Lane Medical Library

Current Protocols in Chemical Biology provides validated protocols and overviews about specialized chemical techniques and tools for studies of biology and drug design. These tools include small-molecule design, synthesis, derivatization, handling, and detection as well as advances in laboratory automation, robotics, and medicinal chemistry as applied to high-throughput screening (HTS). Methods for modification of proteins, nucleic acids, carbohydrates and lipids for their use as tools in the study of particular biological systems are also included

Consists of a core publication dated Apr. 1997, and updated by supplements 1 (July 1997)-<57 (July 2010)>. Content is peer-reviewed protocols for flow and image cytometry updated quarterly.

ch. 1. Genetic Mapping -- ch. 2. Genotyping -- ch. 3. Somatic Cell Hybrids -- ch. 4. Cytogenetics -- ch. 5. Strategies for Large-Insert Cloning and Analysis -- ch. 6. Identifying Candidate Genes in Genomic DNA -- ch. 7. Searching Candidate Genes for Mutations -- ch. 8. Clinical Cytogenetics -- ch. 9. Clinical Molecular Genetics -- ch. 10. Cancer Genetics -- ch. 11. Transcriptional Profiling -- ch. 12. Vectors for Gene Therapy -- ch. 13. Delivery Systems for Gene Therapy -- ch. 14. Forensic Genetics -- ch. 15. Model Systems for the Analysis of Human Disease -- ch. 16. Automation and Robotics in Genetic Analysis -- ch. 17. Biochemical Genetics --ch. 18. High-Throughput Sequencing -- ch. 19. Mitochondrial Genetics -- ch. 20. Epigenetics -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Laboratory Guidelines, Equipment, and Stock Solutions -- Appendix 3. Commonly Used Techniques -- Appendix 4. Chromosome Karyotyping and Idiograms -- Appendix 5. Genetic Linkage Reference Maps: Access to Internet-Based Resources -- Appendix 6. Human-Mouse Comparative Maps -- Appendix. Suppliers.

ch. 1. Care and Handling of Laboratory Animals -- ch. 2. Induction of Immune Responses -- ch. 3. In Vitro Assays for Mouse Lymphocyte Function -- ch. 4. In Vivo Assays for Lymphocyte Function -- ch. 5. Immunofluorescence and Cell Sorting -- ch. 6. Cytokines and Their Cellular Receptors -- ch. 7. Immunologic Studies in Humans -- ch. 8. Isolation and Analysis of Proteins -- ch. 9. Peptides -- ch. 10. Molecular Biology -- ch. 11. Biochemistry of Cell Activation -- ch. 12. Detection and Analysis of HIV -- ch. 13. Complement -- ch. 14. Innate Immunity -- ch. 15. Animal Models for Autoimmune and Inflammatory Disease -- ch. 16. Antigen Processing and Presentation -- ch. 17. Engineering Immune Molecules and Receptors -- ch. 18. Ligand-Receptor Interactions in the Immune System -- ch. 19. Animal Models for Infectious Diseases -- ch. 20. Animal Models for Tumor Immunology -- ch. 21. Microscopy -- ch. 22. Isolation and Differentiation of Stem and Progenitor Cells -- Appendix 1. Abbreviations and Useful Data -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Immunological Techniques -- Appendix 4. The CD System of Leukocyte Surface Molecules -- Appendix 5. Suppliers.

Emerging technologies -- Microscopy -- Alpha proteobacteria -- Beta proteobacteria -- Enteric gamma proteobacteria -- Nonenteric gamma proteobacteria -- Delta proteobacteria -- Epsilon proteobacteria -- Firmicutes (low G+C gram positive) -- Actinobacteria (high G+C gram positive) -- Chlamydiae -- Spirochetes -- Other eubacteria -- Animal DNA viruses -- Animal RNA viruses -- Plant RNA viruses.

ch. 1. Escherichia coli, Plasmids, and Bacteriophages -- ch. 2. Preparation and Analysis of DNA -- ch. 3. Enzymatic Manipulation of DNA and RNA -- ch. 4. Preparation and Analysis of RNA -- ch. 5. Construction of Recombinant DNA Libraries -- ch. 6. Screening of Recombinant DNA Libraries -- ch. 7. DNA Sequencing -- ch. 8. Mutagenesis of Cloned DNA -- ch. 9. Introduction of DNA into Mammalian Cells -- ch. 10. Analysis of Proteins -- ch. 11. Immunology -- ch. 12. DNA-Protein Interactions -- ch. 13. Yeast -- ch. 14. In Situ Hybridization and Immunohistochemistry -- ch. 15. The Polymerase Chain Reaction -- ch. 16. Protein Expression -- ch. 17. Preparation and Analysis of Glycoconjugates -- ch. 18. Analysis of Protein Phosphorylation -- ch. 19. Informatics for Molecular Biologists -- ch. 20. Analysis of Protein Interactions -- ch. 21. Chromatin Assembly and Analysis -- ch. 22. Nucleic Acid Arrays -- ch. 23. Manipulating the Mouse Genome -- ch. 24. Generation and Use of Combinatorial Libraries -- ch. 25. Discovery and Analysis of Differentially Expressed Genes in Single Cells and Cell Populations -- ch. 26. Gene Silencing -- ch. 27. RNA-Protein Interactions -- ch. 28. Mammalian Cell Culture -- ch. 29. Mouse Phenotyping -- ch. 30. Metabolomics -- Appendix 1. Standard Measurements, Data, and Abbreviations -- Appendix 2. Commonly Used Reagents and Equipment -- Appendix 3. Commonly Used Techniques in Biochemistry and Molecular Biology -- Appendix 4. Suppliers -- Appendix 5. Vectors -- Appendix 6. Pathway Modulators and Inhibitors.

ch. 1. Neuroanatomical Methods -- ch. 2. Imaging -- ch. 3. Cellular and Developmental Neuroscience -- ch. 4. Gene Cloning, Expression, and Mutagenesis -- ch. 5. Molecular Neuroscience -- ch. 6. Neurophysiology -- ch. 7. Neurochemistry/Neuropharmacology -- ch. 8. Behavioral Neuroscience -- ch. 9. Preclinical Models of Neurologic and Psychiatric Disorders -- ch. 10. Human Neuroscience -- Appendix 1. Molecular Biology Techniques -- Appendix 2. Stock Solutions, Equipment, and Laboratory Guidelines -- Appendix 3. Commonly Used Techniques -- Appendix 4. Animal Techniques -- Appendix 5. Databases -- Suppliers.

Includes methods for isolating, maintaining, and differentiating embryonic and adult stem cells.

