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Allergy and Immunology

  • Advances in anaphylaxis management / Denise Anne Moneret-Vautrin -- Anaphylaxis : classification and clinical symptoms / Johannes Ring, Jarmila Liptak & Knut Brockow -- Pathophysiology : IgE-mediated and non-IgE-mediated anaphylaxis / Denise Anne Moneret-Vautrin -- Risk factors for fatal anaphylaxis / Richard Pumphrey & Gunter Sturm -- Etiologies of anaphylaxis / Margitta Worm -- Biomarkers for the evaluation of severity of anaphylaxis / Julia Upton & Peter Vadas -- Role of specific IgE testing in allergy diagnosis / Sandrine Jacquenet, Denise-Anne Moneret-Vautrin & Bernard E. Bihain -- Treatment algorithm for anaphylaxis and prognosis / Ben Gibbison & Jasmeet Soar -- Food anaphylaxis prevention / Martine Morisset -- Hymenoptera anaphylaxis : indications and results of immunotherapy / Ulrich R. Müller & Arthur Helbling -- Index.
  • Over the past decade, enormous progress has been made in understanding the late events in the HIV replication cycle. This has been made possible by major advances in cell biology, virology, and structural biology. The field continues to move forward rapidly, with important new discoveries being reported on a regular basis. The impact of this progress across a broad spectrum of biomedical research has been substantial. The increase in basic knowledge in the areas of HIV assembly, release, and maturation has been accompanied by new possibilities for therapeutic intervention.The work includes topics relating to basic molecular biology, cell biology, and structural biology of HIV assembly, coupled with more applied ideas of how this basic information can inform the field of antiretroviral research. The book covers all major topics pertaining to the late stages of HIV replication, with leaders in each area recruited to contribute chapters in their areas of expertise . The topics will be sufficiently focused to allow authors the opportunity to cover the latest developments in detail.
  • Recent advances in understanding of fundamental immunology have created new insights into the dynamic interactions between tumors and the immune system. This includes new understanding of T- and B-cell interaction, immune inhibitory mechanisms including the biology of T regulatory cells, myeloid suppressor cells, and dendritic cell subsets. Enhanced understanding of mechanisms underlying T-cell anergy such as arginine deprivation, immunosuppressive cytokines, defective innate and interferon response pathways, and NKG2D downregulation have all provided new insight into suppression of anti-tumors.
  • "The skin is one of the most frequently involved organs in adverse drug reactions. Occurring with an incidence of 1 to 5 percent for certain types of drugs, cutaneous drug eruptions are mostly benign in nature, and comprise the maculopapular type of eruption and urticaria. However, about one third of them require hospital treatment, leading to a considerable burden for the health care system. In this book, a selected group of experts provide an up-to-date, condensed and clinically relevant overview of the field of cutaneous drug eruptions, ranging from epidemiology and genetic predisposition to available therapeutic measures, including rapid drug desensitization. Reflecting the great progress made in recent years in this field, this publication will be a useful tool for a better understanding, diagnosis and management of cutaneous drug eruptions, not only for general physicians, dermatologists and clinical allergologists, but also for nurses and scientists." -- publisher's site.
  • Respiratory allergy is constantly encountered and is sharply on the rise, particularly in the two most vulnerable age-groups: young children and seniors. Allergy results in airway hyperactivity and increased airway resistance, with all inflammatory sequelae being ensued. The chapters show how respiratory allergy research is interconnected with other disciplines by discussing neurotransmitter, membrane receptor, and ionic channel mechanisms of allergy and by giving diagnostic and pharmacological cues on desensitization and therapy.
  • Allergic disease: pathophysiology and immunopathology -- Approach to the allergic patient -- Diagnostic tests in allergy -- Environmental allergens -- Anaphylaxis -- Insect sting allergy -- The child with asthma -- Asthma in adults: diagnosis and management -- Allergic rhinitis: diagnosis and treatment -- Sinusitis and otitis media -- Diagnosis and treatment of ocular allergy -- Urticaria and angioedema -- Atopic dermatitis -- Contact dermatitis and other contact reactions -- Food allergy and intolerance -- Allergic and allergic-like reactions to drugs and other therapeutic agents -- Antihistamines -- β-adrenergic agonists -- Theophylline -- Antileukotriene agents in the management of asthma -- Cromolyn and nedocromil: nonsteroidal anti-inflammatory therapy for asthma and other allergic diseases -- Anticholinergic agents in respiratory diseases -- Glucocorticoid therapy in asthma -- Anti-IgE therapy -- Environmental control of respiratory indoor allergens -- Allergen immunotherapy -- Controversies in allergy and allergy-like diseases -- The patient with 'too many infections'.
  • Relations between asthma and psychological distress: an old idea revisited -- Brain and asthma: what are the linkages? -- Stress-related programming of autonomic imbalance: role in allergy and asthma -- Role of parasympathetic nerves and muscarinic receptors in allergy and asthma -- Developmental programming of allergic diseases -- Mind-body interrelationship in DNA methylation -- Neurotrophins in chronic allergic airway inflammation and remodeling -- Pathways underlying afferent signaling of bronchopulmonary immune activation to the central nervous system -- Allergen-induced neuromodulation in the respiratory tract -- Role of microbiome in regulating the HPA axisd and its relevance to allergy -- Autonomic regulation of anti-inflammatory activities from salivary glands -- Mast cell-nerve functional unit: a key component of physiologic and pathophysiologic responses -- Neural and behavioral correlates of food allergy -- Neuroendocrine-immune connection regulates chronic inflammatory disease in allergy -- Itch and the brain.
  • Allergy frontiers v. 1-6, 2009-2010.
    v. 2, 2009 Springer
    v. 3, 2009 Springer
    v. 4, 2009 Springer
    v. 5, 2010 Springer
    v. 6, 2010 Springer
    v. 1. Epigenetics, allergens and risk factors -- v. 2. Classification and pathomechanisms -- v. 3. Clinical manifestations -- v. 4. Diagnosis and health economics -- v. 5. Therapy and prevention -- v. 6. Future perspectives.
  • Allergy methods and protocols 2008
    Springer Protocols
    Understanding of the molecular mechanisms of allergy / Meinir Jones -- T cell : primary culture from peripheral blood / Monika Raulf-Heimsoth -- Production of T-cell lines / Helga Kahlert -- Production of human T-cell clones / Adrienne Verhoef -- Mapping of human T-cell epitopes of allergens / Thomas Zeiler and Tuomas Virtanen -- Determining MHC restriction of T-cell responses / Mark Larché -- Short-term culture of CD8 cells and intracellular cytokine staining / Beejal Vyas and Alistair Noble -- Isolation, flow cytometric analysis, and suppression assay of CD4+ CD25+ T-regulatory cells / Hayley Jeal -- Monocyte-derived dendritic cells as antigen-presenting cells in T-cell proliferation and cytokine production / Sun-sang J. Sung -- Ultrasensitive ELISA for measurement of human cytokine responses in primary culture / William P. Stefura ... [et al.] -- Quantification of human chemokine production in TLR-stimulated and antigen-specific recall responses / Monique Stinson ... [et al.] -- Standardization of allergen extracts / Jørgen Nedergaard Larsen and Sten Dreborg -- Immunoelectrophoresis for the characterization of allergen extracts / Gitte Nordskov Hansen and Jørgen Nedergaard Larsen -- Conjugation of haptens / Ranulfo Lemus and Meryl H. Karol -- Monoclonal antibodies / Helga Kahlert and Oliver Cromwell -- Purification of antibodies / Per H. Larsson -- Collection of air samples to quantify exposure to airborne allergens / Susan Gordon -- Assay of air sample eluates / Anne Renström and Susan Gordon -- The halogen assay : a new technique for measuring airborne allergen / Euan Tovey ... [et al.] -- Measurement of specific IgG anti-Fel d 1 antibodies / Meinir G. Jones -- The facilitated antigen binding (FAB) assay : a protocol to measure allergen-specific inhibitory antibody activity / James N. Francis -- Microscopic identification and purity determination of pollen grains / Magdalena Rahl -- Biopanning for the characterization of allergen mimotopes / Isabella Pali-Schöll and Erika Jensen-Jarolim -- Identification of mast cells and mast cell subpopulations / Mark Buckley and Andrew F. Walls -- Purification and characterization of mast cell tryptase and chymase from human tissues / Alan R. McEuen and Andrew F. Walls -- Experimental activation of mast cells and their pharmacological modulation / Shaoheng He and Andrew F. Walls -- In situ hybridization / Kayhan T. Nouri-Aria.
  • Allergy. 4th ed. 2012
    2011 ClinicalKey
    The new edition of Allergy, by Drs. Stephen Holgate, Martin Church, David Broide, and Fernando Martinez, uses an enhanced clinical focus to provide the clear, accessible guidance you need to treat allergy patients. A more consistent format throughout features new differential diagnosis and treatment algorithms, updated therapeutic drug information in each chapter, and additional coverage of pediatric allergies. With current discussions of asthma, allergens, pollutants, drug treatment, and more, as well as access to the full text and illustrations online at, this comprehensive resource is ideal for any non-specialist who treats patients with allergies. Prescribe appropriate therapies and effectively manage patients' allergies using detailed treatment protocols. Identify allergic conditions quickly and easily with algorithms that provide at-a-glance assistance. Explore topics in greater detail using extensive references to key literature.
  • Anaphylaxis 2010
    History and epidemiology -- History and classification of anaphylaxis -- Epidemiology of anaphylaxis -- Mechanisms -- T-cell response to allergens -- Anaphylaxis: mechanisms of mast cell activation -- Kinins, airway obstruction, and anaphylaxis -- Role for basophils in systemic anaphylaxis -- Human cardiac mast cells in anaphylaxis -- Diagnosis and clinical symptomatology -- Mastocytosis -- In vitro diagnosis of anaphylaxis -- Allergens and elicitors -- Insect venoms -- Classification and pathophysiology of radiocontrast media hypersensitivity -- Analgesics -- Anaphylaxis to general anesthetics -- Anaphylactic reactions to local anesthetics -- Treatment and prevention -- Anaphylaxis: acute treatment and management -- Epinephrine (adrenaline) in anaphylaxis.
  • Definition and criteria for the diagnoses of anaphylaxis -- An epidemiological approach to reducing the risk of fatal anaphylaxis -- Pathophysiology and organ damage in anaphylaxis -- Mast cells: effector cells of anaphylaxis -- Basophils in anaphylaxis -- Protease mediators of anaphylaxis -- Aspirin and NSAID reactions: diagnosis, pathophysiology, and management -- IgE-dependent and independent effector mechanisms in human and murine anaphylaxis -- Food-induced anaphylaxis -- Antibiotic-induced anaphylaxis -- Anaphylaxis during radiological procedures and in the peri-operative setting -- Hymenoptera-induced hypersensitivity reactions and anaphylaxis -- Idiopathic anaphylaxis -- Exercise-induced anaphylaxis and food-dependent exercise-induced anaphylaxis -- Mastocytosis and mast cell activation syndromes presenting as anaphylaxis -- Anaphylaxis in mastocytosis -- Flushing and urticarial syndromes presenting as anaphylaxis -- Pharmacologic management of acute anaphylaxis -- Drug desensitizations in the management of allergy and anaphylaxis to chemotherapeutic agents and monoclonal antibodies -- Rapid desensitizations for antibiotic-induced hypersensitivity reactions and anaphylaxis -- Induction of tolerance for food-induced anaphylaxis -- Management of anaphylaxis: relevance of causes and future trends in treatment.
  • History of research on angiogenesis -- Immune cells as a source and target of angiogenic and lymphangiogenic factors -- Neuropilins: role in signalling, angiogenesis and disease -- Class 3 semaphorin in angiogenesis and lymphangiogenesis -- Angiogenic and antiangiogenic chemokines -- Role of uPA/uPAR in the modulation of angiogenesis -- Neutrophil-derived cytokines involved in physiological and pathological angiogenesis -- Roles of eosinophils in the modulation of angiogenesis -- Regulatory T cells, leptin and angiogenesis -- Angiogenesis as a therapeutic target for obesity and metabolic diseases -- Angiogenesis in multiple myeloma -- Angiogenesis inhibitors in the treatment of prostate cancer -- Therapeutic perspectives in vascular remodeling in asthma and chronic obstructive pulmonary disease.
  • Antibody Fc is the first single text to synthesize the literature on the mechanisms underlying the dramatic variability of antibodies to influence the immune response. The book demonstrates the importance of the Fc domain, including protective mechanisms, effector cell types, genetic data, and variability in Fc domain function. This volume is a critical single-source reference for researchers in vaccine discovery, immunologists, microbiologists, oncologists and protein engineers as well as graduate students in immunology and vaccinology.
  • Many pathogens and aberrant malignant cells express unique carbohydrates on their surface representing attractive targets for vaccine design. Considerable progress has recently been made in the identification of novel carbohydrate based vaccines and a large number has reached clinical phase studies. The success of several licensed carbohydrate based vaccines against bacterial pathogens such as Haemophilus influenzae type b, Neisseria meningitidis or Streptococcus pneumoniae demonstrates their great potential. However, the study of anti-carbohydrate antibodies is technically challenging and partly because of low affinities and promiscuous specificity they have not been medically exploited to full potential. The study of antibody specificities and identification of protective carbohydrate epitopes lies at the heart of successful vaccine design. In addition to therapy, antibodies in general serve as diagnostic tools in medical and scientific laboratories. In this setting high affinity and exquisite specificity are important factors for their successful use. ãaAnticarbohydrate Antibodies ãa from molecular basis to clinical applicationãa compiles current knowledge on the immunological recognition of carbohydrates by the adaptive immune system from a molecular perspective providing fundamental insight needed for advancing clinically relevant diagnostics and therapeutic applications. Based on significant progress in the fields of glycoimmunology and structural biology in recent years, the book comprehensively reviews the state-of-the-art in defining the key elements of carbohydrate recognition by antibodies, the molecular mimicry of carbohydrate epitopes as well as the molecular features leading to specific and relaxed binding modes. Backed-up by a combination of modern technologies to elucidate structural details of carbohydrate-antibody interactions, biomedically important carbohydrate antigens from viral, bacterial, parasite, insect and tumor cells have been analyzed in in-depth reviews written by well-known experts in the field. Fundamental knowledge of these molecular mechanisms eventually provides a rational basis to improve efficacy of carbohydrate-based vaccines and to further refine diagnostic tools in detection of pathogens and malignant cells.
