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Cell BiologyAccess restricted to Stanford unless otherwise noted

  • Chromatin protocols. 2nd ed. 2009, Springer Protocols
    Preparation of chromatin assembly extracts from preblastoderm Drosophila embryos / Edgar Bonte and Peter B. Becker -- Analysis of reconstituted chromatin using a solid-phase approach / Raphael Sandaltzopoulos and Peter B. Becker -- In vivo chromatin decondensation assays : molecular genetic analysis of chromatin unfolding characteristics of selected proteins / Sherry L. Winter, Philip Wong, and Mark G. Alexandrow -- DNA methyltransferase probing of chromatin structure within populations and on single molecules / Carolina Pardo ... [et al.] -- Visualization of the expression of HMGN nucleosomal binding proteins in the developing mouse embryo and in adult mouse tissues / Takashi Furusawa and Michael Bustin -- Drug-induced premature chromosome condensation (PCC) protocols : cytogenetic approaches in mitotic chromosome and interphase chromatin / Eisuke Gotoh -- Analysis of DNA topology in yeast chromatin / Randall H. Morse -- Preparation and analysis of uniquely positioned mononucleosomes / Daria A. Gaykalova ... [et al.] -- Monitoring DNA breaks in optically highlighted chromatin in living cells by laser scanning confocal microscopy / Michael J. Kruhlak, Arkady Celeste, and André Nussenzweig -- Methods to study transcription-coupled repair in chromatin / Hélène Gaillard, Ralf Erik Wellinger, and Andrés Aguilera -- Cytometric analysis of DNA damage : phosphorylation of histone H2AX as a marker of DNA double-strand breaks (DSBs) / Toshiki Tanaka ... [et al.] -- Detection of DNA damage induced by topoisomerase II inhibitors, gamma radiation, and crosslinking agents using the comet assay / Lori A. Hazlehurst -- Analysis of genomic aberrations using comparative genomic hybridization of metaphase chromosomes / Melanie Carless -- In vitro replication assay with mammalian cell extracts / Wasia Rizwani and Srikumar P. Chellappan -- Investigation of genomic methylation status using methylation-specific and bisulfite sequencing polymerase chain reaction / Melanie Carless -- Biochemical analysis of arginine methylation in transcription / Marc Tini, Hina Naeem, and Joseph Torchia -- In vitro histone demethylase assays / Kenji Kokura and Jia Fang -- Histone chaperone as coactivator of chromatin transcription : role of acetylation / Shrikanth S. Gadad ... [et al.] -- Histone deacetylase activity assay / Zhigang Yuan ... [et al.] -- In vitro and in vivo assays for studying histone ubiquitination and deubiquitination / Ling Zhai, Heui-Yun Joo, and Hengbin Wang -- Detection of histone H3 phosphorylation in cultured cells and tissue sections by immunostaining / Jaya Padmanabhan -- Chromatin immunoprecipitation assays : analyzing transcription factor binding and histone modifications in vivo / Smitha Pillai, Piyali Dasgupta, and Srikumar P. Chellappan -- ChIP on Chip assays : genome-wide analysis of transcription factor binding and histone modifications / Smitha Pillai and Srikumar P. Chellappan -- ChIP-on-Chip analysis methods for Affymetrix tiling arrays / Sean J. Yoder and Steven A. Enkemann -- Non-radioactive assay methods for the assessment of telomerase activity and telomere length / Partha P. Banerjee and Shankar Jagadeesh -- Detecting ATM-dependent chromatin modification in DNA damage and heat shock response / Sandeep Misri, Shruti Pandita, and Tej K. Pandita.
  • Cilia, motors and regulation 2009, ScienceDirect
  • Cilia. Part A-B pt. A-B, 2013, ScienceDirect
    Pt. B ScienceDirect
  • Plant cell calcium, past and future / Anthony J. Trewavas -- Calcium signalilng and homeostasis in nuclei / Christian Mazars .. [et al.] --Interactions between calcium and ROP signaling regulate pollen tube tip growth / Augusta Jamin and Zhenbiao Yang -- Calcium, mechanical signaling, and tip growth / Won-Gyu Choi, Sarah J. Swanson, and Simon Gilroy -- Calcium signals in the control of stomatal movements / Alex A.R. Webb and Fiona C. Robertson -- Stimulus perception and membrane excitation in unicellular alga Chlamydomonas / Kenjiro Yoshimura -- Cyclic nucleotide gated channels (CNGCs) and the generation of Ca2+ signals / Wei Ma and Gerald A. Berkowitz -- Annexins / Anuphon Laohavisit and Julia M. Davies -- Structure and function of CDPK : a sensor responder of calcium / Yohsuke Takahashi and Takeshi Ito -- Elucidation of calcium-signaling components and networks / Irene S. Day and A.S.N. Reddy -- Decoding of calcium signal through calmodulin : calmodulin-binding proteins in plants / Liqun Du [and others] / The CBL-CIPK network for decoding calcium signals in plants / Oliver Batistic [and others].
  • Principles of model building : an experimentation-aided approach to development of models for signaling networks / Ambhighainath Ganesan and Andre Levchenko -- Integrated inference and analysis of regulatory networks from multi-level measurements / Christopher S. Poultney, Alex Greenfield, and Richard Bonneau -- Swimming upstream : identifying proteomic signals that drive transcriptional changes using the interactome and multiple "-omics" datasets / Shao-shan Carol Huang and Ernest Fraenkel -- A framework for modeling the relationship between cellular steady-state and stimulus-responsiveness / Paul M. Loriaux and Alexander Hoffmann -- Stochastic modeling of cellular networks / Jacob Stewart-Ornstein and Hana El-Samad -- Quantifying traction stresses in adherent cells / Casey M. Kraning-Rush ... [et al.] -- CellOrganizer : image-derived models of subcellular organization and protein distribution / Robert F. Murphy -- Spatial modeling of cell signaling networks / Ann E. Cowan ... [et al.] -- Stochastic models of cell protrusion arising from spatiotemporal signaling and adhesion dynamics / Erik S. Welf and Jason M. Haugh -- Nonparametric variable selection and modeling for spatial and temporal regulatory networks / Anil Aswani ... [et al.] -- Quantitative models of the mechanisms that control genome-wide patterns of animal transcription factor binding / Tommy Kaplan and Mark D. Biggin -- Computational analysis of live cell images of the Arabidopsis thaliana plant / Alexandre Cunha ... [et al.] -- Multi-scale modeling of tissues using CompuCell3D / Maciej H. Swat ... [et al.] -- Multiscale model of fibrin accumulation on the blood clot surface and platelet dynamics / Zhiliang Xu ... [et al.].
  • Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
  • ch. 1. Cell Culture -- ch. 2. Preparation and Isolation of Cells -- ch. 3. Subcellular Fractionation and Isolation of Organelles -- ch. 4. Microscopy -- ch. 5. Characterization of Cellular Proteins -- ch. 6. Electrophoresis and Immunoblotting -- ch. 7. Protein Labeling and Immunoprecipitation -- ch. 8. Cell Cycle Analysis -- ch. 9. Cell Adhesion -- ch. 10. Extracellular Matrix -- ch. 11. In Vitro Reconstitution -- ch. 12. Cell Motility -- ch. 13. Organelle Motility -- ch. 14. Signal Transduction: Protein Phosphorylation -- ch. 15. Protein Trafficking -- ch. 16. Antibodies as Cell Biological Tools -- ch. 17. Macromolecular Interactions in Cells -- ch. 18. Cellular Aging and Death -- ch. 19. Whole Organism and Tissue Analysis -- ch. 20. Expression and Introduction of Macromolecules into Cells -- ch. 21. Fluorescent Protein Technology -- ch. 22. Cell Biology of Chromosomes and Nuclei -- ch. 23. Stem Cells -- ch. 24. Lipids -- ch. 25. Nanotechnology -- ch. 26. Viruses -- ch. 27. RNA-Based Methods in Cell Biology -- Appendix 1. Useful Information and Data -- Appendix 2. Laboratory Stock Solutions and Equipment -- Appendix 3. Commonly Used Techniques -- Appendix. Suppliers.
  • Consists of a core publication dated Apr. 1997, and updated by supplements 1 (July 1997)-<57 (July 2010)>. Content is peer-reviewed protocols for flow and image cytometry updated quarterly.
  • Includes methods for isolating, maintaining, and differentiating embryonic and adult stem cells.
  • Cytokines 2011, CRCnetBASE
    1. General and cellular aspects -- 2. Life style factor and life events -- 3. Immunology and infections -- 4. Cancer -- 5. Cardiovascular and metabolic disease -- 6. Organs and tissue systems.
  • In recent decades, cytopathology has assumed an increasing role in the primary diagnosis of mass lesions owing to its ability to provide rapid, non-invasive, and timely information. With cytopathology at the forefront of diagnosis and prognostication of neoplastic lesions, it is essential that physicians involved in the diagnosis and treatment of precancerous lesions and cancer have a clear understanding of specimen collection techniques, terminology for reporting, and outcomes in various diagnostic categories. This book provides a comprehensive overview of the role of cytology at various body sites. The diagnostic details covered are abbreviated in comparison with those in pathology texts. Instead, a more clinical approach is taken, with the focus on the advantages and limitations of techniques and the key features of entities that are important to clinicians. Pathological clinical correlation is highlighted throughout the book, ensuring that it will be highly relevant for clinicians. In particular, physicians who deal with oncology patients will find it to be a rich source of guidance on how to use and understand cytopathology in the diagnosis and exclusion of malignancy.
