Books by Subject
- Abstracts of papers presented at the LXXIII Cold Spring Harbor Symposium on Quantitative Biology : control & regulation of stem cells, May 28-June 2, 2008 — Coding and decoding of calcium signals in plants (167)
- Color atlas of immunocytochemistry in diagnostic cytology — Koss's Cytology of the urinary tract with histopathologic correlations (167)
- Laboratory methods in cell biology : biochemistry and cell culture. 1st ed. — Plant cell wall : methods and protocols (167)
- Pluripotency in domestic animal cells — Zebrafish. Cellular and developmental biology. Part A. 3rd ed. (165)
- Abstracts of papers presented at the LXXIII Cold Spring Harbor Symposium on Quantitative Biology : control & regulation of stem cells, May 28-June 2, 20082008 Cold Spring Harb Lab PressGrodzicker, Terri; Stewart, David J.; Stillman, Bruce.
- 1972-PrintLane Catalog Record
- 2010 SpringerFujikawa, Denson G.
- 2007 Springer ProtocolsCoutts, Amanda S.
- 2013 Springer ProtocolsCoutts, Amanda S.
- 2010 SpringerStacey, Martin; Yona, Simon.The adhesion GPCRs : gene repertoire, phylogeny, and evolution / Helgi B. Schith, Karl J.V. Nordstrom, and Robert Fredriksson -- Cadherins : developmental roles and future challenges / Caroline J. Formstone -- Latrophilin signalling in tissue polarity and morphogenesis / Tobias Langenhan and Andreas P. Russ -- GPS proteolytic cleavage of adhesion-GPCRs / Hsi-Hsien Lin ... [et al.] -- The latrophilins : "split-personality" receptors / John-Paul Silva and Yuri A. Ushkaryov -- Studies on the very large G protein-coupled-receptor : from initial discovery to determining its role in sensorineural deafness in higher animals / D. Randy McMillan and Perrin C. White -- Adhesion-GPCRs in the CNS / Natalie Strokes and Xianhua Piao -- GPR56 interacts with extracellular matrix and regulates cancer progression / Lei Xu -- Adhesion-GPCRs in tumorigenesis / Gabriela Aust -- Immunity and adhesion-GPCRs / Simon Yona, Hsi-Hsien Lin, and Martin Stacey -- CD97 in leukocyte trafficking / Jorg Hamann ... [et al.] -- The role of CD97 in regulating adaptive T-cell responses / Ian Spendlove and Ruhcha Sutavani -- F4/80 : the macrophage specific adhesion-GPCR and its role in immunoregulation / Hsi-Hsien Lin ... [et al.] -- Signal transduction mediated through adhesion-GPCRs / Norikazu Mizuno and Hiroshi Itoh -- Emerging roles of brain specific angiogenesis inhibitor 1 / Daeho Park and Kodi S. Ravichandran -- Adhesion-GPCRs in the male reproductive tract / Ben Davies and Christiane Kirchhoff.
- 2011 SpringerRovensky, Yury A.Extracellular matrix -- Cytoskeleton -- Pseudopodia and adhesion structures -- Adhesive interactions of tissue cells with the extracellular matrix -- Cell migration -- Cell responses to chemical heterogeneity of substrata: adhesive islets or paths -- Topographic cell responses -- Intercellular adhesive interactions.
- 2011 SpringerIllouz, Yves-Gérard; Sterodimas, Aris.Cellular and Molecular Aspects of Adipose Tissue -- Isolation of Stem Cells from Human Adipose Tissue: Technique, Problems, and Pearls -- Principles of Liposuction -- Clinical Applications of Liposuction -- Principles of Autologous Fat Transplantation -- Clinical Applications of Autologous Fat Transplantation -- Adipose Stem Cells: From Liposuction to Adipose Tissue Engineering -- Storage of Adipose Stem Cells -- Engineered Scaffolds and Matrices: Tailored Biomaterials for Adipose Stem Cell Engineering -- Fundamentals and Principles of Biomolecules in Adipose Stem Cell Engineering -- Gene Therapy Used for Adipose Stem Cell Engineering -- Stem Cells from Human Adipose Tissue: A New Tool for Pharmacological Studies and for Clinical Applications -- Role of Adipose Stem Cells Therapy in Obesity -- Stem Cell Based Cardioregeneration and Adipose Tissue -- Adipose Stem Cell Engineering: Characterization and Current Application in Neurological Tissue Repair -- Adipose Stem Cell Engineering: Clinical Applications in Plastic and Reconstructive Surgery -- Orthopedic Use of Adipose-Derived Stem Cells -- Adipose-Derived Stem Cells: Characterization and Application in Urology -- Adipose Stem Cell Engineering: Characterization and Current Application in Otolaryngology -- Adipose Stem Cell Technologies for Tissue Regeneration in Dentistry -- Adipose Stem Cells, Tissue Engineering, and Solid Organ Transplantation and Regeneration -- Industrial Approaches to Adipose Stem Cells Engineering -- Future Research in Adipose Stem Cell Engineering -- Conclusions and Future Directions.
- 2013 SpringerKolonin, Mikhail G.Preface: Obesity, Adipose Tissue and Cancer Progression -- Metabolic Perturbations Associated with Adipose Tissue Dysfunction and the Obesity-Cancer Link -- Increased Adiposity and Colorectal Cancer -- Adiposity and Diabetes in Breast and Prostate Cancer -- Increased Adipocity and Endometrial Cancer Risk -- Adipokines: Soluble Factors from Adipose Tissue Implicated in Cancer -- Animal Models to Study the Interplay between Cancer and Obesity -- Unraveling the local influence of tumor-surrounding adipose tissue on tumor progression: cellular and molecular actors involved -- Trafficking of Cells from Adipose Tissue to Tumor Microenvironment -- The Impact of Obesity Intervention on Cancer: Clinical Perspectives -- Index.
- 2012 SpringerSymonds, Michael E.1. Adipocyte Precursors: Developmental Origins, Self-Renewal, and Plasticity / Christian Dani and Nathalie Billon -- 2. Adipocyte Differentiation / José María Moreno-Navarrete and José Manuel Fernández-Real -- 3. Brown Adipose Tissue / Martin Klingenspor and Tobias Fromme -- 4. White Adipose Tissue / Stephane Gesta and C. Ronald Kahn -- 5. Sex Differences in Body Fat Distribution / Alain Veilleux and André Tchernof -- 6. Macrophages and Inflammation / Elise Dalmas, Joan Tordjman, Michèle Guerre-Millo, and Karine Clément -- 7. Adipocyte Growth and Factors Influencing Adipocyte Life Cycle / Srujana Rayalam and Clifton A. Baile -- 8. The Evolution of Mammalian Adipose Tissue / Caroline M. Pond -- 9. Dietary Determinants of Fat Mass and Body Composition / María A. Zulet, María J. Moreno-Aliaga, and J. Alfredo Martínez -- 10. The Genetic Determinants of Common Obesity-Susceptibility / Ruth J.F. Loos -- 11. Early Origins of Obesity and Developmental Regulation of Adiposity / Shalini Ojha and Helen Budge.
- 2008 Springer ProtocolsYang, Kaiping.
- 2011 Springer ProtocolsBunnell, Bruce A.; Gimble, Jeffrey M.Isolation and culture of rhesus adipose-derived stem cells -- Isolation of human adipose-derived stem cells from lipoaspirates -- Isolation of murine adipose-derived stem cells -- In vitro adult rat adipose tissue-derived stromal cell isolation and differentiation -- In vitro adult canine adipose tissue-derived stromal cell growth characteristics -- Adipogenic differentiation of adult equine mesenchymal stromal cells -- Isolation and culture of porcine adipose tissue-derived somatic stem cells -- Automated isolation and processing of adipose-derived stem and regenerative cells -- Methods for the purification and characterization of human adipose-derived stem cells -- Characterization of human adipose-derived stem cells using flow cytometry -- Evaluation of cellular and humoral immune responses to allogeneic adipose-derived stem/stromal cells -- Adipose-derived stromal cells: Cytokine expression and immune cell contaminants -- Gel-based and gel-free proteomic technologies -- Adipogenic differentiation of adipose-derived stem cells -- Three-dimensional culture systems to induce chondrogenesis of adipose-derived stem cells -- Neural differentiation of human adipose tissue-derived stem cells -- Osteogenic differentiation strategies for adipose-derived mesenchymal stem cells -- Generation of adipose stromal cell-derived hepatic cells -- Adipose stem cell differentiation into smooth muscle cells -- Endothelial and cardiac regeneration from adipose tissues -- Epithelial differentiation of human adipose-derived stem cells -- Screening for epigenetic target genes that enhance reprogramming using lentiviral-delivered shRNA -- Adipogenic differentiation of human adipose-derived stem cells on 3D silk scaffolds -- A first approach for the production of human adipose tissue-derived stromal cells for therapeutic use -- Viral transduction of adipose-derived stem cells -- Use of adipose-derived stem cells in high-throughput screening to identify modulators of lipogenesis -- Preservation protocols for human adipose tissue-derived adult stem cells -- Soft tissue reconstruction -- Methods for analyzing microRNA expression and function during osteogenic differentiation of human adipose tissue-derived mesenchymal stem cells -- The generation and the manipulation of human multipotent adipose-derived stem cells -- Cell sheet technology for tissue engineering: The self-assembly approach using adipose-derived stromal cells -- Differentiation of adipose-derived stem cells for tendon repair -- Adipose-derived stem cells for skin regeneration -- Adipose-derived stem cells for periodontal tissue regeneration.
- 2012 SpringerTurksen, Kursad.
- 2006 ScienceDirectKlimanskaya, Irina; Lanza, R. P.Ectoderm -- Mesoderm -- Endoderm -- Extraembryonic and perinatal stem cells.
- 2011 SpringerPhinney, Donald G.Basic Biology of Adult Stem Cells -- Molecular Mechanisms Regulating Adult Stem Cell Self-Renewal -- Maintenance of Adult Stem Cells: Role of the Stem Cell Niche -- The Emerging Role of microRNAs in Adult Stem Cells -- Expression and Function of Pluripotency Genes in Adult Stem Cells -- Adult Stem Cell Plasticity Revisited --Characterization of Adult Stem Cells -- Lineage Tracing of Tissue-Specific Stem Cells In Vivo -- Surrogate Measures of Adult Stem Cell Self-Renewal: The Neural Stem Cell Paradigm -- ABC Transporters, Aldehyde Dehydrogenase, and Adult Stem Cells -- Regulation of Life Span and Immortalization -- Regulation of Life Span in Adult Stem Cells -- The Cancer Stem Cell Paradigm.
- 2015 KargerRudolph, K. Lenhard.Speakers at the symposium -- Stem cells in adult intestine / Feng, J., Sperka, T. -- Molecular mechanisms of muscle stem cell aging / Schwërer, S., Tümpel, S. -- Mechanism of functional alterations in hematopoietic stem cell aging / Morita, Y. -- The microenvironment, aging, and disease / Geiger, H. -- Sestrins in aging and metabolism / Tang, D., Tao S. -- Telomeres and stem cell aging / Felix, D.A. -- DNA damage and checkpoint responses in adult stem cells / Romanov, V., Shukla, A., Ju, Z.
- 2010 CRCnetBASEMarkov, Marko; Miklavčič, Damijan; Pakhomov, Andrei G."A reflection of the intense study of the effects of electromagnetic fields on living tissues that has taken place during the last several decades, this book discusses the theoretical and experimental evidence and considerations the effects of strong electromagnetic fields and/or electric pulses and their importance in medicine and biology. The authors present the basic techniques applied in electroporation and the advanced methods for creation of nanopores, highlighting their basic science and clinical applications. Topics include nano electroporation, classic electroporation, experimental evidence for electroporation of living cells, and electroporation for cancer and wound healing"--Provided by publisher.
- v. 177-, 2005- SpringerAlso available: Print – v. 47-97, 99-156, 171, 1973-2000, 2003.
- 2012 SpringerGiardina, B.; Mordente, Alvaro; Scatena, Roberto.1. Cancer Stem Cells: A Revisitation of the "Anaplasia" Concept / Roberto Scatena -- 2. Stem Cells and Cancer Stem Cells: New Insights / Toru Kondo -- 3. Molecular Biology of Cancer Stem Cells / Oswaldo Keith Okamoto -- 4. Biomarkers of Cancer Stem Cells / Jun Dou and Ning Gu -- 5. Cancer Stem Cells and the Microenvironment / Alfonso Colombatti, Carla Danussi, Eliana Pivetta, and Paola Spessotto -- 6. Leukemia Stem Cells / Steven W. Lane and David A. Williams -- 7. Cancer Stem Cells and the Central Nervous System / Serdar Korur, Maria Maddalena Lino, and Adrian Merlo -- 8. Cancer Stem Cells and Glioblastoma Multiforme: Pathophysiological and Clinical Aspects / Akio Soeda, Mark E. Shaffrey, and Deric M. Park -- 9. Breast Cancer Stem Cells / Nuria Rodríguez Salas, Enrique González González, and Carlos Gamallo Amat -- 10. Colon Cancer Stem Cells / Ugo Testa -- 11. Liver Tumor-Initiating Cells/Cancer Stem Cells: Past Studies, Current Status, and Future Perspectives / Kwan Ho Tang, Stephanie Ma, and Xin-Yuan Guan -- 12. Pancreatic Cancer Stem Cells / Erica N. Proctor and Diane M. Simeone -- 13. Cancer Stem Cells and Renal Carcinoma / Benedetta Bussolati and Giovanni Camussi -- 14. Cancer Stem Cells: Proteomic Approaches for New Potential Diagnostic and Prognostic Biomarkers / Patrizia Bottoni, Bruno Giardina, and Roberto Scatena -- 15. Cancer Stem Cells: An Innovative Therapeutic Approach / Roberto Scatena, Patrizia Bottoni, Alessandro Pontoglio, Salvatore Scarà, and Bruno Giardina -- 16. Cancer Stem Cell and ATP-Binding Cassette: Which Role in Chemoresistance? / Andrea Silvestrini, Elisabetta Meucci, Giuseppe Ettore Martorana, Bruno Giardina, and Alvaro Mordente -- 17. Stem Cells and Cancer Stem Cells: Biological and Clinical Interrelationships / Cinzia Bagalà and Carlo Barone -- 18. Immunomodulatory Functions of Cancer Stem Cells / Tobias Schatton, Jennifer Y. Lin, and Markus H. Frank.
- 2012 SpringerBottoni, Patrizia; Giardina, B.; Scatena, Roberto.
- 2011 SpringerAdams, Niall M.; Freemont, Paul S.
- 2012 KargerRudolph, K. Lenhard.Speakers at the symposium / Morita, M. -- Aging of the niche and the microenvironment and its role in stem cell aging / Geiger, H. -- Hematopoietic stem cell aging and cancer / Chen, Y., Ju, Z. -- DNA damage, checkpoint responses, and cell cycle control in aging stem cells / Kleinhans, K.N., Burkhalter, M.D. -- Hematopoietic stem cell aging and fate decision / Illing, A., Morita, Y. -- Stem cell therapy and stress response in pancreas and intestine -- Sperka, T., Omrani, O. -- Niche-stem cell interations and environmental influences / Tang, D. -- Stem cells and metabolism / Missios, P., Guachalla, L. -- Molecular mechanisms of muscle stem cell aging / Baig, A.H., Tümpel, S. -- Neural stem cells in development and aging / Schmidt-Strassburger, U.
- 2012 SpringerAghdami, Nasser; Baharvand, Hossein.Advances in stem cell research discusses recent advances in stem cell science, including therapeutic applications. This volume covers such topics as biomanufacturing iPS cells for therapeutic applications, techniques for controlling stem cell fate decisions, as well as current basic research in such areas as germ line stem cells, genomics and proteomics in stem cell research. It is a useful book for biology and clinical scientists, especially young investigators and stem cell biology students who are newly entering the world of stem cells research. The editors hope that the new knowledge and research outlined in this book will help contribute to new therapies for a wide variety of diseases that presently afflict humanity.
- 2011 SpringerFeldmann, Marc; Kovalenko, Andrew; Wallach, David.Roles of the TNF family in tissue homeostasis and normal development -- Novel aspects of signaling activation by the TNF family: novel aspects of the functions of the TRAFs and cIAPs -- Novel aspects of signaling activation by the TNF: ubiquitin modification of signaling proteins -- Novel aspects of signaling activation by the TNF family: TNF signaling and gene regulatory networks -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: roles of the TNF family in infectious diseases -- Roles of the TNF family in infectious diseases and interrelationship of the TNF family and pattern recognition receptor signaling: interrelationship of the TNF family and pattern recognition receptor signaling -- Novel aspects of immune regulation by the TNF family -- Control of lymphocyte function and repertoire by the TNF family -- Advances in applying our knowledge to therapy: mechanisms of pathological and therapeutic effects of the TNF family -- Advances in applying our knowledge to therapy: rational design of new means for therapeutic modulation of function of the TNF family -- Roles of the TNF family in neuronal development, function, and pathology -- Cell death mechanisms controlled by the TNF family -- Contributors to abstracts of talks and posters at the 12th TNF Conference -- Abstracts of talks and posters presented at the 12th TNF Conference.
- 2014 KargerFülöp, Tamas; Robert, Ladislas.The Commitment of human cells to senescence / R. Holliday -- Evolutionary theories of aging can explain why we age / E. Le Bourg -- Control of cell replication during aging / A. Macieira-Coelho -- Cell senescence : role in aging and age-related diseases / J. Campisi, L. Robert, -- Aging of cell membranes : facts and theories / I. Zs.-Nagy -- Oxidative stress, mitochondrial dysfunction, and the mitochondria theory of aging / Y. Kong, S.E. Trabucco, H. Zhang -- Aging of connective tissues : experimental facts and theoretical considerations / J. Labat-Robert, L. Robert -- Aging of cell communication : loss of receptor function / L. Robert, T. Fulop -- On the immunological theory of aging / T. Fulop, J.M. Witkowski, G. Pawelec, C. Alan, A. Larbi -- Aging of the brain, dementias, role of infectious proteins : facts and theories / F. Morinet -- Aging as alteration / P.-A. Miquel -- Longevity and its regulation : centenarians and beyond / L. Robert, T. Fulop.
- 2012 SpringerBreitenbach, Michael; Jazwinski, S. Michal; Laun, Peter (Cell biologist).Introduction -- Oxidative stresses and ageing -- The role of mitochondria in the aging processes of yeast -- The retrograde response and other pathways of interorganelle communication in yeast replicative aging -- Chronological aging in Saccharomyces cerevisiae -- Aging and the survival of quiescent and non-quiescent cells in yeast stationary-phase cultures -- Maximising the yeast chronological lifespan -- Amino acid homeostasis and chronological longevity in Saccharomyces cerevisiae -- DNA damage and DNA replication stress in yeast models of aging -- Yeast aging and apoptosis -- Cellular homeostasis in fungi: impact on the aging process -- Genome-wide analysis of yeast aging -- Genetic approaches to aging in budding and fission yeasts: new connections and new opportunities -- Evolution of asymmetric damage segregaton: a modelling approach -- Cellular ageing and the actin cyoskeleton.
- 2007Pincus, Zachary S.
- 2007Enders, George C.; Klein, Robert M.
- 2010Enders, George C.; Klein, Robert M.
- Angiogenesis modulations in health and disease : practical applications of pro- and antiangiogenesis targets2013 SpringerDavis, Paul J.; Mousa, Shaker A.This book is a major update of novel targets in angiogenesis modulation, including pro- and anti-angiogenesis. There is in-depth coverage of preclinical and clinical methods and models, investigational status, and clinical applications. The impact of nanotechnology in advancing the applications of pro-and anti-angiogenesis strategies is also highlighted, along with stem cell and biotechnologies in research and development of angiogenesis modulating targets.
