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  • Adenosine and Metabolism--A Brief Historical Note / Bertil B. Fredholm -- Adenosine Metabolism, Adenosine Kinase, and Evolution / Jaoek Park and Radhey S. Gupta -- Adenosine and Energy Metabolism--Relationship to Brain Bioenergetics / Xuesong Chen, Liang Hui and Jonathan D. Geiger -- Adenosine and Autocrine Metabolic Regulation of Neuronal Activity / Masahito Kawamura Jr. and David N. Ruskin -- Physiologic and Metabolic Regulation of Adenosine: Mechanisms / Chris G. Dulla and Susan A. Masino -- The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books / Stephanie zur Nedden, Alexander S. Doney and Bruno G. Frenguelli -- Downstream Pathways of Adenosine / Ana M. Sebastião, Sofia Cristóvão-Ferreira and Joaquim A. Ribeiro -- Astrocytic ATP Release / Dustin J. Hines and Philip G. Haydon -- Role of Striatal A2A Receptor Subpopulations in Neurological Disorders / Sergi Ferré, César Quiroz, Marco Orrú, Xavier Guitart and Seema Gulyani, et al. -- Sleep and Adenosine: Human Studies / Tarja Porkka-Heiskanen -- Adenosine and Other Purinergic Products in Circadian Timing / Christine Muheim and Steven A. Brown -- Adenosine in the Immune System / György Hask, Balázs Koscsó́ and Balázs Csóka -- The Bioenergetic Network of Adenosine in Hibernation, Sleep, and Thermoregulation / Kelly L. Drew and Tulasi R. Jinka -- Adenosine and Stroke / Felicita Pedata, Anna Maria Pugliese, Francesca Corti and Alessia Melani -- The Many Roles of Adenosine in Traumatic Brain Injury / Patrick M. Kochanek, Jonathan D. Verrier, Amy K. Wagner and Edwin K. Jackson -- Therapeutic Perspectives of Adenosine Receptor Compounds in Functional Restitution After Spinal Cord Injury / Kwaku D. Nantwi -- Adenosine and Pain / Jana Sawynok -- Symptomatic and Neuroprotective Effects of A2A Receptor Antagonists in Parkinson's Disease / Annalisa Pinna, Nicola Simola, Lucia Frau and Micaela Morelli -- Adenosine Receptors and Alzheimer's Disease / David Blum, Ursula Sandau, Cyril Laurent, Vânia Batalha and Antoine Leboucher, et al. -- Adenosine Receptors in Huntington's Disease / David Blum, Alberto Martire, Sylvie Burnouf, Bernard Sablonnière and Pierre Krystkowiak, et al. -- Adenosine and Multiple Sclerosis / Maria Victoria Sánchez-Gómez, Estibaliz González-Fernández, Rogelio O. Arellano and Carlos Matute -- Adenosinergic Perspectives on Schizophrenia: Opportunity for an Integrative Synthesis / Benjamin K. Yee, Philipp Singer and Detlev Boison -- The Role of Adenosine in the Ventral Striatal Circuits Regulating Behavioral Activation and Effort-Related Decision Making: Importance for Normal and Pathological Aspects of Motivation / John D. Salamone, Merce Correa, Patrick A. Randall, Eric J. Nunes and Marta Pardo, et al. -- Adenosine and Autism: Physiological Symptoms and Metabolic Opportunities / Julia Svedova, Inge-Marie Eigsti and Susan A. Masino -- Stress, Brain Adenosine Signaling, and Fatigue-Related Behavioral Processes / Traci N. Plumb, Sarah R. Sterlace, Kelly A. Cavanaugh and Thomas R. Minor -- Disruption of Adenosine Homeostasis in Epilepsy and Therapeutic Adenosine Augmentation / Detlev Boison -- Ketogenic Diet and Epilepsy: The Role of Adenosine / Jong M. Rho, Beth Zupec-Kania and Susan A. Masino -- Silk: A Biocompatible and Biodegradable Biopolymer for Therapeutic Adenosine Delivery / Eleanor M. Pritchard, Detlev Boison and David L. Kaplan -- Anatomical Distribution of Nucleoside System in the Human Brain and Implications for Therapy / Zsolt Kovács and Arpád Dobolyi.
  • Also available: Print – 2012
    Part 1. Multiscale biological networks: identification, modeling and analysis -- Modular Analysis of Biological Networks / Hans-Michael Kaltenbach and Jörg Stelling -- Modeling Signaling Networks Using High-throughput Phospho-proteomics / Camille Terfve and Julio Saez-Rodriguez -- An Integrated Bayesian Framework for Identifying Phosphorylation Networks in Stimulated Cells / Tapesh Santra, Boris Kholodenko and Walter Kolch -- Signaling Cascades: Consequences of Varying Substrate and Phosphatase Levels / Elisenda Feliu, Michael Knudsen and Carsten Wiuf -- Heterogeneous Biological Network Visualization System: Case Study in Context of Medical Image Data / Erno Lindfors, Jussi Mattila, Peddinti V. Gopalacharyulu, Antti Pesonen and Jyrki Lötjönen, et al. -- Evolution of the Cognitive Proteome: From Static to Dynamic Network Models / J. Douglas Armstrong and Oksana Sorokina -- Molecular Systems Biology of Sic1 in Yeast Cell Cycle Regulation Through Multiscale Modeling / Matteo Barberis -- Proteome-Wide Screens in Saccharomyces cerevisiae Using the Yeast GFP Collection / Yolanda T. Chong, Michael J. Cox and Brenda Andrews -- Unraveling the Complex Regulatory Relationships Between Metabolism and Signal Transduction in Cancer / Michelle L. Wynn, Sofia D. Merajver and Santiago Schnell -- Part 2. Cellular decision making: adaptation, differentiation and death -- The Cell as a Thermostat: How Much does it Know? / Dennis Bray -- Stem Cell Differentiation as a Renewal-Reward Process: Predictions and Validation in the Colonic Crypt / Kiran Gireesan Vanaja, Andrew P. Feinberg and Andre Levchenko -- A Dynamic Physical Model of Cell Migration, Differentiation and Apoptosis in Caenorhabditis elegans / Antje Beyer, Ralf Eberhard, Nir Piterman, Michael O. Hengartner and Alex Hajnal, et al. -- A Modular Model of the Apoptosis Machinery / E. O. Kutumova, I. N. Kiselev, R. N. Sharipov, I. N. Lavrik and Fedor A. Kolpakov -- An Ensemble Approach for Inferring Semi-quantitative Regulatory Dynamics for the Differentiation of Mouse Embryonic Stem Cells Using Prior Knowledge / Dominik Lutter, Philipp Bruns and Fabian J. Theis -- Cell Death and Life in Cancer: Mathematical Modeling of Cell Fate Decisions / Andrei Zinovyev, Simon Fourquet, Laurent Tournier, Laurence Calzone and Emmanuel Barillot -- Theoretical Aspects of Cellular Decision-Making and Information-Processing / Tetsuya J. Kobayashi and Atsushi Kamimura -- Zooming in on Yeast Osmoadaptation / Clemens Kühn and Edda Klipp -- Part 3. Spatial and temporal dymensions of intracellular dynamics -- Receptor Dynamics in Signaling / Verena Becker, Jens Timmer and Ursula Klingmüller -- A Systems-Biology Approach to Yeast Actin Cables / Tyler Drake, Eddy Yusuf and Dimitrios Vavylonis -- Modeling Morphodynamic Phenotypes and Dynamic Regimes of Cell Motion / Mihaela Enculescu and Martin Falcke -- Time-Structure of the Yeast Metabolism In vivo / Kalesh Sasidharan, Masaru Tomita, Miguel Aon, David Lloyd and Douglas B. Murray -- Coarse Graining Escherichia coli Chemotaxis: From Multi-flagella Propulsion to Logarithmic Sensing / Tine Curk, Franziska Matthäus, Yifat Brill-Karniely and Jure Dobnikar -- Self-Feedback in Actin Polymerization / Anders E. Carlsson -- Part 4. Computational tools, algorithms and theoretical methods for systems biology -- Global Optimization in Systems Biology: Stochastic Methods and Their Applications / Eva Balsa-Canto, J. R. Banga, J. A. Egea, A. Fernandez-Villaverde and G. M. de Hijas-Liste -- Mathematical Modeling of the Human Energy Metabolism Based on the Selfish Brain Theory / Matthias Chung and Britta Göbel -- Identification of Sensitive Enzymes in the Photosynthetic Carbon Metabolism / Renato Umeton, Giovanni Stracquadanio, Alessio Papini, Jole Costanza and Pietro Liò, et al. -- Formal Methods for Checking the Consistency of Biological Models / Allan Clark, Vashti Galpin, Stephen Gilmore, Maria Luisa Guerriero and Jane Hillston -- Global Parameter Identification of Stochastic Reaction Networks from Single Trajectories / Christian L. Müller, Rajesh Ramaswamy and Ivo F. Sbalzarini -- A Systems Biology View of Adaptation in Sensory Mechanisms / Pablo A. Iglesias -- Leveraging Modeling Approaches: Reaction Networks and Rules / Michael L. Blinov and Ion I. Moraru -- Part 5. Applications of systems biology in medicine, biotechnology and pharmaceutical industry -- Why and How to Expand the Role of Systems Biology in Pharmaceutical Research and Development / Robert D. Phair -- Multiscale Mechanistic Modeling in Pharmaceutical Research and Development / Lars Kuepfer, Jörg Lippert and Thomas Eissing -- Re-analysis of Bipolar Disorder and Schizophrenia Gene Expression Complements the Kraepelinian Dichotomy / Kui Qian, Antonio Di Lieto, Jukka Corander, Petri Auvinen and Dario Greco -- Bringing Together Models from Bottom-Up and Top-Down Approaches: An Application for Growth of Escherichia coli on Different Carbohydrates / Andeas Kremling -- A Differential Equation Model to Investigate the Dynamics of the Bovine Estrous Cycle / H. M. T. Boer, C. Stötzel, S. Röblitz and H. Woelders -- Reducing Systems Biology to Practice in Pharmaceutical Company Research; Selected Case Studies / N. Benson, L. Cucurull-Sanchez, O. Demin, S. Smirnov and P. van der Graaf -- System-Scale Network Modeling of Cancer Using EPoC / Tobias Abenius, Rebecka Jörnsten, Teresia Kling, Linnéa Schmidt and José Sánchez, et al. -- Early Patient Stratification and Predictive Biomarkers in Drug Discovery and Development / Daphna Laifenfeld, David A. Drubin, Natalie L. Catlett, Jennifer S. Park and Aaron A. Van Hooser, et al. -- Biomedical Atlases: Systematics, Informatics and Analysis / Richard A. Baldock and Albert Burger.
