Books by Subject

Biotechnology

  • Digital
    edited by Arun K. Shukla.
    ScienceDirectPt. A
    ScienceDirectPt. B
  • Digital
    edited Maurizio Lambardi, Elif Aylin Ozudogru, Shri Mohan Jain.
    Springer Protocols2013
    Micropropagation of pear (Pyrus sp.) / Barbara M. Reed [and others] -- In vitro propagation of jojoba / Berta E. Llorente and Nancy M. Apóstolo -- In vitro propagation of olive (Olea europaea L.) by nodal segmentation of elongated shoots / Maurizio Lambardi, Elif Aylin Ozudogru, and Romano Roncasaglia -- Micropropagation systems of feijoa (Acca sellowiana (O. Berg) burret) / Miguel Pedro Guerra [and others] -- Micropropagation of Vaccinium sp. by in vitro axillary shoot proliferation / Wojciech Litwinczuk -- In vitro propagation of peanut (Arachis hypogaea L.) by shoot tip culture / Elif Aylin Ozudogru, Ergun Kaya, and Maurizio Lambardi -- In vitro propagation of persimmon (Diospyros kaki Thunb.) / Edgardo Giordani, Mar Naval, and Carla Benelli -- Micropropagation of Citrus spp. by organogenesis and somatic embryogenesis / Benedetta Chiancone and Maria Antonietta Germanà -- Micropropagation of Prunus species relevant to cherry fruit production / Philippe Druart -- Micropropagation of peach rootstocks and cultivars / Ildikó Balla and Lucienne Mansvelt -- Micropropagation of Rubus and Ribes spp / Ewa Dziedzic and Joanna Jagła -- Somatic embryogenesis for efficient micropropagation of guava (Psidium guajava L.) / Nasim Akhtar -- Micropropagation of chokeberry by in vitro axillary shoot proliferation / Wojciech Litwińczuk -- Micropropagation of Lavandula spp / Sandra Gonçalves and Anabela Romano -- In vitro propagation of Acacia mangium and A. mangium? A. auriculiformis / Olivier Monteuuis, Antoine Galiana, and Doreen Goh -- In vitro propagation of ash (Fraxinus excelsior L.) by somatic embryogenesis / Maurizio Capuana -- Micropropagation of paradise tree (Melia azedarach) by in vitro culture of axillary buds / Luis A. Mroginski and Hebe Y. Rey -- In Vitro Propagation of Hydrangea spp / Barbara Ruffoni, Ermanno Sacco, and Marco Savona -- In vitro propagation of fraser photinia using Azospirillum-mediated root development / Berta E. Llorente and Ezequiel E. Larraburu -- Micropropagation of Helleborus through axillary budding / Margherita Beruto, Serena Viglione, and Alessandro Bisignano -- Micropropagation of Cordyline terminalis / Tui Ray, Prasenjit Saha, and Satyesh C. Roy -- Micropropagation of african violet (Saintpaulia ionantha Wendl.) / Mukund Shukla [and others] -- Micropropagation of Iris sp / Sladana Jevremovic, Zoran Jeknic, and Angelina Subotic -- Micropropagation of Gerbera (Gerbera jamesonii Bolus) / Ghani Minerva and Surinder Kumar -- Micropropagation of onion (Allium cepa L.) from immature inflorescences / Pablo Marinangeli -- In vitro propagation of cauliflower using curd microexplants / Martin Kieffer and Michael P. Fuller -- Micropropagation of Asparagus by in vitro shoot culture / Nataša Štajner -- Micropropagation and cryopreservation of garlic (Allium sativum L.) / E.R. Joachim Keller and Angelika Senula -- Micropropagation of globe artichoke (Cynara cardunculus L. var. scolymus) / Giovanni Iapichino -- In vitro rejuvenation of woody species / Paul E. Read and Christina M. Bavougian -- Encapsulation of in vitro- derived explants : an innovative tool for nurseries / Alvaro Standardi and Maurizio Micheli -- Thermotherapy, chemotherapy, and meristem culture in banana / Ludivine Lassois [and others] -- Agrobacterium-mediated genetic transformation of pineapple (Ananas comosus L., Merr.) / Minal Mhatre -- Protocol for inducing flower color somaclonal variation in Torenia (Torenia fournieri Lind.) / Duong Tan Nhut [and others] -- Production of pathogen-free horticultural crops by cryotherapy of in vitro-grown shoot tips / Chaohong Feng [and others].
  • Digital
    Rosa Margesin ... [et. al.], editors.
    Springer2008
  • Digital
    Antonella Lanati ; in collaborazione con Luigi Cavenaghi ... [et al.] ; presentazione a cura di Marina Del Bue.
