Books by Subject
- Adenosine receptors : therapeutic aspects for inflammatory and immune diseases — Developments in T cell based cancer immunotherapies (162)
- Diagnostic imaging of infections and inflammatory diseases : a multidisciplinary approach — Immunology of pregnancy (162)
- Immunology of the female genital tract — Neuroinflammation and CNS disorders (162)
- Neutrophil methods and protocols. Second edition. [2nd ed.] — Wiley-Blackwell handbook of psychoneuroimmunology (159)
Allergy and Immunology
- 2007 CRCnetBASEedited by György Haskó, Bruce N. Cronstein, Csaba Szabó.
- 2007 Springeredited by Giamila Fantuzzi, Theodore Mazzone ; foreword by Andrew P. Goldberg and Susan K. Fried.The adipose organ / Saverio Cinti -- Metabolism of white adipose tissue / Michel Beylot -- Leptin / Malaka B. Jackson and Rexford S. Ahima -- Adiponectin / Aimin Xu, Yu Wang, and Karen S.L. Lam -- Vasoactive factors and inflammatory mediators produced in adipose tissue / Gema Frohbeck -- Regulation of the immune response by leptin / Victor Sanchez-Margalet ... [et al.] -- Leptin in autoimmune disease / Giuseppe Matarese -- Leptin and gastrointestinal inflammation / Arvind Batra and Britta Siegmund -- Adiponectin and inflammation / Yuji Matsuzawa -- Macrophages, adipocytes, and obesity / Anthony W. Ferrante, Jr. -- Interactions of adipose and lymphoid tissues / Caroline M. Pond -- Adipose tissue and mast cells: adipokines as Yin-Yang modulators of inflammation / George N. Chaldakov ... [et al.] -- Bone marrow adipose tissue / Patrick Laharrague and Louis Castella -- Environmental aspects of obesity / Lisa Diewald, Myles S. Faith, and Meredith S. Dolan -- The genetics of obesity: five fundamental problems with the famine hypothesis / John R. Speakman -- Developmental perspectives on the origins of obesity / Cristopher W. Kuzawa, Peter D. Gluckman, and Mark A. Hanson -- The epidemiology of obesity / Carol A. Braunschweig -- Inherited and acquired lipodystrophies: disorders of adipose tissue, development, differentiation, and death / Vinaja Simha and Anil Agarwal -- Mechanisms of cachexia / Robert H. Mak and Wai W. Cheung -- Adipose tissue and insulin resistance / Stephen E. Borst -- Adipokines in non-alcoholic fatty liver disease / Ancha Baranova and Zobair M. Younossi -- Adiposity and cancer / Eugenia E. Calle -- Obesity and cardiovascular disease / Alison M. Morris, Paul Poirier, and Robert H. Eckel -- Obesity and asthma / Elisabeth Luder -- Adiposity and kidney disease / Srinivasan Beddhu and Bonnie Ching-Ha Kwan -- Obesity and joint disease / Andrew J. Teichtahl, Anita E. Wluka, and Flavia M. Cicuttini -- Effect of weight loss on disease / Sergio Jose Bardaro, Dennis Hong, and Lee Swanstrom.
- 2014 Future Mededitor, Denise Anne Moneret-Vautrin.Advances in anaphylaxis management / Denise Anne Moneret-Vautrin -- Anaphylaxis : classification and clinical symptoms / Johannes Ring, Jarmila Liptak & Knut Brockow -- Pathophysiology : IgE-mediated and non-IgE-mediated anaphylaxis / Denise Anne Moneret-Vautrin -- Risk factors for fatal anaphylaxis / Richard Pumphrey & Gunter Sturm -- Etiologies of anaphylaxis / Margitta Worm -- Biomarkers for the evaluation of severity of anaphylaxis / Julia Upton & Peter Vadas -- Role of specific IgE testing in allergy diagnosis / Sandrine Jacquenet, Denise-Anne Moneret-Vautrin & Bernard E. Bihain -- Treatment algorithm for anaphylaxis and prognosis / Ben Gibbison & Jasmeet Soar -- Food anaphylaxis prevention / Martine Morisset -- Hymenoptera anaphylaxis : indications and results of immunotherapy / Ulrich R. Müller & Arthur Helbling -- Index.
- 2013 SpringerEric O. Freed, editor.Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.
- 2014 SpringerJoseph D. Rosenblatt, Eckhard R. Podack, Glen N. Barber, Augusto Ochoa, editorsRecent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
- 2012 Kargervolume editor, Lars E. French."The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1 to 5 percent for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists." -- publisher's site.
- 2015 SpringerAlessandro Plebani, Vassilios Lougaris, editors.This book provides an updated overview of agammaglobulinemia, a rare form of primary immunodeficiency which is considered the prototype of the congenital humoral defects, and which is characterized by the absence of peripheral B cells and very low serum immunoglobulin levels. The book opens by discussing the highly orchestrated early B cell development in the bone marrow and the genes involved based on both human and animal models. The pathogenesis and clinical presentation of X-linked agammaglobulinemia, caused by mutations in the BTK (Bruton's tyrosine kinase) gene, are then presented in detail, followed by descriptions of the clinical manifestations and molecular basis of the less frequent autosomal recessive and autosomal dominant forms of agammaglobulinemia. Patients' management in terms of respiratory complications, gammaglobulin replacement therapy and the potential value of novel experimental therapeutic strategies are discussed. The book's closing chapters offer a comprehensive and updated description of mutations in the BTK gene, and the expression and function of BTK in cells other than B cells.
- 2015 Springeredited by Mieczyslaw Pokorski.Respiratory allergy is constantly encountered and is sharply on the rise, particularly in the two most vulnerable age-groups: young children and seniors. Allergy results in airway hyperactivity and increased airway resistance, with all inflammatory sequelae being ensued. The chapters show how respiratory allergy research is interconnected with other disciplines by discussing neurotransmitter, membrane receptor, and ionic channel mechanisms of allergy and by giving diagnostic and pharmacological cues on desensitization and therapy.Also available: Print – 2015
- 2007 Springeredited by Phil Lieberman and John A. Anderson.Allergic disease: pathophysiology and immunopathology -- Approach to the allergic patient -- Diagnostic tests in allergy -- Environmental allergens -- Anaphylaxis -- Insect sting allergy -- The child with asthma -- Asthma in adults: diagnosis and management -- Allergic rhinitis: diagnosis and treatment -- Sinusitis and otitis media -- Diagnosis and treatment of ocular allergy -- Urticaria and angioedema -- Atopic dermatitis -- Contact dermatitis and other contact reactions -- Food allergy and intolerance -- Allergic and allergic-like reactions to drugs and other therapeutic agents -- Antihistamines -- β-adrenergic agonists -- Theophylline -- Antileukotriene agents in the management of asthma -- Cromolyn and nedocromil: nonsteroidal anti-inflammatory therapy for asthma and other allergic diseases -- Anticholinergic agents in respiratory diseases -- Glucocorticoid therapy in asthma -- Anti-IgE therapy -- Environmental control of respiratory indoor allergens -- Allergen immunotherapy -- Controversies in allergy and allergy-like diseases -- The patient with 'too many infections'.
- 2016 SpringerMassoud Mahmoudi, editor.Chapter 1. Introduction to Immune System -- Chapter 2. The History and Physical Examination of the Allergic Patient -- Chapter 3. Prevalence of Allergic Diseases in Children, adults and Elderly -- Chapter 4. Allergic Diseases of the Eye -- Chapter 5. Prevalence of Pollens in the United States and Elsewhere -- Chapter 6. Allergic Rhinitis: Diagnosis and Treatment -- Chapter 7. The Effect of Rhinitis on Sleep, Quality of Life, Daytime Somnolence, and Fatigue -- Chapter 8. Sinusitis -- Chapter 9. Allergic Diseases of the Ear -- Chapter 10. Cough and Allergic Diseases -- Chapter 11. Urticaria and Angioedema -- Chapter 12. Atopic Dermatitis -- Chapter 13. Allergic Contact Dermatitis -- Chapter 14. Pediatric Asthma -- Chapter 15. Adult Asthma -- Chapter 16. Exercise-Induced Bronchoconstriction -- Chapter 17. Occupational Asthma -- Chapter 18. Asthma and Pregnancy -- Chapter 19. Asthma and Pseudo-asthma -- Chapter 20. Hypersensitivity Pneumonitis -- Chapter 21. All Allergic Bronchopulmonary Aspergillosis -- Chapter 22. Serum Sickness -- Chapter 23. Complement Systems and Allergy Diseases -- Chapter 24. Food Allergy -- Chapter 25. Insect Allergy -- Chapter 26. Latex Allergy -- Chapter 27. Drug Allergy -- Chapter 28. Smoke, Pollution, and Allergy -- Chapter 29. Sick Building Syndrome -- Chapter 30. Allergy in the Elderly -- Chapter 31. Diagnostic Testing in Allergic Diseases -- Chapter 32. Primary Immunodeficiencies -- Chapter 33. HIV Infection -- Chapter 34. Complementary and Alternative Medicine in treatment of Allergic and Asthmatic Disease -- Chapter 35. Nutrition, Diet and Allergic Diseases -- Chapter 36. Prevention and Control Measures in Management of Allergic Diseases -- Chapter 37. Antihistamines and Mast Cell Stabilizers -- Chapter 38. Bronchodilators -- Chapter 39. Glucocorticoids -- Chapter 40. Anti-Immunoglobulin E (IgE) Therapy -- Chapter 41. Allergy Immunotherapy -- Chapter 42. Anaphylaxis and Its Management. .
- 2006 Kargervolume editor, Reto Crameri.
- 2016 SpringerMieczyslaw Pokorski, editor.Chapter 1. Spirometry or Body Plethysmography for the Assessment of Bronchial Hyperresponsiveness, R. Merget, F. Nensa, E. Heinze, D. Taeger, T. Bruening -- Chapter 2. Clinical Effects, Exhaled Breath Condensate pH and Exhaled Nitric Oxide in Humans after Ethyl Acrylate Exposure, F. Hoffmeyer, J. B?nger, C. Mons?, H. Berresheim, B. Jettkant, A. Beine, T. Br?ning, K. Sucker -- Chapter 3. Effectiveness of PCR and Immunofluorescence Techniques for Detecting Human Cytomegalovirus in Blood and Bronchoalveolar Lavage Fluid, A. Ro?y, K. Duk, B. Szumna, P. Jagu?, D. Gawryluk, J. Chorostowska-Wynimko -- Chapter 4. The Role of Ion Channels to Regulate Airway Ciliary Beat Frequency During Allergic Inflammation, M. Joskova, M. Sutovska, P. Durdik, D. Koniar, L. Hargas, P. Banovcin, M. Hrianka, V. Khazaei, L. Pappova, S. Franova -- Chapter 5. Content of Asthmagen Natural Rubber Latex Allergens in Commercial Disposable Gloves, C. Bittner, M. Velasco Garrido, L.H. Krach, V. Harth -- Chapter 6. Thermal Sensitivity and Dimethyl Sulfoxide (DMSO), K. Takeda, M. Pokorski, Y. Okada -- Chapter 7. IgE Reactivity, Work Related Allergic Symptoms, Asthma Severity, and Quality of Life in Bakers with Occupational Asthma, C. Bittner, M. Velasco Garrido, V. Harth, A.M. Preisser -- Chapter 8. Effects of Selective Inhibition of PDE4 by YM976 on Airway Reactivity and Cough in Ovalbumin-Sensitized Guinea Pigs, J. Mokry, A. Fulmekova, I. Medvedova, M. Kertys, P. Mikolka, P. Kosutov?, D. Mokr? -- Chapter 9. Airway Defense Control Mediated via Voltage-Gated Sodium Channels, M. Kocmalova, M. Joskova, S. Franova, P. Banovcin, M. Sutovska -- Chapter 10 -- Virological Characteristics of the 2014/2015 Influenza Season Based on Molecular Analysis of Biological Material Derived from I-MOVE, E. Hallmann-Szeli?ska, K. Bednarska, M. Korczy?ska, I. Paradowska-Stankiewicz, L.B. Brydak.Also available: Print – 2016
- 2012 Kargervolume editor John Bienenstock.Relations between asthma and psychological distress: an old idea revisited -- Brain and asthma: what are the linkages? -- Stress-related programming of autonomic imbalance: role in allergy and asthma -- Role of parasympathetic nerves and muscarinic receptors in allergy and asthma -- Developmental programming of allergic diseases -- Mind-body interrelationship in DNA methylation -- Neurotrophins in chronic allergic airway inflammation and remodeling -- Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system -- Allergen-induced neuromodulation in the respiratory tract -- Role of microbiome in regulating the HPA axisd and its relevance to allergy -- Autonomic regulation of anti-inflammatory activities from salivary glands -- Mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses -- Neural and behavioral correlates of food allergy -- Neuroendocrine-immune connection regulates chronic inflammatory disease in allergy -- Itch and the brain.
- 2015 SpringerAilin Tao, Eyal Rax, editors.Allergic Disease Epidemiology -- The Pathogenesis of Allergy: A Brief Introduction -- Genetics and Epigenetic Regulation in Allergic Diseases -- Cross-Reactivity -- From Allergen Extracts to Allergen Genes and Allergen Molecules -- Allergen Gene Cloning -- High Throughput Screening of Allergy -- Surrogate Markers for Allergen-Specific Immunotherapy -- Immune Responses to Allergens in Atopic Disease: Considerations for Bioinformatics -- Antigenicity, Immunogenicity and Allergenicity -- Bioinformatic Classifiers for Allergen Sequence Discrimination -- Strategies for the Modification and Evaluation of Allergenicity -- Bioinformatics Methods to Predict Allergen Epitopes -- Allergen Database.
- v. 1-6, 2009-2010. Springerv. 2, 2009 Springerv. 3, 2009 Springerv. 4, 2009 Springerv. 5, 2010 Springerv. 6, 2010 SpringerRuby Pawankar, Stephen T. Holgate, Lanny J. Rosenwasser, editors.v. 1. Epigenetics, allergens and risk factors -- v. 2. Classification and pathomechanisms -- v. 3. Clinical manifestations -- v. 4. Diagnosis and health economics -- v. 5. Therapy and prevention -- v. 6. Future perspectives.
- 2008 Springer Protocolsedited by Meinir G. Jones and Penny Lympany.Understanding of the molecular mechanisms of allergy / Meinir Jones -- T cell : primary culture from peripheral blood / Monika Raulf-Heimsoth -- Production of T-cell lines / Helga Kahlert -- Production of human T-cell clones / Adrienne Verhoef -- Mapping of human T-cell epitopes of allergens / Thomas Zeiler and Tuomas Virtanen -- Determining MHC restriction of T-cell responses / Mark Larché -- Short-term culture of CD8 cells and intracellular cytokine staining / Beejal Vyas and Alistair Noble -- Isolation, flow cytometric analysis, and suppression assay of CD4+ CD25+ T-regulatory cells / Hayley Jeal -- Monocyte-derived dendritic cells as antigen-presenting cells in T-cell proliferation and cytokine production / Sun-sang J. Sung -- Ultrasensitive ELISA for measurement of human cytokine responses in primary culture / William P. Stefura ... [et al.] -- Quantification of human chemokine production in TLR-stimulated and antigen-specific recall responses / Monique Stinson ... [et al.] -- Standardization of allergen extracts / Jørgen Nedergaard Larsen and Sten Dreborg -- Immunoelectrophoresis for the characterization of allergen extracts / Gitte Nordskov Hansen and Jørgen Nedergaard Larsen -- Conjugation of haptens / Ranulfo Lemus and Meryl H. Karol -- Monoclonal antibodies / Helga Kahlert and Oliver Cromwell -- Purification of antibodies / Per H. Larsson -- Collection of air samples to quantify exposure to airborne allergens / Susan Gordon -- Assay of air sample eluates / Anne Renström and Susan Gordon -- The halogen assay : a new technique for measuring airborne allergen / Euan Tovey ... [et al.] -- Measurement of specific IgG anti-Fel d 1 antibodies / Meinir G. Jones -- The facilitated antigen binding (FAB) assay : a protocol to measure allergen-specific inhibitory antibody activity / James N. Francis -- Microscopic identification and purity determination of pollen grains / Magdalena Rahl -- Biopanning for the characterization of allergen mimotopes / Isabella Pali-Schöll and Erika Jensen-Jarolim -- Identification of mast cells and mast cell subpopulations / Mark Buckley and Andrew F. Walls -- Purification and characterization of mast cell tryptase and chymase from human tissues / Alan R. McEuen and Andrew F. Walls -- Experimental activation of mast cells and their pharmacological modulation / Shaoheng He and Andrew F. Walls -- In situ hybridization / Kayhan T. Nouri-Aria.
- 2012 ScienceDirect2011 ClinicalKey[edited by] Stephen T. Holgate, Martin K. Church, David H. Broide, Fernando D. Martinez.The new edition of Allergy, by Drs. Stephen Holgate, Martin Church, David Broide, and Fernando Martinez, uses an enhanced clinical focus to provide the clear, accessible guidance you need to treat allergy patients. A more consistent format throughout features new differential diagnosis and treatment algorithms, updated therapeutic drug information in each chapter, and additional coverage of pediatric allergies. With current discussions of asthma, allergens, pollutants, drug treatment, and more, as well as access to the full text and illustrations online at www.expertconsult.com, this comprehensive resource is ideal for any non-specialist who treats patients with allergies. Prescribe appropriate therapies and effectively manage patients' allergies using detailed treatment protocols. Identify allergic conditions quickly and easily with algorithms that provide at-a-glance assistance. Explore topics in greater detail using extensive references to key literature.
- 2010 Kargervolume editor, Johannes Ring.History and epidemiology -- History and classification of anaphylaxis -- Epidemiology of anaphylaxis -- Mechanisms -- T-cell response to allergens -- Anaphylaxis: mechanisms of mast cell activation -- Kinins, airway obstruction, and anaphylaxis -- Role for basophils in systemic anaphylaxis -- Human cardiac mast cells in anaphylaxis -- Diagnosis and clinical symptomatology -- Mastocytosis -- In vitro diagnosis of anaphylaxis -- Allergens and elicitors -- Insect venoms -- Classification and pathophysiology of radiocontrast media hypersensitivity -- Analgesics -- Anaphylaxis to general anesthetics -- Anaphylactic reactions to local anesthetics -- Treatment and prevention -- Anaphylaxis: acute treatment and management -- Epinephrine (adrenaline) in anaphylaxis.
- 2011 SpringerMariana C. Castells, editor.Definition and criteria for the diagnoses of anaphylaxis -- An epidemiological approach to reducing the risk of fatal anaphylaxis -- Pathophysiology and organ damage in anaphylaxis -- Mast cells: effector cells of anaphylaxis -- Basophils in anaphylaxis -- Protease mediators of anaphylaxis -- Aspirin and NSAID reactions: diagnosis, pathophysiology, and management -- IgE-dependent and independent effector mechanisms in human and murine anaphylaxis -- Food-induced anaphylaxis -- Antibiotic-induced anaphylaxis -- Anaphylaxis during radiological procedures and in the peri-operative setting -- Hymenoptera-induced hypersensitivity reactions and anaphylaxis -- Idiopathic anaphylaxis -- Exercise-induced anaphylaxis and food-dependent exercise-induced anaphylaxis -- Mastocytosis and mast cell activation syndromes presenting as anaphylaxis -- Anaphylaxis in mastocytosis -- Flushing and urticarial syndromes presenting as anaphylaxis -- Pharmacologic management of acute anaphylaxis -- Drug desensitizations in the management of allergy and anaphylaxis to chemotherapeutic agents and monoclonal antibodies -- Rapid desensitizations for antibiotic-induced hypersensitivity reactions and anaphylaxis -- Induction of tolerance for food-induced anaphylaxis -- Management of anaphylaxis: relevance of causes and future trends in treatment.
- 2014 Kargervolume editors: Gianni Marone, Francescopaolo Granata.History of research on angiogenesis -- Immune cells as a source and target of angiogenic and lymphangiogenic factors -- Neuropilins: role in signalling, angiogenesis and disease -- Class 3 semaphorin in angiogenesis and lymphangiogenesis -- Angiogenic and antiangiogenic chemokines -- Role of uPA/uPAR in the modulation of angiogenesis -- Neutrophil-derived cytokines involved in physiological and pathological angiogenesis -- Roles of eosinophils in the modulation of angiogenesis -- Regulatory T cells, leptin and angiogenesis -- Angiogenesis as a therapeutic target for obesity and metabolic diseases -- Angiogenesis in multiple myeloma -- Angiogenesis inhibitors in the treatment of prostate cancer -- Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease.