- 2015 SpringerAl-Rubeai, Mohamed.Animal cells are the preferred "cell factories" for the production of complex molecules and antibodies for use as prophylactics, therapeutics or diagnostics. Animal cells are required for the correct post-translational processing (including glycosylation) of biopharmaceutical protein products. They are used for the production of viral vectors for gene therapy. Major targets for this therapy include cancer, HIV, arthritis, cardiovascular and CNS diseases and cystic fibrosis. Animal cells are used as in vitro substrates in pharmacological and toxicological studies. This book is designed to serve as a comprehensive review of animal cell culture, covering the current status of both research and applications. For the student or R&D scientist or new researcher the protocols are central to the performance of cell culture work, yet a broad understanding is essential for translation of laboratory findings into the industrial production. Within the broad scope of the book, each topic is reviewed authoritatively by experts in the field to produce state-of-the-art collection of current research. A major reference volume on cell culture research and how it impacts on production of biopharmaceutical proteins worldwide, the book is essential reading for everyone working in cell culture and is a℗ℓrecommended volume for all biotechnology libraries.
- Animal cell technology, basic & applied aspects : proceedings of the 19th Annual Meeting of the Japanese Association for Animal Cell Technology (JAACT), Kyoto, Japan, September 25-28, 20062009 SpringerIkura, Kōji.
- 2010 CRCnetBASEPreedy, Victor R.
- 2009 SpringerRosado, Juan Antonio; Salido, Gines Maria.
- 2009 SpringerChen, George G.; Lai, Paul B. S.
- 2010 SpringerCecconi, Francesco; D'Amelio, Marcello.
- 2009 Springer
- 2012 SpringerGonzalez, Constancio; Nurse, Colin A.; Peers, C.; Prabhakar, Nanduri R.
- 2009 SpringerGonzalez, Constancio; Nurse, Colin A.; Peers, C.
- 2009 SpringerHaydon, Philip G.; Parpura, Vladimir.
- 2007 SpringerMacieira-Coelho, Alvaro.
- 2014 SpringerDomanski, Henryk A.This book covers all of the diagnostic areas where FNAC is used today. This includes palpable lesions and lesions sampled using various radiological methods, and correlations with ancillary examinations detailed on an entity-by-entity basis. As well as being a complete atlas of the facts and findings important to FNAC, this atlas is a guide to diagnostic methods that optimize health care. The interaction of the cytologist or cytopathologist with other specialists (radiologists, oncologists and surgeons) involved in the diagnosis and treatment of patients with suspicious mass lesions is emphasized and illustrated throughout. ? With contributions from experts in the field internationally and abundant colour images Atlas of Fine Needle Aspiration Cytology provides a comprehensive and up-to-date guide to FNAC for pathologists, cytopathologists, radiologists, oncologists, surgeons and others involved in the diagnosis and treatment of patients with suspicious mass lesions.
- 2012 SpringerAmit, M.; Itskovitz-Eldor, Joseph.
- 2012 SpringerKomuro, Terumasa.Part 1. Distribution and arrangement of ICC in the GI tract -- Stomach -- Small Intestine -- Duodenum -- Colon -- Caecum -- Ileocaecal Junction -- ICC Found in the Submucosal Layer -- Introduction -- Part 2. Ultrastructural demonstration of ICC and the allied cells -- Ultrastructural Demonstration of ICC -- Signal Pathways Between Nerves and Muscles Not Mediated by ICC -- Issues for Future Studies.
- 2002 ScienceDirectHörber, J. K. Heinrich; Jena, Bhanu P.Also available: Print – 2002
- v. 1-, 2014 ScienceDirectv. 2, 2014 ScienceDirectv.3, 2014 ScienceDirectHayat, M. A.Volume 1. Molecular mechanisms -- Volume 2. Role in general diseases -- Volume 3. Mitophagy.
- 2013 SpringerWang, Hong-Gang.This book covers the latest advances in the field of autophagy and cancer from the basics of the molecular machinery for autophagy induction and regulation up to current areas of interest, including modulation of autophagy and drug discovery for cancer prevention and treatment. The reader will be initially introduced to the historical context of autophagy, followed by a summary of the key players in autophagy, a discussion on the origin of autophagosomes, and an overview of signal transduction regulation of autophagy. The next chapters deal with the complex relationship between autophagy and tumorigenesis through in-depth discussions of how autophagy influences cell survival, apoptosis, inflammation, immunity, tumor microenvironment, metabolic stress, DNA damage, and genomic instability. The remaining chapters discuss how autophagy affects cancer cell response to therapy and how to best modulate autophagy for therapeutic benefit - what to target and how to target. We hope that this monograph will be an invaluable reference source for professionals, students, postdoctoral fellows, and senior scientists working in the fields of autophagy and cancer.
- 2009 ScienceDirectKlionsky, Daniel J.
- 2009 SpringerDeretic, Vojo; Levine, Beth; Yoshimori, Tamotsu.
- 2009 ScienceDirectKlionsky, Daniel J.
- 2008 ScienceDirectKlionsky, Daniel J.
- 2013 Springer ProtocolsDelcour, Anne H.Bird's eye view of the bacterial landscape / Natividad Ruiz -- Visualizing the bacterial cell surface : an overview / Harald Engelhardt -- Purification of the outer membrane usher protein and periplasmic chaperone-subunit complexes from the P and type 1 pilus systems / Nadine S. Henderson and David G. Thanassi -- Experimental manipulation of the microbial functional amyloid called curli / Yizhou Zhou [and others] -- Visualization of gram-positive bacterial pili / Chungyu Chang [and others] -- Single cell microfluidic studies of bacterial motility / Adrien Ducret, Olivier Theodoly, and Tam Mignot -- Chromatographic analysis of the Escherichia coli polysialic acid capsule / Susan M. Steenbergen and Eric R. Vimr -- Analysis of exopolysaccharides in Myxococcus xanthus using confocal laser scanning microscopy / Wei Hu, Renate Lux, and Wenyuan Shi -- Assessment of multidrug efflux assemblies by surface plasmon resonance / Elena B. Tikhonova and Helen I. Zgurskaya -- Fluorescence microscopy and proteomics to investigate subcellular localization, assembly, and function of the type II secretion system / Tanya L. Johnson [and others] -- Pore formation by T3SS translocators : liposome leakage assay / Eric Faudry, Caroline Perdu, and Ina Attree -- Isolation of bacterial type IV machine subassemblies / Mayukh K. Sarkar [and others] -- Production and crystallization of bacterial type V secretion proteins / Hye-Jeong Yeo -- Assembly of bacterial outer membrane proteins / Jan Grijpstra, Martine P. Bos, and Jan Tommassen -- Outer membrane of gram-negative bacteria : lipid A isolation and characterization / Jessica V. Hankins [and others] -- Quantitative and qualitative preparations of bacterial outer membrane vesicles / Halima Chutkan [and others] -- In vitro peptidoglycan synthesis assay with lipid II substrate / Jacob Biboy, Nhat Khai Bui, and Waldemar Vollmer -- Extraction of cell wall-bound teichoic acids and surface proteins from Listeria monocytogenes / Filipe Carvalho [and others] -- Subfractionation and analysis of the cell envelope (lipo) polysaccharides of Mycobacterium tuberculosis / Anna E. Grzegorzewicz and Mary Jackson -- Protein disulfide bond formation in the periplasm : determination / Katleen Denoncin [and others] -- Using reporter genes and the Escherichia coli ASKA overexpression library in screens for regulators of the gram negative envelope stress response / Julia L. Wong, Stefanie L. Vogt, and Tracy L. Raivio -- Isolation of bacteria envelope proteins / Shu Quan [and others] -- Patch clamp electrophysiology for the study of bacterial ion channels in giant spheroplasts of E. coli / Boris Martinac [and others] -- Electrophysiological characterization of bacterial pore-forming proteins in planar lipid bilayers / Owen S. Mapingire, Beau Wager, and Anne H. Delcour.
- 2011 SpringerBooss, Bernhelm.pt. 1. Systems biology approach to [beta]-cells -- pt. 2. Imaging and sensors -- pt. 3. Genetics and proteomics -- pt. 4. Physiological, pharmaceutical and clinical applications and perspectives -- pt. 5. Mathematical modelling and numerical simulation.
- Bethesda system for reporting cervical cytology : definitions, criteria, and explanatory notes. Third edition [3rd ed.].2015 SpringerNayar, Ritu; Wilbur, David C.This book offers clear, up-to-date guidance on how to report cytologic findings in cervical, vaginal and anal samples in accordance with the 2014 Bethesda System Update. The new edition has been expanded and revised to take into account the advances and experience of the past decade. A new chapter has been added, the terminology and text have been updated, and various terminological and morphologic questions have been clarified. In addition, new images are included that reflect the experience gained with liquid-based cytology since the publication of the last edition in 2004. Among more than 300 images, some represent classic examples of an entity while others illustrate interpretative dilemmas, borderline cytomorphologic features or mimics of epithelial abnormalities. The Bethesda System for Reporting Cervical Cytology, with its user-friendly format, is a must have for pathologists, cytopathologists, pathology residents, cytotechnologists, and clinicians.
- 2015 SpringerKarimi-Busheri, Feridoun.1. Integration, networking, and global biobanking in the age of new biology -- 2. The future of biobanking: a conceptual look at how biobanks can respond to the growing human biospecimen needs of researchers -- 3. Sustainability of biobanks in the future -- 4. Biobanking: the future of cell preservation strategies -- 5. Biobanking for personalized medicine -- 6. A global view of breast tissue banking -- 7. Biobanking of cerebrospinal fluid for biomarker analysis in neurological diseases -- 8. Biobanking in the twenty-first century: driving population metrics into biobanking quality -- 9. Challenges in developing a cancer oriented-biobank: experience from a 17 year-old cancer biobank in Sao Paulo, Brazil -- 10. China biobanking -- 11. Establishing an iso-compliant modern cancer-biobank in a developing country: a model for international cooperation -- 12. Nursing and biobanking -- 13. A data-centric strategy for modern biobanking -- 14. The importance of quality patient advocacy to biobanks: a lay perspective from Independent Cancer Patients Voice (ICPV), based in United Kingdom -- Index.
- 2015 SpringerChakrabarti, Abhijit; Surolia, Avadhesha.Consists of critical reviews and original research papers from the 2014 International Symposium on the "Biochemical Role of Eukaryotic Cell Surface Macromolecules". Topics covered include: · neurochemical and biochemical analysis of cell surface glycoconjugates · membrane skeletal organization · GPCRs and other receptors · biophysical approaches to study membrane interactions · glycoconjugate metabolism · dysregulation · molecular mechanisms involved in cell-cell and cell-matrix interaction · glycans in infectious and neurological diseases · cancer and glycosyltransferases as drug targets.
- 2012 SpringerSudhakaran, Perumana R.; Surolia, Avadhesha.Glycomics: An Overview of the Complex Glycocode / Garima Gupta and Avadhesha Surolia -- Structural Glycomic Approaches to Molecular Recognition Events on Cell Surfaces / Koichi Kato -- ISCSM2011 Chondroitin Sulfate E-type Structure at Tumor Cell Surface Is Involved in Experimental Metastasis / Kazuyuki Sugahara and Shuji Mizumoto -- Chondroitin Sulfate-Specific Novel Hydrolase in Human / Shuhei Yamada -- Identification of Endothelial Cell Surface Carbohydrate-Binding Receptors by Carbohydrate Ligand Mimicry Peptides / Michiko N. Fukuda -- Lysosomal Enzyme Sorting Receptors - Where Did They First Appear in the Animal Kingdom? / Suryanarayanaraju Vegiraju, Suresh Koduru and Siva Kumar Nadimpalli -- Endoplasmic Reticulum-Targeted Bcl-2 Inhibitable Mitochondrial Fragmentation Initiates ER Stress-Induced Cell Death / B. C. Bhavya, Deepa Indira, Mahendra Seervi, Jeena Joseph and Praveen K. Sobhan, et al. -- Interactions Between Caveolin-1 and Sphingolipids, and Their Functional Relevance / Sandro Sonnino, Simona Prioni, Vanna Chigorno and Alessandro Prinetti -- Cell Membrane Repair Pathway Involves Sensing of Dynamics of Caveolae and Caspase-1 / Saumya S. Srivastava and M. V. Krishnasastry -- Angiogenic Response of Endothelial Cells to Fibronectin / V. B. S. Kumar, R. I. Viji, M. S. Kiran and Perumana R. Sudhakaran -- Lactosylceramide Synthase as a Therapeutic Target to Mitigate Multiple Human Diseases in Animal Models / Subroto Chatterjee and Nezar Alsaeedi -- Advanced FRET Methodologies: Protein-Lipid Selectivity Detection and Quantification / Fábio Fernandes, Manuel Prieto and Luís M. S. Loura -- Mechanism of GPCR-Directed Autoantibodies in Diseases / Hamiyet Unal, Rajaganapathi Jagannathan and Sadashiva S. Karnik -- Role of Membrane Cholesterol in Leishmanial Infection / Amitabha Chattopadhyay and Md. Jafurulla -- How Intact Is the Basement Membrane? Role of MMPs / S. Asha Nair, Sankar Jagadeeshan, Ramachandran Indu, Perumana R. Sudhakaran and M. R. Pillai -- Apoptosis of Breast Cancer Cells: Modulation of Genes for Glycoconjugate Biosynthesis and Targeted Drug Delivery / Subhash Basu, Rui Ma, Joseph R. Moskal, Manju Basu and Sipra Banerjee -- Altered Expression of Sialidases in Human Cancer / Taeko Miyagi, K. Takahashi, S. Moriya, K. Hata and K. Yamamoto, et al. -- Poly-ADP-Ribosylation of Vascular Endothelial Growth Factor and Its Implications on Angiogenesis / S. Binu, S. J. Soumya, V. B. S. Kumar and Perumana R. Sudhakaran -- Sphingolipid-Binding Domain in the Serotonin1A Receptor / Amitabha Chattopadhyay, Yamuna Devi Paila, Sandeep Shrivastava, Shrish Tiwari and Pushpendra Singh, et al. -- Withanolide D, Carrying the Baton of Indian Rasayana Herb as a Lead Candidate of Antileukemic Agent in Modern Medicine / Susmita Mondal, Saptarshi Roy, Rita Maity, Asish Mallick and Rajender Sangwan, et al. -- Engineered Glucose to Generate a Spectroscopic Probe for Studying Carbohydrate Biology / Ashish Tripathi, Vibha Singh, K. G. Aishwarya, Gopala Krishna Aradhyam and Srinivas Hotha -- Changes in Sialic Acid Content of Jelly Coat in Pesticide-Exposed Frog Eggs and Their Influence on Fertilization / H. P. Gurushankara, S. V. Krishnamurthy and V. Vasudev.
- 2005 WileyKrauss, Gerhard.The regulation of gene expression -- The regulation of enzyme activity -- Structure and function of signal pathways -- Signaling by nuclear receptors -- G protein-coupled signal transmission pathways -- Intracellular messenger substance : second messengers -- Ser/Thr-specific protein kinases and protein phosphates -- Signal transmission via transmembrane receptors with tyrosine-specific protein kinase activity -- Signal transmission via ras proteins -- Intracellular signal transduction : the protein cascades of the MAP kinase pathways -- Membrane receptors with associated tyrosine kinase activity -- Other receptor classes -- Regulation of the cell cycle -- Malfunction of signaling pathways and tumorigenesis : oncogenes and tumor suppressor genes -- Apoptosis.
- 2005 SpringerMullins, Chris.Theory of organelle biogenesis : a historical perspective / Barbara M. Mullock and J. Paul Luzio -- Protein coats as mediators of intracellular sorting and organelle biogenesis / Chris Mullins -- The role of proteins and lipids in organelle biogenesis in the secretory pathway / Thomas F.J. Martin -- Endoplasmic reticulum biogenesis : proliferation and differentiation / Erik Snapp -- The golgi apparatus : structure, function and cellular dynamics / Nihal Altan-Bonnet and Jennifer Lippincott-Schwartz -- Lysosome biogenesis and dynamics / Diane McVey Ward, Shelly L. Shiflett and Jerry Kaplan -- Nucleogenesis / Sui Huang -- Mitochondrial biogenesis / Danielle Leuenberger, Sean P. Curran and Carla M. Koehler -- The biogenesis and cell biology of peroxisomes in human health and disease / Stanley R. Terlecky and Paul A. Walton.
- 2010 SpringerLuzi, Livio; Codella, Roberto.
- 2006 SpringerCallow, J. A.; Smith, Andrew M.
- 2013 Springer ProtocolsTollefsbol, Trygve O.Cell Senescence Culturing Methods / Huaping Chen, Yuanyuan Li, and Trygve O. Tollefsbol -- Digital Image Analysis of Cells Stained with the Senescence-Associated b-Galactosidase Assay / Liran I. Shlush and Sara Selig -- Analysis of Biomarkers of Caloric Restriction in Aging Cells / Yuanyuan Li and Trygve O. Tollefsbol -- Cell Sorting of Young and Senescent Cells / Graeme Hewitt, Thomas von Zglinicki, and Joã̃o F. Passos -- Studying the Replicative Life Span of Yeast Cells / David A. Sinclair -- Methods for Creating Mutations in C. elegans That Extend Lifespan / Dayong Wang, Min Cao, Jessica Dinh, and Yuqing Dong -- Aging Studies in Drosophila Melanogaster / Yaning Sun, Jason Yolitz, Cecilia Wang, Edward Spangler, Ming Zhan, and Sige Zou -- The Use of Calorie Restriction Mimetics to Study Aging / Munehiro Kitada and Daisuke Koya -- Using Somatic-Cell Nuclear Transfer to Study Aging / Satoshi Kishigami, Ah Reum Lee, and Teruhiko Wakayama -- Induction of Cellular Senescence by Oncogenic RAS / Romi Gupta and Narendra Wajapeyee -- Methods of Cellular Senescence Induction Using Oxidative Stress / Zhe Wang, Dandan Wei, and Hengyi Xiao -- Methods of Testing Pharmacological Drugs Effects on Aging and Life Span in Mice / Vadimir N. Anisimov, Irina G. Popovich, and Mark A. Zabezhinski -- Mitochondria-Targeted Antiaging Gene Therapy with Adeno-associated Viral Vectors / Dejia Li and Dongsheng Duan -- Real-Time Bioluminescence Functional Imaging for Monitoring Tissue Formation and Regeneration / Nadav Bleich Kimelman, Ilan Kallai, Dmitriy Sheyn, Wafa Tawackoli, Zulma Gazit, Gadi Pelled, and Dan Gazit -- Exometabolomic Mapping of Caenorhabditis elegans: A Tool to Noninvasively Investigate Aging / Robert J. Mishur, Jeffrey A. Butler, and Shane L. Rea -- Detecting Polymorphisms in Human Longevity Studies: HLA Typing and SNP Genotyping by Amplicon Sequencing / Gilberto Vargas-Alarcón and Carmina Flores-Domı́nguez -- Gel Electrophoresis-Based Proteomics of Senescent Tissues / Steven Carberry and Kay Ohlendieck -- Single-Cell Semiconductor Sequencing / Andrea B. Kohn, Tatiana P. Moroz, Jeffrey P. Barnes, Mandy Netherton, and Leonid L. Moroz -- Application of DNA Microarray Technology to Gerontological Studies / Kiyoshi Masuda, Yuki Kuwano, Kensei Nishida, and Kazuhito Rokutan -- Epigenetic Biomarker to Determine Replicative Senescence of Cultured Cells / Carmen M. Koch and Wolfgang Wagner -- Single-Neuron Transcriptome and Methylome Sequencing for Epigenomic Analysis of Aging / Leonid L. Moroz and Andrea B. Kohn
- 2007 Springer ProtocolsTollefsbol, Trygve O.
