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  • Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species-including mice, sheep, cattle, and non-mammals-is considered as well.
  • 2011 ClinicalKey
    Chapter 1. Molecular Organization of Cells / Jon D. Ahlstrom -- Chapter 2. Cell-ECM Interactions in Repair and Regeneration / M. Petreaca, M. Martins-Green -- Chapter 3. Mechanisms of Blastema Formation in Regenerating Amphibian Limbs / David L. Stocum, Nandini Rao -- Chapter 4. The Molecular Circuitry Underlying Pluripotency in Embryonic Stem Cells and iPS Cells / Harvir Singh, Ali H. Brivanlou -- Chapter 5. How Cells Change their Phenotype / Caroline Beth Sangan, David Tosh -- Chapter 6. Scarless Wound Healing / Allison Nauta, Barrett Larson, Michael T. Longaker, H. Peter Lorenz -- Chapter 7. Somatic Cloning and Epigenetic Reprogramming in Mammals / Heiner Niemann, Wilfried A. Kues, Andrea Lucas-Hahn, Joseph W. Carnwath -- Chapter 8. Engineered Proteins for Controlling Gene Expression / Charles A. Gersbach -- Chapter 9. Genetic Approaches in Human Embryonic Stem Cells and their Derivatives: Prospects for Regenerative Medicine / Junfeng Ji, Bonan Zhong, Mickie Bhatia -- Chapter 10. Embryonic Stem Cells: Derivation and Properties / Junying Yu, James A. Thomson -- Chapter 11. Alternative Sources of Human Embryonic Stem Cells / Svetlana Gavrilov, Virginia E. Papaioannou, Donald W. Landry -- Chapter 12. Stem Cells from Amniotic Fluid / Mara Cananzi, Anthony Atala, Paolo de Coppi -- Chapter 13. Induced Pluripotent Stem Cells / Keisuke Okita, Shinya Yamanaka -- Chapter 14. MSCs in Regenerative Medicine / Arnold I. Caplan -- Chapter 15. Multipotent Adult Progenitor Cells / Philip Roelandt, Catherine M. Verfaillie -- Chapter 16. Hematopoietic Stem Cell Properties, Markers, and Therapeutics / Kuanyin K. Lin, Grant A. Challen, Margaret A. Goodell -- Chapter 17. Mesenchymal Stem Cells / Zulma Gazit, Gadi Pelled, Dima Sheyn, Nadav Kimelman, Dan Gazit -- Chapter 18. Cell Therapy of Liver Disease: From Hepatocytes to Stem Cells / Stephen C. Strom, Ewa C.S. Ellis -- Chapter 19. Cardiac Stem Cells: Biology and Therapeutic Applications / Sarah Selem, Konstantinos E. Hatzistergos, Joshua M. Hare -- Chapter 20. Skeletal Muscle Stem Cells / Benjamin D. Cosgrove, Helen M. Blau -- Chapter 21. Stem Cells Derived from Fat / Adam J. Katz, Alexander F. Mericli -- Chapter 22. Peripheral Blood Stem Cells / Zhan Wang, Gunter Schuch, J. Koudy Williams, Shay Soker -- Chapter 23. Islet Cell Therapy and Pancreatic Stem Cells / Juan Domínguez-Bendala, Antonello Pileggi, Camillo Ricordi -- Chapter 24. Regenerative Medicine for Diseases of the Retina / Deepak A. Lamba, Thomas A. Reh -- Chapter 25. Somatic Cells: Growth and Expansion Potential of T Lymphocytes / Rita B. Effros -- Chapter 26. Mechanical Determinants of Tissue Development / Jonathan A. Kluge, Gary G. Leisk, David L. Kaplan -- Chapter 27. Morphogenesis of Bone, Morphogenetic Proteins, and Regenerative Medicine / A.H. Reddi -- Chapter 28. Physical Stress as a Factor in Tissue Growth and Remodeling / Joel D. Boerckel, Christopher V. Gemmiti, Yash M. Kolambkar, Blaise D. Porter, Robert E. Guldberg -- Chapter 29. Intelligent Surfaces for Cell-Sheet Engineering / Takanori Iwata, Masayuki Yamato, Teruo Okano -- Chapter 30. Applications of Nanotechnology for Regenerative Medicine / Benjamin S. Harrison, Sirinrath Sirivisoot -- Chapter 31. Design Principles in