  • Complementarity of species distributions as a tool for prioritising conservation actions in Africa : testing the efficiency of using coarse-scale distribution data / J. Fjeldså, H. Tushabe -- Scorpion diversity and distribution in southern Africa : pattern and process / L. Prendini -- Madagascar as a model region for the study of tempo and pattern in adaptive radiations / M. Vences -- Commemorating Martin Eisentraut (1902-1994) - important explorer of tropical African vertebrates / W. Böhme -- Earwigs (Dermaptera:Insects) of Kenya : checklist and species new to Kenya / F. Haas ... [et al.] -- Morphometric differentiation in the East African grasshopper genus Afrophlaebo Jago, 1983 (Orthoptera:Acrididae) / A. Hochkirch -- Katydids and crickets (Orthoptera: Ensifera) of the Kakamega Forest Reserve, western Kenya / J. Holstein ... [et al.] -- Ecology and diversity of canopy associated Ceratocanthidae (Insecta:Coleoptera, Scarabaeoidea) in an Afrotropical rainforest / A. Ballerio, T. Wagner -- Human influence on the dung fauna in Afrotropical grasslands (Insecta:Coleoptera) / F.-T. Krell ... [et al.] -- Genuine Africans or Tertiary immigrants? : the genus Hydropsyche in the Afrotropical region (Insecta, Trichoptera:Hydropsychidae) / W. Mey -- Fruit-feeding butterfly communities of forest 'islands' in Ghana : survey completeness and correlates of spatial diversity / J.L. Bossart ... [et al.] -- Biogeography, diversity, and ecology of sawflies in the Afromontane region (Insecta: Symphyta) / F. Koch -- Diversity, distribution patterns, and endemism of southern African bees (Hymenoptera:Apoidea) / M. Kuhlmann -- Does grazing influence bee diversity? / C. Mayer -- The pholcid spiders of Africa (Araneae:Pholcidae) : state of knowledge and directions for future research / B.A. Huber -- West African fish diversity : distribution patterns and possible conclusions for conservation strategies / T. Moritz, K.E. Linsenmair -- Distribution and population density of the black-eared Malagasy poison frog, Mantella milotympanum Staniszewski, 1996 (Amphibia:Mantellidae) / D.R. Vieites ... [et al.] -- Amphibian and reptile diversity in the Southern Udzungwa Scarp Forest Reserve, south-eastern Tanzania / M. Menegon, S. Salvidio -- Interpreting morphological and molecular data on Indian Ocean giant tortoises / J. Gerlach -- Molecular systematics of African Colubroidea (Squamata:Serpentes) / Z.T. Nagy ... [et al.] -- How to digitize large insect collections : preliminary results of the DIG project / K.-H. Lampe, D. Striebing -- Monitoring landcover changes of the Niger inland delta ecosystem (Mali) by means of ENVISAT-MERIS data / R. Seiler, E. Csaplovics, E. Vollmer -- Is geodiversity correlated to biodiversity? : a case study of the relationship between spatial heterogeneity of soil resources and tree diversity in a western Kenyan rainforest / W. Musila ... [et al.] -- Decline of woody species in the Sahel / A. Wezel -- Diversity over time and space in enset landraces (Ensete ventricosum) in Ethiopia / K. Zippel. Phylogeny and biogeography of Malagasy dwarf geckos, Lygodactylus Gray, 1864 : preliminary data from mitochondrial DNA sequences (Squamata:Gekkonidae) / M. Puente, M. Thomas, M. Vences -- Variability in a common species : the Lygodactylus capensis complex from southern and eastern Africa (Reptilia, Gekkonidae) / B. Röll -- Migration within and out of Africa : identifying knowledge gaps by data-mining the Global Register of Migratory Species / K. Riede -- Avifaunal responses to landscape-scale habitat fragmentation in the littoral forests of south-eastern Madagascar / J.E.M. Watson -- Use of satellite telemetry and remote sensing data to identify important habitats of migratory birds (Ciconia ciconia (Linnaeus 1758)) / B. Gerkmann, K. Riede -- Conservation priorities and geographical variation in flycatchers (Aves:Platysteiridae) in the Democratic Republic of Congo / M. Louette -- Rare weavers (Aves:Ploceidae) : are some Ploceus species hybrids? / A.J.F.K. Craig -- Historical determinants of mammal diversity in Africa : evolution of mammalian body mass distribution in Africa and South America during Neogene and Quaternary times / M. Nieto ... [et al.] -- Diversity and abundance of diurnal primates and forest antelopes in relation to habitat quality : a case study from the Udzungwa Mountains of Tanzania / F. Rovero, A.R. Marshall -- Small mammal diversity and reproduction along a transect in Namibia (BIOTA S 07) / P. Giere, U. Zeller -- Possible karyological affinities of small mammals from north of the Ethiopian Plateau / N. Sh. Bulatova, L.A. Lavrenchenko -- Geographic variation in the West African scaly-tailed squirrel Anomalurus pelii (Schlegel and Müller, 1845) and description of a new subspecies (Rodentia:Anomaluridae) / A.C. Schunke, R. Hutterer -- Middle ear ossicles as a diagnostic trait in African mole-rats (Rodentia:Bathyergidae) / S. Lange ... [et al.] -- Community analysis of Muridae (Mammalia, Rodentia) diversity in Guinea : a special emphasis on Mastomys species and Lassa fever distributions / C. Denys ... [et al.] -- Effects of different land use on the parasite burden and MHC constitution of two rodent species (Gerbillurus paeba, Rhabdomys pumilio) in the southern Kalahari desert / R. Harf, G. Froeschke, S. Sommer -- An assessment of the systematics of the genus Desmomys Thomas, 1910 (Rodentia:Muridae) using mitochondrial DNA sequences / L.A. Lavrenchenko, E. Verheyen -- Integrative taxonomy and phylogenetic systematics of the genets (Carnivora, Viverridae, Genetta) : a new classification of the most speciose carnivoran genus in Africa / P. Gaubert, P.J. Taylor, G. Veron --
  • Deliberation and Democracy -- Plato Was Not So Far Wrong: Recalling Athenian Democracy -- A Reappraisal of the Medieval Approach Will Lead to Excellent Deliberators -- Beware of Those Who Think They Possess the Truth! -- Let Us Learn How to Deliberate before Deliberating! -- Between Ethics and Biomedicine.
  • The global biodiversity information facility (GBIF) / Meredith A. Lane and James. L. Edwards -- The European network for biodiversity information / Wouter Los and Cees H.J. Hof -- Networking taxonomic concepts--uniting without 'unitary-ism' / Walter G. Berendsohn and Mark Geoffrey -- Networking biological collections databases : building a European infrastructure / Malcolm J. Scoble and Walter G. Berendsohn -- A comparison between morphometric and artifical neural network approaches to the automated species recognition problem in systematics / Norman MacLeod, M. O'Neill, and Steven A. Walsh -- Automated extraction of biodiversity data from taxonomic descriptions / Gordon B. Curry and Richard J. Connor -- The grid and biodiversity informatics / Andrew C. Jones -- LIAS--an interactive database system from structured descriptive data of ascomycetes / Dagmar Triebel ... [et al.] -- Linking biodiversity databases : preparing species diversity information sources by assembling, merging and linking databases / Richard J. White -- Priority areas for rattan conservation on Borneo / Jacob Andersen Sterling ... [et al].
  • Print Material
  • The southern ocean -- Phytoplankton and primary production -- Sea-ice microbial communities -- Zooplankton -- Krill -- Nekton -- Fish -- Seals -- Whales -- Birds -- Benthic communities -- The fast ice and ice shelves -- Ice-edge processes -- Decomposition and the roles of bacteria and protozoa -- Ecosystem dynamics -- Resource exploitation -- Ecosystem changes resulting from resource exploitation -- Management of living resources -- Ultraviolet radiation -- Global warming and Antarctic marine ecosystems -- Human impact.
  • Biology of turtles 2008
    How the turtle gets its shell / Scott F. Gilbert, Judith A. Cebra-Thomas, and Ann C. Burke -- Comparative ontogenetic and phylogenetic aspects of Chelonian chondro-osseous growth and skeletochronology / Melissa L. Snover and Anders G.J. Rhodin -- Evolution and structure of the turtle shell / Peter C.H. Pritchard -- Long bone allometry in tortoises and turtles / Gustavo A. Llorente ... [et al.] -- Evolution of locomotion in aquatic turtles / Sabine Renous ... [et al.] -- Hindlimb function in turtle locomotion : limb movements and muscular activation across taxa, environment, and ontogeny / Richard W. Blob, Angela R.V. Rivera, and Mark W. Westneat -- Cervical anatomy and function in turtles / Anthony Herrel, Johan Van Damme, and Peter Aerts -- Functional evolution of feeding behavior in turtles / Vincent Bels ... [et al.] -- The structure of cardiopulmonary systems of turtles : implications for behavior / Jeanette Wyneken -- Reproductive structures and strategies of turtles / Jeffrey D. Miller and Stephen A. Dinkelacker -- Mixed and uniform brood sex ratio strategy in turtles : the facts, the theory, and their consequences / Vincent Hulin ... [et al.] -- The physiology and anatomy of anoxia tolerance in the freshwater turtle brain / Sarah L. Milton -- The relationships of turtles with amniotes / Olivier Rieppel.
