Books by Subject

Biology

  • 2006 Springer
    Willard L. Koukkari and Robert B. Sothern.
    The study of biological rhythms -- General features of rhythms : terminology and characteristics -- Physical and biological time -- Photoperiodism -- Biological oscillators and timers : models and mechanisms -- Tidal and lunar rhythms -- Sexuality and reproduction -- Natural resources and agriculture -- Veterinary medicine -- Society -- Clinical medicine -- Autorhythmometry -- Chronobiometry : analyzing for rhythms.
  • 2003 Wiley
    Paras N. Prasad.
    ch. 1. Introduction -- ch. 2. Fundamentals of Light and Matter -- ch. 3. Basics of Biology -- ch. 4. Fundamentals of Light-Matter Interactions -- ch. 5. Principles of Lasers, Current Laser Technology, and Nonlinear -- ch. 6. Photobiology -- ch. 7. Bioimaging: Principles and Techniques -- ch. 8. Bioimaging: Applications -- ch. 9. Biosensors -- ch. 10. Microarray Technology for Genomics and Proteomics -- ch. 11. Flow Cytometry -- ch. 12. Light-Activated Therapy: Photodynamic Therapy -- ch. 13. Tissue Engineering with Light -- ch. 14. Laser Tweezers and Laser Scissors -- ch. 15. Nanotechnology for Biophotonics: Bionanophotonics -- ch. 16. Biomaterials for Photonics.
  • 2007 Springer
    edited by Marcello Barbieri.
  • 2008 ScienceDirect
    edited by Terence D. Allen.
    Also available: Print – 2008
  • 2006 CRCnetBASE
    edited by Amnon Kohen, Hans-Heinrich Limbach.
  • 2014 CRCnetBASE
    Prakash Singh Bisen, Emeritus Scientist, Defense Research Development Establishment, Defense Research Development Organization, Ministry of Defense, Government of India, Gwalior, India .
    Microscopy -- Microtome -- pH and Buffers -- Spectrophotometer -- Centrifugation -- Radiation Biology -- Chromatography -- Separation Technology -- Histochemical Techniques -- Cytogenetics -- Biomolecules -- Enzymology -- Membranes -- Photosynthesis and Respiration -- Microbiology -- Soil Biology -- Virology -- Immunochemical Methods -- Genetic Engineering -- Molecular Biology -- Biosensors -- Enzyme Immobilization -- Plant Tissue Culture -- Animal Cell Science and Technology -- Bioprocess Engineering -- Environmental Biology -- Bioinformatics
  • 2007 Springer
    M.L. López-Gracia and M.A. Ros.
  • 2008 Springer
    Jesper Hoffmeyer, editor.
    Introduction: Bateson the precursor / Jesper Hoffmeyer -- Angels fear revisited: Gregory Bateson's cybernetic theory of mind applied to religion-science debates / Mary Catherine Bateson -- From thing to relation. On Bateson's bioanthropology / Jesper Hoffmeyer -- What connects the map to the territory? / Tyrone Cashman -- The pattern which connects pleroma to creatura: the autocell bridge from physics to life / Terrence Deacon and Jeremy Sherman -- Bateson's method: double description. What is it? How does it work? What do we learn? / Julie Hui, Tyrone Cashman, and Terrence Deacon -- Gregory Bateson's relevance to current molecular biology / Luis Emilio Bruni -- Process ecology: creatura at large in an open universe / Robert E. Ulanowicz -- Connections in action - bridging implicit and explicit domains / Teresa S.S. Shilhab and Christian Gerlach -- Bateson: biology with meaning / Brian Goodwin -- Gregory Bateson's "uncovery" of ecological aesthetics / Peter Harries-Jones -- Collapsing the wave function of meaning: the epistemological matrix of talk-in-interaction / Donald Favareau -- Re-enchanting evolution: transcending fundamentalisms through a mythopoetic epistemology / Gregory Mengel -- Bateson and Peirce on the pattern that connects and the sacred / Søren Brier -- Bateson, Peirce and the sign of the sacred / Deborah Eicher-Catt.
  • 2006 Springer
    ed. by Lisa Gould and Michelle L. Sauther.
    Lemur origins, history of ecological studies on lemurs, and the ecology of the recently extinct (subfossil) lemurs -- Origin of the Malagasy strepsirhine primates / Ian Tattersall -- Notes on the history of ecological studies of Malagasy lemurs / Alison Jolly and R.W. Sussman -- Ecology and extinction of Madagascar's subfossil lemurs / Laurie R. Godfrey, William L. Jungers, and Gary T. Schwartz -- The evolution of lemur traits, basic and unusual patterns -- Impact of ecology on the teeth of extant lemurs : a review of dental adaptations, function, and life history / Frank P. Cuozzo and Nayuta Yamashita -- Big is beautiful : fat storage and hibernation as a strategy to cope with marked seasonality in the fat-tailed dwarf lemur (Cheirogaleus medius) / Joanna Fietz and K.H. Dausmann -- Polyspecific associations of crowned lemurs and Sanford's lemurs in Madagascar / Benjamin Z. Freed -- Cathemerality in lemurs / Deborah J. Curtis -- Adaptations in the aye-aye : a review / Eleanor J. Sterling and Erin E. McCreless -- Connecting ecology and adaptation : summaries and new studies -- Evolutionary divergence in the brown lemur species complex / Steig E. Johnson -- Ecological diversity and seasonal adaptations of mouse lemurs (Microcebus spp.) / Ute Radespiel -- Social pair-bonding and resource defense in wild red-bellied lemurs (Eulemur rubriventer) / Deborah J. Overdorff and Stacey R. Tecot -- Lemur catta ecology : what we know and what we need to know / Lisa Gould -- Impact of seasonality and reproduction on social structure, ranging patterns, and fission-fusion social organization in red ruffed lemurs / Natalie Vasey -- Ecologically enigmatic lemurs : the sifakas of the eastern forests (Propithecus candidus, P. diadema, P. edwardsi, P. perrieri, P. tattersalli) / Mitchell T. Irwin -- Behavioral and ecological adaptations in two small folivorous lemurs with different social organization : Avahi and Lepilemur / Urs Thalmann -- The feeding ecology and related adaptations of Indri indri / Joyce A. Powzyk and Christopher B. Mowry -- Behavior and ecology of gentle lemurs (genus Hapalemur) / Chia L. Tan -- Lemur adaptations to a changing environment, natural and anthropogenic stress -- Considering climate change effects in lemur ecology and conservation / Patricia C. Wright -- Diet composition, foraging, and feeding behavior in relation to habitat disturbance : implications for the adaptability of ruffed lemurs (Varecia variegata editorium) in Manombo Forest, Madagascar / Jonah Ratsimbazafy -- Overview on the health and disease ecology of wild lemurs : conservation implications / Randall E. Junge and Michelle L. Sauther
  • 2006 Springer
    edited by J. Seckbach.
  • 2007 Springer
    by Ricardo Amils, Cynan Ellis-Evans and Helmut Hinghofer-Szalkay.
  • 2008 Springer
    edited by Eric J. Sargis and Marian Dagosto.
    Earliest evidence of Deltatheroida (Mammalia: Metatheria) from the early Cretaceous of North America / Brian M. Davis, Richard L. Cifelli and Zofia Kielan-Jaworowska -- Evolution of hind limb proportions in kangaroos (Marsupialia: Macropodoidea) / Benjamin P. Kear ... [et al.] -- Changing views in paleontology : the story of a giant (Megatherium, Xenarthra) / Christine Argot -- Evolutionary morphology of the Tenrecoidea (Mammalia) forelimb skeleton / Justine A. Salton and Eric J. Sargis -- Postcranial morphology of Apheliscus and Haplomylus (Condylarthra, Apheliscidae) : evidence for a Paleocene Holarctic origin of Macroscelidea / Tonya A. Penkrot ... [et al.] -- Postcranial skeleton of the Upper Paleocene (Itaboraian) "Condylarthra" (Mammalia) of the Itaboraí Basin, Brazil / Lilian P. Berqvist -- Postcranial osteology of mammals from Salla, Bolivia (late Oligocene) : form, function, and phylogenetic implications / Bruce J. Shockey and Frederico Anaya -- Evolution of the proximal third phalanx in Oligocene-Miocene equids, and the utility of phalangeal indices in phylogeny reconstruction / Jay A. O'Sullivan -- Adaptive zones and the pinniped ankle : a three-dimensional quantitative analysis of carnivoran tarsal evolution / P. David Polly -- The biogeographic origins of Primates and Euprimates : east, west, north, or south of Eden? / Mary T. Silcox -- Evaluating the mitten-gliding hypothesis for Paromomyidae and Micromomyidae (Mammalia, "Plesiadapiformes") using comparative functional morphology of new Paleogene skeletons / Douglas M. Boyer and Jonathan I. Bloch -- Morphological diversity in the skulls of large adapines (Primates, Adapiformes) and its systematic implications / Marc Godinot and Sébastien Couette -- Primate tibiae from the middle Eocene Shanghuang fissure-fillings of eastern China / Marian Dagosto ... [et al.] -- Rooneyia, postorbital closure, and the beginnings of the age of Anthropoidea / Alfred L. Rosenberger, Russell Hogg and Sai Man Wong -- Epitensoric position of the chorda tympani in Anthropoidea : a new synapomorphic character, with remarks on the fissura Glaseri in Primates / Wolfgang Maier -- Evolutionary morphology of the guenon postcranium and its taxonomic implications / Eric J. Sargis, Carl J. Terranova and Daniel L. Gebo -- Analysis of selected hominoid joint surfaces using laser scanning and geometric morphometrics : a preliminary report / William E.H. Harcourt-Smith ... [et al.] -- Comparative primate bone microstructure: records of life history, function, and phylogeny / Johanna Warshaw.