Biomaterials and Scaffolds / Hyukjin Lee, Hyun Jung Chung, Tae Gwan Park -- Chapter 32. Natural Origin Materials for Bone Tissue Engineering - Properties, Processing, and Performance / V.M. Correlo, J.M. Oliveira, J.F. Mano, N.M. Neves, R.L. Reis -- Chapter 33. Synthetic Polymers / M.C. Hacker, A.G. Mikos -- Chapter 34. Biological Scaffolds for Regenerative Medicine / Alexander Huber, Stephen F. Badylak -- Chapter 35. Hydrogels in Regenerative Medicine / Justin M. Saul, David F. Williams -- Chapter 36. Surface Modification of Biomaterials / Andrés J. García -- Chapter 37. Histogenesis in Three-dimensional Scaffolds / Melissa K. McHale, Nicole M. Bergmann, Jennifer L. West -- Chapter 38. Biocompatibility and Bioresponse to Biomaterials / James M. Anderson -- Chapter 39. Designing Tunable Artificial Matrices for Stem Cell Culture / Elizabeth F. Irwin, Jacob F. Pollock, David V. Schaffer, Kevin E. Healy -- Chapter 40. Biomineralization and Bone Regeneration / Jiang Hu, Xiaohua Liu, Peter X. Ma -- Chapter 41. Cell Therapy for Blood Substitutes / Shi-Jiang Lu, Qiang Feng, Feng Li, Erin A. Kimbrel, Robert Lanza -- Chapter 42. Articular Cartilage / Lily Jeng, Francois Ng kee Kwong, Myron Spector -- Chapter 43. Myoblast Transplantation in Skeletal Muscles / Daniel Skuk, Jacques P. Tremblay -- Chapter 44. Clinical Islet Transplantation / Juliet A. Emamaullee, Michael McCall, A.M. James Shapiro -- Chapter 45. Fetal Tissues / Ryan P. Dorin, Chester J. Koh -- Chapter 46. Engineering of Large Diameter Vessels / Masood A. Machingal, Saami K. Yazdani, George J. Christ -- Chapter 47. Engineering of Small-Diameter Vessels / Brett C. Isenberg, Chrysanthi Williams, Robert T. Tranquillo -- Chapter 48. Cardiac Tissue / Milica Radisic, Michael V. Sefton -- Chapter 49. Regenerative Medicine in the Cornea / May Griffith, Per Fagerholm, Neil Lagali, Malcolm A. Latorre, Joanne Hackett, Heather Sheardown -- Chapter 50. Alimentary Tract / Richard M. Day -- Chapter 51. Extracorporeal Renal Replacement / Kimberly A. Johnston, H. David Humes -- Chapter 52. Tissue Engineering of the Reproductive System / Stefano Da Sacco, Laura Perin, Roger E. De Filippo -- Chapter 53. Cartilage Tissue Engineering / Qiongyu Guo, Jennifer H. Elisseeff -- Chapter 54. Functional Tissue Engineering of Ligament and Tendon Injuries / Savio L.-Y. Woo, Alejandro J. Almarza, Sinan Karaoglu, Rui Liang, Matthew B. Fisher -- Chapter 55. Central Nervous System / Brian G. Ballios, M. Douglas Baumann, Michael J. Cooke, Molly S. Shoichet -- Chapter 56. Peripheral Nerve Regeneration / Mahesh C. Dodla, Vivek J. Mukhatyar, Ravi V. Bellamkonda -- Chapter 57. Tissue Engineering of Skin / Fiona Wood -- Chapter 58. Regenerative Medicine of the Respiratory Tract / Martin A. Birchall, Sam Janes, Paolo Macchiarini -- Chapter 59. The Digit: Engineering of Phalanges and Small Joints / Makoto Komura, Jaehyun Kim, Anthony Atala, James J. Yoo, Sang Jin Lee -- Chapter 60. Intracorporeal Kidney Support / Jae Hyun Bae, Tamer Aboushwareb, Anthony Atala, James J. Yoo -- Chapter 61. Ethical Considerations / Ronald M. Green -- Chapter 62. US Stem Cell Research Policy / Josephine Johnston -- Chapter 63. Overview of the FDA Regulatory Process / Kevin J. Whittlesey, Mark H. Lee, Jiyoung M. Dang, Maegen Colehour, Judith Arcidiacono, Ellen Lazarus, David S. Kaplan, Donald Fink, Charles N. Durfor, Ashok Batra, Stephen L. Hilbert, Deborah Lavoie Grayeski, Richard McFarland, Celia Witten.