  • "The volume is intended as an introduction to the physical principles governing the main processes that occur in photosynthesis, with emphasis on the light reactions and electron transport chain. A unique feature of the photosynthetic apparatus is the fact that the molecular structures are known in detail for essentially all of its major components. The availability of this data has allowed their functions to be probed at a very fundamental level to discover the design principles that have guided evolution. Other volumes on photosynthesis have tended to focus on single components or on a specific set of biophysical techniques, and the authors' goal is to provide new researchers with an introduction to the overall field of photosynthesis. The book is divided into sections, each dealing with one of the main physical processes in photosynthetic energy conversion. Each section has several chapters each describing the role that a basic physical property, such as charge or spin, plays in governing the process being discussed. The chapters proceed in an orderly fashion from a quantum mechanical description of early processes on an ultrafast timescale to a classical treatment of electron transfer and catalysis on a biochemical timescale culminating in evolutionary principles on a geological timescale."--Publisher's website.
  • The bonobo's adaptive potential : social relations under captive conditions / Jeroen M.G. Stevens, Hilde Vervaecke and Linda Van Elsacker -- What does agonistic dominance imply in bonobos? / Tommaso Paoli and Elisabetta Palagi -- Social play in bonobos : not only an immature matter / Elisabetta Palagi and Tommaso Paoli -- Gestures and multimodal signaling in bonobos / Amy S. Pollick, Annette Jeneson and Frans B.M. de Waal -- Longitudinal structure of a unit-group of bonobos : male philopatry and possible fusion of unit-groups / Chie Hashimoto ... [et al.] -- Seasonal changes in fruit production and party size of bonobos at Wamba / Mbangi Mulavwa ... [et al.] -- Relationships among fruit abundance, ranging rate, and party size and composition of bonobos at Wamba / Takeshi Furuichi ... [et al.] -- Bonobo (Pan paniscus) density estimation in the SW-Salonga National Park, Democratic Republic of Congo : common methodology revisited / Meike Mohneke and Barbara Fruth -- Ecological factors influencing bonobo density and distribution in the Salonga National Park : applications for population assessment / Gay Edwards Reinartz ... [et al.] -- Range occupation and population estimates of bonobos in the Salonga National Park : application to large-scale surveys of bonobos in the Democratic Republic of Congo / Falk Grossmann ... [et al.] -- Traditional land-use practices for bonobo conservation / Jo Myers Thompson, Lubuta Mbokoso Nestor and Richard Bovundja Kabanda -- Human hunting and its impact on bonobos in the Salonga National Park, Democratic Republic of Congo / John A. Hart ... [et al.] -- The bonobos of the Lake Tumba-Lake Maindombe hinterland : threats and opportunities for population conservation / Bila-Isia Inogwabini ... [et al.] -- Changes in the status of bonobos, their habitat, and the situation of humans at Wamba in the Luo Scientific Reserve, Democratic Republic of Congo / Gen'ichi Idani ... [et al.] -- The conservation value of Lola ya Bonobo sanctuary / Claudine André ... [et al.].
  • Overview of the respiratory system / S.C. Wood -- Control of respiration in aquatic vertebrates: Gas transport and gill function in water-breathing fish / S.F. Perry ... [et al.]. Patterns of acid-base regulation during exposure to hypercarbia in fishes / C.J. Brauner and D.W. Baker. Buoyancy control in aquatic vertebrates / B. Pelster. Gas exchange and control of respiration in air-breathing teleost fish / M.L. Glass and F.T. Rantin. Effects of temperature on cardiac function in teleost fish / A.L. Kalinin ... [et al.]. Physiological evidence indicates lungfish as a sister group to the land vertebrates / M.L. Glass. Aestivation in amphibians, reptiles, and lungfish / M.L. Glass, J. Amin-Naves, and G.S.F. da Silva -- Evolution of pulmonary mechaincs and respiratory control: Trade-offs in the evolution of the respiratory apparatus of chordates / S.F. Perry, W. Klein, and J.R. Codd. Environmental selection pressures shaping the pulmonary surfactant system of adult and developing lungs / S. Orgeig and C.B. Daniels. Midbrain structures and control of ventilation in amphibians / L.H. Gargaglioni and L.G.S. Branco. Comparative aspects of hypoxia tolerance of the ectothermic vertebrate heart / H. Gesser and J. Overgaard. Control of the heart and of cardiorespiratory interactions in ectothermic vertebrates / E.W. Taylor and T. Wang. The endocrine-paracrine control of the cardiovascular system / B. Tota and M.C. Cerra. Stoking the brightest fires of life among vertebrates / Raul K. Suarez and Kenneth C. Welch -- Respiratory physiology of birds : metabolic control: Prenatal development of cardiovascular regulation in avian species / J. Altimiras, D.A. Crossley II, and E. Villamor. Control of breathing in birds : implications for high-altitude flight / G.R. Scott and W.K. Milsom -- Mammalian and human physiology: Peripheral chemoreceptors in mammals : structure, function and transduction / P. Kumar. Central chemosensitivity in mammals / L.K. Hartzler and R.W. Putnam. Human exercise physiology / S. Volianitis and Niels H. Secher.
  • The brain is a complex organ formed from billions of neurons. There are thousands of types of neurons, each with a unique morphology, function, gene expression profile and pattern of connectivity. This structure poses a very interesting developmental challenge: how do neurons acquire unique identities and connect to specific partner neurons during development? The Drosophila antennal lobe presents an attractive genetic model system in which to investigate these questions. In the antennal lobe, olfactory receptor neuron (ORN) axons project to glomeruli where they synapse with their partner projection neuron (PN) dendrites. These connections are highly stereotyped, as ORNs expressing the same odorant receptor converge on the same glomerulus and all PNs of the same class send their dendrites to the same glomerulus. Cell surface molecules are known to be crucial to instructing this specific wiring during development, and a transcriptional code likely dictates which cells express a particular cell surface molecule. However, the identities of many of these cell surface molecules and transcription factors remain unknown, and it is possible that additional cell types also inform the specific wiring of PNs and ORNs. In this thesis, I present work that furthers our understanding of the development and function of the fly olfactory circuit. First, I discuss a detailed characterization of local interneurons in the antennal lobe, dramatically expanding our basic knowledge of the types of cells present during development as well as central to information processing in the antennal lobe. Second, I present my work on the transcription factor longitudinals lacking (lola) that plays a role both in fate determination and wiring specificity of olfactory projection neurons, the second order cells that relay olfactory information to higher brain centers. Finally, I present an analysis of the regulatory elements driving expression of the projection neuron marker GH146 as a first step in defining transcriptional regulatory modules and identifying factors that may direct fate and wiring decisions in PNs.
  • The Chibby protein antagonizes Wnt/Beta-Catenin signaling, a prominent regulator pathway of development, via direct interaction with the transcriptional activator domain of Beta-Catenin. Chibby mutant mice have a defect in the formation of motile cilia in the airway epithelium. The centrosome is the major microtubule organizing center of animal cells and includes two centrioles, termed mother and the daughter based on their age and replicative history. The mother harbors subdistal and distal appendages, which, respectively, anchor the interphase microtubule array and are required for ciliation. Several lines of published evidence suggest a link between the primary cilium, a single, non-motile structure found on many cells, and Wnt/Beta-Catenin signaling. Based on this evidence I investigated Chibby, and related members of the Chibby protein family, to determine its role in centrosome and cilium structure and function. I report here that the Chibby family of proteins is associated physically and functionally with the centrioles of the centrosome in mammalian cells. The Chibby family consists of Chibby (Cby1), Nurit/Cby2, and the previously uncharacterized, Chibby3 (Cby3). Fluorescence microscopy revealed that Cby1 localized to the mother centriole of the centrosome, and that this localization was partially shared with Nurit/Cby2 and Cby3. Cby1 colocalizes at the mother centriole with phospho-Beta-Catenin, a modified form of Beta-Catenin that, in some contexts it is targeted for proteasome-mediated degradation. I also found that Cby1 partially colocalized with phospho-Beta-Catenin at a ring-like structure at the midbody during cytokinesis, where they might regulate abscission. The localization of Cby1 to the mother centriole was similar to that described for proteins for the distal appendages of the mother centriole. I found that Cby1 colocalized with, and exhibited cell cycle dynamics similar to, Cep164, a known distal appendage protein that is required for primary cilium formation. Consistent with a role for Cby1 in these centriolar structures, Cby1-/- mouse embryonic fibroblasts exhibited a strong reduction in primary cilium formation that could be complemented by expression of the wild-type Cby1 protein. Remarkably, overexpression of either GFP-tagged Beta-Catenin or GFP-Cby1 in hTERT-RPE1 cells resulted in fewer, but longer, cilia than controls suggesting that both of these proteins are important for structure and function of the primary cilium. In summary, I propose that Cby1 is associated with the distal appendages of the mother centriole, that defects in those structures are the likely cause of the failure of cilium formation in cells lacking Cby1, and that both primary and motile cilia display this requirement for Cby1.
  • Desmosomes are multi-protein cell-cell adhesion junctions found throughout stratified squamous epithelia and the myocardium. These specialized adhesion complexes maintain the structural integrity of these tissues, which are continuously exposed to mechanical stress. Perturbations in desmosome structure and function lead to clinical symptoms associated with a variety of human skin and heart disorders. While the molecular basis for these phenotypes is mainly attributable to the role of the desmosome in resisting mechanical stress, emerging roles for this complex in cellular signaling, apoptosis, and tissue morphogenesis are accumulating. Understanding the molecular mechanisms of desmosome function in both normal tissue homeostasis and disease will bring new insights into these complex biological processes. Loss of cellular adhesion junctions is a common feature of epithelial cancer progression. However, the specific contribution of how desmosome function affects this disease has not been looked at in great detail. In the first two chapters, we examined the consequences of desmosome loss to tumor formation using mice deficient for the desmosomal protein Perp. In-depth analyses focusing on Perp's mechanism of action revealed new insights into the role of Perp and the desmosome in adhesion, apoptosis, and inflammation. In the second part of my thesis, we investigated the role of the desmosome in epithelial wound healing and in Ankyloblepharon Ectodermal Dysplasia and Cleft Lip/Palate (AEC), a human skin disease characterized by severe craniofacial abnormalities, skin erosions, and alopecia. We first showed that proper desmosome function is essential for efficient wound healing in vivo. Lastly, we investigated whether some of the clinical symptoms associated with AEC were attributable to defects in Perp function. We identified a subset of AEC derived p63 mutants that were capable of transactiving Perp expression, despite being previously characterized as inactive for other p63 target genes. Analysis of skin biopsies revealed disrupted Perp expression in a subset of AEC patients, further corroborating a role for Perp dysfunction in the pathogenesis of this disease. Together these studies have uncovered important roles for Perp and the desmosome in maintaining proper skin homeostasis and insights into the mechanisms of how Perp loss and desmosome disruption contributes to disease progression in a variety of contexts.
