Books by Subject
- 2005-06 OvidBartlett, John G.
- 2010 ClinicalKeyFinch, R. G.1. Historical introduction -- 2. Modes of action -- 3. The problem of resistance -- 4. Pharmacodynamics of anti-infective agents: target delineation and susceptibility breakpoint selection -- 5. Antimicrobial agents and the kidneys -- 6. Drug interactions involving anti-infective agents -- 7. Antibiotics and the immune system -- 8. General principles of antimicrobial chemotherapy -- 9. Laboratory control of antimicrobial therapy -- 10. Principles of chemop rophylaxis -- 11. Antibiotic policies -- 12. Aminoglycosides and aminocyclitols -- 13. β-Lactam antibiotics : cephalosporins -- 14. β-Lactam antibiotics: penicillins -- 15. Other β-lactam antibiotics -- 16. Chloramphenicol and thiamphenicol -- 17. Diaminopyrimidines -- 18. Fosfomycin and fosmidomycin -- 19. Fusidanes -- 20. Glycopeptides -- 21. Lincosamides -- 22. Macrolides -- 23. Mupirocin -- 24. Nitroimidazoles -- 25. Oxazolidinones -- 26. Quinolones -- 27. Rifamycins -- 28. Streptogramins -- 29. Sulfonamides -- 30. Tetracyclines -- 31. Miscellaneous antibacterial agents -- 32. Antifungal agents -- 33. Antimycobacterial agents -- 34. Anthelmintics -- 35. Antiprotozoal agents -- 36. Antiretroviral agents -- 37. Other antiviral agents -- 38. Sepsis -- 39. Abdominal and other surgical infections -- 40. Infections associated with neutropenia and transplantation -- 41. Infections in intensive care patients -- 42. Infections associated with implanted medical devices -- 43. Antiretroviral therapy for HIV -- 44. Infections of the upper respiratory tract -- 45. Infections of the lower respiratory tract -- 46. Endocarditis -- 47. Infections of the gastrointestinal tract -- 48. Hepatitis -- 49. Skin and soft-tissue infections -- 50. Bacterial infections of the central nervous system -- 51. Viral infections of the central nervous system -- 52. Bone and joint infections -- 53. Infections of the eye -- 54. Urinary tract infections -- 55. Infections in pregnancy -- 56. Sexually transmitted diseases -- 57. Leprosy -- 58. Tuberculosis and other mycobacterial infections -- 59. Superficial and mucocutaneous mycoses -- 60. Systemic fungal infections -- 61. Zoonoses -- 62. Malaria -- 63. Other protozoal infections -- 64. Helminthic infections.
- 2012 SpringerDougherty, Thomas J.; Pucci, Michael J.
- 2011 SpringerGould, Ian M.; Meer, J. W. M. van der.
- 2007 SpringerGould, Ian M.; Meer, J. W. M. van der.
- 2012 SpringerCoates, Anthony R.M.Introduction to antibiotic resistance/ Richard Bax, David Griffin -- The origins of antibiotic resistance/ Gerard D. Wright -- Surveillance programmes and antibiotic resistance: worldwide and regional monitoring of antibiotic resistance trends/ Stephen Hawser -- Current and future challenges in the development of antimicrobial agents/ Robert P. Rennie -- The role of the outer membrane of gram-negative bacteria in antibiotic resistance: Ajax' shield or Achilles' heel?/ Malcolm G.P. Page -- Prevention of drug resistance by combined drug treatment of tuberculosis/ Denis A. Mitchison -- Nonmultiplying bacteria are profoundly tolerant to antibiotics / Yanmin Hu, Anthony Coates -- Persister cells: molecular mechanisms related to antibiotic tolerance / Kim Lewis -- Antimicrobial textiles / J. Vaun McArthur, R.C. Tuckfield, C. Baker-Austin -- Efflux: how bacteria use pumps to control their microenvironment / E. David G. McIntosh -- Antibiotics in phase II and III clinical trials / Anthony R.M. Coates, Gerry Halls.
