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  • Signal and image analysis techniques are becoming more widely used in biomedical and life science applications. With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to some of the applications. It can be used by those both at graduate and specialist levels.
  • pt. 1. Stem cell biology -- pt. 2. Epigenetic and microRNA regulation in stem cells -- pt. 3. Stem cells for therapeutic applications -- pt. 4. Nuclear reprogramming and induced pluripotent stem cells -- pt. 5. Tissue engineering -- pt. 6. Regenerative medicine.
  • pt. 1. Defining, isolating, and characterizing various stem and progenitor cell populations for neovascularization -- pt. 2. In vitro studies for angiogenesis, vasculogenesis, and arteriogenesis -- pt. 3. Stem cell mobilization strategies -- pt. 4. Stem cell transplantation strategies.
  • Interest in the use of stem cells in aesthetic procedures has been increasing rapidly, reflecting the widespread acknowledgment of the tremendous potential of stem cell fat transfer. This is, however, the first book to be devoted entirely to the subject. The book opens by reviewing the history of the development of pluripotent stem cells and the results of research into the biochemistry and physiology of stem cells. Adipose tissue anatomy and survival are discussed, and the wide range of aesthetic procedures involving stem cell fat transfer are then described in detail. These procedures relate to the face, breast, buttocks, legs, hands, penis, and Poland syndrome. In addition, potential risks and complications are identified. Stem Cells in Aesthetic Procedures: Art, Science, and Clinical Techniques is completely up to date and has been written by leading experts in the field. It will be an invaluable source of information for students, beginners, and experienced surgeons in the fields of plastic surgery, general surgery, cosmetic surgery, facial plastic surgery, otolaryngology, ophthalmology, and oral maxillofacial surgery.
  • Stem cells in regenerative medicine 2009, Springer Protocols
    Derivation and manipulation of murine embryonic stem cells / Alexander Meissner, Sarah Eminli, and Rudolf Jaenisch -- Patterning mouse and human embryonic stem cells using micro-contact printing / Raheem Peerani ... [et al.] -- Efficient gene knockdowns in human embryonic stem cells using lentiviral-based RNAi / Asmin Tulpule and George Q. Daley -- Measurement of cell-penetrating peptide-mediated transduction of adult hematopoietic stem cells / Aziza P. Manceur and Julie Audet -- Stem cell sources for regenerative medicine / Ali M. Riazi, Sarah Y. Kwon, and William L. Stanford -- Investigating the interactions between haemopoietic stem cells and their niche : methods for the analysis of stem cell homing and distribution within the marrow following transplantation / Brenda Williams and Susan K. Nilsson -- Ex vivo megakaryocyte expansion and platelet production from human cord blood stem cells / Valérie Cortin, Nicolas Pineault, and Alain Garnier -- Ex vivo generation of human red blood cells : a new advance in stem cell engineering / Luc Douay and Marie-Catherine Giarratana -- Isolation and manipulation of mammalian neural stem cells in vitro / Claudio Giachino, Onur Basak, and Verdon Taylor -- Isolation, expansion, and differentiation of mouse skin-derived precursors / Karl J.L. Fernandes and Freda D. Miller -- Xenotransplantation of embryonic stem cell-derived motor neurons into the developing chick spinal cord / Hynek Wichterle, Mirza Peljto, and Stephane Nedelec -- Transplantation of neural stem/progenitor cells into developing and adult CNS / Tong Zheng ... [et al.] -- Transplantation of embrynic stem cell-derived dopaminergic neurons in MPTP-treated monkeys / Jun Takahashi, Yasushi Takagi, and Hidemoto Saiki -- Isolation and culture of epithelial stem cells / Jonathan A. Nowak and Elaine Fuchs -- Regeneration of skin and cornea by tissue engineering / Danielle Larouche ... [et al.] -- Prospective isolation of mesenchymal stem cells from mouse compact bone / Brenton J. Short, Nathalie Brouard, and Paul J. Simmons -- Isolation, propagation, and characterization of human umbilical cord perivascular cells (HUCPVCs) / Rahul Sarugaser ... [et al.] -- Bone