Books by Subject

Allergy and Immunology

  • 2013From: ClinicalKey
    David Male [and others].
    This textbook teaches the basic and clinical immunology concepts.
  • 2013From: Springer
    Darren R. Flower, Yvonne Perrie, editors.
    This book seeks to expand the horizons of vaccine design and discovery by highlighting cutting edge work in three areas of vaccinology: the rational discovery of subunit vaccines, the identification of adjuvants, and the delivery of vaccines via state-of-the-art nanotechnology.
  • v. 2-, 2009-From: Springer
  • 2014From: CRCnetBASE
    edited by Bharat B. Aggarwal, David Heber.
    Chapter 1. Evolution of innate and adaptive immunity / David Heber and Bharat B. Aggarwal -- chapter 2. Cellular mechanisms of cytokine activation / David Heber and Bharat B. Aggarwal -- chapter 3. Cellular lipids and inflammation / David Heber and Susanne Henning -- chapter 4. Biomarkers of inflammation and the Western diet / David Heber and Susanne Henning -- chapter 5. Phytochemicals and immune function / David Heber -- chapter 6. Genetic and environmental modifiers of immune function / David Heber -- chapter 7. Cancer and inflammation / David Heber -- chapter 8. Abdominal obesity : pathophysiology and related metabolic complications / Ana F.T.A. Junqueria and Caroline M. Apovian -- chapter 9. Type 2 diabetes and inflammation / Zhaoping Li and David Heber -- chapter 10. Heart disease and inflammation / Kaveh Daniel Navab -- chapter 11. Chronic kidney disease and inflammation / Karl J. Neff and Carel Le Roux -- chapter 12. Alzheimer's disease and inflammation / Stephen T. Chen and Gary W. Small -- chapter 13. Nutrition in autoimmunity : a focus on systemic lupus erythematosus and rheumatoid arthritis / Maureen McMahon -- chapter 14. Asthma and inflammation / Andre Nel and David Heber -- chapter 15. Muscle and immune function / Anthony Thomas and David Heber -- chapter 16. Approaches to reducing abdominal obesity / Zhaoping Li and David Heber -- chapter 17. Barriers to fruit and vegetable consumption and practical strategies for increasing fruit and vegetable intake / Susan Bowerman -- chapter 18. Healthy fats and oils : balancing omega-3 and omega-6 acids in tissues / Bill Lands -- chapter 19. Spices and dietary supplements with anti-inflammatory activity / Bharat B. Aggarwal and David Heber.
  • 2008From: Springer
    Manzoor M. Khan.
  • 2017From: ScienceDirect
    edited by Virgil E.J.C. Schijns (Wageningen University, Wageningen, The Netherlands), Derek T. O'Hagan (GSK Vaccines, Rockville, MD, United States).
  • 2013From: Springer Protocols
    edited by Kelly M. Fulton, Susan M. Twine.
    Introduction to the immune system / Scott McComb ... [et al.] -- Immunoproteomics : current technology and applications / Kelly M. Fulton and Susan M. Twine -- Antigen identification using SEREX / Ugur Sahin and Özlem Türeci -- Antigen discovery using whole-genome phage display libraries / Elisa Beghetto and Nicola Gargano -- Methods and applications of serological proteome analysis / Kelly M. Fulton ... [et al.] -- Pre-absorbed immunoproteomics : a novel method for the detection of bacterial surface proteins / Guangjin Liu, Wei Zhang, and Chengping Lu -- Identification of the antigen content of electroimmunoprecipitates / N. Helena Beyer and Niels H.H. Heegaard -- Immunoproteomics approach to screen the antigenicity of the influenza virus / Kevin M. Downard -- In vivo microbial antigen discovery (InMAD) to identify diagnostic proteins and polysaccharides that are circulating during microbial infections / Sindy J. Chaves ... [et al.] -- Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies / Alexander Nøstdal and Hans H. Wandall -- Enrichment and characterization of glycopeptide epitopes from complex mixtures / Luc Tessier, Kelly M. Fulton, and Susan M. Twine -- Whole-cell MALDI-TOF mass spectrometry : a tool for immune cell analysis and characterization / Richard Ouedraogo ... [et al.] -- Cell-based arrays for the identification of interacting polypeptide domains or epitopes / Richard H. Maier, Christina J. Maier, and Kamil Önder -- Identification and quantitation of MHC class II-bound peptides from mouse spleen dendritic cells by immunoprecipitation and mass spectrometry analysis / Leonia Bozzacco and Haiqiang Yu -- Construction and screening of an antigen-derived peptide library displayed on yeast cell surface for CD4+ T cell epitope identification / Fei Wen and Huimin Zhao -- Profiling of cytokine and chemokine responses using multiplex bead array technology / Greg Harris and Wangxue Chen -- Preparation of the low molecular weight serum proteome for mass spectrometry analysis / Timothy J. Waybright ... [et al.] -- Identification of protein biomarkers in human serum using iTRAQ and shotgun mass spectrometry / Theodoros A. Koutroukides ... [et al.] -- Genome-based bioinformatic prediction of major histocompatibility complex (MHC) epitopes / Simon J. Foote -- Structure-based prediction of major histocompatibility complex (MHC) epitopes / Andrew J. Bordner -- Prioritization of therapeutic targets of inflammation using proteomics, bioinformatics, and in silico cell-cell interactomics / Arsalan S. Haqqani and Danica B. Stanimirovic -- Commercial considerations for immunoproteomics / Scott M. Ferguson.
  • 2015From: Springer Protocols
    edited by Albert C. Shaw.
    Isolation of lipid rafts from human neutrophils by density gradient centrifugation / Carl Fortin and Tamas Fülöp -- Flow cytometry analysis of NK cell phenotype and function in aging / Raquel Tarazona ... [et al.] -- Flow cytometric identification of fibrocytes in the human circulation / Xinyuan Hu, Erin M. DeBiasi, and Erica L. Herzog -- Experimental approaches to tissue injury and repair in advanced age / Aleah L. Brubaker, Stewart R. Carter, and Elizabeth J. Kovacs -- Multicolor digital flow cytometry in human translational immunology / Samit R. Joshi, Subhasis Mohanty, and Albert C. Shaw -- Flow cytometry-based methods to characterize immune senescence in nonhuman primates / Christine Meyer ... [et al.] -- Multiparameter phenotyping of human PBMCs using mass cytometry / Michael D. Leipold, Evan W. Newell, and Holden T. Maecker -- Imaging immunosenescence / Feng Qian and Ruth R. Montgomery -- Activation-induced cytidine deaminase and switched memory B cells as predictors of effective in vivo responses to the influenza vaccine / Daniela Frasca, Alain Diaz, and Bonnie B. Blomberg -- Analyzing the effect of aging on CD8+ T-cell phenotype using flow cytometry / Min Sun Shin and Insoo Kang -- Cell-mediated immune response to influenza using ex vivo stimulation and assays of cytokine and granzyme B responses / Janet E. McElhaney and Beth Gentleman -- Assays for monitoring macroautophagy activity in T cells / Yair Botbol and Fernando Macian -- Fluorescence-based approaches for quantitative assessment of protein carbonylation, protein disulfides, and protein conformation in biological tissues / Asish R. Chaudhuri ... [et al.] -- Monitoring the DNA damage response at dysfunctional telomeres / Rekha Rai and Sandy Chang -- Single-cell analysis of T-cell receptor Αβ repertoire / Pradyot Dash, George C. Wang, and Paul G. Thomas -- Assessment of B cell repertoire in humans / Yu-Chang Wu, David Kipling, and Deborah Dunn-Walters -- Laboratory and data analysis methods for characterization of human B cell repertoires by high-throughput DNA sequencing / Chen Wang ... [et al.] -- Discovery of novel microRNAs in aging Caenorhabditis elegans / Alexandre de Lencastre and Frank Slack -- Analysis of DNA methylation by pyrosequencing / Colin Delaney, Sanjay K. Garg, and Raymond Yung.
  • 2012From: Springer
    Andreas Thiel, editor.
  • 2013From: Springer
    Jos A. Bosch, Anna C. Phillips, Janet M. Lord, editors ; foreword by Keith W. Kelley.
    This book presents the first multi-disciplinary approach to the understanding of immune aging, or immunosenescence; it combines biological data and clinical observations with psychological, social, and behavioral perspectives and is thus a valuable and timely contribution to the literature in this area. Contributors, all eminent scholars in their respective fields, review thoroughly the state of the art in research that examines how psychological and behavioral factors influence the rate and extent of immune system aging.
  • 2017From: ScienceDirect
    Huangxian Ju, Guosong Lai, Feng Yan.
  • 2012From: Future Med
    editors, Yehuda Shoenfeld, Pier Luigi Meroni, Ricard Cervera.
    Immunotherapeutic agents for SLE / Yehuda Shoenfeld, Pier Luigi Meroni & Ricard Cervera -- Immunopathogenesis of SLE and drug targets / Arvind Kaul, David D'Cruz & Graham R.V. Hughes -- Rituximab in SLE / Cándido Díaz-Lagares, Manuel Ramos-Casals & Munther A. Khamashta -- Belimumab in SLE / Ricard Cervera & Gerard Espinosa -- Epratuzumab in SLE / David M. Goldenberg & Daniel J. Wallace -- Intravenous immunoglobulin therapy for SLE / Ziv Rozman & Gisele Zandman-Goddard -- Other novel immunotherapeutic agents in the pipeline and future directions / Ana M. Bertoli & Graciela S. Alarcón -- Index.
  • 2017From: Springer
    Aung Naing, Joud Hajjar, editors.
    "In the last decade, immunotherapy has revolutionized the practice of medicine in the field of oncology. This book, Immunotherapy, highlights the immunotherapeutic approaches currently in use and strategies to overcome the associated challenges. As comprehensive knowledge of basic immunology in the context of tumor biology is required to move further along the line of development in translational science, this book provides an overview of the cellular components of the immune system that interact with each other to provide a successful immune response. Immunotherapy offers promising antitumor activity across multiple cancer types as it does not attack the tumor but primarily revitalizes a suppressed immune system. It is beyond the scope of this book to discuss the immunotherapeutic approaches across the tumor board. However, the book features the role of immune-oncology in acute myeloid leukemia, non-small cell lung cancer, and sarcomas to showcase the recent advances in the management of cancer broadly classified as hematological malignancies, solid tumors, and tumors arising in the connective tissue. The book also discusses alternative formulations and combinatorial approaches to enhance the therapeutic index of these agents. As immunotherapeutic agents differ significantly from chemotherapeutic agents in response patterns and toxicity profiles, evaluating their safety and efficacy in clinical trials remains a challenge. In this book, we discuss the use of a variety of traditional and new immunotherapy criteria to evaluate response, their inadequacies, and clinical implications. The book also outlines how recent advances in medical imaging technology have the potential to provide high-dimensional data to improve decision support and individualize treatment selection and monitoring. Importantly, the book attempts to increase the awareness to immune related adverse events and the need for aggressive and judicious management of toxicities to improve treatment outcomes in patients on immunotherapy In short, this book provides a broad understanding of immunotherapy and ways to leverage the immune system to make inroads in the fight against cancer"--Publisher's description.
  • 2007From: Springer
    A. Radbruch ... [et al.], editors.
  • 2006From: Springer
    edited by Mary L. Disis.
    Discovery of target molecules for cancer immunotherapy by genetic and bioinformatic approaches -- Current strategies for the identification of immunogenic epitopes of tumor antigens -- Current and future role of natural-killer cells in cancer immunotherapy -- The role of immune monitoring in evaluating cancer immunotherapy -- Statistical analysis of immune response assays -- DNA vaccines for cancer immunotherapy -- Dendritic cells -- Different approaches to dendritic cell-based cancer immunotherapy -- Anti-idiotype antibody vaccines for the immunotherapy of cancer -- Autologous tumor-derived heat shock protein vaccine as a new paradigm for individualized cancer therapeutics -- Tumor-reactive T-cells for adoptive immunotherapy -- T-cell adoptive immunotherapy of cancer: from translational models to clinical significance -- Retroviral-mediated gene transfer for engineering tumor-reactive T-cells -- Harnessing the potential of graft-vs-tumor -- Tumor-induced immune suppression and immune escape: mechanisms and impact on the outcome of immunotherapy of malignant disease -- The tumor microenvironment: regulation of antitumor immunity and implications for immunotherapy -- Manipulation of lymphocyte homeostasis for enhancing antitumor immunity -- Fast-lane evolution in the tumor microenvironment -- Manipulating immunological checkpoints to maximize antitumor immunity -- Interleukin-2 as cancer therapy -- Biological and clinical properties of the type 1 interferons -- Promising g [gamma]-chain cytokines for cancer immunotherapy: interleukins-7, -15, and -21 as vaccine adjuvants, growth factors -- The therapeutic use of natural-killer cells in hematological malignancies -- Antibody therapy for solid tumors -- Antibody therapy for non-Hodgkin's lymphoma -- Approaches to in vivo imaging of cancer immunotherapy -- Design issues for early-stage clinical trials for cancer vaccines -- Monoclonal antibody therapy for cancer.
  • 2015From: ScienceDirect
    edited by Xiang-Yang Wang and Paul B. Fisher.
  • 2016From: Springer
    Yoshiyuki Yamaguchi, editor.
    Part I. Overview, history, classification -- Part II. BRMs and crude agents -- Part III. Adoptive cell therapy -- Part IV. Vaccine therapy -- Part V. Immunoadjuvants -- Part VI. Immunocheckpoints -- Part VII. Regulation of immunosuppression -- Part VIII. Immune-related response criteria and guidance for clinical trials -- Part IX. Personalized immunotherapy.
  • 2010From: Springer Protocols
    edited by Patricia Yotnda.
    Hypoxic tumors and their effect on immune cells and cancer therapy / Patricia Yotnda, Danli Wu, and Anna May Swanson -- Characterization of regulatory T cells in tumor suppressive microenvironments / Guangyong Peng -- Generation of cytotoxic T lymphocytes for immunotherapy of EBV-associated malignancies / Corey Smith and Rajiv Khanna -- Acquisition, preparation, and functional assessment of human NK cells for adoptive immunotherapy / Dean A. Lee, Michael R. Verneris, and Dario Campana -- Enhanced migration of human dendritic cells expressing inducible CD40 / Natalia Lapteva -- Differentiation of human embryonic stem cells into hematopoietic cells in vitro / Eun-Mi Kim and Nicholas Zavazava -- Gene therapy to improve migration of T cells to the tumor site / Antonio Di Stasi, Biagio De Angelis, and Barbara Savoldo -- Gene therapy to improve function of T cells for adoptive immunotherapy / Concetta Quintarelli, Barbara Savoldo, and Gianpietro Dotti -- Cytokine-FC fusion genes as molecular adjuvants for DNA vaccines / Daniel Hirschhorn-Cymerman and Miguel-Angel Perales -- Pharmacology of anti-CD3 diphtheria immunotoxin in CD3 positive T-cell lymphoma trials / Jung Hee Woo ... [et al.] -- Construction of human antibody gene libraries and selection of antibodies by phage display / Thomas Schirrmann and Michael Hust -- Identification of immunogenic peptides of the self-tumor antigen : our experience with telomerase reverse transcriptase / Xochitl Cortez-Gonzalez and Maurizio Zanetti -- Rescue, amplification, purification, and PEGylation of replication defective first-generation adenoviral vectors / Michael A. Barry, Eric A. Weaver, and Sean E. Hofherr -- Adenovirus-mediated interleukin (IL)-24 immunotherapy for cancer / Rajagopal Ramesh ... [et al.] -- Liposomes for gene transfer in cancer therapy / Nancy Smyth Templeton -- Oncolytic HSV as a vector in cancer immunotherapy / Hongtao Li and Xiaoliu Zhang -- Generation of chimeric T-cell receptor transgenes and their efficient transfer in primary mouse T lymphocytes / Linda J. Howland, Nicole M. Haynes, and Phillip K. Darcy -- Multi-walled carbon nanotube (MWCNT) synthesis, preparation, labeling, and functionalization / Babak Kateb ... [et al.] -- Cellular immunotherapy of cancer / Fatma V. Okur and Malcolm K. Brenner.
  • 2012From: Springer
    Rodney R. Dietert, Robert W. Luebke, editors.
    Immunotoxicity, Immune Dysfunction, and Chronic Disease is among the first books to illustrate the linkage between environmental risk factors (e.g., chemicals, drugs, diet, lifestyles), environmentally-induced immune dysfunction and the full range of resulting chronic diseases and conditions. There is a detailed discussion of specific immune-based chronic diseases and conditions that emerge in children and adults and affect different physiological systems. The book integrates a consideration of risk factors and specific immunotoxic alterations with disease outcomes. A significant number of diseases and conditions are discussed, such as systemic allergic diseases affecting the lung, skin and gastrointestinal tract, systemic autoimmune diseases (type 1 diabetes, multiple sclerosis and lupus) and chronic conditions that are not traditionally associated with chemically-mediated immunomodulation (depression, frailty, and atherosclerosis). Inflammatory dysregulation is a common thread that connects many of the diseases and conditions discussed in this book and provides a central focus. Individual chapters are organized by disease with the addition of chapters that provide integrative information on: 1) patterns of disease comorbidities and 2) the safety testing of chemicals and drugs to reduce the risk of immune dysfunction. Each chapter contains a summary of key points as well as recommendations when appropriate. The book stresses the benefits of identifying the environmental risk factors of immune-mediated chronic disease and the potential to reduce the prevalence of these diseases and conditions. This volume is a valuable resource for researchers, clinicians, risk assessors and regulators and students.
  • 2007From: CRCnetBASE
    edited by Robert Luebke, Robert House, and Ian Kim.
  • v.1, 2004From: ScienceDirect
    J. Descotes.
    v. 1. Principles and methods of immunotoxicology.
  • 2016From: Cambridge
    edited by Paul J. Beggs.
    The authoritative assessment of the many climate change impacts on allergens and allergic diseases, for researchers, clinicians, students.
  • 2007From: Springer
    edited by Darren Flower and Jon Timmis.
  • 2015From: ClinicalKey
    edited by Yehuda Shoenfeld, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, and Laura Schwarz-Kip Chair for Research of Autoimmune Diseases, Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Nancy Agmon-Levin, Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel Hashomer, affiliated with Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel, Noel R. Rose, Department of Pathology, Department of Molecular Microbiology and Immunology, the Center for Autoimmune Disease Research, the Johns Hopkins Schools of Medicine and Public Health, Baltimore, Maryland, USA.
  • 2012From: Springer
    Joan Stein-Streilein, editor.
    The Eye as a model for immune privilege -- Immune privilege of the testis: meaning, mechanisms, and manifestations -- The Role of intrauterine immune privilege in perinatal infectious diseases -- The Liver as an immune-privileged site -- Immune homeostasis of the lung: the role of regulatory NKT cells in asthma -- Immune homeostasis of the gut.
  • 2016From: Oxford Medicine Online
    edited by Pranatharthi H. Chandrasekar.
    Infections in cancer patients / editor, Alison G. Freifeld -- Infections in solid organ transplant recipients / editors, Ajit P. Limaye and Lynne Strasfeld -- Infections in hematopoietic stem cell transplant (HSCT) recipients / editor, John R. Wingard -- Infections in patients receiving immunosuppressive drugs / editor, Emily A. Blumberg -- Infections in patients with immunosuppression due to miscellaneous conditions / editors, George J. Alangaden, Prantharthi H. Chandrasekar.
  • 2013From: Springer Protocols
    edited by Christine M. De Nardo and Eicke Latz.