  • Evolution of Antimicrobial Peptides: A View from the Cystine Chapel -- Innate Immunity in Plants: The Role of Antimicrobial Peptides -- Antimicrobial Peptides Produced by Microorganisms -- LL-37: An Immunomodulatory Antimicrobial Host Defence Peptide -- Wound Repair and Antimicrobial Peptides -- WAPing Out Pathogens and Disease in the Mucosa: Roles for SLPI and Trappin-2 -- Histatins: Multifunctional Salivary Antimicrobial Peptides -- Structure-Function Relationships of Antimicrobial Chemokines -- Mechanisms and Significance of Bacterial Resistance to Human Cationic Antimicrobial Peptides -- Antimicrobial Peptides and Inflammatory Bowel Disease -- Cystic Fibrosis and Defective Airway Innate Immunity -- Antimicrobial Peptides in Chronic Obstructive Pulmonary Disease -- Host Defense Peptides: Immune Modulation and Antimicrobial Activity In Vivo -- Helping the Host: Induction of Antimicrobial Peptides as a Novel Therapeutic Strategy Against Infections.
  • This book, part of the series Rare Diseases of the Immune System, offers comprehensive, up-to-date coverage of the pathophysiology and management of the antiphospholipid syndrome (APS). Immunologic and genetic aspects are discussed and the pathogenic mechanisms responsible for such phenomena as APS-mediated thrombosis and pregnancy loss or complications are explained. The main clinical manifestations and classification criteria are described and diagnostic tools, identified. Close attention is paid to the nature of the involvement of other organs or organ systems in APS, including the nervous, endocrine, hematologic, cardiovascular, and gastrointestinal systems, the kidney, the skin, and the eye. Specific chapters describe the treatment of the different symptoms, the preventive therapies of value in avoiding recurrences, and innovative treatment approaches. The authors are senior experts in the field who are aided by younger fellows, ensuring that the book is also educationally oriented. This handy volume will be a valuable tool for postgraduates in training and professionals wishing to extend their knowledge of this specific syndrome
  • History / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Epidemiology / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Antiphospholipid Antibodies / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Classification Criteria for APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Mortality, Morbidity, and Damage Associated with aPL / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differences Between Primary and Secondary APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Clinical Features / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- aPL and Transplantation / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Differential Diagnosis / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta -- Management of APS / Maria Laura Bertolaccini, Oier Ateka-Barrutia and Munther A. Khamashta.
  • Part 1. History of Antiphospholipid Syndrome -- 1. Overview of the Last 25 Years and 13 International Congresses on Antiphospholipid Antibodies / Eon Nigel Harris and Silvia S. Pierangeli -- Part II. Basic Science Aspects of Antiphospholipid Syndrome -- 2. What is the Oirgin of Antiphospholipid Antibodies? / Rohan Willis, Yehuda Shoenfeld, Silvia S. Pierangeli and Miri Blank -- 3. What is the Genetics of Antiphospholipid Antibodies/Syndrome? / Thomas L. Ortel, Pier Luigi Meroni, Marta E. Alarcón-Riquelme, Maria O. Borghi and Joan T. Merrill -- 4. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Thrombosis? / Rohan Willis, Ian P. Giles, Pojen P. Chen, Chary López-Pedrera and María José Cuadrado, and Silvia S. Pierangeli -- 5. What is the Mechanism(s) of Antiphospholipid Antibody-Mediated Pregnancy Morbidity? / Vikki M. Abrahams, Maria O. Borghi, Pier Luigi Meroni, Jacob H. Rand, Elena Raschi, Jane E. Salmon, Francesco Tedesco, and Angela Tincani -- 6. What are the Target Cells and Receptors that are Recognized by Antiphospholipid Antibodies? / Philip G. de Groot, Elena Raschi, Keith R. McCrae, Silvia S. Pierangeli, Panayiotis G. Vlachoyiannopoulos, and Rolf T. Urbanus -- Part 3. 13th Iinternational Congress on Antiphospholid Antibodies Task Force Reports -- 7. Task Force Report on "Criteria" Antiphospholipid Antibody Tests / Robert A. S. Roubey and Silvia S. Pierangeli -- 8. Task Force Report on "Non-criteria" Antiphospholipid Antibody Tests / Maria Laura Bertolaccini, Olga Amengual, Tatsuya Atsumi, Walter L. Binder, William H. Kutteh, Bas de Laat, [and others] -- 9. Task Force Report on Obstetric Antiphospholipid Syndrome / D. Ware Branch, Benjamin Leader and Carl A. Laskin -- 10. Task Force Report on Brain Involvement in Antiphospholipid Syndrome / Joab Chapman, Eyal Muscal and Robin L. Brey -- 11. Task Force Report on the Management of Thrombosis in Antiphospholipid Syndrome / Guillermo Ruiz-Irastorza, Vittorio Pengo, Maria G. Tektonidou, Ioana Ruiz-Arruza, María José Cuadrado, and Munther A. Khamashta -- 12. Task Force Report on Catastrophic Antiphospholipid Syndrome / Gerard Espinosa, Horacio Berman, Doruk Erkan and Ricard Cervera -- 13. Task Force Report on Non-criteria Manifestations: Thrombocytopenia / Gabriela Hernández-Molina, Xavier López-Karpovitch, Emilio B. González and Antonio R. Cabral -- 14. Task Force Report on Non-criteria Manifestations: Nephropathy / Maria G. Tektonidou, Horacio E. Adrogué and Smita Vaidya -- 15. Task Force Report on Non-criteria Manifestations: Cardiac Valve Disease / Gerard Espinosa, Lucía Fernández de Orueta, Elena Lluch, María Ángeles Polvorosa, Sandra Soro, and Ricard Cervera -- 16. Task Force Report on Non-criteria Manifestations: Skin / Michal Solomon, Yehuda Shoenfeld and Gisele Zandman-Goddard -- 17. Task Force Report on Antiphospholipid Syndrome Clinical Research / Doruk Erkan, Silvia S. Pierangeli and Michael D. Lockshin -- Part 4. Future of Antiphospholipid Syndrome -- 18. What are the Potential Future Treatments in Antiphospholipid Syndrome? / Doruk Erkan, Anisur Rahman, Hannah Cohen, Samuel J. Machin and Silvia S. Pierangeli -- 19. Remembrances of Predictions Past / Michael D. Lockshin -- Part 5. Antiphospholipid Syndrome for Patients -- 20. What Should Patients Know about Antiphospholipid Antibodies and Antiphospholipid Syndrome? / Doruk Erkan, Lindsay Lally and Michael D. Lockshin.
  • Death receptor signaling and its function in the immune system / Fas, S.C. ... [et al.] -- Inherited and acquired death receptor defects in human autoimmune lymphoproliferative syndrome / Rieux-Laucat, F. -- Tumor necrosis factor ligand-receptor superfamily and arthritis / Hsu, H.-C., Wu, Y., Mountz, J.D. -- Mitochondria, apoptosis and autoimmunity / Pinkoski, M.J., Waterhouse, N.J., Green, D.R. -- Role of Bim and other Bcl-2 family members in autoimmune and degenerative diseases / Hughes, P., Bouillet, P., Strasser, A. -- Mitochondria, cell death, and B cell tolerance / Deming, P.B., Rathmell, J.C. -- Role of complement and other innate immune mechanisms in the removal of apoptotic cells / Ogden, C.A., Elkon, K.B. -- Collectins: opsonins for apoptotic cells and regulators of inflammation / Stuart, L.M., Henson, P.M., Vandivier, R.W. -- MFG-E8-dependent clearance of apoptotic cells, and autoimmunity caused by its failure / Hanayama, R. ... [et al.] -- Clearance of apoptotic cells in human SLE / Gaipl, U.S. ... [et al.] -- Apoptosis and glomerulonephritis / Watson, S. ... [et al.].
  • History of immunology -- Molecules, cells, and tissues of the immune response -- Antigens and immunogens -- Major histocompatibility complex -- Antigen processing and presentation -- B lymphocyte development and immunoglobulin genes -- Immunoglobulin synthesis, properties, structure, and function -- Antigen-antibody interactions -- The thymus and T lymphocytes -- Cytokines and chemokines -- The complement system -- Types I, II, III, and IV hypersensitivity -- Immunoregulation and immunologic tolerance -- Autoimmunity -- Mucosal immunity -- Immunohematology -- Immunological diseases and immunopathology -- Immunophenotyping of hematopoietic malignancies -- Immunodeficiencies: congenital and acquired -- Acquired immune deficiency syndrome (AIDS) -- Immunomodulators -- Transplantation immunology -- Tumor immunology -- Immunity against microorganisms -- Vaccines and immunization -- Therapeutic immunology -- Comparative immunology -- Immunological methods and molecular techniques -- Diagnostic immunohistochemistry.
  • Atlas of Lymph Node Pathology reviews the histopathology of nodal diseases, illustrating the use of ancillary studies and includes concise discussions of pathogenesis, clinical settings and clinical significance of the pathologic diagnosis. The atlas features an overview of the benign reactive processes secondary to infectious, environmental or unknown insults, as well as relevant illustrations of virtually all primary and secondary neoplasms involving lymph nodes. The atlas also includes macroscopic images of some disorders, tables that help readers understand and comprehend diseases that look alike, and diagnostic algorithms for certain groups of diseases. Authored by highly experienced pathologists, Atlas of Lymph Node Pathology is a valuable resource that illustrates the vast majority of diseases practicing pathologists, clinicians and oncologists are likely to encounter in daily practice.
  • 1. Normal Morphologic and Immunohistochemical Findings and Hyperplasias -- 2. Congenital Malformations and Abnormalities of Spleen Location and Histology -- 3. Lmphoid Neoplasms -- 4. Myeloid and Related Disorders -- 5. Nonhematopoietic Lesions Including Vascular -- 6. Reactive and Systemic Conditions -- 7. Infections.
  • Atopic dermatitis is amongst the most common disorders of the skin in young people around the world. This book presents the newest insights and novel concepts in relation to all aspects of this skin disorder. Classification, clinical features and differential diagnosis are reviewed in the first chapter, while risk factors, susceptibility and an epidemiological overview are outlined in the next chapter, followed by a detailed discussion of the immunology of the skin and the pathophysiology of dermatitis. Further chapters present new data delineating clinical aspects of current genetic findings and insights into concepts of neuroimmunology, as well as the very crucial and severe clinical aspect of itching. New data on the topic of inhalant allergy, specific immunologic treatments and the latest on food allergy are also included.
  • Type, topography, and sequelae of neuropathological changes shaping clinical phenotype of autism / Jerzy Wegiel ... [et al.] -- Evidence for oxidative damage in the autistic brain / Teresa A. Evans ... [et al] -- Oxidative stress and neurotrophin signaling in autism / Elizabeth M. Sajdel-Sulkowska -- Genetics of autism / W. Ted Brown -- The phenotypic expression of autism, maternal depression, and the monoamine oxidase-a gene / Ira L. Cohen -- Paraoxonase 1 status, environmental exposures, and oxidative stress in autism spectrum disorders / Maria Dronca and Sergiu P. Pasca -- The redox/methylation hypothesis of autism : a molecular mechanism for heavy metal-induced neurotoxicity / Richard C. Deth -- Autism and oxidative stress : evidence from an animal model / Michelle A. Cheh ... [et al.] -- Neurotoxic brainstem impairment as proposed threshold event in autistic regression / Woody R. McGinnis ... [et al.] -- Abnormalities in membrane lipids, membrane-associated proteins, and signal transduction in autism / Ved Chauhan and Abha Chauhan -- Mitochondrial component of calcium signaling abnormality in autism / J. Jay Gargus -- Inflammation and neuroimmunity in the pathogenesis of autism : neural and immune network interactions / Carlos A. Pardo-Villamizar and Andrew W. Zimmerman -- Possible impact of innate immunity on autism / Harumi Jyonouchi -- Autism, gastrointestinal disturbance, and immune dysfunction : what is the link? / Paul Ashwood, Amanda Enstrom, and Judy van de Water -- Possible mechanism involving intestinal oxytocin, oxidative stress, and signaling pathways in a subset of autism with gut symptoms / Martha G. Welch and Benjamin Y. Klein -- Cytokine polymorphisms in autism : their role in immune alterations / Fabián Crespo ... [et al.] -- Autism, teratogenic alleles, HLA-DR4, and immune function / William G. Johnson ... [et al.] -- Autism : the centrality of active pathophysiology and the shift from static to chronic dynamic encephalopathy / Martha R. Herbert -- A re-evaluation of the state of autism treatment : the need for a biopsychosocial perspective / Eric London.