Prenatal care / Vern L. Katz -- Normal labor, delivery, newborn care, and puerperium / Kirsten J. Lund and James McManaman -- Obstetric analgesia and anesthesia / Joy L. Hawkins -- Early pregnancy loss / T. Flint Porter, D. Ware Branch, and James R. Scott -- Ectopic pregnancy / Beata E. Seeber and Kurt T. Barnhart -- Genetics in obstetrics and gynecology / Kenneth Ward -- Prenatal diagnosis / Lorraine Dugoff -- Drugs in pregnancy / Jerome Yankowitz -- Ultrasound in obstetrics / Santosh Pandipati and John C. Hobbins -- Assessment of fetal well-being / Catherine Y. Spong -- Preterm labor and post-term delivery / J. Chris Carey and Ronald S. Gibbs -- Premature rupture of the membranes / Ronald S. Gibbs -- Intrauterine growth restriction / Bronwen F. Kahn, John C. Hobbins, and Henry L. Galan -- Multiple gestation / Roger B. Newman and Charles Rittenberg -- Diabetes mellitus and pregnancy / E. Albert Reece and Carol J. Homko -- Hypertensive disorders of pregnancy / Mounira Habli and Baha M. Sibai -- Medical and surgical complications of pregnancy / Deborah Krakow -- Immunologic disorders in pregnancy / D. Ware Branch, Robert M. Silver, and Kjersti Aagaard-Tillery -- Obstetric and perinatal infections / Jill K. Davies and Ronald S. Gibbs -- Human immunodeficiency virus / Howard Minkoff -- Placenta previa and abruption / Helen H. Kay -- Breech, other malpresentations, and umbilical cord complications / Timothy E. Klatt and Dwight P. Cruikshank -- Stillbirth and intrauterine fetal demise / Robert M. Silver -- Complications of labor / Donald J. Dudley -- Complications of delivery / Larry C. Gilstrap and Edward R. Yeomans -- Operative vaginal delivery / James A. Bofill and James N. Martin, Jr. -- Cesarean delivery / James R. Scott and T. Flint Porter -- Psychologic disorders of pregnancy and the postpartum period / Michael W. O'Hara and Lisa S. Segre -- Office gynecology and surgical procedures / Marian D. Damewood, William R. Keye, Jr., and Charles C. Coddington III -- Gynecologic ultrasound / Mika Thomas and Bradley J. Van Voorhis -- Pediatric and adolescent gynecology / Ann J. Davis -- Contraception / Lisa Memmel and Melissa Gilliam -- Induced abortion / Sabrina Holmquist and Melissa Gilliam -- Pelvic and sexually transmitted infections / David A. Eschenbach --Benign vulvovaginal disorders / Lori A. Boardman and Colleen M. Kennedy -- Amenorrhea / David P. Cohen -- Abnormal uterine bleeding / Steven R. Goldstein -- Premenstrual syndrome / Robert L. Reid -- Androgen excess disorders / Richard S. Legro and Ricardo Azziz -- Infertility / Kristen P. Wright and Julia V. Johnson -- Endometriosis / Robert S. Schenken -- Menopause / Marcelle I. Cedars and Michele Evans -- Women's sexuality and sexual dysfunction / Rosemary Basson -- Chronic pelvic pain / Howard T. Sharp -- Perioperative evaluation / Jeff Peipert and Sarah Hammil -- Laparoscopic surgery / Joseph S. Sanfilippo and Lisa M. Roberts -- Hysteroscopic surgery / R. Stanford Williams -- Epidemiology, pathophysiology, and evaluation of pelvic organ support / John O. L. DeLancey -- Operative management of pelvic organ prolapse / Kris Strohbehn and Holly E. Richter -- Nonsurgical treatment of pelvic organ prolapse / Ingrid D. Nygaard -- Female urinary incontinence: epidemiology and evaluation / Peggy A. Norton --Operative management of urinary incontinence / Charles W. Nager and Amy R. Kane -- Nonsurgical management of urinary incontinence and overactive bladder / Baharak Amir and Alfred E. Bent -- Fecal incontinence and defecation disorders / Dee E. Fenner and Catherine Ann Matthews -- Leiomyomata / Arthur F. Haney -- Disorders of the breast / Mary L. Gemignani -- Vulvar and vaginal cancer / Natalie S. Gould and Joan L. Walker -- Cervical cancer / Robert L. Giuntoli II and Robert E. Bristow -- Human papillomavirus and the management of the abnormal pap test / Christine H. Holschneider -- Uterine cancer / David G. Mutch -- Ovarian and tubal cancers / Ilana Cass and Beth Y. Karlan -- Management of the adnexal mass / Susan A. Davidson -- Gestational trophoblastic neoplasms / Andrew John Li -- The special approach to solving the profession's liability crisis, improving patient safety, and preventing medical errors / Louis Weinstein and Jason K. Baxter -- Appendix: Evidence-based approach to obstetrics and gynecology / Ronald S. Gibbs.

Diagnosis -- History taking and the medical record -- The screening physical examination -- Vital signs, anthropometric data, and pain -- Non-regional systems and diseases -- The skin and nails -- The head and neck -- The chest : chest wall, pulmonary, and cardiovascular systems; the breasts -- Abdomen, perineum, anus, and rectosigmoid -- The urinary system -- The female genitalia and reproductive system -- Male genitalia and reproductive system -- The spine, pelvis and extremities -- The neurologic examination -- The mental status, psychiatric, and social evaluations -- The preoperative evaluation -- Principles of diagnostic testing -- Common laboratory tests.

Machine generated contents note: pt. I Principles of Assessment and Evaluation -- 1.Clinical Evaluation / Stephen F. Noil -- 2.The Physical Examination / Peter J. Moley -- 3.Assessment of Human Muscle Function / Jan Lexell -- 4.Electrodiagnostic Evaluation of the Peripheral Nervous System / Lawrence R. Robinson -- 5.Human Walking / Brian L. Bowyer -- 6.Imaging Techniques Relative to Rehabilitation / Angel Gomez -- 7.Diagnostic Ultrasound / Yi-Pin Chiang -- 8.Principles and Applications of Measurement Methods / Kathleen A. Hinderer -- 9.Functional Evaluation and Management of Self-care and Other Activities of Daily Living / Kristine L. Haerti -- 10.Disability Determination / Richard T. Katz -- 11.Applying the ICF in Rehabilitation Medicine / Alarcos Cieza -- 12.Systematically Assessing and Improving the Quality and Outcomes of Medical Rehabilitation Programs / Anne C. Hansen -- pt. II The Rehabilitation Team: Systems-Based Practice -- 13.Rehabilitation Team Function and Prescriptions, Referrals, and Order Writing / Amit Mehta -- 14.Psychological Aspects of Rehabilitation / Daniel E. Rohe -- 15.Speech, Language, Swallowing, and Auditory Rehabilitation / Jennifer Ryder -- 16.Sexuality and Disability / Andrei Krassioukov -- 17.Vocational Rehabilitation, Independent Living, and Consumerism / David Delambo -- 18.Community Participation and the Environment: Theoretical, Assessment and Clinical Implications / Daniel K. White -- 19.Systems-Based Practice of Physical Medicine and Rehabilitation / Jared Fleisher -- 20.Ethical Issues in Rehabilitation Medicine / Janet F. Haas -- 21.Interactions with the Medicolegal System / Steve R. Geiringer -- 22.International Aspects of the Practice of Rehabilitation Medicine / Chang-Il Park -- pt. III Major Conditions -- 23.Stroke Rehabilitation / Murray E. Brandstater -- 24.Traumatic Brain Injury / Tessa Hart -- 25.Multiple Sclerosis / Alexander Rae-Grant -- 26.Rehabilitation of Persons with Parkinson's Disease and Other Movement Disorders / Donna Moxley Scarborough -- 27.Rehabilitation of Spinal Cord Injury / Monifa Brooks -- 28.Adult Motor Neuron Disease / Gregory T. Carter -- 29.Peripheral Neuropathy / Maya Therattil -- 30.Myopathy / David D. Kilmer -- 31.Osteoarthritis / Sausheen Heslop -- 32.Disorders of the Cervical Spine / David I. Lipetz -- 33.Rehabilitation of Lumbar Spine Disorders: An Evidence-Based Clinical Practice Approach / Carlo Trevisan -- 34.Scoliosis and Other Spinal Deformities / Scott M. Paul -- 35.Upper Extremity Soft-Tissue Injuries / Kathleen Fink -- 36.Cumulative Trauma Disorders / Joanne Borg-Stein -- 37.Hand Disorders / Lynn H. Gerber -- 38.Foot Disorders / Lynn H. Gerber -- 39.The Prevention and Treatment of Osteoporosis / Gopi Kasturi -- 40.Rehabilitation of the Patient with Rheumatic Diseases / Lynn H. Gerber -- 41.Cardiac Rehabilitation / Matthew Bartels -- 42.Rehabilitation of the Patient with Respiratory Dysfunction / Eric Altschuler --43.Burn Rehabilitation / M. Catherine Spires -- 44.Rehabilitation for Patients with Cancer Diagnoses / Deborah J. Franklin -- 45.Vascular Diseases / Vincent J. Yacyshyn -- 46.Transplantation Medicine: A Rehabilitation Perspective / Michael Munin -- 47.Rehabilitation of the Individual with HIV / Steven M. Fine -- pt. IV Secondary Conditions and Complications -- 48.Physical Inactivity: Physiological and Functional Impairments and Their Treatment / Kathleen R. Bell -- 49.Treatment of the Patient with Chronic Pain / Maxim Eckmann -- 50.Spasticity and Muscle Overactivity as Components of the Upper Motor Neuron Syndrome / Neil N. Jasey, Jr. -- 51.Neurogenic Bladder and Bowel / Steven A. Steins -- 52.Pressure Ulcers / Kath Bogie -- pt. V Special Populations -- 53.Sports Medicine / Garrett S. Hyman -- 54.Physical Activity for People with Disabilities / Jennifer A. Gray-Stanley -- 55.Performing Arts Medicine / Katie Weatherhogg -- 56.Children with Disabilities / Michael Armento -- 57.Adults with Childhood-Onset Disabling Conditions / Dennis Matthews -- 58.Empowering Women with Disabilities to be Self-Determining in their Health Care / Cassing Hammond -- 59.Aging and Rehabilitation / Hilary C. Siebens -- 60.Primary Care for Persons with Disability / Amanda Harrington -- pt. VI Management Methods -- 61.Therapeutic Exercise / Daniel A. Judelson -- 62.Aquatic Rehabilitation / Andrew J. Cole -- 63.Therapeutic Physical Agents / G. David Baxter -- 64.Manipulation, Massage, and Traction / Gregory Thompson -- 65.Pharmacotherapy of Disability / Jiaxin J. Iran -- 66.The Pharmacology of Analgesic Agents / Antonio Hernandez -- 67.Injection Procedures / Maxim Eckmann -- 68.Spinal Injection Procedures / Evish Kamrava -- 69.Palliative Care Symptom Management / Andrea L. Cheville -- 70.Evolution of Biofeedback in Physical Medicine and Rehabilitation / He (Helen) Huang -- 71.Therapeutic Electrical Stimulation in Neurorehabilitation / John Chae -- 72.Functional Neuromuscular Electrical Stimulation / John Chae -- 73.Assistive Technology / Cathy Bodine -- 74.Upper and Lower Extremity Prosthetics / Daniel Santa Maria -- 75.Upper Limb Orthotics / Heikki Uustal -- 76.Lower Extremity Orthotics, Shoes, and Gait Aids / Alberto Esquenazi -- 77.Spinal Orthotics / Eva Durand -- 78.Wheelchairs / Rosemarie Cooper -- 79.Complementary and Alternative Medicine / David Jung Seto -- pt. VII Scientific Advances -- 80.Evidence-Based Practice in Rehabilitation (Including Clinical Trials) / Alan M. Jette -- 81.Neural Repair and Plasticity / Steven C. Cramer -- 82.Regenerative Medicine: Implications in Rehabilitation / Fabrisia Ambrosio -- 83.Rehabilitation Robotics / N. Hogan.