    Assessing [beta]-amyloid-induced NLRP3 inflammasome activation in primary microglia / Mareike Schnaars, Hannes Beckert, and Annett Halle -- Activating the NLRP3 inflammasome using the amyloidogenic peptide IAPP / Clara Westwell-Roper [and others] -- Assessment and quantification of crystal-induced lysosomal damage / Peter Duewell and Eicke Latz -- Assessment of inflammasome activation in primary human immune cells / Theo S. Plantinga, Leo A.B. Joosten, and Mihai G. Netea -- NLRP3 inflammasome activation and cytotoxicity induced by particulate adjuvants / Marie Yang [and others] -- Measuring inflammasome activation in response to bacterial infection / Petr Broz and Denise M. Monack -- Detection of pyroptosis by measuring released lactate dehydrogenase activity / Manira Rayamajhi, Yue Zhang, and Edward A. Miao -- ASC speck formation as a readout for inflammasome activation / Andrea Stutz [and others] -- Immunoblotting for active caspase-1 / Christopher Jakobs [and others] -- Inflammasome activation and inhibition in primary murine bone marrow-derived cells, and assays for IL-1[alpha], IL-1[beta], and caspase-1 / Katharina S. Schneider, Christina J. Thomas, and Olaf Gross -- Reconstituting the NLRP1 inflammasome in vitro / Benjamin Faustin and John C. Reed -- Assessing ATP binding and hydrolysis by NLR proteins / Jinyao Mo and Joseph A. Duncan -- Blue native polyacrylamide gel electrophoresis to monitor inflammasome assembly and composition / Eric M. Kofoed and Russell E. Vance -- Analysis of microbiota alterations in inflammasome-deficient mice / Eran Elinav, Christoph A. Thaiss, and Richard A. Flavell -- Quantification of adipose tissue leukocytosis in obesity / Ryan Grant [and others] -- In vivo evaluation of neutrophil recruitment in response to sterile particulates / Tamiko Yanagida, Kaoru Orihashi, and Hajime Kono.
  • 2016From: Springer
    edited by Steffen Backert, editor.
    This volume details our current understanding of the architecture and signaling capabilities of known canonical and non-canonical inflammasome complexes and highlights their action, in particular in response to infection with important bacterial model organisms and the corresponding disease pathologies. The first chapters review new insights into the assembly and structures of inflammasome components and emphasize general strategies of up- and downstream signaling events. In addition, the authors specifically discuss the composition and activity of inflammasomes during infection with various gut pathogens (Salmonella, Shigella, Yersinia, Listeria and Helicobacter), respiratory pathogens (Mycobacterium, Legionella, Burkholderia and Streptococcus) as well as skin and soft tissue pathogens (Francisella and Staphylococcus). The discoveries presented provide a better understanding of the cellular and molecular biology of inflammasomes, which will pinpoint important new therapeutic targets for the treatment and prevention of multiple infectious diseases in the future.
  • 2011From: Springer
    Isabelle Couillin, Virginie Pétrilli, Fabio Martinon, editors.
  • 2014From: ScienceDirect
    edited by Irfan Rahman, Debasis Bagchi.
    The book provides a comprehensive overview to understanding the integrated impact of the concepts of cellular and molecular aspects, models, environmental factors, and lifestyle involved in premature aging. Additionally, it examines how functional food, dietary nutraceuticals or pharmacological compounds can reverse inflammation and premature aging based on personalized medicine. This book is a valuable resource for health professionals, scientists and researchers, nutritionists, health practitioners, students and for all those who wish to broaden their knowledge in the allied field.
  • 2012From: Springer
    Georg Wick, Cecilia Grundtman, [editors].
    Ch. 1. Historical reflections on the inflammatory aspects of atherosclerosis -- Ch. 2. Morphology of atherosclerotic lesions -- Ch. 3. Clinical manifestations of atherosclerosis -- Ch. 4. Intra-aortic hematopoietic cells -- Ch. 5. The vascular-associated lymphoid tissue (VALT) -- Ch. 6. Vascular endothelial cells as immunological targets in atherosclerosis -- Ch. 7. The role of adhesion molecules and intimal dendritic cells in the initiation of atherosclerosis -- Ch. 8. Animal models of atherosclerosis -- Ch. 9. A Darwinian-evolutionary concept for atherogenesis: the role of immunity to HSP60 -- Ch. 10. Mediators of vascular inflammation -- Ch. 11. Pentraxins and atherosclerosis -- Ch. 12. Interleukin-33 and atherosclerosis -- Ch. 13. Proteomics of atherosclerosis -- Ch. 14. Adipokines, inflammation, and atherosclerosis -- Ch. 15. Natural antibodies and atherosclerosis -- Ch. 16. NK/NKT cells and atherosclerosis -- Ch. 17. Macrophages and atherosclerosis -- Ch. 18. Host pattern recognition receptors (toll-like receptors, RIG-I-Like receptors, NOD-like receptors) and atherosclerosis -- Ch. 19. Humoral antibodies -- Ch. 20. Adaptive T Cell immunity -- Ch. 21. Immunity to low-density lipoprotein -- Ch. 22. Extracellular matrix and smooth muscle cells -- Ch. 23. The role of infection in atherosclerosis and in plaque stability -- Ch. 24. Inflammatory biomarkers -- Ch. 25. Atherosclerosis in rheumatic diseases -- Ch. 26. Anti-inflammatory therapeutic approaches -- Ch. 27. Vaccination against atherosclerosis -- Ch. 28. Endocrinological aspects of atherosclerosis -- Ch. 29. Imaging of atherosclerosis -- Ch. 30. Future directions of atherosclerosis research and translation into clinical application -- Ch. 31. Controversies and open questions -- Index.
  • 2014From: Springer
    Bharat B. Aggarwal, Bokyung Sung, Subash Chandre Gupta, editors.
    The role of inflammation in lung cancer / Mónica Gomes, Ana Luísa Teixeira, Ana Coelho, António Araújo and Rui Medeiros -- The role of inflammation in colon cancer / Naveena B. Janakiram and Chinthalapally V. Rao -- The role of inflammation in inflammatory breast cancer / Tamer M. Fouad, Takahiro Kogawa, James M. Reuben and Naoto T. Ueno -- The role of inflammation in brain cancer / James L. Sowers, Kenneth M. Johnson, Charles Conrad, Joel T. Patterson and Lawrence C. Sowers -- The role of inflammation in head and neck cancer / Marcelo Bonomi, Alexis Patsias, Marshall Posner and Andrew Sikora -- The role of inflammation in pancreatic cancer / Simone Hausmann, Bo Kong, Christoph Michalski, Mert Erkan and Helmut Friess -- The role of inflammation in prostate cancer / Karen S. Sfanos, Heidi A. Hempel and Angelo M. De Marzo -- The role of inflammation in bladder cancer / Georgios Gakis -- The role of inflammation in kidney cancer / Antonio Roma De Vivar Chevez, James Finke and Ronald Bukowski -- The role of inflammation in gastric cancer / Kazim Senol, Murat Bulut Özkan, Selahattin Vural and Mesut Tez -- The role of inflammation in sarcoma / Jürgen Radons -- The role of inflammation in lymphoma / Antonino Carbone, Claudio Tripodo, Carmelo Carlo-Stella, Armando Santoro and Annunziata Gloghini -- The role of inflammation in leukaemia / Janusz Krawczyk, Michael O'Dwyer, Ronan Swords, Ciara Freeman and Francis J Giles -- The role of inflammatory cells in angiogenesis in multiple myeloma / Domenico Ribatti and Angelo Vacca -- The role of inflammation in cervical cancer / S. Deivendran, K. Hezlin Marzook and M. Radhakrishna Pillai -- The role of inflammation in liver cancer / Anupam Bishayee -- The role of inflammation in skin cancer / Girish B. Maru, Khushboo Gandhi, Asha Ramchandani and Gaurav Kumar.
    Also available: Print – 2014
  • v. 1-2, 2009From: Springer Protocols
    v. 2, 2009From: Springer Protocols
    edited by Serguei V. Kozlov.
    v. 1. Experimental models and practical approaches -- v. 2. Molecular analysis and pathways.
  • 2013From: Karger
    volume editors, A. Halaris, Maywood, Ill., B.E. Leonard, Galway.
    Basic aspects of the immunology of neuroinflammation / Wohleb, E.S.; Godbout, J.P. -- Stress and neuroinflammation / Grippo, A.J., Scotti, M.-A.L. -- Role of inflammation in depression : implications for phenomenology, pathophysiology and treatment / Raison, C.L., Miller, A.H. -- Virus infection as a cause of inflammation in psychiatric disorders / Bechter, K. -- Inflammation, neurotoxins and psychiatric disorders / Myint, A.-M. -- Essential fatty acids as potential anti-inflammatory agents in the treatment of affective disorders / Song, C. -- The brain-gut axis : a target for treating stress-related disorders / Scott, L.V., Clarke, G., Dinan, T.G. -- The question of pro-inflammatory immune activity in schizophrenia and the potential importance of anti-inflammatory drugs / Arolt, V., Ambrée, O. -- Inflammation as the cause of the metabolic syndrome in depression / Leonard, B.E. -- Glucocorticoids and inflammation : a double-headed sword in depression? / Horowitz, M.A. ... [et al.] -- Co-morbidity between cardiovascular pathology and depression : role of inflammation -- Halaris, A. -- Inflammatory and oxidative and nitrosative stress cascades as new drug targets in myalgic encephalomyelitis and chronic fatigue syndrome -- Maes, M. -- Peripheral inflammation and cognitive aging -- Lim, A., Krajina, K., Marsland, A.L. -- Inflammation in suicidality : implications for novel treatment options / Janelidze, S., Brundin, L.
  • 2012From: CRCnetBASE
    edited by Bharat B. Aggarwal, Sunil Krishnan, Sushovan Guha.
    "Oxidative stress and inflammation are among the most important factors of disease. Chronic infections, obesity, alcohol and tobacco usage, radiation, environmental pollutants, and high-calorie diets have been recognized as major risk factors for a variety of chronic diseases from cancer to metabolic diseases. All these risk factors are linked to chronic diseases through inflammation. While short-term, acute inflammation generated by the immune system serves a therapeutic role, chronic low-level inflammation that may persist "silently" for decades is responsible for chronic diseases. Inflammation, Lifestyle, and Chronic Diseases: The Silent Link describes the role of dysregulated inflammation in persistent and recurring diseases. It investigates links to lifestyle and presents research on how the suppression of proinflammatory pathways may provide opportunities for both prevention and treatment of chronic diseases. The book covers neurodegenerative diseases, pulmonary diseases, asthma, rheumatic and arthritic diseases, skin disease, heart disease, chronic wounds, infectious disease, neuropsychiatric disorders such as depression, gastrointestinal diseases, insulin resistance, and cancer, many of which are also diseases of old age. For each chronic disease, contributors review the clinical and scientific literature and examine current and potential therapies, including conventional pharmacotherapies as well as natural products. Noting that the long-term use of steroids and nonsteroidal anti-inflammatory drugs (NSAIDs) can cause adverse side effects, many of the chapters address the role of dietary agents such as fruits, vegetables, legumes, pulses, nuts, and spices as ideal anti-inflammatory agents that can be consumed regularly. The book also suggests directions for further research. Clinical and science researchers, students, and health professionals interested in the link between inflammation, lifestyle, and chronic diseases will find this an informative resource"--Provided by publisher.
  • 2012From: Wiley
    edited by Gary S. Hoffman, Cornelia M. Weyand, Carol A. Langford, Jörg J. Goronzy.
  • 2015From: Springer
    Mieczyslaw Pokorski, editor.
    The mechanistic basis of chronic inflammation remains unclear. The research sheds new light on the immune cells expressing the activation markers HLA-DR and regulatory T cells (Tregs) and the cells expressing Siglec receptors as being key players in the immune system responsiveness to antigens and thus in lung tissue damage of chronic inflammation. The results help understand the mechanisms of action of common drugs used in COPD, such as formoterol, tiotropium, or corticosteroids, and point to novel drug targets. The chapters also deal with brain damaging effects, by far unrecognized, of inhaled corticosteroid therapy, a time-proven management of chronic inflammatory airway conditions; asthma being a case in point. Novel methods, likely less producing side effects, of macrolide antibiotics administration by inhalation are discussed, emphasizing not only bacteriostatic but also anti-inflammatory action.
    Also available: Print – 2015
  • 2015From: Springer
    Michael Pugia, editor.
    Part 1. Introduction -- 1. Impact of inflammation and the innate immunity response in obesity mediated diabetes (lit review) -- Part 2. Impact of complement on diabetic disease -- 2. Complement and Complement Regulatory Proteins in Diabetes -- Part 3. Role of C terminal fragment of adiponectin receptor in inhibition of insulin degradation -- 3. Development of adiponectin receptor C terminal fragment bioassays -- 4. Protease inhibition and biological distribution of the C terminal fragment of adiponectin receptor -- 5. Cell & biological models for the C terminal fragment of adiponectin receptor -- 6. C-Terminal fragment of adiponectin receptor clinical correlations -- Part 4. Uristatin assay for prediction of renal and other clinical events -- 7. Uristatin immunoassay usage in glomerular nephritis assessment -- 8. Acute Response of Uristatin in Surgery -- 9. Cardiovascular and metabolic syndrome impact on uristatin -- 10. Uristatin anti-inflammatory cellular signaling -- Part 5. Summary -- 11. Overview of progress in new markers for diabetes inflammation (Literatue Review).
    Also available: Print – 2015
  • 2014From: Springer
    Richard W. Compans, Michael B.A. Oldstone, editors.
    This two-volume work covers the molecular and cell biology, genetics and evolution of influenza viruses, the pathogenesis of infection, resultant host innate and adaptive immune response, prevention of infection through vaccination and approaches to the therapeutic control of infection.. Experts at the forefront of these areas provide critical assessments with regard to influenza virology, immunology, cell and molecular biology, and pathogenesis. Volume I provides overviews of the latest findings on molecular determinants of viral pathogenicity, virus entry and cell tropism, pandemic risk assessment, transmission and pathogenesis in animal species, viral evolution, ecology and antigenic variation, while Volume II focuses on the role of innate and adaptive immunity in pathogenesis, development of vaccines and antivirals.
  • 2015From: Springer
    Michael B.A. Oldstone, Richard W. Compans, editors.
    Part I. Innate immunity. The role of cytokine responses during influenza virus pathogenesis and potential therapeutic options / John R. Teijaro -- Innate immune sensing and response to influenza / Bali Pulendran and Mohan S. Maddur -- The NS1 protein: a multitasking virulence factor / Juan Ayllon and Adolfo García-Sastre -- Role of NK cells in influenza infection / Stacey Shultz-Cherry -- Host detection and the stealthy phenotype in influenza virus infection / Pradyot Dash and Paul G. Thomas -- Part II. Vaccines and adaptive immunity. Inactivated and adjuvanted influenza vaccines / Giuseppe Del Giudice and Rino Rappuoli -- Live attenuated influenza vaccine / Hong Jin and Kanta Subbarao -- Design of alternative live attenuated influenza virus vaccines / Courtney Finch, Weizhong Li and Daniel R. Perez -- Rapid production of synthetic influenza vaccines / Philip R. Dormitzer -- Influenza neuraminidase as a vaccine antigen / Maryna C. Eichelberger and Hongquan Wan -- Advances in universal influenza virus vaccine design and antibody mediated therapies based on conserved regions of the hemagglutinin / Florian Krammer, Peter Palese and John Steel -- Structural characterization of viral epitopes recognized by broadly cross-reactive antibodies / Peter S. Lee and Ian A. Wilson -- Skin immunization with influenza vaccines / Ioanna Skountzou and Richard W. Compans -- Mucosal immunization and adjuvants / Hideki Hasegawa, Elly van Reit and Hiroshi Kida -- B cell responses to influenza infection and vaccination / Christopher Chiu, Ali H. Ellebedy, Jens Wrammert and Rafi Ahmed -- Memory CD4 T cells in influenza / Kyra D. Zens and Donna L. Farber -- The effector T cell response to influenza infection / Matthew M. Hufford, Taeg S. Kim, Jie Sun and Thomas J. Braciale -- Part III. New antiviral discovery. Antiviral effects of inhibiting host gene expression / Ralph A. Tripp and S. Mark Tompkins -- Index.
  • 2011From: Springer
    Rino Rappuoli, Giuseppe Del Giudice, editors.
    pt. 1. Evolution and epidemiology -- pt. 2. Immunity and vaccine strategies -- pt. 3. Economic and social implications.
  • Lori Katherine Phillips.
    Stem cells and their derivatives, engineered in vitro prior to transplantation or patterned endogenously by the environment following transplant, are hailed for their promise in treating numerous diseases, from heart disease to diabetes and arthritis. However, one substantial barrier to the success of such treatments is the effect of the immunological response on survival and function of the cells. To this end, the transplantation of neural progenitor cells (NPCs) into the healthy brain provides one of the most favorable situations for graft survival, since the central nervous system is an immune privileged site and NPC are immune privileged cells. Herein, we address whether major histocompatibility complex (MHC) mismatch results in the rejection of NPC grafts placed in the murine hippocampus and investigate which immune effectors affect graft outcome. These transplantation studies reveal that while some allogeneic cells survive, MHC incompatibility strongly inhibits the differentiation and retention of graft-derived as well as endogenously produced new neurons. We also demonstrate that inhibiting innate immune activation with non-steroidal anti-inflammatory drugs decreases observed microglial activation and restores allogeneic neuron production and retention to levels seen in syngeneic grafts. Additionally, we show that MHC and activating ligand expression profiles on NPC facilitates recognition by Natural Killer (NK) cells. We utilize animals deficient for critical innate and adaptive immune receptors to establish that both NK cells and T cells influence graft survival and differentiation. Finally, we evaluate how MHC expression intrinsically influences NPC arborization in vitro. Intriguingly, MHC deficiency results in longer and more extensively branched processes. Taken together, our data suggest that MHC expression on grafted NPC facilitates NPC interaction with multiple other cell types, and consequently cannot be ignored when considering NPC transplantation clinically. Indeed, clinical application of NPC will undoubtedly place these cells into injured or diseased brains, where immune barriers may be more substantial. However, these data provide a starting point for evaluation of appropriate immune modulation strategies for such transplants.
  • 2008From: Springer
    Eitan Yefenof, editor.
  • 2014From: Springer Protocols
    edited by Hans-Joachim Anders, Adriana Migliorini.
    Detection of RNA modifications by HPLC analysis and competitive ELISA / Gernot Nees, Andreas Kaufmann, and Stefan Bauer -- Enzymatic synthesis and purification of a defined RIG-I ligand / Marion Goldeck ... [et al.] -- Crystallization of mouse RIG-I ATPase domain : in situ proteolysis / Filiz Civril and Karl-Peter Hopfner -- Isolation of RIG-I-associated RNAs from virus-infected cells / Andreas Schmidt ... [et al.] -- Structure modeling of Toll-Like Receptors / Jing Gong and Tiandi Wei -- Nucleic acid recognition in dendritic cells / Alexander Heiseke, Katharina Eisenächer, and Anne Krug -- Viral nucleic acid recognition in human nonimmune cells : in vitro systems / Andrea Ribeiro and Markus Wörnle -- Analysis of nucleic acid-induced nonimmune cell death in vitro / Simone Romoli and Adriana Migliorini -- In vitro analysis of nucleic acid recognition in B lymphocytes / Saskia Ziegler and Isabelle Bekeredjian-Ding -- Mapping of optimal CD8 T cell epitopes / Julia Roider, Thomas Vollbrecht, and Rika Draenert -- Modular approach to suppression assays : TLR ligands, conditioned medium, and viral infection / Viktor H. Koelzer and David Anz -- MicroRNA methodology : advances in miRNA technologies/ Theresa Kaeuferle ... [et al.] -- Expression profiling by real-time quantitative polymerase chain reaction (RT-qPCR) / Maciej Lech and Hans-Joachim Anders -- Evaluating the role of nucleic acid antigens in murine models of systemic lupus erythematosus / Amanda A. Watkins, Ramon G. B. Bonegio, and Ian R. Rifkin -- Induction and analysis of nephrotoxic serum nephritis in mice / John M. Hoppe and Volker Vielhauer -- Isolation of intratumoral leukocytes of TLR-stimulated tumor-bearing mice / Moritz Rapp, David Anz, and Max Schnurr -- Bifunctional siRNAs for tumor therapy / Fanny Matheis and Robert Besch.