    Springer2010
  • Digital
    International Commission on Radiation Units and Measurements.
    HighWire2009
  • Digital
    edited by Roberto Biassoni, Laboratorio Medicina Molecolare, Dipartimento Medicina Traslazionale, Instituto Giannina Gaslini, Genova, Italy, Alessandro Raso, Laboratorio U.O.C. Neurochirugia, Instituto Giannina Gaslini, Genova, Italy.
    Springer Protocols2014
    Twenty years of qPCR: A mature technology? -- Minimum information necessary for quantitative real-time PCR experiments -- Selection of reliable reference genes for RT-qPCR analysis -- Introduction to digital PCR -- mRNA and microRNA purity and integrity: The key to success in expression profiling -- Mediator probe PCR: Detection of real-time PCR by label-free probes and a universal fluorogenic reporter -- Absolute quantification of viral DNA: The quest for perfection -- A multiplex real-time PCR-platform integrated into automated extraction method for the rapid detection and measurement of oncogenic HPV type-specific viral DNA load from cervical samples -- Real-time PCR detection of mycoplasma pneumoniae in the diagnosis of community-acquired pneumonia -- A sensible technique to detect mollicutes impurities in human cells cultured in GMP condition -- Real-time quantification assay to monitor BCR-ABL1 transcripts in chronic myeloid leukemia -- A reliable assay for rapidly defining transplacental metastasis using quantitative PCR -- Circulating cell-free DNA in cancer -- Gene expression analysis by qPCR in clinical kidney transplantation -- Posttranscriptional regulatory networks: From expression profiling to integrative analysis of mRNA and microRNA data -- Clinical applications using digital PCR -- Developing noninvasive diagnosis for single-gene disorders: the role of digital PCR.
  • Digital
    edited by Adriana Fontes, Beate Saegesser Santos.
    Springer Protocols2014
  • Print
    Michael Nathaniel Cantor.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Robert M. Rydzewski.
    ScienceDirect2008
    The drug discovery business to date -- The drug discovery business to come -- Industrial considerations -- how things get done : the project team -- Project considerations -- Hit generation -- Turning hits into drugs -- Initial properties -- ADME and PK properties -- Toxicity related properties -- A career in drug discovery research.
  • Digital
    Hossein Baharvand, Nasser Aghdami, editors.
    Springer2013
    1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
  • Print
    George Church & Ed Regis.
    From bioplastics to H. sapiens 2.0 -- -3,800 Myr, Late Hadean : at the inorganic/organic interface -- -3,500 Myr, Archean : reading the most ancient texts and the future of living software -- -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be? -- -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum" -- -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering -- -30,000 Yr, Pleistocene Park : engineering extinct genomes -- -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto -- -100 Yr, Anthropocene : the third industrial revolution ; iGEM -- -1 Yr, Holocene : from personal genomes to immortal human components -- Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
  • Digital
    Yun Chen.
    Continuous wireless monitoring of in vivo biopotential, biochemical, and biomechanical properties has the potential to yield breakthroughs in our understanding of human health and disease. In particular, current technology does not yet allow us to do so at micron (i.e., cellular) scales. We look to create a scalable system of chronically implantable passive sensors with a wireless detection platform to individually address and continuously monitor them. Scaling down the size of resonant sensors poses significant challenges for passive wireless detection. In particular, inherently higher resonant frequencies at smaller sizes push our operation into regimes where traditional approaches fail. Two schemes based on power reflection distortion (PRD) and group delay distortion (GDD) are proposed to operate over a wide range of frequencies. They are shown to be capable of operating in high frequency regimes near and above the readout circuit self-resonance. In addition, we describe a generic finite-difference time-domain (FDTD) framework for analyzing electromagnetic (EM) wave propagation and scattering in an anatomically realistic human phantom with an inhomogeneous dispersive model. Interactions with implantable resonant sensors are studied within this framework. We demonstrate a wireless real-time monitoring system with passive, flexible sensors, which scale down to unprecedented dimensions of 1x1x0.1 cubic mm. This level of scaling is enabled by the presented GDD detection scheme, which overcomes the operating frequency limits of traditional strategies and exhibits insensitivity to lossy tissue environments. We apply this system to capture human pulse waveforms in real-time as well as to continuously monitor in vivo intracranial pressures with sensors down to 2.5x2.5x0.1 cubic mm in proof-of-concept mice studies. Furthermore, printable wireless sensor arrays are introduced and their use in concurrent spatial pressure mapping is shown. Our vision is to extend the passive sensing approach and scale the resonant sensor platform down to intracellular dimensions at the intersection of intracellular delivery limits and integrated circuit fabrication capabilities. We demonstrate a family of 3D multilayer micro-Tag (uTag) structures as a potential platform for resonant tagging and sensing at the cellular level. As a stepping stone towards chronic cellular monitoring, we demonstrate the delivery of uTags into living cells and viability of internalized uTags over a 5-day period. Looking forward, this technology creates exciting opportunities to use remote physiological monitoring as a routine part of biomedical research and patient care. In the future, we foresee that such monitoring will be possible even at the cellular level.