  • This book describes how the Jerne-Burnet Forbidden Clone Theory and the Adams-Knight H Gene Theory, solved the pathogenesis and genetics of the autoimmune diseases showing how specific immunotherapy and prophylaxis can be developed. Furthermore, Ebringer's discovery of two microbial triggers of autoimmune diseases is described and the conclusion drawn that all autoimmune diseases have microbial triggers, so will be preventable by the finding of the triggers and vaccination against them.
  • Assessment and Management of the Rheumatological Patient in the Critical Care Unit -- Life-Threatening Complications of Systemic Lupus Erythematosus -- Catastrophic Antiphospholipid Syndrome -- Complex Situations in Rheumatoid Arthritis -- Sjögren's Syndrome: Beyond Sicca Involvement -- Systemic Sclerosis: Severe Involvement of Internal Organs -- Vasculitic Emergencies in Patients with Large-Vessel Vasculitis -- Life-Threatening Presentations of ANCA-Associated Vasculitis -- Severe Polyarteritis Nodosa -- Life-Threatening Cryoglobulinemia -- Behçets Syndrome: Clinical Presentations Affecting Prognosis and Survival -- Myositis: When Weakness Can Kill -- Complicated Sarcoidosis: Challenges in Dealing with Severe Manifestations -- Complex Situations in Patients with Adult-Onset Still's Disease -- Managing Acute and Complex Dermatological Situations -- Life-Threatening Autoimmune Hematological Disorders -- Autoimmune Ear, Nose, and Throat Emergencies -- Ophthalmological Emergencies in Rheumatic and Autoimmune Diseases -- Emergencies for the Vascular Surgeon -- Complicated Pregnancies in Patients with Autoimmune Systemic Diseases -- The Complex Management of Viral-Related Autoimmune Diseases -- The Role of Intravenous Immunoglobulins in the Management of Acute Complex Autoimmune Conditions -- Life-Threatening Complications of Biological Therapies.
  • Pathogenesis of autoimmune diseases / Martin Röcken and Tilo Biedermann -- Autoantibody detection using indirect immunofluorescence on HEp-2 cells / Philipp von Landenberg -- Pemphigus / Michael Hertl and Rüdiger Eming -- Bullous pemphigoid : clinical features, diagnostic markers, and immunopathogenic mechanisms / Giovanni Di Zenzo ... [et al.] -- Dermatitis herpetiformis duhring / Christian Rose and Detlef Zillikens -- Epidermolysis bullosa acquisita / Gene Kim ... [et al.] -- Localized scleroderma / Cristián Vera Kellet, Catherine H. Orteu, and Jan P. Dutz -- Progressive systemic scleroderm / Nicolas Hunzelmann and Thomas Krieg -- Chronic cutaneous lupus erythematosus / Michael Sticherling -- Subacute cutaneous and systemic lupus erythematosus / Donna M. Pellowski, Jane E. Kihslinger, and Richard D. Sontheimer -- Dermatomyositis / Ruth Ann Vleugels and Jeffrey P. Callen -- Mixed connective tissue disease / Reiji Kasukawa -- Sjögren's Syndrome / Robert I. Fox and Carla M. Fox -- Psoriasis vulgaris and arthopathica / Arnd Jacobi and Jörg Christoph Prinz -- Chronic urticaria as an autoimmune disease / Clive Grattan, Michihiro Hide, and Malcolm W. Greaves -- Lichen planus, lichenoid eruptions and cutaneous grant-versus-host-reaction / Miklós Simon, Jr. -- Small vessel vasculitides / Peter Lamprecht and Wolfgang L. Gross -- Skin manifestations of rheumatic diseases / Camille Francés and Nicolas Kluger -- Vitiligo / Karin U. Schallreuter -- Alopecia areata / Pia Freyschmidt-Paul, Kevin McElwee, and Rolf Hoffmann -- Autoimmune phenomena in atopic dermatitis / Caroline Bussmann and Natalija Novak -- Eosinophils in autoimmune bullous diseases / Dagmar Simon and Hans-Uwe Simon -- Paraneoplastic syndromes of the skin / Peter Fritsch -- Targeted therapies in autoimmune and inflammatory skin disorders / Rüdiger Eming and Ingo H. Tarner.
  • 2014 ClinicalKey
  • Autoimmune Liver Diseases summarizes the recent high-impact research and clinical findings obtained in Japan in the study and treatment of autoimmune liver diseases. Although these disorders are relatively rare, they are recognized as an important group of refractory liver diseases, the most common of which are autoimmune hepatitis (AIH) and primary biliary cirrhosis (PBC). The book therefore comprises two major sections, one dealing with AIH, the other with PBC. AIH in Japanese patients creates a unique disease population, as its clinical features are different from those of Western patients resulting from the different genetic background of the two patient populations. Also, mouse models of neonatal thymectomy-PD-1 knockout mice, clinical analyses of acute hepatitis-like manifestations, and research findings on IgG4-related autoimmune hepatitis have been reported in Japan and are included in this book. A disease-susceptibility gene specific to Japanese PBC patients has also recently been discovered. Because of the relatively homogeneous population of Japan, analyses conducted with Japanese PBC patients have yielded findings that are highly relevant to the pathogenesis of the disease. Furthermore, new pathological staging criteria, anti-gp210 antibodies and the basis they provide for improved accuracy of prognosis, treatment with bezafibrate, and the outcomes of living-donor liver transplantation are also presented here. This volume therefore serves as a useful resource not only for hepatologists, but also for researchers, clinical residents, and medical students both in Japan and in other countries.
  • This book provides up-to-date information on all aspects of autoimmune pancreatitis, a unique form of pancreatitis characterized clinically by frequent presentation with obstructive jaundice and dramatic response to steroids, histologically by a lymphoplasmacytic infiltrate with fibrosis, and radiologically by pancreatic enlargement. Current concepts regarding the disease and its classification into subtypes 1 and 2 are explained, and clinical, serological, and histopathological findings are carefully described. Imaging features on all the relevant modalities are illustrated, covering both the pancreas and other involved organs. Current and emerging therapeutic strategies, including steroids, immunomodulatory drugs, and rituximab, are then discussed. The reader will find the book to be an excellent aid to the diagnosis of autoimmune pancreatitis and its differentiation from pancreatobiliary malignancies, as well as a clear guide to treatment.
  • Autophagosome and phagosome 2008
    Springer Protocols
    Autophagosome and phagosome / V. Deretic -- Fine structure of the autophagosome / E.L. Eskelinen -- Methods for assessing autophagy and autophagic cell death / E. Tasdemir ... [et al.] -- LC3 and Autophagy / I. Tanida, T. Ueno and E. Kominami -- Amino Acid regulation of autophagosome formation / A.J. Meijer -- Autophagic proteolysis of long-lived proteins in nonliver cells / E.A. Roberts and V. Deretic -- Autophagosomes in GFP-LC3 Transgenic Mice / N. Mizushima and A. Kuma -- Experimental control and characterization of autophagy in Drosophila / G. Juhasz and T.P. Neufeld -- Analysis of autophagosome membrane cycling by fluorescence microscopy / J.E. Legakis and D.J. Klionsky -- Protein trafficking into autophagosomes / A. Young and S. Tooze -- Sphingolipids in macroautophagy / G. Lavieu ... [et al.] -- Molecular links between autophagy and apoptosis / I.A. Ciechomska, C.G. Goemans and A.M. Tolkovsky -- Clearance of mutant aggregate-prone proteins by autophagy / B. Ravikumar, S. Sarkar and D.C. Rubinsztein -- Localization and MHC Class II Presentation of Antigens Targeted for Macroautophagy / D. Schmid and C. Munz -- Chaperone-mediated autophagy / S. Kaushik and A.M. Cuervo -- Microautophagy in the Yeast Saccharomyces cerevisiae / A. Uttenweiler and A. Mayer -- EM Analysis of Phagosomes / C. de Chastellier -- Analysis of phosphoinositide dynamics during phagocytosis using genetically encoded fluorescent biosensors / G. Cosio and S. Grinstein -- In vitro phagosome-endosome fusion / I. Vergne and V. Deretic -- Real-time spectrofluorometric assays for the lumenal environment of the maturing phagosome / R.M. Yates and D.G. Russell -- Maturation changes in purified phagosomes / R. Dieckmann ... [et al.] -- Large-scale purification of latex bead phagosomes from mouse macrophage cell lines and subsequent preparation for high-throughput quantitative proteomics / A. Rupper and J. Cardelli -- Class II MHC Antigen Processing in Phagosomes / L. Ramachandra, W.H. Boom and C.V. Harding -- Analyzing Association of the Endoplasmic Reticulum with the Legionella pneumophila-Containing Vacuoles by Fluorescence Microscopy / A. Ingmundson and C.R. Roy -- Fractionation of the Coxiella burnetii Parasitophorous Vacuole / D. Howe and R.A. Heinzen -- Bacterial Phagosome Acidification Within IFN-gamma-Activated Macrophages: Role of Host p47 Immunity-Related GTPases (IRGs) / S. Tiwari and J.D. Macmicking -- SopE-Mediated Recruitment of Host Rab5 on Phagosomes Inhibits Salmonella Transport to Lysosomes / R. Madan, G. Krishnamurthy and A. Mukhopadhyay -- The Mycobacterium tuberculosis Phagosome / E.A. Roberts and V. Deretic.
  • v. 2, 2014 ScienceDirect
    v.3, 2014 ScienceDirect
    Volume 1. Molecular mechanisms -- Volume 2. Role in general diseases -- Volume 3. Mitophagy.
  • Avian immunology. 2nd ed. 2014
    Provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, this book encompasses all aspects of innate and adaptive immunity in chickens.
  • Determinations of B cell fate in immunity and autoimmunity / Noelle, R.J.; Erickson, L.D. -- Regulatory roles for cytokine-producing B cells in infection and autoimmune disease / Lund, F.E. ... [et al.] -- The CD19-CD21 signal transduction complex of B lymphocytes regulates the balance between health and autoimmune disease / Tedder, T.F. ... [et al.] -- Marginal zone B cell physiology and disease / Lopes-Carvalho, T.; Kearney, J.F. -- Dendritic cells control B cell growth and differentiation / Jego, G. ... [et al.] -- The biology of CD20 and its potential as a target for mAb therapy / Cragg, M.S. ... [et al.] -- B lymphocyte depletion in rheumatoid arthritis / Edwards, J.C.W.; Leandro, M.J.; Cambridge, G. -- Treatment of SLE with anti-CD20 monoclonal antibody / Looney, R.J.; Anolik, J.; Sanz, I. -- The biochemistry and biology of BAFF, APRIL and their receptors / Kalled, S.L.; Ambrose, C.; Hsu, Y.-M. -- The BAFF/APRIL system / Mackay, F. ... [et al.] -- Human B lymphocyte malignancies / Jelinek, D.F.; Darce, J.R. -- BlySfulness does not equal blissfulness in systemic lupus erythematosus / Stohl, W.
  • Anatomy and cells of the immune system -- Innate immunity I: physical and humoral protection -- Innate immunology II: cellular mechanisms -- Acquired immunity: antigen receptors -- The human leukocyte antigens -- Cellular immune responses I: dendritic cells, macrophages and B lymphocytes -- Cellular immune responses II: T lymphocytes, antigen presentation and natural killer cells -- The immune response to microbes: an overview -- Tolerance and mechanisms of autoimmunity -- Hypersensitivity reactions and clinical allergy -- Transplantation -- Rheumatic diseases -- Endocrine autoimmune disease -- Liver diseases -- Gastrointestinal diseases -- Immune-mediated nephritis and vasculitis -- Immune-mediated skin disease -- Immune-mediated diseases of the nervous system and eye -- Immunodificiency -- Human immunodeficiency virus and AIDS -- Immunological manifestations of haematological disease -- Immune-based therapies -- Immunisation.
  • Introduction to the immune system : nomenclature, general properties, and components -- Innate immunity : the early defense against infections -- Antigen capture and presentation to lymphocytes : what lymphocytes see -- Antigen recognition in the adaptive immune system : structure of lymphocyte antigen receptors and development of immune repertoires -- T cell-mediated immunity : activation of t lymphocytes by cell-associated antigens -- Effector mechanisms of t cell-mediated immunity : functions of t cells in host defense -- Humoral immune responses : activation of b lymphocytes and production of antibodies -- Effector mechanisms of humoral immunity : elimination of extracellular microbes and toxins -- Immunological tolerance and autoimmunity : self-nonself discrimination in the immune system and its failure -- Immune responses against tumors and transplants : immunity to noninfectious transformed and foreign cells -- Hypersensitivity : disorders caused by immune responses -- Congenital and acquired immunodeficiencies : diseases caused by defective immunity.
  • This book, besides reviewing basic and clinical aspects of Behėt's disease, covers the latest findings, including genetic studies and treatment with biologics for the disease. Although the cause of Behėt's disease is still unknown, it is well known that genetic factors, such as HLA-B51, are involved in its development. Recently, novel susceptibility loci including IL10, IL23R-IL12RB2, and endoplasmic reticulum aminopeptidase 1 have been identified, providing new insights into the pathogenesis of the disease. In addition to basic research, the beneficial efficacy of anti-TNF-alpha monoclonal antibodies has also been suggested for not only uveitis associated with the disease but also other subtypes of the disease such as entero-, vasculo-, and neuro- Behėt's disease. Behėt's Disease: From Genetics to Therapies provides essential information both for basic researchers working in the fields of immunology, inflammation, and genetics, and for clinical physicians who are interested in Behėt's disease, such as ophthalmologists, rheumatologists, dermatologists, gastroenterologists, neurologists, and vascular surgeons.