  • & Quot;Soft Tissue Cytopathology" by Anil V. Parwani, MD, PhD and Walid E. Khalbuss, MD, PhD, will fulfill the need for an easy-to-use and authoritative synopsis of soft tissue cytopathology. This volume, part of "The Essentials in Cytopathology book series," fits into the lab coat pocket and is ideal for portability and quick reference. Each volume in the series is heavily illustrated with a full color art program, while the text follows a user-friendly outline format. Anil V. Parwani, MD, PhD, is Associate Professor of Pathology at the University of Pittsburgh Medical Center - S.
  • Cytopreparation 2013, Springer
    Cytopreparation: Principles & Practice by Gary W. Gill fills a long-standing need for an easy-to-use and authoritative manual on the fundamentals of cytopreparation up-to-and- including microscopy, screening, and data analysis. The text describes in phenomenological terms the most common materials and methods of specimen collection through mounting for gyn, non-gyn, and FNA specimens, as well as the underlying mechanistic bases. The author provides his expertise and information that will empower and enable readers to review and improve their laboratories' cytopreparatory techniques as they apply to the vast majority of specimens. This unique volume provides facts that are not readily available anywhere. Cytopreparation: Principles & Practice is intended for everyone associated with, and involved in, making cytologic preparations that are useful for their intended purpose. It will serve as a valuable reference tool for educators in cytology and histology, cytotechnology and histotechnology students, cytotechnologists, cytopreparatory technicians, cytopathologists, anatomical/clinical pathologists, pathology residents and cytopathology fellows.
  • Part 1.Basics of the Cytoskeleton --ACTIN /Vera Dugina, Richard Arnoldi, Paul A. Janmey and Christine Chaponnier --Microtubules /Pavel Dráber and Eduarda Dráberová --The Kinesin Superfamily /Linda Wordeman --Basics of the Cytoskeleton: Myosins /Omar A. Quintero, Judy E. Moore and Christopher M. Yengo --Part 2.Actin and Disease --The Actin Cytoskeleton and Membrane Organisation in T Lymphocytes /Rhea Cornely, Thomas Grewal and Katharina Gaus --Thin Filament Diseases of Striated Muscle /Anthony J. Kee and Edna C. Hardeman --Filamins and Disease /Stephen P. Robertson and Philip B. Daniel --LIM Kinase and Cancer Metastasis /Alice Schofield and Ora Bernard --Actin Mutations and Deafness /Matías Morín, Fernando Mayo, Felipe Moreno and Miguel A. Moreno-Pelayo --Therapeutic Targeting of the Actin Cytoskeleton in Cancer /Teresa Bonello, Jason Coombes, Galina Schevzov, Peter Gunning and Justine Stehn --Part 3.Microtubules and Disease --Microtubules as a Target in Cancer Therapy /April L. Risinger and Susan L. Mooberry --Microtubules, Drug Resistance, and Tumorigenesis /Joshua A. McCarroll and Maria Kavallaris --Posttranslational Modifications of Tubulin /Suzan K. Chao, Chia-Ping H. Yang and Susan Band Horwitz --Stathmin and Cancer /Dominic Chi Hiung Ng and Frances Byrne --The Biology and Pathobiology of Tau Protein /Garth F. Hall --Tubulin-Related Malformations of Cortical Development /Xavier H. Jaglin, Jamel Chelly and Nadia Bahi-Buisson --Part 4.Intermediate Filaments and Disease --Spectrins in Human Diseases /Marie-Christine Lecomte --Laminopathies /Nadir M. Maraldi and Giovanna Lattanzi --Desmin and Heart Disease /J. Scott Pattison and Jeffrey Robbins --Neurodegenerative Diseases and Intermediate Filaments /Rodolphe Perrot and Jean-Pierre Julien.
  • Central axonal development and pathology in early life / Robin L. Haynes and Hannah C. Kinney -- Microtubules in the nervous system / Nobuyuki Fukushima -- Tau phosphorylation / Jesús Avila and Félix Hernández -- Tau pathology / Nicolas Sergeant and Luc Buée -- Tauopathy and brain aging / Akihiko Takashima -- Microtubule-associated protein 4 / Kiyotaka Tokuraku ... [et al.] -- Structure of neural intermediate filaments / David A.D. Parry -- Alpha-internexin: the fourth subunit of neurofilaments in the mature CNS / Aidong Yuan and Ralph A. Nixon -- Peripherin pathology / Jesse R. McLean and Janice Robertson -- Neurofilament cross-bridge: a structure associated specifically with the neurofilament among the intermediate filament family / Takahiro Gotow -- Neurofilament transport / Andrew J. Grierson and Christopher C.J. Miller -- Knockout models of neurofilament proteins / Rodolphe Perrot and Jean-Pierre Julien -- Neurofilaments and radial growth: deconstruction of a hypothesis through the construction of gene targeted mice / Michael L. Garcia and Devin M. Barry -- Deregulation of cytoskeletal protein phosphorylation and neurodegeneration / Jyotshnabala Kanungo ... [et al.] -- Neurofilaments in aged animals / Shin-ichi Hisanaga, Takahiro Sasaki, and Atsuko Uchida -- Neurofilament changes in multiple sclerosis / Elizabeth Gray and Alastair Wilkins -- Intermediate filament interactions in neurons / Kevin G. Young and Rashmi Kothary -- Tropomyosins in neuronal morphogenesis and development / Nikki Margarita Curthoys, Peter William Gunning, and Thomas Fath -- The driving machinery for growth cone navigation / Takuro Tojima and Hiroyuki Kamiguchi -- Glial fibrillary acidic protein: the intermediate filament protein of astrocytes / Douglas L. Eng and Lawrence F. Eng -- Axonal transport mechanisms in cytoskeleton formation and regulation / Aidong Yuan and Ralph A. Nixon -- Axonal transport and motor neuron disease / Anna-Lena Ström ... [et al.] -- In vivo imaging of axonal transport in aging and Alzheimer's disease / Donna J. Cross and Satoshi Minoshima -- Regulation of cytoskeletal composition in neurons: transcriptional and post-transcriptional control in development, regeneration, and disease / Ben G. Szaro and Michael J. Strong -- Crosstalks between myelinating cells and the axonal cytoskeleton / Rodolphe Perrot and Joël Eyer -- Topographic regulation of neuronal intermediate filament proteins by phosphorylation: in health and disease / Parvathi Rudrabhatla and Harish C. Pant -- Cytoskeleton, axonal transport, and the mechanisms of axonal neuropathy / Hsinlin T. Cheng ... [et al.] -- Effects of insulin on tau and neurofilament / R. Schechter and K.E. Miller -- Ethanol effects on the cytoskeleton of nerve tissue cells / Sergio G. Evrard and Alicia Brusco.
  • The role of TNF in cancer / Harald Wajant -- Many checkpoints on the road to cell death: regulation of Fas-FasL interactions and Fas signaling in peripheral immune responses / Madhu Ramaswamy ... [et al.] -- FasL expression and reverse signaling / M. Lettau ... [et al.] -- Impact of TNF-R1 and CD95 internalization on apoptotic and antiapoptotic signaling / Stefan Schütze and Wulf Schneider-Brachert -- Ubiquitination and TNFR1 signaling / Ken-ichi Fujita and Srinivasa M. Srinivasula -- From biochemical principles of apoptosis induction by TRAIL to application in tumour therapy / Stefanie M. Cordier, Kerstin Papenfuss, and Henning Walczak -- Therapeutic targeting of TWEAK/Fn14 in cancer: exploiting the intrinsic tumor cell killing capacity of the pathway / Jennifer S. Michaelson and Linda C. Burkly -- APRIL in B-cell malignancies and autoimmunity / Fiona C. Kimberly, Jan Paul Medema, and Michael Hahne -- Autophagy in cancer and chemotherapy / Shida Yousefi and Hans-Uwe Simon -- Glucocorticoid-mediated apoptosis resistance of solid tumors / Ingrid Herr, Markus W. Büchler, and Jürgen Mattern -- Targeting death-receptors in radiation therapy / Olivier Niemöller and Claus Belka -- Death ligands designed to kill: development and application of targeted cancer therapeutics based on proapoptotic TNF family ligands / Jeannette Gerspach, Harald Wajant, and Klaus Pfizenmaier.
  • Dental pulp stem cells 2013, Springer
    Dental Evolution -- Tooth development -- Dental Pulp is a Connective Tissue -- Dental Pulp Stem Cells (DPSC) -- Isolation methods of DPSC -- Characterization of DPSC -- Reprogramming of DPSC to induced pluripotent stem cells (iPSC) -- Immunomodulatory effects of DPSC -- Dental Pulp is a Complex Adaptive System.
  • Following their own brilliant careers in haeme protein research, the outstanding scientists Jonathan and Beatrice Wittenberg continue to provide inspiration to the research community in the study of oxygen-binding proteins. Their research has provided the intellectual stimulus to bring together scientists from all over the world with the common goal of developing fascinating new ideas and performing innovative experiments. This book is dedicated to Jonathana (TM)s and Beaa (TM)s lifetime careers. It further illuminates the facts and ideas which dot the paths they traced in Biochemistry and Physiology, elaborating on how these landmark achievements were made and how the haeme proteins community still refers to them. With the field of haeme protein science such a flourishing area, the contributors to this book predict Jonathan and Bea, having played such a seminal role, will continue to be key figures for quite some time to come.
