Books by Subject
- Adenosine receptors : therapeutic aspects for inflammatory and immune diseases — Developmental biology of peripheral lymphoid organs (158)
- Developments in hematology and immunology — Immunology of pregnancy (158)
- Immunology of the female genital tract — Neuroinflammation-- new insights into beneficial and detrimental functions (158)
- Neuroinflammation and CNS disorders — Wiley-Blackwell handbook of psychoneuroimmunology (156)
Allergy and Immunology
- v. 39, 2005. SpringerAlso available: Print – v. 2, 5, 10-11, 17, 29, 1982, 1984-85, 1987, 1994.
- 2015 SpringerPaolo A. Ascierto, David F. Stroncek, Ena Wang, editors.1. New insight of peptide vaccination in cancer immunotherapy -- 2. The determinants of T cell function for effective anticancer vaccine -- 3. T cell fate in the tumor microenvironment -- 4. T cell receptor avidity and affinity and tumor specific TCR engineer -- 5. Host genetic variation and somatic alteration associated with favorable or compromised T cell function -- 6. Production of Clinical T Cell Therapies -- 7. Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes.-8. Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer -- 9. T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy -- 10. T cell modulation- anti-OD-1 antibodies for the treatment of cancer -- 11. T cell based therapies in combination with other procedures -- 12. Chimeric antigen receptor T cells CD19 CAR -- 13. Hematopoietic Stem Cell transplantation as immune therapy of malignancies.
- 2014 Wileyedited by Alberto Signore, MD, PhD, Professor of Nuclear Medicine, Nuclear Medicine Unit, Department of Medical-Surgical Sciences and of Translational Medicine and Psychology, "Sapienza" University, Rome, Italy, Ana Maria Quintero, MD, Radiologist, Department of Radiology, Clinica Reina Sofia, Clinica Colsanitas, Bogotá, Colombia.Epidemiology of infections in the new century / Nicola Petrosillo -- Bacterial osteomyelitis : the clinician point of view / Ilker Uçkay, Nicolas Christian Buchs, Khalid Seghrouchni, Mathieu Assal, Pierre Hoffmeyer, and Daniel Lew -- Radiologic imaging of osteomyelitis / Jenny T. Bencardino, Zoraida Restrepo-Velez, Randall Bujan, and Diego Jaramillo -- Radiological evaluation of spine infection / Ana Marøa Quintero and Roy Riascos -- Radiological imaging of soft tissue infections / Carolina Whittle and Giancarlo Schiappacasse -- Radiological imaging of abdominal infection and inflammatory disease / Carolina Whittle, Giancarlo Schiappacasse, and Francesca Maccioni -- Radiological imaging of vascular graft infection / Alejandro Romero, Tobøas Zander, Jorge Lopera, Sergi Quiroga, Manuel Maynar -- Radiological imaging of TB and HIV / Jorge Carrillo -- Nuclear medicine imaging of infections : techniques, acquisition protocol, and interpretation criteria / Alberto Signore -- Nuclear medicine imaging of osteomyelitis : WBC, monoclonal antibody, or bacterial imaging? / Christopher J. Palestro -- Nuclear medicine imaging of spondylodiscitis : the emerging role of PET / Elena Lazzeri, Paola Anna Erba, Martina Sollini, Giuliano Mariani -- Nuclear medicine imaging of soft tissue infections / Bárbara Roxana Morales Klinkert -- Nuclear medicine imaging of infections and inflammatory diseases of the abdomen / Josep Martøn Comøn, Alba Rodrøguez Gasén, and Christophe Van de Wiele -- Nuclear medicine imaging of vascular graft infections : the added role of hybrid imaging / Ora Israel -- Nuclear medicine imaging of TB and HIV / Mike Sathekge, Christophe van de Wiele, and Alberto Signore -- Nuclear medicine imaging in fever of unknown origin / François-Xavier Hanin and François Jamar -- Nuclear medicine imaging of inflammatory diseases / Marco Chianelli, Gaurav Malviya, Andor W.J.M. Glaudemans, and Alberto Signore.
- 2014 ClinicalKeyDavid J. Dabbs, editor.Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at expertconsult.com, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
- 2007 SpringerJ.-P. Lepoittevin, C.J. Le Coz ; with a contribution by Peter J. Frosch.Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.
- 2010 Springeredited by Ronald R. Watson, Sherma Zibadi, Victor R. Preedy.
- Diseases of the sinuses : a comprehensive textbook of diagnosis and treatment. Second edition [2nd ed.]2014 SpringerC.C. Chang, G.A. Incaudo, M.E. Gershwin, editors.Diseases of the Sinuses: A Comprehensive Textbook of Diagnosis and Treatment, 2nd Edition, offers the definitive source of information about the basic science of the sinuses and the clinical approach to sinusitis. Since the widely praised publication of the first edition, understanding of sinus disease has changed dramatically, mainly as a result of recent developments and new discoveries in the field of immunology. This updated and expanded edition is divided into sections addressing, separately, the pathogenesis, clinical presentation, medical and surgical management of acute and chronic rhinosinusitis. Special entities such as autoimmune-related sinusitis, allergy and sinusitis, and aspirin-exacerbated respiratory disease are discussed in separate chapters. The role of immunodeficiency is also addressed. The management section has been fully updated to incorporate new medical modalities and surgical procedures. Developed by a distinguished group of international experts who share their expertise and insights from years of collective experience in treating sinus diseases, the book will appeal to anyone who has an interest in sinus disease, including both physicians and allied health professionals. Internists, pediatricians, allergists, otolaryngologists and infectious disease specialists will find the book to be an invaluable, comprehensive reference. Physician assistants and nurse practitioners who work with specialists who treat sinus disease will also benefit from the book.
- 2011Kaitian Peng.Francisella is a gram-negative bacterium that causes tularemia. It is capable of infecting a remarkably broad host range including humans, mammals, birds and fish via multiple different routes of infection, establishing a successful colonization event within the various organs. This facultative, intracellular pathogen is also capable of invading a broad range of host cell types ranging from macrophages to fibroblasts. This is an extremely fascinating facet of the bacterium. The ability of Francisella to infect such a wide range of hosts and cell types suggests that the bacterium either co-opts cellular mechanisms common to all hosts and cell types or has the requisite bacterial genes to adapt to many different intraorganismal environments, or both. We were interested in studying the diverse repertoire of interactions that may occur between the bacterium and its murine host. In this thesis, the transposon site hybridization (TraSH) negative selection strategy was applied in a range of in vivo and in vitro systems to identify novel host-pathogen interactions in Francisella. We subsequently demonstrated that Francisella require tryptophan for virulence specifically in the lungs due to lung-specific induction of a host innate immune molecule indoleamine 2,3-dioxygenase 1. Alveolar macrophages may also deplete intracellular trytophan via a novel mechanism and microbial lung-specific requirement of tryptophan for virulence may be widely applicable to all bacterial species. We also demonstrate that Francisella hypercytotoxic mutants, unlike previously suggested, induce macrophage hypercytotoxicity due to increased bacteriolysis in the intracellular milieu. Identification and characterization of bacterial mutants that are attenuated under different in vitro and in vivo conditions have led to further insights into the interactions that occur between Francisella and its murine host.
- 2014 Springer Protocolsedited by Monica Rinaldi, Daniela Fioretti, Sandra Iurescia.Blueprint for DNA vaccine design / Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of plasmid-mediated transgene expression / Daniela Fioretti, Sandra Iurescia, and Monica Rinaldi -- Strategies for improving DNA vaccine performance/ Sandra Iurescia, Daniela Fioretti, and Monica Rinaldi -- Enhancement of DNA vaccine efficacy by intracellular targeting strategies / Elisabete Borges Freitas ... [et al.] -- Progresses in DNA-based heterologous prime-boost immunization strategies / Ronald J. Jackson, David B. Boyle, and Charani Ranasinghe -- Development of antibiotic-free selection system for safer DNA vaccination / Jeremy M. Luke, Aaron E. Carnes, and James A. Williams -- Electroporation-based DNA delivery technology : methods for gene electrotransfer to skin / Anita Gothelf and Julie Gehl -- DNA vaccination in skin enhanced by electroporation / Kate E. Broderick, Amir S. Khan, and Niranjan Y. Sardesai -- Intradermal vaccination by DNA tattooing / Joost H. van den Berg ... [et al.] -- Microneedle applications for DNA vaccine delivery to the skin / Hae-yong Seok ... [et al.] -- Multivalent DNA-based vectors for DNA vaccine delivery / Young Hoon Roh ... [et al.] -- Superparamagnetic nanoparticle delivery of DNA vaccine / Fatin Nawwab Al-Deen ... [et al.] -- Plasmid fermentation process for DNA immunization applications / Aaron E. Carnes and James A. Williams -- Pharmaceutical grade large-scale plasmid DNA manufacturing process / Marco Schmeer and Martin Schleef -- Protective and therapeutic DNA vaccination against allergic diseases / Almedina Isakovic ... [et al.] -- Immunotherapy for Alzheimer's disease : DNA- and protein-based epitope vaccines / Hayk Davtyan, Irina Petrushina, and Anahit Ghochikyan -- Tetravalent DNA vaccine product as a vaccine candidate against Dengue / Kevin R. Porter, Nimfa Teneza-Mora, and Kanakatte Raviprakash -- DNA vaccination as a treatment for chronic kidney disease / Yuan Min Wang and Stephen I. Alexander.
- 2013 SpringerBrian A. Baldo, Nghia H Pham.Adverse reactions to drugs and drug allergy: scope of this book --Classification and descriptions of allergic reactions to drugs -- Mechanisms of hypersensitivity -- Diagnosis of allergic reactions to drugs -- β-lacam antibiotics -- Other antimicrobial drugs -- Drugs and other agents used in anesthesia and surgery -- Opiod analgesic drugs -- Nonsteroidal anti-inflammatory drugs -- Contrast media -- Biologics -- Corticosteroids -- Drugs used for chemotherapy -- Proton pump inhibitors -- Postface-concluding remarks.
- 2014 SpringerXavier Bosch, Manuel Ramos-Casals, Munther A. Khamashta, editors.
- 2009 SpringerMatthew J. Colloff."The purpose of Dust Mites is to provide a comprehensive reference work for all readers with an involvement or interest in house dust mite research and management, incorporating ... the topics of systematics and identification, physiology, ecology, allergen biochemistry and molecular biology, epidemiology, mite control and allergen avoidance."--From publisher's notes.
- 2010Jeff Dennis Campbell.T cells will usually recognize any pathogen that threatens the body, despite the many different and constantly changing forms these pathogens can take. This is accomplished by the enormous diversity of T-cell receptors that are randomly generated during T-cell maturation. There are a number of distinct mechanisms that drive this diversity: one is the recombination of gene segments, (designated V, D, and J), from pools of many possible gene segments. Another is the addition and deletion of nucleotides at the gene segments joints (between the V, D, and J segments). This yields ~10^15 different possible T-cell receptors, which is many times greater that the number of T cells in the periphery of either mice (~10^8) or humans (~10^11). The T-cell receptor is formed from two polypeptide chains, α and β, each derived from separately rearranged gene segments. Each chain is composed of semi-randomly chosen gene segments. We utilized three transgenes, one limiting the α chain and two limiting the β chain. These progressively limited the number available gene segments of 100 Vα's to 1; 50 Jα's to 2; 30 Vβ's to 1; 2Dβ's to 1 and 13 Jβ's to 2. This reduced the number of gene segment combinations from a theoretical 3,900,000 to 4 combinations. The addition and deletion of nucleotides at the gene segment joints is unaffected. In an in vivo CTL killing assay, the mice with these limited T cell repertoires are able to recognize most but not all of the antigenic peptides tested (9 of 11, in the most restricted mice). Their immunity to Listeria monocytogenes was reduced somewhat; but the LD50 of Yersinia pseudotuberculosis was not diminished by limiting T-cell repertoire, and viral load after murine cytomegalovirus infection was similar to wild type. The limited repertoire mice also exhibited less vigorous alloreactive responses to some haplotypes, indicating that alloreactive responses are influenced by V gene segment compatibility with the MHC. We conclude that N and P nucleotide addition is sufficient for the bulk of T-cell immunity, at least in the laboratory setting. Limiting V(D)J gene segment choice, despite eliminating some T-cell specificities, does not have a dramatic effect on T-cell immunity.
- 2010Eric Mabery.Eiger is the sole TNF family member found in Drosophila melanogaster. This signaling molecule is induced during infection and is required for an appropriate immune response to many microbes; however, little is known concerning where eiger is produced and what genes are regulated by eiger. Here we show that eiger is made in the fly's fat body during a Salmonella typhimurium infection. Using tissue specific knockdowns we found that eiger expression in the fat body is required for all of the phenotypes we observed in eiger null mutant flies. This includes reduced melanization, altered antimicrobial peptide expression and reduced feeding rates. The effect of eiger on feeding rates alone may account for the entire phenotype seen in eiger mutants infected with S. typhimurium. We further characterized the eiger response using transcriptional arrays. We found that the eiger regulates a number of genes involved in metabolism and hormonal signaling during an immune response. How these genes are involved in the immune response is not clear. Finally we examined the role of age related decline of the immune system in D. melanogaster during bacterial infection. We found that vigor and tolerance are reduced when old flies are challenged with a variety of bacterial pathogens.
- 2015 Springer Protocolsedited by Robert Hnasko.
- 2009 Springer Protocolsby John R. Crowther.
- 2012 ClinicalKeyJeffrey K. Actor.This concise, high-yield title in the popular Integrated Review Series focuses on the core knowledge in immunology and microbiology while linking that information to related concepts from other basic science disciplines. Case-based questions at the end of each chapter enable you to gauge your mastery of the material, and a color-coded format allows you to quickly find the specific guidance you need. This concise and user-friendly reference provides crucial guidance for the early years of medical training and USMLE preparation. Effectively review for problem-based courses with the help of text boxes that help you clearly see the clinical relevance of the material.
- Elucidating Toxoplasma gondii's engagement with the host : identification of dense granule protein 25 (GRA25), a novel member of the parasite's arsenal and characterization of strain-specific differences in the modulation of host immune responses2013Anjali Joshi Shastri.The ubiquitous parasite Toxoplasma gondii has developed an exquisite arsenal of effectors to support its intracellular lifestyle and its persistence within its diverse hosts. In order to survive and resist clearance, this obligate intracellular parasite must contend with the host immune response. Different strains of the parasite vary dramatically in their interaction with the immune system, and studying these strain differences has furthered our understanding of the spectrum of host-pathogen interactions and led to the identification of parasite effectors. The work described here dissects the interactions between different strains of the parasite and host macrophages: innate immune cells that paradoxically both serve as a niche for parasite replication and defend the host against parasite infection. Chapter 1 introduces Toxoplasma, the immune response to infection, and discusses the role of known parasite effectors. Experiments described in Chapter 2 identify a novel secreted parasite factor, GRA25, which modulates cytokine secretion in macrophages and controls parasite virulence in mice. In Chapter 3, high throughput methods are used to characterize the transcriptional and phosphorylation landscape of macrophages infected with different Toxoplasma strains. These analyses demonstrate that a secreted polymorphic tyrosine kinase, ROP16, directs murine macrophage polarization towards an alternatively activated phenotype. They also reveal that Toxoplasma parasites activate the Type I interferon response, a response classically associated with cytosolic pathogens. Chapter 4 describes work demonstrating that Toxoplasma strain-specifically modulates the innate immune response via secretion of a parasite factor, MAF1, which recruits host mitochondria to the parasitophorous vacuole. Finally, Chapter 5 discusses the future directions and implications of this work in the broader context of host-pathogen interactions.
- Emerging immunosuppressants : the identification, characterization and in vivo application of Orai channel inhibitors2012A. Masoud Sadaghiani.Store-operated calcium (SOC) entry and channel play a central role in regulating intracellular calcium concentrations in a variety of cell types. SOC is critical for many physiological processes, most notably activation of the immune system, where its lack of function is known to cause severe combined immunodeficiency (SCID) in human patients. In lymphocytes, where SOC has been extensively studied, it has been shown that SOC is mediated by the calcium channel Orai that is activated by its direct binding to STIM, a calcium sensor localized in the endoplasmic reticulum. While it was previously thought that SOC serves an important role only in immune and non-excitable cells, it is now clear that SOC and the proteins that regulate its function are ubiquitously expressed in variety of tissues, including muscle and the nervous system, and serve a diverse set of biological functions. More recently, SOC has been shown to act in a several pathological processes, ranging from muscular dystrophy to cancer, underscoring the significance of gaining a better understanding of its mechanism of action. Here we set out to develop pharmacological blockers of SOC, in order to gain insights into its molecular mechanism and physiological role. Such blockers could allow for acute inhibition of SOC, allowing for a temporal control that is essential for mechanistic studies. If successfully developed, such reagents could also be of therapeutic use as immunosuppressants or anti thrombotic agents in human patients. We designed a novel methodology for generating SOC blockers based on the identification and targeting of minimal functional domains (MFDs) of STIM and Orai. Using this approach, we identified small molecule blockers that can inhibit SOC at high nanomolar concentrations and can also block T cell activation in vitro and in vivo. These studies not only provide an important set of tools for better understanding STIM and Orai function, but also identify compounds that could potentially be developed into therapeutic agents for the treatment of pathological conditions such as autoimmune disease.
- 2012 Future Mededitors, Steven G. Reed, Christopher B. Fox, Darrick Carter.Emulsion-based vaccine adjuvants / Christopher Fox, Darrick Carter & Steven G. Reed -- MF59® : an oil-in-water adjuvant / Jennifer Whitaker, Nadine Rouphael & Mark J. Mulligan -- AS03 adjuvant / Woolf T. Walker & Saul N. Faust -- Innovations in emulsion technology / Christopher B. Fox, Darrick Carter, Susan L. Baldwin, & Steven G. Reed -- Index.
- 2014 SpringerIan R Mackay, Noel R Rose, editors-in-chief ; Dennis K Ledford, Richard F. Lockey editors.
- 2014 SpringerIan MacKay, Noel R. Rose, editors-in-chief ; Betty Diamond, Anne Davidson, editors.
- 2005 SpringerHans-Werner Vohr (ed.).
- 2013John Rhodes."At the turn of the twentieth century, smallpox claimed the lives of two million people per year. By 1979, the disease had been eradicated and victory was declared across the globe. Yet the story of smallpox remains the exception, as today a host of deadly contagions, from polio to AIDS, continue to threaten human health around the world. Spanning three centuries, The End of Plagues weaves together the discovery of vaccination, the birth and growth of immunology, and the fight to eradicate the world's most feared diseases. From Edward Jenner's discovery of vaccination in 1796, to the early nineteenth-century foundling voyages in which chains of orphans, vaccinated one by one, were sent to colonies around the globe, to the development of polio vaccines and the stockpiling of smallpox as a biological weapon in the Cold War, world-renown immunologist John Rhodes charts our fight against these plagues, and shows how vaccinations gave humanity the upper hand. Today, aid groups including the Bill and Melinda Gates Foundation and the World Health Organization have made the eradication of polio a priority, and Rhodes takes us behind the scenes to witness the hard-fought battles of scientist, philanthropists, volunteers, and more, and how soon we may be celebrating the eradication of a second infectious disease, polio"--Provided by publisher.
- 2008 ScienceDirectedited by Sara E. Walker and Luis J. Jara.This book is one of the first to evaluate the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements and focuses on the importance of steroidal hormones in the pathogenesis and therapeutical management of the autoimmune rheumatic diseases. In particular, the chapters analyze the mechanisms of action and the involvement of adrenal steroids (glucocorticoids) in the neuroendocrine immune system, including the effects on elderly. The perturbations of the HPA axis as source of altered steroidal sythesis will be discussed and related to some interesting pathological conditions often complicating the autoimmune rheumatic diseases susch as psychosis or fibromyalgia. Concerning the role of gonadal steroids (sex hormones), several chapters will discuss clinical and epidemiological evidences of their role, as well as their effects as risk factors in autoimmune rheumatic diseases, including a section in Pediatrics. *The premier issue evaluating the role of Steroids in autoimmune rheumatic diseases from the basic mechanisms to the clinical involvements *Documents the latest research and indicate recent and coming new therapeutical-biological approaches to the therapy *The book will present therapeutical perspectives concerning the new glucocorticoids, and the effects of biological drugs on their synthesis.