  • Harvest of a therapeutic protein product from high cell density fermentation broths : principles and case study / Elisabeth Russell, Alice Wang, and Anurag S. Rathore -- Expanded bed adsorption for capture from crude solution / Alan Sonnenfeld and Jorg Thommes -- Product recovery by high-gradient magnetic fishing / Matthias Franzreb ... [et al.] -- Protein refolding and scale up / Cynthia Cowgill, Asuman G. Ozturk, and Richard St. John -- Bulk protein crystallization, principles and methods / Mark R. Etzel -- Modes of preparative chromatography / Abhinav A. Shukla and Yinges Yigzaw -- Screening of chromatographic stationary phases / Abhinav A. Shukla and Xuejun Sean Han -- A priori prediction of chromatographic separations from protein structure data / Asif Ladiwala, Curt M. Breneman, and Steven M. Cramer -- Membrane chromatography : analysis of breakthrough curves and viral clearance / Mark R. Etzel and William T. Riordan -- Ultrafiltration process design and implementation / Herb Lutz and Bala Raghunath -- Virus filtration process design and implementation / Michael W. Phillips ... [et al.] -- Product recovery from transgenic sources / Chenming (Mike) Zhang and Kevin E. Van Cott -- Analytical strategy for biopharmaceutical development / Drew N. Kelner and Mahesh K. Bhalgat -- Evaluation of viral clearance in purification processes / Amitava Kundu and Karl Reindel -- Advances in viral clearance / Kurt Brorson -- Protein A affinity chromatography for capture and purification of monoclonal antibodies and Fc-fusion proteins: practical considerations for process development / Sanchayita Ghose, Thomas McNerney, and Brian Hubbard -- Polishing methods for monoclonal IgG purification / Pete Gagnon -- Making changes to a biopharmaceutical manufacturing process during development and commercial manufacturing : the REMICADE story / Peter W. Wojciechowski ... [et al.] -- Linear scale-up of ultrafiltration of high viscosity process streams / Christopher Daniels ... [et al.] -- A membrane chromatography application : a rapid, high capacity gene therapy vector purification tool / Ajay R. Lajmi, Robert Kutner, and Jakob Reiser.
  • Organic Acid and Solvent Production: Acetic, Lactic, Gluconic, Succinic, and Polyhydroxyalkanoic Acids / Palmer Rogers, Jiann-Shin Chen, Mary Jo Zidwick -- Organic Acid and Solvent Production: Butanol, Acetone, and Isopropanol; 1,3- and 1,2-Propanediol Production; and 2,3-Butanediol Production / Jiann-Shin Chen, Mary Jo Zidwick, Palmer Rogers -- Organic Acid and Solvent Production: Propionic and Butyric Acids and Ethanol / Mary Jo Zidwick, Jiann-Shin Chen, Palmer Rogers -- Amino Acid Production / Hidehiko Kumagai -- Microbial Exopolysaccharides / Avinash Mishra, Dr. Bhavanath Jha -- Bacterial Enzymes / Prof. Wim J. Quax -- Diversity and Biotechnological Applications of Prokaryotic Enzymes / Alane Beatriz Vermelho, Eliane Ferreira Noronha, Edivaldo Ximenes Ferreira Filho -- Bacteria in Food and Beverage Production / Dr. Michael P. Doyle, Larry R. Steenson, Jianghong Meng -- Bacterial Pharmaceutical Products / Giancarlo Lancini, Dr. Arnold L. Demain -- Biosurfactants / Dr. Eugene Rosenberg, Eliora Z. Ron -- Bioremediation / Ronald L. Crawford, Dr. Eugene Rosenberg -- Biodeterioration / Ji-Dong Gu, Ralph Mitchell -- Microbial Biofilms / Dirk De Beer, Paul Stoodley -- Biofuels / Stefano Freguia, Bernardino Virdis, Dr. Korneel Rabaey -- The Metabolic Pathways of Biodegradation / Lawrence P. Wackett.
