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all 587 titles

Allergy and Immunology

  • 2007 CRCnetBASE
    Cronstein, Bruce N.; Haskó, György; Szabó, Csaba.
  • 2007 Springer
    Fantuzzi, Giamila; Mazzone, Theodore.
    The adipose organ / Saverio Cinti -- Metabolism of white adipose tissue / Michel Beylot -- Leptin / Malaka B. Jackson and Rexford S. Ahima -- Adiponectin / Aimin Xu, Yu Wang, and Karen S.L. Lam -- Vasoactive factors and inflammatory mediators produced in adipose tissue / Gema Frohbeck -- Regulation of the immune response by leptin / Victor Sanchez-Margalet ... [et al.] -- Leptin in autoimmune disease / Giuseppe Matarese -- Leptin and gastrointestinal inflammation / Arvind Batra and Britta Siegmund -- Adiponectin and inflammation / Yuji Matsuzawa -- Macrophages, adipocytes, and obesity / Anthony W. Ferrante, Jr. -- Interactions of adipose and lymphoid tissues / Caroline M. Pond -- Adipose tissue and mast cells: adipokines as Yin-Yang modulators of inflammation / George N. Chaldakov ... [et al.] -- Bone marrow adipose tissue / Patrick Laharrague and Louis Castella -- Environmental aspects of obesity / Lisa Diewald, Myles S. Faith, and Meredith S. Dolan -- The genetics of obesity: five fundamental problems with the famine hypothesis / John R. Speakman -- Developmental perspectives on the origins of obesity / Cristopher W. Kuzawa, Peter D. Gluckman, and Mark A. Hanson -- The epidemiology of obesity / Carol A. Braunschweig -- Inherited and acquired lipodystrophies: disorders of adipose tissue, development, differentiation, and death / Vinaja Simha and Anil Agarwal -- Mechanisms of cachexia / Robert H. Mak and Wai W. Cheung -- Adipose tissue and insulin resistance / Stephen E. Borst -- Adipokines in non-alcoholic fatty liver disease / Ancha Baranova and Zobair M. Younossi -- Adiposity and cancer / Eugenia E. Calle -- Obesity and cardiovascular disease / Alison M. Morris, Paul Poirier, and Robert H. Eckel -- Obesity and asthma / Elisabeth Luder -- Adiposity and kidney disease / Srinivasan Beddhu and Bonnie Ching-Ha Kwan -- Obesity and joint disease / Andrew J. Teichtahl, Anita E. Wluka, and Flavia M. Cicuttini -- Effect of weight loss on disease / Sergio Jose Bardaro, Dennis Hong, and Lee Swanstrom.
  • 2014 Future Med
    Moneret-Vautrin, Denise Anne.
    Advances in anaphylaxis management / Denise Anne Moneret-Vautrin -- Anaphylaxis : classification and clinical symptoms / Johannes Ring, Jarmila Liptak & Knut Brockow -- Pathophysiology : IgE-mediated and non-IgE-mediated anaphylaxis / Denise Anne Moneret-Vautrin -- Risk factors for fatal anaphylaxis / Richard Pumphrey & Gunter Sturm -- Etiologies of anaphylaxis / Margitta Worm -- Biomarkers for the evaluation of severity of anaphylaxis / Julia Upton & Peter Vadas -- Role of specific IgE testing in allergy diagnosis / Sandrine Jacquenet, Denise-Anne Moneret-Vautrin & Bernard E. Bihain -- Treatment algorithm for anaphylaxis and prognosis / Ben Gibbison & Jasmeet Soar -- Food anaphylaxis prevention / Martine Morisset -- Hymenoptera anaphylaxis : indications and results of immunotherapy / Ulrich R. Müller & Arthur Helbling -- Index.
  • 2013 Springer
    Freed, Eric O.
    Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.
  • 2014 Springer
    Rosenblatt, Joseph D.
    Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
  • 2012 Karger
    French, Lars E.
    "The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1 to 5 percent for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists." -- publisher's site.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    Respiratory allergy is constantly encountered and is sharply on the rise, particularly in the two most vulnerable age-groups: young children and seniors. Allergy results in airway hyperactivity and increased airway resistance, with all inflammatory sequelae being ensued. The chapters show how respiratory allergy research is interconnected with other disciplines by discussing neurotransmitter, membrane receptor, and ionic channel mechanisms of allergy and by giving diagnostic and pharmacological cues on desensitization and therapy.
    Also available: Print – 2015
  • 2007 Springer
    Anderson, John A.; Lieberman, Phil L.
    Allergic disease: pathophysiology and immunopathology -- Approach to the allergic patient -- Diagnostic tests in allergy -- Environmental allergens -- Anaphylaxis -- Insect sting allergy -- The child with asthma -- Asthma in adults: diagnosis and management -- Allergic rhinitis: diagnosis and treatment -- Sinusitis and otitis media -- Diagnosis and treatment of ocular allergy -- Urticaria and angioedema -- Atopic dermatitis -- Contact dermatitis and other contact reactions -- Food allergy and intolerance -- Allergic and allergic-like reactions to drugs and other therapeutic agents -- Antihistamines -- β-adrenergic agonists -- Theophylline -- Antileukotriene agents in the management of asthma -- Cromolyn and nedocromil: nonsteroidal anti-inflammatory therapy for asthma and other allergic diseases -- Anticholinergic agents in respiratory diseases -- Glucocorticoid therapy in asthma -- Anti-IgE therapy -- Environmental control of respiratory indoor allergens -- Allergen immunotherapy -- Controversies in allergy and allergy-like diseases -- The patient with 'too many infections'.
  • 2006 Karger
    Crameri, Reto.
    Also available: Print – 2006
  • 2012 Karger
    Bienenstock, John.
    Relations between asthma and psychological distress: an old idea revisited -- Brain and asthma: what are the linkages? -- Stress-related programming of autonomic imbalance: role in allergy and asthma -- Role of parasympathetic nerves and muscarinic receptors in allergy and asthma -- Developmental programming of allergic diseases -- Mind-body interrelationship in DNA methylation -- Neurotrophins in chronic allergic airway inflammation and remodeling -- Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system -- Allergen-induced neuromodulation in the respiratory tract -- Role of microbiome in regulating the HPA axisd and its relevance to allergy -- Autonomic regulation of anti-inflammatory activities from salivary glands -- Mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses -- Neural and behavioral correlates of food allergy -- Neuroendocrine-immune connection regulates chronic inflammatory disease in allergy -- Itch and the brain.
  • 2015 Springer
    Raz, E.; Tao, Ailin.
    Allergic Disease Epidemiology -- The Pathogenesis of Allergy: A Brief Introduction -- Genetics and Epigenetic Regulation in Allergic Diseases -- Cross-Reactivity -- From Allergen Extracts to Allergen Genes and Allergen Molecules -- Allergen Gene Cloning -- High Throughput Screening of Allergy -- Surrogate Markers for Allergen-Specific Immunotherapy -- Immune Responses to Allergens in Atopic Disease: Considerations for Bioinformatics -- Antigenicity, Immunogenicity and Allergenicity -- Bioinformatic Classifiers for Allergen Sequence Discrimination -- Strategies for the Modification and Evaluation of Allergenicity -- Bioinformatics Methods to Predict Allergen Epitopes -- Allergen Database.
  • v. 1-6, 2009-2010. Springer
    v. 2, 2009 Springer
    v. 3, 2009 Springer
    v. 4, 2009 Springer
    v. 5, 2010 Springer
    v. 6, 2010 Springer
    Holgate, S. T.; Pawankar, Ruby; Rosenwasser, Lanny J.
    v. 1. Epigenetics, allergens and risk factors -- v. 2. Classification and pathomechanisms -- v. 3. Clinical manifestations -- v. 4. Diagnosis and health economics -- v. 5. Therapy and prevention -- v. 6. Future perspectives.
  • 2008 Springer Protocols
    Jones, Meinir G.; Lympany, Penny.
    Understanding of the molecular mechanisms of allergy / Meinir Jones -- T cell : primary culture from peripheral blood / Monika Raulf-Heimsoth -- Production of T-cell lines / Helga Kahlert -- Production of human T-cell clones / Adrienne Verhoef -- Mapping of human T-cell epitopes of allergens / Thomas Zeiler and Tuomas Virtanen -- Determining MHC restriction of T-cell responses / Mark Larché -- Short-term culture of CD8 cells and intracellular cytokine staining / Beejal Vyas and Alistair Noble -- Isolation, flow cytometric analysis, and suppression assay of CD4+ CD25+ T-regulatory cells / Hayley Jeal -- Monocyte-derived dendritic cells as antigen-presenting cells in T-cell proliferation and cytokine production / Sun-sang J. Sung -- Ultrasensitive ELISA for measurement of human cytokine responses in primary culture / William P. Stefura ... [et al.] -- Quantification of human chemokine production in TLR-stimulated and antigen-specific recall responses / Monique Stinson ... [et al.] -- Standardization of allergen extracts / Jørgen Nedergaard Larsen and Sten Dreborg -- Immunoelectrophoresis for the characterization of allergen extracts / Gitte Nordskov Hansen and Jørgen Nedergaard Larsen -- Conjugation of haptens / Ranulfo Lemus and Meryl H. Karol -- Monoclonal antibodies / Helga Kahlert and Oliver Cromwell -- Purification of antibodies / Per H. Larsson -- Collection of air samples to quantify exposure to airborne allergens / Susan Gordon -- Assay of air sample eluates / Anne Renström and Susan Gordon -- The halogen assay : a new technique for measuring airborne allergen / Euan Tovey ... [et al.] -- Measurement of specific IgG anti-Fel d 1 antibodies / Meinir G. Jones -- The facilitated antigen binding (FAB) assay : a protocol to measure allergen-specific inhibitory antibody activity / James N. Francis -- Microscopic identification and purity determination of pollen grains / Magdalena Rahl -- Biopanning for the characterization of allergen mimotopes / Isabella Pali-Schöll and Erika Jensen-Jarolim -- Identification of mast cells and mast cell subpopulations / Mark Buckley and Andrew F. Walls -- Purification and characterization of mast cell tryptase and chymase from human tissues / Alan R. McEuen and Andrew F. Walls -- Experimental activation of mast cells and their pharmacological modulation / Shaoheng He and Andrew F. Walls -- In situ hybridization / Kayhan T. Nouri-Aria.
  • 2012 ScienceDirect
    2011 ClinicalKey
    Broide, David H.; Church, Martin; Holgate, S. T.; Martinez, Fernando D.
    The new edition of Allergy, by Drs. Stephen Holgate, Martin Church, David Broide, and Fernando Martinez, uses an enhanced clinical focus to provide the clear, accessible guidance you need to treat allergy patients. A more consistent format throughout features new differential diagnosis and treatment algorithms, updated therapeutic drug information in each chapter, and additional coverage of pediatric allergies. With current discussions of asthma, allergens, pollutants, drug treatment, and more, as well as access to the full text and illustrations online at www.expertconsult.com, this comprehensive resource is ideal for any non-specialist who treats patients with allergies. Prescribe appropriate therapies and effectively manage patients' allergies using detailed treatment protocols. Identify allergic conditions quickly and easily with algorithms that provide at-a-glance assistance. Explore topics in greater detail using extensive references to key literature.
  • 2010 Karger
    Ring, Johannes.
    History and epidemiology -- History and classification of anaphylaxis -- Epidemiology of anaphylaxis -- Mechanisms -- T-cell response to allergens -- Anaphylaxis: mechanisms of mast cell activation -- Kinins, airway obstruction, and anaphylaxis -- Role for basophils in systemic anaphylaxis -- Human cardiac mast cells in anaphylaxis -- Diagnosis and clinical symptomatology -- Mastocytosis -- In vitro diagnosis of anaphylaxis -- Allergens and elicitors -- Insect venoms -- Classification and pathophysiology of radiocontrast media hypersensitivity -- Analgesics -- Anaphylaxis to general anesthetics -- Anaphylactic reactions to local anesthetics -- Treatment and prevention -- Anaphylaxis: acute treatment and management -- Epinephrine (adrenaline) in anaphylaxis.
  • 2011 Springer
    Castells, Mariana C.
    Definition and criteria for the diagnoses of anaphylaxis -- An epidemiological approach to reducing the risk of fatal anaphylaxis -- Pathophysiology and organ damage in anaphylaxis -- Mast cells: effector cells of anaphylaxis -- Basophils in anaphylaxis -- Protease mediators of anaphylaxis -- Aspirin and NSAID reactions: diagnosis, pathophysiology, and management -- IgE-dependent and independent effector mechanisms in human and murine anaphylaxis -- Food-induced anaphylaxis -- Antibiotic-induced anaphylaxis -- Anaphylaxis during radiological procedures and in the peri-operative setting -- Hymenoptera-induced hypersensitivity reactions and anaphylaxis -- Idiopathic anaphylaxis -- Exercise-induced anaphylaxis and food-dependent exercise-induced anaphylaxis -- Mastocytosis and mast cell activation syndromes presenting as anaphylaxis -- Anaphylaxis in mastocytosis -- Flushing and urticarial syndromes presenting as anaphylaxis -- Pharmacologic management of acute anaphylaxis -- Drug desensitizations in the management of allergy and anaphylaxis to chemotherapeutic agents and monoclonal antibodies -- Rapid desensitizations for antibiotic-induced hypersensitivity reactions and anaphylaxis -- Induction of tolerance for food-induced anaphylaxis -- Management of anaphylaxis: relevance of causes and future trends in treatment.
  • 2014 Karger
    Granata, Francescopaolo; Marone, G.
    History of research on angiogenesis -- Immune cells as a source and target of angiogenic and lymphangiogenic factors -- Neuropilins: role in signalling, angiogenesis and disease -- Class 3 semaphorin in angiogenesis and lymphangiogenesis -- Angiogenic and antiangiogenic chemokines -- Role of uPA/uPAR in the modulation of angiogenesis -- Neutrophil-derived cytokines involved in physiological and pathological angiogenesis -- Roles of eosinophils in the modulation of angiogenesis -- Regulatory T cells, leptin and angiogenesis -- Angiogenesis as a therapeutic target for obesity and metabolic diseases -- Angiogenesis in multiple myeloma -- Angiogenesis inhibitors in the treatment of prostate cancer -- Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease.
  • 2012 Springer Protocols
    Chames, Patrick.
    1. Use of IMGT® databases and tools for antibody engineering and humanization / Marie-Paule Lefranc, Franc̦ois Ehrenmann, Chantal Ginestoux, Véronique Giudicelli, and Patrice Duroux -- 2. Computer-assisted modeling of antibody variable domains / Oscar H.P. Ramos -- 3. Cloning single-chain antibody fragments (scFv) from hyrbidoma cells / Lars Toleikis and André Frenzel -- 4. Human in-cell scFv library from infiltrating B cell / Sylvie Peraldi-Roux -- 5. Construction of human naive antibody gene libraries / Michael Hust, Andreí Frenzel, Torsten Meyer, Thomas Schirrmann, and Stefan Dübel -- 6. Synthetic customized scFv libraries / Gautier Robin and Pierre Martineau -- 7. Selection of stable scFv antibodies by phage display / Eeva-Christine Brockmann -- 8. Generation of single domain antibody fragments derived from camelids and generation of manifold constructs / Cécile Vincke, Carlos Gutiérrez, Ulrich Wernery, Nick Devoogdt, Gholamreza Hassanzadeh-Ghassabeh, and Serge Muyldermans -- 9. Generation and isolation of target-specific single-domain antibodies from shark immune repertoires / Mischa Roland Müller, Ronan O'Dwyer, Marina Kovaleva, Fiona Rudkin, Helen Dooley, and Caroline Jane Barelle -- 10. Generation of human single domain antibody repertoires by Kunkel mutagenesis / Romain Rouet, Kip Dudgeon, and Daniel Christ -- 11. Phage display and selections on purified antigens / Julie Matz and Patrick Chames -- 12. Phage display and selections on cells / Klervi Even-Desrumeaux and Patrick Chames -- 13. Humanization by CDR grafting and specificity-determining residue grafting / Jin Hong Kim and Hyo Jeong Hong -- 14. Humanization by guided selections / Sang Jick Kim and Hyo Jeong Hong -- 15. Selection of antibody fragments by yeast display / Nathalie Scholler -- 16. Evolution of antibodies in vitro by ribosome display / Bryan M. Edwards and Mingyue He -- 17. Mammalian cell surface display of full length IgG / Chen Zhou and Wenyan David Shen -- 18. Production of antibody fragments in Escherichia coli / Tomohisa Katsuda, Hiroyuki Sonoda, Yoichi Kumada -- 19. Production of antibody derivatives in the methylotrophic yeast Pichia pastoris / Steve Schoonooghe, Jannick Leoen, and Jurgen Haustraete -- 20. Monoclonal antibody expression in mammalian cells / Richard Yi Zhang and Wenyan David Shen -- 21. Production of recombinant antibodies in Drosophila melanogaster S2 cells / Daniel X. Johansson, Thomas Krey, and Oskar Andersson -- 22. Production of antibody fragments using the baculovirus-insect cell system / Takanori Furuta, Takafumi Ogawa, and Hideki Yamaji -- 23. Transient and stable expression of antibodies in Nicotiana species / Freydoun Garabagi, Michael D. McLean, and J. Christopher Hall -- 24. Measuring antibody-antigen binding kinetics using surface plasmon resonance / Stephen Hearty, Paul Leonard, and Richard O'Kennedy -- 25. Affinity determination of biotinylated antibodies by flow cytometry / Klervi Even-Desrumeaux and Patrick Chames -- 26. Affinity maturation of antibodies : optimized methods to generate high-quality scFv libraries and isolate IgG candidates by high-throughput screening / Laurence Renaut, Céline Monnet, Olivier Dubreuil, Ouafa Zaki, Fabien Crozet, Khalil Bouayadi, Hakim Kharrat, and Philippe Mondon -- 27. Affinity maturation by semi-rational approaches / Rodrigo Barderas, Johan Desmet, Philippe Alard, and J. Ignacio Casal -- 28. Molecular scanning : combining random mutagenesis, ribosome display, and bioinformatic analysis for protein engineering / Alfredo Darmanin-Sheehan, William James Jonathan Finlay, Orla Cunningham, and Brian Joseph Fennell -- 29. Fucose-targeted glycoengineering of pharmaceutical cell lines / Christiane Ogorek, Ingo Jordan, Volker Sandig, and Hans Henning von Horsten -- 30. Fc engineering : design, expression, and functional characterization of antibody variants with improved effector function / Stefanie Derer, Christian Kellner, Sven Berger, Thomas Valerius, and Matthias Peipp -- 31. Fc engineering : serum half-life modulation through FcRn binding / Tove Olafsen -- 32. Monoclonal antibody lead characterization : in vitro and in vivo methods / Axel Hernandez, Julie Parmentier, Youzhen Wang, Jane Cheng, and Gadi Gazit Bornstein -- 33. Production, purification, and characterization of scFv TNF ligand fusion proteins / Andrea Fick, Agnes Wyzgol, and Harald Wajant --34. Antibody-IL2 fusion proteins for tumor targeting / Andreas A. Hombach and Hinrich Abken -- 35. Recombinant immunotoxins with low endotoxins for clinical and animal studies / Masanori Onda -- 36. Chimeric antigen receptors for T-cell based therapy / Eleanor J. Cheadle, Vicky Sheard, Andreas A. Hombach, Markus Chmielewski, Tobias Riet, Cor Berrevoets, Erik Schooten, Cor Lamers, Hinrich Abken, Reno Debets, and David E. Gilham -- 37. Selection and use of intracellular antibodies (intrabodies) / Sandrine Moutel, Clément Nizak, and Franck Perez -- 38. Radiolabeled antibodies for cancer imaging and therapy / Jacques Barbet, Manuel Bardiès, Mickael Bourgeois, Jean-Franc̦ois Chatal, Michel Chérel, Franc̦ois Davodeau, Alain Faivre-Chauvet, Jean-Franc̦ois Gestin, and Franc̦oise Kraeber-Bodéré -- 39. Design and production of multimeric antibody fragments, focused on diabodies with enhanced and clinical efficacy / Glenn A. Powers, Peter J. Hudson, and Michael P. Wheatcroft -- 40. Production of bispecific antibodies : diabodies and tandem scFv / Nora Hornig and Aline Färber-Schwarz.
  • v. 1-2, 2010. Springer
    v. 2, 2010 Springer
    Dübel, Stefan; Kontermann, Roland.
  • 2014 ScienceDirect
    Ackerman, Margaret E.; Nimmerjahn, Falk.
    Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.
  • 2012 Springer Protocols
    Ebersbach, Hilmar; Proetzel, Gabriele.
    Antigen presentation for the generation of binding molecules / Hilmar Ebersbach, Gabriele Proetzel, and Chonghui Zhang -- Recombinant antibodies and in vitro selection technologies / C. Ronald Geyer [and others] -- Phage display / Konstantin Petropoulos -- Generation of human fab libraries for phage display / Christoph Rader -- Selection of human fab libraries by phage display / Christoph Rader -- Ribosome Display / George Thom and Maria Groves -- Hybridoma technology for the generation of monoclonal antibodies / Chonghui Zhang -- Application of transgenic mice for therapeutic antibody discovery / E-Chiang Lee and Michael Owen -- Production of human or humanized antibodies in mice / Brice Laffleur [and others] -- Immortalization of human B cells : analysis of B cell repertoire and production of human monoclonal antibodies / Elisabetta Traggiai -- Kinetic screening in the antibody development process / Michael Schraml and Matthias Biehl -- Temperature-dependent antibody kinetics as a tool in antibody lead selection / Michael Schraml and Leopold von Proff -- Determination of antibody glycosylation by mass spectrometry / Christiane Jager [and others] -- Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format / Jiahui Yang and Christoph Rader -- PEGylation of antibody fragments for half-life extension / Simona Jevsevar, Mateja Kusterle, and Maja Kenig -- Bispecific antibody derivatives based on full-length IgG formats / Michael Grote [and others] -- Generation of fluorescent IgG fusion proteins in mammalian Cells / Alexander K. Haas, Klaus Mayer, and Ulrich Brinkmann -- Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function / Robert F. Kelley and Y. Gloria Meng -- Class-specific effector functions of therapeutic antibodies / Virginie Pascal, Brice Laffleur, and Michel Cogne.
  • 2012 Springer
    Kosma, Paul; Müller-Loennies, Sven.
    Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. ãaAnticarbohydrate Antibodies ãa from molecular basis to clinical applicationãa compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
  • 2013 Springer Protocols
    Endert, Peter van.
    Purification of large cytosolic proteases for in vitro assays: 20S and 26S proteasomes -- Analysis of proteasome generated antigenic peptides by mass spectrometry -- Using protease inhibitors in antigen presentation assays -- Kinetic studies of cytoplasmic antigen processing and production of MHC class I ligands -- Assaying peptide translocation by the peptide transporter TAP -- In vitro reconstitution of the MHC class I peptide-loading complex -- Studying mhc class i peptide loading and exchange in vitro -- Measuring synthesis and degradation of MHC class I molecules -- Studying ubiquitination of MHC class I molecules -- Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach -- Determining the activity of the transporter associated with antigen processing in the compartments of the secretory pathway -- Biochemical large-scale identification of MHC class I ligands -- Establishing MHC class I peptide motifs -- Quantitating MHC class I ligand production and presentation using TCR-like antibodies -- Biochemical analysis of naturally processed antigenic peptides presented by MHC class I molecules -- Identifying source proteins for MHC class I-presented peptides -- Purification, preparation, and use of chaperone-peptide complexes for tumor immunotherapy -- Recombinant poxviruses: Versatile tools for immunological assays -- Bioinformatics identification of antigenic peptide: Predicting the specificity of major MHC class I and II pathway players -- Evaluating CD8(+) T cell responses in vitro -- Cloning CD8(+) cytolytic T lymphocytes -- Production of CD4(+) and CD8 (+) T cell hybridomas -- Tracking antigen-specific CD8(+) T cells using MHC class I multimers -- The purification of large numbers of antigen presenting dendritic cells from mouse spleen -- Preparation of dendritic cells by in vitro cultures -- Monitoring dendritic cell activation and maturation -- Monitoring the intracellular routing of internalized antigens by immunofluorescence microscopy -- Isolation of a specialized, antigen-loaded early endosomal subpopulation by flow cytometry -- Preparing antigens suitable for cross-presentation assays in vitro and in vivo -- Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors -- Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading -- Assembly of matched [alpha/beta] subunits to HLA class II peptide receptors -- Studying MHC class II peptide loading and editing in vitro -- Study of the allogeneic response induced by endothelial cells expressing hla class ii after lentiviral transduction -- Antigen processing for mhc presentation via macroautophagy -- Studying MHC class II transport in dendritic cells -- In vitro digestion with proteases producing MHC class II ligands -- MHC-II ubiquitination -- Studying MHC class II presentation of immobilized antigen by B lymphocytes -- Production of primary human CD4(+) T cell lines and clones -- Analyzing antigen recognition by natural killer T cells -- Chromatofocusing purification of CD1B-antigen complexes and their analysis by isoelectric focusing.
  • 2016 Springer
    Harder, Jürgen; Schröder, Jens-Michael.
    Antimicrobial peptides in cutaneous wound healing -- Antimicrobial peptides as endogenous antibacterials and antivirals at the ocular surface -- Function of antimicrobial peptides in lung innate immunity -- Role of antimicrobial peptides to prevent infections in the kidney and urinary tract -- Antimicrobial peptides in the gut -- Metal sequestration: An important contribution of antimicrobial peptides to nutritional immunity -- Regulation of antimicrobial peptide gene expression by vitamin D -- Dichotomous roles of cationic polypeptides targeting HIV -- Antimicrobial peptides in host-defense: functions beyond antimicrobial activity.
  • 2013 Springer
    Hiemstra, Pieter S.; Zaat, Sebastian A. J.
    Evolution of Antimicrobial Peptides: A View from the Cystine Chapel -- Innate Immunity in Plants: The Role of Antimicrobial Peptides -- Antimicrobial Peptides Produced by Microorganisms -- LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide -- Wound Repair and Antimicrobial Peptides -- WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2 -- Histatins: Multifunctional Salivary Antimicrobial Peptides -- Structure-Function Relationships of Antimicrobial Chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial Peptides and Inflammatory Bowel Disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial Peptides in Chronic Obstructive Pulmonary Disease -- Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo -- Helping the Host: Induction of Antimicrobial Peptides as a Novel Therapeutic Strategy Against Infections.
    Also available: Print – 2013
  • 2015 Springer
    Meroni, Pier-Luigi.
    This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss or complications are explained. The main clinical manifestations and classification criteria are described and diagnostic tools, identified. Close attention is paid to the nature of the involvement of other organs or organ systems in APS, including the nervous, endocrine, hematologic, cardiovascular, and gastrointestinal systems, the kidney, the skin, and the eye. Specific chapters describe the treatment of the different symptoms, the preventive therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome
  • 2012 Springer
    Erkan, Doruk; Pierangeli, Silvia S.
    Part 1. History of Antiphospholipid Syndrome -- 1. Overview of the Last 25 Years and 13 International Congresses on Antiphospholipid Antibodies / Eon Nigel Harris and Silvia S. Pierangeli -- Part II. Basic Science Aspects of Antiphospholipid Syndrome -- 2. What is the Oirgin of Antiphospholipid Antibodies? / Rohan Willis, Yehuda Shoenfeld, Silvia S. Pierangeli and Miri Blank -- 3. What is the Genetics of Antiphospholipid Antibodies/Syndrome? / Thomas L. Ortel, Pier Luigi Meroni, Marta E. Alarcón-Riquelme, Maria O. Borghi and Joan T. Merrill -- 4. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Thrombosis? / Rohan Willis, Ian P. Giles, Pojen P. Chen, Chary López-Pedrera and María José Cuadrado, and Silvia S. Pierangeli -- 5. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity? / Vikki M. Abrahams, Maria O. Borghi, Pier Luigi Meroni, Jacob H. Rand, Elena Raschi, Jane E. Salmon, Francesco Tedesco, and Angela Tincani -- 6. What are the Target Cells and Receptors that are Recognized by Antiphospholipid Antibodies? / Philip G. de Groot, Elena Raschi, Keith R. McCrae, Silvia S. Pierangeli, Panayiotis G. Vlachoyiannopoulos, and Rolf T. Urbanus -- Part 3. 13th Iinternational Congress on Antiphospholid Antibodies Task Force Reports -- 7. Task Force Report on "Criteria" Antiphospholipid Antibody Tests / Robert A. S. Roubey and Silvia S. Pierangeli -- 8. Task Force Report on "Non-criteria" Antiphospholipid Antibody Tests / Maria Laura Bertolaccini, Olga Amengual, Tatsuya Atsumi, Walter L. Binder, William H. Kutteh, Bas de Laat, [and others] -- 9. Task Force Report on Obstetric Antiphospholipid Syndrome / D. Ware Branch, Benjamin Leader and Carl A. Laskin -- 10. Task Force Report on Brain Involvement in Antiphospholipid Syndrome / Joab Chapman, Eyal Muscal and Robin L. Brey -- 11. Task Force Report on the Management of Thrombosis in Antiphospholipid Syndrome / Guillermo Ruiz-Irastorza, Vittorio Pengo, Maria G. Tektonidou, Ioana Ruiz-Arruza, María José Cuadrado, and Munther A. Khamashta -- 12. Task Force Report on Catastrophic Antiphospholipid Syndrome / Gerard Espinosa, Horacio Berman, Doruk Erkan and Ricard Cervera -- 13. Task Force Report on Non-criteria Manifestations: Thrombocytopenia / Gabriela Hernández-Molina, Xavier López-Karpovitch, Emilio B. González and Antonio R. Cabral -- 14. Task Force Report on Non-criteria Manifestations: Nephropathy / Maria G. Tektonidou, Horacio E. Adrogué and Smita Vaidya -- 15. Task Force Report on Non-criteria Manifestations: Cardiac Valve Disease / Gerard Espinosa, Lucía Fernández de Orueta, Elena Lluch, María Ángeles Polvorosa, Sandra Soro, and Ricard Cervera -- 16. Task Force Report on Non-criteria Manifestations: Skin / Michal Solomon, Yehuda Shoenfeld and Gisele Zandman-Goddard -- 17. Task Force Report on Antiphospholipid Syndrome Clinical Research / Doruk Erkan, Silvia S. Pierangeli and Michael D. Lockshin -- Part 4. Future of Antiphospholipid Syndrome -- 18. What are the Potential Future Treatments in Antiphospholipid Syndrome? / Doruk Erkan, Anisur Rahman, Hannah Cohen, Samuel J. Machin and Silvia S. Pierangeli -- 19. Remembrances of Predictions Past / Michael D. Lockshin -- Part 5. Antiphospholipid Syndrome for Patients -- 20. What Should Patients Know about Antiphospholipid Antibodies and Antiphospholipid Syndrome? / Doruk Erkan, Lindsay Lally and Michael D. Lockshin.
  • 2010 Springer
    Bertolaccini, Marie Laura; Ateka-Barrutia, Oier; Khamashta, Munther A.
    History / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Epidemiology / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Antiphospholipid Antibodies / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Classification Criteria for APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Mortality, Morbidity, and Damage Associated with aPL / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differences Between Primary and Secondary APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Clinical Features / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- aPL and Transplantation / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differential Diagnosis / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Management of APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta.
  • 2009 ScienceDirect
    Cervera, Ricard; Khamashta, Munther A.; Reverter, Joan Carles.
  • 2006 Karger
    Elkon, Keith B.
    Death receptor signaling and its function in the immune system / Fas, S.C. ... [et al.] -- Inherited and acquired death receptor defects in human autoimmune lymphoproliferative syndrome / Rieux-Laucat, F. -- Tumor necrosis factor ligand-receptor superfamily and arthritis / Hsu, H.-C., Wu, Y., Mountz, J.D. -- Mitochondria, apoptosis and autoimmunity / Pinkoski, M.J., Waterhouse, N.J., Green, D.R. -- Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases / Hughes, P., Bouillet, P., Strasser, A. -- Mitochondria, cell death, and B cell tolerance / Deming, P.B., Rathmell, J.C. -- Role of complement and other innate immune mechanisms in the removal of apoptotic cells / Ogden, C.A., Elkon, K.B. -- Collectins: opsonins for apoptotic cells and regulators of inflammation / Stuart, L.M., Henson, P.M., Vandivier, R.W. -- MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure / Hanayama, R. ... [et al.] -- Clearance of apoptotic cells in human SLE / Gaipl, U.S. ... [et al.] -- Apoptosis and glomerulonephritis / Watson, S. ... [et al.].
  • 2008 Springer
    Bentley, Peter; Jung, Sungwon; Lee, Doheon.
  • 2010 CRCnetBASE
    Cruse, Julius M.; Lewis, R. E.
    History of immunology -- Molecules, cells, and tissues of the immune response -- Antigens and immunogens -- Major histocompatibility complex -- Antigen processing and presentation -- B lymphocyte development and immunoglobulin genes -- Immunoglobulin synthesis, properties, structure, and function -- Antigen-antibody interactions -- The thymus and T lymphocytes -- Cytokines and chemokines -- The complement system -- Types I, II, III, and IV hypersensitivity -- Immunoregulation and immunologic tolerance -- Autoimmunity -- Mucosal immunity -- Immunohematology -- Immunological diseases and immunopathology -- Immunophenotyping of hematopoietic malignancies -- Immunodeficiencies: congenital and acquired -- Acquired immune deficiency syndrome (AIDS) -- Immunomodulators -- Transplantation immunology -- Tumor immunology -- Immunity against microorganisms -- Vaccines and immunization -- Therapeutic immunology -- Comparative immunology -- Immunological methods and molecular techniques -- Diagnostic immunohistochemistry.
  • 2013 Springer
    Miranda, Roberto N.; Khoury, Joseph D.; Medeiros, L. Jeffrey.
    Atlas of Lymph Node Pathology reviews the histopathology of nodal diseases, illustrating the use of ancillary studies and includes concise discussions of pathogenesis, clinical settings and clinical significance of the pathologic diagnosis. The atlas features an overview of the benign reactive processes secondary to infectious, environmental or unknown insults, as well as relevant illustrations of virtually all primary and secondary neoplasms involving lymph nodes. The atlas also includes macroscopic images of some disorders, tables that help readers understand and comprehend diseases that look alike, and diagnostic algorithms for certain groups of diseases. Authored by highly experienced pathologists, Atlas of Lymph Node Pathology is a valuable resource that illustrates the vast majority of diseases practicing pathologists, clinicians and oncologists are likely to encounter in daily practice.
  • 2013 Springer
    O'Malley, Dennis P.
    1. Normal Morphologic and Immunohistochemical Findings and Hyperplasias -- 2. Congenital Malformations and Abnormalities of Spleen Location and Histology -- 3. Lmphoid Neoplasms -- 4. Myeloid and Related Disorders -- 5. Nonhematopoietic Lesions Including Vascular -- 6. Reactive and Systemic Conditions -- 7. Infections.
  • 2011 Karger
    Kiess, W.; Spergel, Jonathan M.; Werfel, Thomas.
    Atopic dermatitis is amongst the most common disorders of the skin in young people around the world. This book presents the newest insights and novel concepts in relation to all aspects of this skin disorder. Classification, clinical features and differential diagnosis are reviewed in the first chapter, while risk factors, susceptibility and an epidemiological overview are outlined in the next chapter, followed by a detailed discussion of the immunology of the skin and the pathophysiology of dermatitis. Further chapters present new data delineating clinical aspects of current genetic findings and insights into concepts of neuroimmunology, as well as the very crucial and severe clinical aspect of itching. New data on the topic of inhalant allergy, specific immunologic treatments and the latest on food allergy are also included.
  • 2010
    Ho, Lena Wai Mun; Cleary, Michael L.; Crabtree, Gerald R.; Scott, Matthew P.; Weissman, Irving L.
    Mammalian SWI/SNF (also called BAF) ATP-dependent chromatin remodeling complexes are essential for formation of the pluripotent cells of the early embryo, and are also crucial for the self-renewal and pluripotency of mouse embryonic stem cells (ESCs). To understand the molecular mechanism of BAF complexes in regulating the chromatin of pluripotent stem cells, we performed both proteomic and genomic studies of endogenous complexes in ESCs. Proteomic studies reveal that ESCs express distinctive BAF complexes (esBAF), and this specialized subunit composition is required for ESC maintenance and pluripotency. High-resolution genome-wide mapping of the core ATPase subunit, Brg, using ChIP-Seq technology indicates that esBAF is a core component of the pluripotent transcriptional network. This is consistent with findings that esBAF interacts both physically and genetically with key regulators of pluripotency such as Stat3, Oct4 and Sox2. In addition, esBAF is critical for Stat3-mediated gene activation and repression in mESCs in response to Leukemia Inhibitory Factor (LIF), the cytokine that maintains mESCs in a self-renewing state. Brg maintains open accessibility of Stat3 target sites to allow continuous binding of Stat3 in response to LIF signaling, and prevents the expansion of Polycomb activity and the inappropriate deposition of the silencing mark H3K27me3 at both Stat3 targets and other sites. We propose that one integral mechanism of esBAF action in maintaining pluripotency is to maintain Stat3 responsiveness in ESCs by regulating the accessibility of its target sites. The role of BAF complexes in self-renewal and differentiation extend to adult multipotent stem cells. Using mouse adult hematopoietic development as a model, we show that Brg is required for the transition of quiescent long-term hematopoietic stem cells (LT-HSCs) to their downstream progenitors, and for the multilineage differentiation of transit amplifying hematopoietic progenitors. Hence, we propose that chromatin remodeling is generally required for the function and maintenance of stem cells by the regulation of their specialized chromatin landscape.
  • 2010 CRCnetBASE
    Brown, W. Ted; Chauhan, Abha; Chauhan, Ved.
    Type, topography, and sequelae of neuropathological changes shaping clinical phenotype of autism / Jerzy Wegiel ... [et al.] -- Evidence for oxidative damage in the autistic brain / Teresa A. Evans ... [et al] -- Oxidative stress and neurotrophin signaling in autism / Elizabeth M. Sajdel-Sulkowska -- Genetics of autism / W. Ted Brown -- The phenotypic expression of autism, maternal depression, and the monoamine oxidase-a gene / Ira L. Cohen -- Paraoxonase 1 status, environmental exposures, and oxidative stress in autism spectrum disorders / Maria Dronca and Sergiu P. Pasca -- The redox/methylation hypothesis of autism : a molecular mechanism for heavy metal-induced neurotoxicity / Richard C. Deth -- Autism and oxidative stress : evidence from an animal model / Michelle A. Cheh ... [et al.] -- Neurotoxic brainstem impairment as proposed threshold event in autistic regression / Woody R. McGinnis ... [et al.] -- Abnormalities in membrane lipids, membrane-associated proteins, and signal transduction in autism / Ved Chauhan and Abha Chauhan -- Mitochondrial component of calcium signaling abnormality in autism / J. Jay Gargus -- Inflammation and neuroimmunity in the pathogenesis of autism : neural and immune network interactions / Carlos A. Pardo-Villamizar and Andrew W. Zimmerman -- Possible impact of innate immunity on autism / Harumi Jyonouchi -- Autism, gastrointestinal disturbance, and immune dysfunction : what is the link? / Paul Ashwood, Amanda Enstrom, and Judy van de Water -- Possible mechanism involving intestinal oxytocin, oxidative stress, and signaling pathways in a subset of autism with gut symptoms / Martha G. Welch and Benjamin Y. Klein -- Cytokine polymorphisms in autism : their role in immune alterations / Fabián Crespo ... [et al.] -- Autism, teratogenic alleles, HLA-DR4, and immune function / William G. Johnson ... [et al.] -- Autism : the centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy / Martha R. Herbert -- A re-evaluation of the state of autism treatment : the need for a biopsychosocial perspective / Eric London.
  • 2013 Springer
    Adams, Duncan Dartrey; Adams, Christopher Dartrey.
    This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
  • 2011 Springer
    Khamashta, Munther A.; Ramos-Casals, Manuel.
    Assessment and Management of the Rheumatological Patient in the Critical Care Unit -- Life-Threatening Complications of Systemic Lupus Erythematosus -- Catastrophic Antiphospholipid Syndrome -- Complex Situations in Rheumatoid Arthritis -- Sjögren's Syndrome: Beyond Sicca Involvement -- Systemic Sclerosis: Severe Involvement of Internal Organs -- Vasculitic Emergencies in Patients with Large-Vessel Vasculitis -- Life-Threatening Presentations of ANCA-Associated Vasculitis -- Severe Polyarteritis Nodosa -- Life-Threatening Cryoglobulinemia -- Behçets Syndrome: Clinical Presentations Affecting Prognosis and Survival -- Myositis: When Weakness Can Kill -- Complicated Sarcoidosis: Challenges in Dealing with Severe Manifestations -- Complex Situations in Patients with Adult-Onset Still's Disease -- Managing Acute and Complex Dermatological Situations -- Life-Threatening Autoimmune Hematological Disorders -- Autoimmune Ear, Nose, and Throat Emergencies -- Ophthalmological Emergencies in Rheumatic and Autoimmune Diseases -- Emergencies for the Vascular Surgeon -- Complicated Pregnancies in Patients with Autoimmune Systemic Diseases -- The Complex Management of Viral-Related Autoimmune Diseases -- The Role of Intravenous Immunoglobulins in the Management of Acute Complex Autoimmune Conditions -- Life-Threatening Complications of Biological Therapies.
  • 2014 ScienceDirect
    2014 ClinicalKey
    Mackay, Ian R.; Rose, Noel R.
  • 2011 Springer
    Hertl, Michael.
    Pathogenesis of autoimmune diseases / Martin Röcken and Tilo Biedermann -- Autoantibody detection using indirect immunofluorescence on HEp-2 cells / Philipp von Landenberg -- Pemphigus / Michael Hertl and Rüdiger Eming -- Bullous pemphigoid : clinical features, diagnostic markers, and immunopathogenic mechanisms / Giovanni Di Zenzo ... [et al.] -- Dermatitis herpetiformis duhring / Christian Rose and Detlef Zillikens -- Epidermolysis bullosa acquisita / Gene Kim ... [et al.] -- Localized scleroderma / Cristián Vera Kellet, Catherine H. Orteu, and Jan P. Dutz -- Progressive systemic scleroderm / Nicolas Hunzelmann and Thomas Krieg -- Chronic cutaneous lupus erythematosus / Michael Sticherling -- Subacute cutaneous and systemic lupus erythematosus / Donna M. Pellowski, Jane E. Kihslinger, and Richard D. Sontheimer -- Dermatomyositis / Ruth Ann Vleugels and Jeffrey P. Callen -- Mixed connective tissue disease / Reiji Kasukawa -- Sjögren's Syndrome / Robert I. Fox and Carla M. Fox -- Psoriasis vulgaris and arthopathica / Arnd Jacobi and Jörg Christoph Prinz -- Chronic urticaria as an autoimmune disease / Clive Grattan, Michihiro Hide, and Malcolm W. Greaves -- Lichen planus, lichenoid eruptions and cutaneous grant-versus-host-reaction / Miklós Simon, Jr. -- Small vessel vasculitides / Peter Lamprecht and Wolfgang L. Gross -- Skin manifestations of rheumatic diseases / Camille Francés and Nicolas Kluger -- Vitiligo / Karin U. Schallreuter -- Alopecia areata / Pia Freyschmidt-Paul, Kevin McElwee, and Rolf Hoffmann -- Autoimmune phenomena in atopic dermatitis / Caroline Bussmann and Natalija Novak -- Eosinophils in autoimmune bullous diseases / Dagmar Simon and Hans-Uwe Simon -- Paraneoplastic syndromes of the skin / Peter Fritsch -- Targeted therapies in autoimmune and inflammatory skin disorders / Rüdiger Eming and Ingo H. Tarner.
  • 2006 ScienceDirect
    Mackay, Ian R.; Rose, Noel R.
    Also available: Print – 2006
  • 2014 Springer
    Ohira, Hiromasa.
    Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
  • 2015 Springer
    Chung, Jae Bock; Kamisawa, Terumi.
    This book provides up-to-date information on all aspects of autoimmune pancreatitis, a unique form of pancreatitis characterized clinically by frequent presentation with obstructive jaundice and dramatic response to steroids, histologically by a lymphoplasmacytic infiltrate with fibrosis, and radiologically by pancreatic enlargement. Current concepts regarding the disease and its classification into subtypes 1 and 2 are explained, and clinical, serological, and histopathological findings are carefully described. Imaging features on all the relevant modalities are illustrated, covering both the pancreas and other involved organs. Current and emerging therapeutic strategies, including steroids, immunomodulatory drugs, and rituximab, are then discussed. The reader will find the book to be an excellent aid to the diagnosis of autoimmune pancreatitis and its differentiation from pancreatobiliary malignancies, as well as a clear guide to treatment.
  • 2012 Springer Protocols
    Perl, Andras.
    Pathogenesis and spectrum of autoimmunity / Andras Perl -- Mapping susceptibility gene in systemic lupus erythematosus / R. Hal Scofield and Kenneth M. Kaufman -- Methods and protocols to study T cell signaling abnormalities in human systemic lupus erythematosus / Vaishali R. Moulton, Mindy S. Lo, and George C. Tsokos -- Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus / Andras Perl, Robert Hanczko, and Edward Doherty -- Role of endocytic recycling in autoimmunity / Tiffany Telarico and Andras Perl -- Multiparameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus / Denise A. Kaminski [and others] -- Experimental use of mouse models of systemic lupus erythematosus / Stanford L. Peng -- Murine models of lupus induced by hypomethylated T cells (DNA hypomethylation and lupus ...) / Bruce Richardson [and others] -- Aspects of CNS lupus : mouse models of anti-NMDA receptor antibody mediated reactivity / Czeslawa Kowal and Betty Diamond -- Analysis of renal mononuclear phagocytes in murine models of SLE / Ramalingam Bethunaickan, Ranjit Sahu, and Anne Davidson -- Murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21 / Partha S. Biswas [and others] -- Parent-into-F1 murine model in the study of lupus-like autoimmunity and CD8 cytotoxic T lymphocyte function / Kateryna Soloviova [and others] -- Genetic approach to study lupus glomerulonephritis / Yan Ge [and others] -- Animal models of primary biliary cirrhosis : materials and methods / Patrick S.C. Leung [and others] -- Modeling innate immunity in murine skin : utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease / Michael Dimarzio, Giuseppina Farina, and Robert Lafyatis -- Flow cytometric identification of fibrocytes in scleroderma lung disease / Thomas M. Russell, Erica L. Herzog, and Richard Bucala -- Oxidative stress and beta cell dysfunction / Yaima L. Lightfoot, Jing Chen, and Clayton E. Mathews -- Experimental autoimmune encephalomyelitis / Praveen Rao and Benjamin M. Segal -- Mouse models of multiple sclerosis : experimental autoimmune encephalomyelitis and theiler's virus-induced demyelinating disease / Derrick P. McCarthy, Maureen H. Richards, and Stephen D. Miller -- Pathogenesis of multiple sclerosis : what can we learn from the cuprizone model / Peter Acs and Bernadette Kalman -- Assessing inflammatory disease at mucosal surfaces in murine genetic models / R.W. Engelman and William G. Kerr -- Rodent models of experimental autoimmune uveitis / Rajeev K. Agarwal, Phyllis B. Silver, and Rachel R. Caspi -- Tolerance induction via B-cell delivered gene therapy / Robert J. Rossi [and others].
  • 2008 Springer Protocols
    Deretic, Vojo.
    Autophagosome and phagosome / V. Deretic -- Fine structure of the autophagosome / E.L. Eskelinen -- Methods for assessing autophagy and autophagic cell death / E. Tasdemir ... [et al.] -- LC3 and Autophagy / I. Tanida, T. Ueno and E. Kominami -- Amino Acid regulation of autophagosome formation / A.J. Meijer -- Autophagic proteolysis of long-lived proteins in nonliver cells / E.A. Roberts and V. Deretic -- Autophagosomes in GFP-LC3 Transgenic Mice / N. Mizushima and A. Kuma -- Experimental control and characterization of autophagy in Drosophila / G. Juhasz and T.P. Neufeld -- Analysis of autophagosome membrane cycling by fluorescence microscopy / J.E. Legakis and D.J. Klionsky -- Protein trafficking into autophagosomes / A. Young and S. Tooze -- Sphingolipids in macroautophagy / G. Lavieu ... [et al.] -- Molecular links between autophagy and apoptosis / I.A. Ciechomska, C.G. Goemans and A.M. Tolkovsky -- Clearance of mutant aggregate-prone proteins by autophagy / B. Ravikumar, S. Sarkar and D.C. Rubinsztein -- Localization and MHC Class II Presentation of Antigens Targeted for Macroautophagy / D. Schmid and C. Munz -- Chaperone-mediated autophagy / S. Kaushik and A.M. Cuervo -- Microautophagy in the Yeast Saccharomyces cerevisiae / A. Uttenweiler and A. Mayer -- EM Analysis of Phagosomes / C. de Chastellier -- Analysis of phosphoinositide dynamics during phagocytosis using genetically encoded fluorescent biosensors / G. Cosio and S. Grinstein -- In vitro phagosome-endosome fusion / I. Vergne and V. Deretic -- Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome / R.M. Yates and D.G. Russell -- Maturation changes in purified phagosomes / R. Dieckmann ... [et al.] -- Large-scale purification of latex bead phagosomes from mouse macrophage cell lines and subsequent preparation for high-throughput quantitative proteomics / A. Rupper and J. Cardelli -- Class II MHC Antigen Processing in Phagosomes / L. Ramachandra, W.H. Boom and C.V. Harding -- Analyzing Association of the Endoplasmic Reticulum with the Legionella pneumophila-Containing Vacuoles by Fluorescence Microscopy / A. Ingmundson and C.R. Roy -- Fractionation of the Coxiella burnetii Parasitophorous Vacuole / D. Howe and R.A. Heinzen -- Bacterial Phagosome Acidification Within IFN-gamma-Activated Macrophages: Role of Host p47 Immunity-Related GTPases (IRGs) / S. Tiwari and J.D. Macmicking -- SopE-Mediated Recruitment of Host Rab5 on Phagosomes Inhibits Salmonella Transport to Lysosomes / R. Madan, G. Krishnamurthy and A. Mukhopadhyay -- The Mycobacterium tuberculosis Phagosome / E.A. Roberts and V. Deretic.
  • v. 1-, 2014 ScienceDirect
    v. 2, 2014 ScienceDirect
    v.3, 2014 ScienceDirect
    Hayat, M. A.
    Volume 1. Molecular mechanisms -- Volume 2. Role in general diseases -- Volume 3. Mitophagy.
  • 2009 Springer
    Deretic, Vojo; Levine, Beth; Yoshimori, Tamotsu.
    Also available: Print – 2009
  • 2015 Wiley
    Jackson, William T.; Swanson, Michele.
    Autophagy and immunity / Xu Liu and Daniel J. Klionsky -- Techniques for studying autophagy / Isei Tanida and Masato Koike -- Role of autophagy in DNA virus infections in vivo / Xionan Dong and Beth Levine -- Studying RNA viruses and autophagy in vivo / Mehrdad Alirezaei and J. Lindsay Whitton -- Autophagy and picornavirus infection / Tom Wileman, Zhigang Zhou, Matthew Whelband, Eleanor Cottam, Stephen Berryman, Terry Jackson, and Rebecca Roberts -- Flaviviruses and autophagy / Tristan X. Jordan and Glenn Randall -- Autophagy : a home remodeler for Hepatitis C virus / Marine L.B. Hillaire, Elodie Decembre, and Marlene Dreux -- Modulating autophagy to cure Human Immunodeficiency Virus type-1 / Stephen A. Spector and Grant R. Campbell -- Autophagy in the infected cell : insights from pathogenic bacteria / Andrea Sirianni and Serge Mostowy -- Rab proteins in autophagy: streptococcus model / Ichiro Nakagawa -- Helicobacter pylori infection control by autophagy / Laura K. Greenfield, Frances Dang, and Nicola L. Jones -- Interactions between salmonella and the autophagy system / Teresa L.M. Thurston and David W. Holden -- Host factors that recruit autophagy as defense against toxoplasma gondii / Carlos S. Subauste -- Mycobacterium tuberculosis and the autophagic pathway / Gabriela María Recalde and María Isabel Colombo -- Autophagy enhances the efficacy of BCG vaccine / Arshad Khan, Christopher R. Singh, Emily Soudani, Pearl Bakhru, Sankaralingam Saikolappan, Jeffrey D. Cirillo, N. Tony Eissa, Subramanian Dhandayuthapani, and Chinnaswamy Jagannath -- Autophagy's contribution to innate and adaptive immunity : an overview / Christina Bell, Michel Desjardins, Pierre Thibault, and Kerstin Radtke -- Autophagy in immune responses to viruses / Christophe Viret and Mathias Faure -- Processing and MHC presentation of antigens after autophagy-assisted endocytosis, exocytosis and cytoplasm degradation / Christian Münz.
  • 2014 ScienceDirect
    Kaiser, P.; Kaspers, Bernd; Schat, K. A.
    Provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, this book encompasses all aspects of innate and adaptive immunity in chickens.
  • 2016 Springer
    Kurosaki, Tomo; Wienands, Jürgen.
    Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.
  • 2005 Karger
    Stohl, William.
    Determinations of B cell fate in immunity and autoimmunity / Noelle, R.J.; Erickson, L.D. -- Regulatory roles for cytokine-producing B cells in infection and autoimmune disease / Lund, F.E. ... [et al.] -- The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease / Tedder, T.F. ... [et al.] -- Marginal zone B cell physiology and disease / Lopes-Carvalho, T.; Kearney, J.F. -- Dendritic cells control B cell growth and differentiation / Jego, G. ... [et al.] -- The biology of CD20 and its potential as a target for mAb therapy / Cragg, M.S. ... [et al.] -- B lymphocyte depletion in rheumatoid arthritis / Edwards, J.C.W.; Leandro, M.J.; Cambridge, G. -- Treatment of SLE with anti-CD20 monoclonal antibody / Looney, R.J.; Anolik, J.; Sanz, I. -- The biochemistry and biology of BAFF, APRIL and their receptors / Kalled, S.L.; Ambrose, C.; Hsu, Y.-M. -- The BAFF/APRIL system / Mackay, F. ... [et al.] -- Human B lymphocyte malignancies / Jelinek, D.F.; Darce, J.R. -- BlySfulness does not equal blissfulness in systemic lupus erythematosus / Stohl, W.
  • 2016 Springer Protocols
    Fauvart, Maarten; Michiels, Jan.
    Historical perspective on bacterial persistence / Natalie Verstraeten ... [et al.] -- Persisters : methods for isolation and identifying contributing factors-a review / Sarah E. Rowe ... [et al.] -- General method for measuring persister levels in Escherichia coli cultures / Niilo Kaldalu ... [et al.] -- Optimized method for measuring persistence in Escherichia coli with improved reproducibility / F. Goormaghtigh and L. Van Melderen -- Microplate-based system as in vitro model of biofilm growth and quantification / Ilse Vandecandelaere, Heleen Van Acker, and Tom Coenye -- Protocol for determination of the persister subpopulation in Candida Albicans biofilms / Katrijn De Brucker ... [et al.] -- Quantitative measurements of type I and type II persisters using ScanLag / Irit Levin-Reisman and Nathalie Q. Balaban -- Analyzing persister physiology with fluorescence-activated cell sorting / Mehmet A. Orman ... [et al.] -- Single-cell detection and collection of persister bacteria in a directly accessible femtoliter droplet array / Ryota Iino ... [et al.] -- Whole-cell-based high-throughput screening method to identify molecules targeting Pseudomonas Aeruginosa persister cells / Veerle Liebens, Valerie Defraine, and Maarten Fauvart -- Functional analysis of the role of toxin-antitoxin (TA) loci in bacterial persistence / Aaron T. Butt and Richard W. Titball -- Experimental evolution of Escherichia coli persister levels using cyclic antibiotic treatments / Bram Van den Bergh, Joran E. Michiels, and Jan Michiels -- In vitro models for the study of the intracellular activity of antibiotics / Julien M. Buyck ... [et al.] -- Murine model for Escherichia coli urinary tract infection / Thomas J. Hannan and David A. Hunstad -- Analysis of macrophage-induced Salmonella persisters / Robert A. Fisher, Angela M. Cheverton, and Sophie Helaine -- Population dynamics analysis of ciprofloxacin-persistent S. Typhimurium cells in a mouse model for Salmonella diarrhea / Patrick Kaiser, Roland R. Regoes, and Wolf-Dietrich Hardt -- Computational methods to model persistence / Alexandra Vandervelde ... [et al.].
  • 2009 ClinicalKey
    Peakman, Mark; Vergani, Diego.
