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Biomedical Engineering

  • "This handbook presents methods that improve the accuracy in glucose prediction based on infrared absorption spectroscopy, recent studies on the influence of acute hyperglycemia on cerebral blood flow, and the correlation between diabetes and the thermo-optical response of human skin. It examines skin glucose monitoring by near-infrared spectroscopy (NIR), fluorescence-based glucose biosensors, and a photonic crystal contact lens sensor. The contributors also explore problems of polarimetric glucose sensing in transparent and turbid tissues as well as offer a high-resolution optical technique for noninvasive, continuous, and accurate blood glucose monitoring and glucose diffusion measurement."--BOOK JACKET.
  • The first chapter describes the health care delivery systems in Canada and in the U.S. This is followed by examples of various approaches used to measure physiological variables in humans, either for the purpose of diagnosis or monitoring potential disease conditions; a brief description of sensor technologies is included. The function and role of the clinical engineer in managing medical technologies in industrialized and in developing countries are presented. This is followed by a chapter on patient safety (mainly electrical safety and electromagnetic interference); it includes a section on how to minimize liability and how develop a quality assurance program for technology management. The next chapter discusses applications of telemedicine, including technical, social, and ethical issues. The last chapter presents a discussion on the impact of technology on health care and the technology assessment process.
  • Chapter 7 presents some statistics on the occurrence of medical errors and adverse events, and includes some technological solutions. A chapter on electronic medical records follows. The knowledge management process divided into four steps is described; this includes a discussion on data acquisition, storage, and retrieval. The next two chapters discuss the other three steps of the knowledge management process (knowledge discovery, knowledge translation, knowledge integration and sharing). The last chapter briefly discusses usability studies and clinical trials. The two parts consolidate material that supports courses on technology development and management issues in health care institutions. It can be useful for anyone involved in design, development, or research, whether in industry, hospitals, or government.
  • Anatomy, Physiology, Congenital Defects, and Disease --The Anatomy and Function of the Atrioventricular Valves /Michael G. Bateman, Jason L. Quill, Alexander J. Hill, Paul A. Iaizzo --The Anatomy and Function of the Semilunar Valves /Michael G. Bateman, Jason L. Quill, Alexander J. Hill, Paul A. Iaizzo --Congenital Heart Defects That Include Cardiac Valve Abnormalities /Roosevelt Bryant III --Acquired Valve Disease and Processes /Cindy M. Martin --Valve Repair and Replacement --History of Heart Valve Repair /Lauren B. Kwasny, Richard W. Bianco, Luis H. Toledo-Pereyra, --Heart Valve Disease /Ranjit John, Kenneth Liao --Advanced 3D Imaging and Transcatheter Valve Repair/Implantation /Paul Schoenhagen, Andrew C. Y. To --Transcatheter Mitral Repair and Replacement /Jason L. Quill, Ana R. Menk, Gilbert H. L. Tang --Percutaneous Pulmonary Valve Implantation: The First Transcatheter Valve /Silvia Schievano, Andrew M. Taylor, Philipp Bonhoeffer --Transcatheter Aortic Valve Implantation /Nicolo Piazza, Darren Mylotte --Tissue-Engineered Heart Valves /Jillian B. Schmidt, Robert T. Tranquillo --Testing and Regulatory Issues --In Vitro Testing of Heart Valve Substitutes /Timothy A. Kelley, Sal Marquez, Carl F. Popelar --Numerical Methods for Design and Evaluation of Prosthetic Heart Valves /Michael J. Schendel, Carl F. Popelar --Animal Models for Cardiac Valve Research /Sarah E. Ahlberg, Michael G. Bateman, Michael D. Eggen, Jason L. Quill --The Use of Isolated Heart Models and Anatomic Specimens as Means to Enhance the Design and Testing of Cardiac Valve Therapies /Michael G. Bateman, Alexander J. Hill, Jason L. Quill, Michael D. Eggen --Successful Development and Regulatory Approval of Replacement Cardiac Valves /Stephen A. Howard, Michael G. Bateman, Timothy G. Laske, Paul A. Iaizzo --Clinical Trial Requirements for Cardiac Valves /Jenna C. Iaizzo, Anna T. F. Lovas.
  • Holoscopy 2014, Springer
    Holoscopy is a new tomographic imaging modality that combines techniques of digital holography with Fourier-domain optical coherence tomography (FD-OCT). Dierck Hillmann gives a theoretical introduction to the mathematics and physics of holoscopy and develops an efficient numerical reconstruction procedure. Compared to FD-OCT, holoscopy provides unique advantages by enabling tomographic imaging without a limited depth of focus, but results in an increased numerical cost for reconstruction. In further chapters, the author introduces techniques for FD-OCT that are relevant to holoscopy as well. He demonstrates and compares numerical reconstruction methods for FD-OCT and shows how motion and dispersion artifacts in FD-OCT can be numerically compensated. Contents Theoretical Introduction to Optical Coherence Tomography and Digital Holography FD-OCT Signal Processing Using the Non-Equispaced Fast Fourier Transform Motion and Dispersion Correction in FD-OCT Holoscopy Target Groups Academics and practitioners in the fields of computer science, optical coherence tomography, digital holography, and medical imaging. The Author Dierck Hillmann received his doctoral degree in the group of Gereon Hüttmann at the Institute of Biomedical Optics in Lübeck and is currently working for a leading company in the fields of science and photonics. The Editor The series Aktuelle Forschung Medizintechnik is edited by Thorsten M. Buzug.
  • Human adult stem cells 2009, Springer
    1. Neural progenitors / Dustin R. Wakeman ... [et al.] -- 2. Multipotent stromal cells (hMSCs) / Margaret Wolfe ... [et al.] -- 3. Endothelium / Sangmo Kwon, Takayuki Asahara -- 4. Lung / Rabindra Tirouvanziam, Megha Makam, Bruno Péault -- 5. Eye / Maria Notara ... [et al.] -- 6. Colon / F. Iovino ... [et al.] -- 7. Spermatogonia / Makoto C. Nagano, Jonathan R. Yeh, Khaled Zohni -- 8. Hair follicle pluripotent stem (hfPS) cells / Robert M. Hoffman -- 9. Pancreas / Fang-Xu Jiang, Grant Morahan -- 10. Prostate / C. Foley ... [et al.].
  • Part 1.Historical and Socio-Cultural Contexts in Medical Research /British Responses to Nazi Medical War Crimes /Fiona McClenaghan --History and its Relevance in the Development and Teaching of Research Ethics /Rael D. Strous --Human Embryo Research and Islamic Bioethics: A View from Iran /Mansooreh Saniei --From Farming to Pharming: Transcending of Bodily Existence as a Question of Medical Ethics in an Intercultural Context /Axel Siegemund --Introduction /Jan Schildmann, Verena Sandow, Oliver Rauprich and Jochen Vollmann --Part 2.Considerations on Ethical and Legal Regulations for Medical Research /Rethinking the Therapeutic Obligation in Clinical Research /Nunziata Comoretto --Biomedical Research in Developing Countries and International Human Rights Law /Ilja R. Pavone --Research Involving Human Subjects and Human Biological Material from a European Patent Law Perspective. Autonomy, Commodification, Patentability /Tomasz Zimny --The Development and Validation of a Guide for Peruvian Research Ethics Committees to Assist in the Review of Ethical-Scientific Aspects of Clinical Trials /Susy Olave Quispe, Duilio Fuentes Delgado, Gabriela Minaya Martínez, Rosa Surco Ibarra and Martín Yagui Moscoso, et al. --Part 3.Conflicts in Medical Research /Conflicts of Interest in Medical Research: What can Ethics Contribute? /Verena Sandow, Jan Schildmann and Jochen Vollmann --Research Ethics in Genomics Research: Feedback of Individual Genetic Data to Research Participants /Annelien L. Bredenoord and Johannes J. M. van Delden --Regulating "Higher Risk, No Direct Benefit" Studies with Children: Challenging the US Federal Regulations /Anna E. Westra, Jan M. Wit, Rám N. Sukhai and Inez D. de Beaufort --Part 4.New Developments in Medical Research and Ethical Implications /A Paradigm Change in Research Ethics /Rieke van der Graaf and Johannes J. M. van Delden --Translation of Cancer Molecular Biomarkers: Ethical and Epistemological Issues /Flavio D'Abramo and Cecilia Guastadisegni --Rethinking the Ethics of Human Biomedical Non-Interventional Research /Kristi L{tilde}ouk.
  • "This book covers the full range of available imaging modalities and optical methods used to help evaluate material and biological behavior. It also highlights a wide range of optical and biological applications. Each chapter in the text describes a specific application and discusses relevant instrumentation, governing physical principles, data processing procedures, as well as advantages and disadvantages of each modality. Following a broad introduction to key topics, the main chapters are divided between in vitro and in vivo applications. The final section focuses on methods for data processing and analysis"--Provided by publisher.
  • History and development of pacing -- Basic principles of cardiac pacemaker technology -- Heart anatomy and physiology -- Pharmacological treatment of cardiac rhythm disorders -- Pacing modes -- Indications for implantable system treatment -- Leads -- Pacing systems -- Pacemaker timing -- Implantable cardioverter-defibrillators -- Cardiac resynchronization therapy -- Implantation, explantation, and replacement of devices and leads -- Patient follow-up -- Electromagnetic compatibility and technical requirements.