  • The book entitled "Prospects in Bioscience: Addressing the issues" is a collection of selected research papers presented at the International Conference on Advances in Biological Sciences (ICABS) organized by the Department of Biotechnology and Microbiology and the Inter University Centre for Bioscience, Kannur University, Kerala, India. ICABS witnessed a unique spectrum of Scientific Programmes on the most recent and exciting developments in modern biology. The conference displayed the numerous breakthroughs and significant developments in the important areas of modern biology and their relevance to the welfare of global society. The Book contains 50 well written chapters, each one discussing scientifically organized findings of original research work done in reputed laboratories. Needless to say, they deal with advances in various disciplines of modern biology including Cell and Molecular Biology, Structural Biology, Industrial and Environmental Biotechnology, Food and Agricultural Biotechnology and Medical Biotechnology. As the title rightly indicates, the chapters project the prospects in the respective areas and the issues in them. Specific issues discussed in the book includes development of transgenic plants, bioremediation of toxic industrial effluents, biotransformation for novel antibiotics, biofertilizer development, molecular drug designing and structure elucidation, molecular identification of pathogens, production of anti microbials, biocontrol agents and bioactive molecules, cancer biology, plant breeding and hybrid seed production etc. The book with its contents spreading across the vast arena of modern biology is expected to cater to the need of researchers, technologists and students.
  • Protein engineering 2009
    Understanding enzyme mechanism through protein chimeragenesis / N.M. Goodey and S.J. Benkovic -- Chemical protein engineering : synthetic and semisynthetic peptides and proteins / L. Merkel, L. Moroder, and N. Budisa -- Native chemical ligation: Semisynthesis of post-translationally modified proteins and biological probes / E. Vogel Taylor and B. Imperiali -- Chemical methods for mimicking post-translational modifications / S.I. van Kasteren, P. Garnier and B.G. Davis -- Noncanonical amino acids in protein science and engineering / K.E. Beatty and D.A. Tirrell -- Fidelity mechanisms of the aminoacyl-tRNA synthetases / A.P. Mascarenhas ... [et al.] -- Specialized components of the translational machinery for unnatural amino acid mutagenesis : tRNAs, aminoacyl-tRNA synthetases, and ribosomes / C. Köhrer and U.L. RajBhandary -- In vivo studies of receptors and ion channels with unnatural amino acids / D.A. Dougherty -- Synthesis of modified proteins using misacylated tRNAs / S.M. Hecht -- Cell-free synthesis of proteins with unnatural amino acids. The pure system and expansion of the genetic code / I. Hirao, T. Kanamori and T. Ueda -- Engineering nucleobases and polymerases for an expanded genetic alphabet / A.M. Leconte and F.E. Romesberg -- Understanding membrane proteins. How to design inhibitors of transmembrane protein-protein interactions / J.S. Slusky, H. Yin and W.F. DeGrado.
