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Allergy and ImmunologyAccess restricted to Stanford unless otherwise noted

  • Adenosine receptors 2007, CRCnetBASE
  • Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.
  • Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
  • "The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1 to 5 percent for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists." -- publisher's site.
  • Allergic disease: pathophysiology and immunopathology -- Approach to the allergic patient -- Diagnostic tests in allergy -- Environmental allergens -- Anaphylaxis -- Insect sting allergy -- The child with asthma -- Asthma in adults: diagnosis and management -- Allergic rhinitis: diagnosis and treatment -- Sinusitis and otitis media -- Diagnosis and treatment of ocular allergy -- Urticaria and angioedema -- Atopic dermatitis -- Contact dermatitis and other contact reactions -- Food allergy and intolerance -- Allergic and allergic-like reactions to drugs and other therapeutic agents -- Antihistamines -- β-adrenergic agonists -- Theophylline -- Antileukotriene agents in the management of asthma -- Cromolyn and nedocromil: nonsteroidal anti-inflammatory therapy for asthma and other allergic diseases -- Anticholinergic agents in respiratory diseases -- Glucocorticoid therapy in asthma -- Anti-IgE therapy -- Environmental control of respiratory indoor allergens -- Allergen immunotherapy -- Controversies in allergy and allergy-like diseases -- The patient with 'too many infections'.
  • Relations between asthma and psychological distress: an old idea revisited -- Brain and asthma: what are the linkages? -- Stress-related programming of autonomic imbalance: role in allergy and asthma -- Role of parasympathetic nerves and muscarinic receptors in allergy and asthma -- Developmental programming of allergic diseases -- Mind-body interrelationship in DNA methylation -- Neurotrophins in chronic allergic airway inflammation and remodeling -- Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system -- Allergen-induced neuromodulation in the respiratory tract -- Role of microbiome in regulating the HPA axisd and its relevance to allergy -- Autonomic regulation of anti-inflammatory activities from salivary glands -- Mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses -- Neural and behavioral correlates of food allergy -- Neuroendocrine-immune connection regulates chronic inflammatory disease in allergy -- Itch and the brain.
  • Allergy frontiers v. 1-6, 2009-2010., Springer
    v. 2, 2009 Springer
    v. 3, 2009 Springer
    v. 4, 2009 Springer
    v. 5, 2010 Springer
    v. 6, 2010 Springer
    v. 1. Epigenetics, allergens and risk factors -- v. 2. Classification and pathomechanisms -- v. 3. Clinical manifestations -- v. 4. Diagnosis and health economics -- v. 5. Therapy and prevention -- v. 6. Future perspectives.
  • Allergy in practice 2005, Springer
  • Allergy methods and protocols 2008, Springer Protocols
    Understanding of the molecular mechanisms of allergy /Meinir Jones --T cell : primary culture from peripheral blood /Monika Raulf-Heimsoth --Production of T-cell lines /Helga Kahlert --Production of human T-cell clones /Adrienne Verhoef --Mapping of human T-cell epitopes of allergens /Thomas ZeilerandTuomas Virtanen --Determining MHC restriction of T-cell responses /Mark Larché -- Short-term culture of CD8 cells and intracellular cytokine staining /Beejal VyasandAlistair Noble --Isolation, flow cytometric analysis, and suppression assay of CD4+ CD25+ T-regulatory cells /Hayley Jeal --Monocyte-derived dendritic cells as antigen-presenting cells in T-cell proliferation and cytokine production /Sun-sang J. Sung --Ultrasensitive ELISA for measurement of human cytokine responses in primary culture /William P. Stefura... [et al.] --Quantification of human chemokine production in TLR-stimulated and antigen-specific recall responses /Monique Stinson... [et al.] --Standardization of allergen extracts /Jørgen Nedergaard LarsenandSten Dreborg --Immunoelectrophoresis for the characterization of allergen extracts /Gitte Nordskov HansenandJørgen Nedergaard Larsen --Conjugation of haptens /Ranulfo LemusandMeryl H. Karol --Monoclonal antibodies /Helga KahlertandOliver Cromwell --Purification of antibodies /Per H. Larsson --Collection of air samples to quantify exposure to airborne allergens /Susan Gordon --Assay of air sample eluates /Anne RenströmandSusan Gordon --The halogen assay : a new technique for measuring airborne allergen /Euan Tovey... [et al.] --Measurement of specific IgG anti-Fel d 1 antibodies /Meinir G. Jones --The facilitated antigen binding (FAB) assay : a protocol to measure allergen-specific inhibitory antibody activity /James N. Francis --Microscopic identification and purity determination of pollen grains /Magdalena Rahl --Biopanning for the characterization of allergen mimotopes /Isabella Pali-SchöllandErika Jensen-Jarolim --Identification of mast cells and mast cell subpopulations /Mark BuckleyandAndrew F. Walls --Purification and characterization of mast cell tryptase and chymase from human tissues /Alan R. McEuenandAndrew F. Walls --Experimental activation of mast cells and their pharmacological modulation /Shaoheng HeandAndrew F. Walls --In situ hybridization /Kayhan T. Nouri-Aria.
  • Allergy. 4th ed. 2012, ScienceDirect
    Fulltext ClinicalKey
    The new edition of Allergy, by Drs. Stephen Holgate, Martin Church, David Broide, and Fernando Martinez, uses an enhanced clinical focus to provide the clear, accessible guidance you need to treat allergy patients. A more consistent format throughout features new differential diagnosis and treatment algorithms, updated therapeutic drug information in each chapter, and additional coverage of pediatric allergies. With current discussions of asthma, allergens, pollutants, drug treatment, and more, as well as access to the full text and illustrations online at www.expertconsult.com, this comprehensive resource is ideal for any non-specialist who treats patients with allergies. Prescribe appropriate therapies and effectively manage patients' allergies using detailed treatment protocols. Identify allergic conditions quickly and easily with algorithms that provide at-a-glance assistance. Explore topics in greater detail using extensive references to key literature.
  • Anaphylaxis 2010, Karger
    History and epidemiology -- History and classification of anaphylaxis -- Epidemiology of anaphylaxis -- Mechanisms -- T-cell response to allergens -- Anaphylaxis: mechanisms of mast cell activation -- Kinins, airway obstruction, and anaphylaxis -- Role for basophils in systemic anaphylaxis -- Human cardiac mast cells in anaphylaxis -- Diagnosis and clinical symptomatology -- Mastocytosis -- In vitro diagnosis of anaphylaxis -- Allergens and elicitors -- Insect venoms -- Classification and pathophysiology of radiocontrast media hypersensitivity -- Analgesics -- Anaphylaxis to general anesthetics -- Anaphylactic reactions to local anesthetics -- Treatment and prevention -- Anaphylaxis: acute treatment and management -- Epinephrine (adrenaline) in anaphylaxis.
  • Definition and criteria for the diagnoses of anaphylaxis -- An epidemiological approach to reducing the risk of fatal anaphylaxis -- Pathophysiology and organ damage in anaphylaxis -- Mast cells: effector cells of anaphylaxis -- Basophils in anaphylaxis -- Protease mediators of anaphylaxis -- Aspirin and NSAID reactions: diagnosis, pathophysiology, and management -- IgE-dependent and independent effector mechanisms in human and murine anaphylaxis -- Food-induced anaphylaxis -- Antibiotic-induced anaphylaxis -- Anaphylaxis during radiological procedures and in the peri-operative setting -- Hymenoptera-induced hypersensitivity reactions and anaphylaxis -- Idiopathic anaphylaxis -- Exercise-induced anaphylaxis and food-dependent exercise-induced anaphylaxis -- Mastocytosis and mast cell activation syndromes presenting as anaphylaxis -- Anaphylaxis in mastocytosis -- Flushing and urticarial syndromes presenting as anaphylaxis -- Pharmacologic management of acute anaphylaxis -- Drug desensitizations in the management of allergy and anaphylaxis to chemotherapeutic agents and monoclonal antibodies -- Rapid desensitizations for antibiotic-induced hypersensitivity reactions and anaphylaxis -- Induction of tolerance for food-induced anaphylaxis -- Management of anaphylaxis: relevance of causes and future trends in treatment.
  • History of research on angiogenesis -- Immune cells as a source and target of angiogenic and lymphangiogenic factors -- Neuropilins: role in signalling, angiogenesis and disease -- Class 3 semaphorin in angiogenesis and lymphangiogenesis -- Angiogenic and antiangiogenic chemokines -- Role of uPA/uPAR in the modulation of angiogenesis -- Neutrophil-derived cytokines involved in physiological and pathological angiogenesis -- Roles of eosinophils in the modulation of angiogenesis -- Regulatory T cells, leptin and angiogenesis -- Angiogenesis as a therapeutic target for obesity and metabolic diseases -- Angiogenesis in multiple myeloma -- Angiogenesis inhibitors in the treatment of prostate cancer -- Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease.
  • Antibody engineering 2004, Springer Protocols
  • Antibody fc 2014, ScienceDirect
    Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.
  • Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. ãaAnticarbohydrate Antibodies ãa from molecular basis to clinical applicationãa compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
  • Evolution of Antimicrobial Peptides: A View from the Cystine Chapel -- Innate Immunity in Plants: The Role of Antimicrobial Peptides -- Antimicrobial Peptides Produced by Microorganisms -- LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide -- Wound Repair and Antimicrobial Peptides -- WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2 -- Histatins: Multifunctional Salivary Antimicrobial Peptides -- Structure-Function Relationships of Antimicrobial Chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial Peptides and Inflammatory Bowel Disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial Peptides in Chronic Obstructive Pulmonary Disease -- Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo -- Helping the Host: Induction of Antimicrobial Peptides as a Novel Therapeutic Strategy Against Infections.
  • Part 1.History of Antiphospholipid Syndrome --1.Overview of the Last 25 Years and 13 International Congresses on Antiphospholipid Antibodies /Eon Nigel Harris and Silvia S. Pierangeli --Part II.Basic Science Aspects of Antiphospholipid Syndrome --2. What is the Oirgin of Antiphospholipid Antibodies? /Rohan Willis, Yehuda Shoenfeld, Silvia S. Pierangeli and Miri Blank --3.What is the Genetics of Antiphospholipid Antibodies/Syndrome? /Thomas L. Ortel, Pier Luigi Meroni, Marta E. Alarcón-Riquelme, Maria O. Borghi and Joan T. Merrill --4.What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Thrombosis? /Rohan Willis, Ian P. Giles, Pojen P. Chen, Chary López-Pedrera and María José Cuadrado, and Silvia S. Pierangeli --5.What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity? /Vikki M. Abrahams, Maria O. Borghi, Pier Luigi Meroni, Jacob H. Rand, Elena Raschi, Jane E. Salmon, Francesco Tedesco, and Angela Tincani --6.What are the Target Cells and Receptors that are Recognized by Antiphospholipid Antibodies? /Philip G. de Groot, Elena Raschi, Keith R. McCrae, Silvia S. Pierangeli, Panayiotis G. Vlachoyiannopoulos, and Rolf T. Urbanus --Part 3.13th Iinternational Congress on Antiphospholid Antibodies Task Force Reports --7.Task Force Report on "Criteria" Antiphospholipid Antibody Tests /Robert A. S. Roubey and Silvia S. Pierangeli --8.Task Force Report on "Non-criteria" Antiphospholipid Antibody Tests /Maria Laura Bertolaccini, Olga Amengual, Tatsuya Atsumi, Walter L. Binder, William H. Kutteh, Bas de Laat, [and others] --9.Task Force Report on Obstetric Antiphospholipid Syndrome /D. Ware Branch, Benjamin Leader and Carl A. Laskin --10.Task Force Report on Brain Involvement in Antiphospholipid Syndrome /Joab Chapman, Eyal Muscal and Robin L. Brey --11.Task Force Report on the Management of Thrombosis in Antiphospholipid Syndrome /Guillermo Ruiz-Irastorza, Vittorio Pengo, Maria G. Tektonidou, Ioana Ruiz-Arruza, María José Cuadrado, and Munther A. Khamashta --12.Task Force Report on Catastrophic Antiphospholipid Syndrome /Gerard Espinosa, Horacio Berman, Doruk Erkan and Ricard Cervera --13.Task Force Report on Non-criteria Manifestations: Thrombocytopenia /Gabriela Hernández-Molina, Xavier López-Karpovitch, Emilio B. González and Antonio R. Cabral --14.Task Force Report on Non-criteria Manifestations: Nephropathy /Maria G. Tektonidou, Horacio E. Adrogué and Smita Vaidya --15.Task Force Report on Non-criteria Manifestations: Cardiac Valve Disease /Gerard Espinosa, Lucía Fernández de Orueta, Elena Lluch, María Ángeles Polvorosa, Sandra Soro, and Ricard Cervera --16.Task Force Report on Non-criteria Manifestations: Skin /Michal Solomon, Yehuda Shoenfeld and Gisele Zandman-Goddard --17.Task Force Report on Antiphospholipid Syndrome Clinical Research /Doruk Erkan, Silvia S. Pierangeli and Michael D. Lockshin --Part 4.Future of Antiphospholipid Syndrome --18.What are the Potential Future Treatments in Antiphospholipid Syndrome? /Doruk Erkan, Anisur Rahman, Hannah Cohen, Samuel J. Machin and Silvia S. Pierangeli --19.Remembrances of Predictions Past /Michael D. Lockshin --Part 5.Antiphospholipid Syndrome for Patients --20.What Should Patients Know about Antiphospholipid Antibodies and Antiphospholipid Syndrome? /Doruk Erkan, Lindsay Lally and Michael D. Lockshin.
  • History / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Epidemiology / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Antiphospholipid Antibodies / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Classification Criteria for APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Mortality, Morbidity, and Damage Associated with aPL / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differences Between Primary and Secondary APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Clinical Features / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- aPL and Transplantation / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differential Diagnosis / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Management of APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta.
  • Death receptor signaling and its function in the immune system / Fas, S.C. ... [et al.] -- Inherited and acquired death receptor defects in human autoimmune lymphoproliferative syndrome / Rieux-Laucat, F. -- Tumor necrosis factor ligand-receptor superfamily and arthritis / Hsu, H.-C., Wu, Y., Mountz, J.D. -- Mitochondria, apoptosis and autoimmunity / Pinkoski, M.J., Waterhouse, N.J., Green, D.R. -- Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases / Hughes, P., Bouillet, P., Strasser, A. -- Mitochondria, cell death, and B cell tolerance / Deming, P.B., Rathmell, J.C. -- Role of complement and other innate immune mechanisms in the removal of apoptotic cells / Ogden, C.A., Elkon, K.B. -- Collectins: opsonins for apoptotic cells and regulators of inflammation / Stuart, L.M., Henson, P.M., Vandivier, R.W. -- MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure / Hanayama, R. ... [et al.] -- Clearance of apoptotic cells in human SLE / Gaipl, U.S. ... [et al.] -- Apoptosis and glomerulonephritis / Watson, S. ... [et al.].
  • History of immunology -- Molecules, cells, and tissues of the immune response -- Antigens and immunogens -- Major histocompatibility complex -- Antigen processing and presentation -- B lymphocyte development and immunoglobulin genes -- Immunoglobulin synthesis, properties, structure, and function -- Antigen-antibody interactions -- The thymus and T lymphocytes -- Cytokines and chemokines -- The complement system -- Types I, II, III, and IV hypersensitivity -- Immunoregulation and immunologic tolerance -- Autoimmunity -- Mucosal immunity -- Immunohematology -- Immunological diseases and immunopathology -- Immunophenotyping of hematopoietic malignancies -- Immunodeficiencies: congenital and acquired -- Acquired immune deficiency syndrome (AIDS) -- Immunomodulators -- Transplantation immunology -- Tumor immunology -- Immunity against microorganisms -- Vaccines and immunization -- Therapeutic immunology -- Comparative immunology -- Immunological methods and molecular techniques -- Diagnostic immunohistochemistry.
  • Atlas of Lymph Node Pathology reviews the histopathology of nodal diseases, illustrating the use of ancillary studies and includes concise discussions of pathogenesis, clinical settings and clinical significance of the pathologic diagnosis. The atlas features an overview of the benign reactive processes secondary to infectious, environmental or unknown insults, as well as relevant illustrations of virtually all primary and secondary neoplasms involving lymph nodes. The atlas also includes macroscopic images of some disorders, tables that help readers understand and comprehend diseases that look alike, and diagnostic algorithms for certain groups of diseases. Authored by highly experienced pathologists, Atlas of Lymph Node Pathology is a valuable resource that illustrates the vast majority of diseases practicing pathologists, clinicians and oncologists are likely to encounter in daily practice.
  • Atopic dermatitis is amongst the most common disorders of the skin in young people around the world. This book presents the newest insights and novel concepts in relation to all aspects of this skin disorder. Classification, clinical features and differential diagnosis are reviewed in the first chapter, while risk factors, susceptibility and an epidemiological overview are outlined in the next chapter, followed by a detailed discussion of the immunology of the skin and the pathophysiology of dermatitis. Further chapters present new data delineating clinical aspects of current genetic findings and insights into concepts of neuroimmunology, as well as the very crucial and severe clinical aspect of itching. New data on the topic of inhalant allergy, specific immunologic treatments and the latest on food allergy are also included.
  • Autism 2010, CRCnetBASE
    Type, topography, and sequelae of neuropathological changes shaping clinical phenotype of autism / Jerzy Wegiel ... [et al.] -- Evidence for oxidative damage in the autistic brain / Teresa A. Evans ... [et al] -- Oxidative stress and neurotrophin signaling in autism / Elizabeth M. Sajdel-Sulkowska -- Genetics of autism / W. Ted Brown -- The phenotypic expression of autism, maternal depression, and the monoamine oxidase-a gene / Ira L. Cohen -- Paraoxonase 1 status, environmental exposures, and oxidative stress in autism spectrum disorders / Maria Dronca and Sergiu P. Pasca -- The redox/methylation hypothesis of autism : a molecular mechanism for heavy metal-induced neurotoxicity / Richard C. Deth -- Autism and oxidative stress : evidence from an animal model / Michelle A. Cheh ... [et al.] -- Neurotoxic brainstem impairment as proposed threshold event in autistic regression / Woody R. McGinnis ... [et al.] -- Abnormalities in membrane lipids, membrane-associated proteins, and signal transduction in autism / Ved Chauhan and Abha Chauhan -- Mitochondrial component of calcium signaling abnormality in autism / J. Jay Gargus --Inflammation and neuroimmunity in the pathogenesis of autism : neural and immune network interactions / Carlos A. Pardo-Villamizar and Andrew W. Zimmerman -- Possible impact of innate immunity on autism / Harumi Jyonouchi -- Autism, gastrointestinal disturbance, and immune dysfunction : what is the link? / Paul Ashwood, Amanda Enstrom, and Judy van de Water -- Possible mechanism involving intestinal oxytocin, oxidative stress, and signaling pathways in a subset of autism with gut symptoms / Martha G. Welch and Benjamin Y. Klein -- Cytokine polymorphisms in autism : their role in immune alterations / Fabián Crespo ... [et al.] -- Autism, teratogenic alleles, HLA-DR4, and immune function / William G. Johnson ... [et al.] -- Autism : the centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy / Martha R. Herbert -- A re-evaluation of the state of autism treatment : the need for a biopsychosocial perspective / Eric London.
  • Autoimmune disease 2013, Springer
    This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
  • Autoimmune diseases 2011, Springer
    Assessment and Management of the Rheumatological Patient in the Critical Care Unit -- Life-Threatening Complications of Systemic Lupus Erythematosus -- Catastrophic Antiphospholipid Syndrome -- Complex Situations in Rheumatoid Arthritis -- Sjögren's Syndrome: Beyond Sicca Involvement -- Systemic Sclerosis: Severe Involvement of Internal Organs -- Vasculitic Emergencies in Patients with Large-Vessel Vasculitis -- Life-Threatening Presentations of ANCA-Associated Vasculitis -- Severe Polyarteritis Nodosa -- Life-Threatening Cryoglobulinemia -- Behçets Syndrome: Clinical Presentations Affecting Prognosis and Survival -- Myositis: When Weakness Can Kill -- Complicated Sarcoidosis: Challenges in Dealing with Severe Manifestations -- Complex Situations in Patients with Adult-Onset Still's Disease -- Managing Acute and Complex Dermatological Situations -- Life-Threatening Autoimmune Hematological Disorders -- Autoimmune Ear, Nose, and Throat Emergencies -- Ophthalmological Emergencies in Rheumatic and Autoimmune Diseases -- Emergencies for the Vascular Surgeon -- Complicated Pregnancies in Patients with Autoimmune Systemic Diseases -- The Complex Management of Viral-Related Autoimmune Diseases -- The Role of Intravenous Immunoglobulins in the Management of Acute Complex Autoimmune Conditions -- Life-Threatening Complications of Biological Therapies.
  • Pathogenesis of autoimmune diseases / Martin Röcken and Tilo Biedermann -- Autoantibody detection using indirect immunofluorescence on HEp-2 cells / Philipp von Landenberg -- Pemphigus / Michael Hertl and Rüdiger Eming -- Bullous pemphigoid : clinical features, diagnostic markers, and immunopathogenic mechanisms / Giovanni Di Zenzo ... [et al.] -- Dermatitis herpetiformis duhring / Christian Rose and Detlef Zillikens -- Epidermolysis bullosa acquisita / Gene Kim ... [et al.] -- Localized scleroderma / Cristián Vera Kellet, Catherine H. Orteu, and Jan P. Dutz -- Progressive systemic scleroderm / Nicolas Hunzelmann and Thomas Krieg -- Chronic cutaneous lupus erythematosus / Michael Sticherling -- Subacute cutaneous and systemic lupus erythematosus / Donna M. Pellowski, Jane E. Kihslinger, and Richard D. Sontheimer -- Dermatomyositis / Ruth Ann Vleugels and Jeffrey P. Callen -- Mixed connective tissue disease / Reiji Kasukawa -- Sjögren's Syndrome / Robert I. Fox and Carla M. Fox -- Psoriasis vulgaris and arthopathica / Arnd Jacobi and Jörg Christoph Prinz -- Chronic urticaria as an autoimmune disease / Clive Grattan, Michihiro Hide, and Malcolm W. Greaves -- Lichen planus, lichenoid eruptions and cutaneous grant-versus-host-reaction / Miklós Simon, Jr. -- Small vessel vasculitides / Peter Lamprecht and Wolfgang L. Gross -- Skin manifestations of rheumatic diseases / Camille Francés and Nicolas Kluger -- Vitiligo / Karin U. Schallreuter -- Alopecia areata / Pia Freyschmidt-Paul, Kevin McElwee, and Rolf Hoffmann -- Autoimmune phenomena in atopic dermatitis / Caroline Bussmann and Natalija Novak -- Eosinophils in autoimmune bullous diseases / Dagmar Simon and Hans-Uwe Simon -- Paraneoplastic syndromes of the skin / Peter Fritsch -- Targeted therapies in autoimmune and inflammatory skin disorders / Rüdiger Eming and Ingo H. Tarner.