  • Yun Pei Sharon Goh.
    It has been proposed that allergic immune responses, like those mediated by type 2 immunity, evolved to protect the host from damage caused by environmental challenges, including toxins, xenobiotics, and helminth infections (1, 2). Despite some support for this hypothesis (3, 4), the underlying mechanisms by which type 2 innate responses orchestrate the regeneration of injured tissues remain largely unknown. Here, we demonstrate a requirement for type 2 innate immunity in regeneration of liver after partial hepatectomy and toxin-mediated injury. Injury to liver results in rapid recruitment of eosinophils, which secrete IL-4 to promote the proliferation of quiescent hepatocytes. Surprisingly, signaling via the IL-4R[alpha] in macrophages, which have been implicated in tissue repair (3-5), is dispensable for hepatocyte proliferation and liver regrowth after injury. Instead, IL-4 exerts its mitogenic actions by directly activating IL-4R[alpha] in hepatocytes. Our findings have thus uncovered an unexpected mechanism by which allergic type 2 innate immunity stimulates hepatocyte proliferation to promote liver regeneration.
  • 2012From: Springer
    Rong-Fu Wang, editor.
    "There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity. Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty. With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers."--Publisher's website.
  • Khoa Dinh Nguyen.
    Monophagocytes are a frontline defense against anything that should not be present in the body. Being highly mobile, they infiltrate almost every tissue to consume and dispose of material that might be damaging. To fight pathogens, monocytes and macrophages are transformed into pro-inflammatory machines that secrete catecholamines. However, monocytes and macrophages also exist in alternatively activated, anti-inflammatory forms that have a wide range of physiological roles. Unlike classically activated cells, which exhibit high pro-inflammatory potential, alternatively activated monocytes and macrophages (which are promoted by the TH2-type cytokines IL-4 and IL-13) are less pro-inflammatory and have distinct secretory and functional capacities. The inherent functional plasticity as well as the omnipresence of monocytes and macrophages in all tissues enables them to sense environmental changes. My dissertation will highlight two physiological settings in which, monocytes and macrophages, act as the sensors of perturbations in the environment to activate distinct physiological programs. The first part of my dissertation will discuss the role of adipose tissue alternatively activated macrophages in sensing changes in environmental temperature and its subsequent involvement in the maintenance of body temperature. The second part of my dissertation will provide evidences to show that inflammatory monocytes can sense change in the daily light dark cycle via their interaction with the circadian clock system to generate diurnal oscillation in monocyte-mediated inflammation.
  • 2008From: Springer Protocols
    edited by Jonathan Ewbank and Eric Vivier.
    ENU mutagenesis in mice / Philippe Georgel ... [et al.] -- Innate immunity genes as candidate genes : searching for relevant natural polymorphisms in databases and assessing family-based association of polymorphisms with human diseases / Pascal Rihet -- KIR locus polymorphisms : genotyping and disease association analysis / Maureen P. Martin and Mary Carrington -- Experimental model for the study of the human immune system : production and monitoring of "human immune system" Rag2-/[gamma]c-/- mice / Nicolas Legrand, Kees Weijer, and Hergen Spits -- Bacterial artificial chromosome transgenesis through pronuclear injection of fertilized mouse oocytes / Kristina Vintersten ... [et al.] -- Bioluminescence imaging to evaluate infections and host response in vivo / Pamela Reilly Contag -- Intravital two-photon imaging of natural killer cells and dendritic cells in lymph nodes / Susanna Celli, Béatrice Breart, and Philippe Bousso -- Dissection of the antiviral NK cell response by MCMV mutants / Stipan Jonjic ... [et al.] -- Analyzing antibody-Fc-receptor interactions / Falk Nimmerjahn and Jeffrey V. Ravetch -- The isolation and identification of murine dendritic cell populations from lymphoid tissues and their production in culture / David Vremec and Ken Shortman -- Analysis of individual natural killer cell responses / Wayne M. Yokoyama and Sungjin Kim -- Isolation and analysis of human natural killer cell subsets / Guido Ferlazzo -- Innate immune function of eosinophils : from antiparasite to antitumor cells / Fanny Legrand ... [et al.] -- Ex vivo and in vitro primary mast cells / Michel Arock ... [et al.] -- Murine macrophages : a technical approach / Luisa Martinez-Pomares and Siamon Gordon -- Clinical analysis of dendritic cell subsets : the dendritogram / Anne Hosmalin, Miriam Lichtner, and Stéphanie Louis -- Clinical analysis of human natural killer cells / Pascale André and Nicolas Anfossi -- Lentiviral transduction of immune cells / Louise Swainson ... [et al.] -- Axenic mouse model / Antoine Giraud -- In vivo analysis of zebrafish innate immunity / Jean-Pierre Levraud ... [et al.] -- Reverse genetics analysis of antiparasitic responses in the malaria vector, Anopheles gambiae / Stephanie A. Blandin and Elena A. Levashina -- Drosophila immunity : methods for monitoring the activity of toll and Imd signaling pathways / Yves Romeo and Bruno Lemaitre -- Investigating the involvement of host factors involved in intracellular pathogen infection by RNAi in Drosophila cells / Hervé Agaisse -- Models of Caenorhabditis elegans infection by bacterial and fungal pathogens / Jennifer R. Powell and Frederick M. Ausubel -- Genetic analysis of Caenorhabditis elegans innate immunity / Michael Shapira and Man-Wah Tan -- Measuring cell-wall-based defenses and their effect on bacterial growth in Arabidopsis / Min Gab Kim and David Mackey.
  • 2013From: Karger
    volume editors, Gunther Hartmann, Hermann Wagner.
    Microbiota's influence on immunity / Honda, K. ... [et al.] -- Inflammasomes and mucosal immune response / Elinav, E., Henao-Mejia, J., Flavell, R.A. -- Microbial endocrinology : an evolution-based shared mechanism determining microbiota's influence on health and disease / Lyte, M. -- Standing guard : innate lymphoid cells promote immunity and tissue homeostasis at barrier surface / Monticelli, L.A., Artis, D. -- miRNAs that shape the innate immune system : regulation through toll-like receptor signaling / Curtis, A.M., O'Neill, L.A. -- Type 2 diabetes and islet inflammation / Donath, M.Y. -- The innate immune system in Alzheimer's disease / Becker, H., Halle, A. -- Role of inflammasomes in obesity / Dixit, V.D. -- Gut-brain communication in the regulation of system metabolism / Miller, T.D., Pfliger, P.T., and Tschip, M.H. -- Metabolism and innate immunity : FOXO regulation of antimicrobial peptides in drosophila / Loch, G. ... [et al.] -- Dendritics cells orchestrate innate immunity agains bacterial kidney infection / Tittel, A.P. ... [et al.].
  • 2008From: Springer
    edited by Holger Heine.
    Evolution of resistance genes in plants / Shunyuan Xiao, Wenming Wang, Xiaohua Yang -- The path less explored: innate immune reactions in Cnidarians / Thomas C. G. Bosch -- Bug versus bug : humoral immune responses in Drosophila melanogaster / Deniz Ertürk-Hasdemir ... [et al.] -- Cellular immune responses in Drosophila melanogaster / Adrienne Ivory, Katherine Randle, Louisa Wu -- Immune reactions in the vertebrates' closest relatives, the urochordates / Konstantin Khalturin, Ulrich Kürn, Thomas C. G. Bosch -- Innate immune system of the zebrafish, Danio rerio / Con Sullivan, Carol H. Kim -- Toll-like receptors in the mammalian innate immune system / Andrei E. Medvedev, Stefanie N. Vogel -- NLRs : a cytosolic armory of microbial sensors linked to human diseases / Mathias Chamaillard -- Antimicrobial peptides as first-line effector molecules of the human innate immune system / Regine Gläser, Jürgen Harder, Jens-Michael Schröder -- The complement system in innate immunity / K. R. Mayilyan ... [et al.].
  • 2012From: Springer
    Selene Baschieri, editor.
    Prevention of infectious diseases by vaccination is one of the most significant achievements of modern medicine. During the 20th century, the average human life span in the developed world was about 70 years and it is expected to increase, with a significant portion of this increase directly attributed to vaccination. Since the first empiric vaccination trials, knowledge and technology have enormously evolved and new vaccination strategies are emerging on the market. Indeed, in spite of the great success, conventional vaccination strategies sometimes may result ineffective and, above all, may
  • 2007From: ScienceDirect
    edited by David A. Cheresh.
    Also available: Print – 2007
  • 2014From: Springer
    Magdalena Klink, editor.
    The tumor environment is a dynamic network that includes cancer cells, immune cells, fibroblasts, endothelial cells, extracellular matrix, cytokines and receptors. The aim of this book is to summarize the role of these components, especially immune cells, in tumor suppression and/or progression and describe in detail why tumor cells can survive and spread in spite of the antitumor response of immune cells. Since immunotherapy is an attractive approach to cancer therapy, this book also provides information on the two main strategies: monoclonal antibodies and adaptive T cell immunotherapy, with a focus on recent human clinical trials. The book provides a state-of-the-art, comprehensive overview of immune cells in cancer and is an indispensable resource for scientists and medical doctors working and/or lecturing in the field of cancer research and immunology.
  • 2007From: Springer
    Paula M. Pitha, ed.
    Also available: Print – 2007
  • 2005From: Springer Protocols
    edited by Daniel J.J. Carr.
    Also available: Print – 2005
  • 2014From: Springer
    Simon Fillatreau, Anne O'Gara, editors.
    " This volume provides a set of reviews dedicated to the biology of Interleukin (IL)-10. It includes chapters on its importance for maintaining immune homeostasis in humans, its role in intestinal immunity and its functions during viral and bacterial infections. In addition, it presents reviews on the mechanisms linking innate microbial recognition to the production of IL-10 and on how IL-10 recognition by its receptor functions. The roles of T and B cells as relevant sources of IL-10 are also discussed, with an emphasis on the clinical opportunities offered by IL-10-producing Tr1 cells for the suppression of unwanted immunity. Finally, the functions of other cytokines of the IL-10 family are presented. Collectively, these articles provide a comprehensive overview of our current knowledge on one of the most important anti-inflammatory cytokines known to date."--Publisher's website.
  • 2014From: ScienceDirect
    Arseniy E. Yuzhalin, Anton G. Kutikhin.
    Introduction : basic concepts -- Interleukin-1 superfamily and cancer -- Interleukin-2 superfamily and cancer -- Interleukin-3, Interleukin-5, and cancer -- IL-6 family and cancer -- Interleukin-10 superfamily and cancer -- Interleukin-12 superfamily and cancer -- Interleukin-17 superfamily and cancer -- The rest of interleukins -- Concluding remarks.
  • 2012From: Springer
    Marcel B.M. Teunissen, editor.
    Understanding the murine cutaneous dendritic cell network to improve intradermal vaccination strategies -- Insight into the immunobiology of human skin and functional specialization of skin dendritic cell subsets to innovate intradermal vaccination design -- Delivery systems for intradermal vaccination -- Targeting skin dendritic cells to improve intradermal vaccination -- Intradermal rabies vaccination : the evolution and future of pre- and post-exposure prophylaxis -- Intradermal vaccination to protect against yellow fever and influenza -- The dermis as a portal for dendritic cell-targeted immunotherapy of cutaneous melanoma -- DNA vaccines and intradermal vaccination by DNA tattooing
  • 2013From: Springer
    Bryan R. Cullen, editor.
    The APOBEC3 Family of Retroelement Restriction Factors / Eric W. Refsland, Reuben S. Harris -- Inhibition of Retroviral Replication by Members of the TRIM Protein Family / Adam J. Fletcher, Greg J. Towers -- The Antiviral Activities of Tetherin / Stuart J. D. Neil -- Restriction of Retroviral Infection of Macrophages / Mark Sharkey -- Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors / Welkin E. Johnson -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants / György Szittya, József Burgyán -- RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates / Arabinda Nayak, Michel Tassetto, Mark Kunitomi, Raul Andino -- Roles of MicroRNAs in the Life Cycles of Mammalian Viruses / Eva Gottwein -- Interplay Between DNA Tumor Viruses and the Host DNA Damage Response / Karyn McFadden, Micah A. Luftig.
  • 2012From: ScienceDirect
    Jorge H. Daruna.
    Historical antecedents -- Immune system basics -- Endocrine-immune modulation -- Neuroimmune modulation -- Stress, contextual change, and disease -- Psychosocial stress: neuroendocrine and immune effects -- Infection, allergy, and psychosocial stress -- Cancer, autoimmunity, and psychosocial stress -- Immune activity and psychopathology -- Immune function enhancement -- Integration and implications.
  • 2010From: Springer
    edited by Kenneth Söderhäll.
    Cnidarian immunity : a tale of two barriers / René Augustin and Thomas C.G. Bosch -- Gastropod immunobiology / Eric S. Loker -- Bivalve immunity / Linsheng Song [and others] -- Earthworm immunity / Martin Bilej [and others] -- Leech immunity : from brain to peripheral responses / Aurélie Tasiemski and Michel Salzet -- Innate immunity in C. elegans / Ilka Engelmann and Nathalie Pujol -- Immunocompetent molecules and their response network in horseshoe crabs / Shun-ichiro Kawabata -- Tick innate immunity / Petr Kopáček [and others] -- Beetle immunity / Ji-Won Park [and others] -- Immunity in Lepidopteran insects / Haobo Jiang, Andreas Vilcinskas, and Michael R. Kanost -- Fly immunity : recognition of pathogens and induction of immune responses / Shoichiro Kurata -- Mosquito immunity / Julián F. Hillyer -- Crustacean immunity / Lage Cerenius [and others] -- Echinoderm immunity / L. Courtney Smith [and others] -- Urochordate immunity barriers / Masaru Nonaka and Honoo Satake.
    Also available: Print – 2010
  • 2005From: CRCnetBASE
    edited by Helen Tryphonas, Michel Fournier, Barry R. Blakley ... [et al.].
    Also available: Print – 2005
  • 2005From: Springer
    by Gideon Berke and William R. Clark.
    Also available: Print – 2005
  • Yann Chong Tan.
    Despite tremendous progress in understanding immune responses, the ability to characterize functional antibody responses remains limited. I developed a method that utilizes barcoding to enable high-throughput sequencing of paired heavy-chain and light-chain immunoglobulin sequences. This approach enables us to generate dendrograms of functional affinity-matured antibody responses, and express selected antibodies for functional characterization. This method was applied to a human who received an influenza vaccine, humans with Staphylocuccus aureus infection, a human with rhuematoid arthritis, an autoimmune disease, and a human who has lung adenocarcinoma, and is a long term non-progressor. These are examples in vaccination, infection, autoimmune disease and cancer, respectively. In each case, we show that we were able to obtain paired heavy and light chain sequences. We expressed selected antibodies for functional characterization and showed that we were able to obtain functional antibodies that bound to target antigens in each of the above indications. Furthermore, we also showed that large clonal families dominate in influenza vaccination, and that larger antibody clonal families have higher binding affinities. Taken together, the approach provides a method to directly characterize functional antibody responses that could advance our understanding of protective and pathogenic immune responses in health and disease.
  • 2013From: Springer
    Awanish Kumar.
    Leishmania-related illnesses remain among the world s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
  • 2016From: Cambridge
    edited by Runjan Chetty, the Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada, Kumarasen Cooper, University of Pennsylvania Hospital, Philadelphia, PA, USA, Allen Gown, PhenoPath Laboratories, Seattle, WA, and University of British Columbia, Vancouver, BC, Canada.
    "Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees"-- Provided by publisher.
  • 2015From: Springer
    Ben Adler, Editor.
    This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world?s most widespread zoonosis. Topics include aspects of human and animal leptospirosis as well as detailed analyses of our current knowledge of leptospiral structure and physiology, epidemiology, pathogenesis, genomics, immunity and vaccines. Updates are presented on leptospiral systematics, identification and diagnostics, as well as practical information on culture of Leptospira. Contact information is also provided for Leptospira reference centers. All chapters were written by experts in the field, providing an invaluable reference source for scientists, veterinarians, clinicians and all others with an interest in leptospirosis.
  • 2012From: Springer Protocols
    edited by Robert B. Ashman.
    ENU-based phenotype-driven screening / Vera M. Ripoll, Philip L. Kong, and Paul K. Potter -- Detection and quantification of cytokines and other biomarkers / Evan L. Chiswick ... [et al.] -- Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells / Valérie Barbier ... [et al.] -- Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo / Valérie Barbier ... [et al.] -- Analyzing cell death events in cultured leukocytes / Karin Christenson, Fredrik B. Thorén, and Johan Bylund -- Towards a four-dimensional view of neutrophils / Ben A. Croker, Andrew W. Roberts, and Nicos A. Nicola -- Isolation of human and mouse neutrophils ex vivo and in vitro / Yan Hu -- Measurement of oxidative burst in neutrophils / Yu Chen and Wolfgang G. Junger -- Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates / Brice Korkmaz ... [et al.] -- The macrophage / Chris P. Verschoor, Alicja Puchta, and Dawn M.E. Bowdish -- Generation and characterization of MacGreen mice, the CFS1R-EGFP transgenic mice / R. Tedjo Sasmono and Elizabeth Williams -- Generation of mouse bone marrow-derived macrophages / Silvia Manzanero -- Isolation and differentiation of monocytes-macrophages from human blood / Dipti Vijayan -- In vitro measurement of phagocytosis and killing of Cryptococcus neoformans by macrophages / André Moraes Nicola and Arturo Casadevall -- Measuring the inflammasome / Olaf Gross -- Arginine and macrophage activation / Mònica Comalada -- Immunodetection of granzyme B tissue distribution and cellular localisation / Catherina H. Bird ... [et al.] -- Detection of human and mouse granzyme B activity in cell extracts / Sarah Elizabeth Stewart ... [et al.] -- T cell transfer model of colitis : a great tool to assess the contribution of T cells in chronic intestinal inflammation / Rajaraman Eri, Michael A. McGuckin, and Robert Wadley -- Measurement of nitrite in urine by gas chromatography-mass spectrometry / Dimitrios Tsikas ... [et al.].
  • 2016From: Springer
    edited by Dieter Steinhilber, editor.
    Oxidation of polyunsaturated fatty acids by lipoxygenases leads to a variety of fatty acid metabolites which play important roles in physiology but also in pathophysiology. Data accumulated during the last decade point to the fact that lipoxygenase metabolites are involved in host defence reactions, cardiovascular system and contribute to the development of inflammatory and allergic diseases, cardiovascular disease and cancer. This PIR volume summarizes the physiological and pathophysiological functions of lipoxygenases.
    Also available: Print – 2016
  • 2003From: Karger
    volume editors: Udo R. Markert, Peter Elsner.
    Also available: Print – 2003
  • 2015From: Springer
    Mieczyslaw Pokorski, editor.
    Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.
    Also available: Print – 2015
  • 2011From: Springer
    Stefan E. Pambuccian, Ricardo H. Bardales.
    Introduction -- Overview of ancillary methods in lymph node FNA diagnosis -- Lymphadenopathy: anatomic and clinical clues to fine needle aspiration diagnosis -- Cytology of normal/reactive lymph nodes -- Overall assessment of the aspirate: diagnostic clues -- Overview of the algorithmic pattern-based approach to lymph node FNA -- The polymorphous lymphoid cell pattern -- The monotonous small-cell pattern -- The monotonous intermediate-sized cell pattern -- The monotonous large cell pattern -- The pleomorphic cell pattern -- Infectious and noninfectious lympadenitis -- Unusual neoplastic and nonneoplastic conditions of lymph nodes -- Pitfalls and limitations of FNA of lymph nodes.