- 2015 ProQuest Ebook CentralMatthew Smith."To some, food allergies seem like fabricated cries for attention. For others, they pose a dangerous health threat. Food allergies are bound up with so many personal and ideological concerns that it is difficult to determine what is medical and what is myth. This book parses the political, economic, cultural, and genuine health factors of a phenomenon that now dominates our interactions with others and our understanding of ourselves. Surveying the history of food allergy from ancient times to the present, Another Person's Poison also gives readers a clear grasp of new medical findings on allergies and what they say about our environment, our immune system, and the nature of the food we consume. For most of the twentieth century, food allergies were considered a fad or junk science. While many physicians and clinicians argued that certain foods could cause a range of chronic problems, from asthma and eczema to migraines and hyperactivity, others believed that allergies were psychosomatic. Another Person's Poison traces the trajectory of this debate and its effect on public-health policy and the production, manufacture, and consumption of food. Are rising allergy rates purely the result of effective lobbying and a booming industry built on self-diagnosis and expensive remedies? Or should physicians become more flexible in their approach to food allergies and more careful in their diagnoses? Exploring the issue from scientific, political, economic, social, and patient-centered perspectives, this book is the first to engage fully with the history of what is now a major modern affliction, illuminating society's troubled relationship with food, disease, and the creation of medical knowledge."--Book jacket.
- Anti-CD47 antibody-mediated phagocytosis of cancer by macrophages primes an effective anti-tumor T cell response2013Diane Tseng.Mobilization of the T cell response against cancer has the potential to achieve long-lasting cures. However, it is not known how to optimally harness antigen presenting cells to achieve an effective anti-tumor T cell response. In this study, we show that anti-CD47 antibody-mediated phagocytosis of cancer by macrophages can initiate an anti-tumor T cell immune response. Using the ovalbumin model antigen system, anti-CD47 antibody-mediated phagocytosis of cancer cells by macrophages resulted in increased priming of OT-I T cells (CD8+), but did not prime OT-II T cells (CD4+). The CD4+ T cell response was characterized by a reduction in Foxp3+ regulatory T cells. Macrophages following anti-CD47-mediated phagocytosis primed CD8+ T cells to exhibit cytotoxic effector function in vivo, protecting animals from tumor challenge. We conclude that anti-CD47 antibody treatment not only enables macrophage phagocytosis of cancer, but can also initiate an anti-tumor cytotoxic T cell immune response. Anti-CD47-mediated phagocytosis of cancer cells by macrophages leads to priming of a predominant CD8+ T cell response without priming of CD4+ T cells, demonstrating differential priming of T cell responses by macrophages. Priming of effector CD8+ T cells is difficult to achieve with existing vaccines for cancer and infectious diseases. Anti-CD47-based vaccination strategies serve as a promising new strategy for overcoming this challenge for treating or preventing human disease.
- 2012 Springer Protocolsedited by Patrick Chames.1. Use of IMGT® databases and tools for antibody engineering and humanization / Marie-Paule Lefranc, Franc̦ois Ehrenmann, Chantal Ginestoux, Véronique Giudicelli, and Patrice Duroux -- 2. Computer-assisted modeling of antibody variable domains / Oscar H.P. Ramos -- 3. Cloning single-chain antibody fragments (scFv) from hyrbidoma cells / Lars Toleikis and André Frenzel -- 4. Human in-cell scFv library from infiltrating B cell / Sylvie Peraldi-Roux -- 5. Construction of human naive antibody gene libraries / Michael Hust, Andreí Frenzel, Torsten Meyer, Thomas Schirrmann, and Stefan Dübel -- 6. Synthetic customized scFv libraries / Gautier Robin and Pierre Martineau -- 7. Selection of stable scFv antibodies by phage display / Eeva-Christine Brockmann -- 8. Generation of single domain antibody fragments derived from camelids and generation of manifold constructs / Cécile Vincke, Carlos Gutiérrez, Ulrich Wernery, Nick Devoogdt, Gholamreza Hassanzadeh-Ghassabeh, and Serge Muyldermans -- 9. Generation and isolation of target-specific single-domain antibodies from shark immune repertoires / Mischa Roland Müller, Ronan O'Dwyer, Marina Kovaleva, Fiona Rudkin, Helen Dooley, and Caroline Jane Barelle -- 10. Generation of human single domain antibody repertoires by Kunkel mutagenesis / Romain Rouet, Kip Dudgeon, and Daniel Christ -- 11. Phage display and selections on purified antigens / Julie Matz and Patrick Chames -- 12. Phage display and selections on cells / Klervi Even-Desrumeaux and Patrick Chames -- 13. Humanization by CDR grafting and specificity-determining residue grafting / Jin Hong Kim and Hyo Jeong Hong -- 14. Humanization by guided selections / Sang Jick Kim and Hyo Jeong Hong -- 15. Selection of antibody fragments by yeast display / Nathalie Scholler -- 16. Evolution of antibodies in vitro by ribosome display / Bryan M. Edwards and Mingyue He -- 17. Mammalian cell surface display of full length IgG / Chen Zhou and Wenyan David Shen -- 18. Production of antibody fragments in Escherichia coli / Tomohisa Katsuda, Hiroyuki Sonoda, Yoichi Kumada -- 19. Production of antibody derivatives in the methylotrophic yeast Pichia pastoris / Steve Schoonooghe, Jannick Leoen, and Jurgen Haustraete -- 20. Monoclonal antibody expression in mammalian cells / Richard Yi Zhang and Wenyan David Shen -- 21. Production of recombinant antibodies in Drosophila melanogaster S2 cells / Daniel X. Johansson, Thomas Krey, and Oskar Andersson -- 22. Production of antibody fragments using the baculovirus-insect cell system / Takanori Furuta, Takafumi Ogawa, and Hideki Yamaji -- 23. Transient and stable expression of antibodies in Nicotiana species / Freydoun Garabagi, Michael D. McLean, and J. Christopher Hall -- 24. Measuring antibody-antigen binding kinetics using surface plasmon resonance / Stephen Hearty, Paul Leonard, and Richard O'Kennedy -- 25. Affinity determination of biotinylated antibodies by flow cytometry / Klervi Even-Desrumeaux and Patrick Chames -- 26. Affinity maturation of antibodies : optimized methods to generate high-quality scFv libraries and isolate IgG candidates by high-throughput screening / Laurence Renaut, Céline Monnet, Olivier Dubreuil, Ouafa Zaki, Fabien Crozet, Khalil Bouayadi, Hakim Kharrat, and Philippe Mondon -- 27. Affinity maturation by semi-rational approaches / Rodrigo Barderas, Johan Desmet, Philippe Alard, and J. Ignacio Casal -- 28. Molecular scanning : combining random mutagenesis, ribosome display, and bioinformatic analysis for protein engineering / Alfredo Darmanin-Sheehan, William James Jonathan Finlay, Orla Cunningham, and Brian Joseph Fennell -- 29. Fucose-targeted glycoengineering of pharmaceutical cell lines / Christiane Ogorek, Ingo Jordan, Volker Sandig, and Hans Henning von Horsten -- 30. Fc engineering : design, expression, and functional characterization of antibody variants with improved effector function / Stefanie Derer, Christian Kellner, Sven Berger, Thomas Valerius, and Matthias Peipp -- 31. Fc engineering : serum half-life modulation through FcRn binding / Tove Olafsen -- 32. Monoclonal antibody lead characterization : in vitro and in vivo methods / Axel Hernandez, Julie Parmentier, Youzhen Wang, Jane Cheng, and Gadi Gazit Bornstein -- 33. Production, purification, and characterization of scFv TNF ligand fusion proteins / Andrea Fick, Agnes Wyzgol, and Harald Wajant --34. Antibody-IL2 fusion proteins for tumor targeting / Andreas A. Hombach and Hinrich Abken -- 35. Recombinant immunotoxins with low endotoxins for clinical and animal studies / Masanori Onda -- 36. Chimeric antigen receptors for T-cell based therapy / Eleanor J. Cheadle, Vicky Sheard, Andreas A. Hombach, Markus Chmielewski, Tobias Riet, Cor Berrevoets, Erik Schooten, Cor Lamers, Hinrich Abken, Reno Debets, and David E. Gilham -- 37. Selection and use of intracellular antibodies (intrabodies) / Sandrine Moutel, Clément Nizak, and Franck Perez -- 38. Radiolabeled antibodies for cancer imaging and therapy / Jacques Barbet, Manuel Bardiès, Mickael Bourgeois, Jean-Franc̦ois Chatal, Michel Chérel, Franc̦ois Davodeau, Alain Faivre-Chauvet, Jean-Franc̦ois Gestin, and Franc̦oise Kraeber-Bodéré -- 39. Design and production of multimeric antibody fragments, focused on diabodies with enhanced and clinical efficacy / Glenn A. Powers, Peter J. Hudson, and Michael P. Wheatcroft -- 40. Production of bispecific antibodies : diabodies and tandem scFv / Nora Hornig and Aline Färber-Schwarz.
- v. 1-2, 2010. Springerv. 2, 2010 SpringerRoland Kontermann, Stefan Dübel (editors).
- 2014 ScienceDirectMargaret E. Ackerman, Falk Nimmerjahn.Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.
- 2012 Springer Protocolsedited by Gabriele Proetzel, Hilmar Ebersbach.Antigen presentation for the generation of binding molecules / Hilmar Ebersbach, Gabriele Proetzel, and Chonghui Zhang -- Recombinant antibodies and in vitro selection technologies / C. Ronald Geyer [and others] -- Phage display / Konstantin Petropoulos -- Generation of human fab libraries for phage display / Christoph Rader -- Selection of human fab libraries by phage display / Christoph Rader -- Ribosome Display / George Thom and Maria Groves -- Hybridoma technology for the generation of monoclonal antibodies / Chonghui Zhang -- Application of transgenic mice for therapeutic antibody discovery / E-Chiang Lee and Michael Owen -- Production of human or humanized antibodies in mice / Brice Laffleur [and others] -- Immortalization of human B cells : analysis of B cell repertoire and production of human monoclonal antibodies / Elisabetta Traggiai -- Kinetic screening in the antibody development process / Michael Schraml and Matthias Biehl -- Temperature-dependent antibody kinetics as a tool in antibody lead selection / Michael Schraml and Leopold von Proff -- Determination of antibody glycosylation by mass spectrometry / Christiane Jager [and others] -- Cloning, expression, and purification of monoclonal antibodies in scFv-Fc format / Jiahui Yang and Christoph Rader -- PEGylation of antibody fragments for half-life extension / Simona Jevsevar, Mateja Kusterle, and Maja Kenig -- Bispecific antibody derivatives based on full-length IgG formats / Michael Grote [and others] -- Generation of fluorescent IgG fusion proteins in mammalian Cells / Alexander K. Haas, Klaus Mayer, and Ulrich Brinkmann -- Methods to engineer and identify IgG1 variants with improved FcRn binding or effector function / Robert F. Kelley and Y. Gloria Meng -- Class-specific effector functions of therapeutic antibodies / Virginie Pascal, Brice Laffleur, and Michel Cogne.
- 2012 SpringerPaul Kosma, Sven Müller-Loennies, editors.Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. ãaAnticarbohydrate Antibodies ãa from molecular basis to clinical applicationãa compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
- 2013 Springer Protocolsedited by Peter van Endert.Purification of large cytosolic proteases for in vitro assays: 20S and 26S proteasomes -- Analysis of proteasome generated antigenic peptides by mass spectrometry -- Using protease inhibitors in antigen presentation assays -- Kinetic studies of cytoplasmic antigen processing and production of MHC class I ligands -- Assaying peptide translocation by the peptide transporter TAP -- In vitro reconstitution of the MHC class I peptide-loading complex -- Studying mhc class i peptide loading and exchange in vitro -- Measuring synthesis and degradation of MHC class I molecules -- Studying ubiquitination of MHC class I molecules -- Evaluation of viral interference with MHC class I-restricted antigen processing and presentation using a flow cytometry-based approach -- Determining the activity of the transporter associated with antigen processing in the compartments of the secretory pathway -- Biochemical large-scale identification of MHC class I ligands -- Establishing MHC class I peptide motifs -- Quantitating MHC class I ligand production and presentation using TCR-like antibodies -- Biochemical analysis of naturally processed antigenic peptides presented by MHC class I molecules -- Identifying source proteins for MHC class I-presented peptides -- Purification, preparation, and use of chaperone-peptide complexes for tumor immunotherapy -- Recombinant poxviruses: Versatile tools for immunological assays -- Bioinformatics identification of antigenic peptide: Predicting the specificity of major MHC class I and II pathway players -- Evaluating CD8(+) T cell responses in vitro -- Cloning CD8(+) cytolytic T lymphocytes -- Production of CD4(+) and CD8 (+) T cell hybridomas -- Tracking antigen-specific CD8(+) T cells using MHC class I multimers -- The purification of large numbers of antigen presenting dendritic cells from mouse spleen -- Preparation of dendritic cells by in vitro cultures -- Monitoring dendritic cell activation and maturation -- Monitoring the intracellular routing of internalized antigens by immunofluorescence microscopy -- Isolation of a specialized, antigen-loaded early endosomal subpopulation by flow cytometry -- Preparing antigens suitable for cross-presentation assays in vitro and in vivo -- Gene transduction in human monocyte-derived dendritic cells using lentiviral vectors -- Pulse-chase analysis for studies of MHC class II biosynthesis, maturation, and peptide loading -- Assembly of matched [alpha/beta] subunits to HLA class II peptide receptors -- Studying MHC class II peptide loading and editing in vitro -- Study of the allogeneic response induced by endothelial cells expressing hla class ii after lentiviral transduction -- Antigen processing for mhc presentation via macroautophagy -- Studying MHC class II transport in dendritic cells -- In vitro digestion with proteases producing MHC class II ligands -- MHC-II ubiquitination -- Studying MHC class II presentation of immobilized antigen by B lymphocytes -- Production of primary human CD4(+) T cell lines and clones -- Analyzing antigen recognition by natural killer T cells -- Chromatofocusing purification of CD1B-antigen complexes and their analysis by isoelectric focusing.
- 2016 SpringerJürgen Harder, Jens-M. Schröder, editors.Antimicrobial peptides in cutaneous wound healing -- Antimicrobial peptides as endogenous antibacterials and antivirals at the ocular surface -- Function of antimicrobial peptides in lung innate immunity -- Role of antimicrobial peptides to prevent infections in the kidney and urinary tract -- Antimicrobial peptides in the gut -- Metal sequestration: An important contribution of antimicrobial peptides to nutritional immunity -- Regulation of antimicrobial peptide gene expression by vitamin D -- Dichotomous roles of cationic polypeptides targeting HIV -- Antimicrobial peptides in host-defense: functions beyond antimicrobial activity.
- 2013 Springeredited by Pieter S. Hiemstra, Sebastian A.J. Zaat.Evolution of Antimicrobial Peptides: A View from the Cystine Chapel -- Innate Immunity in Plants: The Role of Antimicrobial Peptides -- Antimicrobial Peptides Produced by Microorganisms -- LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide -- Wound Repair and Antimicrobial Peptides -- WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2 -- Histatins: Multifunctional Salivary Antimicrobial Peptides -- Structure-Function Relationships of Antimicrobial Chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial Peptides and Inflammatory Bowel Disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial Peptides in Chronic Obstructive Pulmonary Disease -- Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo -- Helping the Host: Induction of Antimicrobial Peptides as a Novel Therapeutic Strategy Against Infections.
- 2015 SpringerPier Luigi Meroni, editor.This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss or complications are explained. The main clinical manifestations and classification criteria are described and diagnostic tools, identified. Close attention is paid to the nature of the involvement of other organs or organ systems in APS, including the nervous, endocrine, hematologic, cardiovascular, and gastrointestinal systems, the kidney, the skin, and the eye. Specific chapters describe the treatment of the different symptoms, the preventive therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome
- Antiphospholipid syndrome : insights and highlights from the 13th International Congress on Antiphospholipid Antibodies2012 SpringerDoruk Erkan, Silvia S. Pierangeli, editors.Part 1. History of Antiphospholipid Syndrome -- 1. Overview of the Last 25 Years and 13 International Congresses on Antiphospholipid Antibodies / Eon Nigel Harris and Silvia S. Pierangeli -- Part II. Basic Science Aspects of Antiphospholipid Syndrome -- 2. What is the Oirgin of Antiphospholipid Antibodies? / Rohan Willis, Yehuda Shoenfeld, Silvia S. Pierangeli and Miri Blank -- 3. What is the Genetics of Antiphospholipid Antibodies/Syndrome? / Thomas L. Ortel, Pier Luigi Meroni, Marta E. Alarcón-Riquelme, Maria O. Borghi and Joan T. Merrill -- 4. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Thrombosis? / Rohan Willis, Ian P. Giles, Pojen P. Chen, Chary López-Pedrera and María José Cuadrado, and Silvia S. Pierangeli -- 5. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity? / Vikki M. Abrahams, Maria O. Borghi, Pier Luigi Meroni, Jacob H. Rand, Elena Raschi, Jane E. Salmon, Francesco Tedesco, and Angela Tincani -- 6. What are the Target Cells and Receptors that are Recognized by Antiphospholipid Antibodies? / Philip G. de Groot, Elena Raschi, Keith R. McCrae, Silvia S. Pierangeli, Panayiotis G. Vlachoyiannopoulos, and Rolf T. Urbanus -- Part 3. 13th Iinternational Congress on Antiphospholid Antibodies Task Force Reports -- 7. Task Force Report on "Criteria" Antiphospholipid Antibody Tests / Robert A. S. Roubey and Silvia S. Pierangeli -- 8. Task Force Report on "Non-criteria" Antiphospholipid Antibody Tests / Maria Laura Bertolaccini, Olga Amengual, Tatsuya Atsumi, Walter L. Binder, William H. Kutteh, Bas de Laat, [and others] -- 9. Task Force Report on Obstetric Antiphospholipid Syndrome / D. Ware Branch, Benjamin Leader and Carl A. Laskin -- 10. Task Force Report on Brain Involvement in Antiphospholipid Syndrome / Joab Chapman, Eyal Muscal and Robin L. Brey -- 11. Task Force Report on the Management of Thrombosis in Antiphospholipid Syndrome / Guillermo Ruiz-Irastorza, Vittorio Pengo, Maria G. Tektonidou, Ioana Ruiz-Arruza, María José Cuadrado, and Munther A. Khamashta -- 12. Task Force Report on Catastrophic Antiphospholipid Syndrome / Gerard Espinosa, Horacio Berman, Doruk Erkan and Ricard Cervera -- 13. Task Force Report on Non-criteria Manifestations: Thrombocytopenia / Gabriela Hernández-Molina, Xavier López-Karpovitch, Emilio B. González and Antonio R. Cabral -- 14. Task Force Report on Non-criteria Manifestations: Nephropathy / Maria G. Tektonidou, Horacio E. Adrogué and Smita Vaidya -- 15. Task Force Report on Non-criteria Manifestations: Cardiac Valve Disease / Gerard Espinosa, Lucía Fernández de Orueta, Elena Lluch, María Ángeles Polvorosa, Sandra Soro, and Ricard Cervera -- 16. Task Force Report on Non-criteria Manifestations: Skin / Michal Solomon, Yehuda Shoenfeld and Gisele Zandman-Goddard -- 17. Task Force Report on Antiphospholipid Syndrome Clinical Research / Doruk Erkan, Silvia S. Pierangeli and Michael D. Lockshin -- Part 4. Future of Antiphospholipid Syndrome -- 18. What are the Potential Future Treatments in Antiphospholipid Syndrome? / Doruk Erkan, Anisur Rahman, Hannah Cohen, Samuel J. Machin and Silvia S. Pierangeli -- 19. Remembrances of Predictions Past / Michael D. Lockshin -- Part 5. Antiphospholipid Syndrome for Patients -- 20. What Should Patients Know about Antiphospholipid Antibodies and Antiphospholipid Syndrome? / Doruk Erkan, Lindsay Lally and Michael D. Lockshin.
- 2010 SpringerMarie Laura Bertolaccini, Oier Ateka-Barrutia, and Munther A. Khamashta.History / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Epidemiology / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Antiphospholipid Antibodies / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Classification Criteria for APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Mortality, Morbidity, and Damage Associated with aPL / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differences Between Primary and Secondary APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Clinical Features / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- aPL and Transplantation / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differential Diagnosis / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Management of APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta.
- 2017 ScienceDirectedited by Ricard Cervera, Gerard Espinosa, Munther Khamashta.Antiphospholipid Syndrome in Systemic Autoimmune Diseases, Second Edition provides an overview of our current understanding of this major disease. It includes the latest information on the new pathogenetic mechanisms involved, along with clinical manifestations in both the thrombotic and non-thrombotic manifestations of this important disease. Antiphospholipid syndrome is an autoimmune disease that causes abnormal blood clots. It is now recognized as a major cause of common conditions, including stroke, heart attack, miscarriage, epilepsy, and memory loss, and as such is gaining recognition in all branches of medicine, from obstetrics to cardiology, and from psychiatry to orthopedics.
- 2009 ScienceDirectedited by Ricard Cervera, Joan Carles Reverter, Munther Khamashta.
- Artificial immune systems : 7th International Conference, ICARIS 2008, Phuket, Thailand, August 10-13, 2008 : proceedings2008 SpringerPeter J. Bentley, Doheon Lee, Sungwon Jung (eds.).