Introduction to the developing human -- The beginning of human development: first week -- Formation of bilaminar embryonic disc: second week -- Formation of germ layers and early tissue and organ differentiation: third week -- Organogenetic period: fourth to eighth weeks -- The fetal period: ninth week to birth -- the placenta and fetal membranes -- Body cavities, mesenteries, and diaphragm -- The pharyngeal apparatus -- The respiratory system -- The digestive system -- The urogenital system -- The cardiovascular system -- The skeletal system -- The muscular system -- The limbs -- The nervous system -- The eye and ear -- The integumentary system -- Congenital anatomical anomalies or human birth defects -- Common signaling pathways used during development.

The Cancer Genome -- Mechanisms of Genomic Instability -- Epigenetics of Cancer -- Telomeres, Telomerase, and Cancer -- Cell Signaling Growth Factors and Their Receptors -- Cell Cycle -- Mechanisms of Cell Death -- Cancer Metabolism -- Angiogenesis -- Invasion and Metastasis -- Cancer Stem Cells -- Biology of Personalized Cancer Medicine -- Tobacco -- Cancer Susceptibility Syndromes -- DNA Viruses -- RNA Viruses -- Inflammation -- Chemical Factors -- Physical Factors -- Dietary Factors -- Obesity and Physical Activity -- Epidemiologic Methods -- Global Cancer Incidence and Mortality -- Trends in Cancer Mortality -- Surgical Oncology: General Issues -- Surgical Oncology: Laparoscopic Surgery -- Radiation Oncology -- Medical Oncology -- Assessment of Clinical Response -- Cancer Immunotherapy -- Health Services Research and Economics of Cancer Care -- Pharmacokinetics and Pharmacodynamics -- Pharmacogenomics -- Alkylating Agents -- Platinum Analogs -- Antimetabolites -- Topoisomerase-Interacting Agents -- Antimicrotubule Agents -- Targeted Therapy with Small Molecule Kinase Inhibitors -- Histone Deacetylase Inhibitors and Demethylating Agents -- Proteasome Inhibitors -- Poly(ADP-Ribose) Polymerase Inhibitors -- Miscellaneous Chemotherapeutic Agents -- Interferons -- Interleukin Therapy -- Antisense Agents -- Antiangiogenesis Agents -- Monoclonal Antibodies -- Endocrine Manipulation -- Preventive Cancer Vaccines -- Tobacco Dependence and Its Treatment -- Role of Surgery in Cancer Prevention -- Principles of Cancer Risk Reduction Intervention -- Retinoids, Carotenoids, and Other Micronutrients in Cancer Prevention -- Drugs and Nutritional Extracts for Cancer Risk Reduction (Chemoprevention) -- Principles of Cancer Screening -- Early Detection Using Proteomics -- Screening for Gastrointestinal Cancers -- Screening for Gynecologic Cancers -- Screening for Breast Cancer -- Screening for Prostate Cancer -- Screening for Lung Cancer -- Genetic Counseling -- Vascular Access and Specialized Techniques -- Interventional Radiology -- Functional Imaging -- Molecular Imaging --Photodynamic Therapy -- Biomarkers -- Design and Analysis of Clinical Trials -- Molecular Biology of Head and Cancers -- Treatment of Head and Neck Cancer -- Rehabilitation after Treatment of Head and Neck Cancer -- Molecular Biology of Lung Cancer -- Non-Small Cell Lung Cancer -- Small Cell and Neuroendocrine Tumors of the Lung -- Neoplasms of the Mediastinum -- Molecular Biology of the Esophagus and Stomach -- Cancer of the Esophagus -- Cancer of the Stomach -- Molecular Biology of Pancreas Cancer -- Cancer of the Pancreas -- Molecular Biology of Liver Cancer -- Cancer of the Liver -- Cancer of the Biliary Tree -- Cancer of the Small Intestine -- Gastrointestinal Stromal Tumor -- Molecular Biology of Colorectal Cancer -- Cancer of the Colon -- Cancer of the Rectum -- Cancer of the Anal Region -- Molecular Biology of Kidney Cancer -- Cancer of the Kidney -- Molecular Biology of Bladder Cancer -- Cancer of the Bladder, Ureter, and Renal Pelvis -- Molecular Biology of Prostate Cancer -- Cancer of the Prostate -- Cancer of the Urethra and Penis -- Cancer of the Testis -- Molecular Biology of Gynecologic -- Cancer of the Cervix, Vagina, and Vulva -- Cancers of the Uterine Body -- Gestational Trophoblastic Neoplasms -- Ovarian Cancer, Fallopian Tube Carcinoma, and Peritoneal Carcinoma -- Molecular Biology of Breast Cancer -- Malignant Tumors of the Breast -- Molecular Biology of Endocrine Tumors -- Thyroid Tumors -- Parathyroid Tumors -- Adrenal Tumors -- Pancreatic Neuroendocrine Tumors -- Neuroendocrine (Carcinoid) Tumors and the Carcinoid Syndrome -- Multiple Endocrine Neoplasias -- Molecular Biology of Soft Tissue Sarcoma -- Soft Tissue Sarcoma -- Sarcomas of Bone -- Cancer of the Skin -- Molecular Biology of Cutaneous Melanoma -- Cutaneous Melanoma -- Molecular Biology of Central Nervous System Tumors -- Neoplasms of the Central Nervous System -- Molecular Biology of Childhood Cancers -- Solid Tumors of Childhood -- Leukemias and Lymphomas of Childhood -- Molecular Biology of Lymphomas -- Hodgkin Lymphoma -- Non-Hodgkin Lymphomas -- Cutaneous Lymphomas --Primary Central Nervous System Lymphoma -- Molecular Biology of Acute Leukemias -- Management of Acute Leukemias -- Molecular Biology of Chronic Leukemias -- Chronic Myelogenous Leukemia -- Chronic Lymphocytic Leukemias -- Myelodysplastic Syndromes -- Plasma Cell Neoplasms -- Cancer of Unknown Primary Site -- Benign and Malignant Mesothelioma -- Peritoneal Surface Malignancy -- Intraocular Melanoma -- AIDS-Related Malignancies -- Transplantation-Related Malignancies -- Superior Vena Cava Syndrome -- Increased Intracranial Pressure -- Spinal Cord Compression -- Metabolic Emergencies -- Metastatic Cancer to the Brain -- Metastatic Cancer to the Lung -- Metastatic Cancer to the Liver -- Metastatic Cancer to the Bone -- Malignant Effusions of the Pleura and the Pericardium -- Malignant Ascites -- Paraneoplastic Syndromes -- Autologous Stem Cell Transplantation -- Allogeneic Stem Cell Transplantation -- Infections in the Cancer Patient -- Leukopenia and Thrombocytopenia -- Cancer-Associated Thrombosis -- Nausea and Vomiting -- Diarrhea and Constipation -- Oral Complications -- Pulmonary Toxicity -- Cardiac Toxicity -- Hair Loss -- Gonadal Dysfunction -- Fatigue -- Second Primary Cancers -- Neurocognitive Effects -- Cancer Survivorship -- Management of Cancer Pain -- Nutritional Support -- Sexual Problems -- Psychological Issues in Cancer -- Communicating News to the Cancer Patient -- Specialized Care of the Terminally Ill -- Community Resources -- Rehabilitation of the Cancer Patient -- Regulatory Issues -- Health Disparities in Cancer -- Cancer Information on the Internet -- Complementary, Alternative, and Integrative Therapies in Cancer Care.

