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Allergy and Immunology

  • 2007 Springer
    Frosch, Peter J.; Le Coz, C.J; Lepoittevin, J.-P.
    Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
  • 2010 Springer
    Preedy, Victor R.; Watson, Ronald R.; Zibadi, Sherma.
  • 2014 Springer
    Chang, Christopher C.; Gershwin, M. Eric; Incaudo, Gary.
    Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
  • 2011
    Peng, Kaitian; Falkow, Stanley; Lewis, David B.; Monack, Denise M.; Schneider, David.
    Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
  • 2006 Springer Protocols
    Brandsma, Janet L.; Saltzman, W. Mark; Shen, Hong.
    DNA vaccine design / Janet L. Brandsma -- Design of plasmid DNA constructs for vaccines / Donna L. Montgomery and Kristala Jones Prather -- Vaccination with messenger RNA / Stave Pascolo -- A stress protein-facilitated antigen expression system for plasmid DNA vaccines / Petra Riedl ... [et al.] -- In vitro assay of immunostimulatory activities of plasmid vectors / Weiwn Jiang, Charles F. Reich, and David S. Pisetsky -- Delivery of DNA vaccines using electroporation / Shawn Babiuk, Sylvia van Drunen Littel-van den Hurk, and Lorne A. Babiuk -- Needle-free injection of DNA vaccines: a brief overview and methodology / Kanakatte Raviprakash and Kevin R. Porter -- Needle-free delivery of veterinary DNA vaccines / Sylvia van Drunen Littel-van den Hurk, Shawn Babiuk, and Lorne A. Babiuk -- Surface-modified biodegradable microspheres for DNA vaccine delivery / Mark E. Keegan and W. Mark Saltzman -- A dendrimer-like DNA-based vector for DNA delivery: a viral and nonviral hybrid approach / Dan Luo ... [et al.] -- Identification of compartments involved in mammalian subcellular trafficking pathways by indirect immunofluorescence / Anne Doody and David Putnam -- Adjuvant properties of CpG oligonucleotides in primates / Daniela Verthelyi -- Complexes of DNA vaccines with cationic, antigenic peptides are potent, polyvalent CD8+ T-cell stimulating immunogens / Petra Riedl, Jörg Reimann, and Reinhold Schirmbeck -- Prime-boost strategies in DNA vaccines / C. Jane Dale ... [et al.] -- Modifying professional antigen-presenting cells to enhance DNA vaccine potency / Chien-Fu Hung, Mu Yang, and T.C. Wu -- Replicase-based DNA vaccines for allergy treatment / Sandra Scheiblhofer ... [et al.] -- Immunological responses of neonates and infants to DNA vaccines / Martha Sedegah and Stepen L. Hoffman -- DNA vaccines for allergy treatment / Richard Weiss, Sandra Sheiblhofer, and Josef Thalhamer -- Protection from autoimmunity by DNA vaccination against T-cell receptor / Thorsten Buch and Ari Waisman -- The use of bone marrow-chimeric mice in elucidating immune mechanisms / Akiko Iwasaki -- A simple method for the production of plasmid DNA in bioreactors / Kristin Listner, Laura Kizer Bentley, and Michel Chartrain -- Practical methods for supercoiled pDNA production / John Ballantyne -- Production of plasmid DNA in industrial quantities according to cGMP guidelines / Joachim Schorr ... [et al.] -- Large-scale, nonchromatographic purification of plasmid DNA / Jason C. Murphy, Michael A. Winters, and Sangeetha L. Sagar -- Assuring the quality, safety, and efficacy of DNA vaccines / James S. Robertson and Elwyn Griffiths.
  • 2013 Springer
    Baldo, Brian A.; Pham, Nghia H.
    Adverse reactions to drugs and drug allergy: scope of this book --Classification and descriptions of allergic reactions to drugs -- Mechanisms of hypersensitivity -- Diagnosis of allergic reactions to drugs -- β-lacam antibiotics -- Other antimicrobial drugs -- Drugs and other agents used in anesthesia and surgery -- Opiod analgesic drugs -- Nonsteroidal anti-inflammatory drugs -- Contrast media -- Biologics -- Corticosteroids -- Drugs used for chemotherapy -- Proton pump inhibitors -- Postface-concluding remarks.
  • 2014 Springer
    Bosch, Xavier; Khamashta, Munther A.; Ramos-Casals, Manuel.
  • 2009 Springer
    Colloff, Matthew.
    "The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.
  • 2010
    Campbell, J. D.; Davis, Mark M.; Garcia, K. Christopher; Jones, Patricia; McDevitt, Hugh O.
    T cells will usually recognize any pathogen that threatens the body, despite the many different and constantly changing forms these pathogens can take. This is accomplished by the enormous diversity of T-cell receptors that are randomly generated during T-cell maturation. There are a number of distinct mechanisms that drive this diversity: one is the recombination of gene segments, (designated V, D, and J), from pools of many possible gene segments. Another is the addition and deletion of nucleotides at the gene segments joints (between the V, D, and J segments). This yields ~10^15 different possible T-cell receptors, which is many times greater that the number of T cells in the periphery of either mice (~10^8) or humans (~10^11). The T-cell receptor is formed from two polypeptide chains, α and β, each derived from separately rearranged gene segments. Each chain is composed of semi-randomly chosen gene segments. We utilized three transgenes, one limiting the α chain and two limiting the β chain. These progressively limited the number available gene segments of 100 Vα's to 1; 50 Jα's to 2; 30 Vβ's to 1; 2Dβ's to 1 and 13 Jβ's to 2. This reduced the number of gene segment combinations from a theoretical 3,900,000 to 4 combinations. The addition and deletion of nucleotides at the gene segment joints is unaffected. In an in vivo CTL killing assay, the mice with these limited T cell repertoires are able to recognize most but not all of the antigenic peptides tested (9 of 11, in the most restricted mice). Their immunity to Listeria monocytogenes was reduced somewhat; but the LD50 of Yersinia pseudotuberculosis was not diminished by limiting T-cell repertoire, and viral load after murine cytomegalovirus infection was similar to wild type. The limited repertoire mice also exhibited less vigorous alloreactive responses to some haplotypes, indicating that alloreactive responses are influenced by V gene segment compatibility with the MHC. We conclude that N and P nucleotide addition is sufficient for the bulk of T-cell immunity, at least in the laboratory setting. Limiting V(D)J gene segment choice, despite eliminating some T-cell specificities, does not have a dramatic effect on T-cell immunity.
  • 2010
    Mabery, Eric Maurice; Martinez, Olivia M.; Schneider, David; Sonnenburg, Justin; Utz, Paul J.
    Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known concerning where eiger is produced and what genes are regulated by eiger. Here we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. Using tissue specific knockdowns we found that eiger expression in the fat body is required for all of the phenotypes we observed in eiger null mutant flies. This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium. We further characterized the eiger response using transcriptional arrays. We found that the eiger regulates a number of genes involved in metabolism and hormonal signaling during an immune response. How these genes are involved in the immune response is not clear. Finally we examined the role of age related decline of the immune system in D. melanogaster during bacterial infection. We found that vigor and tolerance are reduced when old flies are challenged with a variety of bacterial pathogens.
  • 2015 Springer Protocols
    Hnasko, Robert.
  • 2009 Springer Protocols
    Crowther, J. R.
  • 2012 ClinicalKey
    Actor, Jeffrey K.
    This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
  • 2012 Future Med
    Reed, Steven G.
    Emulsion-based vaccine adjuvants / Christopher Fox, Darrick Carter & Steven G. Reed -- MF59® : an oil-in-water adjuvant / Jennifer Whitaker, Nadine Rouphael & Mark J. Mulligan -- AS03 adjuvant / Woolf T. Walker & Saul N. Faust -- Innovations in emulsion technology / Christopher B. Fox, Darrick Carter, Susan L. Baldwin, & Steven G. Reed -- Index.
  • 2014 Springer
    Mackay, Ian M.; Rose, Noel R.
  • 2014 Springer
    Mackay, Ian M.; Rose, Noel R.
  • 2005 Springer
    Vohr, Hans-Werner.
  • 2013
    Rhodes, John.
    "At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio"--Provided by publisher.
  • 2008 ScienceDirect
    Jara, Luis J.; Walker, Sara E.
    This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
  • 2015 Springer
    Koch-Nolte, Friedrich.
    Part I. Evolution and detection of endogenous ADP-ribosylation. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system / L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer -- Identification and analysis of ADP-ribosylated proteins / Friedrich Haag and Friedrich Buck -- Part II. ADP-ribosylation by ARTCs (R-S-E ARTs). Photorhabdus luminescens Toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine / Klaus Aktories, Gudula Schmidt and Alexander E. Lang -- Reaction mechanism of mno-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein / Hideaki Tsuge and Toshiharu Tsurumura -- Regulation of nitrogenase by reversible mono-ADP-ribosylation / Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells / Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte and Sahil Adriouch -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish / Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto and Masahiko Watanabe -- Part III. ADP-ribosylation by ARTDs (H-Y-E ARTs). Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family / Ana Filipa Pinto and Herwig Schüler -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 / Max Kaufmann, Karla L.H. Feijs and Bernhard Lüscher -- Regulation of nucleocytoplasmic transport by ADP-tibosylation: the emerging role of Karyopherin-[Beta]1 mono-ADP-ribosylation by ARTD15 / Maria Di Girolamo -- Index.