  • Part 1 --Introduction /Rihard Trebše --Joint Replacement: Historical Overview /Rihard Trebše, Anže Mihelič --Biomaterials in Artificial Joint Replacements /Rihard Trebše --The Definition of Prosthetic Joint Infections (PJI) /Rihard Trebše, Andrej Trampuž --Classification of Prosthetic Joint Infections /Rihard Trebše, Anže Mihelič --The Epidemiology of Total Joint Arthroplasty Infections /David J. Jaekel, Kevin L. Ong, Edmund C. Lau --Septic Complications in Arthroplasty /Gerold Labek --Perioperative Antibiotic Prophylaxis in Total Joint Arthroplasty /Nataša Faganeli --Risk Factors for Prosthetic Joint Infections /René Mihalič, Matevž Topolovec --Pathogenesis of Prosthetic Joint Infections /Rihard Trebše, Jurij Štalc --Bacteria-Biomaterial Interactions /Antti Soininen, Emilia Kaivosoja, Jaime Esteban --Biomaterial-Host Interactions in Aseptic and Septic Conditions /Jukka Pajarinen, Yuya Takakubo, Zygmunt Mackiewicz --Influence of Wear Particles on Local and Systemic Immune System /Emmanuel Gibon, Stuart B. Goodman --Diagnostic Evaluations /Rihard Trebše --Synovial Fluid Cytology /René Mihalič, Dunja Terčič --Histological Analysis of Periprosthetic Tissue for Detecting Prosthetic Joint Infection /Andrej Cör --Microbiological Diagnosis of Prosthetic Joint Infection /Jaime Esteban, Concepción Pérez-Jorge, Ramón Pérez-Tanoira --Microbiological Processing of Samples in the Investigation of Suspected Prosthetic Joint Infection /David G. Partridge, Rob Towsend --Part 2 --Molecular Diagnosis of Prosthetic Joint Infection /Jaime Esteban, Diana Molina-Manso, Gema del-Prado --Current Treatment Strategies in Prosthetic Joint Infections /Rihard Trebše Total Ankle Replacement Infections /Michaela Maria Schneiderbauer --Periprosthetic Infection Issues with Osseointegrated (OI) Implant Technology in Amputees /Catherine Loc-Carrillo, Alec C. Runyon, James Peter Beck --The Algorithm for Diagnostic Evaluation and Treatment /Rihard Trebše, Andrej Trampuž --Bone Grafts and Bone Graft Substitutes in Infected Arthroplasty /Martin Clauss, Thomas Ilchmann.
  • Image-guided therapy (IGT) uses imaging to improve the localization and targeting of diseased tissue and to monitor and control treatments. During the past decade, image-guided surgeries and image-guided minimally invasive interventions have emerged as advances that can be used in place of traditional invasive approaches. Advanced imaging technologies such as magnetic resonance imaging (MRI), computed tomography (CT), and positron emission tomography (PET) entered into operating rooms and interventional suites to complement already-available routine imaging devices like X-ray and ultrasound. At the same time, navigational tools, computer-assisted surgery devices, and image-guided robots also became part of the revolution in interventional radiology suites and the operating room. Intraoperative Imaging and Image-Guided Therapy explores the fundamental, technical, and clinical aspects of state-of the-art image-guided therapies. It presents the basic concepts of image guidance, the technologies involved in therapy delivery, and the special requirements for the design and construction of image-guided operating rooms and interventional suites. It also covers future developments such as molecular imaging-guided surgeries and novel innovative therapies like MRI-guided focused ultrasound surgery. IGT is a multidisciplinary and multimodality field in which teams of physicians, nurses, and other professionals, such as physicists, engineers, and computer scientists, collaborate in performing these interventions, an approach that is reflected in the organization of the book. Contributing authors include members of the National Center of Image-Guided Therapy program at Brigham and Womens Hospital and international leaders in the field of IGT.
  • Introduction to bone materials -- Basic bone remodeling theory -- Multifield internal bone remodeling -- Multifield surface bone remodeling -- Theoretical models of bone modeling and remodeling -- Effect of parathyroid hormone on bone metabolism -- Cortical bone remodeling under mechanical stimulus -- Bone remodelling under pulsed electromagnetic fields and clinical applications -- Experiments.
  • Medical devices and systems 2006., CRCnetBASE
    Infrared imaging applied to dentistry -- Use of infrared imaging in veterinary medicine -- Standard procedures for infrared imaging in medicine -- Infrared detectors and detector arrays -- Infrared camera characterization -- Infrared camera and optics for medical applications -- sect. IV. Medical informatics. Hospital information systems: their function and state -- Computer-based patient records -- Overview of standards related to the emerging health care information infrastructure -- Introduction to informatics and nursing -- Non-AI decision making -- Medical informatics and biomedical emergencies: new training and simulation technologies for first responders -- sect. V. Biomedical sensors. Physical measurements -- Biopotential electrodes -- Electrochemical sensors -- Optical sensors -- Bioanalytic sensors -- Biological sensors for diagnostics -- sect. VI. Medical instruments and devices. Biopotential amplifiers -- Bioelectric impedance measurements -- Implantable cardiac pacemakers --Medical instruments and devices used in the home -- Virtual instrumentation: applications in biomedical engineering -- sect. VII. Clinical engineering. Clinical engineering: evolution of a discipline -- Management and assessment of medical technology -- Risk factors, safety, and management of medical equipment -- Clinical engineering program indicators -- Quality of improvement and team building -- A standards primer for clinical engineers -- Regulatory and assessment agencies -- Applications of virtual instruments in health care -- sect. VIII. Ethical issues associated with the use of medical technology. Beneficence, nonmaleficence, and medical technology -- Ethical issues related to clinical research.Noninvasive arterial blood pressure and mechanics -- Cardiac output measurement -- External defibrillators -- Implantable defibrillators -- Implantable stimulators for neuromuscular control -- Respiration -- Mechanical ventilation -- Essentials of anesthesia delivery -- Electrosurgical devices -- Biomedical lasers -- Instrumentation for cell mechanics -- Blood glucose monitoring -- Atomic force microscopy: probing biomolecular interactions -- Parenteral infusion devices -- Clinical laboratory: separation and spectral methods -- Clinical laboratory: nonspectral methods and automation -- Noninvasive optical monitoring --Sect. I. Biomedical signal analysis. Biomedical signals: origin and dynamic characteristics, frequency-domain analysis -- Digital biomedical signal acquisition and processing -- Compression of digital biomedical signals -- Time-frequency signal representations for biomedical signals -- Wavelet (time-scale) analysis in biomedical signal processing -- Higher-order spectral analysis -- Neural networks in biomedical signal processing -- complexity, scaling, and fractals in biomedical signals -- Future directions: biomedical signal processing and networked multimedia communications -- sect. II. Imaging. X-ray -- Computed tomography -- Magnetic resonance imaging -- Nuclear medicine -- Ultrasound -- Magnetic resonance microscopy -- Positron-emission tomography (PET) -- Electrical impedance tomography -- Medical applications of virtual reality technology --Sect. III. Infrared imaging. Advances in medical infrared imaging -- The historical development of thermometry and thermal imaging in medicine -- Physiology of thermal signals -- Quantitative active dynamic thermal IR-imaging and thermal tomography in medical diagnostics -- Thermal texture maps (TTM): concept, theory, and applications -- IR imagers as fever monitoring devices: physics, physiology, and clinical accuracy -- Infrared imaging of the breast - an overview -- Functional infrared imaging of the breast: historical perspectives, current applications, and future considerations -- Detecting breast cancer from thermal infrared images by asymmetry analysis -- Advanced thermal image processing -- Biometrics: face recognition in thermal infrared -- Infrared imaging for tissue characterization and function -- Thermal imaging in diseases of the skeletal and neuromuscular systems -- Functional infrared imaging in clinical applications -- Thermal imaging in surgery --
  • In addition to being essential for safe and effective patient care, medical equipment also has significant impact on the income and, thus, vitality of healthcare organizations. For this reason, its maintenance and management requires careful supervision by healthcare administrators, many of whom may not have the technical background to understand all of the relevant factors. This book presents the basic elements of medical equipment maintenance and management required of healthcare leaders responsible for managing or overseeing this function. It will enable these individuals to understand their professional responsibilities, as well as what they should expect from their supervised staff and how to measure and benchmark staff performance against equivalent performance levels at similar organizations. The book opens with a foundational summary of the laws, regulations, codes, and standards that are applicable to the maintenance and management of medical equipment in healthcare organizations. Next, the core functions of the team responsible for maintenance and management are described in sufficient detail for managers and overseers. Then the methods and measures for determining the effectiveness and efficiency of equipment maintenance and management are presented to allow performance management and benchmarking comparisons. The challenges and opportunities of managing healthcare organizations of different sizes, acuity levels, and geographical locations are discussed. Extensive bibliographic sources and material for further study are provided to assist students and healthcare leaders interested in acquiring more detailed knowledge.
  • Medical image registration 2001, CRCnetBASE
  • MEMS Handbook. 2nd ed. v. 1-3, 2006., CRCnetBASE
    v. 2, 2006 CRCnetBASE
    v. 3, 2006 CRCnetBASE
    [v. 1]. MEMS, introduction and fundamentals -- [v. 2]. MEMS, design and fabrication -- [v. 3]. MEMS, applications.
  • v. 2 CRCnetBASE
    [v. 1.] Fundamentals -- [v. 2.] Tools and applications.
  • Machine generated contents note: 1 Introduction -- Modeling and Simulation Issues -- Modeling and Simulation Needs -- Computational Architectures for MEFS -- Hierarchical Modeling and Simulation -- Advanced Hierarchical Design Methodology -- Hierarchical Design and Simulation Optimization -- System Design Language Uniformity -- Overview -- 2 Hierarchical Modeling -- MEFS Dynamic Modeling and Simulation at Circuit Level -- Classification of Dynamic System Models -- Fundamental Variables -- Relationships between Fundamental Variables -- Kirchhoffian Networks -- The Equivalent Circuit Modeling Method -- MEFS System-level Modeling and Simulation -- MEFS System-level Modeling -- MEFS System-level Simulation -- Statistical Analysis Capacity -- Conclusion -- 3 SystemC-based Hierarchical Design Environment -- Suitability of Modeling Languages for Hierarchical Design -- VHDL-AMS Suitability for Circuit-level Modeling and Sim- -- ulation -- VHDL Suitability for System-level Modeling and Simula- -- tion -- Performance Language-SLAM -- C/C++ and Matlab -- SystemC -- Building Design Environment with SystemC -- Hierarchical Design Environment -- System-level Modeling Package -- Circuit-level Component Modeling Package -- Numerical Simulation Package -- Optimization/Verification Package -- Conclusion -- 4 System-level Simulation and Performance Evaluation -- MEFS Computing and Architecture -- Architectural Concepts -- Architecture Proposal -- Reconfigurable Architectural Functional Requirements -- Potential Architecture -- Performance Modeling and Simulation -- Hierarchical Modeling and Simulation Methodology -- MEFS Hierarchical Perspective -- Hierarchical Performance Evaluation Strategy -- Modeling and Simulation Language -- Micro-Chemical Handling System -- Stochastic Performance Modeling -- Thermal Catalyzing Process Functionality -- Microvalve Lumped-element Nodal Modeling -- System Performance Analysis and Design Optimization -- Architectural Optimization -- Microsystem Performance Sensitivity Analysis -- Microsystem Performance Estimation with Traffic Variation -- Conclusion -- 5 Circuit-level Optimization -- Simulation Design Methodology -- Bootstrap Method -- Factorial Design -- Optimization Verification -- Subjective Verification -- Objective Verification -- On-target Design Optimization -- Statistical Modeling and Response Analyses -- Statistical Modeling of a Microvalve -- Search for On-target Design Point -- Sensitivity Analysis -- Robust Design Optimization -- Statistical Response Analysis -- Statistical Response Analysis of Microresonators -- Design Optimization of Microvalves -- Application Flexibility Optimization -- Design Approach -- Determining the Performance Flexibility -- Optimization Procedure -- Case Study: Microvalve Modeling and Optimal Design -- Conclusion -- 6 Performance Evaluation -- Introduction -- Polymerase Chain Reaction (PCR) -- PCR Detection for DNA Concentration -- PCR Purification -- Acquisition Assumption -- Continuous-flow PCR System -- Three-way Microvalve -- Sequential Continuous-flow PCR System -- Detectable PCR System -- Reconfigurable PCR System -- Droplet-based PCR System -- A Droplet-based PCR System -- Physical Implementation -- Comparison between Continuous-flow PCR and Droplet PCR -- System Design Complexity -- Performance Evaluation -- Scheduling of Microfluidic Operations for Reconfigurable Two-Dimensional -- Electrowetting Arrays -- Introduction -- Two-dimensional Electrowetting Array -- Schedule Optimization -- Droplet-based PCR Systems -- 7 Conclusion -- A VHDL Queuing Model -- B Hierarchical Environment with SystemC -- References -- Index.