- 2015 SpringerHoek, Jan B.; Seitz, H. K.; Vasiliou, Vasilis; Zakhari, Samir.In recent years, a significant amount of research has emerged connecting the link between alcohol and cancer. The field has rapidly advanced, especially since the complex connection between alcohol and cancer has several unique sub areas that are being investigated and this volume gives a comprehensive overview of these advancements.
- 2009 SpringerZipori, Dov.
- 2012 SpringerRőszer, Tamás.This book fills in a gap in the NO literature. Recent progress in the field of NO-biology shows that NO is generated within distinct cell compartments, including specific plasma membrane regions, mitochondria, chloroplasts, peroxisomes, the Golgi-complex and intracellular membrane systems. NO synthesis plays specific roles in these compartments and, in turn, cell organelles also control intracellular NO levels. This monograph focuses on the roles played by the subcellular NO-signaling microdomains in the prokaryote-, fungus-, plant- and animal cells and shows how NO behaves as an intracellular signal in distinct cellular environments. This monograph also provides a summary of our knowledge on how NO synthesis came through evolution to be associated with organelles and subcellular compartments. Promotes the novel ideas that some functions of NO and its associations with subcellular units have been conserved during the evolution of the cell. A special chapter is dedicated to the biomedical relevance of subcellular NO synthesis, and this chapter also discusses the evidence that altered compartmentalization of NO-producing enzymes causes disease.
- 2014 Cambridge2014 KnovelMa, Peter X."Written by world-leading experts, this book focusses on the role of biomaterials in stem cell research and regenerative medicine. Emphasising basic principles and methodology, it covers stem cell interactions, fabrication technologies, design principles, physical characterisation and biological evaluation, across a broad variety of systems and biomaterials. Topics include: stem cell biology, including embryonic stem cells, IPS, HSC and progenitor cells; modern scaffold structures, including biopolymer, bioceramic, micro- and nanofiber, ECM and biohydrogel; advanced fabrication technologies, including computer-aided tissue engineering and organ printing; cutting-edge drug delivery systems and gene therapy techniques; medical applications spanning hard and soft tissues, the cardiovascular system and organ regeneration. With a contribution by Nobel laureate Shinya Yamanaka, this is a must-have reference for anyone in the field of biomaterials, stem cell biology and engineering, tissue engineering and regenerative medicine"--Provided by publisher.
- 2015 ScienceDirectPaluch, Ewa K.
- 2008 ScienceDirectCorreia, John J.; Detrich, H. William.
- 2008 ScienceDirectCorreia, John J.; Detrich, H. William.
- 2010 SpringerCancro, M. P.
- 2012 Springer ProtocolsHelfrich, Miep H.; Ralston, Stuart.Primary human osteoblast cultures / Jane P. Dillon [and others] -- Osteoblast isolation from murine calvaria and long bones / Astrid D. Bakker and Jenneke Klein-Nulend -- Rat osteoblast cultures / Isabel R. Orriss, Sarah E.B. Taylor, and Timothy R. Arnett -- Isolation of primary avian osteocytes / Cor M. Semeins, Astrid D. Bakker, and Jenneke Klein-Nulend -- Isolation of mouse osteocytes using cell fractionation for gene expression analysis/ Christine Halleux [and others] -- Studying osteocyte function using the cell lines MLO-Y4 and MLO-A5 / Jennifer Rosser and Lynda F. Bonewald -- Isolation, differentiation, and characterisation of skeletal stem cells from human bone marrow in vitro and in vivo / Rahul S. Tare [and others] -- Rodent osteoclast cultures / Isabel R. Orriss and Timothy R. Arnett -- Isolation and culture of primary chicken osteoclasts / Patricia Collin-Osdoby and Philip Osdoby -- Isolation and purification of rabbit osteoclasts / Fraser P. Coxon, Michael J. Rogers, and Julie C. Crockett -- Generation of human osteoclasts from peripheral blood / Kim Henriksen [and others] -- Osteoclast formation in mouse co-cultures / Cecile Itzstein and Robert J. Van 't Hof -- RANKL-mediated osteoclast formation from murine RAW 264.7 cells / Patricia Collin-Osdoby and Philip Osdoby -- Transfection of osteoclasts and osteoclast precursors / Julie C. Crockett, David J. Mellis, and Adam Taylor -- Analysis of signalling pathways by western blotting and immunoprecipitation / Aymen I. Idris -- Analysis of transcriptional regulation in bone cells / Huilin Jin and Stuart H. Ralston -- Extraction of nucleic acids from bone / Alun Hughes, Tracy L. Stewart, and Val Mann -- Analysis of gene expression in bone by quantitative RT/PCR / Alun Hughes -- Histomorphometry in rodents / Reinhold G. Erben and Martin Glösmann -- Studying gene expression in bone by in situ hybridization / Ina Kramer [and others] -- Immunostaining of skeletal tissues / Tobias B. Kurth and Cosimo De Bari -- Techniques for the study of apoptosis in bone / Sudeh Riahi and Brendon Noble -- Transmission electron microscopy of bone / Vincent Everts [and others] -- Scanning electron microscopy of bone / Alan Boyde -- Fluorescence imaging of osteoclasts using confocal microscopy / Fraser P. Coxon -- Live imaging of bone cell and organ cultures / Sarah L. Dallas and Patricia A. Veno -- Analysis of bone architecture in rodents using microcomputed tomography / Robert J. van 't Hof -- Bone measurements by peripheral quantitative computed tomography in rodents / Jürg A. Gasser and Johannes Willnecker -- Quantitative X-ray imaging of rodent bone by Faxitron / J.H. Duncan Bassett [and others] -- Bioluminescence imaging of bone metastasis in rodents / Thomas J.A. Snoeks [and others] -- Fourier transform infrared imaging of bone / Eleftherios P. Paschalis -- Raman microscopy of bone / Simon R. Goodyear and Richard M. Aspden -- The calvarial injection assay / Robert J. van 't Hof -- Ovariectomy/orchidectomy in rodents / Aymen I. Idris -- Mechanical properties of bone ex vivo / Simon R. Goodyear and Richard M. Aspden -- Mechanical stimulation of bone cells using fluid flow / Carmen Huesa and Astrid D. Bakker -- Using cell and organ culture models to analyze responses of bone cells to mechanical stimulation / Andrew A. Pitsillides and Simon C.F. Rawlinson -- In vivo mechanical loading / Roberto Lopes de Souza and Leanne Saxon.
- 2009 SpringerGiordano, Antonio; Normanno, Nicola.
- 2007 SpringerAli, Syed Z.; Parwani, Anil V.
- 2015 ScienceDirectMarshall, Wallace F.; Ross, Jennifer.Chapter 1. In vitro systems for the study of microtubule-based cell polarity in fission yeast -- Chapter 2. Microtubules, MAPs, and motor patterns -- Chapter 3. Self-organization of motors and microtubules in lipid-monolayered droplets -- Chapter 4. Reconstitution of microtubule-based motility using cell extracts -- Chapter 5. Building cells for quantitative, live-cell analyses of collective motor protein functions -- Chapter 6. Reconstituting cytoskeletal contraction events with biomimetic actin-myosin active gels -- Chapter 7. Building an artificial actin cortex on microscopic pillar arrays -- Chapter 8. Triggering actin polymerization in Xenopus egg extracts from phosphoinositide-containing lipid bilayers -- Chapter 9. Reconstituting geometry-modulated protein patterns in membrane compartments -- Chapter 10. Structural and functional studies of membrane remodeling machines -- Chapter 11. Building interconnected membrane networks -- Chapter 12. Using supported bilayers to study the spatiotemporal organization of membrane-bound proteins -- Chapter 13. Reconstituting ParA/ParB-mediated transport of DNA cargo -- Chapter 14. Cell-sized liposomes that mimic cell motility and the cell cortex -- Chapter 15. Reconstitution of cortical actin networks within water-in-oil emulsions -- Chapter 16. Engineering artificial cells by combining HeLa-based cell-free expression and ultrathin double emulsion template -- Chapter 17. Reconstitution of proteins on electroformed giant unilamellar vesicles -- Chapter 18. Reconstituting SNARE-mediated membrane fusion at the single liposome level.
- 2012 ScienceDirectRothman, Joel H.; Singson, Andrew.An updated edition of the classic Methods in Cell Biology volume 48, this book emphasizes diverse methods and technologies needed to investigate C. elegans, both as an integrated organism and as a model system for research inquiries in cell, developmental, and molecular biology, as well as in genetics and pharmacology. By directing its audience to tried-and-true and cutting-edge recipes for research, this comprehensive collection is intended to guide investigators of C. elegans for years to come.
- 2011 ScienceDirectRothman, Joel H.; Singson, Andrew.Pt.I Genetics and functional genomics : Mapping mutations in C. elegans / Eric J. Lambie -- Specialized chromosomes and their uses in caenorhabditis elegans / Martin R. Jones, Zoe Lohn, Ann M. Rose -- Genome engineering by transgene-instructed gene conversion in C. elegans / Valérie J.P. Robert, Jean-Louis Bessereau -- RNAi methods and screening : RNAi based high-throughput genetic interaction screening / Patricia G. Cipriani, Fabio Piano -- Dissection of genetic pathways in C. elegans / Zheng Wang, David R. Sherwood -- Pt.II Molecular biology and biochemistry : Transgenesis in C. elegans / Vida Praitis, Morris F. Maduro -- RNA processing in C. elegans / J. Jason Morton, Thomas Blumenthal -- Analysis of microRNA expression and function / Priscilla M. Van Wynsberghe, Shih-Peng Chan, Frank J. Slack, Amy E. Pasquinelli -- In situ hybridization of embryos with antisense RNA probes / Gina Broitman-Maduro, Morris F. Maduro -- Gene-centered regulatory network mapping / Albertha J.M. Walhout -- Affinity purification of protein complexes in C. elegans / Esther Zanin, Julien Dumont, RetoGassmann, Iain Cheeseman, Paul Maddox, Shirin Bahmanyar, Ana Carvalho, Sherry Niessen, John R. Yates III, Karen Oegema, Arshad Desai -- Pt.III Development : Cell indentification and cell lineage analysis / Claudiu A. Giurumescu, Andrew D. Chisholm -- The genetics and cell biology of fertilization / Brian D. Geldziler, Mathew R. Marcello, Diane C. Shakes, Andrew Singson -- Imaging embryonic morphogenesis in C. elegans / Jeff Hardin -- Molecular and genetic approaches for the analysis of C. elegans neuronal development / Dong Yan, Yishi Jin -- Methods for evaluating the caenorhabditis elegans dauer state : standard dauer-formation assay using synthetic daumones and proteomic analysis of O-GIcNAc modifications / Jeeyong Lee, Kwang-Youl Kim, Kyoe-Jin Joo, Keekyeong Kim, Pan-Young Jeong, Young-Ki Paik.
- 2012 SpringerYee-Ki, Lee; Chung-Wah, Siu.Calcium Handling in hiPSC-Derived Cardiomyocytes -- Myocardial Infarction and Heart Failure -- Embryonic Stem Cells/Pluripotent Stem Cells -- Human Induced Pluripotent Stem Cell (hiPSC)-Derived Cardiomyocytes as a Source for Cardiac Regeneration -- Spontaneous Cardiac Differentiation -- Mesoderm Enrichment by Wnt-Signaling Growth Factors -- Endoderm-Like Cell (END)-2 Co-culture Method -- Calcium Homeostasis in Cardiomyocytes -- Sarcoplasmic Reticulum (SR) Governs Maturity of Cardiomyocytes -- SR Junctional Proteins Play a Role in Calcium Flux Between Cytosol and SR -- Spatial and Temporal Ca2+ Wavefront Dictated by T-Tubule Structure -- IP3-Mediated Calcium Release Contributes to Whole-Cell Calcium Transients -- Calcium Handling Properties of hES-Derived Cardiomyocytes -- Calcium Handling Properties of hiPSC-Derived Cardiomyocytes -- iPSC-Derived Cardiomyocyte as a Potential Platform for Disease Modeling of the Impaired Calcium Handling-Related Syndrome -- Disease Modeling of Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) -- Mitochondrial Dysfunction-Related Cardiomyopathy-Impaired SR Ca2+ Reuptake -- Measurement of Cytosolic [Ca2+] by Fluorescence Confocal Microscopy -- Materials -- Calibration of Fluo-3 -- Isolation of hiPSC- and hESC-Derived Cardiomyocytes -- Recording of Cytosolic [Ca2+] -- RT-qPCR of Calcium Handling Proteins.
- 2010 ScienceDirectWhitaker, M. J.Chapter 1. A Practical Guide to the Preparation of Ca2+ Buffers / Donald M. Bers, Chris W. Patton, Richard Nuccitelli -- Chapter 2. Photorelease Techniques for Raising or Lowering Intracellular Ca2+ / Robert Zucker -- Chapter 3. Making and Using Calcium-Selective Mini- and Microelectrodes / L. Hove-Madsen, S. Baudet, D.M. Bers -- Chapter 4. Construction, Theory, and Practical Considerations for using Self-referencing of Ca2+-Selective Microelectrodes for Monitoring Extracellular Ca2+ Gradients / Mark A. Messerli, Peter J.S. Smith -- Chapter 5. Practical Aspects of Measuring Intracellular Calcium Signals with Fluorescent Indicators / Joseph P.Y. Kao, Gong Li, Darryl A. Auston -- Chapter 6. Genetically Encoded Probes for Measurement of Intracellular Calcium / Michael Whitaker -- Chapter 7. Patch Clamp Methods for Studying Calcium Channels / David L. Armstrong, Christian Erxleben, Jody A. White -- Chapter 8. Nuclear Patch-Clamp Recording from Inositol 1,4,5-Trisphosphate Receptors / Taufiq Rahman, Colin W. Taylor -- Chapter 9. Confocal and Multiphoton Imaging of Intracellular Ca2+ / Godfrey Smith, Martyn Reynolds, Francis Burton, Ole Johan Kemi -- Chapter 10. The Use of Aequorins to Record and Visualize Ca2+ Dynamics: From Subcellular Microdomains to Whole Organisms / Sarah E. Webb, Kelly L. Rogers, Eric Karplus, Andrew L. Miller.
- 2010 Springer ProtocolsPetersen, O. H.; Verkhratskiĭ, A. N.Principles of the CA2+ homeostatic/signalling system / A. Verkhratsky and O.H. Petersen -- CA2+ recordings: Hardware and software (from microscopes to cameras) / E.C. Toescu and J. Graham -- CA2+ imaging: Principles of analysis and enhancement / F. Mammano and M. Bortolozzi -- Bioluminescent CA2+ indicators / L. Fedrizzi and M. Brini -- Monitoring calcium levels with genetically encoded indicators / O. Garaschuk and O. Griesbeck -- Intracellular calcium-sensitive microelectrodes / R.C. Thomas -- CA2+ caging and uncaging / S.H. Kim and M.K. Park -- CA2+ imaging of intracellular organelles: Endoplasmic reticulum / R. Blum, O.H. Petersen and A. Verkhratsky -- CA2+ imaging of intracellular organelles: Mitochondria / L. Núñez [and others] -- CA2+ imaging of dendrites and spines / K. Holthoff -- In vivo CA2+ imaging of the living brain using multi-cell bolus loading technique / G. Eichhoff [and others] -- CA2+ imaging of glia / C. Lohr and J.W. Deitmer.
- 2012 SpringerIslam, Md. Shahidul."This volume ... [explores] topics ranging from the fundamental aspects of calcium signaling to its varied clinical implications. It presents comprehensive discussion of cutting-edge research alongside detailed analysis of critical issues, at the same time as setting out testable hypotheses that point the way to future scientific endeavors. The contributions feature material on theoretical and methodological topics as well as related subjects including mathematical modeling and simulations. They examine calcium signaling in a host of contexts, from mammalian cells to oocytes, zebrafish and plants. With much of interest to newcomers to the field as well as seasoned experts, this new publication is both wide-ranging and authoritative." --Excerpt from publisher's description.
- 2013 SpringerKaestner, Lars.Summary -- Introduction -- Direct evidence - the digital approach -- Fluorescence-based visualisation -- Aequorin-based measurements -- Measurement of calcium transport across membranes -- Molecular biology based approaches -- Manipulation of calcium -- Calcium-induced function -- Calcium signalling in cardiac myocytes -- Calcium signalling in red blood cells -- Perspective -- Calcium Signalling Methodology -- Non-linear and ultra high-speed imaging for explorations of the murine and human heart -- A system for optical high resolution screening of electrical excitable cells -- Concepts for optical high content screens of excitable primary isolated cells -- A primary culture system for sustained expression of a calcium sensor in preserved adult rat ventricular myocytes -- Calcium imaging of individual erythrocytes: Problems and approaches -- Calcium Signalling in Cardiac Myocytes -- Reduced Cardiac L-Type Ca²+ Current in Cav€ ₂ -/- Embryos Impairs Cardiac Development and Contraction With Secondary Defects in Vascular Maturation -- Overexpression of junctin causes adaptive changes in cardiac myocyte Ca²+ signaling -- Remodelling of Ca²+ handling organelles in adult rat ventricular myocytes during longterm culture -- Functional and morphological preservation of adult ventricular myocytes in culture by sub-micromolar cytochalasin D supplement -- Calcium Signalling in Red Blood Cells -- The non-selective voltage-activated cation channel in the human red blood cell membrane: reconciliation between two conflicting reports and further characterisation -- Ion channels in the human red blood cell membrane: Their further investigation and physiological relevance -- Prostaglandin E₂ activates channelmediated calcium entry in human erythrocytes: An indication for a blood clot formation supporting process -- Functional NMDA receptors in rat erythrocytes -- Stimulation of human red blood cells leads to Ca²+-mediated intercellular adhesion -- Lysophospatidic acid induced red blood cell aggregation in vitro -- Regulation of phosphatidylserine exposure in red blood cells -- Cation Channels in Erythrocytes - Historical and Future Perspective.
- 2007 SpringerBrini, Marisa; Carafoli, Ernesto.Annexinopathies / M.J. Hayes ... [et al.] -- Calpains and human disease / I. Bertipaglia and E. Carafoli -- Gelsolin and diseases / L. Spinardi and W. Witke -- Guanylate cyclase-activating proteins and retina disease / W. Baehr and K. Palczewski -- Pathologies involving the S100 proteins and rage / C.W. Heizmann ... [et al.] -- The calcium-sensing receptor: Physiology, pathophysiology and CaR-based therapeutics / E.M. Brown -- Physiological roles of the Ca2+/CaM-dependent protein kinase cascade in health and disease / J. Colomer and A.R. Means -- Calcium channelopathies: Voltage-gated calcium channels / P.J. Adams and T.P. Snutch -- TRP channels in disease / S.E. Jordt and B.E. Ehrlich -- Diseases associated with altered ryanodine receptor activity / W.J. Durham ... [et al.] -- Inositol 1,4,5-tripshosphate receptor, calcium signalling and Huntington's disease / I. Bezprozvanny -- SERCA pumps and human diseases / A. Hovnanian -- The plasma membrane calcium ATPase and disease / B.L. Tempel and D.J. Shilling -- Diseases involving the Golgi calcium pump / J. Vanoevelen ... [et al.] -- Calcium signalling and cancer cell growth / T. Capiod ... [et al.] -- Calcium misregulation and the pathogenesis of muscular dystrophy / F.W. Hopf ... [et al.] -- Calcium and cell death / A. Verkhratsky -- Calcium and cell death: The mitochondrial connection / P. Bernardi and A. Rasola -- Role of calcium in the pathogenesis of Alzheimer's disease and transgenic models / K.N. Green ... [et al.] -- Calcium and cardiomyopathies / E.G. Kranias and D.M. Bers -- Calcium signalling and calcium transport in bone disease / H.C. Blair ... [et al.].