  • The secretory capacity of a cell depends on the efficiency of endoplasmic reticulum-associated degradation / M. Molinari and R. Sitia -- Recognition and delivery of ERAD substrates to the proteasome and alternative paths for cell survival / A.A. McCracken and J.L. Brodsky -- CPY* and the power of yeast genetics in the elucidation of quality control and associated protein degradation of the endoplasmic reticulum / D.H. Wolf and A. Schäfer -- The role of the ubiquination machinery in dislocation and degradation of endoplasmic reticulum proteins / M. Kikkert, G. Hassink, and E. Wiertz -- The role of p97/Cdc48p in endoplasmic reticulum-associated degradation : from the immune system to yeast / S. Bar-Nun -- The ins and outs of intracellular peptides and antigen presentation by MHC Class I molecules / T. Groothuis and J. Neefjes -- Entry of protein toxins into mammalian cells by crossing the endoplasmic reticulum membrane : co-opting basic mechanisms of endoplasmic reticulum-associated degradation / J.M. Lord , L.M. Roberts, and W.I. Lencer.
  • The HIF-2[alpha]-driven pseudo-hypoxic phenotype in tumor aggressiveness, differentiation, and vascularization / A. Pietras, A.S. Johnsson and S. Pahlman -- Hypoxia and hypoxia inducible factors in cancer stem cell maintenance / Z. Li and J.N. Rich -- Role of carcinoma-associated fibroblasts and hypoxia in tumor progression / A.J. Giaccia and E. Schipani -- The role of hypoxia regulated microRNAs in cancer / R. McCormick ... [et al.] -- Oxygen sensing: A common crossroad in cancer and neurodegeneration / A. Quaegebeur and P. Carmeliet -- Hypoxia-inducible factors as essential regulators of inflammation / H.Z. Imtiyaz and M.C. Simon -- Hypoxia and metastasis in breast cancer / H. Rundqvist and R.S. Johnson.
  • The existence of 'cancer stem cells' (CSCs) has been a topic of heated debate for the last few years within the field of cancer biology. Their continuous characterization in a variety of solid tumors has lead to an abundance of evidence supporting their existence. CSCs are believed to be responsible for resistance against conventional treatment regimes of chemotherapy and radiation, ultimately, leading to metastasis and patient demise. To help aid clinicians, pharmaceutical companies and academic labs investigating how to better kill these highly aggressive cells we have summarized the DNA repair mechanism(s) and their role in the maintenance and regulation of both normal and cancer stem cells. Our book represents a comprehensive investigation into the highly effective DNA repair mechanisms of CSCs and what we need to understand in order to develop more advanced therapies to eradicate them from patients. Currently, there are no other published works entirely on DNA repair and Cancer Stem Cells. In addition, our book provides a comprehensive overview of CSC isolation and characterization from a variety of solid tumor types.
  • In humans, male infertility is caused by a number of factors such as the external environment, nutrient changes, genotoxins, and mutagens. This book discusses the events that occur in the normal sperm head and govern the structure-function relationship from the time of spermatogenesis to that of fertilization or egg activation.
  • Dyneins. 1st ed. 2012, ScienceDirect
    Research on dyneins has a direct impact on human diseases, such as viruses and cancer. With an accompanying website showing over one hundred streaming videos of cell dynamic behavior for best comprehension of material, Dynein: Structure, Biology and Disease is the only reference covering the structure, biology and application of dynein research to human disease. From bench to bedside, Dynein: Structure, Biology and Disease offers research on fundamental cellular processes to researchers and clinicians across developmental biology, cell biology, molecular biology, biophysics, biomedicine, genetics and medicine. . Broad-based up-to-date resource for the dynein class of molecular motors . Chapters written by world experts in their topics . Numerous well-illustrated figures and tables included to complement the text, imparting comprehensive information on dynein composition, interactions, and other fundamental features.
  • ECTO-NOX proteins 2013, Springer
    "ENOX Proteins" documents a unique family of cell surface proteins which are the exclusive discovery (subsequently confirmed by others) of the authors, their students and their colleagues. An ENOX-based mechanism is provided for how cells increase in size that is both unique and applicable not only to cancer and cancer therapy but also to production agriculture and biomass increase. The role of ENOX proteins in biological time-keeping is described along with evidence for oscillations in the ratios of electron spin pairs defining ortho and para water states that form highly coordinated populations of coherent water of interest to physicists as the underlying mechanism. The age-related NADH oxidases that appear around age 30 and increase steadily thereafter with potentially causal involvements in atherogenesis and skin aging have been identified as five members of the TM-9 protein superfamily of all with different chromosomal locations. The arNOX proteins initially are membrane anchored but functionally-active N-terminal fragments that are shed into body fluids. Except for critical functional motifs, all of the ENOX protein family members have distinct protein sequences and chromosomal origins. A fourth member of the ENOX protein family occurs in plants as the primary target for both natural and synthetic growth hormone (auxin)-stimulated rapid cell enlargement. Despite masquerading as intractable and difficult to clone and characterize, ENOX proteins offer remarkable opportunities for research, commercial development and outside confirmation of new paradigms to help explain complex biological processes.
  • Electric Cell-Substrate Impedance Sensing Concept to Commercialization /Ivar Giaever and Charles R. Keese --Protein Kinase C Isoforms in the Formation of Focal Adhesion Complexes: Investigated by Cell Impedance /Havovi Chichger, Katie L. Grinnell and Elizabeth O. Harrington --ECIS as a Tool in the Study of Metastasis Suppressor Genes: Epithelial Protein Lost In Neoplasm (EPLIN) /Andrew J. Sanders, Vladimir M. Saravolac, Malcolm D. Mason and Wen G. Jiang --Electrical Cell-Substrate Impedance Sensing for Measuring Cellular Transformation, Migration, Invasion, and Anticancer Compound Screening /Bryan Plunger, Chang Kyoung Choi and Tim E. Sparer --Epithelial-Mesenchymal Transition and the Use of ECIS /Jane Lane and Wen G. Jiang --Cell Growth and Cell Death Studied by Electric Cell-Substrate Impedance Sensing /Judith Anthea Stolwijk, Stefanie Michaelis and Joachim Wegener --Tight Junctions in Cancer Metastasis and Their Investigation Using ECIS (Electric Cell-Substrate Impedance Sensing) /Tracey A. Martin and Wen G. Jiang --Epithelial Wound Healing and the Effects of Cytokines Investigated by ECIS: Electric Cell-Substrate Impedance Sensing in Epithelial Research /Katalin Szaszi, Matthew Vandermeer and Yasaman Amoozadeh --Tumour-Endothelial and Tumour-Mesothelial Interactions Investigated by Impedance Sensing Based Cell Analyses /Wen G. Jiang, Lin Ye, Haiying Ren, Ann Kift-Morgan and Nicholas Topley, et al. --Application of Electric Cell-Substrate Impedance Sensing in Evaluation of Traditional Medicine on the Cellular Functions of Gastric and Colorectal Cancer Cells /Lin Ye, Ke Ji, Jiafu Ji, Rachel Hargest and Wen G. Jiang --Electric Cell-Substrate Impedance Sensing as a Screening Tool for Wound Healing Agents /Cheuk Lun Liu, Jacqueline Chor Wing Tam, Andrew J. Sanders, David G. Jiang and Chun Hay Ko, et al. --ECIS, Cellular Adhesion and Migration in Keratinocytes /David C. Bosanquet, Keith G. Harding and Wen G. Jiang --Current and Future Applications of ECIS Models to Study Bone Metastasis /Lin Ye, Sivan M. Bokobza, Howard G. Kynaston and Wen G. Jiang.
  • Chapter 1. Electron Microscopy of Viruses -- Chapter 2. Bacterial TEM : New Insights from Cryo-Microscopy -- Chapter 3. Analysis of the Ultrastructure of Archaea by Electron Microscopy -- Chapter 4. Chlamydomonas : Cryopreparation Methods for the 3-D Analysis of Cellular Organelles -- Chapter 5. Ultrastructure of the Asexual Blood Stages of Plasmodium falciparum -- Chapter 6. Electron Tomography and Immuno-labeling of Tetrahymena thermophila Basal Bodies -- Chapter 7. Electron Microscopy of Paramecium (Ciliata).
  • Embryonic stem cell protocols. 2nd ed. v. 1-2, 2006, Springer Protocols
    v. 2, 2006 Springer Protocols
    v. 1. Isolation and characterization -- v. 2. Differentiation models.
  • Embryonic stem cells 2006, ScienceDirect
    Derivation and maintenance of embryonic stem cells -- Differentiation of embryonic stem cells.
  • Embryonic stem cells 2007, Springer
    Defined culture media for human embryonic stem cells / T. Ludwig and J. Thomson -- Generation of disease-specific human embryonic stem cell lines / S. Minger -- Characterization and differentiation of human embryonic stem cells / A. Laslett ... [et al.] -- Genetic modification of human embryonic stem cells / T. Zwaka -- Hematopoietic differentiation / C. Cerdan ... [et al.] -- Neural differentiation / Z.-J. Zhang ... [et al.] -- Germ cell differentiation / V. Angeles and R. Pera -- Mesodermal differentiation / N. Sharon and N. Benvenisty -- Three-dimensional culture of human embryonic stem cells / S. Gerecht ... [et al.] -- Extraembryonic cell differentiation / L. Armstrong and M. Lako -- Pancreatic cell differentiation / B. Fishman ... [et al.] -- Cardiomyocyte differentiation / D. Singla ... [et al.] -- Human embryonal carcinoma (EC) cells: Complementary tools for embryonic stem cell research / P. Tonge and P. Andrews -- Quality control of human stem cell lines / G. Stacey.
