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Anti-Infective Agents

  • 1. Historical introduction -- 2. Modes of action -- 3. The problem of resistance -- 4. Pharmacodynamics of anti-infective agents: target delineation and susceptibility breakpoint selection -- 5. Antimicrobial agents and the kidneys -- 6. Drug interactions involving anti-infective agents -- 7. Antibiotics and the immune system -- 8. General principles of antimicrobial chemotherapy -- 9. Laboratory control of antimicrobial therapy -- 10. Principles of chemop rophylaxis -- 11. Antibiotic policies -- 12. Aminoglycosides and aminocyclitols -- 13. β-Lactam antibiotics : cephalosporins -- 14. β-Lactam antibiotics: penicillins -- 15. Other β-lactam antibiotics -- 16. Chloramphenicol and thiamphenicol -- 17. Diaminopyrimidines -- 18. Fosfomycin and fosmidomycin -- 19. Fusidanes -- 20. Glycopeptides -- 21. Lincosamides -- 22. Macrolides -- 23. Mupirocin -- 24. Nitroimidazoles -- 25. Oxazolidinones -- 26. Quinolones -- 27. Rifamycins -- 28. Streptogramins -- 29. Sulfonamides -- 30. Tetracyclines -- 31. Miscellaneous antibacterial agents -- 32. Antifungal agents -- 33. Antimycobacterial agents -- 34. Anthelmintics -- 35. Antiprotozoal agents -- 36. Antiretroviral agents -- 37. Other antiviral agents -- 38. Sepsis -- 39. Abdominal and other surgical infections -- 40. Infections associated with neutropenia and transplantation -- 41. Infections in intensive care patients -- 42. Infections associated with implanted medical devices -- 43. Antiretroviral therapy for HIV -- 44. Infections of the upper respiratory tract -- 45. Infections of the lower respiratory tract -- 46. Endocarditis -- 47. Infections of the gastrointestinal tract -- 48. Hepatitis -- 49. Skin and soft-tissue infections -- 50. Bacterial infections of the central nervous system -- 51. Viral infections of the central nervous system -- 52. Bone and joint infections -- 53. Infections of the eye -- 54. Urinary tract infections -- 55. Infections in pregnancy -- 56. Sexually transmitted diseases -- 57. Leprosy -- 58. Tuberculosis and other mycobacterial infections -- 59. Superficial and mucocutaneous mycoses -- 60. Systemic fungal infections -- 61. Zoonoses -- 62. Malaria -- 63. Other protozoal infections -- 64. Helminthic infections.
  • Introduction to antibiotic resistance/ Richard Bax, David Griffin -- The origins of antibiotic resistance/ Gerard D. Wright -- Surveillance programmes and antibiotic resistance: worldwide and regional monitoring of antibiotic resistance trends/ Stephen Hawser -- Current and future challenges in the development of antimicrobial agents/ Robert P. Rennie -- The role of the outer membrane of gram-negative bacteria in antibiotic resistance: Ajax' shield or Achilles' heel?/ Malcolm G.P. Page -- Prevention of drug resistance by combined drug treatment of tuberculosis/ Denis A. Mitchison -- Nonmultiplying bacteria are profoundly tolerant to antibiotics / Yanmin Hu, Anthony Coates -- Persister cells: molecular mechanisms related to antibiotic tolerance / Kim Lewis -- Antimicrobial textiles / J. Vaun McArthur, R.C. Tuckfield, C. Baker-Austin -- Efflux: how bacteria use pumps to control their microenvironment / E. David G. McIntosh -- Antibiotics in phase II and III clinical trials / Anthony R.M. Coates, Gerry Halls.
  • Part 1. Considerations with antibiotic therapy -- Part 2. Antibacterial drugs -- Part 3. Antimycobacterial drugs -- Part 4. Antifungal drugs -- Part 5. Antiviral drugs -- Part 6. Antiparasitic Drugs -- Appendix 1. Selected normal human flora -- Appendix 2. Spectrum of activity -- Appendix 3. Empiric regimens for common infections -- Index.
    Limited to 6 simultaneous users
    Includes information on antimicrobial therapy and alternative therapy when the drug of choice cannot be given. The resource delivers information via review articles, capsule summaries, mini-reviews, and a guided PubMed search to pick up post-publication research.