marrow-derived mesenchymal stem cells : isolation, expansion, characterization, viral transduction, and production of conditioned medium / Massimilano Gnecchi and Luis G. Melo -- Template DNA-strand co-segregation and asymmetric cell division in skeletal muscle stem cells / Vasily Shinin, Barbara Gayraud-Morel, and Shahragim Tajbakhsh -- Isolation and grafting of single muscle fibres / Charlotte A. Collins and Peter S. Zammit -- Differentiation and dynamic analysis of primitive vessels from embryonic stem cells / Gefei Zeng and Victoria L. Bautch -- Derivation of contractile smooth muscle cells from embryonic stem cells / Sanjay Sinha, Mark H. Hoofnagle, and Gary K. Owens -- Islet-derived progenitors as a source of in vitro islet regeneration / Stephen Hanley and Lawrence Rosenberg -- Isolation and characterization of hepatic stem cells, or "oval cells," from rat livers / Thomas D. Shupe ... [et al.] -- Reprogramming of liver to pancreas / Shifaan Thowfeequ ... [et al.]
  • Technology is essential to the delivery of health care but it is still only a tool that needs to be deployed wisely to ensure beneficial outcomes at reasonable costs. Among various categories of health technology, medical equipment has the unique distinction of requiring both high initial investments and costly maintenance during its entire useful life. This characteristic does not, however, imply that medical equipment is more costly than other categories, provided that it is managed properly. The foundation of a sound technology management process is the planning and acquisition of equipment, collectively called technology incorporation. This lecture presents a rational, strategic process for technology incorporation based on experience, some successful and many unsuccessful, accumulated in industrialized and developing countries over the last three decades. The planning step is focused on establishing a Technology Incorporation Plan (TIP) using data collected from an audit of existing technology, evaluating needs, impacts, costs, and benefits, and consolidating the information collected for decision making. The acquisition step implements TIP by selecting equipment based on technical, regulatory, financial, and supplier considerations, and procuring it using one of the multiple forms of purchasing or agreements with suppliers. This incorporation process is generic enough to be used, with suitable adaptations, for a wide variety of health organizations with different sizes and acuity levels, ranging from health clinics to community hospitals to major teaching hospitals and even to entire health systems. Such a broadly applicable process is possible because it is based on a conceptual framework composed of in-depth analysis of the basic principles that govern each stage of technology lifecycle. Using this incorporation process, successful TIPs have been created and implemented, thereby contributing to the improvement of healthcare services and limiting the associated expenses.
  • Introduction / Markus Schmidt -- That Was the Synthetic Biology That Was / Luis Campos -- An Introduction to Synthetic Biology / Carolyn M.C. Lam, Miguel Godinho and Vítor A.P. Martins dos Santos -- Computational Design in Synthetic Biology / Maria Suarez, Guillermo Rodrigo, Javier Carrera and Alfonso Jaramillo -- The Ethics of Synthetic Biology: Outlining the Agenda / Anna Deplazes, Agomoni Ganguli-Mitra and Nikola Biller-Andorno -- Do I Understand What I Can Create? Biosafety Issues in Synthetic Biology / Markus Schmidt -- Security Issues Related to Synthetic Biology Between Threat Perceptions and Governance Options / Alexander Kelle -- The Intellectual Commons and Property in Synthetic Biology / Kenneth A. Oye and Rachel Wellhausen -- Governing Synthetic Biology: Processes and Outcomes / Joyce Tait -- Synthetic Biology and the Role of Civil Society Organizations Shaping the Agenda and Arena of the Public Debate / Dirk Stemerding, Huib de Vriend, Bart Walhout and Rinie van Est -- Summary and Conclusions / Alexander Kelle.
  • Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms. Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomesHighlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications. Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.
  • Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • Preface / Christoph Wittmann and Sang Yup Lee -- 1. Genome-scale network modeling / Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth, and Bernhard Ø. Palsson -- 2. Kinetic modeling of metabolic networks / Daniel C. Zielinski and Bernhard Ø. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis / Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, and Hiroshi Shimizu -- 4. Technologies for bio-systems engineering / Sonja Billerbeck, Sven Dietz, Gaspar Morgado, and Sven Panke -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals / Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, and Sang Yup Lee -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels / Judith Becker, Stefanie Kind, and Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites / Eleftherios T. Papoutsakis and Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum / I. Emrah Nikerel, Peter J.T. Verheijen, Walter M. van Gulik, and Joseph J. Heijnen -- 9. Bridging omics technologies with synthetic biology in yeast industrial biotechnology / António Roldão, Il-Kwon Kim, and Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering / Tomohisa Hasunuma, Fumio Matsuda, and Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism / Paulo A. Gameiro, Christian M. Metallo, and Gregory Stephanopoulos.
  • Part 1. GENERAL -- History of Microsurgery / Yoshikazu Ikuta -- History of Telesurgery / James Wall and Jacques Marescaux -- Description of Robots / Jesse Creed Selber -- Instruments / Sijo Joseph Parekatti and Michael Moran -- Robot Installation in Telemicrosurgery / Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux -- Part 2. TRAINING -- Earthworms / Gustavo Mantovani Ruggiero -- Vessels / Joo-Yup Lee and Alexander Y. Shin -- Nerves / Stacey H. Berner -- Part 3. EXPERIMENTAL RESEARCH -- Free Tissue Transfer / Stacey H. Berner -- Tele-endomicrosurgery / Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux -- Brachial Plexus Repair / Gustavo Mantovani Ruggiero and Philippe Liverneaux -- Tendon Transfer / Michael S. Bednar -- Part 4. CLINICAL APPLICATIONS -- Nerve Entrapment / Jose Carlos Garcia Jr. -- Nerve Repair / Stacey H. Berner -- Brachial Plexus / Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux -- Skin Flaps / Thomas Lauwers, Tom Van Mulken and Darren Booi -- Muscle Flaps / Jesse Creed Selber and John C. Pedersen -- Head and Neck / Jesse Creed Selber -- Urology / Sijo Joseph Parekattil -- Part 5. PERSPECTIVES -- Supermicrosurgery / Takeshi Todokoro and Isao Koshima -- Network / Catherine Jane Mohr.
  • Highlights and trends in cell encapsulation / Gorka Orive and José Luis Pedraz -- Biomaterials in cell microencapsulation / Edorta Santos ... [et al.] -- Development of subsieve size capsules and application to cell therapy / Shinji Sakai and Koei Kawakami -- Regulatory considerations in application of encapsulated cell therapies / J. van Zanten and Paul de Vos -- Treatment of diabetes with encapsulated islets / Paul de Vos, Milica Spasojevic, and Marijke M. Faas -- Epo delivery by genetically engineered C2C12 myoblasts immobilized in microcapsules / Ainhoa Murua ... [et al.] -- Artificial cell microencapsulated stem cells in regenerative medicine, tissue engineering, and cell therapy / Zun Chang Liu and Thomas Ming Swi Chang -- Microencapsulated choroid plexus epithelial cell transplants for repair of the brain / Christopher G. Thanos, Briannan Bintz, and Dwaine F. Emerich -- Therapeutic application of cell microencapsulation in cancer / Brian Salmons and Walter H. Gunzburg -- Inorganic nanoporous membranes for immunoisolated cell-based drug delivery / Adam Mendelsohn and Tejal Desai -- Cell microencapsulation / Grace J. Lim ... [et al.] -- Commercial applicability of cell microancapsulation : a review of intellectual property rights / Stephan M. Meier.