- 2015 SpringerFriedrich Koch-Nolte, editor.Part I. Evolution and detection of endogenous ADP-ribosylation. The natural history of ADP-ribosyltransferases and the ADP-ribosylation system / L. Aravind, Dapeng Zhang, Robson F. de Souza, Swadha Anand and Lakshminarayan M. Iyer -- Identification and analysis of ADP-ribosylated proteins / Friedrich Haag and Friedrich Buck -- Part II. ADP-ribosylation by ARTCs (R-S-E ARTs). Photorhabdus luminescens Toxins TccC3 and TccC5: insecticidal ADP-ribosyltransferases that modify threonine and glutamine / Klaus Aktories, Gudula Schmidt and Alexander E. Lang -- Reaction mechanism of mno-ADP-ribosyltransferase based on structures of the complex of enzyme and substrate protein / Hideaki Tsuge and Toshiharu Tsurumura -- Regulation of nitrogenase by reversible mono-ADP-ribosylation / Vivian R. Moure, Flavia F. Costa, Leonardo M. Cruz, Fabio O. Pedrosa, Emanuel M. Souza, Xiao-Dan Li, Fritz Winkler and Luciano F. Huergo -- ADP-ribosylation of P2X7: a matter of life and death for regulatory T cells and natural killer T cells / Björn Rissiek, Friedrich Haag, Olivier Boyer, Friedrich Koch-Nolte and Sahil Adriouch -- Pierisins and CARP-1: ADP-ribosylation of DNA by ARTCs in butterflies and shellfish / Tsuyoshi Nakano, Azusa Takahashi-Nakaguchi, Masafumi Yamamoto and Masahiko Watanabe -- Part III. ADP-ribosylation by ARTDs (H-Y-E ARTs). Comparative structural analysis of the putative mono-ADP-ribosyltransferases of the ARTD/PARP family / Ana Filipa Pinto and Herwig Schüler -- Function and regulation of the mono-ADP-ribosyltransferase ARTD10 / Max Kaufmann, Karla L.H. Feijs and Bernhard Lüscher -- Regulation of nucleocytoplasmic transport by ADP-tibosylation: the emerging role of Karyopherin-[Beta]1 mono-ADP-ribosylation by ARTD15 / Maria Di Girolamo -- Index.
- 2010 SpringerShauna M. Dauphinee, Aly Karsan, editors.
- 2010 SpringerXiaoyuan Wang, Peter J. Quinn, editors.Endotoxins: Lipopolysaccharides of Gram-negative bacteria / X. Wang and P.J. Quinn -- Purification and characterization of lipopolysaccharides / X. Wang ... [et al.] -- Endotoxins: Relationship between structure, function, and activity / K. Brandenburg, A.B. Schromm and T. Gutsmann -- The diversity of the core oligosaccharide in lipopolysaccharides / A. Silipo and A. Molinaro -- Salmonella-regulated lipopolysaccharide modifications / S.M. Richards, K.L. Strandberg and J.S. Gunn -- The variation of O antigens in Gram-negative bacteria / L. Wang, Q. Wang and P.R. Reeves -- Regulators of TLR4 signaling by endotoxins / A.F. McGettrick and L.A.J. O'Neill -- Membrane partitioning: Is location everything when it comes to endotoxin recognition? / M. Triantafilou and K. Triantafilou -- Endotoxin detection - from limulus amebocyte lysate to recombinant Factor C / J.L. Ding and B. Ho -- The role of endotoxin in infection: Helicobacter pylori and Campylobacter jejuni / A.P. Moran -- The role of pseudomonas lipopolysaccharide in cystic fibrosis airway infection / S.M. Moskowitz and R.K. Ernst -- Development of small-molecule endotoxin sequestering agents / S.A. David and D. Sil -- Development of an anti-endotoxin vaccine for sepsis / A.S. Cross -- Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants / C.B. Fox ... [et al.] -- Targeting endotoxin in the treatment of sepsis / J.-S. Rachoin, C.A. Schorr and R.P. Dellinger -- Lipopolysaccharides in rhizobium-legume symbioses / R.W. Carlson, L.S. Forsberg and E.L. Kannenberg -- Lipopolysaccharides and plant innate immunity / G. Erbs ... [et al.].
- 2013David Halladin.This thesis examines three topics that are related to the Gram-positive bacterial cell envelope. First, I examine how transmembrane proteins navigate through the thick, heavily cross-linked Gram-positive cell wall while remaining anchored to the bacterial membrane. I develop a theoretical model that predicts that entropic confinement of a disordered protein can drive translocation through the cell wall. I experimentally test important predictions of the model to demonstrate that translocation depends on the length of the translocating protein and the geometry of the bacterial surface, while demonstrating that entropy-driven translocation occurs in a variety of Gram-positive species. Second, I study how the antimicrobial peptide nisin causes cell death in Gram-positive bacteria. I demonstrate that nisin treatment triggers membrane collapse in multiple Gram-positive species, and provide evidence that collapse is initiated by an increase in compressive stress in the membrane. Finally, I examine the process of cell division in the Gram-positive coccus Staphylococcus aureus. Contrary to the current view of S. aureus division, cell volume increases monotonically during the cell cycle, as opposed to occurring entirely during cell separation. I observed a dramatic millisecond hemisphere-to-sphere transition during cell separation that was accompanied by a decrease in surface area, suggesting that separation is associated with a redistribution of cell wall stress.
- 2014 Springer Protocolsedited by Garry M. Walsh.
- 2013 SpringerMarién Pascual, Sergio Roa.Introduction -- Immune System and Atopic Disorders -- Epigenetics -- Epigenetics, Environment, and Allergic Diseases -- Conclusions and Future Perspectives.
- 2011 Springeredited by Esteban Ballestar.An introduction to epigenetics / Esteban Ballestar -- Chromatin mechanisms regulating gene expression in health and disease / Constanze Bonifer and Peter N. Cockerill -- Epigenetic control of lymphocyte differentiation / Eduardo Lopez-Granados -- Epigenetic control in immune function / Peter J. van den Elsen, Marja C.J.A. van Eggermond, and Rutger J. Wierda -- DNA methylation and B-cell autoreactivity / Soizic Garaud, Pierre Youinou, and Yves Renaudineau -- Environmental agents and autoimmune diseases / Frederick W. Miller -- Epigenetic dysregulation of Epstein-Barr virus latency and development of autoimmune disease / Hans Helmut Niller ... [et al.] -- Does genomic imprinting play a role in autoimmunity? / Cristina Camprubø and David Monk -- A new epigenetic challenge : systemic lupus erythematosus / Biola M. Javierre and Bruce C. Richardson -- Epigenetic deregulation in rheumatoid arthritis / Emmanuel Karouzakis ... [et al.] -- Prospects for epigenetic compounds in the treatment of autoimmune disease / Nadine Chapman-Rothe and Robert Brown -- Profiling epigenetic alterations in disease / Josø Ignacio Martøn-Subero and Manel Esteller.
- 2012 SpringerCornelis Murre, editor.Previous observations, generated by many in the field, have provided a first glimpse into the epigenetic mechanisms that underpin lymphocyte and myeloid development. We are only now beginning to merge the multitude of observations into a common framework. At the same time it has become more difficult for the individual mind to comprehend more than a tiny focused fraction of it. The studies described in this volume serve as a starting point to familiarize one self with the multifarious differences in epigenetic designs that orchestrate the progression of developing blood cells. They also may serve as a general paradigm for the mechanisms that underpin the control of eukaryotic gene expression.
- 2009 Springer Protocolsedited by Ulrich Reineke and Mike Schutkowski.What is a B-cell epitope? / Marc H.V. Van Regenmortel -- Structural basis of antibody-antigen interactions / Eric J. Sundberg -- Epitope mapping of antibody-antigen complexes by nuclear magnetic resonance spectroscopy / Osnat Rosen and Jacob Anglister -- A solid-phase mutual inhibition assay with labeled antigen / Masahide Kuroki -- Epitope mapping by surface plasmon resonance / Pär Säfsten -- Proteolytic fragmentation for epitope mapping / Maria R. Mazzoni, Francesca Porchia, and Heidi E. Hamm -- Epitope mapping by proteolysis of antigen-antibody complexes / Suraj Dhungana ... [et al.] -- Identifying residues in antigenic determinants by chemical modification / Howard M. Reisner and Roger L. Lundblad -- Epitope mapping by differential chemical modification of antigens / Suraj Dhungana, Michael B. Fessler, and Kenneth B. Tomer -- Linear B-cell epitope mapping using enzyme-linked immunosorbent assay for libraries of overlapping synthetic peptides / Michael W. Heuzenroeder ... [et al.] -- Antibody epitope mapping using SPOT peptide arrays / Ulrich Reineke and Robert Sabat -- Peptide microarrays for profiling of modification state-specific antibodies / Johannes Zerweck, Antonia Masch, and Mike Schutkowski -- Epitope mapping using phage display peptide libraries / Volker Böttger and Angelika Böttger -- Antibody epitope mapping using de novo generated synthetic peptide libraries / Ulrich Reineke -- Antibody specificity profiling on functional protein microarrays / Dawn R. Mattoon and Barry Schweitzer -- Peptide microarrays for determination of cross-reactivity / Alexandra Thiele -- Epitope mapping using randomly generated peptide libraries / Juliane Bongartz, Nicole Bruni, and Michal Or-Guil -- Probing the epitope signatures of IgG antibodies in human serum from patients with autoimmune disease / Peter Lorenz ... [et al.] -- Microarrayed allergen molecules for diagnostics of allergy / Jing Lin, Ludmilla Bardina, and Wayne G. Shreffler -- Monitoring B cell response to immunoselected phage-displayed peptides by microarrays / Lina Cekaite, Eiving Hovig, and Mouldy Sioud -- Epitope mapping using homolog-scanning mutagenesis / Lin-Fa Wang -- Epitope mapping by region-specified PCR-mutagenesis / Tsutomu Mikawa, Masayuki Ikeda, and Takehiko Shibata -- Epitope mapping using phage-display random fragment libraries / Lin-Fa Wang and Meng Yu -- Prediction of linear B-cell epitopes / Ulf Reimer -- Molecular recognition of diverse ligands by T-cell receptors / Eric J. Sundberg -- Identification of human MHC class I binding peptides using the iTOPIA epitope discovery system / Markus Wulf, Petra Hoehn, and Peter Trinder -- T-cell epitope mapping in Mycobacterium tuberculosis using PepMixes created by micro-scale SPOT synthesis / Marisa Frieder and David M. Lewinsohn -- High-throughput T-cell epitope discovery through MHC peptide exchange / Sine Reker Hadrup ... [et al.] -- T-cell epitope processing (the epitope flanking regions matter) / Alejandra Nacarino Martinez, Stefan Tenzer, and Hansjörg Schild -- Identification of MHC class II binding peptides : microarray and soluble MHC class II molecules / Simani Gaseitsiwe and Markus J. Maeurer -- T-cell epitope mapping / Raija K.S. Ahmed and Markus J. Maeurer -- Identification and validation of T-cell epitopes using the IFN-[gamma] EliSpot assay / Markus Wulf, Petra Hoehn, and Peter Trinder.
- 2015 Springerv. 2 SpringerChristian Münz, editor.
- 11973.Roitt, Ivan M.
- Essential role of the immune system in remodeling the tumor microenvironment upon oncogene inactivation2011Kavya Rakhra.Oncogene addiction is thought to occur cell autonomously. Immune effectors are implicated in the initiation and restraint of tumorigenesis, but their role in oncogene inactivation-mediated tumor regression is unclear. Here, we show that an intact immune system, specifically CD4+ T cells, is required for the induction of cellular senescence, shutdown of angiogenesis, and chemokine expression resulting in sustained tumor regression upon inactivation of the MYC or BCR-ABL oncogenes in mouse models of T cell acute lymphoblastic lymphoma and pro-B cell leukemia, respectively. Moreover, immune effectors knocked out for thrombospondins failed to induce sustained tumor regression. Hence, CD4+ T cells are required for the remodeling of the tumor microenvironment through the expression of chemokines, such as thrombospondins, in order to elicit oncogene addiction.
- 2015 SpringerHerbert B. Allen.Atopic dermatitis has been called "the itch that rashes", and this book reveals what causes the "itch". It presents completely new and unique findings in eczema: sweat ducts that become occluded with staphylococcal biofilms trigger the innate immune system with TLR2 receptor activity and this leads to production of the "itching" and inflammation in this disease. The Etiology of Atopic Dermatitis details new concepts that bacterial biofilms occlude sweat ducts, trigger the innate immune system, and produce the lesions in atopic dermatitis. The author discusses the findings in terms of microbiology, pathology, immunology, genetics, physiology, treatment, diseases where eczema is considered a secondary component, and diseases not previously thought to be eczema, and followed by an epilogue where eczema and psoriasis are compared. Both these diseases are caused by bacteria, but neither one can be considered an infection. As such, this book is for all who take care of patients with atopic dermatitis, including dermatologists, pediatricians, family practice doctors, allergists and pathologists. It will also be interesting for those involved in research in microbiology, physiology, immunology, and genetics.
- Evolution of whole protein and peptide microarray platforms for biological discovery and personalized medicine2013Jordan Vail Price.Since the advent of microarray technology in the early 1990's, the development of highly multiplex genomics tools has greatly outpaced the field of proteomics in terms of the generation of useful platforms for basic research and clinical analysis. Yet, to deliver on the great promise of genomics tools that analyze nucleic acids, technologies that permit the analysis of protein-protein interactions on a comparable scale need to be developed. Our group and others have shown that whole-protein and peptide microarrays can provide large amounts of information about the protein interactions that underlie the human immune response in health and disease. Here we describe three novel proteomics microarray platforms and demonstrate that the arrays can be used to gain insight into the antibody-mediated immune response in a spectrum of human diseases. In the first study, we detail the generation of a protein microarray that allows the detection of antibodies that bind to the molecular communication factors of the immune system: cytokines, chemokines, growth factors, and other circulating proteins. Using these arrays, we identified novel targets of autoantibodies in systemic lupus erythematosus, which may delineate a unique subgroup of patients within the spectrum of lupus. In the second study, we describe influenza antigen microarrays that permitted the identification of antibody reactivity to specific influenza hemagglutinin epitopes associated with poor or effective response to the seasonal influenza vaccine. These arrays have potential for development into a clinical diagnostic tool capable of predicting an individual's ability to mount an effective antibody response to vaccination. Finally, we report the development of a silicon-based peptide microarray developed in collaboration with researchers at the Intel Corporation. These "Intel arrays" hold great potential for ultimately enabling highly parallel, real-time measurement of protein-protein interaction with myriad possible downstream applications. The technologies we have developed move the field of multiplex proteomic analysis forward on many fronts, and constitute valuable additions to the proteomics toolkit available to researchers and clinicians. Moreover, our work demonstrates that detailed analysis of protein-protein interaction is required to make more informed models of different states of human health and disease.
- Examining an unexpected protective role of amyloid-beta in experimental autoimmune encephalomyelitis2012Jacqueline Leigh Grant.[Beta]-amyloid-42 (A[beta]42) and [beta]-amyloid-40 (A[beta]40), major components of senile plaque deposits in Alzheimer's disease (AD), are considered neurotoxic and pro-inflammatory. In Multiple Sclerosis (MS), A[beta]42 is upregulated in brain lesions and damaged axons. Here we found, unexpectedly, that treatment with either A[beta]42 or A[beta]40 peptides reduced motor paralysis and brain inflammation in four different models of experimental autoimmune encephalomyelitis (EAE) with attenuation of motor paralysis, reduction of inflammatory lesions in the central nervous system (CNS), and suppression of lymphocyte activation. A[beta]42 and A[beta]40 treatments were effective in reducing ongoing paralysis induced with adoptive transfer of either autoreactive Th1 or Th17 cells. High-dimensional 14-parameter flow cytometry of peripheral immune cell populations after in vivo A[beta]2 and A[beta]40 treatment revealed substantial modulations in the percentage of lymphoid and myeloid subsets during EAE. Major pro-inflammatory cytokines and chemokines were reduced in the blood following A[beta] peptide treatment. Protection conferred by A[beta] treatment did not require its delivery to the brain: adoptive transfer with lymphocytes from donors treated with A[beta]42 attenuated EAE in WT recipient mice and A[beta] deposition in the brain was not detected in treated EAE mice by immunohistochemical analysis. In contrast to the improvement in EAE with A[beta]-treatment, EAE was worse in mice with genetic deletion of the amyloid precursor protein. Therefore, in the absence of A[beta] there is exacerbated clinical EAE disease progression. Since A[beta]42 and A[beta]40 ameliorate experimental autoimmune inflammation targeting the CNS, we might now consider its potential anti-inflammatory role in other neuropathological conditions.
- 2012Cohen, Sheldon G.; Samter, Max.Antiquity -- 1190 to about 1889 -- 1890 to about 1910 -- 1911 to about 1940 -- 1941 to about 1969 -- 1970 to about 1987.
- 2015 SpringerMarco Gattorno, editor.This book, written by very well known opinion leaders in the field, covers all aspects of familial Mediterranean fever, the most common monogenic autoinflammatory disease. The opening chapters explain the genetic basis of the disease and provide insights into the pathogenesis derived from recent experimental studies. A large part of the book is then devoted to a detailed description of the typical and atypical clinical presentations, the disease course, and potential complications in both pediatric and adult patients. Guidance is provided on the measurement of disease severity and the management of patients in daily practice. The advice regarding treatment is based on the best currently available evidence and attention is also paid to important emerging treatments. The book is part of Springer's series Rare Diseases of the Immune System, which presents recently acquired knowledge on pathogenesis, diagnosis, and therapy with the aim of promoting a more holistic approach to these conditions. Monogenic autoinflammatory diseases are hereditary disorders that are caused by single-gene defects in innate immune regulatory pathways and are characterized by a clinical and biological inflammatory syndrome in which there is limited, if any, evidence of autoimmunity. Familial Mediterranean fever itself is due to a mutation in the MEFV gene, which codes for the protein pyrin; it is characterized by periodic fever and episodes of painful inflammation in the abdomen, chest, and joints. Familial Mediterranean Fever will be an invaluable source of up-to-date information for all practitioners involved in the care of patients with the disease.
- 2014 SpringerMarc Daëron, Falk Nimmerjahn, editors.This volume provides a state-of-the-art update on Fc Receptors (FcRs). It is divided into five parts. Part I, Old and New FcRs, deals with the long-sought-after Fc[micro]R and the recently discovered FCRL family and TRIM21. Part II, FcR Signaling, presents a computational model of Fc[epsilon]RI signaling, novel calcium channels, and the lipid phosphatase SHIP1. Part III, FcR Biology, addresses major physiological functions of FcRs, their glycosylation, how they induce and regulate both adaptive immune responses and inflammation, especially in vivo, FcR humanized mice, and the multifaceted properties of FcRn. Part IV, FcRs and Disease, discusses FcR polymorphism, FcRs in rheumatoid arthritis and whether their FcRs make macaques good models for studying HIV infection. In Part V, FcRs and Therapeutic Antibodies, the roles of various FcRs, including FcgRIIB and FcbRI, in the immunotherapy of cancer and autoimmune diseases using monoclonal antibodies and IVIg are highlighted. All 18 chapters were written by respected experts in their fields, offering an invaluable reference source for scientists and clinicians interested in FcRs and how to better master antibodies for therapeutic purposes.
- 2014 Springeredited by Jacob P. Thyssen, Howard Maibach.Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes. While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract. Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.
- 2016 SpringerAlexandra Adams, editors.
- 2012 ScienceDirect2012 ClinicalKey[edited by] John M. James, Wesley Burks, Philippe Eigenmann.1. Overview of mucosal immunity and development of oral tolerance / Corinne Keet, Robert Wood -- 2. Food antigens / E. N. Clare Mills, Philip E. Johnson, Yuri Alexeev -- 3. Epidemiology of food allergy / Katrina J. Allen, Jennifer J. Koplin -- 4. Clinical overview of adverse reactions to foods / John M. Kelso -- 5. Atopic dermatitis and food allergy / Tamara T. Perry, Debra D. Becton, Stacie M. Jones -- 6. Food-induced urticaria and angioedema / Julia Rodriguez, Jesús F. Crespo -- 7. Pollen-food syndrome / Antonella Muraro, Cristiana Alonzi -- 8. Respiratory tract and food allergy / John M. James -- 9. Food-induced anaphylaxis and food associated exercise-induced anaphylaxis Motohiro Ebisawa -- 10. Eosinophilic gastroenteropathies (eosinophilic esophagitis, eosinophilic gastroenteritis and eosinophilic colitis) / Dan Atkins, Glenn T. Furuta -- 11. Food protein-induced enterocolitis syndrome, food protein-induced enteropathy, proctocolitis, and infantile colic / Stephanie Ann Leonard, Anna Nowak-Węgrzyn -- 12. Approach to the clinical diagnosis of food allergy / Jonathan O'B. Hourihane -- 13. In vivo and in vitro diagnostic methods in the evaluation of food allergy / S. Allan Bock -- 14. Oral food challenge procedures / Gideon Lack, George Du Toit, Mary Feeney -- 15. Management of food allergy and development of an anaphylaxis treatment plan / Jacqueline Wassenberg, Philippe Eigenmann -- 16. Patient education and empowerment / Kim Mudd, Robert Wood -- 17. Future therapies for food allergies / Anna Nowak-Węgrzyn, Hugh A. Sampson -- 18. Natural history and prevention of food allergy / Scott H. Sicherer, Atsuo Urisu -- 19. Diets and nutrition: cross-reacting food allergens / Vicki McWilliam -- 20. Diagnostic and therapeutic dilemmas: adverse reactions to food additives, pharmacologic food reactions, psychological considerations related to food ingestion / John O. Warner.
- 2014 Wileyedited by Dean D. Metcalfe, Hugh A. Sampson, Ronald A. Simon, Gideon Lack.