- 2015 Springer ProtocolsZaccolo, Manuela.Simultaneous assessment of cAMP signaling events in different cellular compartments using FRET-based reporters / Alex Burdyga and Konstantinos Lefkimmiatis -- Recording intracellular cAMP levels with EPAC-based FRET sensors by fluorescence lifetime imaging / Marcel Raspe, Jeffrey Klarenbeek, and Kees Jalink -- Novel approach combining real-time imaging and the patch-clamp technique to calibrate FRET-based reporters for cAMP in their cellular microenvironment / Andreas Koschinski and Manuela Zaccolo -- Structure-based, in silico approaches for the development of novel cAMP FRET reporters / Matías Machado and Sergio Pantano -- Automated image analysis of FRET signals for subcellular cAMP quantification / Silas J. Leavesley [and others] -- Channel-based reporters for cAMP detection / Thomas C. Rich [and others] -- Imaging sub-plasma membrane cAMP dynamics with fluorescent translocation reporters / Anders Tengholm and Olof Idevall-Hagren -- Adenoviral transduction of FRET-based biosensors for cAMP in primary adult mouse cardiomyocytes / Oliver Lomas [and others] -- Generation of transgenic mice expressing FRET biosensors / Daniela Hübscher and Viacheslav O. Nikolaev -- Photoactivatable adenylyl cyclases (PACs) as a tool to study cAMP signaling in vivo : an overview / Marina Efetova and Martin Schwärzel -- Selective disruption of the AKAP signaling complexes / Eileen J. Kennedy and John D. Scott -- Screening for small molecule disruptors of AKAP-PKA interactions / Carolin Schächterle [and others] -- Structure-based bacteriophage screening for AKAP- selective PKA regulatory subunit variants / Ryan Walker-Gray and Matthew G. Gold -- Yeast-based high-throughput screen for modulators of phosphodiesterase activity / Ana Santos de Medeiros and Charles S. Hoffman -- Separation of PKA and PKG signaling nodes by chemical proteomics / Eleonora Corradini, Albert J.R. Heck, and Arjen Scholten -- Development of computational models of cAMP signaling / Susana R. Neves-Zaph and Roy S. Song.
- 2011 Springer ProtocolsCree, Ian A.Xenotransplantation of breast cancers -- Feeder layers: Co-culture with nonneoplastic cells -- Drug design and testing: Profiling of antiproliferative agents for cancer therapy using a cell-based methyl-[3h]-thymidine incorporation assay -- Transfection and DNA-mediated gene transfer -- Analysis of drug interactions -- Development of rituximab-resistant B-NHL clones: An in vitro model for studying tumor resistance to monoclonal antibody-mediated immunotherapy -- Proteomic evaluation of cancer cells: Identification of cell surface proteins -- Measuring gene expression from cell cultures by quantitative reverse-transcriptase polymerase chain reaction -- Expression analysis of homeobox genes in leukemia/lymphoma cell lines -- Flow cytometric DNA analysis of human cancers and cell lines -- Angiogenesis assays -- Cell migration and invasion assays -- Molecular breakpoint analysis of chromosome translocations in cancer cell lines by long distance inverse-PCR -- Measurement of DNA damage in individual cells using the Single Cell Gel Electrophoresis (Comet) assay -- Purification of annexin V and its use in the detection of apoptotic cells -- Real-time cytotoxicity assays -- Differential staining cytotoxicity assay: A review -- Cell sensitivity assays: The ATP-based tumor chemosensitivity assay -- Cell sensitivity assays: The MTT assay -- Cellular chemosensitivity assays: An overview -- Isolation of endothelial cells from human tumors -- Isolation of inflammatory cells from human tumours -- Establishment and culture of leukemia-lymphoma cell lines -- Isolation and culture of ovarian cancer cells and cell lines -- Isolation and culture of squamous cell carcinoma lines -- Isolation and culture of melanoma and naevus cells and cell lines -- Isolation and culture of colon cancer cells and cell lines -- Generation of lung cancer cell line variants by drug selection or cloning -- Quality assurance and good laboratory practice -- Elimination of mycoplasmas from infected cell lines using antibiotics -- Detecting mycoplasma contamination in cell cultures by polymerase chain reaction -- Cell culture contamination -- Cytogenetic analysis of cancer cell lines -- Online verification of human cell line identity by STRDNA typing -- Characterization and authentication of cancer cell lines: An overview -- Storage of cell lines -- Principles of cancer cell culture -- Cancer biology.
- 2011 SpringerDranoff, Glenn.Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
- Cancer microenvironment and therapeutic implications : tumor pathophysiology mechanisms and therapeutic strategies2009 SpringerBaronzio, Gian Franco; Cogle, Christopher R.; Fiorentini, G.
- 2007 SpringerHaendler, B.; Mumberg, D.; Wiestler, O. D.
- 2011 SpringerAllan, Alison Lawrie.Cancer stem cells : historical perspectives and lessons from leukemia / Christopher R. Cogle -- Cancer stem cells in breast cancer / Jenny E. Chu and Alison L. Allan -- Cancer stem cells in brain cancer / Xin Wang, Chitra Venugopal, and Sheila K. Singh -- Cancer stem cells in colorectal cancer / Mauro Biffoni, Eros Fabrizi, and Lucia Ricci-Vitiani -- Cancer stem cells in pancreatic cancer / Jorge Dorado, Alicia G. Serrano, and Christopher Heeschen -- Cancer stem cells in prostate cancer / Paula Kroon ... [et al.] -- Cancer stem cells in melanoma / Ping Jin ... [et al.] -- Cancer stem cells in lung cancer / Jun Shen and Feng Jiang -- Cancer stem cells in ovarian cancer / Fang Fang ... [et al.] -- Cancer stem cells in hepatocellular cancer / Russell C. Langan and Itzhak Avital -- Cancer stem cells in head and neck cancer / Mark E.P. Prince and Samantha J. Davis -- Relationship between regulatory pathways in pluripotent stem cells and human tumors / Olga Gaidarenko and Yang Xu -- Influence of the embryonic microenvironment on tumor progression / Daniela Quail ... [et al.] -- The epithelial-to-mesenchymal transition and cancer stem cells / Jonas Fuxe -- Application of stem cell assays for the characterization of cancer stem cells / Pamela M. Willan and Gillian Farnie -- Zebrafish as a model to study stem cells in development, disease, and cancer / Viviana Anelli, Cristina Santoriello, and Marina C. Mione -- Imaging cancer stem cells / Paula Foster -- Mouse models for studying normal and cancer stem cells / David A. Hess -- Cancer stem cells and disease prognosis / Zeshaan A. Rasheed, Jeanne Kowalski, and William H. Matsui -- Mechanisms of radioresistance in cancer stem cells / Cleo Y-F Lee and Maximilian Diehn -- The role of ABC transporters in cancer stem cell drug resistance / Vera S. Donnenberg, Ludovic Zimmerlin, and Albert D. Donnenberg -- Resistance to endocrine therapy in breast cancer : are breast cancer stem cells implicated? / Ciara S. O'Brien ... [et al.] -- Future directions : cancer stem cells as therapeutic targets / Alysha K. Croker and Alison L. Allan -- Final thoughts : complexity and controversy surrounding the "cancer stem cell" paradigm / Craig Gedye, Richard P. Hill, and Laurie Ailles.
- 2015 Springer ProtocolsFerran, Maureen C.; Skuse, Gary R.This volume has been assembled for scientists interested in basic and applied biomedical research directed toward understanding the development, genetics, and function of cardiomyocytes. The methods and protocols contained within it address cell culture techniques, cardiomyocyte differentiation and redifferentiation, experimental induction of cardiomyopathies, introducing genes into cardiomyocytes, genomic approaches to the understanding cardiomyocytes, cryopreservation of neonatal cardiomyocytes, and modeling of cardiomyocyte function. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and current, Cardiomyocytes: Methods and Protocols explores complimentary areas of cardiomyocyte science that, taken together, can inform individuals with a broad range of interests.
- 2012 SpringerFrank, Philippe G.; Jasmin, Jean-François; Lisanti, Michael P.Lipid rafts, caveolae, and GPI linked proteins / Valerie L. Reeves, Candice M. Thomas, and Eric J. Smart -- Caveolae and the regulation of endocytosis / Anna L. Kiss -- Caveolin : role in cell signaling / Cecile Boscher and Ivan Robert Nabi -- Regulation of ENOS in caveolae / Chieko Mineo and Philip W. Shaul -- Recent developments in the interactions between caveolin and pathogens / Fabiana S. Machado ... [et al.] -- Caveolin and breast cancer : a new clinical perspective / Isabelle Mercier and Michael P. Lisanti -- Caveolin and prostate cancer progression / Michael R. Freeman, Wei Yang, and Dolores Di Vizio -- Caveolins and caveolae, roles in insulin signalling, and diabetes / Peter Strolfors -- Atherosclerosis, caveolae, and caveolin / Stephanos Pavlides ... [et al.] -- Caveolins and heart diseases / Mathivadhani Panneerselvam, Hemal H. Patel, and David M. Roth -- Caveolins and lung function / Nikolaos A. Maniatis ... [et al.].
- 2006 SpringerCress, Anne E.; Nagle, Raymond B.
- 2014 SpringerBehl, Christian; Ziegler, Christine.Aging and cell aging : an introduction -- Cell cycle : the life cycle of a cell -- Theories and mechanisms of aging -- Selected age-related disorders.
- 2013 SpringerSchatten, Heide.Histopathology and grading of breast cancer / Magda Esebua -- Multicentric/multifocal breast cancer : overview, biology, and therapy / Federico Buggi ... [et al.] -- Immune system in breast cancer initiation and progression : role of epithelial to mesenchymal transition / Keith L. Knutson and Erik C. Radisky -- Remodelling of the extracellular matrix : implication for cancer / Thomas R. Cox and Janine T. Erler -- Biology and treatment of basal-like breast cancer / Bingchen Han ... [et al.] -- Re-excision after lumpectomy for breast cancer / Suzanne B. Coopey -- Novel anti-angiogenic therapies using naturally occurring and synthetic drugs to combat progestin-dependent breast cancer / Salman M. Hyder, Benford Mafuvadze, and Cynthia Besch-Williford -- New insights on estrogen receptor actions in hormone-responsive breast cancer cells by interaction proteomics / Concetta Ambrosino ... [et al.] -- Reprogramming breast cancer cells with embryonic microenvironments : insights from nodal signaling / Gina Kirsammer and Mary J.C. Hendrix - Metastatic determinants : breast tumour cells in circulation / Nisha Kanwar and Susan J. Done -- Breast cancer epigenetics : biomarkers and therapeutic potential / Nancy H. Nabilsi ... [et al.] -- Impact of centrosome abnormalities on breast cancer development and progression with a focus on targeting centrosomes for breast cancer therapy / Heide Schatten -- New perspective on cyclin D1 : beyond cell cycle regulation / Chenguang Wang, Timothy G. Pestell, and Richard G. Pestell -- Gene signatures of inflammatory breast cancer : epithelial plasticity and a cancer stem cell phenotype / Fredika M. Robertson ... [et al.] -- Integrated human mammary epithelial cell culture system for studying carcinogenesis and aging / Martha R. Stampfer, Mark A. LaBarge, and James C. Garbe -- New breast cancer treatment considerations a brief review of the use of genetically modified (attenuated) bacteria as therapy for advanced and metastatic breast cancer / Robert A. Kazmierczak ... [et al.].
- 2007 SpringerBock, Ralph.
- 2002 ScienceDirectMatsumoto, Brian.Also available: Print – 2002
- 2006 ScienceDirectCelis, J. E.
- 2010 SpringerMeshorer, Eran; Plath, Kathrin.Early embryonic cell fate decisions in the mouse / Yojiro Yamanaka and Amy Ralston -- Nuclear architecture in stem cells / Kelly J. Morris, Mita Chotalia, and Ana Pombo -- Epigenetic regulation of pluripotency / Eleni M. Tomazou and Alexander Meissner -- Autosomal lyonization of replication domains during early mammalian development / Ichiro Hiratani and David M. Gilbert -- Preservation of genomic integrity in mouse embryonic stem cells / Peter J. Stambrook and Elisia D. Tichy -- Transcriptional regulation in embryonic stem cells / Jian Chien, Dominic Heng, and Huck Hui Ng -- Alternative splicing in stem cell self renewal and differentiation / David A. Nelles and Gene W. Yeo -- MicroRNA regulation of embryonic stem cell self renewal and differentiation / Collin Melton and Robert Blelloch -- Telomeres and telomerase in adult stem cells and pluripotent embryonic stem cells / Rosa M. Marión and Maria A. Blasco -- X chromosome inactivation and embryonic stem cells / Tahsin Stefan Barakat and Joost Gribnau -- Adult stem cells and their niches / Francesca Ferraro, Cristina Lo Celso, and David Scadden -- Adult stem cell differentiation and trafficking and their implications in disease / Ying Zhuge, Zhao-Jun Liu, and Omaida C. Velazquez -- Vertebrates that regenerate as models for guiding stem cells / Christopher L. Antos and Elly M. Tanaka -- Reprogramming of somatic cells to pluripotency / Masato Nakagawa and Shinya Yamanaka.
- 2009 SpringerKoenig, Edward.
- 2006 SpringerGundelfinger, Eckart D.; Schraven, Burkhart; Seidenbecher, Constanze I.
- 2002 CRCnetBASELehr, Claus-Michael.
- 2011 Springer ProtocolsAschner, Michael; Bal-Price, Anna; Suñol, Cristina.Guidance on Good Cell Culture Practice (GCCP) -- Induced Pluripotent Stem Cells (iPSCs): An Emerging Model System for the Study of Human Neurotoxicology -- Neural Stem Cells -- Primary Cultures for Neurotoxicity Testing -- Preparation and Use of Serum-Free Aggregating Brain Cell Cultures for Routine Neurotoxicity Screening -- Cell Culture to Investigate Neurotoxicity and Neurodegeneration Utilizing Caenorhabditis elegans -- Modeling the Blood-Brain Barrier -- In vitro Models of the Blood-Cerebrospinal Fluid Barrier and Their Use in Neurotoxicological Research -- Introducing Cloned Genes into Cultured Neurons Providing Novel In vitro Models for Neuropathology and Neurotoxicity Studies -- P19 Embryonic Carcinoma Cell Line: A Model To Study Gene-Environment Interactions -- Signal Transduction and Neurotoxicity: What Can We Learn from Experimental Culture Systems? -- Neurite Degeneration in Human Neuronal SH-SY5Y Cells as an Indicator of Axonopathy -- The Use of Differentiating N2a and C6 Cell Lines for Studies of Organophosphate Toxicity -- Assessing Toxic Injuries of Experimental Therapeutics to the Crystalline Lens Using Lens Explant Culture -- Necrosis, Apoptosis, and Autophagy: Mechanisms of Neuronal and Glial Cell Death -- Inflammation and Reactive Oxygen/Nitrogen Species in Glial/Neuronal Cultures -- Neuronal Oxidative Injury and Biomarkers of Lipid Peroxidation -- Analysis of Protein Targets by Oxidative Stress Using the Oxyblot and Biotin-Avidin-Capture Methodology -- Catecholaminergic Cell Lines for the Study of Dopamine Metabolism and Neurotoxicity -- 13C NMR Spectroscopy and Mass Spectrometry Analysis of Intermediary Metabolism in Cultured Neural Cells -- Culture Models for the Study of Amino Acid Transport and Metabolism -- Neurotransmitter Transporters and Anticonvulsant Drug Development -- Ion Channel Electrophysiology in Cultured Neurons -- Neurotoxicity Assessment by Recording Electrical Activity from Neuronal Networks on Microelectrode Array Neurochips -- GABAA Receptor Binding and Ion Channel Function in Primary Neuronal Cultures for Neuropharmacology/Neurotoxicity Testing.
- 2005 CRCnetBASEHu, Wei-Shou; Ozturk, Sadettin S.
- 2010 SpringerEnders, Greg H.Part I: Starting the Cell Division Cycle -- 1 Escape from Cellular Quiescence -- 2 Interplay Between Cyclin-Dependent Kinases and E2F-Dependent Transcription -- 3 Regulation of Pre-RC Assembly: A Complex Symphony Orchestrated by CDKs -- Part II: Proliferation Under Duress -- 4 Mitotic Checkpoint and Chromosome Instability in Cancer -- 5 Mitotic Catastrophe -- 6 p53, ARF, and the Control of Autophagy -- Part III: Long-Term Proliferation -- 7 Regulation of Self-Renewing Divisions in Normal and Leukaemia Stem Cells -- 8 Maintenance of Telomeres in Cancer -- 9 The Senescence Secretome and Its Impact on Tumor Suppression and Cancer -- Part IV: Applications in Preventing and Treating Cancer -- 10 Cell Cycle Deregulation in Pre-neoplasia: Case Study of Barrett8217;s Oesophagus -- 11 Targeting Cyclin-Dependent Kinases for Cancer Therapy -- Index.
- Cell cycle exit in G1 and differentiation independent of the Retinoblastoma gene family during development2010Wirt, Stacey Ellen; Artandi, Steven E.; McConnell, Susan K.; Sage, Julien; Wong, Albert J.The ability of stem/progenitor cells to exit the cell cycle is essential for proper embryonic development, but the mechanisms governing cell cycle exit are still not fully understood. Correct regulation of G1 is critical for ensuring proper organismal development, tissue homeostasis, and tumor suppression. The Retinoblastoma (Rb) gene family is composed of three genes, Rb, p107, and p130, which are collectively thought to serve as essential regulators of the G1 phase of the cell cycle in most proliferating cell types. The Rb family has also been implicated in promoting the gene expression of several differentiation programs in different cell lineages. However, due to the overlapping and compensatory functions among the Rb family members, a complete understanding of how the Rb family controls the cell cycle and differentiation programs within a cell remains unclear. Furthermore, it has not yet been tested whether the Rb family members are the only mediators of these cellular processes, or if there are alternative mechanisms for cell cycle exit and differentiation in mammalian stem and progenitor cells. Here we tested the requirement for the Rb protein and its family members p107 and p130 in G1 arrest and differentiation in mammalian cells. We employed several strategies to conditionally remove the Rb family genes in entire embryos and in specific neural lineages, as well as multiple differentiation systems in vitro. We found that Rb family triple knock-out (TKO) mouse embryos survive until days 9-11 of gestation, with similar patterning and organogenesis as seen in wild type embryos. Strikingly, a number of TKO cells, including in the neural lineage, are able to exit the cell cycle in G1 and fully differentiate in vivo and in culture. This ability of TKO cells to arrest in G1 is associated with the repression of key cell cycle target genes for E2F and Myc transcription factors. Thus, G1 arrest can be achieved independently of Rb family members, illustrating the robustness of cell cycle regulatory networks during embryogenesis, and identifying a novel program that regulates cell cycle exit in G1 in mammalian cells.
- 2011 SpringerKubiak, Jacek Z.
- 2016 Springer ProtocolsCoutts, Amanda S.; Weston, Louise.
- 2006 SpringerKaldis, Philipp.
- 2010 SpringerGalderisi, Umberto; Giordano, Antonio.