  • There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, early models of saccades and smooth pursuit are presented. The smooth pursuit system allows tracking of a slow moving target to maintain its position on the fovea. Models of the smooth pursuit have been developed using systems control theory, all involving a negative feedback control system that includes a time delay, controller and plant in the forward loop, with unity feedback. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The oculomotor plant consists of three muscle pairs and the eyeball. A number of oculomotor plant models are described here beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th order oculomotor plant model. The work presented here is not an exhaustive coverage of the field, but focused on the interests of the author. In Part II, a state-of-art model of the saccade system is presented, including a neural network that controls the system.
  • There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The control of saccades is initiated by the superior colliculus and terminated by the cerebellar fastigial nucleus, and involves a complex neural circuit in the mid brain. This book is the second part of a book series on models of horizontal eye movements.
  • ch. 1. General concepts -- ch. 2. Fundamental principles of electron and energy transfer -- ch. 3. Wires and related systems -- ch. 4. Switching electron- and energy-transfer processes -- ch. 5. Light-harvesting antennae -- ch. 6. Photoinduced charge separation and solar energy conversion -- ch. 7. Bistable systems -- ch. 8. Multistate-multifunctional systems -- ch. 9. Logic gates -- ch. 10. Basic principles of molecular machines -- ch. 11. Spontaneous mechanical-like motions -- ch. 12. Movements related to opening, closing, and translocation functions -- ch. 13. Rotary movements -- ch. 14. Threading-dethreading movements -- ch. 15. Linear movements -- ch. 16. Motions in catenanes.
  • My NCBI help documentation 2005, NCBI Bookshelf
    "This book contains information on how to use My NCBI, a tool developed by the National Center for Biotechnology Information (NCBI) that replaces a previous feature called Cubby. This documentation is part of a growing collection of searchable help documents being produced for several resources available at NCBI."
  • Biomolecule/nanomaterial hybrid systems for nanobiotechnology -- Superresolution optical fluctuation imaging (SOFI) -- Application of nanoparticles for the detection and sorting of pathogenic bacteria by flow-cytometry -- Advancing nanostructured porous si-based optical transducers for label free bacteria detection -- Gold fibers as a platform for biosensing -- Surface-enhanced raman spectroscopy of organic molecules adsorbed on metallic nanoparticles -- Quantum dots and fluorescent protein FRET-based biosensors -- Semiconductor quantum dots as FRET acceptors for multiplexed diagnostics and molecular ruler application -- Assembly and microscopic characterization of DNA origami structures -- DNA nanotechnology -- Role of carbohydrate receptors in the macrophage uptake of dextran-coated iron oxide nanoparticles -- Toxicity of gold nanoparticles on somatic and reproductive cells -- Ultrasound activated nano-encapsulated targeted drug delivery and tumour cell poration -- Ultrasound mediated localized drug delivery -- Sonochemical proteinaceous microspheres for wound healing -- Alendronate liposomes for antitumor therapy: activation of [gamma] [delta] T cells and inhibition of tumor growth.
  • Molecular design of performance proteins with repetitive sequences, recombinant flagelliform spider silk as basis for biomaterials / Charlotte Vendrely, ... [et al.] -- Creation of hybrid nanorods from sequences of natural trimeric fibrous proteins by use of the fibritin trimerization motif / Katerina Papanikolopoulou, Mark J. van Raaij, Anna Mitraki -- Leucine zipper as a building block for self-assembled protein fibers / Maxim G Ryadnov, David Papapostolou, Derek N Woolfson -- Bioimimetic synthesis of bimorphic nanostructures / Joseph M. Slocik, Rajesh R. Naik -- Synthesis and primary characterization of self-assembled peptide-based hydrogels / Radhika P. Nagarkar and Joel P. Schneider -- Periodic assembly of nanospecies on repetitive DNA sequences generated on gold nanoparticles by rolling circle amplification / Weian Zhao, Michael A. Brook, Yingfu Li -- Protocols for the In Silico design of RNA nanostructures / Bruce A. Shapiro, ... [et al.] -- Self-assembly of fused homo-oligomers to create nanotubes / Idit Buch, ... [et al.] -- Computational methods in nanostructure design, replica exchange simulations of self-assembling peptides / Giovanni Bellesia, Sotiria Lampoudi, Joan-Emma Shea -- Modeling amyloid fibril formation / Maarten G. Wolf, Jeroen van Gestel, Simon W. de Leeuw -- Computer modeling in biotechnology / Aleksei Aksimentiev, ... [et al.] -- What can we learn from highly-connected ⁷-rich structures for structural interface design / Ugur Emekli, ... [et al.].
  • Neural engineering 2005, Springer
  • Neuroengineering 2008, CRCnetBASE
    Comparing electrodes for use as cortical control signals : tiny tines, tiny wires, or tiny cones on wires : which is best? / Philip R. Kennedy -- Neuromotor prosthetics : design and future directions / Mijail D. Serruya, Sung-Phil Kim, and John P. Donoghue -- Transcutaneous FES for ambulation : the parastep system / Daniel Graupe -- Development of a multifunctional 22-channel functional electrical stimulator for paraplegia / Ross Davis ... [et al.] -- An implantable bionic network of injectable neural prosthetic devices : the future platform for functional electrical stimulation and sensing to restore movement and sensation / Joseph Schulman ... [et al.] --History and overview of neural engineering / Daniel DiLorenzo and Robert E. Gross -- Cellular mechanisms of action of therapeutic brain stimulation / Zelma Kiss and Trent Anderson -- Neuromodulation : current trends in interfering with epileptic seizures / Ana Luisa Velasco ... [et al.] -- Responsive neurostimulation for epilepsy--neurosurgical experience : patient selection and implantation technique / Kostas N. Fountas and Joseph R. Smith -- Responsive neurostimulation for epilepsy : RNS technology and clinical studies / Thomas K. Tcheng and Martha Morrell -- Deep brain stimulation for pain management / Donald E. Richardson --Spinal cord stimulation for pain management / Allen W. Burton and Phillip C. Phan -- Motor cortex stimulation for pain management / Shivanand P. Lad, Kevin Chao, and Jaimie M. Henderson -- Deep brain stimulation for obsessive compulsive disorder / Wael F. Asaad and Emad N. Eskandar -- Cochlear prostheses : an introduction / Donald K. Eddington -- Visual prostheses / Robert J. Greenberg -- General clinical issues relevant to brain-computer interfaces / Eric C. Leuthardt ... [et al.] -- Implantable brain-computer interfaces : neurosurgical experience and perspective / Roy A.E. Bakay --Tapping into the spinal cord for restoring function after spinal cord injury / Lisa Guevremont and Vivian K. Mushahwar -- Theory and physiology of electrical stimulation of the central nervous system / Warren M. Grill -- Transient optical nerve stimulation : concepts and methodology of pulsed infrared laser stimulation of the peripheral nerve in vivo / Jonathan D. Wells ... [et al.] -- Transcranial magnetic stimulation of deep brain regions / Yiftach Roth and Abraham Zangen -- Application of neural plasticity for vision restoration after brain damage / Imelda Pasley ... [et al.].
  • Neuromodulation. 1st ed. v. 1-2, 2009., ScienceDirect
    Fulltext ClinicalKey
    v. 1. Section I. An introduction to neuromodulation -- Section II. Fundamentals of neuromodulation -- Section IIA. Fundamentals of neuromodulation: mechanisms -- Section III. Biomedical engineering considerations -- Section IV. Neuromodulation for chronic pain -- Section IVA. Periphery and spinal cord electrical stimulation for non-visceral pain -- Section IVB. Infusional therapies for pain -- Section IVC. Brain stimulation for painv. 2. Section V. Neuomodulation for movement disorders -- Section VI. Neurostimulation for epilepsy -- Section VII. Neuromodulation for psychiatric disorders -- Section VIII. Neuromodulation for functional restoration -- Section IX. Neuromodulation of body organs -- Section IXA. Neuromodulation for cardiovascular disorders -- Section IXB. Neuromodulation for gastrointestinal disorders -- Section IXC. Neuromodulation for urogenital disorders -- Section X. Neuromodulation for emerging applications -- Section XI. Neuromodulation device implant techniques.
  • Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
  • "This book is focused on the optical techniques that can be applied to regenerative medicine, including optical coherence tomography, acousto-optic imaging, Raman spectroscopy, machine vision, polarized light imaging, fibre optic sensors, second harmonic generation, multi-photon microscopy, coherent anti-Stokes Raman scattering, and polarized light imaging. It covers applications both in fundamental research and in the regenerative medicine industry for tissue engineering products. Each chapter gives an overview of a particular technique, its advantages and limitations in terms of structural and functional information provided, and examples of applications in regenerative medicine. The book provides a practical guide to the most appropriate techniques for a given application. It also offers a summary of major recent advances, such as use of machine vision for tracking growth of three-dimensional constructs in bioreactors and polarization sensitive optical coherence tomography for monitoring collagen alignment in cartilage growth"--Provided by publisher.
  • Dentists are routinely faced with a huge choice of implant systems from different manufacturers, each of whom claims that its own particular system has advantages over the others. There is consequently a need for an evidence-based review of the field that offers authoritative practical guidance for dental practitioners. Oral and Cranial Implants: Recent Research Developments has been written with this in mind. It brings together all the recent key developments in implant research and discusses the underlying science relating to implant procedures and failures.