  • 2010 Springer
    Dauphinee, Shauna M.; Karsan, Aly.
    Also available: Print – 2010
  • 2010 Springer
    Quinn, Peter J.; Wang, Xiaoyuan.
    Endotoxins: Lipopolysaccharides of Gram-negative bacteria / X. Wang and P.J. Quinn -- Purification and characterization of lipopolysaccharides / X. Wang ... [et al.] -- Endotoxins: Relationship between structure, function, and activity / K. Brandenburg, A.B. Schromm and T. Gutsmann -- The diversity of the core oligosaccharide in lipopolysaccharides / A. Silipo and A. Molinaro -- Salmonella-regulated lipopolysaccharide modifications / S.M. Richards, K.L. Strandberg and J.S. Gunn -- The variation of O antigens in Gram-negative bacteria / L. Wang, Q. Wang and P.R. Reeves -- Regulators of TLR4 signaling by endotoxins / A.F. McGettrick and L.A.J. O'Neill -- Membrane partitioning: Is location everything when it comes to endotoxin recognition? / M. Triantafilou and K. Triantafilou -- Endotoxin detection - from limulus amebocyte lysate to recombinant Factor C / J.L. Ding and B. Ho -- The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni / A.P. Moran -- The role of pseudomonas lipopolysaccharide in cystic fibrosis airway infection / S.M. Moskowitz and R.K. Ernst -- Development of small-molecule endotoxin sequestering agents / S.A. David and D. Sil -- Development of an anti-endotoxin vaccine for sepsis / A.S. Cross -- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants / C.B. Fox ... [et al.] -- Targeting endotoxin in the treatment of sepsis / J.-S. Rachoin, C.A. Schorr and R.P. Dellinger -- Lipopolysaccharides in rhizobium-legume symbioses / R.W. Carlson, L.S. Forsberg and E.L. Kannenberg -- Lipopolysaccharides and plant innate immunity / G. Erbs ... [et al.].
  • 2013 Springer
    Pascual, Marién; Roa, Sergio.
    Introduction -- Immune System and Atopic Disorders -- Epigenetics -- Epigenetics, Environment, and Allergic Diseases -- Conclusions and Future Perspectives.
  • 2011 Springer
    Ballestar, Esteban.
    An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.
    Also available: Print – 2011
  • 2012 Springer
    Murre, Cornelis.
    Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
  • 2009 Springer Protocols
    Morris, Glenn E.; Reineke, Ulrich; Schutkowski, Mike.
    What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.
  • 2015 Springer
    v. 2 Springer
    Münz, Christian.
  • 11973.
    Roitt, Ivan Maurice.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011
    Rakhra, Kavya; Felsher, Dean; Krams, Sheri M.; Kuo, Calvin Jay; Levy, Ronald.
    Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
  • 2015 Springer
    Allen, Herbert B.
    Atopic dermatitis has been called "the itch that rashes", and this book reveals what causes the "itch". It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. The Etiology of Atopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.
  • 2012
    Cohen, Sheldon G.; Samter, Max.
    PrintStatus: Not Checked OutLane Catalog Record
    Antiquity -- 1190 to about 1889 -- 1890 to about 1910 -- 1911 to about 1940 -- 1941 to about 1969 -- 1970 to about 1987.
  • 2015 Springer
    Gattorno, Marco.
    This book, written by very well known opinion leaders in the field, covers all aspects of familial Mediterranean fever, the most common monogenic autoinflammatory disease. The opening chapters explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies. A large part of the book is then devoted to a detailed description of the typical and atypical clinical presentations, the disease course, and potential complications in both pediatric and adult patients. Guidance is provided on the measurement of disease severity and the management of patients in daily practice. The advice regarding treatment is based on the best currently available evidence and attention is also paid to important emerging treatments. The book is part of Springer?s series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Monogenic autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Familial Mediterranean fever itself is due to a mutation in the MEFV gene, which codes for the protein pyrin; it is characterized by periodic fever and episodes of painful inflammation in the abdomen, chest, and joints. Familial Mediterranean Fever will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with the disease.
  • 2014 Springer
    Daëron, M.; Nimmerjahn, Falk.
    This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
  • 2014 Springer
    Maibach, Howard I.; Thyssen, Jacob P.
    Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Burks, Wesley; Eigenmann, Philippe A.; James, John M.
    1. Overview of mucosal immunity and development of oral tolerance / Corinne Keet, Robert Wood -- 2. Food antigens / E. N. Clare Mills, Philip E. Johnson, Yuri Alexeev -- 3. Epidemiology of food allergy / Katrina J. Allen, Jennifer J. Koplin -- 4. Clinical overview of adverse reactions to foods / John M. Kelso -- 5. Atopic dermatitis and food allergy / Tamara T. Perry, Debra D. Becton, Stacie M. Jones -- 6. Food-induced urticaria and angioedema / Julia Rodriguez, Jesús F. Crespo -- 7. Pollen-food syndrome / Antonella Muraro, Cristiana Alonzi -- 8. Respiratory tract and food allergy / John M. James -- 9. Food-induced anaphylaxis and food associated exercise-induced anaphylaxis Motohiro Ebisawa -- 10. Eosinophilic gastroenteropathies (eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis) / Dan Atkins, Glenn T. Furuta -- 11. Food protein-induced enterocolitis syndrome, food protein-induced enteropathy, proctocolitis, and infantile colic / Stephanie Ann Leonard, Anna Nowak-Węgrzyn -- 12. Approach to the clinical diagnosis of food allergy / Jonathan O'B. Hourihane -- 13. In vivo and in vitro diagnostic methods in the evaluation of food allergy / S. Allan Bock -- 14. Oral food challenge procedures / Gideon Lack, George Du Toit, Mary Feeney -- 15. Management of food allergy and development of an anaphylaxis treatment plan / Jacqueline Wassenberg, Philippe Eigenmann -- 16. Patient education and empowerment / Kim Mudd, Robert Wood -- 17. Future therapies for food allergies / Anna Nowak-Węgrzyn, Hugh A. Sampson -- 18. Natural history and prevention of food allergy / Scott H. Sicherer, Atsuo Urisu -- 19. Diets and nutrition: cross-reacting food allergens / Vicki McWilliam -- 20. Diagnostic and therapeutic dilemmas: adverse reactions to food additives, pharmacologic food reactions, psychological considerations related to food ingestion / John O. Warner.
  • 2014 CRCnetBASE
    Sicherer, Scott H.
    Chapter 1. Clinical manifestations of food allergy / Jonathan M. Spergel and Hemant P. Sharma -- Chapter 2. Prevalence, triggers, and cross-reactivity / Lynette P. Shek and Katrina (Katie) J. Allen -- Chapter 3. Acute reactions and anaphylaxis / Corinne Keet and Julie Wang -- Chapter 4. Skin conditions associated with food allergy / Tamara T. Perry, A. Wesley Burks, and Stacie M. Jones -- Chapter 5. Gastrointestinal conditions associated with food allergy / Mirna Chehade and Seema Aceves -- Chapter 6. Respiratory conditions associated with food allergy / John M. James -- Chapter 7. Diagnostic testing / Maeve Kelleher, S. Allan Bock, and Jonathan O'B Hourihane -- Chapter 8. The oral food challenge procedure / Sally Noone and Amal H. Assa'ad -- Chapter 9. Dietary management / Marion Groetch -- Chapter 10. Managing food avoidance within the home and outside the home, and lifestyle issues / Jennifer S. Kim, Eyal Shemesh, and Michael C. Young -- Chapter 11. Pharmacologic reactions to food and reactions to food additives / Matthew J. Greenhawt, Timothy J. Franxman, and Ronald A. Simon -- Chapter 12. Prevention / George Du Toit, David M. Fleischer, and Gideon Lack -- Chapter 13. Natural course / Jessica H. Savage and Robert A. Wood -- Chapter 14. Future diagnostics and therapies / Anna Nowak-Wegrzyn and Hugh A. Sampson -- Chapter 15. Practical resources for physicians and patients / Todd A. Mahr and Maria L. Acebal.
  • 2015 Karger
    Ballmer-Weber, Barbara. K.; Ebisawa, Motohiro; Vieths, Stefan; Wood, Robert A.
  • 2011 Springer
    Spanel-Borowski, Katharina.
    The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
  • 2006 Springer
    Ahmed, Rafi; Pulendran, B.
    TLR signaling / S. Akira -- Dendritic cells : translating innate to adaptive immunity / R.M. Steinman and H. Hemmi -- Helper T cell-regulated B cell immunity / L.J. Mcheyzer-Williams, L.P. Malherbe, and M.G. McHeyzer-Williams -- T cell memory / J.T. Tan an C.D. Surh -- The privacy of T cell memory to viruses / R.M. Welsh ... [et al.] -- Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA / M.J. McCluskie and A.M. Krieg.
    Also available: Print – 2006
  • 2013 Ovid
    Paul, William E.