- 2012Audrie Lin.Overview: 555 million preschool children live in developing countries where malnutrition (undernutrition) is a significant problem. The factors that contribute to this issue are multiple, with two important factors being gut microbiota and gut function. To begin to understand gut microbiota and gut function in a developing country, we performed two parallel studies: in the first study, we characterized the baseline gut microbiota of healthy Bangladeshi children, and in the second study, we investigated the association between household environmental conditions and gut function in Bangladeshi children. The gut microbiota affect nutrient metabolism, immune function, and pathogen resistance. Loss of gut function as occurs in environmental enteropathy (a multifaceted, subclinical intestinal disorder likely derived from repeated episodes of infectious gastroenteritis and chronic inflammation) contributes to malnutrition and growth faltering. It is possible that these processes are interrelated with the gut microbiota serving a critical role in environmental enteropathy. Gut microbiota: Previous studies have focused on the gut microbiota of infants and adults from developed countries, but few have characterized the gut microbiota of people living in developing countries. Furthermore, little is known about the gut microbiota and its variation over time in primary-school-age children and adolescents in either developed or developing countries. In this study, we compared the monthly variation in fecal microbiota composition of healthy children (ages 8--14 years) living in an urban slum in Bangladesh with that of age-matched children from affluent suburban communities in the United States. We analyzed 8,000 near full-length sequences of the small-subunit ribosomal RNA gene (16S rDNA) and over 845,000 pyrosequencing reads spanning the V1-V3 variable region of the 16S rDNA. The distal gut of Bangladeshi children harbored significantly higher microbial diversity than U.S. children, a result validated by the discovery of several novel lineages from various bacterial phyla in the full-length Bangladeshi dataset. Bangladeshi and U.S. children displayed distinct gut microbiota architectures. Moreover, significantly lower month-to-month temporal stability was observed in Bangladeshi children compared to U.S. children. Together, these results suggest that different environmental or genetic variables may affect the microbiota of healthy children in the two countries. Further studies are necessary to investigate the underlying mechanisms of these differences and to incorporate these insights into prevention or treatment of diseases. Gut function: Although poor water quality, sanitation, and hygiene are putative risk factors for environmental enteropathy, there are no studies investigating the relationship of household environmental conditions to environmental enteropathy. We compared levels of environmental enteropathy markers to growth patterns and measured the prevalence of parasitic infections in children living in different levels of environmental cleanliness based on indictors of water, sanitation, and hygiene in their households. We conducted a follow-up study of 119 children (< 4 years old) from an existing cohort, living in rural Bangladesh and divided into two types of households: a 'mitigated household' had good water quality, improved sanitation, and a handwashing station stocked with water and soap, and a 'contaminated household' had poor water quality, and inadequate sanitation and handwashing facilities. We measured anthropometry, intestinal parasitic infection, and the following markers to assess gut function: Lactulose:Mannitol (L:M) ratio, immunoglobulin G endotoxin core antibody (IgG EndoCAb), and total IgG. After adjustment for potential confounding, children from mitigated households had higher height-for-age Z-scores (HAZ), lower L:M ratios, and lower IgG EndoCAb titers than children from contaminated households. The L:M ratio was also strongly associated with HAZ in the cohort. Children living in environmentally mitigated households had lower levels of parasitic infection, improved measures of gut function, and improved growth compared to children living in contaminated environments. These results support the hypothesis that environmental contamination mediated through environmental enteropathy could be a cause of growth faltering in low-income countries. Interpretation: By characterizing the baseline gut microbiota of healthy children living in a developing country and correlating their gut function with household environmental conditions, our work provides a foundation to address the role of the gut microbiota and environmental enteropathy in child health.
- 2008 Springereditor, Mikhail V. Kiselevsky.
- 2010 CRCnetBASEJulius M. Cruse, Robert E. Lewis.History of immunology -- Molecules, cells, and tissues of the immune response -- Antigens and immunogens -- Major histocompatibility complex -- Antigen processing and presentation -- B lymphocyte development and immunoglobulin genes -- Immunoglobulin synthesis, properties, structure, and function -- Antigen-antibody interactions -- The thymus and T lymphocytes -- Cytokines and chemokines -- The complement system -- Types I, II, III, and IV hypersensitivity -- Immunoregulation and immunologic tolerance -- Autoimmunity -- Mucosal immunity -- Immunohematology -- Immunological diseases and immunopathology -- Immunophenotyping of hematopoietic malignancies -- Immunodeficiencies: congenital and acquired -- Acquired immune deficiency syndrome (AIDS) -- Immunomodulators -- Transplantation immunology -- Tumor immunology -- Immunity against microorganisms -- Vaccines and immunization -- Therapeutic immunology -- Comparative immunology -- Immunological methods and molecular techniques -- Diagnostic immunohistochemistry.
- 2013 SpringerRoberto N. Miranda, Joseph D. Khoury, L. Jeffrey Medeiros.Atlas of Lymph Node Pathology reviews the histopathology of nodal diseases, illustrating the use of ancillary studies and includes concise discussions of pathogenesis, clinical settings and clinical significance of the pathologic diagnosis. The atlas features an overview of the benign reactive processes secondary to infectious, environmental or unknown insults, as well as relevant illustrations of virtually all primary and secondary neoplasms involving lymph nodes. The atlas also includes macroscopic images of some disorders, tables that help readers understand and comprehend diseases that look alike, and diagnostic algorithms for certain groups of diseases. Authored by highly experienced pathologists, Atlas of Lymph Node Pathology is a valuable resource that illustrates the vast majority of diseases practicing pathologists, clinicians and oncologists are likely to encounter in daily practice.
- 2013 SpringerDennis P. O'Malley.1. Normal Morphologic and Immunohistochemical Findings and Hyperplasias -- 2. Congenital Malformations and Abnormalities of Spleen Location and Histology -- 3. Lmphoid Neoplasms -- 4. Myeloid and Related Disorders -- 5. Nonhematopoietic Lesions Including Vascular -- 6. Reactive and Systemic Conditions -- 7. Infections.
- 2011 Kargervolume editors, Thomas Werfel, Jonathan M. Spergel, Wieland Kiess.Atopic dermatitis is amongst the most common disorders of the skin in young people around the world. This book presents the newest insights and novel concepts in relation to all aspects of this skin disorder. Classification, clinical features and differential diagnosis are reviewed in the first chapter, while risk factors, susceptibility and an epidemiological overview are outlined in the next chapter, followed by a detailed discussion of the immunology of the skin and the pathophysiology of dermatitis. Further chapters present new data delineating clinical aspects of current genetic findings and insights into concepts of neuroimmunology, as well as the very crucial and severe clinical aspect of itching. New data on the topic of inhalant allergy, specific immunologic treatments and the latest on food allergy are also included.
- ATP-dependent chromatin remodeling BRG/Brahma-associated factors (BAF) complexes in the regulation of mammalian stem cell self-renewal and development2010Lena Wai Mun Ho.Mammalian SWI/SNF (also called BAF) ATP-dependent chromatin remodeling complexes are essential for formation of the pluripotent cells of the early embryo, and are also crucial for the self-renewal and pluripotency of mouse embryonic stem cells (ESCs). To understand the molecular mechanism of BAF complexes in regulating the chromatin of pluripotent stem cells, we performed both proteomic and genomic studies of endogenous complexes in ESCs. Proteomic studies reveal that ESCs express distinctive BAF complexes (esBAF), and this specialized subunit composition is required for ESC maintenance and pluripotency. High-resolution genome-wide mapping of the core ATPase subunit, Brg, using ChIP-Seq technology indicates that esBAF is a core component of the pluripotent transcriptional network. This is consistent with findings that esBAF interacts both physically and genetically with key regulators of pluripotency such as Stat3, Oct4 and Sox2. In addition, esBAF is critical for Stat3-mediated gene activation and repression in mESCs in response to Leukemia Inhibitory Factor (LIF), the cytokine that maintains mESCs in a self-renewing state. Brg maintains open accessibility of Stat3 target sites to allow continuous binding of Stat3 in response to LIF signaling, and prevents the expansion of Polycomb activity and the inappropriate deposition of the silencing mark H3K27me3 at both Stat3 targets and other sites. We propose that one integral mechanism of esBAF action in maintaining pluripotency is to maintain Stat3 responsiveness in ESCs by regulating the accessibility of its target sites. The role of BAF complexes in self-renewal and differentiation extend to adult multipotent stem cells. Using mouse adult hematopoietic development as a model, we show that Brg is required for the transition of quiescent long-term hematopoietic stem cells (LT-HSCs) to their downstream progenitors, and for the multilineage differentiation of transit amplifying hematopoietic progenitors. Hence, we propose that chromatin remodeling is generally required for the function and maintenance of stem cells by the regulation of their specialized chromatin landscape.
- 2010 CRCnetBASEedited by Abha Chauhan, Ved Chauhan, W. Ted Brown.Type, topography, and sequelae of neuropathological changes shaping clinical phenotype of autism / Jerzy Wegiel ... [et al.] -- Evidence for oxidative damage in the autistic brain / Teresa A. Evans ... [et al] -- Oxidative stress and neurotrophin signaling in autism / Elizabeth M. Sajdel-Sulkowska -- Genetics of autism / W. Ted Brown -- The phenotypic expression of autism, maternal depression, and the monoamine oxidase-a gene / Ira L. Cohen -- Paraoxonase 1 status, environmental exposures, and oxidative stress in autism spectrum disorders / Maria Dronca and Sergiu P. Pasca -- The redox/methylation hypothesis of autism : a molecular mechanism for heavy metal-induced neurotoxicity / Richard C. Deth -- Autism and oxidative stress : evidence from an animal model / Michelle A. Cheh ... [et al.] -- Neurotoxic brainstem impairment as proposed threshold event in autistic regression / Woody R. McGinnis ... [et al.] -- Abnormalities in membrane lipids, membrane-associated proteins, and signal transduction in autism / Ved Chauhan and Abha Chauhan -- Mitochondrial component of calcium signaling abnormality in autism / J. Jay Gargus -- Inflammation and neuroimmunity in the pathogenesis of autism : neural and immune network interactions / Carlos A. Pardo-Villamizar and Andrew W. Zimmerman -- Possible impact of innate immunity on autism / Harumi Jyonouchi -- Autism, gastrointestinal disturbance, and immune dysfunction : what is the link? / Paul Ashwood, Amanda Enstrom, and Judy van de Water -- Possible mechanism involving intestinal oxytocin, oxidative stress, and signaling pathways in a subset of autism with gut symptoms / Martha G. Welch and Benjamin Y. Klein -- Cytokine polymorphisms in autism : their role in immune alterations / Fabián Crespo ... [et al.] -- Autism, teratogenic alleles, HLA-DR4, and immune function / William G. Johnson ... [et al.] -- Autism : the centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy / Martha R. Herbert -- A re-evaluation of the state of autism treatment : the need for a biopsychosocial perspective / Eric London.
- 2016 SpringerNaveed Sami, editor.Bullous pemphigoid -- Epidermolysis Bullosa Acquisita -- Linear IgA Bullous Disease -- Dermatitis Herpetiformis -- Bullous pemphigoid -- Epidermolysis Bullosa Acquisita -- Linear IgA Bullous Disease -- Dermatitis Herpetiformis -- Pemphigoid Gestationis -- Pediatric Bullous Diseases -- Pemphigus Vulgaris -- Pemphigus Foliaceus -- Ocular Cicatricial Pemphigoid -- Mucous Membrane Pemphigoid (extra ocular) -- Local therapy -- Systemic Steroids -- Pemphigoid Gestationis.
- 2016 SpringerMarcel F. Jonkman, editor.Part I: Immunology and diagnostic tests-B-cells, autoantibodies and isotypes -- Dermatological examination of bullous diseases -- How to take a biopsy -- Direct immunofluorescence -- Indirect immunofluorescence -- Immunoblot -- ELISA testing -- Part II: Pemphigus-Structure of desmosomes -- Pemphigus foliaceus -- Pemphigus vulgaris -- Paraneoplastic pemphigus -- IgA pemphigus -- Part III: Pemphigoids-Structure of hemidesmosomes and basement membrane zone -- Cutaneous pemphigoid -- Mucous membrane pemphigoid -- Epidermolysis bullosa acquisita -- Bullous systemic lupus erythematosus -- Linear IgA Disease -- Part IV: Other inflammatory bullous diseases-Dermatitis herpetiformis -- Erythema multiforme -- Porphyria and pseudoporphyria -- Bullous dermatitis artefacta -- Part V: Resources-Patient support groups -- International centres for AIBD.
- Autoimmune disease : pathogenesis, genetics, immunotherapy, prophylaxis and principles for organ transplantation2013 SpringerDuncan Dartrey Adams, Christopher Dartrey Adams.This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
- 2011 SpringerMunther A. Khamashta, Manuel Ramos-Casals (editors).Assessment and Management of the Rheumatological Patient in the Critical Care Unit -- Life-Threatening Complications of Systemic Lupus Erythematosus -- Catastrophic Antiphospholipid Syndrome -- Complex Situations in Rheumatoid Arthritis -- Sjögren's Syndrome: Beyond Sicca Involvement -- Systemic Sclerosis: Severe Involvement of Internal Organs -- Vasculitic Emergencies in Patients with Large-Vessel Vasculitis -- Life-Threatening Presentations of ANCA-Associated Vasculitis -- Severe Polyarteritis Nodosa -- Life-Threatening Cryoglobulinemia -- Behçets Syndrome: Clinical Presentations Affecting Prognosis and Survival -- Myositis: When Weakness Can Kill -- Complicated Sarcoidosis: Challenges in Dealing with Severe Manifestations -- Complex Situations in Patients with Adult-Onset Still's Disease -- Managing Acute and Complex Dermatological Situations -- Life-Threatening Autoimmune Hematological Disorders -- Autoimmune Ear, Nose, and Throat Emergencies -- Ophthalmological Emergencies in Rheumatic and Autoimmune Diseases -- Emergencies for the Vascular Surgeon -- Complicated Pregnancies in Patients with Autoimmune Systemic Diseases -- The Complex Management of Viral-Related Autoimmune Diseases -- The Role of Intravenous Immunoglobulins in the Management of Acute Complex Autoimmune Conditions -- Life-Threatening Complications of Biological Therapies.
- 2014 ScienceDirect2014 ClinicalKeyedited by Noel Richard Rose, Ian R. MacKay.
- 2011 SpringerMichael Hertl (ed.).Pathogenesis of autoimmune diseases / Martin Röcken and Tilo Biedermann -- Autoantibody detection using indirect immunofluorescence on HEp-2 cells / Philipp von Landenberg -- Pemphigus / Michael Hertl and Rüdiger Eming -- Bullous pemphigoid : clinical features, diagnostic markers, and immunopathogenic mechanisms / Giovanni Di Zenzo ... [et al.] -- Dermatitis herpetiformis duhring / Christian Rose and Detlef Zillikens -- Epidermolysis bullosa acquisita / Gene Kim ... [et al.] -- Localized scleroderma / Cristián Vera Kellet, Catherine H. Orteu, and Jan P. Dutz -- Progressive systemic scleroderm / Nicolas Hunzelmann and Thomas Krieg -- Chronic cutaneous lupus erythematosus / Michael Sticherling -- Subacute cutaneous and systemic lupus erythematosus / Donna M. Pellowski, Jane E. Kihslinger, and Richard D. Sontheimer -- Dermatomyositis / Ruth Ann Vleugels and Jeffrey P. Callen -- Mixed connective tissue disease / Reiji Kasukawa -- Sjögren's Syndrome / Robert I. Fox and Carla M. Fox -- Psoriasis vulgaris and arthopathica / Arnd Jacobi and Jörg Christoph Prinz -- Chronic urticaria as an autoimmune disease / Clive Grattan, Michihiro Hide, and Malcolm W. Greaves -- Lichen planus, lichenoid eruptions and cutaneous grant-versus-host-reaction / Miklós Simon, Jr. -- Small vessel vasculitides / Peter Lamprecht and Wolfgang L. Gross -- Skin manifestations of rheumatic diseases / Camille Francés and Nicolas Kluger -- Vitiligo / Karin U. Schallreuter -- Alopecia areata / Pia Freyschmidt-Paul, Kevin McElwee, and Rolf Hoffmann -- Autoimmune phenomena in atopic dermatitis / Caroline Bussmann and Natalija Novak -- Eosinophils in autoimmune bullous diseases / Dagmar Simon and Hans-Uwe Simon -- Paraneoplastic syndromes of the skin / Peter Fritsch -- Targeted therapies in autoimmune and inflammatory skin disorders / Rüdiger Eming and Ingo H. Tarner.
- 2014 SpringerHiromasa Ohira, editor.Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
- 2015 SpringerTerumi Kamisawa, Jae Bock Chung, editors.This book provides up-to-date information on all aspects of autoimmune pancreatitis, a unique form of pancreatitis characterized clinically by frequent presentation with obstructive jaundice and dramatic response to steroids, histologically by a lymphoplasmacytic infiltrate with fibrosis, and radiologically by pancreatic enlargement. Current concepts regarding the disease and its classification into subtypes 1 and 2 are explained, and clinical, serological, and histopathological findings are carefully described. Imaging features on all the relevant modalities are illustrated, covering both the pancreas and other involved organs. Current and emerging therapeutic strategies, including steroids, immunomodulatory drugs, and rituximab, are then discussed. The reader will find the book to be an excellent aid to the diagnosis of autoimmune pancreatitis and its differentiation from pancreatobiliary malignancies, as well as a clear guide to treatment.
- 2012 Springer Protocolsedited by Andras Perl.Pathogenesis and spectrum of autoimmunity / Andras Perl -- Mapping susceptibility gene in systemic lupus erythematosus / R. Hal Scofield and Kenneth M. Kaufman -- Methods and protocols to study T cell signaling abnormalities in human systemic lupus erythematosus / Vaishali R. Moulton, Mindy S. Lo, and George C. Tsokos -- Assessment of mitochondrial dysfunction in lymphocytes of patients with systemic lupus erythematosus / Andras Perl, Robert Hanczko, and Edward Doherty -- Role of endocytic recycling in autoimmunity / Tiffany Telarico and Andras Perl -- Multiparameter flow cytometry and bioanalytics for B cell profiling in systemic lupus erythematosus / Denise A. Kaminski [and others] -- Experimental use of mouse models of systemic lupus erythematosus / Stanford L. Peng -- Murine models of lupus induced by hypomethylated T cells (DNA hypomethylation and lupus ...) / Bruce Richardson [and others] -- Aspects of CNS lupus : mouse models of anti-NMDA receptor antibody mediated reactivity / Czeslawa Kowal and Betty Diamond -- Analysis of renal mononuclear phagocytes in murine models of SLE / Ramalingam Bethunaickan, Ranjit Sahu, and Anne Davidson -- Murine autoimmune model of rheumatoid arthritis and systemic lupus erythematosus associated with deregulated production of IL-17 and IL-21 / Partha S. Biswas [and others] -- Parent-into-F1 murine model in the study of lupus-like autoimmunity and CD8 cytotoxic T lymphocyte function / Kateryna Soloviova [and others] -- Genetic approach to study lupus glomerulonephritis / Yan Ge [and others] -- Animal models of primary biliary cirrhosis : materials and methods / Patrick S.C. Leung [and others] -- Modeling innate immunity in murine skin : utilization of subcutaneous osmotic pumps for inflammatory and fibrotic skin disease / Michael Dimarzio, Giuseppina Farina, and Robert Lafyatis -- Flow cytometric identification of fibrocytes in scleroderma lung disease / Thomas M. Russell, Erica L. Herzog, and Richard Bucala -- Oxidative stress and beta cell dysfunction / Yaima L. Lightfoot, Jing Chen, and Clayton E. Mathews -- Experimental autoimmune encephalomyelitis / Praveen Rao and Benjamin M. Segal -- Mouse models of multiple sclerosis : experimental autoimmune encephalomyelitis and theiler's virus-induced demyelinating disease / Derrick P. McCarthy, Maureen H. Richards, and Stephen D. Miller -- Pathogenesis of multiple sclerosis : what can we learn from the cuprizone model / Peter Acs and Bernadette Kalman -- Assessing inflammatory disease at mucosal surfaces in murine genetic models / R.W. Engelman and William G. Kerr -- Rodent models of experimental autoimmune uveitis / Rajeev K. Agarwal, Phyllis B. Silver, and Rachel R. Caspi -- Tolerance induction via B-cell delivered gene therapy / Robert J. Rossi [and others].