  • Forces and equilibrium -- Deformation -- Mechanical properties -- Viscoelasticity -- Properties of natural materials -- Polymers -- Metals -- Ceramics and composites -- Tissue engineering -- Hybrid, combination, and replant materials -- Friction and wear -- Corrosion and degradation -- Fixation -- Host response -- Testing and introduction of new materials -- Materials retrieval and analysis -- Self-test.
  • The most comprehensive physical therapy text available on the topic, Orthotics & Prosthetics in Rehabilitation, 3rd Edition, is your one-stop resource for clinically relevant rehabilitation information. Evidence-based coverage offers essential guidelines on orthotic/prosthetic prescription, pre- and post-intervention gait assessment and outcome measurement, and working with special populations. Whether you are a student or a clinician, this text provides the strong foundation in and appreciation for the field of orthotics and prosthetics that will give you the critical skills needed when working with this unique client population. Inside you'll find: comprehensive coverage of rehabilitation in a variety of environments, including acute care, long-term care, home health care, and outpatient settings; authoritative information from the Guide to Physical Therapist Practice, 2nd edition is incorporated throughout to keep you up to date with the recognized standard in the field; WHO International Classification of Function model provides consistent language and an international standard to describe and measure health and disability from a biopsychosocial perspective; case studies present real-life scenarios that demonstrate how key concepts apply to clinical decision making and evidence-based practice; and a visually appealing 2-color design and a wealth of tables and boxes highlight vital information for quick reference and ease of use. New to this edition: NEW! Chapter on athletics after amputation exploring advanced training and athletics, including running and athletic competition, to enhance the quality of life for persons with amputation; NEW! Chapter on the high risk foot and wound healing helps you recognize, treat, and manage wounds for the proper fit and managemnt of the patient; NEW! Chatper on advanced prosthetic rehabilitation provides more thorough rehabilitation methods beyond the early care of persons learning to use thier prostheses; updated photos and illustration reflect current clinical practice; and updated chapters covering assessment of gait with a focus on clinically useful outcome measures, motor control and motor learning incorporating new insights into neuroplasticity and functional recovery, and a NEW integrated chapter on lower extremity orthoses that assist in clincial decision making about the best options for your patients.
  • Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.
  • The Poincaré plot (named after Henri Poincaré) is a popular two-dimensional visualization tool for dynamic systems due to its intuitive display of the dynamic properties of a system from a time series. This book presents the basis of Poincaré plot and focus especially on traditional and new methods for analysing the geometry, temporal and spatial dynamics disclosed by the Poincaré plot to evaluate heart rate variability (HRV). Mathematical descriptors of Poincaré plot have been developed to quantify the autonomic nervous system activity (sympathetic and parasympathetic modulation of heart rate). Poincaré plot analysis has also been used in various clinical diagnostic settings like diabetes, chronic heart failure, chronic renal failure and sleep apnea syndrome. The primary aims of quantification of the Poincaré plots are to discriminate healthy physiological systems from pathological conditions and to classify the stage of a disease. The HRV analysis by Poincaré plot has opened up ample opportunities for important clinical and research applications. Therefore, the present book can be used either for self-study, as a supplement to courses in linear and nonlinear systems, or as a modern monograph by researchers in this field of HRV analysis.
  • Part I. Polymers as Biomaterials -- 1. Polysaccharides as Biomaterials / Severian Dumitriu -- 2. Biomimetics / Weiyuan John Kao -- 3. Silicones for Pharmaceutical and Biomedical Applications / Haissam S. El-Zaim and John P. Heggers -- 4. Biodegradable Polymers as Drug Carrier Systems / Abraham J. Domb, Neeraj Kumar, Tzviel Sheskin, Alfonso Bentolila, Joram Slager, and Doron Teomim -- 5. Biodegradable Biomaterials Having Nitric Oxide Biological Activity / C.C. Chu -- 6. Hydrogels for Biomedical and Pharmaceutical Applications / Akio Kishida and Yoshito Ikada -- 7. Mucoadhesive Polymers / Andreas Bernkop-Schnürch -- 8. Polymers for Tissue Engineering Scaffolds / Howard W.T. Matthew -- 9. Chitosan: Structure-Properties Relationship and Biomedical Applications / Alain Domard and Monique Domard -- 10. Chitosan-Based Delivery Systems: Physicochemical Properties and Pharmaceutical Applications / Radi Hejazi and Monsoor Amiji -- 11. Immobilization of Active Biopolymers from Cold Plasma-Functionalized Surfaces for the Creation of Molecular Recognition and Molecular Manufacturing Systems / Ferencz Denes and Sorin Manolache -- 12. Advances in Designed Multivalent Bioconjugates with Dendritic Structure / Bogdan Comanita -- 13. Biocompatibility of Elastomers / D.J. Chauvel-Lebret, P. Auroy, and M. Bonnaure-Mallet -- 14. Control of Cell-Biomaterial Interactions / Danielle C. Giliberti, Kyle K. White, and Kay C Dee -- Part II. Medical and Pharmaceutical Applications of Polymers -- 15. Polymeric Systems for Ophthalmic Drug Delivery / O. Felt, S. Einmahl, P. Furrer, V. Baeyens, and R. Gurny -- 16. Dental and Maxillofacial Surgery Applications of Polymers ? A. Bascones, J. M. Vega, N. Olmo, J. Turnay, J.G. Gavilanes, and M.A. Lizarbe -- 17. Biomaterials in Bum and Wound Dressings / Robert L. Sheridan, Jeffrey R. Morgan, and Rashid Mohammad -- 18. Dermocosmetic Applications of Polymeric Biomaterials / P. Corvi Mora and P.G. Baraldi -- 19. Textile-Based Biomaterials for Surgical Applications / C.C. Chu -- 20. Bioabsorbable Polymers for Medical Applications with an Emphasis on Orthopedic Surgery / Pentti U. Rokkanen -- 21. Polymers for Artificial Joints / Naohide Tomita, Kazuya Nagata, and Hiroshi Fujita -- 22. Polymeric Occluders in Tilting Disc Heart Valve Prostheses / G.S. Bhuvaneshwar, A.V. Ramani, and K.B. Chandran -- 23. Blood-Contacting Polymers / T. Avramoglou, J. Jozefonvicz, and M. Jozefowicz -- 24. Surface Modification of Dacron Vascular Grafts: Incorporation of Antithrombin and Mitogenic Properties / Matthew D. Phaneuf Martin J. Bide, William C. Quist, and Frank W. LoGerfo -- 25. Antithrombin-Heparin Complexes / Leslie R. Berry, Maureen Andrew, and Anthony K.C. Chan -- 26. Adhesives for Medical Applications / lain Webster and Peter J. West -- 27. Glucose-Sensitive Hydrogel Membranes / Jin Ho Lee, Jung Ju Kim, and Kinam Park -- 28. Polymeric Micro- and Nanoparticles as Drug Carriers / G. Barratt, G. Couarraze, P. Couvreur, C. Dubernet, E. Fattal, R. Gref, D. Labarre, P. Legrand, G. Ponchel, and C. Vauthier -- 29. Liposomes in Drug Delivery / Yuan-Peng Zhang, Boris Ceh, and Danilo D. Lasic -- 30. Liposomes for Cancer Therapy Applications / Lawrence D. Mayer, Rajesh Krishna, and Marcel B. Bally -- 31. Systemic Cancer Therapy Using Polymer-Based Prodrugs and Progenes / Leonard W. Seymour -- 32. Anticancer Drug Conjugates with Macromolecular Carriers / F. Kratz, A. Warnecke, K. Riebeseel, and P.C.A. Rodrigues -- 33. Enzyme-Prodrug Therapies of Cancer / Richard J. Knox, Roger G. Melton, and Ronit Satchi -- 34. New Lipid/DNA Complexes for Gene Delivery / Kenneth W. Liang and Leaf Huang -- 35. Gene Delivery by Cationic Liposome-DNA Complexes / Nejat Düzgüneş, Sérgio Simões, Pedro Pires, and Maria C. Pedroso de Lima -- 36. Biological Stimulus-Responsive Hydrogels / Takashi Miyata and Tadashi Uragami -- 37. Biocompatible Polymers in Liver-Targeted Gene Delivery Systems / Edwin C. Ouyang, George Y. Wu, and Catherine H. Wu -- 38. Bioartificial Pancreas / Riccardo Calafiore -- 39. Transdermal Delivery of Drugs / B.B. Michniak and A. El-Kattan -- 40. Drug Delivery via Mucosal Routes / Nimit Worakul and Joseph R. Robinson -- 41. Bioadhesive Drug Delivery Systems / A. David Woolfson, R. Karl Malcolm, Paul A. McCarron, and David S. Jones -- 42. Recent Developments in Drug Delivery to the Nervous System -- Dusica Maysinger, Radoslav Savic, Joseph Tam, Christine Allen, and Adi Eisenberg -- 43. Glucose-Mediated Insulin Delivery from Implantable Polymers / Larry R. Brown -- 44. Drug Targeting to the Kidney: The Low-Molecular-Weight Protein Approach / R.F.G. Haverdings, R.J. Kok, M. Haas, F. Moolenaar, D. de Zeeuw, and D.K.F. Meijer.
  • "In a carefully crafted, multidisciplinary, skillfully focused format, this book covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. It features small, readable monographs that provide a brief description of the evolving role of a particular material, and present topics in highly integrated, well-balanced, authoritatively prepared segments on materials processing and in vitro and in vivo evaluation, complete with case studies"--Provided by publisher.
  • 1. Introductory concepts -- 2. Single channel (univariate) signal -- 3. Multiple channels (multivariate) signals -- 4. Application to biomedical signals.