  • In biochemistry, a metalloprotein is a generic term for a protein that contains a metal cofactor. The metal may be an isolated ion or may be coordinated with a nonprotein organic compound, such as the porphyrin found in hemoproteins. In some cases, the metal is co-coordinated with a side chain of the protein and an inorganic nonmetallic ion. This kind of protein-metal-nonmetal structure is seen in iron-sulfur clusters Metalloproteins deals with all aspects related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The biological roles of metal cations and metal-binding proteins are endless. They are involved in all crucial cellular activities. Many pathological conditions are related to the problematic metal metabolism. Research in metalloprotein-related topics is therefore rapidly growing, and different aspects of metal-binding proteins progressively enter curricula at Universities and even at the High School level on occasion. However, no key resource providing basic, but comprehensible knowledge on this rapidly expanding field exists. The Encyclopedia of Metalloproteins aims to bridge this gap, and will attempt to cover various aspects of metalloprotein/metalloproteomics and will deal with the different issues related to the intracellular and extracellular metal-binding proteins, including their structures, properties and functions. The goal is to cover exhaustively all catalytically and biologically crucial metal ions and to find at least one interacting protein for other metal ions. The Encyclopedia of Metalloproteins will provide a key resource for advanced undergraduate and graduate students, researchers, instructors, and professors interested in protein science, biochemistry, cell biology, and genetics.
  • Endocrine emergencies 2014, Springer
  • The Endoplasmic Reticulum (ER) is an organelle with extraordinary signaling and homeostatic functions. It is the organelle responsible for protein folding, maturation, quality control and trafficking of proteins destined for the plasma membrane or for secretion into the extracellular environment. Failure, overloading or malfunctioning of any of the signaling or quality control mechanisms occurring in the ER may provoke a stress condition known as âER stressâ. Accumulating evidence indicates that ER stress may dramatically perturb interactions between the cell and its environment, and contribute to the development of human diseases, ranging from metabolic diseases and cancer to neurodegenerative diseases, or impact therapeutic outcome. This book primarily focuses on the pathophysiology of ER stress. It introduces the molecular bases of ER stress, the emerging relevance of the ER-mitochondria cross-talk, the signaling pathways engaged and cellular responses to ER stress, including the adaptive Unfolded Protein Response (UPR), autophagy as well as cell death. Next the book addresses the role of ER stress in physiology and in the etiology of relevant pathological conditions, like carcinogenesis and inflammation, neurodegeneration and metabolic disease. The last chapter describes how ER stress pathways can be targeted for therapeutic benefit. Altogether, this book will provide the reader with an exhaustive view of ER stress biology and the latest insights in the role of ER stress in relevant human diseases.
  • Endosome signalling. Part A-B. First edition. pt. A-B, 2014, ScienceDirect
    Pt. B ScienceDirect
  • Endothelial cytoskeleton 2014, CRCnetBASE
    The endothelial cytoskeleton : multifunctional role of the endothelial actomyosin cytoskeleton / Yuka Shimizu and Joe G.N. Garcia -- Emerging themes on pulmonary microvascular endothelial cell : microtubules and microtubule associated proteins / Cristiaan D. Ochoa, Ron Balczon, and Troy Stevens -- Endothelial actin cytoskeleton and angiogenesis / Sadiqa K. Quadri -- Adherens junctions and endothelial cytoskeleton / Younes Smani and Tarik Smani-Hajami -- Mechanical force transmission via the cytoskeleton in vascular endothelial cells / Bori Mazzag ... [et al.] -- The functional role of the microtubule/microfilament cytoskeleton in the regulation of pulmonary vascular endothelial barrier / Irina B. Alieva and Alexander D. Verin -- Membrane-cytoskeleton interactions and control of vesicle trafficking in endothelial cells / Felicia Antohe -- Cell-matrix adhesion proteins in the regulation of endothelial permeability / Jurjan Aman, Geerten P. van Nieuw Amerongen, and Victor W.M. van Hinsbergh -- Endothelial cells and the regulation of platelet function / P.C. Redondo ... [et al.].
  • Epithelial cell culture protocols 2002, Springer Protocols
  • Erythropoiesis: an overview / B.E. Torbett and J.S. Friedman -- Regulation of endogenous erythropoietin production / D.R. Mole and P.J. Ratcliffe -- Biology of erythropoietin / G. Molineux and A.M. Sinclair -- Erythropoiesis - genetic abnormalities / J.T. Prchal and X.T. Gregg -- Studies of erythropoiesis and the discovery and cloning of recombinant human erythropoietin / M.A. Foote -- Commercial production of recombinant erythropoietins / A.S. Chuck ... [et al.] -- Biosimilar epoetins / H. Schellekens -- New molecules and formulations / S.G. Elliott -- Structural basis for the signal transduction of erythropoietin / T.D. Osslund -- Intracellular signaling by the erythropoietin receptor / H.F. Lodish ... [et al.] -- Mechanism of erythropoietin receptor activation / S.N. Constantinescu -- Pharmacokinetics of erythropoiesis-stimulating agents / S. Doshi ... [et al.] -- Use of erythropoietic stimulating agents in the setting of renal disease / D.A. Goodkin -- Abuse of recombinant erythropoietins and blood products by athletes / D.H. Catlin and C.K. Hatton -- Role and regulation of iron metabolism in erythropoiesis and disease / T.L. Arvedson and B.J. Sasu -- Nonhematopoietic effects of erythropoiesis-stimulating agents / W. Jelkmann, R. Depping and E. Metzen.
  • Basic Research/Mechanisms --A Historical Overview and Concepts of Mesenchymal Stem Cells /Shihua Wang, Robert Chunhua Zhao --Biology of MSCs Isolated from Different Tissues /Simone Pacini --Secretome of Mesenchymal Stem Cells /Yuan Xiao ... [et al.] --Immunomodulatory Properties of Mesenchymal Stem Cells and Related Applications /Lianming Liao, Robert Chunhua Zhao --Mesenchymal Stem Cell Homing to Injured Tissues /Yaojiong Wu, Robert Chunhua Zhao --Major Signaling Pathways Regulating the Proliferation and Differentiation of Mesenchymal Stem Cells /Joseph D. Lamplot ... [et al.] --MicroRNAs in Mesenchymal Stem Cells /Mohammad T. Elnakish, Ibrahim A. Alhaider, Mahmood Khan --Genetic Modification of MSCs for Pharmacological Screening /Jie Qin, Martin Zenke --Control of Mesenchymal Stem Cells with Biomaterials /Sandeep M. Nalluri, Michael J. Hill, Debanjan Sarkar --Clinical Translation --Mesenchymal Stem Cells for Cardiovascular Disease /Wei Wu, Shuyang Zhang --Mesenchymal Stem Cells as Therapy for Graft Versus Host Disease: What Have We Learned? /Partow Kebriaei ... [et al.] --Mesenchymal Stem Cells for Liver Disease /Feng-chun Zhang --Mesenchymal Stem Cells for Bone Repair /Hongwei Ouyang, Xiaohui Zou, Boon Chin Heng, Weiliang Shen --Mesenchymal Stem Cells for Diabetes and Related Complications /Vladislav Volarevic, Majlinda Lako, Miodrag Stojkovic --Mesenchymal Stromal Cell (MSC) Therapy for Crohn's Disease /Jignesh Dalal --The Summary of Stroke and Its Stem Cell Therapy /Renzhi Wang ... [et al.] --Mesenchymal Stem Cell Transplantation for Systemic Lupus Erythematosus /Lingyun Sun --International Regulations and Guidelines Governing Stem Cell Based Products --Considerations of Quality Control Issues for the Mesenchymal Stem Cells-Based Medicinal Products /Bao-Zhu Yuan ... [et al.] --Regulations/Ethical Guidelines on Human Adult/Mesenchymal Stem Cell Clinical Trial and Clinical Translation /Xiaomei Zhai, Renzong Qiu.
  • Introduction to stem cells -- Basic biology/mechanisms -- Tissue and organ development -- Methods -- Applications -- Regulation and ethics.
  • Pt. 1. Research biobanking : the traditional approach -- Consent to biobank research : one size fits all? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- What no one knows cannot hurt you : the limits of informed consent in the emerging world of biobanking / Arthur L. Caplan -- Users and uses of the biopolitics of consent : a study of DNA banks / Pascal Ducournau and Anne Cambon-Thomsen -- Information rights on the edge of ignorance / Anne Maria Skrikerud -- The dubious uniqueness of genetic information / Anne Maria Skrikerud -- Duties and rights of biobank participants : principled autonomy, consent, voluntariness and privacy / Lars Øystein Ursin -- Biobanking and disclosure of research results : addressing the tension between professional boundaries and moral intuition / Lynn G. Dressler -- Biobanks and our common good / Erik Christensen -- Trust, distrust and co-production : the relationship between research biobanks and donors / Pascal Ducournau and Roger Strand -- Scientific citizenship, benefit, and protection in population-based research / Vilhj́almur Árnason -- Pt. 2. Research Biobanking : towards a new conceptual approach -- Mapping the language of research biobanking : an analogical approach / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The use of analogical reasoning in umbilical cord blood biobanking / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- The Alexandria plan : creating libraries for human tissue research and therapeutic use / Laurie Zoloth -- The art of biocollections / Anne Hambro Alnæs -- The health dugnard : biobank participation as the solidary pursuit of the common good / Lars Øystein Ursin and Berge Solberg -- Embodied gifting : reflections on the role of information in biobank recruitment / Klaus Hoeyer -- Conscription to biobank research? / Bjørn Hofmann, Jan Helge Solbakk, Søren Holm -- Ownership rights in research biobanks : do we need a new king of 'biological property'? / Paula Lobato de Faria -- Legal challenges and strategies in the regulation of research biobanking / Elisabeth Rynning -- Annexation of life : the biopolitics of industrial biology / Jan Reinert Karlsen and Roger Strand -- In the ruins of Babel : should biobank regulations be harmonized / Jan Reinert Karlsen, Jan Helge Solbak, and Roger Strand.