  • 2016From: Springer
    Trilok Chandra Goel, Apul Goel.
    Part I: Parasitology Including General Discussion -- History -- Epidemiology -- Etiology -- Lymphatic System -- Pathology of Lymphatic Filariasis -- Clinical Features -- Investigations -- Treatment and Prognosis -- Prevention and Control -- Antifilarial Drugs -- Clinical Manifestations of Filariasis -- Part II: Acute Clinical Manifestations -- Filarial Fever -- Acute Filarial Lymphangitis (AFL) -- Acute Lymphadenitis (ADL) -- Acute Dermatolymphangioadenitis (ADLA) -- Filarial Funiculitis -- Filarial Epididymo-orchitis -- Filarial Cellulitis-abscess -- Part III: Chronic Clinical Manifestations -- Hydrocele of Tunica Vaginalis Testis -- Chronic Lymphedema-elephantiasis -- Chronic Lymphedema-elephantiasis of Lower Extremity -- Chronic Lymphedema-elephantiasis of Scrotum -- Chronic Lymphedema-elephantiasis of Penis -- Chronic Lymphedema-elephantiasis of Upper Extremity -- Filarial Manifestations of Female Breast -- Chronic Lymphedema-elephantiasis of Vulva -- Filarial Lymph Varix -- Lymph Scrotum (Superficial Scrotal Lymphangiomatosis) -- Chylous Manifestations (Syndromes) of Lymphatic Filariasis (Filarial Chylous Disease) -- Chyluria -- Chylous Ascites: Chyloperitoneum -- Chylocele -- Chylothorax -- Chylous Diarrhea -- Chylous Arthritis (Filarial Arthropathy) -- Chylo-lymphatic Cyst -- Eosinophilia in Lymphatic Filariasis -- Filarial Hematuria -- Very Rare Manifestations -- Brugia Timori Filariasis -- Summary.-References -- Index.
  • 2011From: Springer
    Byung-Boong Lee, John Bergan, Stanley G. Rockson, editors.
    Primary Lymphedema as a Truncular Lymphatic Malformation -- Primary Lymphedema and Klippel-Trénaunay Syndrome -- Special Issues in Pediatric Primary Lymphedema -- Medical Management -- Surgical Management -- Epidemiology -- Etiology and Pathophysiology -- Clinical Overview-Diagnosis and Management -- Genetic Prospects for Lymphedema Management -- Breast Cancer -- Lower Extremity Cancers -- Radiation Complications -- Pathophysiology of Phlebolymphedema and a Physiologic Approach to Chronic Veno-lymphatic Insufficiency' -- Diagnosis and Management of Primary Phlebolymphedema -- Diagnosis and Management of Secondary Phlebolymphedema -- Management of Phlebolymphedema Ulcers -- Lymphedema Management by the Therapists -- Education of the Patient -- Patient/Family Advocacy -- Reimbursement of CDT-based Care -- General Considerations -- Etiology and Classification of Lymphatic Disorders -- Hereditary and Familial Lymphedema -- Embryology of the Lymphatic System and Lymphangiogenesis -- Anatomy of the Lymphatic System and Its Disorders -- Physiology, Pathophysiology, and Lymphodynamics: General Overview -- Lymphedema -- Physiology, Biology, and Lymph Biochemistry -- Physiology - Lymph Flow -- Pathology and Histochemistry -- Clinical Diagnosis: General Overview -- Clinical Staging -- Combined Clinical and Laboratory (Lymphoscintigraphic) Staging -- Early Diagnosis in Latent Phase -- Review of National and International Consensuses on Chronic Lymphedema -- Differential Diagnosis - General Considerations -- Differential Diagnosis - Lipedema -- Laboratory/Imaging Diagnosis: General Guidelines -- Radionuclide Lymphoscintigraphy -- Duplex Ultrasonography -- Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease -- Oil Contrast Lymphangiography -- Fluorescent Microlymphangiography -- Alternative Assessment and Measurement Tools -- Infection -- Physiological Principles of Physiotherapy -- Complete Decongestive Therapy -- Manual Lymph Drainage (Földi Method) -- Manual Lymph Drainage (Leduc Method) -- Compression Therapy -- Intermittent Pneumatic Compression Therapy -- Other Contemporary Treatment Modalities -- Medical Treatment -- Lower Limb Lymphedema -- Upper Limb Lymphedema -- Head and Neck Lymphedema -- Genital Lymphedema -- Psychological Aspect: Compliance and Quality of Life -- General Overview - Historical Background -- General Principles and Indications -- Lymphatic-Venous Derivative and Reconstructive Microsurgery -- Lymphatic-Lymphatic Reconstructive Microsurgery -- Lymph Node-Venous Microvascular Reconstructive Surgery: Filariasis Lymphedema -- Lymph Nodes Transfer Microvascular Reconstructive Surgery -- Current Dilemmas and Controversy -- Prospects for Lymphatic Reconstructive Surgery -- Historical Background - General Overview -- General Principles -- Contemporary Indications and Controversies -- Surgical Treatment of Postmastectomy Lymphedema - Liposuction -- Epilogue.
  • 2015From: Springer
    Arin K. Greene, Sumner A. Slavin, Håkan Brorson, editors.
    This volume is a clinically-oriented book that can be used for patient care, teaching, or research. It covers the entire field of lymphedema, including both primary and secondary disease, as well as all diagnostic and treatment modalities. The text begins with a foundation for the condition, including its pathophysiology, epidemiology, and morbidity. Next, the classification of lymphedema is covered which is the template for accurate diagnosis. Clinical, radiological, and differential diagnosis of lymphedema is also reviewed. Finally, conservative and operative management is presented, including both physiologic and excisional procedures. Lymphedema: Presentation, Diagnosis, and Treatment provides a comprehensive, easy-to-read reference for any health care provider managing a patient with lymphedema. The text is clinically-focused, evidence-based, and practical. The reader, regardless of his/her level of training or specialty, will be able to adequately treat a patient with lymphedema using this resource. To facilitate its use in clinical settings, the book was designed to be portable. In addition, diagnostic and treatment algorithms are included to further simplify the management of these patients. Patient images are presented throughout the text to illustrate the clinical care of lymphedema. All chapters are written by experts in the field, and contain the most current information on the topic.
  • 2008From: Springer
    Lawrence Tretbar ... [et al.].
  • 2006From: Springer
    Raffaele Badolato, Silvano Sozzani, editors.
    Also available: Print – 2006
  • 2013From: Springer Protocols
    edited by Ralf Küppers.
    Origin and pathogenesis of B cell lymphomas / Marc Seifert, René Scholtysik, and Ralf Küppers -- Flow cytometry for non-Hodgkin and classical Hodgkin lymphoma / David Wu, Brent L. Wood, and Jonathan R. Fromm -- Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells / Ralf Küppers, Markus Schneider, and Martin-Leo Hansmann -- PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by genescan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics / Elke Boone, Brenda Verhaaf, and Anton W. Langerak -- Expression cloning of human B cell immunoglobulins / Hedda Wardemann and Juliane Kofer -- Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR / Menno C. van Zelm, Magdalena A. Berkowska, and Jacques J.M. van Dongen -- Detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies / Martin J.S. Dyer -- Stereotyped B cell receptors in B cell leukemias and lymphomas / Nikos Darzentas and Kostas Stamatopoulos -- Flow cytometric MRD detection in selected mature B-cell malignancies / Sebastian Böttcher, Matthias Ritgen, and Michael Kneba -- MRD Detection in B-cell non-hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR / Christiane Pott [and others] -- Enrichment of methylated DNA by methyl-CpG immunoprecipitation / Miriam Sonnet [and others] -- Gene expression profile analysis of lymphomas / Katia Basso and Ulf Klein -- FISH and FICTION to detect chromosomal aberrations in lymphomas / Maciej Giefing and Reiner Siebert -- Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens / Vu N. Ngo -- Studying microRNAs in lymphoma / Joost Kluiver, Izabella Slezak-Prochazka, and Anke van den Berg -- Molecular methods of virus detection in lymphoma / Ruth F. Jarrett, Alice Gallagher, and Derek Gatherer -- High-throughput RNA sequencing in B-cell lymphomas / Wenming Xiao [and others].
  • 2014From: Cambridge
    edited by Robert Marcus, John W. Sweetenham, Michael E. Williams.
    Epidemiology / Eve Roman and Alexandra G. Smith -- Prognostic factors for lymphomas / Guillaume Cartron and Philippe Solal-Celigny -- Imaging / Heok K. Cheow and Ashley S. Shaw -- Clinical trials in lymphoma / Thomas M. Habermann and Matthew Maurer -- Hodgkin lymphoma / Stephanie Sasse and Andreas Engert -- Follicular lymphoma / Kristian Bowles, Daniel Hodson, and Robert Marcus -- MALT and other marginal zone lymphomas / Emanuele Zucca and Francesco Bertoni -- Small lymphocytic lymphoma/chronic lymphocytic leukemia / Peter Hillmen -- Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma / Steven P. Treon and Giampaolo Merlini -- Mantle cell lymphoma / Martin Dreyling and Michael E. Williams -- Burkitt and lymphoblastic lymphoma : clinical therapy and outcome / Nirali N. Shah, Alan S. Wayne, and Wyndham H. Wilson -- Therapy of diffuse large B-cell lymphoma / John W. Sweetenham -- Central nervous system lymphomas / Andres J.M. Ferreri and Lisa M. DeAngelis -- T-cell non-Hodgkin lymphoma / Sheetal M. Kircher [and others] -- Primary cutaneous lymphoma / Sean Whittaker -- Lymphoma in the immunosuppressed / Michele Spina [and others] -- Atypical lymphoproliferative, histiocytic, and dentritic cell disorders / Matthew S. Davids and Jennifer R. Brown.
  • Malgorzata Kloc, editor.
    Evolutionary Aspects of Macrophages Polarization / Eva-Stina Edholm, Kun Hyoe Rhoo, and Jacques Robert -- Development and Functional Differentiation of Tissue-Resident Versus Monocyte-Derived Macrophages in Inflammatory Reactions Paola Italiani and Diana Boraschi -- Hofbauer Cells: Placental Macrophages of Fetal Origin / Leticia Reyes, Bryce Wolfe, and Thaddeus Golos -- Mesenchymal Stem Cells Direct the Immunological Fate of Macrophages / Patricia Luz-Crawford, Christian Jorgensen, and Farida Djouad -- Monocyte/Macrophage: NK Cell Cooperation--Old Tools for New Functions / Elżbieta Wałajtys-Rode and Jolanta M. Dzik -- Macrophages in Invertebrates: From Insects and Crustaceans to Marine Bivalves / Prasad Abnave, Xavier Muracciole, and Eric Ghigo -- F4/80 as a Major Macrophage Marker: The Case of the Peritoneum and Spleen / Alexandra dos Anjos Cassado -- Immunobiology of Nitric Oxide and Regulation of Inducible Nitric Oxide Synthase / Martin Lee [and others] -- Role for Mechanotransduction in Macrophage and Dendritic Cell Immunobiology / Svenja F. B. Mennens, Koen van den Dries, and Alessandra Cambi -- Macrophages' Role in Tissue Disease and Regeneration / Lewis Gaffney [and others] -- Macrophages and Their Contribution to the Development of Atherosclerosis / Yuri V. Bobryshev [and others] -- Macrophage Dysfunction in Respiratory Disease / Kylie B. R. Belchamber and Louise E. Donnelly -- Activation of Macrophages in Response to Biomaterials / Jamie E. Rayahin and Richard A. Gemeinhart -- Macrophage Differentiation in Normal and Accelerated Wound Healing / Girish J. Kotwal and Sufan Chien -- Macrophages and RhoA Pathway in Transplanted Organs / Yianzhu Liu [and others].
  • 2014From: CRCnetBASE
    editors, Gary C. Howard and Matthew R. Kaser.
    "This second edition provides guidance on all aspects of how to make and use antibodies for research, and commercial and industrial applications. All chapters are revised, updated, or expanded. New material in the book includes western blotting, aptamers, antibodies as therapeutics, quantitative production, and humanization of antibodies. The authors present descriptions of basic methods for making and using antibodies and describe basic laboratory techniques in detail. Each chapter includes introductory material, allowing for a better understanding of each concept. Practical examples are also included"--Provided by publisher.
  • 2002From: Karger
    volume editors, Peter Perlmann, Marita Troye-Blomberg.
    pt. 1. Malaria parasites and disease -- Structure and life cycle / H. Fujioka -- Malaria parasites and the Anopheles mosquito /G. Dimopoulos -- Malaria: pathogenicity and disease / M. English -- pt. 2. Malaria antigens -- Sporozoite antigens: biology and immunology of the circumsporozoite protein and thrombospondin-related anonymous protein / P. Sinnis -- Immune responses to liver-stage parasites: implications for vaccine development / M.R. Hollingdale -- Merozoite antigens involved in invasion / K. Berzins -- Asexual blood stages of malaria antigens: cytoadherence / D.I. Baruch -- Rosetting and autoagglutination in Plasmodium falciparum / V. Fernandez -- Sexual and sporogonic stage antigens / R.W. Sauerwein -- pt. 3. Malaria infection: immunity and regulation -- Mouse models of blood-stage malaria infections: immune responses and cytokines involved in protection and pathology / J. Langhorne -- Malaria and the immune system in humans / P. Perlmann -- Genetic regulation of malaria infection in humans / M. Troye-Blomberg -- pt. 4. Malaria vaccines -- Pre-erythrocytic malaria vaccines to prevent Plasmodium flaciparum malaria / W.R. Ballou -- Vaccines against asexual stage malaria parasites / S. Kumar -- Transmission-blocking vaccines / D.C. Kaslow -- Nucleic acid vaccines against malaria / D.L. Doolan -- Antidisease vaccines / L. Schofield -- Adjuvants and malaria vaccine development / L. Xiao -- Malaria vaccine trials / B. Greenwood.
    Also available: Print – 2002
  • 2007From: CRCnetBASE
    edited by Clare Mills, Harry Wichers and Karin Hoffmann-Sommergruber.
    pt. 1. What are food allergens and allergies? -- pt. 2. Allergens in foods - from raw to processed foods -- pt. 3. Assessing allergic risks and practical management of allergens in food.
  • 2002From: Ovid
    edited by Daniel C. Adelman, Thomas B. Casale, Jonathan Corren.
    Also available: Print – 2002
  • editors, Daniel C. Adelman, Thomas B. Casale, Jonathan Corren.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction to the immune system / Lori Broderick, Taylor A. Doherty, and David Broide -- Immediate hypersensitivity : approach to diagnosis / Sarbjit S. Saini and Nkiruka Erekosima -- Aeroallergens and environmental factors / William Neaville, Robert Ausdenmoore, and Robert K. Bush -- Rhinitis / Candace Bouler Anz and Mark S. Dykewicz -- Sinusitis, nasal polyps, and otitis media / Ricardo A. Tan and Jonathan Corren -- Immunotherapy for inhalant allergens / Harold S. Nelson -- Allergic and immunologic disorders of the eye / Leonard Bielory -- Asthma diagnosis / Stephen C. Lazarus -- Asthma treatment / Joel M. Hartman ... [et al.] -- Immunologic diseases of the lung / Shefalee Amin, Michelle Zeidler, and Eric Kleerup -- Atopic dermatitis and contact dermatitis / Mark Boguniewicz, Marcella Aquino, and Luz Fonacier -- Urticaria and angioedema / Jeffrey R. Stokes and Mark H. Moss -- Anaphylaxis / Phil Lieberman and Debendra Pattanaik -- Insect allergy / David B. K. Golden -- Drug allergy / David A. Khan -- Allergic and non-allergic reactions to food / Stephen R. Boden and A. Wesley Burks -- Eosinophilic gastrointestinal disorders / Terri F. Brown-Whitehorn ... [et al.] -- Primary immunodeficiency diseases / Shradha Agarwal and Charlotte Cunningham-Rundles -- Approach to the patient with recurrent infections / Zuhair K. Ballas -- Diagnostic immunology / Thomas A. Fleisher, Joao Bosco Oliveira, and Jack J. H. Bleesing -- Adverse responses to vaccines / John M. Kelso -- Complementary medicine in allergy and immunology / Timothy Ryan Mainardi and Leonard Bielory -- Building related illness / Jessica Savage and Robert A. Wood.
  • 2016From: Am Soc Microbiol
    edited by Barbara Detrick, John L. Schmitz, Robert G. Hamilton.
    Features detailed descriptions of general and specific methodologies; special focus on the interpretation of laboratory findings. Covers the immunology of infectious diseases, including specific pathogens, and the full range of autoimmune and immunodeficiency diseases, cancer, and transplantation.
  • 2013From: Cambridge
    Joseph H. Antin, Harvard Medical School and Dana-Farber Brigham and Women's Cancer Center, Boston, MA, Deborah Yolin Raley, Dana-Farber Brigham and Women's Cancer Center, Boston, MA.
    1. Rationale for transplantation -- 2. Types of transplantation -- 3. Human leukocyte antigen matching in allogeneic transplantation -- 4. Stem cell source -- 5. Pre-transplant evaluation and counseling of patient and donor -- 6. Conditioning regimens -- 7. Stem cell infusion -- 8. ABO compatibility -- 9. Engraftment -- 10. Preventative care -- 11. Transplant-related complications -- 12. Overview of acute and chronic graft-versus-host disease -- 13. Acute graft-versus-host disease and staging -- 14. Graft-versus-host prophylactic regimens -- 15. Treatment guidelines for acute graft-versus-host disease -- 16. Chronic graft-versus-host disease -- 17. Engraftment syndrome -- 18. Infectious disease -- 19. Graft rejection and failure -- 20. Gastrointestinal complications -- 21. Oral health in stem cell transplantation -- 22. Pulmonary complications -- 23. Veno-occlusive disease -- 24. Special transfusion-related situations -- 25. Cardiovascular complications -- 26. Neurologic complications -- 27. Cystitis -- 28. Donor lymphocyte infusion -- 29. Transplantation: regulation and accreditation -- Index.
  • 2006From: Springer
    S.A. Plotkin (ed).
    Mass Vaccination: When and Why / D. L. Heymann and R. B. Aylward -- Mass Vaccination and Surveillance/Containment in the Eradication of Smallpox / J. M. Lane -- Mass Immunization Programs: Principles and Standards / J. D. Grabenstein and R. L. Nevin -- Immunization Campaigns in the UK / K. Noakes and D. Salisbury -- Diphtheria / C. R. Vitek -- Universal Mass Vaccination against Hepatitis A / F. E. André -- Mass Vaccination against Hepatitis B: the French Example / F. Denis and D. Levy-Bruhl -- Mass Vaccination for Annual and Pandemic Influenza / B. Schwartz and P. Wortley -- Is Global Measles Eradication Feasible? / C. A. de Quadros -- Measles Aerosol Vaccination / J. L. Valdespino-Gómez, M de Lourdes Garcia-Garcia, J. Fernandez-de-Castro, A. M. Henao-Restrepo, J. Bennett, and J. Sepulveda-Amor -- Mass Vaccination Campaigns for Polio Eradication: an Essential Strategy for Success / R. W. Sutter and C. Maher -- Rubella Mass Campaigns / S. Reef -- Mass Vaccination to Control Epidemic and Endemic Typhoid Fever / M. M. Levine -- Mass Vaccination: Solutions in the Skin / G. M. Glenn and R. T. Kenney.
    Also available: Print – 2006
  • 2011From: Springer
    Domenico Ribatti, Enrico Crivellato.