- 2008 Springer Protocolsedited by Vojo Deretic.Autophagosome and phagosome / V. Deretic -- Fine structure of the autophagosome / E.L. Eskelinen -- Methods for assessing autophagy and autophagic cell death / E. Tasdemir ... [et al.] -- LC3 and Autophagy / I. Tanida, T. Ueno and E. Kominami -- Amino Acid regulation of autophagosome formation / A.J. Meijer -- Autophagic proteolysis of long-lived proteins in nonliver cells / E.A. Roberts and V. Deretic -- Autophagosomes in GFP-LC3 Transgenic Mice / N. Mizushima and A. Kuma -- Experimental control and characterization of autophagy in Drosophila / G. Juhasz and T.P. Neufeld -- Analysis of autophagosome membrane cycling by fluorescence microscopy / J.E. Legakis and D.J. Klionsky -- Protein trafficking into autophagosomes / A. Young and S. Tooze -- Sphingolipids in macroautophagy / G. Lavieu ... [et al.] -- Molecular links between autophagy and apoptosis / I.A. Ciechomska, C.G. Goemans and A.M. Tolkovsky -- Clearance of mutant aggregate-prone proteins by autophagy / B. Ravikumar, S. Sarkar and D.C. Rubinsztein -- Localization and MHC Class II Presentation of Antigens Targeted for Macroautophagy / D. Schmid and C. Munz -- Chaperone-mediated autophagy / S. Kaushik and A.M. Cuervo -- Microautophagy in the Yeast Saccharomyces cerevisiae / A. Uttenweiler and A. Mayer -- EM Analysis of Phagosomes / C. de Chastellier -- Analysis of phosphoinositide dynamics during phagocytosis using genetically encoded fluorescent biosensors / G. Cosio and S. Grinstein -- In vitro phagosome-endosome fusion / I. Vergne and V. Deretic -- Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome / R.M. Yates and D.G. Russell -- Maturation changes in purified phagosomes / R. Dieckmann ... [et al.] -- Large-scale purification of latex bead phagosomes from mouse macrophage cell lines and subsequent preparation for high-throughput quantitative proteomics / A. Rupper and J. Cardelli -- Class II MHC Antigen Processing in Phagosomes / L. Ramachandra, W.H. Boom and C.V. Harding -- Analyzing Association of the Endoplasmic Reticulum with the Legionella pneumophila-Containing Vacuoles by Fluorescence Microscopy / A. Ingmundson and C.R. Roy -- Fractionation of the Coxiella burnetii Parasitophorous Vacuole / D. Howe and R.A. Heinzen -- Bacterial Phagosome Acidification Within IFN-gamma-Activated Macrophages: Role of Host p47 Immunity-Related GTPases (IRGs) / S. Tiwari and J.D. Macmicking -- SopE-Mediated Recruitment of Host Rab5 on Phagosomes Inhibits Salmonella Transport to Lysosomes / R. Madan, G. Krishnamurthy and A. Mukhopadhyay -- The Mycobacterium tuberculosis Phagosome / E.A. Roberts and V. Deretic.
- v. 1-, 2014 ScienceDirectv. 2, 2014 ScienceDirectv.3, 2014 ScienceDirectedited by M.A. Hayat.Volume 1. Molecular mechanisms -- Volume 2. Role in general diseases -- Volume 3. Mitophagy.
- 2009 SpringerBeth Levine, Tamotsu Yoshimori, Vojo Deretic, editors.Also available: Print – 2009
- 2015 Wileyedited by William T. Jackson and Michele S. Swanson.Autophagy and immunity / Xu Liu and Daniel J. Klionsky -- Techniques for studying autophagy / Isei Tanida and Masato Koike -- Role of autophagy in DNA virus infections in vivo / Xionan Dong and Beth Levine -- Studying RNA viruses and autophagy in vivo / Mehrdad Alirezaei and J. Lindsay Whitton -- Autophagy and picornavirus infection / Tom Wileman, Zhigang Zhou, Matthew Whelband, Eleanor Cottam, Stephen Berryman, Terry Jackson, and Rebecca Roberts -- Flaviviruses and autophagy / Tristan X. Jordan and Glenn Randall -- Autophagy : a home remodeler for Hepatitis C virus / Marine L.B. Hillaire, Elodie Decembre, and Marlene Dreux -- Modulating autophagy to cure Human Immunodeficiency Virus type-1 / Stephen A. Spector and Grant R. Campbell -- Autophagy in the infected cell : insights from pathogenic bacteria / Andrea Sirianni and Serge Mostowy -- Rab proteins in autophagy: streptococcus model / Ichiro Nakagawa -- Helicobacter pylori infection control by autophagy / Laura K. Greenfield, Frances Dang, and Nicola L. Jones -- Interactions between salmonella and the autophagy system / Teresa L.M. Thurston and David W. Holden -- Host factors that recruit autophagy as defense against toxoplasma gondii / Carlos S. Subauste -- Mycobacterium tuberculosis and the autophagic pathway / Gabriela María Recalde and María Isabel Colombo -- Autophagy enhances the efficacy of BCG vaccine / Arshad Khan, Christopher R. Singh, Emily Soudani, Pearl Bakhru, Sankaralingam Saikolappan, Jeffrey D. Cirillo, N. Tony Eissa, Subramanian Dhandayuthapani, and Chinnaswamy Jagannath -- Autophagy's contribution to innate and adaptive immunity : an overview / Christina Bell, Michel Desjardins, Pierre Thibault, and Kerstin Radtke -- Autophagy in immune responses to viruses / Christophe Viret and Mathias Faure -- Processing and MHC presentation of antigens after autophagy-assisted endocytosis, exocytosis and cytoplasm degradation / Christian Münz.
- 2016 SpringerMaria Chiara Maiuri, Daniela De Stefano, editors.Autophagy in direct pathogen elimination (Xenophagy) -- Autophagy and pattern recognition receptors -- Autophagy and inflammasomes -- Autophagy and Antigen presentation -- Autophagy and regulation of T and B cell function -- Autophagy in chronic inflammation -- The complex crosstalk between autophagy and ROS -- Lipophagy -- Autophagy, phagocytosis and entosis: who eats whom?- Which is the cell fate of inflammatory cells ? Autophagic cell death, pyroptosis, netosis, apoptosis, necrosis -- Host defence (virus/bacteria) -- Neurological diseases -- Pulmonary diseases (emphysema, COPD, etc.) -- Inflammatory bowel disease -- Target autophagy as a novel therapeutic strategy in autoimmune diseases -- Liver and pancreatic diseases -- Obesity -- Aging -- Overview on clinical trials.Also available: Print – 2016
- 2014 ScienceDirectedited by Karel Schat, Bernd Kaspers, Pete Kaiser.Provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, this book encompasses all aspects of innate and adaptive immunity in chickens.
- 2016 SpringerTomohiro Kurosaki, Jürgen Wienands, editors.Assembly and function of the precursor B-cell receptor -- Receptor Dissociation and B cell activation -- Molecular mechanisms of B cell antigen gathering and endocytosis -- BTK signaling in B cell differentiation and autoimmunity -- The memory function of the B cell antigen receptor -- PI3K signaling in normal B cells and chronic lymphocytic leukemia (CLL) -- Role of Calcium Signaling in B Cell Activation and Biolog -- Roles of the NF-kappaB pathway in B-lymphocyte biology -- MAP kinase cascades in antigen receptor signaling and physiology.
- 2016 Springer Protocolsedited by Jan Michiels and Maarten Fauvart.Historical perspective on bacterial persistence / Natalie Verstraeten ... [et al.] -- Persisters : methods for isolation and identifying contributing factors-a review / Sarah E. Rowe ... [et al.] -- General method for measuring persister levels in Escherichia coli cultures / Niilo Kaldalu ... [et al.] -- Optimized method for measuring persistence in Escherichia coli with improved reproducibility / F. Goormaghtigh and L. Van Melderen -- Microplate-based system as in vitro model of biofilm growth and quantification / Ilse Vandecandelaere, Heleen Van Acker, and Tom Coenye -- Protocol for determination of the persister subpopulation in Candida Albicans biofilms / Katrijn De Brucker ... [et al.] -- Quantitative measurements of type I and type II persisters using ScanLag / Irit Levin-Reisman and Nathalie Q. Balaban -- Analyzing persister physiology with fluorescence-activated cell sorting / Mehmet A. Orman ... [et al.] -- Single-cell detection and collection of persister bacteria in a directly accessible femtoliter droplet array / Ryota Iino ... [et al.] -- Whole-cell-based high-throughput screening method to identify molecules targeting Pseudomonas Aeruginosa persister cells / Veerle Liebens, Valerie Defraine, and Maarten Fauvart -- Functional analysis of the role of toxin-antitoxin (TA) loci in bacterial persistence / Aaron T. Butt and Richard W. Titball -- Experimental evolution of Escherichia coli persister levels using cyclic antibiotic treatments / Bram Van den Bergh, Joran E. Michiels, and Jan Michiels -- In vitro models for the study of the intracellular activity of antibiotics / Julien M. Buyck ... [et al.] -- Murine model for Escherichia coli urinary tract infection / Thomas J. Hannan and David A. Hunstad -- Analysis of macrophage-induced Salmonella persisters / Robert A. Fisher, Angela M. Cheverton, and Sophie Helaine -- Population dynamics analysis of ciprofloxacin-persistent S. Typhimurium cells in a mouse model for Salmonella diarrhea / Patrick Kaiser, Roland R. Regoes, and Wolf-Dietrich Hardt -- Computational methods to model persistence / Alexandra Vandervelde ... [et al.].
- 2009 ClinicalKeyMark Peakman, Diego Vergani ; illustrated by Robert Britton and Ethan Danielson.Anatomy and cells of the immune system -- Innate immunity I: physical and humoral protection -- Innate immunology II: cellular mechanisms -- Acquired immunity: antigen receptors -- The human leukocyte antigens -- Cellular immune responses I: dendritic cells, macrophages and B lymphocytes -- Cellular immune responses II: T lymphocytes, antigen presentation and natural killer cells -- The immune response to microbes: an overview -- Tolerance and mechanisms of autoimmunity -- Hypersensitivity reactions and clinical allergy -- Transplantation -- Rheumatic diseases -- Endocrine autoimmune disease -- Liver diseases -- Gastrointestinal diseases -- Immune-mediated nephritis and vasculitis -- Immune-mediated skin disease -- Immune-mediated diseases of the nervous system and eye -- Immunodificiency -- Human immunodeficiency virus and AIDS -- Immunological manifestations of haematological disease -- Immune-based therapies -- Immunisation.
- 2016 ClinicalKeyAbul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; Illustrations by David L. Baker, Alexandra Baker.Introduction to the immune system : nomenclature, general properties, and components -- Innate immunity : the early defense against infections -- Antigen capture and presentation to lymphocytes : what lymphocytes see -- Antigen recognition in the adaptive immune system : structure of lymphocyte antigen receptors and development of immune repertoires -- T cell-mediated immunity : activation of t lymphocytes by cell-associated antigens -- Effector mechanisms of t cell-mediated immunity : functions of t cells in host defense -- Humoral immune responses : activation of b lymphocytes and production of antibodies -- Effector mechanisms of humoral immunity : elimination of extracellular microbes and toxins -- Immunological tolerance and autoimmunity : self-nonself discrimination in the immune system and its failure -- Immune responses against tumors and transplants : immunity to noninfectious transformed and foreign cells -- Hypersensitivity : disorders caused by immune responses -- Congenital and acquired immunodeficiencies : diseases caused by defective immunity.
- 2014 Springer Protocolsedited by Bernhard F. Gibbs, Franco H. Falcone.Paradigm shifts in mast cell and basophil biology and function : an emerging view of immune regulation in health and disease / Ana Olivera and Juan Rivera -- Purification of basophils from peripheral human blood / Franco H. Falcone and Bernhard F. Gibbs -- Mast cell purification protocols / Jasmine Farrington , Elizabeth P. Seward , and Peter T. Peachell -- Generation of a human allergic mast cell phenotype from CD133+ stem cells / Hans Jürgen Hoffmann -- Generation of mast cells from murine stem cell progenitors / Emily J. Swindle -- Integration of the human dermal mast cell into the organotypic co-culture skin model / Jonghui Kim [and four others] -- The absolute basophil count / Elena Borzova and Clemens A. Dahinden -- Mast cell and basophil cell lines : a compendium / Egle Passante -- Detection of mast cells and basophils by immunohistochemistry / Andrew F. Walls and Cornelia Amalinei -- Measuring histamine and cytokine release from basophils and mast cells / Bettina M. Jensen, Sidsel Falkencrone, and Per S. Skov -- Flow cytometric allergy diagnosis : basophil activation techniques / Chris H. Bridts [and five others] -- Microscopy assays for evaluation of mast cell migration and chemotaxis / Monika Bambousková [and three others] -- Use of humanized rat basophil leukemia (RBL) reporter systems for detection of allergen-specific IgE sensitization in human serum / Daniel Wan [and four others] -- Gene silencing approaches in mast cells and primary human basophils / Vadim V. Sumbayev and Bernhard F. Gibbs -- Basophil stimulation and signaling pathways / Edward F. Knol and Bernhard F. Gibbs -- Identification and immunophenotypic characterization of normal and pathological mast cells / José Mário Morgado [and three others] -- Identification of murine basophils by flow cytometry and histology / Christian Schwartz and David Voehringer -- Mast cell-mediated reactions in vivo / Vladimir Andrey Giménez-Rivera , Martin Metz, and Frank Siebenhaar.
- 2015 SpringerYoshiaki Ishigatsubo, editor.This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
- 2014 SpringerLorenzo Emmi, editor.1. The Numbers of Behçet: A Rare Disease? / Agata Polizzi and Domenica Taruscio -- 2. From Hippocrates to Hulusi Behçet: What History / Donatella Lippi -- 3. Epidemiology of Behçet Syndrome / Olga Addimanda, Giulia Pazzola, Nicolò Pipitone and Carlo Salvarani -- 4. Behçet's Syndrome According to Classical and Population Genetics / Akira Meguro, Nobuhisa Mizuki, Ahmet Gül, Nobuyoshi Kitaichi and Shigeaki Ohno -- 5. Infections, Autoimmunity, and Behçet's Syndrome: What Liaison? / Mario Milco D'Elios, Marisa Benagiano, Amedeo Amedei and Giacomo Emmi -- 6. Pathogenesis of Behçet Syndrome / Giacomo Emmi, Danilo Squatrito, Elena Silvestri, Alessia Grassi and Lorenzo Emmi -- 7. Mucocutaneous Involvement in Behçet's Syndrome / Umit Tursen -- 8. Neurological and Neuropsychological Manifestation in Behçet's Syndrome / Shunsei Hirohata -- 9. Ocular Involvement and Behçet Disease / Lorenzo Vannozzi, Ugo Menchini and Massimo Accorinti -- 10. Articular and Muscular Manifestations in Behçet's Disease / Anne-Claire Desbois, Betrand Wechsler and David Saadoun -- 11. Cardiovascular Issues: Aneurysms and Pseudoaneurysms, Thrombosis, Atherosclerosis, and Cardiac Involvement / Elena Silvestri, Caterina Cenci, Chiara Della Bella, Anna Maria Cameli and Domenico Prisco -- 12. Intestinal Behçet Disease / Cristina Cenci and Monica Milla -- 13. Audio Vestibular Involvement in Behçet's Disease / Paolo Vannucchi and Rudi Pecci -- 14. Behçet's Syndrome and Gynecological Manifestation in Reproductive Age and Pregnancy / Maria Elisabetta Coccia and Tommaso Capezzuoli -- 15. Pediatric Onset of Behçet Syndrome / Ezgi Deniz Batu, Rolando Cimaz and Seza Özen -- 16. Behçet's Disease. Differential Diagnosis / Maria Grazia Sabbadini and Stefano Franchini -- 17. Classification and Diagnosis Criteria for Behçet's Disease / Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams and Abdolhadi Nadji -- 18. Prognosis and Disease Activity / Rosaria Talarico, Anna d'Ascanio, Rossella Neri, Chiara Baldini, Marta Mosca and Stefano Bombardieri -- 19. Old and New Treatment for Behçet's Disease / Fabrizio Cantini and Gerardo Di Scala -- 20. Surgical Treatment of Angio-Behçet / Stefano Camparini and Genadi Genadiev.
- 2013 SpringerUlrich Dobrindt, Jörg H. Hacker, Catharina Svanborg, editors.E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity / Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt -- What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? / Ralf Rosenstein, Friedrich Götz -- Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung / Michael Hogardt, Jürgen Heesemann -- Lactobacillus: Host-Microbe Relationships / John O'Callaghan, Paul W. O'Toole -- Bacterial Moonlighting Proteins and Bacterial Virulence / Brian Henderson, Andrew Martin -- Symbionts and Pathogens: What is the Difference? / Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya -- Ecology and Physiology of the Intestinal Tract / Michael Blaut -- The Gut Microflora and Its Variety of Roles in Health and Disease / Julia-Stefanie Frick, Ingo B. Autenrieth -- Host-Recognition of Pathogens and Commensals in the Mammalian Intestine / Oriana Rossi, Peter van Baarlen, Jerry M. Wells -- Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age / Jing Cheng, Airi M. Palva, Willem M. de Vos.
- 2010 SpringerDarren R. Flower, Matthew N. Davies, Shoba Ranganathan, editors.
- 2014 ScienceDirectedited by Ken Ishii and Choon Kit TangBiological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
- 2016 SpringerIvan D. Montoya, editor.Introduction -- PART I: Vaccines: Introduction -- Nicotine -- Cocaine -- Heroin -- Metamphetamine -- PART II: Monoclonal antibodies: Introduction -- Cocaine -- Metamphetamine -- PCP -- PART III: Enzymes: Introduction -- Butyrylcholinesterase -- Cocaine Esterase -- PART IV: New strategies to optimize the development of biologics: Adenovirus based vaccines -- Nanotechnology based vaccines -- Protein Nanoparticles -- DNA Scaffolded Vaccines -- Single Hapten Conjugate Therapeutic Vaccine -- Vaccine Adjuvants -- Laser Adjuvant -- Peptide Conjugates & Cytokine Adjuvants -- T. brucei: A Platform for Immunization -- Vaccines for SUDs and HIV infection -- New Monoclonal Antibodies -- Protein Engineered for Controlled Duration of Action -- PART V: Ethical aspects of biologics to treat SUDs.
- 2011 SpringerRoland E. Kontermann, editor."The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A deeper understanding of effector cell biology and especially developments in the field of antibody engineering has led to the generation of new classes of bispecific antibodies capable of circumventing many of these obstacles. Furthermore, new applications were established for bispecific antibodies, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies, but also on emerging applications such as dual targeting strategies, i.e., the simultaneous inhibition of two targets (cytokines, receptors, etc.) are provided. This book is intended for a broad readership in the field of antibody engineering, mainly from the pharmaceutical and biotechnology sector, but also including academic researchers working in this field."--Publisher's website.
- 2014 Springer Protocolsedited by Meral Beksac.Reporter Gene Technologies for Imaging Cell Fates in Hematopoiesis / Sophie Kusy and Christopher H. Contag -- Flow Cytometry for Hematopoietic Cells / Daniela S. Krause, Michelle E. DeLelys, and Frederic I. Preffer -- Isolation and Characterization of Mesenchymal Stem Cells / Sedat Odabas, A. Eser Elçin, and Y. Murat Elçin -- Methods for Functional Analysis of Stem Cells / Michelle Escobedo-Cousin, J. Alejandro Madrigal, and Aurore Saudemont -- An Overview of HLA Typing for Heamatopoietic Stem Cell Transplantation / Katy Latham, Ann-Margaret Little, and J. Alejandro Madrigal -- HLA Typing with Sequence-Specific Oligonucleotide Primed PCR (PCR-SSO) and Use of the Luminex Technology / Klara Dalva and Meral Beksaç -- Sequence Based Typing of HLA: An Improved Group Specific Full Length Gene Sequencing Approach / Christina E.M. Voorter, Fausto Palusci, and Marcel G.J. Tilanus -- Molecular Typing Methods for Minor Histocompatibility Antigens / Eric Spierings -- Natural Killer Cells and Killer-cell Immunoglobulin-like Receptor Polymorphisms: Their Role in Hematopoietic Stem Cell Transplantation / Jennifer Schellekens, Katia Gagne, and Steven G.E. Marsh -- Methods of Detection of Immune Reconstitution and T Regulatory Cells by Flow Cytometry / Richard Charles Duggleby and J. Alejandro Madrigal -- Molecular Methods Used for Detection of Minimal Residual Disease Following Hematopoietic Stem Cell Transplantation in Myeloid Disorders / Ahmet H. Elmaagacli -- Molecular Methods for Detection of Minimal Residual Disease Following Transplantation in Lymphoid and Plasma Cell Disorders / Paolo Corradini and Cristiana Carniti -- Molecular Methods for Detection of Invasive Fungal Infections and Mycobacteria and Their Clinical Significance in Hematopoietic Stem Cell Transplantation / Pinar Yurdakul and Sule Colakoglu -- Post-transplant Monitoring of Chimerism by Lineage-specific Analysis / Sandra Preuner and Thomas Lion -- Urinary Proteomics Employing Capillary Electrophoresis Coupled to Mass Spectrometry in The Monitoring Of Patients After Stem Cell Transplantation / Eva M. Weissinger, William Mullen, and Amaya Albalat.
- 2007 Springer Protocolsedited by Meral Beksac.