Clinical anatomy of the pelvis and reproductive tract / Alan Farthing -- Maternal physiology / Fiona Broughton-Pipkin -- The placenta and fetal membranes / Berthold Huppertz and John C.P. Kingdom -- Normal fetal growth / Jason Gardosi -- Pre-conception counselling / Andrew McCarthy -- Antenatal care / Timothy G. Overton -- Normal labour / A.A. Calder -- Fetal monitoring during labour / James A. Low -- Analgesia and anaesthesia / John A. Crowhurst -- Puerperium and lactation / D. Keith Edmonds -- Neonatal care for obstetricians / M.A. Thomson and A.D. Edwards -- Spontaneous miscarriage / Joanne Topping and Roy G. Farquarson -- Recurrent miscarriage / Raj Rai -- Ectopic pregnancy / Davor Jurkovic -- Trophoblast disease / Philip Savage and Michael Seckl -- Prenatal diagnosis and genetics / Sailesh Kumar -- Fetal medicine in clinical practice / R.C. Wimalasundera -- Obstetric emergencies / Sara Paterson-Brown -- Disorders of fetal growth and assessment of fetal well-being / G.C.S. Smith and C.C. Lees -- Multiple pregnancy / Nicholas M. Fisk -- Preterm labour / Philip Bennett -- Prolonged pregnancy / Patricia Crowley -- Induction and augmentation of labour / G. Justus Hofmeyr -- Malpresentation, malposition, cephalopelvic disproportion and obstetric procedures / S. Arulkumaran -- Hypertensive disorders / Andrew Shennan -- Heart disease in pregnancy / Catherine Nelson-Piercy -- Diabetes and endocrine disease in pregnancy / Anne Dornhorst and Catherine Williamson -- Renal disease / John Davison -- Haematological problems in pregnancy / P. Clark, A.J. Thomson and I.A. Greer -- Miscellaneous medical disorders / Andrew McCarthy -- Obstetric statistics / Jim G. Thornton -- Contraception / Anna Glasier -- Termination of pregnancy / Gillian Flett and Allen Templeton -- Normal and abnormal development of the genital tract / D. Keith Edmonds -- The menstrual cycle / William L. Ledger -- The role of ultrasound in gynaecology / Joanne Topping -- Gynaecological disorders of childhood and adolescence / D. Keith Edmonds -- Primary amenorrhoea / D. Keith Edmonds -- Polycystic ovarian syndrome and secondary amenorrhoea / Adam H. Balen -- Menstrual problems: menorrhagia and primary dysmenorrhoea / Margaret C.P. Rees -- Premenstrual syndrome / P.M.S. O'Brien -- Pelvic infection / Jonathan D.C. Ross and Peter Stewart -- Chronic pelvic pain / R. William Stones -- Endometriosis / Stephen Kennedy and Philippe Koninckx -- Infertility / Siladitya Bhattacharya -- Assisted reproduction / Geoffrey Trew -- Menopause and the postmenopausal woman / Nick Panay -- Pelvic floor dysfunction I: uterovaginal prolapse / Anthony R.B. Smith -- Urninary incontinence / D. Robinson and L. Cardozo -- Hysteroscopy and laparoscopy / Adam Magos -- Benign disease of the vulva / Richard Staughton -- Malignant disease of the vulva and vagina / David M. Luesley -- Benign diseases of the vagina, cervix and ovary / D. Keith Edmonds -- Premalignant and malignant disease of the cervix / Mahmood I. Shafi -- Epithelial ovarian cancer / Hani Gabra -- Benign disease of the uterus / Mary Ann Lumsden -- Cancer of the uterine corpus / Henry C. Kitchener -- Sexual dysfunction / Fran Reader -- Ethical dilemmas in obstetrics and gynaecology / Gordon M. Stirrat -- The law and the obstetrician and gynaecologist / Bertie Leigh -- Domestic violence and sexual assault / Maureen Dalton.

A synthesis of the best available evidence on diagnosis, management and treatment of frequent and high-cost problems occurring in primary care, inpatient and emergency department settings. Includes the top conditions; recommends a course of action for diagnosis, disease management and drug therapy.

A fully searchable, working editorial site of articles by scientists and scientific historians in the fields of biochemistry and physiology, cell biology, developmental biology, ecology, evolution, genetics, immunology, molecular biology, neuroscience, microbiology and virology, plant science, structural biology, and science and society.