    Mast cells are versatile, tissue-homing secretory cells, which were first described by Paul Ehrlich in 1878. Mast cells have long been implicated in the pathogenesis of allergic reactions and certain protective responses to parasites. Their functional role, however, has been discovered to be increasingly complex and multifarious. Mast cells have been implicated in various cell-mediated immune reactions, being found in tissues from multiple disease sites, and as a component of the host reaction to bacteria, parasite, and even virus infections. They have also been shown to participate to angiogenic and tissue repair processes after injury. The importance of a possible functional link between chronic inflammation and cancer has long been recognized. As most tumours contain inflammatory cell infiltrates, which often include plentiful mast cells, the question as to the possible contribution of mast cells to tumour development has progressively been emerged. In this book, the general biology of these cells, their development, anatomical distribution and phenotype as well as their secretory products will first be discussed. The biology of tumour cells, their structural and molecular characteristics, the specificity of the tumour microenvironment and the development of a vascular network in the tumour context will be analyzed. The involvement of mast cells in tumour biology and tumour fate will then be considered, with particular emphasis on the capacity of these cells to stimulate tumour growth by promoting angiogenesis and lymphangiogenesis. The last chapter suggest that mast cells may serve as a novel therapeutic target for cancer treatment.
  • 2005From: Karger
    volume editors: Hirohisa Saito, Yoshimichi Okayama.
    Also available: Print – 2005
  • 2011From: Springer
    Carmen Molina-París, Grant Lythe, editors.
    Preface -- Thymocyte development -- A review of mathematical models for T cell receptor triggering and antigen discrimination -- Dynamic tuning of T cell receptor specificity by co-receptors and costimulation -- T cell activation and function: role of signal strength -- The cyton model for lymphocyte proliferation and differentiation -- Modeling itravital two-photon data of lymphocyte migration and interaction -- Modeling lymphocyte dynamics in vivo -- Continuous-time birth and death processes: diversity maintenance of naïve T cells in the periphery -- Multivariate competition processes: a model for two competing T cell clonotypes -- Stochastic modeling of T Cell homeostasis for two competing clonotypes via the master equation -- Dendritic cell migration in the intestinal tract -- Reassessing germinal center reaction concepts -- B cell strategies of Ag recognition in a stratified immune system -- Dynamics of Peripheral regulatory and effector T cells competing for antigen presenting cells -- Mathematical models of the role of IL-2 in the interactions between helper and regulstory CD4+ T cells -- A Physicist{u2019}s approach to immunology -- Timescales of the adaptive immune response -- Using mathematical models to explore the role of cytoxic T lymphocytes in HIV infection -- Viral immunity and persistence -- Index.
  • 2009From: Springer
    Diane E. Griffin, Michael B.A. Oldstone, editors.
    Making it to the synapse : measles virus spread in and among neurons / V.A. Young and G.F. Rall -- Modeling subacute sclerosing panencephalitis in a transgenic mouse system : uncoding pathogenesis of disease and illuminating components of immune control / M.B.A. Oldstone -- Measles studies in the macaque model / R.L. de Swart -- Ferrets as a model for morbillivirus pathogenesis, complications, and vaccines / P. Pillet, N. Svitek and V. von Messling -- Current animal models : cotton rat animal model / S. Niewiesk -- Current animal models : transgenic animal models for the study of measles pathogenesis / C.I. Sellin and B. Horvat -- Molecular epidemiology of measles virus / P.A. Rota, D.A. Featherstone, and W.J. Bellini -- Human immunology of measles virus infections / D. Naniche -- Measles control and the prospect of eradication / W.J. Moss -- Measles : old vaccines, new vaccines / D.E. Griffin and C.-H. Pan -- Measles virus for cancer therapy / S.J. Russell and K.W. Peng -- Measles virus-induced immunosuppression / S. Schneider-Schaulies and J. Schneider-Schaulies -- Hostile communication of measles virus with host innate immunity and dendritic cells / B. Hahm.
    Also available: Print – 2009
  • 2005From: Karger
    volume editors: Dieter Kabelitz, Jens-Michael Schröder.
    Also available: Print – 2005
  • 2005From: Springer
    edited by Sudhir Gupta, William E. Paul and Ralph Steinman.
    Also available: Print – 2005
  • 2007From: Springer
    edited by Sudhir Gupta, Rafi Ahmed and Alan Sher.
    Also available: Print – 2007
  • Peter S. Choi.
    Cancers arise through the acquisition of genetic and epigenetic changes which result in the activation of growth-promoting oncogenes and the inactivation of growth-inhibitory tumor suppressor genes. Despite the accumulation of many diverse mutations, some tumors exhibit sensitivity to the targeted inhibition of single gene products, in a phenomenon known as oncogene addiction. In the Emu-tTA/tetO-MYC transgenic mouse model, overexpression of MYC results in the development of aggressive T-cell lymphoma, and subsequent inactivation of MYC results in rapid tumor regression occurring primarily via cell cycle arrest, senescence, and apoptosis. This thesis presents work investigating various aspects of oncogene addiction in MYC-induced lymphomas. We have discovered that tumor recurrence in MYC-induced lymphomas following initial MYC inactivation occurs mainly through the persistence and expansion of cells that fail to suppress MYC expression. This demonstrates that addiction to some oncogenes may be inescapable and that resistance to MYC therapy would likely occur through the restoration of MYC function. We have also discovered that activation of the Wnt/beta-catenin pathway is a common secondary event in MYC-induced lymphomagenesis. Beta-catenin was found to be frequently stabilized due to mutations that prevent its phosphorylation and subsequent degradation, including a novel splice acceptor site mutation. Inhibition of beta-catenin resulted in robust apoptosis, indicating that MYC-induced lymphomas can exhibit addiction to multiple different oncogenes.
  • 2001From: CRCnetBASE
    edited by Gabriel Virella.
    Also available: Print – 2001
  • 2014From: Springer
    Yann Meunier.
    This book outlines risk assessments for 28 diseases and medical conditions including the following aspects: genetics, biochemistry, serology, past medical history, family history, co-morbidities, age, gender, ethnicity, nutrition and lifestyle. Recommendations are made for how to avoid, eliminate or mitigate risks. Preventing measures concerning chemical compound intake, lifestyle and nutrition are proposed. The unique content and approach of the book to chronic disease management make it a state-of-the-art reference work, addressing a missing component of medical care and reflecting the cutting edge of preventive medicine.
  • 2012From: CRCnetBASE
    edited by Ronald Ross Watson.
    "This new edition presents information on how melatonin is synthesized and produced in the body as well as how this hormone affects several diseases. The book heavily focuses on prevention as well as treatment of various human disease states including behavior disorders, mental disorders, breast cancer, bone health, and gastrointestinal diseases. It covers the role of melatonin in the prevention of oxidative stress, mutagenesis, sun damage, ocular health, gut motility, and detoxification. It also presents mechanisms of melatonin action in humans including cell modulation, signaling mechanisms, protective effects, and melatonin receptors as well as its role as an antioxidant"--Provided by publisher.
  • 2010From: Springer
    edited by Maurizio Zanetti, Stephen P. Schoenberger.
    Memory TH1/TH2 cell generation controlled by Schnurri-2 / Toshinori Nakayama and Motoko Y. Kimura -- Transcriptional regulation during CD8 T-cell immune responses / Ivana Munitic ... [et al.] -- The role of interleukin-2 in memory CD8 cell differentiation / Onur Boyman, Jae-Ho Cho and Jonathan Sprent -- The role of inflammation in the generation and maintenance of memory T cells / Noah S. Butler and John T. Harty -- The role of OX40 (CD134) in T-cell memory generation / Andrew D. Weinberg -- The role of precursor frequency in the differentiation of memory T cells : memory by numbers / Amanda L. Marzo, Ryan T. Sowell and Bernadette Scott -- CD8 T-cell memory differentiation during acute and chronic viral infections / Vandana Kalia, Surojit Sarkar and Rafi Ahmed -- Longevity of T-cell memory following acute viral infection / Joshua M. Walker and Mark K. Slifka -- Principles of memory CD8 T-cells generation in relation to protective immunity / Maurizio Zanetti, Paola Castiglioni and Elizabeth Ingulli -- Memory T cells in rhesus macaques / Monica Vaccari and Genoveffa Franchini -- Memory T-cell subsets in parasitic infections / Sara Colpitts and Phillip Scott -- Antigen specific memory T cells and their putative need for the generation of sustained anti-tumor responses / Kory L. Alderson and William J. Murphy -- Memory T-cell responses and survival in human cancer : remember to stay alive / Matthieu Camus and Jérôme Galon -- Analysis of vaccine-induced T cells in humans with cancer / Stefanie L. Slezak ... [et al.] -- Memory T-cell homeostasis and senescence during aging / Sian M. Henson and Arne N. Akbar.
    Also available: Print – 2010
  • 2013From: Springer
    Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
    Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • Michael John Strohman.
    B cells internalize antigen bound to membrane immunoglobulin and load antigen-derived peptides onto MHC class II proteins. How these pathways intersect is not well understood. We found that HLA-DM, a catalyst for peptide loading onto MHC class II, regulates immunoglobulin levels in human B cells and co-precipitates with immunoglobulin. In intact cells, HLA-DM and immunoglobulin are found in close proximity, and these complexes are in post-Golgi compartments. In vitro, in the endosomal pH range, the luminal domain of soluble HLA-DM (sDM) directly and specifically interacts with the immunoglobulin Fab domain, and sDM increases the amount of antigen released from immune complexes. These observations support a model in which HLA-DM facilitates the hand-off of antigen from immunoglobulin to MHC class II.
  • 2008From: Springer
    Andreas Bosio, Bernhard Gerstmayer, editors.
    Also available: Print – 2008
  • Miling Yan.
    The establishment and wide acceptance of an abundant and diverse human-associated microbial community has been one of the most important shifts in the field of microbiology in the past decade. From a bacterial perspective, the body is a vast landscape whose shifting geography and fluctuating environmental conditions provide a range of distinct residential possibilities. Some habitats, such as the intestinal tract and the oral cavity, have been characterized more extensively than others; within these environs, an understanding of the interplay between microbial ecology and health and disease has begun to emerge. The nasal cavity, a crucial component of both the respiratory system and innate immune system, has yet to benefit from an exploration of similar depth. Recent examination of the nasal microbial habitat has almost exclusively focused on the anterior nares without examining deeper sites within the cavity which are actively involved in nasal mucociliary clearance and exposed to the efflux of various sinuses. The aim of this work was to explore this biogeography by characterizing the microbial communities in a range of spatial sites along the nasal passageway. Additionally, the nasal cavity has long been a source of pathogens, most notably Staphylococcus aureus. Carriage of S. aureus has been demonstrated to be a significant risk factor for acquisition of antibiotic resistant strains of S. aureus and hospital-acquired infections. The second aim of this project was to understand whether underlying community features may be present that were characteristic of S. aureus carriage. 13 healthy subjects (6 persistent and 7 non-persistent carriers) were sampled weekly at 3 different sites (anterior nares, middle meatus, and sphenoethmoidal recess) within the nasal cavity over a 4-week period. The data shows that biogeographical differences were based less upon spatial factors and more on epithelium type. The data also showed that the S. aureus carriage type of the individual contributed the greatest amount of non-S. aureus variation within the communities. Finally, a carriage-classifying model was generated from the data and examined for important predictive features, revealing a potential intra-genus, interspecific competitive interaction in Corynebacterium with implications on S. aureus carriage. These results highlight the complexity present in human microbial communities even within highly spatially constrained microenvironments.
  • 2009From: Karger
    editors, Per Brandtzaeg, Erika Isolauri, Susan L. Prescott.
    A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- "ABC" of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. ... [et al.] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. ... [et al.] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. ... [et al.] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A.
  • Steven Schaffert.
    Much has been learned about the molecular and cellular components critical for the control of immune responses and tolerance. It remains a challenge, however, to control the immune response and tolerance at the system level without causing significant toxicity to normal tissues. Recent studies suggest that microRNAs (miRNAs), an abundant class of ~22 nucleotides regulatory RNAs, play important roles in immune cells. In this thesis, I examined the function of miR-181 genes in regulating T cell selection, development, and immune tolerance. We show that genetic ablation of mir-181a-1/b-1 ---- a T cell sensitivity tuner ---- in double-positive (DP) thymocytes dampens TCR and Erk signaling and affects positive selection. Moreover, dampening TCR signaling as the result of mir-181a-1/b-1 deletion potentiates the reactivity of self-specific T cells without significantly affecting the pool sizes of naive T cells recognizing specific self-antigens. Finally, loss of mir-181a-1/b-1 in peripheral T cells reduces their basal TCR signaling and their ability to migrate from lymph nodes to the pathogenic sites during autoimmune perturbations. Interestingly, loss of mir-181a-1/b-1 results in quantitative defects in various T and B lymphocyte populations, but does not cause major structural damage to the immune system or spontaneous autoimmunity. Our findings illustrate that mir-181a-1/b-1 controls tolerance through opposing activities in selection and peripheral T cell function. Thus, despite the subtle effects of miRNAs on gene expression, miRNAs have the potential to influence the outcomes of normal and pathogenic immune responses by controlling the quantitative and dynamic aspects of immune responses.
  • 2015From: Springer
    Catherine M. Greene, editor.
    The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohnĺls disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
    Also available: Print – 2015
  • 2010From: Springer Protocols
    edited by Silvia Monticelli.
    A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation -- Normalization of microRNA quantitative RT-PCR data in reduced scale experimental designs -- MicroRNA detection in bone marrow cells by LNA-FISH -- Measuring microRNA expression in size-limited facs-sorted and microdissected samples -- MicroRNA cloning from cells of the immune system -- High-throughput profiling in the hematopoietic system -- Construction of small RNA cDNA libraries for deep sequencing -- MicroRNA-profiling in formalin-fixed paraffin-embedded specimens -- Expression of miRNAs in lymphocytes : A review -- Mouse models for miRNA expression: The ROSA26 locus -- Regulation of monocytopoiesis by microRNAs -- MicroRNA activity in B lymphocytes -- Isolation and characterization of microRNAs of human mature erythrocytes -- Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors -- Monitoring microRNA activity and validating microRNA targets by reporter-based approaches -- Lentivirus-mediated antagomir expression -- Solution structure of miRNA:mRNA complex -- MiRNA editing -- Computational prediction of microRNA targets -- Large-scale integration of microRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems -- Identification and validation of the cellular targets of virus-encoded microRNAs.
  • [edited by] N. Franklin Adkinson, Jr. ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014From: ClinicalKey
    Adkinson, N. Franklin; Middleton, Elliott.
  • 2017From: ClinicalKey
    Robyn E. O'Hehir, Stephen T. Holgate, Aziz Sheikh.
    Introduction to mechanisms of allergic diseases -- The origins of allergic disease -- Epidemiology of allergic diseases -- Indoor and outdoor allergens and pollutants -- Principles of allergy diagnosis -- Allergen-specific immunotherapy -- Asthma -- Allergic rhinitis and conjunctivitis -- Drug allergy -- Urticaria and angioedema without wheals -- Atopic dermatitis and allergic contact dermatitis -- Food allergy and gastrointestinal syndromes -- Anaphylaxis -- Occupational allergy -- Insect allergy.
  • Richard Bucala, Jürgen Bernhagen, editors.
    MIF and CD74-dependent Mechanisms -- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies -- MIF-dependent Regulation of Monocyte/Macrophage Polarization -- Advances in understanding the role of MIF in the pathogenesis of autoimmune diseases -- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis -- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis -- MIF and Pulmonary Disease -- MIF Mediates Pelvic Inflammation and Pain -- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury -- The MIF-CD74 Inflammatory Axis in Alphaviral Infection -- MIF in Eosinophilic Inflammation -- The Role of MIF in Parasitic Infections -- Parasite MIF Orthologs.
  • Lena Pernas.
    Protozoan and prokaryotic pathogens are able to recruit mitochondria to the vacuoles in which they grow (Friis, 1972; Horwitz, 1983), in mammalian and protozoan cells. The functional significance of the recruitment and association of this phenomenon in Toxoplasma-infected cells has been a subject of speculation since it was first described in the early 1970s (Jones et al., 1972). Previous work has proposed Toxoplasma gondii rhoptry protein 2 (Sinai and Joiner, 2001) as the physical link that tethers host mitochondria to the parasitophorous vacuole and conventional wisdom since has suggested that mitochondrial recruitment served a nutritional function supplementary to the parasite. A recent analysis of the ROP2 structure raised questions about this model ((Labesse et al., 2009; Reese and Boothroyd, 2009). Chapter II describes the effect of deleting ROP2 on mitochondrial association while Chapter III describes the identification of a novel mediator of mitochondrial association, Mitochondrial association factor I (MAF1) and experiments that attempt to answer the role of this remarkable phenomenon in the host-pathogen interaction. Chapter IV describes a project undertaken to determine the impact of Toxoplasma gondii infection in humans acutely and chronically infected in different geographical regions. Chapter V concludes with a discussion of future directions for further characterization of host mitochondrial association in the host response to microbial infection.
  • 2017From: Springer
    Lorenzo Drago, editor.
    The concept of biofilm-related implant malfunction and "low-grade infection" -- Mechanisms of bacterial colonization of implants and host response -- Animal models of implant-related low-grade infections, a twenty-year review -- Microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma -- Antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Prosthetic joint infections and cost analysis? -- Algorithm to diagnose delayed and late PJI: role of joint aspiration -- Erratum: microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- Erratum: antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Index.
  • Erica Machlin Cox.
    Hepatitis C virus (HCV) is a global health problem, infecting approximately 2% of the world's population. The virus is hepatotropic, replicating in liver cells, and its only known hosts are humans and chimpanzees. HCV is an unusual virus in that it requires the liver-specific host microRNA (miRNA) miR-122 for HCV RNA accumulation. Though the precise mechanism by which miR-122 upregulates HCV RNA is still under investigation, it is known that miR-122 must bind to two adjacent sites in the 5' end of the HCV genome. In this dissertation, a stepwise mutational analysis of the entire sequence of miR-122 was performed to identify residues important for HCV RNA accumulation. All mutant miRNAs were tested in canonical miRNA reporter assays and in HCV RNA accumulation assays. The identities of two nucleotides within miR-122, at positions 15 and 16, were shown to be dispensable for canonical miRNA and siRNA activity but required for HCV RNA accumulation. Compensatory mutations in the HCV genome upstream of the original binding sites uncovered supplementary binding sites for nucleotides 15 and 16 of miR-122. This analysis led to a new model for miR-122-HCV RNA interactions. To further define the requirements of HCV for miR-122, we investigated whether the predecessor of mature miR-122, a long hairpin precursor designated pre-miR-122, was also able to mediate HCV RNA accumulation. The function of pre-miR-122 was tested in miRNA, siRNA, and HCV RNA accumulation assays. Inhibition of pre-miR-122 processing was achieved by substituting deoxyribonucleotides into the loop of pre-miR-122 to prevent Dicer-mediated cleavage. Full-length pre-miR-122 was demonstrated to be functional in miRNA and siRNA assays and to be sufficient for HCV RNA accumulation. Pre-miR-122 also required traditional components of the RNA-induced silencing complex (RISC) for activity. Taken together, this research has uncovered novel requirements of miR-122 for HCV RNA accumulation. Components shown to be dispensable for canonical miRNA interactions were necessary for this unusual microRNA-target RNA interaction. Uncovering hepatitis C virus's stringent requirements for the mature and precursor forms of miR-122 will pave the way for new antiviral therapies targeting a host factor.
  • 2005From: Springer
    H. Singh and R. Grosschedl (ed.).
    Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation / K.L. Medina, H. Singh -- Helix-loop-helix proteins in lymphocyte lineage determination / B.L. Kee -- Ikaros-family proteins : in search of molecular functions during lymphocyte development / B.S. Cobb, S.T. Smale -- Biochemistry of V(D)J recombination / D.G. Schatz, E. Spanopoulou -- The pre-B cell receptor in B cell development : recent advances, persistent questions and conserved mechanisms / M.R. Clark ... [et al.] -- Transcriptional control of B cell activation / L.M. Corcoran -- Expression of MHC II genes / G. Drozina ... [et al.] -- Class switch recombination : an emerging mechanism / A.L. Kenter -- Blimp-1 ; Immunoglobulin secretion and the switch to plasma cells / R. Schiammas, M.M. Davis -- Wnt signaling in lymphopoiesis / A. Timm, R. Grosschedl.