  • Fulltext ClinicalKey
  • Autoimmunity 2004, Springer Protocols
    Generation, maintenance, and adoptive transfer of diabetogenic T-cell lines/clones from the nonobese diabetic mouse / Martha J. Milton ... [et al.] -- Experimental use of murine lupus models / Stanford L. Peng -- The anti-DNA knock-in model of systemic autoimmunity induced by the chronic graft-vs-host reaction / Robert Eisenberg and Arpita Choudhury -- Murine models of lupus induced by hypomethylated T cells / Bruce Richardson, Donna Ray, and Raymond Yung -- The mouse model of collagen-induced arthritis / David D. Brand, Andrew H. Kang, and Edward F. Rosloniec -- Proteoglycan aggrecan-induced arthritis: a murine autoimmune model of rheumatoid arthritis / Tibor T. Glant and Katalin Mikecz -- Mouse models of multiple sclerosis : experimental autoimmune encephalomyelitis and Theiler's virus-induced demyelinating disease / Kevin G. Fuller ... [et al.] -- Experimental autoimmune encephalitomyelitis / Praveen Rao and Benjamin M. Segal -- Animal models of scleroderma / Gabriella Lakos, Shinsuke Takagawa, and John Varga -- Rodent models of experimental autoimmune uveitis / Rajeev K. Agarwal and Rachel R. Caspi -- Autoimmune depigmentation following sensitization to melanoma antigens / Arthur A. Hurwitz and Qingyong Ji.Pathogenesis and spectrum of autoimmunity / Andras Perl -- Mapping the systematic lupus erythematosus susceptibility genes / Swapan K. Nath [et al.] -- T cell signaling abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar, Sandeep Krishnan, and George C. Tsokos -- TCR chain abnormalities in human systemic lupus erythematosus / Madhusoodana P. Nambiar ... [et al.] -- Protein kinase A and signal transduction in T lymphocytes : biochemical and molecular methods / Islam U. Khan and Gary M. Kammer -- Apoptosis and mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus / Andras Perl ... [et al.] -- Methods for inducing apoptosis / Kathryn M. Roberts, Antony Rosen, and Livia A. Casciola-Rosen -- Measurement of cytokines in autoimmune disease / Kyriakos A. Kirou, Christina Lee, and Mary K. Crow -- Evaluation of autoimmunity to transaldolase in multiple sclerosis / Brian Niland and Andras Perl -- Animal models for autoimmune myocarditis and autoimmune thyroiditis / Daniela Ciháková ... [et al.] -- Animal models of insulin-dependent diabetes mellitus / Edwin Liu ... [et al.] --
  • Autophagosome and phagosome 2008, Springer Protocols
    Autophagosome and phagosome / V. Deretic -- Fine structure of the autophagosome / E.L. Eskelinen -- Methods for assessing autophagy and autophagic cell death / E. Tasdemir ... [et al.] -- LC3 and Autophagy / I. Tanida, T. Ueno and E. Kominami -- Amino Acid regulation of autophagosome formation / A.J. Meijer -- Autophagic proteolysis of long-lived proteins in nonliver cells / E.A. Roberts and V. Deretic -- Autophagosomes in GFP-LC3 Transgenic Mice / N. Mizushima and A. Kuma -- Experimental control and characterization of autophagy in Drosophila / G. Juhasz and T.P. Neufeld -- Analysis of autophagosome membrane cycling by fluorescence microscopy / J.E. Legakis and D.J. Klionsky -- Protein trafficking into autophagosomes / A. Young and S. Tooze -- Sphingolipids in macroautophagy / G. Lavieu ... [et al.] -- Molecular links between autophagy and apoptosis / I.A. Ciechomska, C.G. Goemans and A.M. Tolkovsky -- Clearance of mutant aggregate-prone proteins by autophagy / B. Ravikumar, S. Sarkar and D.C. Rubinsztein -- Localization and MHC Class II Presentation of Antigens Targeted for Macroautophagy / D. Schmid and C. Munz -- Chaperone-mediated autophagy / S. Kaushik and A.M. Cuervo --Microautophagy in the Yeast Saccharomyces cerevisiae / A. Uttenweiler and A. Mayer -- EM Analysis of Phagosomes / C. de Chastellier -- Analysis of phosphoinositide dynamics during phagocytosis using genetically encoded fluorescent biosensors / G. Cosio and S. Grinstein -- In vitro phagosome-endosome fusion / I. Vergne and V. Deretic -- Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome / R.M. Yates and D.G. Russell -- Maturation changes in purified phagosomes / R. Dieckmann ... [et al.] -- Large-scale purification of latex bead phagosomes from mouse macrophage cell lines and subsequent preparation for high-throughput quantitative proteomics / A. Rupper and J. Cardelli -- Class II MHC Antigen Processing in Phagosomes / L. Ramachandra, W.H. Boom and C.V. Harding -- Analyzing Association of the Endoplasmic Reticulum with the Legionella pneumophila-Containing Vacuoles by Fluorescence Microscopy / A. Ingmundson and C.R. Roy -- Fractionation of the Coxiella burnetii Parasitophorous Vacuole / D. Howe and R.A. Heinzen -- Bacterial Phagosome Acidification Within IFN-gamma-Activated Macrophages: Role of Host p47 Immunity-Related GTPases (IRGs) / S. Tiwari and J.D. Macmicking -- SopE-Mediated Recruitment of Host Rab5 on Phagosomes Inhibits Salmonella Transport to Lysosomes / R. Madan, G. Krishnamurthy and A. Mukhopadhyay -- The Mycobacterium tuberculosis Phagosome / E.A. Roberts and V. Deretic.
  • Autophagy v. 1-, 2014, ScienceDirect
    v. 2, 2014 ScienceDirect
    v.3, 2014 ScienceDirect
    Volume 1. Molecular mechanisms -- Volume 2. Role in general diseases -- Volume 3. Mitophagy.
  • Avian immunology. 2nd ed. 2014, ScienceDirect
    Provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, this book encompasses all aspects of innate and adaptive immunity in chickens.
  • B cell protocols 2004, Springer Protocols
    Characterization of B lymphopoiesis in mouse bone marrow and spleen / Richard R. Hardy and Susan A. Shinton -- Characterization of B-cell maturation in the peripheral immune system / Rita Carsetti -- Identification of B-cell subsets: an exposition of 11-color (Hi-D) FACS methods / James W. Tung ... [et al.] -- Analysis of B-cell life-span and homeostasis / Irmgard Förster -- Differentiation of B lymphocytes from hemotopoietic stem cells / Paulo Vieira and Ana Cumano -- Analysis of lymphocyte development and function using the RAG-deficient blastocyst complementation system / Faith M. Young, Carl A. Pinkert, and Andrea Bottaro -- Conditional gene mutagenesis in B-lineage cells / Stefano Casola -- Analysis of the germinal center reaction and in vivo long-lived plasma cells / Kai-Michael Toellner, Mahmood Khan, and Daniel Man-Yuen Sze -- T-cell-dependent immune responses, germinal center development, and the anaysis of V-gene sequences / Claudia Berek -- Introduction of genes into primary murine splenic B cells using retrovirus vectors / Kuo-I Lin and Kathryn Calame --Immunoglobulin class switching: in vitro induction and analysis / Sven Kracker and Andreas Radbruch -- In vitro and in vivo assays of B-lymphocyte migration / Chantal Moratz and John H. Kehrl -- Analysis of antigen-specific B-cell memory directly ex vivo / Louise J. McHeyzer-Williams and Michael G. McHeyzer-Williams -- B-cell signal transduction : tyrosine phosphorylation, kinase activity, and calcium mobilization / Tilman Brummer ... [et al.] -- Isolation of lipid rafts from B lymphocytes / Anu Cherukuri ... [et al.] -- Molecular single-cell PCR analysis of rearranged immunoglobulin genes as a tool to determine the clonal composition of normal and malignant human B cells / Ralf Küppers -- Analysis of B-cell immune tolerance induction using transgenic mice / Helen Ferry and Richard J. Cornall -- Analysis of B-cell signaling using DT40 B-cell line / Tomoharu Yasuda and Tadashi Yamamoto -- B-cell Development and pre-B-1 cell plasticity in vitro / Antonius G. Rolink.
  • Determinations of B cell fate in immunity and autoimmunity / Noelle, R.J.; Erickson, L.D. -- Regulatory roles for cytokine-producing B cells in infection and autoimmune disease / Lund, F.E. ... [et al.] -- The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease / Tedder, T.F. ... [et al.] -- Marginal zone B cell physiology and disease / Lopes-Carvalho, T.; Kearney, J.F. -- Dendritic cells control B cell growth and differentiation / Jego, G. ... [et al.] -- The biology of CD20 and its potential as a target for mAb therapy / Cragg, M.S. ... [et al.] -- B lymphocyte depletion in rheumatoid arthritis / Edwards, J.C.W.; Leandro, M.J.; Cambridge, G. -- Treatment of SLE with anti-CD20 monoclonal antibody / Looney, R.J.; Anolik, J.; Sanz, I. -- The biochemistry and biology of BAFF, APRIL and their receptors / Kalled, S.L.; Ambrose, C.; Hsu, Y.-M. -- The BAFF/APRIL system / Mackay, F. ... [et al.] -- Human B lymphocyte malignancies / Jelinek, D.F.; Darce, J.R. -- BlySfulness does not equal blissfulness in systemic lupus erythematosus / Stohl, W.
  • E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity /Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt --What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? /Ralf Rosenstein, Friedrich Götz --Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung /Michael Hogardt, Jürgen Heesemann --Lactobacillus: Host-Microbe Relationships /John O'Callaghan, Paul W. O'Toole --Bacterial Moonlighting Proteins and Bacterial Virulence /Brian Henderson, Andrew Martin --Symbionts and Pathogens: What is the Difference? /Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya --Ecology and Physiology of the Intestinal Tract /Michael Blaut --The Gut Microflora and Its Variety of Roles in Health and Disease /Julia-Stefanie Frick, Ingo B. Autenrieth --Host-Recognition of Pathogens and Commensals in the Mammalian Intestine /Oriana Rossi, Peter van Baarlen, Jerry M. Wells --Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age /Jing Cheng, Airi M. Palva, Willem M. de Vos.
  • Bioconjugation protocols 2004, Springer Protocols
  • Biological DNA sensor 2014, ScienceDirect
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
  • Bispecific antibodies 2011, Springer
    "The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A deeper understanding of effector cell biology and especially developments in the field of antibody engineering has led to the generation of new classes of bispecific antibodies capable of circumventing many of these obstacles. Furthermore, new applications were established for bispecific antibodies, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies, but also on emerging applications such as dual targeting strategies, i.e., the simultaneous inhibition of two targets (cytokines, receptors, etc.) are provided. This book is intended for a broad readership in the field of antibody engineering, mainly from the pharmaceutical and biotechnology sector, but also including academic researchers working in this field."--Publisher's website.
  • Preface -- Abbreviations -- 1. Introduction -- 2. Organization of the Data -- 3. ABO blood group system -- 4. MNS blood group system -- 5. P blood group system -- 6. Rh blood group system -- 7. Lutheran blood group system -- 8. Kell blood group system -- 9. Lewis blood group system -- 10. Duffy blood group system -- 11. Kidd blood group system -- 12. Diego blood group system -- 13. Yt blood group system -- 14. Xg blood group system -- 15. Scianna blood group system -- 16. Dombrock blood group system -- 17. Colton blood group system -- 18. Landsteiner-Wiener blood group system -- 19. Chido/Rodgers blood group system -- 20 Hh blood group system -- 21. Kx blood group system -- 22. Gerbich blood group system -- 23. Cromer blood group system -- 24. Knops blood group system -- 25. Indian blood group system -- 26. OK blood group system -- 27. RAPH blood group system -- 28. JMH blood group system -- 29. I blood group system -- 30. Globoside blood group system -- 31. GIL blood group system -- 32. Cost blood group collection -- 33. Ii blood group collection --34. Er blood group collection -- 35. Globoside blood group collection -- 36. Unnamed blood group collection -- 37. The 700 series of low incidence antigens -- 38. The 901 series of high incidence antigens -- 39. Antigen-based facts -- 40. Autoantibody-based and drug facts -- 41. Clinically useful information -- 42. Blood group system and protein-based facts -- 43. Lectins and polyagglutination information -- 44. Gene-based facts -- 45. Useful definitions.
  • Botulinum neurotoxins 2013, Springer
    The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
  • The Cytokine System --The Discovery of the Brain Immunomodulators --Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines Produced by NSO and NPV of Hypothalamus --Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action --Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin --Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection with Proline-Rich Polypeptides Galarmin and Its Structural Analogues in an Experimental Murine Model --Treatment of Clostridium Perfringens-induced Gas Gangrene by New Cytokines of Brain --Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection --Brain-Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone Marrow Progenitor cells --Antioxidant-Antiradical and Electron Donating Function of Galarmin and Gx-NH2 --Discussion --Summary.
  • Cancer and IgE 2010, Springer
  • Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
  • This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • CD137 pathway 2006, Springer
  • The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics / Arthur M. Friedlander -- Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases / Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld and Izhak Inbar, et al. -- Dynamics of Bacillus anthracis Infection and Control Mechanisms / Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui and Michèle Mock -- Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages / James B. Bliska -- The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence / Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim and Gideon Halperin, et al. -- The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence / Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy and Ayelet Zauberman, et al. -- Dissection of the Functions of the IglC Protein of Francisella tularensis / Jeanette E. Bröms, Moa Lavander and Anders Sjöstedt -- Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions / Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner and Rima Z. Shaikhutdinova, et al. -- The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization / Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen and Ayelet Zauberman, et al. -- Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process / Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre and Elisabeth Carniel -- Poxvirus Entry into Host Cells / Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte and P.S. Satheskumar -- Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host / Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely and Sharon Melamed, et al. -- Inhibitors of Innate Immunity from Vaccinia Virus / Geoffrey L. Smith -- Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts / Svetlana Bardenstein and Menachem Banai -- MMP-9 as a Marker for Vaccinia Virus Related Encephalitis / Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi and Udy Olshevsky, et al. -- Epidemic Cowpox Virus Infections in Germany / Andreas Kurth and Andreas Nitsche -- The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection / Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar and David Gur, et al. --Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) / Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein and Einat Ben-Arie, et al. -- Subtyping Biothreat Bacterial Pathogens / Paul Keim and Talima Pearson -- A Rapid Method for Bacillus anthracis Genotyping / Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss and Anat Zvi, et al. -- Tularemia - A Disease with an Uncertain Impact on Public Health / Roland Grunow, Daniela Jacob, Andrea Kühn and Herbert Nattermann -- Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections / Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen and Avigdor Shafferman -- Novel Live Vaccine Candidates Against Airborne Francisella tularensis / Wayne Conlan and Anders Sjöstedt -- Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) / Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson and Orit Gat, et al. -- Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates / Anat Zvi, Naomi Ariel and Avigdor Shafferman -- Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacity / Michael H. Lehmann, Melanie Kremer, Yasemin Suezer and Gerd Sutter -- Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection / Sharon Melamed, Nir Paran, Tomer Israely, Noam Erez and Shaul Reuveny, et al. -- A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity / V.A. Feodorova, L.N. Pan'kina, E.P. Savostina, O.S. Kuznetsov and N.P. Konnov, et al. -- Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies / Yinon Levy, Yehuda Flashner, Ayelet Zauberman, Avital Tidhar and Moshe Aftalion, et al. -- Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect / Ohad Mazor, Einat Ben-Arie, Adva Mechaly, Ronit Rosenfeld and Hadar Marcus, et al. -- The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores / Zeev Altboum, Haim Levy, Shay Weiss, Avi Pass and Nili Rothschild, et al. -- Reverse Vaccinology in Bacillus anthracis / Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru and Haim Grosfeld, et al.
  • pt. 1. Urticaria and angiodema -- pt. 2. Skin manifestation of drug allergy -- pt. 3. Allergic contact dermatitis -- pt. 4. Other allergies affecting skin and mucous membranes -- pt. 5. Immunologic diseases of the skin.
  • Rhinitis -- Chronic rhinosinusitis -- Allergic diseases of the eye -- Urticaria and angioedema -- Allergic contact dermatitis -- Hypersensitivity pneumonitis -- Atopic dermatitis -- Food allergy -- Drug allergy -- Anaphylaxis -- Eosinophilia and eosinophilic disorder -- Occupational asthma -- Asthma conundrums -- Mastocytosis -- Allergic bronchopulmonary aspergillosis -- HIV/AIDS and complications -- Disorders of immune regulation -- Autoimmune diseases -- Immune-mediated rheumatic diseases -- Immunodeficiency.
  • Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.
  • Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system / T.E. Lane, J.L. Hardison, and K.B. Walsh -- Cytokine and chemokine networks : pathways to antiviral defense / T.P. Salazar-Mather and K.L. Hokeness -- Herpes simplex virus and the chemokines that mediate the inflammation / D.J.J. Carr and L. Tomanek -- Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections / K.E. Peterson and B. Chesebro -- HIV-1 coreceptors and their inhibitors / N. Ray and R.W. Doms -- A viral conspiracy : hijacking the chemokine system through virally encoded pirated chemokine receptors / H.F. Vischer, C. Vink, and M.J. Smit.
  • Chronic inflammation 2013, CRCnetBASE
    Section I. Systems Biology of Inflammation and Regulatory Mechanisms -- Chapter 1. At the Interface between Acute and Chronic Inflammation / Yoram Vodovotz -- Chapter 2. The Cellular Component of Chronic Inflammation / Julie M. Roda, Tim D. Eubank -- Chapter 3. Mast Cells in Chronic Inflammation / Traci A. Wilgus, Brian C. Wulff -- Chapter 4. Hypoxia and Hypoxia-Inducible Factor in Inflammation / Kiichi Hirota -- Chapter 5. Bioactive Phospholipid Mediators of Inflammation / Sainath R. Kotha, Jordan D. Secor, Smitha Malireddy, Gowrishankar Gnanasekaran, Narasimham L. Parinandi -- Chapter 6. Hematopoietic Stem Cells in Atherosclerotic Development and Resolution / Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das -- Chapter 7. Inflammation as a Confounding Factor in Regenerative Medicine / Myron Allukian, Kenneth W. Liechty -- Chapter 8. NOX in the CNS / Annadora J. Bruce-Keller -- Chapter 9. Resolution of Inflammation / Amitava Das, Sashwati Roy -- Chapter 10. H2S in Inflammation / Hyun-Ock Pae, Hun-Taeg Chung -- Section II. Pathologies Associated with Inflammation -- Chapter 11. Is There a Connection between Inflammation and Oxidative Stress? / Chandrakala Aluganti Narasimhulu, Xueting Jiang, Zhaohui Yang, Krithika Selvarajan, Sampath Parthasarathy -- Chapter 12. Chronic Inflammation and Cancer / Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad, Bharat B. Aggarwal -- Chapter 13. Chronic Wounds and Inflammation / Jaideep Banerjee, Chandan K. Sen -- Chapter 14. Multiphasic Roles for TGF-Beta in Scarring / Praveen R. Arany, George X. Huang, Woo Seob Kim -- Chapter 15. Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress / Cameron Rink, Savita Khanna -- Chapter 16. Inflammatory Cascades in Autoimmune Disease / Amita Aggarwal, Arpita Myles -- Chapter 17. Shear Stress and Vascular Inflammation / John Noel, Shampa Chatterjee -- Chapter 18. NGF and Its Receptor System in Inflammatory Diseases / Anupam Mitra, Smriti K. Raychaudhuri, Siba P. Raychaudhuri -- Section III. Nutrition & Therapeutics for Inflammatory Diseases -- Chapter 19. Inflammation, Oxidative Stress, and Antioxidants / Naveen Kaushal, Vivek Narayan, Ujjawal H. Gandhi, Shakira M. Nelson, Anil Kumar Kotha, K. Sandeep Prabhu --Chapter 20. Lipid Biomarkers of Inflammation / Ginger L. Milne -- Chapter 21. Physical Activity and Inflammation / Edite Teixeira de Lemos, Flávio Reis -- Chapter 22. Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes / Philip C. Calder -- Chapter 23. Anti-Inflammatory Phytochemicals, Obesity, and Diabetes / Srujana Rayalam, MaryAnne Della-Fera, Clifton A. Baile -- Chapter 24. Anti-Inflammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome / George Q. Li, Ka H. Wong, Antony Kam, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski, Kelvin Chan -- Chapter 25. Epigenetics and Nutriepigenomics in Chronic Inflammatory Lung Diseases / Saravanan Rajendrasozhan, Isaac K. Sundar, Irfan Rahman -- Chapter 26. Biologics / Ananya Datta Mitra, Debasis Bagchi, Siba P. Raychaudhuri, Smriti K. Raychaudhuri -- Chapter 27. Disease Modifying Anti-Rheumatic Drugs / Nigil Haroon, Vinod Chandran -- Chapter 28. Nonsteroidal Anti-Inflammatory Drugs / Alakendu Ghosh, Pradyot Sinhamahapatra.
  • Cicatricial alopecia 2011, Springer
    Introduction -- Clinical Assessment of the Patient -- Dermatopathology -- Medical Management -- Mechanisms and Current Research -- Predominantly Lymphocytic Group -- Predominantly Neutrophilic Group -- Mixed Group -- End Stage Nonspecific Group -- Personal Experiences of Six Patients.
  • Clinical allergy 2009, Springer
  • Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs.This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.
  • The human immune response -- Organization of the immune system -- Innate immunity -- Antigen receptor genes, gene products, and co-receptors -- The major histocompatibility complex -- Antigens and antigen presentation -- B-cell development and differentiation -- T-cell development -- Cytokines and cytokine receptors -- Chemokines and chemokine receptors -- Lymphocyte adhesion and trafficking -- T-cell activation and tolerance -- Programmed cell death in lymphocytes and associated disorders -- Immunoglobulin function -- Regulatory T cells -- Helper T-cell subsets and control of the inflammatory response -- Cytotoxic T lymphocytes and natural killer cells -- Host defenses in the skin -- Host defenses at mucosal surfaces -- Complement in host deficiencies and diseases -- Phagocyte deficiencies -- Mast cells, basophils, and mastocytosis -- Eosinophils and eosinophilia -- Host defenses to extracellular bacteria -- Host defenses to intracellular bacteria -- Host defenses to spirochetes -- Host defenses to viruses -- Host defenses to protozoa -- Host defenses to helminths -- Approach to the evaluation of the immunodeficient patient -- Infections in the immunocompromised host -- Maturing of the fetal and neonatal immune system -- Aging and the immune system -- Primary antibody deficiencies -- Primary T-cell immunodeficiencies -- Inherited disorders of IFN-y-, IFN-a/€//\-, and NF-kB-mediated immunity -- HIV infection and acquired immunodeficiency syndrome -- External factors inducing immune deficiency -- Immunological mechanisms of airway diseases and pathways to therapy -- Urticaria, angioedema, and anaphylaxis -- Allergic reactions to stinging and biting insects -- Atopic and contact dermatitis -- Food allergy -- Eosinophil-associated gastrointestinal disorders -- Allergic disorders of the eye -- Drug hypersensitivity -- Occupational asthma -- Mechanisms of autoimmunity -- Interface of autoimmunity and immunodeficiency -- Systemic lupus erthematosus --Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Sjögren's syndrome -- Scleroderma-systemic sclerosis -- Inflammatory muscle diseases -- Spondyloarthritis -- Small and medium vessel primary vasculitis -- Large-vessel vasculitides -- Systemic autoinflammatory syndromes -- Antiphospholipid syndrome -- Immunohematologic disorders -- Bullous diseases of the skin and mucous membranes -- Immunology of psoriasis -- Myasthenia gravis -- Multiple sclerosis -- Autoimmune peripheral neuropathies -- Immunologic renal diseases -- Inflammation and atherothrombosis -- Autoimmune thyroid diseases -- Diabetes and related autoimmune diseases -- Immunologic lung diseases -- Sarcoidosis -- Immunologic ocular disease -- Immunologic diseases of the gastrointestinal tract -- Inflammatory hepatobiliary diseases -- Principles of tumor immunology -- Tumor immunotherapy -- Lymphoid leukemias -- Lymphomas -- Monoclonal gammopathies -- Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance -- Stem cell transplantation and immune reconstitution in immunodeficiency -- Hematopoietic stem cell transplantation for malignant diseases -- Thymic reconstitution -- Immunoglobulin therapy: replacement and immunomodulation -- Gene therapy -- Glucocorticoids -- Immunomodulating pharmaceuticals -- Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders -- Vaccines -- Immunotherapy of allergic disease -- Biologic modifiers of inflammatory diseases -- Assessment of proteins of the immune system -- Flow cytometry -- Assessment of functional immune responses -- Assessment of neutrophil function -- Assessment of human allergic diseases -- Molecular methods.
  • pt. 1. The growth of lupus -- 1. Lupus: An introduction -- 2. What is lupus? -- pt. 2. Lupus organ by organ -- 3. Skin --4. Tendons and joints -- 5. Kidney -- 6. The brain -- 7. Heart and blood vessels -- 8. Liver and gastrointestinal tract -- 9. Blood -- pt. 3. Diagnosis and treatment -- 10. Diagnosing lupus -- 11. Treatment -- pt. 4. Lupus-like disorders -- 12. Sjögren's syndrome -- 13. Hughes syndrome (the antiphospholipid syndrome) -- 14. Mixed connective tissue disease (and overlap syndromes) -- 15. Vasculitis -- pt. 5. Lupus-related topics -- 16. Lupus-related topics.