V. 1 -- Endocrinology: impact on science and medicine -- Control of hormone gene expression -- Control of hormone secretion -- Insulin and growth factor signaling pathways -- Hormone signaling via G protein-coupled receptors -- Nuclear receptors: structure, function, and coregulators -- Applications of genetics in endocrinology -- Development of the pituitary -- Prolactin -- Adrenocorticotropic hormone -- Endocrine rhythms, the sleep-wake cycle, and biological clocks -- Hypothalamic syndromes -- Hypopituitarism and growth hormone deficiency -- Acromegaly -- Cushing's syndrome -- Clinically nonfunctioning sellar masses -- TSH-producing adenomas -- Disorders of prolactin secretion and prolactinomas -- Pituitary surgery -- Evaluation and management of childhood hypothalamic and pituitary tumors -- Vasopressin, diabetes insipidus, and the syndrome of inappropriate antidiuretic hormone secretion -- The pineal gland and melatonin -- Regulation of growth hormone and action (secretagogues) -- Insulin-like growth factor-1 and its binding proteins -- Somatic growth and maturation -- Growth hormone deficiency in children -- Appetite regulation and thermogenesis -- Obesity: the problem and its management -- Genetic syndromes associated with obesity -- Anorexia nervosa, bulimia nervosa, and other eating disorders -- Development of the endocrine pancreas -- Biosynthesis, processing, and secretion of the islet hormones: insulin, islet amyloid polypeptide (amylin), glucagon, somatostatin, and pancreatic polypeptide -- Insulin secretion -- The mechanisms of insulin action -- Glucagon and the glucagon-like peptides -- Regulation of intermediatory metabolism during fasting and feeding --Role of the adipocyte in metabolism and endocrine function -- Lipodystrophy syndromes -- Classification and diagnosis of diabetes mellitus -- Type 1 (insulin-dependent) diabetes mellitus: etiology, pathogenesis, prediction, and prevention -- Type 2 diabetes mellitus: etiology, pathogenesis, and natural history -- Lipoprotein metabolism and the treatment of lipid disorders -- Hyperglycemia secondary to nondiabetic conditions and therapies -- The metabolic syndrome -- Treatment of type 1 diabetes mellitus in adults -- Ketoacidosis and hyperosmolar coma -- Hypoglycemia and hypoglycemic syndromes -- Management of type 2 diabetes mellitus -- Management of diabetes mellitus in children -- Pancreatic and islet transplantation -- Diabetes control, long-term complications, and large vessel disease -- Diabetic eye disease -- Diabetes mellitus: neuropathy -- Diabetic nephropathy -- Diabetic foot and vascular complications -- Parathyroid hormone and parathyroid hormone-related peptide in the regulation of calcium homeostasis and bone development -- Calcitonin -- Vitamin D: from photosynthesis, metabolism, and action to clinical applications -- Bone development and remodeling -- Calcium regulation, calcium homeostasis, and genetic disorders of calcium metabolism -- Genetic disorders of phosphate homeostasis -- Primary hyperparathyroidism -- Malignancy-associated hypercalcemia and medical management -- Surgical management of hyperparathyroidism -- Pseudohypoparpathyroidism, Albright's hereditary osteodystrophy, and progressive osseous heteroplasia: disorders caused by inactivating GNAS mutations -- Genetic defects in vitamin D metabolism and action -- Hereditary disorders of the skeleton -- Bone density and imaging of osteoporosis -- Chronic kidney disease mineral and bone disorder -- Disorders of calcification: osteomalacia and rickets -- Paget's disease of bone --V. 2 -- Anatomy and development of the thyroid -- Thyroid-stimulating hormone: physiology and secretion -- Thyroid regulatory factors -- Thyroid hormone metabolism -- Mechanisms of thyroid hormone action -- Thyroid function testing -- Thyroid imaging -- Autoimmune thyroid disease -- Graves' disease -- Graves' ophthalmopathy -- Autonomously functioning thyroid nodules and other causes of thyrotoxicosis -- Chronic (Hashimoto's) thyroiditis -- Subacute and Riedel's thyroiditis -- Hypothyroidism and myxedema coma -- Nonthyroidal illness syndrome: a form of hypothyroidism -- Multinodular goiter -- Iodine deficiency disorders -- Thyroid neoplasia -- Medullary thyroid carcinoma and multiple endocrine neoplasia type 2 -- Thyroid-stimulating hormone receptor mutations -- Genetic defects in thyroid hormone synthesis and action -- Thyroid hormone binding and variants of transport proteins -- Resistance to thyroid hormone -- Surgery of the thyroid -- The principles, enzymes, and pathways of human steroidogenesis -- Glucocorticoid action: physiology -- Glucocorticoid receptors: their mechanisms of action and glucocorticoid resistance -- Aldosterone: secretion and action -- Glucocorticoid therapy -- Adrenal insufficiency -- Adrenal causes of hypercortisolism -- Defects of adrenal steroidogenesis -- Adrenarche and adrenopause -- Adrenal gland imaging -- Adrenocortical carcinoma -- Primary mineralocorticoid excess syndromes and hypertension -- Mineralocorticoid deficiency -- Pheochromocytoma -- Adrenal surgery --Hormones of the cardiovascular system -- Hyponatremia and hypernatremia -- Orthostatic hypotension and orthostatic intolerance -- Endocrine aspects of critical care medicine -- Gonadotropin-releasing hormones -- Gonadal peptides: inhibins, activins, follistatin, Müllerian-inhibiting substance (antimüllerian hormone) -- Gonadotropins-regulation of synthesis and secretion -- Genetic basis of gonadal and genital development -- Diagnosis and treatment of disorders of sexual development -- Endocrinology of sexual maturation and puberty -- Precocious puberty -- Delayed puberty -- Hormonal control of breast development -- The endocrinology of sexual behavior and gender identity -- Folliculogenesis, ovulation, and luteogenesis -- Ovarian hormone synthesis -- Estrogen and progesterone action -- Hormonal regulation of the menstrual cycle, mechanisms of ovulation, premenstrual syndromes -- Amenorrhea, anovulation, and dysfunctional uterine bleeding -- Endometriosis -- Female subfertility: evaluation and management -- Hyperandrogenism, hirsutism, and the polycystic ovary syndrome -- Ovulation induction and assisted reproduction -- Contraception -- Menopause -- Functional morphology of the testis -- Androgen physiology, pharmacology, and abuse -- Testicular dysgenesis syndrome, cryptorchidism, hypospadias, and testicular tumors -- Androgen deficiency disorders -- Gynecomastia -- Clinical management of male infertility -- Male contraception -- Endocrinology of the prostate -- The endocrinology of human pregnancy and parturition -- Fetal and neonatal endocrinology -- Diabetes mellitus and pregnancy -- Diagnosis and treatment of thyroid disease during pregnancy -- Hormonal changes and endocrine testing in pregnancy -- Autoimmune polyglandular syndromes -- Multiple endocrine neoplasia type 1 -- Multiple endocrine neoplasia type 2 -- Gastrointestinal hormones and tumor syndromes -- Carcinoid syndrome -- Ectopic hormone syndromes -- Endocrine testing.

Why learn methods in infectious disease epidemiology? -- Why study methods? -- Descriptive infectious disease epidemiology -- Outbreak investigations -- Rates and measures -- Laying the foundation: how to conduct a study -- Experimental designs as a foundation for observational studies -- Cohort studies -- Case-control and cross-sectional studies -- Interpretation of epidemiologic data -- Threats to internal and external validity of concern in the study of infectious disease epidemiology -- Surveillance of infectious diseases -- Program evaluation in the infectious disease setting.

Cervical spondylotic myelopathy -- Cervical facet arthropathy -- Cervical degenerative disease -- Cervical radiculopathy -- Cervical sprain or strain -- Cervical stenosis -- Cervicogenic vertigo -- Trapezius strain -- Acromioclavicular injuries -- Adhesive capsulitis -- Biceps tendinitis -- Biceps tendon rupture -- Glenohumeral instability -- Rotator cuff tendinitis -- Rotator cuff tear -- Scapular winging -- Shoulder arthritis -- Elbow arthritis -- Epicondylitis -- Median neuropathy -- Olecranon bursitis -- Radial neuropathy --Ulnar neuropathy (elbow) -- de quervain tenosynovits -- Dupuytren contracture -- Extensor tendon injuries -- Flexor tendon injuries -- Hand and wrist ganglia -- Hand osteoarthritis -- Kienböck disease -- Median neuropathy (carpal tunnel syndrome) -- Trigger finger -- Ulnar collateral ligament sprain -- Ulnar neuropathy (wrist) -- Wrist osteoarthritis -- Wrist rheumatoid arthritis -- Thoracic compression fracture -- Thoracic radiculopathy -- Thoracic sprain or strain -- Lumbar degenerative disease -- Lumbar facet arthropathy -- Lumbar radiculopathy -- Low back strain or sprain -- Lumbar spondylolysis and spondylolisthesis -- Lumbar spinal stenosis -- Sacroiliac joint dysfunction -- Hip osteoarthritis -- Femoral neuropathy -- Lateral femoral cutaneous neuropathy -- Piriformis syndrome -- Quadriceps contusion -- Total hip replacement -- Trochanteric bursitis -- Anterior cruciate ligament tear -- Baker's cyst -- Collateral ligament sprain -- Compartment syndrome -- Hamstring strain -- Iliotibial band syndrome -- Knee osteoarthritis -- Knee bursitis -- Meniscal injuries -- Jumper's knee -- Patellofemoral syndrome -- Peroneal neuropathy -- Posterior cruciate ligament sprain -- Quadriceps tendinitis -- Shin splints -- Stress fractures -- Total knee replacement -- Achilles tendinitis -- Ankle arthritis -- Foot and ankle bursitis -- Ankle sprain -- Bunion and bunionette --Chronic ankle instability -- Claw toe -- Corns -- Foot and ankle ganglia -- Hallux rigidus -- Hammer toe -- Mallet toe -- Metatarsalgia -- Morton neuroma -- Plantar fasciitis -- Posterior tibial tendon dysfunction -- Tibial neuropathy (tarsal tunnel syndrome) -- Occipital neuralgia -- Trigeminal neuralgia -- Thoracic outlet syndrome -- Chronic pain syndrome -- Complex regional pain syndrome -- Headaches -- Fibromyalgia -- Myofascial pain syndrome -- Repetitive strain injuries -- Costosternal syndromes -- Intercostal neuralgia -- Tietze syndrome -- Postherpetic neuralgia -- Arachnoiditis -- Coccydynia -- Phantom limb pain -- Cervical dystonia -- Post-thoracotomy pain syndrome -- Post-mastectomy pain syndrome -- Upper limb amputations -- Lower limb amputations -- Ankylosing spondylitis -- Burns -- Cardiac rehabilitation -- Cancer -- Cerebral palsy -- Chronic fatigue syndrome -- Chronic kidney disease -- Joint contractures -- Deep venous thrombosis -- Dementia -- Management of the patient with a foot at risk: peripheral arterial disease and diabetes -- Dysphagia -- Enteropathic arthritides -- Heterotopic ossification -- Lymphedema -- Motor neuron disease -- Movement disorders -- Multiple sclerosis -- Myopathies -- Neurogenic bladder -- Osteoarthritis -- Osteoporosis -- Parkinson disease -- Peripheral neuropathies -- Plexopathy-brachial -- Plexopathy-lumbosaral -- Polytrauma rehabilitation -- Post-poliomyelitis syndrome -- Post-concussion disorders -- Psoriatic arthritis -- Pressure ulcers -- Pulmonary rehabilitation -- Rheumatoid arthritis -- Scoliosis and kyphosis -- Spasticity -- Speech and language disorders -- Spinal cord injury (cervical) -- Spinal cord injury (thoracic) -- Spinal cord injury (lumbosacral) -- Stroke -- Stroke in young adults -- Systemic lupus erythematosus -- Transverse myelitis -- Traumatic brain injury.