  • 1. The evolution of earth-the geochemical partner of the global ecosystem (5 billion years of history) -- 2. Basic chemistry of the ecosystem -- 3. Energy, order and disorder, and organised systems -- 4. Outline of biological chemical principles : components, pathways and controls -- 5. First steps in evolution of prokaryotes : anaerobic chemotypes four to three billion years ago -- 6. The evolution of protoaerobic and aerobic prokaryote chemotypes (three to two billion years ago) -- 7. Unicellular eukaryotes chemotypes (about one and a half billion years ago?) -- 8. Multi-cellular eukaryote chemotypes (from one billion years ago) -- 9. The evolution of chemotypes with nerves and a brain (0.5 billion years ago to today) -- 10. Evolution due to mankind : a completely novel chemotype (less than one hundred thousand years ago) -- 11. Conclusion : the inevitable factors in evolution
  • Multiciliated cells of the respiratory epithelium are unique in that they generate hundreds of modified centrioles called basal bodies per cell. Each basal body anchors a motile cilium at the cell apical surface, and coordinated beating of motile cilia is vital for protecting from airway infection and for respiratory function. We used mice expressing GFP from the promoter of a ciliated cell-specific gene, FOXJ1, to obtain sorted populations of ciliating cells for transcriptional analysis. In addition to successfully identifying candidates found in other proteomics and genomics studies of motile and nonmotile cilia, approximately half of the significantly upregulated genes identified here have not yet been linked to cilia, and of those a third of are currently uncharacterized. We identified several genes associated with human diseases. These include FTO, which has been linked to human obesity, and DYX1C1, which is a candidate gene for developmental dyslexia. Interestingly, FTO localizes to cilia and Dyx1c1-GFP localizes to cilia and centrosomes, establishing novel links between cilia and two genetic diseases with poorly understood cellular and molecular etiology. Finally, we identified a number of transcription factors that are differentially expressed in ciliating mouse tracheal epithelial cells, including the proto-oncogene c-myb. We show that C-myb is expressed specifically in ciliating cells, and that this expression is temporally restricted to early in the differentiation process. These results suggest a role for the leukemogenic transcription factor C-myb in ciliated cell differentiation.
  • Circadian clocks 2013
    Molecular and cellular basis of circadian clocks -- Molecular components of the mammalian circadian clock / Ethan D. Buhr and Joseph S. Takahashi -- The epigenetic language of circadian clocks / Saurabh Sahar and Paolo Sassone-Corsi -- Peripheral circadian oscillators in mammals / Steven A. Brown and Abdelhalim Azzi -- Cellular mechanisms of circadian pacemaking: beyond transcriptional loops / John S. O'Neill, Elizabeth S. Maywood, and Michael H. Hastings -- The clock in the brain: neurons, glia, and networks in daily rhythms / Emily Slat, G. Mark Freeman Jr., and Erik D. Herzog -- Circadian control of physiology and behavior -- Circadian clocks and metabolism / Biliana Marcheva, Kathryn M. Ramsey, Clara B. Peek, Alison Affinati, Eleonore Maury, and Joseph Bass -- The circadian control of sleep / Simon P. Fisher, Russell G. Foster, and Stuart N. Peirson -- Daily regulation of hormone profiles / Andries Kalsbeek and Eric Fliers -- Circadian clocks and mood-related behaviors / Urs Albrecht -- Chronopharmacology and chronotherapy -- Molecular clocks in pharmacology / Erik S. Musiek and Garret A. FitzGerald -- Cancer chronotherapeutics: experimental, theoretical,and clinical aspects / E. Ortiz-Tudela, A. Mteyrek, A. Ballesta, P.F. Innominato, and F. Lévi -- Pharmacological modulators of the circadian clock as potential therapeutic drugs: focus on genotoxic/anticancer therapy / Marina P. Antoch and Roman V. Kondratov -- Light and the human circadian clock / Till Roenneberg, Thomas Kantermann, Myriam Juda, Ceéline Vetter, and Karla V. Allebrandt -- Systems biology of circadian clocks -- Mathematical modeling in chronobiology / G. Bordyugov, P.O. Westermark, A. Korenčič, S. Bernard, and H. Herzel -- Mammalian circadian clock: the roles of transcriptional repression and delay / Yoichi Minami, Koji L. Ode, and Hiroki R. Ueda -- Genome-wide analyses of circadian systems / Akhilesh B. Reddy -- Proteomic approaches in circadian biology / Maria S. Robles and Matthias Mann.
  • Circadian rhythms 2005
    Also available: Print – 2005
    Genetic approaches to circadian clocks -- Tracking circadian control of gene activity -- Molecular cycles : clock protein rhythms -- Anatomical representation of neural clocks -- Mosaic circadian systems -- Peripheral circadian clocks -- Cell and tissue culture system -- Intercellular signaling -- Photoresponsive clocks -- Sleeping flies -- Circadian biology of populations -- Circadian clocks affecting noncircadian biology.
  • Aging is a degenerative process accompanied by tissue deterioration, decline in function and increased susceptibility to disease. It is now understood to be a genetically and environmentally regulated process, rather than simply the result of wear and tear. We developed a systematic approach to identify combinatorial cis-regulatory motifs that drive age-dependent gene expression across different tissues and organisms, and identified the transcription factor NF-[kappa]B as a candidate regulator of aging. Using multiple independent models, we show a role for NF-[kappa]B in regulating transcriptional programs of aging. First, we found that aged mice subjected to NF-[kappa]B blockade for two weeks exhibit reversion of the tissue characteristics and global gene expression programs to those of young mice. Next, we detected deregulated transcriptional activity of NF-[kappa]B in Sirt6-deficient mice, which exhibit premature aging-like symptoms. We show that Sirt6 interacts with the NF-[kappa]B RelA subunit and deacetylates histone H3 lysine 9 (H3K9) at NF-[kappa]B target gene promoters. Computational genomics analyses revealed increased activity of NF-[kappa]B-driven gene expression programs in multiple Sirt6-deficient tissues in vivo. Moreover, haploinsufficiency of RelA rescues the early lethality and degenerative syndrome of Sirt6-deficient mice, suggesting that hyperactive NF-[kappa]B-dependent transcription in the absence of Sirt6 promotes premature aging-like syndromes. Finally, we performed a genome-scale survey of RelA and Sirt6 location on chromatin in mouse embryonic fibroblasts (MEFs) via chromatin immunoprecipiation (ChIP)-on-chip to understand to what extent Sirt6 and RelA act coordinately to regulate gene expression. These results indicate that RelA and Sirt6 co-occupy the promoters of a large population of genes at sites less than 500kb apart and/or require RelA to enable binding of Sirt6. Expression analysis of these shared targets reveals direct regulation of 301 promoters, including genes such as Shc1 (encoding p66), Cdkn2a (encoding p16), Wnt2 and Jmjd3, which have been separately implicated in the aging process. We propose that hyperactive NF-[kappa]B signaling contributes to premature and normal aging.
  • ch. 1. Cell Culture -- ch. 2. Preparation and Isolation of Cells -- ch. 3. Subcellular Fractionation and Isolation of Organelles -- ch. 4. Microscopy -- ch. 5. Characterization of Cellular Proteins -- ch. 6. Electrophoresis and Immunoblotting -- ch. 7. Protein Labeling and Immunoprecipitation -- ch. 8. Cell Cycle Analysis -- ch. 9. Cell Adhesion -- ch. 10. Extracellular Matrix -- ch. 11. In Vitro Reconstitution -- ch. 12. Cell Motility -- ch. 13. Organelle Motility -- ch. 14. Signal Transduction: Protein Phosphorylation -- ch. 15. Protein Trafficking -- ch. 16. Antibodies as Cell Biological Tools -- ch. 17. Macromolecular Interactions in Cells -- ch. 18. Cellular Aging and Death -- ch. 19. Whole Organism and Tissue Analysis -- ch. 20. Expression and Introduction of Macromolecules into Cells -- ch. 21. Fluorescent Protein Technology -- ch. 22. Cell Biology of Chromosomes and Nuclei -- ch. 23. Stem Cells -- ch. 24. Lipids -- ch. 25. Nanotechnology -- ch. 26. Viruses -- ch. 27. RNA-Based Methods in Cell Biology -- Appendix 1. Useful Information and Data -- Appendix 2. Laboratory Stock Solutions and Equipment -- Appendix 3. Commonly Used Techniques -- Appendix. Suppliers.
  • This well-established international series examines major areas of basic and clinical research within neuroscience, as well as emerging and promising subfields.This volume explores interdisciplinary research on decision making taking a neural and behavioural approach *Leading authors review the state-of-the-art in their field of investigation, and provide their views and perspectives for future research *Chapters are extensively referenced to provide readers with a comprehensive list of resources on the topics covered *All chapters include comprehensive background information and are written in a clear form that is also accessible to the non-specialist.
  • Understanding the general laws of an effective system for the transport of substances in cells is an important goal of systems and synthetic biology and will help us to answer why the transport subsystem of a cell is arranged as it is. In addition, the construction of models for optimizing transport systems is of considerable importance in the early stages in the development of a functioning protocell. The aim of this book is to describe the latest techniques for the calculation of the optimal parameters of the transport subsystem of a cell at its maximum efficiency.