- Antibiotic resistance : because of overuse and misuse, some antibiotics are losing effectiveness against highly resistant bacteria.2015This brief provides an overview of antibiotic resistance, including a summary of its current impact, the factors that contribute to its spread, and the policy recommendations put in place by federal and global public health agencies. It also reviews the debate around the regulation of antibiotic use in agriculture and examines new developments in policy and research associated with multidrug-resistant bacterial diseases and their underlying causes.
- Antibiotics : a survey of penicillin, streptomycin, and other antimicrobial substances from fungi, actinomycetes, bacteria, and plantsv. 1-2, 1949.Florey, Howard.
- Gallagher, Jason C.; MacDougall, Conan.Part 1. Considerations with antibiotic therapy -- Part 2. Antibacterial drugs -- Part 3. Antimycobacterial drugs -- Part 4. Antifungal drugs -- Part 5. Antiviral drugs -- Part 6. Antiparasitic Drugs -- Appendix 1. Selected normal human flora -- Appendix 2. Spectrum of activity -- Appendix 3. Empiric regimens for common infections -- Index.
- 1985-Regosz, A.; Tomlinson, E.v. 1. [Beta]-lactam antibiotics.
- 2010 SpringerShlaes, David M.
- Includes information on antimicrobial therapy and alternative therapy when the drug of choice cannot be given. The resource delivers information via review articles, capsule summaries, mini-reviews, and a guided PubMed search to pick up post-publication research.
- 2015 ScienceDirectChen, Chin-Yi; Jackson, Charlene R.; Yan, Xianghe.1. Introduction to antimicrobial-resistant foodborne pathogens / Patrick Butaye, Maria Angeles Argudín and John Threlfall -- 2. Antimicrobial resistance of Shiga toxin-producing Escherichia coli / Jinru Chen -- 3. Antibiotic resistance in pathogenic Salmonella / Steven C. Ricke and Juliany Rivera Calo -- 4. Antimicrobial resistance and Campylobacter jejuni and C. coli / Mirko Rossi, Satu Olkkola, Mati Roasto, Rauni Kivistö and Marja-Liisa-Hänninen -- 5. Antimicrobial resistance in Yersinia enterocolitica / Anna Fabrega, Clara Ballesté-Delpierre and Jordi Vila -- 6. Antimicrobial resistance in Vibrio species / Craig Baker-Austin -- 7. Antimicrobial resistance in Shigella species / Keith A. Lampel -- 8. Antimicrobial resistance in Listeria spp. / Nathan A. Jarvis, Philip G. Crandall, Corliss A. O'Bryan and Steven C. Ricke -- 9. Antibiotic resistance in Enterococci : a food safety perspective / Anuradha Ghosh and Ludek Zurek -- 10. Clostridium difficile: a food safety concern? / Jane W. Marsh and Lee H. Harrison -- 11. Methods for the detection of antimicrobial resistance and the characterization of Staphylococcus aureus isolates from food-producing animals and food of animal origin / Kristina Kadlec, Sarah Wendlandt, Andrea T. Fessler and Stefan Schwarz -- 12. Non-phenotypic tests to detect and characterize antibiotic resistance mechanisms in Enterobacteriaceae / Agnese Lupo, Krisztina M. Papp-Wallace, Robert A. Bonomo and Andrea Endimiani -- 13. Monitoring and surveillance : the national antimicrobial resistance monitoring system / Emily Crarey, Claudine Kabera and Heather Tate -- 14. Risk assessment of antimicrobial resistance / H. Gregg Claycamp -- 15. Food microbial safety and animal antibiotics / Louis Anthony (Tony) Cox -- 16. Antibiotic-resistant bacteria and resistance genes in the water-food nexus of the agricultural environment / Pei-Ying Hong -- 17. Development and application of novel antimicrobials in food and food processing / Yangjin Jung and Karl R. Matthews -- 18. Database resources dedicated to antimicrobial peptides / Guangshun Wang -- 19. Metabolic network analysis-based identification of antimicrobial drug target in pathogenic bacteria / Vinayak Kapatral -- 20. Application of metagenomic technologies for antimicrobial resistance and food safety research and beyond / Chin-Yi Chen, Xianghe Yan, Siyun Wang and Charlene R. Jackson.