  • Fulltext ClinicalKey
    Chapter 1. Molecular Organization of Cells / Jon D. Ahlstrom -- Chapter 2. Cell-ECM Interactions in Repair and Regeneration / M. Petreaca, M. Martins-Green -- Chapter 3. Mechanisms of Blastema Formation in Regenerating Amphibian Limbs / David L. Stocum, Nandini Rao -- Chapter 4. The Molecular Circuitry Underlying Pluripotency in Embryonic Stem Cells and iPS Cells / Harvir Singh, Ali H. Brivanlou -- Chapter 5. How Cells Change their Phenotype / Caroline Beth Sangan, David Tosh -- Chapter 6. Scarless Wound Healing / Allison Nauta, Barrett Larson, Michael T. Longaker, H. Peter Lorenz -- Chapter 7. Somatic Cloning and Epigenetic Reprogramming in Mammals / Heiner Niemann, Wilfried A. Kues, Andrea Lucas-Hahn, Joseph W. Carnwath -- Chapter 8. Engineered Proteins for Controlling Gene Expression / Charles A. Gersbach -- Chapter 9. Genetic Approaches in Human Embryonic Stem Cells and their Derivatives: Prospects for Regenerative Medicine / Junfeng Ji, Bonan Zhong, Mickie Bhatia -- Chapter 10. Embryonic Stem Cells: Derivation and Properties / Junying Yu, James A. Thomson -- Chapter 11. Alternative Sources of Human Embryonic Stem Cells / Svetlana Gavrilov, Virginia E. Papaioannou, Donald W. Landry -- Chapter 12. Stem Cells from Amniotic Fluid / Mara Cananzi, Anthony Atala, Paolo de Coppi -- Chapter 13. Induced Pluripotent Stem Cells / Keisuke Okita, Shinya Yamanaka -- Chapter 14. MSCs in Regenerative Medicine / Arnold I. Caplan -- Chapter 15. Multipotent Adult Progenitor Cells / Philip Roelandt, Catherine M. Verfaillie -- Chapter 16. Hematopoietic Stem Cell Properties, Markers, and Therapeutics / Kuanyin K. Lin, Grant A. Challen, Margaret A. Goodell -- Chapter 17. Mesenchymal Stem Cells / Zulma Gazit, Gadi Pelled, Dima Sheyn, Nadav Kimelman, Dan Gazit -- Chapter 18. Cell Therapy of Liver Disease: From Hepatocytes to Stem Cells / Stephen C. Strom, Ewa C.S. Ellis -- Chapter 19. Cardiac Stem Cells: Biology and Therapeutic Applications / Sarah Selem, Konstantinos E. Hatzistergos, Joshua M. Hare -- Chapter 20. Skeletal Muscle Stem Cells / Benjamin D. Cosgrove, Helen M. Blau -- Chapter 21. Stem Cells Derived from Fat / Adam J. Katz, Alexander F. Mericli --Chapter 22. Peripheral Blood Stem Cells / Zhan Wang, Gunter Schuch, J. Koudy Williams, Shay Soker -- Chapter 23. Islet Cell Therapy and Pancreatic Stem Cells / Juan Domínguez-Bendala, Antonello Pileggi, Camillo Ricordi -- Chapter 24. Regenerative Medicine for Diseases of the Retina / Deepak A. Lamba, Thomas A. Reh -- Chapter 25. Somatic Cells: Growth and Expansion Potential of T Lymphocytes / Rita B. Effros -- Chapter 26. Mechanical Determinants of Tissue Development / Jonathan A. Kluge, Gary G. Leisk, David L. Kaplan -- Chapter 27. Morphogenesis of Bone, Morphogenetic Proteins, and Regenerative Medicine / A.H. Reddi -- Chapter 28. Physical Stress as a Factor in Tissue Growth and Remodeling / Joel D. Boerckel, Christopher V. Gemmiti, Yash M. Kolambkar, Blaise D. Porter, Robert E. Guldberg -- Chapter 29. Intelligent Surfaces for Cell-Sheet Engineering / Takanori Iwata, Masayuki Yamato, Teruo Okano -- Chapter 30. Applications of Nanotechnology for Regenerative Medicine / Benjamin S. Harrison, Sirinrath Sirivisoot -- Chapter 31. Design Principles in Biomaterials and Scaffolds / Hyukjin Lee, Hyun Jung Chung, Tae Gwan Park -- Chapter 32. Natural Origin Materials for Bone Tissue Engineering - Properties, Processing, and Performance / V.M. Correlo, J.M. Oliveira, J.F. Mano, N.M. Neves, R.L. Reis -- Chapter 33. Synthetic Polymers / M.C. Hacker, A.G. Mikos -- Chapter 34. Biological Scaffolds for Regenerative Medicine / Alexander Huber, Stephen F. Badylak -- Chapter 35. Hydrogels in Regenerative Medicine / Justin M. Saul, David F. Williams -- Chapter 36. Surface Modification of Biomaterials / Andrés J. García -- Chapter 37. Histogenesis in Three-dimensional Scaffolds / Melissa K. McHale, Nicole M. Bergmann, Jennifer L. West -- Chapter 38. Biocompatibility and Bioresponse to Biomaterials / James M. Anderson -- Chapter 39. Designing Tunable Artificial Matrices for Stem Cell Culture / Elizabeth F. Irwin, Jacob F. Pollock, David V. Schaffer, Kevin E. Healy -- Chapter 40. Biomineralization and Bone Regeneration / Jiang Hu, Xiaohua Liu, Peter X. Ma -- Chapter 41. Cell Therapy for Blood Substitutes / Shi-Jiang Lu, Qiang Feng, Feng Li, Erin A. Kimbrel, Robert Lanza --Chapter 42. Articular Cartilage / Lily Jeng, Francois Ng kee Kwong, Myron Spector -- Chapter 43. Myoblast Transplantation in Skeletal Muscles / Daniel Skuk, Jacques P. Tremblay -- Chapter 44. Clinical Islet Transplantation / Juliet A. Emamaullee, Michael McCall, A.M. James Shapiro -- Chapter 45. Fetal Tissues / Ryan P. Dorin, Chester J. Koh -- Chapter 46. Engineering of Large Diameter Vessels / Masood A. Machingal, Saami K. Yazdani, George J. Christ -- Chapter 47. Engineering of Small-Diameter Vessels / Brett C. Isenberg, Chrysanthi Williams, Robert T. Tranquillo -- Chapter 48. Cardiac Tissue / Milica Radisic, Michael V. Sefton -- Chapter 49. Regenerative Medicine in the Cornea / May Griffith, Per Fagerholm, Neil Lagali, Malcolm A. Latorre, Joanne Hackett, Heather Sheardown -- Chapter 50. Alimentary Tract / Richard M. Day -- Chapter 51. Extracorporeal Renal Replacement / Kimberly A. Johnston, H. David Humes -- Chapter 52. Tissue Engineering of the Reproductive System / Stefano Da Sacco, Laura Perin, Roger E. De Filippo -- Chapter 53. Cartilage Tissue Engineering / Qiongyu Guo, Jennifer H. Elisseeff -- Chapter 54. Functional Tissue Engineering of Ligament and Tendon Injuries / Savio L.-Y. Woo, Alejandro J. Almarza, Sinan Karaoglu, Rui Liang, Matthew B. Fisher -- Chapter 55. Central Nervous System / Brian G. Ballios, M. Douglas Baumann, Michael J. Cooke, Molly S. Shoichet -- Chapter 56. Peripheral Nerve Regeneration / Mahesh C. Dodla, Vivek J. Mukhatyar, Ravi V. Bellamkonda -- Chapter 57. Tissue Engineering of Skin / Fiona Wood -- Chapter 58. Regenerative Medicine of the Respiratory Tract / Martin A. Birchall, Sam Janes, Paolo Macchiarini -- Chapter 59. The Digit: Engineering of Phalanges and Small Joints / Makoto Komura, Jaehyun Kim, Anthony Atala, James J. Yoo, Sang Jin Lee -- Chapter 60. Intracorporeal Kidney Support / Jae Hyun Bae, Tamer Aboushwareb, Anthony Atala, James J. Yoo -- Chapter 61. Ethical Considerations / Ronald M. Green -- Chapter 62. US Stem Cell Research Policy / Josephine Johnston -- Chapter 63. Overview of the FDA Regulatory Process / Kevin J. Whittlesey, Mark H. Lee, Jiyoung M. Dang, Maegen Colehour, Judith Arcidiacono, Ellen Lazarus, David S. Kaplan, Donald Fink, Charles N. Durfor, Ashok Batra, Stephen L. Hilbert, Deborah Lavoie Grayeski, Richard McFarland, Celia Witten.
  • "Experimental protein engineering and computational protein design are broad but complementary strategies for developing proteins with altered or novel structural properties and biological functions. By describing cutting-edge advances in both of these fields, Protein Engineering and Design aims to cultivate a synergistic approach to protein science. The first half of the book discusses experimental approaches to protein engineering and starts by describing several high-throughput screening platforms for protein engineering. Key techniques used for diversity generation are also discussed. The next few chapters present examples of therapeutics, enzymes, biomaterials, and other proteins that have been engineered by rational or combinatorial approaches. The section finishes with a chapter on the use of non-natural amino acids in protein engineering. The second half of the book introduces computational protein design, beginning with a chapter on computational and informatics algorithms used in protein engineering. Core components of computational protein design are then discussed in detail, and examples of heuristic protein design are provided. Subsequent chapters present examples of how computational design has played a critical role in advancing the field of protein engineering. Concluding with a chapter outlining current challenges in the field, this book makes computational protein design and diversity-oriented protein engineering widely accessible to a broad audience in academia and industry alike."--Publisher's description.
  • Psychoprosthetics 2008, Springer
  • Neural anatomy -- Passive membranes -- Active membranes -- Propagation -- Neural branches -- Synapses -- Networks of neurons -- Extracellular recording and stimulation -- The neural code -- Applications.