  • "Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
  • Complement therapeutics 2013, Springer
  • Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
  • Coxiella burnetii 2012, Springer
    History and Prospects of Coxiella burnetii Research /Karim E. Hechemy --Phylogenetic Diversity, Virulence and Comparative Genomics /Erin J. van Schaik and James E. Samuel --Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche /Katja Mertens and James E. Samuel --Lipopolysaccharide of Coxiella burnetii /Craig T. Narasaki and Rudolf Toman --Components of Protective Immunity /Guoquan Zhang, Yan Zhang and James E. Samuel --Proteome of Coxiella burnetii /Robert Ihnatko, Edward Shaw and Rudolf Toman --Coxiella Subversion of Intracellular Host Signaling /S. Kauser Hussain and Daniel E. Voth --The Coxiella burnetii Parasitophorous Vacuole /Eric Ghigo, María I. Colombo and Robert A. Heinzen --Coxiella burnetii Secretion Systems /Justin A. McDonough, Hayley J. Newton and Craig R. Roy --Role of Lipids in Coxiella burnetii Infection /Stacey D. Gilk --Axenic Growth of Coxiella burnetii /Anders Omsland --Developmental Biology of Coxiella burnetii /Michael F. Minnick and Rahul Raghavan --Genetic Manipulation of Coxiella burnetii /Paul A. Beare --Role of Innate and Adaptive Immunity in the Control of Q Fever /Christian Capo and Jean-Louis Mege --Immune Response and Coxiella burnetii Invasion /Amira Ben Amara, Yassina Bechah and Jean-Louis Mege --Antigenic Analysis for Vaccines and Diagnostics /Laura R. Hendrix and Chen Chen --Epidemic Q Fever in Humans in the Netherlands /Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever and Mirjam H. A. Hermans, et al. --Coxiella-like Endosymbionts /Jianmin Zhong --Molecular Typing of Coxiella burnetii (Q Fever) /Robert F. Massung, Sally J. Cutler and Dimitrios Frangoulidis.
  • Signal transduction in DC differentiation: winged messengers and Achilles' heel / Inna Lindner ... [et al.] -- Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation / Gabrielle T. Belz ... [et al.] -- Understanding the role of innate immunity in the mechanism of action of the live attenuated yellow fever vaccine 17D / Troy D. Querec and Bali Pulendran -- The function of local lymphoid tissues in pulmonary immune responses / Juan Moyron-Quiroz ... [et al.] -- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity / Jian-Ming Li and Edmund K. Waller -- It's only innate immunity but I like it / Emanuela Marcenaro ... [et al.] -- Innate tumor immune surveillance / Mark J. Smyth, Jeremy Swann, and Yoshihiro Hayakawa -- Regulation of adaptive immunity by cells of the innate immune system: bone marrow natural killer cells inhibit T cell proliferation / Prachi P. Trivedi ... [et al.] -- Induction and maintenance of CD8+ T cells specific for persistent viruses / Ester M.M. van Leeuwen, Ineke J.M. ten Berge, and René A.W. van Lier -- Germinal center-derived B cell memory / Craig P. Chappell and Joshy Jacob -- CD28 and CD27 costimulation of CD8+ T cells: a story of survival / Douglas V. Dolfi and Peter D. Katsikis -- CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses / Santiago Partida Sánchez ... [et al.] -- Vascular leukocytes: a population with angiogenic and immunosuppressive properties highly represented in ovarian cancer / George Coukos ... [et al.] -- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells / Alexandre Corthay -- Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi / Teresa Zelante ... [et al.].
  • Protective effects of type1 interferon in models of intestinal inflammation / Jongdae Lee ... [et al.] -- NK/DC complot / Emanuela Marcenaro ... [et al.] -- Detection of microbes by natural killer T cells / Yuki Kinjo, Mitchell Kronenberg -- Ontogeny of the secondary antibody response, origins and clonal diversity / Craig P. Chappell, Joseph Dauner, Joshy Jacob -- Role of PI3K signalling in the B cell response to antigen / Daniel J. Hodson, Martin Turner -- CD28, old dog, new tricks / Jayakumar R. Nair, Cheryl Rozanski, Kelvin P. Lee -- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection / Thomas Wirth, John T. Harty -- Effects of cancer immunotherapy regimens on primary vs. secondary immune responses and the potential impact on long-term antitumor responses / Kory L. Alderson, William J. Murphy -- New insights into classical costimulation of CD8+ T cell responses / Christine M. Bucks, Peter D. Katsikis -- Peripheral tolerance induction by lymph node stroma / Erika D. Reynoso, Je-Wook Lee, Shannon J. Turley.
  • Is transcription the dominant force during dynamic changes in gene expression? -- MicroRNAs: key components of immune regulation -- KIR/HLA: genetic clues for a role of NK cells in the control of HIV -- Natural killer cell licensing during viral infection -- Bridging innate NK cell functions with adaptive immunity -- Control of innate immunity by memory CD4 T cells -- Strategies and implications for prime-boost vaccination to generate memory CD8 T cells -- Blimp1: driving terminal differentiation to a T -- New role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis -- Impact of differential glycosylation on IgG activity -- Murine model of chronic respiratory inflammation -- Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1 -- Influenza vaccines: what do we want and how can we get it?
  • ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.
  • 1. Cross-disciplinary research stirs new challenges into the study of the structure, function, and systems biology of complement / Dimitrios Mastellos and John D. Lambris -- 2. Liver regeneration: a link to inflammation through complement / Robert A. DeAngelis, Maciej M. Markeiwski, and John D. Lambris -- 3. The Role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow / Ryan Reca ... [et al.] -- 4. Complement system and the eye / Purushottam Jha ... [et al.] -- 5. To regeneration ... with complement / Panagiotis A. Tsonis, John D. Lambris, and Katia Del Rio-Tsonis -- 6. Self, non-self and danger: a complementary view / Jörg Köhl -- 7. gClqR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation / Berhane Ghebrehiwet ... [et al.] -- 8. Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer? / Kristina Nilsson Ekdahl ... [et al.] -- 9. Diversified components of the bony fish complement system: more genes for robuster innate defense? / Miki Nakao ... [et al.] -- 10. C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection / Horea Rus, Cornelia Cudrici, and Florin Niculescu -- 11. The Double-edged flower: roles of complement protein C1q in neurodegenerative diseases / Andrea J. Tenner and Maria I. Fonseca -- 12. The Role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis / Nóra Terényi, József Prechl, and Anna Erdei -- 13. The Complement system: a potential target for stroke therapy / J. Mocco ... [et al.] -- 14. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia / Fletcher B. Taylor, Jr., Eric Hack, and Florea Lupu -- 15. Complement activation during sepsis in humans / Heike Schreiber ... [et al.] -- 16. Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects / Yee-Ling Wu ... [et al.] -- 17. A Minimum CR2 binding domain of C3d enhances immunity following vaccination / Joseph F. Bower and Ted M. Ross -- 18. Structure and function of ficolins / Yuichi Endo, Yu Liu, and Teizo Fujita -- 19. Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM) / Lieve Nuytinck ... [et al.] -- 20. Conformational complexity of complement component C3 / Bert J.C. Janssen and Piet Gros -- 21. Disease-associated sequence variations in factor H: a stuctural biology approach / Andrew P. Herbert ... [et al.] -- 22. Transdermal pharmacology of small molecule cyclic C5a antagonists / Lavinia M. Proctor ... [et al.] -- 23. Inactivation of complement by recombinant human C3 derivatives / Edzard Spillner, Johanna Kölln, and Reinhard Bredehorst -- 24. Complement analysis in clinic and research / Tom E. Mollnes and Michael Kirschfink -- 25. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers / Sarah J. Calano ... [et al.].
  • Pentraxins in Humoral Innate Immunity / Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino and Alberto Mantovani -- Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution / Gerardo R. Vasta -- The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells - An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids / Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin and Ewa Bryndza, et al. -- Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds / Elizabeth A. Grice and Julia A. Segre -- Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity / George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh and John D. Lambris -- A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects / Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo and John Trowsdale, et al. -- Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins / Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris and Brian V. Geisbrecht -- Granzyme B: A New Crossroad of Complement and Apoptosis / Mario Perl, Stephanie Denk, Miriam Kalbitz and Markus Huber-Lang -- Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis / Markus Bosmann and Peter A. Ward --Complement Involvement in Neovascular Ocular Diseases / Ryoji Yanai, Aristomenis Thanos and Kip M. Connor -- Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis / Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson and Kristina N. Ekdahl -- Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection / Qingguo Ruan and Youhai H. Chen -- Function of Act1 in IL-17 Family Signaling and Autoimmunity / Ling Wu, Jarod Zepp and Xiaoxia Li -- Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood / D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris and T. Espevik, et al. -- Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases / Beatriz Novoa and Antonio Figueras -- Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection / Heidi A. Schreiber and Matyas Sandor -- NK/DC Crosstalk in Anti-viral Response / Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta and Simona Sivori -- Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS / Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee and Matyas Sandor, et al. -- Nutritional Immunity: Homology Modeling of Nramp Metal Import / Mathieu F. M. Cellier.
  • Cytokine protocols 2004, Springer protocols
  • Cytokines and the brain 2008, ScienceDirect
  • Cytokines in human health 2007, Springer Protocols
    Introduction to cytokines as targets for immunomodulation / Theresa L. Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Hervé Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James E. Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca J. Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin ... [et al.] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy ... [et al.] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- Flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana G. Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth W. Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael J. Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes.
  • Cytokines. 2nd ed. 2007, CRCnetBASE
    1. Behavioral Effects of Cytokines: A Psychiatrist's Perspective / Ziad Kronfol -- 2. Worried to Death? Stress, Worry, and Immune Dysregulation in Health and HIV -- 3. Psychological Stress and Its Relationship to Cytokines and Inflammatory Diseases / Rama Murali, Margaret D. Hanson, and Edith Chen -- 4. Role of Cytokines in Depression / Ghanshyam N. Pandey and Yogesh Dwivedi -- 5. Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines / Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo -- 6. Stress, Cytokines, and Peripheral Analgesia / Peter John Cabot -- 7. Alexithymia, Stress, and Immunity / Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet -- 8. Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression / Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy -- 9. Stress, Opioid Peptides, and Immune Reponse / Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim -- 10. Met-Enkephalin in Oxidative Stress / Tihomir Balog, Sandra Soboc̆anec, Vis̆nja S̆verko, Helena Haberstock-Debić, and Tatjana Marotti -- 11. Chronic Stress Induces Death of Lymphocytes / Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi -- 12. Interleukin-10 and the Hypothalamic--Pituitary--Adrenal Axis / Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr. -- 13. Cytokines, Stress, and Depression / Adrian J. Dunn -- 14. Immunoconversion in Acute Phase Response / Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs -- 15. Interferon in Health and Disease / Nachum Dafny, Pamela B. Yang, and Stanley A. Brod -- 16. Neuropeptide Precursor Processing in Immunocytes: Involvement in Neuroimmune Communication / Robert Day and Michel Salzet -- 17.Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? / Paola Sacerdote, Sivia Franchi, and Cataldo Martucci -- 18. Human Retroviruses and the Cytokine Network / Massimo Alfano and Guido Poli -- 19. Psychiatric Toxicity of Interferon: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? -- 20. Role of Genetic Predisposition, Cytokines, and Neuroendocrine Response in Development of Thyroid Autoimmunity / Antonio Martocchia and Paolo Falaschi -- 21. Gender Differences, Stress, and Immunity / Nicholas P. Plotnikoff and Robert E. Faith.
  • Dendritic cells 2009, Springer
  • The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin --Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • Dermatologic immunity 2008, Karger
    Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
  • Detecting allergens in food 2006, CRCnetBASE
  • Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
  • Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
  • Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
  • Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
  • DNA vaccines. 2nd ed. 2006, Springer Protocols
    DNA vaccine design / Janet L. Brandsma -- Design of plasmid DNA constructs for vaccines / Donna L. Montgomery and Kristala Jones Prather -- Vaccination with messenger RNA / Stave Pascolo -- A stress protein-facilitated antigen expression system for plasmid DNA vaccines / Petra Riedl ... [et al.] -- In vitro assay of immunostimulatory activities of plasmid vectors / Weiwn Jiang, Charles F. Reich, and David S. Pisetsky -- Delivery of DNA vaccines using electroporation / Shawn Babiuk, Sylvia van Drunen Littel-van den Hurk, and Lorne A. Babiuk -- Needle-free injection of DNA vaccines: a brief overview and methodology / Kanakatte Raviprakash and Kevin R. Porter -- Needle-free delivery of veterinary DNA vaccines / Sylvia van Drunen Littel-van den Hurk, Shawn Babiuk, and Lorne A. Babiuk -- Surface-modified biodegradable microspheres for DNA vaccine delivery / Mark E. Keegan and W. Mark Saltzman -- A dendrimer-like DNA-based vector for DNA delivery: a viral and nonviral hybrid approach / Dan Luo ... [et al.] -- Identification of compartments involved in mammalian subcellular trafficking pathways by indirect immunofluorescence / Anne Doody and David Putnam -- Adjuvant properties of CpG oligonucleotides in primates / Daniela Verthelyi -- Complexes of DNA vaccines with cationic, antigenic peptides are potent, polyvalent CD8+ T-cell stimulating immunogens / Petra Riedl, Jörg Reimann, and Reinhold Schirmbeck -- Prime-boost strategies in DNA vaccines / C. Jane Dale ... [et al.] -- Modifying professional antigen-presenting cells to enhance DNA vaccine potency / Chien-Fu Hung, Mu Yang, and T.C. Wu -- Replicase-based DNA vaccines for allergy treatment / Sandra Scheiblhofer ... [et al.] -- Immunological responses of neonates and infants to DNA vaccines / Martha Sedegah and Stepen L. Hoffman -- DNA vaccines for allergy treatment / Richard Weiss, Sandra Sheiblhofer, and Josef Thalhamer -- Protection from autoimmunity by DNA vaccination against T-cell receptor / Thorsten Buch and Ari Waisman -- The use of bone marrow-chimeric mice in elucidating immune mechanisms / Akiko Iwasaki -- A simple method for the production of plasmid DNA in bioreactors / Kristin Listner, Laura Kizer Bentley, and Michel Chartrain -- Practical methods for supercoiled pDNA production / John Ballantyne -- Production of plasmid DNA in industrial quantities according to cGMP guidelines / Joachim Schorr ... [et al.] -- Large-scale, nonchromatographic purification of plasmid DNA / Jason C. Murphy, Michael A. Winters, and Sangeetha L. Sagar -- Assuring the quality, safety, and efficacy of DNA vaccines / James S. Robertson and Elwyn Griffiths.
  • Drug allergy 2013, Springer
    Adverse reactions to drugs and drug allergy: scope of this book --Classification and descriptions of allergic reactions to drugs -- Mechanisms of hypersensitivity -- Diagnosis of allergic reactions to drugs -- β-lacam antibiotics -- Other antimicrobial drugs -- Drugs and other agents used in anesthesia and surgery -- Opiod analgesic drugs -- Nonsteroidal anti-inflammatory drugs -- Contrast media -- Biologics -- Corticosteroids -- Drugs used for chemotherapy -- Proton pump inhibitors -- Postface-concluding remarks.
  • Dust mites 2009, Springer
    "The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.
  • ELISA guidebook. 2nd ed. 2009, Springer Protocols
  • This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
  • Endotoxins 2010, Springer
    Endotoxins: Lipopolysaccharides of Gram-negative bacteria / X. Wang and P.J. Quinn -- Purification and characterization of lipopolysaccharides / X. Wang ... [et al.] -- Endotoxins: Relationship between structure, function, and activity / K. Brandenburg, A.B. Schromm and T. Gutsmann -- The diversity of the core oligosaccharide in lipopolysaccharides / A. Silipo and A. Molinaro -- Salmonella-regulated lipopolysaccharide modifications / S.M. Richards, K.L. Strandberg and J.S. Gunn -- The variation of O antigens in Gram-negative bacteria / L. Wang, Q. Wang and P.R. Reeves -- Regulators of TLR4 signaling by endotoxins / A.F. McGettrick and L.A.J. O'Neill -- Membrane partitioning: Is location everything when it comes to endotoxin recognition? / M. Triantafilou and K. Triantafilou -- Endotoxin detection - from limulus amebocyte lysate to recombinant Factor C / J.L. Ding and B. Ho -- The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni / A.P. Moran -- The role of pseudomonas lipopolysaccharide in cystic fibrosis airway infection / S.M. Moskowitz and R.K. Ernst -- Development of small-molecule endotoxin sequestering agents / S.A. David and D. Sil -- Development of an anti-endotoxin vaccine for sepsis / A.S. Cross -- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants / C.B. Fox ... [et al.] -- Targeting endotoxin in the treatment of sepsis / J.-S. Rachoin, C.A. Schorr and R.P. Dellinger -- Lipopolysaccharides in rhizobium-legume symbioses / R.W. Carlson, L.S. Forsberg and E.L. Kannenberg -- Lipopolysaccharides and plant innate immunity / G. Erbs ... [et al.].
  • Introduction --Immune System and Atopic Disorders --Epigenetics --Epigenetics, Environment, and Allergic Diseases --Conclusions and Future Perspectives.
  • An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.
  • Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
  • Epitope mapping protocols. 2nd ed. 2009, Springer Protocols
    What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.
  • Filaggrin 2014, Springer
    Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
  • Food allergy 2012, ScienceDirect
    Fulltext ClinicalKey
    1. Overview of mucosal immunity and development of oral tolerance / Corinne Keet, Robert Wood -- 2. Food antigens / E. N. Clare Mills, Philip E. Johnson, Yuri Alexeev -- 3. Epidemiology of food allergy / Katrina J. Allen, Jennifer J. Koplin -- 4. Clinical overview of adverse reactions to foods / John M. Kelso -- 5. Atopic dermatitis and food allergy / Tamara T. Perry, Debra D. Becton, Stacie M. Jones -- 6. Food-induced urticaria and angioedema / Julia Rodriguez, Jesús F. Crespo -- 7. Pollen-food syndrome / Antonella Muraro, Cristiana Alonzi -- 8. Respiratory tract and food allergy / John M. James -- 9. Food-induced anaphylaxis and food associated exercise-induced anaphylaxis Motohiro Ebisawa -- 10. Eosinophilic gastroenteropathies (eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis) / Dan Atkins, Glenn T. Furuta -- 11. Food protein-induced enterocolitis syndrome, food protein-induced enteropathy, proctocolitis, and infantile colic / Stephanie Ann Leonard, Anna Nowak-Węgrzyn -- 12. Approach to the clinical diagnosis of food allergy / Jonathan O'B. Hourihane -- 13. In vivo and in vitro diagnostic methods in the evaluation of food allergy / S. Allan Bock -- 14. Oral food challenge procedures / Gideon Lack, George Du Toit, Mary Feeney -- 15. Management of food allergy and development of an anaphylaxis treatment plan / Jacqueline Wassenberg, Philippe Eigenmann -- 16. Patient education and empowerment / Kim Mudd, Robert Wood -- 17. Future therapies for food allergies / Anna Nowak-Węgrzyn, Hugh A. Sampson -- 18. Natural history and prevention of food allergy / Scott H. Sicherer, Atsuo Urisu -- 19. Diets and nutrition: cross-reacting food allergens / Vicki McWilliam -- 20. Diagnostic and therapeutic dilemmas: adverse reactions to food additives, pharmacologic food reactions, psychological considerations related to food ingestion / John O. Warner.
  • Food allergy 2014, CRCnetBASE
    Chapter 1. Clinical manifestations of food allergy / Jonathan M. Spergel and Hemant P. Sharma -- Chapter 2. Prevalence, triggers, and cross-reactivity / Lynette P. Shek and Katrina (Katie) J. Allen -- Chapter 3. Acute reactions and anaphylaxis / Corinne Keet and Julie Wang -- Chapter 4. Skin conditions associated with food allergy / Tamara T. Perry, A. Wesley Burks, and Stacie M. Jones -- Chapter 5. Gastrointestinal conditions associated with food allergy / Mirna Chehade and Seema Aceves -- Chapter 6. Respiratory conditions associated with food allergy / John M. James -- Chapter 7. Diagnostic testing / Maeve Kelleher, S. Allan Bock, and Jonathan O'B Hourihane -- Chapter 8. The oral food challenge procedure / Sally Noone and Amal H. Assa'ad -- Chapter 9. Dietary management / Marion Groetch -- Chapter 10. Managing food avoidance within the home and outside the home, and lifestyle issues / Jennifer S. Kim, Eyal Shemesh, and Michael C. Young -- Chapter 11. Pharmacologic reactions to food and reactions to food additives / Matthew J. Greenhawt, Timothy J. Franxman, and Ronald A. Simon -- Chapter 12. Prevention / George Du Toit, David M. Fleischer, and Gideon Lack -- Chapter 13. Natural course / Jessica H. Savage and Robert A. Wood -- Chapter 14. Future diagnostics and therapies / Anna Nowak-Wegrzyn and Hugh A. Sampson -- Chapter 15. Practical resources for physicians and patients / Todd A. Mahr and Maria L. Acebal.
  • The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
  • TLR signaling / S. Akira -- Dendritic cells : translating innate to adaptive immunity / R.M. Steinman and H. Hemmi -- Helper T cell-regulated B cell immunity / L.J. Mcheyzer-Williams, L.P. Malherbe, and M.G. McHeyzer-Williams -- T cell memory / J.T. Tan an C.D. Surh -- The privacy of T cell memory to viruses / R.M. Welsh ... [et al.] -- Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA / M.J. McCluskie and A.M. Krieg.
  • Section I: Introduction to immunology --chapter 1.The immune system /William E. Paul --chapter 2.History of immunology /Steven Greenberg --Section II: Organization and evolution of the immune system --chapter 3.Lymphoid tissues and organs /Eitan M. Akirav ... [et al.] --chapter 4.Evolution of the immune system /Martin F. Flajnik and Louis Du Pasquier --Section III: Immunoglobulins and B-lymphocytes --chapter 5.Immunoglobulins: structure and function /Harry W. Schroeder Jr., David Wald, and Neil S. Greenspan --chapter 6.Immunoglobulins: molecular genetics /Edward E. Max and Sebastian Fugmann --chapter 7.Antigen-antibody interactions and monoclonal antibodies /Jay A. Berzofsky and Ira J. Berkower --chapter 8.B-lymphocyte development and biology /Richard R. Hardy --chapter 9.B-lymphocyte receptors, signaling mechanisms, and activation /Akanksha Chaturvedi ... [et al.] --chapter 10.B-lymphocyte responses /Michael McHeyzer-Williams --Section IV: T-lymphocytes --chapter 11.T-cell antigen receptors /Mark M. Davis and Yueh-Hsiu Chien --chapter 12.Mechanisms of T-lymphocyte signaling and activation /Takashi Saito --chapter 13.T-lymphocyte developmental biology /Ellen V. Rothenberg and Ameya Champhekar --chapter 14.Peripheral T-lymphocyte responses and function /Marc K. Jenkins --Section V: The intersection of innate and adaptive immunity --chapter 15.The innate immune system /Luke A. J. O'Neill --chapter 16.Dendritic cells /Kang Liu, Michel C. Nussenzweig --chapter 17.Natural killer cells /Wayne M. Yokoyama --chapter 18.CD1d-restricted natural killer T-cells /Albert Bendelac --chapter 19.Macrophages and phagocytosis /Siamon Gordon --chapter 20.Granulocytes and mast cells /Patrizia Scapini ... [et al.] --chapter 21.The major histocompatibility complex and its proteins /David H. Margulies ... [et al.] --chapter 22.Antigen processing and presentation /Ted H. Hansen and Paul A. Roche --Section VI: Induction, regulation, and effector functions of the immune response --chapter 23.Immunogenicity and antigen structure /Jay A. Berzofsky and Ira J. Berkower --chapter 24.Rc receptors and their role in immune regulation and inflammation /Jeffrey V. Ravetch and Falk Nimmerjahn --chapter 25.Type I cytokines and interferons, and their receptors /Warren J. Leonard --chapter 26.The interleukin-1 family /Charles A. Dinarello and Mihai G. Netea --chapter 27.Tumor necrosis factor-related cytokines in immunity /Carl F. Ware --chapter 28.Chemokines /Philip M. Murphy --chapter 29.Helper T-cell differentiation and plasticity /John J. O'Shea --chapter 30.Programmed cell death /Andrew L. Snow and Michael J. Lenardo --chapter 31.Immunologic memory /Shane Crotty, Susan M. Kaech, and Stephen P. Schoenberger --chapter 32.Immunologic tolerance /Christopher C. Goodnow and Pamela S. Ohashi --chapter 33.Regulatory/suppressor T-cells /Ethan M. Shevach --chapter 34.The mucosal immune system /Yasmine Belkaid --chapter 35.Neurophysiologic reflex mechanisms in immunology /Sangeeta S. Chavan and Kevin J. Tracey --chapter 36.Complement /B. Paul Morgan --chapter 37.Cell-mediated cytotoxicity /Judy Lieberman --Section VII: Immunity to infectious agents --chapter 38.The immune response to parasites /Thomas A. Wynn ... [et al.] --chapter 39.Immunity to viruses /Hildegund C. J. Ertl --chapter 40.Immunity to intracellular bacteria /Anca Dorhoi, Stephen T. Reece, and Stefan H. E. Kaufmann --chapter 41.Immunity to extracellular bacteria /Moon H. Nahm and Jannet Katz -- chapter 42.Immunology of human immunodeficiency virus infection /Douglas S. Kwon and Bruce D. Walker --chapter 43.Vaccines /Ennio De Gregorio ... [et al.] --Section VIII: Immunologic mechanisms in disease --chapter 44.Autoimmunity and autoimmune diseases /Ken T. Coppieters, Matthias G. von Herrath, and Dirk Homann --chapter 45.Immunologic mechanisms of allergic disorders /Marsha Wills-Karp and Ian Lewkowich --chapter 46.Transplantation immunology /Megan Sykes, Kathryn Wood, and David H. Sachs --chapter 47.Cancer immunology /Hans Schreiber --chapter 48.Inborn errors of immunity /Jean-Laurent Casanova, Mary Ellen Conley, and Luigi D. Notarangelo.