  • 1. The Numbers of Behçet: A Rare Disease? / Agata Polizzi and Domenica Taruscio -- 2. From Hippocrates to Hulusi Behçet: What History / Donatella Lippi -- 3. Epidemiology of Behçet Syndrome / Olga Addimanda, Giulia Pazzola, Nicolò Pipitone and Carlo Salvarani -- 4. Behçet's Syndrome According to Classical and Population Genetics / Akira Meguro, Nobuhisa Mizuki, Ahmet Gül, Nobuyoshi Kitaichi and Shigeaki Ohno -- 5. Infections, Autoimmunity, and Behçet's Syndrome: What Liaison? / Mario Milco D'Elios, Marisa Benagiano, Amedeo Amedei and Giacomo Emmi -- 6. Pathogenesis of Behçet Syndrome / Giacomo Emmi, Danilo Squatrito, Elena Silvestri, Alessia Grassi and Lorenzo Emmi -- 7. Mucocutaneous Involvement in Behçet's Syndrome / Umit Tursen -- 8. Neurological and Neuropsychological Manifestation in Behçet's Syndrome / Shunsei Hirohata -- 9. Ocular Involvement and Behçet Disease / Lorenzo Vannozzi, Ugo Menchini and Massimo Accorinti -- 10. Articular and Muscular Manifestations in Behçet's Disease / Anne-Claire Desbois, Betrand Wechsler and David Saadoun -- 11. Cardiovascular Issues: Aneurysms and Pseudoaneurysms, Thrombosis, Atherosclerosis, and Cardiac Involvement / Elena Silvestri, Caterina Cenci, Chiara Della Bella, Anna Maria Cameli and Domenico Prisco -- 12. Intestinal Behçet Disease / Cristina Cenci and Monica Milla -- 13. Audio Vestibular Involvement in Behçet's Disease / Paolo Vannucchi and Rudi Pecci -- 14. Behçet's Syndrome and Gynecological Manifestation in Reproductive Age and Pregnancy / Maria Elisabetta Coccia and Tommaso Capezzuoli -- 15. Pediatric Onset of Behçet Syndrome / Ezgi Deniz Batu, Rolando Cimaz and Seza Özen -- 16. Behçet's Disease. Differential Diagnosis / Maria Grazia Sabbadini and Stefano Franchini -- 17. Classification and Diagnosis Criteria for Behçet's Disease / Fereydoun Davatchi, Bahar Sadeghi Abdollahi, Farhad Shahram, Cheyda Chams-Davatchi, Hormoz Shams and Abdolhadi Nadji -- 18. Prognosis and Disease Activity / Rosaria Talarico, Anna d'Ascanio, Rossella Neri, Chiara Baldini, Marta Mosca and Stefano Bombardieri -- 19. Old and New Treatment for Behçet's Disease / Fabrizio Cantini and Gerardo Di Scala -- 20. Surgical Treatment of Angio-Behçet / Stefano Camparini and Genadi Genadiev.
  • E. coli as an All-Rounder: The Thin Line Between Commensalism and Pathogenicity / Andreas Leimbach, Jörg Hacker, Ulrich Dobrindt -- What Distinguishes Highly Pathogenic Staphylococci from Medium- and Non-pathogenic? / Ralf Rosenstein, Friedrich Götz -- Microevolution of Pseudomonas aeruginosa to a Chronic Pathogen of the Cystic Fibrosis Lung / Michael Hogardt, Jürgen Heesemann -- Lactobacillus: Host-Microbe Relationships / John O'Callaghan, Paul W. O'Toole -- Bacterial Moonlighting Proteins and Bacterial Virulence / Brian Henderson, Andrew Martin -- Symbionts and Pathogens: What is the Difference? / Vicente Pérez-Brocal, Amparo Latorre, Andrés Moya -- Ecology and Physiology of the Intestinal Tract / Michael Blaut -- The Gut Microflora and Its Variety of Roles in Health and Disease / Julia-Stefanie Frick, Ingo B. Autenrieth -- Host-Recognition of Pathogens and Commensals in the Mammalian Intestine / Oriana Rossi, Peter van Baarlen, Jerry M. Wells -- Contribution of the Intestinal Microbiota to Human Health: From Birth to 100 Years of Age / Jing Cheng, Airi M. Palva, Willem M. de Vos.
  • Biological DNA Sensor defines the meaning of DNA sensing pathways and demonstrates the importance of the innate immune responses induced by double stranded DNA (dsDNA) through its influencing functions in disease pathology and immune activity of adjuvants for vaccines. Though discussed in specific subsections of existing books, dsDNA and its immunogenic properties has never received the complete treatment given in this book. Biological DNA Sensor approaches the impact of dsDNA's immunogenicity on disease and vaccinology holistically. It paints a complete and concise picture on the topic so you can understand this area of study and make more informed choices for your respective research needs. Chapters are authored by researchers who are renowned for their research focus, ensuring that this book provides the most complete views on the topics. Multi-authored by a distinguished panel of world-class expertsIdeal source of information for those wanting to learn about DNA sensingProvides in-depth explanations of DNA sensing pathways and the innate immune system, bridging the gap between them
  • "The concept of using bispecific antibodies for cancer therapy by retargeting immune effector cells was developed more than 25 years ago. However, initial clinical studies were rather disappointing mainly due to low efficacy, severe side effects and the immunogenicity of the bispecific antibodies. A deeper understanding of effector cell biology and especially developments in the field of antibody engineering has led to the generation of new classes of bispecific antibodies capable of circumventing many of these obstacles. Furthermore, new applications were established for bispecific antibodies, such as pre-targeting strategies in radioimmunotherapy and dual targeting approaches in order to improve binding, selectivity and efficacy. In this book, the different means of generating bispecific antibodies are described, with an emphasis on recombinant formats, and information on the various applications of bispecific antibodies, e.g. in cellular cancer immunotherapy, radioimmunotherapy and pretargeting strategies, but also on emerging applications such as dual targeting strategies, i.e., the simultaneous inhibition of two targets (cytokines, receptors, etc.) are provided. This book is intended for a broad readership in the field of antibody engineering, mainly from the pharmaceutical and biotechnology sector, but also including academic researchers working in this field."--Publisher's website.
  • The extremely potent substance botulinum neurotoxin (BoNT) has attracted much interest in diverse fields. Originally identified as cause for the rare but deadly disease botulism, military and terrorist intended to misuse this sophisticated molecule as biological weapon. This caused its classification as select agent category A by the Centers for Diseases Control and Prevention and the listing in the Biological and Toxin Weapons Convention. Later, the civilian use of BoNT as long acting peripheral muscle relaxant has turned this molecule into an indispensable pharmaceutical world wide with annual revenues >$1.5 billion.
  • The Cytokine System -- The Discovery of the Brain Immunomodulators -- Brain Neuroendocrine Immune System: Neurosecretion of Interleukins and New Cytokines Produced by NSO and NPV of Hypothalamus -- Antibacterial and Antiviral Activity of PRP-1 (Galarmin) and Some Immunological Mechanisms of its Action -- Treatment and Prophylaxis of Anthrax by Galarmin: Receptor Tyrosine Kinases is a Target of Galarmin -- Prophylaxis and Treatment of Methicillin-Resistant Staphylococcus Aureus (MRSA) Infection with Proline-Rich Polypeptides Galarmin and Its Structural Analogues in an Experimental Murine Model -- Treatment of Clostridium Perfringens-induced Gas Gangrene by New Cytokines of Brain -- Hypothalamic, Proline-Rich Polypeptide (Galarmin) has Protective and Immunogenic Activity on Experimental Mycobacterium Tuberculosis Infection -- Brain-Bone Marrow Neurohumoral Axis: Galarmin Controls Differentiation, Proliferation and Mobilization of Bone Marrow Progenitor cells -- Antioxidant-Antiradical and Electron Donating Function of Galarmin and Gx-NH2 -- Discussion -- Summary.
  • Immune infiltration in human cancer : prognostic significance and disease control / Wolf H. Fridman ... [et al.] -- Subversion and coercion : the art of redirecting tumor immune surveillance / John B. Mumm and Martin Oft -- STAT3 : a target to enhance antitumor immune response / Heehyoung Lee ... [et al.] -- Biology and clinical observations of regulatory T cells in cancer immunology / Michele W. Teng ... [et al.] -- Concepts and ways to amplify the antitumor immune response / Bent Rubin and Jean Edouard Gairin -- Angiogenesis and the tumor vasculature as antitumor immune modulators : the role of vascular endothelial growth factor and endothelin / Lana E. Kandalaft ... [et al.] -- Adoptive cellular therapy / Stephen A. Grupp and Carl H. June -- Dendritic cell subsets as vectors and targets for improved cancer therapy / Karolina Palucka ... [et al.] -- Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.] -- Modulation of CTLA-4 and GITR for Cancer Immunotherapy / Francesca Avogadri ... [et al.] -- Immunobiology of cancer therapies targeting CD137 and B7-H1/PD-1 cosignal pathways / Shengdian Wang and Lieping Chen -- LAG-3 in cancer immunotherapy / Monica V. Goldberg and Charles G. Drake -- Immunologically active biomaterials for cancer therapy / Omar A. Ali and David J. Mooney -- Erratum : Identification of human idiotype-specific T cells in lymphoma and myeloma / Jinsheng Weng ... [et al.].
  • Specific Organ Tumors: General Considerations On Immunotherapy -- Vaccination Of Human Solid Tumors: Recent Progress In The Clinical Setting -- Immunotherapy For Pediatric Solid Tumors -- Immunopathology Of Hematological Cancers And Immunotherapy Of Leukemia And Multiple Myeloma -- Immunopathology Of Lymphoma And Immunotherapy Of Hodgkin's Disease And Non-Hodgkin's Lymphoma -- Cancer-Testis Antigens As Targets For The Immunotherapy Of Hematological Malignancies -- Tumor Immunology And Immunotherapy Of Gastrointestinal Tract Cancers -- Immunology And Immunotherapy Of Colorectal Cancer -- Immunopathology Of Hepatobiliary Tumors And Immunotherapy Of Liver Cancers -- Immunology And Immunotherapy Of Pancreatic Tumors -- Immunology Of Cutaneous Tumors And Immunotherapy For Melanoma -- Immunopathology Of Head And Neck Tumors And Immunotherapy Of Squamous Cell Carcinoma -- Immunopathology And Immunotherapy Of Oral Cancers -- Immunopathology Of Bone And Connective Tissue Cancers And Immunotherapy Of Sarcomas -- Immunopathology Of Central Nervous System Cancers And Immunotherapy Of Brain Tumors -- Immunology And Immunotherapy Of Pulmonary Tumors -- Immunopathology Of Urinary System Cancers And Immunotherapy Of Renal And Bladder Cancers -- Immunopathology Of Cancers Of Male And Female Genitalia Organs And Immunotherapy Of Cervical And Prostate Cancer -- Immunology And Immunotherapy Of Ovarian Cancer -- Revisiting Immunology For Breast Cancer -- Immunology And Immunotherapy Of Graft Versus Host Disease.
  • Cancer Immunology is intended as an up-to-date, clinically relevant review of cancer immunology and immunotherapy. The rapid flow of studies in the field of cancer immunology during the last decade has increased our understanding of the interactions between the immune system and cancerous cells. In particular, it is now well known that such interactions result in the induction of epigenetic changes in cancerous cells and the selection of less immunogenic clones as well as alterations in immune responses. Understanding the cross-talk between nascent transformed cells and cells of the immune system has led to the development of combinatorial immunotherapeutic strategies to combat cancer. This volume is focused on interactions between cancerous cells and various components of the innate and adaptive immune system are fully described. Notably, the principal focus is very much on clinical aspects, the aim being to educate clinicians on the clinical implications of the most recent findings and novel developments in the field. This is to be hoped that this translational book will be comprehensible, cogent and of special value for researchers and clinicians who wish to extend their knowledge on cancer immunology.
  • This translational book describes in detail the clinical application of novel approaches in cancer immunotherapy with the aim of educating clinicians in the implications of the most recent research and new developments in the field. The scope is broad, encompassing, for example, prognostic biomarkers for personalized cancer treatment, strategies for targeting tumor immunosuppression, gene therapy, virus-based vaccines, targeting of cancer stem cells, hematopoietic stem cell transplantation, the role of T lymphocytes in cancer immunotherapy, use of monoclonal antibodies, and many more innovative approaches. Clinical immunologists, hematologists, and oncologists in particular will find the book to be of value in expanding their knowledge. ℗ℓ The book is the second in a three-volume series, Cancer Immunology, which offers an up-to-date review of cancer immunology and immunotherapy. The remaining volumes focus on the immunopathology of cancers and cancer immunotherapy for organ-specific tumors. In total the series, designed for both clinicians and researchers, includes contributions from more than 250 scientists working at leading universities and institutes from across the world.
  • This book provides a comprehensive update on the state of the art in cancer immunology, which has rapidly evolved from a field of clinical research into an established discipline of oncology. The key recent developments in immuno-oncology are all covered, from the ever-changing immunological and regulatory frameworks to the most promising therapeutic concepts. Themes include combination therapies and personalized medicine, as well as identification of biomarkers to guide the clinical development of new approaches and to pinpoint the optimal treatment for each patient. The book acknowledges the continuing dynamic nature of the field as reflected in the development of next-generation immunotherapies that are already in clinical testing. Cancer Immunotherapy Meets Oncology is dedicated to the lifetime achievements of Christoph Huber, founder and chair of the Association for Cancer Immunotherapy (CIMT). It is also a tribute to those researchers and clinicians who are striving to develop novel diagnostics and tailored immunotherapies for the benefit of cancer patients.