    Anatomy and cells of the immune system -- Innate immunity I: physical and humoral protection -- Innate immunology II: cellular mechanisms -- Acquired immunity: antigen receptors -- The human leukocyte antigens -- Cellular immune responses I: dendritic cells, macrophages and B lymphocytes -- Cellular immune responses II: T lymphocytes, antigen presentation and natural killer cells -- The immune response to microbes: an overview -- Tolerance and mechanisms of autoimmunity -- Hypersensitivity reactions and clinical allergy -- Transplantation -- Rheumatic diseases -- Endocrine autoimmune disease -- Liver diseases -- Gastrointestinal diseases -- Immune-mediated nephritis and vasculitis -- Immune-mediated skin disease -- Immune-mediated diseases of the nervous system and eye -- Immunodificiency -- Human immunodeficiency virus and AIDS -- Immunological manifestations of haematological disease -- Immune-based therapies -- Immunisation.
  • 2016 ClinicalKey
    Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv.
    Introduction to the immune system : nomenclature, general properties, and components -- Innate immunity : the early defense against infections -- Antigen capture and presentation to lymphocytes : what lymphocytes see -- Antigen recognition in the adaptive immune system : structure of lymphocyte antigen receptors and development of immune repertoires -- T cell-mediated immunity : activation of t lymphocytes by cell-associated antigens -- Effector mechanisms of t cell-mediated immunity : functions of t cells in host defense -- Humoral immune responses : activation of b lymphocytes and production of antibodies -- Effector mechanisms of humoral immunity : elimination of extracellular microbes and toxins -- Immunological tolerance and autoimmunity : self-nonself discrimination in the immune system and its failure -- Immune responses against tumors and transplants : immunity to noninfectious transformed and foreign cells -- Hypersensitivity : disorders caused by immune responses -- Congenital and acquired immunodeficiencies : diseases caused by defective immunity.
  • 2014 Springer Protocols
    Falcone, Franco H.; Gibbs, Bernhard F.
    Paradigm shifts in mast cell and basophil biology and function : an emerging view of immune regulation in health and disease / Ana Olivera and Juan Rivera -- Purification of basophils from peripheral human blood / Franco H. Falcone and Bernhard F. Gibbs -- Mast cell purification protocols / Jasmine Farrington , Elizabeth P. Seward , and Peter T. Peachell -- Generation of a human allergic mast cell phenotype from CD133+ stem cells / Hans Jürgen Hoffmann -- Generation of mast cells from murine stem cell progenitors / Emily J. Swindle -- Integration of the human dermal mast cell into the organotypic co-culture skin model / Jonghui Kim [and four others] -- The absolute basophil count / Elena Borzova and Clemens A. Dahinden -- Mast cell and basophil cell lines : a compendium / Egle Passante -- Detection of mast cells and basophils by immunohistochemistry / Andrew F. Walls and Cornelia Amalinei -- Measuring histamine and cytokine release from basophils and mast cells / Bettina M. Jensen, Sidsel Falkencrone, and Per S. Skov -- Flow cytometric allergy diagnosis : basophil activation techniques / Chris H. Bridts [and five others] -- Microscopy assays for evaluation of mast cell migration and chemotaxis / Monika Bambousková [and three others] -- Use of humanized rat basophil leukemia (RBL) reporter systems for detection of allergen-specific IgE sensitization in human serum / Daniel Wan [and four others] -- Gene silencing approaches in mast cells and primary human basophils / Vadim V. Sumbayev and Bernhard F. Gibbs -- Basophil stimulation and signaling pathways / Edward F. Knol and Bernhard F. Gibbs -- Identification and immunophenotypic characterization of normal and pathological mast cells / José Mário Morgado [and three others] -- Identification of murine basophils by flow cytometry and histology / Christian Schwartz and David Voehringer -- Mast cell-mediated reactions in vivo / Vladimir Andrey Giménez-Rivera , Martin Metz, and Frank Siebenhaar.
  • 2015 Springer
    Ishigatsubo, Yoshiaki.
    This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
  • 2014 Springer
    Emmi, Lorenzo.
    1. The Numbers of Behçet: A Rare Disease? / Agata Polizzi and Domenica Taruscio -- 2. From Hippocrates to Hulusi Behçet: What History / Donatella Lippi -- 3. Epidemiology of Behçet Syndrome / Olga Addimanda, Giulia Pazzola, Nicolò Pipitone and Carlo Salvarani -- 4. Behçet's Syndrome According to Classical and Population Genetics / Akira Meguro, Nobuhisa Mizuki, Ahmet Gül, Nobuyoshi Kitaichi and Shigeaki Ohno -- 5. Infections, Autoimmunity, and Behçet's Syndrome: What Liaison? / Mario Milco D'Elios, Marisa Benagiano, Amedeo Amedei and Giacomo Emmi -- 6. Pathogenesis of Behçet Syndrome / Giacomo Emmi, Danilo Squatrito, Elena Silvestri, Alessia Grassi and Lorenzo Emmi -- 7. Mucocutaneous Involvement in Behçet's Syndrome / Umit Tursen -- 8. Neurological and Neuropsychological Manifestation in Behçet's Syndrome / Shunsei Hirohata -- 9. Ocular Involvement and Behçet Disease / Lorenzo Vannozzi, Ugo Menchini and Massimo Accorinti -- 10. Articular and Muscular Manifestations in Behçet's Disease / Anne-Claire Desbois, Betrand Wechsler and David Saadoun -- 11. Cardiovascular Issues: Aneurysms and Pseudoaneurysms, Thrombosis, Atherosclerosis, and Cardiac Involvement / Elena Silvestri, Caterina Cenci, Chiara Della Bella, Anna Maria Cameli and Domenico Prisco -- 12. Intestinal Behçet Disease / Cristina Cenci and Monica Milla -- 13. Audio Vestibular Involvement in Behçet's Disease / Paolo Vannucchi and Rudi Pecci -- 14. Behçet's Syndrome and Gynecological Manifestation in Reproductive Age and Pregnancy / Maria Elisabetta Coccia and Tommaso Capezzuoli -- 15. Pediatric Onset of Behçet Syndrome / Ezgi Deniz Batu, Rolando Cimaz and Seza Özen -- 16. Behçet's Disease. Differential Diagnosis / Maria Grazia Sabbadini and Stefano Franchini -- 17. Classification and Diagnosis Criteria for Behçet's Disease / Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams and Abdolhadi Nadji -- 18. Prognosis and Disease Activity / Rosaria Talarico, Anna d'Ascanio, Rossella Neri, Chiara Baldini, Marta Mosca and Stefano Bombardieri -- 19. Old and New Treatment for Behçet's Disease / Fabrizio Cantini and Gerardo Di Scala -- 20. Surgical Treatment of Angio-Behçet / Stefano Camparini and Genadi Genadiev.
  • 2013 Springer
    Dobrindt, Ulrich; Hacker, Jörg; Svanborg-Edén, Catharina.
    E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity / Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt -- What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? / Ralf Rosenstein, Friedrich Götz -- Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung / Michael Hogardt, Jürgen Heesemann -- Lactobacillus: Host-Microbe Relationships / John O'Callaghan, Paul W. O'Toole -- Bacterial Moonlighting Proteins and Bacterial Virulence / Brian Henderson, Andrew Martin -- Symbionts and Pathogens: What is the Difference? / Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya -- Ecology and Physiology of the Intestinal Tract / Michael Blaut -- The Gut Microflora and Its Variety of Roles in Health and Disease / Julia-Stefanie Frick, Ingo B. Autenrieth -- Host-Recognition of Pathogens and Commensals in the Mammalian Intestine / Oriana Rossi, Peter van Baarlen, Jerry M. Wells -- Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age / Jing Cheng, Airi M. Palva, Willem M. de Vos.
  • 2010 Springer
    Davies, Matthew; Flower, Darren R.; Ranganathan, Shoba.
  • 2014 ScienceDirect
    Ishii, Ken J.; Tang, Choon Kit.
    Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
  • 2006
  • 2016 Springer
    Montoya, Ivan D.
    Introduction -- PART I: Vaccines: Introduction -- Nicotine -- Cocaine -- Heroin -- Metamphetamine -- PART II: Monoclonal antibodies: Introduction -- Cocaine -- Metamphetamine -- PCP -- PART III: Enzymes: Introduction -- Butyrylcholinesterase -- Cocaine Esterase -- PART IV: New strategies to optimize the development of biologics: Adenovirus based vaccines -- Nanotechnology based vaccines -- Protein Nanoparticles -- DNA Scaffolded Vaccines -- Single Hapten Conjugate Therapeutic Vaccine -- Vaccine Adjuvants -- Laser Adjuvant -- Peptide Conjugates & Cytokine Adjuvants -- T. brucei: A Platform for Immunization -- Vaccines for SUDs and HIV infection -- New Monoclonal Antibodies -- Protein Engineered for Controlled Duration of Action -- PART V: Ethical aspects of biologics to treat SUDs.
  • 2011 Springer
    Kontermann, Roland.
    "The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A deeper understanding of effector cell biology and especially developments in the field of antibody engineering has led to the generation of new classes of bispecific antibodies capable of circumventing many of these obstacles. Furthermore, new applications were established for bispecific antibodies, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies, but also on emerging applications such as dual targeting strategies, i.e., the simultaneous inhibition of two targets (cytokines, receptors, etc.) are provided. This book is intended for a broad readership in the field of antibody engineering, mainly from the pharmaceutical and biotechnology sector, but also including academic researchers working in this field."--Publisher's website.
  • 2014 Springer Protocols
    Beksac, Meral.
    Reporter Gene Technologies for Imaging Cell Fates in Hematopoiesis / Sophie Kusy and Christopher H. Contag -- Flow Cytometry for Hematopoietic Cells / Daniela S. Krause, Michelle E. DeLelys, and Frederic I. Preffer -- Isolation and Characterization of Mesenchymal Stem Cells / Sedat Odabas, A. Eser Elçin, and Y. Murat Elçin -- Methods for Functional Analysis of Stem Cells / Michelle Escobedo-Cousin, J. Alejandro Madrigal, and Aurore Saudemont -- An Overview of HLA Typing for Heamatopoietic Stem Cell Transplantation / Katy Latham, Ann-Margaret Little, and J. Alejandro Madrigal -- HLA Typing with Sequence-Specific Oligonucleotide Primed PCR (PCR-SSO) and Use of the Luminex Technology / Klara Dalva and Meral Beksaç -- Sequence Based Typing of HLA: An Improved Group Specific Full Length Gene Sequencing Approach / Christina E.M. Voorter, Fausto Palusci, and Marcel G.J. Tilanus -- Molecular Typing Methods for Minor Histocompatibility Antigens / Eric Spierings -- Natural Killer Cells and Killer-cell Immunoglobulin-like Receptor Polymorphisms: Their Role in Hematopoietic Stem Cell Transplantation / Jennifer Schellekens, Katia Gagne, and Steven G.E. Marsh -- Methods of Detection of Immune Reconstitution and T Regulatory Cells by Flow Cytometry / Richard Charles Duggleby and J. Alejandro Madrigal -- Molecular Methods Used for Detection of Minimal Residual Disease Following Hematopoietic Stem Cell Transplantation in Myeloid Disorders / Ahmet H. Elmaagacli -- Molecular Methods for Detection of Minimal Residual Disease Following Transplantation in Lymphoid and Plasma Cell Disorders / Paolo Corradini and Cristiana Carniti -- Molecular Methods for Detection of Invasive Fungal Infections and Mycobacteria and Their Clinical Significance in Hematopoietic Stem Cell Transplantation / Pinar Yurdakul and Sule Colakoglu -- Post-transplant Monitoring of Chimerism by Lineage-specific Analysis / Sandra Preuner and Thomas Lion -- Urinary Proteomics Employing Capillary Electrophoresis Coupled to Mass Spectrometry in The Monitoring Of Patients After Stem Cell Transplantation / Eva M. Weissinger, William Mullen, and Amaya Albalat.
  • 2007 Springer Protocols
    Beksac, Meral.
  • 2013 Springer
    Binz, Thomas; Rummel, Andreas.
    The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
    Also available: Print – 2013
  • 2012 Springer
    Galoyan, Armen.
    The Cytokine System -- The Discovery of the Brain Immunomodulators -- Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines Produced by NSO and NPV of Hypothalamus -- Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action -- Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin -- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection with Proline-Rich Polypeptides Galarmin and Its Structural Analogues in an Experimental Murine Model -- Treatment of Clostridium Perfringens-induced Gas Gangrene by New Cytokines of Brain -- Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection -- Brain-Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone Marrow Progenitor cells -- Antioxidant-Antiradical and Electron Donating Function of Galarmin and Gx-NH2 -- Discussion -- Summary.
  • 2011 Springer
    Albertson, Timothy Eugene; Gershwin, M. Eric.
  • 2010 Springer
    Jensen-Jarolim, Erika; Penichet, Manuel L.
  • 2014 Wiley
    Hiraku, Yūsuke; Kawanishi, Shōsuke; Ōshima, Hiroshi.
    Infection, inflammation, and cancer: overview / Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu Tomono -- Stem cell theory and inflammation-related cancer / Toshihiko Tanno and William Matsui -- Epithelial-mesenchymal transition: a link between cancer and inflammation / Jonas Fuxe and Mikael C.I. Karlsson -- Role of nitrative DNA damage in inflammation-related carcinogenesis / Yusuke Hiraku and Shosuke Kawanishi -- Lipid peroxidation-derived DNA adducts and the role in inflammation-related carcinogenesis / Helmut Bartsch and Urmila Jagadeesan Nair -- Level of inflammation-related DNA adducts in human tissues / Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko Sugimura -- Toll-like receptors: role in inflammation and cancer / Sarang Tartey and Osamu Takeuchi -- Inflammasomes and inflammation / Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, and Kate Schroder -- Activation-induced cytidine deaminase: an intrinsic genome modulator in inflammation-associated cancer development / Hiroyuki Marusawa and Tsutomu Chiba -- MicroRNA and inflammation-related cancer / Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian Ma, Ming Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and Guiyuan Li -- Inflammation as a niche for tumor progression / Futoshi Okada -- Human papillomavirus and cervical cancer / Kurt J. Sales -- Hepatitis viruses and hepatocellular carcinoma / Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen -- Epstein-Barr virus and nasopharyngeal carcinoma / Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and Zhe Zhang -- Barrett's esophagus and esophageal cancer / Albert Roessner and Angela Poehlmann -- Asbestos-induced chronic inflammation and cancer / Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, and Haining Yang -- Nanomaterials / Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei Zhang -- Inflammatory pathways of radiation-induced tissue injury / Danae A. Laskaratouu, Ifigeneia V. Mavragani, and Alexandros G. Georgakilas -- Photocarcinogenesis and inflammation / Chikako Nishigori -- Chemoprevention of colorectal cancer by anti-inflammatory agents / Michihiro Mutoh, Mami Takahasi, and Keiji Wakabayashi -- Nutraceuticals and colon cancer prevention / Deepak Poudyal and Lorne J. Hofseth -- Cancer chemoprevention by targeting cox-2 using dietary phytochemicals / Kyung-Soo Chun and Young-Joon Surh -- Regulation of inflammation-associated intestinal diseases with phytochemicals / Akira Murakami.
  • 2015 Springer
    Rezaei, Nima.
    Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.
  • 2015 Springer
    Rezaei, Nima.
    Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.
  • 2011 Springer
    Dranoff, Glenn.
    Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
    Also available: Print – 2011
  • 2015 Springer
    Rezaei, Nima.
    This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗ℓ The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
  • 2014 Springer
    Britten, Cedrik Michael; Diken, Mustafa; Kreiter, Sebastian; Rammensee, Hans-Georg.
    This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • 2014 Springer Protocols
    Lawman, Michael J. P.; Lawman, Patricia D.
    Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules -- Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine -- Pulsing Dendritic Cells with Whole Tumor Cell Lysates -- Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy -- Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens -- Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma -- Dendritic Cells Primed with Protein-Protein Fusion Adjuvant -- Antigen-Specific mRNA Transfection of Autologous Dendritic Cells -- Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material -- Dendritic Cells Transfected with Adenoviral Vectors as Vaccines -- Genetic Modification of Dendritic Cells with RNAi -- Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy -- Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation -- Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines -- Modification of T Lymphocytes to Express Tumor Antigens -- Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor -- Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors -- Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients -- Cytokine Activation of Natural Killer Cells -- Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation -- Autologous Tumor Cells Engineered to Express Bacterial Antigens -- Tumor Cell Transformation Using Antisense Oligonucleotide -- The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy -- Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine -- Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography -- Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu -- TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens -- Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens -- Preparation of Polypeptides Comprising Multiple TAA Peptides -- Idiotype Vaccine Production Using Hybridoma Technology -- Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens -- Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule -- Bacterial Vectors for the Delivery of Tumor Antigens -- Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides -- Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells -- Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection -- The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy -- Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines -- Challenges Facing the Development of Cancer Vaccines -- Future of Cancer Vaccines.
  • 2015 Springer Protocols
    Lepenies, Bernd.
    Carbohydrate-based vaccines : an overview / Julia Hütter and Bernd Lepenies -- Glycans as vaccine antigens and adjuvants : immunological considerations / Stephanie Zimmermann and Bernd Lepenies -- Glycan array platform as a tool to identify carbohydrate antigens / Li Xia and Jeffrey C. Gildersleeve -- Antibody-carbohydrate recognition from docked ensembles using the AutoMap procedure / Tamir Dingjan, Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev -- Generation of monoclonal antibodies against defined oligosaccharide antigens / Felix Broecker, Chakkumkal Anish, and Peter H. Seeberger -- Murine whole-blood opsonophagocytosis assay to evaluate protection by antibodies raised against encapsulated extracellular bacteria / Guillaume Goyette-Desjardins, René Roy, and Mariela Segura -- Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility / David Bitto, David J. Harvey, Steinar Halldorsson, Katie J. Doores, Laura K. Pritchard, Juha T. Huiskonen, Thomas A. Bowden, and Max Crispin -- N-glycosylation fingerprinting of viral glycoproteins by xCGE-LIF / René Hennig, Erdmann Rapp, Robert Kottler, Samanta Cajic, Matthias Borowiak, and Udo Reichl -- Temporary conversion of protein amino groups to azides : a synthetic strategy for glycoconjugate vaccines / Tomasz Lipinski and David R. Bundle -- Gold nanoparticles as carriers for synthetic glycoconjugate vaccines / Fabrizio Chiodo and Marco Marradi -- Identification and characterization of carbohydrate-based adjuvants / Timo Johannssen and Bernd Lepenies -- Characterization of carbohydrate vaccines by NMR spectroscopy / Francesco Berti and Neil Ravenscroft -- Characterization of capsular polysaccharides and their glycoconjugates by hydrodynamic methods / Stephen E. Harding, Ali Saber Abdelhameed, Richard B. Gillis, Gordon A. Morris, and Gary G. Adams -- Glycoconjugate vaccines : the regulatory framework / Christopher Jones.
  • 2012
    Geha, Raif S.; Notarangelo, Luigi.
    Status: Not Checked OutLane Catalog Record
  • c2012
    Geha, Raif; Notarangelo, Luigi.
    Status: Not Checked OutLane Catalog Record
  • 2008
    Geha, Raif S.; Rosen, Fred S.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    Chen, Lieping.
  • 2011
    Alonso, Michael Nathaniel; Engleman, Edgar G.; Lee, Peter P.; Negrin, Robert S.; Utz, Paul J.
    Monocytes rapidly infiltrate inflamed tissues and differentiate into inflammatory dendritic cells (DCs) that mediate pathogen clearance. However, the cellular and molecular mechanisms governing inflammatory DC formation and subsequent function remain elusive. Current evidence suggests that conserved molecular patterns present on different classes of microbes that engage pattern recognition receptors on DCs dictate the type of immune response initiated by DCs. Given that pathogens are under evolutionary pressure to avoid elimination, we reasoned that memory T cells were better positioned to inform the immune response. The studies presented in this dissertation indicate that memory T cells dictate the nature of the immune response through the induction of functionally specialized inflammatory DCs. Our studies indicate that T-helper (TH) cells interact with monocytes in inflamed tissues and instruct monocytes to differentiate into inflammatory DCs in vivo. This process is antigen-driven and requires cell contact, GM-CSF and TNF[alpha]. Interestingly, distinct TH cell subsets direct the formation of specialized DC subsets. In psoriasis lesions, TH1 and TH17 cells interact with monocytes and instruct these cells to differentiate into TH1- and TH17-promoting DCs, respectively. Correspondingly, in acute atopic dermatitis, TH2 cells interact with monocytes and elicit the formation of TH2-promoting DCs. Again, DC formation required GM-CSF and cell contact, whereas TH subset specific cytokines dictate DC function and the expression of DC subset specific surface molecules. Moreover, the phenotypes of T cell induced DC subsets are maintained following subsequent stimulation with a panel of toll-like receptor (TLR) agonists, suggesting that TH-derived signals outweigh downstream TLR signals in their influence on DC function. Our preliminary studies indicate that regulatory T cells promote the formation of tolerogenic DCs that are typically associated with tumor progression and poor patient prognosis. The data indicate that intra-tumoral Tregs frequently interact with monocytes within tumor tissue and instruct monocytes to differentiate into IL-10-producing tolerogenic DCs. Such Treg-induced DCs (DCTreg) are subsequently able to instruct naïve T cells to differentiate into FoxP3+, IL-10-producing regulatory T cells with potent suppressive activity. The capacity of Tregs to elicit DCTreg formation represents a physiologic mechanism that on one hand amplifies and perpetuates immune tolerance, but also contributes to attenuated anti-tumor immune responses. We also explored mechanisms capable of depleting inflammatory DCs. While previous studies have indicated that inflammatory DC depletion through systemic elimination of their monocyte precursors with clodronate-loaded liposomes ameliorates pathogenesis in psoriasis and other diseases, translation of these strategies into the clinic is difficult due the importance of monocytes in the clearance of infection. We describe three strategies that avoid the monocyte intermediates in order to directly prevent inflammatory DC formation or deplete inflammatory DCs through antibody-loaded toxins. These strategies provide useful tools for the targeted reduction of inflammatory DCs during disease pathogenesis. In summary, memory T cells dictate the nature of the immune response through the induction of functionally specialized inflammatory DCs. The system we utilized for generating DC subsets with differential TH polarizing capacity has facilitated the elucidation of cell surface and soluble factors governing the biology of TH-promoting DC subsets. These and additional molecules expressed by DC subsets should prove useful for detecting and quantifying each subset in situ and may enable the design of novel therapeutic strategies for T[not]H-associated inflammatory diseases.
  • 2005 Springer
    Kyewski, B.; Suri-Payer, E.
    Also available: Print – yyyy
  • 2014 ScienceDirect
    Wieser, Herbert; Koehler, Peter; Konitzer, Katharina.
    Celiac disease : a complex disorder -- Gluten : the precipitating factor -- Treatment of Celiac disease -- Gluten-free products.
  • 2015 Springer Protocols
    Ryan, Anthony W.
    Celiac disease : background and historical context / Graham D. Turner, Margaret R. Dunne, and Anthony W. Ryan -- Celiac disease : diagnosis / Greg Byrne and Conleth F. Feighery -- Generating transgenic mouse models for studying celiac disease / Josephine M. Ju, Eric V. Marietta, and Joseph A. Murray -- Study designs for exploring the non-HLA genetics in celiac disease / Åsa Torinsson Naluai -- Twenty-four hour ex vivo culture of celiac duodenal biopsies / Sarah E. J. Cooper, Sharon Wilson, and Conleth F. Feighery -- Isolation and cloning of gluten-specific T cells in celiac disease / Yvonne Kooy-Winkelaar and Frits Koning -- Flow cytometric analysis of human small intestinal lymphoid cells / Margaret R. Dunne -- Adaptation of a cell-based high content screening system for the in-depth analysis of celiac biopsy tissue / Sarah E. J. Cooper ... [et al.] -- HLA genotyping : methods for the identification of the HLA-DQ2,-DQ8 heterodimers implicated in celiac disease (CD) susceptibility / Maria Edvige Fasano, Ennia Dametto, and Sandra D'Alfonso -- Detecting allelic expression imbalance at candidate genes using 5' exonuclease genotyping technology / Jillian M. Gahan ... [et al.] -- Gene expression profiling of celiac biopsies and peripheral blood monocytes using taqman assays / Martina Galatola, Renata Auricchio, and Luigi Greco -- Cloning gene variants and reporter assays / Ben Molloy and Ross McManus -- Epigenetic methodologies for the study of celiac disease / Antoinette S. Perry, Anne-Marie Baird, and Steven G. Gray -- Candidate gene knockdown in celiac disease / Ben Molloy ... [et al.] -- Perl one-liners : bridging the gap between large data sets and analysis tools / Karsten Hokamp -- Bioinformatic analysis of antigenic proteins in celiac disease / Cathal P. O'Brien -- Quality control procedures for high-throughput genetic association studies / Ciara Coleman, Emma M. Quinn, and Ross McManus -- Quality control and analysis of NGS RNA sequencing data / Emma M. Quinn and Ross McManus.
  • 2006 Springer
    Gundelfinger, Eckart D.; Schraven, Burkhart; Seidenbecher, Constanze I.
    Also available: Print – 2006
  • 2015 ClinicalKey
    Abbas, Abul K.; Lichtman, Andrew H.; Pillai, Shiv.
    Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelial interaction, and more.
  • 2008 Springer
    Lane, T. E.
  • 2010 Springer
    Ordentlich, Arie; Schafferman, Avigdor; Velan, Baruch.
    The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics / Arthur M. Friedlander -- Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases / Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld and Izhak Inbar, et al. -- Dynamics of Bacillus anthracis Infection and Control Mechanisms / Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui and Michèle Mock -- Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages / James B. Bliska -- The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence / Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim and Gideon Halperin, et al. -- The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence / Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy and Ayelet Zauberman, et al. -- Dissection of the Functions of the IglC Protein of Francisella tularensis / Jeanette E. Bröms, Moa Lavander and Anders Sjöstedt -- Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions / Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner and Rima Z. Shaikhutdinova, et al. -- The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization / Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen and Ayelet Zauberman, et al. -- Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process / Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre and Elisabeth Carniel -- Poxvirus Entry into Host Cells / Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte and P.S. Satheskumar -- Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host / Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely and Sharon Melamed, et al. -- Inhibitors of Innate Immunity from Vaccinia Virus / Geoffrey L. Smith -- Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts / Svetlana Bardenstein and Menachem Banai -- MMP-9 as a Marker for Vaccinia Virus Related Encephalitis / Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi and Udy Olshevsky, et al. -- Epidemic Cowpox Virus Infections in Germany / Andreas Kurth and Andreas Nitsche -- The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection / Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar and David Gur, et al. -- Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) / Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein and Einat Ben-Arie, et al. -- Subtyping Biothreat Bacterial Pathogens / Paul Keim and Talima Pearson -- A Rapid Method for Bacillus anthracis Genotyping / Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss and Anat Zvi, et al. -- Tularemia - A Disease with an Uncertain Impact on Public Health / Roland Grunow, Daniela Jacob, Andrea Kühn and Herbert Nattermann -- Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections / Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen and Avigdor Shafferman -- Novel Live Vaccine Candidates Against Airborne Francisella tularensis / Wayne Conlan and Anders Sjöstedt -- Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) / Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson and Orit Gat, et al. -- Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates / Anat Zvi, Naomi Ariel and Avigdor Shafferman -- Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacity / Michael H. Lehmann, Melanie Kremer, Yasemin Suezer and Gerd Sutter -- Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection / Sharon Melamed, Nir Paran, Tomer Israely, Noam Erez and Shaul Reuveny, et al. -- A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity / V.A. Feodorova, L.N. Pan'kina, E.P. Savostina, O.S. Kuznetsov and N.P. Konnov, et al. -- Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies / Yinon Levy, Yehuda Flashner, Ayelet Zauberman, Avital Tidhar and Moshe Aftalion, et al. -- Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect / Ohad Mazor, Einat Ben-Arie, Adva Mechaly, Ronit Rosenfeld and Hadar Marcus, et al. -- The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores / Zeev Altboum, Haim Levy, Shay Weiss, Avi Pass and Nili Rothschild, et al. -- Reverse Vaccinology in Bacillus anthracis / Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru and Haim Grosfeld, et al.
  • 2010 Springer
    Mahmoudi, Massoud.
    pt. 1. Urticaria and angiodema -- pt. 2. Skin manifestation of drug allergy -- pt. 3. Allergic contact dermatitis -- pt. 4. Other allergies affecting skin and mucous membranes -- pt. 5. Immunologic diseases of the skin.
  • 2009 Springer
    Mahmoudi, Massoud.
    Rhinitis -- Chronic rhinosinusitis -- Allergic diseases of the eye -- Urticaria and angioedema -- Allergic contact dermatitis -- Hypersensitivity pneumonitis -- Atopic dermatitis -- Food allergy -- Drug allergy -- Anaphylaxis -- Eosinophilia and eosinophilic disorder -- Occupational asthma -- Asthma conundrums -- Mastocytosis -- Allergic bronchopulmonary aspergillosis -- HIV/AIDS and complications -- Disorders of immune regulation -- Autoimmune diseases -- Immune-mediated rheumatic diseases -- Immunodeficiency.
  • 2013 Springer
    Mahmoudi, Massoud.
  • 2010
    Eimerman, Patrick Ryan; Amieva, M. R.; Boothroyd, John C.; Contag, Christopher H.; Wandless, Thomas.
    Listeria monocytogenes is a facultative intracellular pathogen that causes severe invasive disease in susceptible populations. Using in vivo bioluminescent imaging, it was recently discovered that this bacterium can colonize the murine gallbladder of otherwise asymptomatic mice. This finding was surprising as L. monocytogenes, after invasion of the intestines, was thought to survive only intracellularly in an infected host and in the gallbladder the bacteria lived extracellularly. It was also surprising that a bacterium could grow and replicate in the pure bile environment of the gallbladder lumen as bile is a potent antimicrobial compound. In this study, we characterized how Listeria monocytogenes is able to reach the gallbladder during infection and examined how this pathogen is able to survive in this environment. Using a mouse adapted L. monocytogenes which expresses a modified InlA capable of binding murine E-cadherin we were able to follow the kinetics of gallbladder colonization after oral infection using in vivo bioluminescent imaging. We then utilized surgical manipulation of the mouse host and repeated the oral infection to determine how L. monocytogenes reaches the gallbladder. Once we had determined the mechanism of gallbladder entry, we then utilized whole genome microarrays to characterize the transcriptome of L. monocytogenes during in vivo growth in the gallbladder and in freshly isolated murine bile. Finally, we attempted to determine what nutrients are utilized by L. monocytogenes during growth in bile and looked at the ability of other bacterial species to grow in this environment. Through these experiments we demonstrated regular asymptomatic gallbladder colonization by L. monocytogenes after oral infection and that L. monocytogenes reaches the gallbladder via the hepatic duct only after first causing systemic infection and escaping the liver. We also demonstrated that the lifestyle in the gallbladder is similar to that in the intestine with the exception of the need for bile resistance genes, and finally that it appears as though simple carbon sources may be utilized during bile growth and that bile may not be as toxic to bacteria as has been thought. Our work suggests that gallbladder colonization may not be exclusive to only L. monocyctogenes and Salmonella Typhi since other bacteria can grow, and in some cases better than L. monocyctogenes, in pure bile.
  • 2010
    Zúñiga, Luis Alejandro; Butcher, Eugene C.; Chawla, Ajay; Jones, Patricia; Martinez, Olivia.
    Inflammation is characterized by the influx and activation of leukocytes to sites of tissue damage. Upon recruitment, immune cells become activated and can secrete pro-inflammatory cytokines and chemoattractants that can modulate cellular responses and leukocyte trafficking. However, if inflammation occurs inappropriately, it can lead to unwanted tissue damage to the host or can affect metabolic processes (e.g. glucose metabolism or bone metabolism). Evidence indicates inflammation also occurs in adipose tissue during obesity and that adipose tissue leukocytes secrete cytokines that can contribute to systemic, chronic inflammation. The mechanisms that regulate inflammation and mediate its effects on metabolism are not fully understood. To help clarify what factors mediate inflammation, we sought to determine the role that the chemerin receptor, CMKLR1, may play in mediating immune cell trafficking to inflamed tissue. We found CMKLR1 is expressed by murine peritoneal macrophages, which can migrate to chemerin in vitro. CMKLR1 was upregulated by TGF[Beta] and downregulated by pro-inflammatory cytokines and TLR ligands. Furthermore, we found that CMKLR1 exacerbated the progression of experimental murine autoimmune encephalomyelitis (EAE). Chemerin was expressed in inflamed central nervous system (CNS) tissue, and microglial cells and CNS-associated myeloid dendritic cells expressed CMKLR1 in mice with EAE. Additionally, we discovered CCRL2 as a novel receptor for chemerin and determined it is a non-signaling decoy receptor which may bind and present chemerin to CMKLR1. We found that CCRL2 is expressed by mouse mast cells and can enhance tissue swelling and tissue leukocyte infiltration during mast cell-dependent passive cutaneous anaphylaxis. In an attempt to uncover a role for chemerin/CMKLR1 in obesity development or obesity-related inflammation, we discovered an unexpected role for the pro-inflammatory cytokine, IL-17, in adipocyte metabolism. IL-17 was upregulated in obese adipose tissue by T cells. IL-17 KO mice were more susceptible to diet-induced obesity. IL-17 inhibited adipocyte development and insulin stimulated glucose uptake by adipocytes. Furthermore, young IL-17 deficient mice were more insulin sensitive than their WT counterparts. Overall, our data indicate a role for chemerin and chemerin receptors in leukocyte migration and function in inflammatory diseases, and suggest that IL-17 regulates metabolic responses associated with obesity.
  • 2010 Springer
    Bruserud, Øystein.
    Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.
    Also available: Print – 2010
  • 2006 Springer
    Lane, T. E.
    Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system / T.E. Lane, J.L. Hardison, and K.B. Walsh -- Cytokine and chemokine networks : pathways to antiviral defense / T.P. Salazar-Mather and K.L. Hokeness -- Herpes simplex virus and the chemokines that mediate the inflammation / D.J.J. Carr and L. Tomanek -- Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections / K.E. Peterson and B. Chesebro -- HIV-1 coreceptors and their inhibitors / N. Ray and R.W. Doms -- A viral conspiracy : hijacking the chemokine system through virally encoded pirated chemokine receptors / H.F. Vischer, C. Vink, and M.J. Smit.
    Also available: Print – 2006
  • 2013
    "The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies reviews scientific findings and stakeholders concerns related to the safety of the recommended childhood immunization schedule. This report also identifies potential research approaches, methodologies and study designs that could inform this question, considering strengths, weaknesses as well as ethical and financial feasibility of each approach. This report draws on data from existing surveillance systems, such as the Vaccine Safety Datalink, could be used and offers the best means for ongoing research efforts regarding the safety of the schedule. In recognition of this, future federal research approaches should: collect and assess evidence regarding public confidence in and concerns about the entire childhood immunization schedule, with the goal to improve communication with health care professionals, and between health care professionals and the public regarding safety; standardize definitions of key elements of the schedule, and relevant health outcomes; establish research priorities on the basis of epidemiological evidence, biological plausibility, and feasibility; and continue to fund and support the Vaccine Safety Datalink project to study the safety of the recommended immunization schedule"--Publisher's description.
  • 2013 CRCnetBASE
    Bagchi, Debasis; Raychaudhuri, Siba P.; Roy, Sashwati.
    Section I. Systems Biology of Inflammation and Regulatory Mechanisms -- Chapter 1. At the Interface between Acute and Chronic Inflammation / Yoram Vodovotz -- Chapter 2. The Cellular Component of Chronic Inflammation / Julie M. Roda, Tim D. Eubank -- Chapter 3. Mast Cells in Chronic Inflammation / Traci A. Wilgus, Brian C. Wulff -- Chapter 4. Hypoxia and Hypoxia-Inducible Factor in Inflammation / Kiichi Hirota -- Chapter 5. Bioactive Phospholipid Mediators of Inflammation / Sainath R. Kotha, Jordan D. Secor, Smitha Malireddy, Gowrishankar Gnanasekaran, Narasimham L. Parinandi -- Chapter 6. Hematopoietic Stem Cells in Atherosclerotic Development and Resolution / Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das -- Chapter 7. Inflammation as a Confounding Factor in Regenerative Medicine / Myron Allukian, Kenneth W. Liechty -- Chapter 8. NOX in the CNS / Annadora J. Bruce-Keller -- Chapter 9. Resolution of Inflammation / Amitava Das, Sashwati Roy -- Chapter 10. H2S in Inflammation / Hyun-Ock Pae, Hun-Taeg Chung -- Section II. Pathologies Associated with Inflammation -- Chapter 11. Is There a Connection between Inflammation and Oxidative Stress? / Chandrakala Aluganti Narasimhulu, Xueting Jiang, Zhaohui Yang, Krithika Selvarajan, Sampath Parthasarathy -- Chapter 12. Chronic Inflammation and Cancer / Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad, Bharat B. Aggarwal -- Chapter 13. Chronic Wounds and Inflammation / Jaideep Banerjee, Chandan K. Sen -- Chapter 14. Multiphasic Roles for TGF-Beta in Scarring / Praveen R. Arany, George X. Huang, Woo Seob Kim -- Chapter 15. Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress / Cameron Rink, Savita Khanna -- Chapter 16. Inflammatory Cascades in Autoimmune Disease / Amita Aggarwal, Arpita Myles -- Chapter 17. Shear Stress and Vascular Inflammation / John Noel, Shampa Chatterjee -- Chapter 18. NGF and Its Receptor System in Inflammatory Diseases / Anupam Mitra, Smriti K. Raychaudhuri, Siba P. Raychaudhuri -- Section III. Nutrition & Therapeutics for Inflammatory Diseases -- Chapter 19. Inflammation, Oxidative Stress, and Antioxidants / Naveen Kaushal, Vivek Narayan, Ujjawal H. Gandhi, Shakira M. Nelson, Anil Kumar Kotha, K. Sandeep Prabhu --Chapter 20. Lipid Biomarkers of Inflammation / Ginger L. Milne -- Chapter 21. Physical Activity and Inflammation / Edite Teixeira de Lemos, Flávio Reis -- Chapter 22. Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes / Philip C. Calder -- Chapter 23. Anti-Inflammatory Phytochemicals, Obesity, and Diabetes / Srujana Rayalam, MaryAnne Della-Fera, Clifton A. Baile -- Chapter 24. Anti-Inflammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome / George Q. Li, Ka H. Wong, Antony Kam, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski, Kelvin Chan -- Chapter 25. Epigenetics and Nutriepigenomics in Chronic Inflammatory Lung Diseases / Saravanan Rajendrasozhan, Isaac K. Sundar, Irfan Rahman -- Chapter 26. Biologics / Ananya Datta Mitra, Debasis Bagchi, Siba P. Raychaudhuri, Smriti K. Raychaudhuri -- Chapter 27. Disease Modifying Anti-Rheumatic Drugs / Nigil Haroon, Vinod Chandran -- Chapter 28. Nonsteroidal Anti-Inflammatory Drugs / Alakendu Ghosh, Pradyot Sinhamahapatra.
  • 2011 Springer
    Mirmirani, Paradi; Price, Vera H.
    Introduction -- Clinical Assessment of the Patient -- Dermatopathology -- Medical Management -- Mechanisms and Current Research -- Predominantly Lymphocytic Group -- Predominantly Neutrophilic Group -- Mixed Group -- End Stage Nonspecific Group -- Personal Experiences of Six Patients.
  • 2009 Springer
    Volcheck, Gerald W.
  • 2008 Springer
    Gaspari, Anthony A.; Tyring, Stephen K.
  • 2009 Springer
    Falus, András.
  • 2015 Springer
    Murrell, Dédée F.
    This clinical case book serves as a useful guide for dermatologists, internists, family practitioners, pediatricians, and anyone else charged with the care of the skin. The case-based format distinguishes this work from a reference-style textbook, instead allowing readers to relate the presented cases to their own patients. Clinical Cases in Autoimmune Blistering Diseases provides help and insight for clinicians in managing this group of serious and debilitating skin conditions, with each case serving as a springboard for further pursuit and more extensive training. It will enable those new to the field to begin to develop a literacy and competence in autoimmune blistering diseases, while experienced dermatologists will find new ways to sharpen their diagnostic and treatment skills.
  • 2012 Springer
    Aghamohammadi, Asghar; Rezaei, Nima.
    Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs.This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.
  • 2014 ScienceDirect
    Dasgupta, Amitava; Wahed, Amer.
  • 2013 ClinicalKey
    Fleisher, Thomas A.; Frew, A. J.; Rich, Robert R.; Schroeder, Harry W.; Shearer, William T.; Weyand, Cornelia M.
    The human immune response -- Organization of the immune system -- Innate immunity -- Antigen receptor genes, gene products, and co-receptors -- The major histocompatibility complex -- Antigens and antigen presentation -- B-cell development and differentiation -- T-cell development -- Cytokines and cytokine receptors -- Chemokines and chemokine receptors -- Lymphocyte adhesion and trafficking -- T-cell activation and tolerance -- Programmed cell death in lymphocytes and associated disorders -- Immunoglobulin function -- Regulatory T cells -- Helper T-cell subsets and control of the inflammatory response -- Cytotoxic T lymphocytes and natural killer cells -- Host defenses in the skin -- Host defenses at mucosal surfaces -- Complement in host deficiencies and diseases -- Phagocyte deficiencies -- Mast cells, basophils, and mastocytosis -- Eosinophils and eosinophilia -- Host defenses to extracellular bacteria -- Host defenses to intracellular bacteria -- Host defenses to spirochetes -- Host defenses to viruses -- Host defenses to protozoa -- Host defenses to helminths -- Approach to the evaluation of the immunodeficient patient -- Infections in the immunocompromised host -- Maturing of the fetal and neonatal immune system -- Aging and the immune system -- Primary antibody deficiencies -- Primary T-cell immunodeficiencies -- Inherited disorders of IFN-y-, IFN-a/€//\-, and NF-kB-mediated immunity -- HIV infection and acquired immunodeficiency syndrome -- External factors inducing immune deficiency -- Immunological mechanisms of airway diseases and pathways to therapy -- Urticaria, angioedema, and anaphylaxis -- Allergic reactions to stinging and biting insects -- Atopic and contact dermatitis -- Food allergy -- Eosinophil-associated gastrointestinal disorders -- Allergic disorders of the eye -- Drug hypersensitivity -- Occupational asthma -- Mechanisms of autoimmunity -- Interface of autoimmunity and immunodeficiency -- Systemic lupus erthematosus -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Sjögren's syndrome -- Scleroderma-systemic sclerosis -- Inflammatory muscle diseases -- Spondyloarthritis -- Small and medium vessel primary vasculitis -- Large-vessel vasculitides -- Systemic autoinflammatory syndromes -- Antiphospholipid syndrome -- Immunohematologic disorders -- Bullous diseases of the skin and mucous membranes -- Immunology of psoriasis -- Myasthenia gravis -- Multiple sclerosis -- Autoimmune peripheral neuropathies -- Immunologic renal diseases -- Inflammation and atherothrombosis -- Autoimmune thyroid diseases -- Diabetes and related autoimmune diseases -- Immunologic lung diseases -- Sarcoidosis -- Immunologic ocular disease -- Immunologic diseases of the gastrointestinal tract -- Inflammatory hepatobiliary diseases -- Principles of tumor immunology -- Tumor immunotherapy -- Lymphoid leukemias -- Lymphomas -- Monoclonal gammopathies -- Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance -- Stem cell transplantation and immune reconstitution in immunodeficiency -- Hematopoietic stem cell transplantation for malignant diseases -- Thymic reconstitution -- Immunoglobulin therapy: replacement and immunomodulation -- Gene therapy -- Glucocorticoids -- Immunomodulating pharmaceuticals -- Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders -- Vaccines -- Immunotherapy of allergic disease -- Biologic modifiers of inflammatory diseases -- Assessment of proteins of the immune system -- Flow cytometry -- Assessment of functional immune responses -- Assessment of neutrophil function -- Assessment of human allergic diseases -- Molecular methods.
    Also available: Print – 2013
  • 2012 Springer
    Hughes, Graham R. V.; Sangle, Shirish.
    pt. 1. The growth of lupus -- 1. Lupus: An introduction -- 2. What is lupus? -- pt. 2. Lupus organ by organ -- 3. Skin --4. Tendons and joints -- 5. Kidney -- 6. The brain -- 7. Heart and blood vessels -- 8. Liver and gastrointestinal tract -- 9. Blood -- pt. 3. Diagnosis and treatment -- 10. Diagnosing lupus -- 11. Treatment -- pt. 4. Lupus-like disorders -- 12. Sjögren's syndrome -- 13. Hughes syndrome (the antiphospholipid syndrome) -- 14. Mixed connective tissue disease (and overlap syndromes) -- 15. Vasculitis -- pt. 5. Lupus-related topics -- 16. Lupus-related topics.
  • 2007 Springer
    Ganjei-Azar, Parvin; Nadji, Mehrdad.
  • 2010 Springer
    Ahmad, Iqbal.
    "Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
  • 2011
    Hoy, Yana Emmy Evangeline; Monack, Denise M.; Relman, David A.; Schneider, David; Sonnenburg, Justin; Spormann, Alfred M.; Theriot, Julie A.
    The importance of the intestinal microbiota to the health of an organism is well recognized. Alterations in the composition of the microbiota are associated with a number of diseases. However, the extent to which the microbiota varies across healthy individuals and time and the causes of this variation are still not fully understood. In order to distinguish between microbial community states of health and disease, the range of healthy microbial communities must be determined. In addition, the effect of perturbations on the microbiota is an area of active research. Recent studies indicate that intestinal infections can have a significant impact on the composition of intestinal microbiota. However, the extent and duration of these changes during different infections have not been fully characterized. My aims were to characterize the range of healthy microbiota in an inbred mouse population over time and to determine the dynamics of alterations in the microbiota during disease. I also wanted to determine if certain characteristics of the microbiota make animals more or less susceptible to infection. In this work, 46 individual healthy mice were sampled over time to assess the range of microbial communities in health. A mouse model of Salmonella enterica serovar Typhimurium infection was used to assess the impact of infection on the microbiota. Mice were sampled prior to infection and over the course of infection. This work finds that the microbiota of healthy mice varies significantly over time and among individuals. However, there are stable differences among individual mice, which may be established at the point of weaning when adult microbial communities develop. In addition, this work finds significant changes in the microbiota during infection that differ with the level of infection. This data also shows that there are some taxa whose abundance prior to infection correlates with outcome of infection. This work provides insights into the dynamics of the microbiota in health and disease and its impact on the health of the host.
  • 2006 Springer
    Zipfel, Peter F.
    Also available: Print – 2006
  • 2014 Springer Protocols
    Gadjeva, Mihaela.
    Overview / Mihaela Gadjeva -- Evaluation of complement function by ELISA / Anja Roos and Jörgen Wieslander -- Classical complement pathway component C1q : purification of human C1q, isolation of C1q collagen-like and globular head fragments and production of recombinant C1q-derivatives. Functional characterization / Mihaela Kojouharova -- Classical complement pathway components C1r and C1s : purification from human serum and in recombinant form and functional characterization / Véronique Rossi ... [et al.] -- Expression and purification methods for the production of recombinant human complement component C2 / Angela W. Norton ... [et al.] -- Purification and characterization of human and mouse complement C3 / Marieta M. Ruseva and Meike Heurich -- Purification of human complement protein C5 / Lars Sottrup-Jensen and Gregers Rom Andersen -- Quantification of complement C5b-9 binding to cells by flow cytometry / Oren Moskovich and Zvi Fishelson -- Challenges and opportunities in fractionation of recombinant human mannan-binding lectin / Thomas Vorup-Jensen -- Genotyping of FCN and MBL2 polymorphisms using pyrosequencing / Lea Munthe-Fog, Hans Ole Madsen, and Peter Garred -- Assay for estimation of the functional activity of the mannan-binding lectin pathway of the complement system / Troels R. Kjaer and Steffen Thiel -- Purification, measurement of concentration, and functional complement assay of human ficolins / Misao Matsushita ... [et al.] -- Purification and functional analysis of human properdin / Joseph O'Flynn ... [et al.] -- Purification and functional characterization of C4b- binding protein (C4BP) / Frida C. Mohlin and Anna M. Blom -- Purification and functional characterization of factor I / Sara C. Nilsson and Anna M. Blom -- C1 inhibitor : quantification and purification / Lilian Varga and József Dobó -- Purification, quantification, and functional analysis of complement factor H / Bing-Bin Yu ... [et al.] -- Factor H-related proteins / Mihály Józsi and Seppo Meri -- Functional evaluation of factor H genetic and acquired abnormalities : application for atypical hemolytic uremic syndrome (aHUS) / Lubka T. Roumenina ... [et al.] -- Anti-factor H autoantibodies assay / Marie-Agnès Dragon-Durey ... [et al.] -- Purification of native surfactant protein SP-A from pooled amniotic fluid and bronchoalveolar lavage / Najmunisa Karbani ... [et al.] -- Purification of surfactant protein D (SP-D) from pooled amniotic fluid and bronchoalveolar lavage / Eswari Dodagatta-Marri ... [et al.] -- Functional analysis of C5a effector responses in vitro and in vivo / Christian M. Karsten, Yves Laumonnier, and Jörg Köhl -- Detection of complement receptors 1 and 2 on mouse splenic B cells using flow cytometry / Luke R. Donius and John H. Weis -- Quantification of complement receptor 2 calcium signaling enhancement using flow cytometry / Luke R. Donius and John H. Weis -- Purification of C1q receptors and functional analysis / Berhane Ghebrehiwet and Ellinor I.B. Peerschke -- Detection of cell membrane-bound CD46 using flow cytometry / Martin Kolev and Claudia Kemper -- Detection of CD59 using flow cytometry / Martin Kolev -- Functional analysis of CD59 using complement-dependent cytotoxicity assay / Martin Kolev -- Detection of soluble CR3 (CD11b/CD18) by time-resolved immunofluorometry / Gitte Krogh Nielsen and Thomas Vorup-Jensen - Analysis of the complement activation in mice / Nirmal K. Banda and Kazue Takahashi -- Opsonophagocytic assay / Markryan Dwyer and Mihaela Gadjeva.
  • 2013 Springer
    Holers, V. Michael; Lambris, J. D.; Ricklin, Daniel.
    Also available: Print – 2013
  • 2013 Springer
    An, Gary; Vodovotz, Yoram.
    An overview of the translational dilemma and the need for translational systems biology of inflammation / Yoram Vodovotz and Gary An -- Part I: Complex systems methods and applications. Translational equation-based modeling / Gilles Clermont ; Agent-based modeling in translational systems biology / Scott Christley and Gary An ; Analysis of heart rate variability / Patrick R. Norris ; Analysis of ventilatory pattern variability / Thomas E. Dick [and seven others] -- Part II. Translational modeling of sepsis and trauma. Disorder of systemic inflammation in sepsis and trauma: a systems perspective / Kent R. Zettel II and Timothy R. Billiar ; Multi-scale equation-based models: insights for inflammation and physiological variability / Jeremy D. Scheff ; Integrating data driven and mechanistic models of the inflammatory response in sepsis and trauma / Nabil Azhar [and five others] ; In silico trials and personalized therapy for sepsis and trauma / Yoram Vodovotz, John Bartels, and Gary An -- Part III: Translational modeling of wound healing. Disorder of localized inflammation in wound healing: a systems perspective / Sashwati Roy, Amitava Das, and Chandan K. Sen ; Equation-based models of wound healing and collective cell migration / Julia Arciero and David Swigon ; Agent-based models of wound healing / Jordan R. Stern [and three others] -- Part IV: Translational modeling of host-pathogen interactions. Modeling host-pathogen interactions in necrotizing enterocolitis / Julia Arciero, Jared Barber, and Moses Kim ; Modeling host-vector-pathogen immuno-inflammatory interactions in malaria / Yoram Vodovotz [and nine others] -- Part V: Future perspectives : translation to implementation. The rationale and implementation of translational systems biology as a new paradigm for the study of inflammation / Gary An and Yoram Vodovotz -- Index.
  • 2006 ScienceDirect
    Alouf, J. E.; Popoff, Michel R.
  • 2013 CRCnetBASE
    Evans, W. Howard; Kwak, Brenda R.; Oviedo-Orta, Ernesto.
    Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
  • 2012 Springer
    Aliberti, Julio.
  • 2012 Springer
    Toman, Rudolf.
    History and Prospects of Coxiella burnetii Research / Karim E. Hechemy -- Phylogenetic Diversity, Virulence and Comparative Genomics / Erin J. van Schaik and James E. Samuel -- Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche / Katja Mertens and James E. Samuel -- Lipopolysaccharide of Coxiella burnetii / Craig T. Narasaki and Rudolf Toman -- Components of Protective Immunity / Guoquan Zhang, Yan Zhang and James E. Samuel -- Proteome of Coxiella burnetii / Robert Ihnatko, Edward Shaw and Rudolf Toman -- Coxiella Subversion of Intracellular Host Signaling / S. Kauser Hussain and Daniel E. Voth -- The Coxiella burnetii Parasitophorous Vacuole / Eric Ghigo, María I. Colombo and Robert A. Heinzen -- Coxiella burnetii Secretion Systems / Justin A. McDonough, Hayley J. Newton and Craig R. Roy -- Role of Lipids in Coxiella burnetii Infection / Stacey D. Gilk -- Axenic Growth of Coxiella burnetii / Anders Omsland -- Developmental Biology of Coxiella burnetii / Michael F. Minnick and Rahul Raghavan -- Genetic Manipulation of Coxiella burnetii / Paul A. Beare -- Role of Innate and Adaptive Immunity in the Control of Q Fever / Christian Capo and Jean-Louis Mege -- Immune Response and Coxiella burnetii Invasion / Amira Ben Amara, Yassina Bechah and Jean-Louis Mege -- Antigenic Analysis for Vaccines and Diagnostics / Laura R. Hendrix and Chen Chen -- Epidemic Q Fever in Humans in the Netherlands / Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever and Mirjam H. A. Hermans, et al. -- Coxiella-like Endosymbionts / Jianmin Zhong -- Molecular Typing of Coxiella burnetii (Q Fever) / Robert F. Massung, Sally J. Cutler and Dimitrios Frangoulidis.
    Also available: Print – 2012
  • 2010
    Goldstein, Matthew J.; Davis, Mark M.; Levy, Ronald; Negrin, Robert S.; Steinman, Lawrence.
    Despite the success of passive immunotherapy with monoclonal antibodies (mAb) directed against tumor cells (e.g. anti-CD20, rituximab), many lymphoma patients eventually relapse. Active immunotherapy for the treatment of lymphoma aims to induce an adaptive and long-lasting antitumor immune response to prevent or prolong time to recurrence. Although antitumor immune cells can be found in cancer patients, these cells may be rendered ineffective in eradicating cancer due to tumor-induced immunosuppression. One approach to overcome this--adoptive cell therapy--involves the isolation of tumor-specific T cells followed by their re-administration to a patient after a myeloablative conditioning regimen. The work discussed in this dissertation describes our studies on a novel approach to adoptive cell therapy for lymphoma. Specifically, we have investigated vaccination methods for generating tumor-reactive T cells in vivo and demonstrate a strategy to isolate this specific population. Prior work from our lab has shown that a combination of chemotherapy (CTX) plus intra-tumor injection of CpG cures a majority of tumors in the A20 mouse B cell lymphoma model. In these studies we found that it was necessary to inject CpG directly into the tumor. We concluded that CpG can have an immunostimulatory effect on either the tumor B cell or on the host APC to enhance uptake and presentation of tumor antigens thereby leading to a cytotoxic CD8 antitumor T cell response. We posited that the effectiveness of the CTX + CpG vaccination maneuver may be limited by endogenous regulatory factors of the immune system. Myeloablation eliminates many of these factors and creates an environment that is conducive to the adoptive transfer of anti-tumor lymphocytes. Transferred cells respond to homeostatic proliferation signals and repopulate 'empty' lymphocyte niches. We utilized CTX + CpG active immunization to generate anti-tumor T cells in vivo and transferred these T cells into lymphodepleted recipient mice. We refer to the preparation of these cells and subsequent transfer as 'immunotransplant'. Transferred T cells cured large and metastatic tumors. We demonstrated that tumor rejection was mediated by donor CD8 T cells. These transferred tumor-specific Teffector cells preferentially expanded, increasing the Teffector:Treg ratio in recipients. This work demonstrates that in situ vaccination is an efficient and effective means to generate T cells for adoptive therapy. The second phase of our work focused on designing an alternative strategy for generating antitumor T cells in vivo. We designed a CpG-loaded tumor cell vaccine made up of irradiated-tumor cells (a rich source of tumor antigens) loaded with CpG. The T cells induced by this vaccine could mediate antitumor immune responses and were more effective when adoptively transferred into lymphodepleted mice. CpG-loaded tumor cells were phagocytosed delivering both tumor antigen and the immunostimulatory CpG molecule to APCs. These APCs then expressed increased levels of costimulatory molecules and induced T cell immunity. TLR9 was required in the APC but not in the CpG-loaded tumor cell. We demonstrate that T cells induced by this vaccine were effective in adoptive cellular therapy for lymphoma and led to regression of large and established tumors. Interestingly, this therapeutic effect could be transferred by CD4 but not by CD8 T cells. This CpG-loaded whole cell vaccination has strong potential for translation to the clinical setting. We were surprised that our CpG-loaded tumor cell vaccine induced an antitumor CD4 T cell response. To date, the field of adoptive cell therapy has focused primarily on CD8 CTLs and our early work with CTX + CpG vaccination supported this paradigm. However, the concept of CD4 T cells coordinating broad, antitumor responses is important for the field of adoptive therapy. CD4 cells play central roles in nearly all aspects of the adaptive immune response including the recruitment of other immune cell types as well as the activation of B cells and APCs. However, clinical translation of using CD4 T cells for adoptive therapy is limited by potential to co-transfer regulatory CD4 T cells (Tregs). In the third phase of our work, we identified a method for isolating viable antitumor CD4 T cells while excluding Tregs based on two surface markers--CD44 and CD137. Adoptive transfer of CD137negCD44hi CD4 T cells, but not other sub-populations, provided protection from B cell lymphoma. We demonstrate that the population of CD137posCD44hi CD4 T cells consists primarily of activated Tregs. In vitro, these CD137pos cells suppressed the proliferation of effector cells in a contact-dependent manner. Moreover, in vivo the addition of CD137posCD44hi CD4 cells to CD137negCD44hi CD4 cells suppressed the antitumor immune response. These results suggest that CD137 expression on CD4 T cells defines a population of activated Tregs that prevent antitumor immune responses. Similar to observations in the murine model, human lymphoma biopsies also contain a population of CD137pos CD4 T cells that are predominantly CD25posFoxP3pos Tregs. In conclusion, our findings identify two surface markers that can be used to facilitate the enrichment of anti-tumor CD4 T cells while depleting an inhibitory Treg population. Together, these findings define a T cell-based therapy for lymphoma. We have established two methods of vaccination that are effective in generating antitumor T cells and show that these cells can reject established and metastatic tumors. T cell responses differ based on the route of vaccination, however we show that both vaccine-induced CD4 and CD8 T cells can mediate tumor rejection. Finally, we have described two surface molecules that could facilitate isolation of tumor-reactive CD4 T cells while removing tumor-reactive regulatory T cells. This work has direct implications for clinical therapy and a proof-of-concept clinical trial of adoptive immunotherapy for mantle cell lymphoma is ongoing.