  • The evolution of single cells into multicellular organisms was mediated, in large part, by the extracellular matrix. The proteins and glycoconjugates that make up the extracellular matrix provide structural support to cellular complexes, facilitate cell adhesion and migration, and impart mechanical properties that are important for tissue function. Each class of ECM macromolecule has evolved to incorporate distinctive properties that are defined by conserved modules that are mixed together to achieve appropriate function. This volume provides a comprehensive analysis of how the major ECM components evolved over time in order to fill their specific roles found in modern organisms. The major focus is on the structural matrix proteins, matricellular proteins, and more complex ECM structures such as basement membranes. Adhesive proteins and their receptors are also discussed.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
  • Extracellular matrix 2011, Springer
    An overview of extracellular matrix structure and function /Jürgen EngelandMatthias Chiquet --Fibronectin and other adhesive glycoproteins /Jielin XuandDeane Mosher --Collagens, suprastructures, and collagen fibril assembly /David E. BirkandPeter Brückner --Basement membranes /Jeffrey H. Miner --Hyaluronan and the aggregating proteoglycans /Thomas N. Wight,Bryan P. Toole,andVincent C. Hascall --Small leucine-rich proteoglycans /Renato V. Iozzo... [et al.] --Microfibrils and fibrillin /Dirk HubmacherandDieter P. Reinhardt --Elastin /Beth A. Kozel,Robert P. Mecham,andJoel Rosenbloom --Lysyl oxidase and lysyl oxidase-like enzymes /Herbert M. KaganandFaina Ryvkin --The fibulins /Marion A. CooleyandW. Scott Argraves --Matricellular proteins /David D. RobertsandLester F. Lau.
  • Matrix metalloproteinases and their inhibitors in turnover and degradation of extracellular matrix / Sean E. Gill and William C. Parks -- Role of cysteine cathepsins in extracellular proteolysis / Dieter Brömme and Susan Wilson -- Cooperation between proteolysis and endocytosis in collagen turnover / Thomas H. Bugge and Niels Behrendt -- Pericellular proteolysis / Judith S. Bond, Timothy R. Keiffer, and Qi Sun -- Triple helicase activity and the structural basis of collagenolysis / Hideaki Nagase and Robert Visse -- Structural basis of extracellular matrix interactions with matrix metalloproteinases / Steven R. Van Doren -- The role of matrix metalloproteinases in cellular invasion and metastasis / Elena I. Deryugina and James P. Quigley -- Degradation of bone and the role of osteoclasts, bone lining cells and osteocytes / Vincent Everts and Paul Saftig -- Consequences of elastolysis / A. McGarry Houghton, Majd Mouded, and Steven D. Shapiro.
  • Cells in the developing embryo depend on signals from the extracellular environment to help guide their differentiation. An important mediator in this process is the extracellular matrix - secreted macromolecules that interact to form large protein networks outside the cell. During development, the extracellular matrix serves to separate adjacent cell groups, participates in establishing morphogenic gradients, and, through its ability to interact directly will cell-surface receptors, provides developmental clocks and positional information. This volume discusses how the extracellular matrix influences fundamental developmental processes and how model systems can be used to elucidate ECM function. The topics addressed range from how ECM influences early development as well as repair processes in the adult that recapitulate developmental pathways.The series Biology of Extracellular Matrix is published in collaboration with the American Society for Matrix Biology.
  • Articular cartilage is a unique and highly specialized avascular connective tissue in which the availability of oxygen and glucose is significantly lower than synovial fluid and plasma. Glucose is an essential source of energy during embryonic growth and fetal development and is vital for mesenchymal cell differentiation, chondrogenesis and skeletal morphogenesis. Glucose is an important metabolic fuel for differentiated chondrocytes during post-natal development and in adult articular cartilage and is a common structural precursor for the synthesis of extracellular matrix glycosaminoglycans.
  • Introduction and historical perspective -- FNAC technique and slide preparation -- Diagnostic interpretation of FNAC material -- Diagnostic dilemmas in FNAC practice: cystic lesions -- Diagnostic dilemmas in FNAC practice: lymphoid infiltrates -- Diagnostic dilemmas in FNAC practice: metastatic tumours -- Diagnostic dilemmas in FNAC cytology: small round cell tumours -- Diagnostic dilemmas in FNAC cytology: soft-tissue lesions -- Diagnostic dilemmas in FNAC cytology: difficult breast lesions -- Principles of safe practice: the role of FNAC in clinical management -- Principles of safe FNAC practice: FNAC versus core biopsy -- Principles of safe FNAC practice: medicolegal issues.
  • Flow cytometry 2007, Springer
    Principles of flow cytometry / Marion G. Macey -- Cell preparation / Desmond A. McCarthy -- Fluorochromes and fluorescence / Desmond A. McCarthy -- Quality control in flow cytometry / David Barnett and John T. Reilly -- Experimental design, data analysis, and fluorescence quantitation / Mark Lowdell -- Apoptosis detection by flow cytometry / Paul Allen and Derek Davies -- DNA analysis by flow cytometry / Derek Davies and Paul Allen -- Immunological studies of human cells / Ulrika Johansson -- Calcium: cytoplasmic, mitochondrial, endoplasmic reticulum, and flux measurements / Gary Warnes and Marion G. Macey -- Further functional studies / Marion G. Macey -- Cell sorting by flow cytometry / Derek Davies.
  • Flow cytometry protocols. 2nd ed. 2004, Springer Protocols
    Flow cytometry : an introduction / Alice L. Givan -- Multiparameter flow cytometry of bacteria / Howard M. Shapiro and Gerhard Nebe-von-Caron -- Multiparameter data acquisition and analysis of leukocytes / Carleton C. Stewart and Sigrid J. Stewart -- Flow cytometric analysis of kinase signaling cascades / Omar D. Perez, Peter O. Krutzik, and Garry P. Nolan -- Cytokine flow cytometry / Holden T. Maecker -- Use of cell-tracking dyes to determine proliferation precursor frequencies of antigen-specific T cells / Alice L. Givan ... [et al.] -- Assessment of lymphocyte-mediated cytotoxicity using flow cytometry / Luzheng Liu ... [et al.] -- Multiparametric analysis of apoptosis by flow and image cytometry / William G. Telford, Akira Komoriya, and Beverly Z. Packard -- Detection and enrichment of hematopoietic stem cells by side population phenotype / Shannon S. Eaker ... [et al.] -- Hematopoietic stem cell characterization by Hoechst 33342 and Rhodamine 123 staining / Ivan Bertoncello and Brenda Williams --Phenotypic and functional analyses of human CD34neg hematopoietic precursors from mobilized peripheral blood / Douglas C. Dooley and Barbara K. Oppenlander -- Multiparameter flow cytometry of fluorescent protein reporters / Teresa S. Hawley ... [et al.] -- Analysis of fluorescent protein expressing cells by flow cytometry / Steven C. Pruitt, Lawrence M. Mielnicki, and Carleton C. Stewart -- Integrative flow cytometric and microarray approaches for use in transcriptional profiling / David W. Galbraith, Rangasamy Elumalai, and Fang Cheng Gong -- Flow cytometric analysis of fluorescence resonance energy transfer : a tool for high-throughput screening of molecular interactions in living cells / Francis Ka-Ming Chan and Kevin L. Holmes -- Design of a fluorescence-activated cell sorting-based mammalian protein-protein interaction trap / Sam Lievens ... [et al.] -- Flow cytometric screening of yeast surface display libraries / Michael Feldhaus and Robert Siegel -- Fluorescence resonance energy transfer based HIV-1 virion fusion assay -- Marielle Cavrois ... [et al.] -- Cell cycle analysis of asynchronous populations / Michael G. Ormerod -- Solid tumor DNA content analysis / Adel K. El-Naggar and Philippe Vielh --Concurrent flow cytometric analysis of DNA and RNA / Adel K. El-Naggar -- Telomere length measurement by fluorescenece in situ hybridization and flow cytometry / Veena Kapoor and William G. Telford -- Small lasers in flow cytometry / William G. Telford -- Viable infectious cell sorting in a BSL-3 facility / Stephen P. Perfetto ... [et al.].
  • Folding for the synapse 2011, Springer
    Folding for the Synapse addresses the current view on how protein folding and misfolding, controlled by molecular chaperones, contribute to synapse function and dysfunction. Molecular chaperones have been studied in relation to de novo protein folding, but there is increasing awareness that chaperone function is required for the regulation of protein dynamics when functioning physiologically as an isolated moiety or part of a protein complex. This book will introduce both important concepts of folding machineries and give examples of the biological relevance of further chaperone functions.
  • The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
  • A short dictionary of the Pap test -- Analogies in the Pap test : "Of corn flakes and raisins" -- Basic cytology principles -- Basic anatomy and cytology of the female genital tract -- The Bethesda system -- Liquid-based cytology -- Physiological cytology -- Reactive changes and organisms -- Human papillomavirus in cervical carcinogenesis -- Atypical squamous cells -- Low-grade squamous intra-epithelial lesion -- High-grade squamous intra-epithelial lesion -- Invasive squamous carcinoma -- Endocervical lesions -- Endometrial lesions -- Metastatic tumors -- Therapy-related changes -- Artifacts, contaminants, and incidental findings -- Screening and management guidelines of Pap test and newer techniques.
