- Prognostic significance of iNOS in hepatocellular carcinoma -- Prognostic significance of iNOS in esophageal cancer -- Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis -- Nitric oxide-releasing molecules for cancer therapy and chemoprevention -- Nitric oxide: monotherapy or sensitiser to conventional cancer treatments? -- Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies -- (S, R)-3-Pheynyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO): new dress for nitric oxide mission -- Nitric oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis -- Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of nitric oxide of HIF-1a: potential role of Se-Methylselenocysteine(MSC), an antioxidant multi-targeted small molecule.
  • v. 2, 2014 CRCnetBASE
    "There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed"--Provided by publisher.
  • 1.Nanoparticulate-based therapeutics: an overview /Deepak Thassu, Kris Holt, and Gerald J. Chader --2.Eye anatomy, physiology and ocular barriers: basic considerations for drug delivery /Gerald J. Chader and Deepak Thassu --3.Animal models to evaluate nanoparticulate drug delivery systems /Vinson M. Wang, Jingsheng Tuo, and Chi-Chao Chan --4.Computer modeling for ocular drug delivery /Paul J. Missel --5.Considerations for development of ophthalmic nanotechnology-based drugs /Banu S. Zolnik, Sherizaq Baksh, and Nakissa Sadrieh --6.Blood-retinal barrier: the fundamentals /Rosa Fernandes, Andreia Gonçalves, and José Cunha-Vaz --7.Barriers to transscleral drug delivery to the retina /Alexandra Almazan ... [et al.] --8.Drug delivery to the vitreous humor /Francine Behar-Cohen --9.Transscleral and suprachoroidal drug delivery /Damian E. Berezovsky and Henry Edelhauser --10.Protein drug delivery to retina and choroid /Hogwen M. Rivers and Patrick M. Hughes --11.Transscleral drug delivery to the posterior segment of the eye /Bernard F. Godley ... [et al.] --12.Drug delivery to the suprachoroidal space /Sung Won Cho and Timothy Olsen --13.Use of nanoparticles in the treatment of age-related macular degeneration, glaucoma and other degenerative retinal diseases /Marco A. Zarbin ... [et al.] --14.Drug molecule characteristics and their impact on anterior versus posterior segment drug delivery strategies /Kay D. Rittenhouse --15.Surface modulation of nanoparticles /Deepak Thassu and Kris Holt --16.Nanoparticles for the treatment of retinal diseases / Amin Famili and Uday B. Kompella --17.Gene-based medicine for ocular diseases /Shannon M. Conley and Muna I. Naash --18.Stealth-type polymeric nanoparticles with encapsulated betamethasone phosphate for treatment of intraocular inflammation /Tsutomu Sakai, Tsutomu Ishihara, and Megumu Higaki --19.Nanotechnology-guided imaging of retinal vascular disease /Joshua R. Trantum, John S. Penn, and Ashwath Jayagopal --20.Photoresponsive polymers for ocular drug delivery /Laura A. Wells and Heather Sheardown --t21.Nanosuspensions in ocular drug delivery systems /Himanshu Bhattacharjee and Sonia Bedi.
  • Antibacterial agents -- Antifungal agents -- Antiviral agents -- Anti-parasitic agents -- Anti-glaucoma agents -- Neuro-ophthalmology -- Anti-inflammatory agents -- Mydriatics, cycloplegics, and reversal agents -- Lubricants and viscoelastics -- Miscellaneous -- Anti-angiogenesis agents -- Contact lens solutions.

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Bookmark on Lane
  • Select "Add to Favorites" (click “Continue” if you see a security alert)
  • From the "Create in" menu, select “Links” (IE7) or “Favorites Bar” (IE8, IE9) to install
  • Once installed it will look like this
  • Click "Bookmark on Lane" to bookmark any webpage
  • Your saved bookmark will appear on this page

Shortcut for iPhone

Lane Gateway to Licensed Content

  • Drag this button to your Safari bookmarks bar
  • Open iTunes and sync your iPhone; make sure "Sync Safari Bookmarks" under iPhone Info tab is selected
  • To invoke the bookmarklet on your iPhone, open Safari and tap the "Bookmarks" icon
  • Tap "Bookmarks Bar"
  • Tap "Lane Proxy Bookmarklet"

What is it?

This shortcut (Lane proxy bookmarklet) gives you access to resources licensed by the library even when you're not coming from a Lane or a Stanford IP address.

While we'd like Lane to be your gateway to our licensed content, we recognize that links to books, articles and journals come from a variety of different sources (Google, your email, RSS reader, etc.).

Lane Proxy Bookmarklet in the Bookmarks Bar

When installed, it will look your browser bookmark.

At the page you would like to proxy, click the "Lane Gateway to Licensed Content" to invoke it.

If Lane licenses that content, you'll get access as if you were on campus.

How does it work?

This shortcut (Lane proxy bookmarklet) is a combination of a browser bookmark and a JavaScript application. In other words, it's a bookmark that can be programmed to do things. The Lane proxy bookmarklet simply prepends the Lane proxy URL to the current URL in your browser.

This allows you to view the URL as though you were on campus, giving you access to materials licensed for use by the Stanford academic community.

If you're not authenticated, you'll be prompted for your SUNetID and password.

Don't see the Toolbar, Bookmarks, or Links or Favorites bar?

FireFox

From the "View" menu, select "Toolbars" & choose "Bookmarks Toolbar"

Safari

From the "View" menu, choose "Show Bookmarks Bar"

Chrome

From the "View" menu, choose "Always Show Bookmarks Bar"

Internet Explorer

IE controller bar
  • Right-click in a clear area near the browser address bar
  • In the menu, check a box next "Links" (IE7) or "Favorites Bar" (IE8, IE9)
  • Managing IE Favorites

Caveats

This shortcut (Lane proxy bookmarklet) only works with resources Lane has licensed and configured to work with our proxy server.

If invoked on a resource we do not license and/or have not yet configured, you will see an error message:

The Lane proxy server cannot complete your request because this host has not been configured properly.

We make no attempt to configure our proxy server for every resource, only those we license and for which a Stanford IP address grants access.

Drag this button onto your browser toolbar to install.

  • Right click this button
  • Select "Add to Favorites", click "Continue" if you see a security alert
  • In "Create in" menu, select "Links" (IE7) or "Favorites Bar" (IE8, IE9) to install

Drag this button onto Safari Bookmarks bar to install.

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