- 2014 SpringerGenilloud, Olga; Marinelli, Flavia.Reports on the emergence and prevalence of resistant bacterial infections in hospitals and communities raise concerns that we may soon no longer be able to rely on antibiotics as a way to control infectious diseases. Effective medical care would require the constant introduction of novel antibiotics to keep up in the "arms race" with resistant pathogens. This book closely examines the latest developments in the field of antibacterial research and development. It starts with an overview of the growing prevalence of resistant Gram-positive and Gram-negative pathogens, including their various resistance mechanisms, prevalence, risk factors and therapeutic options. The focus then shifts to a comprehensive description of all major chemical classes with antibacterial properties, their chemistry, mode of action, and the generation of analogs; information that provides the basis for the design of improved molecules to defeat microbial infections and combat the emerging resistances. In closing, recently developed compounds already in clinical use, those in preclinical or first clinical studies, and a number of promising targets to be exploited in the discovery stage are discussed.
- 2008 CRCnetBASELewis, Kim; Salyers, Abigail A.; Taber, Harry; Wax, Richard G.Microbial drug resistance: a historical perspective / William C. Summers -- Ecology of antibiotic resistance genes / Abigail A. Salyers, Nadja Shoemaker, and David Schlesinger -- Global response systems that confer resistance / Paul F. Miller and Philip N. Rather -- Multidrug efflux pumps: structure, mechanism, and inhibition / Olga Lomovskaya ... [et al.] -- Mechanisms of aminoglycoside antibiotic resistance / Gerard D. Wright -- Resistance to [beta]-lactam antibiotics mediated by [beta]-lactamases : structure, mechanism, and evolution / Jooyoung Cha, Lakshmi P. Kotra, and Shahriar Mobashery -- Target modification as a mechanism of antimicrobial resistance / David C. Hooper -- Antibiotic permeability / Harry Taber -- Genetic methods for detecting bacterial resistance genes / Ad C. Fluit -- Evolution and epidemiology of antibiotic-resistant pneumococci / Christopher Gerard Dowson and Krzysztof Trzcinski -- Antimicrobial resistance in the enterococcus / George M. Eliopoulos -- Methicillin resistance in staphylococcus aureus / Keeta S. Gilmore, Michael S. Gilmore, and Daniel F. Sahm -- Mechanism of drug resistance in mycobacterium tuberculosis / Alex S. Pym and Stewart T. Cole -- Antibiotic resistance in enterobacteria / Nafsika H. Georgopapadakou -- Resistance as a worldwide problem / Paul Shears -- Public health responses to antimicrobial resistance in outpatient and inpatient settings / Cindy R. Friedman and Arjun Srinivasan -- Antibacterial drug discovery in the 21st century / Steven J. Projan.Also available: Print – 2008
- 2014 CRCnetBASESayen, S. M. Abu.Front Cover; About the Editor; Contents; Acknowledgment and How to Cite; List of Contributors; Introduction; Chapter 1: Potential Novel Therapeutic Strategies in Cystic Fibrosis: Antimicrobial and Anti-Biofilm Activity of Natural and Designed [alpha]-Helical Peptides Against Staphylococcus aureus, Pseudomonas aeruginosa, and Stenotrophomonas maltophilia; Chapter 2: Dispersal of Biofilms by Secreted, Matrix Degrading, Bacterial DNase. 