  • 2007 Springer
    Katsikis, Peter D.; Pulendran, B.; Schoenberger, Stephen P.
    Signal transduction in DC differentiation: winged messengers and Achilles' heel / Inna Lindner ... [et al.] -- Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation / Gabrielle T. Belz ... [et al.] -- Understanding the role of innate immunity in the mechanism of action of the live attenuated yellow fever vaccine 17D / Troy D. Querec and Bali Pulendran -- The function of local lymphoid tissues in pulmonary immune responses / Juan Moyron-Quiroz ... [et al.] -- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity / Jian-Ming Li and Edmund K. Waller -- It's only innate immunity but I like it / Emanuela Marcenaro ... [et al.] -- Innate tumor immune surveillance / Mark J. Smyth, Jeremy Swann, and Yoshihiro Hayakawa -- Regulation of adaptive immunity by cells of the innate immune system: bone marrow natural killer cells inhibit T cell proliferation / Prachi P. Trivedi ... [et al.] -- Induction and maintenance of CD8+ T cells specific for persistent viruses / Ester M.M. van Leeuwen, Ineke J.M. ten Berge, and René A.W. van Lier -- Germinal center-derived B cell memory / Craig P. Chappell and Joshy Jacob -- CD28 and CD27 costimulation of CD8+ T cells: a story of survival / Douglas V. Dolfi and Peter D. Katsikis -- CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses / Santiago Partida Sánchez ... [et al.] -- Vascular leukocytes: a population with angiogenic and immunosuppressive properties highly represented in ovarian cancer / George Coukos ... [et al.] -- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells / Alexandre Corthay -- Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi / Teresa Zelante ... [et al.].
    Also available: Print – 2007
  • 2009 Springer
    Katsikis, Peter D.; Pulendran, B.; Schoenberger, Stephen P.
    Protective effects of type1 interferon in models of intestinal inflammation / Jongdae Lee ... [et al.] -- NK/DC complot / Emanuela Marcenaro ... [et al.] -- Detection of microbes by natural killer T cells / Yuki Kinjo, Mitchell Kronenberg -- Ontogeny of the secondary antibody response, origins and clonal diversity / Craig P. Chappell, Joseph Dauner, Joshy Jacob -- Role of PI3K signalling in the B cell response to antigen / Daniel J. Hodson, Martin Turner -- CD28, old dog, new tricks / Jayakumar R. Nair, Cheryl Rozanski, Kelvin P. Lee -- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection / Thomas Wirth, John T. Harty -- Effects of cancer immunotherapy regimens on primary vs. secondary immune responses and the potential impact on long-term antitumor responses / Kory L. Alderson, William J. Murphy -- New insights into classical costimulation of CD8+ T cell responses / Christine M. Bucks, Peter D. Katsikis -- Peripheral tolerance induction by lymph node stroma / Erika D. Reynoso, Je-Wook Lee, Shannon J. Turley.
    Also available: Print – 2009
  • 2011 Springer
    Katsikis, Peter D.; Pulendran, B.; Schoenberger, Stephen P.
    Is transcription the dominant force during dynamic changes in gene expression? -- MicroRNAs: key components of immune regulation -- KIR/HLA: genetic clues for a role of NK cells in the control of HIV -- Natural killer cell licensing during viral infection -- Bridging innate NK cell functions with adaptive immunity -- Control of innate immunity by memory CD4 T cells -- Strategies and implications for prime-boost vaccination to generate memory CD8 T cells -- Blimp1: driving terminal differentiation to a T -- New role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis -- Impact of differential glycosylation on IgG activity -- Murine model of chronic respiratory inflammation -- Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1 -- Influenza vaccines: what do we want and how can we get it?
  • 2013 Springer
    Katsikis, Peter D.; Pulendran, B.; Schoenberger, Stephen P.
    Also available: Print – 2013
  • 2015 Springer
    Katsikis, Peter D.; Pulendran, B.; Schoenberger, Stephen P.
    1. Type III interferons (IFNs): emerging master regulators of immunity -- 2. Stability of regulatory T cells undermined or endorsed by different type-1 cytokines -- 3. The role of Il-12 and type I interferon in governing the magnitude of CD8 T cell responses -- 4. Functional diversity of human dendritic cells -- 5. Selective dependence of kidney dendritic cells on CX₃CR1, implications for glomerulonephritis therapy -- 6. Mechanisms of memory T cell activation and effective immunity -- 7. Molecular programming of immunological memory in natural killer cells -- 8. Induction of immune tolerance to dietary antigens -- 9. The role of p110ð in the development and activation of B lymphocytes -- 10. Immune memory and exhaustion: clinically relevant lessons from the LCMV model -- Index.
    Also available: Print – 2015
  • 2011 Future Med
    Cicardi, Mario.
    Hereditary angioedema in 2011 / Marco Cicardi -- Hereditary angioedema : diagnosis and pathogenic mechanisms / Allen P. Kaplan -- Current options for the acute treatment and prophylaxis of hereditary angioedema / Laraib Tabba & Timothy J. Craig -- Novel C1 inhibitors for hereditary angioedema / Henriette Farkas & Lilian Varga -- New drug targets and future direction : ecallantide / Jonathan A. Bernstein -- New drug targets and future direction : icatibant / Konrad Bork -- Index.
  • 2014 Future Med
    Incorvaia, Cristoforo.
    Current approaches to allergic rhinitis / Cristoforo Incorvaia -- Allergic rhinitis : symptoms / Nerin N. Bahceciler & Nilufer Galip -- Allergic rhinitis : causes and pathogenesis / Giovanni Passalacqua -- Diagnostic tests in allergic rhinitis / Cristoforo Incorvaia & Franco Frati -- Nasal steroids in allergic rhinitis / Davide Caimmi, Silvia Caimmi, Roberto Raschetti, Ilaria Brambilla & Gian Luigi Marseglia -- Other treatments / Takeshi Nabe -- Index.
  • 2006 Springer
    Lipsky, Peter E.; Radbruch, A.
    Also available: Print – 2006
  • 1991- Wiley
    Coligan, John E.
    ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.
  • 2006 Springer
    Lambris, J. D.
    1. Cross-disciplinary research stirs new challenges into the study of the structure, function, and systems biology of complement / Dimitrios Mastellos and John D. Lambris -- 2. Liver regeneration: a link to inflammation through complement / Robert A. DeAngelis, Maciej M. Markeiwski, and John D. Lambris -- 3. The Role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow / Ryan Reca ... [et al.] -- 4. Complement system and the eye / Purushottam Jha ... [et al.] -- 5. To regeneration ... with complement / Panagiotis A. Tsonis, John D. Lambris, and Katia Del Rio-Tsonis -- 6. Self, non-self and danger: a complementary view / Jörg Köhl -- 7. gClqR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation / Berhane Ghebrehiwet ... [et al.] -- 8. Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer? / Kristina Nilsson Ekdahl ... [et al.] -- 9. Diversified components of the bony fish complement system: more genes for robuster innate defense? / Miki Nakao ... [et al.] -- 10. C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection / Horea Rus, Cornelia Cudrici, and Florin Niculescu -- 11. The Double-edged flower: roles of complement protein C1q in neurodegenerative diseases / Andrea J. Tenner and Maria I. Fonseca -- 12. The Role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis / Nóra Terényi, József Prechl, and Anna Erdei -- 13. The Complement system: a potential target for stroke therapy / J. Mocco ... [et al.] -- 14. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia / Fletcher B. Taylor, Jr., Eric Hack, and Florea Lupu -- 15. Complement activation during sepsis in humans / Heike Schreiber ... [et al.] -- 16. Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects / Yee-Ling Wu ... [et al.] -- 17. A Minimum CR2 binding domain of C3d enhances immunity following vaccination / Joseph F. Bower and Ted M. Ross -- 18. Structure and function of ficolins / Yuichi Endo, Yu Liu, and Teizo Fujita -- 19. Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM) / Lieve Nuytinck ... [et al.] -- 20. Conformational complexity of complement component C3 / Bert J.C. Janssen and Piet Gros -- 21. Disease-associated sequence variations in factor H: a stuctural biology approach / Andrew P. Herbert ... [et al.] -- 22. Transdermal pharmacology of small molecule cyclic C5a antagonists / Lavinia M. Proctor ... [et al.] -- 23. Inactivation of complement by recombinant human C3 derivatives / Edzard Spillner, Johanna Kölln, and Reinhard Bredehorst -- 24. Complement analysis in clinic and research / Tom E. Mollnes and Michael Kirschfink -- 25. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers / Sarah J. Calano ... [et al.].
    Also available: Print – 2006
  • 2007 Springer
    Lambris, J. D.
    Also available: Print – 2007
  • 2012 Springer
    Hajishengallis, George; Lambris, J. D.
    Pentraxins in Humoral Innate Immunity / Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino and Alberto Mantovani -- Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution / Gerardo R. Vasta -- The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells - An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids / Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin and Ewa Bryndza, et al. -- Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds / Elizabeth A. Grice and Julia A. Segre -- Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity / George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh and John D. Lambris -- A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects / Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo and John Trowsdale, et al. -- Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins / Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris and Brian V. Geisbrecht -- Granzyme B: A New Crossroad of Complement and Apoptosis / Mario Perl, Stephanie Denk, Miriam Kalbitz and Markus Huber-Lang -- Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis / Markus Bosmann and Peter A. Ward -- Complement Involvement in Neovascular Ocular Diseases / Ryoji Yanai, Aristomenis Thanos and Kip M. Connor -- Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis / Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson and Kristina N. Ekdahl -- Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection / Qingguo Ruan and Youhai H. Chen -- Function of Act1 in IL-17 Family Signaling and Autoimmunity / Ling Wu, Jarod Zepp and Xiaoxia Li -- Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood / D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris and T. Espevik, et al. -- Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases / Beatriz Novoa and Antonio Figueras -- Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection / Heidi A. Schreiber and Matyas Sandor -- NK/DC Crosstalk in Anti-viral Response / Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta and Simona Sivori -- Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS / Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee and Matyas Sandor, et al. -- Nutritional Immunity: Homology Modeling of Nramp Metal Import / Mathieu F. M. Cellier.
    Also available: Print – 2012
  • v. 285-, 2005- Springer
  • 2005 Springer
    Kuhn, Annegret; Lehmann, Percy; Ruzicka, Thomas.
    Also available: Print – 2005
  • 2014 Springer Protocols
    Vancurova, Ivana.
    Control of pro-inflammatory cytokine release from human monocytes with the use of an interleukin-10 monoclonal antibody / Hardik Patel and Dennis Davidson -- Cytokine-induced neutrophil chemotaxis assay / Dennis Davidson and Hardik Patel -- In vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction / Ved P. Sharma, Brian T. Beaty, Dianne Cox, John S. Condeelis, and Robert J. Eddy -- Chemotactic responses by macrophages to a directional source of a cytokine delivered by a micropipette / Michael Cammer and Dianne Cox -- Assessment of phagocytic activity of cultured macrophages using fluorescence microscopy and flow cytometry / Lokesh Sharma ... [e tal.] -- Assessment of cytokine-modulated proteasome activity / Christopher J. Kirk, Saul R. Powell, and Edmund J. Miller -- Evaluation of the adverse effect of low concentration of cadmium on interleukin-4 induced class switch recombination in burkett's lymphoma Raji cell line / Vladimir Poltoratsky -- Mix-and-measure assay for determining the activation status of endogenous Cdc42 in cytokine-stimulated macrophage cell lysates / Veronika Miskolci ... [et al] -- Analysis of the cell surface expression of cytokine receptors using the surface protein biotinylation method / Mahmud Arif Pavel -- Detection of CXCR2 cytokine receptor surface expression using immunofluorescence / Clarissa Lam ... [et al.] -- Detecting Tie2, an endothelial growth factor receptor, by using immunohistochemistry in mouse lungs / Prajna P. Guha, Sascha A. David, and Chandra C. Ghosh -- Use of shRNA for stable suppression of chemokine receptor expression and function in human cancer cell lines / Nicole Salazar ... [et al.] -- Intracellular staining and detection of cytokines by fluorescence-activated flow cytometry / Giulia Freer -- Cytokine detection by flow cytometry / Jian-Ge Qiu ... [et al.] -- Analysis of IL-17 production by flow cytometry and ELISPOT assays / Ling Zhao ... [et al] -- Interleukin-1 (IL-1) immunohistochemistry assay in oral squamous cell carcinoma / Takaaki Kamatani -- Immunofluorescence and subsequent confocal microscopy of intracellular TNF in human neutrophils / Janet Rollins and Veronika Miskolci -- Evaluating cytoplasmic and nuclear levels of inflammatory cytokines in cancer cells by western blotting / Himavanth R. Gatla ... [et al.] -- Western analysis of intracellular interleukin-8 in human mononuclear leukocytes / Veronika Miskolci ... [et al.] -- Quantitative analysis of bortezomib-induced IL-8 gene expression in ovarian cancer cells / Bipradeb Singha ... [et al.]
  • 2014 Springer
    Yoshimoto, Takayuki; Yoshimoto, Tomohiro.
    The Interleukin-1 Family / Charles A. Dinarello and Mihai G. Netea -- IL-6 and Inflammatory Diseases / Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura, and Masaaki Murakami -- The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders / Harumichi Ishigame and Susumu Nakae -- IL-18 / Wen Li, Yoshimasa Tanaka, and Haruki Okamura -- Interleukin-21: a Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential / Rosanne Spolski and Warren J. Leonard -- Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells / Xiaoting Wang and Wenjun Ouyang -- IL-23 in Health and Disease / Jonathan P. Sherlock, Luis A. Zuniga, and Daniel J. Cua -- IL-36: An Epithelial Cytokine Important in Psoriasis / John E. Sims, Solenne Vigne, Cem Gabay, and Jennifer E. Towne -- Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure / Jagdeep Nanchahal, Peter Taylor, Richard Williams, and Marc Feldmann -- Interleukin-25: Key Initiator of Type 2 Immune Responses / Hiroshi Nakajima, Tomohiro Tamachi, and Koichi Hirose -- Interleukin-33: Multifunctional Alarmin that Promotes Both Health and Disease / Kazufumi Matsushita and Tomohiro Yoshimoto -- Thymic Stromal Lymphopoietin (TSLP) / Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima, and Hongwei Han -- Interleukin-10: Cytokines in Anti-inflammation and Tolerence / Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova, and Anne O'Garra -- Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties / Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi, and Takayuki Yoshimoto -- Interleukin-35: A Novel Mediator of Peripheral Tolerance / Greg M. Delgoffe and Dario A.A. Vignali.
  • 2007 CRCnetBASE
    Plotnikoff, Nicholas P.
    1. Behavioral Effects of Cytokines: A Psychiatrist's Perspective / Ziad Kronfol -- 2. Worried to Death? Stress, Worry, and Immune Dysregulation in Health and HIV -- 3. Psychological Stress and Its Relationship to Cytokines and Inflammatory Diseases / Rama Murali, Margaret D. Hanson, and Edith Chen -- 4. Role of Cytokines in Depression / Ghanshyam N. Pandey and Yogesh Dwivedi -- 5. Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines / Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo -- 6. Stress, Cytokines, and Peripheral Analgesia / Peter John Cabot -- 7. Alexithymia, Stress, and Immunity / Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet -- 8. Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression / Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy -- 9. Stress, Opioid Peptides, and Immune Reponse / Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim -- 10. Met-Enkephalin in Oxidative Stress / Tihomir Balog, Sandra Soboc̆anec, Vis̆nja S̆verko, Helena Haberstock-Debić, and Tatjana Marotti -- 11. Chronic Stress Induces Death of Lymphocytes / Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi -- 12. Interleukin-10 and the Hypothalamic--Pituitary--Adrenal Axis / Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr. -- 13. Cytokines, Stress, and Depression / Adrian J. Dunn -- 14. Immunoconversion in Acute Phase Response / Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs -- 15. Interferon in Health and Disease / Nachum Dafny, Pamela B. Yang, and Stanley A. Brod -- 16. Neuropeptide Precursor Processing in Immunocytes: Involvement in Neuroimmune Communication / Robert Day and Michel Salzet -- 17.Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? / Paola Sacerdote, Sivia Franchi, and Cataldo Martucci -- 18. Human Retroviruses and the Cytokine Network / Massimo Alfano and Guido Poli -- 19. Psychiatric Toxicity of Interferon: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? -- 20. Role of Genetic Predisposition, Cytokines, and Neuroendocrine Response in Development of Thyroid Autoimmunity / Antonio Martocchia and Paolo Falaschi -- 21. Gender Differences, Stress, and Immunity / Nicholas P. Plotnikoff and Robert E. Faith.
  • 2008 ScienceDirect
    Korneva, E. A.; Phelps, Christopher.
  • 2007 Springer Protocols
    Descotes, Jacques; House, Robert V.
    Introduction to cytokines as targets for immunomodulation / Theresa L. Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Hervé Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James E. Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca J. Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin ... [et al.] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy ... [et al.] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- Flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana G. Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth W. Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael J. Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes.
  • 2014 Springer Protocols
    Ranieri, Elena.
    Negative and positive separation techniques for the isolation of antigen-specific CD8+ T cells from blood and tumor tissue / Margherita Gigante, Sharon Natasha Cox, and Elena Ranieri -- In vitro\ex vivo generation of cytotoxic T lymphocytes / Margherita Gigante and Elena Ranieri -- Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry / Iulia Popescu [and three others] -- Intracellular signaling of CTLs / Sharon Natasha Cox -- Monitoring antigen-specific T cell responses using real-time PCR / Devin B. Lowe, Jennifer L. Taylor, and Walter J. Storkus -- CTL ELISPOT assay / Elena Ranieri, Iulia Popescu, and Margherita Gigante -- Methods of purification of CTL-derived exosomes / Angela Montecalvo, Adriana T. Larregina, and Adrian E. Morelli -- Characterization of CTL by microscopy / Giuseppe Stefano Netti -- Intravital imaging of cytotoxic T lymphocytes / Gaetano Faleo, Per-Olof Berggren, and Antonello Pileggi -- The microarray-based approach for the analysis of the transcriptome / Matteo Accetturo, Paola Pontrelli, and Loreto Gesualdo -- miRNome analysis using real-time PCR / Paola Pontrelli, Matteo Accetturo, and Loreto Gesualdo -- Proteomic approaches by SELDI and MALDI-TOF/MS for CTL analysis / Massimo Papale and Maria Teresa Rocchetti -- Two-dimensional gel electrophoresis approach for CTL phosphoproteome analysis / Maria Teresa Rocchetti, Massimo Papale, and Loreto Gesualdo -- Targeting the JAK/STAT pathway in cytotoxic T lymphocytes (CTL) by next generation sequencing (NGS) / Maddalena Gigante, Sterpeta Diella, and Elena Ranieri -- Experimental model for studying the involvement of regulatory cytotoxic T cells in bone resorption / Giacomina Brunetti [and three others] -- CTL and transplantation : tissue in vivo characterization / Federica Rascio, Chiara Divella, and Giuseppe Grandaliano.
  • 2007 Springer
    Ulvestad, Elling.
  • 2009 Springer
    Adorini, L.; Lombardi, Giovanna; Riffo-Vasquez, Yanira.
  • 2009 Springer
    Salter, Russell David; Shurin, Michael R.
    The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • 2008 Springer
    Onji, M.; Akbar, S. M. F.
  • 2008 Karger
    Nestle, F. O.; Nickoloff, Brian J.
    Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
  • 2006 CRCnetBASE
    Hefle, Sue L.; Koppelman, Stef J.
  • 2012 Springer
    Gabain, Alexander von; Klade, Christoph.
    Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
  • 2014 Springer
    Kiefer, Friedemann; Schulte-Merker, Stefan.
    "For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher's description.
  • 2011 Springer
    Balogh, Péter.
    Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
  • v. 39, 2005. Springer
  • 2014 ClinicalKey
    Dabbs, David J.
    Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • 2007 Springer
    Frosch, Peter J.; Le Coz, C.J; Lepoittevin, J.-P.
    Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
  • 2010 Springer
    Preedy, Victor R.; Watson, Ronald R.; Zibadi, Sherma.
  • 2014 Springer
    Chang, Christopher C.; Gershwin, M. Eric; Incaudo, Gary.
    Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
  • 2011
    Peng, Kaitian; Falkow, Stanley; Lewis, David B.; Monack, Denise M.; Schneider, David.
    Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
  • 2006 Springer Protocols
    Brandsma, Janet L.; Saltzman, W. Mark; Shen, Hong.
    DNA vaccine design / Janet L. Brandsma -- Design of plasmid DNA constructs for vaccines / Donna L. Montgomery and Kristala Jones Prather -- Vaccination with messenger RNA / Stave Pascolo -- A stress protein-facilitated antigen expression system for plasmid DNA vaccines / Petra Riedl ... [et al.] -- In vitro assay of immunostimulatory activities of plasmid vectors / Weiwn Jiang, Charles F. Reich, and David S. Pisetsky -- Delivery of DNA vaccines using electroporation / Shawn Babiuk, Sylvia van Drunen Littel-van den Hurk, and Lorne A. Babiuk -- Needle-free injection of DNA vaccines: a brief overview and methodology / Kanakatte Raviprakash and Kevin R. Porter -- Needle-free delivery of veterinary DNA vaccines / Sylvia van Drunen Littel-van den Hurk, Shawn Babiuk, and Lorne A. Babiuk -- Surface-modified biodegradable microspheres for DNA vaccine delivery / Mark E. Keegan and W. Mark Saltzman -- A dendrimer-like DNA-based vector for DNA delivery: a viral and nonviral hybrid approach / Dan Luo ... [et al.] -- Identification of compartments involved in mammalian subcellular trafficking pathways by indirect immunofluorescence / Anne Doody and David Putnam -- Adjuvant properties of CpG oligonucleotides in primates / Daniela Verthelyi -- Complexes of DNA vaccines with cationic, antigenic peptides are potent, polyvalent CD8+ T-cell stimulating immunogens / Petra Riedl, Jörg Reimann, and Reinhold Schirmbeck -- Prime-boost strategies in DNA vaccines / C. Jane Dale ... [et al.] -- Modifying professional antigen-presenting cells to enhance DNA vaccine potency / Chien-Fu Hung, Mu Yang, and T.C. Wu -- Replicase-based DNA vaccines for allergy treatment / Sandra Scheiblhofer ... [et al.] -- Immunological responses of neonates and infants to DNA vaccines / Martha Sedegah and Stepen L. Hoffman -- DNA vaccines for allergy treatment / Richard Weiss, Sandra Sheiblhofer, and Josef Thalhamer -- Protection from autoimmunity by DNA vaccination against T-cell receptor / Thorsten Buch and Ari Waisman -- The use of bone marrow-chimeric mice in elucidating immune mechanisms / Akiko Iwasaki -- A simple method for the production of plasmid DNA in bioreactors / Kristin Listner, Laura Kizer Bentley, and Michel Chartrain -- Practical methods for supercoiled pDNA production / John Ballantyne -- Production of plasmid DNA in industrial quantities according to cGMP guidelines / Joachim Schorr ... [et al.] -- Large-scale, nonchromatographic purification of plasmid DNA / Jason C. Murphy, Michael A. Winters, and Sangeetha L. Sagar -- Assuring the quality, safety, and efficacy of DNA vaccines / James S. Robertson and Elwyn Griffiths.
  • 2014 Springer Protocols
    Fioretti, Daniela; Iurescia, Sandra; Rinaldi, Monica.
    Blueprint for DNA vaccine design / Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of plasmid-mediated transgene expression / Daniela Fioretti, Sandra Iurescia, and Monica Rinaldi -- Strategies for improving DNA vaccine performance/ Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of DNA vaccine efficacy by intracellular targeting strategies / Elisabete Borges Freitas ... [et al.] -- Progresses in DNA-based heterologous prime-boost immunization strategies / Ronald J. Jackson, David B. Boyle, and Charani Ranasinghe -- Development of antibiotic-free selection system for safer DNA vaccination / Jeremy M. Luke, Aaron E. Carnes, and James A. Williams -- Electroporation-based DNA delivery technology : methods for gene electrotransfer to skin / Anita Gothelf and Julie Gehl -- DNA vaccination in skin enhanced by electroporation / Kate E. Broderick, Amir S. Khan, and Niranjan Y. Sardesai -- Intradermal vaccination by DNA tattooing / Joost H. van den Berg ... [et al.] -- Microneedle applications for DNA vaccine delivery to the skin / Hae-yong Seok ... [et al.] -- Multivalent DNA-based vectors for DNA vaccine delivery / Young Hoon Roh ... [et al.] -- Superparamagnetic nanoparticle delivery of DNA vaccine / Fatin Nawwab Al-Deen ... [et al.] -- Plasmid fermentation process for DNA immunization applications / Aaron E. Carnes and James A. Williams -- Pharmaceutical grade large-scale plasmid DNA manufacturing process / Marco Schmeer and Martin Schleef -- Protective and therapeutic DNA vaccination against allergic diseases / Almedina Isakovic ... [et al.] -- Immunotherapy for Alzheimer's disease : DNA- and protein-based epitope vaccines / Hayk Davtyan, Irina Petrushina, and Anahit Ghochikyan -- Tetravalent DNA vaccine product as a vaccine candidate against Dengue / Kevin R. Porter, Nimfa Teneza-Mora, and Kanakatte Raviprakash -- DNA vaccination as a treatment for chronic kidney disease / Yuan Min Wang and Stephen I. Alexander.
  • 2013 Springer
    Baldo, Brian A.; Pham, Nghia H.
    Adverse reactions to drugs and drug allergy: scope of this book --Classification and descriptions of allergic reactions to drugs -- Mechanisms of hypersensitivity -- Diagnosis of allergic reactions to drugs -- β-lacam antibiotics -- Other antimicrobial drugs -- Drugs and other agents used in anesthesia and surgery -- Opiod analgesic drugs -- Nonsteroidal anti-inflammatory drugs -- Contrast media -- Biologics -- Corticosteroids -- Drugs used for chemotherapy -- Proton pump inhibitors -- Postface-concluding remarks.
  • 2014 Springer
    Bosch, Xavier; Khamashta, Munther A.; Ramos-Casals, Manuel.
  • 2009 Springer
    Colloff, Matthew.
    "The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.
  • 2010
    Campbell, J. D.; Davis, Mark M.; Garcia, K. Christopher; Jones, Patricia; McDevitt, Hugh O.
    T cells will usually recognize any pathogen that threatens the body, despite the many different and constantly changing forms these pathogens can take. This is accomplished by the enormous diversity of T-cell receptors that are randomly generated during T-cell maturation. There are a number of distinct mechanisms that drive this diversity: one is the recombination of gene segments, (designated V, D, and J), from pools of many possible gene segments. Another is the addition and deletion of nucleotides at the gene segments joints (between the V, D, and J segments). This yields ~10^15 different possible T-cell receptors, which is many times greater that the number of T cells in the periphery of either mice (~10^8) or humans (~10^11). The T-cell receptor is formed from two polypeptide chains, α and β, each derived from separately rearranged gene segments. Each chain is composed of semi-randomly chosen gene segments. We utilized three transgenes, one limiting the α chain and two limiting the β chain. These progressively limited the number available gene segments of 100 Vα's to 1; 50 Jα's to 2; 30 Vβ's to 1; 2Dβ's to 1 and 13 Jβ's to 2. This reduced the number of gene segment combinations from a theoretical 3,900,000 to 4 combinations. The addition and deletion of nucleotides at the gene segment joints is unaffected. In an in vivo CTL killing assay, the mice with these limited T cell repertoires are able to recognize most but not all of the antigenic peptides tested (9 of 11, in the most restricted mice). Their immunity to Listeria monocytogenes was reduced somewhat; but the LD50 of Yersinia pseudotuberculosis was not diminished by limiting T-cell repertoire, and viral load after murine cytomegalovirus infection was similar to wild type. The limited repertoire mice also exhibited less vigorous alloreactive responses to some haplotypes, indicating that alloreactive responses are influenced by V gene segment compatibility with the MHC. We conclude that N and P nucleotide addition is sufficient for the bulk of T-cell immunity, at least in the laboratory setting. Limiting V(D)J gene segment choice, despite eliminating some T-cell specificities, does not have a dramatic effect on T-cell immunity.
  • 2010
    Mabery, Eric Maurice; Martinez, Olivia M.; Schneider, David; Sonnenburg, Justin; Utz, Paul J.
    Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known concerning where eiger is produced and what genes are regulated by eiger. Here we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. Using tissue specific knockdowns we found that eiger expression in the fat body is required for all of the phenotypes we observed in eiger null mutant flies. This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium. We further characterized the eiger response using transcriptional arrays. We found that the eiger regulates a number of genes involved in metabolism and hormonal signaling during an immune response. How these genes are involved in the immune response is not clear. Finally we examined the role of age related decline of the immune system in D. melanogaster during bacterial infection. We found that vigor and tolerance are reduced when old flies are challenged with a variety of bacterial pathogens.
  • 2015 Springer Protocols
    Hnasko, Robert.
  • 2009 Springer Protocols
    Crowther, J. R.
  • 2012 ClinicalKey
    Actor, Jeffrey K.
    This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • 2012 Future Med
    Reed, Steven G.
    Emulsion-based vaccine adjuvants / Christopher Fox, Darrick Carter & Steven G. Reed -- MF59® : an oil-in-water adjuvant / Jennifer Whitaker, Nadine Rouphael & Mark J. Mulligan -- AS03 adjuvant / Woolf T. Walker & Saul N. Faust -- Innovations in emulsion technology / Christopher B. Fox, Darrick Carter, Susan L. Baldwin, & Steven G. Reed -- Index.
  • 2014 Springer
    Mackay, Ian M.; Rose, Noel R.
  • 2014 Springer
    Mackay, Ian M.; Rose, Noel R.
  • 2005 Springer
    Vohr, Hans-Werner.
  • 2013
    Rhodes, John.
    "At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio"--Provided by publisher.
  • 2008 ScienceDirect
    Jara, Luis J.; Walker, Sara E.
    This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
  • 2015 Springer
    Koch-Nolte, Friedrich.
    Part I. Evolution and detection of endogenous ADP-ribosylation. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system / L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer -- Identification and analysis of ADP-ribosylated proteins / Friedrich Haag and Friedrich Buck -- Part II. ADP-ribosylation by ARTCs (R-S-E ARTs). Photorhabdus luminescens Toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine / Klaus Aktories, Gudula Schmidt and Alexander E. Lang -- Reaction mechanism of mno-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein / Hideaki Tsuge and Toshiharu Tsurumura -- Regulation of nitrogenase by reversible mono-ADP-ribosylation / Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells / Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte and Sahil Adriouch -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish / Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto and Masahiko Watanabe -- Part III. ADP-ribosylation by ARTDs (H-Y-E ARTs). Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family / Ana Filipa Pinto and Herwig Schüler -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 / Max Kaufmann, Karla L.H. Feijs and Bernhard Lüscher -- Regulation of nucleocytoplasmic transport by ADP-tibosylation: the emerging role of Karyopherin-[Beta]1 mono-ADP-ribosylation by ARTD15 / Maria Di Girolamo -- Index.
  • 2010 Springer
    Dauphinee, Shauna M.; Karsan, Aly.
    Also available: Print – 2010
  • 2010 Springer
    Quinn, Peter J.; Wang, Xiaoyuan.
    Endotoxins: Lipopolysaccharides of Gram-negative bacteria / X. Wang and P.J. Quinn -- Purification and characterization of lipopolysaccharides / X. Wang ... [et al.] -- Endotoxins: Relationship between structure, function, and activity / K. Brandenburg, A.B. Schromm and T. Gutsmann -- The diversity of the core oligosaccharide in lipopolysaccharides / A. Silipo and A. Molinaro -- Salmonella-regulated lipopolysaccharide modifications / S.M. Richards, K.L. Strandberg and J.S. Gunn -- The variation of O antigens in Gram-negative bacteria / L. Wang, Q. Wang and P.R. Reeves -- Regulators of TLR4 signaling by endotoxins / A.F. McGettrick and L.A.J. O'Neill -- Membrane partitioning: Is location everything when it comes to endotoxin recognition? / M. Triantafilou and K. Triantafilou -- Endotoxin detection - from limulus amebocyte lysate to recombinant Factor C / J.L. Ding and B. Ho -- The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni / A.P. Moran -- The role of pseudomonas lipopolysaccharide in cystic fibrosis airway infection / S.M. Moskowitz and R.K. Ernst -- Development of small-molecule endotoxin sequestering agents / S.A. David and D. Sil -- Development of an anti-endotoxin vaccine for sepsis / A.S. Cross -- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants / C.B. Fox ... [et al.] -- Targeting endotoxin in the treatment of sepsis / J.-S. Rachoin, C.A. Schorr and R.P. Dellinger -- Lipopolysaccharides in rhizobium-legume symbioses / R.W. Carlson, L.S. Forsberg and E.L. Kannenberg -- Lipopolysaccharides and plant innate immunity / G. Erbs ... [et al.].
  • 2014 Springer Protocols
    Walsh, Garry M.
  • 2013 Springer
    Pascual, Marién; Roa, Sergio.
    Introduction -- Immune System and Atopic Disorders -- Epigenetics -- Epigenetics, Environment, and Allergic Diseases -- Conclusions and Future Perspectives.
  • 2011 Springer
    Ballestar, Esteban.
    An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.
    Also available: Print – 2011
  • 2012 Springer
    Murre, Cornelis.
    Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
  • 2009 Springer Protocols
    Morris, Glenn E.; Reineke, Ulrich; Schutkowski, Mike.
    What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.
  • 2015 Springer
    v. 2 Springer
    Münz, Christian.
  • 11973.
    Roitt, Ivan Maurice.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Rakhra, Kavya; Felsher, Dean; Krams, Sheri M.; Kuo, Calvin Jay; Levy, Ronald.
    Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
  • 2015 Springer
    Allen, Herbert B.
    Atopic dermatitis has been called "the itch that rashes", and this book reveals what causes the "itch". It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. The Etiology of Atopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.
  • 2012
    Cohen, Sheldon G.; Samter, Max.
    Status: Not Checked OutLane Catalog Record
    Antiquity -- 1190 to about 1889 -- 1890 to about 1910 -- 1911 to about 1940 -- 1941 to about 1969 -- 1970 to about 1987.
  • 2015 Springer
    Gattorno, Marco.
    This book, written by very well known opinion leaders in the field, covers all aspects of familial Mediterranean fever, the most common monogenic autoinflammatory disease. The opening chapters explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies. A large part of the book is then devoted to a detailed description of the typical and atypical clinical presentations, the disease course, and potential complications in both pediatric and adult patients. Guidance is provided on the measurement of disease severity and the management of patients in daily practice. The advice regarding treatment is based on the best currently available evidence and attention is also paid to important emerging treatments. The book is part of Springer?s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Monogenic autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Familial Mediterranean fever itself is due to a mutation in the MEFV gene, which codes for the protein pyrin; it is characterized by periodic fever and episodes of painful inflammation in the abdomen, chest, and joints. Familial Mediterranean Fever will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with the disease.
  • 2014 Springer
    Daëron, M.; Nimmerjahn, Falk.
    This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
  • 2014 Springer
    Maibach, Howard I.; Thyssen, Jacob P.
    Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Burks, Wesley; Eigenmann, Philippe A.; James, John M.
    1. Overview of mucosal immunity and development of oral tolerance / Corinne Keet, Robert Wood -- 2. Food antigens / E. N. Clare Mills, Philip E. Johnson, Yuri Alexeev -- 3. Epidemiology of food allergy / Katrina J. Allen, Jennifer J. Koplin -- 4. Clinical overview of adverse reactions to foods / John M. Kelso -- 5. Atopic dermatitis and food allergy / Tamara T. Perry, Debra D. Becton, Stacie M. Jones -- 6. Food-induced urticaria and angioedema / Julia Rodriguez, Jesús F. Crespo -- 7. Pollen-food syndrome / Antonella Muraro, Cristiana Alonzi -- 8. Respiratory tract and food allergy / John M. James -- 9. Food-induced anaphylaxis and food associated exercise-induced anaphylaxis Motohiro Ebisawa -- 10. Eosinophilic gastroenteropathies (eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis) / Dan Atkins, Glenn T. Furuta -- 11. Food protein-induced enterocolitis syndrome, food protein-induced enteropathy, proctocolitis, and infantile colic / Stephanie Ann Leonard, Anna Nowak-Węgrzyn -- 12. Approach to the clinical diagnosis of food allergy / Jonathan O'B. Hourihane -- 13. In vivo and in vitro diagnostic methods in the evaluation of food allergy / S. Allan Bock -- 14. Oral food challenge procedures / Gideon Lack, George Du Toit, Mary Feeney -- 15. Management of food allergy and development of an anaphylaxis treatment plan / Jacqueline Wassenberg, Philippe Eigenmann -- 16. Patient education and empowerment / Kim Mudd, Robert Wood -- 17. Future therapies for food allergies / Anna Nowak-Węgrzyn, Hugh A. Sampson -- 18. Natural history and prevention of food allergy / Scott H. Sicherer, Atsuo Urisu -- 19. Diets and nutrition: cross-reacting food allergens / Vicki McWilliam -- 20. Diagnostic and therapeutic dilemmas: adverse reactions to food additives, pharmacologic food reactions, psychological considerations related to food ingestion / John O. Warner.
  • 2014 CRCnetBASE
    Sicherer, Scott H.
    Chapter 1. Clinical manifestations of food allergy / Jonathan M. Spergel and Hemant P. Sharma -- Chapter 2. Prevalence, triggers, and cross-reactivity / Lynette P. Shek and Katrina (Katie) J. Allen -- Chapter 3. Acute reactions and anaphylaxis / Corinne Keet and Julie Wang -- Chapter 4. Skin conditions associated with food allergy / Tamara T. Perry, A. Wesley Burks, and Stacie M. Jones -- Chapter 5. Gastrointestinal conditions associated with food allergy / Mirna Chehade and Seema Aceves -- Chapter 6. Respiratory conditions associated with food allergy / John M. James -- Chapter 7. Diagnostic testing / Maeve Kelleher, S. Allan Bock, and Jonathan O'B Hourihane -- Chapter 8. The oral food challenge procedure / Sally Noone and Amal H. Assa'ad -- Chapter 9. Dietary management / Marion Groetch -- Chapter 10. Managing food avoidance within the home and outside the home, and lifestyle issues / Jennifer S. Kim, Eyal Shemesh, and Michael C. Young -- Chapter 11. Pharmacologic reactions to food and reactions to food additives / Matthew J. Greenhawt, Timothy J. Franxman, and Ronald A. Simon -- Chapter 12. Prevention / George Du Toit, David M. Fleischer, and Gideon Lack -- Chapter 13. Natural course / Jessica H. Savage and Robert A. Wood -- Chapter 14. Future diagnostics and therapies / Anna Nowak-Wegrzyn and Hugh A. Sampson -- Chapter 15. Practical resources for physicians and patients / Todd A. Mahr and Maria L. Acebal.
  • 2015 Karger
    Ballmer-Weber, Barbara. K.; Ebisawa, Motohiro; Vieths, Stefan; Wood, Robert A.
  • 2011 Springer
    Spanel-Borowski, Katharina.
    The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
  • 2006 Springer
    Ahmed, Rafi; Pulendran, B.
    TLR signaling / S. Akira -- Dendritic cells : translating innate to adaptive immunity / R.M. Steinman and H. Hemmi -- Helper T cell-regulated B cell immunity / L.J. Mcheyzer-Williams, L.P. Malherbe, and M.G. McHeyzer-Williams -- T cell memory / J.T. Tan an C.D. Surh -- The privacy of T cell memory to viruses / R.M. Welsh ... [et al.] -- Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA / M.J. McCluskie and A.M. Krieg.
    Also available: Print – 2006
  • 2013 Ovid
    Paul, William E.
    Section I: Introduction to immunology -- chapter 1. The immune system / William E. Paul -- chapter 2. History of immunology / Steven Greenberg -- Section II: Organization and evolution of the immune system -- chapter 3. Lymphoid tissues and organs / Eitan M. Akirav ... [et al.] -- chapter 4. Evolution of the immune system / Martin F. Flajnik and Louis Du Pasquier -- Section III: Immunoglobulins and B-lymphocytes -- chapter 5. Immunoglobulins: structure and function / Harry W. Schroeder Jr., David Wald, and Neil S. Greenspan -- chapter 6. Immunoglobulins: molecular genetics / Edward E. Max and Sebastian Fugmann -- chapter 7. Antigen-antibody interactions and monoclonal antibodies / Jay A. Berzofsky and Ira J. Berkower -- chapter 8. B-lymphocyte development and biology / Richard R. Hardy -- chapter 9. B-lymphocyte receptors, signaling mechanisms, and activation / Akanksha Chaturvedi ... [et al.] -- chapter 10. B-lymphocyte responses / Michael McHeyzer-Williams -- Section IV: T-lymphocytes -- chapter 11. T-cell antigen receptors / Mark M. Davis and Yueh-Hsiu Chien -- chapter 12. Mechanisms of T-lymphocyte signaling and activation / Takashi Saito -- chapter 13. T-lymphocyte developmental biology / Ellen V. Rothenberg and Ameya Champhekar -- chapter 14. Peripheral T-lymphocyte responses and function / Marc K. Jenkins -- Section V: The intersection of innate and adaptive immunity -- chapter 15. The innate immune system / Luke A. J. O'Neill -- chapter 16. Dendritic cells / Kang Liu, Michel C. Nussenzweig -- chapter 17. Natural killer cells / Wayne M. Yokoyama -- chapter 18. CD1d-restricted natural killer T-cells / Albert Bendelac -- chapter 19. Macrophages and phagocytosis / Siamon Gordon -- chapter 20. Granulocytes and mast cells / Patrizia Scapini ... [et al.] -- chapter 21. The major histocompatibility complex and its proteins / David H. Margulies ... [et al.] -- chapter 22. Antigen processing and presentation / Ted H. Hansen and Paul A. Roche -- Section VI: Induction, regulation, and effector functions of the immune response -- chapter 23. Immunogenicity and antigen structure / Jay A. Berzofsky and Ira J. Berkower -- chapter 24. Rc receptors and their role in immune regulation and inflammation / Jeffrey V. Ravetch and Falk Nimmerjahn -- chapter 25. Type I cytokines and interferons, and their receptors / Warren J. Leonard -- chapter 26. The interleukin-1 family / Charles A. Dinarello and Mihai G. Netea -- chapter 27. Tumor necrosis factor-related cytokines in immunity / Carl F. Ware -- chapter 28. Chemokines / Philip M. Murphy -- chapter 29. Helper T-cell differentiation and plasticity / John J. O'Shea -- chapter 30. Programmed cell death / Andrew L. Snow and Michael J. Lenardo -- chapter 31. Immunologic memory / Shane Crotty, Susan M. Kaech, and Stephen P. Schoenberger -- chapter 32. Immunologic tolerance / Christopher C. Goodnow and Pamela S. Ohashi -- chapter 33. Regulatory/suppressor T-cells / Ethan M. Shevach -- chapter 34. The mucosal immune system / Yasmine Belkaid -- chapter 35. Neurophysiologic reflex mechanisms in immunology / Sangeeta S. Chavan and Kevin J. Tracey -- chapter 36. Complement / B. Paul Morgan -- chapter 37. Cell-mediated cytotoxicity / Judy Lieberman -- Section VII: Immunity to infectious agents -- chapter 38. The immune response to parasites / Thomas A. Wynn ... [et al.] -- chapter 39. Immunity to viruses / Hildegund C. J. Ertl -- chapter 40. Immunity to intracellular bacteria / Anca Dorhoi, Stephen T. Reece, and Stefan H. E. Kaufmann -- chapter 41. Immunity to extracellular bacteria / Moon H. Nahm and Jannet Katz -- chapter 42. Immunology of human immunodeficiency virus infection / Douglas S. Kwon and Bruce D. Walker -- chapter 43. Vaccines / Ennio De Gregorio ... [et al.] -- Section VIII: Immunologic mechanisms in disease -- chapter 44. Autoimmunity and autoimmune diseases / Ken T. Coppieters, Matthias G. von Herrath, and Dirk Homann -- chapter 45. Immunologic mechanisms of allergic disorders / Marsha Wills-Karp and Ian Lewkowich -- chapter 46. Transplantation immunology / Megan Sykes, Kathryn Wood, and David H. Sachs -- chapter 47. Cancer immunology / Hans Schreiber -- chapter 48. Inborn errors of immunity / Jean-Laurent Casanova, Mary Ellen Conley, and Luigi D. Notarangelo.
  • 2008 Ovid
    Paul, William E.
    Also available: Print – 2008
  • 2002 Karger
    Breitenbach, Michael; Crameri, Reto; Lehrer, Samuel B.
    Also available: Print – 2002
  • 2005 Springer
    Fidel, Paul L.; Huffnagle, Gary B.
    Also available: Print – 2005
  • 2001 Karger
    Bergstresser, Paul R.; Takashima, A.
    T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotection
    Also available: Print – 2001
  • 2005 Springer
    Prud'homme, Gérald J.
    Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
    Also available: Print – 2005
  • 2012 Springer
    Scheiblhofer, Sandra; Thalhamer, Josef; Weiss, Richard D.
  • 2012 Springer
    Yamanaka, Ryuya.
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
    Also available: Print – 2012
  • 2014
    Agache, Ioana; Akdis, Cezmi A.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    Axford, John S.
    Also available: Print – 2005
  • 2009 Springer
    Wardle, E. N.
  • 2012 Springer Protocols
    Kalyuzhny, Alexander E.
    Unique strengths of ELISPOT for T cell diagnostics / Paul V. Lehmann and Wenji Zhang -- The impact of harmonization on ELISPOT assay performance / Sylvia Janetzki and Cedrik M. Britten -- Equine ELISPOT assay to study secretion of IFN[gamma] and IL-4 from peripheral blood mononuclear cells / Jodi Hagen [and others] -- Utilization of feline ELISPOT for mapping vaccine epitopes / Jeffrey R. Abbott [and others] -- Analyzing cellular immunity to AAV in a canine model using ELISPOT assay / Zejing Wang [and others] -- Dual- and triple-color fluorospot / Niklas Ahlborg and Bernt Axelsson -- ELISPOT assay as a tool to study oxidative stress in lymphocytes / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay for neuroscience research : studying TNF[alpha] secretion from microglial cells / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay as a tool to study the effects of stem cells on cytokine secretion / Jun-Seop Shin and Chung-Gyu Park -- Combining ELISPOT and ELISA to measure amounts of cytokines secreted by a single cell / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- How ELISPOT morphology reflects on the productivity and kinetics of cells' secretory activity / Alexey Y. Karulin and Paul V. Lehmann -- Mathematical algorithms for automatic search, recognition, and detection of spots in ELISPOT assay / Sergey S. Zadorozhny and Nikolai N. Martynov -- Objective, user-independent ELISPOT data analysis based on scientifically validated principles / Wenji Zhang and Paul V. Lehmann -- Statistical analysis of ELISPOT assays / Marcus Dittrich and Paul V. Lehmann -- Response determination criteria for ELISPOT : toward a standard that can be applied across laboratories / Zoe Moodie [and others] -- Detection of Vaccinia virus-specific IFN[gamma] and IL-10 secretion from human PBMCs and CD8 T cells by ELISPOT / Benjamin J. Umlauf [and others] -- ELISPOT assays to enumerate bovine IFN-[gamma]-secreting cells for the development of novel vaccines against bovine tuberculosis / Martin Vordermeier and Adam O. Whelan -- IL-7 addition increases spot size and number as measured by T-SPOT. TB® / Marsha L. Feske [and others] -- Overview of membranes and membrane plates used in research and diagnostic ELISPOT assays / Alan J. Weiss.
  • 2008 CRCnetBASE
    Donnenberg, Albert David; O'Gorman, Maurice R. G.
    Overview of immunity / James D. Folds -- Statistics of immunological testing / Albert D. Donnenberg -- Human immunoglobulins / Robert G. Hamilton -- The complement system / Patricia C. Giclas -- Cellular immunology : monitoring of immune therapies / Theresa L. Whiteside -- Understanding clinical flow cytometry / Albert D. Donnenberg and Vera S. Donnenberg -- Leukemia and lymphoma immunophenotyping and cytogenetics / Maria A. Proytcheva -- Guidelines for the use of flow cytometry in the management of patients infected with the human immunodeficiency virus type-1 and the acquired immunodeficiency syndrome / Maurice R.G. O'Gorman -- Role of flow cytometry in the diagnosis and monitoring of primary immunodeficiency disease / Maurice R.G. O'Gorman -- Detection and characterization of the T-cell receptor repertoire / Gulbu Uzel -- Human leukocyte differentiation antigens, cluster of differentiation : past, present, and future / Maurice R.G. O'Gorman -- Immunologic diagnosis of autoimmunity / Noel R. Rose -- Autoimmune and immune-mediated diseases of the gastrointestinal tract / Stefano Guandalini, Mala Setty, and Bana Jabri -- Serologic testing for infectious diseases / John L. Schmitz -- Molecular techniques applied to infectious diseases / Jennifer S. Goodrich and Melissa B. Miller -- Cytokines : regulators of immune responses and key therapeutic targets / Barbara Detrick, Chandrasekharam N. Nagineni, and John J. Hooks -- Measuring human cytokines / Holden T. Maecker -- The human major histocompatibility complex and DNA-based typing of human leukocyte antigens for transplantation / Susana G. Marino, Andrés Jaramillo, and Marcelo A. Fernández-Viña -- Relevance of antibody screening and crossmatching in solid organ, hematopoietic stem cell transplantation, and blood transfusion / Chee L. Saw ... [et al.] -- Functional assessment of immunosuppression : monitoring posttransplant alloreactivity with flow cytometric mixed lymphocyte cocultures / Chethan Ashok Kumar ... [et al.].
    Also available: Print – 2008
  • 2015 Springer
    Lin, Fan; Prichard, Jeffrey.
    In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. ℗ℓ Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. ℗ℓ Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
  • 2011 Springer
    Lin, Fan.
    Quality management and regulation / Jeffrey Prichard -- Technique and troubleshooting of antibody testing / Fan Lin and Jianhui Shi -- Overview of automated immunohistochemistry / Jeffrey Prichard, Angela Bitting, and Joe Myers -- Automated staining : Dako perspective / Ole F. Rasmussen and Andreas Schønau -- Automated staining : Ventana perspective / Angela Sattler -- Tissue microarray / Myra Wilkerson and Erin Powell -- Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens / Fan Lin and Haiyan Liu -- Exfoliative cytopathology / Steven Meschter and Jan F. Silverman -- Predictive markers of breast cancer : ER, PR, and HER2 / Jeffrey Prichard, David Hicks, and Elizabeth Hammond -- Central and peripheral nerve system tumors / Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller -- Thyroid and parathyroid gland / Haiyan Liu, Fan Lin, and Ronald A. DeLellis -- Adrenal gland / Hanna G. Kaspar -- Salivary gland and other head and neck structures / Conrad Schuerch -- Lung, pleura, and mediastinum / Kai Zhang and Phillip Cagle -- Breast / Haiyan Liu -- Uterus / Hanna G. Kaspar -- Ovary / Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson -- Prostate gland / Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai -- Urinary bladder / Myra Wilkerson -- Kidney / Fan Lin and Ximing J. Yang -- Testis and paratesticular tissues / Myra Wilkerson -- Pancreas and ampulla / Fan Lin and Hanlin L. Wang -- Liver, bile ducts, and gallbladder / Jeffrey Prichard and Fan Lin -- Upper gastrointestinal tract / Jinhong Li and Fan Lin -- Lower gastrointestinal tract and microsatellite instability / Jinhong Li and Fan Lin -- Soft tissue and bone tumors / Shaobo Zhu and Markku Miettinen -- Lymph node / Xiaohong (Mary) Zhang and Nadine S. Aguilera -- Bone marrow / R. Patrick Dorion and Xiaohong (Mary) Zhang -- Infectious diseases / Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner -- Skin / Tammie Ferringer -- Application of direct immunofluorescence for the skin and mucosal biopsies : a practical review / William B. Tyler -- In situ hybridization in surgical and cytologic specimens / Hong Yin and Barbara Paynton.
  • v. 1-, 2004- ScienceDirect
  • 2009 Springer
    Franceschi, Claudio; Fülöp, Tamas; Hirokawa, Katsuiku; Pawelec, G.
  • 2010
    Tan, Shumin; Amieva, M. R.; Falkow, Stanley; Nelson, W. J.; Theriot, Julie A.
    Helicobacter pylori is a bacterium that chronically infects the stomachs of more than half the human population, in some cases leading to serious diseases such as gastric cancer and ulcers. H. pylori intimately interact with the gastric epithelial surface, but much remains unknown about its life on the cell surface. The bacterium possesses several tools for its close interaction with the gastric epithelia, including a type IV secretion system, through which the virulence factor CagA is directly translocated into host cells. This dissertation focuses on how H. pylori's close interactions with the epithelial cells allows it to modify the apical cell surface to turn it into a replicative niche for the bacterium. Using live-cell microscopy to follow the fate of individual bacteria on the cell surface, we find that H. pylori is able to utilize the apical cell surface as a replicative niche, even in conditions that do not support the growth of free-swimming bacteria. Experiments with a polarized epithelial model system show that the bacterium's major virulence factors CagA and VacA both play important roles in enabling H. pylori growth and microcolony formation on the apical cell surface, by mediating perturbation of host cell polarity and intracellular trafficking processes. We find that iron is one important micronutrient that H. pylori acquires from host cells during colonization of the polarized epithelium. CagA and VacA act in concert to affect the polarized process of transferrin/transferrin receptor recycling and iron uptake in the host cells, resulting in the mis-sorting of a subset of the transferrin/transferrin receptor complex to the colonizing bacteria on the apical cell surface. This process is functionally important for the bacteria, as downregulation of transferrin receptor expression resulted in a decreased ability of H. pylori to colonize the polarized epithelium. These studies establish the cell surface as a replicative niche, which presents challenges that require bacterial adaptation for its successful utilization. Our findings also illustrate the concept that contact-dependent bacterial virulence factors may be used for the perturbation of host cell physiology for the bacterium's benefit, allowing acquisition of needed factors directly from host cells, and colonization of the apical cell surface.
  • 2012 ClinicalKey
    Hsi, Eric D.
    Section 1. Non-neoplastic disorders -- section 2. Lymphomas -- section 3. Leukemias, chronic myeloproliferative neoplasms, and myelodysplasia -- section 4. Disorders of histiocytes, mast cells, plasma cells, spleen, and ancillary techniques.
  • 2012 Springer
    Lee, Benhur; Rota, Paul A.
    Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K. T. Wong and C. T. Tan -- Henipaviruses in Their Natural Animal Hosts / D. J. Middleton and H. M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
  • 2013 Springer
    Bartenschlager, Ralf.
    Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
  • 2008 Springer
    Jirillo, E.