- 2013 SpringerAndreas Rummel, Thomas Binz, editors.The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
- 2012 SpringerArmen A. Galoyan.The Cytokine System -- The Discovery of the Brain Immunomodulators -- Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines Produced by NSO and NPV of Hypothalamus -- Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action -- Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin -- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection with Proline-Rich Polypeptides Galarmin and Its Structural Analogues in an Experimental Murine Model -- Treatment of Clostridium Perfringens-induced Gas Gangrene by New Cytokines of Brain -- Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection -- Brain-Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone Marrow Progenitor cells -- Antioxidant-Antiradical and Electron Donating Function of Galarmin and Gx-NH2 -- Discussion -- Summary.
- 2011 Springeredited by M. Eric Gershwin, Timothy E. Albertson.
- 2012Moria Cairns Chambers.How does your immune system prepare for all of the potential pathogens it might face over the course of a lifetime? Trade-offs occur when you invest in responses that are beneficial when fighting one pathogen but are actively detrimental for fighting another. Due to the diversity of pathogens, immunity is potentially rife with this type of antagonism; to appreciate the full scope of potential trade-offs we must think about all of the possible immune responses a host can bring to bear on a pathogen. I propose that an "immune response" is any response to infection that influences the outcome of that infection. This includes processes that affect either resistance, the ability to clear pathogen, or tolerance, the ability to cope with pathology induced by infection. This broad definition of immunology will bring research of classically "non-immune" physiologies - metabolism, circadian rhythm and mating -- into the immune arena. Throughout this thesis I will explore, using Drosophila melanogaster as a model, a number of different trade-offs in immunity from the antagonism inherent in a resistance response to the benefits and consequences of energy expenditure during infection. First, I demonstrate that there is an inherent trade-off due to investment in phagocytosis when flies encounter two different infections: Listeria monocytogenes and Streptococcus pneumoniae. L. monocytogenes is a facultative intracellular pathogen that harnesses the additional phagocytosis, increasing entry into a desirable niche; S. pneumoniae is an extracellular pathogen that is better cleared by increased phagocytosis. I discovered the trade-off by comparing and contrasting the phenotypes caused by mutants in two Drosophila immunity genes: ets21c, a putative transcription factor, and wntD, a negative regulator of immunity. Further exploration of the immune phenotypes of the ets21c mutant revealed that these mutants have a range of phenotypes during infection, suggesting a complex picture. Ets21c affects both tolerance and resistance to infection, and the class of phenotype observed in ets21c mutants cannot be predicted solely by the intracellular versus extracellular nature of the infecting pathogen. Ets21c mutants also have a strikingly altered basal metabolic state, resembling sick wild-type flies, and have a muted change in transcript levels in response to infection. This thesis also deepens our understanding of developmental-immune pleitropy in the wntD pathway. Pleitropy itself causes trade-offs; for while pleitropy promotes efficiency in the genome, it also restricts the ability to evolve. WntD, a negative regulator of the toll pathway, impacts both immunity and dorsal-ventral development. Recently, work with the developmental phenotypes led to the discovery of components in the wntD signaling pathway. I show that these developmental mediators are also involved in immunity and impact survival during L. monocytogenes infection. L. monocytogenes infection causes infection induced anorexia in Drosophila and this thesis shows that infection with L. monocytogenes affects a number of metabolic pathways at both the transcript and metabolite level. This metabolic and transcriptome data generated a number of more specific and mechanistic hypotheses concerning additional potential trade-offs. First, energy stores, metabolic intermediates and transcripts for beta-oxidation and glycolysis decrease during infection. This reduction of available energy can both negatively impact the host when it runs out of energy for essential processes and positively impact the host by restricting the nutrients available to the pathogen. By infecting mutants with either initially low energy stores or an inability to access stores, we show that access to energy stores is important to the host during infection, although the flip-side of this trade-off remains untested. A second potential trade-off seen through our metabolomics are changes in the level of an anti-oxidant, uric acid. The flies enzymatically reduce levels of uric acid during L. monocytogenes infection. A reduction in an anti-oxidant should cause the reactive oxygen species to have additional potency. This would be helpful in combating the bacterial load, but potentially detrimental due to an increase of damage to the host itself. However, mutants in uricase, which fail to lower uric acid levels during infection, do not have such easily explainable phenotypes potentially due to compensation through other anti-oxidants. While not conclusive, these data suggest that the flies regulate their anti-oxidant levels during infection and that this complexly affects immunity. To address the dilemma of how to build a robust immune response, I contend that one must consider many different variables: diversity of pathogens, genetic efficiency, and the energetic cost. Years of evolution have honed the immune responses with many potential solutions. I found that Drosophila immune systems are likely constrained by a variety of tradeoffs -- antagonistic abilities of resistance responses, metabolic links with immunity, and developmental-immune pleitropy. We still need to better understand how these tradeoffs are regulated and their downstream implications. Understanding these antagonistic relationships will help us manipulate them to develop more effective treatment, as we can tailor medicine to the individual pathogen and the individual person's physiology.
- 2010 SpringerManuel L. Penichet, Erika Jensen-Jarolim, editors.
- 2014 Wileyedited by Dr. Yusuke Hiraku, Dr. Shosuke Kawanishi, Dr. Hiroshi Ohshima.Infection, inflammation, and cancer: overview / Hiroshi Ohshima, Noriyuki Miyoshi, and Susumu Tomono -- Stem cell theory and inflammation-related cancer / Toshihiko Tanno and William Matsui -- Epithelial-mesenchymal transition: a link between cancer and inflammation / Jonas Fuxe and Mikael C.I. Karlsson -- Role of nitrative DNA damage in inflammation-related carcinogenesis / Yusuke Hiraku and Shosuke Kawanishi -- Lipid peroxidation-derived DNA adducts and the role in inflammation-related carcinogenesis / Helmut Bartsch and Urmila Jagadeesan Nair -- Level of inflammation-related DNA adducts in human tissues / Tomonari Matsuda, Pei-Hsin Chou, and Haruhiko Sugimura -- Toll-like receptors: role in inflammation and cancer / Sarang Tartey and Osamu Takeuchi -- Inflammasomes and inflammation / Kaiwen W. Chen, Ayanthi A. Richards, Alina Zamoshnikova, and Kate Schroder -- Activation-induced cytidine deaminase: an intrinsic genome modulator in inflammation-associated cancer development / Hiroyuki Marusawa and Tsutomu Chiba -- MicroRNA and inflammation-related cancer / Zhaojian Gong, Zhaoyang Zeng, Pranab Behari Mazumder, Jian Ma, Ming Zhou, Xiayu Li, Xiaoling Li, Wei Xiong, Yong Li, and Guiyuan Li -- Inflammation as a niche for tumor progression / Futoshi Okada -- Human papillomavirus and cervical cancer / Kurt J. Sales -- Hepatitis viruses and hepatocellular carcinoma / Wai-Kay Seto, Ching-Lung Lai, and Man-Fung Yuen -- Epstein-Barr virus and nasopharyngeal carcinoma / Xiaoying Zhou, Xue Xiao, Fu Chen, Tingting Huang, and Zhe Zhang -- Barrett's esophagus and esophageal cancer / Albert Roessner and Angela Poehlmann -- Asbestos-induced chronic inflammation and cancer / Andrea Napolitano, Sandro Jube, Giovanni Gaudino, Harvey I. Pass, Michele Carbone, and Haining Yang -- Nanomaterials / Yiqun Mo, Rong Wan, David J. Tollerud, and Qunwei Zhang -- Inflammatory pathways of radiation-induced tissue injury / Danae A. Laskaratouu, Ifigeneia V. Mavragani, and Alexandros G. Georgakilas -- Photocarcinogenesis and inflammation / Chikako Nishigori -- Chemoprevention of colorectal cancer by anti-inflammatory agents / Michihiro Mutoh, Mami Takahasi, and Keiji Wakabayashi -- Nutraceuticals and colon cancer prevention / Deepak Poudyal and Lorne J. Hofseth -- Cancer chemoprevention by targeting cox-2 using dietary phytochemicals / Kyung-Soo Chun and Young-Joon Surh -- Regulation of inflammation-associated intestinal diseases with phytochemicals / Akira Murakami.
- 2015 SpringerNima Rezaei, editor.Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.
- 2015 SpringerNima Rezaei, editor.This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗l The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
- 2015 SpringerNima Rezaei, editor.Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.
- 2011 SpringerGlenn Dranoff, Editor.Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].Also available: Print – 2011
- 2014 SpringerCedrik Michael Britten, Sebastian Kreiter, Mustafa Diken, Hans-Georg Rammensee, editors.This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
- 2014 Springer Protocolsedited by Michael J.P. Lawman and Patricia D. Lawman.Single Step Antigen Loading and Maturation of Dendritic Cells Through mRNA Electroporation of a Tumor-Associated Antigen and a TriMix of Costimulatory Molecules -- Generation of Multiple Peptide Cocktail-Pulsed Dendritic Cells as a Cancer Vaccine -- Pulsing Dendritic Cells with Whole Tumor Cell Lysates -- Antigen Trapping by Dendritic Cells for Anti-Tumor Therapy -- Ex Vivo Loading of Autologous Dendritic Cells with Tumor Antigens -- Tumor Antigen/Cytokine-Pulsed Dendritic Cells in Therapy Against Lymphoma -- Dendritic Cells Primed with Protein-Protein Fusion Adjuvant -- Antigen-Specific mRNA Transfection of Autologous Dendritic Cells -- Electroporation of Dendritic Cells with Autologous Total RNA from Tumor Material -- Dendritic Cells Transfected with Adenoviral Vectors as Vaccines -- Genetic Modification of Dendritic Cells with RNAi -- Fast Monocyte-Derived Dendritic Cells-Based Immunotherapy -- Intratumoral Injection of BCG-CWS Pretreated Dendritic Cells Following Tumor Cryoablation -- Exploiting the CD1d-iNKT Cell Axis for Potentiation of DC-Based Cancer Vaccines -- Modification of T Lymphocytes to Express Tumor Antigens -- Genetic Modification of Mouse Effector and Helper T Lymphocytes Expressing a Chimeric Antigen Receptor -- Genetic Modification of Cytotoxic T Lymphocytes to Express Cytokine Receptors -- Monitoring the Frequency and Function of Regulatory T Cells and Summary of the Approaches Currently Used to Inhibit Regulatory T Cells in Cancer Patients -- Cytokine Activation of Natural Killer Cells -- Loading of Acute Myeloid Leukemia Cells with Poly(I:C) by Electroporation -- Autologous Tumor Cells Engineered to Express Bacterial Antigens -- Tumor Cell Transformation Using Antisense Oligonucleotide -- The Direct Display of Costimulatory Proteins on Tumor Cells as a Means of Vaccination for Cancer Immunotherapy -- Cloning Variable Region Genes of Clonal Lymphoma Immunoglobulin for Generating Patient-Specific Idiotype DNA Vaccine -- Heat Shock Proteins Purified from Autologous Tumors Using Antibody-Based Affinity Chromatography -- Invariant Chain-Peptide Fusion Vaccine Using HER-2/neu -- TLR-9 Agonist Immunostimulatory Sequence Adjuvants Linked to Cancer Antigens -- Production of Multiple CTL Epitopes from Multiple Tumor-Associated Antigens -- Preparation of Polypeptides Comprising Multiple TAA Peptides -- Idiotype Vaccine Production Using Hybridoma Technology -- Preparation of Cancer-Related Peptide Cocktails that Target Heterogeneously-Expressed Antigens -- Making an Avipoxvirus Encoding a Tumor-Associated Antigen and a Costimulatory Molecule -- Bacterial Vectors for the Delivery of Tumor Antigens -- Preparation of Peptide Microspheres Using Tumor Antigen-Derived Peptides -- Production of Antigen-Loaded Biodegradable Nanoparticles and Uptake by Dendritic Cells -- Development of Plasmid-Lipid Complexes for Direct Intratumoral Injection -- The Use of Dendritic Cells for Peptide-Based Vaccination in Cancer Immunotherapy -- Advances in Host and Vector Development for the Production of Plasmid DNA Vaccines -- Challenges Facing the Development of Cancer Vaccines -- Future of Cancer Vaccines.
- 2015 Springer Protocolsedited by Bernd Lepenies.Carbohydrate-based vaccines : an overview / Julia Hütter and Bernd Lepenies -- Glycans as vaccine antigens and adjuvants : immunological considerations / Stephanie Zimmermann and Bernd Lepenies -- Glycan array platform as a tool to identify carbohydrate antigens / Li Xia and Jeffrey C. Gildersleeve -- Antibody-carbohydrate recognition from docked ensembles using the AutoMap procedure / Tamir Dingjan, Mark Agostino, Paul A. Ramsland, and Elizabeth Yuriev -- Generation of monoclonal antibodies against defined oligosaccharide antigens / Felix Broecker, Chakkumkal Anish, and Peter H. Seeberger -- Murine whole-blood opsonophagocytosis assay to evaluate protection by antibodies raised against encapsulated extracellular bacteria / Guillaume Goyette-Desjardins, René Roy, and Mariela Segura -- Determination of N-linked glycosylation in viral glycoproteins by negative ion mass spectrometry and ion mobility / David Bitto, David J. Harvey, Steinar Halldorsson, Katie J. Doores, Laura K. Pritchard, Juha T. Huiskonen, Thomas A. Bowden, and Max Crispin -- N-glycosylation fingerprinting of viral glycoproteins by xCGE-LIF / René Hennig, Erdmann Rapp, Robert Kottler, Samanta Cajic, Matthias Borowiak, and Udo Reichl -- Temporary conversion of protein amino groups to azides : a synthetic strategy for glycoconjugate vaccines / Tomasz Lipinski and David R. Bundle -- Gold nanoparticles as carriers for synthetic glycoconjugate vaccines / Fabrizio Chiodo and Marco Marradi -- Identification and characterization of carbohydrate-based adjuvants / Timo Johannssen and Bernd Lepenies -- Characterization of carbohydrate vaccines by NMR spectroscopy / Francesco Berti and Neil Ravenscroft -- Characterization of capsular polysaccharides and their glycoconjugates by hydrodynamic methods / Stephen E. Harding, Ali Saber Abdelhameed, Richard B. Gillis, Gordon A. Morris, and Gary G. Adams -- Glycoconjugate vaccines : the regulatory framework / Christopher Jones.
- 2008Raif Geha, Fred Rosen.
- c2012Raif S. Geha & Luigi Notarangelo
- 2012Raif Geha, Luigi Notarangelo.
- CD14-expressing bladder cancer cells establish tumor-promoting inflammation and drive tumor cell proliferation2013Ming Tatt Cheah.Keratin 14 (KRT14) expression marks the most primitive differentiation state in bladder cancer (BC) cells. However, the mechanisms by which KRT14-expressing cells promote tumorigenicity remain undefined. We found that KRT14-expressing cells express higher levels of CD14 and inflammatory factors such as IL6 and IL8. Using a syngeneic mouse BC model, we isolated CD14 high BC cells and show that this population is more tumorigenic compared to CD14 low cells and forms tumors that are more highly vascularized with higher myeloid cell infiltration. Inflammatory factors produced by CD14 high BC cells directly drive the recruitment and polarization of monocytes and macrophages to acquire immune-suppressive characteristics. In contrast, CD14 low BC cells have higher relative proliferation, which is markedly increased when stimulated by factors produced by CD14 high cells. Collectively, we demonstrate that CD14 high BC cells orchestrate tumor-promoting inflammation and drive tumor cell proliferation to promote tumor growth.
- 2006 Springeredited by Lieping Chen.
- 2011Michael Nathaniel Alonso.Monocytes rapidly infiltrate inflamed tissues and differentiate into inflammatory dendritic cells (DCs) that mediate pathogen clearance. However, the cellular and molecular mechanisms governing inflammatory DC formation and subsequent function remain elusive. Current evidence suggests that conserved molecular patterns present on different classes of microbes that engage pattern recognition receptors on DCs dictate the type of immune response initiated by DCs. Given that pathogens are under evolutionary pressure to avoid elimination, we reasoned that memory T cells were better positioned to inform the immune response. The studies presented in this dissertation indicate that memory T cells dictate the nature of the immune response through the induction of functionally specialized inflammatory DCs. Our studies indicate that T-helper (TH) cells interact with monocytes in inflamed tissues and instruct monocytes to differentiate into inflammatory DCs in vivo. This process is antigen-driven and requires cell contact, GM-CSF and TNF[alpha]. Interestingly, distinct TH cell subsets direct the formation of specialized DC subsets. In psoriasis lesions, TH1 and TH17 cells interact with monocytes and instruct these cells to differentiate into TH1- and TH17-promoting DCs, respectively. Correspondingly, in acute atopic dermatitis, TH2 cells interact with monocytes and elicit the formation of TH2-promoting DCs. Again, DC formation required GM-CSF and cell contact, whereas TH subset specific cytokines dictate DC function and the expression of DC subset specific surface molecules. Moreover, the phenotypes of T cell induced DC subsets are maintained following subsequent stimulation with a panel of toll-like receptor (TLR) agonists, suggesting that TH-derived signals outweigh downstream TLR signals in their influence on DC function. Our preliminary studies indicate that regulatory T cells promote the formation of tolerogenic DCs that are typically associated with tumor progression and poor patient prognosis. The data indicate that intra-tumoral Tregs frequently interact with monocytes within tumor tissue and instruct monocytes to differentiate into IL-10-producing tolerogenic DCs. Such Treg-induced DCs (DCTreg) are subsequently able to instruct naïve T cells to differentiate into FoxP3+, IL-10-producing regulatory T cells with potent suppressive activity. The capacity of Tregs to elicit DCTreg formation represents a physiologic mechanism that on one hand amplifies and perpetuates immune tolerance, but also contributes to attenuated anti-tumor immune responses. We also explored mechanisms capable of depleting inflammatory DCs. While previous studies have indicated that inflammatory DC depletion through systemic elimination of their monocyte precursors with clodronate-loaded liposomes ameliorates pathogenesis in psoriasis and other diseases, translation of these strategies into the clinic is difficult due the importance of monocytes in the clearance of infection. We describe three strategies that avoid the monocyte intermediates in order to directly prevent inflammatory DC formation or deplete inflammatory DCs through antibody-loaded toxins. These strategies provide useful tools for the targeted reduction of inflammatory DCs during disease pathogenesis. In summary, memory T cells dictate the nature of the immune response through the induction of functionally specialized inflammatory DCs. The system we utilized for generating DC subsets with differential TH polarizing capacity has facilitated the elucidation of cell surface and soluble factors governing the biology of TH-promoting DC subsets. These and additional molecules expressed by DC subsets should prove useful for detecting and quantifying each subset in situ and may enable the design of novel therapeutic strategies for T[not]H-associated inflammatory diseases.
- 2005 SpringerB. Kyewski and E. Suri-Payer (eds.).Also available: Print – yyyy
- 2015 Springer Protocolsedited by Anthony W. Ryan.Celiac disease : background and historical context / Graham D. Turner, Margaret R. Dunne, and Anthony W. Ryan -- Celiac disease : diagnosis / Greg Byrne and Conleth F. Feighery -- Generating transgenic mouse models for studying celiac disease / Josephine M. Ju, Eric V. Marietta, and Joseph A. Murray -- Study designs for exploring the non-HLA genetics in celiac disease / Åsa Torinsson Naluai -- Twenty-four hour ex vivo culture of celiac duodenal biopsies / Sarah E. J. Cooper, Sharon Wilson, and Conleth F. Feighery -- Isolation and cloning of gluten-specific T cells in celiac disease / Yvonne Kooy-Winkelaar and Frits Koning -- Flow cytometric analysis of human small intestinal lymphoid cells / Margaret R. Dunne -- Adaptation of a cell-based high content screening system for the in-depth analysis of celiac biopsy tissue / Sarah E. J. Cooper ... [et al.] -- HLA genotyping : methods for the identification of the HLA-DQ2,-DQ8 heterodimers implicated in celiac disease (CD) susceptibility / Maria Edvige Fasano, Ennia Dametto, and Sandra D'Alfonso -- Detecting allelic expression imbalance at candidate genes using 5' exonuclease genotyping technology / Jillian M. Gahan ... [et al.] -- Gene expression profiling of celiac biopsies and peripheral blood monocytes using taqman assays / Martina Galatola, Renata Auricchio, and Luigi Greco -- Cloning gene variants and reporter assays / Ben Molloy and Ross McManus -- Epigenetic methodologies for the study of celiac disease / Antoinette S. Perry, Anne-Marie Baird, and Steven G. Gray -- Candidate gene knockdown in celiac disease / Ben Molloy ... [et al.] -- Perl one-liners : bridging the gap between large data sets and analysis tools / Karsten Hokamp -- Bioinformatic analysis of antigenic proteins in celiac disease / Cathal P. O'Brien -- Quality control procedures for high-throughput genetic association studies / Ciara Coleman, Emma M. Quinn, and Ross McManus -- Quality control and analysis of NGS RNA sequencing data / Emma M. Quinn and Ross McManus.