  • Over the past decade, significant progress has been made in the theory and applications of pharmacodynamics of antimicrobial agents. On the basis of pharmacokinetic-pharmacodynamic modeling concepts it has become possible to describe and predict the time course of antimicrobial effects under normal and pathophysiological conditions. The study of pharmacokinetic-pharmacodynamic relationships can be of considerable value in understanding drug action, defining optimal dosing regimens, and in making predictions under new or changing pre-clinical and clinical circumstances. Not surprisingly, pharmacokinetic-pharmacodynamic modeling concepts are increasingly applied in both basic and clinical research as well as in drug development. Fundamentals of Antimicrobial Pharmacokinetics and Pharmacodynamics is designed as a reference on the application of pharmacokinetic-pharmacodynamic principles for the optimization of antimicrobial therapy, namely pharmacotherapy, and infectious diseases. The reader is introduced to various aspects of the fundamentals of antimicrobial pharmacodynamics, the integration of pharmacokinetics with pharmacodynamics for all major classes of antibiotics, from basic research to clinical situations.
  • Fungal immunology 2005, Springer
  • Gamma-delta T cells 2001, Karger
    T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotection
  • Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
  • Gene vaccines 2012, Springer
  • Glioma 2012, Springer
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
  • Improving the sensitivity of the ELISPOT analyses of antigen-specific cellular immune responses in rhesus macaques / K. Jagannadha Sastry, Pramod N. Nehete, and Bharti Nehete -- Feline cytokine ELISPOT : issues in assay development / Sushila K. Nordone ... [et al.] -- Measuring T cell function in animal models of tuberculosis by ELISPOT / Vanja Lazarevic, Santosh Pawar, and JoAnne Flynn -- IFN-gamma ELISPOT assay for the quantitative measurement of antigen-specific murine CD8+ T cells / Geoffrey A. Cole -- Detection of measles virus-specific IFN-gamma secreting T cells by ELISPOT / Jenna E. Ryan, Inna G. Ovsyannikova, and Gregory A. Poland -- Epitope mapping in multiple sclerosis using the ELISPOT assay / Clara M. Pelfrey and Ioana R. Moldovan --The ELISPOT assay : a personal retrospective / Jonathan Sedgwick -- Chemistry and biology of the ELISPOT assay / Alexander E. Kalyuzhny -- Membranes and membrane plates used in ELISPOT / Alan J. Weiss -- Standardization and validation issues of the ELISPOT assay / Sylvia Janetzki ... [et al.] -- A cell detachment solution can reduce a background staining in ELISPOT assay : Accumax / Angela Grant ... [et al.] -- Isolation of subsets of immune cells / Carrie E. Peters, Steven M. Woodside, and Allen C. Eaves -- Image analysis and data management of ELISPOT assay results / Paul Viktor Lehmann -- High resolution as a key feature to perform accurate ELISPOT measurements using Zeiss KS ELISPOT readers / Wolf Malkusch --Use of IFN-gamma ELISPOT in monitoring immune responses in humans / Mark Matijevic and Robert G. Urban -- ELISPOT determination of IFN-gamma T cell frequencies in patients with autoimmune sensorineural hearing loss / C. Arturo Solares and Vincent K. Tuohy -- Dual color ELISPOT assay for analyzing cytokine balance / Yoshihiro Okamoto and Mikio Nishida -- Simultaneous detection of multiple cytokines in ELISPOT assays / Sarah Palzer ... [et al.] -- Fluorospot assay : methodological analysis / Agnes Gazagne ... [et al.] -- A gel-based dual antibody capture and detection method for assaying of extracellular cytokine secretion : EliCell / Lisa A. Spencer ... [et al.].
  • Overview of immunity / James D. Folds -- Statistics of immunological testing / Albert D. Donnenberg -- Human immunoglobulins / Robert G. Hamilton -- The complement system / Patricia C. Giclas -- Cellular immunology : monitoring of immune therapies / Theresa L. Whiteside -- Understanding clinical flow cytometry / Albert D. Donnenberg and Vera S. Donnenberg -- Leukemia and lymphoma immunophenotyping and cytogenetics / Maria A. Proytcheva -- Guidelines for the use of flow cytometry in the management of patients infected with the human immunodeficiency virus type-1 and the acquired immunodeficiency syndrome / Maurice R.G. O'Gorman -- Role of flow cytometry in the diagnosis and monitoring of primary immunodeficiency disease / Maurice R.G. O'Gorman -- Detection and characterization of the T-cell receptor repertoire / Gulbu Uzel -- Human leukocyte differentiation antigens, cluster of differentiation : past, present, and future / Maurice R.G. O'Gorman -- Immunologic diagnosis of autoimmunity / Noel R. Rose -- Autoimmune and immune-mediated diseases of the gastrointestinal tract / Stefano Guandalini, Mala Setty, and Bana Jabri -- Serologic testing for infectious diseases / John L. Schmitz -- Molecular techniques applied to infectious diseases / Jennifer S. Goodrich and Melissa B. Miller -- Cytokines : regulators of immune responses and key therapeutic targets / Barbara Detrick, Chandrasekharam N. Nagineni, and John J. Hooks -- Measuring human cytokines / Holden T. Maecker -- The human major histocompatibility complex and DNA-based typing of human leukocyte antigens for transplantation / Susana G. Marino, Andrés Jaramillo, and Marcelo A. Fernández-Viña -- Relevance of antibody screening and crossmatching in solid organ, hematopoietic stem cell transplantation, and blood transfusion / Chee L. Saw ... [et al.] -- Functional assessment of immunosuppression : monitoring posttransplant alloreactivity with flow cytometric mixed lymphocyte cocultures / Chethan Ashok Kumar ... [et al.].
  • Quality management and regulation / Jeffrey Prichard -- Technique and troubleshooting of antibody testing / Fan Lin and Jianhui Shi -- Overview of automated immunohistochemistry / Jeffrey Prichard, Angela Bitting, and Joe Myers -- Automated staining : Dako perspective / Ole F. Rasmussen and Andreas Schønau -- Automated staining : Ventana perspective / Angela Sattler -- Tissue microarray / Myra Wilkerson and Erin Powell -- Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens / Fan Lin and Haiyan Liu -- Exfoliative cytopathology / Steven Meschter and Jan F. Silverman -- Predictive markers of breast cancer : ER, PR, and HER2 / Jeffrey Prichard, David Hicks, and Elizabeth Hammond -- Central and peripheral nerve system tumors / Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller -- Thyroid and parathyroid gland / Haiyan Liu, Fan Lin, and Ronald A. DeLellis -- Adrenal gland / Hanna G. Kaspar -- Salivary gland and other head and neck structures / Conrad Schuerch -- Lung, pleura, and mediastinum / Kai Zhang and Phillip Cagle -- Breast / Haiyan Liu -- Uterus / Hanna G. Kaspar -- Ovary / Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson -- Prostate gland / Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai -- Urinary bladder / Myra Wilkerson -- Kidney / Fan Lin and Ximing J. Yang -- Testis and paratesticular tissues / Myra Wilkerson -- Pancreas and ampulla / Fan Lin and Hanlin L. Wang -- Liver, bile ducts, and gallbladder / Jeffrey Prichard and Fan Lin -- Upper gastrointestinal tract / Jinhong Li and Fan Lin -- Lower gastrointestinal tract and microsatellite instability / Jinhong Li and Fan Lin -- Soft tissue and bone tumors / Shaobo Zhu and Markku Miettinen -- Lymph node / Xiaohong (Mary) Zhang and Nadine S. Aguilera -- Bone marrow / R. Patrick Dorion and Xiaohong (Mary) Zhang -- Infectious diseases / Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner -- Skin / Tammie Ferringer -- Application of direct immunofluorescence for the skin and mucosal biopsies : a practical review / William B. Tyler -- In situ hybridization in surgical and cytologic specimens / Hong Yin and Barbara Paynton.
  • Handbook of systemic autoimmune diseases v. 1-, 2004-, ScienceDirect
  • Henipavirus 2012, Springer
    Introduction: Nipah Virus--Discovery and Origin /Kaw Bing Chua --Ecological Aspects of Hendra Virus /Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang --Epidemiology of Henipavirus Disease in Humans /Stephen P. Luby and Emily S. Gurley --Molecular Virology of the Henipaviruses /Paul A. Rota and Michael K. Lo --Henipavirus Receptor Usage and Tropism /Olivier Pernet, Yao E Wang and Benhur Lee --Henipavirus Membrane Fusion and Viral Entry /Hector C. Aguilar and Ronald M. Iorio --Clinical and Pathological Manifestations of Human Henipavirus Infection /K. T. Wong and C. T. Tan --Henipaviruses in Their Natural Animal Hosts /D. J. Middleton and H. M. Weingartl --Nipah and Hendra Virus Interactions with the Innate Immune System /Christopher F. Basler --Animal Challenge Models of Henipavirus Infection and Pathogenesis /Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder --Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions /Lin-Fa Wang and Peter Daniels --Immunization Strategies Against Henipaviruses /Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
  • Hepatitis C virus 2013, Springer
    Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
  • Innate immunity in type C hepatitis / Tetsuo Takehara and Norio Hayashi -- Mechanisms of interferon action and resistance in chronic hepatitis C virus infection: lessons learned from cell culture studies / Srikanta Dash ... [et al.] -- Immunological parameters influencing adaptive immune responses to the hepatitis C virus / Patrick Bertolino, Geoffrey W. McCaughan, and David G. Bowen -- Immune responses against the hepatitis C virus and the outcome of therapy / Paul Klenerman and Eleanor Barnes -- Other microbial components associated with hepatitis C virus infection: their effects on interferon- a/ribavirin treatment / Luigi Amati, Vittorio Pugliese, and Emilio Jirillo -- Interferon-induced effector proteins and hepatitis C virus replication / Michael Frese and Eva Dazert -- Treatment of chronic hepatitis C with different genotypes / James Fung, Ching-Lung Lai, and Man-Fung Yuen -- Interferon treatment of hepatitis C virus infection: from basic biology to clinical application / Norihiro Furusyo, Masayuki Murata, and Jun Hayashi -- Interferon-based therapy for hepatitis C virus infections / Ming-Lung Yu and Wan-Long Chuang -- Treatment of chronic hepatitis C in "difficult-to-treat" patients in the clinical setting / Ana Moreno, Rafael Bárcena, and Carmen Quereda -- Effects of combined IFN-alpha/ribavirin treatment in HCV disease-related progression / Davide Festi ... [et al.] -- Pegylated interferons: clinical applications in the management of hepatitis C infection / S. James Matthews and Christopher McCoy.
  • Heterogeneity in asthma 2014, Springer
    Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.
  • One hundred years of histamine research / Katherine Figueroa and Nigel Shankley -- Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs -- Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu -- Abstract -- Histamine in allergic rhinitis / Thomas Taylor-Clark -- The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.] -- The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate -- Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer -- Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff -- Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy -- Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula -- Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas -- The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond.
  • History of allergy 2014, Karger
  • History of modern immunology 2014, ScienceDirect
    A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author.
  • "The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases. However, no vaccine development has been easy and there is an interesting story attached to each. The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries. The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine."--Publisher's website.
  • HIV and the brain 2009, Springer
    Neurocognitive changes in AIDS: evolution of treatment of HIV infection / Erna Milunka Kojic and Charles C.J. Carpenter -- Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes, and epidemiology of hepatitis C infection among HIV-positive individuals / Karen T. Tashima and Aadia I. Rana -- New insights into HIV neuropathogenesis / Tory P. Johnson and Avindra Nath -- Neuropathological findings associated with long-term HAART / Iain C. Anthony and Jeanne E. Bell -- Biomarkers of HIV-related central nervous system disease / Bruce James Brew and Scott Letendre -- Neuroimaging among HIV-infected patients: current knowledge and future directions / David F. Tate ... [et al.] -- The assessment of HIV-associated neurocognitive disorders: new challenges in the HAART era / Lucette A. Cysique and Bruce J. Brew -- The changing face of HIV-associated cognitive and neuropsychiatric disturbance / Ron Cohen -- Youth with HIV/AIDS: neurobehavioral consequences / Susannah Allison, Pamela L. Wolters, and Pim Brouwers -- Co-occurrence of HIV, hepatitis C, and substance use disorders: effects on brain functioning / Raul Gonzalez, Phillip J. Quartana, and Eileen M. Martin -- The functional impact of HIV-associated neuropsychological decline / Matthew J. Wright ... [et al.] -- Adjunctive therapy for long-term support of cognitive impairment / Joshua T. Dearborn ... [et al.] -- HIV-1 genetic diversity and its biological significance / Michael M. Thomson -- Opportunistic infections in the brain in developing countries / Marcus Tulius T. Silva and Beatriz Grinsztejn -- Impact of Clade diversity on neuropsychological outcomes / Robert Paul ... [et al.] -- The effects of aging on HIV disease / Robert C. Kalayjian and Lena Al-Harthi -- Neuropsychology of healthy aging / Molly E. Zimmerman and Adam M. Brickman -- Interactions between advanced age and HIV cognitive impairment / Victor Valcour and Aaron M. McMurtray.
  • Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
  • Recognition of pathogens: toll-like receptors /Satoshi Uematsu, Shizuo Akira --Strategies of natural killer (NK) cell recognition and their roles in tumor immunosurveillance /C. Andrew Stewart, Eric Vivier --Recent progress on paired immunoglobulin-like receptors /Hiromi Kubagawa ... [et al.] --Self-nonself recognition through B-cell antigen receptor /Daisuke Kitamura --How do T cells discriminate self from nonself? /Catherine Mazza, Bernard Malissen --Fc receptors /Falk Nimmerjahn, Jeffrey V. Ravetch --Self and nonself recognition by coreceptors on B lymphocytes: regulation of B lymphocytes by CD19, CD21, CD22, and CD72 /Kozo Watanabe, Takeshi Tsubata --Co-receptors in the positive and negative regulation of T-cell immunity /Helga Schneider, Christopher E. Rudd.
  • Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) responsible for 1 in 5 young (under 45) strokes a major cause of early heart attacks responsible for 1 in 5 deep vein thromboses an important cause of migraine.
  • Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.] -- Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.] -- Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.] -- Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.] -- The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.] -- Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].
  • Ibuprofen 2012, Springer
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • IgG4-related disease 2014, Springer
    IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.
  • The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.
  • Immune infertility 2009, Springer
  • Structure and function of the gut mucosal immune system / Reinhard Pabst and Hermann J. Rothkutter -- Functional aspects of the mucosal immune system / Cathryn Nagler-Anderson -- Recent progress in inflammatory bowel disease genetics / Judy H. Cho -- Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation / R. Balfour Sartor -- Experimental models of mucosal inflammation / Warren Strober and Ivan J. Fuss -- Overview of role of the immune system in the pathogenesis of inflammatory bowel disease / Thomas T. MacDonald and Giovanni Monteleone -- The role of the epithelial barrier in inflammatory bowel disease / Edward E.S. Nieuwenhuis and Richard S. Blumberg -- Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease / Francisco Leon ... [et al.] -- Alterations of T lymphocytes in inflammatory bowel diseases / Charles O. Elson, Yingzi Cong and Casey T. Weaver -- The B-cell system in inflammatory bowel disease / Per Brandtzaeg, Hege S. Carlsen and Trond S. Halstensen --Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases / Claudio Fiocchi ... [et al.] -- Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease / Stephan C. Bischoff and Thomas Gebhardt -- Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease / Jonathan Braun and Stephan R. Targan -- The role of probiotics and antibiotics in regulating mucosal inflammation / Rainer Duchmann -- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease / Martin H. Holtmann and Markus F. Neurath.
  • These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
  • Immune response 2006, ScienceDirect
  • Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • Immune-mediated diseases 2007, Springer
  • Acute neuropathies / Bromberg, M.B. -- Chronic neuropathies : chronic inflammatory demyelinating neuropathy and its variants / Ramchandren, S., Lewis, R.A. -- Nonsystemic vasculitic neuropathy : update on diagnosis, classification, pathogenesis, and treatment / Collins, M.P., Periquet-Collins, I. -- Dysimmune neuropathy / Kwan, J.Y. -- Autoimmune autonomic ganglionopathy / Winston, N., Vernino, S. -- Myasthenia gravis with anti-acetylcholine receptor antibodies / Meriggioli, M.N. -- Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis / Muppidi, S., Wolfe, G.I. -- Lambert-Eaton myasthenic syndrome / Pourmand, R. -- Idiopathic inflammatory myopathies / Dimachkie, M.M., Barohn, R.J. -- Stiff person syndrome / Duddy, M.E., Baker, M.R.
  • Immunity and tolerance 2013, Cold Spring Harb Lab Press
    Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.
  • A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle --The Functions of HSP70 in Normal Cells --HSP70 in Damaged Cells --Mechanisms of Activation and Inactivation of HSP70 Synthesis --HSP70 in the Immune Responses --HSP70 in Carcinogenesis --HSP70 in aging --The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • Module 1. Target diseases -- Module 2. The vaccines -- Module 3. The cold chain -- Module 4. Ensuring safe injections -- Module 5. Planning immunization sessions to reach every infant -- Module 6. Holding an immunization session -- Module 7. Monitoring and using your data -- Module 8. Building community support for immunization.
  • Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • Immunochemical protocols. 3rd ed. 2004, Springer Protocols
    Conjugation of antibodies to biotin / James D. Hirsch and Rosaria P. Haugland -- Preparation of colloidal gold probes / David Hughes -- Immunogold probes in light microscopy / David Hughes -- Immunoelectron microscope techniques in plant virus diagnosis / Daphne M. Wright -- Dual-antibody sandwich enzyme-linked immunosorbent assay / William Jordan -- Competitive enzyme-linked immunosorbent assay / William Jordan -- Immunoblotting techniques / Barbara Magi and Sabrina Liberatori -- Epitope mapping / Glenn E. Morris -- Generation and testing of immunoaffinity columns / Weilin L. Shelver -- Immunocapture-polymerase chain reaction / Vincent Mulholland --Immunization strategies for antibody production / Robert Burns -- Synthetic peptides as antigens for antibody production / David C. Hancock and Nicola J. O'Reilly -- Production of polyclonal antibodies in rabbits / David C. Hancock and Nicola J. O'Reilly -- Making hybridomas / Robert Burns -- Growing hybridomas / Gary Entrican and Gareth Young -- Phage display vectors for the in vitro generation of human antibody fragments / Michael Hust and Stefan Dübel -- Purification of antibodies and preparation of antibody fragments / Graham D. Kemp -- Conjugation of antibodies to alkaline phosphatase / G. Brian Wisdom -- Conjugation of antibodies to horseradish peroxidase / G. Brian Wisdom -- Conjugation of antibodies to fluorescein or rhodamine / G. Brian Wisdom --Magnetic cell sorting / Maciej Zborowski and Jeffrey J. Chalmers -- Cell enrichment and immunochemical staining / Oscar R. Lara and Jeffrey J. Chalmers.
  • Immunocytochemistry 2010, Springer
  • HLA and autoimmunity : structural basis of immune recognition / Kai W. Wucherpfennig -- Genomic variation and autoimmune disease / Silke Schmidt and Lisa F. Barcellos -- Endocrine diseases : type I diabetes mellitus / Regine Bergholdt, Michael F. McDermott, and Flemming Pociot -- Endocrine diseases : Graves' and Hashimoto's diseases / Yoshiyuki Ban and Yaron Tomer -- Central and peripheral nervous system diseases / Dorothée Chabas, Isabelle Cournu-Rebeix, and Bertrand Fontaine --Immunogenetics of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus / Allison Porter and J. Lee Nelson -- Gastroenterologic and hepatic diseases / Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux -- Inflammatory myopathies : dermatomyositis, polymyositis, and inclusion body myositis / Renato Mantegazza and Pia Bernasconi -- Hematologic diseases : autoimmune hemolytic anemia and immune thrombocytopenic purpura / Mattias Olsson ... [et al.] -- Genetics of autoimmune myocarditis / Mehmet L. Guler, Davinna Ligons, and Noel R. Rose.
  • Immunoinformatics 2007, Springer Protocols
  • Immunoinformatics 2008, Springer
    IMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
  • pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection.
  • Immunological synapse 2010, Springer
    Insights into function of the immunological synapse from studies with supported planar bilayers / M.L. Dustin -- Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions / J. Doh and M.F. Krummel -- Molecular and cellular dynamics at the early stages of antigen encounter: the B-cell immunological synapse / Y.R. Carrasco -- Inhibitory and regulatory immune synapses / P. Eissmann and D.M. Davis -- The immunological synapse, TCR microclusters, and T cell activation / T. Yokosuka and T. Saito -- Signaling amplification at the immunological synapse / A. Viola, R.L. Contento and B. Molon -- Multiple microclusters: diverse compartments within the immune synapse / S.C. Bunnell -- A conformation-induced oligomerization model for B cell receptor microclustering and signaling / P. Tolar and S.K. Pierce -- Co-receptors and recognition of self at the immunological synapse / N.R. Gascoigne ... [et al.] -- Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses / A. Alcover and M.I. Thoulouze -- Plasticity of immunological synapses / S. Valitutti and L. Dupre -- APC, T cells, and the immune synapse / P. Reichardt, B. Dornbach and M. Gunzer.
  • Immunological tolerance 2007, Springer Protocols
  • The dissection of CD8 T cells during liver-stage infection / U. Krzych and R.J. Schwenk -- Early interactions between blood-stage Plasmodium parasites and the immune system / B.C. Urban, R. Ing, and M.M. Stevenson -- Longevity of the immune response and memory to blood-stage malaria infection / A.H. Achtman ... [et al.] -- Experimental models of cerebral malaria / C. Engwerda ... [et al.] -- Glycosylphosphatidylinositols in malaria pathogenesis and immunity : potential for therapeutic inhibition and vaccination / C.S. Boutlis ... [et al.] -- The immunology and pathogenesis of malaria during pregnancy / J.G. Beeson and P.E. Duffy.
  • Efficiently master key immunology principles! State-of-the-art coverage brings you all of the latest scientific and clinical knowledge, including a new chapter on the use of antibodies and cytokines in immunotherapy. Crystal-clear illustrations, detailed clinical cases, and a user-friendly presentation make immunology remarkably easy to understand. And now, online access via STUDENT CONSULT makes this an even more effective learning resource! Crystal-clear illustrations make immunology remarkably easy to understand. Detailed clinical cases demonstrate real-world applications. Technical boxes point out important scientific advances. End-of-chapter checklists of learning points facilitate review.
  • Immunology for pharmacy 2012, ScienceDirect
    With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
  • Immunology guidebook 2004, ScienceDirect
    Molecules, cells, and tissues of immunity -- Antigens, immunogens, vaccines, and immunization -- Cluster of differentiation (CD) antigens -- The HLA dictionary, 2001 -- Nomenclature for factors of the HLA system, 2002 -- Nomenclature for factors of the dog major histocompatibility system (DLA), 2000 -- Antigen presentation -- B cells, immunoglobulin genes, and immunoglobulin structure -- T cells and the thymus -- Cytokines and chemokines -- The complement system -- Type I, II, III, and IV hypersensitivity -- Microbial immunity -- Immunoregulation, tolerance, and therapeutic immunology -- Immunohematology and transfusion medicine -- Immunological diseases and immunopathology -- Immunodeficiencies : congential and acquired -- Transplantation immunology.
  • Immunology of aging 2014, Springer
    An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
  • 1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • Immunology of pregnancy 2006, Springer
    Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] --Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov --Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
  • The forward genetic dissection of afferent innate immunity / B. Beutler and E.M. Moresco -- Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J / J.F. Marquis and P. Gros -- Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis / G. Orth -- Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases / T. Mashimo, D. Simon-Chazottes and J.L. Guenet -- Cmv1 and natural killer cell responses to murine cytomegalovirus infection / A.A. Scalzo and W.M. Yokoyama -- Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene / I. Kramnik -- Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance / M.W. Appleby and F. Ramsdell -- Fevers, genes, and innate immunity / J.G. Ryan and D.L. Kastner -- Itchy mice: the identification of a new pathway for the development of autoimmunity / L.E. Matesic, N.G. Copeland and N.A. Jenkins -- TIM gene family and their role in atopic diseases / D.T. Umetsu ... [et al.].