    Innate immunity in type C hepatitis / Tetsuo Takehara and Norio Hayashi -- Mechanisms of interferon action and resistance in chronic hepatitis C virus infection: lessons learned from cell culture studies / Srikanta Dash ... [et al.] -- Immunological parameters influencing adaptive immune responses to the hepatitis C virus / Patrick Bertolino, Geoffrey W. McCaughan, and David G. Bowen -- Immune responses against the hepatitis C virus and the outcome of therapy / Paul Klenerman and Eleanor Barnes -- Other microbial components associated with hepatitis C virus infection: their effects on interferon- a/ribavirin treatment / Luigi Amati, Vittorio Pugliese, and Emilio Jirillo -- Interferon-induced effector proteins and hepatitis C virus replication / Michael Frese and Eva Dazert -- Treatment of chronic hepatitis C with different genotypes / James Fung, Ching-Lung Lai, and Man-Fung Yuen -- Interferon treatment of hepatitis C virus infection: from basic biology to clinical application / Norihiro Furusyo, Masayuki Murata, and Jun Hayashi -- Interferon-based therapy for hepatitis C virus infections / Ming-Lung Yu and Wan-Long Chuang -- Treatment of chronic hepatitis C in "difficult-to-treat" patients in the clinical setting / Ana Moreno, Rafael Bárcena, and Carmen Quereda -- Effects of combined IFN-alpha/ribavirin treatment in HCV disease-related progression / Davide Festi ... [et al.] -- Pegylated interferons: clinical applications in the management of hepatitis C infection / S. James Matthews and Christopher McCoy.
  • 2014 Springer
    Brasier, Allan R.
    Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.
    Also available: Print – 2014
  • 2010 Springer
    Thurmond, Robin L.
    One hundred years of histamine research / Katherine Figueroa and Nigel Shankley -- Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs -- Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu -- Abstract -- Histamine in allergic rhinitis / Thomas Taylor-Clark -- The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.] -- The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate -- Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer -- Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff -- Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy -- Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula -- Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas -- The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond.
    Also available: Print – 2010
  • 2015 Springer
    Jarisch, Reinhart.
    Histamine is an important mediator of allergic diseases such as hay fever and bronchial asthma, food allergies, urticaria, and drug hypersensitivity. Knowledge of histamine as a cause of numerous non-allergic symptoms and signs is, however, limited. In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, atopic dermatitis, and osteoporosis. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages, and intolerance to red wine. Diagnosis of histamine intolerance is explained, and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the conditions mentioned above and also consider the relation of histamine to vitamin B6 and the specific immunotherapy of allergies. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance, and by assisting in the selection of therapeutic measures.
  • 2014 Karger
    Bergmann, Karl-Christian; Ring, Johannes.
  • 2009 ScienceDirect
    Silverstein, Arthur M.
    Also available: Print – 2009
  • 2014 ScienceDirect
    Nagy, Zoltan A.
    A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author.
  • 2011 Springer
    Plotkin, Stanley A.
    "The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases. However, no vaccine development has been easy and there is an interesting story attached to each. The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries. The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine."--Publisher's website.
  • 2009 Springer
    Paul, Robert H.; Sacktor, Ned Charlton; Tashima, Karen Tokie; Valcour, Victor.
    Neurocognitive changes in AIDS: evolution of treatment of HIV infection / Erna Milunka Kojic and Charles C.J. Carpenter -- Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes, and epidemiology of hepatitis C infection among HIV-positive individuals / Karen T. Tashima and Aadia I. Rana -- New insights into HIV neuropathogenesis / Tory P. Johnson and Avindra Nath -- Neuropathological findings associated with long-term HAART / Iain C. Anthony and Jeanne E. Bell -- Biomarkers of HIV-related central nervous system disease / Bruce James Brew and Scott Letendre -- Neuroimaging among HIV-infected patients: current knowledge and future directions / David F. Tate ... [et al.] -- The assessment of HIV-associated neurocognitive disorders: new challenges in the HAART era / Lucette A. Cysique and Bruce J. Brew -- The changing face of HIV-associated cognitive and neuropsychiatric disturbance / Ron Cohen -- Youth with HIV/AIDS: neurobehavioral consequences / Susannah Allison, Pamela L. Wolters, and Pim Brouwers -- Co-occurrence of HIV, hepatitis C, and substance use disorders: effects on brain functioning / Raul Gonzalez, Phillip J. Quartana, and Eileen M. Martin -- The functional impact of HIV-associated neuropsychological decline / Matthew J. Wright ... [et al.] -- Adjunctive therapy for long-term support of cognitive impairment / Joshua T. Dearborn ... [et al.] -- HIV-1 genetic diversity and its biological significance / Michael M. Thomson -- Opportunistic infections in the brain in developing countries / Marcus Tulius T. Silva and Beatriz Grinsztejn -- Impact of Clade diversity on neuropsychological outcomes / Robert Paul ... [et al.] -- The effects of aging on HIV disease / Robert C. Kalayjian and Lena Al-Harthi -- Neuropsychology of healthy aging / Molly E. Zimmerman and Adam M. Brickman -- Interactions between advanced age and HIV cognitive impairment / Victor Valcour and Aaron M. McMurtray.
  • 2014 Springer
    Pantophlet, Ralph.
    Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.-- Source other than Library of Congress.
  • 2010
    Hotson, Andrew Neely; Amieva, M. R.; Jones, Patricia; Nolan, Garry P.; Relman, David A.
    The immune response to a pathogen is a complex interplay between host factors aimed to eradicate the pathogen, and microbe virulence proteins designed to subvert the host. To successfully combat a pathogen, the host must identify the insult and activate an immune response tailored to eliminate the specific microbe. This entails cell signaling at the level of innate immunity to detect the pathogen and mount an immediate non-specific response, while also communicating to bystander cells to shape the scope of the adaptive arm of immunity. The work herein investigates how the intracellular signaling network is activated and perturbed across cell types and hematopoietic tissues during bacterial infection. An introductory background on the current knowledge in the field of immune signaling is provided in chapter 1. Antigen presenting cells detect pathogenic motifs via pattern recognition receptors including toll-like receptors. This triggers an intracellular signaling cascade with specific transcriptional consequences, including the production of cytokines. In turn, these cytokines alert additional cell types to activate specific signal transducer and activator of transcription (STAT) transcription factor family members. Thus, detection of a microbe initiates rapid signaling across leukocytes to set the stage for the immune response. Chapter 2 focuses on cell signaling experiments in a murine model for the onset of sepsis. Mice were acutely challenged with avirulent E. coli and Listeria monocytogenes to study the host response without pathogenic manipulation of host signaling by bacterial virulence factors. Bacterial challenge causes macrophages and dendritic cells to become attenuated in their ability to respond to TLR agonists, a hallmark of endotoxin tolerance. Also, it induces global dampening of the STAT response to cytokines across all cell types; splenocytes from challenged mice poorly respond to cytokine stimulation. Cytokines secreted by antigen presenting cells act on bystander cells and induced negative feedback, including SOCS expression and receptor endocytosis that prevent further STAT activation. Thus, bacterial recognition causes host immune activation followed by subsequent suppression of signaling. The work in chapter 3 transitions to a model of chronic infection with pathogenic Salmonella typhimurium. In addition to examining the innate response, this model enables investigation of adaptive immunity by monitoring the activation of T cells, their cytokine response profile, and TH-biasing by the transcription factors they express and cytokines they produce. During chronic infection, B cells and effector T cells undergo expansion but not contraction over the first 30 days, demonstrating that the immune system establishes a new equilibrium. However, the degree of cell expansion, as well as the ability of these cells to respond to cytokine, is quite variable across mice. These mice also have varied levels of bacterial burden, and the shape of the immune response denotes disease severity. High bacterial load is associated with trademarks of innate immunity such as elevated neutrophil numbers, serum cytokine levels, and the dampened STAT signaling observed during bacterial challenge in chapter 2. In contrast, the mice that control infection are enriched for markers of adaptive T cell immunity: high numbers of TH1 effector T cells, T cell proliferation, ability to respond to cytokines, and fewer regulatory T cells. Therefore, a strong adaptive response is correlated with containing the infection, while an innate response is indicative of high bacterial levels. This thesis concludes in chapter 4, with a discussion of how the findings fit in the context of cell signaling in other disease states. Leukemia and lymphomas, diseases of uncontained cell growth, are characterized by hyperactive cell signaling. In contrast, an activated immune response, such as during auto-immunity or in cancer infiltrating T cells, is marked by repressed ability to respond to cytokines. As inhibited cytokine responses were also observed during bacterial challenge and during severe chronic infection, it appears that a commonality amongst disease that activate an immune response is negative feedback to dampen further signaling and restrict inflammation.
  • 2013 Springer
    Chhatwal, G. Singh.
    Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
  • 2008 Springer
    Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2008
  • 2013 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2013
  • 2009 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Shiga-toxin producing escherichia coli and the hemolytic uremic syndrome / Christina K. Ahn, Nicholas J. Holt, Phillip I. Tarr -- Global epidemiology of pneumococcal disease - new prospects for vaccine control / Vinicius C. Antao, William P. Hausdorff -- Current concepts of the pathogenesis of RSV bronchiolitis / Louis Bont -- How can we eradicate pertussis / James D. Cherry -- Recognition and management of encephalitis in children / James D. Cherry -- Microbiology and management of pleural empyema / Julia Clark -- Pneumococcal conjugate vaccines probe studies / Ron Dagan -- New findings in primary immunodeficiency / Andrew R. Gennery, Andrew J. Cant -- Routine use of influenza vaccine / David Isaacs -- Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for gram positive infections / Sheldon L. Kaplan -- Significance of serotype replacement for pneumococcal disease and antibiotic resistance / Keith P. Klugman -- Childhood intra-thoracic tuberculosis / Ben J. Marais -- Antibiotic pipeline in pediatrics / George H. McCracken -- Paediatric drug development and clinical trials / E. David G. McIntosh -- Influenza in pregnancy / Shelly McNeil, Beth Halperin, Noni MacDonald -- Febrile neutropenia in children with cancer / Stéphane Paulus, Simon Dobson -- PANDAS syndrome / Michael E. Pichichero -- Fever in the returned paediatric traveller / F. Andrew I. Riordan -- Molecular diagnostics of primary immunodeficiencies / Mirjam van der Burg, Menno C. van Zelm, Jacques J.M. van Dongen -- Human genetic resistance to malaria / Thomas N. Williams.
    Also available: Print – 2009
  • 2010 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2010
  • 2011 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    The value of vaccination / David E. Bloom -- Recent trends in global immunisation / Gustav J.V. Nossal -- New advances in typhoid fever vaccination strategies / Zulfiqar A. Bhutta ... [et al.] -- Prevention of vertical transmission of HIV in resource-limited countries / Catherine M. Wilfert ... [et al.] -- Pneumonia in children in developing countries / Frank Shann -- Darwin, microbes and evolution by natural selection / E. Richard Moxon -- Human herpesvirus 6 / Charles G. Prober -- Advances in the diagnosis and management of central venous access device infections in children / Asha Bowen and Jonathan Carapetis -- Moraxella catarrhalis-pathogen or commensal? / Christoph Aebi -- Anaerobic infections in children / Itzhak Brook -- Encephalitis diagnosis and management in the real world / Sarah S. Long -- Toxic shock syndrome-evolution of an emerging disease / James K. Todd -- Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency / Mirjam van der Burg ... [et al.] -- Mumps is back : why is mumps eradication not working? / Noni Macdonald ... [et al.] -- Neonatal herpes simplex virus infections: where are we now? / Clara Thompson and Richard Whitley -- Rational approach to pediatric antifungal therapy / William J. Steinbach -- Antiviral therapy of CMV disease in children / Mike Sharland ... [et al.] -- Infectious hazards from pets and domestic animals / Mona Al-Dabbagh and Simon Dobson -- Novel technology to study co-evolution of humans and Staphylococcus aureus: consequences for interpreting the biology of colonisation and infection / Alex van Belkum -- A practical approach to eosinophilia in a child arriving or returning from the tropics / Penelope Bryant and Nigel Curtis.
    Also available: Print – 2011
  • 2011 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Our Time of Pestilence: Purchasing Immunity and Ignoring the Misery of Others / Philip Alcabes -- Neonatal Meningitis: Can We Do Better? / Paul T. Heath, Ifeanyichukwu O. Okike and Clarissa Oeser -- Approaches Towards Avoiding Lifelong Antiretroviral Therapy in Paediatric HIV Infection / Philip J. R. Goulder and Andrew J. Prendergast -- How Short Is Long Enough for Treatment of Bone and Joint Infection? / Markus Pääkkönen and Heikki Peltola -- What's New in Diagnostic Testing and Treatment Approaches for Mycoplasma pneumoniae Infections in Children? / Ken B. Waites -- Pigs, Poultry, and Pandemic Influenza: How Zoonotic Pathogens Threaten Human Health / Thijs Kuiken, Ron Fouchier, Guus Rimmelzwaan, Judith van den Brand and Debby van Riel, et al. -- Kingella kingae Infections in Children: An Update / Inbal Weiss-Salz and Pablo Yagupsky -- Influenza Pandemics / Ruth Elderfield and Wendy Barclay -- Management of Shunt Related Infections / Mona Al-Dabbagh and Simon Dobson -- Nontuberculous Lymphadenopathy in Children: Using the Evidence to Plan Optimal Management / Julia E. Clark -- Pediatric Brucellosis: An (Almost) Forgotten Disease / Pablo Yagupsky -- Q Fever: Still More Queries than Answers / Corine E. Delsing, Adilia Warris and Chantal P. Bleeker-Rovers -- Rickettsioses in Children: A Clinical Approach / Emmanouil Galanakis and Maria Bitsori -- What is the Evidence Behind Recommendations for Infection Control? / Christina Gagliardo and Lisa Saiman -- What Do We Know About How to Treat Tuberculosis? / Ben J. Marais -- Bacterial Meningitis in Childhood / Manish Sadarangani and Andrew J. Pollard -- Mycobacterium marinum Infection / Marc Tebruegge and Nigel Curtis.
    Also available: Print – 2011
  • 2014 Springer
    Horsnell, William.
    "Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"--Publisher's description.
    Also available: Print – 2014
  • 2008 Springer
    Kitamura, Daisuke.
    Recognition of pathogens: toll-like receptors / Satoshi Uematsu, Shizuo Akira -- Strategies of natural killer (NK) cell recognition and their roles in tumor immunosurveillance / C. Andrew Stewart, Eric Vivier -- Recent progress on paired immunoglobulin-like receptors / Hiromi Kubagawa ... [et al.] -- Self-nonself recognition through B-cell antigen receptor / Daisuke Kitamura -- How do T cells discriminate self from nonself? / Catherine Mazza, Bernard Malissen -- Fc receptors / Falk Nimmerjahn, Jeffrey V. Ravetch -- Self and nonself recognition by coreceptors on B lymphocytes: regulation of B lymphocytes by CD19, CD21, CD22, and CD72 / Kozo Watanabe, Takeshi Tsubata -- Co-receptors in the positive and negative regulation of T-cell immunity / Helga Schneider, Christopher E. Rudd.
  • 2016
    Sompayrac, Lauren.
    1. An overview -- 2. The innate immune system -- 3. B cells and antibodies -- 4. The magic of antigen presentation -- 5. T cell activation -- 6. T cells at work -- 7. Secondary lymphoid organs and lymphocyte trafficking -- 8. Restraining the immune system -- 9. Self tolerance and MHC restriction -- 10. Immunological memory -- 11. The intestinal immune system -- 12. Vaccines -- 13. The immune system gone wrong -- 14. Immunodeficiency -- 15. Cancer and the immune system.
  • 2006 Springer
    Khamashta, Munther A.
  • 2013 Springer
    Hughes, Graham R. V.; Khamashta, Munther A.
    Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) responsible for 1 in 5 young (under 45) strokes a major cause of early heart attacks responsible for 1 in 5 deep vein thromboses an important cause of migraine.
  • 2008 Springer
    Dessain, Scott K.
    Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.] -- Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.] -- Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.] -- Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.] -- The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.] -- Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].
    Also available: Print – 2008
  • 2014 Springer Protocols
    Steinitz, Michael.
    Human monoclonal antibodies : the residual challenge of antibody immunogenicity / Herman Waldmann -- Technical and ethical limitations in making human monoclonal antibodies (an overview) / Mark C. Glassy and Rishab Gupta -- Therapeutic human monoclonal antibodies in inflammatory diseases / Sotirios Kotsovilis and Evangelos Andreakos -- Therapeutic human monoclonal antibodies against cancer / Jamie Jarboe, Anumeha Gupta, and Wasif Saif -- Polyclonal and monoclonal antibodies in clinic / Bharath Wootla, Aleksandar Denic, and Moses Rodriguez -- Production of human monoclonal Antibodies by the Epstein-Barr virus method / Michael Steinitz -- Humanization and simultaneous optimization of monoclonal antibody / T. Kuramochi, T. Igawa, H. Tsunoda, and K. Hattori -- Chimeric Antibodies / Kohei Kurosawa, Waka Lin, and Kunihiro Ohta -- Recombinant genetic libraries and human monoclonal antibodies / Jarrett J. Adams, Bryce Nelson, and Sachdev S. Sidhu -- Production of stabilized scFv antibody fragments in the E. coli bacterial cytoplasm / Lilach Vaks and Itai Benhar -- Construction and production of an IgG-like tetravalent bispecific antibody, IgG-single-chain Fv fusion / Dan Lu and Zhenping Zhu -- Construction of human antibody gene libraries and selection of antibodies by phage display / André Frenzel [and others] -- Antigen-specific human monoclonal antibodies from transgenic mice / Susana Magadán Mompó and África González-Fernández -- Phage display technology for human monoclonal antibodies / Cecilia Deantonio [and others] -- Antigen-specific in vitro immunization : a source for human monoclonal antibodies / Kosuke Tomimatsu and Sanetaka Shirahata -- Methods for radiolabelling of monoclonal antibodies / Vladimir Tolmachev, Anna Orlova, and Karl Andersson -- Purification of human monoclonal antibodies and their fragments / Thomas Müller-Späth and Massimo Morbidelli -- Idiotype-specific intravenous immunoglobulin (IVIG) for therapy of autoimmune diseases / Miri Blank, Tomer Bashi, and Yehuda Shoenfeld.
  • 2011 Future Med
    Franco, Eduardo L.
    Human papillomavirus vaccines / Eduardo L. Franco -- Pathobiology and immunology of human papillomavirus / Margaret Stanley -- Overview of clinical evidence : the quadrivalent vaccine Gardasil / Suzanne M Garland -- Overview of clinical evidence : Cervarix -- Tino F. Schwarz -- HPV vaccines : public health and clinical guidelines / F. Xavier Bosch -- Perspectives for prophylactic and therapeutic vaccination for HPV-induced lesions / Shreya Kanodia & W. Martin Kast.
  • 2014 Springer Protocols
    Poli, Guido; Vicenzi, Elisa.
    Virion attachment and entry : HIV gp120 env biotinylation, gp120 env, or integrin ligand-binding assay / Claudia Cicala and James Arthos -- CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5[alpha] / Gongpu Zhao and Peijun Zhang -- The fate of HIV-1 capsid : a biochemical assay for HIV-1 uncoating / Yang Yang, Jeremy Luban, and Felipe Diaz-Griffero -- The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells / Amy E. Hulme and Thomas J. Hope -- Imaging HIV-1 nuclear pre-integration complexes / Anna Cereseto and Mauro Giacca -- HIV-1 reverse transcription / Andrea Cimarelli and Jean-Luc Darlix -- RNase H : specificity mechanisms of action, and antiviral target / Karin Moelling, Felix Broecker, and John E. Kerrigan -- HIV-1 chromatin, transcription, and the regulatory protein Tat / Laurence Colin, Eric Verdin, and Carine Van Lint -- HIV-1 Rev function and RNA nuclear-cytoplasmic export / Alan Cochrane -- HIV-1 accessory proteins : Nef / Anke Heigele [and three others] -- HIV-1 accessory proteins : VpR / Richard Y. Zho and Michael I. Bukrinsky -- HIV-1 accessory proteins : Vpu and Vif / Amy Andrew and Klaus Strebel -- SIVSM/HIV-2 Vpx proteins : function and uses in the infection of primary myeloid cells / Gregory Berger and Andrea Cimarelli -- Imaging of HIV assembly and release / Barbara Müller and Jacomine Krijnse-Locker -- HIV-1 isolation from infected peripheral blood mononuclear cells / Stefania Dispinseri [and four others] -- Determination of HIV-1 co-receptor usage / Mariangela Cavarelli and Gabriella Scarlatti -- The macrophage and HIV : basic concepts and methodologies / Suzanne Gartner -- HIV infection of dendritic cells / Najla Nasr [and three others] -- Histocultures (tissue explants) in human retrovirology / Anush Arakelyan [and four others] -- Single-copy quantification of HIV-1 in clinical samples / Ann Wiegand and Frank Maldarelli -- Quantification of total HIV1-DNA in peripheral blood mononuclear cells / Christine Rouzioux, Adeline Mélard, and Véronique Avéttand-Fénoël -- HIV-1 based lentiviral vectors / Ying Poi Liu and Ben Berkhout -- Quantification of miRNA by poly(A)-RT-qPCR arrays and verification of target sites in HIV-1 using a one-LTR infectious molecular clone / Zachary A. Klase, Laurent Houzet, and Kuan-Teh Jeang -- Investigating human T cell lymphotropic retrovirus (HTLV) Tax function with molecular and immunophenotypic techniques / Greta Forlani, Roberto S. Accolla, and Giovanna Tosi -- Proviral load determination of HTLV-1 and HTLV-2 in patients' peripheral blood mononuclear cells by real-time PCR / Claudio Casoli, Elisabetta Pilotti, and Umberto Bertazzoni -- Quantitative analysis of human T-lymphotropic virus type 1 (HTLV-1) gene expression using nucleo-cytoplasmic fractionation and splice junction-specific real-time RT-PCR (qRT-PCR) / Ilaria Cavallari, Francesca Rende, and Vincenzo Ciminale.
  • 2009 Springer
    Rook, Graham A. W.
    Also available: Print – 2009
  • 2008 ScienceDirect
    Besedovsky, Hugo O.; Chrousos, George P.; Del Rey, Adriana.
  • 2012 Springer
    Rainsford, K. D.
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • 2015 Springer
    Curotto de Lafaille, Maria A.; Lafaille, Juan José.
    Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
  • 2014 Springer
    Kawa, Shigeyuki; Kawano, Mitsuhiro; Okazaki, Kazuichi; Stone, John H.; Umehara, Hisanori.
    IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.
  • 2013 Springer
    Di Padova, Franco; Quesniaux, Valérie; Ryffel, Bernhard.
    The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.
    Also available: Print – 2013
  • 2009 CRCnetBASE
    Cruse, Julius M.; Lewis, R. E.
    Also available: Print – 2009
  • 2011
    Vasey, Adrianne Elizabeth; Chawla, Ajay; Engleman, Edgar G.; Negrin, Robert S.; Utz, Paul J.
    Allogeneic hematopoietic cell transplantation (HCT) is an excellent model for the controlled study of adoptively transferred cells in the induction and progression of numerous immune responses in vivo, with the added benefit that these cells can be tracked, identified, and re-isolated. Using this model, we conducted four distinct sets of studies related to the trafficking and function of immune cells in allogeneic responses. In our first project, we focused on the early events of T cell activation leading to the induction of Graft-versus-Host Diesease (GVHD) in a murine model of major histocompatibility complex (MHC)-matched transplantation. Although it is well known GVHD occurs in MHC-matched transplants, little is known about donor T cell activation kinetics in minor-mismatched models. Yet, because these models better approximate clinical transplantation, it is critical to understand how GVHD develops across minor barriers. To investigate temporal and spatial events of GHVD development, side-by-side transplants were conducted into major and minor-mismatched recipients using hematopoietic cells from the same donor mouse strain. In both models, T cells home to nodal sites by day 3, proliferate, and exit to GVHD target tissues by day 6. Additionally, expression of homing and activation markers was equivalent for all markers examined on day 3. However, tissue migration and proliferation were reduced in the minor model. And by day 6, minor-mismatched T cells had increased CD62L retention and reduced P-selectin and CD44 expression. We also found fewer MHC-matched T cells producing interferon-[gamma] (IFN-[gamma]) and tumor necrosis factor-[alpha] (TNF-[alpha]). Our data show that very early events of donor T cell activation are similar in both models, suggesting that delays in GVHD onset across minor barriers arise from temporal differences in the effector phase, rather than the initiation phase, of GVHD. For our second project, we examined the ability of transplanted natural killer (NK) cells to impact GVHD in MHC-matched transplants as allogeneic NK cells are already known to suppress GVHD in transplants across major histocompatibility barriers. Since NK cells can lyse host antigen-presenting cells (APCs) in these transplants due to disparities in MHC class I expression between the recipient and donor, thus reducing the activation of donor T cells, it is thought that this is primary mechanism of NK-mediated reductions in GVHD. However, in MHC-matched transplants, MHC class I expression is shared between donor and host, protecting host APCs from lysis. Previous work from our laboratory has shown that NK cells can also reduce GVHD, in MHC-mismatched transplants, through the inhibition and lysis of autologous donor T cells that have upregulated expression of NKG2D activating ligands. As such, we wondered whether this mechanism may also reduce GVHD in transplants across minor histocompatibility barriers. Our data demonstrate that donor NK cells are able to improve survival and reduce GHVD disease severity in the more clinically relevant model of MHC-matched transplantation. As allorecognition and lysis of MHC-mismatched host APCs is not possible in this model, NK cells must be mediating their benefits through alternate mechanisms. Although we did find that NK cells were capable of reducing the proliferation of syngeneic T cells in an MLR using irradiated MHC-matched splenocytes as stimulators, we were unable to find evidence for the direct inhibition, or lysis, of donor T cells by NK cells in vivo. It seems likely that this was at least partially due to the much lower number of NK cells used in these studies compared to the previous reports. Additionally, as NK cells may impact T cells that are homeostatically proliferating differently then they impact T cells proliferating in response to antigen, it will be critical for future studies to clearly separate these two populations, especially given the reduced frequency of alloreactive T cells in MHC-matched models. Perhaps then we will be able to identify the mechanisms of donor NK mediated reductions in GVHD. In our third project, we studied the in vivo ability of NK cells to clear tumor. NK cells have natural cytotoxicity and cytokine production capabilities, and are known to mount potent responses against both viruses and tumor cells. Preclinical data in combination with results from clinical trials of haploidentical killer immunoglobulin-like receptor (KIR)-ligand mismatched bone marrow transplantation led to interest in the use of adoptive NK immunotherapy for the treatment of malignancy. Recent early-phase clinical trial results have shown that allogeneic NK cells can be safely administered after chemotherapy and/or irradiation but have also demonstrated limited persistence of the infused NK cells. Additionally, in the absence of control arms, it has been difficult to determine whether tumor clearance is due to the preparative regimen, or due to actual immune mediated effects. Here, using several murine models of NK-sensitive hematologic malignancy, we trace the fate of adoptively infused NK cells and show that NK cells traffic to tumor sites but fail to control tumor growth. NK cells rapidly down-regulate effector functions and activating receptor expression upon homeostatic proliferation and upon tumor exposure in syngeneic as well as allogeneic settings. This dysfunction is likely cell-intrinsic as it is accompanied by down-regulation of the canonical transcription factors Eomesodermin and T-bet, and is not impacted by depletion of regulatory T cells from the tumor milieu. These results demonstrate that NK cell capability is intrinsically limited and cannot be relied upon for adoptive anti-tumor immunotherapy. As such, novel approaches may be required in order to circumvent the described dysfunction phenotype. Lastly, we attempted to deplete dendritic cells (DCs) within the host to study impacts on the development of GVHD. To try to delineate whether there is a critical time window during which host DCs cells need to initiate GVHD, we conducted MHC-mismatched transplants into BALB/c mice that were chimeric for the CD11c DTR-GFP transgene in their hematopoietic system, to be able to control the deletion of host DCs at specific time points. Despite initial problems with DT lethality in the original transgenic mice, we were able to achieve successful, transient, depletion of host DCs using these chimeric mice made from the BM of transgenic donors. Although we found that DT treatment of transgenic mice 24 hours to harvesting their spleens for use as stimulators in an MLR greatly reduced allogeneic T cell proliferation, DT treatment of transgenic chimeric recipients prior to irradiation and transplantation with allogeneic T cells did not provide any protection from the development of GVHD, even with up to a 4 day delay in T cell administration and titrating T cell doses down to 1 x 105. In contrast, DT treated mice actually had reduced survival compared to transgenic chimeras given only PBS, suggesting that DC depletion may somehow enhance T cell proliferation. This may be partially due to negative impacts on the activation, expansion, and function of Tregs, which are known to have important cross-talk with DCs. These studies were further complicated by the fact that the chimeric transgenic mice had all previously undergone lethal TBI, as we found that previously irradiated recipients had reduced survival when transplanted with allogeneic T cells, regardless of whether or not they were transgenic of WT or whether they received DT or PBS, compared to mice that had never been irradiated previously. Additionally, since DC depletion is not 100% in these animals, we were unable to precisely determine the contribution of remaining cell types in the outcomes we observed. As such we were unable to conclude anything about the role of host DCs in the development of GVHD from these studies.
  • 2013 Springer Protocols
    Lenardo, Michael; Snow, Andrew L.
    Quantitating lymphocyte programmed cell death in vitro using simple kill assays / Lixin Zheng -- Fluorescence-activated cell sorting-based quantitation of T cell receptor restimulation-induced cell death in activated, primary human T cells / Gil Katz and Andrew L. Snow -- Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes / Joao Bosco Oliveira -- Determination of apoptosis sensitivity in specific T cell subsets from human peripheral blood by utilizing a multiparameter fluorescence-activated cell sorting-based technique / Bernice Lo and Madhu Ramaswamy -- Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation / Nelia Cordeiro and Nicolas Bidere -- Analyses of programmed cell death in dendritic cells / Min Chen, Lily Huang, and Jin Wang -- Detection of necrosis by release of lactate dehydrogenase Activity / Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa -- Assessment of CD4+ and CD8+ T cell responses using MHC class I and II tetramers / Sema Kurtulus and David Hildeman -- Homeostatic proliferation of mature T cells / Christopher E. Martin [and others] -- Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers / Liset Westera [and others] -- Real-time quantitative (RQ- )PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis / Menno C. van Zelm [and others] -- Molecular measurement of T cell receptor excision circles / Heather E. Lynch and Gregory D. Sempowski -- Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis / R. Anthony Barnitz [and others] -- Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders / Yu Zhang and Helen C. Su -- Flow cytometric measurement of SLAM-associated protein and x-linked inhibitor of apoptosis / Rebecca A. Marsh, Jack J. Bleesing, and Alexandra H. Filipovich -- In vitro suppression assay for functional assessment of human regulatory T cells / Dat Q. Tran.
  • 2009 Springer
    Krause, Walter; Naz, Rajesh K.
  • 2006 Springer
    Blumberg, R. S.; Neurath, M.
    Structure and function of the gut mucosal immune system / Reinhard Pabst and Hermann J. Rothkutter -- Functional aspects of the mucosal immune system / Cathryn Nagler-Anderson -- Recent progress in inflammatory bowel disease genetics / Judy H. Cho -- Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation / R. Balfour Sartor -- Experimental models of mucosal inflammation / Warren Strober and Ivan J. Fuss -- Overview of role of the immune system in the pathogenesis of inflammatory bowel disease / Thomas T. MacDonald and Giovanni Monteleone -- The role of the epithelial barrier in inflammatory bowel disease / Edward E.S. Nieuwenhuis and Richard S. Blumberg -- Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease / Francisco Leon ... [et al.] -- Alterations of T lymphocytes in inflammatory bowel diseases / Charles O. Elson, Yingzi Cong and Casey T. Weaver -- The B-cell system in inflammatory bowel disease / Per Brandtzaeg, Hege S. Carlsen and Trond S. Halstensen -- Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases / Claudio Fiocchi ... [et al.] -- Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease / Stephan C. Bischoff and Thomas Gebhardt -- Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease / Jonathan Braun and Stephan R. Targan -- The role of probiotics and antibiotics in regulating mucosal inflammation / Rainer Duchmann -- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease / Martin H. Holtmann and Markus F. Neurath.
    Also available: Print – 2006
  • 2014 Springer
    Pleyer, Uwe.
    These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
  • 2007 Springer
    Zhang, Jingwu.
  • 2006 ScienceDirect
    Mak, Tak W.; Saunders, Mary E.
  • 2007 Karger
    Also available: Print – 2007
  • 2015 Springer
    Lambris, J. D.
    1. Thromboinflammation in therapeutic medicine -- 2. Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions -- 3. Role of complement on broken surfaces after trauma -- 4. Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches -- 5. The lectin pathway of complement and biocompatibility -- 6. Foreign body reaction to subcutaneous implants -- 7. Molecular characterization of macrophage-biomaterial interactions -- 8. Heparan sulfate proteoglycan metabolism and the fate of grafted tissues -- 9. Xenotransplantation of cells, tissues, organs and the Greman research foundation Transregio Collaborative Research Centre 127 -- 10. Macroencapsulated pig islets correct induced diabetes in primates up to 6 months -- 11. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: points for therapeutic interventions -- 12. Cell surface engineering for reguation of immune reactions in cell therapy -- 13. Complement interception across humoral incompatibility in solid organ transplantation: a clinical perspective -- Index.
    Also available: Print – 2015
  • 2008 Springer
    Graca, Luis.
    Also available: Print – 2008
  • 2011 CRCnetBASE
    Alexander, Michael A.
    Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • 2007 Springer
    Shurin, Michael R.; Smolkin, Yuri S.
    Also available: Print – 2007
  • 2009. Karger
    Pourmand, Rahman.
    Acute neuropathies / Bromberg, M.B. -- Chronic neuropathies : chronic inflammatory demyelinating neuropathy and its variants / Ramchandren, S., Lewis, R.A. -- Nonsystemic vasculitic neuropathy : update on diagnosis, classification, pathogenesis, and treatment / Collins, M.P., Periquet-Collins, I. -- Dysimmune neuropathy / Kwan, J.Y. -- Autoimmune autonomic ganglionopathy / Winston, N., Vernino, S. -- Myasthenia gravis with anti-acetylcholine receptor antibodies / Meriggioli, M.N. -- Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis / Muppidi, S., Wolfe, G.I. -- Lambert-Eaton myasthenic syndrome / Pourmand, R. -- Idiopathic inflammatory myopathies / Dimachkie, M.M., Barohn, R.J. -- Stiff person syndrome / Duddy, M.E., Baker, M.R.
  • 2008 Springer
    Vajdy, Michael.
  • 2013 Cold Spring Harb Lab Press
    O'Garra, Anne.
    Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.
  • 2013 Springer
    Malyshev, Igor.
    A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • 2015 WHO
    Module 1. Target diseases and vaccines -- Module 2. The vaccine cold chain -- Module 3. Ensuring safe injections -- Module 4. Microplanning for reaching every community -- Module 5. Managing an immunization session -- Module 6. Monitoring and surveillance -- Module 7. Partnering with communities.
    Also available: Print – 2015
  • 2002 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2002 NAP
    McCormick, Marie C.; Stratton, Kathleen R.; Wilson, Christopher B.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2013 Springer
    Selvarajoo, Kumar.
    Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.
  • 2007 CRCnetBASE
    Van Emon, Jeanette M.
    Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • 2013 ScienceDirect
    Wild, David.
    How to use this book / David Wild -- Immunoassay for beginners / David Wild -- Immunoassay performance measures / Chris Davies -- Principles of competitive and immunometric assays (including ELISA) / Chris Davies -- Non-competitive immunoassays for small molecules : the anti-complex and selective antibody systems / Colin H. Self ... [et al.] -- Homogeneous immunoassays / Edwin F. Ullman -- Lateral flow immunoassay systems : evolution from the current state of the art to the next generation of highly sensitive, quantitative rapid assays / Brendan O'Farrell -- Ambient analyte assay / Roger Ekins -- Free analyte immunoassay / Nic D. Christofides -- Qualitative immunoassay : features and design / Jianwen He, Simon Parker -- Detection of antibodies relevant to infectious disease / Steven Binder, Jennifer A. Isler -- Microsphere-based multiplex immunoassays : development and applications using Luminex® Xmap® technology / Sherry A. Dunbar, Michaela R. Hoffmeyer -- Lab-on-a-chip, micro- and nanoscale immunoassay systems, and microarrays / Simon Rattle ... [et al.] -- Immunological biosensors / Jason Reed, James K. Gimzewski -- Surface plasmon resonance in binding site, kinetic, and concentration analyses / Robert Karlsson -- Measurement of single protein molecules using digital ELISA / David M. Rissin, David H. Wilson, David C. Duffy -- Antibodies / Eryl Liddell -- Signal generation and detection system (excluding homogeneous assays) / Ian Weeks, Larry J. Kricka, David Wild -- Separation systems / David Wild, Wlad Kusnezow -- Conjugation methods / Alastair H. Dent -- Standardization and calibration / David Wild, Chris Sheehan -- Calibration curve fitting / John Dunn, David Wild -- The foundations of immunochemistry / Robert F. Ritchie -- Immunohistochemistry and immunocytochemistry / Simon Renshaw -- Practical guide to ELISA development / Jianwen He -- Method evaluation : a practical guide / Chris Sheehan, Jianwen He, Mari Smith -- Interferences in immunoassay / Jason Y. Park, Larry J. Kricka -- Immunoassay development in the in vitro diagnostic industry / Doug Brandt, Steve Figard -- Sample collection, including participant preparation and sample handling / Colin Wilde ... [et al.] -- Quality assurance / Catharine M. Sturgeon -- Point-of-care testing / James H. Nichols -- Choosing an automated immunoassay system / Lori J. Sokoll -- Immunoassay troubleshooting guide / David Wild, Jianwen He -- Introduction to immunoassay product technology in clinical diagnostic testing / David Wild, Chris Sheehan, Steve Binder -- Market trends / David Huckle -- Lateral flow and consumer diagnostics / Sarah Tiplady -- Consumer diagnostics : Clearblue pregnancy and fertility testing / Sarah Tiplady -- The Triage® system / Thomas I. Koshy, Kenneth F. Buechler -- Stratus® CS Acute Care[TM] STAT fluorometric analyzer / Amy Sarli, W.N. McLellan -- IMX® / Kent Ford -- AXSYM® / Theresa Donahoe -- Abbott Architect® family of analyzers / Frank A. Quinn, David A. Armbruster -- Advia Centaur® XP / Jean Metzar -- Immulite® and Immulite 1000 / Arthur L. Babson -- VITROS® ECiQ Immunodiagnostic System, VITROS® 3600 Immunodiagnostic System, and VITROS® 5600 Integrated System / John W. Backus, David Wild -- VITROS® Immuno-Rate and Microtip[TM] assays / John W. Backus, Susan J. Danielson, David A. Hilborn -- Access 2 / Katherine M. Leith -- DXI 600 and DXI 800 / Katherine M. Leith -- Elecsys® immunoassay systems / Mary Beth Myers -- PRISM[TM] / Dinesh Shah, Jim Stewart -- Phadia Laboratory Systems / Angela Gore, Gareth Evans, Mats Rilvën -- Immunoassay applications in veterinary diagnostics / Thomas P. O'Connor, Jr. ... [et al.] -- Ligand binding assays in drug development / Jeffrey M. Sailstad ... [et al.] -- Clinical concepts / Chris Davies -- Thyroid / Rhys John ... [et al.] -- The adrenal cortex / Les Perry, Sami Medbak -- Bone and calcium metabolism / William D. Fraser, Kay W. Colston, John C. Stevenson -- Infertility / Michael J. Wheeler -- In vitro fertilization and embryo transfer (IVF-ET) / Richard Fleming, Sherry Faye -- Hirsutism and virilization in the female / Michael J. Wheeler -- Pregnancy / Kevin Spencer, Tim Chard -- Growth and growth hormone deficiency / Gill Rumsby ... [et al.] -- Diabetes mellitus / Penny Clark, Tim McDonald -- Hematology / Katy Evans ... [et al.] -- Cardiac markers / Deborah French, Alan H.B. Wu -- Cancer markers / Hoon H. Sunwoo, Mavanur R. Suresh -- Allergy / Marcos Alcocer, Lars Yman -- Autoimmune disease / David F. Keren -- Gastrointestinal tract / Arne Reseth ... [et al.] -- Hepatitis / Ravi Kaul -- HIV-1 and HIV-2 : causative agents of AIDS / Catherine A. Brennan, Sushil G. Devare -- Viral diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Bacterial diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Parasites and fungi / STeven R. Binder, Patrice D. Sarfati -- Therapeutic drug monitoring (TDM) / Philip A. Routledge, Alun D. Hutchings -- Drugs of abuse / Alun D. Hutchings, Brian Widdop.
  • 2006 Springer
    Colonna, M.; Vivier, E.
    Also available: Print – 2006
  • 1978-
    Atassi, M. Z.; Stavitsky, Abram Benjamin.
  • 2010 Springer
    Burry, Richard W.
  • 2015 Springer Protocols
    Lossi, Laura; Merighi, Adalberto.
    Machine generated contents note: 1.The Evolution of Immunocytochemistry in the Dissection of Neural Complexity / Laura Lossi -- pt. I Immunocytochemistry in Non-Mammalian Brain -- 2.Immunofluorescence and Genetic Fluorescent Labeling Techniques in the Drosophila Nervous System / Christian Wegener -- 3.Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris / Graziano Fiorito -- 4.Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish Brain / Yoshihiro Yoshihara -- pt. II Detection of Cell Proliferation and Neurogenesis -- 5.Immunocytochemical Phenotype of Differentiating Neurons / Antonio Carai -- 6.Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus / Oliver von Bohlen und Halbach -- 7.Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations / Pasko Rakic --
  • 2006 Springer
    Brassat, David; Oksenberg, Jorge R.
    HLA and autoimmunity : structural basis of immune recognition / Kai W. Wucherpfennig -- Genomic variation and autoimmune disease / Silke Schmidt and Lisa F. Barcellos -- Endocrine diseases : type I diabetes mellitus / Regine Bergholdt, Michael F. McDermott, and Flemming Pociot -- Endocrine diseases : Graves' and Hashimoto's diseases / Yoshiyuki Ban and Yaron Tomer -- Central and peripheral nervous system diseases / Dorothée Chabas, Isabelle Cournu-Rebeix, and Bertrand Fontaine -- Immunogenetics of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus / Allison Porter and J. Lee Nelson -- Gastroenterologic and hepatic diseases / Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux -- Inflammatory myopathies : dermatomyositis, polymyositis, and inclusion body myositis / Renato Mantegazza and Pia Bernasconi -- Hematologic diseases : autoimmune hemolytic anemia and immune thrombocytopenic purpura / Mattias Olsson ... [et al.] -- Genetics of autoimmune myocarditis / Mehmet L. Guler, Davinna Ligons, and Noel R. Rose.
  • 2008 Springer
    Møller, Eva Horn; Weert, Marco van de.
  • 2008 Springer
    Brusic, Vladimir; Ranganathan, Shoba; Schönbach, Christian.
    IMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
  • 2007 Springer Protocols
    Flower, Darren R.
  • 2014 Springer Protocols
    De, Rajat K.; Tomar, Namrata.
    Part I: Immunoinformatics: transition from basic biology to informatics -- 1. A brief outline of the immune system / Namrata Tomar and Rajat K. De -- 2. Crosstalk between the metabolic and immune systems / Namrata Tomar and Rajat K. De -- 3. Immunoinformatics: a brief review / Namrata Tomar and Rajat K. De -- Part II: Databases -- 4. Immunoinformatics of the V, C and G domains: IMGT® definitive system for IG, TR and IgSF, MH and MhSF / Marie-Paule Lefranc -- 5. IMGT/HLA and the immuno polymorphism database / James Robinson, Jason A. Halliwell, and Steven G.E. Marsh -- 6. Databases for T-cell epitopes / Chun-Wei Tung -- 7. Databases for B-cell epitopes / Juan Liu and Wen Zhang -- 8. Antigen-Antibody Interaction Database (AgAbDb): a compendium of antigen-antibody interactions / Urmila Kulkarni-Kale, Snehal Raskar-Renuse, Girija Natekar-Kalantre, and Smita A. Saxena -- 9. Allergen databases / Gaurab Sircar, Debasree Sarkar, Swati Gupta Bhattacharya, and Sudipto Saha -- Part III: Tools for prediction -- 10. Prediction of conformational B-cell epitopes / Wen Zhang, Yanqing Niu, Yi Xiong, and Meng Ke -- 11. Computational prediction of B cell epitopes from antigen sequences / Jianzhao Gao and Lukasz Kurgan -- 12. Machine learning based methods for prediction of linear B-cell epitopes / Hsin-Wei Wang and Tun-Wen Pai -- 13. Mimotope-based prediction of B-cell epitopes / Jian Huang, Bifung He, and Peng Zhou -- 14. Hybrid methods for B-cell epitope prediction: approaches to the development and utilization of computational tools for practical applications / Salvador Eugenio C. Caoili -- 15. Building classifier ensembles for B-cell epitope prediction / Yasser El-Manzalawy and Vasant Honavar -- 16. Multiplex peptide-based B-cell epitope mapping / Sanne M.M. Hensen, Merel Derksen, and Ger J.M. Pruijn -- 17. Classification of Human Leukocyte Antigen (HLA) supertypes / Mingjun Wang and Mogens H. Claesson -- 18. Customized predictions of peptide-MHC binding and T-cell epitopes using EPIMHC / Magdalena Molero-Abraham, Esther M. Lafuente, and Pedro Reche -- 19. T-cell epitope prediction methods: an overview / Dattatraya V. Desai and Urmila Kulkarni-Kale -- 20. Computational antigenic epitope prediction by calculating electrostatic desolvation penalties of protein surfaces / Sebastien Fiorucci and Martin Zacharias -- 21. In silico prediction of allergenic proteins / Gaurab Sircar, Bodhisattwa Saha, Swati Gupta Bhattacharya, and Sudipto Saha -- 22. Prediction of virulence factors using bioinformatics approaches / Rupanjali Chaudhuri and Srinivasan Ramachandran -- Part IV: Systems biology approaches in immunoinformatics -- 23. A systems biology approach to study systemic inflammation / Bor-Sen Chen and Chia-Chou Wu -- 24. Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models / Shailbala Singh, Pramod Nehete, Patrick Hanley, Bharti Nehete, Guojun Yang, Hong He, Scott M. Anthony, Kimberly Schluns, and K. Jagannadha Sastry -- 25. Immunoinformatics and systems biology in personalized medicine / Guillermo Lopez-Campos, Jesús F. Bermejo-Martin, Raquel Almansa, and Fernando Martin-Sanchez -- Part V: Applications of immunoinformatics -- 26. The role of small RNAs in vaccination / Ajeet Chaudhary and Sunil Kumar Mukherjee -- 27. Structure-based clustering of Major Histocompatibility Complex (MHC) proteins for broad-based T-cell vaccine design / Joo Chuan Tong, Tin Wee Tan, and Shoba Ranganathan -- 28. Immunoinformatics, molecular modeling, and cancer vaccines / Seema Mishra and Subrata Sinha -- 29. Investigating host pathogen behavior and their interaction using genome-scale metabolic network models / Priyanka P. Sadhukhan and Anu Raghunathan -- 30. Mathematical models of HIV replication and pathogenesis / Dominik Wodarz.
  • 2011 Springer
    Marincola, Francesco M.; Wang, Ena.
    pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection.
  • 2010 Springer
    Batista, Facundo; Saito, Takashi.
    Insights into function of the immunological synapse from studies with supported planar bilayers / M.L. Dustin -- Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions / J. Doh and M.F. Krummel -- Molecular and cellular dynamics at the early stages of antigen encounter: the B-cell immunological synapse / Y.R. Carrasco -- Inhibitory and regulatory immune synapses / P. Eissmann and D.M. Davis -- The immunological synapse, TCR microclusters, and T cell activation / T. Yokosuka and T. Saito -- Signaling amplification at the immunological synapse / A. Viola, R.L. Contento and B. Molon -- Multiple microclusters: diverse compartments within the immune synapse / S.C. Bunnell -- A conformation-induced oligomerization model for B cell receptor microclustering and signaling / P. Tolar and S.K. Pierce -- Co-receptors and recognition of self at the immunological synapse / N.R. Gascoigne ... [et al.] -- Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses / A. Alcover and M.I. Thoulouze -- Plasticity of immunological synapses / S. Valitutti and L. Dupre -- APC, T cells, and the immune synapse / P. Reichardt, B. Dornbach and M. Gunzer.
    Also available: Print – yyyy
  • 2007 Springer Protocols
    Fairchild, Paul J.
  • 2002 NCBI Bookshelf
    Frank, Steven A.
  • 2005 Springer
    Langhorne, J.
    The dissection of CD8 T cells during liver-stage infection / U. Krzych and R.J. Schwenk -- Early interactions between blood-stage Plasmodium parasites and the immune system / B.C. Urban, R. Ing, and M.M. Stevenson -- Longevity of the immune response and memory to blood-stage malaria infection / A.H. Achtman ... [et al.] -- Experimental models of cerebral malaria / C. Engwerda ... [et al.] -- Glycosylphosphatidylinositols in malaria pathogenesis and immunity : potential for therapeutic inhibition and vaccination / C.S. Boutlis ... [et al.] -- The immunology and pathogenesis of malaria during pregnancy / J.G. Beeson and P.E. Duffy.
    Also available: Print – 2005
  • 2015 Springer
    Müller, N.; Myint, Aye-Mu; Schwarz, Markus J.
    Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
  • 2009
    Turgeon, Mary Louise.
    Status: Not Checked OutLane Catalog Record
  • 2012 ScienceDirect
    Flaherty, Dennis K.
    With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
  • 2014 Springer
    Massoud, Ahmad; Rezaei, Nima.
    An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
  • 2007 Springer
    Brown, Gordon D.; Netea, Mihai G.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2010 ScienceDirect
    Kabelitz, Dieter; Kaufmann, S. H. E.
    1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2006 Springer
    Mor, Gil.
    Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] -- Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov -- Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • 2014 Springer
    Weissenbacher, E. R.
    Fundamentals of immunology: Concepts of innate and specific immunity -- Mucosal immunology -- General immunology of the genital tract: Distinct features of the genital mucosal tissue -- Functions and regulation of innate immune responses in the human reproductive tract -- Functions and regulation of adaptive humoral and cell-mediated immunity in the female genital tract -- Immunization studies -- Immunology of menstruation {u2013} menstruation as an inflammatory process -- Immunology of genital tract infections: Viral infections of the genital tract -- Bacterial infections of the genital tract -- Candidiasis -- Trichomoniasis -- Immunology in reproductive medicine: Immunology of pregnancy -- Immunologic infertility -- Immunocontraceptive approaches.
  • 2013 Springer
    Santambrogio, Laura.
    Immunology of the Lymphatic System is a comprehensive study of the lymphatic system and its immunological role. It begins with lymphatic capillaries, their origin and development. It addresses lymph circulation, in general, with a special emphasis on lymph circulation in parenchymal organs. The next section focuses on lymph nodes, subcortical circulation and the conduit system. It discusses organs with no lymphatic system, such as the brain. Finally, it covers lymph composition and cells in the lymph. While primarily basic research, the volume touches upon elements of the clinical, as well, broadening its scope and appeal.
  • 2008 Springer
    Beutler, Bruce.
    The forward genetic dissection of afferent innate immunity / B. Beutler and E.M. Moresco -- Genetic analysis of resistance to infections in mice: A/J meets C57BL/6J / J.F. Marquis and P. Gros -- Host defenses against human papillomaviruses: lessons from epidermodysplasia verruciformis / G. Orth -- Innate resistance to flavivirus infections and the functions of 2'-5' oligoadenylate synthetases / T. Mashimo, D. Simon-Chazottes and J.L. Guenet -- Cmv1 and natural killer cell responses to murine cytomegalovirus infection / A.A. Scalzo and W.M. Yokoyama -- Genetic dissection of host resistance to Mycobacterium tuberculosis: the sst1 locus and the Ipr1 gene / I. Kramnik -- Scurfy, the Foxp3 locus, and the molecular basis of peripheral tolerance / M.W. Appleby and F. Ramsdell -- Fevers, genes, and innate immunity / J.G. Ryan and D.L. Kastner -- Itchy mice: the identification of a new pathway for the development of autoimmunity / L.E. Matesic, N.G. Copeland and N.A. Jenkins -- TIM gene family and their role in atopic diseases / D.T. Umetsu ... [et al.].
    Also available: Print – 2008
  • 2013 ClinicalKey
    Male, David K.
    This textbook teaches the basic and clinical immunology concepts.
  • 2006
    Brostoff, Jonathan; Male, David K.; Roitt, Ivan Maurice; Roth, David B.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Flower, Darren R.; Perrie, Yvonne.
    This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
  • v. 2-, 2009- Springer
  • 2014 CRCnetBASE
    Aggarwal, Bharat B.; Heber, David.
    Chapter 1. Evolution of innate and adaptive immunity / David Heber and Bharat B. Aggarwal -- chapter 2. Cellular mechanisms of cytokine activation / David Heber and Bharat B. Aggarwal -- chapter 3. Cellular lipids and inflammation / David Heber and Susanne Henning -- chapter 4. Biomarkers of inflammation and the Western diet / David Heber and Susanne Henning -- chapter 5. Phytochemicals and immune function / David Heber -- chapter 6. Genetic and environmental modifiers of immune function / David Heber -- chapter 7. Cancer and inflammation / David Heber -- chapter 8. Abdominal obesity : pathophysiology and related metabolic complications / Ana F.T.A. Junqueria and Caroline M. Apovian -- chapter 9. Type 2 diabetes and inflammation / Zhaoping Li and David Heber -- chapter 10. Heart disease and inflammation / Kaveh Daniel Navab -- chapter 11. Chronic kidney disease and inflammation / Karl J. Neff and Carel Le Roux -- chapter 12. Alzheimer's disease and inflammation / Stephen T. Chen and Gary W. Small -- chapter 13. Nutrition in autoimmunity : a focus on systemic lupus erythematosus and rheumatoid arthritis / Maureen McMahon -- chapter 14. Asthma and inflammation / Andre Nel and David Heber -- chapter 15. Muscle and immune function / Anthony Thomas and David Heber -- chapter 16. Approaches to reducing abdominal obesity / Zhaoping Li and David Heber -- chapter 17. Barriers to fruit and vegetable consumption and practical strategies for increasing fruit and vegetable intake / Susan Bowerman -- chapter 18. Healthy fats and oils : balancing omega-3 and omega-6 acids in tissues / Bill Lands -- chapter 19. Spices and dietary supplements with anti-inflammatory activity / Bharat B. Aggarwal and David Heber.
  • 2015 Karger
    Coukos, George; Michielin, Olivier.
    Immunotherapies in early and advanced renal cell cancer / Kasenda, B., Larkin, J., Gore, M. -- Immunotherapy of brain tumors / Dutoit, V., Migliorini, D., Walker, P.R., Dietrich, P.-Y. -- Immunotherapy of melanoma / Snyder, A., Zamarin, D., Wolchok, J.D. -- Immunotherapy of breast cancer / Criscitiello, C., Curigliano, G. -- Current developments in actively personalized cancer vaccination with a focus on RNA as the drug format / Diken, M., Kreiter, S., Kloke, B., Sahin, U. -- Immune checkpoint inhibitors / Haanen, J.B.A.G., Robert, C. -- Radiotherapy and immunotherapy : improving cancer treatment through synergy / Reynders, K., De Ruysscher, D. -- Combinations therapies / Reinmuth, N., Reck, M. -- Promise of immunotherapy in lung cancer / Shanker, A., Dikov, M.M., Carbone, D.P. -- T cell engineering / Pircher, M., Schirrmann, T., Petrausch, U.
  • 2008 Springer
    Khan, Manzoor M.
  • 2006 ScienceDirect
    O'Hagan, Derek T.; Schijns, Virgil E. J. C.
    Microparticles as vaccine delivery systems / Derek T. O'Hagan -- MF59: a safe and potent adjuvant for human use / Audino Podda, Giuseppe Del Giudice, and Derek T. O'Hagan -- Development and evaluation of AS04, a novel and improved adjuvant system containing MPL and aluminium salt / Nathalie Garçon, Marcelle van Mechelen, and Martine Wettendorff -- Virosomes for vaccine delivery / Ian C. Metcalfe and Reinhard Glück -- The ISCOMATRIX adjuvant / Debbie Drane and Martin J. Pearse -- Mineral adjuvants / Erik B. Lindblad -- Mucosal adjuvants based on cholera toxin and E. coli heat-labile enterotoxin / Jan Holmgren ... [et al.] -- Transcutaneous immunization using the heat-labile enterotoxin of E. coli as an adjuvant / Richard T. Kenney and Gregory M. Glenn -- T cell adjuvants and novel strategies for their identification / Laurence Van Overvelt and Philippe Moingeon -- Vaccination to treat noninfectious diseases: surveying the opportunities / Stephen W. Martin and Martin F. Bachmann -- Clinical evaluation of adjuvants / Jakub K. Simon and Robert Edelman -- Regulatory considerations in the nonclinical safety assessment of adjuvanted preventive vaccines / Elizabeth M. Sutkowski and Marion F. Gruber. Unravelling "the immunologist's dirty little secret" / Virgil E.J.C. Schijns -- Dendritic cells as targets and tools in vaccines / Imerio Capone, Paola Rizza, and Filippo Belardelli -- Host-derived molecules as adjuvants / Tom Barr, Jennifer Carlring, and Andrew W. Heath -- Innate immune mechanisms and the identification of immune potentiators as vaccine adjuvants / Achal Pashine, Jeffrey B. Ulmer, and Nicholas M. Valiante -- CpG oligodeoxynucleotides as vaccine adjuvants / Michael J. McCluskie and Risini D. Weeratna -- Toll-like receptor 4 agonists as vaccine adjuvants / David H. Persing ... [et al.] -- Immunomodulatory adjuvants from Quillaja saponaria / Charlotte Read Kensil --
    Also available: Print – 2006
  • 2013 Springer Protocols
    Fulton, Kelly M.; Twine, Susan M.