  • Inducing embryonic stem cells to become cardiomyocytes / Alexander M. Becker, Michael Rubart, and Loren J. Field -- Regenerating function in vivo with myocytes derived from embryonic stem cells / Priya R. Baraniak and Todd C. McDevitt -- Excitation-contraction coupling, functional properties, and autonomic and hormonal regulation in human embryonic stem cell derived cardiomyocytes / Oshra Sedan and Ofer Binah -- Embryonic stem cell derivatives for cardiac therapy : advantages, limitations, and long-term prospects / Michal Weiler-Sagie and Lior Gepstein -- Methods for differentiation of bone-marrow-derived stem cells into myocytes / Shinji Makino and Keiichi Fukuda -- Homing, survival, and paracrine effects of human mesenchymal stem cells / Sergey Doronin -- Bone marrow cell therapy after myocardial infarction : what have we learned from the clinical trials and where are we going? / Kai C. Wollert -- Evidence for the existence of resident cardiac stem cells / Isotta Chimenti ... [et al.] -- Multiple sources for cardiac stem cells and their cardiogenic potential / Antonio Paolo Beltrami, Daniela Cesselli, and Carlo Alberto Beltrami -- Skeletal muscle stem cells in the spotlight : the satellite cell / Zipora Yablonka-Reuveni and Kenneth Day -- Regenerating mechanical function in vivo with skeletal myoblasts / Todd K. Rosengart and Muath Bishawi -- Methods for inducing pluripotency / Raymond L. Page, Christopher Malcuit, and Tanja Dominko -- Inducible pluripotent stem cells for cardiac regeneration / Naama Zeevi-Levin and Joseph Itskovitz-Eldor -- Induced pluripotent cells for myocardial infarction repair / Timothy J. Nelson and Andre Terzic -- Substrates of cardiac reentrant arrhythmias : the possible role of tissue regeneration and replacement / André G. Kléber -- Integration of stem cells into the cardiac syncytium : formation of gap junctions / Peter R. Brink, Ira S. Cohen, and Richard T. Mathias -- Bradyarrhythmia therapies : the creation of biological pacemakers and restoring atrioventricular node function / Richard B. Robinson -- Tachyarrhythmia therapies : approaches to atrial fibrillation and postinfarction ventricular arrhythmias / J. Kevin Donahue and Kenneth R. Laurita -- Long-term prospects for arrhythmia treatment : advantages and limitations of gene and cell therapies / Michael R. Rosen -- Regenerating blood vessels / Tracy A. Gwyther and Marsha W. Rolle -- Regenerating heart valves / Benedikt Weber and Simon P. Hoerstrup -- Tissue engineering strategies for cardiac regeneration / Amandine F.G. Godier-Furnémont ... [et al.] -- Methods of cell delivery for cardiac repair / Sarah Fernandes and Hans Reinecke -- Tracking of stem cells in vivo / Yingli Fu and Dara L. Kraitchman -- Assessing regional mechanical function after stem cell delivery / Jacques P. Guyette and Glenn R. Gaudette.
  • Frontiers of spinal cord and spine repair : experimental approaches for repair of spinal cord injury / Choya Yoon and Mark H. Tuszynski -- Stem cell based strategies for spinal cord injury repair / Alexa Reeves and Hans S. Keirstead -- Strategies for endogenous spinal cord repair : HPMA hydrogel to recruit migrating endogenous stem cells / Araceli Espinosa-Jeffrey ... [et al.] -- Stem cells and spinal cord injury repair / Soheila Karimi-Abdolrezaee and Eftekhar Eftekharpour -- Chronic pain following spinal cord injury / Radi Masri and Asaf Keller -- Repair of radiation damage and radiation injury to the spinal cord / Timothy E. Schultheiss -- Malignancies of the spinal cord / J. Dawn Waters, Encarnacion Maria Navarro Peran, and Joseph Ciacci -- Molecular basis of intervertebral disc degeneration / Dipika Gopal ... [et al.] -- Bioceramics for osteogenesis, molecular and cellular advances / Hande Demirkiran -- Cell-based therapies for spinal fusion / Ronke Olabisi -- Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering / Josh Neman ... [et al.] -- Progenitor cells : role and usage in bone tissue engineering approaches for spinal fusion / Lonnissa H. Nguyen ... [et al.].
  • Principles of regenerative medicine and cell,tissue and organ bioengineering -- Kidney -- Liver -- Heart -- Small bowel -- Endocrine pancreas and islets of langerhans -- Lung -- Composite tissues allotranplantation -- Immunosuppression-free transplantation in the regenerative medicine era.
  • A massive wastage of the global resources -- Placenta as a source of stem cells and as a key organ for fetomaternal tolerance -- Placenta and umbilical cord in traditional Chinese medicine -- Use of umbilical venous blood on assessing the biochemical variations of acid-base, nutritional and metabolic parameters on growth-retarded fetuses, in comparison with gestational control cases: a study -- Umbilical cord blood transfusion and its therapeutic potentialities -- Autologous placental blood transfusion for the therapy of anemic neonates -- Cord blood: a massive waste of a life-saving resource: a perspective on its current and potential uses -- Clinical experience of cord blood autologous transfusion -- Emergency use of human cord blood -- Hemoglobin-based oxygen carriers in trauma care: the US multicenter prehospital trial -- Placental umbilical cord blood as a true blood substitute with an edge -- Implications of feto-maternal cell transfer in normal pregnancy -- Early reports on the prognostic implications and immunotherapeutic potentials of Cd34 rich cord whole blood transfusion in advanced breast cancer with severe anemia -- Anti-inflammatory effects of human cord blood and its potential implications in neurological disorders -- Transforming "waste" into gold: identification of novel stem cells resources with therapeutic potential in neuromuscular disorders -- Human umbilical cord blood cells for stroke -- Placental umbilical cord blood transfusion for stem cell therapy in neurological diseases -- Umbilical cord and its blood: a perspective on its current and potential use in ophthalmology -- Umbilical vein grafts for lower limb revascularization -- Cord blood stem cells in angiogenesis.Endothelial progenitor cells from cord blood: magic bullets against ischemia? -- Therapeutic potential of placental umbilical cord blood in cardiology -- Stem cell therapy for heart failure using cord blood -- Human umbilical cord blood mononuclear cells in the treatment of acute myocardial infarction -- Umbilical cord-derived mesenchymal stem cells -- Cord blood stem cell expansion ex vivo: current status and future strategies -- Embryonic-like stem cells and the importance of human umbilical cord blood for regenerative medicine -- Use of non-hematopoietic stem cells of fetal origin from cord blood, umbilical cord, and placenta in regeneration medicine -- Animal studies of cord blood and regeneration -- Immune privilege of cord blood -- Combination cellular therapy for regenerative medicine: the stem cell niche -- Use of cord blood in regenerative medicine -- Comparisons between related and unrelated cord blood collection and/or banking for transplantation or research: the UK NHS blood and transplant experience -- Donor and collection-related variables affecting product quality in ex utero cord blood banking -- Cord blood as a source of hematopoietic progenitors for transplantation -- Amniotic fluid and placenta stem cells -- Use of amniotic membrane, amniotic fluid, and placental dressing in advanced burn patients -- Clinical use of amniotic fluid in osteoarthritis: a source of cell therapy -- A study and follow-up (1999-2009) of human fetal neuronal tissue transplants at a heterotopic site outside the brain in cases of advanced idiopathic Parkinsonism -- Ethical issues surrounding umbilical cord blood donation and banking.
  • Basic mathematical concepts -- Introduction to reliability technology, human error, and quality -- Medical device safety and quality assurance -- Medical device software quality assurance and risk assessment -- Medical device maintenance and sources for obtaining medical device-related failure data -- Human error in health care -- Health care human error reporting systems and models for predicting human reliability and error in health care -- Patient safety -- Introduction to quality in health care -- Quality methods for use in health care.
  • The History of Robotic Surgery -- Robotic Instrumentation and Operating Room Setup -- Port Placement in Robotic Urologic Surgery -- Achieving Efficiency in the Operating Room: Step by Step -- Laparoscopy vs. Robotics: Ergonomics -- Does It Matter? -- Anesthetic Considerations for Robotic Urologic Surgery -- The Development of a Robotic Urology Program in the UK -- Robotic Urologic Surgery: How to Make an Effective Robotic Program -- Witnessing the Transition of Open to Robotic Surgery -- Patient-Side Surgeons: The Unsung Heroes of Robotic Surgery -- Training in Robotic Urologic Surgery -- Animal Laboratory Training: Current Status and How Essential Is It? -- Training of Operating Room Technician and Nurses in Robotic Surgery -- Impact of Virtual Reality Simulators in Training of Robotic Surgery -- Training, Credentialing, and Hospital Privileging for Robotic Urological Surgery -- Research in Urologic Oncology in an Era of Minimally Invasive Surgery -- Databases and Data Management for Robotic Surgery -- The Role of Scientific Journals in Disseminating New Technology -- Predicting Robotic Utilization in Urologic Disease: An Epidemiology-Based Model -- Development of the Vattikuti Institute Prostatectomy: Historical Perspective and Technical Nuances -- Transferring Knowledge of Anatomical Dissection from the Laboratory to the Patient: An Australian Perspective -- Robot-Assisted Radical Prostatectomy: A Prostate Surgeon's Perspective -- Cautery-Free Technique of Robot-Assisted Radical Prostatectomy: Impact on Nerve Preservation and Long-Term Outcome on Recovery of Sexual Function -- Current Concepts in Cavernosal Neural Anatomy and Imaging and Their Implications for Nerve-Sparing Radical Prostatectomy -- Robot-Assisted Radical Prostatectomy for Large Glands and Median Lobe -- Extraperitoneal Robot-Assisted Radical Prostatectomy: Simulating the Gold Standard -- The Retrograde Extraperitoneal Approach: Robotic Retrograde Extraperitoneal Laparoscopic Prostatectomy (RRELP). Technical Modifications for Robotic Prostatectomy -- Robotic Radical Prostatectomy: Cancer Control and Implications of Margin Positivity -- Techniques to Improve Urinary Continence Following Robot-Assisted Radical Prostatectomy -- Penile Rehabilitation After Robotic Radical Prostatectomy: The Best Strategy -- Laparoscopy or Robotic Radical Prostatectomy: Pros and Cons -- Complications of Robotic Prostatectomy -- Robotic Urologic Surgery: Robotic-Assisted Adrenalectomy -- Robot-Assisted Laparoscopic Radical Nephrectomy and Nephroureterectomy -- Robot-Assisted Partial Nephrectomy -- Robotic Urologic Surgery: Robot-Assisted Partial Nephrectomy -- Robotic Donor Nephrectomy: Technique and Outcomes -- An European Perspective -- Robot-Assisted Laparoscopic Pyeloplasty -- Robotic Surgery for Urolithiasis -- Ureteral Reconstruction Utilizing Robotic-Assisted Techniques -- Robotic or Laparoscopic Renal Surgery: Pros and Cons -- Robot-Assisted Radical Cystectomy in Male: Technique of Spaces -- Robotic-Assisted Laparoscopic Anterior Pelvic Exenteration for Bladder Cancer in the Female -- Robotic-Assisted Laparoscopic Extended Pelvic Lymph Node Dissection for Bladder Cancer -- Robot-Assisted Intracorporeal Ileal Conduit -- Robotic Urinary Diversion: Technique, Current Status, and Outcomes -- Robotic Bladder Surgery Complications: Prevention and Management -- Robotic Surgery for Ureteral Anomalies in Children -- Robotic Surgery of the Kidney in Children -- Robotic Bladder Surgery in Children -- Robotic Surgery in Urogynecology -- Robotic Repair of Vesico-vaginal Fistula -- Robotic Surgery in Male Infertility (Robotic-Assisted Microsurgery) -- Treater to Target: Experiences of a Prostate Cancer Participant -- My Prostate Cancer -- Telementoring and Telesurgery in Urology -- Robotic Systems: Past, Present, and Future.