  • Since penicillin and salvarsan were discovered, a number of new drugs to combat infectious diseases have been developed, but at the same time, the number of multi-resistant microorganism strains is increasing. Thus, the design of new and effective antibacterial, antiviral and antifungal agents will be a major challenge in the next years. This book reviews the current state-of-the-art in antimicrobial research and discusses new strategies for the design and discovery of novel therapies. Topics covered include the use of genetic engineering, genome mining, manipulation of gene clusters, X-ray and neutron scattering as well as the antimicrobial effects of essential oils, antimicrobial agents of plant origin, beta-lactam antibiotics, antimicrobial peptides, and cell-wall-affecting antifungal antibiotics.
  • This report examines, for the first time, the current status of surveillance and information on antimicrobial resistance (AMR) at country level worldwide, with particularly attention to antibacterial resistance.
  • Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
  • Microbial drug resistance: a historical perspective / William C. Summers -- Ecology of antibiotic resistance genes / Abigail A. Salyers, Nadja Shoemaker, and David Schlesinger -- Global response systems that confer resistance / Paul F. Miller and Philip N. Rather -- Multidrug efflux pumps: structure, mechanism, and inhibition / Olga Lomovskaya ... [et al.] -- Mechanisms of aminoglycoside antibiotic resistance / Gerard D. Wright -- Resistance to [beta]-lactam antibiotics mediated by [beta]-lactamases : structure, mechanism, and evolution / Jooyoung Cha, Lakshmi P. Kotra, and Shahriar Mobashery -- Target modification as a mechanism of antimicrobial resistance / David C. Hooper -- Antibiotic permeability / Harry Taber -- Genetic methods for detecting bacterial resistance genes / Ad C. Fluit -- Evolution and epidemiology of antibiotic-resistant pneumococci / Christopher Gerard Dowson and Krzysztof Trzcinski -- Antimicrobial resistance in the enterococcus / George M. Eliopoulos -- Methicillin resistance in staphylococcus aureus / Keeta S. Gilmore, Michael S. Gilmore, and Daniel F. Sahm -- Mechanism of drug resistance in mycobacterium tuberculosis / Alex S. Pym and Stewart T. Cole -- Antibiotic resistance in enterobacteria / Nafsika H. Georgopapadakou -- Resistance as a worldwide problem / Paul Shears -- Public health responses to antimicrobial resistance in outpatient and inpatient settings / Cindy R. Friedman and Arjun Srinivasan -- Antibacterial drug discovery in the 21st century / Steven J. Projan.
  • Front Cover; About the Editor; Contents; Acknowledgment and How to Cite; List of Contributors; Introduction; Chapter 1: Potential Novel Therapeutic Strategies in Cystic Fibrosis: Antimicrobial and Anti-Biofilm Activity of Natural and Designed [alpha]-Helical Peptides Against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia; Chapter 2: Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase. 1. Potential novel therapeutic strategies in cystic fibrosis : antimicrobial and anti-biofilm activity of natural and designed A-helical peptides against staphylococcus aureus, pseudomonas aeruginosa, and stenotrophomonas maltophilia / Arianna Pompilio, Valentina Crocetta, Marco Scocchi, Stefano Pomponio, Valentina Di Vincenzo, Mario Mardirossian, Giovanni Gherardi, Ersilia Fiscarelli, Giordano Dicuonzo, Renato Gennaro, and Giovanni Di Bonaventura -- 2. Dispersal of biofilms by Secreted, Matrix Degrading, Bacterial DNase / Reindert Nijland, Michael J. Hall, and J. Grant Burgess -- 3. The RNA processing enzyme polynucleotide phosphorylase negatively controls biofilm formation by repressing poly-n-acetylglucosamine (PNAG) production in escherichia coli C / Thomas Carzaniga, Davide Antoniani, Gianni Deh, ̣Federica Briani, and Paolo Landini -- 4. Comparative proteomic analysis of streptococcus suis biofilms and planktonic cells that identified biofilm infection-related immunogenic proteins / Yang Wang, Li Yi, Zongfu Wu, Jing Shao, Guangjin Liu, Hongjie Fan, Wei Zhang, and Chengping Lu -- 5. Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of bacillus licheniformis / S.M. Abu Sayem, Emiliano Manzo, Letizia Ciavatta, Annabella Tramice, Angela Cordone, Anna Zanfardino, Maurilio De Felice, and Mario Varcamonti -- 6. Osteopontin reduces biofilm formation in a multi-species model of dental biofilm / Sebastian Schlafer, Merete K. Raarup, Peter L. Wejse, Bente Nyvad, Brigitte M. Std̃ler, Duncan S. Sutherland, Henrik Birkedal, and Rikke L. Meyer -- 7. Impairment of the bacterial biofilm stability by triclosan / Helen V. Lubarsky, Sabine U. Gerbersdorf, Cďric Hubas, Sebastian Behrens, Francesco Ricciardi, and David M. Paterson -- 8. Antimicrobial pressure of ciprofloxacin and gentamicin on biofilm development by an endoscope-isolated pseudomonas aeruginosa / Idalina Machado, Joana Graȧ, Hľder Lopes, Susana Lopes, and Maria O. Pereira -- 9. Inhibition of staphylococcus epidermidis biofilm formation by traditional Thai herbal recipes used for wound treatment / S. Chusri, K. Sompetch, S. Mukdee, S. Jansrisewangwong, T. Srichai, K. Maneenoon, S. Limsuwan, and S.P. Voravuthikunchai -- 10. In vitro assessment of shiitake mushroom (lentinula edodes) extract for its antigingivitis activity / Lena Ciric, Anna Tymon, Egija Zaura, Peter Lingstrm̲, Monica Stauder, Adele Papetti, Caterina Signoretto, Jonathan Pratten, Michael Wilson, and David Spratt -- 11. Antimicrobial, antimycobacterial and antibiofilm properties of couroupita guianensis aubl. fruit extract / Naif Abdullah Al-Dhabi, Chandrasekar Balachandran, Michael Karunai Raj, Veeramuthu Duraipandiyan, Chinnasamy Muthukumar, Savarimuthu Ignacimuthu, Inshad Ali Khan, and Vikrant Singh Rajput -- 12. Fur is a repressor of biofilm formation in yersinia pestis / Fengjun Sun, He Gao, Yiquan Zhang, Li Wang, Nan Fang, Yafang Tan, Zhaobiao Guo, Peiyuan Xia, Dongsheng Zhou, and Ruifu Yang -- 13. Hsp90 governs dispersion and drug resistance of fungal biofilms / Nicole Robbins, Priya Uppuluri, Jeniel Nett, Ranjith Rajendran, Gordon Ramage, Jose L. Lopez-Ribot, David Andes, and Leah E. Cowen -- 14. Candida biofilms and the host : models and new concepts for eradication / Hľn̈e Tournu and Patrick Van Dijck -- 15. Innovative strategies to overcome biofilm resistance / Aleksandra Taraszkiewicz, Grzegorz Fila, Mariusz Grinholc, and Joanna Nakonieczna.
  • "Cancer-causing viruses, also called oncoviruses, play a key role in the development of certain cancers. They contribute to genetic changes that disrupt the cell cycle machinery, interfering with functions such as cell growth. Cancer-Causing Viruses and Their Inhibitors presents a plethora of research from internationally reputed contributors who discuss different types of oncoviruses, their mechanisms of invasion and growth, and their life cycles. The book begins with an overview of the oncoviruses discovered to date and includes a brief description of their structures, genotypes, replication, and mechanisms of infection leading to cancers. It then explores several of these viruses in detail, including: Human T-cell leukemia virus type 1 (HTLV-1), Hepatitis C virus (HCV), Epstein-Barr virus (EBV), Human papilloma virus (HPV), Human herpes virus 8 (HHV-8)/Kaposi's sarcoma-associated herpes virus (KSHV), Human immunodeficiency virus (HIV/AIDS), Oncolytic viruses. This book is an essential reference for those working in virology, oncology, and biotechnology. The discoveries presented will enable researchers and clinicians to optimize both historical and current approaches to anti-viral therapies"--Provided by publisher.
  • Classification of the Antibiotics -- Antibiotics Marketed in the EU -- Principles of Antibiotic Therapy -- The Most Common Errors in Antibiotic Therapy -- Important Infections and Their Microbiological Diagnosis -- Cooperation with Microbiologists -- Resistance of Major Clinical Pathogens -- The Most Frequent Pathogens- Choice of Antibiotics -- Antibiotics, Antimycotics: Spectrum- Dosage- Adverse Effects- Costs -- Antibiotic Therapy of the Principal Infections in Children and Adults -- Treatment of the Most Frequent Types of Bacterial Endocarditis -- Minimal Duration of Treatment for Bacterial Infections -- Failure of Antibiotic Therapy -- Fever of Unknown Origin: Differential Diagnosis -- Dosage of Antibiotics in Impaired Renal Function -- Antibiotic Therapy in Haemodialysis, Peritoneal Dialysis, and Continuous Haemofiltration -- Antibiotic Therapy During Pregnancy and Lactation -- Antibiotics in Liver Diseases -- Diffusion of Antibiotics in Cerebrospinal Fluid and in Cerebral Abscesses -- Local Antibiotics -- Prophylactic Antibiotic Therapy -- Physical Incompatibility of Antibiotics and Antimycotics in Infusion Solutions -- Useful Websites.