    Introduction to the immune system / Scott McComb ... [et al.] -- Immunoproteomics : current technology and applications / Kelly M. Fulton and Susan M. Twine -- Antigen identification using SEREX / Ugur Sahin and Özlem Türeci -- Antigen discovery using whole-genome phage display libraries / Elisa Beghetto and Nicola Gargano -- Methods and applications of serological proteome analysis / Kelly M. Fulton ... [et al.] -- Pre-absorbed immunoproteomics : a novel method for the detection of bacterial surface proteins / Guangjin Liu, Wei Zhang, and Chengping Lu -- Identification of the antigen content of electroimmunoprecipitates / N. Helena Beyer and Niels H.H. Heegaard -- Immunoproteomics approach to screen the antigenicity of the influenza virus / Kevin M. Downard -- In vivo microbial antigen discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections / Sindy J. Chaves ... [et al.] -- Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies / Alexander Nøstdal and Hans H. Wandall -- Enrichment and characterization of glycopeptide epitopes from complex mixtures / Luc Tessier, Kelly M. Fulton, and Susan M. Twine -- Whole-cell MALDI-TOF mass spectrometry : a tool for immune cell analysis and characterization / Richard Ouedraogo ... [et al.] -- Cell-based arrays for the identification of interacting polypeptide domains or epitopes / Richard H. Maier, Christina J. Maier, and Kamil Önder -- Identification and quantitation of MHC class II-bound peptides from mouse spleen dendritic cells by immunoprecipitation and mass spectrometry analysis / Leonia Bozzacco and Haiqiang Yu -- Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification / Fei Wen and Huimin Zhao -- Profiling of cytokine and chemokine responses using multiplex bead array technology / Greg Harris and Wangxue Chen -- Preparation of the low molecular weight serum proteome for mass spectrometry analysis / Timothy J. Waybright ... [et al.] -- Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry / Theodoros A. Koutroukides ... [et al.] -- Genome-based bioinformatic prediction of major histocompatibility complex (MHC) epitopes / Simon J. Foote -- Structure-based prediction of major histocompatibility complex (MHC) epitopes / Andrew J. Bordner -- Prioritization of therapeutic targets of inflammation using proteomics, bioinformatics, and in silico cell-cell interactomics / Arsalan S. Haqqani and Danica B. Stanimirovic -- Commercial considerations for immunoproteomics / Scott M. Ferguson.
  • 2015 Springer Protocols
    Shaw, Albert C.
    Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.
  • 2012 Springer
    Thiel, Andreas.
  • 2013 Springer
    Bosch, Jos A.; Lord, Janet M.; Phillips, Anna C.
    This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.
  • 2012 Future Med
    Cervera, Ricard; Meroni, Pier-Luigi; Shoenfeld, Yehuda.
    Immunotherapeutic agents for SLE / Yehuda Shoenfeld, Pier Luigi Meroni & Ricard Cervera -- Immunopathogenesis of SLE and drug targets / Arvind Kaul, David D'Cruz & Graham R.V. Hughes -- Rituximab in SLE / Cándido Díaz-Lagares, Manuel Ramos-Casals & Munther A. Khamashta -- Belimumab in SLE / Ricard Cervera & Gerard Espinosa -- Epratuzumab in SLE / David M. Goldenberg & Daniel J. Wallace -- Intravenous immunoglobulin therapy for SLE / Ziv Rozman & Gisele Zandman-Goddard -- Other novel immunotherapeutic agents in the pipeline and future directions / Ana M. Bertoli & Graciela S. Alarcón -- Index.
  • 2007 Springer
    Radbruch, A.
  • 2015 ScienceDirect
    Fisher, Paul B.; Wang, Xiang-Yang.
  • 2006 Springer
    Disis, Mary L.
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • 2010 Springer Protocols
    Yotnda, Patricia.
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • 2012 Springer
    Dietert, Rodney R.; Luebke, Robert W.
    Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
  • 2007 CRCnetBASE
    House, Robert V.; Kimber, Ian; Luebke, Robert W.
  • v.1, 2004 ScienceDirect
    Descotes, Jacques.
    v. 1. Principles and methods of immunotoxicology.
  • 2007 Springer
    Flower, Darren R.; Timmis, Jonathan.
  • 2012 Springer
    Stein-Streilein, Joan.
    The Eye as a model for immune privilege -- Immune privilege of the testis: meaning, mechanisms, and manifestations -- The Role of intrauterine immune privilege in perinatal infectious diseases -- The Liver as an immune-privileged site -- Immune homeostasis of the lung: the role of regulatory NKT cells in asthma -- Immune homeostasis of the gut.
  • 2013 Springer Protocols
    De Nardo, Christine M.; Latz, Eicke.
    Assessing [beta]-amyloid-induced NLRP3 inflammasome activation in primary microglia / Mareike Schnaars, Hannes Beckert, and Annett Halle -- Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP / Clara Westwell-Roper [and others] -- Assessment and quantification of crystal-induced lysosomal damage / Peter Duewell and Eicke Latz -- Assessment of inflammasome activation in primary human immune cells / Theo S. Plantinga, Leo A.B. Joosten, and Mihai G. Netea -- NLRP3 inflammasome activation and cytotoxicity induced by particulate adjuvants / Marie Yang [and others] -- Measuring inflammasome activation in response to bacterial infection / Petr Broz and Denise M. Monack -- Detection of pyroptosis by measuring released lactate dehydrogenase activity / Manira Rayamajhi, Yue Zhang, and Edward A. Miao -- ASC speck formation as a readout for inflammasome activation / Andrea Stutz [and others] -- Immunoblotting for active caspase-1 / Christopher Jakobs [and others] -- Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1[alpha], IL-1[beta], and caspase-1 / Katharina S. Schneider, Christina J. Thomas, and Olaf Gross -- Reconstituting the NLRP1 inflammasome in vitro / Benjamin Faustin and John C. Reed -- Assessing ATP binding and hydrolysis by NLR proteins / Jinyao Mo and Joseph A. Duncan -- Blue native polyacrylamide gel electrophoresis to monitor inflammasome assembly and composition / Eric M. Kofoed and Russell E. Vance -- Analysis of microbiota alterations in inflammasome-deficient mice / Eran Elinav, Christoph A. Thaiss, and Richard A. Flavell -- Quantification of adipose tissue leukocytosis in obesity / Ryan Grant [and others] -- In vivo evaluation of neutrophil recruitment in response to sterile particulates / Tamiko Yanagida, Kaoru Orihashi, and Hajime Kono.
  • 2011 Springer
    Couillin, Isabelle; Martinon, Fabio; Pétrilli, Virginie.
  • 2014 ScienceDirect
    Bagchi, Debasis; Rahman, Irfan.
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
  • 2012 Springer
    Grundtman, Cecilia; Wick, G.
    Ch. 1. Historical reflections on the inflammatory aspects of atherosclerosis -- Ch. 2. Morphology of atherosclerotic lesions -- Ch. 3. Clinical manifestations of atherosclerosis -- Ch. 4. Intra-aortic hematopoietic cells -- Ch. 5. The vascular-associated lymphoid tissue (VALT) -- Ch. 6. Vascular endothelial cells as immunological targets in atherosclerosis -- Ch. 7. The role of adhesion molecules and intimal dendritic cells in the initiation of atherosclerosis -- Ch. 8. Animal models of atherosclerosis -- Ch. 9. A Darwinian-evolutionary concept for atherogenesis: the role of immunity to HSP60 -- Ch. 10. Mediators of vascular inflammation -- Ch. 11. Pentraxins and atherosclerosis -- Ch. 12. Interleukin-33 and atherosclerosis -- Ch. 13. Proteomics of atherosclerosis -- Ch. 14. Adipokines, inflammation, and atherosclerosis -- Ch. 15. Natural antibodies and atherosclerosis -- Ch. 16. NK/NKT cells and atherosclerosis -- Ch. 17. Macrophages and atherosclerosis -- Ch. 18. Host pattern recognition receptors (toll-like receptors, RIG-I-Like receptors, NOD-like receptors) and atherosclerosis -- Ch. 19. Humoral antibodies -- Ch. 20. Adaptive T Cell immunity -- Ch. 21. Immunity to low-density lipoprotein -- Ch. 22. Extracellular matrix and smooth muscle cells -- Ch. 23. The role of infection in atherosclerosis and in plaque stability -- Ch. 24. Inflammatory biomarkers -- Ch. 25. Atherosclerosis in rheumatic diseases -- Ch. 26. Anti-inflammatory therapeutic approaches -- Ch. 27. Vaccination against atherosclerosis -- Ch. 28. Endocrinological aspects of atherosclerosis -- Ch. 29. Imaging of atherosclerosis -- Ch. 30. Future directions of atherosclerosis research and translation into clinical application -- Ch. 31. Controversies and open questions -- Index.
  • 2014 Springer
    Aggarwal, Bharat B.; Gupta, Subash Chandra; Sung, Bokyung.
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
    Also available: Print – 2014
  • v. 1-2, 2009 Springer Protocols
    v. 2, 2009 Springer Protocols
    Kozlov, Serguei V.
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • 2013 Karger
    Halaris, Angelos; Leonard, B. E.
    Basic aspects of the immunology of neuroinflammation / Wohleb, E.S.; Godbout, J.P. -- Stress and neuroinflammation / Grippo, A.J., Scotti, M.-A.L. -- Role of inflammation in depression : implications for phenomenology, pathophysiology and treatment / Raison, C.L., Miller, A.H. -- Virus infection as a cause of inflammation in psychiatric disorders / Bechter, K. -- Inflammation, neurotoxins and psychiatric disorders / Myint, A.-M. -- Essential fatty acids as potential anti-inflammatory agents in the treatment of affective disorders / Song, C. -- The brain-gut axis : a target for treating stress-related disorders / Scott, L.V., Clarke, G., Dinan, T.G. -- The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs / Arolt, V., Ambrée, O. -- Inflammation as the cause of the metabolic syndrome in depression / Leonard, B.E. -- Glucocorticoids and inflammation : a double-headed sword in depression? / Horowitz, M.A. ... [et al.] -- Co-morbidity between cardiovascular pathology and depression : role of inflammation -- Halaris, A. -- Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome -- Maes, M. -- Peripheral inflammation and cognitive aging -- Lim, A., Krajina, K., Marsland, A.L. -- Inflammation in suicidality : implications for novel treatment options / Janelidze, S., Brundin, L.
  • 2012 CRCnetBASE
    Aggarwal, Bharat B.; Guha, Sushovan; Krishnan, Sunil.
    "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
    Also available: Print – 2015
  • 2015 Springer
    Pugia, Michael.
    Part 1. Introduction -- 1. Impact of inflammation and the innate immunity response in obesity mediated diabetes (lit review) -- Part 2. Impact of complement on diabetic disease -- 2. Complement and Complement Regulatory Proteins in Diabetes -- Part 3. Role of C terminal fragment of adiponectin receptor in inhibition of insulin degradation -- 3. Development of adiponectin receptor C terminal fragment bioassays -- 4. Protease inhibition and biological distribution of the C terminal fragment of adiponectin receptor -- 5. Cell & biological models for the C terminal fragment of adiponectin receptor -- 6. C-Terminal fragment of adiponectin receptor clinical correlations -- Part 4. Uristatin assay for prediction of renal and other clinical events -- 7. Uristatin immunoassay usage in glomerular nephritis assessment -- 8. Acute Response of Uristatin in Surgery -- 9. Cardiovascular and metabolic syndrome impact on uristatin -- 10. Uristatin anti-inflammatory cellular signaling -- Part 5. Summary -- 11. Overview of progress in new markers for diabetes inflammation (Literatue Review).
    Also available: Print – 2015
  • 2014 Springer
    Compans, Richard W.; Oldstone, Michael B. A.
    This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
  • 2015 Springer
    Compans, Richard W.; Oldstone, Michael B. A.
    Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
  • 2011 Springer
    Del Giudice, Giuseppe; Rappuoli, Rino.
    pt. 1. Evolution and epidemiology -- pt. 2. Immunity and vaccine strategies -- pt. 3. Economic and social implications.
  • 2008 Springer
    Yefenof, Eitan.
  • 2014 Springer Protocols
    Anders, Hans-Joachim; Migliorini, Adriana.
    Detection of RNA modifications by HPLC analysis and competitive ELISA / Gernot Nees, Andreas Kaufmann, and Stefan Bauer -- Enzymatic synthesis and purification of a defined RIG-I ligand / Marion Goldeck ... [et al.] -- Crystallization of mouse RIG-I ATPase domain : in situ proteolysis / Filiz Civril and Karl-Peter Hopfner -- Isolation of RIG-I-associated RNAs from virus-infected cells / Andreas Schmidt ... [et al.] -- Structure modeling of Toll-Like Receptors / Jing Gong and Tiandi Wei -- Nucleic acid recognition in dendritic cells / Alexander Heiseke, Katharina Eisenächer, and Anne Krug -- Viral nucleic acid recognition in human nonimmune cells : in vitro systems / Andrea Ribeiro and Markus Wörnle -- Analysis of nucleic acid-induced nonimmune cell death in vitro / Simone Romoli and Adriana Migliorini -- In vitro analysis of nucleic acid recognition in B lymphocytes / Saskia Ziegler and Isabelle Bekeredjian-Ding -- Mapping of optimal CD8 T cell epitopes / Julia Roider, Thomas Vollbrecht, and Rika Draenert -- Modular approach to suppression assays : TLR ligands, conditioned medium, and viral infection / Viktor H. Koelzer and David Anz -- MicroRNA methodology : advances in miRNA technologies/ Theresa Kaeuferle ... [et al.] -- Expression profiling by real-time quantitative polymerase chain reaction (RT-qPCR) / Maciej Lech and Hans-Joachim Anders -- Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus / Amanda A. Watkins, Ramon G. B. Bonegio, and Ian R. Rifkin -- Induction and analysis of nephrotoxic serum nephritis in mice / John M. Hoppe and Volker Vielhauer -- Isolation of intratumoral leukocytes of TLR-stimulated tumor-bearing mice / Moritz Rapp, David Anz, and Max Schnurr -- Bifunctional siRNAs for tumor therapy / Fanny Matheis and Robert Besch.
  • 2012 Springer
    Wang, Rong-fu.
    "There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity. Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty. With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers."--Publisher's website.
  • 2008 Springer Protocols
    Ewbank, Jonathan; Vivier, E.
    ENU mutagenesis in mice / Philippe Georgel ... [et al.] -- Innate immunity genes as candidate genes : searching for relevant natural polymorphisms in databases and assessing family-based association of polymorphisms with human diseases / Pascal Rihet -- KIR locus polymorphisms : genotyping and disease association analysis / Maureen P. Martin and Mary Carrington -- Experimental model for the study of the human immune system : production and monitoring of "human immune system" Rag2-/[gamma]c-/- mice / Nicolas Legrand, Kees Weijer, and Hergen Spits -- Bacterial artificial chromosome transgenesis through pronuclear injection of fertilized mouse oocytes / Kristina Vintersten ... [et al.] -- Bioluminescence imaging to evaluate infections and host response in vivo / Pamela Reilly Contag -- Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes / Susanna Celli, Béatrice Breart, and Philippe Bousso -- Dissection of the antiviral NK cell response by MCMV mutants / Stipan Jonjic ... [et al.] -- Analyzing antibody-Fc-receptor interactions / Falk Nimmerjahn and Jeffrey V. Ravetch -- The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture / David Vremec and Ken Shortman -- Analysis of individual natural killer cell responses / Wayne M. Yokoyama and Sungjin Kim -- Isolation and analysis of human natural killer cell subsets / Guido Ferlazzo -- Innate immune function of eosinophils : from antiparasite to antitumor cells / Fanny Legrand ... [et al.] -- Ex vivo and in vitro primary mast cells / Michel Arock ... [et al.] -- Murine macrophages : a technical approach / Luisa Martinez-Pomares and Siamon Gordon -- Clinical analysis of dendritic cell subsets : the dendritogram / Anne Hosmalin, Miriam Lichtner, and Stéphanie Louis -- Clinical analysis of human natural killer cells / Pascale André and Nicolas Anfossi -- Lentiviral transduction of immune cells / Louise Swainson ... [et al.] -- Axenic mouse model / Antoine Giraud -- In vivo analysis of zebrafish innate immunity / Jean-Pierre Levraud ... [et al.] -- Reverse genetics analysis of antiparasitic responses in the malaria vector, Anopheles gambiae / Stephanie A. Blandin and Elena A. Levashina -- Drosophila immunity : methods for monitoring the activity of toll and Imd signaling pathways / Yves Romeo and Bruno Lemaitre -- Investigating the involvement of host factors involved in intracellular pathogen infection by RNAi in Drosophila cells / Hervé Agaisse -- Models of Caenorhabditis elegans infection by bacterial and fungal pathogens / Jennifer R. Powell and Frederick M. Ausubel -- Genetic analysis of Caenorhabditis elegans innate immunity / Michael Shapira and Man-Wah Tan -- Measuring cell-wall-based defenses and their effect on bacterial growth in Arabidopsis / Min Gab Kim and David Mackey.
  • 2013 Karger
    Hartmann, Gunther; Wagner, H.
    Microbiota's influence on immunity / Honda, K. ... [et al.] -- Inflammasomes and mucosal immune response / Elinav, E., Henao-Mejia, J., Flavell, R.A. -- Microbial endocrinology : an evolution-based shared mechanism determining microbiota's influence on health and disease / Lyte, M. -- Standing guard : innate lymphoid cells promote immunity and tissue homeostasis at barrier surface / Monticelli, L.A., Artis, D. -- miRNAs that shape the innate immune system : regulation through toll-like receptor signaling / Curtis, A.M., O'Neill, L.A. -- Type 2 diabetes and islet inflammation / Donath, M.Y. -- The innate immune system in Alzheimer's disease / Becker, H., Halle, A. -- Role of inflammasomes in obesity / Dixit, V.D. -- Gut-brain communication in the regulation of system metabolism / Miller, T.D., Pfliger, P.T., and Tschip, M.H. -- Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in drosophila / Loch, G. ... [et al.] -- Dendritics cells orchestrate innate immunity agains bacterial kidney infection / Tittel, A.P. ... [et al.].
  • 2008 Springer
    Heine, Holger.
    Evolution of resistance genes in plants / Shunyuan Xiao, Wenming Wang, Xiaohua Yang -- The path less explored: innate immune reactions in Cnidarians / Thomas C. G. Bosch -- Bug versus bug : humoral immune responses in Drosophila melanogaster / Deniz Ertürk-Hasdemir ... [et al.] -- Cellular immune responses in Drosophila melanogaster / Adrienne Ivory, Katherine Randle, Louisa Wu -- Immune reactions in the vertebrates' closest relatives, the urochordates / Konstantin Khalturin, Ulrich Kürn, Thomas C. G. Bosch -- Innate immune system of the zebrafish, Danio rerio / Con Sullivan, Carol H. Kim -- Toll-like receptors in the mammalian innate immune system / Andrei E. Medvedev, Stefanie N. Vogel -- NLRs : a cytosolic armory of microbial sensors linked to human diseases / Mathias Chamaillard -- Antimicrobial peptides as first-line effector molecules of the human innate immune system / Regine Gläser, Jürgen Harder, Jens-Michael Schröder -- The complement system in innate immunity / K. R. Mayilyan ... [et al.].
  • 2012 Springer
    Baschieri, Selene.
    Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may
  • 2007 ScienceDirect
    Cheresh, David A.
    Also available: Print – 2007
  • 2014 Springer
    Klink, Magdalena.
    The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
  • 2007 Springer
    Pitha, Paula M.
    Also available: Print – 2007
  • 2005 Springer Protocols
    Carr, Daniel J. J.
    Also available: Print – 2005
  • 2014 Springer
    Fillatreau, Simon; O'Gara, Anne.
    " This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
  • 2014 ScienceDirect
    Yuzhalin, Arseniy E.; Kutikhin, Anton G.
    Introduction : basic concepts -- Interleukin-1 superfamily and cancer -- Interleukin-2 superfamily and cancer -- Interleukin-3, Interleukin-5, and cancer -- IL-6 family and cancer -- Interleukin-10 superfamily and cancer -- Interleukin-12 superfamily and cancer -- Interleukin-17 superfamily and cancer -- The rest of interleukins -- Concluding remarks.
  • 2012 Springer
    Teunissen, Marcel B. M.
    Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies -- Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design -- Delivery systems for intradermal vaccination -- Targeting skin dendritic cells to improve intradermal vaccination -- Intradermal rabies vaccination : the evolution and future of pre- and post-exposure prophylaxis -- Intradermal vaccination to protect against yellow fever and influenza -- The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma -- DNA vaccines and intradermal vaccination by DNA tattooing
  • 2013 Springer
    Cullen, Bryan.
    The APOBEC3 Family of Retroelement Restriction Factors / Eric W. Refsland, Reuben S. Harris -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family / Adam J. Fletcher, Greg J. Towers -- The Antiviral Activities of Tetherin / Stuart J. D. Neil -- Restriction of Retroviral Infection of Macrophages / Mark Sharkey -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors / Welkin E. Johnson -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants / György Szittya, József Burgyán -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates / Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses / Eva Gottwein -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response / Karyn McFadden, Micah A. Luftig.
  • 2012 ScienceDirect
    Daruna, Jorge Hilarion.
    Historical antecedents -- Immune system basics -- Endocrine-immune modulation -- Neuroimmune modulation -- Stress, contextual change, and disease -- Psychosocial stress: neuroendocrine and immune effects -- Infection, allergy, and psychosocial stress -- Cancer, autoimmunity, and psychosocial stress -- Immune activity and psychopathology -- Immune function enhancement -- Integration and implications.
  • 2005 CRCnetBASE
    Blakley, Barry R.; Fournier, Michel; Tryphonas, Helen.
    Also available: Print – 2005
  • 2005 Springer
    Berke, Gideon; Clark, William R.
    Also available: Print – 2005
  • 2003 NCBI Bookshelf
    Carrington, Mary; Norman, Paul.
  • 2005 Springer
    Eichmann, Klaus.
  • 2013 Springer
    Kumar, Awanish.
    Leishmania-related illnesses remain among the world s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
  • 2015 Springer
    Adler, Ben.
    This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world?s most widespread zoonosis. Topics include aspects of human and animal leptospirosis as well as detailed analyses of our current knowledge of leptospiral structure and physiology, epidemiology, pathogenesis, genomics, immunity and vaccines. Updates are presented on leptospiral systematics, identification and diagnostics, as well as practical information on culture of Leptospira. Contact information is also provided for Leptospira reference centers. All chapters were written by experts in the field, providing an invaluable reference source for scientists, veterinarians, clinicians and all others with an interest in leptospirosis.
  • 2012 Springer Protocols
    Ashman, Robert B.
    ENU-based phenotype-driven screening / Vera M. Ripoll, Philip L. Kong, and Paul K. Potter -- Detection and quantification of cytokines and other biomarkers / Evan L. Chiswick ... [et al.] -- Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells / Valérie Barbier ... [et al.] -- Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo / Valérie Barbier ... [et al.] -- Analyzing cell death events in cultured leukocytes / Karin Christenson, Fredrik B. Thorén, and Johan Bylund -- Towards a four-dimensional view of neutrophils / Ben A. Croker, Andrew W. Roberts, and Nicos A. Nicola -- Isolation of human and mouse neutrophils ex vivo and in vitro / Yan Hu -- Measurement of oxidative burst in neutrophils / Yu Chen and Wolfgang G. Junger -- Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates / Brice Korkmaz ... [et al.] -- The macrophage / Chris P. Verschoor, Alicja Puchta, and Dawn M.E. Bowdish -- Generation and characterization of MacGreen mice, the CFS1R-EGFP transgenic mice / R. Tedjo Sasmono and Elizabeth Williams -- Generation of mouse bone marrow-derived macrophages / Silvia Manzanero -- Isolation and differentiation of monocytes-macrophages from human blood / Dipti Vijayan -- In vitro measurement of phagocytosis and killing of Cryptococcus neoformans by macrophages / André Moraes Nicola and Arturo Casadevall -- Measuring the inflammasome / Olaf Gross -- Arginine and macrophage activation / Mònica Comalada -- Immunodetection of granzyme B tissue distribution and cellular localisation / Catherina H. Bird ... [et al.] -- Detection of human and mouse granzyme B activity in cell extracts / Sarah Elizabeth Stewart ... [et al.] -- T cell transfer model of colitis : a great tool to assess the contribution of T cells in chronic intestinal inflammation / Rajaraman Eri, Michael A. McGuckin, and Robert Wadley -- Measurement of nitrite in urine by gas chromatography-mass spectrometry / Dimitrios Tsikas ... [et al.].
  • 2003 Karger
    Elsner, Peter; Markert, Udo R.
    Also available: Print – 2003
  • 2015 Springer
    Pokorski, Mieczyslaw.
    Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.
    Also available: Print – 2015
  • 2011 Springer
    Pambuccian, Stefan E.; Bardales, Ricardo H.
    Introduction -- Overview of ancillary methods in lymph node FNA diagnosis -- Lymphadenopathy: anatomic and clinical clues to fine needle aspiration diagnosis -- Cytology of normal/reactive lymph nodes -- Overall assessment of the aspirate: diagnostic clues -- Overview of the algorithmic pattern-based approach to lymph node FNA -- The polymorphous lymphoid cell pattern -- The monotonous small-cell pattern -- The monotonous intermediate-sized cell pattern -- The monotonous large cell pattern -- The pleomorphic cell pattern -- Infectious and noninfectious lympadenitis -- Unusual neoplastic and nonneoplastic conditions of lymph nodes -- Pitfalls and limitations of FNA of lymph nodes.
  • 2008 Springer
    Tretbar, Lawrence L.
  • 2011 Springer
    Bergan, John J.; Lee, Byung-Boong; Rockson, Stanley G.
    Primary Lymphedema as a Truncular Lymphatic Malformation -- Primary Lymphedema and Klippel-Trénaunay Syndrome -- Special Issues in Pediatric Primary Lymphedema -- Medical Management -- Surgical Management -- Epidemiology -- Etiology and Pathophysiology -- Clinical Overview-Diagnosis and Management -- Genetic Prospects for Lymphedema Management -- Breast Cancer -- Lower Extremity Cancers -- Radiation Complications -- Pathophysiology of Phlebolymphedema and a Physiologic Approach to Chronic Veno-lymphatic Insufficiency' -- Diagnosis and Management of Primary Phlebolymphedema -- Diagnosis and Management of Secondary Phlebolymphedema -- Management of Phlebolymphedema Ulcers -- Lymphedema Management by the Therapists -- Education of the Patient -- Patient/Family Advocacy -- Reimbursement of CDT-based Care -- General Considerations -- Etiology and Classification of Lymphatic Disorders -- Hereditary and Familial Lymphedema -- Embryology of the Lymphatic System and Lymphangiogenesis -- Anatomy of the Lymphatic System and Its Disorders -- Physiology, Pathophysiology, and Lymphodynamics: General Overview -- Lymphedema -- Physiology, Biology, and Lymph Biochemistry -- Physiology - Lymph Flow -- Pathology and Histochemistry -- Clinical Diagnosis: General Overview -- Clinical Staging -- Combined Clinical and Laboratory (Lymphoscintigraphic) Staging -- Early Diagnosis in Latent Phase -- Review of National and International Consensuses on Chronic Lymphedema -- Differential Diagnosis - General Considerations -- Differential Diagnosis - Lipedema -- Laboratory/Imaging Diagnosis: General Guidelines -- Radionuclide Lymphoscintigraphy -- Duplex Ultrasonography -- Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease -- Oil Contrast Lymphangiography -- Fluorescent Microlymphangiography -- Alternative Assessment and Measurement Tools -- Infection -- Physiological Principles of Physiotherapy -- Complete Decongestive Therapy -- Manual Lymph Drainage (Földi Method) -- Manual Lymph Drainage (Leduc Method) -- Compression Therapy -- Intermittent Pneumatic Compression Therapy -- Other Contemporary Treatment Modalities -- Medical Treatment -- Lower Limb Lymphedema -- Upper Limb Lymphedema -- Head and Neck Lymphedema -- Genital Lymphedema -- Psychological Aspect: Compliance and Quality of Life -- General Overview - Historical Background -- General Principles and Indications -- Lymphatic-Venous Derivative and Reconstructive Microsurgery -- Lymphatic-Lymphatic Reconstructive Microsurgery -- Lymph Node-Venous Microvascular Reconstructive Surgery: Filariasis Lymphedema -- Lymph Nodes Transfer Microvascular Reconstructive Surgery -- Current Dilemmas and Controversy -- Prospects for Lymphatic Reconstructive Surgery -- Historical Background - General Overview -- General Principles -- Contemporary Indications and Controversies -- Surgical Treatment of Postmastectomy Lymphedema - Liposuction -- Epilogue.
  • 2015 Springer
    Brorson, Håkan; Greene, Arin K.; Slavin, Sumner A.
    This volume is a clinically-oriented book that can be used for patient care, teaching, or research. It covers the entire field of lymphedema, including both primary and secondary disease, as well as all diagnostic and treatment modalities. The text begins with a foundation for the condition, including its pathophysiology, epidemiology, and morbidity. Next, the classification of lymphedema is covered which is the template for accurate diagnosis. Clinical, radiological, and differential diagnosis of lymphedema is also reviewed. Finally, conservative and operative management is presented, including both physiologic and excisional procedures. Lymphedema: Presentation, Diagnosis, and Treatment provides a comprehensive, easy-to-read reference for any health care provider managing a patient with lymphedema. The text is clinically-focused, evidence-based, and practical. The reader, regardless of his/her level of training or specialty, will be able to adequately treat a patient with lymphedema using this resource. To facilitate its use in clinical settings, the book was designed to be portable. In addition, diagnostic and treatment algorithms are included to further simplify the management of these patients. Patient images are presented throughout the text to illustrate the clinical care of lymphedema. All chapters are written by experts in the field, and contain the most current information on the topic.
  • 2006 Springer
    Badolato, Raffaele; Sozzani, Silvano.
    Also available: Print – 2006
  • 2013 Springer Protocols
    Küppers, Ralf.
    Origin and pathogenesis of B cell lymphomas / Marc Seifert, René Scholtysik, and Ralf Küppers -- Flow cytometry for non-Hodgkin and classical Hodgkin lymphoma / David Wu, Brent L. Wood, and Jonathan R. Fromm -- Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells / Ralf Küppers, Markus Schneider, and Martin-Leo Hansmann -- PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by genescan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics / Elke Boone, Brenda Verhaaf, and Anton W. Langerak -- Expression cloning of human B cell immunoglobulins / Hedda Wardemann and Juliane Kofer -- Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR / Menno C. van Zelm, Magdalena A. Berkowska, and Jacques J.M. van Dongen -- Detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies / Martin J.S. Dyer -- Stereotyped B cell receptors in B cell leukemias and lymphomas / Nikos Darzentas and Kostas Stamatopoulos -- Flow cytometric MRD detection in selected mature B-cell malignancies / Sebastian Böttcher, Matthias Ritgen, and Michael Kneba -- MRD Detection in B-cell non-hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR / Christiane Pott [and others] -- Enrichment of methylated DNA by methyl-CpG immunoprecipitation / Miriam Sonnet [and others] -- Gene expression profile analysis of lymphomas / Katia Basso and Ulf Klein -- FISH and FICTION to detect chromosomal aberrations in lymphomas / Maciej Giefing and Reiner Siebert -- Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens / Vu N. Ngo -- Studying microRNAs in lymphoma / Joost Kluiver, Izabella Slezak-Prochazka, and Anke van den Berg -- Molecular methods of virus detection in lymphoma / Ruth F. Jarrett, Alice Gallagher, and Derek Gatherer -- High-throughput RNA sequencing in B-cell lymphomas / Wenming Xiao [and others].
  • 2014 CRCnetBASE
    Howard, Gary C.; Kaser, Matthew R.
    "This second edition provides guidance on all aspects of how to make and use antibodies for research, and commercial and industrial applications. All chapters are revised, updated, or expanded. New material in the book includes western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present descriptions of basic methods for making and using antibodies and describe basic laboratory techniques in detail. Each chapter includes introductory material, allowing for a better understanding of each concept. Practical examples are also included"--Provided by publisher.
  • 2002 Karger
    Perlmann, Peter; Troye-Blomberg, Marita.
    pt. 1. Malaria parasites and disease -- Structure and life cycle / H. Fujioka -- Malaria parasites and the Anopheles mosquito /G. Dimopoulos -- Malaria: pathogenicity and disease / M. English -- pt. 2. Malaria antigens -- Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein / P. Sinnis -- Immune responses to liver-stage parasites: implications for vaccine development / M.R. Hollingdale -- Merozoite antigens involved in invasion / K. Berzins -- Asexual blood stages of malaria antigens: cytoadherence / D.I. Baruch -- Rosetting and autoagglutination in Plasmodium falciparum / V. Fernandez -- Sexual and sporogonic stage antigens / R.W. Sauerwein -- pt. 3. Malaria infection: immunity and regulation -- Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology / J. Langhorne -- Malaria and the immune system in humans / P. Perlmann -- Genetic regulation of malaria infection in humans / M. Troye-Blomberg -- pt. 4. Malaria vaccines -- Pre-erythrocytic malaria vaccines to prevent Plasmodium flaciparum malaria / W.R. Ballou -- Vaccines against asexual stage malaria parasites / S. Kumar -- Transmission-blocking vaccines / D.C. Kaslow -- Nucleic acid vaccines against malaria / D.L. Doolan -- Antidisease vaccines / L. Schofield -- Adjuvants and malaria vaccine development / L. Xiao -- Malaria vaccine trials / B. Greenwood.
    Also available: Print – 2002
  • 2007 CRCnetBASE
    Hoffmann-Sommergruber, Karin; Mills, E. N. Clare; Wichers, Harry.
    pt. 1. What are food allergens and allergies? -- pt. 2. Allergens in foods - from raw to processed foods -- pt. 3. Assessing allergic risks and practical management of allergens in food.
  • 2002 Ovid
    Adelman, Daniel C.; Casale, Thomas B.; Corren, Jonathan.
    Also available: Print – 2002
  • 2012
    Adelman, Daniel C.; Casale, Thomas B.; Corren, Jonathan.
    Status: Not Checked OutLane Catalog Record
    Introduction to the immune system / Lori Broderick, Taylor A. Doherty, and David Broide -- Immediate hypersensitivity : approach to diagnosis / Sarbjit S. Saini and Nkiruka Erekosima -- Aeroallergens and environmental factors / William Neaville, Robert Ausdenmoore, and Robert K. Bush -- Rhinitis / Candace Bouler Anz and Mark S. Dykewicz -- Sinusitis, nasal polyps, and otitis media / Ricardo A. Tan and Jonathan Corren -- Immunotherapy for inhalant allergens / Harold S. Nelson -- Allergic and immunologic disorders of the eye / Leonard Bielory -- Asthma diagnosis / Stephen C. Lazarus -- Asthma treatment / Joel M. Hartman ... [et al.] -- Immunologic diseases of the lung / Shefalee Amin, Michelle Zeidler, and Eric Kleerup -- Atopic dermatitis and contact dermatitis / Mark Boguniewicz, Marcella Aquino, and Luz Fonacier -- Urticaria and angioedema / Jeffrey R. Stokes and Mark H. Moss -- Anaphylaxis / Phil Lieberman and Debendra Pattanaik -- Insect allergy / David B. K. Golden -- Drug allergy / David A. Khan -- Allergic and non-allergic reactions to food / Stephen R. Boden and A. Wesley Burks -- Eosinophilic gastrointestinal disorders / Terri F. Brown-Whitehorn ... [et al.] -- Primary immunodeficiency diseases / Shradha Agarwal and Charlotte Cunningham-Rundles -- Approach to the patient with recurrent infections / Zuhair K. Ballas -- Diagnostic immunology / Thomas A. Fleisher, Joao Bosco Oliveira, and Jack J. H. Bleesing -- Adverse responses to vaccines / John M. Kelso -- Complementary medicine in allergy and immunology / Timothy Ryan Mainardi and Leonard Bielory -- Building related illness / Jessica Savage and Robert A. Wood.
  • 2006 Springer
    Plotkin, Stanley A.
    Mass Vaccination: When and Why / D. L. Heymann and R. B. Aylward -- Mass Vaccination and Surveillance/Containment in the Eradication of Smallpox / J. M. Lane -- Mass Immunization Programs: Principles and Standards / J. D. Grabenstein and R. L. Nevin -- Immunization Campaigns in the UK / K. Noakes and D. Salisbury -- Diphtheria / C. R. Vitek -- Universal Mass Vaccination against Hepatitis A / F. E. André -- Mass Vaccination against Hepatitis B: the French Example / F. Denis and D. Levy-Bruhl -- Mass Vaccination for Annual and Pandemic Influenza / B. Schwartz and P. Wortley -- Is Global Measles Eradication Feasible? / C. A. de Quadros -- Measles Aerosol Vaccination / J. L. Valdespino-Gómez, M de Lourdes Garcia-Garcia, J. Fernandez-de-Castro, A. M. Henao-Restrepo, J. Bennett, and J. Sepulveda-Amor -- Mass Vaccination Campaigns for Polio Eradication: an Essential Strategy for Success / R. W. Sutter and C. Maher -- Rubella Mass Campaigns / S. Reef -- Mass Vaccination to Control Epidemic and Endemic Typhoid Fever / M. M. Levine -- Mass Vaccination: Solutions in the Skin / G. M. Glenn and R. T. Kenney.
    Also available: Print – 2006
  • 2011 Springer
    Ribatti, Domenico; Crivellato, Enrico.
    Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
  • 2005 Karger
    Also available: Print – 2005
  • 2011 Springer
    Lythe, Grant; Molina-París, Carmen.
    Preface -- Thymocyte development -- A review of mathematical models for T cell receptor triggering and antigen discrimination -- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation -- T cell activation and function: role of signal strength -- The cyton model for lymphocyte proliferation and differentiation -- Modeling itravital two-photon data of lymphocyte migration and interaction -- Modeling lymphocyte dynamics in vivo -- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery -- Multivariate competition processes: a model for two competing T cell clonotypes -- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation -- Dendritic cell migration in the intestinal tract -- Reassessing germinal center reaction concepts -- B cell strategies of Ag recognition in a stratified immune system -- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells -- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells -- A Physicist{u2019}s approach to immunology -- Timescales of the adaptive immune response -- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection -- Viral immunity and persistence -- Index.
  • 2009 Springer
    Griffin, Diane E.; Oldstone, Michael B. A.
    Making it to the synapse : measles virus spread in and among neurons / V.A. Young and G.F. Rall -- Modeling subacute sclerosing panencephalitis in a transgenic mouse system : uncoding pathogenesis of disease and illuminating components of immune control / M.B.A. Oldstone -- Measles studies in the macaque model / R.L. de Swart -- Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines / P. Pillet, N. Svitek and V. von Messling -- Current animal models : cotton rat animal model / S. Niewiesk -- Current animal models : transgenic animal models for the study of measles pathogenesis / C.I. Sellin and B. Horvat -- Molecular epidemiology of measles virus / P.A. Rota, D.A. Featherstone, and W.J. Bellini -- Human immunology of measles virus infections / D. Naniche -- Measles control and the prospect of eradication / W.J. Moss -- Measles : old vaccines, new vaccines / D.E. Griffin and C.-H. Pan -- Measles virus for cancer therapy / S.J. Russell and K.W. Peng -- Measles virus-induced immunosuppression / S. Schneider-Schaulies and J. Schneider-Schaulies -- Hostile communication of measles virus with host innate immunity and dendritic cells / B. Hahm.
    Also available: Print – 2009
  • 2005 ScienceDirect
    Lotze, Michael T.; Thomson, Angus W.
    MHC class I -- MHC class II -- Cytokine receptor heterogeneity -- Genetic diversity at human cytokine loci in health and disease -- Signaling molecules affecting immune response -- Toll-like receptors in innate immunity -- DNA sequence-specific transcription factors -- Genetic diversity in NK and NKT cells -- Handling sera and obtaining fluid from different compartments -- Acute-phase proteins and inflammation -- Complement in health and disease -- Immunoglobulin titers and immunoglobulin subtypes -- Human antiglobulin responses -- Rheumatoid factors -- Autoantibodies -- Antibody affinity using fluorescence -- SLE-associated tests -- Multiplexed serum assays -- Handling and storage of cells and sera: practical considerations -- Phenotypic and functional measurements on circulating immune cells and their subsets -- Natural killer cells -- Tetramer analysis -- Peripheral blood naive and memory B cells -- Dendritic cells -- Monocytes and macrophages -- Tumor cells -- Regulatory T cells -- Intracellular cytokine assays -- Cytolytic assays -- Mixed leukocyte reactions -- Antigen/mitogen-stimulated lymphocyte proliferation -- Monitoring cell death -- Cytokine enzyme linked immunosorbent spot (ELISPOT) assay -- Testing natural killer cells -- Delayed type hypersensitivity responses -- Rebuck windows: granulocyte function -- The vascular and coagulation systems -- Sentinel node assays -- Imaging inflammation -- Cancer - solid tumors -- Cancer - hematologic disorders -- Autoimmunity - rheumatoid arthritis -- Autoimmunity - type 1 diabetes -- Autoimmunity - systemic lupus erythematosus -- Autoimmunity - multiple sclerosis -- Autoimmunity - inflammatory bowel disease -- Autoimmunity - endocrine -- Autoimmunity - vasculitis -- Transplantation -- Viral responses - HIV-1 -- Viral responses - epstein-barr virus -- Viral responses - hepatitis -- Dermatology -- Arteriosclerosis -- Primary immunodeficiencies -- Asthma and allergy -- Serum proteomic profiling and analysis -- Imaging cytometry -- Cancer biometrics -- Genomics and microarrays -- Image informatics.
  • 2005 Karger
    Kabelitz, Dieter; Schröder, Jens-Michael.
    Also available: Print – 2005
  • 2005 Springer
    Gupta, Sudhir; Paul, William E.; Steinman, Ralph M.
    Also available: Print – 2005
  • 2007 Springer
    Ahmed, Rafi; Gupta, Sudhir; Sher, Alan.
    Also available: Print – 2007
  • 2001 CRCnetBASE
    Virella, Gabriel.
    Also available: Print – 2001
  • 2014 Springer
    Meunier, Yann A.
    This book outlines risk assessments for 28 diseases and medical conditions including the following aspects: genetics, biochemistry, serology, past medical history, family history, co-morbidities, age, gender, ethnicity, nutrition and lifestyle. Recommendations are made for how to avoid, eliminate or mitigate risks. Preventing measures concerning chemical compound intake, lifestyle and nutrition are proposed. The unique content and approach of the book to chronic disease management make it a state-of-the-art reference work, addressing a missing component of medical care and reflecting the cutting edge of preventive medicine.
  • 2012 CRCnetBASE
    Watson, Ronald R.
    "This new edition presents information on how melatonin is synthesized and produced in the body as well as how this hormone affects several diseases. The book heavily focuses on prevention as well as treatment of various human disease states including behavior disorders, mental disorders, breast cancer, bone health, and gastrointestinal diseases. It covers the role of melatonin in the prevention of oxidative stress, mutagenesis, sun damage, ocular health, gut motility, and detoxification. It also presents mechanisms of melatonin action in humans including cell modulation, signaling mechanisms, protective effects, and melatonin receptors as well as its role as an antioxidant"--Provided by publisher.
  • 2010 Springer
    Schoenberger, Stephen P.; Zanetti, M.
    Memory TH1/TH2 cell generation controlled by Schnurri-2 / Toshinori Nakayama and Motoko Y. Kimura -- Transcriptional regulation during CD8 T-cell immune responses / Ivana Munitic ... [et al.] -- The role of interleukin-2 in memory CD8 cell differentiation / Onur Boyman, Jae-Ho Cho and Jonathan Sprent -- The role of inflammation in the generation and maintenance of memory T cells / Noah S. Butler and John T. Harty -- The role of OX40 (CD134) in T-cell memory generation / Andrew D. Weinberg -- The role of precursor frequency in the differentiation of memory T cells : memory by numbers / Amanda L. Marzo, Ryan T. Sowell and Bernadette Scott -- CD8 T-cell memory differentiation during acute and chronic viral infections / Vandana Kalia, Surojit Sarkar and Rafi Ahmed -- Longevity of T-cell memory following acute viral infection / Joshua M. Walker and Mark K. Slifka -- Principles of memory CD8 T-cells generation in relation to protective immunity / Maurizio Zanetti, Paola Castiglioni and Elizabeth Ingulli -- Memory T cells in rhesus macaques / Monica Vaccari and Genoveffa Franchini -- Memory T-cell subsets in parasitic infections / Sara Colpitts and Phillip Scott -- Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responses / Kory L. Alderson and William J. Murphy -- Memory T-cell responses and survival in human cancer : remember to stay alive / Matthieu Camus and Jérôme Galon -- Analysis of vaccine-induced T cells in humans with cancer / Stefanie L. Slezak ... [et al.] -- Memory T-cell homeostasis and senescence during aging / Sian M. Henson and Arne N. Akbar.
    Also available: Print – 2010
  • 2001 CRCnetBASE
    Fernandez-Botran, Rafael; Větvička, Václav.
  • 2010 ClinicalKey
    Aronson, J. K.; Meyler, L.
    Drugs Used in Cancer Chemotherpy -- Corticosteroids and Prostaglandins -- Cytokines and Cytokine Modulators Interferons -- Monoclonal Antibodies -- Immune Modulators.
  • 2013 Springer
    Aptsiauri, Natalia; Cabrera, Teresa; Garcia-Lora, Angel Miguel.
    Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • 2008 Springer
    Bosio, Andreas; Gerstmayer, Bernhard.
    Also available: Print – 2008
  • 2009 Karger
    Brandtzaeg, Per; Isolauri, Erika; Prescott, Susan L.
    A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- "ABC" of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. ... [et al.] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. ... [et al.] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. ... [et al.] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A.
  • 2015 Springer
    Greene, Catherine M.
    The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohnℓ́ℓs disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
    Also available: Print – 2015
  • 2010 Springer Protocols
    Monticelli, Silvia.
    A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation -- Normalization of microRNA quantitative RT-PCR data in reduced scale experimental designs -- MicroRNA detection in bone marrow cells by LNA-FISH -- Measuring microRNA expression in size-limited facs-sorted and microdissected samples -- MicroRNA cloning from cells of the immune system -- High-throughput profiling in the hematopoietic system -- Construction of small RNA cDNA libraries for deep sequencing -- MicroRNA-profiling in formalin-fixed paraffin-embedded specimens -- Expression of miRNAs in lymphocytes : A review -- Mouse models for miRNA expression: The ROSA26 locus -- Regulation of monocytopoiesis by microRNAs -- MicroRNA activity in B lymphocytes -- Isolation and characterization of microRNAs of human mature erythrocytes -- Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors -- Monitoring microRNA activity and validating microRNA targets by reporter-based approaches -- Lentivirus-mediated antagomir expression -- Solution structure of miRNA:mRNA complex -- MiRNA editing -- Computational prediction of microRNA targets -- Large-scale integration of microRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems -- Identification and validation of the cellular targets of virus-encoded microRNAs.
  • v. 1-2., 2009
    Adkinson, N. Franklin; Middleton, Elliott.
    Status: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    Adkinson, N. Franklin; Middleton, Elliott.
  • 2017 ClinicalKey
    O'Hehir, Robyn E.; Holgate, S. T.; Sheikh, Aziz.
    Introduction to mechanisms of allergic diseases -- The origins of allergic disease -- Epidemiology of allergic diseases -- Indoor and outdoor allergens and pollutants -- Principles of allergy diagnosis -- Allergen-specific immunotherapy -- Asthma -- Allergic rhinitis and conjunctivitis -- Drug allergy -- Urticaria and angioedema without wheals -- Atopic dermatitis and allergic contact dermatitis -- Food allergy and gastrointestinal syndromes -- Anaphylaxis -- Occupational allergy -- Insect allergy.
  • 2005 Springer
    Grosschedl, Rudolf; Singh, H.
    Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation / K.L. Medina, H. Singh -- Helix-loop-helix proteins in lymphocyte lineage determination / B.L. Kee -- Ikaros-family proteins : in search of molecular functions during lymphocyte development / B.S. Cobb, S.T. Smale -- Biochemistry of V(D)J recombination / D.G. Schatz, E. Spanopoulou -- The pre-B cell receptor in B cell development : recent advances, persistent questions and conserved mechanisms / M.R. Clark ... [et al.] -- Transcriptional control of B cell activation / L.M. Corcoran -- Expression of MHC II genes / G. Drozina ... [et al.] -- Class switch recombination : an emerging mechanism / A.L. Kenter -- Blimp-1 ; Immunoglobulin secretion and the switch to plasma cells / R. Schiammas, M.M. Davis -- Wnt signaling in lymphopoiesis / A. Timm, R. Grosschedl.
    Also available: Print – 2005
  • 2014 Springer
    Nimmerjahn, Falk.
    This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • 2005 Springer
    Zouali, Moncef.
    Also available: Print – 2005
  • 2011 Springer
    Wu, Albert M.
    Part 1. Introduction to Glyco-Experiences -- Serendipity in Scientific Discoveries: Some Examples in Glycosciences / Yuan-Chuan Lee -- My 30-Year Devotion to the N-Linked Oligosaccharide Structures / Noriko Takahashi -- Part 2. Blood Group ABH/Le-related Antigens -- Human Blood Group ABH/Ii, Lea,b,x,y, and Sialyl Lea,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions / Hui-Li Chen -- A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes / Su-Chen Li, Kimberly M. Anderson and Yu-Teh Li -- Part 3. Lectins -- Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin-Glycan Interactions / Albert M. Wu, Jia-Haw Liu, Tanuja Singh and Zhangung Yang -- Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes / Albert M. Wu, Tanuja Singh, Jia-Hau Liu, Sabine André and Martin Lensch, et al. -- Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens / Pierre Rougé, Willy J. Peumans, Els J. M. Van Damme, Annick Barre and Tanuja Singh, et al. -- The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins / Nechama Gilboa-Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Batya Lerrer and Anne Imberty, et al. -- On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder -- Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose, and Ethanol / Nachman C. Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Itschak Axelrad and Nechama Gilboa-Garber -- Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins / Jared Q. Gerlach, Michelle Kilcoyne, Seron Eaton, Veer Bhavanandan and Lokesh Joshi -- Novel Concepts About the Role of Lectins in the Plant Cell / Els J. M. Van Dammes, Elke Fouquaert, Nausicaä Lannoo, Gianni Vandenborre and Dieter Schouppe, et al. -- Part 4. Structures and Functions of Glycolipids -- Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization / Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani and Manuela Valsecchi, et al. -- 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells / Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal and Sarmila Chandra, et al. -- GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells / Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang and Toshinori Sato, et al. -- Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies / Robert K. Yu, Toshio Ariga, Seigo Usuki and Ken-ichi Kaida -- Structure and Function of Glycolipids in Thermophilic Bacteria / Feng-Ling Yang, Yu-Liang Yang and Shih-Hsiung Wu -- Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai -- Part 5. Structures and Functions of Complex Carbohydrates -- Roles for N- and O-Glycans in Early Mouse Development / Suzannah A. Williams and Pamela Stanley -- Glycobiology in the Field of Gerontology (Glycogerontology) / Akira Kobata -- Galectins in Regulation of Apoptosis / Fu-Tong Liu, Ri-Yao Yang, Jun Saegusa, Huan-Yuan Chen and Daniel K. Hsu -- Avian and Human Influenza Virus Receptors and Their Distribution / Yasuo Suzuki -- Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis / Dipak K. Banerjee, Caroline M. Oliveira, José J. Tavárez, Viswa N. Katiyar and Subiman Saha, et al. -- Mucin O-Glycan Branching Enzymes: Structure, Function, and Gene Regulation / Pi-Wan Cheng and Prakash Radhakrishnan -- Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza -- Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis / Pierre Rougé, Wim Nerinckx, Clare Gough, Jean-Jacques Bono and Annick Barre -- Part 6. Glycoimmunology -- O-Acetylated Sialic Acids and Their Role in Immune Defense / Roland Schauer, G. Vinayaga Srinivasan, Dirk Wipfler, Bernhard Kniep and Reinhard Schwartz-Albiez -- Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes / Reiji Kannagi, Katsuyuki Ohmori, Guo-Yun Chen, Keiko Miyazaki and Mineko Izawa, et al. -- Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum / Elwira Lisowska and Maria Duk -- Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation / Pei-Weng Wang and Tai-Long Pan -- Part 7. Glycobiology of Cancer -- Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos and Susan N. Thomas -- Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l-PPMP and Cisplatin / Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks and James R. Johnson, et al. -- Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor-Host Interactions / Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli and Valentina Nocco, et al. -- Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance / Sadako Inoue, Ken Kitajima, Chihiro Sato and Shinji Go -- Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zou and Harold J. Jennings -- Part 8. Glyco Applications -- Synthesis of Hemagglutinin-Binding Trisaccharides / Cheng-Chung Wang, Suvarn S. Kulkarni, Medel Manuel L. Zulueta and Shang-Cheng Hung -- Fabrication and Applications of Glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak and Chun-Cheng Lin -- Glycan Arrays to Decipher the Specificity of Plant Lectins / Els J. M. Van Damme, David F. Smith, Richard Cummings and Willy J. Peumans -- Targeting C-Type Lectin for the Treatment of Flavivirus Infections / Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu and Shie-Liang Hsieh.
    Also available: Print – 2011
  • 2014 Springer
    Hilbi, Hubert.
    Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • 2009 Springer
    Sasakawa, Chihiro.
    Functional morphology of the gastrointestinal tract / L. Shen -- Vibrio cholerae interactions with the gastrointestinal tract: Lessons from animal studies / J.M. Ritchie and M.K. Waldor -- Interaction of Yersinia with the gut: Mechanisms of pathogenesis and immune evasion / P. Dube -- Molecular mechanisms of Salmonella virulence and host resistance / Y. Valdez, R.B.R. Ferreira and B.B. Finlay -- Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori / tW. Fischer, S. Prassl and R. Haas -- Listeria as an enteroinvasive gastrointestinal pathogen / S.B. Barbuddhe and T. Chakraborty -- Molecular mechanisms of Campylobacter infection / J.P.M. Putten ... [et al.] -- Shigella infection of intestinal epithelium and circumvention of the host innate defense system / H. Ashida ... [et al.].
    Also available: Print – 2009
  • 2010
    Jones, Jonathan Wiley; Amieva, M. R.; Falkow, Stanley; Monack, Denise M.; Nelson, W. J.; Schneider, David.
    Francisella tularensis is a facultative intracellular pathogen that causes the disease tularemia. The ability of F. tularensis to escape phagosomal degradation and replicate in the macrophage cytosol is central to its pathogenesis. The macrophage responds to the presence of cytosolic F. tularensis with the production of type-I interferons (IFN) and subsequent activation of the inflammasome. We conducted a forward genetic screen of a F. novicida transposon library to identify mutants that resulted in an increased or decreased cytosolic response in macrophages. We identified 164 F. novicida mutants that lead to increased type-I IFN production and inflammasome activation in macrophages. We also identified 74 mutants that resulted in decreased type-I IFN and inflammasome responses in macrophages. Finally, we identified AIM2 as the host receptor responsible for inflammasome activation in response to cytosolic F. novicida. We showed that lysing cytosolic F. novicida leads to release of bacterial DNA that triggers type-IFN through a pathway involving the adaptor STING. STING-dependent type-I IFN production increases the expression of AIM2, which complexes with the bacterial DNA and initiates inflammasome activation. We further demonstrate that AIM2 is critical for innate immunity to F. novicida infection in vivo. Thus we identified a novel bacterial ligand and novel cytosolic sensing components that play a role in the host defense to bacterial infections.
  • 2005 Springer
    Oldstone, Michael B. A.
    Molecular mimicry, microbial infection, and autoimmune disease : evolution of the concept / M.B.A. Oldstone -- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination / K.W. Wucherpfennig -- A virus-induced molecular mimicry model of multiple sclerosis / J.K. Olson, A.M. Ercolini, and S.D. Miller -- Suppression of autoimmunity via microbial mimics of altered peptide ligands / L. Steinman, P.J. Utz, and W.H. Robinson -- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry / M.B.A. Oldstone -- Trypanosoma cruzi-induced molecular mimicry and Chagas' disease / N. Gironès, H. Cuervo, and M. Fresno -- HTLV-1 induced molecular mimicry in neurological disease / S.M. Lee ... [et al.] -- Molecular mimicry : anti-DNA antibodies bind microbial and nonnucleic acid self-antigens / J.S. Rice ... [et al.] -- Chlamydia and antigenic mimicry / K. Bachmaier and J.M. Penninger.
    Also available: Print – 2005
  • 2010
    Parameswaran, Poornima; Fire, Andrew Z.; Glenn, Jeffrey S.; Kay, Mark A.; Kirkegaard, Karla; Singh, Upinder.