  • Popular for its highly visual, straightforward approach, Cellular and Molecular Immunology delivers an accessible yet thorough understanding of this active and fast-changing field. Drs. Abul K. Abbas, Andrew H. Lichtman, and Shiv Pillai present key updates in this new edition to cover the latest developments in antigen receptors and signal transduction in immune cells, mucosal and skin immunity, cytokines, leukocyte-endothelial interaction, and more.
  • The Anthrax Capsule: Role in Pathogenesis and Target for Vaccines and Therapeutics / Arthur M. Friedlander -- Proteomic Studies of Bacillus anthracis Reveal In Vitro CO2-Modulation and Expression During Infection of Extracellular Proteases / Theodor Chitlaru, Orit Gat, Galia Zaide, Haim Grosfeld and Izhak Inbar, et al. -- Dynamics of Bacillus anthracis Infection and Control Mechanisms / Pierre L. Goossens, Ian J. Glomski, Lhousseine Touqui and Michèle Mock -- Survival and Trafficking of Yersinia pestis in Non-acidified Phagosomes in Murine Macrophages / James B. Bliska -- The Inverse Relationship Between Cytotoxicity of Y. pestis and Its Virulence / Emanuelle Mamroud, Avital Tidhar, Yinon Levy, Erez Bar-Haim and Gideon Halperin, et al. -- The NlpD Lipoprotein of Yersinia pestis is Essential for Cell Separation and Virulence / Avital Tidhar, Yehuda Flashner, Sara Cohen, Yinon Levy and Ayelet Zauberman, et al. -- Dissection of the Functions of the IglC Protein of Francisella tularensis / Jeanette E. Bröms, Moa Lavander and Anders Sjöstedt -- Yersinia pestis Lipopolysaccharide in Host-Pathogen Interactions / Andrey P. Anisimov, Svetlana V. Dentovskaya, Anna N. Kondakova, Buko Lindner and Rima Z. Shaikhutdinova, et al. -- The Interactions Between Pathogens and Dendritic Cells: From Paralysis of Cells to Their Recruitment for Bacterial Colonization / Baruch Velan, Erez Bar-Haim, Gal Markel, Hila Cohen and Ayelet Zauberman, et al. -- Comparative Approaches to Identify Host Factors Specifically Targeted by Yersinia pestis During the Infectious Process / Françoise Guinet, Patrick Avé, Louis Jones, Michel Huerre and Elisabeth Carniel -- Poxvirus Entry into Host Cells / Bernard Moss, Zain Bengali, Himani Bisht, Jason P. Laliberte and P.S. Satheskumar -- Role of A33R Amino-Acid 118L in the Interactions of Vaccinia Virus with the Host / Nir Paran, Shlomo Lustig, Anat Zvi, Tomer Israely and Sharon Melamed, et al. -- Inhibitors of Innate Immunity from Vaccinia Virus / Geoffrey L. Smith -- Brucella Species Synchronize Their Life Cycle to the Gestation Cycle of Their Ruminant Hosts / Svetlana Bardenstein and Menachem Banai -- MMP-9 as a Marker for Vaccinia Virus Related Encephalitis / Tomer Israely, Sharon Melamed, Noam Erez, Boaz Politi and Udy Olshevsky, et al. -- Epidemic Cowpox Virus Infections in Germany / Andreas Kurth and Andreas Nitsche -- The Two Partner Secretion Transporters of Yersinia pestis: Cloning, Immunogenicity and In Vivo Expression Following Airway Infection / Yinon Levy, Anat Zvi, Haim Grosfeld, Avital Tidhar and David Gur, et al. -- Genetic Detection of Vesicle Forming Pathogens by Arrayed Primer Extension (APEX) / Adi Beth-Din, Ofir Israeli, Ohad Shifman, Dana Stein and Einat Ben-Arie, et al. -- Subtyping Biothreat Bacterial Pathogens / Paul Keim and Talima Pearson -- A Rapid Method for Bacillus anthracis Genotyping / Haim Levy, Morly Fisher, Naomi Ariel, Shay Weiss and Anat Zvi, et al. -- Tularemia - A Disease with an Uncertain Impact on Public Health / Roland Grunow, Daniela Jacob, Andrea Kühn and Herbert Nattermann -- Consequences of Antibiotic Treatment of Francisella tularensis Airways Infections / Erez Bar-Haim, Hila Cohen, Raphael Ber, Ofer Cohen and Avigdor Shafferman -- Novel Live Vaccine Candidates Against Airborne Francisella tularensis / Wayne Conlan and Anders Sjöstedt -- Effect of Disruption of mglA on the Virulence and Immunogenicity of the Francisella tularensis Live Vaccine Strain (LVS) / Ofer Cohen, Galia Zaide, Erez Bar-Haim, Itai Mendelson and Orit Gat, et al. -- Data Mining, Bioinformatic and Immunoinformatic Analyses of Francisella tularensis Schu S4 Genome in Search for Novel Vaccine Candidates / Anat Zvi, Naomi Ariel and Avigdor Shafferman -- Modified Vaccinia Virus Ankara (MVA) based Vaccines - Immunostimulatory and Protective Capacity / Michael H. Lehmann, Melanie Kremer, Yasemin Suezer and Gerd Sutter -- Therapeutic Potential of Vaccinia Hyper Immune Sera in Mouse Models of Lethal Orthopoxviruses Infection / Sharon Melamed, Nir Paran, Tomer Israely, Noam Erez and Shaul Reuveny, et al. -- A Live Plaque Vaccine Candidate with Improved Safety and Immunogenecity / V.A. Feodorova, L.N. Pan'kina, E.P. Savostina, O.S. Kuznetsov and N.P. Konnov, et al. -- Protection Against Plague Afforded by Treatment with Polyclonal αLcrV and αF1 Antibodies / Yinon Levy, Yehuda Flashner, Ayelet Zauberman, Avital Tidhar and Moshe Aftalion, et al. -- Combination of Anthrax-Toxin Neutralizing Antibodies: Analysis of Synergism/Antagonism Effect / Ohad Mazor, Einat Ben-Arie, Adva Mechaly, Ronit Rosenfeld and Hadar Marcus, et al. -- The Efficacy of Antibiotic Treatment to Cure Guinea Pigs Intranasally Infected with Bacillus anthracis Spores / Zeev Altboum, Haim Levy, Shay Weiss, Avi Pass and Nili Rothschild, et al. -- Reverse Vaccinology in Bacillus anthracis / Avigdor Shafferman, Orit Gat, Naomi Ariel, Theodor Chitlaru and Haim Grosfeld, et al.
  • pt. 1. Urticaria and angiodema -- pt. 2. Skin manifestation of drug allergy -- pt. 3. Allergic contact dermatitis -- pt. 4. Other allergies affecting skin and mucous membranes -- pt. 5. Immunologic diseases of the skin.
  • Rhinitis -- Chronic rhinosinusitis -- Allergic diseases of the eye -- Urticaria and angioedema -- Allergic contact dermatitis -- Hypersensitivity pneumonitis -- Atopic dermatitis -- Food allergy -- Drug allergy -- Anaphylaxis -- Eosinophilia and eosinophilic disorder -- Occupational asthma -- Asthma conundrums -- Mastocytosis -- Allergic bronchopulmonary aspergillosis -- HIV/AIDS and complications -- Disorders of immune regulation -- Autoimmune diseases -- Immune-mediated rheumatic diseases -- Immunodeficiency.
  • Part I. Introduction.-- Chemokine system in experimental and clinical hematology / Oystein Bruserud, Astrid Olsnes Kittang.-- Part II. Experimental hematology.-- Chemokine decoy receptors: strucuture-function and biological properties / Raffaella Bonecchi, Benedetta Savino, Elena M. Borroni, Alberto Mantovani, Massimo Locati.-- Role of chemokines in the biology of natural killer cells / Azzram A. Maghazachi.-- Chemokines in angiogenesis / Anna Dimbert.-- Part III. Immunobiology of allogeneic stem cell transplantation.-- Genetic polymorphisms in the cytokine and chemokine systems: their possible importance in allogeneic stem cell transplantation / Jeurgen Loeffler, Michael Ok, Oliver C. Morton, Markus Mezger, Hermann Einsele.-- Chemokine system: a possible therapeutic target in acute graft versus host disease / Nicolai A. Kittan, Gerhard C. Hildebrandt.-- Homing in on acute graft vs. host disease: tissue-specific T regulatory and Th17 cells / Brian G. Engelhardt, James E. Crowe Jr.-- Part IV: Clinical hematology.-- Chemokine network in acute myelogenous leukemia: molecular mechanisms involved in leukemogenesis and therapeutic implications / Astrid Olsnes Kittang, Kimberley Hatfield, Kristoffer Sand, Hakon Reikvam, Oystein Bruserud.-- CXCR4 in clinical hematology / Gary Calandra, Gary Bridger, Simon Fricker.-- Immunobiology of herparin-induced thrombocytopenia / Per Morten Sandset.
  • Functional diversity of chemokines and chemokine receptors in response to viral infection of the central nervous system / T.E. Lane, J.L. Hardison, and K.B. Walsh -- Cytokine and chemokine networks : pathways to antiviral defense / T.P. Salazar-Mather and K.L. Hokeness -- Herpes simplex virus and the chemokines that mediate the inflammation / D.J.J. Carr and L. Tomanek -- Influence of proinflammatory cytokines and chemokines on the neuropathogenesis of oncornavirus and immunosuppressive lentivirus infections / K.E. Peterson and B. Chesebro -- HIV-1 coreceptors and their inhibitors / N. Ray and R.W. Doms -- A viral conspiracy : hijacking the chemokine system through virally encoded pirated chemokine receptors / H.F. Vischer, C. Vink, and M.J. Smit.
  • Section I. Systems Biology of Inflammation and Regulatory Mechanisms -- Chapter 1. At the Interface between Acute and Chronic Inflammation / Yoram Vodovotz -- Chapter 2. The Cellular Component of Chronic Inflammation / Julie M. Roda, Tim D. Eubank -- Chapter 3. Mast Cells in Chronic Inflammation / Traci A. Wilgus, Brian C. Wulff -- Chapter 4. Hypoxia and Hypoxia-Inducible Factor in Inflammation / Kiichi Hirota -- Chapter 5. Bioactive Phospholipid Mediators of Inflammation / Sainath R. Kotha, Jordan D. Secor, Smitha Malireddy, Gowrishankar Gnanasekaran, Narasimham L. Parinandi -- Chapter 6. Hematopoietic Stem Cells in Atherosclerotic Development and Resolution / Reeva Aggarwal, Vincent J. Pompili, Hiranmoy Das -- Chapter 7. Inflammation as a Confounding Factor in Regenerative Medicine / Myron Allukian, Kenneth W. Liechty -- Chapter 8. NOX in the CNS / Annadora J. Bruce-Keller -- Chapter 9. Resolution of Inflammation / Amitava Das, Sashwati Roy -- Chapter 10. H2S in Inflammation / Hyun-Ock Pae, Hun-Taeg Chung -- Section II. Pathologies Associated with Inflammation -- Chapter 11. Is There a Connection between Inflammation and Oxidative Stress? / Chandrakala Aluganti Narasimhulu, Xueting Jiang, Zhaohui Yang, Krithika Selvarajan, Sampath Parthasarathy -- Chapter 12. Chronic Inflammation and Cancer / Subash C. Gupta, Ji Hye Kim, Sahdeo Prasad, Bharat B. Aggarwal -- Chapter 13. Chronic Wounds and Inflammation / Jaideep Banerjee, Chandan K. Sen -- Chapter 14. Multiphasic Roles for TGF-Beta in Scarring / Praveen R. Arany, George X. Huang, Woo Seob Kim -- Chapter 15. Natural Vitamin E Tocotrienol against Neuroinflammation and Oxidative Stress / Cameron Rink, Savita Khanna -- Chapter 16. Inflammatory Cascades in Autoimmune Disease / Amita Aggarwal, Arpita Myles -- Chapter 17. Shear Stress and Vascular Inflammation / John Noel, Shampa Chatterjee -- Chapter 18. NGF and Its Receptor System in Inflammatory Diseases / Anupam Mitra, Smriti K. Raychaudhuri, Siba P. Raychaudhuri -- Section III. Nutrition & Therapeutics for Inflammatory Diseases -- Chapter 19. Inflammation, Oxidative Stress, and Antioxidants / Naveen Kaushal, Vivek Narayan, Ujjawal H. Gandhi, Shakira M. Nelson, Anil Kumar Kotha, K. Sandeep Prabhu --Chapter 20. Lipid Biomarkers of Inflammation / Ginger L. Milne -- Chapter 21. Physical Activity and Inflammation / Edite Teixeira de Lemos, Flávio Reis -- Chapter 22. Omega-6 and Omega-3 Polyunsaturated Fatty Acids and Inflammatory Processes / Philip C. Calder -- Chapter 23. Anti-Inflammatory Phytochemicals, Obesity, and Diabetes / Srujana Rayalam, MaryAnne Della-Fera, Clifton A. Baile -- Chapter 24. Anti-Inflammatory Nutraceuticals and Herbal Medicines for the Management of Metabolic Syndrome / George Q. Li, Ka H. Wong, Antony Kam, Xian Zhou, Eshaifol A. Omar, Ali Alqahtani, Kong M. Li, Valentina Razmovski-Naumovski, Kelvin Chan -- Chapter 25. Epigenetics and Nutriepigenomics in Chronic Inflammatory Lung Diseases / Saravanan Rajendrasozhan, Isaac K. Sundar, Irfan Rahman -- Chapter 26. Biologics / Ananya Datta Mitra, Debasis Bagchi, Siba P. Raychaudhuri, Smriti K. Raychaudhuri -- Chapter 27. Disease Modifying Anti-Rheumatic Drugs / Nigil Haroon, Vinod Chandran -- Chapter 28. Nonsteroidal Anti-Inflammatory Drugs / Alakendu Ghosh, Pradyot Sinhamahapatra.