1. Potential novel therapeutic strategies in cystic fibrosis : antimicrobial and anti-biofilm activity of natural and designed A-helical peptides against staphylococcus aureus, pseudomonas aeruginosa, and stenotrophomonas maltophilia / Arianna Pompilio, Valentina Crocetta, Marco Scocchi, Stefano Pomponio, Valentina Di Vincenzo, Mario Mardirossian, Giovanni Gherardi, Ersilia Fiscarelli, Giordano Dicuonzo, Renato Gennaro, and Giovanni Di Bonaventura -- 2. Dispersal of biofilms by Secreted, Matrix Degrading, Bacterial DNase / Reindert Nijland, Michael J. Hall, and J. Grant Burgess -- 3. The RNA processing enzyme polynucleotide phosphorylase negatively controls biofilm formation by repressing poly-n-acetylglucosamine (PNAG) production in escherichia coli C / Thomas Carzaniga, Davide Antoniani, Gianni Deh, ̣Federica Briani, and Paolo Landini -- 4. Comparative proteomic analysis of streptococcus suis biofilms and planktonic cells that identified biofilm infection-related immunogenic proteins / Yang Wang, Li Yi, Zongfu Wu, Jing Shao, Guangjin Liu, Hongjie Fan, Wei Zhang, and Chengping Lu -- 5. Anti-biofilm activity of an exopolysaccharide from a sponge-associated strain of bacillus licheniformis / S.M. Abu Sayem, Emiliano Manzo, Letizia Ciavatta, Annabella Tramice, Angela Cordone, Anna Zanfardino, Maurilio De Felice, and Mario Varcamonti -- 6. Osteopontin reduces biofilm formation in a multi-species model of dental biofilm / Sebastian Schlafer, Merete K. Raarup, Peter L. Wejse, Bente Nyvad, Brigitte M. Std̃ler, Duncan S. Sutherland, Henrik Birkedal, and Rikke L. Meyer -- 7. Impairment of the bacterial biofilm stability by triclosan / Helen V. Lubarsky, Sabine U. Gerbersdorf, Cďric Hubas, Sebastian Behrens, Francesco Ricciardi, and David M. Paterson -- 8. Antimicrobial pressure of ciprofloxacin and gentamicin on biofilm development by an endoscope-isolated pseudomonas aeruginosa / Idalina Machado, Joana Graȧ, Hľder Lopes, Susana Lopes, and Maria O. Pereira -- 9. Inhibition of staphylococcus epidermidis biofilm formation by traditional Thai herbal recipes used for wound treatment / S. Chusri, K. Sompetch, S. Mukdee, S. Jansrisewangwong, T. Srichai, K. Maneenoon, S. Limsuwan, and S.P. Voravuthikunchai -- 10. In vitro assessment of shiitake mushroom (lentinula edodes) extract for its antigingivitis activity / Lena Ciric, Anna Tymon, Egija Zaura, Peter Lingstrm̲, Monica Stauder, Adele Papetti, Caterina Signoretto, Jonathan Pratten, Michael Wilson, and David Spratt -- 11. Antimicrobial, antimycobacterial and antibiofilm properties of couroupita guianensis aubl. fruit extract / Naif Abdullah Al-Dhabi, Chandrasekar Balachandran, Michael Karunai Raj, Veeramuthu Duraipandiyan, Chinnasamy Muthukumar, Savarimuthu Ignacimuthu, Inshad Ali Khan, and Vikrant Singh Rajput -- 12. Fur is a repressor of biofilm formation in yersinia pestis / Fengjun Sun, He Gao, Yiquan Zhang, Li Wang, Nan Fang, Yafang Tan, Zhaobiao Guo, Peiyuan Xia, Dongsheng Zhou, and Ruifu Yang -- 13. Hsp90 governs dispersion and drug resistance of fungal biofilms / Nicole Robbins, Priya Uppuluri, Jeniel Nett, Ranjith Rajendran, Gordon Ramage, Jose L. Lopez-Ribot, David Andes, and Leah E. Cowen -- 14. Candida biofilms and the host : models and new concepts for eradication / Hľn̈e Tournu and Patrick Van Dijck -- 15. Innovative strategies to overcome biofilm resistance / Aleksandra Taraszkiewicz, Grzegorz Fila, Mariusz Grinholc, and Joanna Nakonieczna.