  • [v. 3], 2016
    edited by Alexander Stone Macnow, MD.
    Status: Not Checked OutLane Catalog Record
    The Cell -- Reproduction -- Embryogenesis and Development -- The Nervous System -- The Endocrine System -- The Respiratory System -- The Cardiovascular System -- The Immune System -- The Digestive System -- Homeostasis -- Musculoskeletal System -- Genetics and Evolution.
  • 2006 ScienceDirect
    edited by James Inglese.
    Also available: Print – 2006
  • 2006 CambridgeSoft
    Maryadele J. O'Neil, editor ... [et al.].
    Also available: Print – 2006
  • 2013
    Maryadele J. O'Neil, editor-in-chief ; Patricia E. Heckelman, senior associate editor ; Peter H. Dobbelaar, associate editor ; Kristin J. Roman, assistant editor ; Catherine M. Kenny, senior editorial assistant ; Linda S. Karaffa, technical assistant.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    edited by Harinder P.S. Makkar, Christopher S. McSweeney.
  • 2008 Springer
    Patrice Dion, Chandra Shekhar Nautiyal, editors ; foreword by John D. Rummel.
  • 2008 Springer
    David R. Anderson.
  • 2007 Springer
    Werner Krabs, Stefan Wolfgang Pickl.
  • 2006 Springer
    Jörg Overmann (ed.).
    Syntrophic associations in methanogenic degradation / B. Schink -- Symbiosis between non-related bacteria in phototropic consortia / J. Overmann -- Prokaryotic symbionts of termite gut flagellates : phylogenetic and metabolic implications of a tripartite symbiosis / A. Brune, U. Stingl -- Towards an understanding of the killer trait : Caedibacter endocytobionts in Paramecium / J. Kusch, H.-D. Görtz -- Bacterial ectosymbionts which confer motility : Mixotricha paradoxa from the intestine of the Australian termite Mastotermes darwiniensis / Helmut König ... [et al.] -- Extrusive bacterial ectosymbionts of ciliates / G. Rosati -- Hydrogenosomes and symbiosis / J.H.P. Hackstein, N. Yarlett -- Molecular interactions between Rhizobium and legumes / P. Skorpil, W.J. Broughton -- Molecular mechanisms in the nitrogen-fixing Nostoc-bryophyte symbiosis / J.C. Meeks -- Symbiosis of thioautotrophic bacteria with Riftia pachyptila / F.J. Stewart, C.M. Cavanaugh -- Symbioses of methanotrophs and deep-sea mussels (Mytilidae: Bathymodiolinae) / E.G. DeChaine, C.M. Cavanaugh -- Symbioses between bacteria and gutless marine oligocahetes / N. Dubilier, A. Blazejak, C. Rühland -- Roles of bacterial regulators in the symbiosis between Vibrio fischeri and Euprymna scalopes / K. Geszvain, K. Visick -- Molecular requirements for the colonization of Hirudo medicinalis by Aeromonas veronii / J. Graf.
  • 2011
    Kartik Viswanathan.
    Pancreatic [Beta]-cells secrete insulin to maintain systemic glucose balance. In response to physiological or pathological stresses that increase insulin demand, [Beta]-cells proliferate and enhance insulin secretion to increase insulin output. However, the mechanisms that govern these facultative changes are unclear. In this thesis, I investigate two potential factors in achieving these essential adaptive changes -- hypoxia inducible factor 1 alpha (Hif1a) and prolactin receptor (Prlr). During pregnancy, a common acquire state with increased insulin demand, Hif1a and Hif1a target gene expression, including Vegfa, Glut1, Gck were increased in maternal islets. Using mouse genetics, conditional deletion of Hif1a in [Beta]-cells ([Beta]Hif1a KO) resulted in glucose intolerance in pregnant, but not virgin, mice. Pregnant [Beta]Hif1a KO mice had impaired target gene expression, defective islet insulin secretion, and reduced vascularity. Pregnant mice develop transient hyperlipidemia, and recapitulation of the hyperlipidemia with fat-challenge or lipid treament induced Hif1a, Vegfa, and Pgk1 expression. Similar to pregnant [Beta]Hif1a KO mice, fat-challenged [Beta]Hif1a KO developed hyperglycemia, hypoinsulinemia, and glucose intolerance. All three hyperlipidemic states show ER stress, and treatment of unstressed mouse or human islets with thapsigargin was sufficient to increase Hif1a and downstream targets. To assess the significance of prolactin signaling in [Beta]-cell function and proliferation in adaptive settings, I created a novel conditional Prlr mouse model. In non-pregnant mice with [Beta]-cell-specific deletion of Prlr ([Beta]Prlr KO), glucose homeostasis is normal. However, pregnant [Beta]Prlr KO mice developed significant glucose intolerance. Given the widespread effects of lactogens on [Beta]-cell physiology, I anticipate altered [Beta]-cell proliferation and secretion in [Beta]Prlr KO islets, and current studies are underway to address this hypothesis. Collectively, our work has revealed that in settings of insulin resistance, both Hif1a and Prlr signaling play important roles in regulating the physiological changes required for proper [Beta]-cell function.
  • 2006 Springer
    Wilhelm Foissner, Kuidong Xu.
    vol. 1. Protospathidiidae, Arcuospathidiidae, Apertospathulidae --
  • 2006 Springer
    by Helmut Berger.
  • 2005 Springer
    edited by T. Bartolomaeus & G. Purschke.
  • 2008 Springer
    by John B. Silver.
    Designing a mosquito sampling programme -- Sampling the egg population -- Sampling the larval population -- Sampling the emerging adult population -- Sampling the adult resting population -- Sampling adults by animal bait catches and by animal-baited traps -- Blood-feeding and its epidemiological significance -- Sampling adults with non-attractant traps -- Sampling adults with light-traps -- Sampling adults with carbon dioxide traps -- Sampling adults with visual attraction traps, sound traps, and other miscellaneous attraction traps -- Estimation of the mortalities of the immature stages -- Methods of age-grading adults and estimation of adult survival rates -- Estimating the size of the adult population -- Measuring adult dispersal -- Experimental hut techniques -- Indices of association and species diversity indices.
  • 2007 Springer
    guest editors, James S. Diana, Terry L. Margenau.
  • 2006 CRCnetBASE
    edited by George T.H. Ellison, Alan H. Goodman.
  • 2006 Springer
    Jim O. Vigoreaux.
  • 2015 Springer
    David J. K. Balfour, Marcus R. Munafò, editors.
    The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans. These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic. CTBN Vol 23 The Behavioral Genetics of Nicotine and Tobacco The primary purpose of this book and its companion volume The Neuropharmacology of Nicotine Dependence is to explore the ways in which recent studies on nicotine and its role in tobacco addiction have opened our eyes to the psychopharmacological properties of this unique and fascinating drug. While the present volume considers the molecular and genetic factors which influence behavioral responses to nicotine and how these may impact on the role of nicotine in tobacco dependence, the book The Neuropharmacology of Nicotine Dependence focuses on the complex neural and psychological mechanisms that mediate nicotine dependence in experimental animal models and their relationship to tobacco addiction in humans. These volumes will provide readers with a contemporary overview of current research on nicotine psychopharmacology and its role in tobacco dependence from leaders in this field of research and will hopefully prove valuable to those who are developing their own research programmes in this important topic.
  • 2014 CRCnetBASE
    edited by Carla Mucignat-Caretta, Department of Molecular Medicine, University of Padova, Padova, Italy.
    Chapter 1. Introduction to chemical signaling in vertebrates and invertebrates / Tristram D. Wyatt -- chapter 2. Pheromones and general odor perception in insects / Michel Renou -- chapter 3. First investigation of the semiochemistry of South African dung beetle species / Barend (Ben) Victor Burger -- chapter 4. Pheromone reception in insects : the example of silk moths / Karl-Ernst Kaissling -- chapter 5. Chemical communication in the honey bee society / Laura Bortolotti and Cecilia Costa -- chapter 6. Drosophila pheromones : from reception to perception / Wynand van der Goes van Naters -- chapter 7. How drosophila detect volatile pheromones : signaling, circuits, and behavior / Samarpita Sengupta and Dean P. Smith -- chapter 8. Chemical signaling in amphibians / Sarah K. Woodley -- chapter 9. Vomeronasal organ : a short history of discovery and an account of development and morphology in the mouse / Carlo Zancanaro -- chapter 10. Vomeronasal receptors and signal transduction in the vomeronasal organ of mammals / Simona Francia, Simone Pifferi, Anna Menini, and Roberto Tirindelli -- chapter 11. Central processing of intraspecific chemical signals in mice / Carla Mucignat-Caretta -- chapter 12. Molecular and neural mechanisms of pheromone reception in the rat vomeronasal system and changes in the pheromonal reception by the maturation and sexual experiences / Makoto Kashiwayanagi -- chapter 13. Social cues, adult neurogenesis, and reproductive behavior / Paolo Peretto and Raúl G. Paredes -- chapter 14. Influence of cat odor on reproductive behavior and physiology in the house mouse (mus musculus) / Vera V. Voznessenskaya -- chapter 15. Pheromone of tiger and other big cats / Mousumi Poddar-Sarkar and Ratan Lal Brahmachary -- chapter 16. Cattle pheromones / Govindaraju Archunan, Swamynathan Rajanarayanan, and Kandasamy Karthikeyan -- chapter 17. Pheromones for newborns / Benoist Schaal -- chapter 18. Pheromone processing in relation to sex and sexual orientation / Ivanka Savic -- chapter 19. Human pheromones : do they exist? / Richard L. Doty.