    Section I: Introduction to immunology -- chapter 1. The immune system / William E. Paul -- chapter 2. History of immunology / Steven Greenberg -- Section II: Organization and evolution of the immune system -- chapter 3. Lymphoid tissues and organs / Eitan M. Akirav ... [et al.] -- chapter 4. Evolution of the immune system / Martin F. Flajnik and Louis Du Pasquier -- Section III: Immunoglobulins and B-lymphocytes -- chapter 5. Immunoglobulins: structure and function / Harry W. Schroeder Jr., David Wald, and Neil S. Greenspan -- chapter 6. Immunoglobulins: molecular genetics / Edward E. Max and Sebastian Fugmann -- chapter 7. Antigen-antibody interactions and monoclonal antibodies / Jay A. Berzofsky and Ira J. Berkower -- chapter 8. B-lymphocyte development and biology / Richard R. Hardy -- chapter 9. B-lymphocyte receptors, signaling mechanisms, and activation / Akanksha Chaturvedi ... [et al.] -- chapter 10. B-lymphocyte responses / Michael McHeyzer-Williams -- Section IV: T-lymphocytes -- chapter 11. T-cell antigen receptors / Mark M. Davis and Yueh-Hsiu Chien -- chapter 12. Mechanisms of T-lymphocyte signaling and activation / Takashi Saito -- chapter 13. T-lymphocyte developmental biology / Ellen V. Rothenberg and Ameya Champhekar -- chapter 14. Peripheral T-lymphocyte responses and function / Marc K. Jenkins -- Section V: The intersection of innate and adaptive immunity -- chapter 15. The innate immune system / Luke A. J. O'Neill -- chapter 16. Dendritic cells / Kang Liu, Michel C. Nussenzweig -- chapter 17. Natural killer cells / Wayne M. Yokoyama -- chapter 18. CD1d-restricted natural killer T-cells / Albert Bendelac -- chapter 19. Macrophages and phagocytosis / Siamon Gordon -- chapter 20. Granulocytes and mast cells / Patrizia Scapini ... [et al.] -- chapter 21. The major histocompatibility complex and its proteins / David H. Margulies ... [et al.] -- chapter 22. Antigen processing and presentation / Ted H. Hansen and Paul A. Roche -- Section VI: Induction, regulation, and effector functions of the immune response -- chapter 23. Immunogenicity and antigen structure / Jay A. Berzofsky and Ira J. Berkower -- chapter 24. Rc receptors and their role in immune regulation and inflammation / Jeffrey V. Ravetch and Falk Nimmerjahn -- chapter 25. Type I cytokines and interferons, and their receptors / Warren J. Leonard -- chapter 26. The interleukin-1 family / Charles A. Dinarello and Mihai G. Netea -- chapter 27. Tumor necrosis factor-related cytokines in immunity / Carl F. Ware -- chapter 28. Chemokines / Philip M. Murphy -- chapter 29. Helper T-cell differentiation and plasticity / John J. O'Shea -- chapter 30. Programmed cell death / Andrew L. Snow and Michael J. Lenardo -- chapter 31. Immunologic memory / Shane Crotty, Susan M. Kaech, and Stephen P. Schoenberger -- chapter 32. Immunologic tolerance / Christopher C. Goodnow and Pamela S. Ohashi -- chapter 33. Regulatory/suppressor T-cells / Ethan M. Shevach -- chapter 34. The mucosal immune system / Yasmine Belkaid -- chapter 35. Neurophysiologic reflex mechanisms in immunology / Sangeeta S. Chavan and Kevin J. Tracey -- chapter 36. Complement / B. Paul Morgan -- chapter 37. Cell-mediated cytotoxicity / Judy Lieberman -- Section VII: Immunity to infectious agents -- chapter 38. The immune response to parasites / Thomas A. Wynn ... [et al.] -- chapter 39. Immunity to viruses / Hildegund C. J. Ertl -- chapter 40. Immunity to intracellular bacteria / Anca Dorhoi, Stephen T. Reece, and Stefan H. E. Kaufmann -- chapter 41. Immunity to extracellular bacteria / Moon H. Nahm and Jannet Katz -- chapter 42. Immunology of human immunodeficiency virus infection / Douglas S. Kwon and Bruce D. Walker -- chapter 43. Vaccines / Ennio De Gregorio ... [et al.] -- Section VIII: Immunologic mechanisms in disease -- chapter 44. Autoimmunity and autoimmune diseases / Ken T. Coppieters, Matthias G. von Herrath, and Dirk Homann -- chapter 45. Immunologic mechanisms of allergic disorders / Marsha Wills-Karp and Ian Lewkowich -- chapter 46. Transplantation immunology / Megan Sykes, Kathryn Wood, and David H. Sachs -- chapter 47. Cancer immunology / Hans Schreiber -- chapter 48. Inborn errors of immunity / Jean-Laurent Casanova, Mary Ellen Conley, and Luigi D. Notarangelo.
  • 2008 Ovid
    Paul, William E.
    Also available: Print – 2008
  • 2002 Karger
    Breitenbach, Michael; Crameri, Reto; Lehrer, Samuel B.
    Also available: Print – 2002
  • 2005 Springer
    Fidel, Paul L.; Huffnagle, Gary B.
    Also available: Print – 2005
  • 2001 Karger
    Bergstresser, Paul R.; Takashima, A.
    T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotection
    Also available: Print – 2001
  • 2005 Springer
    Prud'homme, Gérald J.
    Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
    Also available: Print – 2005
  • 2012 Springer
    Scheiblhofer, Sandra; Thalhamer, Josef; Weiss, Richard D.
  • 2012 Springer
    Yamanaka, Ryuya.
    Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.
    Also available: Print – 2012
  • 2014
    Agache, Ioana; Akdis, Cezmi A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 Springer
    Axford, John S.
    Also available: Print – 2005
  • 2009 Springer
    Wardle, E. N.
  • 2012 Springer Protocols
    Kalyuzhny, Alexander E.
    Unique strengths of ELISPOT for T cell diagnostics / Paul V. Lehmann and Wenji Zhang -- The impact of harmonization on ELISPOT assay performance / Sylvia Janetzki and Cedrik M. Britten -- Equine ELISPOT assay to study secretion of IFN[gamma] and IL-4 from peripheral blood mononuclear cells / Jodi Hagen [and others] -- Utilization of feline ELISPOT for mapping vaccine epitopes / Jeffrey R. Abbott [and others] -- Analyzing cellular immunity to AAV in a canine model using ELISPOT assay / Zejing Wang [and others] -- Dual- and triple-color fluorospot / Niklas Ahlborg and Bernt Axelsson -- ELISPOT assay as a tool to study oxidative stress in lymphocytes / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay for neuroscience research : studying TNF[alpha] secretion from microglial cells / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay as a tool to study the effects of stem cells on cytokine secretion / Jun-Seop Shin and Chung-Gyu Park -- Combining ELISPOT and ELISA to measure amounts of cytokines secreted by a single cell / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- How ELISPOT morphology reflects on the productivity and kinetics of cells' secretory activity / Alexey Y. Karulin and Paul V. Lehmann -- Mathematical algorithms for automatic search, recognition, and detection of spots in ELISPOT assay / Sergey S. Zadorozhny and Nikolai N. Martynov -- Objective, user-independent ELISPOT data analysis based on scientifically validated principles / Wenji Zhang and Paul V. Lehmann -- Statistical analysis of ELISPOT assays / Marcus Dittrich and Paul V. Lehmann -- Response determination criteria for ELISPOT : toward a standard that can be applied across laboratories / Zoe Moodie [and others] -- Detection of Vaccinia virus-specific IFN[gamma] and IL-10 secretion from human PBMCs and CD8 T cells by ELISPOT / Benjamin J. Umlauf [and others] -- ELISPOT assays to enumerate bovine IFN-[gamma]-secreting cells for the development of novel vaccines against bovine tuberculosis / Martin Vordermeier and Adam O. Whelan -- IL-7 addition increases spot size and number as measured by T-SPOT. TB® / Marsha L. Feske [and others] -- Overview of membranes and membrane plates used in research and diagnostic ELISPOT assays / Alan J. Weiss.
  • 2008 CRCnetBASE
    Donnenberg, Albert David; O'Gorman, Maurice R. G.
    Overview of immunity / James D. Folds -- Statistics of immunological testing / Albert D. Donnenberg -- Human immunoglobulins / Robert G. Hamilton -- The complement system / Patricia C. Giclas -- Cellular immunology : monitoring of immune therapies / Theresa L. Whiteside -- Understanding clinical flow cytometry / Albert D. Donnenberg and Vera S. Donnenberg -- Leukemia and lymphoma immunophenotyping and cytogenetics / Maria A. Proytcheva -- Guidelines for the use of flow cytometry in the management of patients infected with the human immunodeficiency virus type-1 and the acquired immunodeficiency syndrome / Maurice R.G. O'Gorman -- Role of flow cytometry in the diagnosis and monitoring of primary immunodeficiency disease / Maurice R.G. O'Gorman -- Detection and characterization of the T-cell receptor repertoire / Gulbu Uzel -- Human leukocyte differentiation antigens, cluster of differentiation : past, present, and future / Maurice R.G. O'Gorman -- Immunologic diagnosis of autoimmunity / Noel R. Rose -- Autoimmune and immune-mediated diseases of the gastrointestinal tract / Stefano Guandalini, Mala Setty, and Bana Jabri -- Serologic testing for infectious diseases / John L. Schmitz -- Molecular techniques applied to infectious diseases / Jennifer S. Goodrich and Melissa B. Miller -- Cytokines : regulators of immune responses and key therapeutic targets / Barbara Detrick, Chandrasekharam N. Nagineni, and John J. Hooks -- Measuring human cytokines / Holden T. Maecker -- The human major histocompatibility complex and DNA-based typing of human leukocyte antigens for transplantation / Susana G. Marino, Andrés Jaramillo, and Marcelo A. Fernández-Viña -- Relevance of antibody screening and crossmatching in solid organ, hematopoietic stem cell transplantation, and blood transfusion / Chee L. Saw ... [et al.] -- Functional assessment of immunosuppression : monitoring posttransplant alloreactivity with flow cytometric mixed lymphocyte cocultures / Chethan Ashok Kumar ... [et al.].