  • This Brief offers a concise, handy overview of the main concepts related to Embryology, revisited through the novel concepts that are applied daily in stem cell research and cell therapy oriented investigations. It is based on three main areas: -The process involved in female gamete differentiation and maturation. The main aspects related to cell biology will be covered and an overview of the epigenetic regulation of gametogenesis will be presented. -Early stages of embryo development with a careful analysis of the regulatory mechanisms driving cleavage, polarization and genome activation. -Stem cell and gametogenesis. The use of the oocyte as a possible source for the derivation of stem cell lines is discussed and depicted as a powerful tool to investigate oocyte potency and asymmetric imprinting. The potential biological implications are evaluated and use of stem cells to derive oocytes is presented.
  • Gasotransmitters 2012, Springer
    "The gases termed gasotransmitters play an increasingly important role in understanding how signalling into and between cells is modulated and fine-tuned. The advent of gasotransmitters has profoundly changed our way of thinking about biosynthesis, liberation, storage and action mechanisms in cellular signaling. In recent years an impressive amount of new data, distributed throughout the existing literature, has been generated. For this book the editors have recruited distinguished colleagues in the field to summarize and review important biological, pharmacological and medical functions and their implications, as well as methods for the detection of gasotransmitters."--P. [4] of cover.
  • Genome integrity 2007, Springer
    From microorganisms to humans, this volume provides an interdisciplinary overview of how genome integrity is maintained. It begins with DNA replication and continues with replicative DNA repair and pleiotropic protein interactions. It also reviews the cellular responses to radiation and genotoxic stress affecting whole genomes.
  • Gliogenesis 2009, Springer
    Gliogenesis -- Astroglia -- Oligodendroglia -- Microglia -- Ependymal cells -- Tanycytes -- Schwann cells.
  • Glioma signaling 2013, Springer
  • Heparan sulfate proteoglycan in inflammation and angiogenesis / Lianchun Wang -- Heparan sulfate proteoglycans in infection / Allison H. Bartlett and Pyong Woo Park -- Glycans in cancer / Lubor Borsig -- Glycosaminoglycans in atherosclerosis and thrombosis / C.P. Vicente, J.A.P. Godoy, and C.C. Werneck -- Glycans in embryonic stem cells / Claire Pickford ... [et al.] -- Heparan sulfate proteoglycans in cancer therapy / Ezeddin Salem Gassar, Sherif A. Ibrahim, and Martin Götte -- Structure and biological activities of glycosaminoglycan analogs from marine invertebrates : new therapeutic agents? / Eliene O. Kozlowski ... [et al.]
  • GTPase protocols 2002, Springer Protocols
  • Hair follicle 2005, Springer
  • Handbook of dynein 2012, CRCnetBASE
    "This book draws together recent data on both cytoplasmic and flagellar dyneins and the proteins they interact with, to give readers a clear picture of what is currently known about the structure and mechanics of these remarkable macro-molecular machines. Each chapter is written by active researchers, with a focus on currently used biophysical, biochemical, and cell biological methods. This is a useful handbook for frontline researchers as well as a textbook for advanced students."--P. [4] of cover.
  • "Reflecting the milestones in the field that have occurred since the publication of the first edition, this book provides an updated tool kit that incorporates conventional as well as modern approaches to tackling biological and medicinal research in the post genomic era. The authors have evaluated, revised, and sometimes replaced all protocols with more efficient, reliable, or simpler ones. The book is also completely reorganized and covers topics of modern "omics" approaches, including genomics, proteomics, and metabolomics. This is followed coverage of the Manipulation of Biological Systems, including RNAi, and the use of microscopy"--Provided by publisher.
  • Quality management and regulation / Jeffrey Prichard -- Technique and troubleshooting of antibody testing / Fan Lin and Jianhui Shi -- Overview of automated immunohistochemistry / Jeffrey Prichard, Angela Bitting, and Joe Myers -- Automated staining : Dako perspective / Ole F. Rasmussen and Andreas Schønau -- Automated staining : Ventana perspective / Angela Sattler -- Tissue microarray / Myra Wilkerson and Erin Powell -- Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens / Fan Lin and Haiyan Liu -- Exfoliative cytopathology / Steven Meschter and Jan F. Silverman -- Predictive markers of breast cancer : ER, PR, and HER2 / Jeffrey Prichard, David Hicks, and Elizabeth Hammond -- Central and peripheral nerve system tumors / Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller -- Thyroid and parathyroid gland / Haiyan Liu, Fan Lin, and Ronald A. DeLellis -- Adrenal gland / Hanna G. Kaspar -- Salivary gland and other head and neck structures / Conrad Schuerch -- Lung, pleura, and mediastinum / Kai Zhang and Phillip Cagle -- Breast / Haiyan Liu -- Uterus / Hanna G. Kaspar -- Ovary / Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson -- Prostate gland / Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai -- Urinary bladder / Myra Wilkerson -- Kidney / Fan Lin and Ximing J. Yang -- Testis and paratesticular tissues / Myra Wilkerson -- Pancreas and ampulla / Fan Lin and Hanlin L. Wang -- Liver, bile ducts, and gallbladder / Jeffrey Prichard and Fan Lin -- Upper gastrointestinal tract / Jinhong Li and Fan Lin -- Lower gastrointestinal tract and microsatellite instability / Jinhong Li and Fan Lin -- Soft tissue and bone tumors / Shaobo Zhu and Markku Miettinen -- Lymph node / Xiaohong (Mary) Zhang and Nadine S. Aguilera -- Bone marrow / R. Patrick Dorion and Xiaohong (Mary) Zhang -- Infectious diseases / Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner -- Skin / Tammie Ferringer -- Application of direct immunofluorescence for the skin and mucosal biopsies : a practical review / William B. Tyler -- In situ hybridization in surgical and cytologic specimens / Hong Yin and Barbara Paynton.
  • Origin and fate of hematopoietic precursors in the early mouse embryo / Julien Yuan Bertrand ... [et al.] -- Hematopoietic development in drosophila: a parallel with vertebrates / Marie Meister and Shubha Govind -- Intraembryonic development of hematopoietic stem cells during human ontogeny: expression analysis / Caroline Marshall -- Gene and cell therapy involving hematopoietic stem cell / Isabelle André-Schmutz and Marina Cavazzana-Calvo.Ventral and dorsal contributions to hematopoiesis in xenopus / Aldo Ciau-Uitz, Maggie Walmsley and Roger Patient -- Genetic dissection of hematopoiesis using the zebrafish / Rebecca A. Wingert and Leonard I. Zon -- Extra- and intraembryonic HSC commitment in the avian model / Thierry Jaffredo ... [et al.] -- Avian lymphopoiesis and transcriptional control of hematopoietic stem cell differentiation / Jussi Liippo and Olli Lassila -- Yolk sac development in mice / James Palis -- Long-term reconstituting hematopoietic stem cell capacity in the embryo / Mervin C. Yoder -- The endothelium: the cradle of definitive hematopoiesis? / Katrin Ottersbach and Elaine Dzierzak -- Endothelial and hematopoietic cells in the intraembryonic compartment / Fumio Arai and Toshio Suda --
  • Stem cell biology / Elizabeth O. Hexner and Stephen G. Emerson -- Stem cell transplantation for hematologic malignancies / Effie W. Petersdorf -- Immunobiology of transplantation / Robert S. Negrin -- Allogeneic and autologous hematopoietic stem cell transplantation for acute lymphoblastic leukemia and acute myelogenous leukemia in the adult / Anthony Stein and Stephen J. Forman -- Hematopoietic cell transplantation for chronic myeloid leukemia / Uday Popat and Sergio Giralt -- Stem cell transplantation for Hodgkin's and non-Hodgkin's lymphomas / John W. Sweetenham -- Transplantation in chronic lymphocytic leukemia / Rifca Le Diew and John G. Gribben -- Stem cell transplantation in multiple myeloma / John Koreth and Kenneth C. Anderson -- Allogeneic hematopoietic cell transplantation for patients with myelodysplastic syndrome and myeloproliferative disorders / Aravind Ramakrishnan and H. Joachim Deeg -- Stem cell transplantation for marrow failure / Philippe Armand and Joseph H. Antin -- Stem cell transplantation for hemoglobinopathies / Catherine J. Wu -- Stem cell sources for allogeneic transplantation / Corey Cutler -- Allogeneic unrelated donor blood and marrow transplantation / Daniel Weisdorf -- Umbilical cord hematopoietic stem cell transplantation / Mitchell E. Horwitz and Nelson Chao -- Haploidentical stem cell transplantation / Bimalangshu R. Dey and Thomas R. Spitzer -- Ablative preparative regimens for hematopoietic stem cell transplantation / Amin Alousi and Marcos de Lima -- Nonmyeloablative transplantation / Frédéric Baron and Brenda M. Sandmaier -- Immune reconstitution after allogeneic transplantation / Carolyn A. Keever-Taylor -- Infection in the hematopoietic stem cell transplant recipient / Francisco M. Marty and Lindsey R. Baden -- EBV lymphoproliferative disease after transplantation / Stephen Gottschalk, Cliona M. Rooney, and Helen E. Heslop -- Hepatic veno-occlusive disease / Erica Linden and Paul Richardson -- Lung injury after hematopoietic stem cell transplantation / Kenneth R. Cooke and Gregory Yanik -- Quality of life issues post-transplantation / Stephanie J. Lee -- Pathophysiology of acute graft-versus-host disease / Pavan Reddy and James L.M. Ferrara -- Acute graft-versus-host disease / Martin Benesch and H. Joachim Deeg -- Chronic Graft-versus-host disease / Javier Bolaños-Meade and Georgia B. Vogelsang -- Graft manipulation : T cell depletion and tumor cell purging / Vincent T. Ho -- Donor lymphocyte infusions : clinical applications and the graft-versus-leukemia effect / Edwin P. Alyea -- Regenerative medicine : application in cardiovascular diseases / Emerson C. Perin, Guilherme V. Silva, and Marlos R. Fernandes.