  • Digital/Print
    Changming Sun, Tomasz Bednarz, Tuan D. Pham, Pascal Vallotton, Dadong Wang, editors.
    Digital : Springer2015
    Print2015
    Signal and image analysis techniques are becoming more widely used in biomedical and life science applications. With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to some of the applications. It can be used by those both at graduate and specialist levels.
  • Digital
    edited by Debra J. Taxman.
    Springer Protocols2012
    What parameters to consider and which software tools to use for target selection and molecular design of small interfering RNAs / Olga Matveeva -- Methods for selecting effective siRNA target sequences using a variety of statistical and analytical techniques / Shigeru Takasaki -- Designing functional siRNA with reduced off-target effects / Yuki Naito and Kumiko Ui-Tei -- Design and screening of siRNAs against highly structured RNA targets / Neda Nasheri, John Paul Pezacki, and Selena M. Sagan -- Engineering small interfering RNAs by strategic chemical modification / Jesper B. Bramsen and Jørgen Kjems -- Design, selection, and evaluation of highly specific and functional siRNA incorporating unlocked nucleobase analogs / Narendra Vaish and Pinky Agarwal -- Design, preparation and evaluation of asymmetric small interfering RNA for specific gene silencing in mammalian cells / Chanil Chang [and others] -- Design of nuclease-resistant fork-like small interfering RNA (fsiRNA) / Elena L. Chernolovskaya and Marina A. Zenkova -- Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and MicroRNA-like targeting / Pal Sætrom -- Strategies for designing and Validating immunostimulatory siRNAs / Michael P. Gantier -- Designing efficient and specific endoribonuclease-prepared siRNAs / Vineeth Surendranath [and others] -- Short hairpin RNA-mediated gene silencing / Luke S. Lambeth and Craig A. Smith -- Design of lentivirally expressed siRNAs / Ying Poi Liu and Ben Berkhout -- Bifunctional short hairpin RNA (bi-shRNA) : design and pathway to clinical application / Donald D. Rao [and others] -- Design and chemical modification of synthetic short shRNAs as potent RNAi triggers / Anne Dallas and Brian H. Johnston -- Production and application of long dsRNA in mammalian cells / Katerina Chalupnikova, Jana Nejepinska, and Petr Svoboda -- Design of RNAi reagents for invertebrate model organisms and human disease vectors / Thomas Horn and Michael Boutros -- Construction of shRNA expression plasmids for silkworm cell lines using single-stranded DNA and Bst DNA polymerase / Hiromitsu Tanaka -- Designing effective amiRNA and multimeric amiRNA against plant viruses / Muhammad Fahim and Philip J. Larkin -- Downregulation of plant genes with miRNA-induced gene silencing / Felipe Fenselau de Felippes.
  • Digital
    edited by Visakh P. M and Olga Nazarenko.
    Wiley2017
    Soy protein : state-of-the-art, new challenges and opportunities / Visakh P. M -- Soy protein : introduction, structure and properties relationship / Visakh P. M -- Advances in soy protein-based nanocomposites / Huafeng Tian Gaiping Guo and Xiaogang Luo -- Applications of soy protein-based blends, composites, and nanocomposites / Ruann Janser Soares de Castro, Andre Ohara, Paula Okuro, Camila Utsunomia, Joelise de Alencar Figueira Angelotti, Fabiola Aliaga de Lima and Helia Harumi Sato -- Biomedical applications of soy protein / Blessing A. Aderibigbe -- Electrospinning of soy protein nanofibers : synthesis and applications / Carlos L. Salas -- Soy proteins as potential source of active peptides of nutraceutical significance / Junus Salampessy and Narsimha Reddy -- Soy protein isolate-based films / Shifeng Zhang -- Use of soy protein-based carriers for encapsulating bioactive ingredients / Zhen-Xing Tang and Jie-Yu Liang.
  • Digital
    Yanhong Shi, Dennis O. Clegg, editors.
    Springer2008
  • Digital
    Krishnarao Appasani, Raghu K. Appasani, editors ; foreword by Sir John B. Gordon.