    Also available: Print – 2008
  • 2015 Springer
    Lin, Fan; Prichard, Jeffrey.
    In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. ℗ℓ Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. ℗ℓ Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
  • 2011 Springer
    Lin, Fan.
    Quality management and regulation / Jeffrey Prichard -- Technique and troubleshooting of antibody testing / Fan Lin and Jianhui Shi -- Overview of automated immunohistochemistry / Jeffrey Prichard, Angela Bitting, and Joe Myers -- Automated staining : Dako perspective / Ole F. Rasmussen and Andreas Schønau -- Automated staining : Ventana perspective / Angela Sattler -- Tissue microarray / Myra Wilkerson and Erin Powell -- Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens / Fan Lin and Haiyan Liu -- Exfoliative cytopathology / Steven Meschter and Jan F. Silverman -- Predictive markers of breast cancer : ER, PR, and HER2 / Jeffrey Prichard, David Hicks, and Elizabeth Hammond -- Central and peripheral nerve system tumors / Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller -- Thyroid and parathyroid gland / Haiyan Liu, Fan Lin, and Ronald A. DeLellis -- Adrenal gland / Hanna G. Kaspar -- Salivary gland and other head and neck structures / Conrad Schuerch -- Lung, pleura, and mediastinum / Kai Zhang and Phillip Cagle -- Breast / Haiyan Liu -- Uterus / Hanna G. Kaspar -- Ovary / Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson -- Prostate gland / Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai -- Urinary bladder / Myra Wilkerson -- Kidney / Fan Lin and Ximing J. Yang -- Testis and paratesticular tissues / Myra Wilkerson -- Pancreas and ampulla / Fan Lin and Hanlin L. Wang -- Liver, bile ducts, and gallbladder / Jeffrey Prichard and Fan Lin -- Upper gastrointestinal tract / Jinhong Li and Fan Lin -- Lower gastrointestinal tract and microsatellite instability / Jinhong Li and Fan Lin -- Soft tissue and bone tumors / Shaobo Zhu and Markku Miettinen -- Lymph node / Xiaohong (Mary) Zhang and Nadine S. Aguilera -- Bone marrow / R. Patrick Dorion and Xiaohong (Mary) Zhang -- Infectious diseases / Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner -- Skin / Tammie Ferringer -- Application of direct immunofluorescence for the skin and mucosal biopsies : a practical review / William B. Tyler -- In situ hybridization in surgical and cytologic specimens / Hong Yin and Barbara Paynton.
  • v. 1-, 2004- ScienceDirect
  • 2009 Springer
    Franceschi, Claudio; Fülöp, Tamas; Hirokawa, Katsuiku; Pawelec, G.
  • 2010
    Tan, Shumin; Amieva, M. R.; Falkow, Stanley; Nelson, W. J.; Theriot, Julie A.
    Helicobacter pylori is a bacterium that chronically infects the stomachs of more than half the human population, in some cases leading to serious diseases such as gastric cancer and ulcers. H. pylori intimately interact with the gastric epithelial surface, but much remains unknown about its life on the cell surface. The bacterium possesses several tools for its close interaction with the gastric epithelia, including a type IV secretion system, through which the virulence factor CagA is directly translocated into host cells. This dissertation focuses on how H. pylori's close interactions with the epithelial cells allows it to modify the apical cell surface to turn it into a replicative niche for the bacterium. Using live-cell microscopy to follow the fate of individual bacteria on the cell surface, we find that H. pylori is able to utilize the apical cell surface as a replicative niche, even in conditions that do not support the growth of free-swimming bacteria. Experiments with a polarized epithelial model system show that the bacterium's major virulence factors CagA and VacA both play important roles in enabling H. pylori growth and microcolony formation on the apical cell surface, by mediating perturbation of host cell polarity and intracellular trafficking processes. We find that iron is one important micronutrient that H. pylori acquires from host cells during colonization of the polarized epithelium. CagA and VacA act in concert to affect the polarized process of transferrin/transferrin receptor recycling and iron uptake in the host cells, resulting in the mis-sorting of a subset of the transferrin/transferrin receptor complex to the colonizing bacteria on the apical cell surface. This process is functionally important for the bacteria, as downregulation of transferrin receptor expression resulted in a decreased ability of H. pylori to colonize the polarized epithelium. These studies establish the cell surface as a replicative niche, which presents challenges that require bacterial adaptation for its successful utilization. Our findings also illustrate the concept that contact-dependent bacterial virulence factors may be used for the perturbation of host cell physiology for the bacterium's benefit, allowing acquisition of needed factors directly from host cells, and colonization of the apical cell surface.
  • 2012 ClinicalKey
    Hsi, Eric D.
    Section 1. Non-neoplastic disorders -- section 2. Lymphomas -- section 3. Leukemias, chronic myeloproliferative neoplasms, and myelodysplasia -- section 4. Disorders of histiocytes, mast cells, plasma cells, spleen, and ancillary techniques.
  • 2012 Springer
    Lee, Benhur; Rota, Paul A.
    Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K. T. Wong and C. T. Tan -- Henipaviruses in Their Natural Animal Hosts / D. J. Middleton and H. M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
  • 2013 Springer
    Bartenschlager, Ralf.
    Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
  • 2008 Springer
    Jirillo, E.
    Innate immunity in type C hepatitis / Tetsuo Takehara and Norio Hayashi -- Mechanisms of interferon action and resistance in chronic hepatitis C virus infection: lessons learned from cell culture studies / Srikanta Dash ... [et al.] -- Immunological parameters influencing adaptive immune responses to the hepatitis C virus / Patrick Bertolino, Geoffrey W. McCaughan, and David G. Bowen -- Immune responses against the hepatitis C virus and the outcome of therapy / Paul Klenerman and Eleanor Barnes -- Other microbial components associated with hepatitis C virus infection: their effects on interferon- a/ribavirin treatment / Luigi Amati, Vittorio Pugliese, and Emilio Jirillo -- Interferon-induced effector proteins and hepatitis C virus replication / Michael Frese and Eva Dazert -- Treatment of chronic hepatitis C with different genotypes / James Fung, Ching-Lung Lai, and Man-Fung Yuen -- Interferon treatment of hepatitis C virus infection: from basic biology to clinical application / Norihiro Furusyo, Masayuki Murata, and Jun Hayashi -- Interferon-based therapy for hepatitis C virus infections / Ming-Lung Yu and Wan-Long Chuang -- Treatment of chronic hepatitis C in "difficult-to-treat" patients in the clinical setting / Ana Moreno, Rafael Bárcena, and Carmen Quereda -- Effects of combined IFN-alpha/ribavirin treatment in HCV disease-related progression / Davide Festi ... [et al.] -- Pegylated interferons: clinical applications in the management of hepatitis C infection / S. James Matthews and Christopher McCoy.
  • 2014 Springer
    Brasier, Allan R.
    Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.
    Also available: Print – 2014
  • 2010 Springer
    Thurmond, Robin L.
    One hundred years of histamine research / Katherine Figueroa and Nigel Shankley -- Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs -- Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu -- Abstract -- Histamine in allergic rhinitis / Thomas Taylor-Clark -- The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.] -- The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate -- Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer -- Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff -- Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy -- Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula -- Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas -- The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond.
    Also available: Print – 2010
  • 2015 Springer
    Jarisch, Reinhart.
    Histamine is an important mediator of allergic diseases such as hay fever and bronchial asthma, food allergies, urticaria, and drug hypersensitivity. Knowledge of histamine as a cause of numerous non-allergic symptoms and signs is, however, limited. In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, atopic dermatitis, and osteoporosis. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages, and intolerance to red wine. Diagnosis of histamine intolerance is explained, and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the conditions mentioned above and also consider the relation of histamine to vitamin B6 and the specific immunotherapy of allergies. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance, and by assisting in the selection of therapeutic measures.
  • 2014 Karger
    Bergmann, Karl-Christian; Ring, Johannes.
  • 2009 ScienceDirect
    Silverstein, Arthur M.
    Also available: Print – 2009
  • 2014 ScienceDirect
    Nagy, Zoltan A.
    A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author.
  • 2011 Springer
    Plotkin, Stanley A.
    "The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases. However, no vaccine development has been easy and there is an interesting story attached to each. The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries. The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine."--Publisher's website.
  • 2009 Springer
    Paul, Robert H.; Sacktor, Ned Charlton; Tashima, Karen Tokie; Valcour, Victor.