Examination preparation and subject review for USMLE Step 1 (9000+ questions), USMLE Step 2 (5000+ questions), and USMLE Step 3 (3000+ questions), among others. Certification Review aids cover Family Practice, General Pediatrics, General Surgery, Internal Medicine, Obstetrics and Gynecology, and SPEX. Students can create self-study exams in a variety of subjects.

Volume 1 -- Section 1. The Field of Neonatal-Perinatal Medicine -- Section 2. The Fetus -- Section 3. Pregnancy Disorders and Their Impact on the Fetus -- Section 4. The Delivery Room -- Section 5. Provisions for Neonatal Care -- Volume 2 -- Section 6. Development and Disorders of Organ Systems.

Sect. 1: Disorders of sebaceous and apocrine glands -- Sect. 2: Eczema/dermatitis -- Sect. 3: Psoriasis -- Sect. 4: Ichthyoses -- Sect. 5: Miscellaneous epidermal disorders -- Sect. 6: Bullous diseases -- Sect. 7: Miscellaneous inflammatory disorders -- Sect. 8: Severe and life-threatening eruptions in the acutely ill patient -- Sect. 9: Benign neoplasms and hyperplasias -- Sect. 10: Photosensitivity, photo-induced disorders, and disorders by ionizing radiation -- Sect. 11: Precancerous lesions and cutaneous carcinomas -- Sect. 12: Melanoma precursors and primary cutaneous melanoma -- Sect. 13: Pigmentary disorders -- Sect. 14: The skin signs in immune, autoimmune, and rheumatic disorders -- Sect. 15: Endocrine, metabolic, nutritional, and genetic diseases -- Sect. 16: Skin signs or vascular insufficiency -- Sect. 17: Skin signs of renal insufficiency -- Sect. 18: Skin signs of systemic cancers -- Sect. 19: Skin signs of hematologic disease -- Sect. 20: Cutaneous lymphomas and sarcoma -- Sect. 21: Skin diseases in organ and bone marrow transplantation -- Sect. 22: Adverse cutaneous drug reactions -- Sect. 23: Disorders of psychiatric etiology -- Sect. 24: Bacterial infections involving the skin -- Sect. 25: Fungal infections of the skin and hair -- Sect. 26: Rickettsial infections -- Sect. 27: Viral infections of skin and mucosa -- Sect. 28: Arthropod insect bites, stings, and cutaneous infections -- Sect. 29: Systemic parasitic infections -- Sect. 30: Sexually transmitted infections -- Sect. 31: Human retroviral infections and mucocutaneous manifestations of HIV/AIDS disease -- Sect. 32: Disorders of hair follicles and related disorders -- Sect. 33: Disorders of the nail apparatus -- Sect. 34: Disorders of the mouth -- Sect. 35: Disorders of the genitalia, perineum, and anus -- Sect. 36: Generalized pruritus without skin lesions.

Adrenal glands and kidneys / William E. Brant -- Pelvicaliceal system, ureters, bladder, and urethra / William E. Brant -- Genital tract: radiographic imaging and MR / William E. Brant -- Abdomen ultrasound / William E. Brant -- Genital tract and bladder ultrasound / William E. Brant -- Obstetric ultrasound / William E. Brant -- Chest, thyroid, parathyroid, and neonatal brain ultrasound / William E. Brant -- Vascular ultrasound / Raymond S. Dougherty, William E. Brant -- Benign cystic bone lesions / Clyde A. Helms -- Malignant bone and soft tissue tumors / Clyde A. Helms -- Skeletal trauma / Clyde A. Helms -- Arthritis / Clyde A. Helms -- Metabolic bone disease / Clyde A. Helms -- Skeletal "don't touch" lesions / Clyde A. Helms -- Miscellaneous bone lesions / Clyde A. Helms -- Magnetic resonance imaging of the knees / Clyde A. Helms -- Magnetic resonance imaging of the shoulder / Clyde A. Helms -- Magnetic resonance imaging of the foot and ankle / Clyde A. Helms -- Pediatric chest / Susan D. John, Leonard E. Swischuk -- Pediatric abdomen and pelvis / Susan D. John, Leonard E. Swischuk -- Introduction to nuclear medicine / David K. Shelton -- Essential science of nuclear medicine / Ramsey D. Badawi, Linda A. Kroger, Jerrold T. Bushberg -- Skeletal system scintigraphy / David K. Shelton, Michael F. Hartshorne -- Pulmonary scintigraphy / David K. Shelton, Rhonda A. Wyatt -- Cardiovascular system scintigraphy / David K. Shelton, Michael F. Hartshorne -- Endocrine gland scintigraphy / Marc G. Cote -- Gastrointestinal, liver/spleen, and hepatobiliary scintigraphy / David K. Shelton, Michael F. Hartshorne -- Genitourinary system scintigraphy / Mike McBiles, Peter W. Blue -- Scintigraphic diagnosis of inflammation and infection / Christopher J. Palestro, Charito Love -- Molecular imaging of tumors / James H. Timmons -- Central nervous system scintigraphy / David H. Lewis, Vivek Manchanda -- Positron emission tomography and PET-PC / Bijan Bijan, David K. Shelton, William E. Brant.Diagnostic imaging methods / William E. Brant -- Introduction to brain imaging / David J. Seidenwurm -- Craniofacial trauma / Robert M. Barr, Alisa D. Gean, Tuong H. Le -- Cerebrovascular disease / Howard A. Rowley -- Central nervous system neoplasms and tumorlike masses / Kelly K. Koeller -- Central nervous system infections / Walter L. Olsen -- White matter and neurodegenerative diseases / Jerome A. Barakos -- Pediatric neuroimaging / Todd E. Lempert, Erik H.L. Gaensler -- Head and neck imaging / Jerome A. Barakos -- Nondegenerative diseases of the spine / Erik H.L. Gaensler -- Lumbar spine: disk disease and stenosis / Clyde A. Helms -- Methods of examination, normal anatomy, and radiographic findings of chest disease / Santiago Miró, Jeffrey S. Klein -- Mediastinum and hila / Jeffrey S. Klein -- Pulmonary vascular disease / Jeffrey S. Klein -- Pulmonary neoplasms / Jeffrey S. Klein -- Pulmonary infection / Timothy J. Higgins, Jeffrey S. Klein -- Diffuse lung disease / Jeffrey S. Klein -- Airways disease / Jeffrey S. Klein -- Pleura, chest wall, diaphragm, and miscellaneous chest disorders / Jeffrey S. Klein -- Breast imaging / Karen K. Lindfors, Huong T. Le-Petross -- Cardiac anatomy, physiology, and imaging methods / David K. Shelton -- Cardiac imaging in acquired disease / David K. Shelton -- Cardiac mri / Christopher M. Kramer -- Thoracic aorta, pulmonary arteries, and peripheral vascular disorders / Michael J. Miller, Jr., Tony P. Smith -- Abdominal arteries, venous system, and nonvascular intervention / Michael J. Miller, Jr., Tony P. Smith -- Abdomen and pelvis / William E. Brant -- Liver, biliary tree, and gallbladder / William E. Brant -- Pancreas and spleen / William E. Brant -- Pharynx and esophagus / William E. Brant -- Stomach and duodenum / William E. Brant -- Mesenteric small bowel / William E. Brant -- Colon and appendix / William E. Brant--