    Springer2011
    pt. 1. Stem cell biology -- pt. 2. Epigenetic and microRNA regulation in stem cells -- pt. 3. Stem cells for therapeutic applications -- pt. 4. Nuclear reprogramming and induced pluripotent stem cells -- pt. 5. Tissue engineering -- pt. 6. Regenerative medicine.
  • Digital
    Melvin A. Shiffman, Alberto Di Giuseppe, Franco Bassetto, editors.
    Springer2014
    Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed, and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis, and Poland syndrome. In addition, potential risks and complications are identified. Stem Cells in Aesthetic Procedures: Art, Science, and Clinical Techniques is completely up to date and has been written by leading experts in the field. It will be an invaluable source of information for students, beginners, and experienced surgeons in the fields of plastic surgery, general surgery, cosmetic surgery, facial plastic surgery, otolaryngology, ophthalmology, and oral maxillofacial surgery.
  • Digital
    edited by Julie Audet and William L. Stanford.
    Springer Protocols2009
    Derivation and manipulation of murine embryonic stem cells / Alexander Meissner, Sarah Eminli, and Rudolf Jaenisch -- Patterning mouse and human embryonic stem cells using micro-contact printing / Raheem Peerani ... [et al.] -- Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi / Asmin Tulpule and George Q. Daley -- Measurement of cell-penetrating peptide-mediated transduction of adult hematopoietic stem cells / Aziza P. Manceur and Julie Audet -- Stem cell sources for regenerative medicine / Ali M. Riazi, Sarah Y. Kwon, and William L. Stanford -- Investigating the interactions between haemopoietic stem cells and their niche : methods for the analysis of stem cell homing and distribution within the marrow following transplantation / Brenda Williams and Susan K. Nilsson -- Ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells / Valérie Cortin, Nicolas Pineault, and Alain Garnier -- Ex vivo generation of human red blood cells : a new advance in stem cell engineering / Luc Douay and Marie-Catherine Giarratana -- Isolation and manipulation of mammalian neural stem cells in vitro / Claudio Giachino, Onur Basak, and Verdon Taylor -- Isolation, expansion, and differentiation of mouse skin-derived precursors / Karl J.L. Fernandes and Freda D. Miller -- Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord / Hynek Wichterle, Mirza Peljto, and Stephane Nedelec -- Transplantation of neural stem/progenitor cells into developing and adult CNS / Tong Zheng ... [et al.] -- Transplantation of embrynic stem cell-derived dopaminergic neurons in MPTP-treated monkeys / Jun Takahashi, Yasushi Takagi, and Hidemoto Saiki -- Isolation and culture of epithelial stem cells / Jonathan A. Nowak and Elaine Fuchs -- Regeneration of skin and cornea by tissue engineering / Danielle Larouche ... [et al.] -- Prospective isolation of mesenchymal stem cells from mouse compact bone / Brenton J. Short, Nathalie Brouard, and Paul J. Simmons -- Isolation, propagation, and characterization of human umbilical cord perivascular cells (HUCPVCs) / Rahul Sarugaser ... [et al.] -- Bone marrow-derived mesenchymal stem cells : isolation, expansion, characterization, viral transduction, and production of conditioned medium / Massimilano Gnecchi and Luis G. Melo -- Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells / Vasily Shinin, Barbara Gayraud-Morel, and Shahragim Tajbakhsh -- Isolation and grafting of single muscle fibres / Charlotte A. Collins and Peter S. Zammit -- Differentiation and dynamic analysis of primitive vessels from embryonic stem cells / Gefei Zeng and Victoria L. Bautch -- Derivation of contractile smooth muscle cells from embryonic stem cells / Sanjay Sinha, Mark H. Hoofnagle, and Gary K. Owens -- Islet-derived progenitors as a source of in vitro islet regeneration / Stephen Hanley and Lawrence Rosenberg -- Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers / Thomas D. Shupe ... [et al.] -- Reprogramming of liver to pancreas / Shifaan Thowfeequ ... [et al.]
  • Digital
    Binseng Wang.