    Neurocognitive changes in AIDS: evolution of treatment of HIV infection / Erna Milunka Kojic and Charles C.J. Carpenter -- Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes, and epidemiology of hepatitis C infection among HIV-positive individuals / Karen T. Tashima and Aadia I. Rana -- New insights into HIV neuropathogenesis / Tory P. Johnson and Avindra Nath -- Neuropathological findings associated with long-term HAART / Iain C. Anthony and Jeanne E. Bell -- Biomarkers of HIV-related central nervous system disease / Bruce James Brew and Scott Letendre -- Neuroimaging among HIV-infected patients: current knowledge and future directions / David F. Tate ... [et al.] -- The assessment of HIV-associated neurocognitive disorders: new challenges in the HAART era / Lucette A. Cysique and Bruce J. Brew -- The changing face of HIV-associated cognitive and neuropsychiatric disturbance / Ron Cohen -- Youth with HIV/AIDS: neurobehavioral consequences / Susannah Allison, Pamela L. Wolters, and Pim Brouwers -- Co-occurrence of HIV, hepatitis C, and substance use disorders: effects on brain functioning / Raul Gonzalez, Phillip J. Quartana, and Eileen M. Martin -- The functional impact of HIV-associated neuropsychological decline / Matthew J. Wright ... [et al.] -- Adjunctive therapy for long-term support of cognitive impairment / Joshua T. Dearborn ... [et al.] -- HIV-1 genetic diversity and its biological significance / Michael M. Thomson -- Opportunistic infections in the brain in developing countries / Marcus Tulius T. Silva and Beatriz Grinsztejn -- Impact of Clade diversity on neuropsychological outcomes / Robert Paul ... [et al.] -- The effects of aging on HIV disease / Robert C. Kalayjian and Lena Al-Harthi -- Neuropsychology of healthy aging / Molly E. Zimmerman and Adam M. Brickman -- Interactions between advanced age and HIV cognitive impairment / Victor Valcour and Aaron M. McMurtray.
  • 2014 Springer
    Pantophlet, Ralph.
    Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.-- Source other than Library of Congress.
  • 2010
    Hotson, Andrew Neely; Amieva, M. R.; Jones, Patricia; Nolan, Garry P.; Relman, David A.
    The immune response to a pathogen is a complex interplay between host factors aimed to eradicate the pathogen, and microbe virulence proteins designed to subvert the host. To successfully combat a pathogen, the host must identify the insult and activate an immune response tailored to eliminate the specific microbe. This entails cell signaling at the level of innate immunity to detect the pathogen and mount an immediate non-specific response, while also communicating to bystander cells to shape the scope of the adaptive arm of immunity. The work herein investigates how the intracellular signaling network is activated and perturbed across cell types and hematopoietic tissues during bacterial infection. An introductory background on the current knowledge in the field of immune signaling is provided in chapter 1. Antigen presenting cells detect pathogenic motifs via pattern recognition receptors including toll-like receptors. This triggers an intracellular signaling cascade with specific transcriptional consequences, including the production of cytokines. In turn, these cytokines alert additional cell types to activate specific signal transducer and activator of transcription (STAT) transcription factor family members. Thus, detection of a microbe initiates rapid signaling across leukocytes to set the stage for the immune response. Chapter 2 focuses on cell signaling experiments in a murine model for the onset of sepsis. Mice were acutely challenged with avirulent E. coli and Listeria monocytogenes to study the host response without pathogenic manipulation of host signaling by bacterial virulence factors. Bacterial challenge causes macrophages and dendritic cells to become attenuated in their ability to respond to TLR agonists, a hallmark of endotoxin tolerance. Also, it induces global dampening of the STAT response to cytokines across all cell types; splenocytes from challenged mice poorly respond to cytokine stimulation. Cytokines secreted by antigen presenting cells act on bystander cells and induced negative feedback, including SOCS expression and receptor endocytosis that prevent further STAT activation. Thus, bacterial recognition causes host immune activation followed by subsequent suppression of signaling. The work in chapter 3 transitions to a model of chronic infection with pathogenic Salmonella typhimurium. In addition to examining the innate response, this model enables investigation of adaptive immunity by monitoring the activation of T cells, their cytokine response profile, and TH-biasing by the transcription factors they express and cytokines they produce. During chronic infection, B cells and effector T cells undergo expansion but not contraction over the first 30 days, demonstrating that the immune system establishes a new equilibrium. However, the degree of cell expansion, as well as the ability of these cells to respond to cytokine, is quite variable across mice. These mice also have varied levels of bacterial burden, and the shape of the immune response denotes disease severity. High bacterial load is associated with trademarks of innate immunity such as elevated neutrophil numbers, serum cytokine levels, and the dampened STAT signaling observed during bacterial challenge in chapter 2. In contrast, the mice that control infection are enriched for markers of adaptive T cell immunity: high numbers of TH1 effector T cells, T cell proliferation, ability to respond to cytokines, and fewer regulatory T cells. Therefore, a strong adaptive response is correlated with containing the infection, while an innate response is indicative of high bacterial levels. This thesis concludes in chapter 4, with a discussion of how the findings fit in the context of cell signaling in other disease states. Leukemia and lymphomas, diseases of uncontained cell growth, are characterized by hyperactive cell signaling. In contrast, an activated immune response, such as during auto-immunity or in cancer infiltrating T cells, is marked by repressed ability to respond to cytokines. As inhibited cytokine responses were also observed during bacterial challenge and during severe chronic infection, it appears that a commonality amongst disease that activate an immune response is negative feedback to dampen further signaling and restrict inflammation.
  • 2013 Springer
    Chhatwal, G. Singh.
    Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
  • 2008 Springer
    Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2008
  • 2013 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2013
  • 2009 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Shiga-toxin producing escherichia coli and the hemolytic uremic syndrome / Christina K. Ahn, Nicholas J. Holt, Phillip I. Tarr -- Global epidemiology of pneumococcal disease - new prospects for vaccine control / Vinicius C. Antao, William P. Hausdorff -- Current concepts of the pathogenesis of RSV bronchiolitis / Louis Bont -- How can we eradicate pertussis / James D. Cherry -- Recognition and management of encephalitis in children / James D. Cherry -- Microbiology and management of pleural empyema / Julia Clark -- Pneumococcal conjugate vaccines probe studies / Ron Dagan -- New findings in primary immunodeficiency / Andrew R. Gennery, Andrew J. Cant -- Routine use of influenza vaccine / David Isaacs -- Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for gram positive infections / Sheldon L. Kaplan -- Significance of serotype replacement for pneumococcal disease and antibiotic resistance / Keith P. Klugman -- Childhood intra-thoracic tuberculosis / Ben J. Marais -- Antibiotic pipeline in pediatrics / George H. McCracken -- Paediatric drug development and clinical trials / E. David G. McIntosh -- Influenza in pregnancy / Shelly McNeil, Beth Halperin, Noni MacDonald -- Febrile neutropenia in children with cancer / Stéphane Paulus, Simon Dobson -- PANDAS syndrome / Michael E. Pichichero -- Fever in the returned paediatric traveller / F. Andrew I. Riordan -- Molecular diagnostics of primary immunodeficiencies / Mirjam van der Burg, Menno C. van Zelm, Jacques J.M. van Dongen -- Human genetic resistance to malaria / Thomas N. Williams.
    Also available: Print – 2009
  • 2010 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Also available: Print – 2010
  • 2011 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    The value of vaccination / David E. Bloom -- Recent trends in global immunisation / Gustav J.V. Nossal -- New advances in typhoid fever vaccination strategies / Zulfiqar A. Bhutta ... [et al.] -- Prevention of vertical transmission of HIV in resource-limited countries / Catherine M. Wilfert ... [et al.] -- Pneumonia in children in developing countries / Frank Shann -- Darwin, microbes and evolution by natural selection / E. Richard Moxon -- Human herpesvirus 6 / Charles G. Prober -- Advances in the diagnosis and management of central venous access device infections in children / Asha Bowen and Jonathan Carapetis -- Moraxella catarrhalis-pathogen or commensal? / Christoph Aebi -- Anaerobic infections in children / Itzhak Brook -- Encephalitis diagnosis and management in the real world / Sarah S. Long -- Toxic shock syndrome-evolution of an emerging disease / James K. Todd -- Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency / Mirjam van der Burg ... [et al.] -- Mumps is back : why is mumps eradication not working? / Noni Macdonald ... [et al.] -- Neonatal herpes simplex virus infections: where are we now? / Clara Thompson and Richard Whitley -- Rational approach to pediatric antifungal therapy / William J. Steinbach -- Antiviral therapy of CMV disease in children / Mike Sharland ... [et al.] -- Infectious hazards from pets and domestic animals / Mona Al-Dabbagh and Simon Dobson -- Novel technology to study co-evolution of humans and Staphylococcus aureus: consequences for interpreting the biology of colonisation and infection / Alex van Belkum -- A practical approach to eosinophilia in a child arriving or returning from the tropics / Penelope Bryant and Nigel Curtis.
    Also available: Print – 2011
  • 2011 Springer
    Curtis, Nigel; Finn, Adam; Pollard, Andrew J.
    Our Time of Pestilence: Purchasing Immunity and Ignoring the Misery of Others / Philip Alcabes -- Neonatal Meningitis: Can We Do Better? / Paul T. Heath, Ifeanyichukwu O. Okike and Clarissa Oeser -- Approaches Towards Avoiding Lifelong Antiretroviral Therapy in Paediatric HIV Infection / Philip J. R. Goulder and Andrew J. Prendergast -- How Short Is Long Enough for Treatment of Bone and Joint Infection? / Markus Pääkkönen and Heikki Peltola -- What's New in Diagnostic Testing and Treatment Approaches for Mycoplasma pneumoniae Infections in Children? / Ken B. Waites -- Pigs, Poultry, and Pandemic Influenza: How Zoonotic Pathogens Threaten Human Health / Thijs Kuiken, Ron Fouchier, Guus Rimmelzwaan, Judith van den Brand and Debby van Riel, et al. -- Kingella kingae Infections in Children: An Update / Inbal Weiss-Salz and Pablo Yagupsky -- Influenza Pandemics / Ruth Elderfield and Wendy Barclay -- Management of Shunt Related Infections / Mona Al-Dabbagh and Simon Dobson -- Nontuberculous Lymphadenopathy in Children: Using the Evidence to Plan Optimal Management / Julia E. Clark -- Pediatric Brucellosis: An (Almost) Forgotten Disease / Pablo Yagupsky -- Q Fever: Still More Queries than Answers / Corine E. Delsing, Adilia Warris and Chantal P. Bleeker-Rovers -- Rickettsioses in Children: A Clinical Approach / Emmanouil Galanakis and Maria Bitsori -- What is the Evidence Behind Recommendations for Infection Control? / Christina Gagliardo and Lisa Saiman -- What Do We Know About How to Treat Tuberculosis? / Ben J. Marais -- Bacterial Meningitis in Childhood / Manish Sadarangani and Andrew J. Pollard -- Mycobacterium marinum Infection / Marc Tebruegge and Nigel Curtis.