  • Introduction -- Clinical Assessment of the Patient -- Dermatopathology -- Medical Management -- Mechanisms and Current Research -- Predominantly Lymphocytic Group -- Predominantly Neutrophilic Group -- Mixed Group -- End Stage Nonspecific Group -- Personal Experiences of Six Patients.
  • This clinical case book serves as a useful guide for dermatologists, internists, family practitioners, pediatricians, and anyone else charged with the care of the skin. The case-based format distinguishes this work from a reference-style textbook, instead allowing readers to relate the presented cases to their own patients. Clinical Cases in Autoimmune Blistering Diseases provides help and insight for clinicians in managing this group of serious and debilitating skin conditions, with each case serving as a springboard for further pursuit and more extensive training. It will enable those new to the field to begin to develop a literacy and competence in autoimmune blistering diseases, while experienced dermatologists will find new ways to sharpen their diagnostic and treatment skills.
  • Primary immunodeficiency diseases (PIDs) are a heterogeneous group of inherited disorders characterized by different defects in the development and function of the immune system. These defects render patients susceptible to a variety of infectious diseases. Knowledge of normal immunity and specific warning signs and symptoms can help physicians to identify those children with underlying PIDs.This book aims to increase the clinical awareness and knowledge of practicing clinicians regarding the diagnosis and management of PIDs. In order to achieve this goal, about 90 cases drawn from real life are presented, along with approximately 300 related questions. The selected case reports are the result of the invaluable cooperation of more than 40 scientists in the field of immunodeficiency. They focus both on the presenting features of patients with PIDs and on the required further investigation and management. Although the case scenarios relate to real histories, some modifications have been made for educational purposes. Each of the numbered cases is followed by the questions, their answers, and additional discussion. Each question focuses on a particular aspect of the PID under consideration, and the topics covered include clinical diagnosis, laboratory findings, molecular mechanisms, and therapy.This practical, case-oriented book will be an invaluable source of guidance on the diagnosis and treatment of patients with PIDs and will be relevant for those working in a variety of specialties and subspecialties.
  • The human immune response -- Organization of the immune system -- Innate immunity -- Antigen receptor genes, gene products, and co-receptors -- The major histocompatibility complex -- Antigens and antigen presentation -- B-cell development and differentiation -- T-cell development -- Cytokines and cytokine receptors -- Chemokines and chemokine receptors -- Lymphocyte adhesion and trafficking -- T-cell activation and tolerance -- Programmed cell death in lymphocytes and associated disorders -- Immunoglobulin function -- Regulatory T cells -- Helper T-cell subsets and control of the inflammatory response -- Cytotoxic T lymphocytes and natural killer cells -- Host defenses in the skin -- Host defenses at mucosal surfaces -- Complement in host deficiencies and diseases -- Phagocyte deficiencies -- Mast cells, basophils, and mastocytosis -- Eosinophils and eosinophilia -- Host defenses to extracellular bacteria -- Host defenses to intracellular bacteria -- Host defenses to spirochetes -- Host defenses to viruses -- Host defenses to protozoa -- Host defenses to helminths -- Approach to the evaluation of the immunodeficient patient -- Infections in the immunocompromised host -- Maturing of the fetal and neonatal immune system -- Aging and the immune system -- Primary antibody deficiencies -- Primary T-cell immunodeficiencies -- Inherited disorders of IFN-y-, IFN-a/€//\-, and NF-kB-mediated immunity -- HIV infection and acquired immunodeficiency syndrome -- External factors inducing immune deficiency -- Immunological mechanisms of airway diseases and pathways to therapy -- Urticaria, angioedema, and anaphylaxis -- Allergic reactions to stinging and biting insects -- Atopic and contact dermatitis -- Food allergy -- Eosinophil-associated gastrointestinal disorders -- Allergic disorders of the eye -- Drug hypersensitivity -- Occupational asthma -- Mechanisms of autoimmunity -- Interface of autoimmunity and immunodeficiency -- Systemic lupus erthematosus -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Sjögren's syndrome -- Scleroderma-systemic sclerosis -- Inflammatory muscle diseases -- Spondyloarthritis -- Small and medium vessel primary vasculitis -- Large-vessel vasculitides -- Systemic autoinflammatory syndromes -- Antiphospholipid syndrome -- Immunohematologic disorders -- Bullous diseases of the skin and mucous membranes -- Immunology of psoriasis -- Myasthenia gravis -- Multiple sclerosis -- Autoimmune peripheral neuropathies -- Immunologic renal diseases -- Inflammation and atherothrombosis -- Autoimmune thyroid diseases -- Diabetes and related autoimmune diseases -- Immunologic lung diseases -- Sarcoidosis -- Immunologic ocular disease -- Immunologic diseases of the gastrointestinal tract -- Inflammatory hepatobiliary diseases -- Principles of tumor immunology -- Tumor immunotherapy -- Lymphoid leukemias -- Lymphomas -- Monoclonal gammopathies -- Concepts and challenges in organ transplantation: rejection, immunosuppression, and tolerance -- Stem cell transplantation and immune reconstitution in immunodeficiency -- Hematopoietic stem cell transplantation for malignant diseases -- Thymic reconstitution -- Immunoglobulin therapy: replacement and immunomodulation -- Gene therapy -- Glucocorticoids -- Immunomodulating pharmaceuticals -- Protein kinase antagonists as therapeutic agents for immunological and inflammatory disorders -- Vaccines -- Immunotherapy of allergic disease -- Biologic modifiers of inflammatory diseases -- Assessment of proteins of the immune system -- Flow cytometry -- Assessment of functional immune responses -- Assessment of neutrophil function -- Assessment of human allergic diseases -- Molecular methods.
  • pt. 1. The growth of lupus -- 1. Lupus: An introduction -- 2. What is lupus? -- pt. 2. Lupus organ by organ -- 3. Skin --4. Tendons and joints -- 5. Kidney -- 6. The brain -- 7. Heart and blood vessels -- 8. Liver and gastrointestinal tract -- 9. Blood -- pt. 3. Diagnosis and treatment -- 10. Diagnosing lupus -- 11. Treatment -- pt. 4. Lupus-like disorders -- 12. Sjögren's syndrome -- 13. Hughes syndrome (the antiphospholipid syndrome) -- 14. Mixed connective tissue disease (and overlap syndromes) -- 15. Vasculitis -- pt. 5. Lupus-related topics -- 16. Lupus-related topics.
  • "Presents recent research developments to aid fighting fungal infections The currently available means of combating fungal infections are still weak and clumsy. The application of fungal genomics offers an unparalleled opportunity to develop novel antifungal drugs. Interestingly, several novel antifungal drug targets have already been identified and validated. However, it is too early to expect any novel antifungal drug as drug discovery programs are still in their infancy. In addition to classical and genomic approaches to drug discovery, traditional knowledge derived from natural products and phytomedicine can provide a multitude of alternative modes of combating fungal infection. This book comprises 20 chapters on various aspects pertaining to fungal diseases in human and animals, their reservoir, fungal pathogenesis, their management and recent advances in their treatment. Issues of antifungal drug toxicity, especially nephrotoxicity, are also discussed. The development of resistance in fungal pathogens, including multidrug resistance and its mechanism, is dealt with in two chapters. Diverse diagnostic approaches to fungal infections are also reviewed. The combinational drug strategies used in combating invasive fungal infections are addressed in detail. The management of pulmonary mycoses in stem cell transplantation is also given special focus. Novel antifungal drugs (synthetic and herbal), fungal vaccines, and metabolic pathways as drug targets are discussed in detail in three different chapters. Subsequently the roles of innate immunity, cytokine therapy and immunomodulators in the treatment of fungal infections are elaborated upon. As novel drug delivery systems have a great potential for modifying the pharmacokinetics of medications, the last chapter takes this fact into consideration in its examination of state-of-the-art delivery systems in controlling fungal infections."--Publisher's website.
  • An overview of the translational dilemma and the need for translational systems biology of inflammation / Yoram Vodovotz and Gary An -- Part I: Complex systems methods and applications. Translational equation-based modeling / Gilles Clermont ; Agent-based modeling in translational systems biology / Scott Christley and Gary An ; Analysis of heart rate variability / Patrick R. Norris ; Analysis of ventilatory pattern variability / Thomas E. Dick [and seven others] -- Part II. Translational modeling of sepsis and trauma. Disorder of systemic inflammation in sepsis and trauma: a systems perspective / Kent R. Zettel II and Timothy R. Billiar ; Multi-scale equation-based models: insights for inflammation and physiological variability / Jeremy D. Scheff ; Integrating data driven and mechanistic models of the inflammatory response in sepsis and trauma / Nabil Azhar [and five others] ; In silico trials and personalized therapy for sepsis and trauma / Yoram Vodovotz, John Bartels, and Gary An -- Part III: Translational modeling of wound healing. Disorder of localized inflammation in wound healing: a systems perspective / Sashwati Roy, Amitava Das, and Chandan K. Sen ; Equation-based models of wound healing and collective cell migration / Julia Arciero and David Swigon ; Agent-based models of wound healing / Jordan R. Stern [and three others] -- Part IV: Translational modeling of host-pathogen interactions. Modeling host-pathogen interactions in necrotizing enterocolitis / Julia Arciero, Jared Barber, and Moses Kim ; Modeling host-vector-pathogen immuno-inflammatory interactions in malaria / Yoram Vodovotz [and nine others] -- Part V: Future perspectives : translation to implementation. The rationale and implementation of translational systems biology as a new paradigm for the study of inflammation / Gary An and Yoram Vodovotz -- Index.
  • Communication in the immune system by connexin channels / E. Oviedo-Orta and W. Howard Evans -- Gap junctions and connexins in the hematopoietic-immune system : structural considerations / T. Krenacs, I. Zsakovics and M. Rosendaal -- Approaches for studying the role(s) of gap junctions in the immune system / A.M. Glass, T.D. Nguyen, S. Taffet -- Gap junctions in antigen presenting cells / P.J. Saez, K.F. Shoji, J.C. Saez -- Connect the immune system : roles of gap junctions in antigen presentation and T cell activation / B. Pang, J. Neefjes -- Gap junctions and connexins in the immune defence against tumors / F. Salazar-Onfray -- Connexins in atherosclerosis / L. Burnier, B.R. Kwak -- Connexins in lung function and inflammation / M. Chanson, M. Koval -- The effect of oxidative stress on connexins in the vasculature / M. Billaud ... [et al.] -- The regulation of gap junctions and cellular coupling within the microvasculature in response to acute inflammation / D. Lidington, K. Tyml -- Impact of microglial activation on astroglial connexin expression and function in brain inflammation / C. Giaume ... [et al.] -- A role for connexins in inflammatory disorders of the epidermis / S. Donnelly, P. Martin -- Translating basic research on Cx43 gap junctions into therapies for reducing scarring and cardiac arrhythmia / J.M. Rhett ... [et al.] -- Connexin-based therapeutic approaches to inflammation in the central nervous system / J. Zhang ... [et al.] -- Enhancing epithelial tissue repair and reducing inflammation by targeting connexins / D.L. Becker ... [et al.].
  • History and Prospects of Coxiella burnetii Research / Karim E. Hechemy -- Phylogenetic Diversity, Virulence and Comparative Genomics / Erin J. van Schaik and James E. Samuel -- Defense Mechanisms Against Oxidative Stress in Coxiella burnetii: Adaptation to a Unique Intracellular Niche / Katja Mertens and James E. Samuel -- Lipopolysaccharide of Coxiella burnetii / Craig T. Narasaki and Rudolf Toman -- Components of Protective Immunity / Guoquan Zhang, Yan Zhang and James E. Samuel -- Proteome of Coxiella burnetii / Robert Ihnatko, Edward Shaw and Rudolf Toman -- Coxiella Subversion of Intracellular Host Signaling / S. Kauser Hussain and Daniel E. Voth -- The Coxiella burnetii Parasitophorous Vacuole / Eric Ghigo, María I. Colombo and Robert A. Heinzen -- Coxiella burnetii Secretion Systems / Justin A. McDonough, Hayley J. Newton and Craig R. Roy -- Role of Lipids in Coxiella burnetii Infection / Stacey D. Gilk -- Axenic Growth of Coxiella burnetii / Anders Omsland -- Developmental Biology of Coxiella burnetii / Michael F. Minnick and Rahul Raghavan -- Genetic Manipulation of Coxiella burnetii / Paul A. Beare -- Role of Innate and Adaptive Immunity in the Control of Q Fever / Christian Capo and Jean-Louis Mege -- Immune Response and Coxiella burnetii Invasion / Amira Ben Amara, Yassina Bechah and Jean-Louis Mege -- Antigenic Analysis for Vaccines and Diagnostics / Laura R. Hendrix and Chen Chen -- Epidemic Q Fever in Humans in the Netherlands / Wim van der Hoek, Gabriëlla Morroy, Nicole H. M. Renders, Peter C. Wever and Mirjam H. A. Hermans, et al. -- Coxiella-like Endosymbionts / Jianmin Zhong -- Molecular Typing of Coxiella burnetii (Q Fever) / Robert F. Massung, Sally J. Cutler and Dimitrios Frangoulidis.