  • Also available: Print – 2009
    Development of the dopamine systems in zebrafish / Jørn Schweitzer and Wolfgang Driever -- Dopamine systems in the forebrain / John W. Cave and Harriet Baker -- The role of Otx genes in progenitor domains of ventral midbrain / Antonio Simeone ... [et al.] -- Terminal differentiation of mesodiencephalic dopaminergic neurons : the role of Nurr1 and Pitx3 / Marten P. Smidt and J. Peter H. Burbach -- Foxa1 and Foxa2 transcription factors regulate differentiation of midbrain dopaminergic neurons / Siew-Lan Ang -- Transcriptional regulation of their survival : the engrailed homeobox genes / Horst H. Simon and Kambiz N. Alavian -- Neurotrophic support of midbrain dopaminergic neurons / Oliver von Bohlen und Halbach and Klaus Unsicker -- TGF in dopamine neuron development, maintenance, and neuroprotection / Eleni Roussa, Oliver von Bohlen und Halbach, and Kerstin Krieglstein -- Axon guidance in the dopamine system / Asheeta A. Prasad and R. Jeroen Pasterkamp -- Protocols for generating ES-cell-derived dopamine neurons / Sonja Kriks and Lorenz Studer -- Molecular and cellular determinants for generating ES-cell-derived dopamine neurons for cell therapy / -- Jan Pruszak and Ole Isacson.
  • Many organisms have evolved the ability to enter into and revive from a dormant state. They can survive for long periods in this state (often even months to years), yet can become responsive again within minutes or hours. This is often, but not necessarily, associated with desiccation. Preserving one 's body and reviving it in future generations is a dream of mankind. To date, however, we have failed to learn how cells, tissues or entire organisms can be made dormant or be effectively revived at ambient temperatures. In this book studies on organisms, ranging from aquatic cyanobacteria that produce akinetes to hibernating mammals, are presented, and reveal common but also divergent physiological and molecular pathways for surviving in a dormant form or for tolerating harsh environments. Attempting to learn the functions associated with dormancy and how they are regulated is one of the great future challenges. Its relevance to the preservation of cells and tissues is one of the key concerns of this book
  • Disturbance, survival, and succession : understanding ecological responses to the 1980 eruption of Mount St. Helens / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Geological and ecological settings of Mount St. Helens before May 18, 1980 / Frederick J. Swanson, Charles M. Crisafulli and David K. Yamaguchi -- Physical events, environments, and geological-ecological interactions at Mount St. Helens : March 1980-2004 / Frederick J. Swanson and Jon J. Major -- Plant responses in forests of the tephra-fall zone / Joseph A. Antos and Donald B. Zobel -- Plant succession on the Mount St. Helens debris-avalanche deposit / Virginia H. Dale ... [et al.] -- Geomorphic change and vegetation development on the Muddy River mudflow deposit / Peter M. Frenzen ... [et al.] -- Proximity, microsites, and biotic interactions during early succession / Roger del Moral, David M. Wood and Jonathan H. Titus -- Remote sensing of vegetation responses during the first 20 years following the 1980 eruption of Mount St. Helens : a spatially and temporally stratified analysis / Rick Lawrence -- Arthropods as pioneers in the regeneration of life on the pyroclastic-flow deposits of Mount St. Helens / John S. Edwards and Patrick M. Sugg -- Posteruption arthropod succession on the Mount St. Helens volcano : the ground-dwelling beetle fauna (Coleoptera) / Robert R. Parmenter ... [et al.] -- Causes and consequences of herbivory on prairie lupine (Lupinus lepidus) in early primary succession / John G. Bishop ... [et al.] -- Responses of fish to the 1980 eruption of Mount St. Helens / Peter A. Bisson ... [et al.] -- Amphibian responses to the 1980 eruption of Mount St. Helens / Charles M. Crisafulli ... [et al.] -- Small-mammal survival and colonization on the Mount St. Helens volcano : 1980-2002 / Charles M. Crisafulli, James A. MacMahon and Robert R. Parmenter -- Mycorrhizae and Mount St. Helens : story of a symbiosis / Michael F. Allen ... [et al.] -- Patterns of decomposition and nutrient cycling across a volcanic disturbance gradient : a case study using rodent carcasses / Robert R. Parmenter -- Lupine effects on soil development and function during early primary succession at Mount St. Helens / Jonathan J. Halvorson, Jeffrey L. Smith and Ann C. Kennedy -- Response and recovery of lakes / Clifford N. Dahm ... [et al.] -- Ecological perspectives on management of the Mount St. Helens landscape / Virginia H. Dale, Frederick J. Swanson and Charles M. Crisafulli -- Overview of ecological responses to the eruption of Mount St. Helens : 1980-2005 / Charles M. Crisafulli, Frederick J. Swanson and Virginia H. Dale.
  • Also available: Print – 2012
    Part I. Introduction -- Part II. Sound Detection by Aquatic Animals -- Part III. Sound Production by Aquatic Animals -- Part IV. Physiological Effects of Sounds -- Part V. Anthropogenic Sounds and Behavior -- Part VI. Population Effects -- Part VII. Anthropogenic Sound Sources and Their Measurement -- Part VIII. Science, Regulation and Sound Exposure Criteria -- Part IX. Monitoring, Management and Mitigation -- Part X. Workshops and Concluding Remarks.
  • Print Material
    pt. A. General medicine -- pt. B. Anatomy -- pt. C. Biology, genetics and biochemistry -- pt. D. Therapeutic substances.
  • Also available: Print – 2006
  • A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.
  • The primary nose and palate in evolution -- The primary nose and palate in human embryo development -- Parallels between evolution and development of the nose -- The seemingly simple formation of the secondary palate and nose in the human embryo -- The complex formation of the secondary palate and nose in evolution -- A theory of secondary palate formation -- Primary and secondary palates : primary and secondary nasal fossae -- Olfactory and respiratory nasal fossae -- Is the human ethmoid labyrinth a sinus? -- Understanding the anatomy of the human nose -- Formation of the paranasal air sinues -- The nose in midface development -- Reminder of the normal embryologic development of the human brain -- Phylogenetic origins of the visual and olfactory organs -- Lessons from midface malformations associated to holoprosencephaly -- The evo-devo scenario of nose and midface formation -- A help to teaching anatomy -- Medical hypothesis and perspectives -- Evolutionary and develomental (evo-devo) medicine.
  • Evolution : the molecular landscape 2009
    Cold Spring Harb Lab Press
  • In the first chapter, we argue that an individual organism ought not to be defined in terms of genetic homogeneity, but rather by the evolutionary criteria of the alignment of fitness interests, the export of fitness due to interdependence for survival and reproduction, and adaptive functional organization. We consider how these concepts apply to various putative individual organisms, review the costs and benefits of intraorganismal genetic heterogeneity, and demonstrate that high relatedness is neither necessary nor sufficient for individuality. In the second chapter, we model the benefits and costs of genetic mosaicism for a long-lived tree in coevolution with a short-lived pest. We demonstrate benefits of mosaicism for trees at both the individual and population levels when somatic mutation introduces new defenses. In the third chapter, we develop a game theoretic model of the decision to reject or fuse with a potential partner in a colonial ascidian, based on weighing costs and benefits of fusion. We find that once fused, the interactions between cell lineages are cooperative in the soma, but competitive in the germline.
  • I. Modelization of Evolution -- Rate of Adaptation of Large Populations / Feng Yu and Alison Etheridge, p. 3-27 -- A Phylogenetic Mixture Model for Heterotachy / Andrew Meade and Mark Pagel, p. 29-41 -- II. Concepts in Evolutionary Biology -- Accelerated Evolution of Genes of Recent Origin / Macarena Toll-Riera, Jose Castresana and M. Mar Albà, p. 45-59 -- Life-Cycle Features of Tumour Cells / Jekaterina Erenpreisa and Mark S. Cragg, 61-71 -- General Evolutionary Regularities of Organic and Social Life / Valeria I. Mikhalevich, p. 73-94 -- Old and New Concepts in EvoDevo / Margherita Raineri, p. 95-114 -- III. Knowledge -- Overturning the Prejudices about Hydra and Metazoan Evolution / Hiroshi Shimizu, p. 117-134 -- The Search for the Origin of Cnidarian Nematocysts in Dinoflagellates / Jung Shan Hwang, Satoshi Nagai, Shiho Hayakawa, Yasuharu Takaku and Takashi Gojobori, p. 135-152 -- IV. Applied Evolutionary Biology -- A Possible Relationship Between the Phylogenetic Branch Lengths and the Chaetognath rRNA Paralog Gene Functionalities: Ubiquitous, Tissue-Specific or Pseudogenes / Roxane-Marie Barthélémy, Michel Grino, Pierre Pontarotti, Jean-Paul Casanova and Eric Faure, p. 155-164 -- Mode and Tempo of matK : Gene Evolution and Phylogenetic Implications / Khidir W. Hilu and Michelle M. Barthet, p. 165-179 -- Phylogeography and Conservation of the Rare South African Fruit Chafer Ichnestoma stobbiai (Coleoptera: Scarabaeidae) / Ute Kryger and Clarke H. Scholtz, p. 181-196 -- Nothing in Medicine Makes Sense Except in the Light of Evolution: A Review / Bernard Swynghedauw, p. 197-207 -- An Overview of Evolutionary Biology Concepts for Functional Annotation: Advances and Challenges / Anthony Levasseur and Pierre Pontarotti, p. 209-215.