    Small RNAs that are 19-30 nucleotides in length use the genetic information encoded in their sequence to effect gene regulation in a sequence-directed manner. Infections with RNA viruses in plants, worms and flies generate short viral-derived RNAs ("vsRNAs") that map to the genome of the infecting virus. The regulated production of these vsRNAs and their engagement by the immune apparatus is essential for inhibiting viral growth, making vsRNAs important components of antiviral immunity in these organisms. RNA virus-derived vsRNA-mediated gene silencing is yet to be demonstrated in mammalian systems. We investigated diverse RNA virus-mammalian systems, and characterized changes in small RNA populations that occur during viral infection in animal cells using high-throughput sequencing. Due to the large number of samples to be analyzed, we designed DNA barcodes to 'tag' RNA samples from individual experiments, which facilitated sequencing in parallel from multiple samples. Our work demonstrated the generality of RNA virus-derived vsRNA production, and the ability of the cellular short RNA apparatus to engage these vsRNAs in worms during Flock House Virus replication, and in mammalian cells during infections with Hepatitis C, Polio, Dengue, Vesicular Stomatitis or West Nile virus. In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host-encoded small RNA (miRNA) profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We found evidence for populations of vsRNAs that exist as duplexed small interfering RNAs ("siRNAs; " effectors of gene silencing) with zero to three nucleotide 3' overhangs. We also observed strand-selective loading of siRNAs onto Argonaute complexes, which are mediators of gene silencing. We quantitated the capacity of these HCVrep-derived vsRNAs to down-regulate target mRNAs in a sequence-specific manner in mammalian systems. We found that abundant HCVrep vsRNAs are not capable of mediating robust silencing (i.e. 2-fold or higher) of Luciferase reporters that have been engineered with vsRNA targets. Additionally, over-expression of siRNAs corresponding to five abundant vsRNAs failed to enhance silencing of Hepatitis C Virus mRNA. These results complement each other and suggest that in mammalian hosts, the virus may coexist with an abundant population of vsRNAs. Questions still remain as to whether robust gene silencing may be achieved by the cooperative action of abundant vsRNAs, or if abundant vsRNAs specifically inhibited from functioning in gene silencing, or alternatively, if they have novel roles in pathways distinct from gene silencing.
  • 2013 Springer
    Giese, Matthias.
    This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.
  • 2014 Springer
    Giese, Matthias.
    This title discusses all aspects of non-infectious and non-cancer -- so called NINC -- vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. Practical perspectives of patentability of vaccines are discussed. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.
  • 2013 Future Med
    Uckun, Fatih M.
    Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • 2014 Springer Protocols
    Fischer, Nicolas; Ossipow, Vincent.
    Antigen production for monoclonal antibody generation / Giovanni Magistrelli and Pauline Malinge -- Method for the generation of antibodies specific for site and posttranslational modifications / Hidemasa Goto and Masaki Inagaki -- Immunization, hybridoma generation, and selection for monoclonal antibody production / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Hybridoma technology for the generation of rodent mAbs via classical fusion / Efthalia Chronopoulou [and three others] -- Generation of rabbit monoclonal antibodies / Pi-Chen Yam and Katherine L. Knight -- Screening hybridomas for cell surface antigens by high-throughput homogeneous assay and flow cytometry / Alejandro Uribe-Benninghoff [and four others] -- Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker / Suba Dharshanan and Cheah Swee Hung -- Design and generation of synthetic antibody libraries for phage display / Gang Chen and Sachdev S. Sidhu -- Selection and screening using antibody phage display libraries / Patrick Koenig and Germaine Fuh -- Yeast surface display for antibody isolation : library construction, library screening, and affinity maturation / James A.Van Deventer and Karl Dane Wittrup -- Human B cell immortalization for monoclonal antibody production / Joyce Hui-Yuen, Siva Koganti, and Sumita Bhaduri-McIntosh -- Using next-generation sequencing for discovery of high- frequency monoclonal antibodies in the variable gene repertoires from immunized mice / Ulrike Haessler and Sai T. Reddy -- Cloning, reformatting, and small-scale expression of monoclonal antibody isolated from mouse, rat, or hamster hybridoma / Jeremy Loyau and François Rousseau -- Cloning of recombinant monoclonal antibodies from hybridomas in a single mammalian expression plasmid / Nicole Müller-Sienerth [and three others] -- Monoclonal antibody purification by ceramic hydroxyapatite chromatography / Larry J. Cummings, Russell G. Frost, and Mark A. Snyder -- Rapid purification of monoclonal antibodies using magnetic microspheres / Pauline Malinge and Giovanni Magistrelli -- Generation of cell lines for monoclonal antibody production / Krista Alvin and Jianxin Ye -- Expression and purification of recombinant antibody formats and antibody fusion proteins / Martin Siegemund [and four others] -- Purification of antibodies and antibody fragments using CaptureSelect [trademark] affinity resins / Pim Hermans, Hendrik Adams, and Frank Detmers -- Reformatting of scFv antibodies into the scFv-Fc format and their downstream purification / Emil Bujak [and three others] -- Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT® / Eltaf Alamyar [and three others] -- Measuring antibody affinities as well as the active concentration of antigens present on a cell surface / Palaniswami Rathanaswami -- Determination of antibody structures / Robyn L. Stanfield -- Affinity maturation of monoclonal antibodies by multi-site- directed mutagenesis / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Epitope mapping with membrane-bound synthetic overlapping peptides / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping by epitope excision, hydrogen/deuterium exchange, and peptide-panning techniques combined with in silico analysis/ Nicola Clementi [and five others] -- Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen / Gertrudis Rojas -- Epitope mapping with random phage display library / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping of monoclonal and polyclonal antibodies using bacterial cell surface display / Anna-Luisa Volk, Francis Jingxin Hu, and Johan Rockberg -- Ion exchange-high-performance liquid chromatography (IEX-HPLC) / Marie Corbier, Delphine Schrag, and Sylvain Raimondi -- Size exclusion-high-performance liquid chromatography (SEC-HPLC) / Delphine Schrag, Marie Corbier, and Sylvain Raimondi -- N-glycosylation characterization by liquid chromatography with mass spectrometry / Song Klapoetke -- Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization / Stefanie Derer [and six others] -- Labeling and use of monoclonal antibodies in immunofluorescence : protocols for cytoskeletal and nuclear antigens / Christoph R. Bauer -- Generation and use of antibody fragments for structural studies of proteins refractory to crystallization / Stephen J. Stahl, Norman R. Watts, and Paul T. Wingfield -- Antibody array generation and use / Carl A.K. Borrebaeck and Christer Wingren.
  • 2007. Springer Protocols
    Albitar, Maher.
  • 2014 Wellcome Trust
    Jones, Emma M.; Tansey, E. M.
  • 2013 Springer Protocols
    Allen, Irving C.
    Transgenic Mouse Models -- Pulmonary Antigen Presenting Cells: Isolation, Purification, and Culture -- Evaluation of T Cell Function in Allergic Disease -- Evaluating B-Cells: From Bone Marrow Precursors to Antibody Producing Cells -- Protocols for Identifying, Enumerating and Assessing Mouse Eosinophils -- Evaluation of Classical, Alternative, and Regulatory Functions of Bone Marrow-Derived Macrophages -- Applications of Mouse Airway Epithelial Cell Culture for Asthma Research -- Isolation and Characterization of Mast Cells in Mouse Models of Allergic Diseases -- Purifying and Measuring Immunoglobulin E (IgE) and Anti-IgE -- Protocols for the Induction and Evaluation of Systemic Anaphylaxis in Mice -- Contact Hypersensitivity Models in Mice -- Induction of Allergic Rhinitis in Mice -- Induction of Allergic Airway Disease Using House Dust Mite Allergen -- An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airways Disease -- PAMPs and DAMPs in Allergy Exacerbation Models -- Assessment of Airway Hyperresponsiveness in Mouse Models of Allergic Lung Disease Using Detailed Measurements of Respiratory Mechanics -- Bilateral Vagotomy as a Tool for Determining Autonomic Involvement in Airway Responses in Mouse Models of Asthma -- Clara Epithelial Cell Depletion in the Lung -- A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma -- Assessment of Airway Hyperresponsiveness in Murine Tracheal Rings -- Use of the Cockroach Antigen Model of Acute Asthma to Determine the Immunomodulatory Role of Early Exposure to Gastrointestinal Infection -- Expression Profiling to Identify Candidate Genes Associated with Allergic Phenotypes -- Flow Cytometric Methods for the Assessment of Allergic Disease -- Generation of Bone Marrow and Fetal Liver Chimeric Mice.
  • 2013 Springer Protocols
    Allen, Irving C.
    The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
  • 2007 Springer
    Kaetzel, Charlotte Slayton.
  • 2006 Springer
    Tyring, Stephen K.
    The role of mucosal immunity in protection against viral diseases / Vandana Madkan, Karan Sra, and Stephen K. Tyring -- Anogenital mucosal immunology and virology / Anthony Simmons -- Gastrointestinal mucosal immunology / David A. Bland, Carlos A. Barrera, and Victor E. Reyes -- Virology of the gastrointestinal tract / Richard L. Ward ... [et al.] -- Oral manifestations of viral diseases / Denis P. Lynch -- Common respiratory viruses and pulmonary mucosal immunology / David B. Huang -- Ophthalmic manifestations of viral diseases / Steven Yeh and Mitchell P. Weikert.
  • 2013 Springer
    Prince, Alice.
    In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • 2005 ScienceDirect
    Lamm, Michael E.; McGhee, Jerry R.; Mestecky, Jiri.
    Also available: Print – v. 1-2, 2005.
  • 2012 Springer
    Kozlowski, Pamela A.
    Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
  • 2012 Springer
    Gao, Zhong-Shan.
    Part I. General Allergy. Prevalence of Allergic Diseases in China / Huan Qian, Min Zheng -- Mechanism of Type I Hypersensitivity / Cheng Zhou -- Multidisciplinary Approaches to Allergy Prevention / Luud J.W.J. Gilissen, Zhong-Shan Gao, Zhi Chen -- Part II. Allergenic Sources and Allergens. Overview of Allergen Sources in China / Zhao-Wei Yang, Zhong-Shan Gao, Ying-Tao Ma [and others] -- Allergen Protein Families and Cross-Reactivity / Luud J.W.J. Gilissen, Zhong-Shan Gao -- Seafood Allergens in China and Anti-allergenic Property of Seaweeds / Zhen-Xing Li, Hong Lin -- Food Allergen Epitopes / Hong-Bing Chen, Jin-Yan Gao -- Recombinant Allergens and Applications / Ying-Tao Ma, Zhao-Wei Yang, Zhong-Shan Gao -- Part III. Diagnosis. The CREATE Project: Development of Certified Reference Materials for Allergenic Products and Validation of Methods for Their Quantification / R. van Ree, M.D. Chapman, F. Ferreira [and others] -- Diagnosis of Skin Allergy Diseases / Huan Qian, Min Zheng -- Novel Approaches for the In-Vitro Diagnosis of Type I Allergies / Margrit Fooke -- Influence of Food Processing, Digestion and the Food Matrix on Allergenicity & Cellular Measures of Allergenicity / Y.M. Vissers, H.J. Wichers, H.F.J. Savelkoul -- Part IV. Therapies and Pharmacy. Immunotherapy of Asthma: From Basic Research to Clinical Practices / Hui-Ying Wang, Hua-Hao Shen -- Pharmacotherapy in Common Allergic Diseases / Erina M. Lin -- Immunotherapy in Allergic Skin Disease / Hao Cheng -- Traditional Chinese Medicine for Treating Food Allergy and Associated Eczema: From Research to Practice Perspective / Xiu-Min Li -- Immunomodulation by Food / Ingrid van der Meer, Jurriaan Mes, Amrah Weijn, Harry Wichers -- Prospective Studies on Mite (Dermatophagoides farinae) Allergen Immunotherapy in China / Ting-Huan Wen -- The Influence of Pollen Concentration on the Dispension of Antihistaminics and Corticosteroids to Hay Fever Patients / Arnold J.H. van Vliet, Hilde Tobi -- Part V. Hypoallergenic Products. In Search of Hypoallergenic Birch Trees: Characterization of PR-10 Genes from Eight Betula Species and Detection of Bet v 1 Isoforms in Birch Pollen Using a Combined Genomics- Proteomics Approach / M.J.M. Smulders, Martijn F. Schenk, Luud J.W.J. Gilissen -- Hypoallergenic Soybean, from Genes to Cultivar / Rong-Xia Guan, Xu-Qian Fang, Ru-Zhen Chang, Li-Juan Qiu -- Fruit Allergy and Genetic and Genomic Tools to Select Hypoallergenic Fruit Cultivars / Zhong-Shan Gao, Zhao-Wei Yang, Luud Gilissen -- Creating Hypoallergenic Crops through Genetic Modification / Xing-Jun Wang, Han Xia, Shuan-Tao Liu [and others] -- Acceptance of Natural and Genetically Modified Hypoallergenic Apples by Consumers with an Oral Allergy Syndrome (OAS) / I.M. van der Meer, M.F. Schenk, A.R.H. Fischer [and others] -- Cow's Milk Allergens and Technologies to Control Allergenicity / Yong-Kang Luo, Guan-Hao Bu -- Part VI Environment, Hygiene and Societal Issues. Prevalence of Asthma and Asthmatic Symptoms in Children in Relation to Environmental Factors --Epidemiological Studies in School Children in Taiyuan, China / Zhuo-Hui Zhao, Zhuan-Hua Wang, Zheng Zhang [and others] -- The Relationship of Food Allergies and Respiratory Allergies in Urban and Rural Chinese Children / Gary W.K. Wong, Yu-Zhi Chen, Jing Li, Nan-Shan Zhong -- Socio-Economic Issues Associated with Food Allergy / L.J. Frewer, J. Voordouw, M.F. Schenk [and others] -- The Association between Helminth Infections and Atopic Diseases / L.A.H. Hermsen.
  • 2006 Springer
    Bent, Elizabeth; Tuzun, Sadik.
  • 2013 Springer
    Gran, Bruno; Yamamura, T.
    The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "new" MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and-even more-the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that "translation" is real and not just virtual.
  • 2015 Springer Protocols
    Weissert, Robert.
    Positional gene cloning in experimental populations / Maja Jagodic and Pernilla Stridh - - Generation of transgenic rats using lentiviral vectors / Holger M. Reichard and Henrike J. Fischer -- DNA vaccination techniques / Nicolas Fissolo, Xavier Montalban, and Manuel Comabella -- Peripheral blood mononuclear cells : isolation, freezing, thawing, and culture / Christine Riedhammer, Dagmar Halbritter, and Robert Weissert -- ELISPOT techniques / Niannian Ji and Thomas G. Forsthuber -- Isolation of central nervous system (CNS) infiltrating cells / Ilgiz A. Mufazalov and Ari Waisman -- Methods for ex vivo analysis of immune cell function from the central nervous system / Darryl G. Turner ... [et al.] -- Neurofilament light chain determination from peripheral blood samples / Marguerite Limberg ... [et al.] -- Detection of autoantibodies against myelin oligodendrocyte glycoprotein in multiple sclerosis and related diseases / Melania Spadaro and Edgar Meinl -- Myelinating cultures : an in vitro tool to identify demyelinating and axopathic autoantibodies / Maren Lindner and Christopher Linington -- In vivo visualization of (auto-) immune processes in the central nervous system of rodents / Christian Schlager ... [et al.] -- Optical coherence tomography to assess neurodegeneration in multiple sclerosis / Axel Petzold -- Experimental autoimmune encephalomyelitis in mice / Rachael L. Terry, Igal Ifergan, and Stephen D. Miller -- Actively induced experimental autoimmune encephalomyelitis in rats / Robert Weissert -- Experimental autoimmune encephalomyelitis in marmosets / S. Anwar Jagessar ... [et al.]-- Neuropathological techniques to investigate CNS pathology in experimental autoimmune encephalomyelitis (EAE) / Karin Steinbach and Doron Merkler -- Neuropathological techniques to investigate central nervous system sections in multiple sclerosis / Jan Bauer and Hans Lassmann.
  • 2014 ScienceDirect
    Boraschi, D.; Duschl, Albert.
    Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage.
  • v. 1-3, 2008-2010. Springer
    v. 2, 2009 Springer
    v. 3, 2010 Springer
    Georgiev, Vassil St; McGowan, John J.; Western, Karl A.
    v. 1. Frontiers in research -- v. 2. Impact on Global Health -- v. 3. Intramural research.
  • 2005 ScienceDirect
    Bertók, Lóránd; Chow, Donna A.
  • 2016 Springer
    Vivier, E.
    Transcriptional control of NK cells -- Development, homeostasis, and heterogeneity of NK cells -- Diversification and functional specialization of human NK cell subsets -- Dynamic regulation of NK cell responsiveness -- NK cells and cancer immunoediting -- Sweet is the memory of past troubles: NK cells remember -- Lessons from NK cell definiencies in the mouse -- Probing human NK cell biology using human immune system (HIS) mice -- Haploidentical haematopoietic stem cell transplantation: role of NK cells and effect of cytomegalovirus infections -- The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer -- Index.
  • 2010 Springer
    Zimmer, Jacques.
  • 2012 Springer
    Berzofsky, Jay A.; Terabe, Masaki.
    Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi ... [et al.] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes ... [et al.] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders ... [et al.] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
  • 2006 Springer
    Carr, John Peter; Loebenstein, G.
  • 2012 Springer
    Lutz, Hans U.
    Naturally occurring IgM antibodies to oxidation-specific epitopes / Christoph J. Binder -- Naturally occurring autoantibodies to apoptotic cells / Keith B. Elkon and Gregg J. Silverman -- Naturally occurring antibodies directed against carbohydrate tumor antigens / Reinhard Schwartz-Albiez -- Naturally occurring antibodies as therapeutics for neurologic disease : can human monoclonal IgMs replace the limited resource IVIG? / Arthur E. Warrington ... [et al.] -- Nature and nurture of catalytic antibodies / Sudhir Paul ... [et al.] -- Naturally occurring autoantibodies in mediating clearance of senescent red blood cells / Hans U. Lutz -- Naturally occurring autoantibodies against ss-amyloid / Jan-Philipp Bach and Richard Dodel -- Multi-faceted role of naturally occurring autoantibodies in fighting pathogens / Hicham Bouhlal and Srini Kaveri -- Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses / Claus H. Nielsen and Klaus Bendtzen -- Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies / Jaap Kwekkeboom -- Control of B cells expressing naturally occurring autoantibodies / Jean Louis Pasquali and Thierry Martin -- Granulocyte death regulation by naturally occurring autoantibodies / Stephan Von Gunten and Hans-Uwe Simon -- Naturally occurring autoantibodies mediate ischemia/reperfusion-induced tissue injury / Sherry D. Fleming -- How immune complexes from certain IgG NAbs and any F(ab')2 can mediate excessive complement activation / Hans U. Lutz -- The natural autoantibody repertoire in newborns and adults : a current overview / Asaf Madi ... [et al.] -- Antibody polyspecificity : what does it matter? / Jordan D. Dimitrov, Anastas D. Pashov, Tchavdar L. Vassilev -- Positive and negative selection of natural autoreactive B cells / Richard R. Hardy and Kyoko Hayakawa -- Naturally occurring antibodies/autoantibodies in polyclonal immunoglobulin concentrates / Peter J. Späth and Hans U. Lutz.
    Also available: Print – 2012
  • 2011 Springer
    Ahmed, Rafi; Honjo, T.
    TIM-3 and its regulatory role in immune responses / Chen Zhu, Ana C. Anderson and Vijay K. Kuchroo -- Role of PD-1 in regulating T-cell immunity / Hyun-Tak Jin, Rafi Ahmed and Taku Okazaki -- The role of IL-10 in regulating immunity to persistent viral infections / Elizabeth B. Wilson and David G. Brooks -- Inhibitory Ly49 receptors on mouse natural killer cells / Mark T. Orr and Lewis L. Lanier -- Immunoregulatory roles for Fc receptor-like molecules / Götz R.A. Ehrhardt and Max D. Cooper -- Fc[gamma]Rs in health and disease / Falk Nimmerjahn and Jeffrey V. Ravetch -- TGF-[beta] function in immune suppression / Akihiko Yoshimura and Go Muto.
  • 2012 Springer Protocols
    Christodoulides, Myron.
    Neisseria meningitidis: biology, microbiology, and epidemiology -- Classification and pathogenesis of meningococcal infections -- Detection of Neisseria meningitidis in cerebrospinal fluid using a multiplex PCR and the luminex detection technology -- Generating knock-out and complementation strains of Neisseria meningitidis -- Identification and functional characterization of sRNAs in Neisseria meningitidis -- Expression, purification, and crystallization of neisserial outer membrane proteins -- Genome-scale metabolic models: reconstruction and analysis -- TMT labelling for the quantitative analysis of adaptive responses in the meningococcal proteome -- Meningococcal ligands and molecular targets of the host -- In vivo imaging of meningococcal disease dynamics -- Methods for studying Neisseria meningitidis biofilms -- Laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Techniques to measure pilus retraction forces -- Human dendritic cell culture and bacterial infection -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Visualising PAMP-PRR interactions using nanoscale imaging -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- Analysis of the immune response to Nia meningitidis using a proteomics approach -- Antigen identification starting from the genome: a "reverse vaccinology" approach applied to MenB -- DNA vaccine strategy for effective antibody induction to pathogen-derived antigens.
  • 2005 Springer
    Bona, Constantin A.
    Structure and function of immune system in vertebrates -- Ontogeny and development of cells mediating innate and adaptive immunity -- Phenotypic characteristics of neonatal B cells -- Molecular characteristics of neonatal B cell repertoire -- Genetically programmed temporal ordered activation of neonatal B cell clones -- Antibody response in fetus and newborn -- Effect of maternal antibodies on neonatal B cell response -- Neonatal autoimmune diseases caused by maternal pathogenic autoantibodies -- Phenotypic characteristics of neonatal T cells -- Expression of MHC molecules in neonates -- Neonatal cytokine network -- Cell-mediated immune responses in neonates -- Fetal and neonatal tolerance -- Development of efficient prophylactic vaccines and theracines for newborns and infants .
  • 2012 Springer
    Levite, Mia.
    Dopamine in the Immune System: Dopamine Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Immune and Neuropsychiatric Diseases -- Nerve Driven Immunity: Noradrenaline and Adrenaline -- Acetylcholine and Cholinergic Modulation of Immune Responses -- Glutamate in the Immune System: Glutamate Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Disease -- GABA Is an Effective Immunomodulatory Molecule in the Brain and in the Periphery -- The Effects of Opioids on Immune Cells, Functions and Diseases -- The Effects of Somatostatin on Immune Cells, Functions and Diseases -- Neuropeptide Y: The Story, the Players, the Outcomes -- Vasoactive Intestinal Peptide: Immune Mediator and Potential Therapeutic Agent -- Nerve-Driven Immunity: The Effects of Neurotransmitters on Immune Cells, Functions and Disease -- CGRP -- The Effects of Cannabinoids on Immune Cells, Responses and Diseases.
  • 2010
    Clutter, Matthew Ryan; Chen, James K.; Davis, Mark M.; Galli, Stephen J.; Nolan, Garry P.
    Target identification is both a critical and difficult step in the drug discovery process. A novel approach is presented here that utilizes flow cytometry to: 1) identify small molecule signaling network probes, and 2) characterize the diverse network activation states they induce. Signaling events across the network are compared to functional responses to determine the way in which each signaling node influences a given function. Nodes that accurately predict cellular functions that drive disease are promising drug targets. The approach was applied to mast cells to determine which signaling molecules best predicted the degranulation, eicosanoid release, and cytokine secretion induced by stimulation of the cells with IgE and specific antigen crosslinking. Erk and Akt phosphorylation best predicted degranulation; Erk and cJun phosphorylation best predicted eicosanoid release; and Akt phosphorylation alone best predicted cytokine secretion. The results confirmed several known aspects of mast cell IgE-dependent signaling and revealed unknown associations to be tested in future work -- notably, that the cJun pathway plays a role in eicosanoid production and that the Akt pathway is a critical integration point for transcription of most or all cytokine genes. Overall, the results suggest that Erk and Akt are the most promising targets in the IgE signaling network for development of mast cell stabilizing drugs.
  • 2008 Springer
    Eichmann, Klaus.
  • 2009 ScienceDirect
    Jancsó, Gábor.
  • 2009 Springer
    Siegel, Allan; Zalcman, Steven.
  • 2007 Springer
    Pandi-Perumal, S. R.; Cardinali, Daniel P.; Chrousos, George P.
  • 2009 Springer
    Granstein, Richard D.; Luger, Thomas A.
  • 2014 Springer Protocols
    Deleo, Frank; Quinn, Mark Thomas.
    The role of neutrophils in the immune system : an overview / Harry L. Malech, Frank R. DeLeo, and Mark T. Quinn -- Isolation of human neutrophils from venous blood / William M. Nausef -- Neutrophil isolation from nonhuman species / Daniel W. Siemsen ... [and 7 others] -- Collection of in vivo transmigrated neutrophils from human skin / Karin Christenson ... [and 6 others] -- Subcellular fractionation of human neutrophils and analysis of subcellular markers / Stine Novrup Clemmensen, Lene Udby, and Niels Borregaard -- Rho family and Rap GTPase activation assays / Richard T. Jennings and Ulla G. Knaus -- Measurement of phospholipid metabolism in intact neutrophils / Susan Sergeant and Linda C. McPhail -- Optical methods for the measurement and manipulation of cytosolic calcium signals in neutrophils / Maurice B. Hallett, Maha Al-Jumaa, and Sharon Dewitt -- Analysis of electrophysiological properties and responses of neutrophils / Deri Morgan and Thomas E. DeCoursey -- Assessment of neutrophil apoptosis / David A. Dorward ... [and 3 others] -- Microinjection methods for neutrophils / Iraj Laffafian ... [and 3 others] -- Generation of functionally mature neutrophils from induced pluripotent stem cells / Colin L. Sweeney ... [and 6 others] -- Neutrophil migration through extracellular matrix / Richard T. Jennings and Ulla G. Knaus -- Spinning disk confocal imaging of neutrophil migration in zebrafish / Pui-Ying Lam ... [and 4 others] -- Detection of bidirectional signaling during integrin activation and neutrophil adhesion / Stuart M. Altman, Neha Dixit, and Scott I. Simon -- Immunofluorescence and confocal microscopy of neutrophils / Lee-Ann H. Allen -- Expressin of genetically encoded fluorescent probes to monitor phospholipid dynamics in live neutrophils / Benjamin E. Steinberg, Marco A.O. Magalhaes, and Sergio Grinstein -- Quantitative assessment of neutrophil phagocytosis using flow cytometry / Pontus Nordenfelt -- Analysis of neutrophil bactericidal activity / Heather A. Parker ... [and 4 others] -- Induction and quantification of neutrophil extracellular traps / Alejandro Sanchez Gonzalez ... [and 3 others] -- Measurement of respiratory burst products, released or retained, during activation of professional phagocytes / Johan Bylund ... [and 4 others] -- Cell-free NADPH oxidase activation assays : "In vitro veritas" / Edgar Pick -- Assessment of priming of the human neutrophil respiratory burst / Margarita Hurtado-Nedelec ... [and 4 others] -- Affinity pruification and reconstitution of human phagocyte flavocytochrome b for detection of conformational dynamics in the membrane / Marcia Riesselman and Algirdas J. Jesaitis -- Evaluation of p47phox phosphorylation in human neutrophils using phospho-specicfic antibodies / Sahra Amel Belambri, Pham My-Chan Dang, and Jamel El-Benna -- Genome-scale transcript analyses with human neutrophils / Scott D. Kobayashi, Daniel E. Sturdevant, and Frank R. DeLeo -- Fast and accurate quantitative analysis of cytokine gene expression in human neutrophils / Nicola Tamassia, Marco A. Cassatella, and Flavia Bazzoni -- High-purity neutrophil isolation from human peripheral blood and saliva for transcriptome analysis / Flavia S. Lakschevitz and Michael Glogauer -- Detection of intact transciption factors in human neutrophils / Patrick P. McDonald and Richard D. Ye -- Disorders of neutrophil function : an overview / Mary C. Dinauer -- Diagnostic assays for chronic granulomatous disease and other neutrophil disorders / Houda Zghal Elloumi and Steven M. Holland -- Diagnostic assays for myeloperoxidase and myeloperoxidase deficiency / William M. Nauseef.
  • 2001 ScienceDirect
    Berczi, Istvan; Gorczynski, Reginald M.
  • 2013 Springer
    Divangahi, Maziar.
    Also available: Print – 2013
  • 2013 Springer
    Heber-Katz, E.; Stocum, David L.
    Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis / Mateusz S. Wietecha, Wendy L. Cerny, Luisa A. DiPietro -- Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals / Aiko Kawasumi, Natsume Sagawa, Shinichi Hayashi -- Cellular Plasticity During Vertebrate Appendage Regeneration / James R. Monaghan, Malcolm Maden -- Cell Signaling Pathways in Vertebrate Lens Regeneration / Jonathan J. Henry, Alvin G. Thomas, Paul W. Hamilton -- Regenerative Medicine: Challenges and Perspectives for Successful Therapies / S. Viswanathan, C. Joshi -- Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects / Jo Ann Cameron, Derek J. Milner, Jung Seok Lee -- Muscle Repair and Regeneration: Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration / Derek J. Milner, Jo Ann Cameron -- Neural Regeneration / Melissa M. Steward, Akshayalakshmi Sridhar -- Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System / Günther K. H. Zupanc, Ruxandra F. Sîrbulescu -- Epigenetics and Regeneration / Nobuyasu Maki, Hironobu Kimura -- Cell Cycle Regulation and Regeneration / Ellen Heber-Katz, Yong Zhang, Khamila Bedelbaeva.
  • 2012 Karger
    Behrendt, H.; Darsow, U.; Ring, Johannes.
    Allergy in evolution / Platts-Mills, T.A.E. -- Climate change, environment and allergy / Behrendt, H., Ring, J. -- The hygiene hypothesis does not apply to atopic eczema in childhood / Cramer, C. ... [et al.] -- Molecular genetics of atopic eczema / Ring, J., Mohrenschlager, M., Weidinger, S. -- Mechanisms of immune tolerance to allergens / Fujita, H. ... [et al.] -- TH17 and TH22 in skin allergy / Cavani, A., Pennino, D., Eyerich, K. -- IL-25 induces both inflammation and skin barrier dysfunction in atopic dermatitis / Deleuran, M. ... [et al.] -- Angiogenesis, lymphangiogenesis and atopic dermatitis / Genovese, A. ... [et al.] -- What can dogs bring to atopic dermatitis research? / Olivry, T. -- Can microbial superantigens influence atopic dermatitis flares? / Alomar, A. -- Inflammation-induced alterations in the skin barrier function: implications in atopic dermatitis / Vestergaard, C. ... [et al.] -- Itch and eczema / Darsow, U. -- Eczema herpeticum / Wollenberg, A. -- Bone mineral density in patients with atopic dermatitis / Haeck, I. -- Immunosuppressive effect of prolactin-induced protein / Sugiura, S. ... [et al.] -- Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study / Keck, L.E. ... [et al.] -- New strategies for dealing with staphylococcus aureus colonization and the emerging methicillin-resistant staphylococcus aureus epidemic in atopic dermatitis / Boguniewicz, M. -- Anti-IL-4 as a new strategy in allergy / Schmidt-Weber, C.B. -- New drug targets in atopic dermatitis / Simon, D., Simon, H.U. -- Latest approaches to treating atopic dermatitis / Paller, A.S.
  • 2011 Springer
    Karin, Michael.
    Understanding the logic of I[kappa]B:NF-[kappa]B regulation in structural terms / Tom Huxford, Alexander Hoffmann and Gourisankar Ghosh -- NF-[kappa]B/Rel proteins and the humoral immune responses of Drosophila melanogaster / Sandhya Ganesan ... [et al.] -- Specialized chromatin patterns in the control of inflammatory gene expression / Gioacchino Natoli -- IKK regulation and human genetics / Giles Courtois and Alain Israel -- Control of NF-[kappa]B activity by proteolysis / Veronique Baud and Emmanuel Derudder -- NF-[kappa]B and Innate immunity / Anurupa Dev ... [et al.] -- NF-[kappa]B and mucosal homeostasis / Lars Eckmann and Andrew S. Neish -- IKK- and NF-[kappa]B-mediated functions in carcinogenesis / Melek C. Arkan and Florian R. Greten -- Macrophages and NF-[kappa]B in cancer / Toby Lawrence -- NF-[kappa]B in liver cancer : The plot thickens / Shlomi Finkin and Eli Pikarsky -- NF-[kappa]B as a target for oncogenic viruses / Shao-Cong Sun and Ethel Cesarman -- Inhibition of NF-[kappa]B signaling as a strategy in disease therapy / Thomas D. Gilmore and Michael R. Garbati.
  • 2012 Springer
    Radtke, Freddy.
    The Notch Pathway in Hematopoietic Stem Cells / Anna Bigas, Teresa D'Altri and Lluis Espinosa -- Notch Receptor-Ligand Interactions During T Cell Development, a Ligand Endocytosis-Driven Mechanism / Divya K. Shah and Juan Carlos Zúñiga-Pflücker -- Notch1 and IL-7 Receptor Signalling in Early T-cell Development and Leukaemia / Sara González-García, Marina García-Peydró, Juan Alcain and María L. Toribio -- Notch Signaling During Human T cell Development / Tom Taghon, Els Waegemans and Inge Van de Walle -- Canonical and Non-Canonical Notch Signaling in CD4+ T Cells / Lisa M. Minter and Barbara A. Osborne -- The Role of Notch in the Differentiation of CD4+ T Helper Cells / Floriane Auderset, Manuel Coutaz and Fabienne Tacchini-Cottier -- Notch Signaling in Alloreactive T Cell Immunity / Jooho Chung and Ivan Maillard -- Notch2 and Immune Function / Mamiko Sakata-Yanagimoto and Shigeru Chiba -- Recent Advances on NOTCH Signaling in T-ALL / Gannie Tzoneva and Adolfo A. Ferrando.
  • 2013 Springer
    Manmohan Singh.
  • 2011 Future Med
    De Gregorio, Ennio; Rappuoli, Rino.
    Novel immunologic adjuvants / R. Rappuoli & E. De Gregorio -- Rationales for including adjuvants in vaccines / V.E.J.C. Schijns & E.C. Lavelle -- New alum combinations / S. Awate, N.F. Eng & G.K. Mutwiri -- Oil emulsions as vaccine adjuvants / J. Haensler -- Virosomes / C. Moser -- Saponin QS-21 adjuvants in cancer vaccines / G. Ragupathi, J.R. Gardner, D.Y. Gin & P.O. Livingston -- TLR4 agonists as effective vaccine adjuvants / J. Baldridge -- TLR7/8 agonists / M.A. Tomai & J.P. Vasilakos -- TLR9 agonists / G. Zhao, D. Tross & D.M. Klinman -- Future trends of novel vaccine adjuvants / V.E.J.C. Schijns & E.C. Lavelle.
  • 2013 Future Med
    Cutolo, M.
    Novel insights into systemic sclerosis management / Maurizio Cutolo & Vanessa Smith -- New systemic sclerosis classification criteria / Sindhu R. Johnson & Oliver Distler -- Pathophysiology of systemic sclerosis / Veronica Codullo, Oliver Distler & Carlomaurizio Montecucco -- Genetics of systemic sclerosis / Eloisa Romano, Mirko Manetti, Yannick Allanore, Marco Matucci-Cerinic & Serena Guiducci -- Very early and early diagnosis of systemic sclerosis / Gemma Lepri, Silvia Bellando Randone, Cosimo Bruni, Marco Matucci-Cerinic & Serena Guiducci -- Role of capillaroscopy in diagnosis and prediction of clinical complications / Vanessa Smith & Maurizio Cutolo -- Medications for skin symptoms / Lucas L. van den Hoogen & Frank H.J. van den Hoogen -- Renal involvement and management in systemic sclerosis / Tracy Frech -- Value of early diagnosis of pulmonary arterial hypertension associated with systemic sclerosis / Eric Hachulla, Christopher Denton & Gerry Coghlan -- Advances in the diagnosis and assessment of primary cardiac involvement in systemic sclerosis / Christophe Meune & Yannick Allanore -- Gastrointestinal tract involvement and management / Genevieve Gyger & Murray Baron -- Treatment decisions in interstitial lung disease / Snigdha Jain, Anupama Shahane & Chris T. Derk -- Treatment of ulcers in systemic sclerosis / Cosimo Bruni, Francesca Braschi, Ginevra Fiori, Felice Galluccio, Francesca Bartoli, Serena Guiducci & Marco Matucci-Cerinic -- Treatment of systemic sclerosis : tyrosine kinase inhibitors / Fabian A. Mendoza, Joel Rosenbloom & Sergio A. Jimenez -- Therapeutic potentials of IL-6 inhibition for systemic sclerosis / Yoshihito Shima & Masataka Kuwana -- Rituximab : a new approach for systemic sclerosis? / Dimitrios Daoussis, Vanessa Smith & Andrew P Andonopoulos -- How to approach early and late Raynaud's phenomenon in systemic sclerosis / Julie Paik & Fredrick M. Wigley -- Prophylactic ACE inhibitor therapy in Raynaud's phenomenon : helpful or harmful? / Michael Hughes & Ariane Herrick -- Update on juvenile systemic sclerosis / Ivan Foeldvari -- Index.
  • 2005 Springer
    Feuerstein, Giora Z.; Zukowska, Zofia.
    Also available: Print – 2005
  • 2008 CRCnetBASE
    Akira, Shizuo; Ishii, Ken J.
    Clinical development of oligodeoxynucleotide TLR9 agonists / by Julie L. Himes and Arthur M. Krieg -- Prospects for TLR9- based immunotherapy for asthma and allergy / by David Broide -- Toll-like receptors in the development of systemic autoimmune disease : in vitro artifact or in vivo paradigm? / by Ann Rothstein -- Impacts of nucleoside modification on RNA-mediated activation of toll-like receptors / by Katalin Kariko and Drew Weissman -- Activation of innate pattern recognition pathways by single-stranded ribonucleic acids / by Sandra Diebold -- RNA interference in scope of immune system / by Andrea Ablasser, Gunther Hartmann, and Veit Hornung -- Recognition of RNA and synthetic compounds by TLR7 and TLR8 / by Svetlana Hamm and Stefan Bauer -- Helicases at frontline of RNA virus recognition / by Leonid Gitlin and Marco Colonna. Structural analysis of toll-like receptors / by Jungwoo Choe and Ian A. Wilson -- Antiviral signaling through TLRs and RLHs / by Taro Kawai -- Recognition of virus invasion by toll-like receptors and RIG-I-like helicases / by Hiroki Kato and Osamu Takeuchi -- Characteristics of dendritic cell responses to nucleic acids / by Tsuneyasu Kaisho, Takahiro Sugiyama, and Katsuaki Hoshino -- Dendritic cells as sensors for foreign and self nucleic acids / by Anne Krug and Wolfgang Reindl -- Natural DNA recognition by toll-like receptor 9 does not reply upon CpG motifs: role of endosomal compartmentation / by Tobias Haas ... [et al.] -- Discrimination of self and non-self DNA / by Katryn J. Stacey ... [et al.] -- Therapeutic potential of immunosuppressive oligonucleotides expressing TTAGGG motifs / by Dennis M. Klinman ... [et al.] -- Structure/function of IFN?-inducing CpG ODN / by Daniela Verthelyi and Montserrat Puig --
  • 2015 CRCnetBASE
    Abrams, S. A.; Pammi, Mohan; Vallejo, Jesus G.
    Role of nutrition in human health and disease / David C. Hilmers and Steven A. Abrams -- Interaction of nutrition and immunity / Ebenezer Satyaraj and John E. Morley -- Micronutrient deficiency and immunity / Sarah E. Cusick and John C. Chandy -- Infection-nutrition interaction: perspectives from the developing world in transition / Noel W. Solomons and Anne-Marie Chomat -- Role of oxidative stress and inflammation in nutrition-infection interactions and the potential therapeutic strategy using antioxidants and modulating inflammation / Elena Puertollano and Maria A. Puertollano -- Nutrient-drug interactions / Kathleen M. Gura -- HIV/AIDS and micronutrient supplementation / Elaine A. Yu, Julia L. Finkelstein, and Saurabh Mehta -- Tuberculosis and human nutrition / Kee Thai Yeo and Anna Mandalakas -- Impact of malaria and parasitic infections on human nutrition / Athis Arunachalam, Vedanta Dariya, and Celia Holland -- Gut microbiome in the nutrition-infection interaction : a focus on malnourished children / Dorottya Nagy-Szakal, Richard Kellermayer, and Sanjiv Harpavat -- Enteric syndromes leading to malnutrition and infections / Lier Goh and Praveen S. Goday -- Probiotics, prebiotics, synbiotics on infections, immunity, and nutrition / Diomel de la Cruz and Josef Neu -- Immunonutrients and evidence for their use in hospitalized adults receiving artificial nutrition / Philip C. Calder -- Impact of infection-nutrient interactions in infants, children and adolescents / Renán A. Orellana and Jorge A. Coss-Bu -- Aging and effects of nutrient-infection interactions / Sung Nim Han -- Future strategies and research directions in nutrition-infection interactions that will enhance human health / Mohan Pammi, Jesus G. Vallejo, and Steven A. Abrams.
  • 2013 Springer
    Daszak, Peter; Jeggo, Martyn; Mackenzie, John S.; Richt, J. A.
    The second volume on One Health explains in detail how to implement three key aspects of the One Health paradigm food safety and security, national plans for a holistic one health approach, and relevant new technologies and approaches. The fourteen chapters, each by an internationally recognized authority, are organized into three sections of four or five chapters each, that break new ground in clarifying precisely how One Health can become an operational reality in local, national and international public health initiatives. Section three begins with an international overview on food safety and security. The importance of a One Heath approach is then explained in relation to four specific problems?the growing prevalence of antibiotic resistance, bovine spongiform encephalopathy and pathogenic E.coli. Section four begins with the role of the Food and Agricultural Organization (FAO) in promoting One Health. The formulation and implementation of national plans for implementing the One Health paradigm are then set out for Africa, the Western Pacific, Southeast Asia and Mongolia. The final section of this two volume book is devoted to implementing new technologies and new approaches to One Health. A wide-ranging analysis considers the importance of climate change and a social-ecological systems approach, as well as how to operationalize One Health, how to move from emergency response to prevention at source, and how to implement an educational strategy that builds a foundation for One Health in emerging disease management. It is anticipated that this two volume book will become a benchmark for practitioners of One Health, empowering a balanced multidisciplinary approach to the complexities of the human-animal-environment interface.
  • 2013 Springer
    Daszak, Peter; Jeggo, Martyn; Mackenzie, John S.; Richt, J. A.
    One Health: its origins and future -- One Health and emerging infectious diseases: clinical perspectives -- The historical, present, and future role of veterinarians in One Health -- The importance of understanding the human-animal interface -- The human environment interface: applying ecosystem concepts to health -- Wildlife: the need to better understand the linkages -- The economic value of One Health in relation to the mitigation of zoonotic disease risks -- The application of One Health approaches to henipavirus research -- H5N1 highly pathogenic avian influenza in Indonesia: retrospective considerations -- Rabies in Asia: the classical zoonosis -- Japanese encephalitis: on the One Health agenda -- Cost estimate of bovine tuberculosis to Ethiopia -- The pandemic H1N1 influenza experience -- One Health: the Hong Kong experience with avian influenza -- Clostridium difficile infection in humans and piglets: a 'One Health' opportunity -- Men, primates, and germs: an ongoing affair -- Erratum to: Cost estimate of bovine tuberculosis to Ethopia -- Index.
  • 2007 Springer
    Choi, Yongwon.
    Also available: Print – 2007
  • 2010 Springer
    Choi, Yongwon.
    The role of bone marrow edema and lymphangiogenesis in inflammatory-erosive arthritis / Edward M. Schwarz ... [et al.] -- Activation of [gamma][delta] T cells by bisphosphonates / Keith Thompson ... [et al.] -- Identification of cell cycle-arrested quiescent osteoclast precursors in vivo / Naoyuki Takahashi ... [et al.] -- Megakaryocyte-bone cell interactions / Melissa A. Kacena and Wendy A. Ciovacco -- Regulation of osteoblast differentiation by Runx2 / Toshihisa Komori -- Communication between ephrinB2 and ephB4 within the osteoblast lineage / T.J. Martin ... [et al.] -- The unexpected link between osteoclasts and the immune system / Hiroshi Takayanagi -- NFATc1 in inflammatory and musculoskeletal conditions / Antonios O. Aliprantis and Laurie H. Glimcher -- Novel functions of RANK(L) signaling in the immune system / Andreas Leibbrandt and Josef M. Penninger -- Eph and ephrin interactions in bone / Koichi Matsuo -- How do bone cells secret proteins? / Haibo Zhao ... [et al.] -- Regulation of osteoclast apoptosis by Bcl-2 family protein Bim and caspase-3 / Sakae Tanaka ... [et al.] -- Regulation of bone formation and immune cell development by Schnurri proteins / Dallas C. Jones and Laurie H. Glimcher.
    Also available: Print – 2010
  • 2013 Springer
    Choi, Yongwon.
    Bone and the immune system are both complex tissues, which, respectively, regulate the skeleton and the body's responses to invading pathogens. It has become increasingly clear that critical interactions between these two organ systems frequently occur. This is particularly true for the development of immune cells in the bone marrow and for the function of bone cells in health and disease. However, because these two disciplines developed independently, investigators in each don't always fully appreciate the significance of the other. This book is meant to provide a detailed overview of the many ways that bone and immune cells interact. The goal is to provide basic and clinical scientists with a better understanding of the role that the immune system and bone play in the development and function of each other so that advances in both fields will be facilitated. The focus of the book will be both on basic pathways and translational science, which will apply basic knowledge to clinical diseases. Chapter content will range from basic descriptions of the various cell systems and their development to the signals that cause them to interact during normal physiology and disease. Approximately half the book will focus on the role that osteoimmunology plays in the development of human diseases.
  • 2011 ScienceDirect
    Lorenzo, Joseph.
    1. Overview: The Developing Field of Osteoimmunology / Joseph Lorenzo, Yongwon Choi, Mark Horowitz, Hiroshi Takayanagi -- 2. Origins of Osteoclasts / Deborah L. Galson, G. David Roodman -- 3. The Adaptive Immune Response / David G. Hesslein, Hector L. Aguila, Mark C. Horowitz -- 4. The Role of Bone Cells in Establishing the Hematopoietic Stem Cell Niche / Joy Y. Wu, Henry M. Kronenberg -- 5. Osteoblasts and their Signaling Pathways: New Frontiers for Linkage to the Immune System / Jane B. Lian, Ellen M. Gravallese, Gary S. Stein -- 6. The Osteoclast: The Pioneer of Osteoimmunology / Roberta Faccio, Yongwon Choi, Steven L. Teitelbaum, Hiroshi Takayanagi -- 7. The Effects of Immune Cell Products (Cytokines and Hematopoietic Cell Growth Factors) on Bone Cells / Joseph Lorenzo -- 8. Interactions Among Osteoblasts, Osteoclasts, and Other Cells in Bone / T. John Martin, Natalie A. Sims, Julian M.W. Quinn -- 9. The Role of the Immune System in the Development of Osteoporosis / Ulrike I. Mödder, B. Lawrence Riggs, Sundeep Khosla -- 10. The Role of the Immune System in the Bone Loss of Inflammatory Arthritis / Steven R. Goldring, Georg Schett -- 11. Inflammatory Bowel Disease and Bone / Francisco A. Sylvester, Anthony T. Vella -- 12. The Role of the Immune System in Fracture Healing / Brandon M. Steen, Louis C. Gerstenfeld, Thomas A. Einhorn -- 13. The Role of the Immune System and Bone Cells in Acute and Chronic Osteomyelitis / Brendan F. Boyce, Lianping Xing, Edward M. Schwarz -- 14. The Role of the Immune System in Hematologic Malignancies that Affect Bone / Jessica A. Fowler, Claire M. Edwards, Gregory R. Mundy -- 15. Osteoimmunology in the Oral Cavity (Periodontal Disease, Lesions of Endodontic Origin and Orthodontic Tooth Movement) / Dana T. Graves, Rayyan A. Kayal, Thomas Oates, Gustavo P. Garlet.
  • 2011 Springer
    Chiappelli, Francesco.
  • 2014 Springer
    Camps, Jordi.
    Introduction: Oxidation and inflammation, a molecular link between non-communicable diseases -- Oxidative stress and DNA damage in obesity-related tumorigenesis -- High density lipoproteins and ischemia reperfusion injury: the therapeutic potential of HDL to modulate cell survival pathways -- The DING family of phosphate binding proteins in inflammatory diseases -- Inflammation, infection, cancer and all that...the role of paraoxonases -- Autophagy is an inflammation-related defensive mechanism against disease -- Delta-5 and delta-6 desaturases: crucial enzymes in polyunsaturated fatty acid-related pathways with pleiotropic influences in health and disease -- Systemic inflammation, intestine and paraoxonase-1 -- Serotonin modulation of macrophage polarization: inflammation and beyond -- Energy metabolism and metabolic sensors in stem cells: the metabostem crossroads of aging and cancer -- Molecular promiscuity of plant polyphenols in the management of age-related diseases: far beyond their antioxidant properties -- Postprandial inflammation: targeting glucose and lipids -- Dynamic interplay between metabolic syndrome and immunity -- The axis AGE-RAGE-soluble RAGE and oxidative stress in chronic kidney disease -- The chemokine (C-C motif) ligand 2 in neuroinflammation and neurodegeneration.
    Also available: Print – 2014
  • 2006 Karger
    Capron, Monique; Trottein, Franc̦ois.
    Also available: Print – 2006
  • 2009 Springer
    Lachapelle, Jean-Marie; Maibach, Howard I.
  • 2012 Springer
    Lachapelle, Jean-Marie; Maibach, Howard I.
  • 2014 Springer
    Bruze, Magnus; Elsner, Peter; Lachapelle, Jean-Marie.
    This book is a compendium of tips on many different aspects of patch testing based on the recommendations of the International Contact Dermatitis Research Group (ICDRG), which is the reference group for all dermato-allergologists. It is intended to complement the book Patch Testing and Prick Testing: A Practical Guide by J.-M. Lachapelle and H. Maibach, which is an official publication of the ICDRG now in its third edition. Among the wide variety of topics covered are pitfalls, legal aspects, patch testing with ultrasonic bath extracts, the role of patch testing in occupational contact dermatitis and atopic dermatitis, semi-open tests, the implications of a negative test, patch testing validity, selection of extra allergens and patch testing in the tropics. Many illustrations are included and all information is completely up-to-date. This book will be of value to all practicing dermatologists.
  • 2009 Springer
    Fallon, Padraic G.
    Bacterial toxins as immunomodulators / David S. Donaldson and Neil A. Williams -- Innate immune evasion by staphylococci / Karin Ellen Veldkamp and Jos A.G. van Strijp -- Bacterial complement escape / Ilse Jongerius, Sanjay Ram, and Suzan Rooijakkers -- Modulation of innate immune signalling pathways by viral proteins / Orla Mulhern, Barry Harrington, and Andrew G. Bowie -- Viral TNF inhibitors as potential therapeutics / Masmudur M. Rahman, Alexandra R. Lucas, and Grant McFadden -- Lipoxins as an immune-escape mechanism / Fabiana S. Machado and Julio Aliberti -- Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES62 / William Harnett and Margaret M. Harnett -- Helminth-derived immunomodulatory molecules / Poom Adisakwattana ... [et al.] -- Fungal-derived immune modulating molecules / Tania C. Sorrell and Sharon C.A. Chen -- The immunosuppresive tick salivary protein, Salp15 / Ignacio J. Juncadella and Juan Anguita -- The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics / Alexandra Lucas ... [et al.] -- Helminthic therapy : using worms to treat immune-mediated disease / David E. Elliott and Joel V. Weinstock -- Chemokine binding proteins encoded by pathogens / Antonio Alcami and Margarida Saraiva.
    Also available: Print – 2009
  • 2012 Springer
    Embers, Monica E.
    This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites.
  • 2011 Springer
    Leong, Anthony S.-Y.
    Handling of the lymph node biopsy -- Immunohistology and other diagnostic techniques -- Anatomical and functional components -- Nodular lymphoid infiltrates -- Diffuse lymphoid infiltrations -- Defining microscopic features -- Nodal involvement by leukemias and extranodal lymphomas -- Needle core biopsies and aspirates.
  • 2009 Ovid
    Grammer, Leslie Carroll; Greenberger, Paul A.; Patterson, Roy.
    Review of immunology -- Immunology of IgE-mediated and other hypersensitivity responses -- Biochemical mediators of allergic reactions -- Evaluation and management of immune deficiency in allergy practice -- Evaluation of eosinophilia -- Allergens and other factors important in atopic disease -- Airborne pollen prevalence in the United States -- Diagnosis of immediate hypersensitivity -- Physiologic and biologic evaluation of allergic lung diseases -- Radiologic evaluation of allergic and related diseases of the upper airway -- Radiologic evaluation of allergic and related diseases of the lower airway -- Chronic rhinosinusitis role of rhinoscopy and surgery -- Principles of immunologic management of allergic diseases due to extrinsic antigens -- Anaphylaxis -- Allergy to stinging insects -- Erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis -- Drug allergy -- Food allergies -- Asthma -- The infant and toddler with asthma -- Management of acute severe asthma -- Asthma clinical trials -- Hypersensitivity pneumonitis -- Allergic bronchopulmonary aspergillosis -- Occupational immunlogic lung disease -- Allergic rhinitis -- Nasal polyposis, sinusitis, and nonallergic rhinitis -- Allergic diseases of the eye and ear -- Atopic dermatitis -- Contact dermatitis -- Urticaria, angioedema, and hereditary angioedema -- Approach to the patient with pruritus -- Antihistamines -- β [beta] agonists -- Corticosteroids in treatment of allergic diseases -- Other antiallergic drugs: cromolyn, nedocromil, antileukotrienes, anticholinergics, and theophylline -- Delivery devices for inhaled medications -- Novel immunologic therapies -- Allergic disorders and pregnancy -- Eosinophilic esophagitis -- Chronic cough -- Sleep disorders in the allergic patient -- Management of the psychologically complicated patient -- Controversial and unproved methods in allergy diagnosis and treatment.
  • 2008 Springer
    Cantani, Arnaldo.
  • 2016 ClinicalKey
    Akdis, Cezmi A.; Bonilla, Francisco A.; Leung, Donald Y. M.; Sampson, Hugh A.; Szefler, S. J.
  • 2015 Springer Protocols
    Houen, Gunnar.
    Peptide Antibodies: Past, Present, and Future / Gunnar Houen -- Structure of natural and recombinant antibodies / Hui Ma and Richard O'Kennedy -- Prediction of antigenic B and T cell epitopes via energy decomposition analysis : description of the web-based prediction tool BEPPE / Claudio Peri ... [et al.] -- Prediction of antibody epitopes / Morten Nielsen and Paolo Marcatili -- Fmoc solid-phase peptide synthesis / Paul R. Hansen and Alberto Oddo -- Peptide-carrier conjugation / Paul R. Hansen -- Solid-phase peptide-carrier conjugation / Gunnar Houen and Dorthe T. Olsen -- Analysis of peptides and conjugates by amino acid analysis / Peter Højrup -- Characterization of synthetic peptides by mass spectrometry / Bala K. Prabhala ... [et al.] -- Interpretation of tandem mass spectrometry (MSMS) spectra for peptide analysis / Karin Hjernø and Peter Højrup -- Polyclonal Peptide Antisera / Tina H. Pihl, Kristin E. Illigen, and Gunnar Houen -- Production and screening of monoclonal peptide antibodies / Nicole Hartwig Trier ... [et al.] -- Production of epitope-specific antibodies by immunization with synthetic epitope peptide formulated with CpG-DNA- liposome complex without carriers / Dongbum Kim, Younghee Lee, and Hyung-Joo Kwon -- Thioredoxin-displayed multipeptide immunogens / Angelo Bolchi ... [et al.] -- Purification of natural and recombinant peptide antibodies by affinity chromatographic strategies / Hui Ma and Richard O'Kennedy -- Isolation of camelid single-domain antibodies against native proteins using recombinant multivalent peptide ligands / Norah A. Alturki ... [et al.] -- Generation of TCR-Like antibodies using phage display / Brian H. Santich ... [et al.] -- Structural characterization of peptide antibodies/ Anna Chailyan and Paolo Marcatili -- Automated high-throughput mapping of linear B-cell epitopes using a statistical analysis of high-density peptide microarray data / Thomas Østerbye and Søren Buus -- Characterization of peptide antibodies by epitope mapping using resin-bound and soluble peptides / Nicole Hartwig Trier -- Screening and characterization of linear B-cell epitopes by biotinylated peptide libraries / Ida Rosenkrands and Anja Olsen -- Bead-based peptide arrays for profiling the specificity of modification state-specific antibodies / Angela Filomena ... [et al.] -- Surface plasmon resonance method to evaluate anti-citrullinated protein/peptide antibody affinity to citrullinated peptides / Feliciana Real-Fernández ... [et al.] -- Specificity analysis of histone modification-specific antibodies or reading domains on histone peptide arrays / Goran Kungulovski ... [et al.] -- Prion-specific antibodies produced in wild-type mice / Peter M. H. Heegaard ... [et al.] -- Immunoblotting with peptide antibodies : differential immunoreactivities caused by certain amino acid substitutions in a short peptide and possible effects of differential refolding of the peptide on a nitrocellulose or PVDF membrane / Takenori Yamamoto ... [et al.] -- Immunocytochemical and immunohistochemical staining with peptide antibodies / Tina Friis ... [et al.] -- Designing B-cell epitopes for immunotherapy and subunit vaccines / Harinder Singh ... [et al.] -- Enterovirus-specific anti-peptide antibodies / Chit Laa Poh ... [et al.] -- Therapeutic HIV peptide vaccine / Anders Fomsgaard.