- 2015 Kargervolume editors, Motohiro Ebisawa, Barbara K. Ballmer-Weber, Stefan Vieths, Robert A. Wood.
- 2014 CRCnetBASEedited by Scott H. Sicherer, MD.Chapter 1. Clinical manifestations of food allergy / Jonathan M. Spergel and Hemant P. Sharma -- Chapter 2. Prevalence, triggers, and cross-reactivity / Lynette P. Shek and Katrina (Katie) J. Allen -- Chapter 3. Acute reactions and anaphylaxis / Corinne Keet and Julie Wang -- Chapter 4. Skin conditions associated with food allergy / Tamara T. Perry, A. Wesley Burks, and Stacie M. Jones -- Chapter 5. Gastrointestinal conditions associated with food allergy / Mirna Chehade and Seema Aceves -- Chapter 6. Respiratory conditions associated with food allergy / John M. James -- Chapter 7. Diagnostic testing / Maeve Kelleher, S. Allan Bock, and Jonathan O'B Hourihane -- Chapter 8. The oral food challenge procedure / Sally Noone and Amal H. Assa'ad -- Chapter 9. Dietary management / Marion Groetch -- Chapter 10. Managing food avoidance within the home and outside the home, and lifestyle issues / Jennifer S. Kim, Eyal Shemesh, and Michael C. Young -- Chapter 11. Pharmacologic reactions to food and reactions to food additives / Matthew J. Greenhawt, Timothy J. Franxman, and Ronald A. Simon -- Chapter 12. Prevention / George Du Toit, David M. Fleischer, and Gideon Lack -- Chapter 13. Natural course / Jessica H. Savage and Robert A. Wood -- Chapter 14. Future diagnostics and therapies / Anna Nowak-Wegrzyn and Hugh A. Sampson -- Chapter 15. Practical resources for physicians and patients / Todd A. Mahr and Maria L. Acebal.
- Footmarks of innate immunity in the ovary and cytokeratin-positive cells as potential dendritic cells2011 SpringerKatharina Spanel-Borowski.The cyclic ovary can be seen as a site of tissue damage, repair and precisely controlled tissue homeostasis, as long ovulation and luteolysis can be compared with acute and chronic inflammation. Innate immunity appears to be a powerful force in the endocrine system, representing a novel concept. In this monograph, remarkable evidence is given for the immune-privileged ovary being an implant on the chicken chorioallantoic membrane with an areactive mesenchyme. Mild to severe tissue damages due to follicular atresia, follicular rupture, or intraovarian oocyte release do no lasting harm. The most exciting part relates to the analysis of cytokeratin-positive (CK<sup>+</sup>) cells, comparing the fate mapping of this cell type from the fetal ovary to the adult organ. Findings on toll-like receptor 4 regulation and interferon-gamma-dependent positive effects indicate that CK<sup>+</sup> cells from human preovulatory follicles and bovine corpora lutea have similarities with nonlymphoid dendritic cells, a discovery that has the makings of a top story in basic and clinical research on the ovary.
- 2006 SpringerB. Pulendran and R. Ahmed (eds.).TLR signaling / S. Akira -- Dendritic cells : translating innate to adaptive immunity / R.M. Steinman and H. Hemmi -- Helper T cell-regulated B cell immunity / L.J. Mcheyzer-Williams, L.P. Malherbe, and M.G. McHeyzer-Williams -- T cell memory / J.T. Tan an C.D. Surh -- The privacy of T cell memory to viruses / R.M. Welsh ... [et al.] -- Enhancement of infectious disease vaccines through TLR9-dependent recognition of CpG DNA / M.J. McCluskie and A.M. Krieg.
- 2008 Ovideditor, William E. Paul.
- 2013 Ovideditor, William E. Paul.Section I: Introduction to immunology -- chapter 1. The immune system / William E. Paul -- chapter 2. History of immunology / Steven Greenberg -- Section II: Organization and evolution of the immune system -- chapter 3. Lymphoid tissues and organs / Eitan M. Akirav ... [et al.] -- chapter 4. Evolution of the immune system / Martin F. Flajnik and Louis Du Pasquier -- Section III: Immunoglobulins and B-lymphocytes -- chapter 5. Immunoglobulins: structure and function / Harry W. Schroeder Jr., David Wald, and Neil S. Greenspan -- chapter 6. Immunoglobulins: molecular genetics / Edward E. Max and Sebastian Fugmann -- chapter 7. Antigen-antibody interactions and monoclonal antibodies / Jay A. Berzofsky and Ira J. Berkower -- chapter 8. B-lymphocyte development and biology / Richard R. Hardy -- chapter 9. B-lymphocyte receptors, signaling mechanisms, and activation / Akanksha Chaturvedi ... [et al.] -- chapter 10. B-lymphocyte responses / Michael McHeyzer-Williams -- Section IV: T-lymphocytes -- chapter 11. T-cell antigen receptors / Mark M. Davis and Yueh-Hsiu Chien -- chapter 12. Mechanisms of T-lymphocyte signaling and activation / Takashi Saito -- chapter 13. T-lymphocyte developmental biology / Ellen V. Rothenberg and Ameya Champhekar -- chapter 14. Peripheral T-lymphocyte responses and function / Marc K. Jenkins -- Section V: The intersection of innate and adaptive immunity -- chapter 15. The innate immune system / Luke A. J. O'Neill -- chapter 16. Dendritic cells / Kang Liu, Michel C. Nussenzweig -- chapter 17. Natural killer cells / Wayne M. Yokoyama -- chapter 18. CD1d-restricted natural killer T-cells / Albert Bendelac -- chapter 19. Macrophages and phagocytosis / Siamon Gordon -- chapter 20. Granulocytes and mast cells / Patrizia Scapini ... [et al.] -- chapter 21. The major histocompatibility complex and its proteins / David H. Margulies ... [et al.] -- chapter 22. Antigen processing and presentation / Ted H. Hansen and Paul A. Roche -- Section VI: Induction, regulation, and effector functions of the immune response -- chapter 23. Immunogenicity and antigen structure / Jay A. Berzofsky and Ira J. Berkower -- chapter 24. Rc receptors and their role in immune regulation and inflammation / Jeffrey V. Ravetch and Falk Nimmerjahn -- chapter 25. Type I cytokines and interferons, and their receptors / Warren J. Leonard -- chapter 26. The interleukin-1 family / Charles A. Dinarello and Mihai G. Netea -- chapter 27. Tumor necrosis factor-related cytokines in immunity / Carl F. Ware -- chapter 28. Chemokines / Philip M. Murphy -- chapter 29. Helper T-cell differentiation and plasticity / John J. O'Shea -- chapter 30. Programmed cell death / Andrew L. Snow and Michael J. Lenardo -- chapter 31. Immunologic memory / Shane Crotty, Susan M. Kaech, and Stephen P. Schoenberger -- chapter 32. Immunologic tolerance / Christopher C. Goodnow and Pamela S. Ohashi -- chapter 33. Regulatory/suppressor T-cells / Ethan M. Shevach -- chapter 34. The mucosal immune system / Yasmine Belkaid -- chapter 35. Neurophysiologic reflex mechanisms in immunology / Sangeeta S. Chavan and Kevin J. Tracey -- chapter 36. Complement / B. Paul Morgan -- chapter 37. Cell-mediated cytotoxicity / Judy Lieberman -- Section VII: Immunity to infectious agents -- chapter 38. The immune response to parasites / Thomas A. Wynn ... [et al.] -- chapter 39. Immunity to viruses / Hildegund C. J. Ertl -- chapter 40. Immunity to intracellular bacteria / Anca Dorhoi, Stephen T. Reece, and Stefan H. E. Kaufmann -- chapter 41. Immunity to extracellular bacteria / Moon H. Nahm and Jannet Katz -- chapter 42. Immunology of human immunodeficiency virus infection / Douglas S. Kwon and Bruce D. Walker -- chapter 43. Vaccines / Ennio De Gregorio ... [et al.] -- Section VIII: Immunologic mechanisms in disease -- chapter 44. Autoimmunity and autoimmune diseases / Ken T. Coppieters, Matthias G. von Herrath, and Dirk Homann -- chapter 45. Immunologic mechanisms of allergic disorders / Marsha Wills-Karp and Ian Lewkowich -- chapter 46. Transplantation immunology / Megan Sykes, Kathryn Wood, and David H. Sachs -- chapter 47. Cancer immunology / Hans Schreiber -- chapter 48. Inborn errors of immunity / Jean-Laurent Casanova, Mary Ellen Conley, and Luigi D. Notarangelo.
- 2002 Kargervolume editors, Michael Breitenbach, Reto Crameri, Samuel B. Lehrer.Also available: Print – 2002
- Fungal biofilms and related infections : advances in microbiology, infectious diseases and public health. Volume 32016 SpringerChristine Imbert, editor.Aspergillus biofilms in human disease -- Candida albicans in multispecies oral communities: a keystone commensal? -- The extracellular matrix of fungal biofilms -- Fungal biofilms: update on resistance -- Fungi, water supply and biofilms -- Diagnostic of fungal infections related to biofilms -- Disinfectants to fight oral Candida biofilms -- Updates on therapeutic strategies against Candida (and Aspergillus) biofilm related infections -- Natural sources as innovative solutions against fungal biofilms -- Index.Also available: Print – 2016
- 2005 Springeredited by Paul L. Fidel, Jr., Gary B. Huffnagle.
- 2001 Kargervolume editors, Paul R. Bergstresser, A. Takashima.T cell receptor and function cosegregate in gamma-delta T cell subsets -- Role of the IL-7 receptor in gamma-delta T cell development -- Epidermal and dermal gamma-delta T cells -- Cytokine profiles and responsiveness of dendritic epidermal T cells: cytokine-mediated communication with other cells -- Gamma-delta T cells with emphasis on their functional role in the epidermis -- Role of gamma-delta T cells in cutaneous hypersensitivity reactions -- Gamma-delta T cells: immunoregulatory functions and immunoprotectionAlso available: Print – 2001
- 2005 Springer[edited by] Gérald J. Prud'homme.Gene therapy approaches for autoimmune diseases of the central nervous system and other tissues / Roberto Furlan ... [et al.] -- Gene therapeutics in autoimmune diabetes / Jon D. Piganelli, Massimo Trucco, and Nick Giannoukakis -- Immunogene therapy with nonviral vectors / Ciriaco A. Piccirillo, Argyrios N. Theofilopoulos, and Gérald J. Prud'homme -- Targeting antigen-specific T cells for gene therapy of autoimmune disease / Justin M. Johnson and Vincent K. Tuohy -- Therapeutic gene transfer for rheumatoid arthritis / Natacha Bessis and Marie-Christophe Boissier -- Gene therapy-based approach for immune tolerance induction using recombinant immunoglobulin carriers / Moustapha El-Amine ... [et al.] -- DNA vaccination against autoimmune diseases / Gérald J. Prud'homme ... [et al.].
- 2012 SpringerJosef Thalhamer, Richard Weiss, Sandra Scheiblhofer, editors.
- 2012 Springeredited by Ryuya Yamanaka.Molecular biology of glioma / Tomotoshi Marumoto and Hideyuki Saya -- Recent surgical management of gliomas / Nader Sanai and Mitchel S. Berger -- Recent medical management of glioblastoma / Derek R. Johnson and Susan M. Chang -- Basic concepts in glioma immunology / Ian F. Parney -- Mechanisms of immune evasion by gliomas / Cleo E. Rolle, Sadhak Sengupta, and Maciej S. Lesniak -- Glioma antigen / Masahiro Toda -- Cytokine therapy / Masasuke Ohno, Atsushi Natsume, and Toshihiko Wakabayashi -- Immunotherapeutic approach with oligodeoxynucleotides containing CpG motifs (CpG ODN) in malignant glioma / Renata Ursu and Antoine F. Carpentier -- Adoptive cell transfer therapy for malignant gliomas / Eiichi Ishikawa ... [et al.] -- Monoclonal antibody therapy for malignant glioma / Kevin S. Chen and Duane A. Mitchell -- Animal models for vaccine therapy / Dong-Sup Chung, Chang-Hyun Kim, and Yong-Kil Hong -- Immunogene therapy / Terry Lichtor and Roberta P. Glick -- Peptide vaccine / Shuichi Izumoto -- Active immunotherapy : oncolytic virus therapy using HSV-1 / Tomoki Todo -- Dendritic cell vaccines / Ryuya Yamanaka and Koji Kajiwara -- Antigen-receptor gene-modified T cells for treatment of glioma / Hiroaki Ikeda and Hiroshi Shiku -- Glioma stem cell research for the development of immunotherapy / Qijin Xu, Xiangpeng Yuan, and John S. Yu.Also available: Print – 2012
- 2014editors, Cezmi A. Akdis, Ioana Agache ; editorial board, Pascal Demoly, Peter Hellings, Antonella Muraro, Nikolaos G. Papadopoulos, Ronald van Ree.
- 2012Joshua Asher Weinstein.The adaptive immune system enables individuals to defend against previously un-encountered pathogens by trial and error. It does so by employing receptors, known as antibodies, whose active genetic diversification fine-tunes this defensive response. Tremendous progress has been made in understanding the mechanisms by which antibodies develop and signal activation. However, it was not until a few years ago, with the advent of affordable in-house high-throughput DNA sequencing, and our publication of whole zebrafish antibody repertoires, that any organism's antibody diversity was characterized comprehensively. In this dissertation, we demonstrate the power of this "top-down" approach to illuminate global, system-wide changes of immune receptor repertoires during organism development and immune response. Special attention is given to applying these measurements to build predictive dynamical models that elucidate the interplay between antibody-sequences and the B-cells that produce them. While we use zebrafish liberally as a model organism for these purposes, cross-species comparisons establish far more general principles of repertoire organization. We go further to evaluate the efficacy of high-throughput immune receptor sequencing to advance clinical goals by inferring which vaccines were received by human patients based on antibody-sequences obtained from whole blood afterward. Finally, we demonstrate the usefulness of single B-cell measurements to correlate antibody mutations to gene expression, thereby providing insight into how these variables co-vary system-wide. This work serves to illustrate the potential of global characterizations of antibody repertoires for providing newer and clearer pictures of immune dynamics in general.
- 2005 Springeredited by John S. Axford.
- 2009 SpringerE. Nigel Wardle.
- 2012 Springer Protocolsedited by Alexander E. Kalyuzhny.Unique strengths of ELISPOT for T cell diagnostics / Paul V. Lehmann and Wenji Zhang -- The impact of harmonization on ELISPOT assay performance / Sylvia Janetzki and Cedrik M. Britten -- Equine ELISPOT assay to study secretion of IFN[gamma] and IL-4 from peripheral blood mononuclear cells / Jodi Hagen [and others] -- Utilization of feline ELISPOT for mapping vaccine epitopes / Jeffrey R. Abbott [and others] -- Analyzing cellular immunity to AAV in a canine model using ELISPOT assay / Zejing Wang [and others] -- Dual- and triple-color fluorospot / Niklas Ahlborg and Bernt Axelsson -- ELISPOT assay as a tool to study oxidative stress in lymphocytes / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay for neuroscience research : studying TNF[alpha] secretion from microglial cells / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- ELISPOT assay as a tool to study the effects of stem cells on cytokine secretion / Jun-Seop Shin and Chung-Gyu Park -- Combining ELISPOT and ELISA to measure amounts of cytokines secreted by a single cell / Jodi Hagen, Jeffrey P. Houchins, and Alexander E. Kalyuzhny -- How ELISPOT morphology reflects on the productivity and kinetics of cells' secretory activity / Alexey Y. Karulin and Paul V. Lehmann -- Mathematical algorithms for automatic search, recognition, and detection of spots in ELISPOT assay / Sergey S. Zadorozhny and Nikolai N. Martynov -- Objective, user-independent ELISPOT data analysis based on scientifically validated principles / Wenji Zhang and Paul V. Lehmann -- Statistical analysis of ELISPOT assays / Marcus Dittrich and Paul V. Lehmann -- Response determination criteria for ELISPOT : toward a standard that can be applied across laboratories / Zoe Moodie [and others] -- Detection of Vaccinia virus-specific IFN[gamma] and IL-10 secretion from human PBMCs and CD8 T cells by ELISPOT / Benjamin J. Umlauf [and others] -- ELISPOT assays to enumerate bovine IFN-[gamma]-secreting cells for the development of novel vaccines against bovine tuberculosis / Martin Vordermeier and Adam O. Whelan -- IL-7 addition increases spot size and number as measured by T-SPOT. TB® / Marsha L. Feske [and others] -- Overview of membranes and membrane plates used in research and diagnostic ELISPOT assays / Alan J. Weiss.
- 2008 CRCnetBASEedited by Maurice R.G. O'Gorman, Albert D. Donnenberg.Overview of immunity / James D. Folds -- Statistics of immunological testing / Albert D. Donnenberg -- Human immunoglobulins / Robert G. Hamilton -- The complement system / Patricia C. Giclas -- Cellular immunology : monitoring of immune therapies / Theresa L. Whiteside -- Understanding clinical flow cytometry / Albert D. Donnenberg and Vera S. Donnenberg -- Leukemia and lymphoma immunophenotyping and cytogenetics / Maria A. Proytcheva -- Guidelines for the use of flow cytometry in the management of patients infected with the human immunodeficiency virus type-1 and the acquired immunodeficiency syndrome / Maurice R.G. O'Gorman -- Role of flow cytometry in the diagnosis and monitoring of primary immunodeficiency disease / Maurice R.G. O'Gorman -- Detection and characterization of the T-cell receptor repertoire / Gulbu Uzel -- Human leukocyte differentiation antigens, cluster of differentiation : past, present, and future / Maurice R.G. O'Gorman -- Immunologic diagnosis of autoimmunity / Noel R. Rose -- Autoimmune and immune-mediated diseases of the gastrointestinal tract / Stefano Guandalini, Mala Setty, and Bana Jabri -- Serologic testing for infectious diseases / John L. Schmitz -- Molecular techniques applied to infectious diseases / Jennifer S. Goodrich and Melissa B. Miller -- Cytokines : regulators of immune responses and key therapeutic targets / Barbara Detrick, Chandrasekharam N. Nagineni, and John J. Hooks -- Measuring human cytokines / Holden T. Maecker -- The human major histocompatibility complex and DNA-based typing of human leukocyte antigens for transplantation / Susana G. Marino, Andrés Jaramillo, and Marcelo A. Fernández-Viña -- Relevance of antibody screening and crossmatching in solid organ, hematopoietic stem cell transplantation, and blood transfusion / Chee L. Saw ... [et al.] -- Functional assessment of immunosuppression : monitoring posttransplant alloreactivity with flow cytometric mixed lymphocyte cocultures / Chethan Ashok Kumar ... [et al.].
- 2015 SpringerFan Lin, Jeffrey Prichard, editors.In a conceptually current, quick-reference, Question & Answer format, the second edition of Handbook of Practical Immunohistochemistry: Frequently Asked Questions continues to provide a comprehensive and yet concise state-of-the-art overview of the major issues specific to the field of immunohistochemistry. With links to the authors Immunohistochemical Laboratory website, this volume creates a current and up-to-date information system on immunohistochemistry. This includes access to tissue microarrays (TMA) of over 10,000 tumors and normal tissue to validate common diagnostic panels and provide the best reproducible data for diagnostic purposes. ℗l Fully revised and updated from the first edition, the new features of the second edition include over 200 additional questions or revised questions with an IHC panel to answer each question; over 250 new color photos and illustrations; over 20 new useful biomarkers; hundreds of new references; several new chapters to cover phosphoproteins, rabbit monoclonal antibodies, multiplex IHC stains, overview of predictive biomarkers, and integration of IHC into molecular pathology; many new coauthors who are international experts in a related field; many updated IHC panels using Geisinger IHC data collected from over 10,000 tumors and normal tissues; and updated appendices containing detailed antibody information for both manual and automated staining procedures. ℗l Comprehensive yet practical and concise, the Handbook of Practical Immunohistochemistry: Frequently Asked Questions, Second Edition will be of great value for surgical pathologists, pathology residents and fellows, cytopathologists, and cytotechnologists.