- 2006 CRCnetBASEFinch, R. G.; Pace, John L.; Rupp, Mark E.Microbial biofilms / Xiuping Jiang and John L. Pace -- Economic impact of biofilms on treatment costs / John G. Thomas, Isaiah Litton, and Harald Rinde -- Biofilm-related indwelling medical device infections / Matthew K. Schinabeck and Mahmoud A. Ghannoum -- Medical device composition and biological secretion influences on biofilm formation / Sean P. Gorman and David S. Jones -- Role of biofilms in infections caused by Escherichia coli / Grégory Jubelin, Corinne Dorel, and Philippe Lejeune -- Staphylococcus aureus biofilms / Julie M. Higashi and Paul M. Sullam -- Coagulase-negative staphylococci / Dietrich Mach ... [et al.] -- Pseudomonas aeruginosa biofilm infections in cystic fibrosis / Andrea Smiley and Daniel J. Hassett -- Candida / Stephen Hawser and Khalid Islam -- Current perspectives on the regulation of the ica operon and biofilm formation in Staphylococcus epidermidis / Paul D. Fey and Luke D. Handke -- Cell-to-cell communication in bacteria / Kenneth D. Tucker and Luciano Passador -- Persisters: specialized cells responsible for biofilm tolerance to antimicrobial agents / Kim Lewis ... [et al.] -- Minimal biofilm eradication concentration (MBEC) assay: susceptibility testing for biofilms / Howard Ceri ... [et al.] -- Environmental cues regulate virulence and biofilm formation / John L. Pace and Steven M. Frey -- In vivo models for the study of biomaterial-associated infection by biofilm-forming staphylococci / Luke D. Handke and Mark E. Rupp -- Host response to biofilms / Susan Meier-Davis -- Pharmacodynamics and the treatment of IMD-related infections / Roger Finch and Sarah Gander -- Protein synthesis inhibitors, fluoroquinolones, and rifampin for biofilm infections / Steven L. Barriere -- [beta][beta]-lactams for the treatment of biofilm-associated infections / Ingrid L. Dodge, Karen Joy Shaw, and Karen Bush -- Glycopeptide antibacterials and the treatment of biofilm-related infections / John L. Pace, Roasaire Verna, and Jan Verhoef -- Antibiotic resistance in biofilms / Nafsika H. Georgopapadakou -- Treatment protocols for infections of vascular catheters / Russell E. Lewis and Issam I Raad -- Treatment protocols for bacterial endocarditis and infection of electrophysiologic cardiac devices / Martin E. Stryjewski and G. Ralph Corey -- Treatment protocol of infections of orthopedic devices / Vera Antonios, Elie Berbari, and Douglas Osmon.
- 2012 CRCnetBASEAyyachamy, Manimaran; Gupta, Vijai Kumar.Identification of fungal pathogenicity genes by Agrobacterium tumefaciens-mediated transformation / Karunakaran Maruthachalam ... [et al.] -- The genetics and molecular biology of carotenoid biosynthesis in mucorales / Catalina Sanz, Mahdi Shahriari, and Arturo P. Eslava -- Induction and repression of carbohydrate degrading enzymes in fungi with special reference to their coding genes / Pauline Walsh, Alan Hernon, and Anthonia O'Donovan -- Involvement of ADH1, IPT1, and PMT genes in Candida albicans pathogenesis / Mahmoud Rouabhia and Mahmoud Ghannoum -- Enhanced resistance to fungal pathogens in plants through selective utilization of useful fungal genes / B.K. Sarma ... [et al.] -- Genes encoding penicillin and cephalosporin biosinthesis in Acremonium chrysogenum : two separate clusters are required for cephalosporin production / Juan-Francisco Martøn, Carlos Garcia-Estrada, and Ricardo V. Ullon -- A review of the fungal B-galactosidase gene and its biotechnological applications / Anne G. Lydon -- Trichoderma genes involved in interactions with fungi and plants / Mala Mukherjee -- Use of luciferases as a tool to analyze fungal physiology in association with gene transcription / David M. Arana and Jess Pla -- Fungal genes and their respective enzymes in industrial food, bio-based, and pharma applications / Marco van den Berg ... [et al.] -- Fungal metacaspases : an overview / Anthonia O'Donovan, Finola E. Cliffe, and Mary C. Shier -- Signaling molecules in the Arbuscular mycorrhizal fungi / Mohammad Miransari -- Role of pathogenic genes of Fusarium oxysporum, coding cell wall degrading enzymes during wilt infection in plants / Vijai Kumar Gupta, Maria Tuohy, and A. Manimaran -- Engineering fungal expression systems : recombinant expression of two class I alpha-1, 2-mannosidases from the filamentous fungus Aspergillus nidulans / C. Joshua Eades and William E. Hintz -- PCR-diagnostic of Septoria nodorum berk : aggresivenes in wheat tissue / I.V. Maksimov and A.Sh. Valeev -- Detection of toxigeneic and pathogenic fungi targeting metabolic pathway genes / Venkataramana Mudili ... [et al.] -- Pathogenicity genes in entomopathogenic fungia used as biopesticides / K. Uma Devi ... [et al.].