  • Also available: Print – 2012
  • Extremophiles. 1st ed. 2007
    Also available: Print – 2006
  • Pt. 1. Fluorescence spectroscopy: basics and advanced approaches. Basics of fluorescence spectroscopy in biosciences / M. Hof, V. Fidler and R. Hutterer -- Pulse and phase fluorometries: an objective comparison / B. Valeur -- Non-exponential fluorescence of electronically coupled donors contains distance information / S. Kalinin, M. Isaksson and L.B.-Å. Johansson -- Fluorescence nanotomography: recent progress, constraints and opportunities / O.J. Rolinski and D.J.S. Birch -- Solvent relaxation as a tool for probing micro-polarity and -fluidity / J. Sýkora, R. Hutterer and M. Hof -- Total internal reflection fluorescence microscopy: applications in biophysics / N.L. Thompson and J.K. Pero -- Single molecule spectroscopy: basics and applications / J. Enderlein -- Pt. 2. Application of fluorescence spectroscopy to biological membranes. Raft microdomains in model membranes as revealed by fluorescence quenching / G. Duportail -- The lateral structure of lipid membranes as seen by fluorescence microscopy / L.A. Bagatolli -- Pt. 3. Application of fluorescence spectroscopy to protein studies. Protein dynamics and protein folding dynamics revealed by time-resolved fluorescence / A. Saxena, J.B. Upgaonkar and G. Krishnamoorthy -- Time-resolved fluorescence and two-photon FCS investigation of the interaction of HIV-1 nucleocapsid protein with hairpin loop oligonucleotides / J. Azoulay ... [et al.] -- Pt. 4. Application of fluorescence spectroscopy to DNA and drug delivery. Fluorescence techniques in non-viral gene therapy / N. Adjimatera, A.P. Neal and I.S. Blagbrough -- Fluorescence applications in targeted drug delivery / K. Bryl and M. Langner -- Pt. 5. Fluorescence spectroscopy in cells: FCS and quantum dots. Fluorescence correlations spectroscopy in cell biology / B. Brock -- Fluorescence quantum dots: properties and applications / M.R. Warnement and S.J. Rosenthal -- Heat stress of cancer cells: fluorescence imaging of structural changes with quantum dots 605 and alexa 488.
  • Introduction: Systematics, evolution, and classification -- Systematics as problem solving -- The archetype -- Ernest Haeckel and systematische phylogenie -- The German development of morphology: from Ernest Haeckel to Willie Hanning -- Pattern Cladistics -- Homologues and homology -- Discovering homologues -- Homology and systematics -- Homology and transformation -- Character conflict -- The analyses of relationships -- Biogeograhical relationships, evolution, and classification.
  • Calcineurin is a Ca2+/calmodulin-dependent serine/threonine protein phosphatase conserved from yeast to mammals required for cell survival during environmental stress in yeast. It dephosphorylates several proteins located in different cellular compartments. Hph1 is a substrate of calcineurin that together with Hph2, its homolog, is also required for cellular adaptation to environmental stress. Hph1 and Hph2 are novel proteins of unknown function. Hph1 and Hph2 are tail-anchored integral ER-membrane proteins and have no identifiable homologs of in other organisms, except closely related yeast species. The goal of this work was to identify proteins that interact with Hph1 and Hph2 to help us identify their biological function. We show that Hph1 and Hph2 interact with the post-translational translocation machinery and are required for Vph1 stability, suggesting that they function in post-translational translocation at the ER. We have found several additional phenotypes for cells lacking HPH1 and HPH2 that overlap with the phenotypes observed for cells that have defects in vacuolar acidification. Hph1, but not Hph2, interacts with Vam6, a guanine-nucleotide-exchange factor, that regulates homotypic vacuolar fusion (through Ypt7) and TORC1 activation (through Gtr1). Interestingly, hph1[Delta] hph2[Delta] cells are resistant to rapamycin, further suggesting a role for these proteins in nutrient signaling. Structure-function analyses revealed that the coiled-coil motif is required for proper Hph1 localization and function, whereas the transmembrane domain is dispensable. This study has advanced our understanding of Hph1 and calcineurin function in regulating the cell's response to environmental stress and paves the way for a mechanistic understanding of Hph1 and Hph2 function in yeast.
  • Fungi. 2nd ed. 2001
    The fungi as a major group of organisms -- Fungal diversity -- Fungal cells and vegetative growth -- Spores, dormancy and dispersal -- Genetic variation and evolution -- Saprotrophs and ecosystems -- Parasites and mutualistic symbionts -- Fungi and biotechnology -- Glossary of common mycological terms -- Classification of fungi.
  • Remarkably, while G protein-coupled receptors (GPCRs) are highly prevalent in animals and yeast, very few candidate GPCRs have been identified in plants. In G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols, experts in the field describe techniques used in the study of small GTPases and related proteins. Beginning with a chapter on bioinformatics approaches for GPCR discovery, this detailed volume continues with chapters on heterotrimeric G protein subunits, Rab-GTPases, as well as lipid modifications, including myristoylation, acylation, and prenylation. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Practical and dependable, G Protein-Coupled Receptor Signaling in Plants: Methods and Protocols aims to aid further studies into the roles of small GTPases which will help elucidate numerous key processes in plants.
  • In humans, the hormones insulin and glucagon are the principal regulators of blood sugar homeostasis. In the fruit fly, Drosophila melanogaster, the regulation of circulating sugar levels is similarly controlled by insulin-like and glucagon-like factors. Insulin signaling in Drosophila has been studied intensively; by contrast, relatively little is known about the genetic regulation of Drosophila Adipokinetic hormone (Akh), the polypeptide with glucagon-like functions, and the corpora cardiaca (CC) cells that produce Akh. Here I describe the use of an enhancer trap screen that led to the identification of a novel regulator of CC function, the homeodomain transcription factor unplugged (unpg). Knocking down unpg in the CC cells results in decreased Akh transcript levels and reduced circulating glucose and trehalose. I also describe the identification of a number of enhancer traps that are capable of driving GFP expression in the CC cells, suggesting a role for the associated genes in CC cell function. As in human diabetes, insulin deficiency in the fruit fly elevates circulating glucose levels and impairs triglyceride regulation. Reduced insulin signaling in Drosophila also increases expression of the adipokine Akh, a phenotype reminiscent of the excessive glucagon signaling that accompanies human diabetes. Thus, it remains unclear if insulin deficiency or adipokine excess is the primary basis for diabetic phenotypes in flies lacking insulin-producing cells. Here I show that simultaneous targeted ablation of cells producing Drosophila insulin and adipokinetic hormone results in hypoglycemia. Mutation of the gene encoding the Akh receptor (Akhr) reduces circulating glucose levels in adult Drosophila lacking insulin, arguing that excessive Akh signaling is the basis for hyperglycemia in insulin-deficient flies. Simultaneous attenuation of insulin and Akh synthesis also produced hypoglycemic flies. Similar approaches revealed triglyceride imbalance from insulin deficiency requires Akh. Thus adipokines like Akh, not insulin, may be the principal hormonal regulators of glucose and lipid balance in some non-mammalian animal classes and states of insulin deficiency.
  • Honeybee / D. Schlipalius, P.R. Ebert, G.J. Hunt -- Bumblebee / L. Wilfert, P. Schmid-Hempel, J. Gadau -- The jewel wasp - Nasonia / J. Gadau ... [et al.] -- Silkworm / Y. Yasukochi, H. Fujii, M.R. Goldsmith -- Pea aphid / J.A. Brisson, G.K. Davis -- Mosquito / D.W. Severson -- Hessian fly / J.J. Stuart, M.-S. Chen, M.O. Harris -- Tick / A.J. Ullmann, J.J. Stuart, C.A. Hill.
  • Glucocorticoids (GCs) are stress hormones that are well-known for their potent and pleiotropic anti-inflammatory effects. In the injured CNS, their anti-inflammatory properties could be particularly beneficial due to the often detrimental effects of excessive inflammation in the brain. In more recent years, however, it has become clear that GCs do not always decrease inflammation and can even augment aspects of the immune response. The research presented in this doctoral dissertation describes the impact of this increased inflammatory response in the CNS using animal models of excitotoxicity and hypoxia/ischemia. Specifically, both exogenous GC treatments and the endogenously released GCs post-injury were found to increase immune cell activation (both in phenotype and in p65 nuclear translocation) in both rat and mouse models of excitotoxic hippocampal neuron death and in a mouse MCAO stroke model. These increased inflammatory responses are likely to be mediated by an unexpected GC-suppression of several anti-inflammatory cytokines including CX3CL1 and CD22 and failure of GCs to activate some of their normal anti-inflammatory targets like IkBa, IL-1ra, and MKP-1. Furthermore, these GC-augmented inflammatory responses are necessary for GCs to make more neurons die from either of these injuries. Taken together, this work demonstrates that cellular inflammation is not kept in check by GCs in the forebrain; instead, GCs worsen hippocampal and cortical neuron death, at least in part, by increasing the neurotoxicity of CNS inflammation.
  • Also available: Print – 2005
  • The golden mouse : a levels-of-organization perspective / Gary W. Barrett -- The golden mouse : taxonomy and natural history / George A. Feldhamer and Donald W. Linzey -- Population ecology of the golden mouse / Robert K. Rose -- Community ecology of the golden mouse / Cory C. Christopher and Guy N. Cameron -- Ecosystem ecology of the golden mouse / Steven W. Seagle -- Landscape ecology of the golden mouse / Jerry O. Wolff and Gary W. Barrett -- Relative abundance and conservation : is the golden mouse a rare species? / George A. Feldhamer and Anita T. Morzillo -- The golden mouse : a model of energetic efficiency / John D. Peles and Gary W. Barrett -- Nesting ecology of the golden mouse : an oikos engineer / Thomas M. Luhring and Gary W. Barrett -- Ectoparasites, bots, and vector-borne diseases associated with the golden mouse / Lance A. Durden -- Aesthetic landscapes of the golden mouse / Terry L. Barrett and Gary W. Barrett -- Future challenges and research opportunities : what do we really know? / Gary W. Barrett and George A. Feldhamer.
  • Print Material
  • Research and clinical application of vitamin D has increased dramatically over the past decade stimulated by novel health promotion discoveries and documentation. This book brings together key researchers with their views focusing on the health promotion role of vitamin D. Such information is vital to clinicians, users of vitamin D supplements of all ages and those interested in public policy. The authors document and define many of the key health related roles of vitamin D. Its traditional application in bone and muscle health as well as therapy of arthritis is expanded and clarified with new research. A better understanding of the effects of vitamin D inadequacy is modelled using problems ranging from infant growth retardation to chronic kidney and periodontal disease. Uniquely the vitamin?s role in resistance and treatment of infectious diseases is shown in examples ranging from HIV/AIDS to tuberculosis. Mechanistic understanding of vitamin D's actions is enhanced by looking into its effects on immune modulation and inflammation. Expansion of the role of sunlight in stimulating vitamin D production is discussed relative to the reduction in a variety of cancers. Clearly vitamin D is like a two edged sword with great benefits but also some risks. This book provides carefully defined examples of both situations.