    Also available: Print – 2005
  • 2014From: Springer
    Falk Nimmerjahn, editor.
    This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • 2005From: Springer
    edited by Moncef Zouali.
    Also available: Print – 2005
  • 2011From: Springer
    Albert M. Wu, editor.
    Part 1. Introduction to Glyco-Experiences -- Serendipity in Scientific Discoveries: Some Examples in Glycosciences / Yuan-Chuan Lee -- My 30-Year Devotion to the N-Linked Oligosaccharide Structures / Noriko Takahashi -- Part 2. Blood Group ABH/Le-related Antigens -- Human Blood Group ABH/Ii, Lea,b,x,y, and Sialyl Lea,x Glycotopes; Internal Structures; and Immunochemical Roles of Human Ovarian Cyst Glycoproteins / Albert M. Wu -- Lewis Glyco-Epitopes: Structure, Biosynthesis, and Functions / Hui-Li Chen -- A Unique Endo-β-Galactosidase that Cleaves Both Blood Group A and B Glycotopes / Su-Chen Li, Kimberly M. Anderson and Yu-Teh Li -- Part 3. Lectins -- Recognition Roles of Mammalian Structural Units and Polyvalency in Lectin-Glycan Interactions / Albert M. Wu, Jia-Haw Liu, Tanuja Singh and Zhangung Yang -- Adhesion/Growth-Regulatory Galectins: Insights into Their Ligand Selectivity Using Natural Glycoproteins and Glycotopes / Albert M. Wu, Tanuja Singh, Jia-Hau Liu, Sabine André and Martin Lensch, et al. -- Glycotope Structures and Intramolecular Affinity Factors of Plant Lectins for Tn/T Antigens / Pierre Rougé, Willy J. Peumans, Els J. M. Van Damme, Annick Barre and Tanuja Singh, et al. -- The Five Bacterial Lectins (PA-IL, PA-IIL, RSL, RS-IIL, and CV-IIL): Interactions with Diverse Animal Cells and Glycoproteins / Nechama Gilboa-Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Batya Lerrer and Anne Imberty, et al. -- On the Differential Sialic Acid Specificity of Lectins from Different Parts of Saraca indica / Bishnu P. Chatterjee and Mainak Majumder -- Regulation of Lectin Production by the Human Pathogens Pseudomonas aeruginosa and Chromobacterium violaceum: Effects of Choline, Trehalose, and Ethanol / Nachman C. Garber, Keren D. Zinger-Yosovich, Dvora Sudakevitz, Itschak Axelrad and Nechama Gilboa-Garber -- Non-carbohydrate-Mediated Interaction of Lectins with Plant Proteins / Jared Q. Gerlach, Michelle Kilcoyne, Seron Eaton, Veer Bhavanandan and Lokesh Joshi -- Novel Concepts About the Role of Lectins in the Plant Cell / Els J. M. Van Dammes, Elke Fouquaert, Nausicaä Lannoo, Gianni Vandenborre and Dieter Schouppe, et al. -- Part 4. Structures and Functions of Glycolipids -- Role of Gangliosides and Plasma Membrane-Associated Sialidase in the Process of Cell Membrane Organization / Sandro Sonnino, Vanna Chigorno, Massimo Aureli, Anie Priscilla Masilamani and Manuela Valsecchi, et al. -- 9-O-Acetyl GD3 in Lymphoid and Erythroid Cells / Kankana Mukherjee, Suchandra Chowdhury, Susmita Mondal, Chandan Mandal and Sarmila Chandra, et al. -- GM3 Upregulation of Matrix Metalloproteinase-9 Possibly Through PI3K, AKT, RICTOR, RHOGDI-2, and TNF-A Pathways in Mouse Melanoma B16 Cells / Pu Wang, Xiaodong Wang, Peixing Wu, Jinghai Zhang and Toshinori Sato, et al. -- Pathological Roles of Ganglioside Mimicry in Guillain-Barré Syndrome and Related Neuropathies / Robert K. Yu, Toshio Ariga, Seigo Usuki and Ken-ichi Kaida -- Structure and Function of Glycolipids in Thermophilic Bacteria / Feng-Ling Yang, Yu-Liang Yang and Shih-Hsiung Wu -- Lipooligosaccharides of Neisseria Species: Similarity Between N. polysaccharea and N. meningitidis LOSs / Chao-Ming Tsai -- Part 5. Structures and Functions of Complex Carbohydrates -- Roles for N- and O-Glycans in Early Mouse Development / Suzannah A. Williams and Pamela Stanley -- Glycobiology in the Field of Gerontology (Glycogerontology) / Akira Kobata -- Galectins in Regulation of Apoptosis / Fu-Tong Liu, Ri-Yao Yang, Jun Saegusa, Huan-Yuan Chen and Daniel K. Hsu -- Avian and Human Influenza Virus Receptors and Their Distribution / Yasuo Suzuki -- Importance of a Factor VIIIc-Like Glycoprotein Expressed in Capillary Endothelial Cells (eFactor VIIIc) in Angiogenesis / Dipak K. Banerjee, Caroline M. Oliveira, José J. Tavárez, Viswa N. Katiyar and Subiman Saha, et al. -- Mucin O-Glycan Branching Enzymes: Structure, Function, and Gene Regulation / Pi-Wan Cheng and Prakash Radhakrishnan -- Studying Carbohydrate Self-Recognition in Marine Sponges Using Synthetic Aggregation Factor Epitopes / Johannis P. Kamerling and Adriana Carvalho de Souza -- Docking of Chitin Oligomers and Nod Factors on Lectin Domains of the LysM-RLK Receptors in the Medicago-Rhizobium Symbiosis / Pierre Rougé, Wim Nerinckx, Clare Gough, Jean-Jacques Bono and Annick Barre -- Part 6. Glycoimmunology -- O-Acetylated Sialic Acids and Their Role in Immune Defense / Roland Schauer, G. Vinayaga Srinivasan, Dirk Wipfler, Bernhard Kniep and Reinhard Schwartz-Albiez -- Sialylated and Sulfated Carbohydrate Ligands for Selectins and Siglecs: Involvement in Traffic and Homing of Human Memory T and B Lymphocytes / Reiji Kannagi, Katsuyuki Ohmori, Guo-Yun Chen, Keiko Miyazaki and Mineko Izawa, et al. -- Diversity of Natural Anti-α-Galactosyl Antibodies in Human Serum / Elwira Lisowska and Maria Duk -- Significance of Serum Glycoprotein Profiles in Spontaneous Tolerance After Liver Allograft Transplantation / Pei-Weng Wang and Tai-Long Pan -- Part 7. Glycobiology of Cancer -- Hematogenous Metastasis: Roles of CD44v and Alternative Sialofucosylated Selectin Ligands / Konstantinos Konstantopoulos and Susan N. Thomas -- Regulation of Glycosyltransferase Genes in Apoptotic Breast Cancer Cells Induced by l-PPMP and Cisplatin / Rui Ma, Elizabeth A. Hopp, N. Matthew Decker, Audrey Loucks and James R. Johnson, et al. -- Aberrant Glycosphingolipid Expression and Membrane Organization in Tumor Cells: Consequences on Tumor-Host Interactions / Alessandro Prinetti, Simona Prioni, Nicoletta Loberto, Massimo Aureli and Valentina Nocco, et al. -- Human KDN (Deaminated Neuraminic Acid) and Its Elevated Expression in Cancer Cells: Mechanism and Significance / Sadako Inoue, Ken Kitajima, Chihiro Sato and Shinji Go -- Polysialic Acid Bioengineering of Cancer and Neuronal Cells by N-Acyl Sialic Acid Precursor Treatment / Robert A. Pon, Wei Zou and Harold J. Jennings -- Part 8. Glyco Applications -- Synthesis of Hemagglutinin-Binding Trisaccharides / Cheng-Chung Wang, Suvarn S. Kulkarni, Medel Manuel L. Zulueta and Shang-Cheng Hung -- Fabrication and Applications of Glyconanomaterials / Po-Chiao Lin, Avijit Kumar Adak and Chun-Cheng Lin -- Glycan Arrays to Decipher the Specificity of Plant Lectins / Els J. M. Van Damme, David F. Smith, Richard Cummings and Willy J. Peumans -- Targeting C-Type Lectin for the Treatment of Flavivirus Infections / Szu-Ting Chen, Yi-Ling Lin, Ming-Ting Huang, Ming-Fang Wu and Shie-Liang Hsieh.
    Also available: Print – 2011
  • 2014From: Springer
    edited by Hubert Hilbi.
    Legionnaires' disease, a potentially fatal type of pneumonia primarily affecting elderly and immuno-compromised persons, is caused by the ubiquitous environmental bacterium Legionella pneumophila. This book offers authoritative reviews of different facets of its virulence, focusing on comparative phagocyte infection, virulence gene regulation, biochemical functions of effector proteins and cellular pathogen-host interactions, as well as host responses and immunity to L. pneumophila. Taken together, the contributions in this compilation provide a state-of-the-art overview of current insights into the molecular pathogenesis of the opportunistic and potentially fatal pathogen L. pneumophila.
  • Amy Colleen Palin.
    Human neonates are highly susceptible to infection by intracellular pathogens compared to adults, due in large part to a reduction in CD4+ T cell-mediated T helper type 1 (Th1) immunity. We have investigated the molecular mechanisms in the neonatal naive CD4+ T cell response that contribute to this reduction in neonatal Th1 immunity, and have identified differences in gene expression, epigenetic regulation, and T cell receptor signaling between neonatal an adult naive CD4+ T cells. Significantly, neonatal naive CD4+ T cells flux calcium to a higher degree than do adult naive CD4+ T cells in response to CD3 engagement. This enhanced calcium signaling is mediated by higher levels of the microRNA miR-181a, and is not accompanied by an increase in response to CD28-mediated costimulation. In neonatal cells, an increase in calcium signaling relative to a lack of induction of the AP-1 transcription factor indicates that neonatal naive CD4+ T cells may be prone to an anergic response. Neonatal naive CD4+ T cells share an enhanced calcium response with adult CD4+ recent thymic emigrants, a less mature peripheral CD4+ T cell population. We have also confirmed decreased capacity of neonatal naive CD4+ T cells to produce the prototypic Th1 cytokine interferon-gamma (IFN-[gamma]), and have obtained evidence that epigenetic modifications mediated by de novo methyltransferase 3a (Dnmt3a) are responsible for impaired cytokine production. Comprehensive profiling of gene expression and microRNA expression have uncovered further support for our functional observations of increased calcium flux and reduced Th1 function in neonatal naive CD4+ T cells. We have found that neonatal naive CD4+ T cells have reduced Th1 function and have enhanced T cell receptor proximal signaling in the absence of an enhanced response to costimulation, constituting a unique T cell phenotype.
  • 2009From: Springer
    Chihiro Sasakawa, editor.
    Functional morphology of the gastrointestinal tract / L. Shen -- Vibrio cholerae interactions with the gastrointestinal tract: Lessons from animal studies / J.M. Ritchie and M.K. Waldor -- Interaction of Yersinia with the gut: Mechanisms of pathogenesis and immune evasion / P. Dube -- Molecular mechanisms of Salmonella virulence and host resistance / Y. Valdez, R.B.R. Ferreira and B.B. Finlay -- Virulence mechanisms and persistence strategies of the human gastric pathogen Helicobacter pylori / tW. Fischer, S. Prassl and R. Haas -- Listeria as an enteroinvasive gastrointestinal pathogen / S.B. Barbuddhe and T. Chakraborty -- Molecular mechanisms of Campylobacter infection / J.P.M. Putten ... [et al.] -- Shigella infection of intestinal epithelium and circumvention of the host innate defense system / H. Ashida ... [et al.].
    Also available: Print – 2009
  • Jonathan Wiley Jones.
    Francisella tularensis is a facultative intracellular pathogen that causes the disease tularemia. The ability of F. tularensis to escape phagosomal degradation and replicate in the macrophage cytosol is central to its pathogenesis. The macrophage responds to the presence of cytosolic F. tularensis with the production of type-I interferons (IFN) and subsequent activation of the inflammasome. We conducted a forward genetic screen of a F. novicida transposon library to identify mutants that resulted in an increased or decreased cytosolic response in macrophages. We identified 164 F. novicida mutants that lead to increased type-I IFN production and inflammasome activation in macrophages. We also identified 74 mutants that resulted in decreased type-I IFN and inflammasome responses in macrophages. Finally, we identified AIM2 as the host receptor responsible for inflammasome activation in response to cytosolic F. novicida. We showed that lysing cytosolic F. novicida leads to release of bacterial DNA that triggers type-IFN through a pathway involving the adaptor STING. STING-dependent type-I IFN production increases the expression of AIM2, which complexes with the bacterial DNA and initiates inflammasome activation. We further demonstrate that AIM2 is critical for innate immunity to F. novicida infection in vivo. Thus we identified a novel bacterial ligand and novel cytosolic sensing components that play a role in the host defense to bacterial infections.
  • 2005From: Springer
    M.B.A. Oldstone (ed.).
    Molecular mimicry, microbial infection, and autoimmune disease : evolution of the concept / M.B.A. Oldstone -- The structural interactions between T cell receptors and MHC-peptide complexes place physical limits on self-nonself discrimination / K.W. Wucherpfennig -- A virus-induced molecular mimicry model of multiple sclerosis / J.K. Olson, A.M. Ercolini, and S.D. Miller -- Suppression of autoimmunity via microbial mimics of altered peptide ligands / L. Steinman, P.J. Utz, and W.H. Robinson -- Molecular and cellular mechanisms, pathogenesis, and treatment of insulin-dependent diabetes obtained through study of a transgenic model of molecular mimicry / M.B.A. Oldstone -- Trypanosoma cruzi-induced molecular mimicry and Chagas' disease / N. Gironès, H. Cuervo, and M. Fresno -- HTLV-1 induced molecular mimicry in neurological disease / S.M. Lee ... [et al.] -- Molecular mimicry : anti-DNA antibodies bind microbial and nonnucleic acid self-antigens / J.S. Rice ... [et al.] -- Chlamydia and antigenic mimicry / K. Bachmaier and J.M. Penninger.
    Also available: Print – 2005
  • Poornima Parameswaran.
    Small RNAs that are 19-30 nucleotides in length use the genetic information encoded in their sequence to effect gene regulation in a sequence-directed manner. Infections with RNA viruses in plants, worms and flies generate short viral-derived RNAs ("vsRNAs") that map to the genome of the infecting virus. The regulated production of these vsRNAs and their engagement by the immune apparatus is essential for inhibiting viral growth, making vsRNAs important components of antiviral immunity in these organisms. RNA virus-derived vsRNA-mediated gene silencing is yet to be demonstrated in mammalian systems. We investigated diverse RNA virus-mammalian systems, and characterized changes in small RNA populations that occur during viral infection in animal cells using high-throughput sequencing. Due to the large number of samples to be analyzed, we designed DNA barcodes to 'tag' RNA samples from individual experiments, which facilitated sequencing in parallel from multiple samples. Our work demonstrated the generality of RNA virus-derived vsRNA production, and the ability of the cellular short RNA apparatus to engage these vsRNAs in worms during Flock House Virus replication, and in mammalian cells during infections with Hepatitis C, Polio, Dengue, Vesicular Stomatitis or West Nile virus. In addition to the appearance of vsRNAs during infection, we saw a number of specific changes in host-encoded small RNA (miRNA) profiles. For several infection models investigated in more detail, the RNAi and Interferon pathways modulated the abundance of vsRNAs. We found evidence for populations of vsRNAs that exist as duplexed small interfering RNAs ("siRNAs; " effectors of gene silencing) with zero to three nucleotide 3' overhangs. We also observed strand-selective loading of siRNAs onto Argonaute complexes, which are mediators of gene silencing. We quantitated the capacity of these HCVrep-derived vsRNAs to down-regulate target mRNAs in a sequence-specific manner in mammalian systems. We found that abundant HCVrep vsRNAs are not capable of mediating robust silencing (i.e. 2-fold or higher) of Luciferase reporters that have been engineered with vsRNA targets. Additionally, over-expression of siRNAs corresponding to five abundant vsRNAs failed to enhance silencing of Hepatitis C Virus mRNA. These results complement each other and suggest that in mammalian hosts, the virus may coexist with an abundant population of vsRNAs. Questions still remain as to whether robust gene silencing may be achieved by the cooperative action of abundant vsRNAs, or if abundant vsRNAs specifically inhibited from functioning in gene silencing, or alternatively, if they have novel roles in pathways distinct from gene silencing.
  • 2013From: Springer
    Matthias Giese, editor.
    This book gives a comprehensive overview to all aspects of global molecular vaccine research. It introduces concepts of vaccine immunology and molecular vaccine development for viral, bacterial, parasitic and fungal infections. Furthermore, the broad field of research and development in molecular cancer vaccines is discussed in detail. This book is a must have for scientists and clinicians interested in new developments in molecular vaccine research and application in infections and cancer.
  • 2014From: Springer
    Matthias Giese, editor.
    This title discusses all aspects of non-infectious and non-cancer -- so called NINC -- vaccines. Hypertension, diabetes and allergy vaccine development are referred to as well as the use of adjuvants and nanotechnology in vaccine development. The way of novel vaccines from bench to preclinical to clinical studies and launch to the market under EMEA (European Medicines Agency) and FDA (Food and Drug Administration) guidelines are described in-depth. Practical perspectives of patentability of vaccines are discussed. The book is therefore of interest for researchers and clinicians engaged in vaccine development and molecular vaccine application.
  • 2014From: Springer Protocols
    edited by Vincent Ossipow, Nicolas Fischer.