  • 2014 Springer
    Susan L. Andersen, Daniel S. Pine, editors.
    "Brain development, whether typical or atypical, provides the foundation for all behavior and possible psychopathology. This volume takes a comprehensive and translational approach in describing how basic neuronal patterning occurs, organizes into systems, and forms functional and inter-connected networks. The role that hormones and genes play in influencing brain development is also described. The resultant emotional, cognitive, reward, and social systems show how typical development proceeds. The second part of the book describes when the process of development goes awry. Here, a number of childhood disorders are covered. Autism, ADHD, emotional syndromes of bipolar disorder and depression, oppositional defiant disorder and conduct disorder, and sleep and schizophrenia are included in this volume. Written by leading experts in their respective fields, this volume will be a valuable resource to mental health professionals as well as preclinical investigators hoping to gain additional understanding about the neurobiology of the developing brain."--Publisher's website.
  • 2012 ScienceDirect
    edited by Andries Kalsbeek, Martha Merrow, Till Roenneberg, and Russell G. Foster.
    This issue of Progress in Brain Research reviews current knowledge and understanding, provides a starting point for researchers and practitioners entering the field, and builds a platform for further research and discovery. Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.
  • 2006 Springer
    [edited by] J. Fitter, T. Gutberlet, J. Katsaras.
  • 2006 Springer
    edited by Alejandro Estrada ... [et al.].
    Overview of the Mesoamerican primate fauna, primate studies, and conservation concerns / Alejandro Estrada ... [et al.] -- Taxonomy and distributions of Mesoamerican primates / Anthony B. Rylands ... [et al.] -- The biogeographic history of Mesoamerican primates / Susan M. Ford -- Demographic features of Alouatta pigra populations in extensive and fragmented forests / Sarie Van Belle and Alejandro Estrada -- Population structure of black howlers (Alouatta pigra) in southern Belize and responses to Hurricane Iris / Mary S.M. Pavelka and Colin A. Chapman -- The effects of forest fragment age, isolation, size, habitat type, and water availability on monkey density in a tropical dry forest / Holly Noelle DeGama-Blanchet and Linda Marie Fedigan -- Forest fragmentation and its effects on the feeding ecology of black howlers (Alouatta pigra) from the Calakmul area in Mexico / Andrómeda Rivera and Sophie Calmé -- Intestinal parasitic infections in Alouatta pigra in tropical rainforest in Lacandona, Chiapas, Mexico : implications for behavioral ecology and conservation / Kathryn E. Stoner and Ana González Di Pierro -- Average body weight for mantled howling monkeys (Alouatta palliata) : an assessment of average values and variability / Kenneth E. Glander -- An exploratory analysis of developmental plasticity in Costa Rican mantled howler monkeys (Alouatta palliata palliata) / Clara B. Jones -- Travel patterns and spatial mapping in Nicaraguan mantled howler monkeys (Alouatta palliata) / Paul A. Garber and Petra E. Jelinek -- Use of landmark cues to locate feeding sites in wild capuchin monkeys (Cebus capucinus) : an experimental field study / Paul A. Garber and Ellen Brown -- Leap, bridge, or ride? Ontogenetic influences on positional behavior in Cebus and Alouatta / Michelle F. Bezanson -- Food choice by juvenile capuchin monkeys (Cebus capucinus) in a tropical dry forest / Katherine C. MacKinnon -- Why be alpha male? Dominance and reproductive success in wild white-faced capuchins (Cebus capucinus) / Katharine M. Jack and Linda M. Fedigan -- Post-conceptive mating in white-faced capuchins, Cebus capucinus : hormonal and sociosexual patterns of cycling, noncycling, and pregnant females / Sarah D. Carnegie, Linda M. Fedigan and Toni E. Ziegler -- Growth of a reintroduced spider monkey (Ateles geoffroyi) population on Barro Colorado Island, Panama / Katharine Milton and Mariah E. Hopkins -- Primates in agroecosystems : conservation value of some agricultural practices in Mesoamerican landscapes / Alejandro Estrada ... [et al.] -- Primate populations in the protected forests of Maya archaeological sites in southern Mexico and Guatemala / Alejandro Estrada ... [et al.] -- Mapping primate populations in the Yucatan Peninsula, Mexico : a first assessment / Juan Carlos Serio-Silva, Víctor Rico-Gray and Gabriel Ramos-Fernández -- A metapopulation approach to conserving the howler monkey in a highly fragmented landscape in Los Tuxtlas, Mexico / Salvador Mandujano ... [et al.] -- Quantifying fragmentation of black howler (Alouatta pigra) habitat after Hurricane Iris (2001), southern Belize / Shelley M. Alexander, Mary S.M. Pavelka and Nicola H. Bywater -- New perspectives in the study of Mesoamerican primates : concluding comments and conservation priorities / Paul A. Garber, Alejandro Estrada and Mary S.M. Pavelka.
  • 2008 CRCnetBASE
    edited by Quentin D. Wheeler.
    Introductory : toward the new taxonomy / Quentin D. Wheeler -- Networks and their role in e-taxonomy / Malcolm J. Scoble -- Taxonomy as a team sport / Sandra Knapp -- Planetary biodiversity inventories as models for the new taxonomy / Lawrence M. Page -- On the use of taxonomic concepts in support of biodiversity research and taxonomy / Nico M. Franz, Robert K. Peet and Alan S. Weakley -- International infrastructure for enabling the new taxonomy : the role of the Global Biodiversity Information Facility (GBIF) / Larry Speers and James L. Edwards -- DNA sequence in taxonomy : opportunities and challenges / Rudolf Meier -- Animal names for all : ICZN, ZooBank and the new taxonomy / Andrew Polaszek, Richard Pyle and Doug Yanega -- Understanding morphology in systematic contezxt : three-dimensional specimen ordination and recognition / Norman MacLeod -- Taxonomic shock and awe / Quentin D. Wheeler.
  • 2013 ScienceDirect
    edited by Lisa Plitnick, Danuta Herzyk.