    Also available: Print – 2011
  • 2014 Springer
    Horsnell, William.
    "Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"--Publisher's description.
    Also available: Print – 2014
  • 2008 Springer
    Kitamura, Daisuke.
    Recognition of pathogens: toll-like receptors / Satoshi Uematsu, Shizuo Akira -- Strategies of natural killer (NK) cell recognition and their roles in tumor immunosurveillance / C. Andrew Stewart, Eric Vivier -- Recent progress on paired immunoglobulin-like receptors / Hiromi Kubagawa ... [et al.] -- Self-nonself recognition through B-cell antigen receptor / Daisuke Kitamura -- How do T cells discriminate self from nonself? / Catherine Mazza, Bernard Malissen -- Fc receptors / Falk Nimmerjahn, Jeffrey V. Ravetch -- Self and nonself recognition by coreceptors on B lymphocytes: regulation of B lymphocytes by CD19, CD21, CD22, and CD72 / Kozo Watanabe, Takeshi Tsubata -- Co-receptors in the positive and negative regulation of T-cell immunity / Helga Schneider, Christopher E. Rudd.
  • 2006 Springer
    Khamashta, Munther A.
  • 2013 Springer
    Hughes, Graham R. V.; Khamashta, Munther A.
    Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) responsible for 1 in 5 young (under 45) strokes a major cause of early heart attacks responsible for 1 in 5 deep vein thromboses an important cause of migraine.
  • 2008 Springer
    Dessain, Scott K.
    Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.] -- Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.] -- Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.] -- Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.] -- The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.] -- Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].
    Also available: Print – 2008
  • 2014 Springer Protocols
    Steinitz, Michael.
    Human monoclonal antibodies : the residual challenge of antibody immunogenicity / Herman Waldmann -- Technical and ethical limitations in making human monoclonal antibodies (an overview) / Mark C. Glassy and Rishab Gupta -- Therapeutic human monoclonal antibodies in inflammatory diseases / Sotirios Kotsovilis and Evangelos Andreakos -- Therapeutic human monoclonal antibodies against cancer / Jamie Jarboe, Anumeha Gupta, and Wasif Saif -- Polyclonal and monoclonal antibodies in clinic / Bharath Wootla, Aleksandar Denic, and Moses Rodriguez -- Production of human monoclonal Antibodies by the Epstein-Barr virus method / Michael Steinitz -- Humanization and simultaneous optimization of monoclonal antibody / T. Kuramochi, T. Igawa, H. Tsunoda, and K. Hattori -- Chimeric Antibodies / Kohei Kurosawa, Waka Lin, and Kunihiro Ohta -- Recombinant genetic libraries and human monoclonal antibodies / Jarrett J. Adams, Bryce Nelson, and Sachdev S. Sidhu -- Production of stabilized scFv antibody fragments in the E. coli bacterial cytoplasm / Lilach Vaks and Itai Benhar -- Construction and production of an IgG-like tetravalent bispecific antibody, IgG-single-chain Fv fusion / Dan Lu and Zhenping Zhu -- Construction of human antibody gene libraries and selection of antibodies by phage display / André Frenzel [and others] -- Antigen-specific human monoclonal antibodies from transgenic mice / Susana Magadán Mompó and África González-Fernández -- Phage display technology for human monoclonal antibodies / Cecilia Deantonio [and others] -- Antigen-specific in vitro immunization : a source for human monoclonal antibodies / Kosuke Tomimatsu and Sanetaka Shirahata -- Methods for radiolabelling of monoclonal antibodies / Vladimir Tolmachev, Anna Orlova, and Karl Andersson -- Purification of human monoclonal antibodies and their fragments / Thomas Müller-Späth and Massimo Morbidelli -- Idiotype-specific intravenous immunoglobulin (IVIG) for therapy of autoimmune diseases / Miri Blank, Tomer Bashi, and Yehuda Shoenfeld.
  • 2011 Future Med
    Franco, Eduardo L.
    Human papillomavirus vaccines / Eduardo L. Franco -- Pathobiology and immunology of human papillomavirus / Margaret Stanley -- Overview of clinical evidence : the quadrivalent vaccine Gardasil / Suzanne M Garland -- Overview of clinical evidence : Cervarix -- Tino F. Schwarz -- HPV vaccines : public health and clinical guidelines / F. Xavier Bosch -- Perspectives for prophylactic and therapeutic vaccination for HPV-induced lesions / Shreya Kanodia & W. Martin Kast.
  • 2014 Springer Protocols
    Poli, Guido; Vicenzi, Elisa.
    Virion attachment and entry : HIV gp120 env biotinylation, gp120 env, or integrin ligand-binding assay / Claudia Cicala and James Arthos -- CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5[alpha] / Gongpu Zhao and Peijun Zhang -- The fate of HIV-1 capsid : a biochemical assay for HIV-1 uncoating / Yang Yang, Jeremy Luban, and Felipe Diaz-Griffero -- The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells / Amy E. Hulme and Thomas J. Hope -- Imaging HIV-1 nuclear pre-integration complexes / Anna Cereseto and Mauro Giacca -- HIV-1 reverse transcription / Andrea Cimarelli and Jean-Luc Darlix -- RNase H : specificity mechanisms of action, and antiviral target / Karin Moelling, Felix Broecker, and John E. Kerrigan -- HIV-1 chromatin, transcription, and the regulatory protein Tat / Laurence Colin, Eric Verdin, and Carine Van Lint -- HIV-1 Rev function and RNA nuclear-cytoplasmic export / Alan Cochrane -- HIV-1 accessory proteins : Nef / Anke Heigele [and three others] -- HIV-1 accessory proteins : VpR / Richard Y. Zho and Michael I. Bukrinsky -- HIV-1 accessory proteins : Vpu and Vif / Amy Andrew and Klaus Strebel -- SIVSM/HIV-2 Vpx proteins : function and uses in the infection of primary myeloid cells / Gregory Berger and Andrea Cimarelli -- Imaging of HIV assembly and release / Barbara Müller and Jacomine Krijnse-Locker -- HIV-1 isolation from infected peripheral blood mononuclear cells / Stefania Dispinseri [and four others] -- Determination of HIV-1 co-receptor usage / Mariangela Cavarelli and Gabriella Scarlatti -- The macrophage and HIV : basic concepts and methodologies / Suzanne Gartner -- HIV infection of dendritic cells / Najla Nasr [and three others] -- Histocultures (tissue explants) in human retrovirology / Anush Arakelyan [and four others] -- Single-copy quantification of HIV-1 in clinical samples / Ann Wiegand and Frank Maldarelli -- Quantification of total HIV1-DNA in peripheral blood mononuclear cells / Christine Rouzioux, Adeline Mélard, and Véronique Avéttand-Fénoël -- HIV-1 based lentiviral vectors / Ying Poi Liu and Ben Berkhout -- Quantification of miRNA by poly(A)-RT-qPCR arrays and verification of target sites in HIV-1 using a one-LTR infectious molecular clone / Zachary A. Klase, Laurent Houzet, and Kuan-Teh Jeang -- Investigating human T cell lymphotropic retrovirus (HTLV) Tax function with molecular and immunophenotypic techniques / Greta Forlani, Roberto S. Accolla, and Giovanna Tosi -- Proviral load determination of HTLV-1 and HTLV-2 in patients' peripheral blood mononuclear cells by real-time PCR / Claudio Casoli, Elisabetta Pilotti, and Umberto Bertazzoni -- Quantitative analysis of human T-lymphotropic virus type 1 (HTLV-1) gene expression using nucleo-cytoplasmic fractionation and splice junction-specific real-time RT-PCR (qRT-PCR) / Ilaria Cavallari, Francesca Rende, and Vincenzo Ciminale.
  • 2009 Springer
    Rook, Graham A. W.
    Also available: Print – 2009
  • 2008 ScienceDirect
    Besedovsky, Hugo O.; Chrousos, George P.; Del Rey, Adriana.
  • 2012 Springer
    Rainsford, K. D.
    Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
  • 2015 Springer
    Curotto de Lafaille, Maria A.; Lafaille, Juan José.
    Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
  • 2014 Springer
    Kawa, Shigeyuki; Kawano, Mitsuhiro; Okazaki, Kazuichi; Stone, John H.; Umehara, Hisanori.
    IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.
  • 2013 Springer
    Di Padova, Franco; Quesniaux, Valérie; Ryffel, Bernhard.
    The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.
    Also available: Print – 2013
  • 2009 CRCnetBASE
    Cruse, Julius M.; Lewis, R. E.