    Antigen production for monoclonal antibody generation / Giovanni Magistrelli and Pauline Malinge -- Method for the generation of antibodies specific for site and posttranslational modifications / Hidemasa Goto and Masaki Inagaki -- Immunization, hybridoma generation, and selection for monoclonal antibody production / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Hybridoma technology for the generation of rodent mAbs via classical fusion / Efthalia Chronopoulou [and three others] -- Generation of rabbit monoclonal antibodies / Pi-Chen Yam and Katherine L. Knight -- Screening hybridomas for cell surface antigens by high-throughput homogeneous assay and flow cytometry / Alejandro Uribe-Benninghoff [and four others] -- Screening and subcloning of high producer transfectomas using semisolid media and automated colony picker / Suba Dharshanan and Cheah Swee Hung -- Design and generation of synthetic antibody libraries for phage display / Gang Chen and Sachdev S. Sidhu -- Selection and screening using antibody phage display libraries / Patrick Koenig and Germaine Fuh -- Yeast surface display for antibody isolation : library construction, library screening, and affinity maturation / James A.Van Deventer and Karl Dane Wittrup -- Human B cell immortalization for monoclonal antibody production / Joyce Hui-Yuen, Siva Koganti, and Sumita Bhaduri-McIntosh -- Using next-generation sequencing for discovery of high- frequency monoclonal antibodies in the variable gene repertoires from immunized mice / Ulrike Haessler and Sai T. Reddy -- Cloning, reformatting, and small-scale expression of monoclonal antibody isolated from mouse, rat, or hamster hybridoma / Jeremy Loyau and François Rousseau -- Cloning of recombinant monoclonal antibodies from hybridomas in a single mammalian expression plasmid / Nicole Müller-Sienerth [and three others] -- Monoclonal antibody purification by ceramic hydroxyapatite chromatography / Larry J. Cummings, Russell G. Frost, and Mark A. Snyder -- Rapid purification of monoclonal antibodies using magnetic microspheres / Pauline Malinge and Giovanni Magistrelli -- Generation of cell lines for monoclonal antibody production / Krista Alvin and Jianxin Ye -- Expression and purification of recombinant antibody formats and antibody fusion proteins / Martin Siegemund [and four others] -- Purification of antibodies and antibody fragments using CaptureSelect [trademark] affinity resins / Pim Hermans, Hendrik Adams, and Frank Detmers -- Reformatting of scFv antibodies into the scFv-Fc format and their downstream purification / Emil Bujak [and three others] -- Antibody V and C domain sequence, structure, and interaction analysis with special reference to IMGT® / Eltaf Alamyar [and three others] -- Measuring antibody affinities as well as the active concentration of antigens present on a cell surface / Palaniswami Rathanaswami -- Determination of antibody structures / Robyn L. Stanfield -- Affinity maturation of monoclonal antibodies by multi-site- directed mutagenesis / Hyung-Yong Kim, Alexander Stojadinovic, and Mina J. Izadjoo -- Epitope mapping with membrane-bound synthetic overlapping peptides / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping by epitope excision, hydrogen/deuterium exchange, and peptide-panning techniques combined with in silico analysis/ Nicola Clementi [and five others] -- Fine epitope mapping based on phage display and extensive mutagenesis of the target antigen / Gertrudis Rojas -- Epitope mapping with random phage display library / Terumi Midoro-Horiuti and Randall M. Goldblum -- Epitope mapping of monoclonal and polyclonal antibodies using bacterial cell surface display / Anna-Luisa Volk, Francis Jingxin Hu, and Johan Rockberg -- Ion exchange-high-performance liquid chromatography (IEX-HPLC) / Marie Corbier, Delphine Schrag, and Sylvain Raimondi -- Size exclusion-high-performance liquid chromatography (SEC-HPLC) / Delphine Schrag, Marie Corbier, and Sylvain Raimondi -- N-glycosylation characterization by liquid chromatography with mass spectrometry / Song Klapoetke -- Fc engineering of antibodies and antibody derivatives by primary sequence alteration and their functional characterization / Stefanie Derer [and six others] -- Labeling and use of monoclonal antibodies in immunofluorescence : protocols for cytoskeletal and nuclear antigens / Christoph R. Bauer -- Generation and use of antibody fragments for structural studies of proteins refractory to crystallization / Stephen J. Stahl, Norman R. Watts, and Paul T. Wingfield -- Antibody array generation and use / Carl A.K. Borrebaeck and Christer Wingren.
  • 2007.From: Springer Protocols
    edited by Maher Albitar.
  • 2013From: Future Med
    editor, Fatih M. Uckun.
    Monoclonal antibodies in contemporary cancer therapy / Fatih M. Uckun -- mAbs targeting CD20 and other lymphocyte CD markers in lymphoma treatment / Letizia Polito, Rossella Mancuso, Daniele Mercatelli, Massimo Bortolotti & Andrea Bolognesi -- mAbs targeting CTLA-4 and clinical outcomes / Francesco Spagnolo, Virginia Picasso & Paola Queirolo -- mAbs targeting VEGF/VEGFR and clinical outcomes in cancer treatment / Brendan Curley, Michael Newton & Jame Abraham -- mAbs targeting RANKL in bone metastasis treatment / Bérengère Gobin, Marc Baud'Huin, Bertrand Isidor, Dominique Heymann & Marie-Françoise Heymann -- Novel mAb-based therapies for leukemia / Osmond J. D'Cruz & Fatih M. Uckun -- Index.
  • 2014From: Wellcome Trust
    edited by E.M. Jones and E.M. Tansey.
  • 2013From: Springer Protocols
    edited by Irving C. Allen.
    Transgenic Mouse Models -- Pulmonary Antigen Presenting Cells: Isolation, Purification, and Culture -- Evaluation of T Cell Function in Allergic Disease -- Evaluating B-Cells: From Bone Marrow Precursors to Antibody Producing Cells -- Protocols for Identifying, Enumerating and Assessing Mouse Eosinophils -- Evaluation of Classical, Alternative, and Regulatory Functions of Bone Marrow-Derived Macrophages -- Applications of Mouse Airway Epithelial Cell Culture for Asthma Research -- Isolation and Characterization of Mast Cells in Mouse Models of Allergic Diseases -- Purifying and Measuring Immunoglobulin E (IgE) and Anti-IgE -- Protocols for the Induction and Evaluation of Systemic Anaphylaxis in Mice -- Contact Hypersensitivity Models in Mice -- Induction of Allergic Rhinitis in Mice -- Induction of Allergic Airway Disease Using House Dust Mite Allergen -- An Inhalation Model of Allergic Fungal Asthma: Aspergillus fumigatus-Induced Inflammation and Remodeling in Allergic Airways Disease -- PAMPs and DAMPs in Allergy Exacerbation Models -- Assessment of Airway Hyperresponsiveness in Mouse Models of Allergic Lung Disease Using Detailed Measurements of Respiratory Mechanics -- Bilateral Vagotomy as a Tool for Determining Autonomic Involvement in Airway Responses in Mouse Models of Asthma -- Clara Epithelial Cell Depletion in the Lung -- A Mouse Model for Evaluating the Contribution of Fibrocytes and Myofibroblasts to Airway Remodeling in Allergic Asthma -- Assessment of Airway Hyperresponsiveness in Murine Tracheal Rings -- Use of the Cockroach Antigen Model of Acute Asthma to Determine the Immunomodulatory Role of Early Exposure to Gastrointestinal Infection -- Expression Profiling to Identify Candidate Genes Associated with Allergic Phenotypes -- Flow Cytometric Methods for the Assessment of Allergic Disease -- Generation of Bone Marrow and Fetal Liver Chimeric Mice.
  • 2013From: Springer Protocols
    edited by Irving C. Allen.
    The innate immune system represents a critical arm of the immune response by providing immediate and robust host defense; however, human studies of its function are often limited by ethical, logistical, and technical obstacles. In Mouse Models of Innate Immunity: Methods and Protocols, experts in the field explore the design and execution of experiments used to thoroughly evaluate critical elements associated with the host innate immune response. The volume opens with methods that are essential for collecting and assessing various primary cells that are highly relevant to innate immunity, and it continues with in vivo protocols commonly used to evaluate the innate immune response in the mouse, including mouse models of respiratory infection, gastrointestinal inflammation, fungal and parasitic diseases, sepsis, and HIV-1 infection. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and easy to use, Mouse Models of Innate Immunity: Methods and Protocols will serve the research community by providing expert advice and protocols that allow both experienced and novice investigators to successfully plan, implement, and assess disease processes associated with the innate immune response.
  • 2007From: Springer
    edited by Charlotte Slayton Kaetzel.
  • 2006From: Springer
    Stephen K. Tyring (ed.).
    The role of mucosal immunity in protection against viral diseases / Vandana Madkan, Karan Sra, and Stephen K. Tyring -- Anogenital mucosal immunology and virology / Anthony Simmons -- Gastrointestinal mucosal immunology / David A. Bland, Carlos A. Barrera, and Victor E. Reyes -- Virology of the gastrointestinal tract / Richard L. Ward ... [et al.] -- Oral manifestations of viral diseases / Denis P. Lynch -- Common respiratory viruses and pulmonary mucosal immunology / David B. Huang -- Ophthalmic manifestations of viral diseases / Steven Yeh and Mitchell P. Weikert.
  • 2013From: Springer
    Alice Prince, editor.
    In contrast to the substantial literature that focuses upon innate immune signaling in the gut, there is remarkably less known about the response of the airway to bacterial pathogens. The purpose of this book will be to review the current status of theunderstanding of the pathogenesis of acute bacterial pneumonia, slanted toward the mucosal immunology of these infections. It will describe, in general, the signaling cascades that control the proinflammatory response to bacterial infection in the lung. How innate immune signaling is orchestrated in response to specific common airway pathogens is addressed, targeting Staphylococus aureus (including MRSA), Streptococcus pneumoniae and Klebsiella pneumoniae. By describing the general immunological responses to conserved bacterial components and then detailing how specific organisms cause infection, this book provides a targeted but comprehensive review of this important topic.
  • 2005From: ScienceDirect
    edited by Jiri Mestecky, Michael E. Lamm, Jerry R. McGhee ... [et al.].
    Also available: Print – v. 1-2, 2005.
  • 2012From: Springer
    Pamela A. Kozlowski, editor.
    Most human pathogens utilize mucosal surfaces to access the host. This volume is focused on the development of vaccines which generate immune effectors capable of blocking mucosal entry or peripheral pathogen spread. A critical first step in the design of mucosal vaccines is the selection of administration route. Not all mucosal immunization routes are created equally when it comes to eliciting immune responses in multiple body compartments. This subject and situations when a mucosal route may not be required for vaccine delivery are reviewed here with an emphasis on the sublingual immunization route, which may offer a safer alternative to the nasal route for induction of broadly disseminated immune responses. External host defenses that inhibit entry of microorganisms at mucosal surfaces also pose obstacles to the efficient internalization of mucosally-applied vaccines. Transcutaneous immunization with appropriate adjuvants and permeation enhancers can induce mucosal immune responses and may be advantageous for bypassing these luminal barriers. Other chapters describe strategies for enhancing uptake of mucosal vaccines, for instance through targeted delivery to antigen-sampling M cells, construction of virus-like particles which mimic natural pathogens, addition of mucoadhesives or formulation as nanoparticles. Topics include edible vaccines as well as plant-based production of subunit or particulate vaccines that could be administered by any route. Dry powder vaccines that could be insufflated or directly applied to mucosal surfaces may be particularly ideal for mass vaccination in developing countries. The manufacture, stability and efficacy of powder formulations is comprehensively reviewed. We conclude with chapters on two of the greatest challenges facing mucosal vaccine development: human immunodeficiency virus and bioterrorist agents. This monograph highlights progress and information that should prove invaluable for the development of contemporary vaccines that prevent infection by these and other mucosal pathogens.
  • 2012From: Springer
    [edited by] Zhong-Shan Gao, Hua-Hao Shen, Min Zheng, Lynn J. Frewer, Luud J.W.J. Gilissen.
    Part I. General Allergy. Prevalence of Allergic Diseases in China / Huan Qian, Min Zheng -- Mechanism of Type I Hypersensitivity / Cheng Zhou -- Multidisciplinary Approaches to Allergy Prevention / Luud J.W.J. Gilissen, Zhong-Shan Gao, Zhi Chen -- Part II. Allergenic Sources and Allergens. Overview of Allergen Sources in China / Zhao-Wei Yang, Zhong-Shan Gao, Ying-Tao Ma [and others] -- Allergen Protein Families and Cross-Reactivity / Luud J.W.J. Gilissen, Zhong-Shan Gao -- Seafood Allergens in China and Anti-allergenic Property of Seaweeds / Zhen-Xing Li, Hong Lin -- Food Allergen Epitopes / Hong-Bing Chen, Jin-Yan Gao -- Recombinant Allergens and Applications / Ying-Tao Ma, Zhao-Wei Yang, Zhong-Shan Gao -- Part III. Diagnosis. The CREATE Project: Development of Certified Reference Materials for Allergenic Products and Validation of Methods for Their Quantification / R. van Ree, M.D. Chapman, F. Ferreira [and others] -- Diagnosis of Skin Allergy Diseases / Huan Qian, Min Zheng -- Novel Approaches for the In-Vitro Diagnosis of Type I Allergies / Margrit Fooke -- Influence of Food Processing, Digestion and the Food Matrix on Allergenicity & Cellular Measures of Allergenicity / Y.M. Vissers, H.J. Wichers, H.F.J. Savelkoul -- Part IV. Therapies and Pharmacy. Immunotherapy of Asthma: From Basic Research to Clinical Practices / Hui-Ying Wang, Hua-Hao Shen -- Pharmacotherapy in Common Allergic Diseases / Erina M. Lin -- Immunotherapy in Allergic Skin Disease / Hao Cheng -- Traditional Chinese Medicine for Treating Food Allergy and Associated Eczema: From Research to Practice Perspective / Xiu-Min Li -- Immunomodulation by Food / Ingrid van der Meer, Jurriaan Mes, Amrah Weijn, Harry Wichers -- Prospective Studies on Mite (Dermatophagoides farinae) Allergen Immunotherapy in China / Ting-Huan Wen -- The Influence of Pollen Concentration on the Dispension of Antihistaminics and Corticosteroids to Hay Fever Patients / Arnold J.H. van Vliet, Hilde Tobi -- Part V. Hypoallergenic Products. In Search of Hypoallergenic Birch Trees: Characterization of PR-10 Genes from Eight Betula Species and Detection of Bet v 1 Isoforms in Birch Pollen Using a Combined Genomics- Proteomics Approach / M.J.M. Smulders, Martijn F. Schenk, Luud J.W.J. Gilissen -- Hypoallergenic Soybean, from Genes to Cultivar / Rong-Xia Guan, Xu-Qian Fang, Ru-Zhen Chang, Li-Juan Qiu -- Fruit Allergy and Genetic and Genomic Tools to Select Hypoallergenic Fruit Cultivars / Zhong-Shan Gao, Zhao-Wei Yang, Luud Gilissen -- Creating Hypoallergenic Crops through Genetic Modification / Xing-Jun Wang, Han Xia, Shuan-Tao Liu [and others] -- Acceptance of Natural and Genetically Modified Hypoallergenic Apples by Consumers with an Oral Allergy Syndrome (OAS) / I.M. van der Meer, M.F. Schenk, A.R.H. Fischer [and others] -- Cow's Milk Allergens and Technologies to Control Allergenicity / Yong-Kang Luo, Guan-Hao Bu -- Part VI Environment, Hygiene and Societal Issues. Prevalence of Asthma and Asthmatic Symptoms in Children in Relation to Environmental Factors --Epidemiological Studies in School Children in Taiyuan, China / Zhuo-Hui Zhao, Zhuan-Hua Wang, Zheng Zhang [and others] -- The Relationship of Food Allergies and Respiratory Allergies in Urban and Rural Chinese Children / Gary W.K. Wong, Yu-Zhi Chen, Jing Li, Nan-Shan Zhong -- Socio-Economic Issues Associated with Food Allergy / L.J. Frewer, J. Voordouw, M.F. Schenk [and others] -- The Association between Helminth Infections and Atopic Diseases / L.A.H. Hermsen.
  • 2006From: Springer
    Sadik Tuzun, Elizabeth Bent, editors.
  • 2017From: Springer
    Alexander A.A. Asea, Fabiana Geraci, Punit Kaur, editors.
    Extracellular vesicles in multiple sclerosis as possible biomarkers: dream or reality? / Maria Magdalena Barreca, Emanuele Aliotta, Fabiana Geraci -- Manipulation of oxygen and endoplasmic reticulum stress factors as possible interventions for treatment of multiple sclerosis: evidence for and against / Paul Eggleton, Gary R. Smerdon, Janet E. Holley, Nicholas J. Gutowski -- Heat shock proteins in multiple sclerosis / Ortan Pinar, Yildirim Akan Ozden, Erkizan Omur, Gedizlioglu Muhtesem -- Meaning of self in multiple sclerosis: implications for treatment and rehabilitation / Maciej Wilski, Tomasz Tasiemski -- Multiple sclerosis and EIF2B5: a paradox or a missing link / Insha Zahoor, Ehtishamul Haq, Ravouf Asimi -- Molecular genetic and epigenetic basis of multiple sclerosis / Zohreh Hojati -- Role of oligodendrocyte dysfunction in demyelination, remyelination and neurodegeneration in multiple sclerosis / Adriana Octaviana Dulamea -- Clinical neurophysiology of multiple sclerosis / Mario Habek, Ivan Adamec, Barbara Barun, Luka Crnošija, Tereza Gabelić, Magdalena Krbot Skorić -- Multiple sclerosis epidemiology in europe / Daiana Bezzini, Mario A. Battaglia -- Timing of future remyelination therapies and their potential to stop multiple sclerosis progression / Burcu Zeydan, Moses Rodriguez, Orhun H. Kantarci -- Neuroplasticity-based technologies and interventions for restoring motor functions in multiple sclerosis / Sofia Straudi, Nino Basaglia.
    Also available: Print – 2017
  • 2015From: Springer Protocols
    edited by Robert Weissert.
    Positional gene cloning in experimental populations / Maja Jagodic and Pernilla Stridh - - Generation of transgenic rats using lentiviral vectors / Holger M. Reichard and Henrike J. Fischer -- DNA vaccination techniques / Nicolas Fissolo, Xavier Montalban, and Manuel Comabella -- Peripheral blood mononuclear cells : isolation, freezing, thawing, and culture / Christine Riedhammer, Dagmar Halbritter, and Robert Weissert -- ELISPOT techniques / Niannian Ji and Thomas G. Forsthuber -- Isolation of central nervous system (CNS) infiltrating cells / Ilgiz A. Mufazalov and Ari Waisman -- Methods for ex vivo analysis of immune cell function from the central nervous system / Darryl G. Turner ... [et al.] -- Neurofilament light chain determination from peripheral blood samples / Marguerite Limberg ... [et al.] -- Detection of autoantibodies against myelin oligodendrocyte glycoprotein in multiple sclerosis and related diseases / Melania Spadaro and Edgar Meinl -- Myelinating cultures : an in vitro tool to identify demyelinating and axopathic autoantibodies / Maren Lindner and Christopher Linington -- In vivo visualization of (auto-) immune processes in the central nervous system of rodents / Christian Schlager ... [et al.] -- Optical coherence tomography to assess neurodegeneration in multiple sclerosis / Axel Petzold -- Experimental autoimmune encephalomyelitis in mice / Rachael L. Terry, Igal Ifergan, and Stephen D. Miller -- Actively induced experimental autoimmune encephalomyelitis in rats / Robert Weissert -- Experimental autoimmune encephalomyelitis in marmosets / S. Anwar Jagessar ... [et al.]-- Neuropathological techniques to investigate CNS pathology in experimental autoimmune encephalomyelitis (EAE) / Karin Steinbach and Doron Merkler -- Neuropathological techniques to investigate central nervous system sections in multiple sclerosis / Jan Bauer and Hans Lassmann.
  • 2014From: Wiley
    edited by Lawrence M. Samkoff, Andrew D. Goodman.
    Etiology / Sonya U. Steele and Ellen M. Mowry -- Immunopathogenesis of multiple sclerosis / Anne H. Cross and Laura Piccio -- Diagnostic process / Dalia Rotstein and Paul O'Connor -- MRI in diagnosis and disease monitoring / Maria I. Gaitan and Daniel S. Reich -- Relapsing MS : disease staging and therapeutic algorithms / Mohsen Khoshnam and Mark Freedman -- Progressive MS treatment algorithms / Megan H. Hyland and Jeffrey A. Cohen -- Sex-determined issues in multiple sclerosis / Callene Momtazee and Barbara Giesser -- Pediatric multiple sclerosis / Robert Thompson Stone and Brenda Banwell -- Complementary and alternative medicine : risks and benefits / Allen C. Bowling -- Symptomatic management of MS / Jessica Robb, Lawrence M. Samkoff, and Andrew D. Goodman -- Invisible symptoms of MS : fatigue, depression, and cognition / Leigh Charvet, Benzi Kluzer, and Lauren B. Krupp -- Rehabilitation / Nesanet S. Mitiku, Alexius E.G. Sandoval, and George H. Kraft -- Psychosocial adaptation to multiple sclerosis / David J. Rintell -- Transverse myelitis and acute disseminated encephalomyelitis / Benjamin M. Greenberg -- Neuromyelitis optica / Marcelo Matiello and Brian Weinshenker -- Neurosarcoidosis / Thomas F. Scott -- Lyme neuroborreliosis / Erica Patrick and Eric Logigian -- Neuro-Behçet syndrome / Aksel Siva and Sabahattin Saip -- Index.