    Atypon2009
    Technology is essential to the delivery of health care but it is still only a tool that needs to be deployed wisely to ensure beneficial outcomes at reasonable costs. Among various categories of health technology, medical equipment has the unique distinction of requiring both high initial investments and costly maintenance during its entire useful life. This characteristic does not, however, imply that medical equipment is more costly than other categories, provided that it is managed properly. The foundation of a sound technology management process is the planning and acquisition of equipment, collectively called technology incorporation. This lecture presents a rational, strategic process for technology incorporation based on experience, some successful and many unsuccessful, accumulated in industrialized and developing countries over the last three decades. The planning step is focused on establishing a Technology Incorporation Plan (TIP) using data collected from an audit of existing technology, evaluating needs, impacts, costs, and benefits, and consolidating the information collected for decision making. The acquisition step implements TIP by selecting equipment based on technical, regulatory, financial, and supplier considerations, and procuring it using one of the multiple forms of purchasing or agreements with suppliers. This incorporation process is generic enough to be used, with suitable adaptations, for a wide variety of health organizations with different sizes and acuity levels, ranging from health clinics to community hospitals to major teaching hospitals and even to entire health systems. Such a broadly applicable process is possible because it is based on a conceptual framework composed of in-depth analysis of the basic principles that govern each stage of technology lifecycle. Using this incorporation process, successful TIPs have been created and implemented, thereby contributing to the improvement of healthcare services and limiting the associated expenses.
  • Digital
    edited by Marcos Luciano Bruschi.
    Knovel2015
  • Digital
    edited by Karen M. Polizzi, Cleo Kontoravdi.
    Springer Protocols2013
    In Synthetic Biology , expert researchers in the field provide the latest developments in molecular biology techniques used in Synthetic Biology. Focusing on computational tools that will aid in systematising the design and construction of parts and systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Biology seeks to aid scientists in the further study of developing new biological components and systems.
  • Digital
    Markus Schmidt ... [et al.], editors.
    Springer2009
    Introduction / Markus Schmidt -- That Was the Synthetic Biology That Was / Luis Campos -- An Introduction to Synthetic Biology / Carolyn M.C. Lam, Miguel Godinho and Vítor A.P. Martins dos Santos -- Computational Design in Synthetic Biology / Maria Suarez, Guillermo Rodrigo, Javier Carrera and Alfonso Jaramillo -- The Ethics of Synthetic Biology: Outlining the Agenda / Anna Deplazes, Agomoni Ganguli-Mitra and Nikola Biller-Andorno -- Do I Understand What I Can Create? Biosafety Issues in Synthetic Biology / Markus Schmidt -- Security Issues Related to Synthetic Biology Between Threat Perceptions and Governance Options / Alexander Kelle -- The Intellectual Commons and Property in Synthetic Biology / Kenneth A. Oye and Rachel Wellhausen -- Governing Synthetic Biology: Processes and Outcomes / Joyce Tait -- Synthetic Biology and the Role of Civil Society Organizations Shaping the Agenda and Arena of the Public Debate / Dirk Stemerding, Huib de Vriend, Bart Walhout and Rinie van Est -- Summary and Conclusions / Alexander Kelle.
  • Digital
    edited by Huimin Zhao.
    ScienceDirect2013
    Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms. Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomesHighlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications. Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.
  • Digital
    Sang Yup Lee, editor.
    Springer2009
  • Digital
    Aleš Prokop, Seth Michelson.
    Springer2012
  • Digital
    Asfar S. Azmi, editor.
    Springer2012
    Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • Digital
    edited by Edison T. Liu and Douglas A. Lauffenburger.
    ScienceDirect2010
  • Digital
    Christoph Wittmann, Sang Yup Lee, editors.
    Springer2012
    Preface / Christoph Wittmann and Sang Yup Lee -- 1. Genome-scale network modeling / Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth, and Bernhard Ø. Palsson -- 2. Kinetic modeling of metabolic networks / Daniel C. Zielinski and Bernhard Ø. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis / Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, and Hiroshi Shimizu -- 4. Technologies for bio-systems engineering / Sonja Billerbeck, Sven Dietz, Gaspar Morgado, and Sven Panke -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals / Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, and Sang Yup Lee -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels / Judith Becker, Stefanie Kind, and Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites / Eleftherios T. Papoutsakis and Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum / I. Emrah Nikerel, Peter J.T. Verheijen, Walter M. van Gulik, and Joseph J. Heijnen -- 9. Bridging omics technologies with synthetic biology in yeast industrial biotechnology / António Roldão, Il-Kwon Kim, and Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering / Tomohisa Hasunuma, Fumio Matsuda, and Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism / Paulo A. Gameiro, Christian M. Metallo, and Gregory Stephanopoulos.
  • Digital
    Dennis R. Cooley.