  • Hearing and sound communication in amphibians : prologue and prognostication / Peter M. Narins and Albert S. Feng -- An integrated phylogeny of Amphibia / David Cannatella -- The behavioral ecology of anuran communication / Kentwood D. Wells and Joshua J. Schwartz -- Call production and neural basis of vocalization / Wolfgang Walkowiak -- Recognition and localization of acoustic signals / H. Carl Gerhardt and Mark A. Bee -- Pathways for sound transmission to the inner ear in amphibians / Matthew J. Mason -- Anatomy, physiology, and function of auditory end organs in the frog inner ear / Dwayne D. Simmons, Sebastiaan W.F. Meenderink and Pantelis N. Vassilakis -- Central auditory pathways in anuran amphibians : the anatomical basis of hearing and sound communication / Walter Wilczynski and Heike Endepols -- Function of the amphibian central auditory system / Gary J. Rose and David M. Gooler -- Plasticity in the auditory system across metamorphosis / Andrea Megela Simmons and Seth S. Horowitz -- Sound processing in real-world environments / Albert S. Feng and Johannes Schul.
  • Approaches to the analysis of faunal change during the East African Pliocene / A.K. Behrensmeyer, R. Bobe, and Z. Alemseged -- Environmental hypotheses of Pliocene human evolution / R. Potts -- African Pliocene and Pleistocene cercopithecid evolution and global climatic change / S.R. Frost -- Patterns of change in the Plio-Pleistocene carnivorans of eastern Africa : implications for hominin evolution / M.E. Lewis and L. Werdelin-- Stratigraphic variation in Suidae from the Shungura Formation and some coeval deposits / H.B.S. Cooke -- Patterns of abundance and diversity in late Cenozoic bovids from the Turkana and Hadar Basins, Kenya and Ethiopia / R. Bobe, A.K. Behrensmeyer, G.G. Eck, and J.M. Harris -- Comparability of fossil data and its significance for the interpretation of hominin environments : a case study in the lower Omo Valley, Ethiopia / Z. Alemseged, R. Bobe, and D. Geraads -- The effects of collection strategy and effort on faunal recovery : a case study of the American and French collections from the Shungura Formation, Ethiopia / G.G. Eck -- Serengeti micromammals and their implications for Olduvai paleoenvironments / D.N. Reed -- Taphonomy and paleoecological context of the upper Laetolil Beds (localities 8 and 9), Laetoli in northern Tanzania / C. Musiba, C. Magori, M. Stoller, T. Stein, S. Branting, M. Vogt, R. Tuttle, B. Hallgrímsson, S. Killindo, F. Mizambwa, F. Ndunguru, and A. Mabulla -- The paleoecology of the upper Laetolil Beds at Laetoli : a reconsideration of the large mammal evidence / D.F. Su and T. Harrison -- Fauna, taphonomy, and ecology of the Plio-Pleistocene Chiwondo Beds, northern Malawi / O. Sandrock, O. Kullmer, F. Schrenk, Y.M. Juwayeyi, and T.G. Bromage-- Investigating faunal evidence for hominin paleoecology in East Africa / A.K. Behrensmeyer, Z. Alemseged, and R. Bobe.
  • The epidermal growth factor receptor (EGFR) is essential to multiple physiologic and neoplastic processes via signaling by its tyrosine kinase domain and subsequent activation of transcription factors. We identified a novel splice variant of the EGFR called mini-LEEK (mLEEK) which represents a deletion of exons 2-22 but maintains the open reading frame and generates a novel glycine codon at the junction. This variant deletes the extracytoplasmic domain, transmembrane region, and most of the tyrosine kinase domain of the EGFR. mLEEK is localized to the nucleus in most cells and since it contains a previously characterized strong transactivation domain, we hypothesized that mLEEK functions to regulate transcription. Microarray studies revealed upregulation of several molecular chaperone proteins, including GRP78 (also known as BiP) and GRP94, in response to mLEEK expression. Overexpression of mLEEK resulted in increased transcription from GRP78 and GRP94 luciferase reporter plasmids as well as an increase in endogenous GRP78 and GRP94 protein levels, suggesting a direct effect on transcription. Furthermore, mLEEK utilizes the cis-regulatory ER stress response element (ERSE) found in both the GRP78 and GRP94 promoters to activate transcription as mutation of the ERSE elements in the GRP78 promoter abolishes the activation of transcription by mLEEK. Chromatin immunoprecipitation experiments demonstrate that mLEEK physically interacts in a complex with the ERSE-containing region of the GRP78 promoter. Additionally, mLEEK co-precipitates with ATF6, a transcription factor known to be part of the ERSE-mediated activation of chaperones. Molecular chaperone transcription is induced as a downstream effector of the unfolded protein response (UPR). The UPR is a mechanism that increases the cellular capacity for protein folding. Cellular demands for protein folding increase upon physiological conditions that create endoplasmic reticulum (ER) stress. Interestingly, mLEEK specifically upregulates molecular chaperones required for the UPR and does not activate other arms of the UPR. Splicing of XBP1 precursor mRNA, which is uniquely triggered upon ER stress, was reduced in cells overexpressing mLEEK. Another molecular readout for UPR induction is the activation of CHOP transcription. Cells overexpressing mLEEK demonstrated reduced activation of CHOP transcription in the presence of ER stress inducing agents. Moreover, knockdown of mLEEK results in enhanced sensitivity to ER stress. Collectively, these data suggest that expression of mLEEK and the subsequent upregulation molecular chaperones primes cells to accommodate the increased need for protein folding upon ER stress and prevents induction of the UPR. mLEEK is also essential for cell viability, as mLEEK knockdown lead to reduced viability and increased activation of caspases. We found that mLEEK is present at the RNA and protein level in a high percentage of tumors relative to normal tissue. Preliminary data suggest that mLEEK expression does not lead to transformation of NIH3T3 cells. The potential contribution of mLEEK to tumorigenesis will be revisited in the future using knockdown strategies that were subsequently developed. Other preliminary data have shown that mLEEK is secreted into the media and taken up by neighboring cells, leading to increased GRP94 transcription in recipient cells. Collectively, our work describes the discovery and characterization of a novel EGFR variant. These findings reveal an unexpected function for an EGFR variant and represent a new mechanism for the upregulation of molecular chaperones required for the UPR that could be exploited for therapeutic purposes. Our findings also suggest a potential role for mLEEK in cancer and a novel method of cell communication mediated by a secreted protein. These possibilities await future studies.
  • Evolution of resistance genes in plants / Shunyuan Xiao, Wenming Wang, Xiaohua Yang -- The path less explored: innate immune reactions in Cnidarians / Thomas C. G. Bosch -- Bug versus bug : humoral immune responses in Drosophila melanogaster / Deniz Ertürk-Hasdemir ... [et al.] -- Cellular immune responses in Drosophila melanogaster / Adrienne Ivory, Katherine Randle, Louisa Wu -- Immune reactions in the vertebrates' closest relatives, the urochordates / Konstantin Khalturin, Ulrich Kürn, Thomas C. G. Bosch -- Innate immune system of the zebrafish, Danio rerio / Con Sullivan, Carol H. Kim -- Toll-like receptors in the mammalian innate immune system / Andrei E. Medvedev, Stefanie N. Vogel -- NLRs : a cytosolic armory of microbial sensors linked to human diseases / Mathias Chamaillard -- Antimicrobial peptides as first-line effector molecules of the human innate immune system / Regine Gläser, Jürgen Harder, Jens-Michael Schröder -- The complement system in innate immunity / K. R. Mayilyan ... [et al.].
  • Also available: Print – 2010
    Identification of cholinergic synaptic transmission in the insect nervous system / Steeve Hervé Thany, Hélène Tricoire-Leignel, and Bruno Lapied -- The evolution of pentameric ligand-gated ion channels / Joseph A. Dent -- Diversity of insect nicotinic acetylcholine receptor subunits / Andrew K. Jones and David B. Sattelle -- Identification of critical elements determining toxins and insecticide affinity, ligand binding domains, and channel properties / Hélène Tricoire-Leignel and Steeve Hervé Thany -- Electrophysiological studies and pharmacological properties of insect native nicotinic acetylcholine receptors / Steeve Hervé Thany -- Characterisation of insect nicotinic acetylcholine receptors by heterologous expression / Neil S. Millar and Stuart J. Lansdell -- Neonicotinoid insecticides : historical evolution and resistance mechanisms / Steeve Hervé Thany -- Ecotoxicity of neonicotinoid insecticides to bees / Axel Decourtye and James Devillers -- State of the art on insect nicotinic acetylcholine receptor function in learning and memory / Monique Gauthier.
  • The work presented in this dissertation primarily focuses on decision-related activity in the lateral intraparietal area (LIP) and, secondarily, the dorsolateral prefrontal cortex (DLPFC). In Chapter 1 we review the previous independent investigations indicating that these areas are separately modulated by sensory information, value information and choice appropriate to represent decisions. We argue that when both sensory and value information must be simultaneously integrated to make choices, it is unknown, if, how and when these areas integrate these factors. We present a behavioral paradigm in which animal subjects must combine sensory and value information, on a trial-to-trial basis, to make optimal choices. This paradigm is based on a well-known motion discrimination task; however, in our task the magnitude of the reward associated with each option varies from trial to trial. On some trials both options are worth equally large or small rewards. On other trials one option's reward is greater than that of the other. In Chapter 2, we demonstrate that in the unequal reward conditions subjects' choices are consistently biased towards the greater magnitude option. Additionally, we will show that this bias is independent of the motion stimulus strength and its magnitude is nearly optimal. In Chapter 3, we observe that single neurons in cortical area LIP consistently, simultaneously and dynamically represent both sensory and value information. We will argue that this representation supports an integrator model of decision making, in which sensory information is accumulated until the decision is resolved by a threshold crossing. Our results support an interpretation of this model in which value information adjusts the likelihood of a threshold crossing by iv raising or lowering the accumulator's initial state. In Chapter 4, we present a preliminary comparison between LIP and DLPFC activity, under identical conditions, suggesting they play fundamentally different roles in decision making. In Chapter 5, we discuss future lines of research.