  • 2013 Future Med
    Weinstock-Guttman, Bianca.
    Personalized management of multiple sclerosis / Bianca Weinstock-Guttman, Murali Ramanathan & Robert Zivadinov -- Epidemiology and classification / Julia Pakpoor & Sreeram V. Ramagopalan -- Pathophysiology of multiple sclerosis : a controversial new perspective / Johannes M. van Noort & Sandra Amor -- Symptoms and diagnosis of multiple sclerosis / Eva Havrdová & Jana Lizrova Preiningerova -- Management of acute multiple sclerosis attacks / Finn T. Sellebjerg -- Disease-modifying treatments for relapsing-remitting multiple sclerosis / Per Soelberg Sørensen -- Disease-modifying treatments for secondary progressive and progressive relapsing multiple sclerosis / Laura J. Edwards & Cris Constantinescu -- Head-to-head versus therapy-change studies / Carlo Pozzilli & Luca Prosperini -- MRI as a surrogate marker for clinical outcomes in multiple sclerosis / Maria Pia Sormani -- Measurement of cerebral atrophy in multiple sclerosis / Ernst-Wilhelm Radue, Kerstin Bendfeldt & Till Sprenger -- Symptomatic therapy for multiple sclerosis / Scott E. Jarvis, Aaron Mackie & Luanne M. Metz -- Neurologic rehabilitation in multiple sclerosis / Susan E. Bennett -- Treatment of pediatric multiple sclerosis / Angelo Ghezzi -- Complementary and alternative treatments / Allen C. Bowling -- Future directions in multiple sclerosis / Anat Achiron -- Index.
  • 2014 Springer
    Banerjee, Ena Ray.
    "Perspectives in Inflammation Biology" outlines detailed studies using preclinical murine models in Inflammation. The book is meant for academicians, industry persons, research scholars and students alike. The detailed perspective for a beginner and the exhaustive methodologies and analyses outlined, for the veteran researcher, makes this book a unique link between someone who is thinking of embarking on a study of inflammation and one who is delving deep into this area of specialization. The book deals with asthma and allergy as specific disease areas of inflammation of the lung, aseptic peritonitis as a disease of systemic inflammation and details how each role player in its pathophysiology has a unique niche of activity. Data acquisition, sequentiality and analyses in context demonstrate how each role player is validated systematically to become a target for drug discovery. Methods and models used in the course of my work and their relevance will demonstrate to the researcher how a study can be developed from an idea. Further into a researcher's ongoing work, this book is meant to stimulate new questions and pave ways for better dissection of a phenomenon. The highlights of this book are the detailed tables tabulating sub species of immune cells, their inflammatory recruitment indices, their translation into tissue-to-tissue traffic of the inflammatory stimulus and the delicate interplay of resident structural cells, cells recruited from circulation, their feedback poiesis in bone marrow, their instruction in the lymphoid organs and tissues as well as the non-cellular mediators synthesized from corresponding genetic instruction. The book shall definitely help students and researchers how a disease can be simplified from its complex ramifications and network of implications and put back into perspective and the whole thing falls into place without an intimate understanding of the mechanism and the compelling circumstances that causes a disease, a drug hunter cannot hope to begin her quest. To find the Achilles heel and effectively neutralize the enemy!
  • 2009 Springer
    Krysko, Dmitri V.; Vandenabeele, Peter.
  • 2012 SpringerLink
    Falasca, Marco.
    Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
  • 2011 Springer Protocols
    McDowell, John M.
    Studying NB-LRR immune receptor localization by agroinfiltration transient expression / Patrick Cournoyer and S.P. Dinesh-Kumar -- Fragment complementation and co-immunoprecipitation assays for understanding R protein structure and function / Peter Moffett -- Purification of resistance protein complexes using a biotinylated affinity (HPB) tag / Yiping Qi and Fumiaki Katagiri -- Biochemical purification of native immune protein complexes / James M. Elmore and Gitta Coaker -- Chromatin immunoprecipitation to identify global targets of WRKY transcription factor family members involved in plant immunity / Mario Roccaro and Imre E. Somssich -- Dose-response to and systemic movement of dexamethasone in the GVG-inducible transgene system in Arabidopsis / Xueqing Geng and David Mackey -- Quantifying alternatively spliced mRNA via capillary electrophoresis / Xue-Cheng Zhang and Walter Gassmann -- Constructing haustorium-specific cDNA libraries from rust fungi / Ann-Maree Catanzariti [and others] -- Microaspiration of esophageal gland cells and cDNA library construction for identifying parasitism genes of plant-parasitic nematodes / Richard S. Hussey, Guozhong Huang, and Rex Allen -- Construction of Pseudomonas syringae pv. tomato DC3000 mutant and polymutant strains / Brian H. Kvitko and Alan Collmer -- A straightforwward protocol for electro-transformation of Phytophthora capsici zoospores / Edgar Huitema, Matthew Smoker, and Sophien Kamoun -- Propagation, storage, and assays with Hyaloperonospora arabidopsidis : a model oomycete pathogen of Arabidopsis / John M. McDowell [and others] -- Assaying effector function in planta using double-barreled particle bombardment / Shiv D. Kale and Brett M. Tyler -- Assays for effector-mediated suppression of programmed cell death in yeast / Yuanchao Wang and Qian Huang -- Purification in effector-target protein complexes via transient expression in Nicotiana benthamiana / Joe Win, Sophien Kamoun, and Alexandrea M.E. Jones -- Imaging fluorescently tagged Phytophthora effector proteins inside infected plant tissue / Petra C. Boevink, Paul R.J. Birch, and Stephen C. Whisson -- Immunolocalization of pathogen effectors / Eric Kemen, Kurt Mendgen, and Ralf T. Voegele -- Laser capture microdissection of nematode feeding cells / Nagabhushana Ithal and Melissa G. Mitchum -- Laser microdissection of plant-fungus interaction sites and isolation of RNA for downstream expression profiling / Divya Chandran, Noriko Inada, and Mary C. Wildermuth -- Global expression profiling of RNA from laser microdissected cells at fungal-plant interaction sites / Divya Chandran, Greg Hather, and Mary C. Wildermuth -- Visualizing cellular dynamics in plant-microbe interactions using fluorescent-tagged proteins / William Underwood, Serry Koh, and Shauna C. Somerville.
  • 2011 Future Med
    Buonaguro, Franco M.
    Plant-derived vaccines : technologies & applications / Franco M. Buonaguro -- Patents and molecular farming / Pascal M.W. Drake & Harry Thangaraj -- In planta production of recombinant and indigenous adjuvants / Antonio Granell, Asun Fernandez-del-Carmen & Diego Orzáez -- Rapid and high-yield production of immunotherapeutic plant-made antibodies / Cristina Capodicasa, Marcello Donini, Maria Elena Villani & Eugenio Benvenuto -- Vaccine peptide display on recombinant tobacco mosaic virus particles / Tatiana V. Komarova, Igor V. Petrunia & Yuri L. Dorokhov -- Plastid transformation as a tool for plant-based production of vaccines and therapeutic proteins / Paolo Lenzi, Nunzia Scotti, Pal Maliga & Teodoro Cardi -- Prophylactic and therapeutic HPV vaccines from plants / Edward P. Rybicki, Colomba Giorgi & Rosella Franconi -- Plant-derived anti-HIV-1 proteins / Nunzia Scotti, Luigi Buonaguro, Maria Lina Tornesello, Teodoro Cardi & Franco Maria Buonaguro -- Plant-based hepatitis B vaccines / Sergei N. Shchelkunov & Galina A. Shchelkunova -- Influenza vaccines : new perspectives from plants / Chiara Lico, Giampaolo Buriani, Floriana Capuano, Eugenio Benvenuto & Selene Baschieri -- Plant-made mucosal vaccines / Rurick K. Salyaev, Maria Manuela Rigano & Natalya I. Rekoslavskaya -- Current status of plant-made veterinary vaccines / Assunta Pelosi, Claire Penney, Huai-Yian Ling & Amanda M. Walmsley.
  • 2012 Future Med
    Rijkers, Ger T.
    Pneumococcal conjugate vaccines / Ger T. Rijkers -- Pneumococcal conjugate vaccines overview / Michael E. Pichichero -- Pneumococcal conjugate vaccines in children / Ingeborg S. Aaberge -- Pneumococcal vaccination in elderly / Ger T. Rijkers -- Pneumococcal conjugate vaccine in immunocompromised individuals / Marta C. Nunes & Shabir A. Madhi -- Pneumococcal conjugate vaccines in developing countries / Ener Cagri Dinleyici -- Current and future guidelines for pneumococcal conjugate vaccination / Elske van Gils, Ger Rijkers & Elisabeth Sanders -- Antibody response to pneumococcal polysaccharide vaccination in patients treated with biologicals / Minke Rab & Ger T. Rijkers -- Index.
  • 2010 Springer
    Dharnidharka, Vikas R.; Green, Michael; Webber, Steven A.
    Introduction / Vikas R. Dharnidharka, Michael Green and Steven Webber -- Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD) / Douglas W. Hanto -- Epidemiology of PTLD / Vikas R. Dharnidharka -- The Biology of Epstein-Barr Virus and Posttransplant Lymphoproliferative Disease / Olivia M. Martinez -- Epstein-Barr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders / Jutta K. Preiksaitis -- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder / Upton D. Allen -- Pathology / Steven H. Swerdlow -- Prognostic Factors for PTLD / Tapan Maniar and Donald Tsai -- Treatment of PTLD / Steven A. Webber -- Prevention of Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation / Michael Green and Marian Michaels -- Organ Specific Issues of PTLD - Kidney / Sophie Caillard -- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients / Jaime Pineda and George V. Mazariegos -- Heart and Lung Transplantation / Silke Wiesmayr and Steven A. Webber -- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT) / Thomas G. Gross -- Research Priorities and Future Directions / Vikas R. Dharnidharka, Michael Green and Steven A. Webber.
  • 2015 Springer
    Shaw, Marc; Wong, Claire.
    This inclusive work presents a comprehensive update on vaccines for the international traveller. In over 21 chapters, written by leading writers in travel medicine from Australia, New Zealand and Singapore, vaccinology for travel is explained in accessible terms with a focus on practical information. An initial introduction to immunology proceeds into common travel-related diseases, and a risk-analysis for acquiring them, followed by vaccine administration techniques and examples of how this knowledge can be applied to the traveller with special risks including children, pregnant women and mass travel. The book also provides a summary of current clinical practice with respect to travel medicine in Australia, New Zealand and Singapore. This straightforward guide to the administration of vaccines for travellers is intended to be the one-stop for the primary healthcare professional needing authoritative practical information speedily. In addition to basic knowledge in vaccinology, guides are offered as to appropriate vaccine recommendations for travel to global regions together with vaccine contents in order to identify any precautions and contraindications. This text presents assessment and management guidelines for common medical presentations to the travel health professional in primary-care health. Easy reference chapters, with practical management parameters for vaccination for travellers, will confidently guide any knowledge acquired permitting self-responsibility in vaccine-preventable disease prevention.
  • 2015 Springer
    Batra, Pete S.; Han, Joseph K.
    Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and paranasal sinuses with symptoms persisting for at least 3 months. The treatment paradigm for CRS includes medical therapy as the cornerstone, coupled with endoscopic sinus surgery in refractory cases. To date, however, no FDA-approved treatments exist for medical treatment of CRS, and most treatment algorithms rely on expert opinion supplemented by available peer-review data. This underscores the need for a comprehensive primer to optimize the care of CRS patients. This book is a detailed compendium on the medical and surgical treatment of CRS, with or without polyposis. Detailed coverage is provided of a wide range of topics, including pathophysiologic mechanisms, medical and surgical management of CRS and its subsets, medical therapy in the pre- and postoperative period, specific medical therapeutic classes currently employed in CRS patients, and optimization of the efficacy of endoscopic sinus surgery for postoperative medical therapy. Each chapter highlights key aspects of specific therapies, including mechanism of action, indications, dosages, side-effects, and available clinical efficacy data, and emphasizes practical management pearls and pitfalls from experts in the field. Operative techniques for endoscopic sinonasal procedures for CRS are also outlined. This book will be a valuable resource for practicing general otolaryngologists, rhinologists, and allergists as well as residents and fellows in training. It will also serve as a reference guide for physician assistants, nurse practitioners, and nurses involved in the care of CRS patients.
  • 2013 Springer
    Jacob, Sharon E.; Herro, Elise M.
    The field of contact dermatitis is potentially frustrating given the complexity of the clinical decision-making process and the effect of false positives and negatives on patient expectations and management. Practical Patch Testing and Chemical Allergens in Contact Dermatitis outlines the most common allergens with practical tips for patch testing in a concise and algorithmic fashion. Children have different needs for patch testing and this handbook describes how to test them safely and manage their disease. Educating patients on how to avoid their irritants and allergens is also key to treatment in all types of contact dermatitis. The authors have incorporated concise reference material on where these chemicals are found and how patients can avoid them. Clinical pearls for patch testing of certain allergens are clearly outlined in this handbook to help providers avoid common pitfalls and reduce the risk of incorrect diagnoses. A frustrating clinical visit and a disappointed patient can potentially be avoided with the use of this book, and thus is is an essential reference for trainees in dermatology and all involved in the management of patients with dermatitis.
  • 2008 Springer
    Aghamohammadi, Asghar; Notarangelo, Luigi; Rezaei, Nima.
  • 2010
    Deal, Emily M.; Arvin, Ann M.; Butcher, Eugene C.; Engleman, Edgar G.; Greenberg, Harry B.; Schneider, David.
    Rotaviruses are the leading cause of severe dehydrating diarrhea in children worldwide. Rotavirus-induced immune responses, especially the T and B cell responses, have been extensively characterized; however, little is known about innate immune mechanisms involved in the control of rotavirus infection. Although increased levels of systemic type I interferon correlate with accelerated resolution of rotavirus disease, multiple rotavirus strains, including rhesus rotavirus (RRV), have been demonstrated to antagonize type I interferon production in a variety of epithelial and fibroblast cell types through several mechanisms, including degradation of multiple interferon regulatory factors by a viral nonstructural protein. Dendritic cells (DCs), a highly specialized subset of professional antigen- presenting cells, play a central role in the initiation of innate and adaptive immunity. Plasmacytoid DCs (pDCs), which secrete the type I interferons, as well as a variety of other cytokines and chemokines, have been documented to have multiple antiviral effects. These studies characterize the primary human pDC response to rotavirus, while elucidating the viral and cellular requirements for this response. Additionally, these studies demonstrate that type I interferon derived from primary pDCs is necessary and sufficient for B cell activation by rotavirus.
  • 2012 Springer
    Pachner, Andrew R.
    Immunology for the Non-immunologist -- Neurology for the Non-neurologist -- Neuroimmunology for the Non-neuroimmunologist -- The Prototypic Neuroimmunological CNS Disease: Multiple Sclerosis, a Precis -- Multiple Sclerosis: Diagnosis -- Multiple Sclerosis Mimics -- Multiple Sclerosis Therapy -- Experimental Models of MS -- Guillain-Barré Syndrome (GBS) and Other Immune-Mediated Neuropathies -- Neuromuscular Neuroimmunological Diseases: Myasthenia Gravis -- The Prototypic Neuroimmunological Muscle Disease: Dermatomyositis -- A Introduction to Neurological Infections: Neuro-infectious Disease as Part of Neuroimmunology -- Neurological Manifestations of Systemic Chronic Inflammatory Disease -- The Neuroimmunology of Cancer: Paraneoplastic Syndromes and Primary CNS Lymphoma -- Neuroimmunology of Degenerative Diseases and Stroke -- Important Rare Neuroimmunological Diseases -- Neuroimmunological Molecules and Translational Medicine -- Neuroimmunological Diagnostic Tests -- Therapy in Neuroimmunological Disease.
  • 2014 ClinicalKey
    Mak, Tak W.; Jett, Bradley D.; Saunders, Mary E.
    Written in the same conversational style as the first edition, Primer to The Immune Response, 2nd edition is a fully updated resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject's fascinating appeal. The figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide addiitonal insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Contains research passages that feature current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.
  • 2005 Springer
    Nijkamp, Franciscus Petrus; Parnham, Michael J.
  • 2011 Springer
    Nijkamp, Franciscus Petrus; Parnham, Michael J.
  • 2012 Springer
    Pietschmann, Peter.
  • 2014 CRCnetBASE
    Alvarez, Susana; Kitazawa, Haruki; Villena, Julio.
    "Written by international experts, this book reviews recent, cutting-edge research on the use of immunoregulatory probiotics (immunobiotics) and their bioactive compounds (immunogenics) to prevent and improve health. Each chapter provides critical insight, reviews current research, discusses future perspective, and stimulates discussion. The book also dicsusses novel applications of immunobiotics such as their use in respiratory infections, regulation of the interaction between inflammation and coagulation as well as their effect on hematopoiesis"--Provided by publisher.
  • v. 1-, 2009- ScienceDirect
  • 2011 Springer
    Chignard, Michel; Vergnolle, Nathalie.
    Also available: Print – 2011
  • 2012 Springer Protocols
    Yan, Qing.
    pt. I. Stress and immunity: biopsychosocial models. The role of psychoneuroimmunology in personalized and systems medicine / Qing Yan -- Psychoneuroimmunology: the experiential dimension / Elling Ulvestad -- Psychosocial job stress and immunity: a systematic review / Akinori Nakata -- Immune cells listen to what stress is saying: neuroendocrine receptors orchestrate immune function / Harlan P. Jone -- Physical activity, stress reduction, and mood: insight into immunological mechanisms / Mark Hamer, Romano Endrighi, and Lydia Poole -- pt. II. Translation of psychoneuroimmunology into personalized medicine: potential biomarkers and clinical implications. Translational implications of inflammatory biomarkers and cytokine networks in psychoneuroimmunology / Qing Yan -- Cytokines as potential biomarkers for Parkinson's disease: a multiplex approach / Darcy Litteljohn and Shawn Hayley -- Exploring the diagnostic potential of immune biomarker coexpression in Gulf War illness / Gordon Broderick, Mary Ann Fletcher, Michael Gallagher, Zachary Barnes, Suzanne D. Vernon, and Nancy G. Klimas -- Neuroimmune mechanisms of depression in heart failure / Jessica A. Jiménez and Paul J. Mills -- A reinterpretation of the Pathogenesis and Cure of Cancer According to the Psychoneuroimmunological Discoveries / Paolo Lissoni -- Aging microglia: relevance to cognition and neural plasticity / Rachel A. Kohman -- Autism spectrum disorders: from immunity to behavior / Milo Careaga and Paul Ashwood -- pt. III. Technologies and models in psychoneuroimmunology studies. Mouse testing methods in psychoneuroimmunology: an overview of how to measure sickness, depressive/anxietal, cognitive, and physical activity behaviors / Jason M. York, Neil A. Blevins, Tracy Baynard, and Gregory G. Freund -- The MRL model: an invaluable tool in studies of autoimmunity-brain interactions / Boris Sakić -- Interleukin-2 and the brain: dissecting central versus peripheral contributions using unique mouse models / John M. Petitto, Danielle Meola, and Zhi Huang -- Psychoneuroimmunology and natural killer cells: the chromium release whole blood assay / Mary Ann Fletcher, Zachary Barnes, Gordon Broderick, and Nancy G. Klimas -- The application of PET imaging in psychoneuroimmunology research / Jonas Hannestad -- The vaccination model in psychoneuroimmunology research: a review / Anna C. Phillips -- Using vaccinations to assess in vivo immune function in psychoneuroimmunology / Victoria E. Burns -- Translational bioinformatics in psychoneuroimmunology: methods and applications / Qing Yan.
  • 2011
    Fathman, John Warner; Negrin, Robert S.; Shizuru, Judith A.; Sunwoo, John B.; Weissman, Irving L.
    Hematopoietic stem cells (HSC) are at the top of hematopoietic hierarchy and give rise to functional effector cells through a succession of increasingly committed downstream progenitor cells. Based upon data obtained from transplantation and in vitro culture experiments we have constructed a model of hematopoietic development by which small numbers of HSCs generate large numbers of mature effector cells through the successive amplification of transiently proliferating progenitor cells downstream of HSCs. HSCs have been extensively characterized based on their cell surface phenotype and functional activities during transplantation assays. Here we describe a marker, CD11a, which allows for the enhanced purification of murine HSCs. We have shown that upregulation of CD11a on HSCs denotes the loss of self-renewal potential, and that CD11a-Slam+CD34-c-kit+Sca1+Lin- are the true HSC. Natural killer (NK) cells develop in the bone marrow and are known to gradually acquire the ability to eliminate infected and malignant cells, yet the cellular stages of NK lineage commitment and maturation are incompletely understood. Using 12-color flow cytometry, we identified a novel NK-committed progenitor (pre-NKP) that is a developmental intermediate between the upstream common lymphoid progenitor (CLP) and the downstream NKP, previously assumed to represent the first stage of NK lineage commitment. Taken together, our data provide a high-resolution in vivo analysis of the earliest steps of NK cell commitment and maturation.
  • 2016 Springer
    Johansen, J. D.; Lepoittevin, J.-P; Thyssen, Jacob P.
    Immunology: A Quick Guide -- Clinical Features of Contact Dermatitis -- Patch Testing: Essentials -- Patch Testing with Own Products -- Allergic Contact Dermatitis: Clinical Relevance and Exposure Assessment of Allergens -- Irritant Contact Dermatitis: Diagnosis and Risk Factors -- Photoreactions and Testing -- Protein Contact Dermatitis and Testing -- Occupational Contact Dermatitis -- Contact Allergy in Children -- Main Allergen Groups: Metals -- Fragrances -- Preservatives. Allergens in Various Products: Textiles and Hair Dyes -- Dental Materials -- Shoes/Gloves -- Glues -- Metalworking Fluids -- Plants -- Cosmetics -- Workers Protection: Gloves, Creams -- Overview of Allergens.
  • 2011 ClinicalKey
    Rosenthal, Ken S.; Tan, Michael J.
    "Get the most from your study time, and experience a realistic USMLE simulation with Rapid Review Microbiology and Immunology, 3rd Edition, by Drs. Ken S. Rosenthal and Michael J. Tan. This new reference in the highly rated Rapid Review Series is formatted as a bulleted outline with photographs, tables and figures that address all the microbiology and immunology information you need to know for the USMLE. And with Student Consult functionality, you can become familiar with the look and feel of the actual exam by taking a timed or a practice test online that includes 400 USMLE-style questions."--Publisher's website.
  • 2014 Wellcome Trust
    Overy, Caroline; Tansey, E. M.
  • 2010
    Gibbs, Kenneth Demire; Levy, Ronald; Martinez, Olivia; Nolan, Garry P.; Weissman, Irving L.
    Hematopoiesis is organized as a cellular hierarchy in which long-term self-renewing hematopoietic stem cells (HSC) give rise to all lineages of blood cells for the lifetime of an organism. Following the prospective isolation of mouse HSC in the late 1980s, research over the past two decades has focused on refining the phenotypic compartment where HSC reside, and identifying the numerous cell intrinsic and extrinsic mechanisms important for their maintenance. Many of these pathways are misappropriated in hematopoietic malignancies such as leukemia. It has been proposed that like normal hematopoiesis, leukemia is organized as a cellular hierarchy in which a leukemic stem cell population (LSC) is uniquely able to self-renew and gives rise to the heterogeneous lineages of cells that compose the tumor. This thesis will cover the mechanisms regulating the behavior of normal hematopoietic stem cells and leukemic stem cells. First, phospho-specific flow cytometry was utilized to define the responsiveness of human HSC to cytokine stimulation. This direct biochemical analysis demonstrated that HSC respond directly and rapidly to a broader number of direct stimuli in vitro and in vivo than previously appreciated. This included Granulocyte Colony Stimulating Factor (G-CSF), a cytokine used clinically to mobilize HSC to the peripheral blood prior to bone marrow transplantation. The direct HSC response to G-CSF is shown to affect the behavior of the HSC pool in vitro (causing cell cycle entry and increased proliferation), and in vivo (negatively regulating active hematopoiesis in the short-term). Thus, it is proposed that cytokines, long known to impact the function of mature lineage cells, also are important for the steady-state regulation of HSC activity. Next, two mouse models of AML were utilized to determine the mechanisms important for regulation of LSC activity. It is demonstrated that the catalytic p110[lower case delta] subunit of Phosphoinositide 3-kinase (PI3K), which is constitutively activated and drives proliferation in human AML blasts, is dispensable for de novo leukemogenesis and LSC activity in AML driven by retroviral transfer of MLL-AF9 or HoxA9-Meis1 (H9M) oncogenes into early hematopoietic progenitors. Finally, the LSC in H9M AML are identified. Surprisingly, multiple phenotypic compartments were equally enriched for LSC activity. This was also the case when LSC activity in MLL-AF9 driven AML was assessed. Putative genetic LSC maintenance signatures for each model were also identified. There was both overlap and stark contrast in cell surface phenotypes of the LSC-enriched compartments and the genetic LSC maintenance signatures in these closely related leukemias. These data suggest that like normal hematopoiesis, a hierarchy does exist in which self-renewing cells give rise to terminally differentiated progeny. However, unlike HSC activity, which can be isolated to a single compartment by cell surface phenotype that is commonly regulated between individuals, LSC activity is a cell state that can be independent of surface phenotype and with context-specific regulatory mechanisms.
  • 2010
    Rios, Eon Joseph; Galli, Stephen J.; Meyer, Tobias; Nusse, Roeland; Utz, Paul J.
    Cell surface receptor regulation maintains proper responses to external signals and disregulation of receptors can have drastic effects. We found that RabGEF1, a guanine exchange factor (GEF) for the endocytic regulating small GTPase Rab5, regulates IgE+antigen (Ag)-induced Ras signaling in mast cells and skin homeostasis in vivo. To further understand RabGEF1's role in mast cell function we investigated if RabGEF1 generally regulates mast cell signaling by examining a number of modes of mast cell activation. Like IgE+Ag stimulation, RabGEF1 deficient (-/-) mast cells demonstrated enhanced activation after exposure to stem cell factor (SCF), the ligand for the receptor tyrosine kinase c-kit. Enhanced responses correlated with delayed c-kit and IgE receptor (FcεRI) internalization suggesting a proximal role of RabGEF1 in regulating mast cell signaling events. To dissect the roles of RabGEF1 and its domains in regulating mast cell biology we lentivirally expressed a panel of RabGEF1 mutants in RabGEF1-/- mast cells. We found that RabGEF1 (1) harbors ubiquitin (Ub) ligase activity within an N-terminal A20 zinc finger domain, (2) binds to Ub and localizes to membranes through amino acids 1-150, (3) interacts with Rabaptin-5, a Rab5 effector, through a C-terminal coiled coil (CC) domain and, (4) activates Rab5 with a central VPS9 domain. Despite containing a number of domains, only the VPS9 was crucial to restore wildtype activation of RabGEF1-/- cells after IgE+Ag stimulation. Moreover, lack of the VPS9 or CC domain diminished Rabaptin-5 levels and reduced surface FcεRI and β1 expression on mast cells suggesting that these domains are important for receptor homeostasis. Using shRNA knockdown of Rabaptin-5 we identified a novel role for Rabaptin-5 in maintaining FcεRI and β1 surface expression by increasing surface stability and receptor half-life. The reduced FcεRI and β1 surface levels in Rabaptin-5 deficient cells attenuated sensitivity to antigen induced adhesion, migration, and cytokine production in these cells. Despite Rabaptin-5's in vitro documented role as a Rab5 effector, Rab5 dependant processes (i.e., receptor internalization or endosome fusion) were unaffected by Rabaptin-5 deficiency and challenge the current thoughts of Rab5 processes in intact cells. These data show the importance of receptor trafficking in regulating mast cell activation.
  • 2010
    Howitt, Michael R.; Amieva, M. R.; Falkow, Stanley; Monack, Denise M.; Schoolnik, Gary K.; Spormann, Alfred M.
    Microbes can colonize harsh and dynamic environments. Often, this ability depends on rapid responses through directed motility. Members of the Epsilon proteobacteria are found in many 'extreme' environments, including the human stomach. We discovered that Helicobacter pylori establish bacterial colonies deep in the gastric glands, and identified a novel protein, ChePep, necessary to colonize this niche. By tracking the movement of single bacteria we found that mutants lacking ChePep cannot control the rotation of their flagella and swim with abnormally frequent reversals and even sustain bursts of movement backwards. Genetic experiments show that ChePep regulates flagellar rotation through the chemotaxis signaling system. By examining H. pylori within a microscopic pH gradient, we determined that ChePep is critical for normal chemotactic behavior. We expressed ChePep from the zoonotic pathogen Campylobacter jejuni, and the deep sea hydrothermal vent inhabitant Caminibacter mediatlanticus in H. pylori and found that ChePep is functionally conserved across the [epsilon]-proteobacteria. ChePep represents a new family of chemotaxis regulators unique to the [epsilon]-proteobacteria, and illustrates the differing strategies that microbes have evolved to control motility.
  • 2014 Springer Protocols
    Mion, Francesca; Vitale, Gaetano.
  • 2010
    Liu, Gwen; Blau, Helen M.; Chen, Chang-Zheng; Fire, Andrew Z.; Sarnow, P.
    MicroRNA (miRNA) genes, which encode an abundant class of ~22-nucleotide (nt), evolutionarily conserved small RNAs, control a fundamental layer of genetic programs at the post-transcriptional level. However, little is known about how the activity of miRNA genes is regulated and how the regulatory information controlling their activity is encoded. Interestingly, mature miRNAs can often be classified into large families consisting of members with identical seeds (nucleotides 2 through 8 of the mature miRNAs) and highly homologous ~22-nt mature miRNA sequences, but with divergent sequences and structural elements beyond their mature miRNAs. Here we investigated whether members of a miRNA gene family that encode identical or nearly identical mature miRNAs are functionally interchangeable in vivo and if not, why? We compare the activities of the mir-181 gene family in promoting double positive T cell development and show that miRNA genes that encode identical to nearly identical mature miRNAs can have distinct activities. The differences in activity between mir-181a-1 and mir-181c are largely determined by their unique primary/precursor-miRNA (pri/pre-miRNA) loop nucleotides, and the differences in activity between mir-181a-1 and mir-181b-1 are determined by both the pri/pre-miRNA loop and stem. Furthermore, the organization of mir-181a-1/b-1 in a cluster is important for its full activity. We also show that mir-181 family members can differentially regulate target genes quantitatively, and that some target genes can be upregulated. Taken together, we have demonstrated that regulatory information encoded in a miRNA gene beyond the mature miRNA plays a critical role in controlling the activity of the miRNA gene, suggesting that miRNA family members could have evolved different functions through their divergent miRNA gene sequences and structural elements beyond their mature miRNAs. Although, proteins may have evolved to recognize the structural and sequence elements of the pri/pre-miRNAs, we suggest that the regulatory information encoded in the structured pri/pre-miRNA may be directly interpreted through target and pri/pre-miRNA interactions.
  • 2008 Springer
    Jiang, Shuiping.
  • 2005 Springer
    Akbar, Arne N.; Taams, Leonie; Wauben, Marca H. M.
    Also available: Print – 2005
  • 2006 ScienceDirect
    Branch, D. Ware; Lockshin, Michael.
  • 2013 Springer
    Bonavida, Benjamin.
    Introduction and generation of chimeric and humanized mAbs -- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment -- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs -- Mechanisms of antibodies-mediated responses, in vitro and in vivo -- Molecular Pathways -- Molecular Signatures -- Identification of resistance targets for intervention -- Various chemicals that can sensitize resistant tumor cells -- Other mAbs -- Proteasome inhibitors -- Divalent mAbs -- Antibodies coupled to chemical inhibitors -- Antibodies coupled to cytokines -- Nanoparticles with mAbs.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.
    Also available: Print – 2015
  • 2011
    Leong, Hwei Xian; Butcher, Eugene C.; Contag, Christopher H.; Engleman, Edgar G.; Negrin, Robert S.
    In the Adenomatous Polyposis Coli Multiple intestinal neoplasia (APCMin/+) mouse model of Familial Adenomatous Polyposis (FAP), T helper 17 (Th17) cells mediate tumor-promoting intestinal inflammation, but the underlying cause of inflammation is unknown. We find that in contrast to wild type lamina propria dendritic cells (LPDCs), which maintain intestinal tolerance by inducing TReg formation, APCMin/+ LPDCs instead induce Th17 formation. The reprogramming of LPDCs is due to a local deficit of the vitamin A metabolite, retinoic acid (RA), which results from insufficient synthesis and excessive breakdown of RA by gut associated Raldh and CYP enzymes, respectively. Exposure of APCMin/+ LPDCs to RA in vitro neutralizes their inflammatory phenotype. Treatment of mice with Liarozole, a CYP inhibitor, restores intestinal RA, eliminates Th17 inflammation and markedly reduces adenoma formation, whereas a vitamin A-deficient diet exacerbates disease. Elevated IL-17 and dysregulated vitamin A metabolism were also observed in FAP adenomas, suggesting that the same mechanism responsible for tumor-promoting intestinal inflammation in APCMin/+ mice applies to humans.
  • 2010 CRCnetBASE
    Rea, William J.; Patel, Kalpana.
    Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.
  • 2015 CRCnetBASE
    Rea, William J.; Patel, Kalpana.
  • 2014 (13th ed.) AccessMedicine
    12th ed., 2012 AccessMedicine
    Levinson, Warren.
    Also available: Print – 2006-<2014>
  • 2012 Springer
    Mantis, Nicholas J.
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • 2008 Springer
    Paddison, Patrick J.; Vogt, Peter K.
    RNA interference in mammalian cell systems / Patrick J. Paddison -- RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard -- Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi ... [et al.] -- Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz -- The mechanism of RNase III action: how dicer dices / Xinhua Ji -- MicroRNA metabolism in plants / Xuemei Chen -- Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron -- RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire -- A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin -- RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris -- RNA silencing in mammalian oocytes and early embryos / Petr Svoboda -- Identifying human microRNAs / Isaac Bentwich.
    Also available: Print – 2008
  • 2005 Springer
    Griffin, Diane E.
    Mechanisms of apoptosis during reovirus infection / P. Clarke ... [et al.] -- Poliovirus, pathogenesis of poliomyelitis, and apoptosis / B. Blondel ... [et al.] -- Neuronal cell death in alphavirus encephalomyelitis / D. E. Griffin -- HSV-induced apoptosis in herpes encephalitis / L. Aurelian -- The role of apoptosis in defense against baculovirus infection in insects / R. J. Clem -- The role of host cell death in Salmonella infections / D. G. Guiney -- Role of macrophage apoptosis in the pathogenesis of Yersinia / Y. Zhang, J. B. Bliska -- Entamoeba histolytica activates host cell caspases during contact-dependent cell killing / D. R. Boettner, W. A. Petri -- Interactions between malaria and mosquitoes : the role of apoptosis in parasite establishment and vector response to infection / H. Hurd, V. Carter, A. Nacer -- Apoptosis and its modulation during infection with Toxoplasma gondii : molecular mechanisms and role in pathogenesis / C. G. K. Luder, U. Gross -- Modulation of the immune response in the nervous system by rabies virus / M. Lafon -- Apoptotic cells at the crossroads of tolerance and immunity / M. Skoberne ... [et al.].
    Also available: Print – 2005
  • 2011
    Swanson, Christina D'Aura; Fathman, C. Garrison; Robinson, William H.; Sobel, Raymond; Steinman, Lawrence.
    Rheumatoid arthritis (RA) is an autoimmune synovitis affecting approximately 0.5% of the population worldwide. In addition to T cells, B cells and macrophages, cells such as synovial fibroblasts promote inflammation in the synovium by producing cytokines and chemokines. At the same time, neovascularization provides nutrients and oxygen to the growing pannus and increased osteoclastogenesis causes bone destruction. RA serum and synovial fluid contains increased concentrations of epidermal growth factor receptor (EGFR) ligands; and synovial fibroblasts and endothelial cells in RA synovium express EGFR. Thus, we hypothesized that a specific EGFR tyrosine kinase inhibitor, erlotinib, would ameliorate murine collagen-induced arthritis (CIA). Erlotinib is currently prescribed for the treatment of non-small cell lung cancer and pancreatic cancer. Here, we demonstrate that erlotinib reduces the severity of established murine CIA and investigated the mechanisms of this inhibition. Erlotinib reduced: 1) EGF-induced proliferation of fibroblasts and human umbilical vein endothelial cells (HUVEC), 2) EGF-induced production of IL-8 and vascular endothelial cell growth factor (VEGF) by fibroblasts, and 3) the development of osteoclasts from bone marrow cells. Together, these findings suggest that EGFR plays a central role in the pathogenesis of RA and that EGFR inhibition may provide benefit in the treatment of RA.
  • 2010
    Vleck, Susan Elizabeth; Arvin, Ann M.; Glenn, Jeffrey S.; Greenberg, Harry B.; Kirkegaard, Karla.
    Glycoprotein H (gH) plays an essential role in virus binding, entry and fusion of the Herpesviridae. Varicella-zoster virus (VZV) is an important human pathogen that causes varicella (chicken pox) and herpes zoster (shingles). VZV gH function has not be analyzed in depth. gH function was demonstrated to be important for VZV pathogenesis in skin xenografts in vivo by administration of anti-gH mAb 206, a conformation dependent neutralizing antibody. Antibody administration prevented infection in 42% of skin xenografts, and reduced virus replication and lesion formation in the remaining skin xenografts. Antibody binding to gH altered gH localization following endocytosis, preventing gH trafficking to the trans-Golgi network for virus secondary envelopment. Antibody binding to gH within the virus envelope resulted in internalization of virus particles, possibly for targeted degradation. Deletion of ORF 37, which encodes gH, demonstrated that gH was essential for VZV pathogenesis. Mutational analysis demonstrated that the N-terminus of the protein formed a structural epitope required for efficient VZV pathogenesis in vivo. Several neutralizing anti-gH antibodies target this epitope. A region of the C-terminus was required for VZV pathogenesis, and for efficient virus-induced cell-cell fusion. Predicted α-helices that might act as heptad repeats or fusion peptides were also required for gH function and VZV pathogenesis. Cysteine residues were important for gH maturation and transport, and possibly for correct expression of gH on the cell surface. Altogether, these studies demonstrate the importance of structural and functional domains for gH-dependent fusion and VZV pathogenesis.
  • 2010
    Wai, Lu-En; Jones, Patricia; Krams, Sheri M.; Negrin, Robert S.; Parham, P.
    Natural killer (NK) cells are an important component of the innate immune system. NK cells have cytotoxic and cytokine-producing abilities, and are known for their anti-tumor and anti-viral roles. On the other hand, the role of NK cells in solid organ transplantation is not clear. Our studies and others have shown that NK cells infiltrate allografts and NK cell depletion prevents graft rejection. We further described that NK cell depletion prevents tolerance induction in a rat liver transplant model of spontaneous tolerance. NK cell functions are determined by a balance of signals transmitted through their inhibitory and activating receptors. We showed that distinct NK activating receptors - NKp46, NKp30 and NKG2D, mediate NK cell interactions with dendritic cells (DC) and hepatoma tumor cells in vitro, presenting a way to perturb NK-DC interactions while retaining tumor responsiveness. Finally, initial experiments with NKG2D knockout mice showed that NKG2D deficiency combined with costimulation blockade prolongs allograft survival, suggesting that NKG2D inhibition may improve future costimulation blockade therapies. Importantly, current immunosuppressive drugs used to control graft rejection have differential effects on NK cell function. Thus understanding the interactions NK cells have with the graft and other immune cells in the context of transplantation is essential for improving transplantation therapeutics.
  • 2011
    Crespo Diaz, Oliver; Fathman, C. Garrison; Robinson, William H.; Steinman, Lawrence; Utz, Paul J.
    Multiple Sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system characterized by demyelination and variable axonal loss. Tyrosine kinases play a central role in the activation of signal transduction pathways and cellular responses that mediate the pathogenesis of MS. Imatinib mesylate (imatinib), sorafenib, and GW2580 are tyrosine kinase inhibitors (TKIs) developed to treat diverse types of cancers. This thesis demonstrates that Imatnib and Sorafenib, two PDGFR inhibitors and GW2580, a specific Fms inhibitor, can prevent and treat MOG-induced experimental autoimmune encephalomyelitis (EAE). My observations suggest that the c-Fms and PDGFR tyrosine kinase signaling pathways play a central role in the pathogenesis of EAE and MS. I believe that c-Fms primes macrophages to produce TNF and that PDGFR induces astrocytes to proliferate, which are cellular responses contributing to autoimmune demyelination in multiple sclerosis. Chapter 1 provides a general introduction to MS and EAE and the role different cell types of the immune system play in disease pathogenesis, paying particular attention to the role of macrophages and astrocytes. Chapter 2 describes in further detail the different functions mediated by MCSF in macrophages and how these are tied to the pathology of MS. In this chapter, the experiments performed to determine whether c-Fms inhibition using tyrosine kinase inhibitors could have an effect on pathogenic macrophage functions are described. Chapter 3 focuses on the immune functions of astrocytes, emphasizing those believed to be mediated by PDGFR signaling, and the experiments performed to test the effects of tyrosine kinase inhibitors on PDGFR-mediated astrocyte functions. Chapter 4 concludes with a discussion of the results and future directions for the use of tyrosine kinase inhibitors for the screening of potential targets involved in the pathogenesis of autoimmune diseases.
  • 2001 Ovid
    Austen, K. Frank; Samter, Max.
    v. 1. Recognition : innate and adaptive immunity -- Effector mechanisms : innate and adaptive -- Primary immunodeficiencies -- Proliferation disorders of immunologic cells -- v. 2. Systemic diseases -- Organ-specific diseases -- Allergic diseases -- Evasion, activation and ineffective immunity -- Transplantation -- Therapeutic immunology.
    Also available: Print – v. 1-2, 2001.
  • 2012 Springer
    López-Larrea, Carlos.
    The origin of the bacterial immune response / Jesús Martínez Borra, Segundo González, and Carlos López Larrea -- The evolution of self during the transition to multicellularity / Aurora M. Nedelcu -- Glyconectin glycans as the self assembling nano-molecular-velcrosystem mediating self-nonself recognition and adhesion implicated in evolution of multicellularity / Gradimir N. Misevic, Nikola Misevic, and Octavian Popescu -- Neglected biological features in cnidarians self-nonself recognition / Baruch Rinkevich -- Intracellular inflammatory sensors for foreign invaders and substances of self-origin / Nao Jounai, Kouji Kobiyama, and Fumihiko Takeshita -- Nonself perception in plant innate immunity / Ian A. Dubery, Natasha M. Sanabria, and Ju Chi Huang -- How did flowering plants learn to avoid blind date mistakes? : self-incompatibility in plants and comparisons with nonself rejection in the immune response / Philip J. Kear and Bruce McClure -- Signaling pathways that regulate life and cell death : evolution of apoptosis in the context of self-defense / Cristina Muñoz Pinedo -- Sensing necrotic cells / Yasunobu Miyake and Sho Yamasaki -- Sensing endoplasmic reticulum stress / Vipul M. Parmar and Martin Schröder -- Autophagy and self-defense / Jesús Martínez-Borra and Carlos López-Larrea -- Viruses and host evolution : virus-mediated self identity / Louis Villarreal -- The evolution of adaptive immunity / Nadia Danilova -- Epigenetic code and self-identity / Vincanzo Calvanese, Ester Lara and Mario F. Fraga -- Viral immunomodulatory proteins : usurping host genes as a survival strategy / Pablo Engel and Ana Angulo -- The emergence of the major histocompatibility complex / Jesús Martínez-Borra and Carlos López-Larrea -- MHC signaling during social communication / James S. Ruff ... [et al.].
    Also available: Print – 2012
  • 2010 Springer
    Klein, Sabra L.; Roberts, Craig W.
    Sex differences in susceptibility to infection : an evolutionary perspective / Marlene Zuk and Andrew M. Stoehr -- Effects of sex steroids on innate and adaptive immunity / S. Ansar Ahmed, Ebru Karpuzoglu, and Deena Khan -- Sex steroid receptors in immune cells / Susan Kovats, Esther Carreras, and Hemant Agrawal -- Sex differences in susceptibility to viral infection / Sabra L. Klein and Sally Huber -- Sex differences in innate immune responses to bacterial pathogens / Jennifer A. Rettew, Ian Marriott, and Yvette M. Huet -- Sex hormones and regulation of host responses against parasites / James Alexander ... [et al.] -- Sex differences in parasitic infections : beyond the dogma of female-biased resistance / Galileo Escobedo, Marco A. De León, and Jorge Morale-Montor -- Progesterone, pregnancy, and innate immunity / Julia Szekeres-Bartho and Beata Polgar -- Pregnancy and susceptibility to parasites / Fiona L. Henriquez, Fiona M. Menzies, and Craig W. Roberts -- Sex steroids and risk of female genital tract infection / Patti Gravitt and Khalil Ghanem -- Sex, pregnancy, and measles / Allison C. Brown and William J. Moss -- Epilogue : challenges for the future / Craig W. Roberts and Sabra L. Klein.
  • 2002 Karger
    Altman, Amnon.
    Machine generated contents note: 1 Regulation of SignalTransduction by the Fcy Receptor Family -- Members and Their Involvement in Autoimmunity -- Coggeshall, K.M. (Oklahoma City, Okla.) -- 30 The Role ofTNF/TNFR in Organ-Specific and Systemic -- Autoimmunity: Implications for the Design of Optimized 'Anti-TNF' -- Therapies -- Kollias, G.; Kontoyiannis, D.; Douni, E.; Kassiotis, G. (Vari) -- 51 CD40 Signaling and Autoimmunity -- Cheng, G. (Los Angeles, Calif.); Schoenberger, S.P. (San Diego, Calif.) -- 62 TGF-j: Receptors, Signaling Pathways and Autoimmunity -- Chen, W; Wahl, S.M. (Bethesda, Md.) -- 92 lnterleukin-2 Signaling and the Maintenance of Self-Tolerance -- Nelson, B.H. (Seattle, Wash.) -- 113 Role of the B7-CD28/CTLA-4 Pathway in Autoimmune Disease -- Chang, T.T.; Kuchroo, VK.; Sharpe, A.H. (Boston, Mass.) -- 131 AbnormalT Lymphocyte Signal Transduction in Systemic Lupus -- Erythematosus -- Kammer, G.M. (Winston-Salem, N.C.); Tsokos, G.C. -- (Bethesda, Md./Silver Spring, Md.) -- 151 Lyn/CD22/SHP-1 and Their Importance in Autoimmunity -- Blasioli, J.; Goodnow, C.C. (Canberra) -- 161 Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases -- Fang, N.; Fang, D.; Wang, H.-Y.; Altman, A.; Liu, Y.-C. (San Diego, Calif.) -- 176 Keeping theT-Cell Immune Response in Balance: Role of Protein -- Tyrosine Phosphatases in Autoimmunity -- Mustelin, T. (La Jolla, Calif.) -- 191 Author Index -- 192 Subject Index.
  • 2012 Springer Protocols
    Muyldermans, Serge; Saerens, Dirk.
    From whole monoclonal antibodies to single domain antibodies : think small / Jean-Luc Teillaud -- Introduction to heavy chain antibodies and derived nanobodies / Cecile Vincke and Serge Muyldermans -- Overview and discovery of IgNARs and generation of VNARs / Stewart D. Nuttall -- Creation of the large and highly functional synthetic repertoire of human VH and Vk domain antibodies / Olga Ignatovich [and others] -- Preparation of a naive library of camelid single domain antibodies / Aurelien Olichon and Ario de Marco -- Selection by phage display of single domain antibodies specific to antigens in their native conformation / Peter Verheesen and Toon Laeremans -- Semiautomated panning of naive camelidae libraries and selection of single-domain antibodies against peptide antigens / Jyothi Kumaran, C. Roger MacKenzie, and Mehdi Arbabi-Ghahroudi -- Pichia surface display : a tool for screening single domain antibodies / Kristof De Schutter and Nico Callewaert -- Bacterial two hybrid : a versatile one-step intracellular selection method / Mireille Pellis, Serge Muyldermans, and Cecile Vincke -- Intracellular antibody capture (IAC) methods for single domain antibodies / Tomoyuki Tanaka and Terence H. Rabbitts -- Selection of functional single domain antibody fragments for interfering with protein-protein interactions inside cells : a 'one plasmid' mammalian two-hybrid system / Tomoyuki Tanaka and Terence H. Rabbitts -- Cell-free selection of domain antibodies by in vitro compartmentalization / Armin Sepp and Andrew Griffiths -- Selection of VHHs under application conditions / Edward Dolk, Theo Verrips, and Hans de Haard -- Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies / Greg Hussack [and others] -- Selection of VHH antibody fragments that recognize different Ab depositions using complex immune libraries / Rinse Klooster, Kim S. Rutgers, and Silvere M. van der Maarel -- Expression of single-domain antibodies in bacterial systems / Toya Nath Baral and Mehdi Arbabi-Ghahroudi -- Expression of VHHs in Saccharomyces cerevisiae / Andrea Gorlani, Hans de Haard, and Theo Verrips -- Stable expression of chimeric heavy chain antibodies in CHO cells / Vishal Agrawal [and others] -- Production of Camel-Like Antibodies in Plants / Sylvie De Buck [and others] -- Selecting and purifying autonomous human variable heavy (VH) domains / Raffi Tonikian and Sachdev S. Sidhu -- Solubility and stability engineering of human VH domains / Dae Young Kim, Wen Ding, and Jamshid Tanha -- Improvement of proteolytic stability through in silico engineering / Lucy Rutten, Hans de Haard, and Theo Verrips -- Selection of human VH single domains with improved biophysical properties by phage display / Kip Dudgeon [and others] -- Improvement of single domain antibody stability by disulfide bond introduction / Yoshihisa Hagihara and Dirk Saerens -- Characterization of single-domain antibodies with an engineered disulfide bond / Greg Hussack, C. Roger MacKenzie, and Jamshid Tanha -- Affinity maturation of single-domain antibodies by yeast surface display / Akiko Koide and Shohei Koide -- Multivalent display of single-domain antibodies / Jianbing Zhang and C. Roger MacKenzie -- Methods for determining the PK parameters of AlbudAbs[TM] and of long serum half-life drugs made using the AlbudAb[TM] technology / Daniel Rycroft and Lucy J. Holt -- Fluorescent protein specific nanotraps to study protein-protein interactions and histone-tail peptide binding / Garwin Pichler, Heinrich Leonhardt, and Ulrich Rothbauer -- Site-specific labeling of his-tagged nanobodies with 99mTc : a practical guide / Catarina Xavier [and others] -- Nanobody-based chromatin immunoprecipitation / Trong Nguyen Duc [and others] -- User-friendly expression plasmids enable the fusion of VHHs to application-specific tags / Ario de Marco -- Application of single-domain antibodies in tumor histochemistry / Kien T. Maik and C. Roger MacKenzie -- Nanobodies as structural probes of protein misfolding and fibril formation / Erwin De Genst and Christopher M. Dobson -- Molecular imaging using nanobodies : a case study / Nick Devoogdt [and others] -- Case study on live cell apoptosis-assay using lamin-chromobody cell-lines for high-content analysis / Kourosh Zolghadr [and others].
  • 2010
    O'Gorman, William Edward; Chen, Chang-Zheng; Davis, Mark M.; Engleman, Edgar G.; Nolan, Garry P.
    Cytokines are essential in the orchestration of effective innate and adaptive immune responses. Immunologists have focused extensively on identifying cytokines, and the cells that produce cytokines, yet there is still little understanding of the complex dynamics that govern cytokine responses in vivo during infection. Chapter 1 provides a general introduction to the cytokine signaling induced by innate and adaptive immune responses. Emphasis is placed on the activation of the signal transducers and activator of transcription (STAT) family of transcription factors by numerous cytokines because monitoring of STAT activation is a sensitive biochemical marker of the cytokine response. Chapter 2 describes the in vivo innate inflammatory response to poxvirus infection. Chapters 3 deals with adaptive immunity and specifically the cytokine responses elicited in vivo by antigen specific T cell activation. Chapter 2 presents experiments demonstrating that early after in vivo exposure to various microbe-associated molecular patterns, STAT1 and STAT3 activation is potently induced in splenic dendritic cells and T cells. Mice with targeted gene deletions were used to identify toll-like receptors (TLRs), interferons, and interleukin-6 (IL-6) as necessary for early STAT activation. These experiments with reductionist microbial ligands demonstrated the feasibility of analyzing the cytokine response to infection with an intact pathogen in vivo. Chapter 2 goes on to describe the innate cytokine response to viral infection in experiments comparing the immune response to two closely related poxviruses: vaccinia and ectromelia (mousepox). Early and robust STAT1 and STAT3 activation was found to strongly correlate with survival of poxvirus infection. In addition, different modes of innate immune recognition distinguished vaccinia from ectromelia infection with toll-like receptor 2 (TLR2) activation being unique to immune recognition of vaccinia and not of ectromelia. These results suggest that different modes of early innate immune recognition could play an essential role in the containment of poxvirus infections and underlie the strict host species specificity of poxviruses. Chapter 3 deals with the paracrine cytokine responses elicited by antigen specific T cell activation in vivo. Using a T cell receptor (TCR) transgenic model we found profound and sustained activation of STAT5 in the Foxp3+ T regulatory cells (T regs) of mice immunized with a model peptide antigen after the adoptive transfer of antigen specific T cells. STAT5 activation in T regulatory cells was found to be interleukin-2 (IL-2) dependent and IL-2 signals elicited T regulatory cell proliferation and enhanced suppressive functions. Infection with vaccinia virus yielded a similar pattern of STAT5 activation in T regulatory cells, and STAT5 signaling was found to be even more potent under conditions of preexisting immune memory. These experiments revealed that antigen specific T-cell activation is intrinsically linked via paracrine IL-2 production to the activation of the polyclonal T reg repertoire, a response mechanism that could prevent autoimmunity. Chapter 3 also describes the regulation of autocrine IL-2 signaling during antigen specific T cell activation. Surprisingly, following TCR stimulation in vivo DO11 T cells did not display potent STAT5 activation even though these cells produced IL-2 and expressed the high affinity IL-2 coreceptor CD25. Only upon secondary TCR stimulation was robust autocrine IL-2 dependent STAT5 activation observed. Overall, these experiments demonstrate the nuances of IL-2/STAT5 signaling across numerous innate and adaptive cells populations revealing that in vivo T regulatory cells are extremely sensitive to antigen specific T cell activation. Targeting IL-2 signals specifically to antigen specific T cells while blocking IL-2 activation of T regs could enhance the efficacy of vaccination.
  • 2012 Springer
    Moutsopoulos, H. M.; Ramos-Casals, Manuel; Stone, John H.
  • 2011 Springer
    Fox, Carla M.; Fox, Robert I.
    Introduction -- A Note from Sweden: Recollection of Henrik Sjögren -- Myths, Pearls, and Tips Regarding Sjögren's Syndrome -- Providing Information to Referring Physicians and Patients -- Current Concepts on Classification Criteria and Disease Status Indexes in Sjögren's Syndrome -- Histopathology and Glandular Biopsies in Sjögren's Syndrome -- Imaging Technology in Sjögren's Syndrome: Non-invasive Evaluation of the Salivary Glands -- Genomics and Viruses in Sjögren's Syndrome -- Autoantibodies and Autoantigens in Sjögren's Syndrome -- B-cell Epitopes of Sjögren's Syndrome-Related Autoantigens Ro/SSA and La/SSB -- Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function -- Overview of Management of Dry Eye Associated with Sjögren's Syndrome -- Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjögren's Syndrome -- Oral and Dental Manifestations of Sjögren's Syndrome: Current Approaches to Diagnostics and Therapy -- Etiology and Pathogenesis of Sjögren's Syndrome with Special Emphasis on the Salivary Glands -- Otolaryngologic Manifestations of Sjögren's Syndrome -- Extraglandular Manifestations of Sjögren's Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations -- Therapy of Dermatologic, Renal, Cardiovascular, Pulmonary, Gynecologic, Gastro-enterologic, Urologic and Fibromyalgia Manifestations Including Special Considerations at the Time of Surgery -- Current Treatment of Extraglandular Manifestations with Disease-Modifying and Immunosuppressive Agents -- Lymphoproliferation and Lymphoma in Sjögren's Syndrome -- Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjögren's Syndrome -- The Neurological Manifestations of Sjögren's Syndrome: Diagnosis and Treatment -- New Approaches for the Management of Dry Mouth in Sjögren's Syndrome in Japan -- New Approaches for the Management of Dry Mouth and Dry Eye in Sjögren's Syndrome in Japan Dry Eye Part -- Sjögren's Syndrome in Australia: Clinical Practice and Research -- Primary Sjögren's Syndrome: Report from India -- Sjögren's Syndrome in China -- Sjögren's Syndrome in China -- Sjögren's Syndrome in Israel: A Scientific Point of View -- Looking into the Future-The EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjögren's Syndrome -- Looking into the Crystal Ball: Initiatives from the Sjögren's Syndrome Foundation That Will Impact Patient Care -- Biological Treatment for Sjögren's Syndrome -- Looking into the Future-Emerging Therapies Based on Pathogenesis -- Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy.