- 2012 WileyKay, Jack F.; MacNeil, James D.; Wang, Jian.Antibiotics : groups and properties / Philip T. Reeves -- Pharmacokinetics, distribution, bioavailability, and relationship to antibiotic residues / Peter Lees and Pierre-Louis Toutain -- Antibiotic residues in food, drinking water, and food safety regulations / Kevin J. Greenlees, Lynn G. Friedlander, and Alistair Boxall -- Sample preparation : extraction and clean-up / Alida A.M. (Linda) Stolker and Martin Danaher -- Bioanalytical screening methods / Sara Stead and Jacques Stark -- Chemical analysis : quantitative and confirmatory methods / Jian Wang and Sherri B. Turnipseed -- Single residue quantitative and confirmatory methods / Jonathan Tarbin [and others] -- Method development and method validation / Jack F. Kay and James D. MacNeil -- Measurement uncertainty / Jian Wang [and others] -- Quality assurance and quality control / Andrew Cannavan, Jack Kay, and Bruno Le Bizec.
- 2009 SpringerFrank, Uwe; Daschner, Franz; Tacconelli, Evelina.
- 2012 SpringerFrank, Uwe; Daschner, Franz; Tacconelli, Evelina.Classification of the Antibiotics -- Antibiotics Marketed in the EU -- Principles of Antibiotic Therapy -- The Most Common Errors in Antibiotic Therapy -- Important Infections and Their Microbiological Diagnosis -- Cooperation with Microbiologists -- Resistance of Major Clinical Pathogens -- The Most Frequent Pathogens- Choice of Antibiotics -- Antibiotics, Antimycotics: Spectrum- Dosage- Adverse Effects- Costs -- Antibiotic Therapy of the Principal Infections in Children and Adults -- Treatment of the Most Frequent Types of Bacterial Endocarditis -- Minimal Duration of Treatment for Bacterial Infections -- Failure of Antibiotic Therapy -- Fever of Unknown Origin: Differential Diagnosis -- Dosage of Antibiotics in Impaired Renal Function -- Antibiotic Therapy in Haemodialysis, Peritoneal Dialysis, and Continuous Haemofiltration -- Antibiotic Therapy During Pregnancy and Lactation -- Antibiotics in Liver Diseases -- Diffusion of Antibiotics in Cerebrospinal Fluid and in Cerebral Abscesses -- Local Antibiotics -- Prophylactic Antibiotic Therapy -- Physical Incompatibility of Antibiotics and Antimycotics in Infusion Solutions -- Useful Websites.