    Springer2010
    Applied groundwork for a practical moral code. Introduction ; Definitions ; Professional moral codes ; USDA study : methodology and results ; Formalization and evaluation of the USDA study's moral codes ; Formalization of the combination moral code ; Problems for the combination moral code ; Conclusion -- A practical moral code. Introduction ; Utilitarianism ; What is a reasonable person? ; RPU's benefits ; Respecting persons ; Working toward a plausible distributive/social justice principle ; The moral paradigm test ; Conclusion -- Are transgenic organisms, biotechnology, and technology unnatural? Introduction ; The unnatural is unethical argument ; The weak definitions ; A "playing God" argument ; More complex meanings of the unnatural ; Arguments from evolution ; Conclusion -- A natural theory of value. Introduction ; Naturalness as sacredness ; Beginning an axiology ; The benefit of the doubt principle ; Intrinsically valuable things and their rankings ; Is nature or the biosphere alive? ; Arguments against nature's intrinsic value ; Conclusion -- Applying PMC to a few transgenic technology issues. Introduction ; The practical moral code again ; Transgenics and RPU ; Transgenics and QCI ; Legal/moral questions ; Conclusion.
  • Digital
    Philippe A. Liverneaux, Stacey H. Berner, Michael S. Bednar, Sijo J. Parekattil, Gustavo Mantovani Ruggiero, Jesse C. Selber, editors.
    Springer2013
    Part 1. GENERAL -- History of Microsurgery / Yoshikazu Ikuta -- History of Telesurgery / James Wall and Jacques Marescaux -- Description of Robots / Jesse Creed Selber -- Instruments / Sijo Joseph Parekatti and Michael Moran -- Robot Installation in Telemicrosurgery / Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux -- Part 2. TRAINING -- Earthworms / Gustavo Mantovani Ruggiero -- Vessels / Joo-Yup Lee and Alexander Y. Shin -- Nerves / Stacey H. Berner -- Part 3. EXPERIMENTAL RESEARCH -- Free Tissue Transfer / Stacey H. Berner -- Tele-endomicrosurgery / Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux -- Brachial Plexus Repair / Gustavo Mantovani Ruggiero and Philippe Liverneaux -- Tendon Transfer / Michael S. Bednar -- Part 4. CLINICAL APPLICATIONS -- Nerve Entrapment / Jose Carlos Garcia Jr. -- Nerve Repair / Stacey H. Berner -- Brachial Plexus / Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux -- Skin Flaps / Thomas Lauwers, Tom Van Mulken and Darren Booi -- Muscle Flaps / Jesse Creed Selber and John C. Pedersen -- Head and Neck / Jesse Creed Selber -- Urology / Sijo Joseph Parekattil -- Part 5. PERSPECTIVES -- Supermicrosurgery / Takeshi Todokoro and Isao Koshima -- Network / Catherine Jane Mohr.
  • Digital/Print
    edited by José Luis Pedraz, Gorka Orive.
    Digital : Springer2010
    Print2010
    Highlights and trends in cell encapsulation / Gorka Orive and José Luis Pedraz -- Biomaterials in cell microencapsulation / Edorta Santos ... [et al.] -- Development of subsieve size capsules and application to cell therapy / Shinji Sakai and Koei Kawakami -- Regulatory considerations in application of encapsulated cell therapies / J. van Zanten and Paul de Vos -- Treatment of diabetes with encapsulated islets / Paul de Vos, Milica Spasojevic, and Marijke M. Faas -- Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules / Ainhoa Murua ... [et al.] -- Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering, and cell therapy / Zun Chang Liu and Thomas Ming Swi Chang -- Microencapsulated choroid plexus epithelial cell transplants for repair of the brain / Christopher G. Thanos, Briannan Bintz, and Dwaine F. Emerich -- Therapeutic application of cell microencapsulation in cancer / Brian Salmons and Walter H. Gunzburg -- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery / Adam Mendelsohn and Tejal Desai -- Cell microencapsulation / Grace J. Lim ... [et al.] -- Commercial applicability of cell microancapsulation : a review of intellectual property rights / Stephan M. Meier.
  • Digital
    Norbert Pallua, Christoph V. Suschek, editors.
    Springer2011
    BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
  • Digital
    Harold S. Bernstein, editor.
    Springer2011
    pt. 1. Stem cells -- pt. 2. Biomaterials and the extracellular environment -- pt. 3. Engineered tissue -- pt. 4. Synthetic organs -- pt. 5. Immune response -- pt. 6. Animal models.
  • Digital
    edited by Ronald Simon.
    Springer Protocols2010
    Applications of tissue microarray technology -- Quality aspects of TMA analysis -- Representativity of TMA studies -- Recipient block TMA technique -- Protocol for constructing tissue arrays by cutting edge matrix assembly -- Hypodermic needle without recipient paraffin block technique -- Resin technologies : construction and staining of resin TMA's -- Tissue microarrays from frozen tissues-OCT technique -- An alternative technology to prepare tissue microarray using frozen tissue samples -- Building "tissue" microarrays from suspension cells -- Tissue microarrays from biopsy specimens -- Immunohistochemical analysis of tissue microarrays -- DNA copy number analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization -- Automated analysis of tissue microarrays -- Digital microscopy for boosting database integration and analysis in TMA studies -- From gene to clinic : TMA-based clinical validation of molecular markers in prostate cancer
  • Digital
    Hossein Baharvand, editor.