    Machine generated contents note: I.Development of Biophar-Maceuticals Defined as Novel Biologics -- 1.Overview of Biopharmaceuticals and Comparison with Small-molecule Drug Development / Thomas R. Gelzleichter -- Introduction -- History and Evolution of Biopharmaceuticals -- Development of Diverse Biopharmaceutical Modalities -- Comparison of Small-Molecule Drugs to Biopharmaceuticals -- Summary -- References -- 2.Regulatory Guidelines and their Application in the Nonclinical Evaluation of Biological Medicines / Maggie Dempster -- Introduction -- Species Selection -- Study Design Considerations for Repeat-Dose Studies -- Immunogenicity -- Reproductive and Developmental Toxicity -- Genotoxicity and Carcinogenicity -- Special Considerations for Anticancer Drugs -- First-in-Human (Fih) Clinical Trial -- Summary -- References -- 3.Early De-risking Strategy for Novel Biotherapeutics / Beth Hinkle -- Introduction -- Establishing A Safety Profile for Biotherapeutics -- General Safety Considerations Related to Biotherapeutics -- Progress in Evaluation of Immunotoxicity -- Can We Better Address Potential Off-Target Toxicity? -- Summary -- References -- 4.Novel Biopharmaceuticals: Pharmacokinetics, Pharmacodynamics, and Bioanalytics / Wolfgang Seghezzi -- Introduction -- Absorption, Distribution and Elimination of Biopharmaceuticals -- Disposition of Modified Molecules -- "Metabolism" and Biodistribution for Biopharmaceuticals -- Immunogenicity and impacts on PK and biodistribution -- Pharmacokinetics and Pharmacodynamics -- Preclinical to Clinical Translation -- Bioanalytics -- Drug Assays -- Biomarkers: Target Engagement Assays -- Immunogenicity Assessment: ADA Assays -- Summary -- References -- II.Development of Biosimilars -- 5.Overview of Biosimilar Therapeutics / Danuta J. Herzyk -- Introduction -- The Concept of Biosimilars -- General Considerations for Development of Biosimilars -- Biosimilar Candidates Based on Modality and Therapeutic Class -- Summary -- References -- 6.Regulatory Standards for the Approval of Biosimilar Products: A Global Review / Barbara Mounho-Zamora -- Introduction -- European Union -- Pioneer for the First Regulatory Pathway for Biosimilar Products -- The World Health Organization Guidance on Biosimilars -- Regulatory Pathway for Biosimilar Products in the United States -- Biosimilar Pathways in Other Regions -- Summary -- References -- 7.Early Characterization of Biosimilar Therapeutics / Thomas R. Gelzleichter -- Introduction -- Recombinant Insulins -- Recombinant Human Growth Hormone -- Recombinant Erythropoietins -- Recombinant Granulocyte Colony-Stimulating Factor -- Recombinant Interferons -- Low Molecular Weight Heparins -- Monoclonal Antibodies -- Other Classes -- Summary -- References -- III.Vaccines -- 8.Introduction to Vaccines and Adjuvants / Deborah L. Novicki -- Introduction -- The History of Vaccines -- The Impact of Vaccines on Human Health -- Advancements in Vaccines Technologies -- Advancements in Adjuvant Technologies -- Approved Infectious Disease Vaccines and Diseases for Which Preventive Vaccines are Still Needed -- Therapeutic Vaccines -- Product Complexity From a Quality Perspective -- Nonclinical Testing -- Clinical Testing -- Vaccine Development Using the Animal Rule -- The Anti-Vaccines Movement and Misperceptions About Vaccines and Their Safety -- Summary -- References -- 9.Global Regulatory Guidelines for Vaccines / Lisa M. Plitnick -- Introduction -- Toxicity Assessment -- Additional Toxicity Assessments -- Special Considerations -- Formulation/Delivery Devices -- Alternate Routes of Administration -- Special Considerations for Particular Types of Vaccines -- Summary -- References -- 10.Special Considerations for the Nonclinical Safety Assessment of Vaccines / Jayanthi J. Wolf -- Introduction -- De-risking Strategies for Vaccines -- Pharmacokinetics and Pharmacodynamics Assessments -- Differences in the Nonclinical Safety Assessment of Vaccines and Biopharmaceutical Drugs -- Summary -- References -- IV.Specialty Biologics and Indications -- 11.Turning the Corner with Viral-based Gene Therapy -- Development of the Rogue Biopharmaceutical / Timothy K. Maclachlan -- Introduction -- A History and Primer of Gene Therapy -- The Process of Getting Genes into Cells -- Health Authority Regulation of Gene Therapy Products -- Nonclinical Safety Studies and Regulatory Guidance -- Summary -- References -- 12.Blood Products / Vikram Arora -- Introduction -- Plasma-Derived Blood Products -- Blood Products Derived from Recombinant Technologies -- Summary -- References -- 13.Biological Therapies for Cancer / Gautham K. Rao -- Introduction -- Global Regulatory Guidances -- General Principles of Toxicology Assessments -- Nonclinical Studies and Principles of Study Design -- Specialty Toxicology Assessments -- Pharmacokinetics, Immunogenicity, and Pharmacodynamics -- Nonclinical Development of Marketed Biologies -- Recombinant Analogs of Endogeneous Human Proteins (Interferons, Cytokines, Enzymes) -- Summary -- References -- 14.Nonclinical Development of Multi-targeting Biopharmaceuticals / Anu V. Connor -- Introduction -- Scientific Rationale for Multi-Targeting Biopharmaceuticals (MTBs) -- Evolution of Technology Platforms -- General Challenges and Considerations -- Summary of Challenges -- T Cell-Dependent Bispecific Antibody (TDB) Biotherapeutics -- Dual-Targeting Antibodies -- Summary -- References -- 15.Considerations in the Development of Pluripotent Stem Cell-based Therapies / Joy A. Cavagnaro -- Introduction -- Early Decisions -- Nonclinical Development -- Translating Preclinical Data to Clinical Application -- Global Regulatory Guidance -- Summary -- References.
  • 2007 Springer
    Petra Marschner and Zdenko Rengel (eds.)
  • 2008 Springer
    by Andrii Rozhok.
  • 2008 Springer
    Giuseppe Valacchi, editor ; Paul A. Davis, co-editor.
  • 2007 ScienceDirect
    edited by Helmut Sies and Bernard Brüne.
    Also available: Print – 2007
  • 2006 Springer
    edited by Giuseppe Cicco... [et al.].
    Also available: Print – 2006
  • 2008 Springer
    edited by Lars Olof Björn.
  • 2013 Springer
    John A. Fuerst, editor.
    History, classification and cultivation of the planctomycetes / Cheryl Jenkins and James T. Staley -- Cell compartmentalization and endocytosis in planctomycetes: structure and function in complex bacteria / John A. Fuerst, Richard I. Webb, and Evgeny Sagulenko -- Structural aspects of MC proteins of PVC superphylum members / Damien P. Devos -- Cell biology of anaerobic ammonium-oxidizing bacteria: unique prokaryotes with an energy-conserving intracellular compartment / Sarah Neumann, Muriel C.F. van Teeseling and Laura van Niftrik -- Acidophilic planctomycetes: expanding the horizons of new planctomycete diversity / Svetlana N. Dedysh and Irina S. Kulichevskaya -- Toward the development of genetic tools for Planctomycetes / Mareike Jogler and Christian Jogler -- Genomics and bioinformatics of the PVC superphylum / Olga K. Kamneva, Daniel H. Haft, Stormy J. Knight, Davide A. Liberles, and Naomi L. Ward -- Distribution and evolution of C1 transfer enzymes and evolution of the planctomycetes / Ludmila Chistoserdova -- Unusual members of the PVC superphylum: the methanotrophic Verrucomicrobia genus "Methylacidiphilum" / Christine E. Sharp, Huub J.M. Op den Camp, Ivica Tamas, and Peter F. Dunfield -- Phyla related to Planctomycetes: members of phylum Chlamydiae and their implications for Planctomycetes cell biology / Claire Bertelli and Gilbert Greub -- Planctomycetes: their evolutionary implications for models for origins of eukaryotes and the eukaryote nucleus and endomembranes / John A. Fuerst and Evgeny Sagulenko -- Final word: the future of planctomycetology and related studies / John A. Fuerst -- Index.
  • 2008 Springer
    Berryman, A. A.; Berryman, A. A.; Kindlmann, Pavel.
  • 2007 Springer
    by Ragan M. Callaway.
  • 2002 ebrary
    R. Barker Bausell, Yu-Fang Li.
    The conceptual underpinnings of statistical power -- Strategies for increasing statistical power -- General guidelines for conducting a power analysis -- The t-test for independent samples -- The paired t-test -- One-way between subjects analysis of variance -- One-way between subjects analysis of covariance -- One-way repeated measures analysis of variance -- Interaction effects for factorial analysis of variance -- Power analysis for more complex designs -- Other power analytic issues and resources for addressing them.
  • 2007 Springer
    Uta B. Schambra
  • 2006 Springer
    [edited by] Shawn M. Lehman, John G. Fleagle.
    Biogeography and primates : a review / Shawn M. Lehman, John G. Fleagle -- Nested distribution patterns and the historical biogeography of the primates of Guyana / S.M. Lehman -- Genetic evidence on the historical biogeography of Central American howler monkeys / Julie A. Ellsworth, Guy A. Hoelzer -- Ecological biogeography of primates in Guyana / S.M. Lehman ... [et al.] -- Contrasting phylogeographic histories of chimpanzees in Nigeria and Cameroon : a multi-locus genetic analysis / M. Katherine Gonder, Todd R. Disotell -- Geographic variation in Savanna baboon (Papio) ecology and its taxonomic and evolutionary implications / Jason M. Kamilar -- Biogeography and evolution of the Cercocebus-Mandrillus clade : evidence from the face / W. Scott McGraw, John G. Fleagle -- Mouse lemur phylogeography revises a model of ecogeographic constraint in Madagascar / Anne D. Yoder, Kellie L. Heckman -- Abiotic and biotic factors as predictors of species richness on Madagascar / Nancy J. Stevens, Patrick M. O'Connor -- The geography of mammals and rivers in mainland Southeast Asia / Erik Meijaard, Colin Peter Groves -- Primate biogeography and ecology on the Sunda Shelf islands : a paleontological and zooarchaeological perspective / Terry Harrison, John Krigbaum, Jessica Manser -- The biogeography of primate evolution : the role of plate tectonics, climate and chance / John G. Fleagle, Christopher C. Gilbert -- Biogeographic origins of primate higher taxa / Christopher P. Heesy, Nancy J. Stevens, Karen E. Samonds -- Mammalian biogeography and anthropoid origins / K. Christopher Beard -- Continental paleobiogeography as phylogenetic evidence / James B. Rossie, Erik R. Seiffert.
  • 2006 Springer
    edited by Nicholas E. Newton-Fisher ... [et al.].