- 2011 Springer ProtocolsBánfalvi, Gáspár.1. Overview of cell synchronization / Gaspar Banfalvi -- 2. Synchronization of mammalian cells and nuclei by centrifugal elutriatio / Gaspar Banfalvi -- 3. Cytofluorometric purification of diploid and tetraploid cancer cells / Maria Castedo, Lorenzo Galluzzi, Ilio Vitale, Laura Senovilla, Didier Métivier, Mohamed Jèmaà, Santiago Rello-Varona, and Guido Kroemer -- 4. Large-scale mitotic cell synchronization / Kalyan Dulla and Anna Santamaria -- 5. Synchronization of mammalian cell cultures by serum deprivation / Thomas J. Langan and Richard C. Chou -- 6. Cell synchronization by inhibitors of DNA replication induces replication stress and DNA damage response: analysis by flow cytometry / Zbigniew Darzynkiewicz, H. Dorota Halicka, Hong Zhao, and Monika Podhorecka -- 7. Chromosome formation during fertilization in eggs of the teleost oryzias latipes / Takashi Iwamatsu -- 8. Specific cell cycle synchronization with butyrate and cell cycle analysis / Congjun Li -- 9. Analysis of nuclear uracil-DNA glycosylase (nUDG) turnover during the cell cycle / Jennifer A. Fischer and Salvatore Caradonna -- 10. Synchronization of HeLa cells / Hoi Tang Ma and Randy Y. C. Poon -- 11. Synchronization of Bacillus subtilis cells by spore germination and outgrowth / Gasper Banfalvi -- 12. Synchronization of yeast / Arkadi Manukyan, Lesley Abraham, Huzefa Dungrawala, and Brandt L. Schneider -- 13. Synchronization of pathogenic protozoans / Staffan Svärd and Karin Troell -- 14. Synchronization of in vitro maturation porcine oocytes / Tamas Somfai and Yuji Hirao -- 15. Synchronization of medicago sativa cell suspension culture / Ferhan Ayaydin, Edit Kotogány, Edit Ábrahám, and Gábor V. Horváth -- 16. Cell cycle synchronization for the purpose of somatic cell nuclear transfer (SCNT) / Yoel Shufaro and Benjamin E. Reubinoff -- 17. Ex vivo expansion of haematopoietic stem cells to improve engraftment in stem cell transplantation / Kap-Hyoun Ko, Robert Nordon, Tracey A. O'Brien, Geoff Symonds, and Alla Dolnikov -- 18. Flow cytometry developments and perspectives in clinical studies: examples in ICU patients / Fabienne Venet, Caroline Guignant, and Guillaume Monneret -- 19. Molecular network dynamics of cell cycle control: transitions to start and finish / Attila Csikász-Nagy, Alida Palmisano, and Judit Zámbprszky.
- 2011 SpringerVázquez Nin, Gerardo.[Publisher-supplied data] The ovary is a suitable organ for studying the processes of cell death. Cell death was first described in the rabbit ovary (Graaffian follicles), the phenomenon being called chromatolysis. To date, it is recognized that various forms of cell death (programmed cell death, apoptosis and autophagy) are essential components of ovarian development and function. Programmed cell death is responsable for the ovarian endowment of primordial follicles around birth; in the prepuberal and adult period, apoptosis is a basic mechanism by which oocytes are eliminated by cancer therapies and environmental toxicants; in the ovarian cycle, follicular atresia and luteal regression involve follicular cell apoptosis. Finally, abnormalities in cell death processes may lead to ovarian disease such as cancer and chemoresistance. In this book, after an introductory description of various forms of cell death and of the ovary development and function in mammals, the processes of cell death in ovarian somatic cells and oocytes are described at cytological, physiological and molecular levels and analyzed in the embryonic, prepuberal and adult ovary. A complex array of molecular pathways triggered by extrinsic and intrinsic signals able tor induce or suppress cell death in the same cell, according to cell type and ovary developmental stage, emerges. Physiological interactions with the axis hypothalamus-hypophysis as well as ovarian internal functional signal are also critically reviewed to explain the abortive development of follicles before the beginning of the ovarian cycle. The book conveys information useful to the updating of biologists and physicians who are interested to the ovary biology and functions. Hopefully it should provide also clues for stimulating novel experiments in the study of cell death in the mammalian ovary still at an early stage.
- 2014 SpringerWu, Hao.Beginning from centuries of anecdotal descriptions of cell death, such as those on the development of the midwife toad in 1842 by Carl Vogt, to modern-day investigations of cell death as a biological discipline, it has become accepted that cell death in multicellular organisms is a normal part of life. This book provides a comprehensive view of cell death, from its mechanisms of initiation and execution, to its implication in human disease and therapy. Physiological cell death plays critical roles in almost all aspects of biology, and the book details its roles in lymphocyte homeostasis, neuronal function, metabolism, and the DNA damage response.?When physiological cell death goes awry, diseases can arise, and cancer is presented as a central paradigm for the consequences of derangements in the interplay between cell survival and cell death. At the same time, the potential promise of targeted therapies aimed at interdicting cell death machineries are also discussed extensively. The molecular mechanisms that underlie apoptotic cell death are illustrated from the perspectives of both the intrinsic, mitochondrial apoptotic pathway and the extrinsic, death receptor pathway. Key players in these pathways, such as the Bcl2 family proteins, cytochrome c, Apaf-1, caspases, death receptor adapter proteins, and inhibitor of apoptosis proteins, are presented from both functional and structural angles. Until only a few years ago, programmed cell death has been considered essentially synonymous with apoptosis. However, we now know that programmed cell death can also take other forms such as necrosis or necroptosis, and to this end, the mechanisms that underlie programmed necrosis in development and host defense are illustrated. The past twenty plus years have seen an incredible growth of research in cell death, with one breakthrough after another, and the legacy still goes on with constant new surprises and findings. Long live cell death!
- 2013 SpringerJohnson, Daniel Eric.Defects in cell death pathways promote tumor development and progression, with potentially devastating consequences for cancer patients. Greater understanding of the defects occurring in cancer cells, and the unique characteristics of tumors which can make them vulnerable to cell death stimuli, offers tremendous opportunities for developing novel and effective anti-cancer therapies. In Cell Death in Cancer Biology and Treatment leading experts in the field provide a wealth of up-to-date knowledge regarding the molecular mechanisms and cell biological processes that control cell death. Each chapter also highlights recent advances in the translation of basic research findings into clinical trials. Beginning and established investigators alike will benefit from the thorough presentations of the most promising avenues for future development of cell death-based, anti-cancer strategies and agents. The volume begins with a detailed description of many of the cell death defects that have been identified in human tumor specimens. The unique bioenergetics of cancer cells, and the influence of the tumor microenvironment, autophagy, and cellular microRNAs on cancer cell death are then discussed, along with current progress in targeting these distinctive features and processes. Additional chapters describe recent advances, and the therapeutic benefits of targeting DNA repair pathways, protein chaperones, sphingolipid signaling, Bcl-2 family members, IAPs, death receptor signaling, the proteasome, and survival signaling emanating from the PI3K/AKT and RAS/RAF/MEK/ERK pathways. Finally, recent discoveries are presented regarding interactions between the immune system and dying cancer cells and the potential for optimizing these interactions to maximize anti-cancer activities. In summary, Cell Death in Cancer Biology and Treatment will be a valuable resource for scientists interested in cutting-edge understanding of aberrant cell death in cancer cells, and the multitude of innovative molecular targeting approaches that are actively being pursued to achieve selective activation of cell death in human malignancies.
- 2011 SpringerDittmar, Thomas; Zänker, Kurt S.1. Introduction / Thomas Dittmar and Kurt S. Zänker -- 2. Heterochronic control of AFF-1-mediated cell-to-cell fusion in C. elegans / Lilach Friedlander-Shani and Benjamin Podbilewicz -- 3. Role of SNAREs in membrane fusion / Bhanu P. Jena -- 4. Molecular and cellular mechanisms of mammalian cell fusion / Xiaofeng Zhou and Jeffrey L. Platt -- 5. Membrane fusions during mammalian fertilization / Bart M. Gadella and Janice P. Evans -- 6. Trophoblast fusion / Berthold Huppertz and Martin Gauster -- 7. Macrophage fusion and multinucleated giant cells of inflammation / Amy K. McNally and James M. Anderson -- 8. Molecular mechanisms of myoblast fusion across species / Adriana Simionescu and Grace K. Pavlath -- 9. Cell-fusion-mediated reprogramming : pluripotency or transdifferentiation? : implications for regenerative medicine / Daniela Sanges, Frederic Lluis, and Maria Pia Cosma -- 10. Cell fusion and tissue regeneration / Manuel Álvarez-Dolado and Magdalena Martínez-Losa -- 11. Dendritic cell-tumour cell fusion vaccines / Walter T. Lee.
- 2011 SpringerDittmar, Thomas; Zänker, Kurt S.Introduction / Thomas Dittmar and Kurt S. Zänker -- Horizontal Gene Transfers with or without Cell Fusions in All Categories of the Living Matter / Joseph G. Sinkovics -- Class III Viral Membrane Fusion Proteins / Marija Backovic and Theodore S. Jardetzky -- Human Trophoblast in Trisomy 21: A Model for Cell - Cell Fusion Dynamic Investigation / André Malassiné, Guillaume Pidoux, Pascale Gerbaud, Jean Louis Frendo and Danièle Evain-Brion -- Cell Fusion and Hyperactive Osteoclastogenesis in Multiple Myeloma / Franco Silvestris, Sabino Ciavarella, Sabino Strippoli and Franco Dammacco -- Cell Fusion Hypothesis of the Cancer Stem Cell / Xin Lu and Yibin Kang -- Expression of Macrophage Antigens by Tumor Cells / Ivan Shabo and Joar Svanvik -- Leukocyte-Cancer Cell Fusion: Initiator of the Warburg Effect in Malignancy? / Rossitza Lazova, Ashok Chakraborty and John M. Pawelek -- Cell Fusion, Drug Resistance and Recurrence CSCs / Christa Nagler, Kurt S. Zänker and Thomas Dittmar -- The Role of Microvesicles in Malignancies / Erna Pap.
- 2015 Springer ProtocolsPfannkuche, Kurt.This volume details protocols on detection and analysis of fusion events in various cell types in vitro and in vivo. Additional, protocols aim to facilitate the future highly relevant process of engineering cells for specific purposes, such as generation of transgenic embryos and development of hybrid cells, in order to tackle specific tasks in cell biology and medicine. Written for the Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and authoritative, Cell Fusion: Overviews and Methods, Second Edition serves as an ideal reference on cell fusion and laboratory protocols.
- 2008 Springer ProtocolsChen, Elizabeth H.Pt. 1. Cell fusion -- 1. Yeast mating, a model system for studying cell and nuclear fusion / Casey A. Ydenberg, Mark D. Rose -- 2. Cell fusion in the filamentous fungus, neurospora crassa / André Flei€ner, Anna R. Simonin, N. Louise Glass -- 3. Gametic cell adhesion and fusion in the uicellular alga chlamydomonas / Nedra F. Wilson -- 4. Cell Fusion in caenorhabditis elegans / Scott Alper, Benjamin Podbilewicz -- 5. Myoblast fusion in drosophila / Susan M. Abmayr, Shufei Zhuang, and Erika R. Geisbrecht -- 6. Mammalian fertilization is dependent on multiple membrane fusion events / Paul M. Wassarman, Eveline S. Litscher -- 7. Molecular control of mammalian myoblast fusion / Katie M. Jansen, Grace K. Pavlath -- 8. Placenta trophoblast fusion / Berthold Huppertz, Marcus Borges -- 9. Macrophage fusion / Agnès Vignery -- Pt. 2. Cell fusion assays -- 10. Cell fusion assays for yeast mating pairs / Eric Grote -- 11. Ultrastructural analysis of cell fusion in yeast / Alison E. Gammie -- 12. Isolation and in vitro binding of mating type plus fertilization tubules from chlamydomonas / Nedra F. Wilson -- 13. Optical imaging of cell fusion and fusion proteins in caenorhabditis elegans / Star Ems, William A. Mohler -- 14. Ultrastructural imaging of cell fusion in caenorhabditis elegans / Star Ems, William A. Mohler -- 15. Live imaging of drosophila myoblast fusion / Brian E. Richardson, Karen Beckett, Mary K. Baylies -- 16. Ultrastructural Analysis of myoblast fusion in drosophila / Shiliang Zhang, Elizabeth H. Chen -- 17. Genomic approach to myoblast fusion in drosophila / Beatriz Estrada, Alan M. Michelson -- 18. Mesenchymal cell fusion in the sea urchin embryo / Paul G. Hodor, Charles A. Ettensohn -- 19. Sperm-egg fusion assay in mammals / Naokazu Inoue, Masaru Okabe -- 20. Quantitative assays for cell fusion / Jessica H. Shinn-Thomas, Victoria L. Scranton, William A. Mohler -- 21. Fusion assays and models for the trophoblast / Sascha Drewlo, ... [et al.] -- 22. Methods to fuse macrophages in vitro / Agnès Vignery.
- 2011 SpringerLarsson, Lars-Inge.
- 2005 Springer ProtocolsMossman, Brooke T.; Taatjes, Douglas J.Molecular beacons: fluorescent probes for detection of endogenous mRNAs in living cells -- Second-harmonic imaging of collagen -- Visualizing calcium signaling in cells by digitized wide-field and confocal fluorescent microscopy -- Multifluorescence labeling techniques and confocal laser scanning microscopy on lung tissue -- Evaluation of confocal microscopy system performance -- Quantitative analysis of atherosclerotic lesion composition in mice -- Applications of microscopy to genetic therapy of cystic fibrosis and other human diseases -- Laser scanning cytometry: principles and applications -- Near-clinical applications of laser scanning cytometry -- Laser capture microdissection -- Analysis of asbestos-induced gene expression changes in bronchiolar epithelial cells using laser capture microdissection and quantitative reverse transriptase-polymerase chain reaction -- New approaches to fluorescence in situ hybridization -- Microarray image scanning -- Near-field scanning optical microscopy in cell biology and cytogenetics -- Porosome: the fusion pore revealed by multiple imaging modalities -- Secretory vesicle swelling by atomic force microscopy -- Imaging and probing cell mechanical properties with the atomic force microscopy -- Reflection contrast microscopy: the bridge between light and electron microscopy -- Three-dimensional analysis of single particles by electron microscopy: sample preparation and data acquisition -- Three-dimensional reconstruction of single particles in electron microscopy: image processing -- A new microbiopsy system enables rapid preparation of tissue for high-pressure freezing.
- 2007 ScienceDirectDischer, Dennis E.; Wang, Yu-Li.Also available: Print – 2007
- 2011 Springer ProtocolsParsons, Maddy; Wells, Claire M.Cell migration : an overview / Miguel Vicente-Manzanares and Alan Rick Horwitz -- Scratch-wound assay / Giles Cory -- HGF-induced DU145 cell scatter assay / Sally T. Fram, Claire M. Wells, and Gareth E. Jones -- Using the dunn chemotaxis chamber to analyze primary cell migration in real time / Sanjay Chaubey, Anne J. Ridley, and Claire M. Wells -- Imaging cells within 3D cell-derived matrix / Samantha J. King and Maddy Parsons -- Live cell imaging of neuronal growth cone motility and guidance in vitro / Daniel M. Suter -- Boyden chamber / Marco Falasca, Claudio Raimondi, and Tania Maffucci -- Transwell® invasion assays / John Marshall -- Imaging podosome dynamics and matrix degradation / Taylor W. Starnes, Christa L. Cortesio, and Anna Huttenlocher -- Endothelial cell migration under flow / Beata Wojciak-Stothard -- In vitro analysis of chemotactic leukocyte migration in 3D environments / Michael Sixt and Tim Lammermann -- Quantification of transendothelial migration using three-dimensional confocal microscopy / Robert J. Cain, Barbara Borda d'Agua, and Anne J. Ridley -- Chemotaxis of slow migrating mammalian cells analysed by video microscopy / Roman Zantl and Elias Horn -- Live cell fluorescence microscopy techniques / Shawn A. Galdeen and Alison J. North -- Measuring invasion in an organotypic model / Veronika Jenei, Maria L. Nystrom, and Gareth J. Thomas -- Analysis of cell migration using Caenorhabditis elegans as a model system / Ming-Ching Wong, Maria Martynovsky, and Jean E. Schwarzbauer -- Drosophila hemocyte migration : an in vivo assay for directional cell migration / Carolina G.A. Moreira [and others] -- Measuring inflammatory cell migration in the zebrafish / Philip M. Elks, Catherine A. Loynes, and Stephen A. Renshaw -- Border cell migration : a model system for live imaging and genetic analysis of collective cell movement / Mohit Prasad [and others] -- Assessment of development and chemotaxis in Dictyostelium discoideum mutants / Yulia Artemenko, Kristen F. Swaney, and Peter N. Devreotes -- Simple experimental and spontaneous metastasis assays in mice / Gary M. Box and Suzanne A. Eccles -- Two-photon intravital multicolour imaging to study metastatic behaviour of cancer cells in vivo / Sylvia E. Le Devedec [and others] -- Measuring angiogenesis in mice / Bernardo Tavora [and others] -- Time-lapse imaging of chick cardiac precursor cells / Junfang Song, Qiaoyun Yue, and Andrea Munsterberg -- Characterizing system performance in total internal reflection fluorescence microscopy / Juliane P. Schwarz, Ireen Konig, and Kurt I. Anderson -- Fluorescence recovery after photobleaching / Alex Carisey [and others] -- Measuring FRET using time-resolved FLIM / Penny E. Morton and Maddy Parsons -- Cell migration in confinement : a micro-channel-based assay / Melina L. Heuze [and others] -- Functional screening with a live cell imaging-based random cell migration assay / Wies van Roosmalen [and others] -- Beads on the run : beads as alternative tools for chemotaxis assays / Eric Theveneau and Roberto Mayor.
- 2010 KargerEntschladen, Frank; Zänker, Kurt S.The migrating cell / Entschladen, F., Zänker, K.S. -- Stem cell migration in health and disease / Dittmar, T. ... [et al.] -- Leukocyte motility and human disease / Cooper, K., Nuzzi, P., Huttenlocher, A. -- Coordination of leukocyte polarity and migration / Martín-Cófreces, N.B., Serrador, J.M., Sánchez-Madrid, F. -- Positioning phosphoinositide 3-kinase in chemokine and antigen-dependent T-lymphocyte navigation mechanisms / Ward, S.G. -- Migration of functionally specialized T-helper cells : TFH cells, Th17 cells, and FoxP3+ T cells / Kim, C.H. -- ADAMs and ectodomain proteolytic shedding in leukocyte and tumour cell migration / Ager, A., Knäuper, V., Poghosyan, Z. -- Guided tour of cell migration : signals and pathways / Ratke, J., Lang, K. -- Regulation of the E-cadherin adhesion complex in tumor cell migration and invasion / Menke, A., Giehl, K. -- The cytoskeletal connection : understanding adaptor proteins / Ziegler, W.H. -- Locomotor force generation by myosins / Jbireal, J.M.A., Entschladen, F., Zänker, K.S.
- 2006 SpringerWells, Alan.Cancer Morbidity and mortality result from invasive and metastatic spread. Advances in the field have highlighted the central role of cell motility during the dynamic and transient process of tumor invasion and metastasis. This book presents an overview of these studies.