  • Immunology. 8th ed. 2013, ClinicalKey
    This textbook teaches the basic and clinical immunology concepts.
  • This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
  • Immunomics reviews v. 2-, 2009-, Springer
  • Immunopharmacology 2008, Springer
  • Microparticles as vaccine delivery systems / Derek T. O'Hagan -- MF59: a safe and potent adjuvant for human use / Audino Podda, Giuseppe Del Giudice, and Derek T. O'Hagan -- Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminium salt / Nathalie Garçon, Marcelle van Mechelen, and Martine Wettendorff -- Virosomes for vaccine delivery / Ian C. Metcalfe and Reinhard Glück -- The ISCOMATRIX adjuvant / Debbie Drane and Martin J. Pearse -- Mineral adjuvants / Erik B. Lindblad --Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin / Jan Holmgren ... [et al.] -- Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant / Richard T. Kenney and Gregory M. Glenn -- T cell adjuvants and novel strategies for their identification / Laurence Van Overvelt and Philippe Moingeon -- Vaccination to treat noninfectious diseases: surveying the opportunities / Stephen W. Martin and Martin F. Bachmann -- Clinical evaluation of adjuvants / Jakub K. Simon and Robert Edelman -- Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines / Elizabeth M. Sutkowski and Marion F. Gruber.Unravelling "the immunologist's dirty little secret" / Virgil E.J.C. Schijns -- Dendritic cells as targets and tools in vaccines / Imerio Capone, Paola Rizza, and Filippo Belardelli -- Host-derived molecules as adjuvants / Tom Barr, Jennifer Carlring, and Andrew W. Heath -- Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants / Achal Pashine, Jeffrey B. Ulmer, and Nicholas M. Valiante -- CpG oligodeoxynucleotides as vaccine adjuvants / Michael J. McCluskie and Risini D. Weeratna -- Toll-like receptor 4 agonists as vaccine adjuvants / David H. Persing ... [et al.] -- Immunomodulatory adjuvants from Quillaja saponaria / Charlotte Read Kensil --
  • Immunosenescence 2013, Springer
    This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.
  • Immunosenescence 2012, Springer
  • Immunotherapy in 2020 2007, Springer
  • Immunotherapy of cancer 2006, Springer
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • Immunotherapy of cancer 2010, Springer Protocols
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
  • v. 1. Principles and methods of immunotoxicology.
  • In silico immunology 2007, Springer
  • Infection and autoimmunity 2004, ScienceDirect
  • The Eye as a model for immune privilege -- Immune privilege of the testis: meaning, mechanisms, and manifestations -- The Role of intrauterine immune privilege in perinatal infectious diseases -- The Liver as an immune-privileged site -- Immune homeostasis of the lung: the role of regulatory NKT cells in asthma -- Immune homeostasis of the gut.
  • Inflammasomes 2011, Springer
  • Ch. 1. Historical reflections on the inflammatory aspects of atherosclerosis -- Ch. 2. Morphology of atherosclerotic lesions -- Ch. 3. Clinical manifestations of atherosclerosis -- Ch. 4. Intra-aortic hematopoietic cells -- Ch. 5. The vascular-associated lymphoid tissue (VALT) -- Ch. 6. Vascular endothelial cells as immunological targets in atherosclerosis -- Ch. 7. The role of adhesion molecules and intimal dendritic cells in the initiation of atherosclerosis -- Ch. 8. Animal models of atherosclerosis -- Ch. 9. A Darwinian-evolutionary concept for atherogenesis: the role of immunity to HSP60 -- Ch. 10. Mediators of vascular inflammation -- Ch. 11. Pentraxins and atherosclerosis -- Ch. 12. Interleukin-33 and atherosclerosis -- Ch. 13. Proteomics of atherosclerosis -- Ch. 14. Adipokines, inflammation, and atherosclerosis -- Ch. 15. Natural antibodies and atherosclerosis -- Ch. 16. NK/NKT cells and atherosclerosis -- Ch. 17. Macrophages and atherosclerosis -- Ch. 18. Host pattern recognition receptors (toll-like receptors, RIG-I-Like receptors, NOD-like receptors) and atherosclerosis -- Ch. 19. Humoral antibodies -- Ch. 20. Adaptive T Cell immunity -- Ch. 21. Immunity to low-density lipoprotein -- Ch. 22. Extracellular matrix and smooth muscle cells -- Ch. 23. The role of infection in atherosclerosis and in plaque stability -- Ch. 24. Inflammatory biomarkers -- Ch. 25. Atherosclerosis in rheumatic diseases -- Ch. 26. Anti-inflammatory therapeutic approaches -- Ch. 27. Vaccination against atherosclerosis -- Ch. 28. Endocrinological aspects of atherosclerosis -- Ch. 29. Imaging of atherosclerosis -- Ch. 30. Future directions of atherosclerosis research and translation into clinical application -- Ch. 31. Controversies and open questions -- Index.
  • Inflammation and cancer 2014, Springer
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
  • Inflammation and cancer v. 1-2, 2009, Springer Protocols
    v. 2, 2009 Springer Protocols
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • Basic aspects of the immunology of neuroinflammation / Wohleb, E.S.; Godbout, J.P. -- Stress and neuroinflammation / Grippo, A.J., Scotti, M.-A.L. -- Role of inflammation in depression : implications for phenomenology, pathophysiology and treatment / Raison, C.L., Miller, A.H. -- Virus infection as a cause of inflammation in psychiatric disorders / Bechter, K. -- Inflammation, neurotoxins and psychiatric disorders / Myint, A.-M. -- Essential fatty acids as potential anti-inflammatory agents in the treatment of affective disorders / Song, C. -- The brain-gut axis : a target for treating stress-related disorders / Scott, L.V., Clarke, G., Dinan, T.G. -- The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs / Arolt, V., Ambrée, O. -- Inflammation as the cause of the metabolic syndrome in depression / Leonard, B.E. -- Glucocorticoids and inflammation : a double-headed sword in depression? / Horowitz, M.A. ... [et al.] -- Co-morbidity between cardiovascular pathology and depression : role of inflammation -- Halaris, A. -- Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome -- Maes, M. -- Peripheral inflammation and cognitive aging -- Lim, A., Krajina, K., Marsland, A.L. -- Inflammation in suicidality : implications for novel treatment options / Janelidze, S., Brundin, L.
  • The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
  • "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • pt. 1. Evolution and epidemiology -- pt. 2. Immunity and vaccine strategies -- pt. 3. Economic and social implications.
  • "There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity. Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty. With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers."--Publisher's website.
  • Innate immunity 2008, Springer Protocols
    ENU mutagenesis in mice / Philippe Georgel ... [et al.] -- Innate immunity genes as candidate genes : searching for relevant natural polymorphisms in databases and assessing family-based association of polymorphisms with human diseases / Pascal Rihet -- KIR locus polymorphisms : genotyping and disease association analysis / Maureen P. Martin and Mary Carrington -- Experimental model for the study of the human immune system : production and monitoring of "human immune system" Rag2-/[gamma]c-/- mice / Nicolas Legrand, Kees Weijer, and Hergen Spits -- Bacterial artificial chromosome transgenesis through pronuclear injection of fertilized mouse oocytes / Kristina Vintersten ... [et al.] -- Bioluminescence imaging to evaluate infections and host response in vivo / Pamela Reilly Contag -- Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes / Susanna Celli, Béatrice Breart, and Philippe Bousso -- Dissection of the antiviral NK cell response by MCMV mutants / Stipan Jonjic ... [et al.] -- Analyzing antibody-Fc-receptor interactions / Falk Nimmerjahn and Jeffrey V. Ravetch -- The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture / David Vremec and Ken Shortman -- Analysis of individual natural killer cell responses / Wayne M. Yokoyama and Sungjin Kim -- Isolation and analysis of human natural killer cell subsets / Guido Ferlazzo -- Innate immune function of eosinophils : from antiparasite to antitumor cells / Fanny Legrand ... [et al.] -- Ex vivo and in vitro primary mast cells / Michel Arock ... [et al.] -- Murine macrophages : a technical approach / Luisa Martinez-Pomares and Siamon Gordon -- Clinical analysis of dendritic cell subsets : the dendritogram / Anne Hosmalin, Miriam Lichtner, and Stéphanie Louis -- Clinical analysis of human natural killer cells / Pascale André and Nicolas Anfossi -- Lentiviral transduction of immune cells / Louise Swainson ... [et al.] -- Axenic mouse model / Antoine Giraud -- In vivo analysis of zebrafish innate immunity / Jean-Pierre Levraud ... [et al.] -- Reverse genetics analysis of antiparasitic responses in the malaria vector, Anopheles gambiae / Stephanie A. Blandin and Elena A. Levashina -- Drosophila immunity : methods for monitoring the activity of toll and Imd signaling pathways / Yves Romeo and Bruno Lemaitre -- Investigating the involvement of host factors involved in intracellular pathogen infection by RNAi in Drosophila cells / Hervé Agaisse -- Models of Caenorhabditis elegans infection by bacterial and fungal pathogens / Jennifer R. Powell and Frederick M. Ausubel -- Genetic analysis of Caenorhabditis elegans innate immunity / Michael Shapira and Man-Wah Tan -- Measuring cell-wall-based defenses and their effect on bacterial growth in Arabidopsis / Min Gab Kim and David Mackey.
  • Innate immunity 2013, Karger
    Microbiota's influence on immunity / Honda, K. ... [et al.] -- Inflammasomes and mucosal immune response / Elinav, E., Henao-Mejia, J., Flavell, R.A. -- Microbial endocrinology : an evolution-based shared mechanism determining microbiota's influence on health and disease / Lyte, M. -- Standing guard : innate lymphoid cells promote immunity and tissue homeostasis at barrier surface / Monticelli, L.A., Artis, D. -- miRNAs that shape the innate immune system : regulation through toll-like receptor signaling / Curtis, A.M., O'Neill, L.A. -- Type 2 diabetes and islet inflammation / Donath, M.Y. -- The innate immune system in Alzheimer's disease / Becker, H., Halle, A. -- Role of inflammasomes in obesity / Dixit, V.D. -- Gut-brain communication in the regulation of system metabolism / Miller, T.D., Pfliger, P.T., and Tschip, M.H. -- Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in drosophila / Loch, G. ... [et al.] -- Dendritics cells orchestrate innate immunity agains bacterial kidney infection / Tittel, A.P. ... [et al.].
  • Evolution of resistance genes in plants /Shunyuan Xiao, Wenming Wang, Xiaohua Yang --Thepath less explored: innate immune reactions in Cnidarians /Thomas C. G. Bosch --Bug versus bug : humoral immune responses in Drosophila melanogaster /Deniz Ertürk-Hasdemir ... [et al.] --Cellular immune responses in Drosophila melanogaster /Adrienne Ivory, Katherine Randle, Louisa Wu --Immune reactions in the vertebrates' closest relatives, the urochordates /Konstantin Khalturin, Ulrich Kürn, Thomas C. G. Bosch --Innate immune system of the zebrafish, Danio rerio /Con Sullivan, Carol H. Kim --Toll-like receptors in the mammalian innate immune system /Andrei E. Medvedev, Stefanie N. Vogel --NLRs : a cytosolic armory of microbial sensors linked to human diseases /Mathias Chamaillard --Antimicrobial peptides as first-line effector molecules of the human innate immune system /Regine Gläser, Jürgen Harder, Jens-Michael Schröder --Thecomplement system in innate immunity /K. R. Mayilyan ... [et al.].
  • Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may
  • Integrins 2007, ScienceDirect
  • Interferon 2007, Springer
  • Interferon methods and protocols 2005, Springer Protocols
  • " This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
  • Intradermal immunization 2012, Springer
    Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies -- Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design -- Delivery systems for intradermal vaccination -- Targeting skin dendritic cells to improve intradermal vaccination -- Intradermal rabies vaccination : the evolution and future of pre- and post-exposure prophylaxis -- Intradermal vaccination to protect against yellow fever and influenza -- The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma -- DNA vaccines and intradermal vaccination by DNA tattooing
  • Intrinsic immunity 2013, Springer
    The APOBEC3 Family of Retroelement Restriction Factors /Eric W. Refsland, Reuben S. Harris --Inhibition of Retroviral Replication by Members of the TRIM Protein Family /Adam J. Fletcher, Greg J. Towers --The Antiviral Activities of Tetherin /Stuart J. D. Neil --Restriction of Retroviral Infection of Macrophages /Mark Sharkey --Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors /Welkin E. Johnson --RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants /György Szittya, József Burgyán --RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates /Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino --Roles of MicroRNAs in the Life Cycles of Mammalian Viruses /Eva Gottwein --Interplay Between DNA Tumor Viruses and the Host DNA Damage Response /Karyn McFadden, Micah A. Luftig.
  • Historical antecedents -- Immune system basics -- Endocrine-immune modulation -- Neuroimmune modulation -- Stress, contextual change, and disease -- Psychosocial stress: neuroendocrine and immune effects -- Infection, allergy, and psychosocial stress -- Cancer, autoimmunity, and psychosocial stress -- Immune activity and psychopathology -- Immune function enhancement -- Integration and implications.
  • Killer lymphocytes 2005, Springer
  • KIR gene cluster 2003, NCBI Bookshelf
  • Köhler's invention 2005, Springer
  • Lymph node cytopathology 2011, Springer
    Introduction -- Overview of ancillary methods in lymph node FNA diagnosis -- Lymphadenopathy: anatomic and clinical clues to fine needle aspiration diagnosis -- Cytology of normal/reactive lymph nodes -- Overall assessment of the aspirate: diagnostic clues -- Overview of the algorithmic pattern-based approach to lymph node FNA -- The polymorphous lymphoid cell pattern -- The monotonous small-cell pattern -- The monotonous intermediate-sized cell pattern -- The monotonous large cell pattern -- The pleomorphic cell pattern -- Infectious and noninfectious lympadenitis -- Unusual neoplastic and nonneoplastic conditions of lymph nodes -- Pitfalls and limitations of FNA of lymph nodes.
  • Lymphedema 2008, Springer
  • Primary Lymphedema as a Truncular Lymphatic Malformation -- Primary Lymphedema and Klippel-Trénaunay Syndrome -- Special Issues in Pediatric Primary Lymphedema -- Medical Management -- Surgical Management -- Epidemiology -- Etiology and Pathophysiology -- Clinical Overview-Diagnosis and Management -- Genetic Prospects for Lymphedema Management -- Breast Cancer -- Lower Extremity Cancers -- Radiation Complications -- Pathophysiology of Phlebolymphedema and a Physiologic Approach to Chronic Veno-lymphatic Insufficiency' -- Diagnosis and Management of Primary Phlebolymphedema -- Diagnosis and Management of Secondary Phlebolymphedema -- Management of Phlebolymphedema Ulcers -- Lymphedema Management by the Therapists -- Education of the Patient -- Patient/Family Advocacy -- Reimbursement of CDT-based Care -- General Considerations -- Etiology and Classification of Lymphatic Disorders -- Hereditary and Familial Lymphedema -- Embryology of the Lymphatic System and Lymphangiogenesis -- Anatomy of the Lymphatic System and Its Disorders -- Physiology, Pathophysiology, and Lymphodynamics: General Overview -- Lymphedema -- Physiology, Biology, and Lymph Biochemistry -- Physiology - Lymph Flow -- Pathology and Histochemistry -- Clinical Diagnosis: General Overview -- Clinical Staging -- Combined Clinical and Laboratory (Lymphoscintigraphic) Staging -- Early Diagnosis in Latent Phase -- Review of National and International Consensuses on Chronic Lymphedema -- Differential Diagnosis - General Considerations -- Differential Diagnosis - Lipedema -- Laboratory/Imaging Diagnosis: General Guidelines -- Radionuclide Lymphoscintigraphy -- Duplex Ultrasonography -- Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease -- Oil Contrast Lymphangiography -- Fluorescent Microlymphangiography -- Alternative Assessment and Measurement Tools -- Infection -- Physiological Principles of Physiotherapy -- Complete Decongestive Therapy -- Manual Lymph Drainage (Földi Method) -- Manual Lymph Drainage (Leduc Method) -- Compression Therapy -- Intermittent Pneumatic Compression Therapy -- Other Contemporary Treatment Modalities -- Medical Treatment -- Lower Limb Lymphedema -- Upper Limb Lymphedema -- Head and Neck Lymphedema -- Genital Lymphedema -- Psychological Aspect: Compliance and Quality of Life -- General Overview - Historical Background -- General Principles and Indications -- Lymphatic-Venous Derivative and Reconstructive Microsurgery -- Lymphatic-Lymphatic Reconstructive Microsurgery -- Lymph Node-Venous Microvascular Reconstructive Surgery: Filariasis Lymphedema -- Lymph Nodes Transfer Microvascular Reconstructive Surgery -- Current Dilemmas and Controversy -- Prospects for Lymphatic Reconstructive Surgery -- Historical Background - General Overview -- General Principles -- Contemporary Indications and Controversies -- Surgical Treatment of Postmastectomy Lymphedema - Liposuction -- Epilogue.
  • "This second edition provides guidance on all aspects of how to make and use antibodies for research, and commercial and industrial applications. All chapters are revised, updated, or expanded. New material in the book includes western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present descriptions of basic methods for making and using antibodies and describe basic laboratory techniques in detail. Each chapter includes introductory material, allowing for a better understanding of each concept. Practical examples are also included"--Provided by publisher.
  • pt. 1. Malaria parasites and disease -- Structure and life cycle / H. Fujioka -- Malaria parasites and the Anopheles mosquito /G. Dimopoulos -- Malaria: pathogenicity and disease / M. English -- pt. 2. Malaria antigens -- Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein / P. Sinnis -- Immune responses to liver-stage parasites: implications for vaccine development / M.R. Hollingdale -- Merozoite antigens involved in invasion / K. Berzins -- Asexual blood stages of malaria antigens: cytoadherence / D.I. Baruch -- Rosetting and autoagglutination in Plasmodium falciparum / V. Fernandez -- Sexual and sporogonic stage antigens / R.W. Sauerwein -- pt. 3. Malaria infection: immunity and regulation -- Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology / J. Langhorne -- Malaria and the immune system in humans / P. Perlmann -- Genetic regulation of malaria infection in humans / M. Troye-Blomberg -- pt. 4. Malaria vaccines -- Pre-erythrocytic malaria vaccines to prevent Plasmodium flaciparum malaria / W.R. Ballou -- Vaccines against asexual stage malaria parasites / S. Kumar -- Transmission-blocking vaccines / D.C. Kaslow -- Nucleic acid vaccines against malaria / D.L. Doolan -- Antidisease vaccines / L. Schofield -- Adjuvants and malaria vaccine development / L. Xiao -- Malaria vaccine trials / B. Greenwood.
  • Managing allergens in food 2007, CRCnetBASE
    pt. 1. What are food allergens and allergies? -- pt. 2. Allergens in foods - from raw to processed foods -- pt. 3. Assessing allergic risks and practical management of allergens in food.
  • Print Material
    Introduction to the immune system / Lori Broderick, Taylor A. Doherty, and David Broide -- Immediate hypersensitivity : approach to diagnosis / Sarbjit S. Saini and Nkiruka Erekosima -- Aeroallergens and environmental factors / William Neaville, Robert Ausdenmoore, and Robert K. Bush -- Rhinitis / Candace Bouler Anz and Mark S. Dykewicz -- Sinusitis, nasal polyps, and otitis media / Ricardo A. Tan and Jonathan Corren -- Immunotherapy for inhalant allergens / Harold S. Nelson -- Allergic and immunologic disorders of the eye / Leonard Bielory -- Asthma diagnosis / Stephen C. Lazarus -- Asthma treatment / Joel M. Hartman ... [et al.] -- Immunologic diseases of the lung / Shefalee Amin, Michelle Zeidler, and Eric Kleerup -- Atopic dermatitis and contact dermatitis / Mark Boguniewicz, Marcella Aquino, and Luz Fonacier -- Urticaria and angioedema / Jeffrey R. Stokes and Mark H. Moss -- Anaphylaxis / Phil Lieberman and Debendra Pattanaik -- Insect allergy / David B. K. Golden -- Drug allergy / David A. Khan -- Allergic and non-allergic reactions to food / Stephen R. Boden and A. Wesley Burks -- Eosinophilic gastrointestinal disorders / Terri F. Brown-Whitehorn ... [et al.] -- Primary immunodeficiency diseases / Shradha Agarwal and Charlotte Cunningham-Rundles -- Approach to the patient with recurrent infections / Zuhair K. Ballas -- Diagnostic immunology / Thomas A. Fleisher, Joao Bosco Oliveira, and Jack J. H. Bleesing -- Adverse responses to vaccines / John M. Kelso -- Complementary medicine in allergy and immunology / Timothy Ryan Mainardi and Leonard Bielory -- Building related illness / Jessica Savage and Robert A. Wood.
  • Mass vaccination 2006, Springer
    Mass Vaccination: When and Why / D. L. Heymann and R. B. Aylward -- Mass Vaccination and Surveillance/Containment in the Eradication of Smallpox / J. M. Lane -- Mass Immunization Programs: Principles and Standards / J. D. Grabenstein and R. L. Nevin -- Immunization Campaigns in the UK / K. Noakes and D. Salisbury -- Diphtheria / C. R. Vitek -- Universal Mass Vaccination against Hepatitis A / F. E. André -- Mass Vaccination against Hepatitis B: the French Example / F. Denis and D. Levy-Bruhl -- Mass Vaccination for Annual and Pandemic Influenza / B. Schwartz and P. Wortley -- Is Global Measles Eradication Feasible? / C. A. de Quadros -- Measles Aerosol Vaccination / J. L. Valdespino-Gómez, M de Lourdes Garcia-Garcia, J. Fernandez-de-Castro, A. M. Henao-Restrepo, J. Bennett, and J. Sepulveda-Amor -- Mass Vaccination Campaigns for Polio Eradication: an Essential Strategy for Success / R. W. Sutter and C. Maher -- Rubella Mass Campaigns / S. Reef -- Mass Vaccination to Control Epidemic and Endemic Typhoid Fever / M. M. Levine -- Mass Vaccination: Solutions in the Skin / G. M. Glenn and R. T. Kenney.
  • Mast cells and tumours 2011, Springer
    Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
  • Preface -- Thymocyte development -- A review of mathematical models for T cell receptor triggering and antigen discrimination -- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation -- T cell activation and function: role of signal strength -- The cyton model for lymphocyte proliferation and differentiation -- Modeling itravital two-photon data of lymphocyte migration and interaction -- Modeling lymphocyte dynamics in vivo -- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery -- Multivariate competition processes: a model for two competing T cell clonotypes -- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation -- Dendritic cell migration in the intestinal tract -- Reassessing germinal center reaction concepts -- B cell strategies of Ag recognition in a stratified immune system -- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells -- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells -- A Physicist{u2019}s approach to immunology -- Timescales of the adaptive immune response -- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection -- Viral immunity and persistence -- Index.
  • Making it to the synapse : measles virus spread in and among neurons / V.A. Young and G.F. Rall -- Modeling subacute sclerosing panencephalitis in a transgenic mouse system : uncoding pathogenesis of disease and illuminating components of immune control / M.B.A. Oldstone -- Measles studies in the macaque model / R.L. de Swart -- Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines / P. Pillet, N. Svitek and V. von Messling -- Current animal models : cotton rat animal model / S. Niewiesk -- Current animal models : transgenic animal models for the study of measles pathogenesis / C.I. Sellin and B. Horvat -- Molecular epidemiology of measles virus / P.A. Rota, D.A. Featherstone, and W.J. Bellini -- Human immunology of measles virus infections / D. Naniche -- Measles control and the prospect of eradication / W.J. Moss -- Measles : old vaccines, new vaccines / D.E. Griffin and C.-H. Pan -- Measles virus for cancer therapy / S.J. Russell and K.W. Peng -- Measles virus-induced immunosuppression / S. Schneider-Schaulies and J. Schneider-Schaulies -- Hostile communication of measles virus with host innate immunity and dendritic cells / B. Hahm.