- 2011 SpringerFan Lin, Jeffrey Prichard, editors ; Haiyan Liu, Myra Wilkerson, Conrad Schuerch, assoc. editors.Quality management and regulation / Jeffrey Prichard -- Technique and troubleshooting of antibody testing / Fan Lin and Jianhui Shi -- Overview of automated immunohistochemistry / Jeffrey Prichard, Angela Bitting, and Joe Myers -- Automated staining : Dako perspective / Ole F. Rasmussen and Andreas Schønau -- Automated staining : Ventana perspective / Angela Sattler -- Tissue microarray / Myra Wilkerson and Erin Powell -- Unknown primary/undifferentiated neoplasms in surgical and cytologic specimens / Fan Lin and Haiyan Liu -- Exfoliative cytopathology / Steven Meschter and Jan F. Silverman -- Predictive markers of breast cancer : ER, PR, and HER2 / Jeffrey Prichard, David Hicks, and Elizabeth Hammond -- Central and peripheral nerve system tumors / Hueizhi (Hope) Wu, Conrad Schuerch, and Douglas C. Miller -- Thyroid and parathyroid gland / Haiyan Liu, Fan Lin, and Ronald A. DeLellis -- Adrenal gland / Hanna G. Kaspar -- Salivary gland and other head and neck structures / Conrad Schuerch -- Lung, pleura, and mediastinum / Kai Zhang and Phillip Cagle -- Breast / Haiyan Liu -- Uterus / Hanna G. Kaspar -- Ovary / Jeffrey Prichard, Haiyan Liu, and Myra Wilkerson -- Prostate gland / Haiyan Liu, Fan Lin, and Qihui (Jim) Zhai -- Urinary bladder / Myra Wilkerson -- Kidney / Fan Lin and Ximing J. Yang -- Testis and paratesticular tissues / Myra Wilkerson -- Pancreas and ampulla / Fan Lin and Hanlin L. Wang -- Liver, bile ducts, and gallbladder / Jeffrey Prichard and Fan Lin -- Upper gastrointestinal tract / Jinhong Li and Fan Lin -- Lower gastrointestinal tract and microsatellite instability / Jinhong Li and Fan Lin -- Soft tissue and bone tumors / Shaobo Zhu and Markku Miettinen -- Lymph node / Xiaohong (Mary) Zhang and Nadine S. Aguilera -- Bone marrow / R. Patrick Dorion and Xiaohong (Mary) Zhang -- Infectious diseases / Dirk M. Elston, Lawrence E. Gibson, and Heinz Kutzner -- Skin / Tammie Ferringer -- Application of direct immunofluorescence for the skin and mucosal biopsies : a practical review / William B. Tyler -- In situ hybridization in surgical and cytologic specimens / Hong Yin and Barbara Paynton.
- v. 1-, 2004- ScienceDirect
- 2009 Springereditors, Tamas Fulop, Claudio Franceschi, Katsuiku Hirokawa, Graham Pawelec.
- Helicobacter pylori : molecular mechanisms for the utilization of the cell surface as a replicative niche2010Shumin Tan.Helicobacter pylori is a bacterium that chronically infects the stomachs of more than half the human population, in some cases leading to serious diseases such as gastric cancer and ulcers. H. pylori intimately interact with the gastric epithelial surface, but much remains unknown about its life on the cell surface. The bacterium possesses several tools for its close interaction with the gastric epithelia, including a type IV secretion system, through which the virulence factor CagA is directly translocated into host cells. This dissertation focuses on how H. pylori's close interactions with the epithelial cells allows it to modify the apical cell surface to turn it into a replicative niche for the bacterium. Using live-cell microscopy to follow the fate of individual bacteria on the cell surface, we find that H. pylori is able to utilize the apical cell surface as a replicative niche, even in conditions that do not support the growth of free-swimming bacteria. Experiments with a polarized epithelial model system show that the bacterium's major virulence factors CagA and VacA both play important roles in enabling H. pylori growth and microcolony formation on the apical cell surface, by mediating perturbation of host cell polarity and intracellular trafficking processes. We find that iron is one important micronutrient that H. pylori acquires from host cells during colonization of the polarized epithelium. CagA and VacA act in concert to affect the polarized process of transferrin/transferrin receptor recycling and iron uptake in the host cells, resulting in the mis-sorting of a subset of the transferrin/transferrin receptor complex to the colonizing bacteria on the apical cell surface. This process is functionally important for the bacteria, as downregulation of transferrin receptor expression resulted in a decreased ability of H. pylori to colonize the polarized epithelium. These studies establish the cell surface as a replicative niche, which presents challenges that require bacterial adaptation for its successful utilization. Our findings also illustrate the concept that contact-dependent bacterial virulence factors may be used for the perturbation of host cell physiology for the bacterium's benefit, allowing acquisition of needed factors directly from host cells, and colonization of the apical cell surface.
- 2012 ClinicalKeyedited by Eric D. Hsi.Section 1. Non-neoplastic disorders -- section 2. Lymphomas -- section 3. Leukemias, chronic myeloproliferative neoplasms, and myelodysplasia -- section 4. Disorders of histiocytes, mast cells, plasma cells, spleen, and ancillary techniques.
- 2012 SpringerBenhur Lee, Paul A. Rota, editors.Introduction: Nipah Virus--Discovery and Origin / Kaw Bing Chua -- Ecological Aspects of Hendra Virus / Hume Field, Gary Crameri, Nina Yu-Hsin Kung and Lin-Fa Wang -- Epidemiology of Henipavirus Disease in Humans / Stephen P. Luby and Emily S. Gurley -- Molecular Virology of the Henipaviruses / Paul A. Rota and Michael K. Lo -- Henipavirus Receptor Usage and Tropism / Olivier Pernet, Yao E Wang and Benhur Lee -- Henipavirus Membrane Fusion and Viral Entry / Hector C. Aguilar and Ronald M. Iorio -- Clinical and Pathological Manifestations of Human Henipavirus Infection / K. T. Wong and C. T. Tan -- Henipaviruses in Their Natural Animal Hosts / D. J. Middleton and H. M. Weingartl -- Nipah and Hendra Virus Interactions with the Innate Immune System / Christopher F. Basler -- Animal Challenge Models of Henipavirus Infection and Pathogenesis / Thomas W. Geisbert, Heinz Feldmann and Christopher C. Broder -- Diagnosis of Henipavirus Infection: Current Capabilities and Future Directions / Lin-Fa Wang and Peter Daniels -- Immunization Strategies Against Henipaviruses / Christopher C. Broder, Thomas W. Geisbert, Kai Xu, Dimitar B. Nikolov and Lin-Fa Wang, et al.
- 2013 Springeredited by Ralf Bartenschlager.Hepatitis C virus (HCV), a major causative agent of chronic liver disease, is spread throughout the world and around 170 million people are persistently infected. In this volume, world-leading experts in the field of HCV research have compiled the most recent scientific advances to provide a comprehensive and very timely overview of the various facets of HCV. The book starts with a discussion of the possible origin of HCV and its spread among the human population. The focus of the subsequent chapters is on available cell culture and in vivo models before shifting to the molecular and cellular principles underlying the viral replication cycle. These chapters are complemented by insightful descriptions of the innate and adaptive immune responses to HCV as well as the virus-associated pathogenesis. Finally, the development of antiviral therapies, which is closely linked with progress in basic research, and the implementation of those therapies into present and future daily clinical practice are highlighted.
- 2008 SpringerEmilio Jirillo, editor.Innate immunity in type C hepatitis / Tetsuo Takehara and Norio Hayashi -- Mechanisms of interferon action and resistance in chronic hepatitis C virus infection: lessons learned from cell culture studies / Srikanta Dash ... [et al.] -- Immunological parameters influencing adaptive immune responses to the hepatitis C virus / Patrick Bertolino, Geoffrey W. McCaughan, and David G. Bowen -- Immune responses against the hepatitis C virus and the outcome of therapy / Paul Klenerman and Eleanor Barnes -- Other microbial components associated with hepatitis C virus infection: their effects on interferon- a/ribavirin treatment / Luigi Amati, Vittorio Pugliese, and Emilio Jirillo -- Interferon-induced effector proteins and hepatitis C virus replication / Michael Frese and Eva Dazert -- Treatment of chronic hepatitis C with different genotypes / James Fung, Ching-Lung Lai, and Man-Fung Yuen -- Interferon treatment of hepatitis C virus infection: from basic biology to clinical application / Norihiro Furusyo, Masayuki Murata, and Jun Hayashi -- Interferon-based therapy for hepatitis C virus infections / Ming-Lung Yu and Wan-Long Chuang -- Treatment of chronic hepatitis C in "difficult-to-treat" patients in the clinical setting / Ana Moreno, Rafael Bárcena, and Carmen Quereda -- Effects of combined IFN-alpha/ribavirin treatment in HCV disease-related progression / Davide Festi ... [et al.] -- Pegylated interferons: clinical applications in the management of hepatitis C infection / S. James Matthews and Christopher McCoy.
- 2014 SpringerAllan R. Brasier, editor.Asthma is a chronic relapsing airways disease that represents a major public health problem worldwide. Intermittent exacerbations are provoked by airway mucosal exposure to pro-inflammatory stimuli, with RNA viral infections or inhaled allergens representing the two most common precipitants. In this setting, inducible signaling pathways the airway mucosa play a central role in the initiation of airway inflammation through production of antimicrobial peptides (defensins), cytokines, chemokines and arachidonic acid metabolites that coordinate the complex processes of vascular permeability, cellular recruitment, mucous hyper-secretion, bronchial constriction and tissue remodeling. These signals also are responsible for leukocytic infiltration into the submucosa, T helper-lymphocyte skewing, and allergic sensitization. Currently, it is well appreciated that asthma is a heterogeneous in terms of onset, exacerbants, severity, and treatment response. Current asthma classification methods are largely descriptive and focus on a single aspect or dimension of the disease. An active area of investigation on how to collect, use and visualize multidimensional profiling in asthma. This book will overview multidimensional profiling strategies and visualization approaches for phenotyping asthma. As an outcome, this work will facilitate the understanding of disease etiology, prognosis and/or therapeutic intervention.Also available: Print – 2014
- 2010 Springeredited by Robin L. Thurmond.One hundred years of histamine research / Katherine Figueroa and Nigel Shankley -- Molecular pharmacology of the four histamine receptors / Gerold Bongers, Iwan de Esch, and Rob Leurs -- Histamine synthesis and lessons learned from histidine decarboxylase deficient mice / Hiroshi Ohtsu -- Abstract -- Histamine in allergic rhinitis / Thomas Taylor-Clark -- The role of histamine in ocular allergy / Masaharu Ohbayashi ... [et al.] -- The role of histamine in asthma / Paul J. Dunford and Stephen T. Holgate -- Antihistamines in the treatment of urticaria / Torsten Zuberbier and Marcus Maurer -- Histamine and antihistamines in atopic dermatitis / Jørg Buddenkotte, Marcus Maurer, and Martin Steinhoff -- Histamine, immune cells, and autoimmunity / Elke Schneider, Maria Leite-de-Moraes, and Michel Dy -- Histamine in neurotransmission and brain diseases / Saara Nuutinen and Pertti Panula -- Histamine in normal and malignant cell proliferation / Andras Falus, Zoltøn Pøs, and Zsuzsanna Darvas -- The future antihistamines : histamine H3 and H4 receptor ligands / Fuqu Yu, Pascal Bonaventure, and Robin L. Thurmond.
- 2015 SpringerReinhart Jarisch, editor.Histamine is an important mediator of allergic diseases such as hay fever and bronchial asthma, food allergies, urticaria, and drug hypersensitivity. Knowledge of histamine as a cause of numerous non-allergic symptoms and signs is, however, limited. In fact, histamine intolerance can be responsible for conditions as diverse as seasickness, headaches and migraine, tachycardia, gastric disorders, diarrhea, intolerance to contrast media, parodontosis, period pains, nausea and vomiting in pregnancy, atopic dermatitis, and osteoporosis. This book offers wide-ranging coverage of histamine intolerance. There is extensive background discussion of the origin of histamine, its content in food and alcoholic beverages, and intolerance to red wine. Diagnosis of histamine intolerance is explained, and the various symptoms of histamine intolerance are clearly described. Subsequent chapters cover the conditions mentioned above and also consider the relation of histamine to vitamin B6 and the specific immunotherapy of allergies. This book will prove of value in clinical practice by facilitating differential diagnosis, which is by no means straightforward given the multiplicity of symptoms of histamine intolerance, and by assisting in the selection of therapeutic measures.
- 2014 Kargereditors K.-C. Bergmann and J. Ring.
- 2009 ScienceDirectArthur M. Silverstein.
- 2014 ScienceDirectZoltan A. Nagy.A History of Modern Immunology: A Path Toward Understanding describes, analyzes, and conceptualizes several seminal events and discoveries in immunology in the last third of the 20th century, the era when most questions about the biology of the immune system were raised and also found their answers. Written by an eyewitness to this history, the book gives insight into personal aspects of the important figures in the discipline, and its data driven emphasis on understanding will benefit both young and experienced scientists. This book provides a concise introduction to topics including immunological specificity, antibody diversity, monoclonal antibodies, major histocompatibility complex, antigen presentation, T cell biology, immunological tolerance, and autoimmune disease. This broad background of the discipline of immunology is a valuable companion for students of immunology, research and clinical immunologists, and research managers in the pharmaceutical and biotechnology industries. Contains the history of major breakthroughs in immunology featured with authenticity and insider detailsGives an insight into personal aspects of the players in the history of immunologyEnables the reader to recognize and select data of heuristic value which elucidate important facets of the immune systemProvides good examples and guidelines for the recognition and selection of what is important for the exploration of the immune systemGives clear separation of descriptive and interpretive parts, allowing the reader to distinguish between facts and analysis provided by the author.
- 2011 SpringerStanley A. Plotkin, editor."The history of vaccines now goes back over 300 years to the work of Jenner but the last 50 years have seen an enormous acceleration of the pace of vaccine development and, accordingly, the impact on infectious diseases. However, no vaccine development has been easy and there is an interesting story attached to each. The editor of this book brought together a number of the scientists responsible for modern vaccines and historians familiar with the stories about the ones developed in earlier centuries. The chapters in this book recount the hard work and detours that are intimately associated with vaccine development and give some sense of the perseverance that gave public health the tools of modern preventive medicine."--Publisher's website.
- 2009 Springeredited by Robert H. Paul, Ned Charles Sacktor, Victor Valcour, Karen Tokie Tashima.Neurocognitive changes in AIDS: evolution of treatment of HIV infection / Erna Milunka Kojic and Charles C.J. Carpenter -- Global incidence and epidemiology of the AIDS pandemic, distribution of HIV subtypes, and epidemiology of hepatitis C infection among HIV-positive individuals / Karen T. Tashima and Aadia I. Rana -- New insights into HIV neuropathogenesis / Tory P. Johnson and Avindra Nath -- Neuropathological findings associated with long-term HAART / Iain C. Anthony and Jeanne E. Bell -- Biomarkers of HIV-related central nervous system disease / Bruce James Brew and Scott Letendre -- Neuroimaging among HIV-infected patients: current knowledge and future directions / David F. Tate ... [et al.] -- The assessment of HIV-associated neurocognitive disorders: new challenges in the HAART era / Lucette A. Cysique and Bruce J. Brew -- The changing face of HIV-associated cognitive and neuropsychiatric disturbance / Ron Cohen -- Youth with HIV/AIDS: neurobehavioral consequences / Susannah Allison, Pamela L. Wolters, and Pim Brouwers -- Co-occurrence of HIV, hepatitis C, and substance use disorders: effects on brain functioning / Raul Gonzalez, Phillip J. Quartana, and Eileen M. Martin -- The functional impact of HIV-associated neuropsychological decline / Matthew J. Wright ... [et al.] -- Adjunctive therapy for long-term support of cognitive impairment / Joshua T. Dearborn ... [et al.] -- HIV-1 genetic diversity and its biological significance / Michael M. Thomson -- Opportunistic infections in the brain in developing countries / Marcus Tulius T. Silva and Beatriz Grinsztejn -- Impact of Clade diversity on neuropsychological outcomes / Robert Paul ... [et al.] -- The effects of aging on HIV disease / Robert C. Kalayjian and Lena Al-Harthi -- Neuropsychology of healthy aging / Molly E. Zimmerman and Adam M. Brickman -- Interactions between advanced age and HIV cognitive impairment / Victor Valcour and Aaron M. McMurtray.
- 2014 SpringerRalph Pantophlet, editor.Glycosylation is a common and extremely important modification in biological molecules, particularly of proteins. HIV Glycans in Infection and Immunity provides an overview of the roles of glycans in the transmission/infection, antigenicity, and immunogenicity of HIV and the HIV envelope glycoprotein. It explores recent advances in the understanding of the impact of HIV glycans in infection and their promise for immunological and therapeutic intervention. Novel collaborations between glycobiologists and immunologists in recent years have led to key advances in the understanding of HIV glycans. These cross-disciplinary endeavors, their achievements and their impact on the field are all addressed, herein.-- Source other than Library of Congress.
- 2012Josephine Y. Lee.Helicobacter pylori is a human specific pathogen that chronically infects the stomachs of over half of the world's population. Infection with H. pylori strains expressing the virulence factor, CagA, greatly increases the risk of developing gastric cancer, although only a subset of infected individuals develop severe disease. It is therefore important to define factors that contribute to disease progression in the context of H. pylori infection. This body of work began with developing a CagA+ mouse model in which both H. pylori and mouse genetics can be used to study disease development. Using this system, we have identified three novel factors that influence disease progression. Two months after oral infection, mice develop precancerous lesions such as mucous metaplasia. However, animals infected as neonates are protected from developing lesions compared to mice infected as adults, suggesting that the age of infection is an important risk factor for disease development. Using 3D confocal microscopy, we discovered that H. pylori preferentially colonizes gastric glands in the antrum of the stomach. A chemotaxis mutant that is unable to properly sense and respond to its environment can colonize the surface of the stomach but fails to colonize the mid-gastric glands. Development of pathology is reduced in animals infected with the chemotaxis mutant, indicating that bacterial factors that affect localization of H. pylori within the glands is important for disease progression. Surprisingly, we discovered that the severity of pathology in genetically identical C57BL/6 mice from two different vendors is dramatically different. Mice from one vendor develop an antrum-dominant infection and inflammation, but fail to develop precancerous lesions. Mice from the second vendor develop precancerous lesions, and the infection and inflammatory response are distributed throughout the stomach. Our findings align with disease progression observed in human infection with H. pylori, in which an antrum-dominant gastritis is protective against cancerous lesions and pan-gastritis is associated with gastric cancer development. We suspected that the gut microbiota is an environmental factor that influences differences in H. pylori localization and host pathology. By co-housing animals from the two vendors or perturbing the flora with antibiotics prior to infection with H. pylori, we found that both bacterial localization and pathology could be shifted to the corpus in the animals from the first vendor, suggesting that the microbiota may influence H. pylori localization and disease progression. Since mice from second vendor had a dominant phenotype in the co-housing experiments, we compared the gut microbiota composition of the animals by sequencing fecal samples obtained before and after co-housing. The microbiota of the animals from the two vendors were different prior to co-housing, but after co-housing, the microbiota of both groups was similar to the animals from the second vendor. These findings support the observation that mice from the first vendor phenocopy mice from the second vendor after co-housing. We are currently identifying specific components of the microbiota that may be responsible for shifting the phenotype. Analysis of differences in the immune response of animals from the two vendors suggest that the microbiota may shift the immune balance in response to H. pylori infection and lead to differential disease outcomes. Using our mouse model of infection, we have identified novel host, bacterial and environmental factors that contribute to H. pylori-induced disease progression.
- 2013Smita Gopinath.Host-adapted pathogens depend on their host for transmission and dissemination to new hosts. Salmonella enterica includes a plethora of serovars that cause host-adapted diseases in both livestock animals and humans, an example of which is Salmonella enterica serovar Typhi, the causative agent of typhoid fever. Epidemiological and mathematical modeling data indicate that a specific subset of infected hosts are responsible for the majority of disease transmission. Human typhoid carriers are a classic example of this subset, characterized by persistently infected yet asymptomatic individuals who transmit disease via the fecal oral route. The work contained in this thesis attempts to answer how carriers differ from other hosts, in particular how the host immune response in carriers allows those individuals to remain asymptomatic despite the large numbers of Salmonella in the gastrointestinal tract. We use a mouse model of persistent Salmonella infection wherein a subset of the infected hosts (super-shedders) are able to transmit disease to naive cage mates. Having characterized the development of the host immune response during chronic Salmonella infection, we identify an immune state unique to super-shedder hosts. The super-shedder immune phenotype consists of an active innate immune response with high frequency of neutrophils and serum Interleukin-6 and a suppressed adaptive T cell response with dampened cytokine responsiveness. Administration of Granulocyte colony stimulating factor to moderate-shedders is sufficient to phenocopy the blunted T cell responses of the super-shedder immune state demonstrating that neutrophils control the suppression of the adaptive T cell response. The super-shedder immune state also serves a functional purpose, protecting the host against antibiotic-driven dysbiosis. The microbiota and host-pathogen interactions together induce a unique state of tolerance in Salmonella carriers, potentially contributing to the transmission of the pathogen in the general population.