  • 1. Introduction -- I. Biocompatibility -- II. Scope of Devices and the Medical Device Market -- III. History -- IV. Nonspecific Regulatory Considerations -- 2. Regulatory Aspects and Strategy in Medical Device and Biomaterials Safety Evaluation -- I. Regulatory Basis -- II. Toxicity Testing: Medical Devices -- 3. Road Map to Test Selections -- I. Key Concepts -- II. Conditions of Use -- III. Materials, Components, and Products -- IV. Prior Knowledge -- V. Types and Uses of Tests -- 4. What to Test: Sampling and Sample Preparation -- I. Sampling -- II. Randomization -- III. Sample Preparation -- IV. Reference Materials -- V. Conclusion -- 5. Cytotoxicity Testing -- I. Background -- II. Cytotoxicity Assays -- III. Conclusion -- 6. Blood Compatibility -- I. Introduction -- II. Standard Tests -- III. Conclusion -- 7. Irritation and Pyrogenicity -- I. Dermal Irritation -- II. Ocular Irritation Testing -- III. Other Nonparenteral Route Irritation Tests -- IV. Parenteral Irritation/Tolerance -- V. Parenteral Routes -- VI. Intracutaneous Irritation -- VII. Problems in Testing (and Their Resolutions) -- 8. Immunotoxicology -- I. Overview of the Immune System -- II. Evaluation of the Immune System -- III. Local Lymph Node Assay -- IV. Approaches -- V. Problems and Future Directions -- 9. Implantation Biology and Studies -- I. USP Implantation Test -- II. British Pharmacopoeia -- III. ISO 10993 Implantation Test -- IV. Test Method for Implantation in Subcutaneous Tissue -- V. Test Method for Implantation in Muscle -- VI. Test Method for Implantation in Bone -- VII. Control Materials -- VIII. Long-Term Implant Studies -- IX. Considerations -- 10. Genotoxicity -- I. DNA Structure -- II. Cytogenetics -- III. In Vitro Cytogenetic Assays -- IV. In Vivo Cytogenetic Assays -- V. Sister Chromatid Exchange Assays -- 11. Subchronic and Chronic Toxicity and Reproductive and -- Developmental Toxicity -- I. Objectives -- II. Regulatory Considerations -- III. Parameters to Measure -- IV. Histopathology -- V. Study Interpretation and Reporting -- VI. Reproductive and Developmental Toxicity -- 12. Carcinogenicity -- I. Animal Model -- II. Dose Selection -- III. Interpretation of Results -- 13. Sterility, Sterilization, and Heavy Metals -- I. Sterility -- II. Heavy Metals -- 14. Combination Devices -- I. Combination Products -- II. Device Programs that CDER and CBRH Will Administer -- 15. Clinical Studies for Medical Devices -- I. Design Considerations -- II. Epidemiology -- III. Conclusion -- 16. Special Studies -- I. Cardiovascular Devices and Prostheses -- II. Tampons -- III. Contact Lenses and Their Solutions -- IV. Specific Tests -- V. Twenty-One-Day Eye Irritation Study in Rabbits -- VI. Systemic Injection Test -- VII. Production of Toxic Shock Syndrome Toxin-l (TSST-1) -- VIII. In Vitro Evaluation of the Effects of Potential Tampon -- Materials on pH and Growth of Vaginal Microflora -- IX. Inflammatory Responses to Biomaterials -- 17. Case Histories and Problem Resolution -- I. Phthalate and Other Residuals Leaching from Devices -- II. Dalkon Shield -- III. Talc on Gloves and Condoms -- IV. Toxic Shock Syndrome -- V. Latex Allergy -- VI. Silicones in Devices -- VII. Problem Solving -- VIII. Risk Assessments -- IX. Conclusion -- Appendix A. Selected Regulatory and Toxicological Acronyms -- and Abbreviations -- Appendix B. Contract Testing Laboratories -- Appendix C. Notable Regulatory Internet Addresses -- Appendix D. Non-U.S. Medical Device Regulators.
  • Smart biosensor technology 2007, CRCnetBASE
  • Ventricular remodeling in ischemic cardiomyopathy / Stefan Klotz and Daniel Burkhoff -- Myocardial regeneration: which cell and why / Elmostafa El Fahime and Jacques Tremblay -- Cardiac stem cells for myocardial regeneration / Bernardo Nadal-Ginard and Simón Méndez-Ferrer -- A historic recapitulation of myoblast transplantation / Daniel Skuk and Jacques Tremblay -- Myoblast cell transplantation preclinical studies / Doris A. Taylor and Harald Ott -- Skeletal myoblasts: the European experience / Philippe Menasche -- Skeletal myoblasts: the U. S. experience / Edward B. Diethrich -- Progenitor cells for cardiac regeneration / Ana Sánchez and Javier Garcia-Sancho -- Bone marrow derived stem cell for myocardial regeneration: preclinical experience / Bradley Martin and Mark Pittenger --Bone marrow derived stem cell for myocardial regeneration: clinical experience, surgical delivery / Manual Galiñanes -- Autologous mononuclear bone marrow cell transplantation for myocardial infarction: the German experience / Michael Brehm, Tobias Zeus and Bodo E. Strauer -- Autologous mononuclear bone marrow cell transplantation for myocardial infarction: the Spanish experience / Francisco E. Avilés ... [et al.] -- Mobilizing bone marrow stem cells for myocardial repair after acute myocardial infarction / Steve Ellis and Oussama Wazni -- Percutaneous myoblast transplantation: steps in transplantation research / Nabil Dib -- A porcine model of myocardial infarction for evaluation of cell transplantation / Nabil Dib ... [et al.] -- Tissue engineering for myocardial regeneration / Ravi K. Birla -- The role of pet scan in stem cell therapy / Uchechukwa Sampson ... [et al.] -- The measurement of systolic function in the mammalian heart / Blasé Carabello -- Electrophysiological aspects of cell transplantation / Nicholas S. Peters, Nicolas A.F. Chronos and Fernando Tondato -- Regulatory considerations in manufacturing, product testing, and preclinical development of cellular products for cardiac repair / Ellen Areman, Kim Benton and Richard McFarland.
  • In vitro experimentation and research tools -- Tissue engineering and regenerative medicine.
  • pt. 1. Stem cell biology -- pt. 2. Epigenetic and microRNA regulation in stem cells -- pt. 3. Stem cells for therapeutic applications -- pt. 4. Nuclear reprogramming and induced pluripotent stem cells -- pt. 5. Tissue engineering -- pt. 6. Regenerative medicine.
  • Use of Human Embryonic Stem Cells in Therapy -- Human Neural Stem Cell-based Cell- and Gene-therapy for Neurological Diseases -- Vascular Stem Cell Therapy -- Bioprocessing of Human Pluripotent Stem Cells for Cell Therapy Applications -- Blood Cell Bioprocessing: The Haematopoietic System and Current Status of In-vitro Production of Red Blood Cells -- Bioprocessing Challenges Associated with the Purification of Cellular Therapies -- Separation Technologies for Stem Cell Bioprocessing.
  • Stem cells for myocardial repair and regeneration : where are we today? / Randall J. Lee -- Bone marrow-derived endothelial progenitor cells : isolation and characterization for myocardial repair / Masaaki Ii -- Umbilical cells stem cells for myocardial repair and regeneration / Nicholas Greco and Mary J. Laughlin -- Isolation of resident cardiac progenitor cells by Hoechst 33342 staining / Otmar Pfister ... [et al.] -- Mesenchymal stem cell therapy for cardiac repair / Andrew J. Boyle, Ian K. McNiece, and Joshua M. Hare -- Methods for human embryonic stem cells derived cardiomyocytes cultivation, genetic manipulation, and transplantation / Gil Arbel ... [et al.] -- Experimental cell transplantation therapy in rat myocardial infarction model including nude rat preparation / Wangde Dai and Robert A. Kloner -- Large animal model of heart failure for assessment of stem cells / Sharad Rastogi -- Histopathologic assessment of myocardial regeneration / Naima Carter-Monroe ... [et al.] -- Assessment of myocardial angiogenesis and vascularity in small animal models / Matthew L. Springer -- Superparamagnetic iron oxide labeling of stem cells for MRi tracking and delivery in cardiovascular disease / Dorota A. Kedziorek and Dara L. Kraitchman -- Embryonic stem cell biology : insights from molecular imaging / Karim Sallam and Joseph C. Wu -- Genetic fate-mapping for studying adult cardiomyocyte replenishment after myocardial injury / Sunny S.-K. Chan ... [et al.] -- In vitro electrophysiological mapping of stem cells / Seth Weinberg, Elizabeth A. Lipke, and Leslie Tung -- Assessment of cardiac conduction : basic principles of optical mapping / Chunhua Ding and Thomas H. Everett IV -- Surface patterning for generating defined nanoscale matrices / Karen L. Christman and Heather D. Maynard.
  • Technology is essential to the delivery of health care but it is still only a tool that needs to be deployed wisely to ensure beneficial outcomes at reasonable costs. Among various categories of health technology, medical equipment has the unique distinction of requiring both high initial investments and costly maintenance during its entire useful life. This characteristic does not, however, imply that medical equipment is more costly than other categories, provided that it is managed properly. The foundation of a sound technology management process is the planning and acquisition of equipment, collectively called technology incorporation. This lecture presents a rational, strategic process for technology incorporation based on experience, some successful and many unsuccessful, accumulated in industrialized and developing countries over the last three decades. The planning step is focused on establishing a Technology Incorporation Plan (TIP) using data collected from an audit of existing technology, evaluating needs, impacts, costs, and benefits, and consolidating the information collected for decision making. The acquisition step implements TIP by selecting equipment based on technical, regulatory, financial, and supplier considerations, and procuring it using one of the multiple forms of purchasing or agreements with suppliers. This incorporation process is generic enough to be used, with suitable adaptations, for a wide variety of health organizations with different sizes and acuity levels, ranging from health clinics to community hospitals to major teaching hospitals and even to entire health systems. Such a broadly applicable process is possible because it is based on a conceptual framework composed of in-depth analysis of the basic principles that govern each stage of technology lifecycle. Using this incorporation process, successful TIPs have been created and implemented, thereby contributing to the improvement of healthcare services and limiting the associated expenses.