    Taxonomy and biogeography of the primates of western Uganda / Colin Groves -- Factors influencing variation in the population densities of Colobus guereza within selectively logged forest at the Budongo Reserve : the importance of lianas during a subsistence diet / Graham Anthony Preece -- How does the golden monkey of the Virungas cope in a fruit-scarce environment? / Dennis Twinomugish ... [et al.] -- The diet of olive baboons (Papio anubis) in Budongo Forest Reserve, Uganda / Adam Alberts Okecha and Nicholas E. Newton-Fisher -- Aspects of diet, foraging, and seed predation in Ugandan forest baboons / James D. Paterson -- The interaction of hormones with ecological factors in male Budongo Forest chimpanzees / Sally B. Seraphin, Patricia L. Whitten, and Vernon Reynolds -- The role of diet in self-medication among chimpanzees in the Sonso and Kanyawara communities, Uganda / Paula Pebsworth, Sabrina Krief, and Michael A. Huffman -- Geophagy in chimpanzees (Pan troglodytes schweinfurthii) of the Budongo Forest Reserve, Uganda : a multidisciplinary study / Mnason Tweheyo ... [et al.] -- Nutritional aspects of the diet of wild gorillas : how do Bwindi gorillas compare? / Jessica M. Rothman ... [et al.] -- The parasites of the gorillas in Bwindi Impenetrable National Park, Uganda / Jessica M. Rothman ... [et al.] -- Preliminary GIS analysis of range use by sympatric mountain gorillas and chimpanzees in Bwindi Impenetrable National Park, Uganda / J. Bosco Nkurunungi and Craig B. Stanford -- Comparison of sex differences in gregariousness in fission-fusion species : reducing bias by standardizing for party size / Melissa Emery Thompson and Richard W. Wrangham -- Urinary estrone conjugates and reproductive parameters in Kibale (Kanyawara) and Budongo (Sonso) chimpanzees / Melissa Emery Thompson, Richard W. Wrangham, and Vernon Reynolds -- Frequent copulations by females and high promiscuity in chimpanzees in the Kalinzu Forest, Uganda / Chie Hashimoto and Takeshi Furuichi -- Effects of injury on the locomotion of free-living chimpanzees in the Budongo Forest Reserve, Uganda / Julie Munn -- Effect of snare injuries on the fig-feeding behavior of chimpanzees of the Budongo Forest, Uganda : behavioral adaptations and long-term implications / Emma J. Stokes and Richard W. Byrne -- Deciphering junglespeak : an update on chimpanzee vocalizations, referential communication, and their relationship to language / Hugh Notman -- Instrumental leaf use by chimpanzees of the Budongo Forest (Sonso community) / Duane Quiatt -- A survey of prosimians in the national parks and forest reserves of Uganda / Lesley Ambrose -- The diets, preferences, and overlap of the primate community in the Budongo Forest Reserve, Uganda : effects of logging on primate diets / Andrew J. Plumptre -- Behavioral patterns of colobus in logged and unlogged forests : the conservation value of harvested forests / Colin A. Chapman, Michael D. Wasserman, and Thomas R. Gillespie -- Threats to, and protection of, the chimpanzees of the Budongo Forest Reserve / Vernon Reynolds -- Gorillas living on the edge : literally and figuratively / Michele L. Goldsmith, Joel Glick, and Evarist Ngabirano -- Local ecological perceptions of chimpanzees and forest resources : a case study near Budongo Forest, Uganda / Cristy Watkins.
  • v. 2-15, 1995-2004. ScienceDirect
  • 2007 Springer
    edited by Almaz Aldashev, Robert Naeije.
  • 2014 Springer
    Jaroslava Halper, editor.
    This volume is a reference handbook focusing on diseases like Marfan syndrome, Ehlers-Danlos syndrome, Loeys-Dietz syndrome and other heritable soft connective tissue diseases. The book presents detailed information for both basic scientists and for clinicians seeing patients. It is also a stepping stone for new investigations and studies that goes beyond the facts about the composition and biochemistry of the connective tissue and extracellular matrix, as the authors connect individual components to specific aspects of various soft tissue disorders and to the actual or potential treatment of them. Progress in Heritable Soft Connective Tissue Diseases features very prominent physicians and scientists as contributors who bring their most recent discoveries to the benefit of readers. Their expertise will help clinicians with proper diagnosis of sometimes elusive and uncommon heritable diseases of soft connective tissues. This book also offers an update on the pathophysiology of these diseases, including an emphasis on unifying aspects such as connections between embryonic development of the different types of connective tissues and systems, and the role of TGF-beta in development and physiology of soft tissues. This new set of data explains, at least in part, why many of these disorders are interconnected, though the primary pathophysiological events, such as gene mutations, may be different for each disorder.
    Also available: Print – 2014
  • 2005 Springer
    J. Morser, S.I. Nishikawa, editors.
    Melanocyte system for studying stem cell niche -- Establishment and maniupulation of monkey and human embryonic stem cell lines for biomedical research -- Human embryonic stem cell derivation -- In search of the elusive epidermal stem cell -- Corneal cells for regeneration -- Polycomb gene product Bmi-l -- Directed differentiation of neural and sensory tissues from embryonic stem cells in vitro -- Stem cell biology for vascular regeneration.
  • 2002 Wiley
    edited by Marc H.V. Van Regenmortel, David L. Hull.
    ch. 1. Introduction / David L. Hull and Marc H. V. Van Regenmortel, p. 1-13 -- ch. 2. Emergent Properties of Biological Molecules and Cells / Robert J. P. Williams, p. 15-34 -- ch. 3. From Nineteenth Century Ideas on Reduction in Physiology to Non-Reductive Explanations in Twentieth-Century Biochemistry / Claude Debru, p. 35-46 -- ch. 4. Pitfalls of Reductionism in Immunology / Marc H. V. Van Regenmortel, p. 47-66 -- ch. 5. Reductionism in Medicine: Social Aspects of Health / Elisabeth A. Lloyd, p. 67-82 -- ch. 6. 'Who's Afraid of Reductionism?' 'I Am!' / Stanley Shostak, p. 83-111 -- Round Table Discussion 1/ chair Alex Rosenberg, p. 113-123 -- ch. 7. Reductionism in an Historical Science / Alex Rosenberg, p. 125-160 -- ch. 8. Varieties of Reductionism: Derivation and Gene Selection / David L. Hull, p. 161-177 -- ch. 9. The Gene: Between Holism and Generalism / Michel Morange, p. 179-189 -- ch. 10. Genes versus Molecules: How To, and How Not To, Be a Reductionist / Sahotra Sarkar, p. 191-209 -- ch. 11. Limits of Reproduction: A Reductionistic Research Strategy in Evolutionary Biology / James Griesemer, p. 211-231 -- ch. 12. Evolutionary Psychology: A Case Study in the Poverty of Genetic Determinism / John Dupré, p. 233-251 -- Round Table Discussion 2 / chair Marc Van Regenmortel, p. 253-260 -- ch. 13. The Ethical Imperative of Holism in Medicine / Alfred I. Tauber, p. 261-278 -- ch. 14. Levels of Explanation in Human Behaviour: The Poverty of Evolutionary Psychology / Steven P. R. Rose, p. 279-304 -- ch. 15. Reductionism and Social Policy / Dorothy Nelkin, p. 305-321 -- ch. 16. Reductionism, Complexity and Molecular Medicine: Genetic Chips and the 'Globalization' of the Genome / Kenneth F. Schaffner, p. 323-351 -- Round Table Discussion 3 / chair Kenneth F. Schaffner, p. 353-363.
  • 2012 Springer
    J. Robin Harris, editor.
    Introduction and technical survey: Protein aggregation and fibrillogenesis -- Fibril formation by short synthetic peptides -- In vitrooligomerization and fibrillogenesis of amyloid-beta peptides -- Tau fibrillogenesis -- Prion protein aggregation and fibrillogenesisin vitro -- Alpha-synuclein aggregation and modulating factors -- Pathological self-aggregation of [beta](2)-microglobulin: A challenge for protein biophysics -- Islet amyloid polypeptide: Aggregation and fibrillogenesisin vitroand its inhibition -- Mechanisms of transthyretin aggregation and toxicity -- Fibrillogenesis of huntingtin and other glutamine containing proteins -- Aggregation and fibrillogenesis of proteins not associated with disease: a few case studies -- Experimental inhibition of peptide fibrillogenesis by synthetic peptides, carbohydrates and drugs -- Experimental inhibition of fibrillogenesis and neurotoxicity by amyloid-beta (abeta) and other disease-related peptides/proteins by plant extracts and herbal compounds -- Alzheimer's disease -- Modeling the polyglutamine aggregation pathway in Huntington's disease: from basic studies to clinical applications -- Parkinson's disease -- Human prion diseases: From kuru to variant Creutzfeldt-Jakob disease -- Animal prion diseases -- [beta](2)-Microglobulin amyloidosis -- Systemic AA amyloidosis -- Familial amyloidotic polyneuropathy and transthyretin -- The challenge of systemic immunoglobulin light-chain amyloidosis (AL).
  • 2005 Springer
    edited by S. Mohan Jain and Pramod K. Gupta.
  • 2008 Springer
    Rosa Margesin ... [et. al.], editors.
  • 2013 CRCnetBASE
    Jerome Goddard.
    "Increasing problems of emerging and re-emerging infectious diseases, brought about, at least in part, by vectors fueled by increased worldwide travel and commerce, make this a highly timely book for anyone in the public practice of medical and veterinary entomology, including entomologists, public health officials, and pest control technicians and managers. Employing a reader-friendly style with bulleted texts, scenarios, and case history boxes, it targets the major vectors and pests of medical and public health importance, addresses regulatory and academic medical entomology, and discusses disease vector control with worldwide application"--Provided by publisher.