- 2012 ScienceDirectSperelakis, Nick.Sect. I. Biophysical chemistry, metabolism, second messengers, and ultrastructure. Biophysical chemistry of physiological solutions / Jeffrey c. Freedman -- Physiological structure and function of proteins / Matthew R. Pincus -- Cell membranes / Jeffrey C. Freedman -- Ionophores in planar lipid bilayers / Jeffrey C. Freedman -- Cell structure / Michael S. Forbes -- Signal transduction and second messengers / Aldebaran M. Hofer -- Calcium as an intracellular second messenger: mediation by calcium-binding proteins / John R. Dedman and Marcia A. Kaetzel -- Sect. II. Membrane potential, transport physiology, pumps, and exchangers. Diffusion and permeability / Nicholas Sperelakis and Jeffrey C. Freedman -- Origin of resting membrane potentials / Nicholas Sperelakis -- Gibbs-Donnan equilibrium potentials / Nicholas Sperelakis -- Mechanisms of carrier-mediated transport: facilitated diffusion, cotransport and countertransport / Steven M. Grassl -- Active ion transport by ATP-driven ion pumps / Robert A. Farley -- Ca2+ -ATPases / Tracy J. Pritchard, Istvan Edes and Evangelia G. Kranias -- Na+ -Ca2+ exchange currents / John H.B. Bridge, Natalia S. Torres and Michela Ottolia -- Intracellular chloride regulation / Francisco J. Alvarez-Leefmans -- Osmosis and regulation of cell volume / Clive M. Baumgarten and Joseph J. Feher -- Intracellular pH regulation / Robert W. Putnam -- Sect. III. Membrane excitability and ion channels. Cable properties and propagation of action potentials / Nicholas sperelakis -- Electrogenesis of membrane excitability / Nicholas Sperelakis -- Patch-clamp techniques / Laura Conforti -- Structure and mechanism of voltage-gated ion channels / Simon Rock Levinson and William A. Sather -- Biology of gap junctions / Richard D. Veenstra -- Regulation of cardiac ion channels by cyclic nucleotide-dependent phosphorylation / Gordon M. Wahler and Nicholas Sperelakis -- Direct regulation of ion channels by GTP-binding proteins / Atsushi Inanobe and Yoshihisa Kurachi -- Developmental changes in ion channels / Takeshi Kobayashi ... [et al.] -- Regulation of ion channel localization and activity through interactions with the cytoskeleton / Stephen Lambert -- Why are so many ion channels mechanosensitives? / Catherine E. Morris -- Sect. IV. Ion channels as targets for toxins, drugs, and genetic diseases. Ion channels as targets for toxins / Kenneth M. Blumenthal -- Ion channels as targets for drugs / Seth Robey, Kevin J. Sampson and Robert S. Kass -- Inherited diseases of ion transport / Robert A. Farley -- Sect. V. Synaptic transmission and sensory transduction. Ligand-gated ion channels / Kenneth R. Tovar and Gary L. Westbrook -- Synaptic transmission / Janusz B. Suszkiw -- Excitation-secretion coupling / Nicole Gallo-Payet and Marcel Daniel Payet -- Stimulus-response coupling in metabolic sensor cells / Stan Misler -- Cyclic nucleotide-gated ion channels / Anita L. Zimmerman -- Sensory receptors and mechanotransduction / Andrew S. French and Päivi H. Torkkeli -- Acoustic transduction / Daniel C. Marcus -- Visual transduction / Anita L. Zimmerman -- Gustatory and olfactory sensory transduction / Stephen D. Roper -- Infrared sensory organs / Stephen D. Roper and Michael S. Grace -- Electroreceptors and magnetoreceptors / Timothy C. Tricas and Bruce A. Carlson -- Sect. VI. Muscle and other contractile systems. Skeletal muscle excitability / Nicholas Sperelakis, Judith Heiny and Hugo gonzalez-Serratos -- Cardiac action potentials / Gordon M. Wahler -- Smooth muscle excitability / Neil D. Detweiler ... [et al.] -- Excitation-contraction coupling in skeletal muscle / Judith A. Heiny and Gerhard Meissner -- Contraction of muscles: mechanochemistry / Richard J. Paul -- Flagella, cilia, actin- and centrin-based movement / Kenneth W. Foster -- Electrocytes of electric fish / Anthony L. Gotter, Marcia A. Kaetzel and John R. Dedman -- Sect. VII. Protozoa and bacteria. Physiological adaptations of protists / Michael Levandowsky -- Physiology of prokaryotic cells / Dennis W. Grogan -- Sect. VIII. Specialized processes: photosynthesis and bioluminescence. Photosynthesis / Darrell Fleischman -- bioluminescence / J. Woodland Hastings.
- 2013 Springer ProtocolsGalluzzi, Lorenzo.Cell senescence as both a dynamic and a static phenotype / Andrew R.J. Young, Masako Narita, and Masashi Narita -- Senescence regulation by mTOR / Vjekoslav Dulic -- Senescence regulation by the p53 protein family / Yingjuan Qian and Xinbin Chen -- Markers of cellular senescence / Amancio Carnero -- Biomarkers of cell senescence assessed by imaging cytometry / Hong Zhao and Zbigniew Darzynkiewicz -- Cytofluorometric assessment of cell cycle progression / Ilio Vitale, Mohamed Jemaà, Lorenzo Galluzzi, Didier Metivier, Maria Castedo, and Guido Kroemer -- Quantification of cell cycle-arresting proteins / Oliver Kepp, Isabelle Martins, Laurie Menger, Mickaël Michaud, Sandy Adjemian, Abdul Qader Sukkurwala, Lorenzo Galluzzi, and Guido Kroemer -- Colorimetric detection of senescence-associated [beta] galactosidase / Koji Itahana, Yoko Itahana, and Goberdhan P. Dimri -- Chemiluminescent detection of senescence-associated [beta] galactosidase / Vinicius Bassaneze, Ayumi Aurea Miyakawa, and José Eduardo Krieger -- Detection of the senescence-associated secretory phenotype (SASP) / Francis Rodier -- Unbiased characterization of the senescence-associated secretome using SILAC-based quantitative proteomics / Juan Carlos Acosta, Ambrosius P. Snijders, and Jesús Gil -- Detection of senescence-associated heterochromatin foci (SAHF) / Katherine M. Aird and Rugang Zhang -- Monitoring DNA damage during cell senescence / Glyn Nelson and Thomas von Zglinicki -- Assessment and quantification of telomerase enzyme activity / Michelle F. Maritz, Laura A. Richards, and Karen L. MacKenzie -- Methods for the assessment of telomere status / Asako J. Nakamura -- Detection of nuclear envelope alterations in senescence / Clea Bárcena, Fernando G. Osorio, and José Maria Pérez Freije -- Measuring reactive oxygen species in senescent cells / João F. Passos, Satomi Miwa, and Thomas von Zglinicki -- Quantification of protein carbonylation / Nancy B. Wehr and Rodney L. Levine -- Assays for the measurement of lipid peroxidation / Ana Cipak Gasparovic, Morana Jaganjac, Branka Mihaljevic, Suzana Borovic Sunjic, and Neven Zarkovic -- Raman spectroscopy for the detection of AGEs/ALEs / J. Renwick Beattie, John J. McGarvey, and Alan W. Stitt -- Monitoring oncogenic B-RAF-induced senescence in melanocytes / Sieu L. Tran and Helen Rizos -- Methods to investigate the role of SIRT1 in endothelial senescence / Bo Bai and Yu Wang -- Monitoring nutrient signaling through the longevity protein p66SHC1 / Sofia Chiatamone Ranieri and Giovambattista Pani -- Profiling the metabolic signature of senescence / Florian M. Geier, Silke Fuchs, Gabriel Valbuena, Armand M. Leroi, and Jacob G. Bundy -- Genome-wide RNAi screening to identify regulators of oncogene-induced cellular senescence / Narendra Wajapeyee, Sara K. Deibler, and Michael R. Green -- Integrated approach for monitoring cell senescence / Tatiana V. Pospelova, Zhanna V. Chitikova, and Valery A. Pospelov -- Robust multiparametric assessment of cellular senescence / Clara Correia-Melo, Diana Jurk, and João F. Passos -- Assessing chronological aging in bacteria / Stavros Gonidakis and Valter D. Longo -- Assessing organismal aging in the filamentous fungus Podospora anserina / Heinz D. Osiewacz, Andrea Hamann, and Sandra Zintel -- Assessing chronological aging in Saccharomyces cerevisiae / Jia Hu, Min Wei, Mario G. Mirisola, and Valter D. Longo -- Assessing aging and senescent decline in Caenorhabditis elegans : cohort survival analysis / Eirini Lionaki and Nektarios Tavernarakis -- High-throughput and longitudinal analysis of aging and senescent decline in Caenorhabditis elegans / Eirini Lionaki and Nektarios Tavernarakis -- Assessing senescence in Drosophila using video tracking / Reza Ardekani, Simon Tavaré, and John Tower -- Assessing vascular senescence in zebrafish / Sandra Donnini, Antonio Giachetti, and Marina Ziche.
- 2015 SpringerBrison, Daniel R.; Leese, Henry J.The book considers signaling events from the zygote embryo through to the blastocyst with relevant data from embryonic stem (ES) cells, including dialogue with the extracellular environment and with the maternal tract during the implantation process. Application of the knowledge described to improve the success of human and animal assisted conception is considered where appropriate, but the focus is largely on fundamental rather than applied cell/molecular biology, as this is the area that has historically been neglected. While the general features of metabolism during preimplantation development are well established, especially in terms of nutrient requirements, uptake and fate, remarkably little is known about early embryo signaling events, intracellular or intercellular, between individual embryos in vitro or with the female reproductive tract in vivo. This contrasts with the wealth of information on cell signaling in somatic cells and tissues, as a glance at any textbook of biochemistry illustrates. This lack of information is such that our understanding of the molecular cell biology of early embryos -- a prerequisite to defining the mechanisms which regulate development at this critical stage of the life cycle -- is seriously incomplete. This volume is the first to address this issue by describing the current state of knowledge on cell signaling during mammalian early embryo development and highlighting priority areas for research.
- 2005 SpringerBhattacharya, Jahar.Heme oxygenase-1 and carbon monoxide in vascular regulation / Stefan W. Ryter and Augustine M.K. Choi -- Tumor necrosis factor-[alpha]/receptor signaling through the Akt kinase / Osman Nidai Ozes ... [et al.] -- Protein modifications by nitric oxide and reactive nitrogen species / Harry Ischiropoulos -- Redox signaling in hypoxic pulmonary vasoconstriction / E. Kenneth Weir ... [et al.] -- cGMP-dependent protein kinase in regulation of the perinatal pulmonary circulation / Usha Raj ... [et al.] -- Glutamate receptor activation in the pathogenesis of acute leg injury / Sami I. Said -- Carboxyl methylation of small GTPases and endothelial cell function / Sharon Rounds, Elizabeth O. Harrington, and Qing Lu -- Pressure-induced inflammatory signaling in lung endothelial cells / Wolfgang M. Kuebler -- Regulation of endothelial barrier function: contributions of the transcellular and paracellular pathways / Dolly Mehta, Richard D. Minshall, and Asrar B. Malik -- Sphingolipid signaling: implications for vascular biology / Margaret M. Harnett -- Regulations of cytokine signaling / Bao Q. Vuong ... [et al.] -- Cell signaling by vasoactive agents / Barry L. Fanburg ... [et al.] -- Reactive oxygen species and cell signaling in lung ischemia / Aron B. Fisher -- Pulmonary vascular barrier regulation by thrombin and Edg receptors / Jeffrey R. Jacobson and Joe G.N. Garcia -- Second-messenger signaling in lung capillaries / Kaushik Parthasarathi -- Plasma membrane-to-nucleus calcium signaling / Giles E. Hardingham -- Signaling by mitochondria / Navdeep S. Chandel -- Pro-inflammatory signaling by endothelial focal complexes in lung / Sunita Bhattacharya -- Hydrogen peroxide as intracellular messenger: production, target, and elimination / Sue Goo Rhee ... [et al.] -- Calcium-inhibited adenylyl cyclase (AC6) controls endothelial cell barrier function / Troy Stevens.
- 2011 SpringerSako, Yasushi; Ueda, Masahiro.
- 2009 SpringerGee, Adrian P.Part 1. Regulatory. -- Regulation of Cell Product Manufacturing and Delivery: A United States Perspective / R.W. Lindblad -- The Regulatory Situation for Academic Cell Therapy Facilities in Europe / I. Slaper-Cortenbach, M. Scott, D. Herrmann, M. Introna and K. Theunissen, et al. -- A Regulatory System for Cell and Tissue Therapies: Proposed Approach in Australia / A. Farrugia -- Part 2. GMP Facility Design. -- University of Minnesota - Molecular and Cellular Therapeutics (MCT) / D.H. McKenna -- University of Pittsburgh Cancer Institute - Hematopoietic Stem Cell Laboratory (HSC Lab)/Immunological Monitoring and Cellular Products Laboratory (IMCPL) / D.L. Griffin, A.D. Donnenberg and T.L. Whiteside / Baylor College of Medicine - Center for Cell and Gene Therapy (CAGT) / A. Gee -- Design of a New GMP Facility - Lessons Learned / A. Gee -- Part 3. Professional Cell Therapy Standards. -- AABB Cell Therapy Standards / Z.M. Szczepiorkowski and E. Nunes -- Professional Standards for Cellular Therapies: Foundation for the Accreditation of Cellular Therapy (FACT) / P.I. Warkentin -- Part 4. Facility Operations -- Standard Operating Procedures / C.G. Lindgren -- Staffing, Training, and Competency / D.M. Kadidlo -- Cleaning Procedures / A. Gee and D.L. Lyon -- Environmental Monitoring / A. Gee and D.L. Lyon -- Supply Management / A. Gee and C.M. Rooney -- Facility Equipment / D.L. Griffin -- Quality / J.W. Atkins -- Product Manufacturing / A. Gee -- Product Review, Release, and Administration / N.H. Collins -- Use of a Facility Master File to Facilitate Regulatory Submissions for Cell Therapy Products / E.J. Read and H.M. Khuu.
- 2006 SpringerSanberg, Cyndy Davis; Sanberg, Paul R.Current views of the embryonic and neural stem cell : cell replacement or molecular repair? / Roya Sabetrasekh ... [et al.] -- Developing novel cell sources for transplantation in Parkinson's disease / Nicolaj S. Christophersen ... [et al.] -- Neural transplantation in the nonhuman primate model of Parkinson's disease / Kimberly B. Bjugstad and John R. Sladek, Jr. -- Cell-based therapy for Huntington's disease / Claire M. Kelly, Stephen B. Dunnett, and Anne E. Rosser -- Use of bone marrow stem cells as therapy for behavioral deficits in rodent models of Huntington's disease / Gary L. Dunbar, Justin D. Oh-Lee, and Laurent Lescaudron -- Human neuroteratocarcinoma cells as a neural progenitor graft source for cell transplantation in stroke / Cesario V. Borlongan ... [et al.] -- Therapeutic applications of bone marrow-derived stem cells in neurologic injury and disease / C. Dirk Keene ... [et al.] -- Cell therapy for models of pain and traumatic brain injury / Mary Eaton and Jacqueline Sagen -- The use of sertoli cells in neural transplantation / Dwaine F. Emerich, Cesario V. Borlongan, and Craig Halberstadt -- The choroids plexus : a novel graft source for neural transplantation / Cesario V. Borlongan ... [et al.] -- Progress and challenges in immunoisolation for CNS cell therapy / Christopher G. Thanos and Dwaine F. Emerich -- Evidence-based methodology for advancing neural reconstruction / Stephen Polgar -- Hematopoietic cell therapy for brain repair / Martina Vendrame and Alison E. Willing -- Stem cells and regenerative medicine : commercial and pharmaceutical implications / L. Eduardo Cruz and Silvia P. Azevedo.
- 2013 SpringerJolkkonen, Jukka; Walczak, Piotr.Stroke remains one of the main causes of death and disability worldwide. Effective therapy for stroke recovery remains an unmet need. Much hope and promises are placed on cell-based therapies. The aim of this book is to provide focused yet comprehensive reviews on the current state of cell-based approaches in the treatment of stroke. The topics covered include experimental data on functional outcome after intravascular and intracerebral delivery of cells in stroke animals, followed by translational chapters which will rely heavily on the use of different imaging modalities in the tracking of cells. The last and most challenging part will describe the early phase of clinical studies, providing guidelines for future research and clinical applications. Clearly and concisely written, this text will be a useful resource for neurologists, radiologists, and neuroscientists interested in cell transplantation as a therapeutic strategy for stroke patients.
- 2014 KargerCasaroli-Marano, Ricardo Pedro; Zarbin, Marco A.Age-related macular degeneration: clinical findings, histopathology, and imaging techniques / Zarbin, M.A.; Casaroli-Marano, R.P.; Rosenfeld, P.J. -- General pathophysiology in retinal degeneration / Wert, K.J.; Lin, J.H.; Tsang, S.H. -- Juvenile-onset macular degeneration and allied disorders / North, V.; Gelman, R.; Tsang, S.H. -- Diagnosis and complementary examinations / Menghini, M.; Duncan, J.L. -- Stem cells for retinal repair / Stern, J.; Temple, S. -- Differentiation of pluripotent stem cells into retinal pigmented epithelium / Croze, R.H.; Clegg, D.O. -- Neural retinal regeneration with pluripotent stem cells / Ramsden, C.M.; Powner, M.B.; Carr, A.-J.F.; Smart, M.J.K.; da Cruz, L.; Coffey, P.J. -- Stem cells, retinal ganglion cells and glaucoma / Sluch, V.M.; Zack, D.J. -- Stem cells : immunology and immunomodulation / Tena, A.; Sachs, D.H. -- Biochemical restoration of aged human Bruch's membrane : experimental studies to improve retinal pigment epithelium transplant survival and differentiation / Sugino, I.K.; Sun, Q.; Cheewatrakoolpong, N.; Malcuit, C.; Zarbin, M.A. -- Approaches to cell delivery : substrates and scaffolds for cell therapy / Kundu, J.; Michaelson, A.; Baranov, P.; Young, M.J.; Carrier, R.L. -- Microdevice-based cell therapy for age-related macular degeneration / Lu, B.; Tai, Y.-C.; Humayun, M.S. -- Cell and gene therapy / Rao, R.C.; Zacks, D.N. -- Cellular manufacturing for clinical applications / Sheu, J.; Klassen, H.; Bauer, G. -- Regulatory issues in cell-based therapy for clinical purposes / Casaroli-Marano, R.P.; Tabera, J.; Vilarrodona, A.; Trias, E.
- 2006. SpringerBaluška, F.; Barlow, Peter W.; Volkmann, Dieter.Cell-cell channels and their implications for cell theory / Frantisek Baluska, Dieter Volkmann, and Peter W. Barlow -- Mating cell-cell channels in conjugating bacteria / Elisabeth Grohmann -- The tetrahymena conjugation junction / Eric S. Cole -- Cytoplasmic bridges in volvox and its relatives / Harold J. Hoops, Ichiro Nishii, and David L. Kirk -- Vegetative hyphal fusion in filamentous fungi / Nick D. Read and M. Gabriela Roca -- Plasmodesmata: cell-cell channels in plants / Yoselin Benitez Alfonso, Laurence Cantrill, and David Jackson -- Sieve-pore plugging mechanisms / Aart J.E. van Bel -- Actin and myosin VIII in plant cell-cell channels / Jozef Samaj ... [et al.] -- Cell-cell communication in wood / John R. Barnett -- TMV movement protein targets cell-cell channels in plants and prokaryotes: possible roles of tubulin- and FtsZ-based cytoskeletons / Manfred Heinlein -- Viral movement proteins induce tubule formation in plant and insect cells / Jan W.M. van Lent and Corinne Schmitt-Keichinger -- Cell-cell movements of transcription factors in plants / Alexis Maizel -- Gap junctions: cell-cell channels in animals / Fabio Mammano -- Tunneling nanotubes: membranous channels between animal cells / Hans-Hermann Gerdes and Amin Rustom -- Cytoplasmic bridges as cell-cell channels of germ cells / Sami Ventelä -- Fusome as a cell-cell communication channel of drosophila ovarian cyst / Jean-René Huynh -- Cytonemes as cell-cell channels in human blood cells / Svetlana Ivanovna Galkina .. [et al.] -- Paracellular pores in endothelial barriers / Luca Manzi and Gianfranco Bazzoni -- Channels across endothelial cells / Radu V. Stan -- Molecular transfers through transient lymphoid cell-cell channels / Mary Poupot, Julie Gertner, and Jean-Jacques Fournié -- Cell-cell transport of homeoproteins: with or without channels / Alain Joliot and Alain Prochiantz -- Virological synapse for cell-cell spread of viruses / Eduardo Garcia and Vincent Piguet -- Cell-cell fusion: transient channels leading to plasma membrane merger / William A. Mohler.