  • Signal transduction in DC differentiation: winged messengers and Achilles' heel / Inna Lindner ... [et al.] -- Shaping naive and memory CD8+ T cell responses in pathogen infections through antigen presentation / Gabrielle T. Belz ... [et al.] -- Understanding the role of innate immunity in the mechanism of action of the live attenuated yellow fever vaccine 17D / Troy D. Querec and Bali Pulendran -- The function of local lymphoid tissues in pulmonary immune responses / Juan Moyron-Quiroz ... [et al.] -- The yin and yang of adaptive immunity in allogeneic hematopoietic cell transplantation: donor antigen-presenting cells can either augment or inhibit donor T cell alloreactivity / Jian-Ming Li and Edmund K. Waller -- It's only innate immunity but I like it / Emanuela Marcenaro ... [et al.] -- Innate tumor immune surveillance / Mark J. Smyth, Jeremy Swann, and Yoshihiro Hayakawa -- Regulation of adaptive immunity by cells of the innate immune system: bone marrow natural killer cells inhibit T cell proliferation / Prachi P. Trivedi ... [et al.] -- Induction and maintenance of CD8+ T cells specific for persistent viruses / Ester M.M. van Leeuwen, Ineke J.M. ten Berge, and René A.W. van Lier -- Germinal center-derived B cell memory / Craig P. Chappell and Joshy Jacob -- CD28 and CD27 costimulation of CD8+ T cells: a story of survival / Douglas V. Dolfi and Peter D. Katsikis -- CD38: an ecto-enzyme at the crossroads of innate and adaptive immune responses / Santiago Partida Sánchez ... [et al.] -- Vascular leukocytes: a population with angiogenic and immunosuppressive properties highly represented in ovarian cancer / George Coukos ... [et al.] -- CD4+ T cells cooperate with macrophages for specific elimination of MHC class II-negative cancer cells / Alexandre Corthay -- Receptors and pathways in innate antifungal immunity: the implication for tolerance and immunity to fungi / Teresa Zelante ... [et al.].
  • Protective effects of type1 interferon in models of intestinal inflammation / Jongdae Lee ... [et al.] -- NK/DC complot / Emanuela Marcenaro ... [et al.] -- Detection of microbes by natural killer T cells / Yuki Kinjo, Mitchell Kronenberg -- Ontogeny of the secondary antibody response, origins and clonal diversity / Craig P. Chappell, Joseph Dauner, Joshy Jacob -- Role of PI3K signalling in the B cell response to antigen / Daniel J. Hodson, Martin Turner -- CD28, old dog, new tricks / Jayakumar R. Nair, Cheryl Rozanski, Kelvin P. Lee -- Initial TCR transgenic precursor frequency alters functional behaviour of CD8 T cells responding to acute infection / Thomas Wirth, John T. Harty -- Effects of cancer immunotherapy regimens on primary vs. secondary immune responses and the potential impact on long-term antitumor responses / Kory L. Alderson, William J. Murphy -- New insights into classical costimulation of CD8+ T cell responses / Christine M. Bucks, Peter D. Katsikis -- Peripheral tolerance induction by lymph node stroma / Erika D. Reynoso, Je-Wook Lee, Shannon J. Turley.
  • Is transcription the dominant force during dynamic changes in gene expression? -- MicroRNAs: key components of immune regulation -- KIR/HLA: genetic clues for a role of NK cells in the control of HIV -- Natural killer cell licensing during viral infection -- Bridging innate NK cell functions with adaptive immunity -- Control of innate immunity by memory CD4 T cells -- Strategies and implications for prime-boost vaccination to generate memory CD8 T cells -- Blimp1: driving terminal differentiation to a T -- New role for myeloid HO-1 in the innate to adaptive crosstalk and immune homeostasis -- Impact of differential glycosylation on IgG activity -- Murine model of chronic respiratory inflammation -- Incorporation of innate immune effector mechanisms in the formulation of a vaccine against HIV-1 -- Influenza vaccines: what do we want and how can we get it?
  • 1. Type III interferons (IFNs): emerging master regulators of immunity -- 2. Stability of regulatory T cells undermined or endorsed by different type-1 cytokines -- 3. The role of Il-12 and type I interferon in governing the magnitude of CD8 T cell responses -- 4. Functional diversity of human dendritic cells -- 5. Selective dependence of kidney dendritic cells on CX₃CR1, implications for glomerulonephritis therapy -- 6. Mechanisms of memory T cell activation and effective immunity -- 7. Molecular programming of immunological memory in natural killer cells -- 8. Induction of immune tolerance to dietary antigens -- 9. The role of p110ð in the development and activation of B lymphocytes -- 10. Immune memory and exhaustion: clinically relevant lessons from the LCMV model -- Index.
  • Hereditary angioedema in 2011 / Marco Cicardi -- Hereditary angioedema : diagnosis and pathogenic mechanisms / Allen P. Kaplan -- Current options for the acute treatment and prophylaxis of hereditary angioedema / Laraib Tabba & Timothy J. Craig -- Novel C1 inhibitors for hereditary angioedema / Henriette Farkas & Lilian Varga -- New drug targets and future direction : ecallantide / Jonathan A. Bernstein -- New drug targets and future direction : icatibant / Konrad Bork -- Index.
  • Current approaches to allergic rhinitis / Cristoforo Incorvaia -- Allergic rhinitis : symptoms / Nerin N. Bahceciler & Nilufer Galip -- Allergic rhinitis : causes and pathogenesis / Giovanni Passalacqua -- Diagnostic tests in allergic rhinitis / Cristoforo Incorvaia & Franco Frati -- Nasal steroids in allergic rhinitis / Davide Caimmi, Silvia Caimmi, Roberto Raschetti, Ilaria Brambilla & Gian Luigi Marseglia -- Other treatments / Takeshi Nabe -- Index.
  • ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.
  • 1. Cross-disciplinary research stirs new challenges into the study of the structure, function, and systems biology of complement / Dimitrios Mastellos and John D. Lambris -- 2. Liver regeneration: a link to inflammation through complement / Robert A. DeAngelis, Maciej M. Markeiwski, and John D. Lambris -- 3. The Role of third complement component (C3) in homing of hematopoietic stem/progenitor cells into bone marrow / Ryan Reca ... [et al.] -- 4. Complement system and the eye / Purushottam Jha ... [et al.] -- 5. To regeneration ... with complement / Panagiotis A. Tsonis, John D. Lambris, and Katia Del Rio-Tsonis -- 6. Self, non-self and danger: a complementary view / Jörg Köhl -- 7. gClqR/p33 serves as a molecular bridge between the complement and contact activation systems and is an important catalyst in inflammation / Berhane Ghebrehiwet ... [et al.] -- 8. Possible immunoprotective and angiogenesis-promoting roles for malignant cell-derived prostasomes: a new paradigm for prostatic cancer? / Kristina Nilsson Ekdahl ... [et al.] -- 9. Diversified components of the bony fish complement system: more genes for robuster innate defense? / Miki Nakao ... [et al.] -- 10. C5b-9 complement complex in autoimmune demyelination: dual role in neuroinflammation and neuroprotection / Horea Rus, Cornelia Cudrici, and Florin Niculescu -- 11. The Double-edged flower: roles of complement protein C1q in neurodegenerative diseases / Andrea J. Tenner and Maria I. Fonseca -- 12. The Role of the complement system in the pathogenesis of experimental autoimmune encephalomyelitis and multiple sclerosis / Nóra Terényi, József Prechl, and Anna Erdei -- 13. The Complement system: a potential target for stroke therapy / J. Mocco ... [et al.] -- 14. Observations on complement activity in the two-stage inflammatory/hemostatic response in the baboon and human models of E. coli sepsis and endotoxemia / Fletcher B. Taylor, Jr., Eric Hack, and Florea Lupu -- 15. Complement activation during sepsis in humans / Heike Schreiber ... [et al.] -- 16. Three distinct profiles of serum complement C4 proteins in pediatric systemic lupus erythematosus (SLE) patients: tight associations of complement C4 and C3 protein levels in SLE but not in healthy subjects / Yee-Ling Wu ... [et al.] -- 17. A Minimum CR2 binding domain of C3d enhances immunity following vaccination / Joseph F. Bower and Ted M. Ross -- 18. Structure and function of ficolins / Yuichi Endo, Yu Liu, and Teizo Fujita -- 19. Role of mannose-binding lectin (MBL2) genotyping in predicting the risk of recurrent otitis media (rOM) / Lieve Nuytinck ... [et al.] -- 20. Conformational complexity of complement component C3 / Bert J.C. Janssen and Piet Gros -- 21. Disease-associated sequence variations in factor H: a stuctural biology approach / Andrew P. Herbert ... [et al.] -- 22. Transdermal pharmacology of small molecule cyclic C5a antagonists / Lavinia M. Proctor ... [et al.] -- 23. Inactivation of complement by recombinant human C3 derivatives / Edzard Spillner, Johanna Kölln, and Reinhard Bredehorst -- 24. Complement analysis in clinic and research / Tom E. Mollnes and Michael Kirschfink -- 25. Cell-bound complement activation products (CB-CAPs) as a source of lupus biomarkers / Sarah J. Calano ... [et al.].
  • Pentraxins in Humoral Innate Immunity / Antonio Inforzato, Barbara Bottazzi, Cecilia Garlanda, Sonia Valentino and Alberto Mantovani -- Galectins as Pattern Recognition Receptors: Structure, Function, and Evolution / Gerardo R. Vasta -- The Role of Innate Immunity in Trafficking of Hematopoietic Stem Cells - An Emerging Link Between Activation of Complement Cascade and Chemotactic Gradients of Bioactive Sphingolipids / Mariusz Z. Ratajczak, ChiHwa Kim, Wan Wu, Dong Myung Shin and Ewa Bryndza, et al. -- Interaction of the Microbiome with the Innate Immune Response in Chronic Wounds / Elizabeth A. Grice and Julia A. Segre -- Pathogenic Microbes and Community Service Through Manipulation of Innate Immunity / George Hajishengallis, Jennifer L. Krauss, Shuang Liang, Megan L. McIntosh and John D. Lambris -- A Conserved Host and Pathogen Recognition Site on Immunoglobulins: Structural and Functional Aspects / Bruce D. Wines, Halina M. Trist, William Farrugia, Chloe Ngo and John Trowsdale, et al. -- Advances in Understanding the Structure, Function, and Mechanism of the SCIN and Efb Families of Staphylococcal Immune Evasion Proteins / Brandon L. Garcia, Kasra X. Ramyar, Daniel Ricklin, John D. Lambris and Brian V. Geisbrecht -- Granzyme B: A New Crossroad of Complement and Apoptosis / Mario Perl, Stephanie Denk, Miriam Kalbitz and Markus Huber-Lang -- Role of C3, C5 and Anaphylatoxin Receptors in Acute Lung Injury and in Sepsis / Markus Bosmann and Peter A. Ward -- Complement Involvement in Neovascular Ocular Diseases / Ryoji Yanai, Aristomenis Thanos and Kip M. Connor -- Platelets, Complement, and Contact Activation: Partners in Inflammation and Thrombosis / Osama A. Hamad, Jennie Bäck, Per H. Nilsson, Bo Nilsson and Kristina N. Ekdahl -- Nuclear Factor-κB in Immunity and Inflammation: The Treg and Th17 Connection / Qingguo Ruan and Youhai H. Chen -- Function of Act1 in IL-17 Family Signaling and Autoimmunity / Ling Wu, Jarod Zepp and Xiaoxia Li -- Differential Effect of Inhibiting MD-2 and CD14 on LPS- Versus Whole E. coli Bacteria-Induced Cytokine Responses in Human Blood / D. Christiansen, O. L. Brekke, J. Stenvik, J. D. Lambris and T. Espevik, et al. -- Zebrafish: Model for the Study of Inflammation and the Innate Immune Response to Infectious Diseases / Beatriz Novoa and Antonio Figueras -- Monocyte-derived Inflammatory Dendritic Cells in the Granuloma During Mycobacterial Infection / Heidi A. Schreiber and Matyas Sandor -- NK/DC Crosstalk in Anti-viral Response / Emanuela Marcenaro, Simona Carlomagno, Silvia Pesce, Alessandro Moretta and Simona Sivori -- Innate-Adaptive Crosstalk: How Dendritic Cells Shape Immune Responses in the CNS / Benjamin D Clarkson, Erika Héninger, Melissa G Harris, JangEun Lee and Matyas Sandor, et al. -- Nutritional Immunity: Homology Modeling of Nramp Metal Import / Mathieu F. M. Cellier.
  • The Interleukin-1 Family / Charles A. Dinarello and Mihai G. Netea -- IL-6 and Inflammatory Diseases / Daisuke Kamimura, Yasunobu Arima, Toshio Hirano, Hideki Ogura, and Masaaki Murakami -- The Roles of IL-17A and IL-17F in Infection and Inflammatory Disorders / Harumichi Ishigame and Susumu Nakae -- IL-18 / Wen Li, Yoshimasa Tanaka, and Haruki Okamura -- Interleukin-21: a Pleiotropic Mediator of Immunity and Inflammation with Broad Therapeutic Potential / Rosanne Spolski and Warren J. Leonard -- Interleukin-22: A Bridge Between Epithelial Innate Host Defense and Immune Cells / Xiaoting Wang and Wenjun Ouyang -- IL-23 in Health and Disease / Jonathan P. Sherlock, Luis A. Zuniga, and Daniel J. Cua -- IL-36: An Epithelial Cytokine Important in Psoriasis / John E. Sims, Solenne Vigne, Cem Gabay, and Jennifer E. Towne -- Anti-TNF Therapy: 20 Years from Our First Therapeutic Adventure / Jagdeep Nanchahal, Peter Taylor, Richard Williams, and Marc Feldmann -- Interleukin-25: Key Initiator of Type 2 Immune Responses / Hiroshi Nakajima, Tomohiro Tamachi, and Koichi Hirose -- Interleukin-33: Multifunctional Alarmin that Promotes Both Health and Disease / Kazufumi Matsushita and Tomohiro Yoshimoto -- Thymic Stromal Lymphopoietin (TSLP) / Steven F. Ziegler, Florence Roan, Bryan D. Bell, Thomas A. Stoklasek, Masayuki Kitajima, and Hongwei Han -- Interleukin-10: Cytokines in Anti-inflammation and Tolerence / Ashleigh Howes, Philippa Stimpson, Paul Redford, Leona Gabrysova, and Anne O'Garra -- Interleukin-27: Regulation of Immune Responses and Disease Development by a Pleiotropic Cytokine with Pro- and Anti-inflammatory Properties / Izuru Mizoguchi, Kaname Higuchi, Kana Mitobe, Ren Tsunoda, Junichiro Mizuguchi, and Takayuki Yoshimoto -- Interleukin-35: A Novel Mediator of Peripheral Tolerance / Greg M. Delgoffe and Dario A.A. Vignali.