    Also available: Print – 2009
  • 2011
    Vasey, Adrianne Elizabeth; Chawla, Ajay; Engleman, Edgar G.; Negrin, Robert S.; Utz, Paul J.
    Allogeneic hematopoietic cell transplantation (HCT) is an excellent model for the controlled study of adoptively transferred cells in the induction and progression of numerous immune responses in vivo, with the added benefit that these cells can be tracked, identified, and re-isolated. Using this model, we conducted four distinct sets of studies related to the trafficking and function of immune cells in allogeneic responses. In our first project, we focused on the early events of T cell activation leading to the induction of Graft-versus-Host Diesease (GVHD) in a murine model of major histocompatibility complex (MHC)-matched transplantation. Although it is well known GVHD occurs in MHC-matched transplants, little is known about donor T cell activation kinetics in minor-mismatched models. Yet, because these models better approximate clinical transplantation, it is critical to understand how GVHD develops across minor barriers. To investigate temporal and spatial events of GHVD development, side-by-side transplants were conducted into major and minor-mismatched recipients using hematopoietic cells from the same donor mouse strain. In both models, T cells home to nodal sites by day 3, proliferate, and exit to GVHD target tissues by day 6. Additionally, expression of homing and activation markers was equivalent for all markers examined on day 3. However, tissue migration and proliferation were reduced in the minor model. And by day 6, minor-mismatched T cells had increased CD62L retention and reduced P-selectin and CD44 expression. We also found fewer MHC-matched T cells producing interferon-[gamma] (IFN-[gamma]) and tumor necrosis factor-[alpha] (TNF-[alpha]). Our data show that very early events of donor T cell activation are similar in both models, suggesting that delays in GVHD onset across minor barriers arise from temporal differences in the effector phase, rather than the initiation phase, of GVHD. For our second project, we examined the ability of transplanted natural killer (NK) cells to impact GVHD in MHC-matched transplants as allogeneic NK cells are already known to suppress GVHD in transplants across major histocompatibility barriers. Since NK cells can lyse host antigen-presenting cells (APCs) in these transplants due to disparities in MHC class I expression between the recipient and donor, thus reducing the activation of donor T cells, it is thought that this is primary mechanism of NK-mediated reductions in GVHD. However, in MHC-matched transplants, MHC class I expression is shared between donor and host, protecting host APCs from lysis. Previous work from our laboratory has shown that NK cells can also reduce GVHD, in MHC-mismatched transplants, through the inhibition and lysis of autologous donor T cells that have upregulated expression of NKG2D activating ligands. As such, we wondered whether this mechanism may also reduce GVHD in transplants across minor histocompatibility barriers. Our data demonstrate that donor NK cells are able to improve survival and reduce GHVD disease severity in the more clinically relevant model of MHC-matched transplantation. As allorecognition and lysis of MHC-mismatched host APCs is not possible in this model, NK cells must be mediating their benefits through alternate mechanisms. Although we did find that NK cells were capable of reducing the proliferation of syngeneic T cells in an MLR using irradiated MHC-matched splenocytes as stimulators, we were unable to find evidence for the direct inhibition, or lysis, of donor T cells by NK cells in vivo. It seems likely that this was at least partially due to the much lower number of NK cells used in these studies compared to the previous reports. Additionally, as NK cells may impact T cells that are homeostatically proliferating differently then they impact T cells proliferating in response to antigen, it will be critical for future studies to clearly separate these two populations, especially given the reduced frequency of alloreactive T cells in MHC-matched models. Perhaps then we will be able to identify the mechanisms of donor NK mediated reductions in GVHD. In our third project, we studied the in vivo ability of NK cells to clear tumor. NK cells have natural cytotoxicity and cytokine production capabilities, and are known to mount potent responses against both viruses and tumor cells. Preclinical data in combination with results from clinical trials of haploidentical killer immunoglobulin-like receptor (KIR)-ligand mismatched bone marrow transplantation led to interest in the use of adoptive NK immunotherapy for the treatment of malignancy. Recent early-phase clinical trial results have shown that allogeneic NK cells can be safely administered after chemotherapy and/or irradiation but have also demonstrated limited persistence of the infused NK cells. Additionally, in the absence of control arms, it has been difficult to determine whether tumor clearance is due to the preparative regimen, or due to actual immune mediated effects. Here, using several murine models of NK-sensitive hematologic malignancy, we trace the fate of adoptively infused NK cells and show that NK cells traffic to tumor sites but fail to control tumor growth. NK cells rapidly down-regulate effector functions and activating receptor expression upon homeostatic proliferation and upon tumor exposure in syngeneic as well as allogeneic settings. This dysfunction is likely cell-intrinsic as it is accompanied by down-regulation of the canonical transcription factors Eomesodermin and T-bet, and is not impacted by depletion of regulatory T cells from the tumor milieu. These results demonstrate that NK cell capability is intrinsically limited and cannot be relied upon for adoptive anti-tumor immunotherapy. As such, novel approaches may be required in order to circumvent the described dysfunction phenotype. Lastly, we attempted to deplete dendritic cells (DCs) within the host to study impacts on the development of GVHD. To try to delineate whether there is a critical time window during which host DCs cells need to initiate GVHD, we conducted MHC-mismatched transplants into BALB/c mice that were chimeric for the CD11c DTR-GFP transgene in their hematopoietic system, to be able to control the deletion of host DCs at specific time points. Despite initial problems with DT lethality in the original transgenic mice, we were able to achieve successful, transient, depletion of host DCs using these chimeric mice made from the BM of transgenic donors. Although we found that DT treatment of transgenic mice 24 hours to harvesting their spleens for use as stimulators in an MLR greatly reduced allogeneic T cell proliferation, DT treatment of transgenic chimeric recipients prior to irradiation and transplantation with allogeneic T cells did not provide any protection from the development of GVHD, even with up to a 4 day delay in T cell administration and titrating T cell doses down to 1 x 105. In contrast, DT treated mice actually had reduced survival compared to transgenic chimeras given only PBS, suggesting that DC depletion may somehow enhance T cell proliferation. This may be partially due to negative impacts on the activation, expansion, and function of Tregs, which are known to have important cross-talk with DCs. These studies were further complicated by the fact that the chimeric transgenic mice had all previously undergone lethal TBI, as we found that previously irradiated recipients had reduced survival when transplanted with allogeneic T cells, regardless of whether or not they were transgenic of WT or whether they received DT or PBS, compared to mice that had never been irradiated previously. Additionally, since DC depletion is not 100% in these animals, we were unable to precisely determine the contribution of remaining cell types in the outcomes we observed. As such we were unable to conclude anything about the role of host DCs in the development of GVHD from these studies.
  • 2013 Springer Protocols
    Lenardo, Michael; Snow, Andrew L.
    Quantitating lymphocyte programmed cell death in vitro using simple kill assays / Lixin Zheng -- Fluorescence-activated cell sorting-based quantitation of T cell receptor restimulation-induced cell death in activated, primary human T cells / Gil Katz and Andrew L. Snow -- Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes / Joao Bosco Oliveira -- Determination of apoptosis sensitivity in specific T cell subsets from human peripheral blood by utilizing a multiparameter fluorescence-activated cell sorting-based technique / Bernice Lo and Madhu Ramaswamy -- Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation / Nelia Cordeiro and Nicolas Bidere -- Analyses of programmed cell death in dendritic cells / Min Chen, Lily Huang, and Jin Wang -- Detection of necrosis by release of lactate dehydrogenase Activity / Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa -- Assessment of CD4+ and CD8+ T cell responses using MHC class I and II tetramers / Sema Kurtulus and David Hildeman -- Homeostatic proliferation of mature T cells / Christopher E. Martin [and others] -- Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers / Liset Westera [and others] -- Real-time quantitative (RQ- )PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis / Menno C. van Zelm [and others] -- Molecular measurement of T cell receptor excision circles / Heather E. Lynch and Gregory D. Sempowski -- Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis / R. Anthony Barnitz [and others] -- Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders / Yu Zhang and Helen C. Su -- Flow cytometric measurement of SLAM-associated protein and x-linked inhibitor of apoptosis / Rebecca A. Marsh, Jack J. Bleesing, and Alexandra H. Filipovich -- In vitro suppression assay for functional assessment of human regulatory T cells / Dat Q. Tran.
  • 2009 Springer
    Krause, Walter; Naz, Rajesh K.
  • 2006 Springer
    Blumberg, R. S.; Neurath, M.
    Structure and function of the gut mucosal immune system / Reinhard Pabst and Hermann J. Rothkutter -- Functional aspects of the mucosal immune system / Cathryn Nagler-Anderson -- Recent progress in inflammatory bowel disease genetics / Judy H. Cho -- Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation / R. Balfour Sartor -- Experimental models of mucosal inflammation / Warren Strober and Ivan J. Fuss -- Overview of role of the immune system in the pathogenesis of inflammatory bowel disease / Thomas T. MacDonald and Giovanni Monteleone -- The role of the epithelial barrier in inflammatory bowel disease / Edward E.S. Nieuwenhuis and Richard S. Blumberg -- Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease / Francisco Leon ... [et al.] -- Alterations of T lymphocytes in inflammatory bowel diseases / Charles O. Elson, Yingzi Cong and Casey T. Weaver -- The B-cell system in inflammatory bowel disease / Per Brandtzaeg, Hege S. Carlsen and Trond S. Halstensen -- Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases / Claudio Fiocchi ... [et al.] -- Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease / Stephan C. Bischoff and Thomas Gebhardt -- Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease / Jonathan Braun and Stephan R. Targan -- The role of probiotics and antibiotics in regulating mucosal inflammation / Rainer Duchmann -- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease / Martin H. Holtmann and Markus F. Neurath.