  • 2012
    Stefanie Duttler.
    One of the most critical times in the life of a protein is during its biogenesis at the ribosome. A nascent polypeptide cannot achieve its final fold while still bound to the ribosome, and is at risk of being accessed by the cellular quality control machinery. However, the extent to which cotranslational ubiquitination and degradation occur remains under debate. Conflicting reports exist, ranging from 40% of nascent chains being subject to cotranslational degradation to claims that nascent polypeptides are, on the contrary, protected from degradation. Here, we developed a direct and quantitative method to determine the extent of cotranslational ubiquitination using ribosome isolation coupled to ubiquitin-affinity purification. We find that cotranslational ubiquitination occurs at low levels, and that at least a fraction of ubiquitinated nascent chains is targeted to the proteasome for degradation. We determined which proteins are susceptible to cotranslational ubiquitination and find that intrinsic sequence features determine the cotranslational ubiquitination of a specific subset of proteins. These proteins are more aggregation-prone, highly expressed and longer than 400 amino acids. Short proteins seem to be protected from cotranslational ubiquitination. One such mechanism could be the cotranslational formation of folded structures, which lead us to disrupt cotranslational folding by deleting chaperones or through drugs such as azetidine-2-carboxylic acid (AZC). Both lead to an increase of cotranslational ubiquitination as observed by pulse-labeling as well as microarray analysis. Ribosome-associated chaperones and cotranslational folding seem to have evolved to prevent a high degree of nascent chain degradation/ubiquitination. Similarly to ribosome-associated chaperones, the ubiquitin-proteasome-system may also be able to access nascent protein chains, but rather target them for degradation. We therefore determined which parts of the UPS mediate cotranslational ubiquitination. A clear E2-E3 relationship could however not be established, possibly due to redundancy in the cellular ubiquitin ligase network. Finally, we find that disruption of mRNA quality control components also leads to enhanced ubiquitination of nascent chains, suggesting that cotranslational quality control serves to avoid the production of erroneous proteins and protect the cell from resulting toxicity.
  • 2014 Springer Protocols
    edited by Adriana Fontes, Beate Saegesser Santos.
  • 2006 Springer Protocols
    edited by Charles Z. Hotz, Marcel Bruchez.
    Immunofluorescent labeling of proteins in cultured cells with quantum dot secondary antibody conjugates / Richard L. Ornberg and Hongjian Liu -- Immunohistochemical detection with quantum dots / Rizwan S. Akhtar ... [et al.] -- Quantum dots for multicolor clinical pathology and multispectral imaging / Johbu Itoh and Robert Yoshiyuki Osamura -- Light and electron microscopic localization of multiple proteins using quantum dots / Thomas J. Deerinck ... [et al.] -- Human metaphase chromosome fluorescence in situ hybridization using quantum dot conjugates / Joan H.M. Knoll -- Biotin-ligand complexes with streptavidin quantum dots for in vivo cell-labeling of membrane receptors / Diane S. Lidke ... [et al.] -- Single quantum dot tracking of membrane receptors / Cødric Bouzigues ... [et al.] -- Optical monitoring of single cells using quantum dots / Jyoti K. Jaiswal and Sanford M. Simon -- Peptide-mediated intracellular delivery of quantum dots / B. Christoffer Lagerholm -- High-content analysis in multiple cell lines using quantum dots / Paul G. Wylie -- Measuring cell motility using quantum dot probes / Weiwei Gu ... [et al.] -- Quantum dots for in vivo molecular and cellular imaging / Xiaohu Gao, Leland W.K. Chung, and Shuming Nie -- Sentinel lymph node mapping with type II quantum dots / John V. Frangioni ... [et al.] -- Macrophage-mediated colocalization of quantum dots in experimental glioma / Osman Muhammad, Alexandra Popescu, and Steven A. Toms -- Applications of quantum dots to multicolor flow cytometry / Pratip K. Chattopadhyay and Mario Roederer -- Quantum dots in flow cytometry / Barnaby Abrams and Tim Dubrovsky -- Luminescent biocompatible quantum dots: a tool for immunosorbent assay design / Ellen R. Goldman ... [et al.] -- Fluorescence-based analysis of cellular protein lysate arrays using quantum dots / David H. Geho ... [et al.] -- Application of quantum dots to multicolor microarray experiments: four-color genotyping / George Karlin-Neumann ... [et al.].
  • 2009 Springer
    Samantha J. Richardson, Vivian Cody [editors].
  • 2007 CRCnetBASE
    edited by Trevor R. Hodkinson, John A.N. Parnell.
    section A. Introduction and general context -- section B. Reconstructing and using the tree of life -- section C. Taxonomy and systematics of species rich groups (case studies).
  • 2011
    Manuel Eduardo Lopez, Jr.
    Niemann-Pick disease type C (NPC) is a rare metabolic lysosomal storage disorder (LSD) marked by accumulation of large quantities of cholesterol, lipids and other metabolites in cells. Though the disorder has been extensively explored using various genetic animal models, an understanding of the molecular and cellular pathology of the disease remains limited. A cell-type-specific and regulable rescue mouse model of NPC disease was engineered in order to identify the therapeutically relevant cell type and ascertain the effect of inflammation on disease progression. With the current information presented in this dissertation, a probable road map of NPC disease pathology has been drawn. The road map for NPC may also be applicable to, or act as a template for, other lysosomal storage diseases and neurodegenerative disorders with similar pathologies.
  • 2010
    Daniel Richard Calnan.
    The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme longevity in humans and to regulate the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. The activity of FoxO3 is controlled by a variety of post-translational modifications that have been proposed to form a 'code' affecting FoxO3 subcellular localization, DNA binding ability, protein-protein interactions and protein stability. Lysine methylation is a key post-translational modification on histones that regulate chromatin accessibility and is a key part of the 'histone code'. However, whether lysine methylation plays a role in modulating FoxO3 activity has never been examined. I found that the methyltransferase Set9 directly methylates FoxO3 in vitro and in cells. Using a combination of tandem mass spectrometry and methyl-specific antibodies, I find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1. Methylation of FoxO3 by Set9 decreases FoxO3 protein stability, while slightly increasing FoxO3 transcriptional activity. The modulation of FoxO3 stability and activity by methylation may be critical for fine-tuning cellular responses to stress stimuli, which may in turn affect FoxO3's ability to promote tumor suppression and longevity. Post-translational modifications control many aspects of FoxO3 activity, including protein stability, subcellular localization and binding partner association. To analyze whether FoxO3 functions primarily alone, or in a complex with other factors, I used size exclusion chromatography to assess the size of the potential FoxO3 protein complexes in cellular extracts. I found that FoxO3 is present in fractions with a relative molecular weight larger ranging from 250 to 700 kDa. Interestingly, the cytoplasmic fraction of FoxO3 appears to be in a larger complex than the nuclear fraction, suggesting that FoxO3 is present in more than one protein complex in cells. To identify novel binding partners of FoxO3 that could be present in these large molecular-weight protein complexes, I conducted a tandem affinity purification (TAP) of dual tagged FoxO3 in HeLa S3 cells followed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) of the elution from the immunoprecipitation. I identified over 1,000 potential FoxO3 binding partners that were not present in the control immunoprecipitation. These candidate binding partners included protein kinases (e.g. mTOR, MAPKs), other tumor suppressors (e.g. p65, p130) and oncogenes (e.g.Myb), as well as proteins that contain a methyl lysine (e.g. WDR17, PHF3) and acetyl lysine (e.g. BAZ2B, BRD1) binding domains. Taken together, these results suggest that FoxO3 functions in large protein complexes that could affect FoxO3 activity. The formation of FoxO3-containing complexes could be triggered by FoxO3 post-translational modifications. By increasing our understanding of the regulation of FoxO3, as well identifying possible interacting proteins, we further our knowledge of the pathways important for both longevity and age related diseases, including cancer.
  • 2006 Springer
    edited by Larissa Swedell and Steven R. Leigh.
    Perspectives on reproduction and life history in baboons / Larissa Swedell & Steven R. Leigh -- Infant mortality, paternity certainty, and female reproductive strategies in hamadryas baboons / Larissa Swedell & Julian Saunders -- Female behavioral strategies of hybrid baboons in the Awash National Park, Ethiopia / Jacinta C. Beehner & Thore J. Bergman -- Hybrid baboons and the origins of the hamadryas male reproductive strategy / Thore J. Bergman -- The social and ecological flexibility of Guinea baboons : implications for Guinea baboon social organization and male strategies / Anh Galat-Luong, Gérard Galat & Suzanne Hagell -- Social organization, reproductive systems, and mediation of baboon endogenous virus (BaEV) copy number in gelada, hamadryas, and other Papio baboons / Monica Uddin, Jane E. Phillips-Conroy & Clifford J. Jolly -- Reproduction, mortality, and female reproductive success in chacma baboons of the Okavango Delta, Botswana / Dorothy L. Cheney ... [et al.] -- Maternal characteristics and offspring growth in chacma baboons : a life-history perspective / Sara E. Johnson -- Whose life is it anyway? Maternal investment, developmental trajectories, and life history strategies in baboons / Louise Barrett, S. Peter Henzi & John E. Lycett -- Ontogeny, life history, and maternal investment in baboons / Steven R. Leigh & Robin M. Bernstein -- Testicular size, developmental trajectories, and male life history strategies in four baboon taxa / Clifford J. Jolly & Jane E. Phillips-Conroy -- The evolutionary past and the research future : environmental variation and life history flexibility in a primate lineage / Susan C. Alberts & Jeanne Altmann.