- 2014 ScienceDirectHerbert Wieser, Peter Koehler, Katharina Konitzer.Celiac disease : a complex disorder -- Gluten : the precipitating factor -- Treatment of Celiac disease -- Gluten-free products.
- 2006 SpringerEckart D. Gundelfinger, Constanze I. Seidenbecher, Buckhart Schraven (eds.).
- 2015 ClinicalKeyAbul K. Abbas, Andrew H. Lichtman, Shiv Pillai ; illustrations by David L. Baker, Alexandra Baker.Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelial interaction, and more.
- 2008 SpringerThomas E. Lane ... [et al.], editors.
- Challenge of highly pathogenic microorganisms : mechanisms of virulence and novel medical countermeasures2010 SpringerAvigdor Schafferman, Arie Ordentlich, Baruch Velan, editors.The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics / Arthur M. Friedlander -- Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases / Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld and Izhak Inbar, et al. -- Dynamics of Bacillus anthracis Infection and Control Mechanisms / Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui and Michèle Mock -- Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages / James B. Bliska -- The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence / Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim and Gideon Halperin, et al. -- The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence / Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy and Ayelet Zauberman, et al. -- Dissection of the Functions of the IglC Protein of Francisella tularensis / Jeanette E. Bröms, Moa Lavander and Anders Sjöstedt -- Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions / Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner and Rima Z. Shaikhutdinova, et al. -- The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization / Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen and Ayelet Zauberman, et al. -- Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process / Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre and Elisabeth Carniel -- Poxvirus Entry into Host Cells / Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte and P.S. Satheskumar -- Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host / Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely and Sharon Melamed, et al. -- Inhibitors of Innate Immunity from Vaccinia Virus / Geoffrey L. Smith -- Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts / Svetlana Bardenstein and Menachem Banai -- MMP-9 as a Marker for Vaccinia Virus Related Encephalitis / Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi and Udy Olshevsky, et al. -- Epidemic Cowpox Virus Infections in Germany / Andreas Kurth and Andreas Nitsche -- The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection / Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar and David Gur, et al. -- Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) / Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein and Einat Ben-Arie, et al. -- Subtyping Biothreat Bacterial Pathogens / Paul Keim and Talima Pearson -- A Rapid Method for Bacillus anthracis Genotyping / Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss and Anat Zvi, et al. -- Tularemia - A Disease with an Uncertain Impact on Public Health / Roland Grunow, Daniela Jacob, Andrea Kühn and Herbert Nattermann -- Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections / Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen and Avigdor Shafferman -- Novel Live Vaccine Candidates Against Airborne Francisella tularensis / Wayne Conlan and Anders Sjöstedt -- Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) / Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson and Orit Gat, et al. -- Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates / Anat Zvi, Naomi Ariel and Avigdor Shafferman -- Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacity / Michael H. Lehmann, Melanie Kremer, Yasemin Suezer and Gerd Sutter -- Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection / Sharon Melamed, Nir Paran, Tomer Israely, Noam Erez and Shaul Reuveny, et al. -- A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity / V.A. Feodorova, L.N. Pan'kina, E.P. Savostina, O.S. Kuznetsov and N.P. Konnov, et al. -- Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies / Yinon Levy, Yehuda Flashner, Ayelet Zauberman, Avital Tidhar and Moshe Aftalion, et al. -- Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect / Ohad Mazor, Einat Ben-Arie, Adva Mechaly, Ronit Rosenfeld and Hadar Marcus, et al. -- The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores / Zeev Altboum, Haim Levy, Shay Weiss, Avi Pass and Nili Rothschild, et al. -- Reverse Vaccinology in Bacillus anthracis / Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru and Haim Grosfeld, et al.
- 2010 SpringerMassoud Mahmoudi, editor.pt. 1. Urticaria and angiodema -- pt. 2. Skin manifestation of drug allergy -- pt. 3. Allergic contact dermatitis -- pt. 4. Other allergies affecting skin and mucous membranes -- pt. 5. Immunologic diseases of the skin.
- 2009 SpringerMassoud Mahmoudi, editor.Rhinitis -- Chronic rhinosinusitis -- Allergic diseases of the eye -- Urticaria and angioedema -- Allergic contact dermatitis -- Hypersensitivity pneumonitis -- Atopic dermatitis -- Food allergy -- Drug allergy -- Anaphylaxis -- Eosinophilia and eosinophilic disorder -- Occupational asthma -- Asthma conundrums -- Mastocytosis -- Allergic bronchopulmonary aspergillosis -- HIV/AIDS and complications -- Disorders of immune regulation -- Autoimmune diseases -- Immune-mediated rheumatic diseases -- Immunodeficiency.
- 2013 SpringerMassoud Mahmoudi, editor.
- Characterization of an RNaseIII protein and its potential roles in the RNA interference pathway of the protozoan parasite, Entamoeba histolytica2012Justine Michelle Pompey.Entamoeba histolytica, a human intestinal parasite and a leading cause of death worldwide, contains a complex repertoire of endogenous small RNAs. Core elements of the RNAi machinery have been identified in the E. histolytica genome including three Argonaute proteins (EhAgo2-1, EhAgo2-2, and EhAgo2-3) and two genes with RNA-directed RNA polymerase (RdRP) domains. However, to date no canonical Dicer enzyme, an RNaseIII endonuclease responsible for cleaving double-stranded RNA (dsRNA) to 20-30nt small RNAs and a critical player in the RNAi pathway, has been identified in the E. histolytica genome. We conducted bioinformatics searches of the genome which revealed only one gene with an RNaseIII domain, EhRNaseIII. Interestingly, this candidate lacks the canonical Dicer structure - it is substantially smaller than other Dicers, contains only a single RNaseIII domain, and lacks PAZ or double-stranded RNA binding domain (dsRBD). Most eukaryotic Dicer proteins identified to date contain two RNaseIII domains, which form a heterodimer required for cleavage of the dsRNA, and contain PAZ or dsRBDs. We determined that EhRNaseIII exists as a homodimer in E. histolytica trophozoites. We sought to probe the contributions of EhRNaseIII, EhAgo2-2, and EhRdRP1 to the RNAi pathway in E. histolytica. Attempts to downregulate these genes using RNA-based methods including antisense mediated silencing and the production of gene-specific secondary small RNAs were unsuccessful. Expression of EhRNaseIII dominant-negative mutants also failed to impair production of small RNAs. In order to determine if EhRNaseIII was capable of generating small RNAs of the size observed in E. histolytica trophozoites, we conducted in vitro cleavage assays of dsRNA. Despite using multiple protein sources (E. histolytica whole cell lysate, immunoprecipitated EhRNaseIII, and recombinant EhRNaseIII protein) and two structurally distinct dsRNA substrates, we were unable to detect small RNA cleavage products. We further investigated whether EhRNaseIII was sufficient to act as a Dicer enzyme by co-expressing it with a dsRNA substrate in Saccharomyces cerevisiae, which lacks an RNAi pathway. However, no small RNAs were detected. We also assessed whether EhAgo2-2, which associates with 5'-polyphosphate small RNAs in E. histolytica, could mediate silencing using 5'-monophosphated small RNAs in S. cerevisiae. No downregulation in reporter transcript or protein was observed. These data indicate that EhRNaseIII is not a minimal Dicer enzyme and suggest that small RNA biogenesis may occur solely through a Dicer-independent small pathway in E. histolytica. These data also suggest that EhAgo2-2 may be specific for 5'-polyphosphate small RNAs. Future studies will continue to investigate the mechanism of small RNA-induced silencing in E. histolytica.
- 2010Patrick Ryan Eimerman.Listeria monocytogenes is a facultative intracellular pathogen that causes severe invasive disease in susceptible populations. Using in vivo bioluminescent imaging, it was recently discovered that this bacterium can colonize the murine gallbladder of otherwise asymptomatic mice. This finding was surprising as L. monocytogenes, after invasion of the intestines, was thought to survive only intracellularly in an infected host and in the gallbladder the bacteria lived extracellularly. It was also surprising that a bacterium could grow and replicate in the pure bile environment of the gallbladder lumen as bile is a potent antimicrobial compound. In this study, we characterized how Listeria monocytogenes is able to reach the gallbladder during infection and examined how this pathogen is able to survive in this environment. Using a mouse adapted L. monocytogenes which expresses a modified InlA capable of binding murine E-cadherin we were able to follow the kinetics of gallbladder colonization after oral infection using in vivo bioluminescent imaging. We then utilized surgical manipulation of the mouse host and repeated the oral infection to determine how L. monocytogenes reaches the gallbladder. Once we had determined the mechanism of gallbladder entry, we then utilized whole genome microarrays to characterize the transcriptome of L. monocytogenes during in vivo growth in the gallbladder and in freshly isolated murine bile. Finally, we attempted to determine what nutrients are utilized by L. monocytogenes during growth in bile and looked at the ability of other bacterial species to grow in this environment. Through these experiments we demonstrated regular asymptomatic gallbladder colonization by L. monocytogenes after oral infection and that L. monocytogenes reaches the gallbladder via the hepatic duct only after first causing systemic infection and escaping the liver. We also demonstrated that the lifestyle in the gallbladder is similar to that in the intestine with the exception of the need for bile resistance genes, and finally that it appears as though simple carbon sources may be utilized during bile growth and that bile may not be as toxic to bacteria as has been thought. Our work suggests that gallbladder colonization may not be exclusive to only L. monocyctogenes and Salmonella Typhi since other bacteria can grow, and in some cases better than L. monocyctogenes, in pure bile.
- 2010Luis Alejandro Zúñiga.Inflammation is characterized by the influx and activation of leukocytes to sites of tissue damage. Upon recruitment, immune cells become activated and can secrete pro-inflammatory cytokines and chemoattractants that can modulate cellular responses and leukocyte trafficking. However, if inflammation occurs inappropriately, it can lead to unwanted tissue damage to the host or can affect metabolic processes (e.g. glucose metabolism or bone metabolism). Evidence indicates inflammation also occurs in adipose tissue during obesity and that adipose tissue leukocytes secrete cytokines that can contribute to systemic, chronic inflammation. The mechanisms that regulate inflammation and mediate its effects on metabolism are not fully understood. To help clarify what factors mediate inflammation, we sought to determine the role that the chemerin receptor, CMKLR1, may play in mediating immune cell trafficking to inflamed tissue. We found CMKLR1 is expressed by murine peritoneal macrophages, which can migrate to chemerin in vitro. CMKLR1 was upregulated by TGF[Beta] and downregulated by pro-inflammatory cytokines and TLR ligands. Furthermore, we found that CMKLR1 exacerbated the progression of experimental murine autoimmune encephalomyelitis (EAE). Chemerin was expressed in inflamed central nervous system (CNS) tissue, and microglial cells and CNS-associated myeloid dendritic cells expressed CMKLR1 in mice with EAE. Additionally, we discovered CCRL2 as a novel receptor for chemerin and determined it is a non-signaling decoy receptor which may bind and present chemerin to CMKLR1. We found that CCRL2 is expressed by mouse mast cells and can enhance tissue swelling and tissue leukocyte infiltration during mast cell-dependent passive cutaneous anaphylaxis. In an attempt to uncover a role for chemerin/CMKLR1 in obesity development or obesity-related inflammation, we discovered an unexpected role for the pro-inflammatory cytokine, IL-17, in adipocyte metabolism. IL-17 was upregulated in obese adipose tissue by T cells. IL-17 KO mice were more susceptible to diet-induced obesity. IL-17 inhibited adipocyte development and insulin stimulated glucose uptake by adipocytes. Furthermore, young IL-17 deficient mice were more insulin sensitive than their WT counterparts. Overall, our data indicate a role for chemerin and chemerin receptors in leukocyte migration and function in inflammatory diseases, and suggest that IL-17 regulates metabolic responses associated with obesity.
- 2010 SpringerØystein Bruserud, editor.Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.Also available: Print – 2010
- 2006 SpringerT.E. Lane, ed.Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system / T.E. Lane, J.L. Hardison, and K.B. Walsh -- Cytokine and chemokine networks : pathways to antiviral defense / T.P. Salazar-Mather and K.L. Hokeness -- Herpes simplex virus and the chemokines that mediate the inflammation / D.J.J. Carr and L. Tomanek -- Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections / K.E. Peterson and B. Chesebro -- HIV-1 coreceptors and their inhibitors / N. Ray and R.W. Doms -- A viral conspiracy : hijacking the chemokine system through virally encoded pirated chemokine receptors / H.F. Vischer, C. Vink, and M.J. Smit.
- Childhood immunization schedule and safety : stakeholder concerns, scientific evidence, and future studies2013Committee on the Assessment of Studies of Health Outcomes Related to the Recommended Childhood Immunization Schedule, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies."The Childhood Immunization Schedule and Safety: Stakeholder Concerns, Scientific Evidence, and Future Studies reviews scientific findings and stakeholders concerns related to the safety of the recommended childhood immunization schedule. This report also identifies potential research approaches, methodologies and study designs that could inform this question, considering strengths, weaknesses as well as ethical and financial feasibility of each approach. This report draws on data from existing surveillance systems, such as the Vaccine Safety Datalink, could be used and offers the best means for ongoing research efforts regarding the safety of the schedule. In recognition of this, future federal research approaches should: collect and assess evidence regarding public confidence in and concerns about the entire childhood immunization schedule, with the goal to improve communication with health care professionals, and between health care professionals and the public regarding safety; standardize definitions of key elements of the schedule, and relevant health outcomes; establish research priorities on the basis of epidemiological evidence, biological plausibility, and feasibility; and continue to fund and support the Vaccine Safety Datalink project to study the safety of the recommended immunization schedule"--Publisher's description.
- 2013 CRCnetBASEedited by Sashwati Roy, Debasis Bagchi, Siba P. Raychaudhuri.Section I. Systems Biology of Inflammation and Regulatory Mechanisms -- Chapter 1. At the Interface between Acute and Chronic Inflammation / Yoram Vodovotz -- Chapter 2. The Cellular Component of Chronic Inflammation / Julie M. Roda, Tim D. Eubank -- Chapter 3. Mast Cells in Chronic Inflammation / Traci A. Wilgus, Brian C. Wulff -- Chapter 4. Hypoxia and Hypoxia-Inducible Factor in Inflammation / Kiichi Hirota -- Chapter 5. Bioactive Phospholipid Mediators of Inflammation / Sainath R. Kotha, Jordan D. Secor, Smitha Malireddy, Gowrishankar Gnanasekaran, Narasimham L. Parinandi -- Chapter 6. Hematopoietic Stem Cells in Atherosclerotic Development and Resolution / Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das -- Chapter 7. Inflammation as a Confounding Factor in Regenerative Medicine / Myron Allukian, Kenneth W. Liechty -- Chapter 8. NOX in the CNS / Annadora J. Bruce-Keller -- Chapter 9. Resolution of Inflammation / Amitava Das, Sashwati Roy -- Chapter 10. H2S in Inflammation / Hyun-Ock Pae, Hun-Taeg Chung -- Section II. Pathologies Associated with Inflammation -- Chapter 11. Is There a Connection between Inflammation and Oxidative Stress? / Chandrakala Aluganti Narasimhulu, Xueting Jiang, Zhaohui Yang, Krithika Selvarajan, Sampath Parthasarathy -- Chapter 12. Chronic Inflammation and Cancer / Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad, Bharat B. Aggarwal -- Chapter 13. Chronic Wounds and Inflammation / Jaideep Banerjee, Chandan K. Sen -- Chapter 14. Multiphasic Roles for TGF-Beta in Scarring / Praveen R. Arany, George X. Huang, Woo Seob Kim -- Chapter 15. Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress / Cameron Rink, Savita Khanna -- Chapter 16. Inflammatory Cascades in Autoimmune Disease / Amita Aggarwal, Arpita Myles -- Chapter 17. Shear Stress and Vascular Inflammation / John Noel, Shampa Chatterjee -- Chapter 18. NGF and Its Receptor System in Inflammatory Diseases / Anupam Mitra, Smriti K. Raychaudhuri, Siba P. Raychaudhuri -- Section III. Nutrition & Therapeutics for Inflammatory Diseases -- Chapter 19. Inflammation, Oxidative Stress, and Antioxidants / Naveen Kaushal, Vivek Narayan, Ujjawal H. Gandhi, Shakira M. Nelson, Anil Kumar Kotha, K. Sandeep Prabhu --Chapter 20. Lipid Biomarkers of Inflammation / Ginger L. Milne -- Chapter 21. Physical Activity and Inflammation / Edite Teixeira de Lemos, Flávio Reis -- Chapter 22. Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes / Philip C. Calder -- Chapter 23. Anti-Inflammatory Phytochemicals, Obesity, and Diabetes / Srujana Rayalam, MaryAnne Della-Fera, Clifton A. Baile -- Chapter 24. Anti-Inflammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome / George Q. Li, Ka H. Wong, Antony Kam, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski, Kelvin Chan -- Chapter 25. Epigenetics and Nutriepigenomics in Chronic Inflammatory Lung Diseases / Saravanan Rajendrasozhan, Isaac K. Sundar, Irfan Rahman -- Chapter 26. Biologics / Ananya Datta Mitra, Debasis Bagchi, Siba P. Raychaudhuri, Smriti K. Raychaudhuri -- Chapter 27. Disease Modifying Anti-Rheumatic Drugs / Nigil Haroon, Vinod Chandran -- Chapter 28. Nonsteroidal Anti-Inflammatory Drugs / Alakendu Ghosh, Pradyot Sinhamahapatra.
- 2011 SpringerVera Price, Paradi Mirmiani (eds.).Introduction -- Clinical Assessment of the Patient -- Dermatopathology -- Medical Management -- Mechanisms and Current Research -- Predominantly Lymphocytic Group -- Predominantly Neutrophilic Group -- Mixed Group -- End Stage Nonspecific Group -- Personal Experiences of Six Patients.
- 2009 SpringerGerald W. Volcheck.
- 2008 Springeredited by Anthony A. Gaspari and Stephen K. Tyring.
- 2009 SpringerAndras Falus, editor.
- 2015 SpringerDédée F. Murrell, editor.This clinical case book serves as a useful guide for dermatologists, internists, family practitioners, pediatricians, and anyone else charged with the care of the skin. The case-based format distinguishes this work from a reference-style textbook, instead allowing readers to relate the presented cases to their own patients. Clinical Cases in Autoimmune Blistering Diseases provides help and insight for clinicians in managing this group of serious and debilitating skin conditions, with each case serving as a springboard for further pursuit and more extensive training. It will enable those new to the field to begin to develop a literacy and competence in autoimmune blistering diseases, while experienced dermatologists will find new ways to sharpen their diagnostic and treatment skills.
- 2012 SpringerAsghar Aghamohammadi, Nima Rezaei, editors.Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs.This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.
- Clinical chemistry, immunology, and laboratory quality control : a comprehensive review for board preparation, certification, and clinical practice2014 ScienceDirectAmitava Dasgupta, Amer Wahed.
- 2013 ClinicalKey[edited by] Robert R. Rich, Thomas A. Fleisher, William T. Shearer, Harry W. Schroeder, Jr., Anthony J. Frew, Cornelia M. Weyand.The human immune response -- Organization of the immune system -- Innate immunity -- Antigen receptor genes, gene products, and co-receptors -- The major histocompatibility complex -- Antigens and antigen presentation -- B-cell development and differentiation -- T-cell development -- Cytokines and cytokine receptors -- Chemokines and chemokine receptors -- Lymphocyte adhesion and trafficking -- T-cell activation and tolerance -- Programmed cell death in lymphocytes and associated disorders -- Immunoglobulin function -- Regulatory T cells -- Helper T-cell subsets and control of the inflammatory response -- Cytotoxic T lymphocytes and natural killer cells -- Host defenses in the skin -- Host defenses at mucosal surfaces -- Complement in host deficiencies and diseases -- Phagocyte deficiencies -- Mast cells, basophils, and mastocytosis -- Eosinophils and eosinophilia -- Host defenses to extracellular bacteria -- Host defenses to intracellular bacteria -- Host defenses to spirochetes -- Host defenses to viruses -- Host defenses to protozoa -- Host defenses to helminths -- Approach to the evaluation of the immunodeficient patient -- Infections in the immunocompromised host -- Maturing of the fetal and neonatal immune system -- Aging and the immune system -- Primary antibody deficiencies -- Primary T-cell immunodeficiencies -- Inherited disorders of IFN-y-, IFN-a/€//\-, and NF-kB-mediated immunity -- HIV infection and acquired immunodeficiency syndrome -- External factors inducing immune deficiency -- Immunological mechanisms of airway diseases and pathways to therapy -- Urticaria, angioedema, and anaphylaxis -- Allergic reactions to stinging and biting insects -- Atopic and contact dermatitis -- Food allergy -- Eosinophil-associated gastrointestinal disorders -- Allergic disorders of the eye -- Drug hypersensitivity -- Occupational asthma -- Mechanisms of autoimmunity -- Interface of autoimmunity and immunodeficiency -- Systemic lupus erthematosus -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Sjögren's syndrome -- Scleroderma-systemic sclerosis -- Inflammatory muscle diseases -- Spondyloarthritis -- Small and medium vessel primary vasculitis -- Large-vessel vasculitides -- Systemic autoinflammatory syndromes -- Antiphospholipid syndrome -- Immunohematologic disorders -- Bullous diseases of the skin and mucous membranes -- Immunology of psoriasis -- Myasthenia gravis -- Multiple sclerosis -- Autoimmune peripheral neuropathies -- Immunologic renal diseases -- Inflammation and atherothrombosis -- Autoimmune thyroid diseases -- Diabetes and related autoimmune diseases -- Immunologic lung diseases -- Sarcoidosis -- Immunologic ocular disease -- Immunologic diseases of the gastrointestinal tract -- Inflammatory hepatobiliary diseases -- Principles of tumor immunology -- Tumor immunotherapy -- Lymphoid leukemias -- Lymphomas -- Monoclonal gammopathies -- Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance -- Stem cell transplantation and immune reconstitution in immunodeficiency -- Hematopoietic stem cell transplantation for malignant diseases -- Thymic reconstitution -- Immunoglobulin therapy: replacement and immunomodulation -- Gene therapy -- Glucocorticoids -- Immunomodulating pharmaceuticals -- Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders -- Vaccines -- Immunotherapy of allergic disease -- Biologic modifiers of inflammatory diseases -- Assessment of proteins of the immune system -- Flow cytometry -- Assessment of functional immune responses -- Assessment of neutrophil function -- Assessment of human allergic diseases -- Molecular methods.