  • Proteomics for biomarker discovery 2013
    Springer Protocols
    Affinity depletion of plasma and serum for mass spectrometry-based proteome analysis / Julian A.J. Jaros ... [et al.] -- Tissue sample preparation for biomarker discovery / Yoshiyuki Suehara, Daisuke Kubota, and Tsuyoshi Saito -- Subcellular fractionation for identification of biomarkers : serial detergent extraction by subcellular accessibility and solubility / Sun-II Hwang and David K. Han -- Analysis of secreted proteins / Valeria Severino, Annarita Farina, and Angela Chambery -- Preparation of human cerebrospinal fluid for proteomics biomarker analysis / Timothy J. Waybright -- Proteomic analysis of frozen tissue samples using laser capture microdissection / Sumana Mukherjee ... [et al.] -- Use of formalin-fixed, paraffin-embedded tissue for proteomic biomarker discovery / David B. Krizman and Jon Burrows -- Phosphopeptide enrichment using offline titanium dioxide columns for phosphoproteomics / Li-Rong Yu and Timothy Veenstra -- iTRAQ-labeling for biomarker discovery / Leroi V. DeSouza, Sébastien N. Voisin, and K.W. Michael Siu -- Analysis of glycoproteins for biomarker discovery / Jintang He ... [et al.] -- SILAC in biomarker discovery / Benjamin C. Orsburn -- Trypsin-mediated 18O/16O labeling for biomarker discovery / Xiaoying Ye ... [et al.] -- Two-dimensional SDS-PAGE fractionation of biological samples for biomarker discovery / Thierry Rabilloud and Sarah Triboulet -- Informatics of protein and posttranslational modification detection via shotgun proteomics / Jerry D. Holman, Surendra Dasari, and David L. Tabb -- Quantitation of met tyrosine phosphorylation using MRM-MS / Zhaojing Meng -- Preparation of human serum for prolactin measurement by multiple reaction monitoring mass spectrometry / Timothy J. Waybright ... [et al.] -- Label-free quantitative shotgun proteomics using normalized spectral abundance factors / Karlie A. Neilson ... [et al.] -- Employment of complementary dissociation techniques for body fluid characterization and biomarker discovery / David M. Good and Dorothea Rutishauser -- Phosphopeptide microarrays for comparative proteomic profiling of cellular lysates / Liqian Gao ... [et al.] -- Tissue preparation for MALDI-MS imaging of protein and peptides / Simona Colantonio and Roberta M. Smith -- Plant proteogenomics : from protein extraction to improved gene predictions / Brett Chapman ... [et al.] -- Label-free differential analysis of murine postsynaptic densities / Scott P. Goulding, Michael J. MacCoss, and Christine C. Wu -- Fractionation of peptides by strong cation-exchange liquid chromatography / King C. Chan and Haleem J. Issaq.
  • The drug discovery business to date -- The drug discovery business to come -- Industrial considerations -- how things get done : the project team -- Project considerations -- Hit generation -- Turning hits into drugs -- Initial properties -- ADME and PK properties -- Toxicity related properties -- A career in drug discovery research.
  • 1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
  • RNAi technology 2011
    "RNA interference (RNAi) is a system within living cells that helps to control active genes and their activity level. Two types of small RNA molecules--microRNA (miRNA) and small interfering RNA (siRNA)--are central to RNA interference. The discovery of RNAi was preceded first by observations of transcriptional inhibition by antisense RNA expressed in transgenic plants and more directly by reports of unexpected outcomes in experiments performed by plant scientists in the U.S. and The Netherlands in the early 1990s. RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals."--Provided by publisher.
  • Signal and image analysis techniques are becoming more widely used in biomedical and life science applications. With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to some of the applications. It can be used by those both at graduate and specialist levels.
  • pt. 1. Stem cell biology -- pt. 2. Epigenetic and microRNA regulation in stem cells -- pt. 3. Stem cells for therapeutic applications -- pt. 4. Nuclear reprogramming and induced pluripotent stem cells -- pt. 5. Tissue engineering -- pt. 6. Regenerative medicine.
  • pt. 1. Defining, isolating, and characterizing various stem and progenitor cell populations for neovascularization -- pt. 2. In vitro studies for angiogenesis, vasculogenesis, and arteriogenesis -- pt. 3. Stem cell mobilization strategies -- pt. 4. Stem cell transplantation strategies.
  • Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed, and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis, and Poland syndrome. In addition, potential risks and complications are identified. Stem Cells in Aesthetic Procedures: Art, Science, and Clinical Techniques is completely up to date and has been written by leading experts in the field. It will be an invaluable source of information for students, beginners, and experienced surgeons in the fields of plastic surgery, general surgery, cosmetic surgery, facial plastic surgery, otolaryngology, ophthalmology, and oral maxillofacial surgery.