  • Measuring immunity 2005, ScienceDirect
    MHC class I -- MHC class II -- Cytokine receptor heterogeneity -- Genetic diversity at human cytokine loci in health and disease -- Signaling molecules affecting immune response -- Toll-like receptors in innate immunity -- DNA sequence-specific transcription factors -- Genetic diversity in NK and NKT cells -- Handling sera and obtaining fluid from different compartments -- Acute-phase proteins and inflammation -- Complement in health and disease -- Immunoglobulin titers and immunoglobulin subtypes -- Human antiglobulin responses -- Rheumatoid factors -- Autoantibodies -- Antibody affinity using fluorescence -- SLE-associated tests -- Multiplexed serum assays -- Handling and storage of cells and sera: practical considerations -- Phenotypic and functional measurements on circulating immune cells and their subsets -- Natural killer cells -- Tetramer analysis -- Peripheral blood naive and memory B cells -- Dendritic cells -- Monocytes and macrophages -- Tumor cells -- Regulatory T cells -- Intracellular cytokine assays -- Cytolytic assays --Mixed leukocyte reactions -- Antigen/mitogen-stimulated lymphocyte proliferation -- Monitoring cell death -- Cytokine enzyme linked immunosorbent spot (ELISPOT) assay -- Testing natural killer cells -- Delayed type hypersensitivity responses -- Rebuck windows: granulocyte function -- The vascular and coagulation systems -- Sentinel node assays -- Imaging inflammation -- Cancer - solid tumors -- Cancer - hematologic disorders -- Autoimmunity - rheumatoid arthritis -- Autoimmunity - type 1 diabetes -- Autoimmunity - systemic lupus erythematosus -- Autoimmunity - multiple sclerosis -- Autoimmunity - inflammatory bowel disease -- Autoimmunity - endocrine -- Autoimmunity - vasculitis -- Transplantation -- Viral responses - HIV-1 -- Viral responses - epstein-barr virus -- Viral responses - hepatitis -- Dermatology -- Arteriosclerosis -- Primary immunodeficiencies -- Asthma and allergy -- Serum proteomic profiling and analysis -- Imaging cytometry -- Cancer biometrics -- Genomics and microarrays -- Image informatics.
  • Medical immunology. 5th ed. 2001, CRCnetBASE
  • "This new edition presents information on how melatonin is synthesized and produced in the body as well as how this hormone affects several diseases. The book heavily focuses on prevention as well as treatment of various human disease states including behavior disorders, mental disorders, breast cancer, bone health, and gastrointestinal diseases. It covers the role of melatonin in the prevention of oxidative stress, mutagenesis, sun damage, ocular health, gut motility, and detoxification. It also presents mechanisms of melatonin action in humans including cell modulation, signaling mechanisms, protective effects, and melatonin receptors as well as its role as an antioxidant"--Provided by publisher.
  • Memory T cells 2010, Springer
    Memory TH1/TH2 cell generation controlled by Schnurri-2 / Toshinori Nakayama and Motoko Y. Kimura -- Transcriptional regulation during CD8 T-cell immune responses / Ivana Munitic ... [et al.] -- The role of interleukin-2 in memory CD8 cell differentiation / Onur Boyman, Jae-Ho Cho and Jonathan Sprent -- The role of inflammation in the generation and maintenance of memory T cells / Noah S. Butler and John T. Harty -- The role of OX40 (CD134) in T-cell memory generation / Andrew D. Weinberg -- The role of precursor frequency in the differentiation of memory T cells : memory by numbers / Amanda L. Marzo, Ryan T. Sowell and Bernadette Scott -- CD8 T-cell memory differentiation during acute and chronic viral infections / Vandana Kalia, Surojit Sarkar and Rafi Ahmed -- Longevity of T-cell memory following acute viral infection / Joshua M. Walker and Mark K. Slifka -- Principles of memory CD8 T-cells generation in relation to protective immunity / Maurizio Zanetti, Paola Castiglioni and Elizabeth Ingulli --Memory T cells in rhesus macaques / Monica Vaccari and Genoveffa Franchini -- Memory T-cell subsets in parasitic infections / Sara Colpitts and Phillip Scott -- Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responses / Kory L. Alderson and William J. Murphy -- Memory T-cell responses and survival in human cancer : remember to stay alive / Matthieu Camus and Jérôme Galon -- Analysis of vaccine-induced T cells in humans with cancer / Stefanie L. Slezak ... [et al.] -- Memory T-cell homeostasis and senescence during aging / Sian M. Henson and Arne N. Akbar.
  • Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- "ABC" of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. ... [et al.] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. ... [et al.] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. ... [et al.] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A.
  • MicroRNAs and the immune system 2010, Springer Protocols
    A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation -- Normalization of microRNA quantitative RT-PCR data in reduced scale experimental designs -- MicroRNA detection in bone marrow cells by LNA-FISH -- Measuring microRNA expression in size-limited facs-sorted and microdissected samples -- MicroRNA cloning from cells of the immune system -- High-throughput profiling in the hematopoietic system -- Construction of small RNA cDNA libraries for deep sequencing -- MicroRNA-profiling in formalin-fixed paraffin-embedded specimens -- Expression of miRNAs in lymphocytes : A review -- Mouse models for miRNA expression: The ROSA26 locus -- Regulation of monocytopoiesis by microRNAs -- MicroRNA activity in B lymphocytes -- Isolation and characterization of microRNAs of human mature erythrocytes -- Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors -- Monitoring microRNA activity and validating microRNA targets by reporter-based approaches -- Lentivirus-mediated antagomir expression -- Solution structure of miRNA:mRNA complex -- MiRNA editing -- Computational prediction of microRNA targets -- Large-scale integration of microRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems -- Identification and validation of the cellular targets of virus-encoded microRNAs.
  • Print Material
  • Fulltext ClinicalKey
  • Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation / K.L. Medina, H. Singh -- Helix-loop-helix proteins in lymphocyte lineage determination / B.L. Kee -- Ikaros-family proteins : in search of molecular functions during lymphocyte development / B.S. Cobb, S.T. Smale -- Biochemistry of V(D)J recombination / D.G. Schatz, E. Spanopoulou -- The pre-B cell receptor in B cell development : recent advances, persistent questions and conserved mechanisms / M.R. Clark ... [et al.] -- Transcriptional control of B cell activation / L.M. Corcoran -- Expression of MHC II genes / G. Drozina ... [et al.] -- Class switch recombination : an emerging mechanism / A.L. Kenter -- Blimp-1 ; Immunoglobulin secretion and the switch to plasma cells / R. Schiammas, M.M. Davis -- Wnt signaling in lymphopoiesis / A. Timm, R. Grosschedl.
  • This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • Molecular autoimmunity 2005, Springer
  • Molecular biology of B cells 2004, ScienceDirect
  • Part 1. Introduction to Glyco-Experiences -- Serendipity in Scientific Discoveries: Some Examples in Glycosciences / Yuan-Chuan Lee -- My 30-Year Devotion to the N-Linked Oligosaccharide Structures / Noriko Takahashi -- Part 2. Blood Group ABH/Le-related Antigens -- Human Blood Group ABH/Ii, Lea,b,x,y, and Sialyl Lea,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions / Hui-Li Chen -- A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes / Su-Chen Li, Kimberly M. Anderson and Yu-Teh Li -- Part 3. Lectins -- Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin-Glycan Interactions / Albert M. Wu, Jia-Haw Liu, Tanuja Singh and Zhangung Yang -- Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes / Albert M. Wu, Tanuja Singh, Jia-Hau Liu, Sabine André and Martin Lensch, et al. -- Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens / Pierre Rougé, Willy J. Peumans, Els J. M. Van Damme, Annick Barre and Tanuja Singh, et al. -- The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins / Nechama Gilboa-Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Batya Lerrer and Anne Imberty, et al. -- On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder -- Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose, and Ethanol / Nachman C. Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Itschak Axelrad and Nechama Gilboa-Garber -- Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins / Jared Q. Gerlach, Michelle Kilcoyne, Seron Eaton, Veer Bhavanandan and Lokesh Joshi -- Novel Concepts About the Role of Lectins in the Plant Cell / Els J. M. Van Dammes, Elke Fouquaert, Nausicaä Lannoo, Gianni Vandenborre and Dieter Schouppe, et al. --Part 4. Structures and Functions of Glycolipids -- Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization / Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani and Manuela Valsecchi, et al. -- 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells / Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal and Sarmila Chandra, et al. -- GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells / Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang and Toshinori Sato, et al. -- Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies / Robert K. Yu, Toshio Ariga, Seigo Usuki and Ken-ichi Kaida -- Structure and Function of Glycolipids in Thermophilic Bacteria / Feng-Ling Yang, Yu-Liang Yang and Shih-Hsiung Wu -- Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai -- Part 5. Structures and Functions of Complex Carbohydrates -- Roles for N- and O-Glycans in Early Mouse Development / Suzannah A. Williams and Pamela Stanley -- Glycobiology in the Field of Gerontology (Glycogerontology) / Akira Kobata -- Galectins in Regulation of Apoptosis / Fu-Tong Liu, Ri-Yao Yang, Jun Saegusa, Huan-Yuan Chen and Daniel K. Hsu -- Avian and Human Influenza Virus Receptors and Their Distribution / Yasuo Suzuki -- Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis / Dipak K. Banerjee, Caroline M. Oliveira, José J. Tavárez, Viswa N. Katiyar and Subiman Saha, et al. -- Mucin O-Glycan Branching Enzymes: Structure, Function, and Gene Regulation / Pi-Wan Cheng and Prakash Radhakrishnan -- Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza -- Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis / Pierre Rougé, Wim Nerinckx, Clare Gough, Jean-Jacques Bono and Annick Barre -- Part 6. Glycoimmunology -- O-Acetylated Sialic Acids and Their Role in Immune Defense / Roland Schauer, G. Vinayaga Srinivasan, Dirk Wipfler, Bernhard Kniep and Reinhard Schwartz-Albiez -- Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes / Reiji Kannagi, Katsuyuki Ohmori, Guo-Yun Chen, Keiko Miyazaki and Mineko Izawa, et al. -- Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum / Elwira Lisowska and Maria Duk -- Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation / Pei-Weng Wang and Tai-Long Pan -- Part 7. Glycobiology of Cancer -- Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos and Susan N. Thomas -- Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l-PPMP and Cisplatin / Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks and James R. Johnson, et al. -- Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor-Host Interactions / Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli and Valentina Nocco, et al. -- Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance / Sadako Inoue, Ken Kitajima, Chihiro Sato and Shinji Go -- Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zou and Harold J. Jennings -- Part 8. Glyco Applications -- Synthesis of Hemagglutinin-Binding Trisaccharides / Cheng-Chung Wang, Suvarn S. Kulkarni, Medel Manuel L. Zulueta and Shang-Cheng Hung -- Fabrication and Applications of Glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak and Chun-Cheng Lin -- Glycan Arrays to Decipher the Specificity of Plant Lectins / Els J. M. Van Damme, David F. Smith, Richard Cummings and Willy J. Peumans -- Targeting C-Type Lectin for the Treatment of Flavivirus Infections / Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu and Shie-Liang Hsieh.
  • Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • Functional morphology of the gastrointestinal tract /L. Shen --Vibrio cholerae interactions with the gastrointestinal tract: Lessons from animal studies /J.M. Ritchie and M.K. Waldor --Interaction of Yersinia with the gut: Mechanisms of pathogenesis and immune evasion /P. Dube --Molecular mechanisms of Salmonella virulence and host resistance /Y. Valdez, R.B.R. Ferreira and B.B. Finlay --Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori /tW. Fischer, S. Prassl and R. Haas --Listeria as an enteroinvasive gastrointestinal pathogen /S.B. Barbuddhe and T. Chakraborty --Molecular mechanisms of Campylobacter infection /J.P.M. Putten ... [et al.] --Shigella infection of intestinal epithelium and circumvention of the host innate defense system /H. Ashida ... [et al.].
  • Molecular mimicry 2005, Springer
    Molecular mimicry, microbial infection, and autoimmune disease : evolution of the concept / M.B.A. Oldstone -- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination / K.W. Wucherpfennig -- A virus-induced molecular mimicry model of multiple sclerosis / J.K. Olson, A.M. Ercolini, and S.D. Miller -- Suppression of autoimmunity via microbial mimics of altered peptide ligands / L. Steinman, P.J. Utz, and W.H. Robinson -- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry / M.B.A. Oldstone -- Trypanosoma cruzi-induced molecular mimicry and Chagas' disease / N. Gironès, H. Cuervo, and M. Fresno -- HTLV-1 induced molecular mimicry in neurological disease / S.M. Lee ... [et al.] -- Molecular mimicry : anti-DNA antibodies bind microbial and nonnucleic acid self-antigens / J.S. Rice ... [et al.] -- Chlamydia and antigenic mimicry / K. Bachmaier and J.M. Penninger.
  • Monoclonal antibodies 2007., Springer Protocols
  • Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • Mucosal immune defense 2007, Springer
  • The role of mucosal immunity in protection against viral diseases / Vandana Madkan, Karan Sra, and Stephen K. Tyring -- Anogenital mucosal immunology and virology / Anthony Simmons -- Gastrointestinal mucosal immunology / David A. Bland, Carlos A. Barrera, and Victor E. Reyes -- Virology of the gastrointestinal tract / Richard L. Ward ... [et al.] -- Oral manifestations of viral diseases / Denis P. Lynch -- Common respiratory viruses and pulmonary mucosal immunology / David B. Huang -- Ophthalmic manifestations of viral diseases / Steven Yeh and Mitchell P. Weikert.
  • In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • Mucosal immunology. 3rd ed. 2005, ScienceDirect
  • Mucosal vaccines 2012, Springer
    Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
  • Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage.
  • v. 2, 2009 Springer
    v. 3, 2010 Springer
    v. 1. Frontiers in research -- v. 2. Impact on Global Health -- v. 3. Intramural research.
  • Natural immunity 2005, ScienceDirect
  • Natural killer cells 2010, Springer
  • Natural killer T cells 2012, Springer
    Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi ... [et al.] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes ... [et al.] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders ... [et al.] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
  • Naturally occurring IgM antibodies to oxidation-specific epitopes / Christoph J. Binder -- Naturally occurring autoantibodies to apoptotic cells / Keith B. Elkon and Gregg J. Silverman -- Naturally occurring antibodies directed against carbohydrate tumor antigens / Reinhard Schwartz-Albiez -- Naturally occurring antibodies as therapeutics for neurologic disease : can human monoclonal IgMs replace the limited resource IVIG? / Arthur E. Warrington ... [et al.] -- Nature and nurture of catalytic antibodies / Sudhir Paul ... [et al.] -- Naturally occurring autoantibodies in mediating clearance of senescent red blood cells / Hans U. Lutz -- Naturally occurring autoantibodies against ss-amyloid / Jan-Philipp Bach and Richard Dodel -- Multi-faceted role of naturally occurring autoantibodies in fighting pathogens / Hicham Bouhlal and Srini Kaveri -- Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses / Claus H. Nielsen and Klaus Bendtzen -- Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies / Jaap Kwekkeboom -- Control of B cells expressing naturally occurring autoantibodies / Jean Louis Pasquali and Thierry Martin -- Granulocyte death regulation by naturally occurring autoantibodies / Stephan Von Gunten and Hans-Uwe Simon -- Naturally occurring autoantibodies mediate ischemia/reperfusion-induced tissue injury / Sherry D. Fleming -- How immune complexes from certain IgG NAbs and any F(ab')2 can mediate excessive complement activation / Hans U. Lutz -- The natural autoantibody repertoire in newborns and adults : a current overview / Asaf Madi ... [et al.] -- Antibody polyspecificity : what does it matter? / Jordan D. Dimitrov, Anastas D. Pashov, Tchavdar L. Vassilev -- Positive and negative selection of natural autoreactive B cells / Richard R. Hardy and Kyoko Hayakawa -- Naturally occurring antibodies/autoantibodies in polyclonal immunoglobulin concentrates / Peter J. Späth and Hans U. Lutz.
  • TIM-3 and its regulatory role in immune responses / Chen Zhu, Ana C. Anderson and Vijay K. Kuchroo -- Role of PD-1 in regulating T-cell immunity / Hyun-Tak Jin, Rafi Ahmed and Taku Okazaki -- The role of IL-10 in regulating immunity to persistent viral infections / Elizabeth B. Wilson and David G. Brooks -- Inhibitory Ly49 receptors on mouse natural killer cells / Mark T. Orr and Lewis L. Lanier -- Immunoregulatory roles for Fc receptor-like molecules / Götz R.A. Ehrhardt and Max D. Cooper -- Fc[gamma]Rs in health and disease / Falk Nimmerjahn and Jeffrey V. Ravetch -- TGF-[beta] function in immune suppression / Akihiko Yoshimura and Go Muto.
  • Neonatal immunity 2005, Springer
    Structure and function of immune system in vertebrates -- Ontogeny and development of cells mediating innate and adaptive immunity -- Phenotypic characteristics of neonatal B cells -- Molecular characteristics of neonatal B cell repertoire -- Genetically programmed temporal ordered activation of neonatal B cell clones -- Antibody response in fetus and newborn -- Effect of maternal antibodies on neonatal B cell response -- Neonatal autoimmune diseases caused by maternal pathogenic autoantibodies -- Phenotypic characteristics of neonatal T cells -- Expression of MHC molecules in neonates -- Neonatal cytokine network -- Cell-mediated immune responses in neonates -- Fetal and neonatal tolerance -- Development of efficient prophylactic vaccines and theracines for newborns and infants .
  • Nerve-driven immunity 2012, Springer
    Dopamine in the Immune System: Dopamine Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Immune and Neuropsychiatric Diseases --Nerve Driven Immunity: Noradrenaline and Adrenaline --Acetylcholine and Cholinergic Modulation of Immune Responses --Glutamate in the Immune System: Glutamate Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Disease --GABA Is an Effective Immunomodulatory Molecule in the Brain and in the Periphery --The Effects of Opioids on Immune Cells, Functions and Diseases --The Effects of Somatostatin on Immune Cells, Functions and Diseases --Neuropeptide Y: The Story, the Players, the Outcomes --Vasoactive Intestinal Peptide: Immune Mediator and Potential Therapeutic Agent --Nerve-Driven Immunity: The Effects of Neurotransmitters on Immune Cells, Functions and Disease --CGRP --The Effects of Cannabinoids on Immune Cells, Responses and Diseases.
  • Network collective 2008, Springer
  • Neuroimmunology of sleep 2007, Springer
  • Systemic lupus erythematosus -- Antiphospholipid syndrome -- Rheumatoid arthritis -- Inflammatory muscle diseases -- Vasculitides -- Other conditions with neurologic involvement.
  • New foundation of biology 2001, ScienceDirect
  • Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis /Mateusz S. Wietecha, Wendy L. Cerny, Luisa A. DiPietro --Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals /Aiko Kawasumi, Natsume Sagawa, Shinichi Hayashi --Cellular Plasticity During Vertebrate Appendage Regeneration /James R. Monaghan, Malcolm Maden --Cell Signaling Pathways in Vertebrate Lens Regeneration /Jonathan J. Henry, Alvin G. Thomas, Paul W. Hamilton --Regenerative Medicine: Challenges and Perspectives for Successful Therapies /S. Viswanathan, C. Joshi --Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects /Jo Ann Cameron, Derek J. Milner, Jung Seok Lee --Muscle Repair and Regeneration: Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration /Derek J. Milner, Jo Ann Cameron --Neural Regeneration /Melissa M. Steward, Akshayalakshmi Sridhar --Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System /Günther K. H. Zupanc, Ruxandra F. Sîrbulescu --Epigenetics and Regeneration /Nobuyasu Maki, Hironobu Kimura --Cell Cycle Regulation and Regeneration /Ellen Heber-Katz, Yong Zhang, Khamila Bedelbaeva.
  • Allergy in evolution / Platts-Mills, T.A.E. -- Climate change, environment and allergy / Behrendt, H., Ring, J. -- The hygiene hypothesis does not apply to atopic eczema in childhood / Cramer, C. ... [et al.] -- Molecular genetics of atopic eczema / Ring, J., Mohrenschlager, M., Weidinger, S. -- Mechanisms of immune tolerance to allergens / Fujita, H. ... [et al.] -- TH17 and TH22 in skin allergy / Cavani, A., Pennino, D., Eyerich, K. -- IL-25 induces both inflammation and skin barrier dysfunction in atopic dermatitis / Deleuran, M. ... [et al.] -- Angiogenesis, lymphangiogenesis and atopic dermatitis / Genovese, A. ... [et al.] -- What can dogs bring to atopic dermatitis research? / Olivry, T. -- Can microbial superantigens influence atopic dermatitis flares? / Alomar, A. -- Inflammation-induced alterations in the skin barrier function: implications in atopic dermatitis / Vestergaard, C. ... [et al.] -- Itch and eczema / Darsow, U. -- Eczema herpeticum / Wollenberg, A. -- Bone mineral density in patients with atopic dermatitis / Haeck, I. -- Immunosuppressive effect of prolactin-induced protein / Sugiura, S. ... [et al.] -- Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study / Keck, L.E. ... [et al.] -- New strategies for dealing with staphylococcus aureus colonization and the emerging methicillin-resistant staphylococcus aureus epidemic in atopic dermatitis / Boguniewicz, M. -- Anti-IL-4 as a new strategy in allergy / Schmidt-Weber, C.B. -- New drug targets in atopic dermatitis / Simon, D., Simon, H.U. -- Latest approaches to treating atopic dermatitis / Paller, A.S.
  • Understanding the logic of I[kappa]B:NF-[kappa]B regulation in structural terms / Tom Huxford, Alexander Hoffmann and Gourisankar Ghosh -- NF-[kappa]B/Rel proteins and the humoral immune responses of Drosophila melanogaster / Sandhya Ganesan ... [et al.] -- Specialized chromatin patterns in the control of inflammatory gene expression / Gioacchino Natoli -- IKK regulation and human genetics / Giles Courtois and Alain Israel -- Control of NF-[kappa]B activity by proteolysis / Veronique Baud and Emmanuel Derudder -- NF-[kappa]B and Innate immunity / Anurupa Dev ... [et al.] -- NF-[kappa]B and mucosal homeostasis / Lars Eckmann and Andrew S. Neish -- IKK- and NF-[kappa]B-mediated functions in carcinogenesis / Melek C. Arkan and Florian R. Greten -- Macrophages and NF-[kappa]B in cancer / Toby Lawrence -- NF-[kappa]B in liver cancer : The plot thickens / Shlomi Finkin and Eli Pikarsky -- NF-[kappa]B as a target for oncogenic viruses / Shao-Cong Sun and Ethel Cesarman -- Inhibition of NF-[kappa]B signaling as a strategy in disease therapy / Thomas D. Gilmore and Michael R. Garbati.
  • Clinical development of oligodeoxynucleotide TLR9 agonists / by Julie L. Himes and Arthur M. Krieg -- Prospects for TLR9- based immunotherapy for asthma and allergy / by David Broide -- Toll-like receptors in the development of systemic autoimmune disease : in vitro artifact or in vivo paradigm? / by Ann Rothstein -- Impacts of nucleoside modification on RNA-mediated activation of toll-like receptors / by Katalin Kariko and Drew Weissman -- Activation of innate pattern recognition pathways by single-stranded ribonucleic acids / by Sandra Diebold -- RNA interference in scope of immune system / by Andrea Ablasser, Gunther Hartmann, and Veit Hornung -- Recognition of RNA and synthetic compounds by TLR7 and TLR8 / by Svetlana Hamm and Stefan Bauer -- Helicases at frontline of RNA virus recognition / by Leonid Gitlin and Marco Colonna.Structural analysis of toll-like receptors / by Jungwoo Choe and Ian A. Wilson -- Antiviral signaling through TLRs and RLHs / by Taro Kawai -- Recognition of virus invasion by toll-like receptors and RIG-I-like helicases / by Hiroki Kato and Osamu Takeuchi -- Characteristics of dendritic cell responses to nucleic acids / by Tsuneyasu Kaisho, Takahiro Sugiyama, and Katsuaki Hoshino -- Dendritic cells as sensors for foreign and self nucleic acids / by Anne Krug and Wolfgang Reindl -- Natural DNA recognition by toll-like receptor 9 does not reply upon CpG motifs: role of endosomal compartmentation / by Tobias Haas ... [et al.] -- Discrimination of self and non-self DNA / by Katryn J. Stacey ... [et al.] -- Therapeutic potential of immunosuppressive oligonucleotides expressing TTAGGG motifs / by Dennis M. Klinman ... [et al.] -- Structure/function of IFN?-inducing CpG ODN / by Daniela Verthelyi and Montserrat Puig --
  • The second volume on One Health explains in detail how to implement three key aspects of the One Health paradigm food safety and security, national plans for a holistic one health approach, and relevant new technologies and approaches. The fourteen chapters, each by an internationally recognized authority, are organized into three sections of four or five chapters each, that break new ground in clarifying precisely how One Health can become an operational reality in local, national and international public health initiatives. Section three begins with an international overview on food safety and security. The importance of a One Heath approach is then explained in relation to four specific problems?the growing prevalence of antibiotic resistance, bovine spongiform encephalopathy and pathogenic E.coli. Section four begins with the role of the Food and Agricultural Organization (FAO) in promoting One Health. The formulation and implementation of national plans for implementing the One Health paradigm are then set out for Africa, the Western Pacific, Southeast Asia and Mongolia. The final section of this two volume book is devoted to implementing new technologies and new approaches to One Health. A wide-ranging analysis considers the importance of climate change and a social-ecological systems approach, as well as how to operationalize One Health, how to move from emergency response to prevention at source, and how to implement an educational strategy that builds a foundation for One Health in emerging disease management. It is anticipated that this two volume book will become a benchmark for practitioners of One Health, empowering a balanced multidisciplinary approach to the complexities of the human-animal-environment interface.