  • 2006 Springer
    edited by Alison Jolly ... [et al.].
    The distribution and biogeography of the ringtailed lemur (Lemur catta) in Madagascar / Steven M. Goodman, Soava V. Rakotoarisoa and Lucienne Wilmé -- A preliminary estimate of Lemur catta population density using satellite imagery / Robert W. Sussman ... [et al.] -- Berenty Reserve : a research site in southern Madagascar / Alison Jolly ... [et al.] -- Beza Mahafaly Special Reserve : a research site in southwestern Madagascar / Robert W. Sussman and Joelisoa Ratsirarson -- Plant species fed on by Lemur catta in gallery forests of the southern domain of Madagascar / Bruno Simmen ... [et al.] -- Tamarind recruitment and long-term stability in the gallery forest at Berenty, Madagascar / Kathryn Blumenfeld-Jones ... [et al.] -- Home ranges of ringtailed lemur troops and the density of large trees at Berenty Reserve, Madagascar / Naoki Koyama ... [et al.] -- The influence of tamarind tree quality and quantity on Lemur catta behavior / Anne S. Mertl-Millhollen ... [et al.] -- Feeding competition between introduced Eulemur fulvus and native Lemur catta during the birth season at Berenty Reserve, southern Madagascar / Susan Pinkus, James N.M. Smith and Alison Jolly -- Tradition and novelty : Lemur catta feeding strategy on introduced tree species at Berenty Reserve / Takayo Soma -- Diet quality and taste perception of plant secondary metabolites by Lemur catta / B. Simmen ... [et al.] -- Territory as bet-hedging : Lemur catta in a rich forest and an erratic climate / Alison Jolly ... [et al.] -- Resource defense in Lemur catta : the importance of group size / R. Ethan Pride ... [et al.] -- Social changes in a wild population of ringtailed lemurs (Lemur catta) at Berenty, Madagascar / Shinichiro Ichino and Naoki Koyama -- Obsession with agonistic power / Michael. E. Pereira -- Male and female ringtailed lemurs' energetic strategy does not explain female dominance / Hantanirina Rasamimanana ... [et al.] -- Male sociality and integration during the dispersal process in Lemur catta : a case study / Lisa Gould -- Patterns of health, disease, and behavior among wild ringtailed lemurs, Lemur catta: effects of habitat and sex / Michelle L. Sauther ... [et al.] -- Bald lemur syndrome and the miracle tree : alopecia associated with Leucaena leucocephala at Berenty Reserve, Madagascar / Graham C. Crawford ... [et al.] -- Temporal change in tooth size among ringtailed lemurs (Lemur catta) at the Beza Mahafaly Special Reserve, Madagascar : effects of an environmental fluctuation / Frank P. Cuozzo and Michelle L. Sauther.
  • 2007 NAP
  • 2010
    Kelly Elizabeth McCann.
    Efficient DNA double-strand break (DSB) repair is essential for maintaining the stability of the genome. A single long-lived DSB can cause cell lethality (Bennett et al., 1996). Humans with defects in DSB repair are sensitive to DNA damaging agents and are predisposed to developing cancers, as exemplified by such diseases as Nijmegan breakage syndrome, Ataxia telangiectasia, and breast cancer susceptibility in women with mutations in the BRCA1 and BRCA2 genes (Duker, 2002). Repair of DNA damage requires activation of cell cycle checkpoint controls, recruitment of repair proteins to DNA lesions, and transcriptional activation of relevant genes. As shown by our data, deletion of particular histone modification genes produces sensitivity to ionizing radiation in Saccharomyces cerevisiae, suggesting a role for chromatin modification enzymes in the repair process as well. Because damage recognition and repair of lesions are both influenced by chromatin structure, we began by studying the role of histone acetylation in the DNA damage response. Acetylation of the N-terminal tails of histone H4 opens the chromatin to allow repair enzymes to access broken DNA. Through a screen of the yeast deletion pool, we found that deletion of BRE1 and DOT1 genes causes sensitivity to ionizing radiation. Ubiquitination of H2B on lysine 123 (H2B-K123) by ubiquitin ligase Bre1 is necessary for methylation of H3 on lysine 79 (H3-K79) by Dot1. Through the histone modifications they catalyze, these proteins are involved in many aspects of the DNA repair response, as outlined in Sections C, D, and E. Our studies focused on homologous recombination repair defects, genome-wide expression patterns in BRE1 and DOT1 deletion mutants, an analysis of the data regarding proteins purported to bind to methylated H3-K79, and optimization of a protein purification strategy to find Dot1 binding partners. Our yeast deletion pool screen also predicted a role for N-terminal acetyltransferase complex NatB in DNA double-strand break repair. In Section F, we build a case for acetylation of DNA end-binding protein Mre11.
  • 2005 Springer
    edited by Alois Herzig ... [et al.].
  • 2006 Springer
    edited by Jianguo Wu ... [et al.].
  • 2012
    Julie Rebecca Perlin.
    The nervous system connects cells throughout the body to coordinate actions and transmit signals. Critical to the nervous system are the neurons that extend axons to their targets and the glial cells that interact with these axons. Oligodendrocytes in the central nervous system and Schwann cells in the peripheral nervous system wrap axons to make the myelin sheath. Myelin is critical for enhancing the speed of action potentials as well as providing support to axons. Myelin was a critical adaptation that has allowed vertebrates to increase in size, precision of movement, and complexity. Insults to myelin cause devastating diseases, and a better understanding of the normal development of myelinating glia is necessary for improving treatment of human neuropathies. In this dissertation I investigate both well-known and novel signaling pathways and their roles in Schwann cell migration and myelination in zebrafish peripheral nerves. Before making myelin, Schwann cells must migrate along and cover the surface of a bundle of axons. Here, I demonstrate that Neuregulin 1 type III (Nrg 1 type III) is required in neurons to signal through ErbB receptors in Schwann cells for Schwann cell migration along the posterior lateral line nerve, a mechanosensory nerve. Further, ectopic expression of this signal in all neurons is sufficient to attract peripheral Schwann cells into the spinal cord. There appears to be distinct regulation of Schwann cell migration in different nerves of the peripheral nervous system, as migration of Schwann cells in motor nerves requires ErbB receptors but not the Nrg 1 type III ligand. Nrg1 type III does, however, control myelination in both sensory and motor nerves. Schwann cell migration is not only important to properly localize Schwann cells, but also to localize the lateral line nerve itself, which begins in the epidermis but then transitions across a basement membrane to the subepidermal space. As they migrate, Schwann cells degrade the basement membrane beneath the skin, which allows the nerve to transition out of the epidermis, and then rebuild the basement membrane after the nerve has been repositioned and protected from the disorganization that otherwise would take place if it remained in the epidermis. Finally, through analysis of a mutation that was found in a forward genetic screen for genes essential in myelination, I also identify a novel regulator of Schwann cell myelination. Together this work elucidates new roles of known genes in Schwann cell and nerve development and also identifies a novel gene required for peripheral myelination.
  • 2007 Springer
    edited by Christopher J.O. Baker and Kei-Hoi Cheung.
  • 2006 Springer
    K.N. Michailova, K.G. Usunoff.
  • 2007
    Jan A. Pechenik.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Sara Elaine Brownell.
    This thesis explores the use of small heat shock proteins as anti-inflammatory therapeutics in the context of neurological diseases, specifically multiple sclerosis (MS) and stroke. The family of small heat shock proteins (sHSPs) has been extensively studied as intracellular molecular chaperones. However, recent studies looking at the role of sHSPs in neurological diseases have demonstrated a near universal upregulation of certain sHSPs in damaged and diseased brains. Initially, it was thought that sHSPs are pathological in these disease states, but transgenic overexpression and exogenous administration of sHSPs in various experimental disease paradigms have shown just the contrary -- that sHSPs are protective, not pathological. In this thesis, I have found that members of the family of sHSPs are protective and therapeutic in mouse models of multiple sclerosis and stroke, experimental autoimmune encephalomyelitis (EAE) and middle cerebral artery occlusion (MCAO), respectively. Alpha B crystallin (cryab), a member of the sHSP family, is elevated in stroke and deficiency of cryab leads to worse disease outcome, illustrating the protective role of alpha B crystallin. Exogenous administration of small heat shock proteins, including alpha B crystallin, decreases disease severity by modulating the immune system. This leads to the conclusion that sHSPs are endogenous anti-inflammatory and neuroprotectant molecules produced after neurological disease, whose beneficial properties can be augmented when administered therapeutically.
  • 2008 Springer
    Eckart Eich.
  • 2012
    Alexander Gray Vaughan.