  • 1. Translational Strategies for Development of Antibody-Based Therapeutics: An Overview / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp -- 2. Discovery Process for Antibody-Based Therapeutics / Heather H. Shih -- 3. Technologies for the Generation of Human Antibodies / Ramesh R. Bhatt, John S. Haurum and C. Geoffrey Davis -- 4. Application of Antibody Engineering in the Development of Next Generation Antibody-Based Therapeutics / Randall J. Brezski and Juan Carlos Almagro -- 5. Biophysical Considerations for Development of Antibody-Based Therapeutics / Andrew W. Drake and Giuseppe A. Papalia -- 6. Considerations in Establishing Affinity Design Goals for Development of Antibody-Based Therapeutics / Mohammad Tabrizi -- 7. Bioanalytical Considerations for Development of Antibody-Based Therapeutics: Pharmacokinetics and Immunogenicity / Cherryl B. Funelas and Scott L. Klakamp -- 8. Preclinical Considerations for Development of Antibody-Based Therapeutics in Oncology / Gregory Landes and Kathleen Elias -- 9. Factors Impacting the Tumor Localization and Distribution of Antibody-Based Therapeutics in Oncology / David C. Blakey -- 10. Preclinical Safety Considerations for the Development of Antibody-Based Therapeutics / Lolke de Haan -- 11. Application of Pharmacokinetic/Pharmacodynamic Modeling in the Development of Antibody-Based Therapeutics / Donald E. Mager -- 12. Application of Population Pharmacokinetic-Pharmacodynamic Approaches in the Design of Translational Strategies for Development of Antibody-Based Therapeutics / Feng Jin -- 13. Translational Biomarkers: Essential Tools in Development of Antibody-Based Therapeutics / Mohammad A. Tabrizi and Cherryl B. Funelas -- 14. Translational Research in Alzheimer's Disease for Development of Antibody-Based Therapeutics / Eric C. Yuen, Enchi Liu and Gene G. Kinney -- 15. Considerations in Manufacturing Process Development for Antibody-Based Therapeutics / Paula C. Miller and Peiling Xu -- 16. Strategies for Development of Next Generation Antibody-Based Therapeutics / Mohammad Tabrizi and Gadi Gazit Bornstein -- 17. Immune Complex Therapies for Treatment of Immune Thrombocytopenia / Rong Deng and Joseph P. Balthasar -- 18. Application of Bioinformatics Principles for Target Evaluation / Anthony Carvalloza, Mohammad Fallahi and Sahba Tabrizifard -- 19. Concluding Remarks / Mohammad Tabrizi, Gadi Gazit Bornstein and Scott L. Klakamp.
  • Hepatitis C virus infection : from discovery to eradication / Masao Omata & Tatsuo Kanda -- Interferons in clinical trials / Tatsuo Kanda, Osamu Yokosuka & Masao Omata -- Protease inhibitors / Marion Corouge, Philippe Sogni & Stanislas Pol -- NS5A inhibitor : daclatasvir / Kazuaki Chayama & C. Nelson Hayes -- Toll-like receptor agonists for nonresponders to HCV treatment : hope versus promise? / Valérie Martel-Laferrière & Douglas Dieterich -- Treatment options in HIV-HCV-coinfected patients / Philippe Sogni, Marion Corouge & Stanislas Pol -- Treatment options for dual HCV/HBV coinfection / Chun-Jen Liu & Jia-Horng Kao -- HCV treatment in patients with metabolic syndrome / Luigi E. Adinolfi, Rosa Zampino, Luciano Restivo, Amedeo Lonardo & Paola Loria -- Future directions in hepatitis C therapy / Stevan A. Gonzalez -- Index.