- 2012 Springereditor: Graham R. V. Hughes, Shirish Sangle.pt. 1. The growth of lupus -- 1. Lupus: An introduction -- 2. What is lupus? -- pt. 2. Lupus organ by organ -- 3. Skin --4. Tendons and joints -- 5. Kidney -- 6. The brain -- 7. Heart and blood vessels -- 8. Liver and gastrointestinal tract -- 9. Blood -- pt. 3. Diagnosis and treatment -- 10. Diagnosing lupus -- 11. Treatment -- pt. 4. Lupus-like disorders -- 12. Sjögren's syndrome -- 13. Hughes syndrome (the antiphospholipid syndrome) -- 14. Mixed connective tissue disease (and overlap syndromes) -- 15. Vasculitis -- pt. 5. Lupus-related topics -- 16. Lupus-related topics.
- 2007 SpringerParvin Ganjei-Azar, Mehrdad Nadji.
- 2010 Springeredited by Iqbal Ahmad, Mohammad Owais, Mohammed Shahid, Farrukh Aqil"Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
- 2011Yana Emmy Evangeline Hoy.The importance of the intestinal microbiota to the health of an organism is well recognized. Alterations in the composition of the microbiota are associated with a number of diseases. However, the extent to which the microbiota varies across healthy individuals and time and the causes of this variation are still not fully understood. In order to distinguish between microbial community states of health and disease, the range of healthy microbial communities must be determined. In addition, the effect of perturbations on the microbiota is an area of active research. Recent studies indicate that intestinal infections can have a significant impact on the composition of intestinal microbiota. However, the extent and duration of these changes during different infections have not been fully characterized. My aims were to characterize the range of healthy microbiota in an inbred mouse population over time and to determine the dynamics of alterations in the microbiota during disease. I also wanted to determine if certain characteristics of the microbiota make animals more or less susceptible to infection. In this work, 46 individual healthy mice were sampled over time to assess the range of microbial communities in health. A mouse model of Salmonella enterica serovar Typhimurium infection was used to assess the impact of infection on the microbiota. Mice were sampled prior to infection and over the course of infection. This work finds that the microbiota of healthy mice varies significantly over time and among individuals. However, there are stable differences among individual mice, which may be established at the point of weaning when adult microbial communities develop. In addition, this work finds significant changes in the microbiota during infection that differ with the level of infection. This data also shows that there are some taxa whose abundance prior to infection correlates with outcome of infection. This work provides insights into the dynamics of the microbiota in health and disease and its impact on the health of the host.
- 2006 SpringerPeter F. Zipfel, editor.
- 2014 Springer Protocolsedited by Mihaela Gadjeva.Overview / Mihaela Gadjeva -- Evaluation of complement function by ELISA / Anja Roos and Jörgen Wieslander -- Classical complement pathway component C1q : purification of human C1q, isolation of C1q collagen-like and globular head fragments and production of recombinant C1q-derivatives. Functional characterization / Mihaela Kojouharova -- Classical complement pathway components C1r and C1s : purification from human serum and in recombinant form and functional characterization / Véronique Rossi ... [et al.] -- Expression and purification methods for the production of recombinant human complement component C2 / Angela W. Norton ... [et al.] -- Purification and characterization of human and mouse complement C3 / Marieta M. Ruseva and Meike Heurich -- Purification of human complement protein C5 / Lars Sottrup-Jensen and Gregers Rom Andersen -- Quantification of complement C5b-9 binding to cells by flow cytometry / Oren Moskovich and Zvi Fishelson -- Challenges and opportunities in fractionation of recombinant human mannan-binding lectin / Thomas Vorup-Jensen -- Genotyping of FCN and MBL2 polymorphisms using pyrosequencing / Lea Munthe-Fog, Hans Ole Madsen, and Peter Garred -- Assay for estimation of the functional activity of the mannan-binding lectin pathway of the complement system / Troels R. Kjaer and Steffen Thiel -- Purification, measurement of concentration, and functional complement assay of human ficolins / Misao Matsushita ... [et al.] -- Purification and functional analysis of human properdin / Joseph O'Flynn ... [et al.] -- Purification and functional characterization of C4b- binding protein (C4BP) / Frida C. Mohlin and Anna M. Blom -- Purification and functional characterization of factor I / Sara C. Nilsson and Anna M. Blom -- C1 inhibitor : quantification and purification / Lilian Varga and József Dobó -- Purification, quantification, and functional analysis of complement factor H / Bing-Bin Yu ... [et al.] -- Factor H-related proteins / Mihály Józsi and Seppo Meri -- Functional evaluation of factor H genetic and acquired abnormalities : application for atypical hemolytic uremic syndrome (aHUS) / Lubka T. Roumenina ... [et al.] -- Anti-factor H autoantibodies assay / Marie-Agnès Dragon-Durey ... [et al.] -- Purification of native surfactant protein SP-A from pooled amniotic fluid and bronchoalveolar lavage / Najmunisa Karbani ... [et al.] -- Purification of surfactant protein D (SP-D) from pooled amniotic fluid and bronchoalveolar lavage / Eswari Dodagatta-Marri ... [et al.] -- Functional analysis of C5a effector responses in vitro and in vivo / Christian M. Karsten, Yves Laumonnier, and Jörg Köhl -- Detection of complement receptors 1 and 2 on mouse splenic B cells using flow cytometry / Luke R. Donius and John H. Weis -- Quantification of complement receptor 2 calcium signaling enhancement using flow cytometry / Luke R. Donius and John H. Weis -- Purification of C1q receptors and functional analysis / Berhane Ghebrehiwet and Ellinor I.B. Peerschke -- Detection of cell membrane-bound CD46 using flow cytometry / Martin Kolev and Claudia Kemper -- Detection of CD59 using flow cytometry / Martin Kolev -- Functional analysis of CD59 using complement-dependent cytotoxicity assay / Martin Kolev -- Detection of soluble CR3 (CD11b/CD18) by time-resolved immunofluorometry / Gitte Krogh Nielsen and Thomas Vorup-Jensen - Analysis of the complement activation in mice / Nirmal K. Banda and Kazue Takahashi -- Opsonophagocytic assay / Markryan Dwyer and Mihaela Gadjeva.
- 2013 SpringerJohn D. Lambris, V. Michael Holers, Daniel Ricklin, editors.
- 2013 SpringerYoram Vodovotz, Gary An, editors.An overview of the translational dilemma and the need for translational systems biology of inflammation / Yoram Vodovotz and Gary An -- Part I: Complex systems methods and applications. Translational equation-based modeling / Gilles Clermont ; Agent-based modeling in translational systems biology / Scott Christley and Gary An ; Analysis of heart rate variability / Patrick R. Norris ; Analysis of ventilatory pattern variability / Thomas E. Dick [and seven others] -- Part II. Translational modeling of sepsis and trauma. Disorder of systemic inflammation in sepsis and trauma: a systems perspective / Kent R. Zettel II and Timothy R. Billiar ; Multi-scale equation-based models: insights for inflammation and physiological variability / Jeremy D. Scheff ; Integrating data driven and mechanistic models of the inflammatory response in sepsis and trauma / Nabil Azhar [and five others] ; In silico trials and personalized therapy for sepsis and trauma / Yoram Vodovotz, John Bartels, and Gary An -- Part III: Translational modeling of wound healing. Disorder of localized inflammation in wound healing: a systems perspective / Sashwati Roy, Amitava Das, and Chandan K. Sen ; Equation-based models of wound healing and collective cell migration / Julia Arciero and David Swigon ; Agent-based models of wound healing / Jordan R. Stern [and three others] -- Part IV: Translational modeling of host-pathogen interactions. Modeling host-pathogen interactions in necrotizing enterocolitis / Julia Arciero, Jared Barber, and Moses Kim ; Modeling host-vector-pathogen immuno-inflammatory interactions in malaria / Yoram Vodovotz [and nine others] -- Part V: Future perspectives : translation to implementation. The rationale and implementation of translational systems biology as a new paradigm for the study of inflammation / Gary An and Yoram Vodovotz -- Index.
- 2006 ScienceDirecteditors, Joseph E. Alouf and Michel R. Popoff.
- 2016 SpringerDario Roccatello, Lorenzo Emmi, editors.
- 2013 CRCnetBASEedited by Ernesto Oviedo-Orta, Brenda R. Kwak, William Howard Evans.Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
- 2012 SpringerJulio Aliberti, editor.
- 2012 SpringerRudolf Toman ... [et al.], editors.History and Prospects of Coxiella burnetii Research / Karim E. Hechemy -- Phylogenetic Diversity, Virulence and Comparative Genomics / Erin J. van Schaik and James E. Samuel -- Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche / Katja Mertens and James E. Samuel -- Lipopolysaccharide of Coxiella burnetii / Craig T. Narasaki and Rudolf Toman -- Components of Protective Immunity / Guoquan Zhang, Yan Zhang and James E. Samuel -- Proteome of Coxiella burnetii / Robert Ihnatko, Edward Shaw and Rudolf Toman -- Coxiella Subversion of Intracellular Host Signaling / S. Kauser Hussain and Daniel E. Voth -- The Coxiella burnetii Parasitophorous Vacuole / Eric Ghigo, María I. Colombo and Robert A. Heinzen -- Coxiella burnetii Secretion Systems / Justin A. McDonough, Hayley J. Newton and Craig R. Roy -- Role of Lipids in Coxiella burnetii Infection / Stacey D. Gilk -- Axenic Growth of Coxiella burnetii / Anders Omsland -- Developmental Biology of Coxiella burnetii / Michael F. Minnick and Rahul Raghavan -- Genetic Manipulation of Coxiella burnetii / Paul A. Beare -- Role of Innate and Adaptive Immunity in the Control of Q Fever / Christian Capo and Jean-Louis Mege -- Immune Response and Coxiella burnetii Invasion / Amira Ben Amara, Yassina Bechah and Jean-Louis Mege -- Antigenic Analysis for Vaccines and Diagnostics / Laura R. Hendrix and Chen Chen -- Epidemic Q Fever in Humans in the Netherlands / Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever and Mirjam H. A. Hermans, et al. -- Coxiella-like Endosymbionts / Jianmin Zhong -- Molecular Typing of Coxiella burnetii (Q Fever) / Robert F. Massung, Sally J. Cutler and Dimitrios Frangoulidis.Also available: Print – 2012
- 2010Matthew Jordan Goldstein.Despite the success of passive immunotherapy with monoclonal antibodies (mAb) directed against tumor cells (e.g. anti-CD20, rituximab), many lymphoma patients eventually relapse. Active immunotherapy for the treatment of lymphoma aims to induce an adaptive and long-lasting antitumor immune response to prevent or prolong time to recurrence. Although antitumor immune cells can be found in cancer patients, these cells may be rendered ineffective in eradicating cancer due to tumor-induced immunosuppression. One approach to overcome this--adoptive cell therapy--involves the isolation of tumor-specific T cells followed by their re-administration to a patient after a myeloablative conditioning regimen. The work discussed in this dissertation describes our studies on a novel approach to adoptive cell therapy for lymphoma. Specifically, we have investigated vaccination methods for generating tumor-reactive T cells in vivo and demonstrate a strategy to isolate this specific population. Prior work from our lab has shown that a combination of chemotherapy (CTX) plus intra-tumor injection of CpG cures a majority of tumors in the A20 mouse B cell lymphoma model. In these studies we found that it was necessary to inject CpG directly into the tumor. We concluded that CpG can have an immunostimulatory effect on either the tumor B cell or on the host APC to enhance uptake and presentation of tumor antigens thereby leading to a cytotoxic CD8 antitumor T cell response. We posited that the effectiveness of the CTX + CpG vaccination maneuver may be limited by endogenous regulatory factors of the immune system. Myeloablation eliminates many of these factors and creates an environment that is conducive to the adoptive transfer of anti-tumor lymphocytes. Transferred cells respond to homeostatic proliferation signals and repopulate 'empty' lymphocyte niches. We utilized CTX + CpG active immunization to generate anti-tumor T cells in vivo and transferred these T cells into lymphodepleted recipient mice. We refer to the preparation of these cells and subsequent transfer as 'immunotransplant'. Transferred T cells cured large and metastatic tumors. We demonstrated that tumor rejection was mediated by donor CD8 T cells. These transferred tumor-specific Teffector cells preferentially expanded, increasing the Teffector:Treg ratio in recipients. This work demonstrates that in situ vaccination is an efficient and effective means to generate T cells for adoptive therapy. The second phase of our work focused on designing an alternative strategy for generating antitumor T cells in vivo. We designed a CpG-loaded tumor cell vaccine made up of irradiated-tumor cells (a rich source of tumor antigens) loaded with CpG. The T cells induced by this vaccine could mediate antitumor immune responses and were more effective when adoptively transferred into lymphodepleted mice. CpG-loaded tumor cells were phagocytosed delivering both tumor antigen and the immunostimulatory CpG molecule to APCs. These APCs then expressed increased levels of costimulatory molecules and induced T cell immunity. TLR9 was required in the APC but not in the CpG-loaded tumor cell. We demonstrate that T cells induced by this vaccine were effective in adoptive cellular therapy for lymphoma and led to regression of large and established tumors. Interestingly, this therapeutic effect could be transferred by CD4 but not by CD8 T cells. This CpG-loaded whole cell vaccination has strong potential for translation to the clinical setting. We were surprised that our CpG-loaded tumor cell vaccine induced an antitumor CD4 T cell response. To date, the field of adoptive cell therapy has focused primarily on CD8 CTLs and our early work with CTX + CpG vaccination supported this paradigm. However, the concept of CD4 T cells coordinating broad, antitumor responses is important for the field of adoptive therapy. CD4 cells play central roles in nearly all aspects of the adaptive immune response including the recruitment of other immune cell types as well as the activation of B cells and APCs. However, clinical translation of using CD4 T cells for adoptive therapy is limited by potential to co-transfer regulatory CD4 T cells (Tregs). In the third phase of our work, we identified a method for isolating viable antitumor CD4 T cells while excluding Tregs based on two surface markers--CD44 and CD137. Adoptive transfer of CD137negCD44hi CD4 T cells, but not other sub-populations, provided protection from B cell lymphoma. We demonstrate that the population of CD137posCD44hi CD4 T cells consists primarily of activated Tregs. In vitro, these CD137pos cells suppressed the proliferation of effector cells in a contact-dependent manner. Moreover, in vivo the addition of CD137posCD44hi CD4 cells to CD137negCD44hi CD4 cells suppressed the antitumor immune response. These results suggest that CD137 expression on CD4 T cells defines a population of activated Tregs that prevent antitumor immune responses. Similar to observations in the murine model, human lymphoma biopsies also contain a population of CD137pos CD4 T cells that are predominantly CD25posFoxP3pos Tregs. In conclusion, our findings identify two surface markers that can be used to facilitate the enrichment of anti-tumor CD4 T cells while depleting an inhibitory Treg population. Together, these findings define a T cell-based therapy for lymphoma. We have established two methods of vaccination that are effective in generating antitumor T cells and show that these cells can reject established and metastatic tumors. T cell responses differ based on the route of vaccination, however we show that both vaccine-induced CD4 and CD8 T cells can mediate tumor rejection. Finally, we have described two surface molecules that could facilitate isolation of tumor-reactive CD4 T cells while removing tumor-reactive regulatory T cells. This work has direct implications for clinical therapy and a proof-of-concept clinical trial of adoptive immunotherapy for mantle cell lymphoma is ongoing.
- 2013Lisa Michelle McGinnis.Vascular endothelial growth factor (VEGF) signaling plays key roles in vascular development and is a therapeutic target in the treatment of malignancies. By blocking VEGF from binding to the VEGF receptor in mice pharmacologically, we show that VEGF inhibition is associated with a decrease in serum glucose levels and a suppression of hepatic glucose production. In adult wild-type mice, chronic VEGF inhibition results in lower fasting and post-prandial glucose levels and enhanced glucose tolerance. Using a hyperinsulinemic euglycemic clamp study, we find that VEGF inhibition leads to suppression of hepatic glucose production via sensitization of hepatic insulin signaling. Furthermore, gene expression analysis of livers from VEGF-inhibitor treated mice shows decreased expression of the glucose-6-phosphatase catalytic subunit (G6pc) and phosphoenolpyruvate carboxykinase (Pepck), both enzymes involved in hepatic gluconeogenesis. We also observe an up-regulation of canonical HIF-2[alpha] target genes in livers from VEGF inhibited mice, and find that HIF-2[alpha] is required for VEGF-inhibitor mediated suppression of hepatic glucose production as mice genetically lacking hepatic Hif2[alpha] (Hif2[alpha]flox/flox Albumin Cre recombinase) do not have the enhanced glucose tolerance and hypoglycemia observed in wild-type mice. Furthermore, mice treated with an adenovirus expressing a constitutively active Hif-2[alpha] allele (Ad-Hif2[alpha]PN) results in a phenocopy of VEGF inhibitor treated mice, indicating that activation of HIF-2[alpha] mediated signaling is not only necessary but also sufficient for suppression of hepatic gluconeogenesis. Western blot analysis of liver extracts from VEGF inhibitor treated mice show increased levels of two key downstream mediators of insulin receptor signaling, insulin receptor substrate 2 (IRS-2) and phosphorylated-Akt (p-Akt) when compared with controls. In fact, Ad-Hif2[alpha]PN requires Irs-2 expression to sensitize insulin signaling in primary hepatocytes, since shRNA mediated depletion of IRS-2 reduces the expected phosphorylation of Akt in response to exogenous insulin stimulation. Furthermore, we show that Hif2[alpha]PN suppresses expression of Srepb-1c, a negative regulator of Irs-2, thereby increasing expression of Irs-2. To address whether modulation of HIF-2[alpha] activity by VEGF-inhibitors may be a potential therapeutic target in diabetes, we treated diabetic, insulin resistant db/db mice with VEGF inhibitors and find significant improvement in glucose tolerance, decreases in fasting as well as post-prandial glucose levels and correction of hyperinsulinemia in a Hif-2[alpha]-dependent manner. In summary, we present evidence of crosstalk between hypoxia and insulin signaling pathways via HIF-2[alpha] modulation and that stimulation of hepatic HIF-2[alpha] may be a therapeutic target for treating type II diabetes. A second focus of this thesis examines the role of HIF-2[alpha] in mediating the ability of VEGF inhibitors to increase hematocrit. We show that VEGF inhibitors increase hematocrit in both hepatic Hif-2[alpha]-independent and --dependent ways. VEGF inhibitors require hepatic Hif-2[alpha] to induce hepatic erythropoietin (EPO)-dependent erythrocytosis and polycythemia. Conditional inactivation of hepatic Hif-2[alpha] suppresses the ability of VEGF inhibitors to increase hepatic Epo expression, reticulocytosis and hematocrit. VEGF inhibitors also increase hematocrit through a contraction in blood plasma volume in an EPO- and Hif-2[alpha]-independent manner. This thesis demonstrates that hepatic HIF-2[alpha] has essential roles both in modulating carbohydrate metabolism and inducing expression of Epo. These activities can be manipulated by treatment with VEGF inhibitors.