    Also available: Print – 2006
  • 2014 Springer
    Pleyer, Uwe.
    These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
  • 2007 Springer
    Zhang, Jingwu.
  • 2006 ScienceDirect
    Mak, Tak W.; Saunders, Mary E.
  • 2007 Karger
    Also available: Print – 2007
  • 2015 Springer
    Ekdahl, Kristina N.; Lambris, J. D.; Nilsson, Bo; Ricklin, Daniel.
    1. Thromboinflammation in therapeutic medicine -- 2. Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions -- 3. Role of complement on broken surfaces after trauma -- 4. Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches -- 5. The lectin pathway of complement and biocompatibility -- 6. Foreign body reaction to subcutaneous implants -- 7. Molecular characterization of macrophage-biomaterial interactions -- 8. Heparan sulfate proteoglycan metabolism and the fate of grafted tissues -- 9. Xenotransplantation of cells, tissues, organs and the Greman research foundation Transregio Collaborative Research Centre 127 -- 10. Macroencapsulated pig islets correct induced diabetes in primates up to 6 months -- 11. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: points for therapeutic interventions -- 12. Cell surface engineering for reguation of immune reactions in cell therapy -- 13. Complement interception across humoral incompatibility in solid organ transplantation: a clinical perspective -- Index.
    Also available: Print – 2015
  • 2008 Springer
    Graca, Luis.
    Also available: Print – 2008
  • 2011 CRCnetBASE
    Alexander, Michael A.
    Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
  • 2007 Springer
    Shurin, Michael R.; Smolkin, Yuri S.
    Also available: Print – 2007
  • 2009. Karger
    Pourmand, Rahman.
    Acute neuropathies / Bromberg, M.B. -- Chronic neuropathies : chronic inflammatory demyelinating neuropathy and its variants / Ramchandren, S., Lewis, R.A. -- Nonsystemic vasculitic neuropathy : update on diagnosis, classification, pathogenesis, and treatment / Collins, M.P., Periquet-Collins, I. -- Dysimmune neuropathy / Kwan, J.Y. -- Autoimmune autonomic ganglionopathy / Winston, N., Vernino, S. -- Myasthenia gravis with anti-acetylcholine receptor antibodies / Meriggioli, M.N. -- Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis / Muppidi, S., Wolfe, G.I. -- Lambert-Eaton myasthenic syndrome / Pourmand, R. -- Idiopathic inflammatory myopathies / Dimachkie, M.M., Barohn, R.J. -- Stiff person syndrome / Duddy, M.E., Baker, M.R.
  • 2008 Springer
    Vajdy, Michael.
  • 2013 Cold Spring Harb Lab Press
    O'Garra, Anne.
    Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.
  • 2013 Springer
    Malyshev, Igor.
    A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
  • 2002 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2002 NAP
    McCormick, Marie C.; Stratton, Kathleen R.; Wilson, Christopher B.
  • 2003 NAP
    Almario, Donna A.; McCormick, Marie C.; Stratton, Kathleen R.; Wizemann, Theresa.
  • 2013 Springer
    Selvarajoo, Kumar.
    Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.
  • 2007 CRCnetBASE
    Van Emon, Jeanette M.
    Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
  • 2006 Springer
    Colonna, M.; Vivier, E.
    Also available: Print – 2006
  • 1978-
    Atassi, M. Z.; Stavitsky, Abram Benjamin.
  • 2010 Springer
    Burry, Richard W.
  • 2015 Springer Protocols
    Lossi, Laura; Merighi, Adalberto.
    Machine generated contents note: 1.The Evolution of Immunocytochemistry in the Dissection of Neural Complexity / Laura Lossi -- pt. I Immunocytochemistry in Non-Mammalian Brain -- 2.Immunofluorescence and Genetic Fluorescent Labeling Techniques in the Drosophila Nervous System / Christian Wegener -- 3.Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris / Graziano Fiorito -- 4.Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish Brain / Yoshihiro Yoshihara -- pt. II Detection of Cell Proliferation and Neurogenesis -- 5.Immunocytochemical Phenotype of Differentiating Neurons / Antonio Carai -- 6.Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus / Oliver von Bohlen und Halbach -- 7.Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations / Pasko Rakic --
  • 2006 Springer
    Brassat, David; Oksenberg, Jorge R.
    HLA and autoimmunity : structural basis of immune recognition / Kai W. Wucherpfennig -- Genomic variation and autoimmune disease / Silke Schmidt and Lisa F. Barcellos -- Endocrine diseases : type I diabetes mellitus / Regine Bergholdt, Michael F. McDermott, and Flemming Pociot -- Endocrine diseases : Graves' and Hashimoto's diseases / Yoshiyuki Ban and Yaron Tomer -- Central and peripheral nervous system diseases / Dorothée Chabas, Isabelle Cournu-Rebeix, and Bertrand Fontaine -- Immunogenetics of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus / Allison Porter and J. Lee Nelson -- Gastroenterologic and hepatic diseases / Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux -- Inflammatory myopathies : dermatomyositis, polymyositis, and inclusion body myositis / Renato Mantegazza and Pia Bernasconi -- Hematologic diseases : autoimmune hemolytic anemia and immune thrombocytopenic purpura / Mattias Olsson ... [et al.] -- Genetics of autoimmune myocarditis / Mehmet L. Guler, Davinna Ligons, and Noel R. Rose.
  • 2008 Springer
    Møller, Eva Horn; Weert, Marco van de.
  • 2008 Springer
    Brusic, Vladimir; Ranganathan, Shoba; Schönbach, Christian.
    IMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
  • 2007 Springer Protocols
    Flower, Darren R.
  • 2011 Springer
    Marincola, Francesco M.; Wang, Ena.
    pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection.
  • 2010 Springer
    Batista, Facundo; Saito, Takashi.
    Insights into function of the immunological synapse from studies with supported planar bilayers / M.L. Dustin -- Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions / J. Doh and M.F. Krummel -- Molecular and cellular dynamics at the early stages of antigen encounter: the B-cell immunological synapse / Y.R. Carrasco -- Inhibitory and regulatory immune synapses / P. Eissmann and D.M. Davis -- The immunological synapse, TCR microclusters, and T cell activation / T. Yokosuka and T. Saito -- Signaling amplification at the immunological synapse / A. Viola, R.L. Contento and B. Molon -- Multiple microclusters: diverse compartments within the immune synapse / S.C. Bunnell -- A conformation-induced oligomerization model for B cell receptor microclustering and signaling / P. Tolar and S.K. Pierce -- Co-receptors and recognition of self at the immunological synapse / N.R. Gascoigne ... [et al.] -- Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses / A. Alcover and M.I. Thoulouze -- Plasticity of immunological synapses / S. Valitutti and L. Dupre -- APC, T cells, and the immune synapse / P. Reichardt, B. Dornbach and M. Gunzer.
    Also available: Print – yyyy
  • 2007 Springer Protocols
    Fairchild, Paul J.
  • 2002 NCBI Bookshelf
    Frank, Steven A.
  • 2005 Springer
    Langhorne, J.
    The dissection of CD8 T cells during liver-stage infection / U. Krzych and R.J. Schwenk -- Early interactions between blood-stage Plasmodium parasites and the immune system / B.C. Urban, R. Ing, and M.M. Stevenson -- Longevity of the immune response and memory to blood-stage malaria infection / A.H. Achtman ... [et al.] -- Experimental models of cerebral malaria / C. Engwerda ... [et al.] -- Glycosylphosphatidylinositols in malaria pathogenesis and immunity : potential for therapeutic inhibition and vaccination / C.S. Boutlis ... [et al.] -- The immunology and pathogenesis of malaria during pregnancy / J.G. Beeson and P.E. Duffy.
    Also available: Print – 2005
  • 2015 Springer
    Müller, N.; Myint, Aye-Mu; Schwarz, Markus J.
    Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
  • 2009
    Turgeon, Mary Louise.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 ScienceDirect
    Flaherty, Dennis K.
    With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
  • 2014 Springer
    Massoud, Ahmad; Rezaei, Nima.
    An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
  • 2007 Springer
    Brown, Gordon D.; Netea, Mihai G.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2010 ScienceDirect
    Kabelitz, Dieter; Kaufmann, S. H. E.
    1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
  • 2005 Karger
    Markert, Udo R.
    Also available: Print – 2005
  • 2006 Springer
    Mor, Gil.
    Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] -- Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov -- Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
  • 2014 Springer
    Weissenbacher, E. R.
    Fundamentals of immunology: Concepts of innate and specific immunity -- Mucosal immunology -- General immunology of the genital tract: Distinct features of the genital mucosal tissue -- Functions and regulation of innate immune responses in the human reproductive tract -- Functions and regulation of adaptive humoral and cell-mediated immunity in the female genital tract -- Immunization studies -- Immunology of menstruation {u2013} menstruation as an inflammatory process -- Immunology of genital tract infections: Viral infections of the genital tract -- Bacterial infections of the genital tract -- Candidiasis -- Trichomoniasis -- Immunology in reproductive medicine: Immunology of pregnancy -- Immunologic infertility -- Immunocontraceptive approaches.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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