General features of the gastrointestinal tract and evaluation of specimens derived from it -- The nonneoplastic esophagus -- The neoplastic esophagus -- The nonneoplastic stomach -- The neoplastic stomach -- The nonneoplastic small intestine -- Epithelial tumors of the small intestine -- Nonneoplastic diseases of the appendix -- The neoplastic appendix -- Motility disorders -- Inflammatory bowel disease -- Polyposis and hereditary cancer syndromes -- The nonneoplastic colon -- Epithelial neoplasms of the colon -- The nonneoplastic anus -- Neoplastic lesions of the anus -- Gastrointestinal neuroendocrine lesions -- Lymphoproliferative disorders of the gastrointestinal tract -- Mesenchymal tumors.

Social and ethical issues in medicine -- Principles of evaluation and management -- Preventive and environmental issues -- Aging and geriatric medicine -- Clinical pharmacology -- Genetics -- Principles of immunology and inflammation -- Cardiovascular disease -- Respiratory diseases -- Critical care medicine -- Renal and genitourinary diseases -- Gastrointestinal diseases -- Diseases of the liver, gallbladder, and bile ducts -- Hematologic diseases -- Oncology -- Metabolic diseases -- Nutritional diseases -- Endocrine diseases -- Women's health -- Diseases of bone and mineral metabolism -- Diseases of allergy and clinical immunology -- Rheumatic diseases -- Infectious diseases -- HIV and the acquired immunodeficiency syndrome -- Neurology -- Eye, ear, nose, and throat diseases -- Medical consultation -- Skin diseases.

Drug invention and the pharmaceutical industry -- Pharmacokinetics: the dynamics of drug absorption, distribution, metabolism, and elimination -- Pharmacodynamics: molecular mechanisms of drug action -- Drug toxicity and poisoning -- Membrane transporters and drug response -- Drug metabolism -- Pharmacogenetics -- Neurotransmission: the autonomic and somatic motor nervous systems -- Muscarinic receptor agonists and antagonists -- Anticholinesterase agents -- Agents acting at the neuromuscular junction and autonomic ganglia -- Adrenergic agonists and antagonists -- 5-Hydroxytryptamine (serotonin) and dopamine -- Neurotransmission and the central nervous system -- Drug therapy of depression and anxiety disorders -- Pharmacotherapy of psychosis and mania -- Hyponotics and sedatives -- -- Opioids, analgesia, and pain management -- General anesthetics and therapeutic gases -- Local anesthetics -- Pharmacotherapy of the epilepsies -- Treatment of central nervous system degenerative disorders -- Ethanol and methanol -- Drug addiction -- Regulation of renal function and vascular volume -- Renin and angiotensin -- Treatment of myocardial ischemia and hypertension -- Pharmacotherapy of congestive heart failure -- Anti-arrhythmic drugs -- Blood coagulation and anticoagulant, fibrinolytic, and antiplatelet drugs -- Drug therapy for hypercholesterolemia and dyslipidemia -- Histamine, bradykinin, and their antagonists -- Lipid-derived autacoids: eicosanoids and platelet-activating factor -- Anti-inflammatory, antipyretic, and analgesic agents; pharmacotherapy of gout -- Immunosuppressants, tolerogens, and immunostimulants -- Pulmonary pharmacology -- Hematopoietic agents: growth factors, minerals, and vitamins --Introduction to endocrinology: the hypothalamic-pituitary axis -- Thyroid and anti-thyroid drugs -- Estrogens and progestins -- Androgens -- ACTH, adrenal steroids, and pharmacology of the adrenal cortex -- Endocrine pancreas and pharmacotherapy of diabetes mellitus and hypoglycemia -- Agents affecting mineral ion homeostasis and bone turnover -- Pharmacotherapy of gastric acidity, peptic ulcers, and gastroesophageal reflux disease -- Treatment of disorders of bowel motility and water flux; anti-emetics; agents used in biliary and pancreatic disease -- Pharmacotherapy of inflammatory bowel disease -- General principles of antimicrobial therapy -- Chemotherapy of malaria -- Chemotherapy of protozoal infections: amebiasis, giardiasis, trichomoniasis, trypanosomiasis, leishmaniasis, and other protozoal infections -- Chemotherapy of helminth infections -- Sulfonamides, trimethoprim-sulfamethoxazole, quinolones, and agents for urinary tract infections -- Penicillins, cephalosporins, and other β-lactam antibiotics -- Aminoglycosides -- Protein synthesis inhibitors and miscellaneous antibacterial agents -- Chemotherapy of tuberculosis, mycobacterium avium complex disease, and leprosy -- Antifungal agents -- Antiviral agents (nonretroviral) -- Antiretroviral agents and treatment of HIV infection -- General principles of cancer chemotherapy -- Cytotoxic agents -- Targeted therapies: tyrosine kinase inhibitors, monoclonal antibodies, and cytokines -- Natural products in cancer chemotherapy: hormones and related agents -- Ocular pharmacology -- Dermatological pharmacology -- Contraception and pharmacotherapy of obstetrical and gynecological disorders -- Environmental toxicology; carcinogens and heavy metals -- Appendix I: Principles of prescription order writing and patient compliance -- Appendix II: Design and optimization of dosage regimens: pharmacokinetic data.

Thorax -- Abdomen -- Pelvis and perineum -- Back -- Lower limb -- Upper limb -- Head -- Neck -- Cranial nerves.

The back -- The upper limb -- The thorax -- The abdomen -- The pelvis and perineum -- The lower limb -- The head and neck.

"The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images"--Provided by publisher.

This textbook covers the essentials of human physiology and aims to describe complex physiologic principles in language that is easy to read and understand. The content is arranged in 14 units and 84 chapters. It includes new illustrations in color.