  • 2014 Springer
    Hughes, Graham R. V.; Bowman, Simon; Sangle, Shirish.
    Sjögren's Syndrome is slowly being recognised as one of the most common auto-immune diseases, and considered pivotal in the spectrum of auto-immune disorders. Sjögren's Syndrome in Clinical Practice is a unique, concise book which explores important insights into Sjögren's links with other conditions and devotes itself to shedding new light on this disease. Aimed at young medics but also suitable for the informed lay reader, physicians and pharma, Sjögren's Syndrome in Clinical Practice will help with the diagnosis and treatment of this increasingly recognised disorder.
  • 2014 Springer
    Hall, John C.
    As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases. The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects. Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.
  • 2011
    Brownell, Sara Elaine; Robinson, William H.; Sapolsky, Robert M.; Shatz, Carla J.; Steinman, Lawrence.
    This thesis explores the use of small heat shock proteins as anti-inflammatory therapeutics in the context of neurological diseases, specifically multiple sclerosis (MS) and stroke. The family of small heat shock proteins (sHSPs) has been extensively studied as intracellular molecular chaperones. However, recent studies looking at the role of sHSPs in neurological diseases have demonstrated a near universal upregulation of certain sHSPs in damaged and diseased brains. Initially, it was thought that sHSPs are pathological in these disease states, but transgenic overexpression and exogenous administration of sHSPs in various experimental disease paradigms have shown just the contrary -- that sHSPs are protective, not pathological. In this thesis, I have found that members of the family of sHSPs are protective and therapeutic in mouse models of multiple sclerosis and stroke, experimental autoimmune encephalomyelitis (EAE) and middle cerebral artery occlusion (MCAO), respectively. Alpha B crystallin (cryab), a member of the sHSP family, is elevated in stroke and deficiency of cryab leads to worse disease outcome, illustrating the protective role of alpha B crystallin. Exogenous administration of small heat shock proteins, including alpha B crystallin, decreases disease severity by modulating the immune system. This leads to the conclusion that sHSPs are endogenous anti-inflammatory and neuroprotectant molecules produced after neurological disease, whose beneficial properties can be augmented when administered therapeutically.
  • 2013 ebrary
    Kotar, S. L.; Gessler, J. E.
    "Scientifically known as Variola major, the deadliest form of smallpox has plagued mankind since 'time immemorial.' This text chronicles the worldwide effects of the killer disease, with particular emphasis on the 19th and 20th centuries, including the devastations of the "speckled disease" during great armed conflicts"--Provided by publisher.
  • 2005 NAP
    Anason, Andrea; Baciu, Alina; Stratton, Kathleen R.; Strom, Brian L.
  • 2008 Springer
    Baier, G.
  • 2007 Springer
    Manser, Tim.
    Pattern recognition by B cells: the role of antigen repetitiveness versus toll-like receptors -- The multifunctional role of antibodies in the protective resonse to bacterial T cell-independent antigens -- The important anddiverse roles of antibodies in the host response to Borrelia infections -- A distinct role for B1b lymphocytes in T cell-independent immunity -- Secretory immunity following mutans streptococcal infection or immunization.
    Also available: Print – 2007
  • 2013 Springer
    Gulbins, Erich; Petrache, Irina.
    Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • 2009 WHO
    Maurice, J. M.; Davey, Sheila.
    Also available: Print – 2009
  • 2012 Springer
    Choukèr, Alexander.
    This book adopts an interdisciplinary approach in seeking to identify the impact of living conditions in space on the adaptation of the immune system.
  • 2007 Karger
    Marone, G.
    Also available: Print – 2007
  • v.1, 2=, 2010, 2016 Springer Protocols
    v.2 (2016) Springer Protocols
    Anegon, Ignacio; Cuturi, Maria Cristina.
  • 2013 Springer
    Richt, J. A.; Webby, Richard J.
    Overview of Influenza Viruses / Stephan Pleschka -- History of Swine Influenza / Stacey Schultz-Cherry, Christopher W. Olsen, Bernard C. Easterday -- Genetics, Evolution, and the Zoonotic Capacity of European Swine Influenza Viruses / Roland Zell, Christoph Scholtissek, Stephan Ludwig -- History of Swine Influenza Viruses in Asia / Huachen Zhu, Richard Webby, Tommy T. Y. Lam, David K. Smith -- Clinicopathological Features of Swine Influenza / B. H. Janke -- Diagnostics and Surveillance for Swine Influenza / Susan Detmer, Marie Gramer, Sagar Goyal, Montserrat Torremorell -- Contemporary Epidemiology of North American Lineage Triple Reassortant Influenza A Viruses in Pigs / Alessio Lorusso, Amy L. Vincent, Marie R. Gramer, Kelly M. Lager -- History and Epidemiology of Swine Influenza in Europe / Ian H. Brown -- Swine Influenza Viruses: An Asian Perspective / Young-Ki Choi, Philippe Noriel Q. Pascua, Min-Suk Song -- Swine Influenza Virus Vaccines: To Change or Not to Change--That's the Question / Kristien Van Reeth, Wenjun Ma -- Swine Influenza Virus Infections in Man / Whitney S. Krueger, Gregory C. Gray -- Interspecies Transmission of Influenza A Viruses Between Swine and Poultry / Hadi M. Yassine, Chang-Won Lee, Yehia M. Saif -- The 2009 Pandemic Influenza Virus: Where Did It Come from, Where Is It Now, and Where Is It Going? / Ian York, Ruben O. Donis -- Pandemic Influenza A H1N1 in Swine and Other Animals / Julia Keenliside -- Therapeutics Against Influenza / Elena A. Govorkova, Jonathan A. McCullers.
  • 2014 Springer Protocols
    Eggleton, Paul; Ward, Frank J.
    Pathology of Systemic Lupus Erythematosus - The Challenges Ahead -- The Lupus Biomarker Odyssey: One Experience -- Detection of Anti Nuclear Antibodies in SLE -- Tests for Circulating Immune Complexes -- Methods for Measuring Antibody Dependent Cell-Mediated Cytotoxicity in vitro -- Recombinant Antibody Microarray for Profiling the Serum Proteome of SLE -- Bi-functional Antibody Fragment-based Fusion Proteins for the Targeted Elimination of Pathogenic T-cell Subsets -- TLC Immunostaining for Detection of ?Anti-Phospholipid? Antibodies -- Induced Murine Models of Systemic Lupus Erythematosus -- Measuring Interferon Alpha and other Cytokines in SLE -- Detection of SLE antigens in Neutrophils Extracellular Traps (NETs) -- Detection and Characterization of Autoantibodies Against Modified Self-proteins in SLE Sera after Exposure to Reactive Oxygen and Nitrogen Species -- Generation of Self-peptides to Treat Systemic Lupus Erythematosus -- Measurement of Malondialdehyde, Glutathione and Glutathione Peroxidase in SLE Patients -- Evaluating a Particular Circulating MicroRNA Species from an SLE Patient using Stem Loop qRT-PCR -- Microarray Technology for Analysis of MicroRNA Expression in Renal Biopsies of Lupus Nephritis Patients. Laboratory Tests for the Antiphospholipid Syndrome -- Isolation, Polarisation and Expansion of CD4+ T Helper Cell Lines and Clones using Magnetic Beads -- Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus.
  • 2011 ClinicalKey
    Lahita, Robert G.
    Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Lupus is the prototypic autoimmune disease and SLE examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
  • 2013 Springer
    Katze, Michael G.
    First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.
  • 2007 Springer
    Moody, D. Branch.
    Also available: Print – 2007
  • 2009 Springer Protocols
    De Libero, Gennaro.
    Analysis of frequency and phenotype of antigen-specific T cells / Angus Stock and Vincenzo Cerundolo -- B cell helper assays / Sergio Abrignani, ... [et al.] -- Transkingdom RNA interference (tkRNAi) / Thu A. Nguyen and Johannes H. Fruehauf -- Flow cytometry and cell activation / Sonia Gavasso -- Investigating T cells by polychromatic flow cytometry / Enrico Lugli, Leonarda Troiano, and Andrea Cossarizza -- Generation of human T cell clones / Sabrina Mariotti and Roberto Nisini -- Limiting dilution analysis of antigen-specific T cells / Jorge Carneiro, Lurdes Duarte, and Elisabetta Padovan -- T cell epitope-mapping by cytokine gene expression assay / Maurizio Provengano and Giulio C. Spagnoli -- Cytokine multiplex immunoassay / Wilco de Jager, Berent Prakken, and Ger T. Rijkers -- Purification of the T cell antigen receptor and analysis by blue-native PAGE / Mahima Swamy and Wolfgang W.A. Schamel -- Non-replicating recombinant vaccinia virus expressing CD80 to enhance T-cell stimulation / Paul Zajac.
  • 2008 Karger
    Blaser, Kurt.
    Also available: Print – 2008
  • 2009 Springer
    Kishore, Uday.
    Macrophage pattern recognition receptors in immunity, homeostasis, and self tolerance / Subhankar Mukhopadhyay, Annette Plüddemann, and Siamon Gordon -- Pattern recognition by toll-like receptors / Stefan Bauer, Thomas Müller, and Svetlana Hamm -- Nod-like receptors : pivotal guardians of the immunological integrity of barrier organs / Philip Rosenstiel and Stefan Schreiber -- Toll-like receptors and nod-like receptors : domain architecture and cellular signalling / Tanja Langefeld ... [et al.] -- Humoral pattern recognition molecules : mannan-binding lectin and ficolins / Steffen Thiel and Mihaela Gadjeva -- Lung surfactant proteins A and D as pattern recognition proteins / Patrick Waters ... [et al.] -- Pattern recognition by pentraxins / Alok Agrawal ... [et al.] -- Target pattern recognition by complement proteins of the classical and alternative pathways / Yu-hoi Kang ... [et al.] -- Pattern recognition in phagocytic clearance of altered self / Yoshinobu Nakanishi, Peter M. Henson and Akiko Shiratsuchi -- Structural basis of pattern recognition by innate immune molecules / Eamon P. McGreal -- Lessons from the fly : pattern recognition in Drosophila melanogaster / Subhamoy Pal and Louisa P. Wu -- Immune recognition of plasmodium-infected erythrocytes / Damien V. Cordery and Britta C. Urban -- Innate immune recognition in tuberculosis infection / Anthony G. Tsolaki.
    Also available: Print – 2009
  • 2011 Springer
    Jackman, Ann L.; Leamon, Christopher P.
  • 2015 Springer Protocols
    Bosselut, Rémy; Vacchio, Melanie S.
    200 million thymocytes and I: A beginner's survival guide to t cell development -- Development of [gamma][delta] T cells, the special-force soldiers of the immune system -- Genetic tools to study T cell development -- Assessment of T cell development by flow cytometry -- Flow cytometry analysis of thymic epithelial cells and their subpopulations -- Identifying the spatial relationships of thymic stromal and thymocyte subsets by immunofluorescence analysis -- Purification of thymocyte and T cell subsets -- Retroviral transduction of T cells and T cell precursors -- Bone marrow and fetal liver radiation chimeras -- In vitro analyses of T cell effector differentiation -- Studying T cell development in thymic slices -- FTOC-based analysis of negative selection -- Reconstituted thymus organ culture -- Induction of T cell development in vitro by delta-like (Dll)-expressing stromal cells -- In vitro analysis of thymocyte signaling -- Molecular analysis of mouse T cell receptor [alpha] and [beta] gene rearrangements -- Intrathymic injection -- Analysis of cell proliferation and homeostasis using EdU labeling -- Characterization and isolation of human T cell progenitors -- Approaches to study human T cell development -- Humanized mice to study human T cell development -- Using the zebrafish model to study T cell development.
  • 2013 Springer
    Foss, Francine.
    The mature T and NK cell lymphomas are rare, comprising approximately 10% of all malignant lymphomas. The incidence of T-cell lymphoma is variable around the world, with a higher incidence compared to B-cell lymphomas in the Asian basin. While the overall incidence of B-cell lymphomas has begun to decline in the United States, the incidence of T-cell lymphomas continues to rise. Over the last decade, a number of novel agents have been developed which target T-cell lymphomas and studies have identified novel genes and pathways associated with lymphomagenesis in T-cells. This comprehensive volume examines the clinical and biological aspects of the T-cell lymphoproliferative disorders in adults and children. The book includes an overview of both the cutaneous and the systemic T-cell malignancies and addresses the classification of T-cell lymphomas, the clinical features of each subtype, and the relevant molecular and genetic studies. Clinical outcomes and treatment strategies are discussed with an emphasis on the development of novel biological and targeted therapies. An outstanding resource for hematologists and oncologists, this book gathers insights from experts in the field and provides the most up-to-date information on all of the T-cell lymphoma subgroups and current and emerging therapies.
  • 2013 Springer
    Chan, Edward K. L.; Fritzler, Marvin J.
    Introduction: The GW Body Story as an Example of Autoantibodies with Significant Impacts to Molecular Cell Biology -- The Discovery of GW Bodies -- The Discovery and Analysis of P Bodies -- Autoantibodies to Argonaute 2 (Su Antigen) -- GW/P-Bodies and Autoimmune Disease -- Function of GW182 and GW Bodies in siRNA and miRNA Pathways -- Post-transcriptional Stimulation of Gene Expression by MicroRNAs -- Gawky (GW) is the Drosophila melanogaster GW182 Homologue -- The Role of GW182 Proteins in miRNA-Mediated Gene Silencing -- Quantifying Argonaute Proteins In and Out of GW/P-Bodies: Implications in microRNA Activities -- Deadenylation and P-Bodies -- Relationship of GW/P-Bodies with Stress Granules -- Relationship of Other Cytoplasmic Ribonucleoprotein Bodies (cRNPB) to GW/P Bodies -- An SNP in the Trinucleotide Repeat Region of the TNRC6A Gene Maps to a Major TNGW1 Autoepitope in Patients with Autoantibodies to GW182 -- Reflections on Ten Years of History of, and Future Prospects for, GW182 and GW/P Body Research.
    Also available: Print – 2013
  • 2010
    Kattah, Nicole Hanick; Davis, Mark M.; Robinson, William H.; Steinman, Lawrence; Utz, Paul J.
    Antigen-specific CD4+ T cells have been implicated in the autoimmune disease systemic lupus erythematosus (SLE), yet little is known about the function of these T cells or the precise peptide antigens that they recognize. We hypothesized that antigen-specific CD4+ T cells contribute to lupus pathology through two mechanisms: (1) by providing help to B cells for pathogenic autoantibody production, and (2) by directly promoting inflammation through the secretion of proinflammatory cytokines. We tested these two hypotheses by generating a series of MHC class II tetramers of I-Ek containing peptides from the spliceosomal protein U1-70. These tetramers specifically stained distinct CD4+ T cell populations in MRL/lpr mice. Using these reagents, we demonstrated that CD4+ T cells specific for U1-70 (131-150):I-Ek correlated with disease and with anti-U1-70 autoantibody production, expressed ROR[lowercase gamma]t and Tbet, and produced IFN[lowercase gamma] and IL-17A in an I-Ek-dependent manner. We confirmed our findings from mice in human patients with SLE and mixed connective tissue disease (MCTD). U1-70 specific CD4+ T cells obtained from peripheral blood mononuclear cells (PBMCs) of patients with SLE produced IFN[lowercase gamma] in all 5 patients tested and IL-17A in 1 out of 2 patients whose serum contained RNP autoantibodies. These data support the hypotheses that antigen-specific T cells recognize the same autoantigens as B cells, and that they produce proinflammatory cytokines. These studies represent the first reported tetramers for studying antigen-specific T cells in a mouse model of lupus, and demonstrate an antigen-specific source of IL-17A in human autoimmune disease.
  • 2009 Springer
    Di Padova, Franco; Quesniaux, Valérie; Ryffel, Bernhard.
    Also available: Print – 2009
  • 2011 Springer
    Jiang, Shuiping.
  • 2014 Springer Protocols
    Becher, Burkhard; Waisman, Ari.
    Isolation of T cells from the skin / Beate Lorenz and Esther von Stebut -- Isolation of leukocytes from mouse central nervous system / Iva Lelios and Melanie Greter -- Isolation of T cells from the gut / Sonja Reissig, Christopher Hackenbruch, and Nadine Hövelmeyer -- T cell isolation from mouse kidneys/ Isis Ludwig-Portugall and Christian Kurts -- Intracellular staining for cytokines and transcription factors / Florian Mair and Vinko Tosevski -- Tracking cells and monitoring proliferation / Vinko Tosevski and Florian Mair -- Mass cytometry analysis of human T cell phenotype and function / Evan W. Newell and Lai Li Yun -- Detection of NF-[kappa]B pathway activation in T helper cells / Oliver Gorka, Stefan Wanninger, and Jürgen Ruland -- Assessing the suppressive activity of Foxp3⁺ regulatory T cells / Christian Thomas Mayer and Tim Sparwasser -- In vitro generation of microbe-specific human Th17 cells / Julia M. Braun and Christina E. Zielinski -- In vitro polarization of T-helper cells / Julie Rumble and Benjamin M. Segal -- A method for the generation of TCR retrogenic mice / Elisa Kieback, Ellen Hilgenberg, and Simon Fillatreau -- Mouse models of allergic airway disease / Helen Meyer-Martin, Sebastian Reuter, and Christian Taube -- Induction of colitis in mice (T-cell transfer model) / Benno Weigmann -- Manipulation of T cell function and conditional gene targeting in T cells / Anna Śledzińska,Lynsey Fairbairn, and Thorsten Buch -- Aldara-induced psoriasis-like skin inflammation : Isolation and characterization of cutaneous dendritic cells and innate lymphocytes / C.T. Wohn ... [et al.] -- Induction of passive EAE using myelin-reactive CD4+ T cells / Rhoanne C. McPherson ... [et al.] -- Experimental mouse models of T cell-dependent inflammatory bowel disease / George X. Song-Zhao and Kevin J. Maloy -- Analysis of chromosomal aberrations in murine HCC / Kristian Unger and Mathias Heikenwälder.
  • 2008 Springer
    Chernajovsky, Yuti; Nissim, Ahuva.
  • 2012 Springer
    Mellinghoff, Ingo K.; Sawyers, Charles L.
    Setting up a Kinase Discovery and Development Project / Gideon Bollag -- Drug Efficacy Testing in Mice / William Y. Kim, Norman E. Sharpless -- Gastrointestinal Stromal Tumors / Cristina Antonescu -- EGFR Mutant Lung Cancer / Yixuan Gong, William Pao -- Targeting Oncogenic BRAF in Human Cancer / Christine A. Pratilas, Feng Xing, David B. Solit -- Beyond BRAF in Melanoma / Adil Daud, Boris C. Bastian -- JAK-Mutant Myeloproliferative Neoplasms / Ross L. Levine -- Will Kinase Inhibitors Make it as Glioblastoma Drugs? / Ingo K. Mellinghoff, Nikolaus Schultz, Paul S. Mischel -- Predictive Genomic Biomarkers / Rakesh Kumar, Rafael G. Amado -- Epigenetic Biomarkers / Timothy A. Chan, Stephen B. Baylin -- Adjuvant Trials of Targeted Agents: The Newest Battleground in the War on Cancer / Robert L. Cohen.
    Also available: Print – 2012
  • 2009 Springer
    Grewal, Iqbal S.
    Overview of TNF superfamily : a chest full of potential therapeutic targets / Iqbal S. Grewal -- Therapeutic interventions targeting CD40l (CD154) and CD40 : the opportunities and challenges / Che-Leung Law and Iqbal S. Grewal -- Targeting TNF for treatment of cancer and autoimmunity / Gautam Sethi ... [et al.] -- Targeting of BAFF and APRIL for autoimmunity and oncology / Maureen C. Ryan and Iqbal S. Grewal -- The role of FASL and FAS in health and disease / Martin Ehrenschwender and Harald Wajant -- OX40 (CD134) and OX401 / Michael J. Gough and Andrew D. Weinberg -- Targeting CD70 for human therapeutic use / Tamar Boursalian ... [et al.] -- 4-1BB as a therapeutic target for human disease / Seung-Woo Lee and Michael Croft -- Rank(l) as a key target for controlling bone loss / Andreas Leibbrandt and Josef M. Penninger -- Targeting the light-HVEM pathway / Carl F. Ware -- GITR : a modulator of immune response and inflammation / Giuseppe Nocentini and Carlo Riccardi -- Targeting CD30/CD30l in oncology and autoimmune and inflammatory diseases / Ezogelin Oflazoglu, Iqbal S. Grewal, and Hans Peter Gerber -- Tumor necrosis factor receptor superfamily member 21 : TNFR-related death receptor-6, DR6 / Robert Benschop, Tao Wei, and Songqing Na -- TRAIL and other TRAIL receptor agonists as novel cancer therapeutics / Christina Falschlehner ... [et al.] -- Therapeutic potential of VEGI/TL1A -- In autoimmunity and cancer / Gautam Sethi, Bokyung Sung, and Bharat B. Aggarwal.
    Also available: Print – 2009
  • 2014 Springer
    Boehm, T. L. J.; Takahama, Yousuke.
    The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.
  • 2014 Springer Protocols
    Bayry, Jagadeesh.
    Assaying NF-[kappa]B activation and signaling from TNF receptors -- Dissecting DR3 signaling -- Modulation of fc[epsilon]RI-dependent mast cell response by OX40L -- Analyzing the signaling capabilities of soluble and membrane TWEAK -- Regulation of human dendritic cell functions by natural anti-cd40 antibodies -- [Beta]-actin in the signaling of transmembrane TNF-[alpha]-mediated cytotoxicity -- Investigating the protective role of death receptor 3 (DR3) in renal injury using an organ culture model -- Analysis of TNF-[alpha]-mediated cerebral pericyte remodeling -- CD137 in chronic graft-versus-host disease -- In vitro investigation of the roles of the proinflammatory cytokines tumor necrosis factor-[alpha] and interleukin-1 in murine osteoclastogenesis -- Evasion of TNF-[alpha]-mediated apoptosis by hepatitis C virus -- TNF-[alpha] modulates TLR2-dependent responses during mycobacterial infection -- Experimental applications of TNF-reporter mice with far-red fluorescent label -- A solid-phase assay for studying direct binding of progranulin to TNFR and progranulin antagonism of TNF/TNFR interactions -- Compartment-specific flow cytometry for the analysis of TNF-mediated recruitment and activation of glomerular leukocytes in murine kidneys -- Determination of soluble tumor necrosis factor receptor 2 produced by alternative splicing -- Effective expression and purification of bioactive recombinant soluble LIGHT -- One of the TNF superfamily members: Bifunctional protein, TNFR2-Fc-IL-1ra.
  • 2006 Springer
    Buchholz, R.; Weinberg, J. M.
  • 2005 Springer
    Rich, Tina.
    Introduction: toll receptors and the renaissance of innate immunity / Elizabeth H. Bassett and Tina Rich -- The function of toll-like receptors / Zlatko Dembic -- Structures and motifs involved in toll signaling / Monique Gangloff, Phumzile L. Ludidi and Nicholas J. Gay -- "Supramolecular" activation clusters in innate immunity / Martha Triantafilou and Kathy Triantafilou -- Interleukin-I receptor/toll-like receptor signaling / Harald Wajant, Peter Scheurich and Frank Henkler -- Virus induced signaling to initiate the interferon mediated anti-viral host response / Claudia Wietek and Luke A.J. O'Neill -- The induction of dendritic cell activation and maturation by toll-like receptor signaling / Tsuneyasu Kaisho and Shizuo Akira -- Pathogen avoidance using toll signaling in C. elegans / Nathalie Pujol and Jonathan J. Ewbank -- Forward genetic analysis of TLR pathways: a shared system for the detection of endotoxin and viral infection / Bruce Beutler ... [et al.] -- Agonists of toll-like receptor 9: modulation of host immune responses with synthetic oligodeoxynucleotides / Ekambar R. Kandimalla and Sudhir Agrawal.
  • 2009 Springer
    Kielian, Tammy.
    Overview of toll-like receptors in the CNS / Tammy Kielian -- Toll-like receptors in bacterial meningitis / Uwe Koedel -- Toll-like receptors in brain abscess / Nilufer Esen and Tammy Kielian -- Toll-like receptors in CNS viral infections / Hyeon-Sook Suh, Celia F. Brosnan and Sunhee C. Lee -- Toll-like receptors in CNS parasitic infections / Bibhuti B. Mishra, Uma Mahesh Gundra and Judy M. Teale -- Toll-like receptors in neurodegeneration / Trevor Owens -- Toll-like receptors in spinal cord injury / Kristina A. Kigerl and Phillip G. Popovich -- Toll-like receptors in Alzheimer's disease / Gary E. Landreth and Erin G. Reed-Geaghan -- Toll-like receptors in multiple sclerosis / Michael K. Racke and Phil D. Drew -- Toll-like receptors in peripheral nerve injury and neuropathic pain / Donghoon Kim, Soojin Lee and Sung Joong Lee.
    Also available: Print – 2009
  • 2005 Springer
    Brint, Elizabeth; O'Neill, Luke A. J.
    Also available: Print – 2005
  • 2008 Springer
    Akira, Shizuo; Bauer, Stefan; Hartmann, Gunther.
  • 2010
    Ong, Yi-Ching; Bogyo, Matthew; Boothroyd, John C.; Mochly-Rosen, Daria; Nolan, Garry P.
    Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.
  • 2014 Springer
    Ellmeier, Wilfried; Taniuchi, Ichiro.
    Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
  • 2013 Springer Protocols
    Leffell, Mary S.; Zachary, Andrea A.
    Alloreactivity / Sidonia B.G. Eckle, Jamie Rossjohn, and James McCluskey -- Antibodies in Transplantation : The Effects of HLA and Non- HLA Antibody Binding and Mechanisms of Injury / Nicole M. Valenzuela and Elaine F. Reed -- Cell Mediated Rejection / Kathryn J. Wood, Masaaki Zaitsu, and Ryoichi Goto -- Transplantation Tolerance / Colin Brinkman ... [et al.] -- Composite Tissue Transplantation / Gerald Brandacher -- Transplantation of the Sensitized Patient: Histocompatibility Testing / Robert A. Montgomery, Mary S. Leffell, and Andrea A. Zachary -- Thoracic Organ Transplantation : Laboratory Methods / Jignesh K. Patel and Jon A. Kobashigawa -- HLA Typing by Sequence-Specific Primers / Mike Bunce and Ben Passey -- Human Leukocyte Antigen (HLA) Typing by DNA Sequencing / Ana Lazaro ... [et al.] -- Next-Generation HLA Sequencing Using the 454 GS FLX System / Elizabeth A. Trachtenberg and Cherie L. Holcomb -- Chimerism Testing by Quantitative PCR Using Indel Markers / Ketevan Gendzekhadze, Laima Gaidulis, and David Senitzer -- Gene-Specific PCR Typing of Killer Cell Immunoglobulin- Like Receptors / Raja Rajalingam and Elham Ashouri -- Complement-Dependent Cytotoxicity Crossmatch / Jeremy Ryan Pena, Donna Fitzpatrick, and Susan L. Saidman -- Lymphocyte Crossmatching by Flow Cytometry / Robert A. Bray -- Solid Phase Assay Measuring C4d Deposition to Determine Complement Fixation by HLA-Specific Antibodies / John D. Smith and Marlene L. Rose -- C1q Assay for the Detection of Complement Fixing Antibody to HLA Antigens / Ge Chen and Dolly B. Tyan -- Tetramer Staining for the Detection of HLA-Specific B cells / Donna P. Lucas, Mary S. Leffell, and Andrea A. Zachary -- Flow Cytometric Crossmatch Test Using Endothelial Precursor Cells Isolated from Peripheral Blood / Annette M. Jackson, Donna P. Lucas, and Jessica L. Badders -- Detection of Antibodies to the Angiotensin II-Type 1 Receptor in Transplantation / Duska Dragun -- Detection of Antibodies to Self-Antigens (K-alpha 1 Tubulin, Collagen I, II, IV, and V, Myosin, and Vimentin) by Enzyme-Linked Immunosorbent Assay (ELISA) / Nayan J. Sarma, Venkataswarup Tiriveedhi, and T. Mohanakumar -- Cylex ImmuKnow Cell Function Assay / Adriana Zeevi and John Lunz -- Detection of Intracellular Cytokines / Nancy L. Reinsmoen and Chih-Hung Lai -- Tolerogenic Dendritic Cells and Induction of T Suppressor Cells in Transplant Recipients / George Vlad and Nicole Suciu-Foca -- Discovery and Customized Validation of Antibody Targets by Protein Arrays and Indirect ELISA / Tara K. Sigdel and Minnie M. Sarwal -- RNA Purification and Expression Analysis Using Microarrays and RNA Deep Sequencing / Steven R. Head ... [et al.].
  • 2006 Springer Protocols
    Hornick, Philip; Rose, Marlene L.
    Current status of renal transplantation / Christopher J. Callaghan and J. Andrew Bradley -- Current status of liver transplantation / Peter J. Friend and Charles J. Imber -- Current status of islet transplantation / Jonathan R.T. Lakey, Mohammadreza Mirbolooki, and A.M. James Shapiro -- Current status of lung transplantation / Allan R. Glanville -- Chronic rejection in the heart / Philip Hornick and Marlene Rose -- Direct and indirect allorecognition / Philip Hornick -- HLA typing and its influence on organ transplantation / Stephen Sheldon and Kay Poulton -- Strategies for gene transfer to solid organs: viral vectors / Charlotte Lawson -- Nonviral vectors / Louise Collins -- Detection and clinical relevance of antibodies after transplantation / John D. Smith and Marlene Rose -- Reprogramming the immune system using antibodies / Luis Graca and Hermann Waldmann -- In vitro assays for immune monitoring in transplantation / Maria P. Hernandez-Fuentes and Alan Salama -- Proteomics and laser microdissection / Emma McGregor and Ayesha DeSouza -- Real-time quantitative polymerase chain reaction in cardiac transplant research / Leanne E. Felkin, Anne B. Taegtmeyer, and Paul J.R. Barton -- Organ preservation / Mark Hicks ... [et al.] -- Pharmacological manipulation of the rejection response / Peter Mark Anthony Hopkins -- Experimental models of graft arteriosclerosis / Bezhad Soleimani and Victor C. Shi.
  • 2008 Karger
    Egesten, Arne; Herwald, Heiko; Schmidt, Axel.
    From Darwin and Metchnikoff to Burnet and beyond / Cooper, E.L. -- General introduction to innate immunity: Dr. Jekyl/Mr. Hyde quality of the innate immune system / Zonker, K.S. -- The innate immune system of mammals and insects / Müller, U. ... [et al.] -- Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands / Areschoug, T., Gordon, S. -- Antimicrobial peptides in innate immune responses / Sorensen, O.E., Borregaard, N., Cole, A.M. -- Complement: an efficient sword of innate immunity / Rambach, G., Würzner, R., Speth, C. -- Antibacterial chemokines: actors in both innate and adaptive immunity / Eliasson, M., Egesten, A. -- The role of neutrophils and monocytes in innate immunity / Kantari, C., Pederzoli-Ribeil, M., Witko-Sarsat, V. -- Innate immune functions of the airway epithelium / Bartlett, J.A., Fischer, A.J., McCray, Jr, P.B. -- Oxidative innate immune defenses by Nox/Duox family NADPH oxidases / Rada, B., Leto, T.L. -- Aging and impairment of innate immunity / Nomellini, V., Gomez, C.R., Kovacs, E.J.
    Also available: Print – 2008
  • 2013 Springer
    Malyguine, Anatoli; Shurin, Michael R.; Umansky, Viktor.
    Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
  • 2005 Springer
    Khleif, Samir N.
    Also available: Print – 2005
  • 2005 Karger
    Dvorak, Ann M.
    Also available: Print – 2005
  • 2010 Springer
    Grattan, Clive; Maurer, Marcus; Zuberbier, T.
    History of Urticaria / M. Greaves -- Aetiopathogenesis of Urticaria / Clive E. H. Grattan -- Classification of Urticaria / Torsten Zuberbier -- Impact of Urticaria: QOL and Performance / Ilaria Baiardini, Fulvio Braido and Giorgio Walter Canonica -- Acute Urticaria / Torsten Zuberbier -- Chronic Urticaria / Marcus Maurer -- Dermographic and Delayed Pressure Urticaria / Frances Lawlor -- Heat and Cold Urticaria / Carsten Bindslev-Jensen -- Solar Urticaria / Tatsuya Horikawa, Atsushi Fukunaga and Chikako Nishigori -- Cholinergic Urticaria and Exercise-Induced Anaphylaxis / Ruth A. Sabroe -- Contact Urticaria / Jürgen Grabbe -- Urticarial Syndromes and Autoinflammation / Kanade Shinkai and Kieron S. Leslie -- Urticaria Vasculitis / Lluís Puig -- Angioedema / Elena Borzova and Clive E. H. Grattan -- Therapy of Urticaria / Bettina Wedi -- Standard Operating Procedures: A Practical Approach / M. Metz and M Magerl.
  • 2011
    Ruebush, Mary; Hawley, Louise.
    Status: Not Checked OutLane Catalog Record
    SECTION I. Immunology -- Chapter 1. Overview of the immune system -- Chapter 2. Cells of the immune system -- Chapter 3. The selection of lymphocytes -- Chapter 4. Lymphocyte recirculation and homing -- Chapter 5. The first response to antigen -- Chapter 6. The processing and presentation of antigen -- Chapter 7. The generation of humoral effector mechanisms -- Chapter 8. The generation of cell-mediated effector mechanisms -- Chapter 9. The generation of immunologic memory -- Chapter 10. Vaccination and immunotherapy -- Chapter 11. Immunodeficiency diseases -- Chapter 12. Acquired immunodeficiency syndrome -- Chapter 13. Diseases caused by immune responses: hypersensitivity and autoimmunity -- Chapter 14. Transplantation immunology -- Chapter 15. Laboratory techniques in immunology -- Appendix I. CD markers -- Appendix II. Cytokines -- Appendix III. Adhesion molecules -- Appendix IV. Mechanisms of resistance to microbial infections -- SECTION II. Microbiology -- Chapter 1. General microbiology -- Chapter 2. Medically important bacteria -- Chapter 3. Microbial genetics/drug resistance -- Chapter 4. Medically important viruses -- Chapter 5. Medically important fungi -- Chapter 6. Medical parasitology -- Chapter 7. Clinical infectious disease -- Chapter 8. Comparative microbiology -- Chapter 9. Flow charts/clue sheets -- Index.
  • 2006 Springer
    Hackett, Charles J.; Harn, Donald A.
    Microbial pathogenesis and the discovery of toll-like receptor function / Bruce Beutler -- Dendritic cells: targets for immune modulation by microbes and immunologists / Bali Pulendran ... [et al.] -- Achieving transcriptional specificity in NF-[gamma]B-dependent inflammatory gene expression / Gioacchino Natoli -- Adjuvants and the initiation of t-cell responses / Matthew F. Mescher, Julie M. Curtsinger, and Marc Jenkins -- Mechanism for recognition of CpG DNA / Kiyoshi Takeda, Hiroaki Hemmi, and Shizuo Akira -- CpG ODN as a Th1 immune enhancer for prophylactic and therapeutic vaccines / Arthur M. Kried and Heather L. Davis -- Modified bacterial toxins / Ed C. Lavelle, Olive Leavy, and Kingston H.G. Mills -- Glycosylphosphatidylinositol anchors as natural immunological adjuvants derived from protozoan parasites / Ricardo T. Gazzinelli ... [et al.] -- The immunomodulatory glycan LNFPIII/Lewis X functions as a potent adjuvant for protein antigens / Mitsuhiro Okano ... [et al.] -- Immune and antiviral effects of the synthetic immunomodulator murabutide: molecular basis and clinical potential / George M. Bahr -- Effect of QS-21 on innate and adaptive immune responses / Charlotte Read Kensil ... [et al.] -- Monophosphoryl lipid A and synthetic lipid a mimetics as TLR4-based adjuvants and immunomodulators / Jory Baldridge ... [et al.] -- Microparticles and DNA vaccines / Kimberly Denis-Mize ... [et al.].
  • 2005 NAP
  • 2016 Springer Protocols
    Brun, Alejandro.
    Vaccines and vaccination for veterinary viral diseases : a general overview / Alejandro Brun -- Using IC-tagging methodology for production and purification of epitope-loaded protein microspheres for vaccination / Natalia Barreiro- Piñeiro ... [et al.] -- Plant-based vaccine antigen production / Hoang Trong Phan and Udo Conrad -- DNA vaccines : experiences in the swine model / Francesc Accensi, Fernando Rodríguez, and Paula L. Monteagudo -- Novel adjuvants and immunomodulators for veterinary vaccines / Peter M.H. Heegaard, Yongxiang Fang, and Gregers Jungersen -- Polymerase mechanism-based method of viral attenuation / Cheri A. Lee ... [et al.] -- BacMam platform for vaccine antigen delivery / Günther M. Keil ... [et al.] -- Laboratory-scale production of replication-deficient adenovirus vectored vaccines / Susan J. Morris ... [et al.] -- Generation of recombinant modified vaccinia virus ankara encoding VP2, NS1, and VP7 proteins of bluetongue virus / Alejandro Marín- López and Javier Ortego -- Generation of recombinant capripoxvirus vectors for vaccines and gene knockout function studies / Hani Boshra, Jingxin Cao, and Shawn Babiuk -- Recombinant swinepox virus for veterinary vaccine development / Hong-Jie Fan and Hui-Xing Lin -- Generation and selection of Orf virus (ORFV) recombinants / Hanns-Joachim Rziha, Jörg Rohde, and Ralf Amann -- Polycistronic herpesvirus amplicon vectors for veterinary vaccine development / Anita Felicitas Meier, Andrea Sara Laimbacher, and Mathias Ackermann -- Construction and application of newcastle disease virus-based vector vaccines / Paul J. Wichgers Schreur -- Chimeric pestivirus experimental vaccines / Ilona Reimann, Sandra Blome, and Martin Beer -- Analysis of the cellular immune responses to vaccines / Nicholas Svitek ... [et al.].
  • 2010 Springer
    Artenstein, Andrew W.
    Vaccinology in context : the historical burden of infectious diseases / Andrew W. Artenstein -- Smallpox / Andrew W. Artenstein -- A brief history of microbiology and immunology / Steven M. Opal -- Anthrax / Peter C.B. Turnbull -- Rabies / Hervé Bourhy, Annick Perrot, and Jean-Marc Cavaillon -- Killed vaccines : cholera, typhoid, and plague / Charles C.J. Carpenter and Richard B. Hornick -- Toxoid vaccines / John D. Grabenstein -- Tuberculosis and BCG / Marina Gheorghiu, Micheline Lagranderie, and Anne-Marie Balazuc -- The discovery of viruses and the evolution of vaccinology / Nicholas C. Artenstein and Andrew W. Artenstein -- Yellow fever / Thomas P. Monath -- Influenza / Andrew W. Artenstein -- Polio / David Oshinsky -- Measles, mumps, and rubella / Kathleen M. Gallagher ... [et al.] -- Diseases of military importance / Alan Cross and Phil Russell -- Varicella and zoster / Anne A. Gershon -- Polysaccharide vaccines / Andrew W. Artenstein -- Hepatitis B / Baruch S. Blumberg -- Japanese encephalitis / Scott B. Halstead -- Hepatitis A / Leonard N. Binn and Stanley M. Lemon -- Rotavirus / Penelope H. Dennehy -- Human papillomaviruses / Ian H. Frazer -- The future of vaccine discovery and development / Adel Mahmoud.
  • 2011 Springer
    Coffman, Robert L.; Valenta, Rudolf.
    Immunological approaches for tolerance induction in allergy -- Clinical experience with recombinant molecules for allergy vaccination -- Allergen-specific immunotherapy with recombinant allergens -- Vaccine approaches for food allergy -- Intralymphatic immunotherapy: From the rationale to human applications -- Induction of allergen-specific tolerance via mucosal routes -- T cell epitope-based allergy vaccines -- Allergen-specific immunotherapy: Towards combination vaccines for allergic and infectious diseases -- Passive immunization with allergen-specific antibodies -- Cell-based therapy in allergy -- Current strategies for allergen-specific immunotherapy at its centenary.
    Also available: Print – 2011
  • 2009 ScienceDirect
    Barrett, A. D. T.; Stanberry, Lawrence R.
  • 2009 Springer
    Compans, Richard W.; Orenstein, Walter A.
    Part I. Pandemic Influenza Overview -- Pandemic influenza as a current threat -- Antigenic cross-reactivity among H5N1 Viruses -- -- Part II. Current Approaches for Human and Avian Vaccine Production -- Seasonal influenza vaccines -- Generation and characterization of candidate vaccine viruses for pre-pandemic influenza vaccines -- Live attenuated vaccines for pandemic influenza -- Influenza vaccines for avian species -- Development and application of avian influenza vaccines in China -- -- Part III. Novel Vaccine Approaches -- Designing vaccines for pandemic influenza -- Attenuated influenza virus vaccines with modified NS1 proteins -- DNA Vaccines against Influenza viruses -- Recombinant proteins produced in insect cells -- Influenza neuraminidase as a vaccine antigen -- Recombinant vectors as influenza vaccines -- Influenza virus-like particles as pandemic vaccines -- Pandemic influenza vaccines -- Adjuvants for pandemic influenza vaccines -- -- Part IV. Novel Approaches of Vaccine Delivery -- Transcutaneous immunization with influenza vaccines -- Microneedle-based vaccines -- -- Part V. Vaccine Evaluation, Production and Distribution -- Animal models for evaluation of influenza vaccines -- Immunosenescence and influenza vaccine efficacy -- Vaccines for pandemic influenza: summary of recent clinical trials -- Considerations for licensure of influenza vaccines with pandemic and pre-pandemic indications -- Strategies for broad global access to pandemic influenza -- Prioritization of pandemic influenza vaccine: rationale and strategy for decision-making.
    Also available: Print – 2009
  • 2013 ClinicalKey
    Offit, Paul A.; Orenstein, Walter A.; Plotkin, Stanley A.
    A short history of vaccination -- Vaccine immunology -- The vaccine industry -- Vaccine manufacturing -- Evolution of adjuvants across the centuries -- Vaccine additives and manufacturing residuals in the United States: licensed vaccines -- Passive immunization -- General immunization practices -- Adenovirus vaccines -- Anthrax vaccines -- Cholera vaccines -- Diphtheria toxoid -- Haemophilus influenzae vaccines -- Hepatitis A vaccines -- Hepatitis B vaccines -- Human papillomavirus vaccines -- Inactivated influenza vaccines -- Influenza vaccine-live -- Japanese encephalitis vaccines -- Measles vaccine -- Meningococcal vaccines -- Mumps vaccine -- Pertussis vaccines -- Plague vaccines -- Pneumococcal conjugate vaccine and pneumococcal common protein vaccines -- Pneumococcal polysaccharide vaccines -- Poliovirus vaccine-inactivated -- Poliovirus vaccine-live -- Rabies vaccines -- Rotavirus vaccines -- Rubella vaccine -- Smallpox and vaccinia -- Tetanus toxoid -- Tick-borne encephalitis virus vaccines -- Tuberculosis vaccines -- Typhoid fever vaccines -- Varicella vaccine -- Yellow fever vaccine -- Zoster vaccine -- Combination vaccines -- Biodefense and special pathogen vaccines -- Therapeutic cancer vaccines -- Cytomegalovirus vaccines -- Dengue vaccines -- Diarrhea caused by bacteria -- Ebola vaccine -- Epstein-Barr virus vaccines -- Hepatitis C vaccines -- Hepatitis E vaccines -- Herpes simplex virus vaccines -- Human immunodeficiency virus vaccines -- Lyme disease vaccines -- Malaria vaccines -- Noninfectious disease vaccines -- Respiratory syncytial virus and parainfluenza virus vaccines -- Parasitic disease vaccines -- Staphylococcus aureus vaccines -- Streptococcus group A vaccines -- Technologies for making new vaccines -- Alternative vaccine delivery methods -- The development of gene-based vectors for immunization -- Vaccination of immunocompromised hosts -- Vaccination of human immunodeficiency virus-infected persons -- Vaccines for international travel -- Vaccines for health care personnel -- Immunization in the United States -- Immunization in Europe -- Immunization in the Asia-Pacific region -- Immunization in developing countries -- Community immunity -- Economic analyses of vaccine policies -- Regulation and testing of vaccines -- Regulation of vaccines in Europe -- Regulation of vaccines in developing countries -- Vaccine safety -- Legal issues -- Ethics.
  • 2013 Springer
    Chatterjee, Archana.
    The History of Vaccine Challenges: Conquering Diseases, Plagued by Controversy / Laura A. Jana -- Vaccine Development and Safety / Avinash K. Shetty -- Known Vaccine-Associated Adverse Events / B. A. Pahud -- Communicating Vaccine Risks and Benefits / Clea Sarnquist -- Vaccine Refusal: Perspectives from Pediatrics / Kody Moffatt, Clancy McNally -- The Anti-vaccine Movement: A Pharmacist's View / Jeffery Goad -- Antivaccinationism: Parental Viewpoint / Anna M. Johnson -- The Vaccine Misinformation Landscape in Family Medicine / Donald B. Middleton -- Vaccines: Boon or Bane--A Nurse's Outlook / Catherine O'Keefe -- The Controversy That Will Not Go Away: Vaccines and Autism / Archana Chatterjee, -- Thimerosal and Other Vaccine Additives / James H. Conway -- Perceived Risks from Live Viral Vaccines / Alice Pong, Mark Sawyer -- Can Vaccines Cause Cancer? / Ann-Christine Nyquist -- Autoimmunity, Allergies, and Asthma: A Relationship to Vaccines? / Harold C. Delasalas -- The Role of Public Health Ethics in Vaccine Decision Making: Insights from the Centers for Disease Control and Prevention / Leonard Ortmann -- Alternative Schedules: Why Not? / Michael J. Smith -- Influenza Vaccines and Guillain Barré Syndrome / Nandini Bakshi, James J. Sejvar -- Can Vaccines Cause Chronic Diseases? / Ann-Christine Nyquist -- Kawasaki Disease and Sudden Infant Death Syndrome: Any Connection to Vaccination? / Kari Neemann -- Political and Legal Issues in Vaccination / Linda K. Ohri -- The Media's Role in Vaccine Misinformation / Paola Dees -- Vaccines and the Internet / David M. Berman -- An International Perspective on Vaccine Safety / Rajib Dasgupta -- An Infection Prevention Perspective on Immunizations / Sharon Plummer -- Insights from Public Health: A Framework for Understanding and Fostering Vaccine Acceptance / Glen J. Nowak, Kate LaVail.
  • 2014 ScienceDirect
    Faustman, Denise.
  • 2010
    Schulz, Kenneth Randal; Davis, Mark M.; Levy, Ronald; Nolan, Garry P.; Utz, Paul J.
    IL-6 is a pleiotropic cytokine with roles in many areas of biology; it is also implicated in diseases associated with inflammation. To understand how a molecule is capable of diverse effects, one must understand how cells respond to it. In most published studies, the mechanism of IL-6 signaling has been evaluated in cell lines with limited biological relevance. In this study, phospho-specific flow cytometry and other techniques were used to look closely at IL-6 signaling in primary murine lymphocytes. Splenic T cells, but not B cells, exhibited a strong phospho-STAT1 response to IL-6 in addition to the universally observed STAT3 activation. Interestingly, when IL-6 dose was reduced, T cells exhibited a B cell-like signaling phenotype; they had no phospho-STAT1 response to IL-6. STAT3 had a greater affinity than STAT1 for gp130, the IL-6 signal transducer, which allows STAT3 to become activated when IL-6 is scarce. In our system, STAT1 played a dual role in gene transcription downstream of IL-6. In contrast with previous reports, phospho-STAT1 was required for expression of a subset of genes, which indicates that nature has the ability to create a STAT1 knockout-like condition by stimulating cells with a low level of IL-6. A novel inhibitory function of STAT1, which indicates a modality used to influence TH biasing capability of IL-6, was also discovered. This work gives insight as to how a single molecule, IL-6, affects the immune system, the central nervous system, and metabolism in such complex ways.
  • 2013 Springer
    Kutikhin, Anton G.; Brusina, Elena B.; Yuzhalin, Arseniy E.
    Will address an important, yet underrepresented, topic. The correlation between viruses and atherosclerosis has been a focal point of the authors work, for a number of years. This volume will explore the relationship between different viral strains and atherosclerosis. It will begin by describing the hypothesis and denoting the mechanisms of virus-driven atherosclerosis, then expanding on the subject by focusing on different virus strains from Herpes, to Epstein-Barr, to the triad of Hepatitis viruses, et al on a chapter-by-chapter basis. While there are books, albeit few, that cover particular viral strains and their relationship to cardiovascular diseases, this work will be unique in its scope by considering multiple strains of viruses, making it a repository of information on the topic; a truly comprehensive volume.
  • 2013 Springer Protocols
    Bailer, Susanne M.; Lieber, Diana.
    High-throughput yeast two-hybrid protocol to determine virus-host protein interactions / Hannah Striebinger, Manfred Koegl, and Susanne M. Bailer -- Analysis of protein-protein interactions using LUMIER assays / Sonja Blasche and Manfred Koegl -- Detection of protein interactions during virus infection by bimolecular fluorescence complementation / Stefan Becker and Jens von Einem -- Discovery of host-viral protein complexes during Infection / Daniell L. Rowles, Scott S. Terhune, and Ileana M. Cristea -- Screening for host proteins with pro- and antiviral activity using high-throughput RNAi / Samantha J. Griffiths -- High resolution gene expression profiling of RNA synthesis, processing, and decay by metabolic labeling of newly transcribed RNA using 4-thiouridine / Lars Dölken -- Isolation and characterization of pathogen-bearing endosomes enable analysis of endosomal escape and identification of new cellular cofactors of infection / Konstanze D. Scheffer, Ruth Popa-Wagner, and Luise Florin -- Computational Analysis of Virus-Host interactomes / Caroline C. Friedel -- Interspecies heterokaryon assay to characterize the nucleocytoplasmic shuttling of herpesviral proteins / Shuai Wang, Kezheng Wang, and Chunfu Zheng -- Detection of integrated herpesvirus genomes by fluorescence in situ hybridization (FISH) / Benedikt B. Kaufer -- Fast generation of stable cell lines expressing fluorescent marker molecules to study pathogen induced processes / Jens Bernhard Bosse, Jessica Ragues, and Harald Wodrich -- Determination of HSV-1 infectivity by plaque assay and a luciferase reporter cell line / Diana Lieber and Susanne M. Bailer -- Generation of a stable cell line for constitutive miRNA expression / Diana Lieber -- Applications for a dual fluorescent human cytomegalovirus in the analysis of viral entry / Kerstin Laib Sampaio, Gerhard Jahn, and Christian Sinzger -- High temporal resolution imaging reveals endosomal membrane penetration and escape of adenoviruses in real time / Ruben Martinez ... [et al.] -- Three-dimensional visualization of virus-infected cells by serial sectioning : an electron microscopic study using resin embedded cells / Martin Schauflinger, Clarissa Villinger, and Paul Walther -- 3D-tissue model for herpes simplex virus-1 infections / Ina Hogk, Steffen Rupp, and Anke Burger-Kentischer -- In vivo visualization of encephalitic lesions in herpes simplex virus type 1 (HSV-1) infected mice by magnetic resonance imaging (MRI) / Wali Hafezi and Verena Hoerr -- Detection of antigen-specific T cells based on intracellular cytokine staining using flow-cytometry / Tina Schmidt and Martina Sester -- Functional NK cell cytotoxicity assays against virus infected cells / Rebecca J. Aicheler and Richard J. Stanton -- Assessment of natural killer cell responses to human cytomegalovirus-infected macrophages / Zeguang Wu, Giada Frascaroli, and Thomas Mertens -- Analysis of cell migration during human cytomegalovirus (HCMV) infection / Stefania Varani and Giada Frascaroli -- Gene targeting in mice : a review / Hicham Bouabe and Klaus Okkenhaug -- Protocol for construction of gene targeting vectors and generation of homologous recombinant embryonic stem cells / Hicham Bouabe and Klaus Okkenhaug -- Measurement of mouse cytomegalovirus-induced interferon-[beta] with immortalized luciferase reporter cells / Evgenia Scheibe ... [et al.].
  • 2014 Future Med
    Buonaguro, Franco M.
    Virus-like particles in vaccine development / Franco M. Buonaguro & Luigi Buonaguro -- Developments in virus-like particle-based vaccines for HIV / Luigi Buonaguro, Maria Tagliamonte, Maria Luisa Visciano, Maria Lina Tornesello & Franco M Buonaguro -- Virus-like particle vaccines for the prevention of human papillomavirus infection / Joshua W. Wang, Richard B.S. Roden, Maria Lina Tornesello & Franco M. Buonaguro -- Virus-like particle-based vaccines against hepatitis C virus infection / Bertrand Bellier & David Klatzmann -- Evaluation of human rotavirus VLP vaccines in neonatal gnotobiotic pigs / Marli P. Azevedo, Anastasia N. Vlasova & Linda J. Saif -- Presenting heterologous epitopes with hepatitis B core-based virus-like particles / Sarah De Baets, Kenny Roose, Bert Schepens & Xavier Saelens -- SV40 virus-like particles as an effective delivery system and a vaccine platform / Masaaki Kawano, Masanori Matsui & Hiroshi Handa -- Plant-produced virus-like particle vaccines / Nunzia Scotti & Edward P. Rybicki -- Production of complex virus-like particles in insect cells / Fabiana Fernandes, Ana P. Teixeira, Nuno Carinhas, Manuel J.T. Carrondo & Paula M. Alves -- Index.
  • 2009 Springer
    Dustin, Mike; McGavern, Dorian.
    Two-photon imaging of the immune system: a custom technology platform for high-speed, multicolor tissue imaging of immune responses / Andrew Bullen, Rachel S. Friedman, and Matthew F. Krummel -- Visualizing intermolecular interactions in T cells / Nicholas R.J. Gascoigne ... [et al.] -- Multiscale analysis of T cell activation: correlating in vitro and in vivo analysis of the immunological synapse / Michael L. Dustin -- T cell migration dynamics within lymph nodes during steady state: an overview of extracellular and intracellular factors influencing the basal intranodal T cell motility / Tim Worbs and Reinhold Forster -- Chemoattractant receptor signaling and its role in lymphocyte motility and trafficking / John H. Kehrl, Il-Young Hwang, and Chung Park -- New insights into leukocyte recruitment by intravital microscopy / Alexander Zarbock and Klaus Ley -- Visualizing the molecular and cellular events underlying the initiation of B-cell activation / Naomi E. Harwood and Facundo D. Batista -- Tracking the dynamics of Salmonella specific T cell responses / James J. Moon and Stephen J. McSorley -- Imaging Listeria monocytogenes infection in vivo / Vjollca Konjufca and Mark J. Miller -- Inflammation on the mind: visualizing immunity in the central nervous system / Silvia S. Kang and Dorian B. McGavern -- Multiphoton imaging of cytotoxic T lymphocyte-mediated antitumor immune responses / Alexandre Boissonnas ... [et al.].
    Also available: Print – 2009
  • 2013 Springer
    Wick, W. David; Yang, Otto O.
    In the relatively few decades since the introduction of HIV into the human population, variants of the virus have diverged to such an extent that, were the discussion about something other than viruses, said variants could easily be classified as different species. This book will consider these evolutionary variations, as well as the different and, at times, opposing theories attempting to explain them. It will compare and contrast the ways in which the immune system and drugs affect the virus's evolution, and the implications of these for vaccine development. The issue will be explored and explained through "ecological genetics," which postulates that all living organisms have, besides rivals, enemies. This is divergent from the more traditional school of "population genetics," which emphasizes that evolution occurs among rival species (or variants thereof) that compete for niches or resources in a fixed, unreactive environment. Both models will be formulated using mathematical models, which will be included in the book. Finally, it will consider the possibilities for designing a vaccine that blocks HIV from escaping the immune system.
  • 2014 ebrary
    Anisman, Hymie; Kusnecov, Alexander W.
    The term psychoneuroimmunology was originally coined to acknowledge the existence of functional interactions between the brain, the immune system and the endocrine system. As our understanding deepens regarding the interplay between the brain and the way bodies function, the field continues to grow in importance.
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