  • Cytokines and the brain 2008
  • Introduction to cytokines as targets for immunomodulation / Theresa L. Whiteside -- Cytokine measurement tools for immunotoxicology / Rob J. Vandebriel -- The relevance of the T1/T2 paradigm in immunotoxicology: example of drug hypersensitivity reactions / Hervé Lebrec and John Vasilakos -- Microbial exploitation and subversion of the human chemokine network / James E. Pease -- The use of cytokines in the identification and characterization of chemical allergens / Rebecca J. Dearman and Ian Kimber -- Inflammatory cytokines and lung toxicity / Debra L. Laskin ... [et al.] -- Cytokine polymorphisms and relationship to disease / Berran Yucesoy ... [et al.] -- Effects of drugs of abuse on cytokine responses / Stephen B. Pruett -- Preclinical approaches for safety assessment of cytokines / Peter T. Thomas and Melissa S. Beck-Westermeyer -- Flu-like syndrome and cytokines / Jacques Descotes and Thierry Vial -- Cytokine-induced vascular leak syndrome / Roxana G. Baluna -- Cytokines and autoimmune diseases: from the control of autoimmune diseases with anti-cytokine treatment to the induction of autoimmunity with cytokine treatment / Pierre Miossec -- Evaluation of antibodies in clinical trials of cytokines / Steven Swanson -- Cytokines and pharmacokinetic drug interactions / Kenneth W. Renton -- Evaluation of the immunological effects of cytokines administered to patients with cancer / Michael J. Robertson -- Clinical adverse effects of cytokines on the immune system / Thierry Vial and Jacques Descotes.
  • 1. Behavioral Effects of Cytokines: A Psychiatrist's Perspective / Ziad Kronfol -- 2. Worried to Death? Stress, Worry, and Immune Dysregulation in Health and HIV -- 3. Psychological Stress and Its Relationship to Cytokines and Inflammatory Diseases / Rama Murali, Margaret D. Hanson, and Edith Chen -- 4. Role of Cytokines in Depression / Ghanshyam N. Pandey and Yogesh Dwivedi -- 5. Loneliness, Dysphoria, Stress, and Immunity: A Role for Cytokines / Louise C. Hawkley, Jos A. Bosch, Christopher G. Engeland, Phillip T. Marucha, and John T. Cacioppo -- 6. Stress, Cytokines, and Peripheral Analgesia / Peter John Cabot -- 7. Alexithymia, Stress, and Immunity / Olivier Guilbaud, Maurice Corcos, and Philippe Jeammet -- 8. Roles of Mu-Opioid Receptor and Endogenous Opiates in Stress-Induced Immunosuppression / Jennifer Kelschenbach, Horace H. Loh, and Sabita Roy -- 9. Stress, Opioid Peptides, and Immune Reponse / Javier Puente, Marion E. Wolf, M. Antonieta Valenzuela, and Aron D. Mosnaim -- 10. Met-Enkephalin in Oxidative Stress / Tihomir Balog, Sandra Soboc̆anec, Vis̆nja S̆verko, Helena Haberstock-Debić, and Tatjana Marotti -- 11. Chronic Stress Induces Death of Lymphocytes / Erwei Sun, Lixin Wei, Arthur I. Roberts, Catherine Liu, and Yufang Shi -- 12. Interleukin-10 and the Hypothalamic--Pituitary--Adrenal Axis / Eric M. Smith, Huolin Tu, and Thomas K. Hughes, Jr. -- 13. Cytokines, Stress, and Depression / Adrian J. Dunn -- 14. Immunoconversion in Acute Phase Response / Istvan Berczi, Andres Quintanar-Stephano, and Kalman Kovacs -- 15. Interferon in Health and Disease / Nachum Dafny, Pamela B. Yang, and Stanley A. Brod -- 16. Neuropeptide Precursor Processing in Immunocytes: Involvement in Neuroimmune Communication / Robert Day and Michel Salzet -- 17.Clinical Relevance of Opioid-Induced Immunosuppression: Are All Drugs Similar? / Paola Sacerdote, Sivia Franchi, and Cataldo Martucci -- 18. Human Retroviruses and the Cytokine Network / Massimo Alfano and Guido Poli -- 19. Psychiatric Toxicity of Interferon: A Model for Understanding the Etiology of Major Depression and Chronic Fatigue Syndrome? -- 20. Role of Genetic Predisposition, Cytokines, and Neuroendocrine Response in Development of Thyroid Autoimmunity / Antonio Martocchia and Paolo Falaschi -- 21. Gender Differences, Stress, and Immunity / Nicholas P. Plotnikoff and Robert E. Faith.
  • Dendritic cells 2009
  • The central role of dendritic cells in immunity / Jessica Chu and Russell D. Salter -- Dendritic cells in cancer: emergence of the discipline / Michael R. Shurin and Michael T. Lotze -- Part I. Alterations of the dendritic cell system in cancer -- Tumor-infiltrating dendritic cells: the pathologist's perspective / Dmitry W. Gutkin -- Functional defects of dendritic cells in cancer / Mikhail M. Dikov and Irina S. Chekneva -- General properties of dendritic cell populations in cancer / Benjamin J. Daniel, Duane P. Jeansonne, Suzanne R. Thibodeaux, and Tyler J. Curiel -- Elimination of dendritic cells in cancer ? Viktor Umansky and Dirk Schadendorf -- Part II. Mechanisms of dendritic cell dysfunction in cancer -- Tumor-derived factors responsible for dendritic cell dysfunction / Alberto Pinzon-Charry and J. Alejandro López -- Tumor-derived exosomes as dendritic cell modulators / Roberta Valenti ... [et al.] -- Signaling pathways mediating dendritic cell dysfunction in cancer / Jing Yang and Qing Yi -- A role for STAT3 in dendritic cell regulation by tumor-derived factors / Dmitry I. Gabrilovich -- Tumor-associated inflammation and impact of dendritic cell function / Zoltan Pos ... [et al.] -- Changes in dendritic cells in cancer and aging / Annabelle Grolleau-Julius and Raymond L. Yung -- Stress, immunity and dendritic cells in cancer / Rachel Kohman and Alexander W. Kusnecov -- Cancer therapy and dendritic cell immunomodulation / Galina V. Shurin, Neil Amina, and Michael R. Shurin -- Part III. Role of dendritic cells in tumor escape -- Role IDO in dendritic cell differentiation and function in cancer / Alexey Popov and Joachim L. Schultze -- Dendritic cells: from inducers of specific T-cell responses to promoters of angiogenesis / George Coukos and Fabian Benencia -- Protumorigenic function of dendritic cells / Anjli Kukreja -- Dendritic cell maturation versus polarization in tumor escape / Michael W. Lipscomb, Walter J. Storkus, and Amy K. Wesa -- Part IV. Dendritic cells in cancer: clinical aspects -- Trafficking of dendritic cells in the tumor environment / Zoya R. Yurkovetsky and Ghena N. Yurkovetsky -- Dendritic cells in tumor-draining lymph nodes / Alistair J. Cochran ... [et al.] -- Dendritic cell vaccines in cancer: obstacles to overcome / Ezra D. Mirvish, Rebecca G. Pomerantz, Louis D. Falo, and Larisa J. Geskin -- How best to generate dendritic cells from patients with cancer and how best to use them for immunotherapeutic purposes / Mark M. Aloysius, Richard A. Robins, and Oleg Eremin -- Genetically modified dendritic cells in cancer immunotherapy / Brian J. Morrison ... [et al] -- Dendritic cell tumors / Lourdes R. Ylagan -- Future directions in dendritic cell research in cancer / Madhav V. Dhodapkar.
  • Allergic contact dermatitis / M.D. Gober, A.A. Gaspari -- Immune privilege and the skin / T. Ito ... [et al.] -- Immunobiology of acute cytotoxic drug reactions / B.J. Nickoloff -- Psoriasis / F.O. Nestle -- Atopic dermatitis in 2008 / L.S. Chan -- Cutaneous Lupus erythematosus : molecular and cellular basis of clinical findings / A. Kuhn, R. Sontheimer -- Bullous pemphigoid and related subepidermal autoimmune blistering diseases / E.B. Olasz, K.B. Yancey -- Pemphigus vulgaris and its active disease mouse model / M. Amagai -- Pemphigus foliaceus / D. Dasher, D. Rubenstein, L. Diaz -- Autoimmunity to type VII collagen : Epidermolysis bullosa acquisita / J. Remington ... [et al.] -- Pathomechanisms of Lichen planus autoimmunity elicited by cross-reactive T cells / T. Shiohara ... [et al.] -- Autoimmune etiology of generalized vitiligo / I.C. Le Poole, R.M. Luiten -- The genetics of generalized vitiligo / R.A. Spritz -- Scleroderma / A.C. Gilliam -- Alopecia areata / L.E. King Jr., K.J. McElwee, J.P. Sundberg -- Dermatomyositis / M.S. Krathen, D. Fiorentino, V.P. Werth -- Novel mechanism for therapeutic action of IVIg in autoimmune blistering dermatoses / D. Michael, S.A. Grando -- Skin involvement in systemic autoimmune diseases / S. Rashtak, M.R. Pittelkowo -- Therapeutics and immune-mediated skin disease / K.B. Gordon, R. Satoskar.
  • Development of novel vaccines gives an overview of the tasks in basic research leading to the final product â" the vaccine and its applications, belonging to the most complex biologics in the pharmaceutical field. Distinct from most textbooks in the vaccine arena, the current issue focuses on the translational aspect, namely, how research results can be transformed into life-saving medical interventions. Each chapter of the book deals with one important paradigm for the development of novel vaccines, along the value chain towards the final vaccine, and furthermore, with the inevitable tools required for this process. Contributions are prepared by teams of scientists, all of whom are experts in the field, most of them anchored in biomedical organizations devoted to translational culture, thereby lighting the certain topics from different views. This volume is a must read for researchers engaged in vaccine development and who really want to see their research results to become a product.
  • "For decades, lymphatic vessels were considered to be of "lesser significance" than blood vessels, and the fundamental importance of lymphatic vessels for physiological tissue homeostasis and their involvement in many pathological processes have only recently been fully appreciated. It is clear by now that all higher vertebrates possess a lymphatic vessel system, and that malfunctioning of the lymphatic vasculature has severe pathophysiological consequences. Still, many central aspects of the developmental origin, growth control and regulation of lymphatic vessels are not sufficiently understood. This volume of 'Advances in anatomy, embryology, and cell biology' focuses on the lymphatic vascular system from a developmental point of view, presenting exciting recent advances in elucidating the development and molecular control of lymphatic vessels. A collection of focused reviews, written by respected experts, describes ostensively how advanced genetic models and state-of-the-art imaging are being used to decipher the action of transcriptional programs, growth factors and matrix components in the regulation of lymphatic endothelial cell behavior. A synopsis is provided for each chapter, concisely highlighting the main points"--Publisher's description.
  • Common themes in lymphoid organ development -- Development of lymph nodes in humans and rodents -- Programmed and nascent gut-associated organized lymphoid tissues -- Single complexity : the spleen -- Dsassembling the puzzle : effect of aging.
  • Diagnostic Immunohistochemistry presents the latest information and most reliable guidance on immunohistological diagnoses in surgical pathology. David J. Dabbs, MD and other leading experts bring you state-of-the-art coverage on genomic and theranostic applications, molecular anatomic pathology, immunocytology, Non-Hodgkin's lymphoma, and more. Additional features such as tables discussing antibody specifications, differential diagnosis boxes, ancillary anatomic molecular diagnostics, and full-color histological images ensure user-friendly coverage that makes key information easy to find and apply. The fully searchable text is also available online at, along with a downloadable image bank and access to Path Consult. This concise and complete resource is today's indispensable guide to the effective use of immunohistochemical diagnosis. Discusses diagnostic pitfalls through immunohistologic differential diagnosis wherever appropriate so you can provide the most accurate diagnoses. Presents chapters arranged by organ system for comprehensive coverage of all relevant information in a convenient and intuitive organization. Provides quick reference graphs for antibodies throughout the text that illustrate the frequency of immunostaining for a variety of antibodies in tumors. Includes Key Diagnostic Points boxes in every chapter for a quick summary of text areas that are of particular importance. Features an expert author for each chapter to ensure coverage of the current state of the art.
  • Dictionary of Contact Allergens: Chemical Structures, Sources and References / Christophe J. Le Coz and Jean-Pierre Lepoittevin, p. 1-254 -- Patch Testing with the Patients' Own Products / Peter J. Frosch, Johannes Geier, Wolfgang Uter and An Goossens, p. 255-280.

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