    This thesis encompasses three projects at the intersection of genetics, behavior, and neurobiology in the fruitfly, Drosophila melanogaster. The major work presented is an investigation of the afferent auditory system in D. melanogaster. The afferent auditory system of D. melanogaster arises from the Johnston's Organ in the second antennal segment, from which mechanosensory neurons project to a protocerebral region known as the Antennomechanosensory and Motor Complex (AMMC). The antennal mechanosensory system in Drosophila is used in multiple contexts, including vestibular mechanosensation, wind sensitivity, and courtship hearing. During courtship, male flies present a stereotypic pulse song as well as a hum-like sine-song to female flies; these stimuli are species-specific and critical to female receptivity. Using a large enhancer-Gal4 collection, I identify 12 candidate cell types within the AMMC, divided into 7 types of projection neurons as well as 5 types of local AMMC interneurons. I tested each of these cell types for its effect on courtship hearing by testing the effect of neuronal silencing on a) female receptivity, and b) a male locomotor response (Song-Induced Locomotion). These tests reveal that the activity of one class of projection neuron (aPN1), and one class of local interneuron (aLN(al)) are critical to courtship hearing in both male and female flies. Other cell types appear to be dispensable for courtship hearing, and may play a role in non-courtship related mechanosensation. To help confirm that these phenotypes are not specific to neuronal silencing, I also hyperactivated each cell type using the temperature-sensitive dTrpA1 reagent; these results confirm that aPN1 and aLN(al) alone are necessary for courtship hearing. Overall this work identifies a set of parallel pathways from the AMMC leading to the ventrolateral protocerebrum (VLPR), but reveal that only one of these pathways is necessary for courtship hearing. The structure of this circuit is analogous to the multi-lineage projection identified in D. melanogaster olfaction, in which a parallel pathways share a common projection but carry independent information. In addition to this work, I also discuss an investigation of the role of abnormal-chemosensory jump 6 (acj6) on escape behaviors, as well as an investigation of the expression of doublesex (dsx) in the nervous system.
  • 2009
    John S. Wilkins.
    In this comprehensive work, John S. Wilkins traces the history of the idea of "species" from antiquity to today, providing a new perspective on the relationship between philosophical and biological approaches.--[Book cover].
  • 2006 Springer
    Brian Fry.
  • 2005- SpringerLink
  • 2011
    Kerri A. Spilker.
    Specification and assembly of synapses is a highly coordinated and regulated process. Knowledge of the position and connectivity of all C. elegans neurons makes it a highly useful organism for studying the underlying mechanisms that control synapse formation. Using cell-specific promoters and fluorescently-labeled synaptic vesicle proteins, we are able to monitor synapse formation in subsets of C. elegans neurons. Close observation of synapse formation in a single posterior motorneuron (DA9) led to the identification of a mutation in the alternative splicing regulator mbl-1 that changes the synaptic pattern. The cholinergic motorneuron DA9 is required for backwards locomotion and forms ~25 synapses onto both inhibitory neurons and body wall muscles in the dorsal nerve cord (DNC) of the worm. We found that the 10 most distal synapses of DA9 fail to form in mbl-1 mutants, visualized with the synaptic vesicle-associated protein RAB-3 and the active zone proteins SYD-2/liprin-[Alpha] and UNC-10/Rim. In addition, some RAB-3 mis-localizes to the dendrite of DA9 and animals have a backwards locomotion defect consistent with a loss of synapses onto dorsal body wall muscles. mbl-1 is a member of the conserved MBNL (Muscleblind like) family of CCCH zinc-finger RNA binding proteins that regulate alternative splicing of target genes by directly binding to target mRNA. In the human disease myotonic dystrophy type 1 (DM1), a progressive muscular dystrophy, sequestration of MBNL proteins in nuclear foci leads to altered splicing of downstream genes. Mis-splicing of several genes is responsible for the muscular and cardiac symptoms present in individuals with DM1. Most work on the MBNL proteins has focused on their role in muscle morphogenesis and maintenance. However, C. elegans mbl-1 is expressed in a subset of motorneurons including DA9 and is required cell autonomously in these neurons to regulate proper synapse formation. Post-synaptic and muscle markers were unaffected in mbl-1 mutant animals. Thus, our work demonstrates that mbl-1 also functions in neurons to regulate synapse formation. In a separate set of experiments, we identified a new mutation in the coding region of the touch cell-specific beta-tubulin, mec-7(wy116) that causes a defect in synapse formation in the mechanosensory neuron PLM. Previous studies have shown that mec-7 is expressed exclusively in the six touch neurons of C. elegans and is required for sensing light touch. Our mec-7 mutation leads to a loss of synaptic vesicle accumulation at PLM synaptic sites in the ventral nerve cord and synaptic vesicles are visible at ectopic locations along the lateral axon of PLM. Localization of the synaptic proteins VAMP and GIT-1 is also defective in our mutant, but neuronal morphology is wild-type. mec-7(wy116) is mildly Mec, but other alleles of mec-7 (e1506, e1527) do not phenocopy the synaptic vesicle localization defect. mec-7(wy116) is a missense mutation that alters a highly conserved Thr at position 409 to Ile. Crystal structures of tubulin indicate that this residue is on the face of tubulin that interacts with kinesin motor. Because we see synaptic vesicles along the lateral axon of PLM, we believe that kinesin-mediated vesicle transport is less efficient in mec-7(wy116) mutants.
  • 2013 ScienceDirect
    edited by Huimin Zhao.
    Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms. Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomesHighlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications. Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.
  • 2013 Springer
    Michael G. Katze, editor.
    First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.
  • 2007 Springer
    edited by Mohamed Al-Rubeai and Martin Fussenegger.
  • 2007 Springer
    P. Bringmann, E.C. Butcher, G. Parry, B. Weiss, editors.
  • 2007 CRCnetBASE
    edited by Andrzej K. Konopka.
    Basic concepts of systems biology / Andrzej K. Konopka -- Understanding through modeling : a historical perspective and review of biochemical systems theory as a powerful tool for systems biology / Eberhard O. Voit and John H. Schwacke -- Thermostatics : a poster child of systems thinking / Peter Salamon, Anna Salamon, and Andrzej K. Konopka -- Friesian epistemology / Kelley L. Ross -- Reconsidering the notion of the organic / Robert E. Ulanowicz -- The metaphor of "chaos" / Wlodzimierz Klonowksi -- Biological complexity : an engineering perspective / Stephen W. Kercel -- The von Neumann's self-replicator and a critique of its misconceptions / Stephen W. Kercel -- The mathematical structure of thermodynamics / Peter Salamon ... [et al.].
  • v. 1-, 2010- Springer
    Choi, Sangdun.
  • 2007 MyiLibrary
    edited by Isidore Rigoutsos and Gregory Stephanopoulos.
  • 2007 Springer
    edited by John A. Bissonette, Ilse Storch.
  • An online journal and ebook service of the Thieme Publishing Group. The ebook package is also called Thieme Clinical Collections.
  • v. 2-, 2005- Springer
    Bronner, Felix; Farach-Carson, Mary C.
  • v.1-2=, 2014 CRCnetBASE
    v.2 (2014) CRCnetBASE
    editor, Gian Paolo Rossini.
    Structured account of the existing knowledge of toxic algae, the chemistry of the toxins they produce, the effects these substances exert in humans and wildlife, as well as the strategies envisaged to protect public health and the environment. Covers recent advances in the understanding of the biology of toxin producers and the factors involved in the appearance and dynamics of harmful algae blooms, the factors affecting toxin production, the synthesis of toxins both in natural producers and by chemical means in a lab, and the toxin groups posing continuing and novel. Studies effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities.
  • 2006 Springer
    edited by Jacques Brodeur and Guy Boivin.
  • 2008 CRCnetBASE
    Hugh Cartwright ; chapter 10, Evolvable developmental systems, contributed by Nawwaf Kharma.
  • 2012
    Alan Hunter Shain.
    Pancreatic ductal adenocarcinoma, subsequently referred to as pancreatic cancer, is one of the most deadly cancers with a five-year survival of only 5%. Typical treatment regimens include surgery and chemotherapy while targeted therapies are lacking. A better understanding of the underlying cancer biology may yield novel therapeutic targets. The field of genomics has transformed our ability to study cancer. Over the past two decades, microarray and sequencing based innovations have enabled biology to be carried out at the --omic scale (discussed further in Chapter 1). This dissertation employs --omic level analysis to query the differences between the pancreatic cancer genome and the normal human genome. First, high throughput structural characterizations were performed in order to annotate the mutated, rearranged, deleted, and amplified genes across seventy pancreatic cancers. These assays identified hundreds of candidate cancer genes. Among these candidates, SMURF1 was validated to be an oncogene (Chapter 2). Furthermore, various subunits of the SWI/SNF chromatin remodeling complex were validated to be tumor suppressor genes (Chapter 3). While SMURF1 and SWI/SNF were validated individually, the other candidates from structural studies were evaluated in parallel shRNA competive growth screen. From this, we characterize nine genes further -- some previously known to play a role in cancer and some novel (Chapter 4). The sum total of all of this work is a much deeper understanding of the biology of pancreatic cancer, yielding many novel therapeutic targets and hopefully allowing scientists to gain a foothold in the fight against this disease.
  • 2016 Springer
    H.G. Stratmann.
  • 2005 Springer
    Michael Markussen ... [et al.].
  • 2008 Springer
    Boris Bogdan, Ralph Villiger.

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