  • One Health: its origins and future -- One Health and emerging infectious diseases: clinical perspectives -- The historical, present, and future role of veterinarians in One Health -- The importance of understanding the human-animal interface -- The human environment interface: applying ecosystem concepts to health -- Wildlife: the need to better understand the linkages -- The economic value of One Health in relation to the mitigation of zoonotic disease risks -- The application of One Health approaches to henipavirus research -- H5N1 highly pathogenic avian influenza in Indonesia: retrospective considerations -- Rabies in Asia: the classical zoonosis -- Japanese encephalitis: on the One Health agenda -- Cost estimate of bovine tuberculosis to Ethiopia -- The pandemic H1N1 influenza experience -- One Health: the Hong Kong experience with avian influenza -- Clostridium difficile infection in humans and piglets: a 'One Health' opportunity -- Men, primates, and germs: an ongoing affair -- Erratum to: Cost estimate of bovine tuberculosis to Ethopia -- Index.
  • Osteoimmunology 2010, Springer
    The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis / Edward M. Schwarz ... [et al.] -- Activation of [gamma][delta] T cells by bisphosphonates / Keith Thompson ... [et al.] -- Identification of cell cycle-arrested quiescent osteoclast precursors in vivo / Naoyuki Takahashi ... [et al.] -- Megakaryocyte-bone cell interactions / Melissa A. Kacena and Wendy A. Ciovacco -- Regulation of osteoblast differentiation by Runx2 / Toshihisa Komori -- Communication between ephrinB2 and ephB4 within the osteoblast lineage / T.J. Martin ... [et al.] -- The unexpected link between osteoclasts and the immune system / Hiroshi Takayanagi -- NFATc1 in inflammatory and musculoskeletal conditions / Antonios O. Aliprantis and Laurie H. Glimcher -- Novel functions of RANK(L) signaling in the immune system / Andreas Leibbrandt and Josef M. Penninger -- Eph and ephrin interactions in bone / Koichi Matsuo -- How do bone cells secret proteins? / Haibo Zhao ... [et al.] -- Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and caspase-3 / Sakae Tanaka ... [et al.] -- Regulation of bone formation and immune cell development by Schnurri proteins / Dallas C. Jones and Laurie H. Glimcher.
  • Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. It has become increasingly clear that critical interactions between these two organ systems frequently occur. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. However, because these two disciplines developed independently, investigators in each don't always fully appreciate the significance of the other. This book is meant to provide a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. Approximately half the book will focus on the role that osteoimmunology plays in the development of human diseases.
  • Introduction: Oxidation and inflammation, a molecular link between non-communicable diseases -- Oxidative stress and DNA damage in obesity-related tumorigenesis -- High density lipoproteins and ischemia reperfusion injury: the therapeutic potential of HDL to modulate cell survival pathways -- The DING family of phosphate binding proteins in inflammatory diseases -- Inflammation, infection, cancer and all that...the role of paraoxonases -- Autophagy is an inflammation-related defensive mechanism against disease -- Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease -- Systemic inflammation, intestine and paraoxonase-1 -- Serotonin modulation of macrophage polarization: inflammation and beyond -- Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer -- Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties -- Postprandial inflammation: targeting glucose and lipids -- Dynamic interplay between metabolic syndrome and immunity -- The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease -- The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration.
  • Parasites and allergy 2006, Karger
  • Patch testing tips 2014, Springer
    This book is a compendium of tips on many different aspects of patch testing based on the recommendations of the International Contact Dermatitis Research Group (ICDRG), which is the reference group for all dermato-allergologists. It is intended to complement the book Patch Testing and Prick Testing: A Practical Guide by J.-M. Lachapelle and H. Maibach, which is an official publication of the ICDRG now in its third edition. Among the wide variety of topics covered are pitfalls, legal aspects, patch testing with ultrasonic bath extracts, the role of patch testing in occupational contact dermatitis and atopic dermatitis, semi-open tests, the implications of a negative test, patch testing validity, selection of extra allergens and patch testing in the tropics. Many illustrations are included and all information is completely up-to-date. This book will be of value to all practicing dermatologists.
  • Bacterial toxins as immunomodulators / David S. Donaldson and Neil A. Williams -- Innate immune evasion by staphylococci / Karin Ellen Veldkamp and Jos A.G. van Strijp -- Bacterial complement escape / Ilse Jongerius, Sanjay Ram, and Suzan Rooijakkers -- Modulation of innate immune signalling pathways by viral proteins / Orla Mulhern, Barry Harrington, and Andrew G. Bowie -- Viral TNF inhibitors as potential therapeutics / Masmudur M. Rahman, Alexandra R. Lucas, and Grant McFadden -- Lipoxins as an immune-escape mechanism / Fabiana S. Machado and Julio Aliberti -- Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES62 / William Harnett and Margaret M. Harnett -- Helminth-derived immunomodulatory molecules / Poom Adisakwattana ... [et al.] -- Fungal-derived immune modulating molecules / Tania C. Sorrell and Sharon C.A. Chen -- The immunosuppresive tick salivary protein, Salp15 / Ignacio J. Juncadella and Juan Anguita -- The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics / Alexandra Lucas ... [et al.] -- Helminthic therapy : using worms to treat immune-mediated disease / David E. Elliott and Joel V. Weinstock -- Chemokine binding proteins encoded by pathogens / Antonio Alcami and Margarida Saraiva.
  • Pathogenic spirochetes 2012, Springer
    This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites.
  • Handling of the lymph node biopsy -- Immunohistology and other diagnostic techniques -- Anatomical and functional components -- Nodular lymphoid infiltrates -- Diffuse lymphoid infiltrations -- Defining microscopic features -- Nodal involvement by leukemias and extranodal lymphomas -- Needle core biopsies and aspirates.
  • Review of immunology -- Immunology of IgE-mediated and other hypersensitivity responses -- Biochemical mediators of allergic reactions -- Evaluation and management of immune deficiency in allergy practice -- Evaluation of eosinophilia -- Allergens and other factors important in atopic disease -- Airborne pollen prevalence in the United States -- Diagnosis of immediate hypersensitivity -- Physiologic and biologic evaluation of allergic lung diseases -- Radiologic evaluation of allergic and related diseases of the upper airway -- Radiologic evaluation of allergic and related diseases of the lower airway -- Chronic rhinosinusitis role of rhinoscopy and surgery -- Principles of immunologic management of allergic diseases due to extrinsic antigens -- Anaphylaxis -- Allergy to stinging insects -- Erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis -- Drug allergy -- Food allergies -- Asthma -- The infant and toddler with asthma -- Management of acute severe asthma -- Asthma clinical trials -- Hypersensitivity pneumonitis -- Allergic bronchopulmonary aspergillosis -- Occupational immunlogic lung disease -- Allergic rhinitis -- Nasal polyposis, sinusitis, and nonallergic rhinitis -- Allergic diseases of the eye and ear -- Atopic dermatitis -- Contact dermatitis -- Urticaria, angioedema, and hereditary angioedema -- Approach to the patient with pruritus -- Antihistamines -- β [beta] agonists -- Corticosteroids in treatment of allergic diseases -- Other antiallergic drugs: cromolyn, nedocromil, antileukotrienes, anticholinergics, and theophylline -- Delivery devices for inhaled medications -- Novel immunologic therapies -- Allergic disorders and pregnancy -- Eosinophilic esophagitis -- Chronic cough -- Sleep disorders in the allergic patient -- Management of the psychologically complicated patient -- Controversial and unproved methods in allergy diagnosis and treatment.
  • Phosphoinositides and disease 2012, SpringerLink
    Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
  • Introduction / Vikas R. Dharnidharka, Michael Green and Steven Webber -- Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD) / Douglas W. Hanto -- Epidemiology of PTLD / Vikas R. Dharnidharka -- The Biology of Epstein-Barr Virus and Posttransplant Lymphoproliferative Disease / Olivia M. Martinez -- Epstein-Barr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders / Jutta K. Preiksaitis -- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder / Upton D. Allen -- Pathology / Steven H. Swerdlow -- Prognostic Factors for PTLD / Tapan Maniar and Donald Tsai -- Treatment of PTLD / Steven A. Webber -- Prevention of Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation / Michael Green and Marian Michaels -- Organ Specific Issues of PTLD - Kidney / Sophie Caillard -- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients / Jaime Pineda and George V. Mazariegos -- Heart and Lung Transplantation / Silke Wiesmayr and Steven A. Webber -- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT) / Thomas G. Gross -- Research Priorities and Future Directions / Vikas R. Dharnidharka, Michael Green and Steven A. Webber.
  • The field of contact dermatitis is potentially frustrating given the complexity of the clinical decision-making process and the effect of false positives and negatives on patient expectations and management. Practical Patch Testing and Chemical Allergens in Contact Dermatitis outlines the most common allergens with practical tips for patch testing in a concise and algorithmic fashion. Children have different needs for patch testing and this handbook describes how to test them safely and manage their disease. Educating patients on how to avoid their irritants and allergens is also key to treatment in all types of contact dermatitis. The authors have incorporated concise reference material on where these chemicals are found and how patients can avoid them. Clinical pearls for patch testing of certain allergens are clearly outlined in this handbook to help providers avoid common pitfalls and reduce the risk of incorrect diagnoses. A frustrating clinical visit and a disappointed patient can potentially be avoided with the use of this book, and thus is is an essential reference for trainees in dermatology and all involved in the management of patients with dermatitis.
  • Immunology for the Non-immunologist --Neurology for the Non-neurologist --Neuroimmunology for the Non-neuroimmunologist --The Prototypic Neuroimmunological CNS Disease: Multiple Sclerosis, a Precis --Multiple Sclerosis: Diagnosis --Multiple Sclerosis Mimics --Multiple Sclerosis Therapy --Experimental Models of MS --Guillain-Barré Syndrome (GBS) and Other Immune-Mediated Neuropathies --Neuromuscular Neuroimmunological Diseases: Myasthenia Gravis --The Prototypic Neuroimmunological Muscle Disease: Dermatomyositis --A Introduction to Neurological Infections: Neuro-infectious Disease as Part of Neuroimmunology --Neurological Manifestations of Systemic Chronic Inflammatory Disease --The Neuroimmunology of Cancer: Paraneoplastic Syndromes and Primary CNS Lymphoma --Neuroimmunology of Degenerative Diseases and Stroke --Important Rare Neuroimmunological Diseases --Neuroimmunological Molecules and Translational Medicine --Neuroimmunological Diagnostic Tests --Therapy in Neuroimmunological Disease.
  • Probiotics 2014, CRCnetBASE
    "Written by international experts, this book reviews recent, cutting-edge research on the use of immunoregulatory probiotics (immunobiotics) and their bioactive compounds (immunogenics) to prevent and improve health. Each chapter provides critical insight, reviews current research, discusses future perspective, and stimulates discussion. The book also dicsusses novel applications of immunobiotics such as their use in respiratory infections, regulation of the interaction between inflammation and coagulation as well as their effect on hematopoiesis"--Provided by publisher.
  • Procedia in vaccinology v. 1-, 2009-, ScienceDirect
  • Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.
  • Review of medical microbiology and immunology 2012 (12th ed.), AccessMedicine
  • Ricin and shiga toxins 2012, Springer
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • RNA interference 2008, Springer
    RNA interference in mammalian cell systems / Patrick J. Paddison -- RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard -- Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi ... [et al.] -- Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz -- The mechanism of RNase III action: how dicer dices / Xinhua Ji -- MicroRNA metabolism in plants / Xuemei Chen -- Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron -- RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire -- A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin -- RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris -- RNA silencing in mammalian oocytes and early embryos / Petr Svoboda -- Identifying human microRNAs / Isaac Bentwich.
  • Mechanisms of apoptosis during reovirus infection /P. Clarke ... [et al.] --Poliovirus, pathogenesis of poliomyelitis, and apoptosis /B. Blondel ... [et al.] --Neuronal cell death in alphavirus encephalomyelitis /D. E. Griffin --HSV-induced apoptosis in herpes encephalitis /L. Aurelian --Therole of apoptosis in defense against baculovirus infection in insects /R. J. Clem --Therole of host cell death in Salmonella infections /D. G. Guiney --Role of macrophage apoptosis in the pathogenesis of Yersinia /Y. Zhang, J. B. Bliska --Entamoeba histolytica activates host cell caspases during contact-dependent cell killing /D. R. Boettner, W. A. Petri --Interactions between malaria and mosquitoes : the role of apoptosis in parasite establishment and vector response to infection /H. Hurd, V. Carter, A. Nacer --Apoptosis and its modulation during infection with Toxoplasma gondii : molecular mechanisms and role in pathogenesis /C. G. K. Luder, U. Gross --Modulation of the immune response in the nervous system by rabies virus /M. Lafon --Apoptotic cells at the crossroads of tolerance and immunity /M. Skoberne ... [et al.].
  • v. 1. Recognition : innate and adaptive immunity -- Effector mechanisms : innate and adaptive -- Primary immunodeficiencies -- Proliferation disorders of immunologic cells -- v. 2. Systemic diseases -- Organ-specific diseases -- Allergic diseases -- Evasion, activation and ineffective immunity -- Transplantation -- Therapeutic immunology.
  • Sex differences in susceptibility to infection : an evolutionary perspective / Marlene Zuk and Andrew M. Stoehr -- Effects of sex steroids on innate and adaptive immunity / S. Ansar Ahmed, Ebru Karpuzoglu, and Deena Khan -- Sex steroid receptors in immune cells / Susan Kovats, Esther Carreras, and Hemant Agrawal -- Sex differences in susceptibility to viral infection / Sabra L. Klein and Sally Huber -- Sex differences in innate immune responses to bacterial pathogens / Jennifer A. Rettew, Ian Marriott, and Yvette M. Huet -- Sex hormones and regulation of host responses against parasites / James Alexander ... [et al.] -- Sex differences in parasitic infections : beyond the dogma of female-biased resistance / Galileo Escobedo, Marco A. De León, and Jorge Morale-Montor -- Progesterone, pregnancy, and innate immunity / Julia Szekeres-Bartho and Beata Polgar -- Pregnancy and susceptibility to parasites / Fiona L. Henriquez, Fiona M. Menzies, and Craig W. Roberts -- Sex steroids and risk of female genital tract infection / Patti Gravitt and Khalil Ghanem -- Sex, pregnancy, and measles / Allison C. Brown and William J. Moss -- Epilogue : challenges for the future / Craig W. Roberts and Sabra L. Klein.
  • Machine generated contents note: 1 Regulation of SignalTransduction by the Fcy Receptor Family -- Members and Their Involvement in Autoimmunity -- Coggeshall, K.M. (Oklahoma City, Okla.) -- 30 The Role ofTNF/TNFR in Organ-Specific and Systemic -- Autoimmunity: Implications for the Design of Optimized 'Anti-TNF' -- Therapies -- Kollias, G.; Kontoyiannis, D.; Douni, E.; Kassiotis, G. (Vari) -- 51 CD40 Signaling and Autoimmunity -- Cheng, G. (Los Angeles, Calif.); Schoenberger, S.P. (San Diego, Calif.) -- 62 TGF-j: Receptors, Signaling Pathways and Autoimmunity -- Chen, W; Wahl, S.M. (Bethesda, Md.) -- 92 lnterleukin-2 Signaling and the Maintenance of Self-Tolerance -- Nelson, B.H. (Seattle, Wash.) -- 113 Role of the B7-CD28/CTLA-4 Pathway in Autoimmune Disease -- Chang, T.T.; Kuchroo, VK.; Sharpe, A.H. (Boston, Mass.) -- 131 AbnormalT Lymphocyte Signal Transduction in Systemic Lupus -- Erythematosus -- Kammer, G.M. (Winston-Salem, N.C.); Tsokos, G.C. -- (Bethesda, Md./Silver Spring, Md.) -- 151 Lyn/CD22/SHP-1 and Their Importance in Autoimmunity -- Blasioli, J.; Goodnow, C.C. (Canberra) -- 161 Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases -- Fang, N.; Fang, D.; Wang, H.-Y.; Altman, A.; Liu, Y.-C. (San Diego, Calif.) -- 176 Keeping theT-Cell Immune Response in Balance: Role of Protein -- Tyrosine Phosphatases in Autoimmunity -- Mustelin, T. (La Jolla, Calif.) -- 191 Author Index -- 192 Subject Index.
  • Sjögren's syndrome 2012, Springer
  • Sjögren's syndrome 2011, Springer
    Introduction -- A Note from Sweden: Recollection of Henrik Sjögren -- Myths, Pearls, and Tips Regarding Sjögren's Syndrome -- Providing Information to Referring Physicians and Patients -- Current Concepts on Classification Criteria and Disease Status Indexes in Sjögren's Syndrome -- Histopathology and Glandular Biopsies in Sjögren's Syndrome -- Imaging Technology in Sjögren's Syndrome: Non-invasive Evaluation of the Salivary Glands -- Genomics and Viruses in Sjögren's Syndrome -- Autoantibodies and Autoantigens in Sjögren's Syndrome -- B-cell Epitopes of Sjögren's Syndrome-Related Autoantigens Ro/SSA and La/SSB -- Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function -- Overview of Management of Dry Eye Associated with Sjögren's Syndrome -- Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjögren's Syndrome -- Oral and Dental Manifestations of Sjögren's Syndrome: Current Approaches to Diagnostics and Therapy -- Etiology and Pathogenesis of Sjögren's Syndrome with Special Emphasis on the Salivary Glands -- Otolaryngologic Manifestations of Sjögren's Syndrome -- Extraglandular Manifestations of Sjögren's Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations -- Therapy of Dermatologic, Renal, Cardiovascular, Pulmonary, Gynecologic, Gastro-enterologic, Urologic and Fibromyalgia Manifestations Including Special Considerations at the Time of Surgery -- Current Treatment of Extraglandular Manifestations with Disease-Modifying and Immunosuppressive Agents -- Lymphoproliferation and Lymphoma in Sjögren's Syndrome -- Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjögren's Syndrome -- The Neurological Manifestations of Sjögren's Syndrome: Diagnosis and Treatment -- New Approaches for the Management of Dry Mouth in Sjögren's Syndrome in Japan -- New Approaches for the Management of Dry Mouth and Dry Eye in Sjögren's Syndrome in Japan Dry Eye Part -- Sjögren's Syndrome in Australia: Clinical Practice and Research -- Primary Sjögren's Syndrome: Report from India -- Sjögren's Syndrome in China -- Sjögren's Syndrome in China -- Sjögren's Syndrome in Israel: A Scientific Point of View -- Looking into the Future-The EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjögren's Syndrome -- Looking into the Crystal Ball: Initiatives from the Sjögren's Syndrome Foundation That Will Impact Patient Care -- Biological Treatment for Sjögren's Syndrome -- Looking into the Future-Emerging Therapies Based on Pathogenesis -- Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy.
  • Smallpox, a history 2013, ebrary
    "Scientifically known as Variola major, the deadliest form of smallpox has plagued mankind since 'time immemorial.' This text chronicles the worldwide effects of the killer disease, with particular emphasis on the 19th and 20th centuries, including the devastations of the "speckled disease" during great armed conflicts"--Provided by publisher.
  • Sparking signals 2008, Springer
  • Pattern recognition by B cells: the role of antigen repetitiveness versus toll-like receptors -- The multifunctional role of antibodies in the protective resonse to bacterial T cell-independent antigens -- The important anddiverse roles of antibodies in the host response to Borrelia infections -- A distinct role for B1b lymphocytes in T cell-independent immunity -- Secretory immunity following mutans streptococcal infection or immunization.
  • This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system.
  • Natural and induced T CD4+CD25+FOXP3+ regulatory T cells / L. Chatenoud -- Polyclonal expansion of human CD4(+)CD25(+) regulatory T cells / P. Hoffmann, R. Eder and M. Edinger -- Methods for in vitro generation of human type 1 regulatory T cells / S. Gregori, M.G. Roncarolo and R. Bacchetta -- Ex vivo generation of regulatory T cells: Characterization and therapeutic evaluation in a model of chronic colitis / F. Karlsson ... [et al.] -- Phenotypic and functional characterization of CD8(+) T regulatory cells / S. Menoret ... [et al.] -- Regulatory CD4(-)CD8(-) double negative T cells / E.Y. Kim, S.C. Juvet and L. Zhang -- Identifying regulatory B cells (B10 cells) that produce IL-10 in mice / T. Matsushita and T.F. Tedder -- DCs in immune tolerance in steady-state conditions / T. Fukaya ... [et al.] -- Plasmacytoid dendritic cells in tolerance / E. Gehrie ... [et al.] -- In vitro-generated DC with tolerogenic functions: Perspectives for in vivo cellular therapy / C. van Kooten and K.A. Gelderman -- Preparation of mouse bone marrow-derived dendritic cells with immunoregulatory properties / M. Segovia, M.C. Cuturi and M. Hill -- Myeloid-derived suppressor cells: Characterization and expansion in models of endotoxemia and transplantation / N. Van Rompaey and A. Le Moine -- Human regulatory macrophages / J.A. Hutchinson ... [et al.] -- NKT and tolerance / J. Diana ... [et al.] -- Antiinflammatory and immunosuppressive functions of mast cells / J. Kalesnikoff and S.J. Galli -- A mesenchymal stem cell potency assay / J. Jiao ... [et al.] -- In vitro analyses of the immunosuppressive properties of neural stem/progenitor cells using anti-CD3/CD28-activated T cells / V. Bonnamain, I. Neveu and P. Naveilhan -- Immunoregulatory properties of heme oxygenase-1 / P. Blancou ... [et al.] -- Indoleamine 2,3-dioxygenase and regulatory function: Tryptophan starvation and beyond / C. Orabona and U. Grohmann -- Regulatory T cell enrichment by IFN-[gamma] conditioning / G. Feng, K.J. Wood and A. Bushell -- Transforming growth factor-beta: Recent advances on its role in immune tolerance / P.Y. Mantel and C.B. Schmidt-Weber -- Induction of tolerogenic dendritic cells by NF-[kappa]b blockade and fcgamma receptor modulation / L.J. Carreno, C.A. Riedel and A.M. Kalergis -- Fine-tuning antitumor responses through the control of galectin-glycan interactions: An overview / M. Salatino and G.A. Rabinovich -- Regulation of lymphocytes by nitric oxide / C. Bogdan -- Pregnancy: Tolerance and suppression of immune responses / A. Leber ... [et al.] -- Organ transplantation: Modulation of t-cell activation pathways initiated by cell surface receptors to suppress graft rejection / K. Weatherly and M.Y. Braun -- Immunosuppressive mechanisms during viral infectious diseases / G. Sarikonda and M.G. von Herrath -- Ocular immune privilege sites / S. Masli and J.L. Vega -- Immunoprivileged sites: The testis / M. Fijak, S. Bhushan and A. Meinhardt.
  • Swine influenza 2013, Springer
    Overview of Influenza Viruses /Stephan Pleschka --History of Swine Influenza /Stacey Schultz-Cherry, Christopher W. Olsen, Bernard C. Easterday --Genetics, Evolution, and the Zoonotic Capacity of European Swine Influenza Viruses /Roland Zell, Christoph Scholtissek, Stephan Ludwig --History of Swine Influenza Viruses in Asia /Huachen Zhu, Richard Webby, Tommy T. Y. Lam, David K. Smith --Clinicopathological Features of Swine Influenza /B. H. Janke --Diagnostics and Surveillance for Swine Influenza /Susan Detmer, Marie Gramer, Sagar Goyal, Montserrat Torremorell --Contemporary Epidemiology of North American Lineage Triple Reassortant Influenza A Viruses in Pigs /Alessio Lorusso, Amy L. Vincent, Marie R. Gramer, Kelly M. Lager --History and Epidemiology of Swine Influenza in Europe /Ian H. Brown --Swine Influenza Viruses: An Asian Perspective /Young-Ki Choi, Philippe Noriel Q. Pascua, Min-Suk Song --Swine Influenza Virus Vaccines: To Change or Not to Change--That's the Question /Kristien Van Reeth, Wenjun Ma --Swine Influenza Virus Infections in Man /Whitney S. Krueger, Gregory C. Gray --Interspecies Transmission of Influenza A Viruses Between Swine and Poultry /Hadi M. Yassine, Chang-Won Lee, Yehia M. Saif --The 2009 Pandemic Influenza Virus: Where Did It Come from, Where Is It Now, and Where Is It Going? /Ian York, Ruben O. Donis --Pandemic Influenza A H1N1 in Swine and Other Animals /Julia Keenliside --Therapeutics Against Influenza /Elena A. Govorkova, Jonathan A. McCullers.