    Springer2009
  • Digital
    edited by Steven Kanner.
    Springer2014
  • Digital
    edited by Bernhard Suter, Erich E. Wanker.
    Springer Protocols2012
    Matrix-based yeast two-hybrid screen strategies and comparison of systems / Roman Häuser [and others] -- Array-based yeast two-hybrid screens : a practical guide / Roman Häuser [and others] -- High-throughput yeast two-hybrid screening / George G. Roberts III [and others] -- A stringent yeast two-hybrid matrix screening approach for protein-protein interaction discovery / Josephine M. Worseck [and others] -- High-throughput yeast two-hybrid screening of complex cDNA libraries / Kerstin Mohr and Manfred Koegl -- Virus-human cell interactomes / Lionel Tafforeau, Chantal Rabourdin-Combe, and Vincent Lotteau -- Interactome mapping in malaria parasites : challenges and opportunities / Douglas J. LaCount -- Mapping interactomes with high coverage and efficiency using the shifted transversal design / Xiaofeng Xin, Charles Boone, and Nicolas Thierry-Mieg -- Assigning confidence scores to protein-protein interactions / Jingkai Yu, Thilakam Murali, and Russell L. Finley Jr. -- The integration and annotation of the human interactome in the UniHI database / Gautam Chaurasia and Matthias Futschik -- Gene-centered yeast one-hybrid assays / John S. Reece-Hoyes and Albertha J.M. Walhout -- One- plus two-hybrid system for the efficient selection of missense mutant alleles defective in protein-protein interactions / Ji Young Kim, Ok Gu Park, and Young Chul Lee -- Investigation of membrane protein interactions using the split-ubiquitin membrane yeast two-hybrid system / Julia Petschnigg [and others] -- Application of the split-protein sensor trp1 to protein interaction discovery in the yeast Saccharomyces cerevisiae / Mandana Rezwan [and others] -- Tetracycline repressor-based mammalian two-hybrid systems / Kathryn Moncivais and Zhiwen Jonathan Zhang -- The fluorescent two-hybrid (F2H) assay for direct analysis of protein-protein interactions in living cells / Kourosh Zolghadr, Ulrich Rothbauer, and Heinrich Leonhardt -- ArrayMAPPIT : a screening platform for human protein interactome analysis / Sam Lievens [and others] -- MAPPIT as a high-throughput screening assay for modulators of protein-protein interactions in HIV and HCV / Bertrand Van Schoubroeck [and others] -- Integrated measurement of split TEV and cis-regulatory assays using EXT encoded reporter libraries / Anna Botvinik and Moritz J. Rossner.
  • Digital
    edited by Michael C. Flickinger.
    ProQuest Ebook Central2013
    "This reference work provides information on industrial cell growth, gene expression systems, fermentation media, process development, bioreactor design, process sensing and control, process analytical technologies (PAT) as well as fermentation cGMP operations"-- Provided by publisher.
  • Digital
    Boris Bogdan, Ralph Villiger.
    Springer2008
  • Digital
    Adam Richard Sciambi.
    Two dimensional electron systems (2DESs) at semiconductor interfaces are a useful medium for studying complex physics due to their very low disorder and relative simplicity. Many interesting effects, such as the quantum Hall effect, have been discovered through transport measurements in such systems. Unfortunately, the interfacial nature of 2DESs and the related surface energy barrier means that directly accessing them from the surface is difficult. This has limited our understanding of theoretically-predicted, spatially-organized effects such Wigner-crystal microemulsions and quantum Hall stripes, which have been probed only indirectly. In this dissertation, we develop a new type of local probe that circumvents the surface barrier by tunneling into a 2DES from a second 2DES grown nearby. The interlayer tunneling happens directly below a scanned metal tip outside the sample, behaving as a virtual tip in a system we call Virtual Scanning Tunneling Microscopy (VSTM). In the first half of the dissertation, we discuss a novel mechanism for tuning tunneling locally between two 2DESs. Its premise is that raising a quantum potential well next to an adjacent barrier is energetically similar to lowering the barrier relative to a fixed well. A lower barrier leads to the quantum well wave function extending into it and to increased tunneling into a second quantum well on the opposite side. We characterize this mechanism in a GaAs-AlGaAs heterostructure as a new type of transistor. In the second half of the dissertation, results from a working VSTM system are presented, with local interlayer tunneling revealing hidden features in the interfaces below the surface.