- 2010Andrew Hotson.The immune response to a pathogen is a complex interplay between host factors aimed to eradicate the pathogen, and microbe virulence proteins designed to subvert the host. To successfully combat a pathogen, the host must identify the insult and activate an immune response tailored to eliminate the specific microbe. This entails cell signaling at the level of innate immunity to detect the pathogen and mount an immediate non-specific response, while also communicating to bystander cells to shape the scope of the adaptive arm of immunity. The work herein investigates how the intracellular signaling network is activated and perturbed across cell types and hematopoietic tissues during bacterial infection. An introductory background on the current knowledge in the field of immune signaling is provided in chapter 1. Antigen presenting cells detect pathogenic motifs via pattern recognition receptors including toll-like receptors. This triggers an intracellular signaling cascade with specific transcriptional consequences, including the production of cytokines. In turn, these cytokines alert additional cell types to activate specific signal transducer and activator of transcription (STAT) transcription factor family members. Thus, detection of a microbe initiates rapid signaling across leukocytes to set the stage for the immune response. Chapter 2 focuses on cell signaling experiments in a murine model for the onset of sepsis. Mice were acutely challenged with avirulent E. coli and Listeria monocytogenes to study the host response without pathogenic manipulation of host signaling by bacterial virulence factors. Bacterial challenge causes macrophages and dendritic cells to become attenuated in their ability to respond to TLR agonists, a hallmark of endotoxin tolerance. Also, it induces global dampening of the STAT response to cytokines across all cell types; splenocytes from challenged mice poorly respond to cytokine stimulation. Cytokines secreted by antigen presenting cells act on bystander cells and induced negative feedback, including SOCS expression and receptor endocytosis that prevent further STAT activation. Thus, bacterial recognition causes host immune activation followed by subsequent suppression of signaling. The work in chapter 3 transitions to a model of chronic infection with pathogenic Salmonella typhimurium. In addition to examining the innate response, this model enables investigation of adaptive immunity by monitoring the activation of T cells, their cytokine response profile, and TH-biasing by the transcription factors they express and cytokines they produce. During chronic infection, B cells and effector T cells undergo expansion but not contraction over the first 30 days, demonstrating that the immune system establishes a new equilibrium. However, the degree of cell expansion, as well as the ability of these cells to respond to cytokine, is quite variable across mice. These mice also have varied levels of bacterial burden, and the shape of the immune response denotes disease severity. High bacterial load is associated with trademarks of innate immunity such as elevated neutrophil numbers, serum cytokine levels, and the dampened STAT signaling observed during bacterial challenge in chapter 2. In contrast, the mice that control infection are enriched for markers of adaptive T cell immunity: high numbers of TH1 effector T cells, T cell proliferation, ability to respond to cytokines, and fewer regulatory T cells. Therefore, a strong adaptive response is correlated with containing the infection, while an innate response is indicative of high bacterial levels. This thesis concludes in chapter 4, with a discussion of how the findings fit in the context of cell signaling in other disease states. Leukemia and lymphomas, diseases of uncontained cell growth, are characterized by hyperactive cell signaling. In contrast, an activated immune response, such as during auto-immunity or in cancer infiltrating T cells, is marked by repressed ability to respond to cytokines. As inhibited cytokine responses were also observed during bacterial challenge and during severe chronic infection, it appears that a commonality amongst disease that activate an immune response is negative feedback to dampen further signaling and restrict inflammation.
- 2013 SpringerG. Singh Chhatwal, editor.Streptococci are Gram-positive bacteria that cause a wide spectrum of diseases, such as pharyngitis, necrotizing fasciitis and streptococcal toxic shock syndrome, as well as rheumatic fever and rheumatic heart disease as sequelae. Antibiotics alone have not been able to control the disease and in spite of many efforts an effective vaccine is not yet available. A prerequisite for novel and successful strategies for combating these bacteria is a complete understanding of the highly complex pathogenic mechanisms involved, which are analyzed in this volume. In ten chapters, prominent authors cover various aspects including streptococcal diseases and global burden, epidemiology, adaptation and transmission, and molecular mechanisms of different diseases, as well as sequelae, vaccine development and clinical management. This book will serve as a valuable reference work for scientists, students, clinicians and public health workers and provide new approaches to meeting the challenge of streptococcal diseases.
- 2008 Springereditors, Adam Finn, Andrew J. Pollard.
- 2013 SpringerNigel Curtis, Adam Finn, Andrew J. Pollard, editors.Also available: Print – 2013
- 2009 SpringerAdam Finn, Nigel Curtis, Andrew J. Pollard, editors.Shiga-toxin producing escherichia coli and the hemolytic uremic syndrome / Christina K. Ahn, Nicholas J. Holt, Phillip I. Tarr -- Global epidemiology of pneumococcal disease - new prospects for vaccine control / Vinicius C. Antao, William P. Hausdorff -- Current concepts of the pathogenesis of RSV bronchiolitis / Louis Bont -- How can we eradicate pertussis / James D. Cherry -- Recognition and management of encephalitis in children / James D. Cherry -- Microbiology and management of pleural empyema / Julia Clark -- Pneumococcal conjugate vaccines probe studies / Ron Dagan -- New findings in primary immunodeficiency / Andrew R. Gennery, Andrew J. Cant -- Routine use of influenza vaccine / David Isaacs -- Challenges in the evaluation and management of bone and joint infections and the role of new antibiotics for gram positive infections / Sheldon L. Kaplan -- Significance of serotype replacement for pneumococcal disease and antibiotic resistance / Keith P. Klugman -- Childhood intra-thoracic tuberculosis / Ben J. Marais -- Antibiotic pipeline in pediatrics / George H. McCracken -- Paediatric drug development and clinical trials / E. David G. McIntosh -- Influenza in pregnancy / Shelly McNeil, Beth Halperin, Noni MacDonald -- Febrile neutropenia in children with cancer / Stéphane Paulus, Simon Dobson -- PANDAS syndrome / Michael E. Pichichero -- Fever in the returned paediatric traveller / F. Andrew I. Riordan -- Molecular diagnostics of primary immunodeficiencies / Mirjam van der Burg, Menno C. van Zelm, Jacques J.M. van Dongen -- Human genetic resistance to malaria / Thomas N. Williams.
- 2010 SpringerAdam Finn, Nigel Curtis, Andrew J. Pollard, editors.
- 2011 SpringerNigel Curtis, Adam Finn, Andrew J. Pollard, editors.The value of vaccination / David E. Bloom -- Recent trends in global immunisation / Gustav J.V. Nossal -- New advances in typhoid fever vaccination strategies / Zulfiqar A. Bhutta ... [et al.] -- Prevention of vertical transmission of HIV in resource-limited countries / Catherine M. Wilfert ... [et al.] -- Pneumonia in children in developing countries / Frank Shann -- Darwin, microbes and evolution by natural selection / E. Richard Moxon -- Human herpesvirus 6 / Charles G. Prober -- Advances in the diagnosis and management of central venous access device infections in children / Asha Bowen and Jonathan Carapetis -- Moraxella catarrhalis-pathogen or commensal? / Christoph Aebi -- Anaerobic infections in children / Itzhak Brook -- Encephalitis diagnosis and management in the real world / Sarah S. Long -- Toxic shock syndrome-evolution of an emerging disease / James K. Todd -- Dissection of B-cell development to unravel defects in patients with a primary antibody deficiency / Mirjam van der Burg ... [et al.] -- Mumps is back : why is mumps eradication not working? / Noni Macdonald ... [et al.] -- Neonatal herpes simplex virus infections: where are we now? / Clara Thompson and Richard Whitley -- Rational approach to pediatric antifungal therapy / William J. Steinbach -- Antiviral therapy of CMV disease in children / Mike Sharland ... [et al.] -- Infectious hazards from pets and domestic animals / Mona Al-Dabbagh and Simon Dobson -- Novel technology to study co-evolution of humans and Staphylococcus aureus: consequences for interpreting the biology of colonisation and infection / Alex van Belkum -- A practical approach to eosinophilia in a child arriving or returning from the tropics / Penelope Bryant and Nigel Curtis.
- 2011 SpringerNigel Curtis, Adam Finn, Andrew J. Pollard, editors.Our Time of Pestilence: Purchasing Immunity and Ignoring the Misery of Others / Philip Alcabes -- Neonatal Meningitis: Can We Do Better? / Paul T. Heath, Ifeanyichukwu O. Okike and Clarissa Oeser -- Approaches Towards Avoiding Lifelong Antiretroviral Therapy in Paediatric HIV Infection / Philip J. R. Goulder and Andrew J. Prendergast -- How Short Is Long Enough for Treatment of Bone and Joint Infection? / Markus Pääkkönen and Heikki Peltola -- What's New in Diagnostic Testing and Treatment Approaches for Mycoplasma pneumoniae Infections in Children? / Ken B. Waites -- Pigs, Poultry, and Pandemic Influenza: How Zoonotic Pathogens Threaten Human Health / Thijs Kuiken, Ron Fouchier, Guus Rimmelzwaan, Judith van den Brand and Debby van Riel, et al. -- Kingella kingae Infections in Children: An Update / Inbal Weiss-Salz and Pablo Yagupsky -- Influenza Pandemics / Ruth Elderfield and Wendy Barclay -- Management of Shunt Related Infections / Mona Al-Dabbagh and Simon Dobson -- Nontuberculous Lymphadenopathy in Children: Using the Evidence to Plan Optimal Management / Julia E. Clark -- Pediatric Brucellosis: An (Almost) Forgotten Disease / Pablo Yagupsky -- Q Fever: Still More Queries than Answers / Corine E. Delsing, Adilia Warris and Chantal P. Bleeker-Rovers -- Rickettsioses in Children: A Clinical Approach / Emmanouil Galanakis and Maria Bitsori -- What is the Evidence Behind Recommendations for Infection Control? / Christina Gagliardo and Lisa Saiman -- What Do We Know About How to Treat Tuberculosis? / Ben J. Marais -- Bacterial Meningitis in Childhood / Manish Sadarangani and Andrew J. Pollard -- Mycobacterium marinum Infection / Marc Tebruegge and Nigel Curtis.
- 2014 SpringerWilliam Horsnell, editor."Helminth infections are common, cause considerable pathology, and alter a host's immune profile. This can have important consequences not only on the host's ability to control a helminth infection, but also on their ability to control unrelated infections. In endemic areas, understanding how helminth infection influences the outcome of common infectious diseases and changes the efficacy of childhood vaccination programs is an important public health question. This book reviews how host immunity to helminths alters our ability to respond to the major pathogens that exist in helminth endemic regions. Current understanding of how helminths alter important but relatively neglected contributors to the host's anti-helminth immune responses are addressed, namely host antibody responses and how maternal infection may alter a child's immune development. These are discussed in relation to the control of helminth infection and unrelated infections. Also covered are how helminth infections alter the host's ability to control TB, HIV and malarial infections along with neglected bacterial infections, such as cholera, and how endemic helminth infections are likely to alter our ability to respond to life-saving vaccination strategies"--Publisher's description.Also available: Print – 2014
- 2008 SpringerDaisuke Kitamura, editor.Recognition of pathogens: toll-like receptors / Satoshi Uematsu, Shizuo Akira -- Strategies of natural killer (NK) cell recognition and their roles in tumor immunosurveillance / C. Andrew Stewart, Eric Vivier -- Recent progress on paired immunoglobulin-like receptors / Hiromi Kubagawa ... [et al.] -- Self-nonself recognition through B-cell antigen receptor / Daisuke Kitamura -- How do T cells discriminate self from nonself? / Catherine Mazza, Bernard Malissen -- Fc receptors / Falk Nimmerjahn, Jeffrey V. Ravetch -- Self and nonself recognition by coreceptors on B lymphocytes: regulation of B lymphocytes by CD19, CD21, CD22, and CD72 / Kozo Watanabe, Takeshi Tsubata -- Co-receptors in the positive and negative regulation of T-cell immunity / Helga Schneider, Christopher E. Rudd.
- 2016Lauren Sompayrac.1. An overview -- 2. The innate immune system -- 3. B cells and antibodies -- 4. The magic of antigen presentation -- 5. T cell activation -- 6. T cells at work -- 7. Secondary lymphoid organs and lymphocyte trafficking -- 8. Restraining the immune system -- 9. Self tolerance and MHC restriction -- 10. Immunological memory -- 11. The intestinal immune system -- 12. Vaccines -- 13. The immune system gone wrong -- 14. Immunodeficiency -- 15. Cancer and the immune system.
- 2013Anna Poukchanski.Toxoplasma gondii is an obligate intracellular parasite. It has extraordinary abilities to infect virtually any warm blooded animal, cross a number of biological barriers (intestine, placenta and blood-brain), and invade any nucleated cell tested thus far in vitro. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to invade the host cell. Emphasis is placed on biological barriers and molecular mechanism of invasion for the different forms of the parasite. Chapter 2 describes a study of how Toxoplasma crosses the human placenta. Chapter 3 provides an insight as to how Enteric Glial Cells contribute to oral Toxoplasma infection in vivo. Chapter 4 deals with the study of how Toxoplasma sporozoites invade host cells. All research topics shed light on details of how Toxoplasma crosses the anatomical barriers: from the tissue barriers of placenta to infection to the possible immune and barrier functions of Enteric Glial Cells to how Toxoplasma sporozoites invade host cells. Chapter 2 describes experiments demonstrating that Toxoplasma tachyzoites invade the human placenta. These experiments used the human placental explant system to determine where the tachyzoites first invade, how they travel down the anchoring villi, and whether there exist type differences in ability to invade this tissue. This study provided several insights: (i) Toxoplasma tachyzoites are unable to penetrate the syncytium, and invade only the exposed tissue (anchoring villi); (ii) There does not appear to be a significant difference in the ability of different strains to infect the tissue. Chapter 3 addresses the possible role of TGF-[beta] by Enteric Glial Cells (EGCs) in oral Toxoplasma infection. Mice expressing a Dominant Negative TGF-[beta] receptor in EGCs were orally infected with Toxoplasma tissue cysts. At the end of the time trials, mice were sacrificed and their intestines subjected to histological analysis. Experiments did not reveal a clear-cut contribution to the control of inflammation by this cell type to the progress of disease. Chapter 4 examines the function of two paralogues of AMA1 and RON2 that are present exclusively in Toxoplasma sporozoites. Dubbed sporoAMA1 and sporoRON2, respectively, that sporoRON2 and sporoAMA1 form an exclusive pairing, stabilized with unique structural features. Furthermore, pre-treating sporozoites with a C-terminal portion of sporoRON2 (but not generic RON2) inhibits sporozoite invasion. We see sporoRON2 in a different compartment from RON4, suggesting that sporoRON2 functions independently of known moving junction components. These data indicate that sporozoites' host cell invasion is dependent on a novel, stage-specific version of the AMA1-RON2 pairing.
- 2016 SpringerGraham Hughes.1. Sticky blood: the disease is common -- 2. Main clinical features -- 3. Clotting in veins -- 4. Stroke -- 5. Memory loss and "Alzheimers" -- 6. Headaches, migraine and fits -- 7. The spinal cord and "multiple sclerosis" -- 8. The heart and arteries -- 9. Other organs -- 10. The "catastrophic" antiphospholipid syndrome -- 11. Pregnancy and fetal loss -- 12. Hughes' syndrome and lupus -- 13. Treatment -- 14. The outlook -- 15. What blood tests do we use? -- 16. Research -- 17. Background -- 18. An update -- 19. Further reading and websites -- Index.
- 2006 SpringerM.A. Khamashta (ed.).
- 2013 Springerby Graham Hughes, Munther A. Khamashta.Hughes Syndrome: Highways and Byways is a handy and easy-to-read guide to the main features of Hughes syndrome. There has been worldwide interest in this 'new' syndrome (first described in 1983). A clotting tendency which can potentially affect any organ in the body, it is: responsible for 1 in 5 recurrent miscarriages (now successfully treated with aspirin and heparin) responsible for 1 in 5 young (under 45) strokes a major cause of early heart attacks responsible for 1 in 5 deep vein thromboses an important cause of migraine.
- 2008 SpringerScott K. Dessain, editor.Therapeutic control of hepatitis C virus: the role of neutralizing monoclonal antibodies / Z. Y. Keck ... [et al.] -- Antibodies for HIV treatment and prevention: window of opportunity? / M. Huber ... [et al.] -- Human monoclonal antibody and vaccine approaches to prevent human rabies / T. Nagarajan ... [et al.] -- Immunoprophylaxis of RSV infection: advancing from RSV-IGIV to palivizumab and motavizumab / H. Wu ... [et al.] -- The molecular basis of antibody protection against West Nile virus / E. Mehlhop ... [et al.] -- Exploring the native human antibody repertoire to create antiviral therapeutics / S. K. Dessain ... [et al.].
- 2014 Springer Protocolsedited by Michael Steinitz.Human monoclonal antibodies : the residual challenge of antibody immunogenicity / Herman Waldmann -- Technical and ethical limitations in making human monoclonal antibodies (an overview) / Mark C. Glassy and Rishab Gupta -- Therapeutic human monoclonal antibodies in inflammatory diseases / Sotirios Kotsovilis and Evangelos Andreakos -- Therapeutic human monoclonal antibodies against cancer / Jamie Jarboe, Anumeha Gupta, and Wasif Saif -- Polyclonal and monoclonal antibodies in clinic / Bharath Wootla, Aleksandar Denic, and Moses Rodriguez -- Production of human monoclonal Antibodies by the Epstein-Barr virus method / Michael Steinitz -- Humanization and simultaneous optimization of monoclonal antibody / T. Kuramochi, T. Igawa, H. Tsunoda, and K. Hattori -- Chimeric Antibodies / Kohei Kurosawa, Waka Lin, and Kunihiro Ohta -- Recombinant genetic libraries and human monoclonal antibodies / Jarrett J. Adams, Bryce Nelson, and Sachdev S. Sidhu -- Production of stabilized scFv antibody fragments in the E. coli bacterial cytoplasm / Lilach Vaks and Itai Benhar -- Construction and production of an IgG-like tetravalent bispecific antibody, IgG-single-chain Fv fusion / Dan Lu and Zhenping Zhu -- Construction of human antibody gene libraries and selection of antibodies by phage display / André Frenzel [and others] -- Antigen-specific human monoclonal antibodies from transgenic mice / Susana Magadán Mompó and África González-Fernández -- Phage display technology for human monoclonal antibodies / Cecilia Deantonio [and others] -- Antigen-specific in vitro immunization : a source for human monoclonal antibodies / Kosuke Tomimatsu and Sanetaka Shirahata -- Methods for radiolabelling of monoclonal antibodies / Vladimir Tolmachev, Anna Orlova, and Karl Andersson -- Purification of human monoclonal antibodies and their fragments / Thomas Müller-Späth and Massimo Morbidelli -- Idiotype-specific intravenous immunoglobulin (IVIG) for therapy of autoimmune diseases / Miri Blank, Tomer Bashi, and Yehuda Shoenfeld.
- 2011 Future Mededitor, Eduardo L. Franco.Human papillomavirus vaccines / Eduardo L. Franco -- Pathobiology and immunology of human papillomavirus / Margaret Stanley -- Overview of clinical evidence : the quadrivalent vaccine Gardasil / Suzanne M Garland -- Overview of clinical evidence : Cervarix -- Tino F. Schwarz -- HPV vaccines : public health and clinical guidelines / F. Xavier Bosch -- Perspectives for prophylactic and therapeutic vaccination for HPV-induced lesions / Shreya Kanodia & W. Martin Kast.
- 2014 Springer Protocolsedited by Elisa Vicenzi and Guido Poli.Virion attachment and entry : HIV gp120 env biotinylation, gp120 env, or integrin ligand-binding assay / Claudia Cicala and James Arthos -- CryoEM analysis of capsid assembly and structural changes upon interactions with a host restriction factor, TRIM5[alpha] / Gongpu Zhao and Peijun Zhang -- The fate of HIV-1 capsid : a biochemical assay for HIV-1 uncoating / Yang Yang, Jeremy Luban, and Felipe Diaz-Griffero -- The cyclosporin A washout assay to detect HIV-1 uncoating in infected cells / Amy E. Hulme and Thomas J. Hope -- Imaging HIV-1 nuclear pre-integration complexes / Anna Cereseto and Mauro Giacca -- HIV-1 reverse transcription / Andrea Cimarelli and Jean-Luc Darlix -- RNase H : specificity mechanisms of action, and antiviral target / Karin Moelling, Felix Broecker, and John E. Kerrigan -- HIV-1 chromatin, transcription, and the regulatory protein Tat / Laurence Colin, Eric Verdin, and Carine Van Lint -- HIV-1 Rev function and RNA nuclear-cytoplasmic export / Alan Cochrane -- HIV-1 accessory proteins : Nef / Anke Heigele [and three others] -- HIV-1 accessory proteins : VpR / Richard Y. Zho and Michael I. Bukrinsky -- HIV-1 accessory proteins : Vpu and Vif / Amy Andrew and Klaus Strebel -- SIVSM/HIV-2 Vpx proteins : function and uses in the infection of primary myeloid cells / Gregory Berger and Andrea Cimarelli -- Imaging of HIV assembly and release / Barbara Müller and Jacomine Krijnse-Locker -- HIV-1 isolation from infected peripheral blood mononuclear cells / Stefania Dispinseri [and four others] -- Determination of HIV-1 co-receptor usage / Mariangela Cavarelli and Gabriella Scarlatti -- The macrophage and HIV : basic concepts and methodologies / Suzanne Gartner -- HIV infection of dendritic cells / Najla Nasr [and three others] -- Histocultures (tissue explants) in human retrovirology / Anush Arakelyan [and four others] -- Single-copy quantification of HIV-1 in clinical samples / Ann Wiegand and Frank Maldarelli -- Quantification of total HIV1-DNA in peripheral blood mononuclear cells / Christine Rouzioux, Adeline Mélard, and Véronique Avéttand-Fénoël -- HIV-1 based lentiviral vectors / Ying Poi Liu and Ben Berkhout -- Quantification of miRNA by poly(A)-RT-qPCR arrays and verification of target sites in HIV-1 using a one-LTR infectious molecular clone / Zachary A. Klase, Laurent Houzet, and Kuan-Teh Jeang -- Investigating human T cell lymphotropic retrovirus (HTLV) Tax function with molecular and immunophenotypic techniques / Greta Forlani, Roberto S. Accolla, and Giovanna Tosi -- Proviral load determination of HTLV-1 and HTLV-2 in patients' peripheral blood mononuclear cells by real-time PCR / Claudio Casoli, Elisabetta Pilotti, and Umberto Bertazzoni -- Quantitative analysis of human T-lymphotropic virus type 1 (HTLV-1) gene expression using nucleo-cytoplasmic fractionation and splice junction-specific real-time RT-PCR (qRT-PCR) / Ilaria Cavallari, Francesca Rende, and Vincenzo Ciminale.