  • 1. Autoimmunity and autoimmune diseases like systemic lupus erythematosus -- 2. Overview of cellular immune function in systemic lupus erythematosus -- 3. Etiopathogenesis of systemic lupus erythematosus: the itineraries of three troikas -- 4. MHC class II and non-MHC genes in the pathogenesis of systemic lupus erythematosus -- 5. Genetic susceptibility and class III complement genes -- 6. Complement deficiency and systemic lupus erythematosus -- 7. Gender and age in systemic lupus erythematosus -- 8. Genes and genetics of murine systemic lupus erythematosus -- 9. Systemic lupus erythematosus in domestic animals -- 10. Anti-DNA antibodies: structure, assembly and diversity -- 11. Anticytoplasmic antibodies in SLE: antibodies to cytoplasmic antigens -- 12. Antihistone antibodies -- 13. Antibodies to non-histone agents in systemic lupus erythematosus -- 14. Immune complexes -- 15. Origins of antinuclear antibodies -- 16. The clinical presentation of systemic lupus erythematosus in adults -- 17. Neonatal lupus syndromes -- 18. Systemic lupus erythematosus in childhood -- 19. Imaging of systemic lupus erythematosus: state of the art -- 20. Monitoring patients and systemic lupus erythematosus -- 21. Laboratory evaluation of patients with systemic lupus erythematosus -- 22. Systemic lupus erythematosus pregnancy -- 23. Epidemiology of systemic lupus erythematosus -- 24. Overlap syndromes: mixed connective tissue disease and26. Neuropsychiatric systemic lupus erythematosus -- 27. Psychiatric aspects of systemic lupus erythematosus -- 28. Cognitive dysfunction in systemic lupus erythematosus -- 29. Systemic lupus erythematosus and the skin -- 30. Systemic lupus erythematosus and the kidney -- 31. Cardiovascular systemic lupus erythematosus -- Systemic lupus erythematosus and the cardiovascular system: vasculitis -- 33. Systemic lupus erythematosus and the lung -- 34. Nonhepatic gastrointestinal manifestations of systemic lupus erythematosus -- 35. Hepatic disease and systemic lupus erythematosus: coincidence or converence -- 36. The cellular hematology of systemic lupus erythematosus -- 37. Articular manifestations of systemic lupus erythematosus -- 38. Osteoporosis and metabolic bone disease in systemic lupus erythematosus -- 39. Immunology of antiphospholipid antibodies and co-factors -- 40. The clinical aspects of the antiphospholipid syndrome -- 41. The catastrophic antiphospholipid syndrome -- 42. Hematology: coagulation problems -- 43. The antiphospholipid syndrome: pathogenesis and implications for systemic lupus erythematosus -- 44. Pathophysiology of drug-induced systemic lupus erythematosus -- 45. Drug and environmental systemic lupus erythematosus: clinical manifestations and differences -- 46. Corticosteroid use in systemic lupus erythematosus -- 47. Antimalarials and immunosuppresive therapies -- 48. Unproven and experimentalSjögren's syndrome -- 25. Systemic lupus erythematosus and fibromyalgia --
  • Systems biology 2013, Springer
    First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.
  • T cell protocols. 2nd ed. 2009, Springer Protocols
    Analysis of frequency and phenotype of antigen-specific T cells / Angus Stock and Vincenzo Cerundolo -- B cell helper assays / Sergio Abrignani, ... [et al.] -- Transkingdom RNA interference (tkRNAi) / Thu A. Nguyen and Johannes H. Fruehauf -- Flow cytometry and cell activation / Sonia Gavasso -- Investigating T cells by polychromatic flow cytometry / Enrico Lugli, Leonarda Troiano, and Andrea Cossarizza -- Generation of human T cell clones / Sabrina Mariotti and Roberto Nisini -- Limiting dilution analysis of antigen-specific T cells / Jorge Carneiro, Lurdes Duarte, and Elisabetta Padovan -- T cell epitope-mapping by cytokine gene expression assay / Maurizio Provengano and Giulio C. Spagnoli -- Cytokine multiplex immunoassay / Wilco de Jager, Berent Prakken, and Ger T. Rijkers -- Purification of the T cell antigen receptor and analysis by blue-native PAGE / Mahima Swamy and Wolfgang W.A. Schamel -- Non-replicating recombinant vaccinia virus expressing CD80 to enhance T-cell stimulation / Paul Zajac.
  • T-cell lymphomas 2013, Springer
    The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
  • Macrophage pattern recognition receptors in immunity, homeostasis, and self tolerance / Subhankar Mukhopadhyay, Annette Plüddemann, and Siamon Gordon -- Pattern recognition by toll-like receptors / Stefan Bauer, Thomas Müller, and Svetlana Hamm -- Nod-like receptors : pivotal guardians of the immunological integrity of barrier organs / Philip Rosenstiel and Stefan Schreiber -- Toll-like receptors and nod-like receptors : domain architecture and cellular signalling / Tanja Langefeld ... [et al.] -- Humoral pattern recognition molecules : mannan-binding lectin and ficolins / Steffen Thiel and Mihaela Gadjeva --Lung surfactant proteins A and D as pattern recognition proteins / Patrick Waters ... [et al.] -- Pattern recognition by pentraxins / Alok Agrawal ... [et al.] -- Target pattern recognition by complement proteins of the classical and alternative pathways / Yu-hoi Kang ... [et al.] -- Pattern recognition in phagocytic clearance of altered self / Yoshinobu Nakanishi, Peter M. Henson and Akiko Shiratsuchi -- Structural basis of pattern recognition by innate immune molecules / Eamon P. McGreal -- Lessons from the fly : pattern recognition in Drosophila melanogaster / Subhamoy Pal and Louisa P. Wu -- Immune recognition of plasmodium-infected erythrocytes / Damien V. Cordery and Britta C. Urban -- Innate immune recognition in tuberculosis infection / Anthony G. Tsolaki.
  • Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su Antigen) -- GW/P-Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (GW) is the Drosophila melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-Mediated Gene Silencing -- Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities -- Deadenylation and P-Bodies -- Relationship of GW/P-Bodies with Stress Granules -- Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies -- An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.
  • Th 17 cells 2009, Springer
  • Therapeutic antibodies 2008, Springer
  • Setting up a Kinase Discovery and Development Project /Gideon Bollag --Drug Efficacy Testing in Mice /William Y. Kim, Norman E. Sharpless --Gastrointestinal Stromal Tumors /Cristina Antonescu --EGFR Mutant Lung Cancer /Yixuan Gong, William Pao --Targeting Oncogenic BRAF in Human Cancer /Christine A. Pratilas, Feng Xing, David B. Solit --Beyond BRAF in Melanoma /Adil Daud, Boris C. Bastian --JAK-Mutant Myeloproliferative Neoplasms /Ross L. Levine --Will Kinase Inhibitors Make it as Glioblastoma Drugs? /Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel --Predictive Genomic Biomarkers /Rakesh Kumar, Rafael G. Amado --Epigenetic Biomarkers /Timothy A. Chan, Stephen B. Baylin --Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer /Robert L. Cohen.
  • Overview of TNF superfamily : a chest full of potential therapeutic targets / Iqbal S. Grewal -- Therapeutic interventions targeting CD40l (CD154) and CD40 : the opportunities and challenges / Che-Leung Law and Iqbal S. Grewal -- Targeting TNF for treatment of cancer and autoimmunity / Gautam Sethi ... [et al.] -- Targeting of BAFF and APRIL for autoimmunity and oncology / Maureen C. Ryan and Iqbal S. Grewal -- The role of FASL and FAS in health and disease / Martin Ehrenschwender and Harald Wajant -- OX40 (CD134) and OX401 / Michael J. Gough and Andrew D. Weinberg -- Targeting CD70 for human therapeutic use / Tamar Boursalian ... [et al.] -- 4-1BB as a therapeutic target for human disease / Seung-Woo Lee and Michael Croft -- Rank(l) as a key target for controlling bone loss / Andreas Leibbrandt and Josef M. Penninger -- Targeting the light-HVEM pathway / Carl F. Ware --GITR : a modulator of immune response and inflammation / Giuseppe Nocentini and Carlo Riccardi -- Targeting CD30/CD30l in oncology and autoimmune and inflammatory diseases / Ezogelin Oflazoglu, Iqbal S. Grewal, and Hans Peter Gerber -- Tumor necrosis factor receptor superfamily member 21 : TNFR-related death receptor-6, DR6 / Robert Benschop, Tao Wei, and Songqing Na -- TRAIL and other TRAIL receptor agonists as novel cancer therapeutics / Christina Falschlehner ... [et al.] -- Therapeutic potential of VEGI/TL1A -- In autoimmunity and cancer / Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal.
  • The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
  • TNF-alpha inhibitors 2006, Springer
  • Introduction: toll receptors and the renaissance of innate immunity / Elizabeth H. Bassett and Tina Rich -- The function of toll-like receptors / Zlatko Dembic -- Structures and motifs involved in toll signaling / Monique Gangloff, Phumzile L. Ludidi and Nicholas J. Gay -- "Supramolecular" activation clusters in innate immunity / Martha Triantafilou and Kathy Triantafilou -- Interleukin-I receptor/toll-like receptor signaling / Harald Wajant, Peter Scheurich and Frank Henkler -- Virus induced signaling to initiate the interferon mediated anti-viral host response / Claudia Wietek and Luke A.J. O'Neill --The induction of dendritic cell activation and maturation by toll-like receptor signaling / Tsuneyasu Kaisho and Shizuo Akira -- Pathogen avoidance using toll signaling in C. elegans / Nathalie Pujol and Jonathan J. Ewbank -- Forward genetic analysis of TLR pathways: a shared system for the detection of endotoxin and viral infection / Bruce Beutler ... [et al.] -- Agonists of toll-like receptor 9: modulation of host immune responses with synthetic oligodeoxynucleotides / Ekambar R. Kandimalla and Sudhir Agrawal.
  • Toll-like receptors 2009, Springer
    Overview of toll-like receptors in the CNS / Tammy Kielian -- Toll-like receptors in bacterial meningitis / Uwe Koedel -- Toll-like receptors in brain abscess / Nilufer Esen and Tammy Kielian -- Toll-like receptors in CNS viral infections / Hyeon-Sook Suh, Celia F. Brosnan and Sunhee C. Lee -- Toll-like receptors in CNS parasitic infections / Bibhuti B. Mishra, Uma Mahesh Gundra and Judy M. Teale -- Toll-like receptors in neurodegeneration / Trevor Owens -- Toll-like receptors in spinal cord injury / Kristina A. Kigerl and Phillip G. Popovich -- Toll-like receptors in Alzheimer's disease / Gary E. Landreth and Erin G. Reed-Geaghan -- Toll-like receptors in multiple sclerosis / Michael K. Racke and Phil D. Drew -- Toll-like receptors in peripheral nerve injury and neuropathic pain / Donghoon Kim, Soojin Lee and Sung Joong Lee.
  • Transplantation immunology 2006, Springer Protocols
    Current status of renal transplantation / Christopher J. Callaghan and J. Andrew Bradley -- Current status of liver transplantation / Peter J. Friend and Charles J. Imber -- Current status of islet transplantation / Jonathan R.T. Lakey, Mohammadreza Mirbolooki, and A.M. James Shapiro -- Current status of lung transplantation / Allan R. Glanville -- Chronic rejection in the heart / Philip Hornick and Marlene Rose -- Direct and indirect allorecognition / Philip Hornick -- HLA typing and its influence on organ transplantation / Stephen Sheldon and Kay Poulton -- Strategies for gene transfer to solid organs: viral vectors / Charlotte Lawson -- Nonviral vectors / Louise Collins -- Detection and clinical relevance of antibodies after transplantation / John D. Smith and Marlene Rose --Reprogramming the immune system using antibodies / Luis Graca and Hermann Waldmann -- In vitro assays for immune monitoring in transplantation / Maria P. Hernandez-Fuentes and Alan Salama -- Proteomics and laser microdissection / Emma McGregor and Ayesha DeSouza -- Real-time quantitative polymerase chain reaction in cardiac transplant research / Leanne E. Felkin, Anne B. Taegtmeyer, and Paul J.R. Barton -- Organ preservation / Mark Hicks ... [et al.] -- Pharmacological manipulation of the rejection response / Peter Mark Anthony Hopkins -- Experimental models of graft arteriosclerosis / Bezhad Soleimani and Victor C. Shi.
  • From Darwin and Metchnikoff to Burnet and beyond / Cooper, E.L. -- General introduction to innate immunity: Dr. Jekyl/Mr. Hyde quality of the innate immune system / Zonker, K.S. -- The innate immune system of mammals and insects / Müller, U. ... [et al.] -- Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands / Areschoug, T., Gordon, S. -- Antimicrobial peptides in innate immune responses / Sorensen, O.E., Borregaard, N., Cole, A.M. -- Complement: an efficient sword of innate immunity / Rambach, G., Würzner, R., Speth, C. -- Antibacterial chemokines: actors in both innate and adaptive immunity / Eliasson, M., Egesten, A. -- The role of neutrophils and monocytes in innate immunity / Kantari, C., Pederzoli-Ribeil, M., Witko-Sarsat, V. -- Innate immune functions of the airway epithelium / Bartlett, J.A., Fischer, A.J., McCray, Jr, P.B. -- Oxidative innate immune defenses by Nox/Duox family NADPH oxidases / Rada, B., Leto, T.L. -- Aging and impairment of innate immunity / Nomellini, V., Gomez, C.R., Kovacs, E.J.
  • Tumor immunoenvironment 2013, Springer
    Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
  • Urticaria and angioedema 2010, Springer
    History of Urticaria / M. Greaves -- Aetiopathogenesis of Urticaria / Clive E. H. Grattan -- Classification of Urticaria / Torsten Zuberbier -- Impact of Urticaria: QOL and Performance / Ilaria Baiardini, Fulvio Braido and Giorgio Walter Canonica -- Acute Urticaria / Torsten Zuberbier -- Chronic Urticaria / Marcus Maurer -- Dermographic and Delayed Pressure Urticaria / Frances Lawlor -- Heat and Cold Urticaria / Carsten Bindslev-Jensen -- Solar Urticaria / Tatsuya Horikawa, Atsushi Fukunaga and Chikako Nishigori -- Cholinergic Urticaria and Exercise-Induced Anaphylaxis / Ruth A. Sabroe -- Contact Urticaria / Jürgen Grabbe -- Urticarial Syndromes and Autoinflammation / Kanade Shinkai and Kieron S. Leslie -- Urticaria Vasculitis / Lluís Puig -- Angioedema / Elena Borzova and Clive E. H. Grattan -- Therapy of Urticaria / Bettina Wedi -- Standard Operating Procedures: A Practical Approach / M. Metz and M Magerl.
  • Vaccine adjuvants 2006, Springer
    Microbial pathogenesis and the discovery of toll-like receptor function / Bruce Beutler -- Dendritic cells: targets for immune modulation by microbes and immunologists / Bali Pulendran ... [et al.] -- Achieving transcriptional specificity in NF-[gamma]B-dependent inflammatory gene expression / Gioacchino Natoli -- Adjuvants and the initiation of t-cell responses / Matthew F. Mescher, Julie M. Curtsinger, and Marc Jenkins -- Mechanism for recognition of CpG DNA / Kiyoshi Takeda, Hiroaki Hemmi, and Shizuo Akira -- CpG ODN as a Th1 immune enhancer for prophylactic and therapeutic vaccines / Arthur M. Kried and Heather L. Davis -- Modified bacterial toxins / Ed C. Lavelle, Olive Leavy, and Kingston H.G. Mills -- Glycosylphosphatidylinositol anchors as natural immunological adjuvants derived from protozoan parasites / Ricardo T. Gazzinelli ... [et al.] -- The immunomodulatory glycan LNFPIII/Lewis X functions as a potent adjuvant for protein antigens / Mitsuhiro Okano ... [et al.] -- Immune and antiviral effects of the synthetic immunomodulator murabutide: molecular basis and clinical potential / George M. Bahr -- Effect of QS-21 on innate and adaptive immune responses / Charlotte Read Kensil ... [et al.] -- Monophosphoryl lipid A and synthetic lipid a mimetics as TLR4-based adjuvants and immunomodulators / Jory Baldridge ... [et al.] -- Microparticles and DNA vaccines / Kimberly Denis-Mize ... [et al.].
  • Immunological approaches for tolerance induction in allergy -- Clinical experience with recombinant molecules for allergy vaccination -- Allergen-specific immunotherapy with recombinant allergens -- Vaccine approaches for food allergy -- Intralymphatic immunotherapy: From the rationale to human applications -- Induction of allergen-specific tolerance via mucosal routes -- T cell epitope-based allergy vaccines -- Allergen-specific immunotherapy: Towards combination vaccines for allergic and infectious diseases -- Passive immunization with allergen-specific antibodies -- Cell-based therapy in allergy -- Current strategies for allergen-specific immunotherapy at its centenary.
  • Part I. Pandemic Influenza Overview -- Pandemic influenza as a current threat -- Antigenic cross-reactivity among H5N1 Viruses -- -- Part II. Current Approaches for Human and Avian Vaccine Production -- Seasonal influenza vaccines -- Generation and characterization of candidate vaccine viruses for pre-pandemic influenza vaccines -- Live attenuated vaccines for pandemic influenza -- Influenza vaccines for avian species -- Development and application of avian influenza vaccines in China -- -- Part III. Novel Vaccine Approaches -- Designing vaccines for pandemic influenza -- Attenuated influenza virus vaccines with modified NS1 proteins -- DNA Vaccines against Influenza viruses -- Recombinant proteins produced in insect cells -- Influenza neuraminidase as a vaccine antigen -- Recombinant vectors as influenza vaccines -- Influenza virus-like particles as pandemic vaccines -- Pandemic influenza vaccines -- Adjuvants for pandemic influenza vaccines -- -- Part IV. Novel Approaches of Vaccine Delivery -- Transcutaneous immunization with influenza vaccines -- Microneedle-based vaccines -- -- Part V. Vaccine Evaluation, Production and Distribution -- Animal models for evaluation of influenza vaccines -- Immunosenescence and influenza vaccine efficacy -- Vaccines for pandemic influenza: summary of recent clinical trials -- Considerations for licensure of influenza vaccines with pandemic and pre-pandemic indications -- Strategies for broad global access to pandemic influenza -- Prioritization of pandemic influenza vaccine: rationale and strategy for decision-making.
  • Vaccines. 6th ed. 2013, ClinicalKey
    A short history of vaccination -- Vaccine immunology -- The vaccine industry -- Vaccine manufacturing -- Evolution of adjuvants across the centuries -- Vaccine additives and manufacturing residuals in the United States: licensed vaccines -- Passive immunization -- General immunization practices -- Adenovirus vaccines -- Anthrax vaccines -- Cholera vaccines -- Diphtheria toxoid -- Haemophilus influenzae vaccines -- Hepatitis A vaccines -- Hepatitis B vaccines -- Human papillomavirus vaccines -- Inactivated influenza vaccines -- Influenza vaccine-live -- Japanese encephalitis vaccines -- Measles vaccine -- Meningococcal vaccines -- Mumps vaccine -- Pertussis vaccines -- Plague vaccines -- Pneumococcal conjugate vaccine and pneumococcal common protein vaccines -- Pneumococcal polysaccharide vaccines -- Poliovirus vaccine-inactivated -- Poliovirus vaccine-live -- Rabies vaccines -- Rotavirus vaccines -- Rubella vaccine -- Smallpox and vaccinia -- Tetanus toxoid -- Tick-borne encephalitis virus vaccines -- Tuberculosis vaccines -- Typhoid fever vaccines -- Varicella vaccine -- Yellow fever vaccine -- Zoster vaccine -- Combination vaccines -- Biodefense and special pathogen vaccines -- Therapeutic cancer vaccines -- Cytomegalovirus vaccines -- Dengue vaccines -- Diarrhea caused by bacteria -- Ebola vaccine -- Epstein-Barr virus vaccines -- Hepatitis C vaccines -- Hepatitis E vaccines -- Herpes simplex virus vaccines -- Human immunodeficiency virus vaccines -- Lyme disease vaccines -- Malaria vaccines -- Noninfectious disease vaccines -- Respiratory syncytial virus and parainfluenza virus vaccines -- Parasitic disease vaccines -- Staphylococcus aureus vaccines -- Streptococcus group A vaccines -- Technologies for making new vaccines -- Alternative vaccine delivery methods -- The development of gene-based vectors for immunization -- Vaccination of immunocompromised hosts -- Vaccination of human immunodeficiency virus-infected persons -- Vaccines for international travel -- Vaccines for health care personnel -- Immunization in the United States -- Immunization in Europe -- Immunization in the Asia-Pacific region -- Immunization in developing countries -- Community immunity -- Economic analyses of vaccine policies -- Regulation and testing of vaccines -- Regulation of vaccines in Europe -- Regulation of vaccines in developing countries -- Vaccine safety -- Legal issues -- Ethics.
  • The History of Vaccine Challenges: Conquering Diseases, Plagued by Controversy /Laura A. Jana --Vaccine Development and Safety /Avinash K. Shetty --Known Vaccine-Associated Adverse Events /B. A. Pahud --Communicating Vaccine Risks and Benefits /Clea Sarnquist --Vaccine Refusal: Perspectives from Pediatrics /Kody Moffatt, Clancy McNally --The Anti-vaccine Movement: A Pharmacist's View /Jeffery Goad --Antivaccinationism: Parental Viewpoint /Anna M. Johnson --The Vaccine Misinformation Landscape in Family Medicine /Donald B. Middleton --Vaccines: Boon or Bane--A Nurse's Outlook /Catherine O'Keefe --The Controversy That Will Not Go Away: Vaccines and Autism /Archana Chatterjee, --Thimerosal and Other Vaccine Additives /James H. Conway --Perceived Risks from Live Viral Vaccines /Alice Pong, Mark Sawyer --Can Vaccines Cause Cancer? /Ann-Christine Nyquist --Autoimmunity, Allergies, and Asthma: A Relationship to Vaccines? /Harold C. Delasalas --The Role of Public Health Ethics in Vaccine Decision Making: Insights from the Centers for Disease Control and Prevention /Leonard Ortmann --Alternative Schedules: Why Not? /Michael J. Smith --Influenza Vaccines and Guillain Barré Syndrome /Nandini Bakshi, James J. Sejvar --Can Vaccines Cause Chronic Diseases? /Ann-Christine Nyquist --Kawasaki Disease and Sudden Infant Death Syndrome: Any Connection to Vaccination? /Kari Neemann --Political and Legal Issues in Vaccination /Linda K. Ohri --The Media's Role in Vaccine Misinformation /Paola Dees --Vaccines and the Internet /David M. Berman --An International Perspective on Vaccine Safety /Rajib Dasgupta --An Infection Prevention Perspective on Immunizations /Sharon Plummer --Insights from Public Health: A Framework for Understanding and Fostering Vaccine Acceptance /Glen J. Nowak, Kate LaVail.
  • Visualizing immunity 2009, Springer
    Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses / Andrew Bullen, Rachel S. Friedman, and Matthew F. Krummel -- Visualizing intermolecular interactions in T cells / Nicholas R.J. Gascoigne ... [et al.] -- Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse / Michael L. Dustin -- T cell migration dynamics within lymph nodes during steady state: an overview of extracellular and intracellular factors influencing the basal intranodal T cell motility / Tim Worbs and Reinhold Forster -- Chemoattractant receptor signaling and its role in lymphocyte motility and trafficking / John H. Kehrl, Il-Young Hwang, and Chung Park -- New insights into leukocyte recruitment by intravital microscopy / Alexander Zarbock and Klaus Ley -- Visualizing the molecular and cellular events underlying the initiation of B-cell activation / Naomi E. Harwood and Facundo D. Batista -- Tracking the dynamics of Salmonella specific T cell responses / James J. Moon and Stephen J. McSorley -- Imaging Listeria monocytogenes infection in vivo / Vjollca Konjufca and Mark J. Miller -- Inflammation on the mind: visualizing immunity in the central nervous system / Silvia S. Kang and Dorian B. McGavern -- Multiphoton imaging of cytotoxic T lymphocyte-mediated antitumor immune responses / Alexandre Boissonnas ... [et al.].
  • War in the body 2013, Springer
    In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.
  • The term psychoneuroimmunology was originally coined to acknowledge the existence of functional interactions between the brain, the immune system and the endocrine system. As our understanding deepens regarding the interplay between the brain and the way bodies function, the field continues to grow in importance.
all 402 titles

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