  • Derivation and manipulation of murine embryonic stem cells / Alexander Meissner, Sarah Eminli, and Rudolf Jaenisch -- Patterning mouse and human embryonic stem cells using micro-contact printing / Raheem Peerani ... [et al.] -- Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi / Asmin Tulpule and George Q. Daley -- Measurement of cell-penetrating peptide-mediated transduction of adult hematopoietic stem cells / Aziza P. Manceur and Julie Audet -- Stem cell sources for regenerative medicine / Ali M. Riazi, Sarah Y. Kwon, and William L. Stanford -- Investigating the interactions between haemopoietic stem cells and their niche : methods for the analysis of stem cell homing and distribution within the marrow following transplantation / Brenda Williams and Susan K. Nilsson -- Ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells / Valérie Cortin, Nicolas Pineault, and Alain Garnier -- Ex vivo generation of human red blood cells : a new advance in stem cell engineering / Luc Douay and Marie-Catherine Giarratana -- Isolation and manipulation of mammalian neural stem cells in vitro / Claudio Giachino, Onur Basak, and Verdon Taylor -- Isolation, expansion, and differentiation of mouse skin-derived precursors / Karl J.L. Fernandes and Freda D. Miller -- Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord / Hynek Wichterle, Mirza Peljto, and Stephane Nedelec -- Transplantation of neural stem/progenitor cells into developing and adult CNS / Tong Zheng ... [et al.] -- Transplantation of embrynic stem cell-derived dopaminergic neurons in MPTP-treated monkeys / Jun Takahashi, Yasushi Takagi, and Hidemoto Saiki -- Isolation and culture of epithelial stem cells / Jonathan A. Nowak and Elaine Fuchs -- Regeneration of skin and cornea by tissue engineering / Danielle Larouche ... [et al.] -- Prospective isolation of mesenchymal stem cells from mouse compact bone / Brenton J. Short, Nathalie Brouard, and Paul J. Simmons -- Isolation, propagation, and characterization of human umbilical cord perivascular cells (HUCPVCs) / Rahul Sarugaser ... [et al.] -- Bone marrow-derived mesenchymal stem cells : isolation, expansion, characterization, viral transduction, and production of conditioned medium / Massimilano Gnecchi and Luis G. Melo -- Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells / Vasily Shinin, Barbara Gayraud-Morel, and Shahragim Tajbakhsh -- Isolation and grafting of single muscle fibres / Charlotte A. Collins and Peter S. Zammit -- Differentiation and dynamic analysis of primitive vessels from embryonic stem cells / Gefei Zeng and Victoria L. Bautch -- Derivation of contractile smooth muscle cells from embryonic stem cells / Sanjay Sinha, Mark H. Hoofnagle, and Gary K. Owens -- Islet-derived progenitors as a source of in vitro islet regeneration / Stephen Hanley and Lawrence Rosenberg -- Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers / Thomas D. Shupe ... [et al.] -- Reprogramming of liver to pancreas / Shifaan Thowfeequ ... [et al.]
  • Technology is essential to the delivery of health care but it is still only a tool that needs to be deployed wisely to ensure beneficial outcomes at reasonable costs. Among various categories of health technology, medical equipment has the unique distinction of requiring both high initial investments and costly maintenance during its entire useful life. This characteristic does not, however, imply that medical equipment is more costly than other categories, provided that it is managed properly. The foundation of a sound technology management process is the planning and acquisition of equipment, collectively called technology incorporation. This lecture presents a rational, strategic process for technology incorporation based on experience, some successful and many unsuccessful, accumulated in industrialized and developing countries over the last three decades. The planning step is focused on establishing a Technology Incorporation Plan (TIP) using data collected from an audit of existing technology, evaluating needs, impacts, costs, and benefits, and consolidating the information collected for decision making. The acquisition step implements TIP by selecting equipment based on technical, regulatory, financial, and supplier considerations, and procuring it using one of the multiple forms of purchasing or agreements with suppliers. This incorporation process is generic enough to be used, with suitable adaptations, for a wide variety of health organizations with different sizes and acuity levels, ranging from health clinics to community hospitals to major teaching hospitals and even to entire health systems. Such a broadly applicable process is possible because it is based on a conceptual framework composed of in-depth analysis of the basic principles that govern each stage of technology lifecycle. Using this incorporation process, successful TIPs have been created and implemented, thereby contributing to the improvement of healthcare services and limiting the associated expenses.