- 2009 SpringerGraham A.W. Rook, editor.
- 2008 ScienceDirectvolume editors, Adriana del Rey, George P. Chrousos, Hugo O. Besedovsky.
- 2012 SpringerK.D. Rainsford.Ibuprofen is one of the most successful drugs used worldwide for the treatment of mild to moderate pain and various inflammatory conditions, even in a low-dose form for over-the-counter (OTC), non-prescription sale. Over the past 40 years, ibuprofen has been proven to be as safe or safer and just as effective as established non-steroidal anti-inflammatory drugs (NSAIDs) or coxibs. This book reviews the pharmacology, clinical uses and adverse effects of ibuprofen. Its disposition and unique modes of action in relation to clinical effects are discussed as well as various formulations and the impact of food and other variables on its actions and gastro-intestinal safety. The use of combinations of ibuprofen with other drugs (e.g. paracetamol, codeine and caffeine) are critically assessed. There are already some indications of potential therapeutic benefits of the drug combinations in treating certain painful conditions, while still retaining the relative safety benefits of ibuprofen (at least at OTC dosages). The impact of natural products and Chinese Medicines on the safety of ibuprofen is also reviewed. The book is written in a more general style, including explanatory diagrams, for anyone interested in the properties, actions and uses of ibuprofen.
- 2015 SpringerJuan J. Lafaille, Maria A. Curotto de Lafaille, editors.Biology of IgE production: IgE cell differentiation and the memory of IgE responses / Jin-Shu He, Sriram Narayanan, Sharrada Subramaniam, Wen Qi Ho, Juan J. Lafaille and Maria A. Curotto de Lafaille -- Molecular mechanisms of IgE class switch recombination / Pei Tong and Duane R. Wesemann -- Anti-IgE therapy: clinical utility and mechanistic insights / Stephanie L. Logsdon and Hans C. Oettgen -- New insights on the signaling and function of the high-affinity receptor for IgE / Ryo Suzuki, Jörg Scheffel and Juan Rivera -- Helminth-induced IgE and protection against allergic disorders / Firdaus Hamid, Abena S. Amoah, Ronald van Ree and Maria Yazdanbakhsh -- IgE immunotherapy against cancer / Lai Sum Leoh, Tracy R. Daniels-Wells and Manuel L. Penichet -- Index.
- 2014 SpringerHisanori Umehara, Kazuichi Okazaki, John H. Stone, Shigeyuki Kawa, Mitsuhiro Kawano, editors.IgG4-related disease is a new systemic disease that has only recently been identified and characterized. However, most clinical practitioners are not yet familiar with it and thus are likely to misdiagnose it. The purpose of this book is to raise awareness of this disease and its diagnostic pitfalls. A wealth of radiological and histopathological images helps clinicians to understand its characteristics in various organs as well as their clinical and basic medical backgrounds. All of the authors are experts who have published numerous important papers in the field. This book will be useful to physicians in various disciplines such as gastroenterology, rheumatology, ophthalmology, otolaryngology, urology, hematology, and respiratory medicine, not only as a textbook but as an authoritative and comprehensive reference work as well.
- 2013 SpringerValérie Quesniaux, Bernhard Ryffel, Franco Di Padova, editors.The knowledge of Th17 cells and other cell populations which secrete IL-17A, and/or IL-22 has expanded tremendously since the publication of the first edition "Th17 Cells: Role in Inflammation and Autoimmune Disease" in 2008. The present volume has been completely revised with the addition of new chapters on the IL-17 receptor family and signaling, and an in-depth review of IL-22 and innate lymphoid cells. The differentiation of naïve T cells into regulatory T cells and Th17 cells as well as the plasticity of Th17 cells is discussed.Also available: Print – 2013
- 2009 CRCnetBASEJulius M. Cruse, Robert E. Lewis.
- 2011 CRCnetBASEMichael A. Alexander.Which cells control the anti-cancer T cell immune response? -- Antigen presentation -- T cells and cancer cells : components of immune-based anti-cancer therapy -- Anti-cancer vaccines : new approaches -- How and why do we get cancer and can immune-based anti-cancer therapy save us? -- Immunotherapeutic approaches to the treatment of leukemia -- Cancer-induced autoimmunity -- Can we solve the cancer stem cell program and cure cancer using T cell-based immunotherapy? -- Translational immunology and its impact on anti-cancer T cell immunity and the development of immunotherapeutic treatments for cancer -- Dendritic cells, immunotherapy, and the anti-cancer T cell response -- Regulatory T cells, dendritic cells, and the success of immunotherapeutic treatments for cancer -- NK cells and their role in the development of immune-based anti-cancer therapy -- How cancer cells influence the anti-cancer T cell imune response and why this is a problem during the immunotherapeutic treatment of cancer -- The T cell anti-cancer response, T cell regulation, and immunotherapy of neural crest cancers -- The immunological hole : will we fall in?
- 2011Adrianne Elizabeth (Hughes) Vasey.Allogeneic hematopoietic cell transplantation (HCT) is an excellent model for the controlled study of adoptively transferred cells in the induction and progression of numerous immune responses in vivo, with the added benefit that these cells can be tracked, identified, and re-isolated. Using this model, we conducted four distinct sets of studies related to the trafficking and function of immune cells in allogeneic responses. In our first project, we focused on the early events of T cell activation leading to the induction of Graft-versus-Host Diesease (GVHD) in a murine model of major histocompatibility complex (MHC)-matched transplantation. Although it is well known GVHD occurs in MHC-matched transplants, little is known about donor T cell activation kinetics in minor-mismatched models. Yet, because these models better approximate clinical transplantation, it is critical to understand how GVHD develops across minor barriers. To investigate temporal and spatial events of GHVD development, side-by-side transplants were conducted into major and minor-mismatched recipients using hematopoietic cells from the same donor mouse strain. In both models, T cells home to nodal sites by day 3, proliferate, and exit to GVHD target tissues by day 6. Additionally, expression of homing and activation markers was equivalent for all markers examined on day 3. However, tissue migration and proliferation were reduced in the minor model. And by day 6, minor-mismatched T cells had increased CD62L retention and reduced P-selectin and CD44 expression. We also found fewer MHC-matched T cells producing interferon-[gamma] (IFN-[gamma]) and tumor necrosis factor-[alpha] (TNF-[alpha]). Our data show that very early events of donor T cell activation are similar in both models, suggesting that delays in GVHD onset across minor barriers arise from temporal differences in the effector phase, rather than the initiation phase, of GVHD. For our second project, we examined the ability of transplanted natural killer (NK) cells to impact GVHD in MHC-matched transplants as allogeneic NK cells are already known to suppress GVHD in transplants across major histocompatibility barriers. Since NK cells can lyse host antigen-presenting cells (APCs) in these transplants due to disparities in MHC class I expression between the recipient and donor, thus reducing the activation of donor T cells, it is thought that this is primary mechanism of NK-mediated reductions in GVHD. However, in MHC-matched transplants, MHC class I expression is shared between donor and host, protecting host APCs from lysis. Previous work from our laboratory has shown that NK cells can also reduce GVHD, in MHC-mismatched transplants, through the inhibition and lysis of autologous donor T cells that have upregulated expression of NKG2D activating ligands. As such, we wondered whether this mechanism may also reduce GVHD in transplants across minor histocompatibility barriers. Our data demonstrate that donor NK cells are able to improve survival and reduce GHVD disease severity in the more clinically relevant model of MHC-matched transplantation. As allorecognition and lysis of MHC-mismatched host APCs is not possible in this model, NK cells must be mediating their benefits through alternate mechanisms. Although we did find that NK cells were capable of reducing the proliferation of syngeneic T cells in an MLR using irradiated MHC-matched splenocytes as stimulators, we were unable to find evidence for the direct inhibition, or lysis, of donor T cells by NK cells in vivo. It seems likely that this was at least partially due to the much lower number of NK cells used in these studies compared to the previous reports. Additionally, as NK cells may impact T cells that are homeostatically proliferating differently then they impact T cells proliferating in response to antigen, it will be critical for future studies to clearly separate these two populations, especially given the reduced frequency of alloreactive T cells in MHC-matched models. Perhaps then we will be able to identify the mechanisms of donor NK mediated reductions in GVHD. In our third project, we studied the in vivo ability of NK cells to clear tumor. NK cells have natural cytotoxicity and cytokine production capabilities, and are known to mount potent responses against both viruses and tumor cells. Preclinical data in combination with results from clinical trials of haploidentical killer immunoglobulin-like receptor (KIR)-ligand mismatched bone marrow transplantation led to interest in the use of adoptive NK immunotherapy for the treatment of malignancy. Recent early-phase clinical trial results have shown that allogeneic NK cells can be safely administered after chemotherapy and/or irradiation but have also demonstrated limited persistence of the infused NK cells. Additionally, in the absence of control arms, it has been difficult to determine whether tumor clearance is due to the preparative regimen, or due to actual immune mediated effects. Here, using several murine models of NK-sensitive hematologic malignancy, we trace the fate of adoptively infused NK cells and show that NK cells traffic to tumor sites but fail to control tumor growth. NK cells rapidly down-regulate effector functions and activating receptor expression upon homeostatic proliferation and upon tumor exposure in syngeneic as well as allogeneic settings. This dysfunction is likely cell-intrinsic as it is accompanied by down-regulation of the canonical transcription factors Eomesodermin and T-bet, and is not impacted by depletion of regulatory T cells from the tumor milieu. These results demonstrate that NK cell capability is intrinsically limited and cannot be relied upon for adoptive anti-tumor immunotherapy. As such, novel approaches may be required in order to circumvent the described dysfunction phenotype. Lastly, we attempted to deplete dendritic cells (DCs) within the host to study impacts on the development of GVHD. To try to delineate whether there is a critical time window during which host DCs cells need to initiate GVHD, we conducted MHC-mismatched transplants into BALB/c mice that were chimeric for the CD11c DTR-GFP transgene in their hematopoietic system, to be able to control the deletion of host DCs at specific time points. Despite initial problems with DT lethality in the original transgenic mice, we were able to achieve successful, transient, depletion of host DCs using these chimeric mice made from the BM of transgenic donors. Although we found that DT treatment of transgenic mice 24 hours to harvesting their spleens for use as stimulators in an MLR greatly reduced allogeneic T cell proliferation, DT treatment of transgenic chimeric recipients prior to irradiation and transplantation with allogeneic T cells did not provide any protection from the development of GVHD, even with up to a 4 day delay in T cell administration and titrating T cell doses down to 1 x 105. In contrast, DT treated mice actually had reduced survival compared to transgenic chimeras given only PBS, suggesting that DC depletion may somehow enhance T cell proliferation. This may be partially due to negative impacts on the activation, expansion, and function of Tregs, which are known to have important cross-talk with DCs. These studies were further complicated by the fact that the chimeric transgenic mice had all previously undergone lethal TBI, as we found that previously irradiated recipients had reduced survival when transplanted with allogeneic T cells, regardless of whether or not they were transgenic of WT or whether they received DT or PBS, compared to mice that had never been irradiated previously. Additionally, since DC depletion is not 100% in these animals, we were unable to precisely determine the contribution of remaining cell types in the outcomes we observed. As such we were unable to conclude anything about the role of host DCs in the development of GVHD from these studies.
- 2013 Springer Protocolsedited by Andrew L. Snow, Michael J. Lenardo.Quantitating lymphocyte programmed cell death in vitro using simple kill assays / Lixin Zheng -- Fluorescence-activated cell sorting-based quantitation of T cell receptor restimulation-induced cell death in activated, primary human T cells / Gil Katz and Andrew L. Snow -- Evaluation of IL-2-withdrawal-induced apoptosis in human T lymphocytes / Joao Bosco Oliveira -- Determination of apoptosis sensitivity in specific T cell subsets from human peripheral blood by utilizing a multiparameter fluorescence-activated cell sorting-based technique / Bernice Lo and Madhu Ramaswamy -- Visualization of fas-mediated death-inducing signaling complex formation by immunoprecipitation / Nelia Cordeiro and Nicolas Bidere -- Analyses of programmed cell death in dendritic cells / Min Chen, Lily Huang, and Jin Wang -- Detection of necrosis by release of lactate dehydrogenase Activity / Francis Ka-Ming Chan, Kenta Moriwaki, and Maria Jose De Rosa -- Assessment of CD4+ and CD8+ T cell responses using MHC class I and II tetramers / Sema Kurtulus and David Hildeman -- Homeostatic proliferation of mature T cells / Christopher E. Martin [and others] -- Quantitating lymphocyte homeostasis in vivo in humans using stable isotope tracers / Liset Westera [and others] -- Real-time quantitative (RQ- )PCR approach to quantify the contribution of proliferation to B lymphocyte homeostasis / Menno C. van Zelm [and others] -- Molecular measurement of T cell receptor excision circles / Heather E. Lynch and Gregory D. Sempowski -- Isolation of RNA and the synthesis and amplification of cDNA from antigen-specific T cells for genome-wide expression analysis / R. Anthony Barnitz [and others] -- Designs for massively parallel sequencing approaches to identify causal mutations in human immune disorders / Yu Zhang and Helen C. Su -- Flow cytometric measurement of SLAM-associated protein and x-linked inhibitor of apoptosis / Rebecca A. Marsh, Jack J. Bleesing, and Alexandra H. Filipovich -- In vitro suppression assay for functional assessment of human regulatory T cells / Dat Q. Tran.
- 2009 SpringerWalter K.H. Krause, Rajesh K. Naz, [editors].
- 2006 Springeredited by Richard S. Blumberg, Markus F. Neurath.Structure and function of the gut mucosal immune system / Reinhard Pabst and Hermann J. Rothkutter -- Functional aspects of the mucosal immune system / Cathryn Nagler-Anderson -- Recent progress in inflammatory bowel disease genetics / Judy H. Cho -- Microbial and dietary factors in the pathogenesis of chronic, immune-mediated intestinal inflammation / R. Balfour Sartor -- Experimental models of mucosal inflammation / Warren Strober and Ivan J. Fuss -- Overview of role of the immune system in the pathogenesis of inflammatory bowel disease / Thomas T. MacDonald and Giovanni Monteleone -- The role of the epithelial barrier in inflammatory bowel disease / Edward E.S. Nieuwenhuis and Richard S. Blumberg -- Involvement of dendritic cells in the pathogenesis of inflammatory bowel disease / Francisco Leon ... [et al.] -- Alterations of T lymphocytes in inflammatory bowel diseases / Charles O. Elson, Yingzi Cong and Casey T. Weaver -- The B-cell system in inflammatory bowel disease / Per Brandtzaeg, Hege S. Carlsen and Trond S. Halstensen -- Alterations of mesenchymal and endothelial cells in inflammatory bowel diseases / Claudio Fiocchi ... [et al.] -- Role of mast cells and eosinophils in neuroimmune interactions regulating mucosal inflammation in inflammatory bowel disease / Stephan C. Bischoff and Thomas Gebhardt -- Multiparameter analysis of immunogenetic mechanisms in clinical diagnosis and management of inflammatory bowel disease / Jonathan Braun and Stephan R. Targan -- The role of probiotics and antibiotics in regulating mucosal inflammation / Rainer Duchmann -- From immunogenic mechanisms to novel therapeutic approaches in inflammatory bowel disease / Martin H. Holtmann and Markus F. Neurath.
- 2007 Springeredited by Michael R. Shurin, Yuri S. Smolkin.Also available: Print – 2007
- 2009. Kargervolume editors, R. Pourmand.Acute neuropathies / Bromberg, M.B. -- Chronic neuropathies : chronic inflammatory demyelinating neuropathy and its variants / Ramchandren, S., Lewis, R.A. -- Nonsystemic vasculitic neuropathy : update on diagnosis, classification, pathogenesis, and treatment / Collins, M.P., Periquet-Collins, I. -- Dysimmune neuropathy / Kwan, J.Y. -- Autoimmune autonomic ganglionopathy / Winston, N., Vernino, S. -- Myasthenia gravis with anti-acetylcholine receptor antibodies / Meriggioli, M.N. -- Muscle-specific receptor tyrosine kinase antibody-positive and seronegative myasthenia gravis / Muppidi, S., Wolfe, G.I. -- Lambert-Eaton myasthenic syndrome / Pourmand, R. -- Idiopathic inflammatory myopathies / Dimachkie, M.M., Barohn, R.J. -- Stiff person syndrome / Duddy, M.E., Baker, M.R.
- 2014 SpringerUwe Pleyer, Talin Barisani-asenbauer, Phuc Le Hoang, Narsing A. Rao, editors.These guidelines, compiled by a panel of clinicians and scientists with a high level of expertise, aim to provide readers with the most up-to-date and comprehensive instructions on the treatment and prevention of ocular inflammation. All of the recommendations are explicitly linked to supporting evidence and graded according to the strength of that evidence, and the editors have made every effort to ensure that chapters are of a consistently high methodological quality. The guidelines for each treatment include dose and the frequency and mode of delivery. Significant side-effects of treatment are identified and distinguished from those of the disease in question. Suggestions are presented for the prevention both of the disease itself and of the treatment-related complications. In addition, likely future directions in treatment and prevention are identified. These guidelines will be of great practical value for all clinicians and clinical scientists with an interest in the subject.
- 2007 Springeredited by Jingwu Zhang.
- 2006 ScienceDirectTak W. Mak and Mary E. Saunders ; contributors, Maya R. Chaddah, Wendy L. Tamminen.
- 2007 Kargervolume editors: Jerry Y. Niederkorn, Henry J. Kaplan.Also available: Print – 2007
- 2015 SpringerJohn D. Lambris, Kristina N. Ekdahl, Daniel Ricklin, Bo Nilsson, editors.1. Thromboinflammation in therapeutic medicine -- 2. Complement interactions with blood cells, endothelial cells and microvesicles in thrombotic and inflammatory conditions -- 3. Role of complement on broken surfaces after trauma -- 4. Complement involvement in periodontitis: molecular mechanisms and rational therapeutic approaches -- 5. The lectin pathway of complement and biocompatibility -- 6. Foreign body reaction to subcutaneous implants -- 7. Molecular characterization of macrophage-biomaterial interactions -- 8. Heparan sulfate proteoglycan metabolism and the fate of grafted tissues -- 9. Xenotransplantation of cells, tissues, organs and the Greman research foundation Transregio Collaborative Research Centre 127 -- 10. Macroencapsulated pig islets correct induced diabetes in primates up to 6 months -- 11. Regulation of instant blood mediated inflammatory reaction (IBMIR) in pancreatic islet xeno-transplantation: points for therapeutic interventions -- 12. Cell surface engineering for reguation of immune reactions in cell therapy -- 13. Complement interception across humoral incompatibility in solid organ transplantation: a clinical perspective -- Index.Also available: Print – 2015
- 2008 SpringerLuis Graca, editor.
- 2008 Springeredited by Michael Vajdy.