- 2007 SpringerPeter D. Katsikis, Bali Pulendran, Stephen P. Schoenberger, editors.Signal transduction in DC differentiation: winged messengers and Achilles' heel / Inna Lindner ... [et al.] -- Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation / Gabrielle T. Belz ... [et al.] -- Understanding the role of innate immunity in the mechanism of action of the live attenuated yellow fever vaccine 17D / Troy D. Querec and Bali Pulendran -- The function of local lymphoid tissues in pulmonary immune responses / Juan Moyron-Quiroz ... [et al.] -- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity / Jian-Ming Li and Edmund K. Waller -- It's only innate immunity but I like it / Emanuela Marcenaro ... [et al.] -- Innate tumor immune surveillance / Mark J. Smyth, Jeremy Swann, and Yoshihiro Hayakawa -- Regulation of adaptive immunity by cells of the innate immune system: bone marrow natural killer cells inhibit T cell proliferation / Prachi P. Trivedi ... [et al.] -- Induction and maintenance of CD8+ T cells specific for persistent viruses / Ester M.M. van Leeuwen, Ineke J.M. ten Berge, and René A.W. van Lier -- Germinal center-derived B cell memory / Craig P. Chappell and Joshy Jacob -- CD28 and CD27 costimulation of CD8+ T cells: a story of survival / Douglas V. Dolfi and Peter D. Katsikis -- CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses / Santiago Partida Sánchez ... [et al.] -- Vascular leukocytes: a population with angiogenic and immunosuppressive properties highly represented in ovarian cancer / George Coukos ... [et al.] -- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells / Alexandre Corthay -- Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi / Teresa Zelante ... [et al.].Also available: Print – 2007
- 2009 SpringerStephen P. Schoenberger, Peter D. Katsikis, Bali Pulendran, editors.Protective effects of type1 interferon in models of intestinal inflammation / Jongdae Lee ... [et al.] -- NK/DC complot / Emanuela Marcenaro ... [et al.] -- Detection of microbes by natural killer T cells / Yuki Kinjo, Mitchell Kronenberg -- Ontogeny of the secondary antibody response, origins and clonal diversity / Craig P. Chappell, Joseph Dauner, Joshy Jacob -- Role of PI3K signalling in the B cell response to antigen / Daniel J. Hodson, Martin Turner -- CD28, old dog, new tricks / Jayakumar R. Nair, Cheryl Rozanski, Kelvin P. Lee -- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection / Thomas Wirth, John T. Harty -- Effects of cancer immunotherapy regimens on primary vs. secondary immune responses and the potential impact on long-term antitumor responses / Kory L. Alderson, William J. Murphy -- New insights into classical costimulation of CD8+ T cell responses / Christine M. Bucks, Peter D. Katsikis -- Peripheral tolerance induction by lymph node stroma / Erika D. Reynoso, Je-Wook Lee, Shannon J. Turley.Also available: Print – 2009
- 2011 Springeredited by Peter D. Katsikis, Bali Pulendran and Stephen P. Schoenberger.Is transcription the dominant force during dynamic changes in gene expression? -- MicroRNAs: key components of immune regulation -- KIR/HLA: genetic clues for a role of NK cells in the control of HIV -- Natural killer cell licensing during viral infection -- Bridging innate NK cell functions with adaptive immunity -- Control of innate immunity by memory CD4 T cells -- Strategies and implications for prime-boost vaccination to generate memory CD8 T cells -- Blimp1: driving terminal differentiation to a T -- New role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis -- Impact of differential glycosylation on IgG activity -- Murine model of chronic respiratory inflammation -- Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1 -- Influenza vaccines: what do we want and how can we get it?Also available: Print – 2011
- 2013 SpringerPeter D. Katsikis, Stephen P. Schoenberger, Bali Pulendran, editors.
- 2015 SpringerPeter D. Katsikis, Stephen P. Schoenberger, Bali Pulendran, editors.1. Type III interferons (IFNs): emerging master regulators of immunity -- 2. Stability of regulatory T cells undermined or endorsed by different type-1 cytokines -- 3. The role of Il-12 and type I interferon in governing the magnitude of CD8 T cell responses -- 4. Functional diversity of human dendritic cells -- 5. Selective dependence of kidney dendritic cells on CX3CR1, implications for glomerulonephritis therapy -- 6. Mechanisms of memory T cell activation and effective immunity -- 7. Molecular programming of immunological memory in natural killer cells -- 8. Induction of immune tolerance to dietary antigens -- 9. The role of p110ð in the development and activation of B lymphocytes -- 10. Immune memory and exhaustion: clinically relevant lessons from the LCMV model -- Index.Also available: Print – 2015
- 2011 Future Mededitor, Mario Cicardi.Hereditary angioedema in 2011 / Marco Cicardi -- Hereditary angioedema : diagnosis and pathogenic mechanisms / Allen P. Kaplan -- Current options for the acute treatment and prophylaxis of hereditary angioedema / Laraib Tabba & Timothy J. Craig -- Novel C1 inhibitors for hereditary angioedema / Henriette Farkas & Lilian Varga -- New drug targets and future direction : ecallantide / Jonathan A. Bernstein -- New drug targets and future direction : icatibant / Konrad Bork -- Index.
- 2014 Future Mededitor, Cristoforo Incorvaia.Current approaches to allergic rhinitis / Cristoforo Incorvaia -- Allergic rhinitis : symptoms / Nerin N. Bahceciler & Nilufer Galip -- Allergic rhinitis : causes and pathogenesis / Giovanni Passalacqua -- Diagnostic tests in allergic rhinitis / Cristoforo Incorvaia & Franco Frati -- Nasal steroids in allergic rhinitis / Davide Caimmi, Silvia Caimmi, Roberto Raschetti, Ilaria Brambilla & Gian Luigi Marseglia -- Other treatments / Takeshi Nabe -- Index.
- 2006 SpringerA. Radbruch and P.E. Lipsky (eds.).
- 1991- Wileyedited by John E. Coligan ... [et al.].ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.Also available: Print – v. 1-6, 1991-2010.
- 2006 Springeredited by John D. Lambris.1. Cross-disciplinary research stirs new challenges into the study of the structure, function, and systems biology of complement / Dimitrios Mastellos and John D. Lambris -- 2. Liver regeneration: a link to inflammation through complement / Robert A. DeAngelis, Maciej M. Markeiwski, and John D. Lambris -- 3. The Role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow / Ryan Reca ... [et al.] -- 4. Complement system and the eye / Purushottam Jha ... [et al.] -- 5. To regeneration ... with complement / Panagiotis A. Tsonis, John D. Lambris, and Katia Del Rio-Tsonis -- 6. Self, non-self and danger: a complementary view / Jörg Köhl -- 7. gClqR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation / Berhane Ghebrehiwet ... [et al.] -- 8. Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer? / Kristina Nilsson Ekdahl ... [et al.] -- 9. Diversified components of the bony fish complement system: more genes for robuster innate defense? / Miki Nakao ... [et al.] -- 10. C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection / Horea Rus, Cornelia Cudrici, and Florin Niculescu -- 11. The Double-edged flower: roles of complement protein C1q in neurodegenerative diseases / Andrea J. Tenner and Maria I. Fonseca -- 12. The Role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis / Nóra Terényi, József Prechl, and Anna Erdei -- 13. The Complement system: a potential target for stroke therapy / J. Mocco ... [et al.] -- 14. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia / Fletcher B. Taylor, Jr., Eric Hack, and Florea Lupu -- 15. Complement activation during sepsis in humans / Heike Schreiber ... [et al.] -- 16. Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects / Yee-Ling Wu ... [et al.] -- 17. A Minimum CR2 binding domain of C3d enhances immunity following vaccination / Joseph F. Bower and Ted M. Ross -- 18. Structure and function of ficolins / Yuichi Endo, Yu Liu, and Teizo Fujita -- 19. Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM) / Lieve Nuytinck ... [et al.] -- 20. Conformational complexity of complement component C3 / Bert J.C. Janssen and Piet Gros -- 21. Disease-associated sequence variations in factor H: a stuctural biology approach / Andrew P. Herbert ... [et al.] -- 22. Transdermal pharmacology of small molecule cyclic C5a antagonists / Lavinia M. Proctor ... [et al.] -- 23. Inactivation of complement by recombinant human C3 derivatives / Edzard Spillner, Johanna Kölln, and Reinhard Bredehorst -- 24. Complement analysis in clinic and research / Tom E. Mollnes and Michael Kirschfink -- 25. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers / Sarah J. Calano ... [et al.].
- 2007 Springeredited by John D. Lambris.Also available: Print – 2007
- 2012 SpringerJohn D. Lambris, George Hajishengallis, editors.Pentraxins in Humoral Innate Immunity / Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino and Alberto Mantovani -- Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution / Gerardo R. Vasta -- The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells - An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids / Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin and Ewa Bryndza, et al. -- Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds / Elizabeth A. Grice and Julia A. Segre -- Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity / George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh and John D. Lambris -- A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects / Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo and John Trowsdale, et al. -- Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins / Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris and Brian V. Geisbrecht -- Granzyme B: A New Crossroad of Complement and Apoptosis / Mario Perl, Stephanie Denk, Miriam Kalbitz and Markus Huber-Lang -- Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis / Markus Bosmann and Peter A. Ward -- Complement Involvement in Neovascular Ocular Diseases / Ryoji Yanai, Aristomenis Thanos and Kip M. Connor -- Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis / Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson and Kristina N. Ekdahl -- Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection / Qingguo Ruan and Youhai H. Chen -- Function of Act1 in IL-17 Family Signaling and Autoimmunity / Ling Wu, Jarod Zepp and Xiaoxia Li -- Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood / D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris and T. Espevik, et al. -- Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases / Beatriz Novoa and Antonio Figueras -- Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection / Heidi A. Schreiber and Matyas Sandor -- NK/DC Crosstalk in Anti-viral Response / Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta and Simona Sivori -- Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS / Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee and Matyas Sandor, et al. -- Nutritional Immunity: Homology Modeling of Nramp Metal Import / Mathieu F. M. Cellier.Also available: Print – 2012
- v. 285-398, 2005-16. SpringerAlso available: Print – v. 40-241, 243-, 1967-99, , 2001-
- 2005 SpringerAnnegret Kuhn, Percy Lehmann, Thomas Ruzicka, eds.Also available: Print – 2005
- 2014 Springer Protocolsedited by Ivana Vancurova.Control of pro-inflammatory cytokine release from human monocytes with the use of an interleukin-10 monoclonal antibody / Hardik Patel and Dennis Davidson -- Cytokine-induced neutrophil chemotaxis assay / Dennis Davidson and Hardik Patel -- In vitro one-dimensional assay to study growth factor-regulated tumor cell-macrophage interaction / Ved P. Sharma, Brian T. Beaty, Dianne Cox, John S. Condeelis, and Robert J. Eddy -- Chemotactic responses by macrophages to a directional source of a cytokine delivered by a micropipette / Michael Cammer and Dianne Cox -- Assessment of phagocytic activity of cultured macrophages using fluorescence microscopy and flow cytometry / Lokesh Sharma ... [e tal.] -- Assessment of cytokine-modulated proteasome activity / Christopher J. Kirk, Saul R. Powell, and Edmund J. Miller -- Evaluation of the adverse effect of low concentration of cadmium on interleukin-4 induced class switch recombination in burkett's lymphoma Raji cell line / Vladimir Poltoratsky -- Mix-and-measure assay for determining the activation status of endogenous Cdc42 in cytokine-stimulated macrophage cell lysates / Veronika Miskolci ... [et al] -- Analysis of the cell surface expression of cytokine receptors using the surface protein biotinylation method / Mahmud Arif Pavel -- Detection of CXCR2 cytokine receptor surface expression using immunofluorescence / Clarissa Lam ... [et al.] -- Detecting Tie2, an endothelial growth factor receptor, by using immunohistochemistry in mouse lungs / Prajna P. Guha, Sascha A. David, and Chandra C. Ghosh -- Use of shRNA for stable suppression of chemokine receptor expression and function in human cancer cell lines / Nicole Salazar ... [et al.] -- Intracellular staining and detection of cytokines by fluorescence-activated flow cytometry / Giulia Freer -- Cytokine detection by flow cytometry / Jian-Ge Qiu ... [et al.] -- Analysis of IL-17 production by flow cytometry and ELISPOT assays / Ling Zhao ... [et al] -- Interleukin-1 (IL-1) immunohistochemistry assay in oral squamous cell carcinoma / Takaaki Kamatani -- Immunofluorescence and subsequent confocal microscopy of intracellular TNF in human neutrophils / Janet Rollins and Veronika Miskolci -- Evaluating cytoplasmic and nuclear levels of inflammatory cytokines in cancer cells by western blotting / Himavanth R. Gatla ... [et al.] -- Western analysis of intracellular interleukin-8 in human mononuclear leukocytes / Veronika Miskolci ... [et al.] -- Quantitative analysis of bortezomib-induced IL-8 gene expression in ovarian cancer cells / Bipradeb Singha ... [et al.]
- 2014 SpringerTakayuki Yoshimoto, Tomohiro Yoshimoto, editors.The Interleukin-1 Family / Charles A. Dinarello and Mihai G. Netea -- IL-6 and Inflammatory Diseases / Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura, and Masaaki Murakami -- The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders / Harumichi Ishigame and Susumu Nakae -- IL-18 / Wen Li, Yoshimasa Tanaka, and Haruki Okamura -- Interleukin-21: a Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential / Rosanne Spolski and Warren J. Leonard -- Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells / Xiaoting Wang and Wenjun Ouyang -- IL-23 in Health and Disease / Jonathan P. Sherlock, Luis A. Zuniga, and Daniel J. Cua -- IL-36: An Epithelial Cytokine Important in Psoriasis / John E. Sims, Solenne Vigne, Cem Gabay, and Jennifer E. Towne -- Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure / Jagdeep Nanchahal, Peter Taylor, Richard Williams, and Marc Feldmann -- Interleukin-25: Key Initiator of Type 2 Immune Responses / Hiroshi Nakajima, Tomohiro Tamachi, and Koichi Hirose -- Interleukin-33: Multifunctional Alarmin that Promotes Both Health and Disease / Kazufumi Matsushita and Tomohiro Yoshimoto -- Thymic Stromal Lymphopoietin (TSLP) / Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima, and Hongwei Han -- Interleukin-10: Cytokines in Anti-inflammation and Tolerence / Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova, and Anne O'Garra -- Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties / Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi, and Takayuki Yoshimoto -- Interleukin-35: A Novel Mediator of Peripheral Tolerance / Greg M. Delgoffe and Dario A.A. Vignali.
- 2007 CRCnetBASEedited by Nicholas P. Plotnikoff ... [et al.].1. Behavioral Effects of Cytokines: A Psychiatrist's Perspective / Ziad Kronfol -- 2. Worried to Death? Stress, Worry, and Immune Dysregulation in Health and HIV -- 3. Psychological Stress and Its Relationship to Cytokines and Inflammatory Diseases / Rama Murali, Margaret D. Hanson, and Edith Chen -- 4. Role of Cytokines in Depression / Ghanshyam N. Pandey and Yogesh Dwivedi -- 5. Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines / Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo -- 6. Stress, Cytokines, and Peripheral Analgesia / Peter John Cabot -- 7. Alexithymia, Stress, and Immunity / Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet -- 8. Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression / Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy -- 9. Stress, Opioid Peptides, and Immune Reponse / Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim -- 10. Met-Enkephalin in Oxidative Stress / Tihomir Balog, Sandra Soboc̆anec, Vis̆nja S̆verko, Helena Haberstock-Debić, and Tatjana Marotti -- 11. Chronic Stress Induces Death of Lymphocytes / Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi -- 12. Interleukin-10 and the Hypothalamic--Pituitary--Adrenal Axis / Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr. -- 13. Cytokines, Stress, and Depression / Adrian J. Dunn -- 14. Immunoconversion in Acute Phase Response / Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs -- 15. Interferon in Health and Disease / Nachum Dafny, Pamela B. Yang, and Stanley A. Brod -- 16. Neuropeptide Precursor Processing in Immunocytes: Involvement in Neuroimmune Communication / Robert Day and Michel Salzet -- 17.Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? / Paola Sacerdote, Sivia Franchi, and Cataldo Martucci -- 18. Human Retroviruses and the Cytokine Network / Massimo Alfano and Guido Poli -- 19. Psychiatric Toxicity of Interferon: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? -- 20. Role of Genetic Predisposition, Cytokines, and Neuroendocrine Response in Development of Thyroid Autoimmunity / Antonio Martocchia and Paolo Falaschi -- 21. Gender Differences, Stress, and Immunity / Nicholas P. Plotnikoff and Robert E. Faith.
- 2008 ScienceDirectvolume editors, Christopher Phelps, Elena Korneva.
- 2007 Springer Protocolsedited by Robert V. House, Jacques Descotes.Introduction to cytokines as targets for immunomodulation / Theresa L. Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Hervé Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James E. Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca J. Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin ... [et al.] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy ... [et al.] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- Flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana G. Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth W. Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael J. Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes.
- 2014 Springer Protocolsedited by Elena Ranieri.Negative and positive separation techniques for the isolation of antigen-specific CD8+ T cells from blood and tumor tissue / Margherita Gigante, Sharon Natasha Cox, and Elena Ranieri -- In vitro\ex vivo generation of cytotoxic T lymphocytes / Margherita Gigante and Elena Ranieri -- Phenotypic and functional characterization of cytotoxic T lymphocytes by flow cytometry / Iulia Popescu [and three others] -- Intracellular signaling of CTLs / Sharon Natasha Cox -- Monitoring antigen-specific T cell responses using real-time PCR / Devin B. Lowe, Jennifer L. Taylor, and Walter J. Storkus -- CTL ELISPOT assay / Elena Ranieri, Iulia Popescu, and Margherita Gigante -- Methods of purification of CTL-derived exosomes / Angela Montecalvo, Adriana T. Larregina, and Adrian E. Morelli -- Characterization of CTL by microscopy / Giuseppe Stefano Netti -- Intravital imaging of cytotoxic T lymphocytes / Gaetano Faleo, Per-Olof Berggren, and Antonello Pileggi -- The microarray-based approach for the analysis of the transcriptome / Matteo Accetturo, Paola Pontrelli, and Loreto Gesualdo -- miRNome analysis using real-time PCR / Paola Pontrelli, Matteo Accetturo, and Loreto Gesualdo -- Proteomic approaches by SELDI and MALDI-TOF/MS for CTL analysis / Massimo Papale and Maria Teresa Rocchetti -- Two-dimensional gel electrophoresis approach for CTL phosphoproteome analysis / Maria Teresa Rocchetti, Massimo Papale, and Loreto Gesualdo -- Targeting the JAK/STAT pathway in cytotoxic T lymphocytes (CTL) by next generation sequencing (NGS) / Maddalena Gigante, Sterpeta Diella, and Elena Ranieri -- Experimental model for studying the involvement of regulatory cytotoxic T cells in bone resorption / Giacomina Brunetti [and three others] -- CTL and transplantation : tissue in vivo characterization / Federica Rascio, Chiara Divella, and Giuseppe Grandaliano.
- 2007 SpringerElling Ulvestad.
- 2009 Springercontributors, L. Adorini ... [et al.] ; Giovanna Lombardi, Yanira Riffo-Vasquez, editors.
- 2009 SpringerMichael R. Shurin, Russell D. Salter, editors.The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
- 2008 SpringerM. Onji, S.M.F. Akbar.
- 2008 Kargervolume editors, Brian J. Nickoloff, Frank O. Nestle.Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
- 2012 SpringerAlexander von Gabain, Christoph Klade, editors.Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
- 2014 SpringerFriedemann Kiefer, Stefan Schulte-Merker, editors."For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher's description.
- 2011 SpringerPéter Balogh, editor.Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
- v. 39, 2005. SpringerAlso available: Print – v. 2, 5, 10-11, 17, 29, 1982, 1984-85, 1987, 1994.
- 2015 SpringerPaolo A. Ascierto, David F. Stroncek, Ena Wang, editors.1. New insight of peptide vaccination in cancer immunotherapy -- 2. The determinants of T cell function for effective anticancer vaccine -- 3. T cell fate in the tumor microenvironment -- 4. T cell receptor avidity and affinity and tumor specific TCR engineer -- 5. Host genetic variation and somatic alteration associated with favorable or compromised T cell function -- 6. Production of Clinical T Cell Therapies -- 7. Clinical success of adoptive cell transfer therapy using tumor infiltrating lymphocytes.-8. Harnessing stem cell-like memory T cells for adoptive cell transfer therapy of cancer -- 9. T cell blockade- anti-CTLA4 immunotherapy against cancer and Abscopal effect in combination therapy -- 10. T cell modulation- anti-OD-1 antibodies for the treatment of cancer -- 11. T cell based therapies in combination with other procedures -- 12. Chimeric antigen receptor T cells CD19 CAR -- 13. Hematopoietic Stem Cell transplantation as immune therapy of malignancies.
- Adenosine receptors : therapeutic aspects for inflammatory and immune diseases — Developments in T cell based cancer immunotherapies (162)
- Diagnostic imaging of infections and inflammatory diseases : a multidisciplinary approach — Immunology of pregnancy (162)
- Immunology of the female genital tract — Neuroinflammation and CNS disorders (162)
- Neutrophil methods and protocols. Second edition. [2nd ed.] — Wiley-Blackwell handbook of psychoneuroimmunology (159)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
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- Primary Care Medicine
- Campbell-Walsh Urology
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