  • Introduction / Markus Schmidt -- That Was the Synthetic Biology That Was / Luis Campos -- An Introduction to Synthetic Biology / Carolyn M.C. Lam, Miguel Godinho and Vítor A.P. Martins dos Santos -- Computational Design in Synthetic Biology / Maria Suarez, Guillermo Rodrigo, Javier Carrera and Alfonso Jaramillo -- The Ethics of Synthetic Biology: Outlining the Agenda / Anna Deplazes, Agomoni Ganguli-Mitra and Nikola Biller-Andorno -- Do I Understand What I Can Create? Biosafety Issues in Synthetic Biology / Markus Schmidt -- Security Issues Related to Synthetic Biology Between Threat Perceptions and Governance Options / Alexander Kelle -- The Intellectual Commons and Property in Synthetic Biology / Kenneth A. Oye and Rachel Wellhausen -- Governing Synthetic Biology: Processes and Outcomes / Joyce Tait -- Synthetic Biology and the Role of Civil Society Organizations Shaping the Agenda and Arena of the Public Debate / Dirk Stemerding, Huib de Vriend, Bart Walhout and Rinie van Est -- Summary and Conclusions / Alexander Kelle.
  • Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms. Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomesHighlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications. Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.
  • Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • Preface / Christoph Wittmann and Sang Yup Lee -- 1. Genome-scale network modeling / Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth, and Bernhard Ø. Palsson -- 2. Kinetic modeling of metabolic networks / Daniel C. Zielinski and Bernhard Ø. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis / Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, and Hiroshi Shimizu -- 4. Technologies for bio-systems engineering / Sonja Billerbeck, Sven Dietz, Gaspar Morgado, and Sven Panke -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals / Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, and Sang Yup Lee -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels / Judith Becker, Stefanie Kind, and Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites / Eleftherios T. Papoutsakis and Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum / I. Emrah Nikerel, Peter J.T. Verheijen, Walter M. van Gulik, and Joseph J. Heijnen -- 9. Bridging omics technologies with synthetic biology in yeast industrial biotechnology / António Roldão, Il-Kwon Kim, and Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering / Tomohisa Hasunuma, Fumio Matsuda, and Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism / Paulo A. Gameiro, Christian M. Metallo, and Gregory Stephanopoulos.
  • Applied groundwork for a practical moral code. Introduction ; Definitions ; Professional moral codes ; USDA study : methodology and results ; Formalization and evaluation of the USDA study's moral codes ; Formalization of the combination moral code ; Problems for the combination moral code ; Conclusion -- A practical moral code. Introduction ; Utilitarianism ; What is a reasonable person? ; RPU's benefits ; Respecting persons ; Working toward a plausible distributive/social justice principle ; The moral paradigm test ; Conclusion -- Are transgenic organisms, biotechnology, and technology unnatural? Introduction ; The unnatural is unethical argument ; The weak definitions ; A "playing God" argument ; More complex meanings of the unnatural ; Arguments from evolution ; Conclusion -- A natural theory of value. Introduction ; Naturalness as sacredness ; Beginning an axiology ; The benefit of the doubt principle ; Intrinsically valuable things and their rankings ; Is nature or the biosphere alive? ; Arguments against nature's intrinsic value ; Conclusion -- Applying PMC to a few transgenic technology issues. Introduction ; The practical moral code again ; Transgenics and RPU ; Transgenics and QCI ; Legal/moral questions ; Conclusion.
  • Part 1. GENERAL -- History of Microsurgery / Yoshikazu Ikuta -- History of Telesurgery / James Wall and Jacques Marescaux -- Description of Robots / Jesse Creed Selber -- Instruments / Sijo Joseph Parekatti and Michael Moran -- Robot Installation in Telemicrosurgery / Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux -- Part 2. TRAINING -- Earthworms / Gustavo Mantovani Ruggiero -- Vessels / Joo-Yup Lee and Alexander Y. Shin -- Nerves / Stacey H. Berner -- Part 3. EXPERIMENTAL RESEARCH -- Free Tissue Transfer / Stacey H. Berner -- Tele-endomicrosurgery / Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux -- Brachial Plexus Repair / Gustavo Mantovani Ruggiero and Philippe Liverneaux -- Tendon Transfer / Michael S. Bednar -- Part 4. CLINICAL APPLICATIONS -- Nerve Entrapment / Jose Carlos Garcia Jr. -- Nerve Repair / Stacey H. Berner -- Brachial Plexus / Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux -- Skin Flaps / Thomas Lauwers, Tom Van Mulken and Darren Booi -- Muscle Flaps / Jesse Creed Selber and John C. Pedersen -- Head and Neck / Jesse Creed Selber -- Urology / Sijo Joseph Parekattil -- Part 5. PERSPECTIVES -- Supermicrosurgery / Takeshi Todokoro and Isao Koshima -- Network / Catherine Jane Mohr.