- 2013 Cold Spring Harb Lab Presssymposium organizers and proceedings editors Anne O'Garra, Michel Nussenzweig, Stephen Smale, and David Stewart and Bruce Stillman.Development and antigen receptor gene assembly: TET proteins and 5-methylcytosine oxidation in the immune system / Ageliki Tsagaratou, Anjana Rao ; Control of antigen receptor diversity through spatial regulation of V(D)J recombination / Anja Ebert, Jasna Medvedovic, Hiromi Tagoh, Tanja A. Schwickert, Meinrad Busslinger ; Establishment and maintenance of B cell identity / Rudolf Grosschedl ; Transcriptional establishment of cell-type identity : dynamics and causal mechanisms of T-cell lineage commitment / Ellen V. Rothenberg, Ameya Champhekar, Sagar Damle, Marissa Morales Del Real, Hao Yuan Kueh, Long Li, Mary A. Yui ; The epigenetics of early lymphocyte development / C. Murre -- Gene regulation: Regnase-1, a ribonuclease involved in the regulation of immune responses / Shizuo Akira ; Toward an understanding of the gene-specific and global logic of inducible gene transcription / Stephen T. Smale, Scott E. Plevy, Amy S. Weinmann, Liang Zhou, Vladimir R. Ramirez-Carrozzi, Scott D. Pope, Dev M. Bhatt, Ann-Jay Tong ; Tolerization of inflammatory gene expression / John J. Seeley, Sankar Ghosh -- The 'histone mimicry' by pathogens / Uwe Schaefer, Jessica S.Y. Ho, Rab K. Prinjha, Alexander Tarakhovsky -- Development and function of myeloid subsets: Myb-independent macrophages : a family of cells that develops with their tissue of residence and is involved in its homeostasis / Elisa Gomez Perdiguero, Frederic Geissmann ; The molecular choreography of IRF4 and IRF8 with immune system partners / Harinder Singh, Elke Glasmacher, Abraham B. Chang, Bryan Vander Lugt -- The IRF family transcription factors at the interface of innate and adaptive immune responses / Hiroaki Ikushima, Hideo Negishi, Tadatsugu Taniguchi -- T-cell differentiation and function: IL-1b strikingly enhances antigen-driven CD4 and CD8 t-cell responses / S.Z. Ben-Sasson, K. Wang, J. Cohen, W.E. Paul ; A modified model of t-cell differentiation based on mTOR activity and metabolism / Jonathan D. Powell, Emily B. Heikamp, Kristen N. Pollizzi, Adam T. Waickman ; Novel tools to dissect the dynamic regulation of TCR signaling by the kinase Csk and the Phosphatase CD45 / Ying Xim Tan, Julie Zikherman, Arthur Weiss -- NK cells and innate lymphoid cells: Dissection of signaling in inflammation : three novel inflammatory regulators / Thorsten Berger, Mary E. Saunders, Tak W. Mak ; Tissue-resident natural killer cells / Wayne M. Yokoyama, Dorothy K. Sojka, Hui Peng, Zhigang Tian -- Microbial immunity: Immunology taught by human genetics / Jean-Laurent Casanova, Laurent Abel, Lluis Quintana-Murci ; Systems approach to understand the immune response in tuberculosis : an iterative process between mouse models and human disease / Anne O'Garra ; The zebrafish guide to tuberculosis immunity and treatment / Lalita Ramakrishnan ; Microbiota : host interactions in mucosal homeostasis and systemic autoimmunity / Randy S. Longman, Yi Yang, Gretchen E. Diehl, Sangwon V. Kim, Dan R. Littman ; The promised land of human immunology / Laura F. Su, Arnold Han, Helen M. McGuire, David Furman, Evan W. Newell, Mark M. Davis -- Tolerance, TREGS, and inflammasome: Transcriptional control of regulatory t-cell differentiation / Joris van der Veeken, Aaron Arvey, Alexander Rudensky -- miR-181 and metabolic regulation in the immune system / Adam Williams, Jorge Henao-Mejia, Christian C.D. Harman, Richard A. Flavell ; Encoding immunological memory in the initiation of b-cell receptor signaling / Susan K. Pierce, Wanli Liu -- Tumor immunology and genome stability: Programmed cell death 1-directed immunotherapy for enhancing t-cell function / Koichi Araki, Ben Youngblood, Rafi Ahmed ; Immune surveillance of unhealthy cells by natural killer cells / Alexandre Iannello, David H. Raulet ; Studying Epstein-Barr virus pathologies and immune surveillance by reconstructing EBV infection in mice / Tomoharu Yasuda, Tristan Wirtz, Baochun Zhang, Thomas Wunderlich, Marc Schmidt-Supprian, Thomas Sommermann, Klaus Rajewsky -- Closing lecture: Pathogen-sensing, regulatory t cells, and responsiveness-tuning collectively regulate foreign- and self-antigen mediated t-cell responses / William E. Paul, Joshua D. Milner, Zvi Grossman.
- 2012 Wileyedited by Tracey Lamb.Introduction : Immunoparasitology : The making of a modern immunological science -- 1. Notes on the immune system -- 2. Introduction to Protozoan infections -- 3. Apicomplexa : Malaria -- 4. Apicomplexa : Toxoplasma gondii -- 5. Apicomplexa : Cryptosporidium -- 6. Diplomonadida : Giardia -- 7. Kinetoplastids : Leishmania -- 8. Kinetoplastids : Trypanosomes -- 9. Kinetoplastids : Trypanosoma cruzi (Chagas disease) -- 10. Introduction to Helminth infections -- 11. Nematoda : Filarial Nematodes -- 12. Nematoda : Ascaris lumbricoides -- 13. Nematoda : Hookworms -- 14. Nematoda : Trichuris -- 15. Nematoda : Trichinella -- 16. Trematoda : Schistosomes -- 17. Cestoda : Tapeworm infection -- 18. Co-infection : Immunological considerations -- 19. HIV and malaria co-infection -- 20. HIV and Leishmania co-infection -- 21. Gastrointestinal Nematodes and malaria -- 22. Malaria and Schistosomes -- 23. Hygiene and other early childhood influences on the subsequent function of the immune system -- 24. Nematodes as therapeutic organisms -- 25.1. Vaccination against malaria -- 25.2. Current approaches to the development of a vaccine against Leishmaniasis -- 25.3. Vaccination against Hookworms -- 25.4. Current approaches to the development of a vaccine against Filarial Nematodes.
- 2013 SpringerIgor Malyshev.A General Description of HSPs, The Molecular Structure of HSP70 and The HSP70 Cycle -- The Functions of HSP70 in Normal Cells -- HSP70 in Damaged Cells -- Mechanisms of Activation and Inactivation of HSP70 Synthesis -- HSP70 in the Immune Responses -- HSP70 in Carcinogenesis -- HSP70 in aging -- The role of HSP70 in the protection of: (A) The brain in alzheimer's disease and (B) The heart in cardiac surgery.
- 2015 WHOModule 1. Target diseases and vaccines -- Module 2. The vaccine cold chain -- Module 3. Ensuring safe injections -- Module 4. Microplanning for reaching every community -- Module 5. Managing an immunization session -- Module 6. Monitoring and surveillance -- Module 7. Partnering with communities.Also available: Print – 2015
- 2015 Kargervolume editors, Olivier Michielin, George Coukos.Immunotherapies in early and advanced renal cell cancer / Kasenda, B., Larkin, J., Gore, M. -- Immunotherapy of brain tumors / Dutoit, V., Migliorini, D., Walker, P.R., Dietrich, P.-Y. -- Immunotherapy of melanoma / Snyder, A., Zamarin, D., Wolchok, J.D. -- Immunotherapy of breast cancer / Criscitiello, C., Curigliano, G. -- Current developments in actively personalized cancer vaccination with a focus on RNA as the drug format / Diken, M., Kreiter, S., Kloke, B., Sahin, U. -- Immune checkpoint inhibitors / Haanen, J.B.A.G., Robert, C. -- Radiotherapy and immunotherapy : improving cancer treatment through synergy / Reynders, K., De Ruysscher, D. -- Combinations therapies / Reinmuth, N., Reck, M. -- Promise of immunotherapy in lung cancer / Shanker, A., Dikov, M.M., Carbone, D.P. -- T cell engineering / Pircher, M., Schirrmann, T., Petrausch, U.
- 2013 SpringerKumar Selvarajoo.Immuno Systems Biology aims to study the immune system in the more integrated manner on how cells and molecules participate at different system levels to the immune function. Through this book Kumar Selvarajoo introduces to physicists, chemists, computer scientists, biologists and immunologists the idea of an integrated approach to the understanding of mammalian immune system. Geared towards a researcher with limited immunological and computational analytical experience, the book provides a broad overview to the subject and some instruction in basic computational, theoretical and experimental approaches.
- 2007 CRCnetBASEedited by Jeanette M. van Emon.Integrating bioanalytical capability in an environmental analytical laboratory / Jeanette M. Van Emon ... [et al.] -- Directed evolution of ligand-binding proteins / K. Kramer, H. Geue, and B. Hock -- In vitro monoclonal antibody production: academic scale / Frances Weis-Garcia -- Antibodies to heavy metals: isolation, characterization, and incorporation into microplate-based assays and immunosensors / Diane A. Blake ... [et al.] -- Molecular imprinting for small molecules / Z. Cobb and L. I. Andersson -- Aptamer-based bioanalytical methods / Sara Tombelli, Maria Minunni, and Marco Mascini -- Surface imprinting: integration of recognition and transduction / Yanxiu Zhou, Bin Yu, and Kalle Levon -- Phage as biospecific probes / Valery A. Petrenko and Jennifer R. Brigati -- Upconverting phosphors for detection and identification using antibodies / David E. Cooper ... [et al.] -- Mathematical aspects of immunoassays / James F. Brady -- Immunochemical techniques in biological monitoring / Raymond E. Biagini, Cynthia A. F. Strile, and John E. Snawder -- Target and non-targeted approaches for detecting genetically modified organisms / Farid E. Ahmed -- Bioanalytical diagnostic test for measuring prions / Loredana Ingrosso, Maurizio Pocchiari, and Franco Cardone -- Environmental applications of immunoaffinity chromatography / Annette Moser, Mary Anne Nelson, and David S. Hage -- Sol-gel immunoassays and immunoaffinity chromatography / Miriam Altstein and Alisa Bronshtein -- Electrochemical immunoassays and immunosensors / Niina J. Ronkainen-Matsuno, H. Brian Halsall, and William R. Heineman -- Biosensors for environmental monitoring and homeland security / Kanchan A. Joshi, Wilfred Chen, and Ashok Mulchandani -- Bioarrays: current applications and concerns for developing, selecting and using array technology / Joany Jackman -- Microelectrode protein microarrays / Kilian Dill ... [et al.] -- Bioconjugated quantum dots for sensitive and multiplexed immunoassays / Xiaohu Gao ... [et al.] -- Nanotechnology and the future of bioanalytical methods / Lon Porter.
- Immunoassay handbook : theory and applications of ligand binding, ELISA, and related techniques. 4th ed.2013 ScienceDirectedited by David Wild ; associate editors, Rhys John [and others].How to use this book / David Wild -- Immunoassay for beginners / David Wild -- Immunoassay performance measures / Chris Davies -- Principles of competitive and immunometric assays (including ELISA) / Chris Davies -- Non-competitive immunoassays for small molecules : the anti-complex and selective antibody systems / Colin H. Self ... [et al.] -- Homogeneous immunoassays / Edwin F. Ullman -- Lateral flow immunoassay systems : evolution from the current state of the art to the next generation of highly sensitive, quantitative rapid assays / Brendan O'Farrell -- Ambient analyte assay / Roger Ekins -- Free analyte immunoassay / Nic D. Christofides -- Qualitative immunoassay : features and design / Jianwen He, Simon Parker -- Detection of antibodies relevant to infectious disease / Steven Binder, Jennifer A. Isler -- Microsphere-based multiplex immunoassays : development and applications using Luminex® Xmap® technology / Sherry A. Dunbar, Michaela R. Hoffmeyer -- Lab-on-a-chip, micro- and nanoscale immunoassay systems, and microarrays / Simon Rattle ... [et al.] -- Immunological biosensors / Jason Reed, James K. Gimzewski -- Surface plasmon resonance in binding site, kinetic, and concentration analyses / Robert Karlsson -- Measurement of single protein molecules using digital ELISA / David M. Rissin, David H. Wilson, David C. Duffy -- Antibodies / Eryl Liddell -- Signal generation and detection system (excluding homogeneous assays) / Ian Weeks, Larry J. Kricka, David Wild -- Separation systems / David Wild, Wlad Kusnezow -- Conjugation methods / Alastair H. Dent -- Standardization and calibration / David Wild, Chris Sheehan -- Calibration curve fitting / John Dunn, David Wild -- The foundations of immunochemistry / Robert F. Ritchie -- Immunohistochemistry and immunocytochemistry / Simon Renshaw -- Practical guide to ELISA development / Jianwen He -- Method evaluation : a practical guide / Chris Sheehan, Jianwen He, Mari Smith -- Interferences in immunoassay / Jason Y. Park, Larry J. Kricka -- Immunoassay development in the in vitro diagnostic industry / Doug Brandt, Steve Figard -- Sample collection, including participant preparation and sample handling / Colin Wilde ... [et al.] -- Quality assurance / Catharine M. Sturgeon -- Point-of-care testing / James H. Nichols -- Choosing an automated immunoassay system / Lori J. Sokoll -- Immunoassay troubleshooting guide / David Wild, Jianwen He -- Introduction to immunoassay product technology in clinical diagnostic testing / David Wild, Chris Sheehan, Steve Binder -- Market trends / David Huckle -- Lateral flow and consumer diagnostics / Sarah Tiplady -- Consumer diagnostics : Clearblue pregnancy and fertility testing / Sarah Tiplady -- The Triage® system / Thomas I. Koshy, Kenneth F. Buechler -- Stratus® CS Acute Care[TM] STAT fluorometric analyzer / Amy Sarli, W.N. McLellan -- IMX® / Kent Ford -- AXSYM® / Theresa Donahoe -- Abbott Architect® family of analyzers / Frank A. Quinn, David A. Armbruster -- Advia Centaur® XP / Jean Metzar -- Immulite® and Immulite 1000 / Arthur L. Babson -- VITROS® ECiQ Immunodiagnostic System, VITROS® 3600 Immunodiagnostic System, and VITROS® 5600 Integrated System / John W. Backus, David Wild -- VITROS® Immuno-Rate and Microtip[TM] assays / John W. Backus, Susan J. Danielson, David A. Hilborn -- Access 2 / Katherine M. Leith -- DXI 600 and DXI 800 / Katherine M. Leith -- Elecsys® immunoassay systems / Mary Beth Myers -- PRISM[TM] / Dinesh Shah, Jim Stewart -- Phadia Laboratory Systems / Angela Gore, Gareth Evans, Mats Rilvën -- Immunoassay applications in veterinary diagnostics / Thomas P. O'Connor, Jr. ... [et al.] -- Ligand binding assays in drug development / Jeffrey M. Sailstad ... [et al.] -- Clinical concepts / Chris Davies -- Thyroid / Rhys John ... [et al.] -- The adrenal cortex / Les Perry, Sami Medbak -- Bone and calcium metabolism / William D. Fraser, Kay W. Colston, John C. Stevenson -- Infertility / Michael J. Wheeler -- In vitro fertilization and embryo transfer (IVF-ET) / Richard Fleming, Sherry Faye -- Hirsutism and virilization in the female / Michael J. Wheeler -- Pregnancy / Kevin Spencer, Tim Chard -- Growth and growth hormone deficiency / Gill Rumsby ... [et al.] -- Diabetes mellitus / Penny Clark, Tim McDonald -- Hematology / Katy Evans ... [et al.] -- Cardiac markers / Deborah French, Alan H.B. Wu -- Cancer markers / Hoon H. Sunwoo, Mavanur R. Suresh -- Allergy / Marcos Alcocer, Lars Yman -- Autoimmune disease / David F. Keren -- Gastrointestinal tract / Arne Reseth ... [et al.] -- Hepatitis / Ravi Kaul -- HIV-1 and HIV-2 : causative agents of AIDS / Catherine A. Brennan, Sushil G. Devare -- Viral diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Bacterial diseases / Carey-Ann D. Burnham, Christopher Doern, Steven R. Binder -- Parasites and fungi / STeven R. Binder, Patrice D. Sarfati -- Therapeutic drug monitoring (TDM) / Philip A. Routledge, Alun D. Hutchings -- Drugs of abuse / Alun D. Hutchings, Brian Widdop.
- 2006 SpringerE. Vivier and M. Colonna (eds.).
- Immunobiology of proteins and peptides : [proceedings of the First International Symposium on Immunobiology of Proteins and Peptides, held in Minneapolis, Minnesota, September 25-28, 1977]1978-edited by M.Z. Atassi and A.B. Stavitsky.
- 2010 SpringerRichard W. Burry.
- 2015 Springer Protocolsedited by Adalberto Merighi and Laura Lossi, Department of Veterinary Sciences, University of Torino, Grugliasco, Torino, Italy.Machine generated contents note: 1.The Evolution of Immunocytochemistry in the Dissection of Neural Complexity / Laura Lossi -- pt. I Immunocytochemistry in Non-Mammalian Brain -- 2.Immunofluorescence and Genetic Fluorescent Labeling Techniques in the Drosophila Nervous System / Christian Wegener -- 3.Immunohistochemical Analysis of Neuronal Networks in the Nervous System of Octopus vulgaris / Graziano Fiorito -- 4.Genetic Mosaic Labeling and Immunofluorescence Techniques in Zebrafish Brain / Yoshihiro Yoshihara -- pt. II Detection of Cell Proliferation and Neurogenesis -- 5.Immunocytochemical Phenotype of Differentiating Neurons / Antonio Carai -- 6.Immunocytochemical Identification of Mammalian Differentiating Neurons in the Process of Adult Neurogenesis in the Hippocampal Dentate Gyrus / Oliver von Bohlen und Halbach -- 7.Identification of Proliferating and Migrating Cells by BrdU and Other Thymidine Analogs: Benefits and Limitations / Pasko Rakic --
- 2012 Springer Protocolsedited by Frank T. Christiansen, Brian D. Tait.Major histocompatibility complex : a paradigm for studies of the human genome / Richard J.N. Allcock -- HLA typing by SSO and SSP methods / Heather Dunckley -- Methods for diagnostic HLA typing in disease association and drug hypersensitivity / Michael D. Varney [and others] -- HLA typing using bead-based methods / Daniel Trajanoski and Samantha J. Fidler -- HLA Typing by Direct DNA Sequencing / Linda K. Smith -- Data analysis of HLA sequencing using assign-SBT v3.6+ from conexio / Carla Wirtz and David Sayer -- Simple methods for the detection of HLA-G variants in coding and non-coding regions / Holger Nuckel [and others] -- Molecular typing of HLA-E / Nina Lauterbach [and others] -- Molecular analysis of complement component C4 gene copy number / Alison S.L. Castley and O. Patricia Martinez -- Genotyping of single nucleotide polymorphisms by 5' nuclease allelic discrimination / Mari Malkki and Effie W. Petersdorf -- High resolution MICA genotyping by sequence-based typing (SBT) / Yizhou Zou and Peter Stastny -- Standard methods for the management of immunogenetic data / Pierre-Antoine Gourraud [and others] -- Analytical methods for immunogenetic population data / Steven J. Mack [and others] -- Analytical methods for disease association studies with immunogenetic data / Jill A. Hollenbach [and others] -- Impact of HLA matching and HLA antibodies in organ transplantation : a collaborative transplant study view / Caner Susal and Gerhard Opelz -- Screening for antibodies against MICA by luminex flow cytometry / Yizhou Zou and Peter Stastny -- HLA antibody detection and characterization by solid phase immunoassays : methods and pitfalls / Andrea A. Zachary [and others] -- Detection and characterisation of alloreactive T cells / Mandvi Bharadwaj, Nicole A. Mifsud, and James McCluskey -- Detection of allo-HLA cross-reactivity by virus-specific memory T-cell clones using single HLA-transfected K562 cells / Lloyd J. D'Orsogna [and others] -- Separation and cryopreservation of lymphocytes from spleen and lymph node / Gabriella Tassone and Samantha J. Fidler -- Crossmatching by Complement-Dependent Lymphocytotoxicity / Samantha J. Fidler -- Lymphocyte crossmatch by flow cytometry for Kidney Transplantation / Jonathan Downing -- Overview of the killer cell immunoglobulin-like receptor system / Raja Rajalingam -- KIR typing by non-sequencing methods : polymerase-chain reaction with sequence-specific primers / David Ordonez [and others] -- Killer cell immunoglobulin-like receptors (KIR) typing by DNA sequencing / Lihua Hou [and others] -- Overview of methods required to evaluate donor NK cell alloreactivity for haploidentical haemopoietic stem cell transplantation / Andrea Velardi -- Detection of NK cell alloreactivity by flow cytometric CD107a assay / Dianne De Santis [and others] -- Clinical production and therapeutic applications of alloreactive natural killer cells / David H. McKenna [and others] -- Minor histocompatibility antigen typing by DNA sequencing for clinical practice in hematopoietic stem-cell transplantation / Eric Spierings and Els Goulmy -- Donor registries and search strategies / Carolyn K. Hurley, Machteld Oudshoorn, and Michelle Setterholm -- Cytokine gene polymorphisms : methods of detection and biological significance / Gurvinder Kaur and Narinder Mehra -- IMGT® tools for the nucleotide analysis of immunoglobulin (IG) and T cell receptor (TR) V-(D)-J repertoires, polymorphisms, and IG mutations : IMGT/V-QUEST and IMGT/HighV-QUEST for NGS / Eltaf Alamyar -- IMGT/DomainGapAlign : the IMGT® tool for the analysis of IG, TR, MH, IgSF, and MhSF domain amino acid polymorphism / Francois Ehrenmann and Marie-Paule Lefranc -- Human Gm, Km, and Am allotypes and their molecular characterization : a remarkable demonstration of polymorphism / Marie-Paule Lefranc and Gerard Lefranc.