  • Chapter 1. The evolving threat of antimicrobial resistance: Introduction -- Chapter 2. Surveillance to track antimicrobial use and resistance in bacteria -- Chapter 3. Measures to ensure better use of antibiotics -- Chapter 4. Reducing antimicrobial use in animal husbandry -- Chapter 5. Infection prevention and control in health-care facilities -- Chapter 6. Fostering innovation to combat antimicrobial resistance -- Chapter 7. The way forward: political commitment to enable options for action -- Appendix 1. List of 2001 WHO Global Strategy for Containment of Antimicrobial Resistance recommendations -- Appendix 2. List of 2011 WHO World Health Day six-point policy briefs.
  • This volume thoroughly covers HIV-1 antiretrovirals currently in clinical use, together with their advantages and limitations. HIV-1 inhibitor resistance is discussed in detail, and critical assessments as to what will be required of future antiretrovirals in order to halt viral replication, reduce viral resistance, and alter the state of viral latency are presented. Experts at the forefront of HIV-1 research provide overviews of approaches from the fields of virology, chemical biology and structural biology for obtaining small molecule inhibitors that target viral regulatory and structural components at multiple points in the viral lifecycle.
  • Infectious agents and drugs of choice / Julia A. McMillan, Julia A. McMillan and George K. Siberry -- Recommended empiric antimicrobial therapy for selected clinical syndromes / Hiwot Hiruy, Swathi Gowtham, and Paul Sue -- Drug dosing in special circumstances / Angela Helder, Elizabeth A. Sinclair, and Carlton K.K. Lee -- Mechanisms of action and routes of administration of antimicrobial agents / Karen C. Carroll -- Mechanisms of drug resistance / Karen C. Carroll -- Therapeutic drug monitoring / Kristine A. Parbuoni and Carlton K.K. Lee -- Adverse drug reactions / Melissa D. Makii and Carlton K.K. Lee -- Recommended antimicrobial prophylaxis for selected infectious agents and conditions / Julia A. McMillan and George K. Siberry -- Antimicrobial desensitization protocols / Lisa A. Degnan and Carlton K.K. Lee -- Formulary / Carlton K.K. Lee.
  • Antibacerial Drugs -- Antiviral Drugs, Including Immunoglobulins and Interferons -- Antifungal Drugs -- Antiprotozoal and Antihelminthic Drugs -- Vaccines -- Disinfectants and Antiseptics.
  • Antibiotic resistance : postantibiotic era is here / Vladimir Krcmery -- Current challenges in treating methicillin-resistant Staphylococcus aureus : what are the options? / Noha E.I. Sakka & Ian M . Gould -- Antimicrobial-resistant Streptococcus pneumoniae : trends and management / Michael R. Jacobs -- Emergence and management of drug-resistant enterococcal infections / William R. Miller, Barbara E. Murray & Cesar A. Arias -- Enterobacteriaceae that produce newer b-lactamases / Johann D.D. Pitout -- Extensively drug-resistant tuberculosis : new strains, new challenges / Megan Coffee -- Clinical significance of extended-spectrum b-lactamases / Jesés Rodréguez-Baño, Belén Gutiérrez, Lorena Lépez-Cerero & Alvaro Pascual -- Plasmid-mediated quinolone resistance / José Manuel Rodréguez-Marténez, Maréa Eliecer Cano, Jorge Calvo, Álvaro Pascual & Luis Marténez-Marténez -- Antibiotic resistance in the absence of antimicrobial use / Lucia Pallecchi, Alessandro Bartoloni, Eduardo Gotuzzo & Gian Maria Rossolini -- Resistance in bacteria of the food chain : epidemiology and control strategies / Lina Maria Cavaco & Frank Møller Aarestrup -- Measures to prevent antimicrobial resistance / Vhairi M. Bateman & Ian M. Gould -- Where does novel antibiotics R&D stand among other pharmaceutical products? / Glenn S. Tillotson -- Resistance to antiretroviral drugs / Manuela Colafigli, Simona Di Giambenedetto & Roberto Cauda -- Index.
  • Monoclonal antibodies targeting EGFR/HER2 and clinical outcomes in cancer treatment / Jan B. Vermorken -- Colorectal cancer / Christian Rolfo, Giuseppe Bronte, Antonio Russo & Marc Peeters -- Breast cancer / Sevilay Altintas -- Lung cancer and genitourinary cancers / Dirk Schrijvers -- Tumors of the skin, the CNS and the head and neck / Pol Specenier -- Gynecologic cancers / Jan B. Vermorken -- Index.

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