  • Highlights and trends in cell encapsulation / Gorka Orive and José Luis Pedraz -- Biomaterials in cell microencapsulation / Edorta Santos ... [et al.] -- Development of subsieve size capsules and application to cell therapy / Shinji Sakai and Koei Kawakami -- Regulatory considerations in application of encapsulated cell therapies / J. van Zanten and Paul de Vos -- Treatment of diabetes with encapsulated islets / Paul de Vos, Milica Spasojevic, and Marijke M. Faas -- Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules / Ainhoa Murua ... [et al.] -- Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering, and cell therapy / Zun Chang Liu and Thomas Ming Swi Chang -- Microencapsulated choroid plexus epithelial cell transplants for repair of the brain / Christopher G. Thanos, Briannan Bintz, and Dwaine F. Emerich -- Therapeutic application of cell microencapsulation in cancer / Brian Salmons and Walter H. Gunzburg -- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery / Adam Mendelsohn and Tejal Desai -- Cell microencapsulation / Grace J. Lim ... [et al.] -- Commercial applicability of cell microancapsulation : a review of intellectual property rights / Stephan M. Meier.
  • "This book bridges the gap between nanotechnology and regenerative medicine to facilitate their transition from lab to the clinic. It compiles important aspects of the basic science and fundamental principles to current nanotechnological innovations in biomaterials, cell, tissue, and organ engineering, and their clinical relevance, as well as future trends in regenerative medicine. It is intended for a wide audience including students, researchers, professors, and industrial experts working in the tields of biomaterial science and engineering, nanoscience and nanotechnology, bioengineering, cell biology, biomedical sciences, tissue engineering, and nanomedicine"--Provided by publisher.
  • BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
  • pt. 1. Stem cells -- pt. 2. Biomaterials and the extracellular environment -- pt. 3. Engineered tissue -- pt. 4. Synthetic organs -- pt. 5. Immune response -- pt. 6. Animal models.
  • Applications of tissue microarray technology -- Quality aspects of TMA analysis -- Representativity of TMA studies -- Recipient block TMA technique -- Protocol for constructing tissue arrays by cutting edge matrix assembly -- Hypodermic needle without recipient paraffin block technique -- Resin technologies : construction and staining of resin TMA's -- Tissue microarrays from frozen tissues-OCT technique -- An alternative technology to prepare tissue microarray using frozen tissue samples -- Building "tissue" microarrays from suspension cells -- Tissue microarrays from biopsy specimens -- Immunohistochemical analysis of tissue microarrays -- DNA copy number analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization -- Automated analysis of tissue microarrays -- Digital microscopy for boosting database integration and analysis in TMA studies -- From gene to clinic : TMA-based clinical validation of molecular markers in prostate cancer
  • Ch. 1. An introduction to VNPs and nanotechnology -- ch. 2. Overview of the manifold VNPs used in nanotechnology -- ch. 3. Production of VNPs, VLPs, and chimeras -- ch. 4. The art of bioconjugation : functionalization of VNPs -- ch. 5. Encapsulating materials within VNPs -- ch. 6. VNPs as templates for materials synthesis -- ch. 7. Playing "nano-lego" : VNPs as building blocks for the construction of multi-dimensional arrays -- ch. 8. VNPs as tools for nanomedicine -- ch. 9. Summary and outlook.
  • Chemical modification of viruses and virus-like particles / E. Strable, M.G. Finn -- Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology / N.F. Steinmetz, T. Lin, G.P. Lomonossoff, J.E. Johnson -- Hybrid assembly of CPMV viruses and surface characteristics of different mutants / N.G. Portney, G. Destito, M. Manchester, M. Ozkan -- A library of protein cage architectures as nanomaterials / M.L. Flenniken ... [et al.] -- Biomedical nanotechnology using virus-based nanoparticles / G. Destito, A. Schneemann, M. Manchester -- Tumor targeting using canine parvovirus nanoparticles / P. Singh.

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