  • Digital
    edited by Baochuan Lin and Banahalli Ratna.
    Springer Protocols2014
    Genetic engineering and chemical conjugation of potato virus X / Karin L. Lee, Kerstin [and four others] -- Genetically engineering adenoviral vectors for gene therapy / Lynda Coughlan - Simulated digestion for testing the stability of edible vaccine based on Cucumber mosaic virus (CMV) chimeric particle display Hepatitis C virus (HCV) peptide / Antonella Vitti [and three others] -- Using phage as a platform to select cancer cell-targeting peptides / Xin Li and Chuanbin Mao -- Bacteriophage T4 capsid packaging and unpackaging of DNA and proteins / Julienne M. Mullaney and Lindsay W. Black -- Templated mineralization by charge-modified cowpea mosaic virus / Alaa A.A. Aljabali and David J. Evans -- Polyelectrolyte-modified cowpea mosaic virus for the synthesis of gold nanoparticles / Alaa A.A. Aljabali and David J. Evans -- Tobacco mosaic virus capsid protein as targets for the self-assembly of gold nanoparticles / Omar K. Zahr and Amy Szuchmacher Blum -- Tobacco mosaic virus assembled high aspect ratio surfaces / Adam D. Brown and James N. Culver -- Phage as a template to grow bone mineral nanocrystals / Binrui Cao, Hong Xu, and Chuanbin Mao -- Genetic engineering and characterization of cowpea mosaic virus empty virus-like particles / Frank Sainsbury [and five others] -- A programmable fluorescent viral nanoblock : sensing made easy in a single step / Carissa M. Soto -- Chemical modification of the inner and outer surfaces of tobacco mosaic virus (TMV) / Michael A. Bruckman and Nicole F. Steinmetz -- Engineered bacteriophage T4 nanoparticles for cellular imaging / Jinny L. Liu and Kelly L. Robertson -- Phage-displayed single domain antibodies as recognition elements / Ellen Goldman and Scott Walper -- Molecular targeted viral nanoparticles as tools for imaging cancer / Choi-Fong Cho [and five others].
  • Digital/Print
    Marianne Manchester, Nicole F. Steinmetz, editors.
    Digital : Springer2009
    Print2009
    Chemical modification of viruses and virus-like particles / E. Strable, M.G. Finn -- Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology / N.F. Steinmetz, T. Lin, G.P. Lomonossoff, J.E. Johnson -- Hybrid assembly of CPMV viruses and surface characteristics of different mutants / N.G. Portney, G. Destito, M. Manchester, M. Ozkan -- A library of protein cage architectures as nanomaterials / M.L. Flenniken ... [et al.] -- Biomedical nanotechnology using virus-based nanoparticles / G. Destito, A. Schneemann, M. Manchester -- Tumor targeting using canine parvovirus nanoparticles / P. Singh.
  • Digital
    Knovel2002
  • Digital
    edited by Francesca Molfino, Flavia Zucco.
    Springer2008
  • Digital
    edited by Valeria Mapelli, Industrial Biotechnology, Chalmers University of Technology, Gothenbug, Sweden.
    Springer Protocols2014
    An overview on selection marker genes for transformation of Saccharomyces cerevisiae -- Natural and modified promoters for tailored metabolic engineering of the yeast Saccharomyces cerevisiae -- Tools for genetic engineering of the yeast Hansenula polymorpha -- Molecular tools and protocols for engineering the acid-tolerant yeast Zygosaccharomyces bailii as a potential cell factory -- Strains and molecular tools for recombinant protein production in Pichia pastoris -- Methods for efficient high-throughput screening of protein expression in recombinant pichia pastoris strains -- Synthetic RNA switches for yeast metabolic engineering: Screening recombinant enzyme libraries -- Generation of arming yeasts with active proteins and peptides via cell surface display system: Cell surface engineering, bio-arming technology -- Genetic engineering of industrial Saccharomyces cerevisiae strains using a selection/counter-selection approach -- Evolutionary engineering of yeast -- Determination of a dynamic feeding strategy for recombinant pichia pastoris strains -- Yeast metabolomics: Sample preparation for a GC/MS based analysis -- 13CC-based metabolic flux analysis in yeast: The Pichia pastoris case -- Pathway activity profiling (PAPi): A tool for metabolic pathway analysis -- QTL mapping by pooled-segregant whole-genome sequencing in yeast -- Genome-scale metabolic models of yeast, methods for their reconstruction, and other applications -- Model-guided identification of gene deletion targets for metabolic engineering in Saccharomyces cerevisiae -- Patents: A tool to bring innovation from the lab bench to the marketplace.

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