  • Hepatocyte transplantation 2009, Springer Protocols
    Human hepatocyte transplantation overview / Juliana Puppi and Anil Dhawan -- Isolation of human hepatocytes / Ragai R. Mitry -- An optimised method for cryopreservation of human hepatocytes / Claire Terry and Robin D. Hughes -- Liver cell culture techniques / José V. Castell and María José Gómez-Lechón -- In-vitro assays for induction of drug metabolism / Brian G. Lake ... [et al.] -- Hepatocyte apoptosis / Mustapha Najimi, Françoise Smets, and Etienne Sokal -- Small animal models of hepatocyte transplantation / Jurgen Seppen, Ebtisam El Filali, and Ronald Oude Elferink -- Hepatocyte transplantation techniques : large animal models / Anne Weber, Marie Thérèse Groyer-Picard, and Ibrahim Dagher -- Cell transplant techniques : engraftment detection of cells / Robert A. Fisher and Valeria R. Mas -- Hepatic preconditioning for transplanted cell engraftment and proliferation / Yao-Ming Wu and Sanjeev Gupta -- Ex vivo gene transfer into hepatocytes / Xia Wang ... [et al.] -- Sources of adult hepatic stem cells : haematopoietic / Rosemary Jeffery, Richard Poulsom, and Malcolm R. Alison -- Production of hepatocyte-like cells from human amnion / Toshio Miki ... [et al.] -- Generation of hepatocytes from human embryonic stem cells / Niloufar Safinia and Stephen L. Minger -- Isolation, in vitro cultivation, and characterisation of foetal liver cells / Yue Wu, Chetan C. Shatapathy, and Stephen L. Minger -- Human intrahepatic biliary epithelial cell lineages : studies in vitro / Ruth Joplin and Stivelia Kachilele -- Liver cell labelling with MRI contrast agents / Michel Modo, Thomas J. Meade, and Ragai R. Mitry -- Microbiological monitoring of hepatocyte isolation in the GMP laboratory / Sharon C. Lehec.
  • Hepatocytes 2010, Springer Protocols
    1. General review on in vitro hepatocyte models and their applications / Christiane Guguen-Guillouzo and Andre Guillouzo -- 2. Human foetal hepatocytes / Anne Weber ... [et al.] -- 3. Isolation and culture of primary hepatocytes from resected human liver tissue / Edward L. LeCluyse and Eliane Alexandre -- 4. Optimisation of the cryopreservation of primary hepatocytes / Nicola J. Hewitt -- 5. Cryopreservation of human hepatocytes for clinical use / Ragai R. Mitry, Sharon C. Lehec, and Robin D. Hughes -- 6. Hepatocyte differentiation / Katy M. Olsavsky Goyak, Elizabeth M. Laurenzana, and Curtis J. Omiecinski -- 7. Reversible manipulation of apoptosis sensitivity in cultured hepatocytes by matrix-mediated manipulation of signaling activities / Patricio Godoy ... [et al.] -- 8. Markers and signaling factors for stem cell differentiation to hepatocytes / Frédéric Lemaigre -- 9. Hepatic stem cells / Robert E. Schwartz and Catherine Verfaillie -- 10. Hepatic stem cells and liver development / Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, and Naoya Kobayashi -- 11. Generation of hepatocytes from human embryonic stem cells / Neta Lavon -- 12. Isolation and culture of adult human liver progenitor cells / Sabine Gerbal-Chaloin ... [et al.] -- 13. The HepaRG cell line / Marie-Jeanne Marion, Olivier Hantz, and David Durantel -- 14. Transdifferentiation of pancreatic cells to hepatocytes / Chia-Ning Shen and David Tosh -- 15. Evaluation of drug metabolism, drug-drug interactions and in vitro hepatotoxicity with cryopreserved human hepatocytes / Albert P. Li -- 16. The use of human hepatocytes to investigate drug metabolism and CYP enzyme induction / Sylvie Klieber ... [et al.] -- 17. The use of hepatocytes to investigate UDP-glucuronosyltransferases and sulfotransferases / Sylvie Fournel-Gigleux ... [et al.] -- 18. The use of hepatocytes to investigate drug uptake transporters / Kazuya Maeda and Yuichi Sugiyama -- 19. Metabonomic studies on human hepatocyte in primary culture / Vincent Croizmarie ... [et al.] -- 20. The application of HepRG cells in evaluation of cytochrome P450 induction properties of drug compounds / Tommy B. Andersson -- 21. The use of hepatocytes to investigate drug toxicity / María José Gómez-Lechón, José V. Castell, Maria Teresa Donato -- 22. The use of human hepatocytes to investigate bile acid synthesis / Ewa C.S. Ellis and Lisa-Mari Nilsson -- 23. The use of human hepatocytes to investigate blood coagulation factor / Christine Biron-Andréani ... [et al.] -- 24. Use of human hepatocytes to investigate HCV infection / Lydiane Pichard-Garcia ... [et al.] -- 25. The use of hepatocytes to investigate HDV infection / Camille Sureau -- 26. Rodent models of liver repopulation / Helène Gilgenkrantz -- 27. Chimeric mice with humanized liver / Stephen C. Strom, Julio Davila, and Markus Grompe -- 28. Bioartificial liver support systems / Gesine Pless -- 29. Human hepatocyte transplantation / Anil Dhawan ... [et al.].
  • High content screening 2006, Springer Protocols
  • This volume highlights the most interesting biomedical and clinical applications of high-dimensional flow and mass cytometry. It reviews current practical approaches used to perform high-dimensional experiments and addresses key bioinformatic techniques for the analysis of data sets involving dozens of parameters in millions of single cells. Topics include single cell cancer biology; studies of the human immunome; exploration of immunological cell types such as CD8+ T cells; decipherment of signaling processes of cancer; mass-tag cellular barcoding; analysis of protein interactions by proximity ligation assays; Cytobank, a platform for the analysis of cytometry data; computational analysis of high-dimensional flow cytometric data; computational deconvolution approaches for the description of intracellular signaling dynamics; and hyperspectral cytometry. All 10 chapters of this book have been written by respected experts in their fields. It is an invaluable reference book for both basic and clinical researchers.
  • The Hippo signaling pathway is rapidly gaining recognition as an important player in organ size control and tumorgenesis. This volume presents virtually all aspects of tumor biology because members of the Hippo Pathway have been associated with numerous well-established cell signaling pathways, just to name a few; Rho, Wnt, TGFbeta and p53. Hippo signaling is not solely involved in regulating "classic" tumor characteristics such as cell proliferation, survival and growth, but is also diversely involved in cell-autonomous and non-cell-autonomous differentiation, migration and organ size control. With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.With the multitude of signaling events mediated by the Hippo pathway and the vastly different functions that it plays, it is evident that these tumor suppressors are unique governors of cellular homeostasis. This timely volume gathers wide-ranging and burgeoning information on the Hippo pathway and its role in cancer into an accessible format of a single book.
  • Section 1. Histological and histochemical methods with light microscopy -- section 2. Cytological methods in electron microscopy -- section 3. Image quantification.
  • Histology & cell biology. 5th ed. 2010, AccessMedicine
    Pt 1. Fundamental concepts -- pt 2. The four basic tissue types -- pt 3. Organs and organ systems .
  • Preface -- Host restriction of HIV-1 by APOBEC3 and viral evasion through Vif -- Interactions of viral protein U (Vpu) with cellular factors -- TRIM5alpha -- Human immunodeficiency virus type-1 Gag and host vesicular trafficking pathways -- The roles of tetraspanins in HIV-1 replication -- Imaging of HIV/host protein interactions -- Virological and cellular roles of the transcriptional coactivator LEDGF/p75 -- Implications of Nef: host cell interactions in viral persistence and progression to AIDS -- Vpr and its interactions with cellular proteins.
  • Human adult stem cells 2009, Springer
    1. Neural progenitors / Dustin R. Wakeman ... [et al.] -- 2. Multipotent stromal cells (hMSCs) / Margaret Wolfe ... [et al.] -- 3. Endothelium / Sangmo Kwon, Takayuki Asahara -- 4. Lung / Rabindra Tirouvanziam, Megha Makam, Bruno Péault -- 5. Eye / Maria Notara ... [et al.] -- 6. Colon / F. Iovino ... [et al.] -- 7. Spermatogonia / Makoto C. Nagano, Jonathan R. Yeh, Khaled Zohni -- 8. Hair follicle pluripotent stem (hfPS) cells / Robert M. Hoffman -- 9. Pancreas / Fang-Xu Jiang, Grant Morahan -- 10. Prostate / C. Foley ... [et al.].