- 2013 Springer ProtocolsBaudino, Troy A.Proteomics analysis of contact-initiated eph receptor-ephrin signaling / Claus Jorgensen and Alexei Poliakov -- Control of vascular tube morphogenesis and maturation in 3D extracellular matrices by endothelial cells and pericytes / George E. Davis ... [and 8 others] -- Analyzing cell-cell interactions in 3-dimensional adhesion assays / Stephanie L.K. Bowers and Troy A. Baudino -- Production of spontaneously beating neonatal rat heart tissue for calcium and contractile studies / Fnu Gerilechaogetu ... [and 6 others] -- Paracrine communication between mechanically stretched myocytes and fibroblasts / Hao Feng ... [and 6 others] -- Assessing blood-brain barrier function using in vitro assays / Joseph Bressler, Katherine Clark, and Cliona O'Driscoll -- Methods to assess tissue permeability / Juan C. Ibla and Joseph Khoury -- In vivo quantification of metastatic tumor cell adhesion in the pulmonary microvasculature / F. Bartsch ... [and 4 others] -- Cell membrane vesicles as a tool for the study of direct epithelial-stromal interaction: lessons from CD147 / Eric Gabison ... [and 3 others] -- Microencapsulation of stem cells to study cellular interactions / Keith Moore, Adam Vandergriff, and Jay D. Potts -- Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies / Timothy N. Feinstein -- Single cell analysis of lipid rafts / William T. Lee -- Micropatterning cell adhesion on polyacrylamide hydrogels / Jian Zhang ... [and 3 others] -- Measuring cell-cell tugging forces using bowtie-patterned mPADs (microarray post detectors) / Daniel M. Cohen, Mike T. Yang, and Christopher S. Chen -- Generation and analysis of biosensors to measure mechanical forces within cells / Katharina Austen ... [and 4 others] -- Proteomic analysis of the left ventricle post-myocardial infarction to identify in vivo candidate matrix metalloproteinase substrates / Andriy Yabluchanskiy ... [and 5 others].
- 2005 SpringerCopani, Agata; Nicoletti, F.Cell cycle activation in neurons: the final exit of brain-morpho-dysregulation / Thomas Arendt -- Paved with good intentions: the link between cell cycle and cell death in the mammalian central nervous system / Yan Yang and Karl Herrup -- The role of presenilins in the cell cycle and apoptosis / Mervyn J. Monteiro -- Cell cycle activation and cell death in the nervous system / Zsuzsanna Nagy -- Cell cycle and chromosome segregation defects in Alzheimer's disease / Huntington Potter -- Alzheimer disease-a new beginning or a final exit? / Mark E. Obrenovich ... [et al.] -- From cell cycle activation to the inhibition of the WNT pathway: a hypothesis of how neurons die in response to B-Amyloid / Agata Copani ... [et al.].
- 2010 SpringerPozzi, Ambra; Zent, Roy.
- 2015 Springer ProtocolsLangel, Ülo.Classes of cell-penetrating peptides / Margus Pooga and Ülo Langel -- Penetratin story : an overview / Edmond Dupont, Alain Prochiantz, and Alain Joliot -- Prediction of cell-penetrating peptides / Mattias Hällbrink and Mati Karelson -- Computer-aided virtual screening and designing of cell- penetrating peptides / Ankur Gautam, Kumardeep Chaudhary, Rahul Kumar, and Gajendra Pal Singh Raghava -- Investigating membrane interactions and structures of CPPs / Fatemeh Madani and Astrid Gräslund -- Determining the effects of membrane-interacting peptides on membrane integrity / William C. Wimley -- Study of CPP mechanisms by mass spectrometry / Sandrine Sagan, Chérine Bechara, and Fabienne Burlina -- Methods to study the role of the glycocalyx in the uptake of cell-penetrating peptides / Samuel Schmidt, Rike Wallbrecher, Toin H. van Kuppevelt, and Roland Brock -- Toxicity, immunogenicity, uptake, and kinetics methods for CPPs / Julia Uusna, Kent Langel, and Ülo Langel -- Unraveling the mechanisms of peptide-mediated delivery of nucleic acids using electron microscopy / Helerin Margus, Carmen Juks, and Margus Pooga -- SCARA involvement in the uptake of nanoparticles formed by cell-penetrating peptides / Henrik Helmfors, Staffan Lindberg, and Ülo Langel -- Protein mimicry and the design of bioactive Cell- penetrating peptides / John Howl and Sarah Jones -- Pepducins and other lipidated peptides as mechanistic probes and therapeutics / Ping Zhang, Lidija Covic, and Athan Kuliopulos -- Identification and characterization of homing peptides using in vivo peptide phage display / Maija Hyvönen and Pirjo Laakkonen -- Antimicrobial and antiviral applications of cell- penetrating peptides / Kalle Pärn, Elo Eriste, and Ülo Langel -- Visualizing actin architectures in cells incubated with cell-penetrating peptides / Lin He, Peter D. Watson, and Arwyn T. Jones -- Cell-penetrating peptides as carriers for transepithelial drug delivery in vitro / Stine Rønholt, Mie Kristensen, and Hanne Mørck Nielsen -- Pathway toward tumor cell-selective CPPs? / Isabel D. Alves, Manon Carré, and Solange Lavielle -- PepFects and nickFects for the intracellular delivery of nucleic acids / Piret Arukuusk, Ly Pärnaste, Mattias Hällbrink, and Ülo Langel -- In vitro assays to assess exon skipping in duchenne muscular dystrophy / Prisca Boisguerin, Liz O'Donovan, Michael J. Gait, and Bernard Lebleu -- Applications of ApoB LDLR-binding domain approach for the development of CNS-penetrating peptides for alzheimer's disease / Eliezer Masliah and Brian Spencer -- CPP-based delivery system for in vivo gene delivery / Kaido Kurrikoff, Kadi-Liis Veiman, and Ülo Langel -- Application of CPPs for brain delivery / Artita Srimanee, Jakob Regberg, and Ülo Langel -- Intracellular delivery of nanoparticles with cell penetrating peptides / Giuseppina Salzano and Vladimir P. Torchilin -- Multifunctional oligoaminoamides for the receptor-specific delivery of therapeutic RNA / Judith Weber, Ulrich Lächelt, and Ernst Wagner -- Cell penetrating peptides for chemical biological studies / Ikuhiko Nakase, Toshihide Takeuchi, and Shiroh Futaki -- Experiences with CPP-based self assembling peptide systems for topical delivery of botulinum toxin / Jane Lee, Phil Kennedy, and Jacob M. Waugh -- Applications of CPPs in genome modulation of plants / Alicja Ziemienowicz, Jordan Pepper, and François Eudes -- DNA transfer into animal cells using stearylated CPP based Transfection Reagent / Kristiina Karro, Tiiu Männik, Andres Männik, and Mart Ustav -- Live cell genomics : cell-specific transcriptome capture in live tissues and cells / Thomas J. Bell and James Eberwine -- Live cell genomics : RNA exon-specific RNA-binding protein isolation / Thomas J. Bell and James Eberwine.
- Cells and tissues by light and electron microscopy : Microscopie photonique et électronique de tissus et de cellulesv. 2, 1970.Sandborn, Edmund B.
- 2014 SpringerHippenmeyer, Simon; Nguyen, Laurent.Cellular and Molecular Control of Neuronal Migration provides an up-to-date collection of reviews on the molecular and cellular principles of neuronal migration in the mammalian brain. Over the last decades a rich catalogue of signaling molecules controlling neuronal migration has been compiled, and within this book an international panel of experts provides up-to-date discussions of the state of knowledge how these distinct signaling pathways regulate various aspects of neuronal migration. This book introduces the reader to the latest discoveries and concepts of neuronal migration enabled through the application of most sophisticated methods and cutting edge experimental approaches. Cellular and Molecular Control of Neuronal Migration also provides an update on the underlying cellular and molecular basis of neurodevelopmental migration disorders in human patients for all interested neuroscientists and clinicians.Also available: Print – 2014
- 2013 Springer ProtocolsElbayoumi, Tamer; Olsen, Mark; Weissig, Volkmar.Nanoparticle-GFP "chemical nose" sensor for cancer cell identification / Daniel F. Moyano and Vincent M. Rotello -- Method to map spatiotemporal pH changes in a multicellular living organism using a DNA nanosensor / Sunaina Surana and Yamuna Krishnan -- Simple method to visualize and assess the integrity of lysosomal membrane in mammalian cells using a fluorescent dye / Syed K. Sohaebuddin and Liping Tang -- Gold nanoparticle as a marker for precise localization of nano-objects within intracellular sub-domains / Valeriy Lukyanenko and Vadim Salnikov -- Immunoisolation of nanoparticles containing endocytic vesicles for drug quantitation / Ari Nowacek [and others] -- Methods for isolation and identification of nanoparticle-containing subcellular compartments / Ari Nowacek [and others] -- Permeabilization of cell membrane for delivery of nano-objects to cellular sub-domains / Valeriy Lukyanenko -- Method to encapsulate molecular cargo within DNA Icosahedra / Dhiraj Bhatia [and others] -- Delivery of plasmid DNA to mammalian cells using polymer-gold nanorod assemblies / James Ramos, Huang-Chiao Huang, and Kaushal Rege -- Lipophilic-formulated gold porphyrin nanoparticles for chemotherapy / Puiyan Lee and Kenneth K.Y. Wong -- Mitochondria-specific nano-emulsified therapy for myocardial protection against doxorubicin-induced cardiotoxicity / Amy Faulk, Volkmar Weissig, and Tamer Elbayoumi -- Formation of pit-spanning phospholipid bilayers on nanostructured silicon dioxide surfaces for studying biological membrane events / Indriati Pfeiffer and Michael Zach -- Characterization of nanoparticle-lipid membrane interactions using QCM-D / Rickard Frost and Sofia Svedhem -- Single-cell nanosurgery / Maxwell B. Zeigler and Daniel T. Chiu -- Single quantum dot imaging in living cells / Jerry C. Chang and Sandra J. Rosenthal -- Fabrication of fluorescent silica nanoparticles with aggregation-induced emission luminogens for cell imaging / Sijie Chen, Jacky W.Y. Lam, and Ben Zhong Tang -- Monitoring the degradation of reduction-sensitive gene carriers with fluorescence spectroscopy and flow cytometry / Constantin Hozsa, Miriam Breunig, and Achim Gopferich -- Quantification of intracellular mitochondrial displacements in response to nanomechanical forces displacements in response to nanomechanical forces / Yaron R. Silberberg and Andrew E. Pelling -- Imaging select mammalian organelles using fluorescent microscopy : application to drug delivery / Paul D.R. Dyer [and others] -- Real-time particle tracking for studying intracellular trafficking of pharmaceutical nanocarriers / Feiran Huang [and others] -- Interactions of nanoparticles with proteins : determination of equilibrium constants / Lennart Treuel and Marcelina Malissek -- Tracing the endocytic pathways and trafficking kinetics of cell signaling receptors using single QD nanoparticles / Katye M. Fichter and Tania Q. Vu -- Cellular internalization of quantum dots / Yue-Wern Huang [and others] -- Electrochemical scanning tunneling microscopy and spectroscopy for single-molecule investigation / Andrea Alessandrini and Paolo Facci -- Intracellular delivery of biologically active proteins with peptide-based carriers / Seong Loong Lo and Shu Wang -- Lipo-oligoarginine-based intracellular delivery / Jae Sam Lee and Ching-Hsuan Tung -- Fluorescent spherical monodisperse silica core-shell nanoparticles with a protein-binding biofunctional shell / Achim Weber, Marion Herz, and Gunter E.M. Tovar -- Direct quantification of PTD transduction using real-time monitoring / Mi-Sook Lee and Song Her -- Genotoxic assessment of carbon nanotubes / Olivera Neskovic [and others] -- Separation science : principles and applications for the analysis of bionanoparticles by asymmetrical flow field-flow fractionation (AF4) / Alexandre Moquin, Francoise M. Winnik, and Dusica Maysinger -- Polymersomes-mediated delivery of fluorescent probes for targeted and long-term imaging in live cell microscopy / Irene Canton and Giuseppe Battaglia -- Protocol for the preparation of stimuli-responsive gold nanoparticles capped with elastin-based pentapeptides / Vincent Lemieux, P. Hans H.M. Adams, and Jan C.M. van Hest.
- 2007 ScienceDirectMcIntosh, J. Richard.Physics of Rapid Cooling and Its Implications for Cryoimmobilization of Cells / J. Dubochet -- Cryopreparation Methods for Electron Microscopy of Selected Model Systems / K. McDonald -- Cryopreparation Methodology for Plant Cell Biology / M. W. Hess -- Correlative Light and Electron Microscopy of Early Caenorhabditis elegans Embryos in Mitosis / T. Muller-Reichert -- Understanding Microtubule Organizing Centers by Comparing Mutant and Wild-Type Structures with Electron Tomography / E. T. O'Toole -- Whole-Cell Investigation of Microtubule Cytoskeleton Architecture by Electron Tomography / J. L. Hoog -- Electron Microscopy of Archaea / C. E. Robertson -- Reconstructing Mammalian Membrane Architecture by Large Area Cellular Tomography / B. J. Marsh -- Visualization of Membrane-Cytoskeletal Interactions During Plant Cytokinesis / M. S. Otegui -- Electron Tomographic Methods for Studying the Chemical Synapse / C. P. Arthur -- Using Electron Microscopy to Understand Functional Mechanisms of Chromosome Alignment on the Mitotic Spindle / B. F. McEwen -- Electron Microscopic Analysis of the Leading Edge in Migrating Cells / T. Svitkina -- Imaging Actomyosin In Situ / K. A. Taylor -- Electron Tomography of Bacterial Chemotaxis Receptor Assemblies / P. Zhang -- How to "Read" a Vitreous Section / J. Dubochet -- Single-Particle Electron Cryomicroscopy of the Ion Channels in the Excitation-Contraction Coupling Junction / I. I. Serysheva -- Electron Microscopy of Microtubule-Based Cytoskeletal Machinery / A. Hoenger -- Reconstructing the Endocytotic Machinery / Y. Cheng -- 3D Immunolocalization with Plastic Sections / M. K. Morphew -- Electron Microscopy Analysis of Viral Morphogenesis / A. Pelchen-Matthews -- Electron Tomography of Immunolabeled Cryosections / M. S. Ladinsky -- Visualizing Macromolecules with Fluoronanogold: From Photon Microscopy to Electron Tomography / T. Cheutin -- Markers for Correlated Light and Electron Microscopy / G. E. Sosinsky -- Localizing Specific Elements Bound to Macromolecules by EFTEM / R. D. Leapman -- Localization of Protein Complexes by Pattern Recognition / C. Best -- The Application of Energy-Filtered Electron Microscopy to Tomography of Thick, Selectively Stained Biological Samples / J. C. Bouwer -- Optimization of Image Collection for Cellular Electron Microscopy / P. Mooney -- Future Directions for Camera Systems in Electron Microscopy / N. Xuong -- Structure Determination In Situ by Averaging of Tomograms / F. Forster -- Methods for Image Segmentation in Cellular Tomography / K. Sandberg -- Database Resources for Cellular Electron Microscopy / M. E. Martone.Also available: Print – 2007
- 2009 SpringerEhnholm, Christian.
- v. 1-4, 1999-2002. Springer
- v. 5-, 2002- Springer
- 2010 SpringerBundgaard, Jens R.; Rehfeld, Jens F.
- 2012 SpringerLuzi, Livio.1. Human Evolution and Physical Exercise: The Concept of Being "Born to Run" / Livio Luzi -- 2. Cell Morphology and Function: The Specificities of Muscle Cells / Anna Maestroni -- 3. The Cell Membrane of the Contractile Unit / Gianpaolo Zerbini -- 4. Gene Polymorphisms and Athletic Performance / Ileana Terruzzi -- 5. Nutrients and Whole-Body Energy Metabolism: The Impact of Physical Exercise / Stefano Benedini -- 6. Mitochondrial and Non-mitochondrial Studies of ATP Synthesis / Roberto Codella -- 7. Excessive Nutrients and Regional Energy Metabolism / Gianluca Perseghin -- 8. Muscle Biopsy To Investigate Mitochondrial Turnover / Rocco Barazzoni -- 9. Introduction to the Tracer-Based Study of Metabolism In Vivo / Andrea Caumo and Livio Luzi -- 10. Physical Activity and Inflammation / Raffaele Di Fenza and Paolo Fiorina -- 11. The HPA Axis and the Regulation of Energy Balance / Francesca Frigerio -- 12. Physical Exercise in Obesity and Anorexia Nervosa / Alberto Battezzati and Simona Bertoli -- 13. Physical Exercise and Transplantation / Valentina Delmonte, Vincenzo Lauriola, Rodolfo Alejandro and Camillo Ricordi -- 14. The Baboon as a Primate Model To Study the Physiology and Metabolic Effects of Exercise / Francesca Casiraghi, Alberto Omar Chavez, Nicholas Musi and Franco Folli.
- 2012 ClinicalKeyBlaustein, Mordecai P.; Kao, Joseph P. Y.; Matteson, Donald R.Introduction : homeostasis and cellular physiology -- Diffusion and permeability -- Osmotic pressure and water movement -- Electrical consequences of ionic gradients -- Ion channels -- Passive electrical properties of membranes -- Generation and propagation of the action potential -- Ion channel diversity -- Electrochemical potential energy and transport processes -- Passive solute transport -- Active transport -- Synaptic physiology I -- Synaptic physiology II -- Molecular motors and the mechanism of muscle contraction -- Excitation-contraction coupling in muscle -- Mechanics of muscle contraction.
- 2013 CRCnetBASEScianna, Marco; Preziosi, Luigi."All biological phenomena emerge from an intricate interconnection of multiple processes occurring at different levels of organization: namely, at the molecular, the cellular and the tissue level, see Figure 1. These natural levels can approximately be connected to a microscopic, mesoscopic, and macroscopic scale, respectively. The microscopic scale refers to those processes that occur at the subcellular level, such as DNA synthesis and duplication, gene dynamics, activation of receptors, transduction of chemical signals, diffusion of ions and transport of proteins. The mesoscopic scale, on the other hand, can refer to cell-level phenomena, such as adhesive interactions between cells or between cells and ECM components, cell duplication and death and cell motion. The macroscopic scale finally corresponds to those processes that are typical of multicellular behavior, such as population dynamics, tissue mechanics and organ growth and development. It is evident that research in biology and medicine needs to work in a multiscale fashion. This brings many challenging questions and a complexity that can not be addressed in the classical way, but can take advantage of the increasing collaboration between natural and exact sciences (for more detailed comments the reader is referred to [90, 262]). On the other hand, the recent literature provides evidence of the increasing attention of the mathematical, statistical, computational and physical communities toward biological and biomedical modeling, consequence of the successful results obtained by a multidisciplinary approach to the Life Sciences problems"-- Provided by publisher.
- 2009 SpringerApte, Shireesh P.; Sarangarajan, Rangaprasad.
- 2009 SpringerUgarković, Đurđica.