  • High-throughput genomics has been increasingly generating the massive amount of genome-wide data. With proper modeling methodologies, we can expect to archive a more comprehensive understanding of the regulatory mechanisms of biological systems. This work presents integrative approaches for the modeling and analysis of gene regulatory systems. In mammals, gene expression regulation is combinatorial in nature, with diverse roles of regulators on target genes. Microarrays (such as Exon Arrays) and RNA-Seq can be used to quantify the whole spectrum of RNA transcripts. ChIP-Seq is being used for the identification of transcription factor (TF) binding sites and histone modification marks. RNA interference (RNAi), coupled with gene expression profiles, allow perturbations of gene regulatory systems. Our approaches extract useful information from those genome-wide measurements for effectively modeling the logic of gene expression regulation. We present a predictive model for the prediction of gene expression from ChIP-Seq signals, based on quantitative modeling of regulator-gene association strength, principal component analysis, and regression-based model selection. We demonstrate the combinatorial regulation of TFs, and their power for explaining genome-wide gene expression variation. We also illustrate the roles of covalent histone modification marks on predicting gene expression and their regulation by TFs. We present a dynamical model of gene expression profiling, and derive the perturbed behaviors of the ordinary differential equation (ODE) system. Based on that, we present a regularized multivariate regression method for inferring the gene regulatory network of a stable cell type. We model the sparsity and stability of the network by a regularization approach. We applied the approaches to both a simulation data set and the RNAi perturbation data in mouse embryonic stem cells.
  • The study of biological rhythms -- General features of rhythms : terminology and characteristics -- Physical and biological time -- Photoperiodism -- Biological oscillators and timers : models and mechanisms -- Tidal and lunar rhythms -- Sexuality and reproduction -- Natural resources and agriculture -- Veterinary medicine -- Society -- Clinical medicine -- Autorhythmometry -- Chronobiometry : analyzing for rhythms.
  • ch. 1. Introduction -- ch. 2. Fundamentals of Light and Matter -- ch. 3. Basics of Biology -- ch. 4. Fundamentals of Light-Matter Interactions -- ch. 5. Principles of Lasers, Current Laser Technology, and Nonlinear -- ch. 6. Photobiology -- ch. 7. Bioimaging: Principles and Techniques -- ch. 8. Bioimaging: Applications -- ch. 9. Biosensors -- ch. 10. Microarray Technology for Genomics and Proteomics -- ch. 11. Flow Cytometry -- ch. 12. Light-Activated Therapy: Photodynamic Therapy -- ch. 13. Tissue Engineering with Light -- ch. 14. Laser Tweezers and Laser Scissors -- ch. 15. Nanotechnology for Biophotonics: Bionanophotonics -- ch. 16. Biomaterials for Photonics.
  • Also available: Print – 2008
  • Microscopy -- Microtome -- pH and Buffers -- Spectrophotometer -- Centrifugation -- Radiation Biology -- Chromatography -- Separation Technology -- Histochemical Techniques -- Cytogenetics -- Biomolecules -- Enzymology -- Membranes -- Photosynthesis and Respiration -- Microbiology -- Soil Biology -- Virology -- Immunochemical Methods -- Genetic Engineering -- Molecular Biology -- Biosensors -- Enzyme Immobilization -- Plant Tissue Culture -- Animal Cell Science and Technology -- Bioprocess Engineering -- Environmental Biology -- Bioinformatics
  • Introduction: Bateson the precursor / Jesper Hoffmeyer -- Angels fear revisited: Gregory Bateson's cybernetic theory of mind applied to religion-science debates / Mary Catherine Bateson -- From thing to relation. On Bateson's bioanthropology / Jesper Hoffmeyer -- What connects the map to the territory? / Tyrone Cashman -- The pattern which connects pleroma to creatura: the autocell bridge from physics to life / Terrence Deacon and Jeremy Sherman -- Bateson's method: double description. What is it? How does it work? What do we learn? / Julie Hui, Tyrone Cashman, and Terrence Deacon -- Gregory Bateson's relevance to current molecular biology / Luis Emilio Bruni -- Process ecology: creatura at large in an open universe / Robert E. Ulanowicz -- Connections in action - bridging implicit and explicit domains / Teresa S.S. Shilhab and Christian Gerlach -- Bateson: biology with meaning / Brian Goodwin -- Gregory Bateson's "uncovery" of ecological aesthetics / Peter Harries-Jones -- Collapsing the wave function of meaning: the epistemological matrix of talk-in-interaction / Donald Favareau -- Re-enchanting evolution: transcending fundamentalisms through a mythopoetic epistemology / Gregory Mengel -- Bateson and Peirce on the pattern that connects and the sacred / Søren Brier -- Bateson, Peirce and the sign of the sacred / Deborah Eicher-Catt.
  • Lemur origins, history of ecological studies on lemurs, and the ecology of the recently extinct (subfossil) lemurs -- Origin of the Malagasy strepsirhine primates / Ian Tattersall -- Notes on the history of ecological studies of Malagasy lemurs / Alison Jolly and R.W. Sussman -- Ecology and extinction of Madagascar's subfossil lemurs / Laurie R. Godfrey, William L. Jungers, and Gary T. Schwartz -- The evolution of lemur traits, basic and unusual patterns -- Impact of ecology on the teeth of extant lemurs : a review of dental adaptations, function, and life history / Frank P. Cuozzo and Nayuta Yamashita -- Big is beautiful : fat storage and hibernation as a strategy to cope with marked seasonality in the fat-tailed dwarf lemur (Cheirogaleus medius) / Joanna Fietz and K.H. Dausmann -- Polyspecific associations of crowned lemurs and Sanford's lemurs in Madagascar / Benjamin Z. Freed -- Cathemerality in lemurs / Deborah J. Curtis -- Adaptations in the aye-aye : a review / Eleanor J. Sterling and Erin E. McCreless -- Connecting ecology and adaptation : summaries and new studies -- Evolutionary divergence in the brown lemur species complex / Steig E. Johnson -- Ecological diversity and seasonal adaptations of mouse lemurs (Microcebus spp.) / Ute Radespiel -- Social pair-bonding and resource defense in wild red-bellied lemurs (Eulemur rubriventer) / Deborah J. Overdorff and Stacey R. Tecot -- Lemur catta ecology : what we know and what we need to know / Lisa Gould -- Impact of seasonality and reproduction on social structure, ranging patterns, and fission-fusion social organization in red ruffed lemurs / Natalie Vasey -- Ecologically enigmatic lemurs : the sifakas of the eastern forests (Propithecus candidus, P. diadema, P. edwardsi, P. perrieri, P. tattersalli) / Mitchell T. Irwin -- Behavioral and ecological adaptations in two small folivorous lemurs with different social organization : Avahi and Lepilemur / Urs Thalmann -- The feeding ecology and related adaptations of Indri indri / Joyce A. Powzyk and Christopher B. Mowry -- Behavior and ecology of gentle lemurs (genus Hapalemur) / Chia L. Tan -- Lemur adaptations to a changing environment, natural and anthropogenic stress -- Considering climate change effects in lemur ecology and conservation / Patricia C. Wright -- Diet composition, foraging, and feeding behavior in relation to habitat disturbance : implications for the adaptability of ruffed lemurs (Varecia variegata editorium) in Manombo Forest, Madagascar / Jonah Ratsimbazafy -- Overview on the health and disease ecology of wild lemurs : conservation implications / Randall E. Junge and Michelle L. Sauther
  • Life as we know it 2006
  • Earliest evidence of Deltatheroida (Mammalia: Metatheria) from the early Cretaceous of North America / Brian M. Davis, Richard L. Cifelli and Zofia Kielan-Jaworowska -- Evolution of hind limb proportions in kangaroos (Marsupialia: Macropodoidea) / Benjamin P. Kear ... [et al.] -- Changing views in paleontology : the story of a giant (Megatherium, Xenarthra) / Christine Argot -- Evolutionary morphology of the Tenrecoidea (Mammalia) forelimb skeleton / Justine A. Salton and Eric J. Sargis -- Postcranial morphology of Apheliscus and Haplomylus (Condylarthra, Apheliscidae) : evidence for a Paleocene Holarctic origin of Macroscelidea / Tonya A. Penkrot ... [et al.] -- Postcranial skeleton of the Upper Paleocene (Itaboraian) "Condylarthra" (Mammalia) of the Itaboraí Basin, Brazil / Lilian P. Berqvist -- Postcranial osteology of mammals from Salla, Bolivia (late Oligocene) : form, function, and phylogenetic implications / Bruce J. Shockey and Frederico Anaya -- Evolution of the proximal third phalanx in Oligocene-Miocene equids, and the utility of phalangeal indices in phylogeny reconstruction / Jay A. O'Sullivan -- Adaptive zones and the pinniped ankle : a three-dimensional quantitative analysis of carnivoran tarsal evolution / P. David Polly -- The biogeographic origins of Primates and Euprimates : east, west, north, or south of Eden? / Mary T. Silcox -- Evaluating the mitten-gliding hypothesis for Paromomyidae and Micromomyidae (Mammalia, "Plesiadapiformes") using comparative functional morphology of new Paleogene skeletons / Douglas M. Boyer and Jonathan I. Bloch -- Morphological diversity in the skulls of large adapines (Primates, Adapiformes) and its systematic implications / Marc Godinot and Sébastien Couette -- Primate tibiae from the middle Eocene Shanghuang fissure-fillings of eastern China / Marian Dagosto ... [et al.] -- Rooneyia, postorbital closure, and the beginnings of the age of Anthropoidea / Alfred L. Rosenberger, Russell Hogg and Sai Man Wong -- Epitensoric position of the chorda tympani in Anthropoidea : a new synapomorphic character, with remarks on the fissura Glaseri in Primates / Wolfgang Maier -- Evolutionary morphology of the guenon postcranium and its taxonomic implications / Eric J. Sargis, Carl J. Terranova and Daniel L. Gebo -- Analysis of selected hominoid joint surfaces using laser scanning and geometric morphometrics : a preliminary report / William E.H. Harcourt-Smith ... [et al.] -- Comparative primate bone microstructure: records of life history, function, and phylogeny / Johanna Warshaw.
  • Also available: Print – 2006

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