- 2012 WHOChapter 1. The evolving threat of antimicrobial resistance: Introduction -- Chapter 2. Surveillance to track antimicrobial use and resistance in bacteria -- Chapter 3. Measures to ensure better use of antibiotics -- Chapter 4. Reducing antimicrobial use in animal husbandry -- Chapter 5. Infection prevention and control in health-care facilities -- Chapter 6. Fostering innovation to combat antimicrobial resistance -- Chapter 7. The way forward: political commitment to enable options for action -- Appendix 1. List of 2001 WHO Global Strategy for Containment of Antimicrobial Resistance recommendations -- Appendix 2. List of 2011 WHO World Health Day six-point policy briefs.Also available: Print – 2012
- 2007Lesch, John E.Beginnings -- A system of invention -- Prontosil -- Into the maelstrom -- Accommodation and survival -- Pathways of recognition -- M&B 693 -- Acclaim and expansion -- At war -- Trial by fire -- A mechanism revealed -- The sulfa drugs and twentieth-century medicine.
- 2015 SpringerMaschmeyer, Georg; Rolston, Kenneth V. I.
- 2006Li, Jie Jack.Cancer drugs: from nitrogen mustards to Gleevec -- Drugs to kill germs -- Cardiovascular drugs: from nitroglycerin to Lipitor -- Sex and drugs -- Drugs of the mind -- Diabetes drugs -- Anesthetics -- Anti-inflammatory drugs -- Reflections.
- 2012 Latest year available.
- 1979-Hahn, F. E.
- Mechanistic studies and biomedical applications of antimicrobial peptoids against multi-drug resistant bacterial infections2011Kapoor, Rinki; Barron, Annelise E.; Contag, Christopher H.; Swartz, James R.The increasing prevalence of chronic, difficult-to-treat resistant bacterial infections have created a pressing need for the discovery of promising, novel pharmaceutical candidates that could replace or complement current therapies, which are becoming less reliable and effective due to a rise in bacterial resistance. Antimicrobial peptides (AMPs) are a naturally occurring, ubiquitous, and ancient class of antibiotics that offer a unique template for the development of novel antimicrobial therapies. However, in vivo therapeutic peptides have a short half-life since they are easily degraded by proteases, thus reducing their bioavailability, which renders them a less attractive choice therapeutically. Consequently, non-natural mimics of AMPs, which can emulate the favorable characteristics of AMPs are becoming significantly important. Poly-N-substituted glycines, also called "Peptoids", are structural and functional mimics of AMPs and are resistant to proteolysis. Predecessors in the Barron laboratory designed and characterized antimicrobial peptoids against free-floating, planktonic bacteria. However, almost 60% of infections are caused by bacterial biofilms. These complex communities of microorganisms are protected by an excreted matrix of adhesive biomacromolecules and are more difficult to kill with conventional antibiotics than planktonic bacteria. Furthermore, to develop peptoids as potential therapeutics, the mechanisms by which they interact with bacteria need to be understood, which are still under investigation. Here, we report that peptoids have similar or better efficacy than conventional antibiotics against biofilms of a clinical isolate of drug-resistant P. aeruginosa. We determined the effects of peptoids on bacterial biomass and cell viability, by Crystal Violet assay and bacterial plating, respectively. We also explored the efficacy of peptoids against Mycobacterium (an organism resistant to antibiotics due to the presence of a thick waxy coating) and intracellular L. monocytogenes by bioluminescent imaging. In addition, we also investigated the mechanisms of action of peptoids and peptides by biophysical techniques (Ultra-Violet Visible spectroscopy) and bioluminescent imaging. We report that peptoids are non-lytic and cause bacterial killing by aggregating the bacterial ribosomes and decreasing ATP levels inside the cell. Lastly, we present a mouse wound model, which suggests that peptoids are effective in vivo in reducing P. aeruginosa infections.
- Quantitative health risk analysis methods : modeling the human health impacts of antibiotics used in food animals2006 SpringerCox, Louis A.
- Selective digestive tract decontamination in intensive care medicine : a practical guide to controlling infection2007 SpringerVan Saene, H. K. F.; Voort, Peter H. J. van der.
- 2012Bynum, Helen.Tuberculosis is a complex and ancient disease that, after many years of virtual disappearance in the developed world, is now making something of a comeback. Helen Bynum tracks the historical development of the disease and considers the challenges it presents to the modern world.
- 2014 Latest year available.
- 2008Kollef, Marin H.
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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