- 2012 SpringerSchatten, Heide.Part I. Centrosomes in Reproduction -- 1. Centriole Duplication and Inheritance in Drosophila melanogaster / Tomer Avidor-Reiss, Jayachandran Gopalakrishnan, Stephanie Blachon and Andrey Polyanovsky -- 2. Sperm Centrioles and Their Dual Role in Flagellogenesis and Cell Cycle of the Zygote: Structure, Function, and Pathology / Hector E. Chemes -- 3. Centrosomal Functions and Dysfunctions in Cat Spermatozoa / Pierre Comizzoli and David E. Wildt -- 4. Nuclear-Centrosome Relationships During Fertilization, Cell Division, Embryo Development, and in Somatic Cell Nuclear Transfer Embryos / Heide Schatten and Qing-Yuan Sun -- 5. Human Centrosomal Dynamics During Gametogenesis, Fertilization, and Embryogenesis and Its Impact on Fertility: Ultrastructural Analysis / A. Henry Sathananthan -- 6. Asymmetric Centrosome Behavior in Stem Cell Divisions / Therese M. Roth, Yukiko M. Yamashita and Jun Cheng -- Part II. Cell and Molecular Biology of Centrosomes -- 7. Functional Associations Between the Golgi Apparatus and the Centrosome in Mammalian Cells / Breanne Karanikolas and Christine Sütterlin -- 8. Many Pathways to Destruction: The Role of the Centrosome in, and Its Control by Regulated Proteolysis / Harold A. Fisk -- 9. Regulation of the Centrosome Cycle by Protein Degradation / Suzanna L. Prosser and Andrew M. Fry -- 10. Molecular Links Between Centrosome Duplication and Other Cell Cycle-Associated Events / Kenji Fukasawa -- 11. Regulation of Centrosomes by Cyclin-Dependent Kinases / Rose Boutros -- Part III. Centrosome Abnormalities in Cancer -- 12. Disruption of Centrosome Duplication Control and Induction of Mitotic Instability by the High-Risk Human Papillomavirus Oncoproteins E6 and E7 / Nina Korzeniewski and Stefan Duensing -- 13. Centrosomes, DNA Damage and Aneuploidy / Chiara Saladino, Emer Bourke and Ciaran G. Morrison -- 14. Centrosome Regulation and Breast Cancer / Zeina Kais and Jeffrey D. Parvin -- 15. The Role of Centrosomes in Multiple Myeloma / Benedict Yan and Wee-Joo Chng -- 16. Centrosomal Amplification and Related Abnormalities Induced by Nucleoside Analogs / Ofelia A. Olivero -- 17. Mechanisms and Consequences of Centrosome Clustering in Cancer Cells / Alwin Krämer, Simon Anderhub and Bettina Maier -- Part IV. Centrosomes in Other Systems -- 18. Re-evaluation of the Neuronal Centrosome as a Generator of Microtubules for Axons and Dendrites / Peter W. Baas and Aditi Falnikar -- 19. Centrosomes and Cell Division in Apicomplexa / Leandro Lemgruber, Marek Cyrklaff and Freddy Frischknecht -- 20. The Centrosome Life Story in Xenopuslaevis / Jacek Z. Kubiak and Claude Prigent -- 21. Role of the MTOC in T Cell Effector Functions / Martin Poenie, Laura Christian, Sarah Tan and Yuri Sykulev -- 22. Thoughts on Progress in the Centrosome Field / Jeffrey L. Salisbury.
- 2015 ScienceDirectBasto, Renata; Oegema, Karen.This new volume of Methods in Cell Biology looks at methods for analyzing centrosomes and centrioles. Chapters cover such topics as methods to analyze centrosomes, centriole biogenesis and function in multi-ciliated cells, laser manipulation of centrosomes or CLEM, analysis of centrosomes in human cancers and tissues, proximity interaction techniques to study centrosomes, and genome engineering for creating conditional alleles in human cells.
- 2001 ScienceDirectDavis, Trisha N.; Palazzo, Robert E.Also available: Print – 2001
- 2013 SpringerShibasaki, Masakatsu.At the forefront of life sciences today is the emerging discipline of chembiomolecular science. This new term describes the integration of the frontier fields of chemical biology, chemistry, and pharmacology. Chembiomolecular science aims to elucidate new biological mechanisms as potential drug targets and enhance the creation of new drug therapies. This book comprises the proceedings of the Uehara Memorial Foundation Symposium 2011, which focused on the most recent advances in chembiomolecular science made by leading experts in the field. The book is divided into three main topics. The first is the chemical approach to understanding complex biological systems on a molecular level using chemical compounds as a probe. The second describes the biological approach used to develop new lead drug compounds. The third focuses on the biological system that serves as the potential drug target, the beginning step in the process of developing new drugs. Replete with the latest research, the book will draw the attention of all scientists interested in the synergies between chemistry and biology to elucidate life on a molecular level and to promote drug discovery. Ultimately, the book helps promote the understanding of biological functions at the molecular level and create new pharmaceuticals that can contribute to improving human health.
- 2006 SpringerJaroch, S.; Weinmann, Hilmar.
- v. 1-3, 1970.Balazs, Endre A.v. 1. Collagen, basal laminae elastin --v. 2. Glycosaminoglycans and proteoglycans --v. 3. Structural organization and function of the matrix.
- 2006 SpringerLaurent, Brehon Curtis.
- 2009 Springer ProtocolsChellappan, Srikumar P.Preparation of chromatin assembly extracts from preblastoderm Drosophila embryos / Edgar Bonte and Peter B. Becker -- Analysis of reconstituted chromatin using a solid-phase approach / Raphael Sandaltzopoulos and Peter B. Becker -- In vivo chromatin decondensation assays : molecular genetic analysis of chromatin unfolding characteristics of selected proteins / Sherry L. Winter, Philip Wong, and Mark G. Alexandrow -- DNA methyltransferase probing of chromatin structure within populations and on single molecules / Carolina Pardo ... [et al.] -- Visualization of the expression of HMGN nucleosomal binding proteins in the developing mouse embryo and in adult mouse tissues / Takashi Furusawa and Michael Bustin -- Drug-induced premature chromosome condensation (PCC) protocols : cytogenetic approaches in mitotic chromosome and interphase chromatin / Eisuke Gotoh -- Analysis of DNA topology in yeast chromatin / Randall H. Morse -- Preparation and analysis of uniquely positioned mononucleosomes / Daria A. Gaykalova ... [et al.] -- Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy / Michael J. Kruhlak, Arkady Celeste, and André Nussenzweig -- Methods to study transcription-coupled repair in chromatin / Hélène Gaillard, Ralf Erik Wellinger, and Andrés Aguilera -- Cytometric analysis of DNA damage : phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs) / Toshiki Tanaka ... [et al.] -- Detection of DNA damage induced by topoisomerase II inhibitors, gamma radiation, and crosslinking agents using the comet assay / Lori A. Hazlehurst -- Analysis of genomic aberrations using comparative genomic hybridization of metaphase chromosomes / Melanie Carless -- In vitro replication assay with mammalian cell extracts / Wasia Rizwani and Srikumar P. Chellappan -- Investigation of genomic methylation status using methylation-specific and bisulfite sequencing polymerase chain reaction / Melanie Carless -- Biochemical analysis of arginine methylation in transcription / Marc Tini, Hina Naeem, and Joseph Torchia -- In vitro histone demethylase assays / Kenji Kokura and Jia Fang -- Histone chaperone as coactivator of chromatin transcription : role of acetylation / Shrikanth S. Gadad ... [et al.] -- Histone deacetylase activity assay / Zhigang Yuan ... [et al.] -- In vitro and in vivo assays for studying histone ubiquitination and deubiquitination / Ling Zhai, Heui-Yun Joo, and Hengbin Wang -- Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining / Jaya Padmanabhan -- Chromatin immunoprecipitation assays : analyzing transcription factor binding and histone modifications in vivo / Smitha Pillai, Piyali Dasgupta, and Srikumar P. Chellappan -- ChIP on Chip assays : genome-wide analysis of transcription factor binding and histone modifications / Smitha Pillai and Srikumar P. Chellappan -- ChIP-on-Chip analysis methods for Affymetrix tiling arrays / Sean J. Yoder and Steven A. Enkemann -- Non-radioactive assay methods for the assessment of telomerase activity and telomere length / Partha P. Banerjee and Shankar Jagadeesh -- Detecting ATM-dependent chromatin modification in DNA damage and heat shock response / Sandeep Misri, Shruti Pandita, and Tej K. Pandita.
- 2015 Springer ProtocolsChellappan, Srikumar P.Updated and revised, this thorough volume is organized such that it begins with techniques related to the study of chromatin structure. Protocols for reconstitution of chromatin on solid supports for analysis, preparation of positioned mononucleosomes, techniques to study premature chromatin condensation, and the use of comparative genomic hybridization to assess genomic aberration are included as well. Novel techniques for imaging chromatin using atomic force microscopy and the isolation of specific genomic regions using engineered DNA binding molecules generated by CRISPR are then examined. That section is followed by protocols to analyze DNA and histone modifications, while the third section includes methods to study DNA replication and repair, in the context of chromatin. Last but not least, protocols for studying chromatin and its relation with transcriptional regulation are presented in a fourth section. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and up-to-date, Chromatin Protocols, Third Edition aims to help researchers in facilitating in-depth molecular analysis of various aspects of chromatin structure and function.
- 2010Snider, Alyssa Christine; Crabtree, Gerald R.; Fuller, Margaret T.; Lipsick, Joseph Steven; Scott, Matthew P.; Wysocka, Joanna.Early embryonic cell types such as the zygote, blastomeres of the preimplantation embryo, and embryonic stem (ES) cells have powerful chromatin remodeling activities that facilitate DNA-dependent processes such as transcription and DNA repair. Chd1l encodes a chromatin remodeling factor and is more highly expressed in the inner cell mass (ICM) compared to the whole blastocyst. Chd1l expression is developmentally regulated during a time course of preimplantation development and is present in ES cells. Intriguing expression patterns suggested Chd1l could be a novel regulator of DNA-dependent processes in early developmental cell types. This dissertation describes research undertaken to address the role of Chd1l in chromatin remodeling in the preimplantation embryo and in ES cells. Reducing Chd1l protein to nearly undetectable levels in ES cells reveals that Chd1l is dispensable for ES cell viability, proliferation, and pluripotent morphology. Global gene expression patterns are unaltered by Chd1l knock-down. Chd1l is also dispensable for expression patterns of lineage markers associated with the formation of the primary germ layers in differentiating embryoid bodies. Zygote-stage embryos injected with Chd1l-MO arrest prior to the morula stage. Knock-down by the MO was confirmed at the transcript levels by microfluidic qPCR, and the arrest phenotype was partially rescued upon co-injection of Chd1l mRNA and Chd1l-MO. ES cells are known to have stringent and unique pathways to repair DNA damage to prevent mutation and genomic instability from arising in the organism. Reduction of Chd1l in ES cells confers resistance to induced DNA damage, a finding that contrasts with another study that used a differentiated cell line. Apoptosis induced by over-expression of Chd1l occurs specifically in ES cells and not in their differentiated counterparts. This switch in the effect of Chd1l over-expression during differentiation suggests that the function of Chd1l is very different in ES cells than in differentiated somatic cells. DNA repair through non-homologous end joining (NHEJ) is particularly critical in the zygote to repair the paternal genome. Differentiated somatic cells, but not ES cells also rely heavily on NHEJ. Biochemical evidence supports the involvement of Chd1l in NHEJ. Deficient DNA repair could underlie the Chd1l arrest phenotype. Therefore, Chd1l functions minimally, or not at all, in regulating gene expression and contributes to the DNA damage response in a developmental stage-specific and/or cell type-specific manner.
- 2010Toro, Esteban; Burkholder, William; Kingsley, David M.; Shapiro, Lucy; Villeneuve, Anne.Bacterial chromosomes are generally ~1000 times longer than the cells in which they reside, and concurrent replication, segregation, and transcription/translation of this crowded mass of DNA poses a challenging organizational problem. At first, it was assumed that DNA is organized randomly inside the cell, much like a bowl of spaghetti. Furthermore, it was argued that segregation of this disordered mass was not carried out by a mitotic machinery as is found in eukaryotes, but rather the by-product of cell growth. Hence, the canonical description of bacterial DNA was that of an unstructured polymer diffusing randomly. Recent advances in cell imaging technology, however, have revealed that the bacterial nucleoid is reliably oriented and highly organized within the cell. Furthermore, the speed of segregation is inconsistent with the old model driven by cell growth. Here, I use a screening approach to identify parS, a 100bp piece of DNA previously found to be anchored to the old cell pole, as the Caulobacter centromere. In direct contrast to other published models, parS segregates ahead of all other sequences, including the origin of replication (Cori), and moving parS away from Cori causes segregation -- but not replication -- to be delayed. The segregation of parS requires the ATPase activity of the ParA protein, and current work is aimed at understanding the molecular details of this process. All of these data point to the presence of an active, mitotic-like machine that drives chromosome segregation in Caulobacter. I also show that the circular Caulobacter chromosome is oriented in relation to the parS anchor site at the old cell pole, so that changing the genomic position of parS causes the entire chromosome to rotate within the cell. Finally, I find that the chromosome is organized into a dense core running down the length of the cell, and I arrive at two possible models for the large-scale structure of this core. Thus, this work forms part of an emerging view of the chromosome as a highly organized structure that is kept in place by simple yet active mechanisms, and whose segregation is insured by a complex dedicated machine.
- 2009 ScienceDirectKing, Stephen M.; Pazour, Gregory J.
- 2009 ScienceDirectKing, Stephen M.; Pazour, Gregory J.
- pt. A-B, 2013 ScienceDirectpt. B ScienceDirectMarshall, Wallace F.
- 2009 ScienceDirectKing, Stephen M.; Pazour, Gregory J.
- 2011 Springer ProtocolsTurksen, Kursad.Measuring size-dependent permeability of the tight junction using PEG profiling / Christina M. Van Itallie and James M. Anderson -- Biochemical analysis of claudin-binding compatibility / Christina Ward and Michael Koval -- Electrophysiological Characterization of Claudin Ion Permeability Using Stably Transfected Epithelial Cell Lines / Alan S.L. Yu -- Tight junction, intercellular seal as a cell signaling player : protocols for examination of its status / Makoto Osanai -- Interactions between Clostridium perfringens enterotoxin and claudins / Susan L. Robertson and Bruce A. McClane -- Biophysical methods to probe claudin-mediated adhesion at the cellular and molecular level / Sri Ram Krishna Vedula [and others] -- Detection of tight junction barrier function in vivo by biotin / Lei Ding [and others] -- Coculture method to examine interactions between claudin isoforms in tight junction-free HEK293 cells and tight junction-bearing MDCK II cells / Tetsuichiro Inai -- Claudin-4 : functional studies beyond the tight junction / Holly A. Eckelhoefer [and others] -- Methods to analyze subcellular localization and intracellular trafficking of claudin-1 / P. Jaya Kausalya and Walter Hunziker -- Claudin family proteins in Caenorhabditis elegans / Jeffrey S. Simske and Jeff Hardin -- In vivo imaging of tight junctions using claudin-EGFP transgenic medaka / Tatsuo Miyamoto, Mikio Furuse, and Makoto Furutani-Seiki -- Claudins in a primary cultured puffer fish (Tetraodon nigroviridis) gill epithelium / Phuong Bui and Scott P. Kelly -- Manipulating claudin expression in avian embryos / Michelle M. Collins and Aimee K. Ryan -- Identification of claudins by western blot and immunofluorescence in different cell lines and tissues / Lorenza Gonzalez-Mariscal, Erika Garay, and Miguel Quiros -- Expression and function of claudins in hepatocytes / Takashi Kojima and Norimasa Sawada -- Analysis of changes in the expression pattern of claudins using salivary acinar cells in primary culture / Junko Fujita-Yoshigaki -- Development of biological tools to study claudins in the male reproductive tract / Daniel G. Cyr [and others] -- Using molecular tracers to assess the integrity of the intestinal epithelial barrier in vivo / Julian A. Guttman -- Laboratory methods in the study of endometrial claudin-4 / Paulo Serafini [and others] -- Role of claudins in oxidant-induced alveolar epithelial barrier dysfunction / Yu Sun, Richard D. Minshall, and Guochang Hu -- Tracing the endocytosis of claudin-5 in brain endothelial cells / Svetlana M. Stamatovic, Richard F. Keep, and Anuska V. Andjelkovic -- Quantitative in situ analysis of claudin expression at the blood-retinal barrier / Heping Xu and Janet Liversidge -- MMP-mediated disruption of claudin-5 in the blood-brain barrier of rat brain after cerebral ischemia / Yi Yang and Gary A. Rosenberg -- Claudin-5 expression in in vitro models of the blood-brain barrier / Itzik Cooper, Katayun Cohen-Kashi-Malina, and Vivian I. Teichberg -- HIV-1-induced alterations of claudin-5 expression at the blood-brain barrier level / Ibolya E. Andras and Michal Toborek -- Enhanced immunohistochemical resolution of claudin proteins in glycolmethacrylate-embedded tissue biopsies / Jane E. Collins [and others] -- Claudin-16/paracellin-1, cloning, expression, and its role in tight junction functions in cancer and endothelial Cells / Tracey A. Martin and Wen G. Jiang -- Dynamics of claudins expression in colitis and colitis-associated cancer in rat / Yoshiaki Arimura, Kanna Nagaishi, and Masayo Hosokawa -- Anti-claudin-4-conjugated highly luminescent nanoparticles as biological labels for pancreatic cancer sensing / Ken-Tye Yong.
- 2011 SpringerLuan, Sheng.Plant cell calcium, past and future / Anthony J. Trewavas -- Calcium signalilng and homeostasis in nuclei / Christian Mazars .. [et al.] --Interactions between calcium and ROP signaling regulate pollen tube tip growth / Augusta Jamin and Zhenbiao Yang -- Calcium, mechanical signaling, and tip growth / Won-Gyu Choi, Sarah J. Swanson, and Simon Gilroy -- Calcium signals in the control of stomatal movements / Alex A.R. Webb and Fiona C. Robertson -- Stimulus perception and membrane excitation in unicellular alga Chlamydomonas / Kenjiro Yoshimura -- Cyclic nucleotide gated channels (CNGCs) and the generation of Ca2+ signals / Wei Ma and Gerald A. Berkowitz -- Annexins / Anuphon Laohavisit and Julia M. Davies -- Structure and function of CDPK : a sensor responder of calcium / Yohsuke Takahashi and Takeshi Ito -- Elucidation of calcium-signaling components and networks / Irene S. Day and A.S.N. Reddy -- Decoding of calcium signal through calmodulin : calmodulin-binding proteins in plants / Liqun Du [and others] / The CBL-CIPK network for decoding calcium signals in plants / Oliver Batistic [and others].
- Abstracts of papers presented at the LXXIII Cold Spring Harbor Symposium on Quantitative Biology : control & regulation of stem cells, May 28-June 2, 2008 — Coding and decoding of calcium signals in plants (167)
- Color atlas of immunocytochemistry in diagnostic cytology — Koss's Cytology of the urinary tract with histopathologic correlations (167)
- Laboratory methods in cell biology : biochemistry and cell culture. 1st ed. — Plant cell wall : methods and protocols (167)
- Pluripotency in domestic animal cells — Zebrafish. Cellular and developmental biology. Part A. 3rd ed. (165)
- Harrison's Principles of Internal Medicine
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Includes cited reference searching, citation maps, and an analyze tool.
Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.
Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.
Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.
In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.
A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.
Over 10,000 notes outline the status of specific infections within each country.
Provides online, full-text access to Springer's journal titles as well as journals from other publishers.
Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.