  • Human cell culture protocols. 2nd ed. 2005, Springer Protocols
    Establishment and maintenance of normal human keratinocyte cultures / Claire Linge -- Cultivation of normal human epidermal melanocytes in the absence of phorbol esters / Mei-Yu Hsu, Ling Li, and Meenhard Herlyn -- Isolation and culture of human osteoblasts / Alison Gartland ... [et al.] -- Human osteoclast culture from peripheral blood monocytes : phenotypic characterization and quantitation of resorption / Katherine A. Buckley ... [et al.] -- Human chondrocyte cultures as models of cartilage-specific gene regulation / Mary B. Goldring -- Human myoblasts and muscle-derived SP cells / Grace K. Pavlath and Emanuela Gussoni -- Cell cultures of autopsy-derived fibroblasts / Volker Meske, Frank Albert, and Thomas G. Ohm -- Primary culture and differentiation of human adipocyte precursor cells / Vanessa van Harmelen, Thomas Skurk, and Hans Hauner -- Human mononuclear phagocytes in tissue culture / Yona Keisari -- Purification of peripheral blood natural killer cells / Bice Perussia and Matthew J. Loza -- Human fetal brain cell culture / Mark P. Mattson -- Culturing human schwann cells / Victor J. Turnbull --Well-differentiated human airway epithelial cell cultures / M. Leslie Fulcher ... [et al.] -- Isolation and culture of human alveolar epithelial cells / Carsten Ehrhardt, Kwang-Jin Kim, and Claus-Michael Lehr -- A new approach to primary culture of human gastric epithelium / Pierre Chailler and Daniel Ménard -- Isolation and culture of human colon epithelial cells using a modified explant technique employing a noninjurious approach / Hamid A. Mohammadpour -- Isolation and culture of human hepatocytes / Martin Bayliss and Graham Somers -- Glomerular epithelial and mesangial cell culture and characterization / Heather M. Wilson and Keith N. Stewart -- Isolation and culture of human renal cortical cells with characteristics of proximal tubules / Gabrielle M. Hawksworth -- Culture of parathyroid cells / Per Hellman -- Long-term culture and maintenance of human islets of langerhans in Memphis serum-free media / Daniel W. Fraga, A. Osama Gaber, and Malak Kotb -- Primary culture of human antral endocrine and epithelial cells / Susan B. Curtis and Alison M. J. Buchan -- Conjunctiva organ and cell culture / Monica Berry and Marcus Radburn-Smith -- Establishment and maintenance of in vitro cultures of human retinal pigment epithelium / Martin J. Stevens.
  • Pt. 1. Multistep models -- pt. 2. Prostate cancer/stem cells -- pt. 3. Breast cancer/stem cells -- pt. 4. Multistep/genes.
  • Human embryonic stem cell protocols 2006, Springer Protocols
    Human embryonic stem cells: isolation, maintenance and differentiation / Kursad Turksen and Tammy-Claire Troy -- Blastocyst culture for deriving human embryonic stem cells / Ariff Bongso -- Propagation of human embryonic stem cells on human feeder cells / Mark Richards and Ariff Bongso -- Derivation and maintenance of human embryonic stem cells / Michal Amit and Joseph Itskovitz-Eldor -- Isolation and characterization of human embryonic stem cells / Maisam Mitalipova and Gail Palmarini -- Routine culture and differentiation of human embryonic stem cells / Jim McWhir, Davina Wojtacha, and Alison Thomson -- Culture of human embryonic stem cells on human and mouse feeder cells / Gautam Dravid, Holly Hammond, and Linzhao Cheng -- Maintenance of human embryonic stem cells in animal serum- and feeder layer- free culture conditions / Michal Amit and Joseph Itskovitz-Eldor -- Manipulation of self-renewal in human embryonic stem cells through a novel pharmacological GSK-3 inhibitor / Noboru Sato and Ali H. Brivanlou -- Derivation of human feeders for prolonged support of human embryonic stem cells / Chui-Yee Fong and Ariff Bongso -- Transplantation of human embryonic stem cells to the chick embryo / Ronald S. Goldstein -- Derivation and characterization of neuronal precursors and dopaminergic neurons from human embryonic stem cells in vitro / Melissa Carpenter ... [et al.] -- In vitro differentiation of neural precursors from human embryonic stem cells / Xue-Jun Li and Su-Chun Zhang -- Derivation and characterization of hematopoietic cells from human embryonic stem cells / Lisheng Wang ... [et al.] -- Retroviral transduction of hematopoietic progenitors derived from human embryonic stem cells / Pablo Menendez ... [et al.] -- Genetic manipulation of human embryonic stem cells by transfection / Rachel Eiges -- Designing, testing, and validating a microarray for stem cell characterization / Yongquan Luo ... [et al.] -- Microarray approach to identify the signaling network responsible for self-renewal of human embryonic stem cells / Noboru Sato and Ali H. Brivanlou -- Massively parallel signature sequencing / Daixing Zhou ... [et al.] -- Confrontation cultures of embryonic stem cells with multicellular tumor spheroids to study tumor-induced angiogenesis / Maria Wartenberg ... [et al.] -- A novel experimental platform for investigating cancer growth and anti-cancer therapy in a human tissue microenvironment derived from human embryonic stem cells / Maty Tzukerman and Karl L. Skorecki -- The analysis of mitochondria and mitochondrial DNA in human embryonic stem cells / Justin C. St. John ... [et al.].
  • Human stem cell manual. 2nd ed. 2012, ScienceDirect
    This manual is a comprehensive compilation of "methods that work" for deriving, characterizing, and differentiating hPSCs, written by the researchers who developed and tested the methods and use them every day in their laboratories. The manual is much more than a collection of recipes; it is intended to spark the interest of scientists in areas of stem cell biology that they may not have considered to be important to their work. The second edition of the Human Stem Cell Manual is an extraordinary laboratory guide for both experienced stem cell researchers and those just beginning to use stem cells in their work. Offers a comprehensive guide for medical and biology researchers who want to use stem cells for basic research, disease modeling, drug development, and cell therapy applications.Provides a cohesive global view of the current state of stem cell research, with chapters written by pioneering stem cell researchers in Asia, Europe, and North America.Includes new chapters devoted to recently developed methods, such as iPSC technology, written by the scientists who made these breakthroughs.
  • Association between cancer and "acid mucopolysaccharides" : an old concept comes of age, finally -- Hyaluronan-CD44 interactions and chemoresistance in cancer cells -- Growth factor regulation of hyaluronan deposition in malignancies -- Hyaluronan binding protein 1 (HABP1/p32/gClqR) : a new perspective in tumor development -- CD44 meets Merlin and Ezrin : their interplay mediates the pro-tumor activity of CD44 and tumor-suppressing effect of Merlin -- Hyaluronan-mediated CD44 interaction with receptor and non-receptor kinases promotes oncogenic signaling, cytoskeleton activation, and tumor progression -- Adhesion and penetration : two sides of CD44 signal transduction cascades in the context of cancer cell metastasis -- Involvement of CD44, a molecule with a thousand faces, in cancer dissemination -- RHAMM/HMMR : an itinerant and multifunctional hyaluronan binding protein that modifies CD44 signaling and mitotic spindle formation -- Altered hyaluronan biosynthesis in cancer progression --Hyaluronidase : both a tumor promoter and suppressor -- The hyaluronidases in cancer biology -- Hyaluronan fragments : informational polymers commandeered by cancers -- Hyaluronan in human tumors : importance of stromal and cancer cell-associated hyaluronan -- The oncofetal paradigm revisited : MSF and HA as contextual drivers of cancer progression -- Hyaluronan synthesis and turnover in prostate cancer -- Role of hyaluronan in melanoma progression -- Role of hyaluronan metabolism in the initiation, invasion, and metastasis of breast cancer -- Clinical use of hyaluronidase in combination cancer chemotherapy : a historic perspective -- Exploring the hyaluronan:CD44 interaction for cancer therapy -- Hyaluronidase-2 and its role as a cell-entry receptor for sheep retroviruses that cause contagious respiratory tract cancers.
  • Pt. B ScienceDirect
    Pt. C ScienceDirect
  • Adult neurogenesis has been questioned for many years. In the early 1900s, a dogma was established that denied new neuron formation in the adult brain. Adult neural stem cells are undifferentiated cells that are present in the adult brain and are capable of dividing and differentiating into glia and new neurons.
  • The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.
  • Recent years have witnessed numerous advances in stem cell research that have suggested novel strategies for the treatment of the chronic and regenerative diseases that pose a growing challenge to the provision of healthcare in the 21<sup>st</sup> century. Nevertheless, there is little doubt that related disciplines have failed to keep pace with such developments, of which the immunology of transplant rejection is perhaps the most relevant to the nascent field of regenerative medicine. Indeed, given that after decades of research into the mechanisms of organ allograft rejection, we remain wholly dependent on immune suppression to ensure acceptance of foreign tissues, we might legitimately ask whether there is any reason why tissues differentiated from stem cells might not suffer the same fate. This volume seeks to address this issue by drawing on the principles of alloantigen recognition to assess the validity of early convictions that embryonic stem cell-derived tissues may prove invisible to the immune system of the host and the more recent belief that induced pluripotent stem cells, derived in a fully autologous manner, will circumvent the issue of immunogenicity. Having debunked such assumptions and established the magnitude of the immunological barriers to be overcome, this book then draws on the expertise of internationally-recognised laboratories around the world to provide a critical assessment of the likely success of applying strategies such as stem cell banking, silencing of genes that confer immunogenicity, and the induction of transplantation tolerance to overcoming the immunological barriers in the future. Indeed, it is only through reaching a consensus in the field that enduring solutions to such an intractable problem may ultimately emerge.

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