- 2006 SpringerJorge Oksenberg, David Brassat [editors].HLA and autoimmunity : structural basis of immune recognition / Kai W. Wucherpfennig -- Genomic variation and autoimmune disease / Silke Schmidt and Lisa F. Barcellos -- Endocrine diseases : type I diabetes mellitus / Regine Bergholdt, Michael F. McDermott, and Flemming Pociot -- Endocrine diseases : Graves' and Hashimoto's diseases / Yoshiyuki Ban and Yaron Tomer -- Central and peripheral nervous system diseases / Dorothée Chabas, Isabelle Cournu-Rebeix, and Bertrand Fontaine -- Immunogenetics of rheumatoid arthritis, systemic sclerosis, and systemic lupus erythematosus / Allison Porter and J. Lee Nelson -- Gastroenterologic and hepatic diseases / Marcela K. Tello-Ruiz, Emily C. Walsh, and John D. Rioux -- Inflammatory myopathies : dermatomyositis, polymyositis, and inclusion body myositis / Renato Mantegazza and Pia Bernasconi -- Hematologic diseases : autoimmune hemolytic anemia and immune thrombocytopenic purpura / Mattias Olsson ... [et al.] -- Genetics of autoimmune myocarditis / Mehmet L. Guler, Davinna Ligons, and Noel R. Rose.
- 2008 Springer[edited by] Marco van de Weert, Eva Horn Møller.
- 2008 Springeredited by Christian Schönbach, Shoba Ranganathan, and Vladimir Brusic.IMGT-ONTOLOGY, IMGT databases, tools, and web resources for immunoinformatics / Marie-Paule Lefranc -- IMGT standardization for molecular characterization of the T cell receptor/peptide/MHC complexes / Quentin Kaas ... [et al.] -- Structural immunoinformatics / Choba Ranganathan, Joo Chuan Tong, and Tin Wee Tan -- In silico QSAR-based predictions of class I and class II MHC epitopes / Channa K. Hattotuwagama ... [et al.] -- Allergen bioinformatics / Bernett T.K. Lee and Vladimir Brusic -- Immunoinformatics applied to modifying and improving biological therapeutics / Anne S. De Groot ... [et al.] -- Plasticity of dentritic cell transcriptional responses to antigen: functional states of dendritic cells / Paul Kellam and Antonia Kwan -- Understanding the immune system sytem by computer-aided modeling / Massimo Bernaschi and Filippo Castiglione -- Simulation of HIV-1 molecular evolution in response to chemokine coreceptors and antibodies / Jack da Silva -- MUTANT MOUSE: bona fide biosimulator for the functional annotation of gene and genome networks / Yoichi Gondo.
- 2007 Springer Protocolsedited by Darren R. Flower.
- 2014 Springer Protocolsedited by Rajat K. De, Namrata Tomar.Part I: Immunoinformatics: transition from basic biology to informatics -- 1. A brief outline of the immune system / Namrata Tomar and Rajat K. De -- 2. Crosstalk between the metabolic and immune systems / Namrata Tomar and Rajat K. De -- 3. Immunoinformatics: a brief review / Namrata Tomar and Rajat K. De -- Part II: Databases -- 4. Immunoinformatics of the V, C and G domains: IMGT® definitive system for IG, TR and IgSF, MH and MhSF / Marie-Paule Lefranc -- 5. IMGT/HLA and the immuno polymorphism database / James Robinson, Jason A. Halliwell, and Steven G.E. Marsh -- 6. Databases for T-cell epitopes / Chun-Wei Tung -- 7. Databases for B-cell epitopes / Juan Liu and Wen Zhang -- 8. Antigen-Antibody Interaction Database (AgAbDb): a compendium of antigen-antibody interactions / Urmila Kulkarni-Kale, Snehal Raskar-Renuse, Girija Natekar-Kalantre, and Smita A. Saxena -- 9. Allergen databases / Gaurab Sircar, Debasree Sarkar, Swati Gupta Bhattacharya, and Sudipto Saha -- Part III: Tools for prediction -- 10. Prediction of conformational B-cell epitopes / Wen Zhang, Yanqing Niu, Yi Xiong, and Meng Ke -- 11. Computational prediction of B cell epitopes from antigen sequences / Jianzhao Gao and Lukasz Kurgan -- 12. Machine learning based methods for prediction of linear B-cell epitopes / Hsin-Wei Wang and Tun-Wen Pai -- 13. Mimotope-based prediction of B-cell epitopes / Jian Huang, Bifung He, and Peng Zhou -- 14. Hybrid methods for B-cell epitope prediction: approaches to the development and utilization of computational tools for practical applications / Salvador Eugenio C. Caoili -- 15. Building classifier ensembles for B-cell epitope prediction / Yasser El-Manzalawy and Vasant Honavar -- 16. Multiplex peptide-based B-cell epitope mapping / Sanne M.M. Hensen, Merel Derksen, and Ger J.M. Pruijn -- 17. Classification of Human Leukocyte Antigen (HLA) supertypes / Mingjun Wang and Mogens H. Claesson -- 18. Customized predictions of peptide-MHC binding and T-cell epitopes using EPIMHC / Magdalena Molero-Abraham, Esther M. Lafuente, and Pedro Reche -- 19. T-cell epitope prediction methods: an overview / Dattatraya V. Desai and Urmila Kulkarni-Kale -- 20. Computational antigenic epitope prediction by calculating electrostatic desolvation penalties of protein surfaces / Sebastien Fiorucci and Martin Zacharias -- 21. In silico prediction of allergenic proteins / Gaurab Sircar, Bodhisattwa Saha, Swati Gupta Bhattacharya, and Sudipto Saha -- 22. Prediction of virulence factors using bioinformatics approaches / Rupanjali Chaudhuri and Srinivasan Ramachandran -- Part IV: Systems biology approaches in immunoinformatics -- 23. A systems biology approach to study systemic inflammation / Bor-Sen Chen and Chia-Chou Wu -- 24. Procedures for mucosal immunization and analyses of cellular immune response to candidate HIV vaccines in murine and nonhuman primate models / Shailbala Singh, Pramod Nehete, Patrick Hanley, Bharti Nehete, Guojun Yang, Hong He, Scott M. Anthony, Kimberly Schluns, and K. Jagannadha Sastry -- 25. Immunoinformatics and systems biology in personalized medicine / Guillermo Lopez-Campos, Jesús F. Bermejo-Martin, Raquel Almansa, and Fernando Martin-Sanchez -- Part V: Applications of immunoinformatics -- 26. The role of small RNAs in vaccination / Ajeet Chaudhary and Sunil Kumar Mukherjee -- 27. Structure-based clustering of Major Histocompatibility Complex (MHC) proteins for broad-based T-cell vaccine design / Joo Chuan Tong, Tin Wee Tan, and Shoba Ranganathan -- 28. Immunoinformatics, molecular modeling, and cancer vaccines / Seema Mishra and Subrata Sinha -- 29. Investigating host pathogen behavior and their interaction using genome-scale metabolic network models / Priyanka P. Sadhukhan and Anu Raghunathan -- 30. Mathematical models of HIV replication and pathogenesis / Dominik Wodarz.
- 2011 SpringerFrancesco M. Marincola, Ena Wang, editors.pt. 1. Preamble -- pt. 2. The immune biology of rejection : basic principles -- pt. 3. Circulating patterns associated with chronic and acute immune pathology -- pt. 4. Tissue-specific patterns associated with chronic inflammatory processes -- pt. 5. Signatures associated with acute rejection.
- 2010 SpringerTakashi Saito, Facundo D. Batista, editors.Insights into function of the immunological synapse from studies with supported planar bilayers / M.L. Dustin -- Immunological synapses within context: patterns of cell-cell communication and their application in T-T interactions / J. Doh and M.F. Krummel -- Molecular and cellular dynamics at the early stages of antigen encounter: the B-cell immunological synapse / Y.R. Carrasco -- Inhibitory and regulatory immune synapses / P. Eissmann and D.M. Davis -- The immunological synapse, TCR microclusters, and T cell activation / T. Yokosuka and T. Saito -- Signaling amplification at the immunological synapse / A. Viola, R.L. Contento and B. Molon -- Multiple microclusters: diverse compartments within the immune synapse / S.C. Bunnell -- A conformation-induced oligomerization model for B cell receptor microclustering and signaling / P. Tolar and S.K. Pierce -- Co-receptors and recognition of self at the immunological synapse / N.R. Gascoigne ... [et al.] -- Vesicle traffic to the immunological synapse: a multifunctional process targeted by lymphotropic viruses / A. Alcover and M.I. Thoulouze -- Plasticity of immunological synapses / S. Valitutti and L. Dupre -- APC, T cells, and the immune synapse / P. Reichardt, B. Dornbach and M. Gunzer.Also available: Print – yyyy
- 2007 Springer Protocolsedited by Paul J. Fairchild.
- 2005 SpringerJ. Langhorne (ed.).The dissection of CD8 T cells during liver-stage infection / U. Krzych and R.J. Schwenk -- Early interactions between blood-stage Plasmodium parasites and the immune system / B.C. Urban, R. Ing, and M.M. Stevenson -- Longevity of the immune response and memory to blood-stage malaria infection / A.H. Achtman ... [et al.] -- Experimental models of cerebral malaria / C. Engwerda ... [et al.] -- Glycosylphosphatidylinositols in malaria pathogenesis and immunity : potential for therapeutic inhibition and vaccination / C.S. Boutlis ... [et al.] -- The immunology and pathogenesis of malaria during pregnancy / J.G. Beeson and P.E. Duffy.
- 2015 SpringerNorbert Müller, Aye-Mu Myint, Markus J. Schwarz, editors.Psychiatric disorders are one of the most dramatic burdens for humankind. The role of immune dysfunction in the pathophysiology of these disorders has emerged during the last years, because there has been tremendous progress in psychoneuroimmunological research. Many results are presented here by pioneers in the field. The book addresses various effects of the immune system on the pathophysiology and course of psychiatric disorders and highlights the possible future impact on treatment decisions of various psychiatric disorders, including schizophrenia and depression. The contributions cover the role of in utero immune challenges on the development of schizophrenia, the role of infections, and autoimmune diseases and mild immune activation in the development of depression and schizophrenia, the influence of immune responses in other disorders such as Tourette's, Alzheimer's, and OCD, the connections between mental and physical pain as well as between anti-inflammatory and antipsychotic drugs.
- 2009Mary Louise Turgeon.
- 2017 ClinicalKeyMatthew Helbert.1. Introduction to the immune system -- 2. Basic concepts and components of the immune system -- 3. Introduction to the antigen recognition -- 4. Antigens and antibody structure -- 5. Antibody-antigen interaction -- 6. Antibody diversity -- 7. The T-cell receptor -- 8. Major histocompatibility complex -- 9. Review of antigen recognition -- 10. Antigen processing and presentation -- 11. Lymphocyte activation -- 12. Hematopoiesis -- 13. Organs and tissues of the immune system -- 14. B-cell development -- 15. T-cell development -- 16. T-cell interactions and T=cell help -- 17. Immunologic memory and homeostasis -- 18. Regulation of the immune system -- 19. Brief review of immune physiology -- 20. Constitutive defense including complement -- 21. Phagocytes -- 22. Killing in the immune system -- 23. Inflammation -- 24. Cytokines in the immune system -- 25. Infections and vaccines -- 26. Hypersensitivity reactions -- 27. Immediate hypersensitivity (Type I): allergy -- 28. How autoimmune disease develops -- 29. Antibody-mediated hypersensitivity (Type II) -- 30. Immune complex disease (Type III hypersensitivity ) -- 31. Delayed hypersensitivity (Type IV) and review of hypersensitivity reactions -- 32. Primary immunodeficiency -- 33. Primary immunodeficiency -- 33. Secondary immunodeficiency -- 34. Transplantation -- 35. Tumor immunology -- 36. Biopharmaceuticals.
- 2012 ScienceDirectDennis K. Flaherty.With a new pharmacy-specific approach to immunology, Immunology for Pharmacy prepares pharmacists for practice by providing a complete understanding of the basis of immunology and the consequences of either suppressing or enhancing immune function. It covers key subjects such as prophylaxis and vaccination, antibodies as therapeutic and diagnostic agents, biological modifiers, and the rationale for use and mechanisms of therapeutic agents. Written by experienced author and educator Dennis Flaherty, this book presents topics with a logical, step-by-step approach, explaining concepts and their practical application. A companion Evolve website reinforces your understanding with flashcards and animations. Pharmacy-specific coverage narrows the broad field of immunology to those areas most pertinent and clinically relevant to pharmacy students. 165 full-color illustrations help to illuminate difficult concepts. Factors That Influence the Immune Response chapter covers biological agents including bacteria, viruses, and fungi, and their related toxins and how they relate to the immune system. Three chapters on vaccinations prepare you for this important part of the pharmacist's role by discussing cancer treatment with whole tumor vaccines, cell vaccines, and viral vector vaccines, describing other vaccines such as recombinant vaccines and plant vaccines, and examining how diseases such as diphtheria, whooping cough, and tetanus respond to vaccinations. A summary of drugs used in treating each condition helps you understand typical treatments and their immunological mechanisms, so you can choose proper treatments. Integrated information makes it easier to understand how various parts of the immune system work together, leading to a better understanding of immunology as a whole. A unique focus on practical application and critical thinking shows the interrelationship of concepts and makes it easier to apply theory to practice. Information on AIDS covers the identification and treatment of both strains of HIV as well as AIDS, preparing you for diseases you will see in practice. Unique student-friendly features simplify your study with learning objectives and key terms at the beginning of each chapter, bulleted summaries and self-assessment questions at the end of each chapter, and a glossary at the back of the book. Over 60 tables summarize and provide quick reference to important material. A companion Evolve website includes animations and pharmacy terminology flashcards.
- 2014 SpringerAhmad Massoud, Nima Rezaei, editors.An Introduction on the old age and aging of the immune system -- The immune system, a marker and modulator of the rate of aging -- Age-associated alterations of pleiotropic stem cell and the therapeutic implication of stem cell therapy in aging -- A role for epigenetic modulation of the innate immune response during aging -- Basophil, eosinophil and neutrophil functions in the elderly -- Dendritic cells and dysregulated immunity in the elderly -- Natural killer cell immunosenescence and cancer in the elderly -- Pattern recognition receptors and aging -- Impact of ageing on T cell repertoire and immunity -- T cell mediated immunity in the immunosenescence process -- Biological and phenotypic alterations of T cells in aging -- T cells seen from the metabolic and aging perspective -- Age-related alterations in regulatory T cells -- Effects of aging on B cells -- The role of MicroRNAs in immunosenescence process -- Immunogenetics of Aging -- Aging immunity and infection -- Influenza infection in the elderly -- Optimising response to vaccination in the elderly -- Nutrition, immunity and aging -- Diet and immunosenescence -- Dietary Intake and impact of zinc supplementation on the immune functions in elderly: nutrigenomic approach -- Physiological and pathological role of reactive oxygen species in the immune cells -- Oxidative stress in aging -- Skin aging and the immune system -- Aging immunity and the impact of physical exercise.
- 2007 Springeredited by Gordon D. Brown and Mihai G. Netea.
- 2005 Kargervolume editor, Udo R. Markert.
- 2010 ScienceDirectedited by Dieter Kabelitz and Stefan H.E. Kaufmann.1. The Immune Response to Infectious Agents / Stefan H.E. Kaufmann, Dieter Kabelitz -- 2. Immunomagnetic Isolation of Subcellular Compartments / Vladimir Tchikov, Jürgen Fritsch, Dieter Kabelitz, Stefan Schütze -- 3. Use of Bioinformatics to Predict MHC Ligands and T-Cell Epitopes: Application to Epitope-Driven Vaccine Design / Anne S. De Groot, Tobias Cohen, Matthew Ardito, Lenny Moise, Bill Martin, Jay A. Berzofsky -- 4. Genetics of Susceptibility and Resistance to Infection / Aurelie Cobat, Marianna Orlova, Alexandre Alcaїs, Erwin Schurr -- 5. Proteomic Approaches to Study Immunity in Infection / Gustavo A.de Souza, Harald G. Wiker -- 6. Isolation and Characterization of Human Epithelial Antimicrobial Peptides and Proteins / Jens.-M. Schröder -- 7. Visualization and Functional Evaluation of Phagocyte Extracellular Traps / Maren von Köckritz-Blickwede, Ohn Chow, Mariam Ghochani, Victor Nizet -- 8. Killer Cell Assays / Patricia Graef, Veit R. Buchholz, Dirk H. Busch -- 9. Analysis of Intestinal T Cell Populations and Cytokine Productions / Jun Kunisawa, Hiroshi Kiyono -- 10. Isolation and Measuring the Function of Professional Phagocytes: Murine Macrophages / Leanne Peiser, Subhankar Mukhopadhyay, Richard Haworth, Siamon Gordon -- 11. Measuring Immune Responses In Vivo / Stefan Ehlers, Norbert Reiling, Christoph Hölscher, Sahar Aly -- 12. Murine and Guinea Pig Models of Tuberculosis / Diane J. Ordway, lan M. Orme -- 13. The Leishmaniasis Model / Pascale Kropf, Ulrich D. Kadolsky, Matthew Rogers, Thomas E. Cloke, Ingrid Müller -- 14. Animal Models of Mucosal Candida Infections / Flavia De Bernardis, Silvia Arancia, Silvia Sandini -- 15. Mucosal Immunity and Inflammation / Ulrich Steinhoff, Alexander Visekruna -- 16. CD8 T-Cell Immunotherapy of Cytomegalovirus Disease in the Murine Model / Niels A.W. Lemmermann, Jürgen Podlech, Christof K. Seckert, Kai A. Kropp, Natascha K.A. Grzimek, Matthias J. Reddehase, Rafaela Holtappels -- 17. Measuring Immune Responses In Situ: Immunofluorescent and Immunoenzymatic Techniques / Antje Müller, Torsten Goldmann, Ulrike Seitzer -- 18. Measuring Human Cytokine Responses / Hans Yssel, John Wijdenes, René de Waal Malefyt, Jean-François Mathieu, Jérôme Pène -- 19. Human Dendritic Cell Subsets / Hideki Ueno, Eynav Klechevsky, A. Karolina Palucka, Jacques Banchereau.
- 2005 Kargervolume editor: Udo R. Markert.
- 2006 Springer[edited by] Gil Mor.Evolution of the mammalian reproductive tract and placentation / Susan Richman and Frederick Naftolin -- Toll-like receptors and pregnancy / Vikki M. Abrahams and Gil Mor -- IL-10 and pregnancy / Shaun P. Murphy and Surendra Sharma -- Th1/Th2 balance of the implantation site in humans / Shigeru Saito, Satomi Miyazaki, and Yasushi Sasaki -- The regulation of human trophoblast apoptosis and survival during pregnancy / Shawn L. Straszewski-Chavez and Gil Mor -- Macrophages and pregnancy / Gil Mor, Roberto Romero, and Vikki M. Abrahams -- Potential role of glucocorticoids in the pathophysiology of intrauterine growth restriction (IUGR) / Seth Guller, Yuehong Ma, and Men-Jean Lee -- NK cells and pregnancy / Mikael Eriksson, Satarupa Basu, and Charles L. Sentman -- The role of corticotropin-releasing hormone (CRH) on implantation and immunotolerance of the fetus / Sophia N. Kalantaridou ... [et al.] -- Indoleamine 2,3 dioxygenase-dependent T cell suppression and pregnancy / Babak Baban, Phillip R. Chandler, and Andrew L. Mellor -- Leukemia inhibitory factor in reproduction / Levent M. Senturk and Aydin Arici -- Characterization of human dendritic cells at the materno-fetal interface / Ulrike Kämmerer ... [et al.] -- MHC molecules of the preimplantation embryo and trophoblast / Martina Comiskey, Carol M. Warner, and Danny J. Schust -- Actions of seminal plasma cytokines in priming female reproductive tract receptivity for embryo implantation / Sarah A. Robertson ... [et al.] -- B7 family molecules in the placenta / Margaret G. Petroff -- The role of regulatory T cells in materno-fetal tolerance / Varuna R. Aluvihare and Alexander G. Betz -- The eutherian fetoembryonic defense system hypothesis: an update / Gary F. Clark ... [et al.] -- The nature and role of the decidual T cells / Lucia Mincheva-Nilsson and Vladimir Baranov -- Trophoblast cells as immune regulators / Gil Mor and Vikki M. Abrahams -- Inherited thrombophilias and early pregnancy loss / Jens Langhoff-Roos ... [et al.] -- Bi-directional cell trafficking during pregnancy: long-term consequences for human health / Kristina M. Adams and J. Lee Nelson -- Term and preterm parturition / Roberto Romero ... [et al.] -- Interleukin-1 and implantation / Jan-S. Krüssel ... [et al.] -- Immunology and pregnancy losses: HLA, autoantibodies and cellular immunity / Joanne Kwak-Kim, Joon Woo Kim, and Alice Gilman-Sachs.
- Adenosine receptors : therapeutic aspects for inflammatory and immune diseases — Developmental biology of peripheral lymphoid organs (158)
- Developments in hematology and immunology — Immunology of pregnancy (158)
- Immunology of the female genital tract — Neuroinflammation-- new insights into beneficial and detrimental functions (158)
- Neuroinflammation and CNS disorders — Wiley-Blackwell handbook of psychoneuroimmunology (156)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
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