  • 2013From: Springer
    Takashi Yamamura, Bruno Gran, editors.
    The availability of powerful genome-wide association study technology, during the last five years, has shown that most of the "new" MS susceptibility loci are immune-response genes. It is clear that there is much novelty in the field of MS immunology, which has served as an impetus to invest in new therapies. Notably, most if not all of these are immunotherapies. Even the equally exciting field of cell-based therapies and neuro-regeneration may well rely on cells or growth factors that are no less immunomodulators than restorative of myelin and neural cell function. Multiple Sclerosis Immunology looks at MS immunology as the basis for the present and-even more-the future of treatments for this complex autoimmune condition. Both editors are immunologists, as well as clinical neurologists, and appreciate the importance of a sustained dialogue between basic and clinical scientists to ensure that "translation" is real and not just virtual.
  • 2014From: ScienceDirect
    Diana Boraschi and Albert Duschl.
    Nanoparticles and the Immune System provides a reference text for toxicologists, materials scientists and regulators and covers the key issues of interaction of nanomaterials with the immune system. The book discusses several issues that toxicologists and regulators need to know: identification of endpoints that are relevant for assessing hazard, evaluating impact on immunologically frail populations, and how to evaluate chronic/cumulative effects. In addition, the book addresses the possibility of turning the immunomodulating properties of certain nanomaterials to our advantage.
  • v. 1-3, 2008-2010.From: Springer
    v. 2, 2009From: Springer
    v. 3, 2010From: Springer
    edited by Vassil St. Georgiev, Karl A. Western, John J. McGowan.
    v. 1. Frontiers in research -- v. 2. Impact on Global Health -- v. 3. Intramural research.
  • 2016From: Springer
    Eric Vivier, James Di Santo, Alessandro Moretta, editors.
    Transcriptional control of NK cells -- Development, homeostasis, and heterogeneity of NK cells -- Diversification and functional specialization of human NK cell subsets -- Dynamic regulation of NK cell responsiveness -- NK cells and cancer immunoediting -- Sweet is the memory of past troubles: NK cells remember -- Lessons from NK cell definiencies in the mouse -- Probing human NK cell biology using human immune system (HIS) mice -- Haploidentical haematopoietic stem cell transplantation: role of NK cells and effect of cytomegalovirus infections -- The past, present, and future of NK cells in hematopoietic cell transplantation and adoptive transfer -- Index.
  • 2010From: Springer
    Jacques Zimmer, editor.
  • 2012From: Springer
    Masaki Terabe, Jay A. Berzofsky, editors.
    Introduction : mechanisms of NKT-cell-mediated adjuvant activity and function of iPS-derived NKT cells / Masaru Taniguchi ... [et al.] -- Structure and recognition of antigens for invariant NKT cells / Bo Pei and Mitchell Kronenberg -- Invariant NKT cell-based vaccine strategies / John-Paul Jukes ... [et al.] -- Immune regulation of tumor immunity by NKT cells / Jessica J. O'Konek, Jay A. Berzofsky, and Masaki Terabe -- The regulation of CD1d+ and CD1d- tumors by NKT cells : the roles of NKT cells in regulating CD1d+ and CD1d- tumor immunity / Jianyun Liu, Gourapura J. Renukaradhya, and Randy R. Brutkiewicz -- DC-based immunotherapy targeting NKT cells / Shin-ichiro Fujii and Kanako Shimizu -- Therapeutic approaches utilising NKT cells / Stephen R. Mattarollo and Mark J. Smyth -- NKT cells or cancer patients and how models can inform therapeutic plans / Mark A. Exley, Lydia Lynch, and Michael Nowak -- Understanding the role of natural killer T cells in hematologic malignancies : progress and challenges / Natalia Neparidze and Madhav V. Dhodapkar -- Clinical trials with alpha-galactosylceramide (KRN7000) in advanced cancer / Famke L. Schneiders ... [et al.] -- Clinical trials of invariant natural killer T cell-based immunotherapy for cancer / Shinichiro Motohashi, Yoshitaka Okamoto, and Toshinori Nakayama.
  • 2006From: Springer
    edited by Gad Loebenstein and John Peter Carr.
  • 2012From: Springer
    edited by Hans U. Lutz.
    Naturally occurring IgM antibodies to oxidation-specific epitopes / Christoph J. Binder -- Naturally occurring autoantibodies to apoptotic cells / Keith B. Elkon and Gregg J. Silverman -- Naturally occurring antibodies directed against carbohydrate tumor antigens / Reinhard Schwartz-Albiez -- Naturally occurring antibodies as therapeutics for neurologic disease : can human monoclonal IgMs replace the limited resource IVIG? / Arthur E. Warrington ... [et al.] -- Nature and nurture of catalytic antibodies / Sudhir Paul ... [et al.] -- Naturally occurring autoantibodies in mediating clearance of senescent red blood cells / Hans U. Lutz -- Naturally occurring autoantibodies against ss-amyloid / Jan-Philipp Bach and Richard Dodel -- Multi-faceted role of naturally occurring autoantibodies in fighting pathogens / Hicham Bouhlal and Srini Kaveri -- Immunoregulation by naturally occurring and disease-associated autoantibodies : binding to cytokines and their role in regulation of T-cell responses / Claus H. Nielsen and Klaus Bendtzen -- Modulation of dendritic cells and regulatory T cells by naturally occurring antibodies / Jaap Kwekkeboom -- Control of B cells expressing naturally occurring autoantibodies / Jean Louis Pasquali and Thierry Martin -- Granulocyte death regulation by naturally occurring autoantibodies / Stephan Von Gunten and Hans-Uwe Simon -- Naturally occurring autoantibodies mediate ischemia/reperfusion-induced tissue injury / Sherry D. Fleming -- How immune complexes from certain IgG NAbs and any F(ab')2 can mediate excessive complement activation / Hans U. Lutz -- The natural autoantibody repertoire in newborns and adults : a current overview / Asaf Madi ... [et al.] -- Antibody polyspecificity : what does it matter? / Jordan D. Dimitrov, Anastas D. Pashov, Tchavdar L. Vassilev -- Positive and negative selection of natural autoreactive B cells / Richard R. Hardy and Kyoko Hayakawa -- Naturally occurring antibodies/autoantibodies in polyclonal immunoglobulin concentrates / Peter J. Späth and Hans U. Lutz.
    Also available: Print – 2012
  • 2011From: Springer
    [editors] Rafi Ahmed, Tasuku Honjo, Editors.
    TIM-3 and its regulatory role in immune responses / Chen Zhu, Ana C. Anderson and Vijay K. Kuchroo -- Role of PD-1 in regulating T-cell immunity / Hyun-Tak Jin, Rafi Ahmed and Taku Okazaki -- The role of IL-10 in regulating immunity to persistent viral infections / Elizabeth B. Wilson and David G. Brooks -- Inhibitory Ly49 receptors on mouse natural killer cells / Mark T. Orr and Lewis L. Lanier -- Immunoregulatory roles for Fc receptor-like molecules / Götz R.A. Ehrhardt and Max D. Cooper -- Fc[gamma]Rs in health and disease / Falk Nimmerjahn and Jeffrey V. Ravetch -- TGF-[beta] function in immune suppression / Akihiko Yoshimura and Go Muto.
  • 2012From: Springer Protocols
    edited by Myron Christodoulides.
    Neisseria meningitidis: biology, microbiology, and epidemiology -- Classification and pathogenesis of meningococcal infections -- Detection of Neisseria meningitidis in cerebrospinal fluid using a multiplex PCR and the luminex detection technology -- Generating knock-out and complementation strains of Neisseria meningitidis -- Identification and functional characterization of sRNAs in Neisseria meningitidis -- Expression, purification, and crystallization of neisserial outer membrane proteins -- Genome-scale metabolic models: reconstruction and analysis -- TMT labelling for the quantitative analysis of adaptive responses in the meningococcal proteome -- Meningococcal ligands and molecular targets of the host -- In vivo imaging of meningococcal disease dynamics -- Methods for studying Neisseria meningitidis biofilms -- Laminar-flow chamber assay for measuring bacterial adhesion under shear stress -- Techniques to measure pilus retraction forces -- Human dendritic cell culture and bacterial infection -- Hydrogen-deuterium exchange coupled to mass spectrometry to investigate ligand-receptor interactions -- Visualising PAMP-PRR interactions using nanoscale imaging -- Transcriptome analyses in the interaction of Neisseria meningitidis with mammalian host cells -- Use of the pan-Neisseria microarray and experimental design for transcriptomics studies of Neisseria -- Analysis of parameters associated with prevention of cellular apoptosis by pathogenic Neisseriae and purified porins -- Analysis of the immune response to Nia meningitidis using a proteomics approach -- Antigen identification starting from the genome: a "reverse vaccinology" approach applied to MenB -- DNA vaccine strategy for effective antibody induction to pathogen-derived antigens.
  • 2012From: Springer
    Mia Levite, editor.
    Dopamine in the Immune System: Dopamine Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Immune and Neuropsychiatric Diseases -- Nerve Driven Immunity: Noradrenaline and Adrenaline -- Acetylcholine and Cholinergic Modulation of Immune Responses -- Glutamate in the Immune System: Glutamate Receptors in Immune Cells, Potent Effects, Endogenous Production and Involvement in Disease -- GABA Is an Effective Immunomodulatory Molecule in the Brain and in the Periphery -- The Effects of Opioids on Immune Cells, Functions and Diseases -- The Effects of Somatostatin on Immune Cells, Functions and Diseases -- Neuropeptide Y: The Story, the Players, the Outcomes -- Vasoactive Intestinal Peptide: Immune Mediator and Potential Therapeutic Agent -- Nerve-Driven Immunity: The Effects of Neurotransmitters on Immune Cells, Functions and Disease -- CGRP -- The Effects of Cannabinoids on Immune Cells, Responses and Diseases.
  • Jose Antonio Gomez Aguilera.
    The outcomes of most viral infections are controlled by many genetic loci whose interactions are complex and difficult to predict. To characterize the genes that predispose to viral persistence, I carried out a genetic analysis of a murine susceptibility locus termed Tmevp3. Mice that carry the SJL/J-derived Tmevp3 locus become persistently infected, whereas mice carrying the B10.S-derived locus clear the infection. My investigation revealed that a long noncoding RNA, lncRNA, transcript named NeST RNA was the most polymorphic gene in the locus. I found that a spliced version of NeST RNA was abundant in T cells of SJL/J mice and not expressed in B10.S mice. To test whether expression of this lncRNA was the cause of viral persistence, I developed transgenic mice that expressed NeST RNA in B10.S mice. Indeed, NeST RNA alone was sufficient to confer viral persistence. To investigate the function of NeST RNA in T cells, I tested whether NeST regulates its neighboring genes, IL-22 and IFN-[gamma]. CD8+ T cells from mice carrying the SJL/J-Tmevp3 locus were found to produce greater amounts of IFN-[gamma], suggesting that NeST RNA might functions as an enhancer lncRNA. Indeed, transgenic expression of NeST lncRNA induced higher of IFN-[gamma] after T cell stimulation. Results from a collaborative study revealed NeST RNA functions in trans, localize to the nucleus, associates with the histone modifying complex component WDR5, and induces accumulation of histone 3 lysine 4 trimethylation (H3K4me3) at the Ifng locus. I also found that the Tmevp3 locus controls lethality from Salmonella. However, I found that in this model the SJL/J allele, which increases viral persistence, conferred decrease susceptibility for pathogenesis. As was the case in the viral susceptibility model, transgenic NeST RNA expression was sufficient to recapitulate this susceptibility phenotype. To test for any effects of NeST RNA in the inflammatory response to pathogen antigens, I carried out septic shock assays using the bacterial component LPS. I found that mice expressing NeST RNA survived more compared to the B10.S parental strain. Take together these data suggest that during immune challenge NeST RNA regulates the inflammatory response. To further analyze the effect of NeST RNA in the control of inflammation, NeST knockout mice were utilized. Deleting a 640 base pair region in the NeST promoter was found to abrogate gene expression and increase lethality to LPS sepsis. This difference in lethality coincided with larger abundances of numerous cytokines in mice lacking NeST RNA after LPS injections. However in the absence of an immune challenge, mice with an intact NeST gene showed higher basal levels of inflammatory cytokines, suggesting the basis of NeST RNA protection is a hormetic effect. Indeed, pre-treatment with low doses of LPS phenocopies the endotoxin tolerance effect of NeST RNA. Understanding how NeST RNA controls the timing and magnitude of cytokine secretion by T cells may provide new venues for therapeutic intervention to various inflammatory diseases.
  • Matthew Ryan Clutter.
    Target identification is both a critical and difficult step in the drug discovery process. A novel approach is presented here that utilizes flow cytometry to: 1) identify small molecule signaling network probes, and 2) characterize the diverse network activation states they induce. Signaling events across the network are compared to functional responses to determine the way in which each signaling node influences a given function. Nodes that accurately predict cellular functions that drive disease are promising drug targets. The approach was applied to mast cells to determine which signaling molecules best predicted the degranulation, eicosanoid release, and cytokine secretion induced by stimulation of the cells with IgE and specific antigen crosslinking. Erk and Akt phosphorylation best predicted degranulation; Erk and cJun phosphorylation best predicted eicosanoid release; and Akt phosphorylation alone best predicted cytokine secretion. The results confirmed several known aspects of mast cell IgE-dependent signaling and revealed unknown associations to be tested in future work -- notably, that the cJun pathway plays a role in eicosanoid production and that the Akt pathway is a critical integration point for transcription of most or all cytokine genes. Overall, the results suggest that Erk and Akt are the most promising targets in the IgE signaling network for development of mast cell stabilizing drugs.
  • 2008From: Springer
    Klaus Eichmann.
  • 2016From: Springer
    Cris Constantinescu, Razvan Arsenescu, Violeta Arsenescu, editors.
    The immunology of the gastrointestinal system -- The enteric nervous system -- Microbial regulation of gastrointestinal immunity in health and disease -- Roles of substance P in gastrointestinal functions and neuroimmune interactions -- Immunomodulation by vasoactive intestinal polypeptide (VIP) -- Helicobacter pylori, experimental autoimmune encephalomyelitis, and multiple sclerosis -- Stress and the gastrointestinal system -- Nutrition, macrobiotics and the brain neuroinflammatory response -- Guillain-Barré syndrome and Campylobacter jejuni enteritis -- Gut microbiota: a possible role in the pathogenesis of multiple sclerosis -- Intestinal parasites and immunomodulation in neuroinflammatory disease -- Neurological complications of anti-TNF treatments and other neurological aspects of inflammatory bowel disease -- Intestinal bacterial antigens, toxin-induced pathogenesis and immune cross-reactivity in neuromyelitis optica and multiple sclerosis -- Targeting immunomodulatory agents to the gut-associated lymphoid tissue -- The neuroimmunology of gluten intolerance -- The neurology of autoimmune pernicious anaemia (subacute combined degeneration) -- The impact of multiple sclerosis on gastrointestinal system function -- The neurology of Whipple's disease.
  • 2009From: ScienceDirect
    volume editor, Gábor Jancsó.
  • 2009From: Springer
    edited by Allan Siegel, Steven S. Zalcman.
  • 2016From: Springer
    Susumu Kusunoki, editor.
    Part I. Basic Neuroimmunology -- 1. Cellular Immunity and multiple sclerosis: Current understanding -- 2. Glia and neuroimmunology -- 3. Animal model -- 4. Blood-brain barrier and blood-nerve barrier -- Part II. Clinical Neuroimmunology -- 5. Multiple Sclerosis: etiology and mechanism, with special reference to Asians -- 6. Multiple sclerosis: Diagnosis and treatment -- 7. Neuropsychological aspects of multiple sclerosis -- 8. Neuromyelitis optica: Diagnosis and treatment -- 9. Guillain-Barré syndrome: Epidemiology, diagnosis and treatment -- 10. Autoantibodies in Guillain-Barre syndrome -- 11. Fisher syndrome -- 12. POEMS syndrome -- 13. Treatment of myasthenia gravis after the 2014 Japanese clinical guideline -- 14. N-methyl-D-aspartate receptor antibody-associated autoimmune encephalitis -- 15. Hashimoto encephalopathy -- 16. Paraneoplastic neurological diseases -- 17. Antibodies to ganglionic acetylcholine receptor -- 18. Novel treatment.
  • 2007From: Springer
    S.R. Pandi-Perumal, Daniel P. Cardinali, Georgios Chrousos.
  • 2009From: Springer
    Richard D. Granstein, Thomas A. Luger, editors.
  • 2015From: Wiley
    edited by Samuel David.
    Immune response in the human central nervous system in multiple sclerosis and stroke / Hans Lassmann -- In vivo imaging of glial and immune cell responses in CNS injury and disease / Alexandre Paré and Steve Lacroix -- Roles of CD4 and CD8 T lymphocytes in multiple sclerosis and experimental autoimmune encephalomyelitis / Nathalie Arbour and Alexandre Prat -- Microglia and macrophage responses and their role after spinal cord injury / Antje Kroner, Andrew D. Greenhalgh, and Samuel David -- The complexity of the innate immune system activation in stroke pathogenesis / María Isabel Cuartero, Ignacio Lizasoain, María Angeles Moro, and Ivan Ballesteros -- Neuroinflammation in aging / Ashley M. Fenn, Diana M. Norden, and Jonathan P. Godbout -- Peripheral and central immune mechanisms in neuropathic pain / Ji Zhang -- Inflammation in the pathogenesis of inherited peripheral neuropathies / Janos Groh, Dennis Klein, Antje Kroner, and Rudolf Martini -- Obesity and neuroinflammation-associated mood and cognitive disorders / Nathalie Castanon, Giamal Luheshi, and Sophie Layé -- Viral infections of the central nervous system : pathogenic and protective effects of neuroinflammation / John G. Walsh and Christopher Power -- The interplay between the peripheral and local immune response in recovery from acute central nervous system injuries / Catarina Raposo and Michal Schwartz -- Inflammation and optic nerve regeneration / Lukas Andereggen, Ephraim F. Trakhtenberg, Yin Yuqin, and Larry I. Benowitz -- Effects of macrophages and monocytes in remyelination of the CNS / Muktha Natrajan, Bibiana Bielekova, Robin JM Franklin -- Microglial involvement in Rett syndrome / Noël C. Derecki, James C. Cronk, and Jonathan Kipnis -- The role of regulatory T cells and microglia in amyotrophic lateral sclerosis / David R. Beers, Weihua Zhao, Kristopher G. Hooten, and Stanley H. Appel -- Role of TNF-alpha in synaptic plasticity / Renu Heir and David Stellwagen -- Resolution mediators that control inflammation / Jan M. Schwab, Harald Prüss, and Charles N. Serhan.
  • 2014From: Wiley
    [edited by] Nicola Woodroofe and Sandra Amor.
    Immune privilege of the brain -- Innate immunity in the CNS : a focus on the myeloid cell -- Adaptive immune responses in the CNS -- Ageing and the immune response in the CNS -- Brain repair : the role of endogenous and transplanted neural stem cells -- Neuroinflammation in Alzheimer's, Parkinson's, and Huntington's diseases -- CNS infections -- Neuroimmunology of amyotrophic lateral sclerosis -- Demyelinating disorders of the CNS -- Other autoimmune disorders : systemic lupus erythematosus, primary Sjogren's syndrome, gluten-related neurological dysfunction, and paraneoplastic neurological syndromes -- Inflammation in the pathogenesis of depression -- Immune responses in the CNS in epilepsy -- Inflammatory mediators and dysfunction of the neurovascular unit following ischaemia reperfusion -- Spinal cord injury -- Immune responses to tumours in the CNS.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.

Stanford Medicine

Lane Medical Library