  • "This book bridges the gap between nanotechnology and regenerative medicine to facilitate their transition from lab to the clinic. It compiles important aspects of the basic science and fundamental principles to current nanotechnological innovations in biomaterials, cell, tissue, and organ engineering, and their clinical relevance, as well as future trends in regenerative medicine. It is intended for a wide audience including students, researchers, professors, and industrial experts working in the tields of biomaterial science and engineering, nanoscience and nanotechnology, bioengineering, cell biology, biomedical sciences, tissue engineering, and nanomedicine"--Provided by publisher.
  • BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
  • pt. 1. Stem cells -- pt. 2. Biomaterials and the extracellular environment -- pt. 3. Engineered tissue -- pt. 4. Synthetic organs -- pt. 5. Immune response -- pt. 6. Animal models.
  • Applications of tissue microarray technology -- Quality aspects of TMA analysis -- Representativity of TMA studies -- Recipient block TMA technique -- Protocol for constructing tissue arrays by cutting edge matrix assembly -- Hypodermic needle without recipient paraffin block technique -- Resin technologies : construction and staining of resin TMA's -- Tissue microarrays from frozen tissues-OCT technique -- An alternative technology to prepare tissue microarray using frozen tissue samples -- Building "tissue" microarrays from suspension cells -- Tissue microarrays from biopsy specimens -- Immunohistochemical analysis of tissue microarrays -- DNA copy number analysis on formalin-fixed paraffin-embedded tissues in TMA format by RNA in situ hybridization -- Automated analysis of tissue microarrays -- Digital microscopy for boosting database integration and analysis in TMA studies -- From gene to clinic : TMA-based clinical validation of molecular markers in prostate cancer
  • Ch. 1. An introduction to VNPs and nanotechnology -- ch. 2. Overview of the manifold VNPs used in nanotechnology -- ch. 3. Production of VNPs, VLPs, and chimeras -- ch. 4. The art of bioconjugation : functionalization of VNPs -- ch. 5. Encapsulating materials within VNPs -- ch. 6. VNPs as templates for materials synthesis -- ch. 7. Playing "nano-lego" : VNPs as building blocks for the construction of multi-dimensional arrays -- ch. 8. VNPs as tools for nanomedicine -- ch. 9. Summary and outlook.
  • Chemical modification of viruses and virus-like particles / E. Strable, M.G. Finn -- Structure-based engineering of an icosahedral virus for nanomedicine and nanotechnology / N.F. Steinmetz, T. Lin, G.P. Lomonossoff, J.E. Johnson -- Hybrid assembly of CPMV viruses and surface characteristics of different mutants / N.G. Portney, G. Destito, M. Manchester, M. Ozkan -- A library of protein cage architectures as nanomaterials / M.L. Flenniken ... [et al.] -- Biomedical nanotechnology using virus-based nanoparticles / G. Destito, A. Schneemann, M. Manchester -- Tumor targeting using canine parvovirus nanoparticles / P. Singh.
  • β-barrel outer membrane channel proteins (OMP) have great potential as robust and flexible models or components in nanotechnology. Over the last decade biotechnological techniques allowed to expand the natural characteristics of OMPs by modifying their geometry and properties without affecting the overall protein structure and stability. The present book is oriented towards a broad group of readers including graduate students and advanced researchers. The β-barrel structure serviceability for the nano-material design will be its chief topic giving a general introduction to the field of OMP based nano-component development as well as the state of the art of the involved research. On the example of the E. coli FhuA the transformation of an OMP into a tailored nano-channel to be adapted to a non-biological synthetic (i.e. polymer) environment, rendering it competitive with artificial non-biological nano-pores will be outlined specifically the design of a set of protein nano-channels with tailored geometry (diameter, length), conductance and functionality will be reported as a case study. In order to make this book a valuable source of information for both biotechnologists and other scientists interested in bio-nanotechnology an overview of the different steps involved in the nano-channel protein design and production will be reported. The scientific strategy from concept design, theoretical considerations, genetic engineering and large scale production, to system assembly and biophysical characterization with an overview on technological applications including membrane/polymersome technology, will be described.

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