  • Systems biology 2007, Springer
  • Preface / Christoph Wittmann and Sang Yup Lee -- 1. Genome-scale network modeling / Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth, and Bernhard Ø. Palsson -- 2. Kinetic modeling of metabolic networks / Daniel C. Zielinski and Bernhard Ø. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis / Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, and Hiroshi Shimizu -- 4. Technologies for bio-systems engineering / Sonja Billerbeck, Sven Dietz, Gaspar Morgado, and Sven Panke -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals / Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, and Sang Yup Lee -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels / Judith Becker, Stefanie Kind, and Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites / Eleftherios T. Papoutsakis and Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum / I. Emrah Nikerel, Peter J.T. Verheijen, Walter M. van Gulik, and Joseph J. Heijnen -- 9. Bridging omics technologies with synthetic biology in yeast industrial biotechnology / António Roldão, Il-Kwon Kim, and Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering / Tomohisa Hasunuma, Fumio Matsuda, and Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism / Paulo A. Gameiro, Christian M. Metallo, and Gregory Stephanopoulos.
  • "This reference covers clinical and bioengineering aspects of muscle reinnervation, a popular new technique at the boundary of biomedical and rehabilitation engineering and neuroscience. With contributions from pioneers in the field, the book provides a review of muscle reinnervation from a biomedical engineering and clinical perspective. It describes neuroscience and other related neuroprosthetic techniques. A companion website offers a wide range of videos and multimedia material to aid in comprehension and application"--Provided by publisher.
  • Conducted electrical weapons: a user's perspective / Greg Meyer -- The scientific history / Robert A. Stratbucker -- Conducted electrical weapons and resolution of use-of-force encounters / Charles Mesloh, Mark Henych, and Ross Wolf -- Nonlethal weapons: the broader context / Peter J. Cuenca and John G. McManus -- Transcutaneous muscle stimulation / James D. Sweeney -- Current flow in the human body / Dorin Panescu and Robert A. Stratbucker -- Animal studies / John G. Webster -- CEW research models: animal and human studies / Theodore C. Chan and Gary M. Vilke -- Cardiac arrhythmias / Derek J. Dosdall and Raymond E. Ideker -- Electrocardiographic effects of the CEW / Jeffrey D. Ho -- Serum and skin effects of CEW application / Jeffrey D. Ho -- Electrocardiographic effects of the CEW / Robert Reardon -- Rhabdomyolysis / Ronald Moscati and Samuel Cloud -- Effects of CEWs on respiration / Donald M. Dawes -- Neuroendocrine effects of CEWs / Donald M. Dawes and Mark W. Kroll -- Electroporation of cardiac and nerve cells / Vadim V. Fedorov, Leonid Livshitz, Geran Kostecki, and Igor R. Efimov -- Eye and head injuries / S. Robert Witherspoon, Andreas K. Lauer, and Jonathan L. Marinaro -- CEW effects with illegal stimulant intoxication / Patrick Tchou -- Alcohol and the CEW / Ronald Moscati and Jeffrey D. Ho -- Conducted electrical weapons and implantible cardiac devices / Subba Reddy Vanga, James L. Vacek. Loren Berenhom and Dhanunjaya R. Lakkireddy -- Risk management and the CEW / Greg Bingham -- The New York City experience / Michael D. White and Justin Ready -- Impact of CEW and other types of force and resistance on officer and suspect injuries / Michael R. Smith, Robert J. Kaminski, Jeffrey Rojek, Geoffrey P. Alpert, and James Mathis -- Field statistics overview / James E. Brewer and Mark W. Kroll -- Sudden in-custody death / Samuel J. Stratton -- Stimulant abuse and sudden cardiac death / Steven B. Karch -- The systemic role of illicit drugs and their toxicology / Joshua Gunn, Michael A. Evans, and M. Scott Kriger -- Excited delirium syndrome / Vincent J. M. Di Maio and Theresa G. Di Maio -- Biochemical brain markers in excited delirium deaths / Deborah C. Mash -- Sudden unexpected death in custody (SUDIC) / Charles V. Wetli -- Legal basics for the CEW -- Science and logic meet the law / Michael A. Brave -- Appendix A: Excited delirium checklist -- Appendix B: Electrocution diagnosis checklist.
  • Part 1.GENERAL --History of Microsurgery /Yoshikazu Ikuta --History of Telesurgery /James Wall and Jacques Marescaux --Description of Robots /Jesse Creed Selber --Instruments /Sijo Joseph Parekatti and Michael Moran --Robot Installation in Telemicrosurgery /Thierry Lequint, Kiyohito Naito, Eric Nectoux, Sybille Facca and Philippe Liverneaux --Part 2.TRAINING --Earthworms /Gustavo Mantovani Ruggiero --Vessels /Joo-Yup Lee and Alexander Y. Shin --Nerves /Stacey H. Berner --Part 3.EXPERIMENTAL RESEARCH --Free Tissue Transfer /Stacey H. Berner --Tele-endomicrosurgery /Sybille Facca, Kiyohito Naito, Thierry Lequint, Eric Nectoux and Philippe Liverneaux --Brachial Plexus Repair /Gustavo Mantovani Ruggiero and Philippe Liverneaux --Tendon Transfer /Michael S. Bednar --Part 4.CLINICAL APPLICATIONS --Nerve Entrapment /Jose Carlos Garcia Jr. --Nerve Repair /Stacey H. Berner --Brachial Plexus /Kiyohito Naito, Mickaël Ohana, Thierry Lequint, Sybille Facca and Philippe Liverneaux --Skin Flaps /Thomas Lauwers, Tom Van Mulken and Darren Booi --Muscle Flaps /Jesse Creed Selber and John C. Pedersen --Head and Neck /Jesse Creed Selber --Urology /Sijo Joseph Parekattil --Part 5.PERSPECTIVES --Supermicrosurgery /Takeshi Todokoro and Isao Koshima --Network /Catherine Jane Mohr.
  • Biomolecular engineering in oligonucleotide applications -- Gene therapy -- Bio-nanorobotics: state of the art and future challenges -- sect. IV. Bionanotechnology. DNA as a scaffold for nano-structure assembly -- Directed evolution of proteins for device applications -- Semiconductor quantum dots for molecular and cellular imaging -- Bionanotechnology for bioanalysis -- Nano-hydroxyapatite for biomedical applications -- Nanotechnology provides new tools for biomedical optics -- Nanomaterials perspectives and possibilities in nanomedicine -- Biomedical nanoengineering for nanomedicine -- Physiogenomics: integrating systems engineering and nanotechnology for personalized medicine -- Bionanotechnology patenting: challenges and opportunities -- sect. V. Tissue engineering. Fundamentals of stem cell tissue engineering -- Growth factors and morphogens: signals for tissue engineering -- Extracellular matrix: structure, function, and applications to tissue engineering --Esophagus: a tissue engineering challenge -- Tissue engineered vascular grafts -- Cardiac tissue engineering: matching native architecture and function to develop safe and efficient therapy -- Tissue engineering of heart valves -- Tissue engineering, stem cells and cloning for the regeneration of urologic organs -- Hepatic tissue engineering for adjunct and temporary liver support -- Tissue engineering of renal replacement therapy -- The bioengineering of dental tissues -- Tracheal tissue engineering -- sect. VI. Prostheses and artificial organs. Artificial heart and circulatory assist devices -- Cardiac valve prostheses -- Vascular grafts -- Artificial lungs and blood-gas exchange devices -- Artificial kidney -- Peritoneal dialysis equipment -- Therapeutic apheresis and blood fractionation -- Liver support systems -- Artificial pancreas -- Nerve guidance channels -- Tracheal, laryngeal, and esophageal replacement devices -- Artificial blood -- Artificial skin and dermal equivalents -- sect. VII. Ethics. Beneficence, nonmaleficence, and medical technology -- Ethical isseus related to clinical research.Mechanical forces on cells -- Cell adhesion -- Cell migration -- Inflammatory and immune responses to tissue engineered devices -- Polymeric scaffolds for tissue engineering applications -- Calcium phosphate ceramics for bone tissue engineering -- Biomimetic materials -- Nanocomposite scaffolds for tissue engineering -- Roles of thermodynamic state and molecular mobility in biopreservation -- Drug delivery -- Gene therapy -- Tissue engineering bioreactors -- Animal models for evaluation of tissue-engineered orthopedic implants -- The regulation of engineered tissues: emerging approaches -- Bioengineering of human skin substitutes -- Nerve regeneration: tissue engineering strategies -- Gene therapy and tissue engineering based on muscle-derived stem cells: potential for musculoskeletal tissue regeneration and repair -- Tissue engineering applications - bone -- Cartilage tissue engineering -- Tissue engineering of the tempormandibular joint -- Engineering smoot muscle --Sect. I. Molecular biology. Historical perspective and basics of molecular biology -- Systems and technology involving bacteria -- Recombinant DNA technology using mammalian cells -- sect. II. Transport phenomena and biomimetic systems. Biomimetic systems -- Diffusional processes and engineering design -- Microvascular heat transfer -- Perfusion effects and hydrodynamics -- Animal surrogate systems -- Arterial wall mass transport: the possible role of blood phase resistance in the localization of arterial disease -- Control of the microenvironment -- Interstitial transport in the brain: principles for local drug delivery -- sect. III. Biotechnology. Tools for genome analysis -- Vaccine production -- Protein ngineering -- Metabolic engineering -- Monoclonal antibodies and their engineered fragments --
  • BASICS AND PRINCIPLES: Scaffolds: Micro and Nano Technology -- Biomimetic Materials -- Natural and Synthetic Scaffolds: Adhesion, ECM, Structure, Function, Modification -- Cells: Sources, Growth, Differentiation, Trans-Differentiation -- Embryonic Stem Cells: Sources and Characterization -- Adult Stem Cells: Sources and Characterization -- Isolation and Growth -- Differentiation and Plasticity -- Regulation Mechanisms: Key Signaling Molecules -- Cell and Organ preservation -- Engineering Technologies: Animal Models for Evaluation of Tissue Engineering Constructs -- Biomedical Imaging and Image Processing -- Bioreactors for Tissue Engineering -- Drug delivery -- Gene Therapy -- OROGANS: Liver -- Musculoskeletal Tissues -- Lung -- CNS -- Peripheral Nervous System -- Nephrons -- Biohybrid organs -- Heart and Cardiovascular Engineering -- Eye/Retina -- Respiratory Systems Engineering -- Ear -- Skin -- TISSUE TYPES: Adipose Tissue -- Blood Substitutes -- Angiogenesis and Vascularization -- Bone Tissue -- Brain Tissues -- Cartilage Tissue -- Pancreatic Tissues -- Tendons -- Tissue Engineering in Reproductive Medicine, of Heart Valves, in Oral and Maxillofacial Surgery -- Uro-Gital System/Bladder Tissue.
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