Part I: Evaluating the patient before anesthesia --Evaluating the patient before anesthesia /Alla Tauber and Mary Kraft --Specific considerations with cardiac disease /Shahzad Shaefi and Hovig V. Chitilian --Specific considerations with pulmonary disease /Stephanie C. Cintora and Kenneth E. Shepherd --Specific considerations with renal disease /Rafael Vazquez and William Benedetto --Specific considerations with liver disease /Salomon M. Maya and Wilton C. Levine --Specific considerations with endocrine disease /Anne M. Drewry, Robert A. Peterfreund, and Stephanie L. Lee --Infectious diseases and infection control in anesthesia /Shahzad Shaefi and Ulrich Schmidt --Part II: Administration of anesthesia --Safety in anesthesia /Sara N. Goldhaber-Fiebert and Jeffrey B. Cooper --The anesthesia machine /Andrew R. Vaclavik and Greg Ginsburg --Monitoring /Jennifer Chatburn and Warren S. Sandberg --Intravenous and inhalation anesthetics /Claudia Benkwitz and Ken Solt --Neuromuscular blockade /Oleg V. Evgenov and Peter F. Dunn --Airway evaluation and management /Cosmin Gauran and Peter F. Dunn --Administration of general anesthesia /Victor A. Chin and Stuart A. Forman --Local anesthetics /Maryam Jowza and Rebecca D. Minehart --Spinal, epidural, and caudal anesthesia /Jason M. Lewis and May C. M. Pian-Smith --Regional anesthesia /Keith Fragoza and Lisa Warren --Intra-anesthetic problems /Jonathan D. Bloom and Keith Baker --Perioperative hemodynamic control /Brian T. Bateman and Vilma E. Ortiz --Anesthesia for abdominal surgery /Emily A. Singer and John J. A. Marota --Anesthesia for thoracic surgery /Junichi Naganuma and Paul H. Alfille --Anesthesia for vascular surgery /M. Richard Pavao and Edward A. Bittner --Anesthesia for cardiac surgery /Ethan Small and Jason Zhensheng Qu --Anesthesia for neurosurgery /Scott A. LeGrand and Michele Szabo --Anesthesia for head and neck surgery /Brian D. Cauley and Deborah S. Pederson --Anesthesia for urologic surgery /Kris C. Lukauskis and William R. Kimball --Anesthesia for geriatric patients /Zhongcong Xie and Christine Finer --Anesthesia for surgical emergencies in the neonate /James Y. Ko ... [et al.] --Anesthesia for pediatric surgery /Susan A. Vassallo and LIsbeth L. Pappas --Anesthesia for obstetrics and gynecology /Amy Ortman and Lisa Leffert --Ambulatory anesthesia /Christopher J. Hodge and LIsa Wollman --Anesthesia outside of the operating room /Thomas J. Graetz and John J. A. Marota --Anesthesia for trauma and burns /Vikram Kumar and Keith Baker --Transfusion therapy /Shubha V. Y. Raju and Jonathan E. Charnin --Part III: Perioperative issues --The postanesthesia care unit /Asheesh Kumar and Edward E. George --Perioperative respiratory failure /Michael R. Shaughnessy and Luca M. Bigatello --Adult, pediatric, and newborn resuscitation /Richard M. Pino, Bradley E. Randel, and Arthur J. Tokarcyzk --Pain /Karsten Bartels and James P. Rathmell --Complementary and alternative medicine /Margaret A. Gargarian and P. Grace Harrell --Ethical and end-of-life issues /Sheri Berg and Rae M. Allain --Appendix A: supplemental drug information /Bishr Haydar.

Genetics of eye disease / Terri L. Young and Leila M. Khazaeni -- Neonatal ophthalmology: ocular development in childhood / Kammi B. Gunton, Leonard B. Nelson, and Scott E. Olitsky -- Retinopathy of prematurity / James D. Reynolds -- The pediatric eye examination / John W. Simon and Nalini K. Aggarwal -- Electrodiagnostic tests of the retina and higher centers / Ronald E. Carr -- Refraction in infants and children / Michael X. Repka -- Ambylopia / Evelyn A. Paysse and David K. Coats -- Sensory adaptations in strabismus / Marshall M. Parks -- Strabismus disorders / Scott E. Olitsky and Leonard B. Nelson -- Surgical management of strabismus / Rudolph S. Wagner -- Conjunctival diseases / Cintia F. Gomi ... [et al.] -- Diseases of the cornea / Christopher J. Rapuano and Peter R. Laibson -- Pediatric cataracts and lens anomalies / Derek B. Hess, Rachel A. Tesser, and Edward G. Buckley -- Glaucoma in infants and children / Sharon F. Freedman and David S. Walton -- Uveitis in children / Conrad L. Giles, Antonio Capone Jr., and Mandar M. Joshi -- Diseases of the retina and vitreous / Eric D. Weichel ... [et al.] -- Congenital abnormalities of the optic disc / Gary C. Brown and Melissa M. Brown -- Disorders of the lacrimal apparatus in infancy and childhood / Deborah K. VanderVeen -- Pediatric eyelid disorders / Forrest J. Ellis -- Disorders of the orbit / Daniel P. Schaefer -- Ocular tumors of childhood / Jerry A. Shields and Carol L. Shields -- The systemic hamartomatoses ("phakomatoses") / Jerry A. Shields and Carol L. Shields -- Ocular abnormalities in childhood metabolic disorders / Avery H. Weiss -- Pediatric neuro-ophthalmology / Robert C. Sergott and Denise Hug -- Nystagmus / Mitchell B. Strominger -- Ocular trauma and its prevention / Robert A. Catalano -- Role of the ophthalmologist in learning disorders / Harold P. Koller and Kenneth B. Goldberg -- Working with visually impaired children and their families / Marilyn A. Moller with Rose D. Skolnick -- Medicolegal issues in pediatric ophthalmology / Edward L. Raab -- The evolution of strabismus surgery / Norman B. Medow.

Includes the complete contents of the latest online version of Harrison's Principles of internal medicine as well as updates and links to related material.

Introduction to clinical medicine -- Cardinal manifestations and presentation of diseases -- Genetics and disease -- Regenerative medicine -- Nutrition -- Oncology and hematology -- Infectious diseases -- Bioterrorism and clinical medicine -- Disorders of the cardiovascular system -- Disorders of the respiratory system -- Critical care medicine -- Disorders of the kidney and urinary tract -- Disorders of the gastrointestinal system -- Disorders of the immune system, connective tissue, and joints -- Endocrinology and metabolism -- Neurologic disorders -- Poisoning, drug overdose, and envenomation -- E-chapters from international advisory editors.

Introduction to clinical medicine -- Cardinal manifestations and presentation of diseases -- Genes, the environment, and disease -- Regenerative medicine -- Aging -- Nutrition -- Oncology and hematology -- Infectious diseases -- Terrorism and clinical medicine -- Disorders of the cardiovascular system -- Disorders of the respiratory system -- Critical care medicine -- Disorders of the kidney and urinary tract -- Disorders of the gastrointestinal system -- Disorders of the joints and adjacent tissues -- Endocrinology and metabolism -- Neurologic disorders -- Poisoning, drug overdose, and envenomation -- High-altitude and decompression sickness.

Biology of aging and longevity -- Genetics of age-dependent human disease -- Immunology and aging -- Inflammation and aging -- Demography and epidemiology -- International gerontology -- Psychosocial aspects of aging -- General principles of pharmacology -- Preventive gerontology: strategies for optimizing health across the life span -- Evaluation, management, and decision making with the older patient -- Principles of geriatric assessment -- Mental status and neurological examination in older adults -- Assessment of decisional capacity and competencies -- Principles of screening in older adults -- Health care system -- Transitions -- Acute hospital care -- Emergency department care -- Critical care -- Subacute care -- Nursing facility care -- Community-based long-term care and home care -- Rural aging -- Appropriate approach to prescribing -- Complementary and alernative medicine -- Team care -- Social work -- Self-management of health behavior in geriatric medicine -- Rehabilitation -- Pain management -- Palliative care -- Legal issues -- Spirituality -- Ethical issues -- Perioperative evaluation and management -- Anesthesia -- Surgical outcomes -- Nutrition and aging -- Weight and age: paradoxes and conundrums -- Malnutrition and enteral/parenteral alimentation -- Disorders of swallowing -- Oral cavity -- Assessment and rehabilitation of older adults with low vision -- Age-related changes in the auditory system -- Sex and gender across the human life span -- Menopause and midlife health changes -- Sexuality, sexual function, and the aging woman -- Gynecologic disorders -- Sexuality, sexual function, androgen therapy, and the aging male -- Benign prostate disorders -- Aging and homeostatic regulation -- Frailty -- Delirium -- Falls -- Sleep disorders -- Dizziness -- Syncope -- Pressure ulcers -- Incontinence -- Elder mistreatment -- Cellular and neurochemical aspects of the aging human brain -- Cognitive changes associated with normal and pathological aging -- Psychoactive drug therapy -- Cerebrovascular disease -- Dementia including Alzheimer's disease --Parkinson's disease and related disorders -- Other neurodegenerative disorders -- Traumatic brain injury -- Epilepsy -- Late-life mood disorders -- Schizophrenia -- General topics in geriatric psychiatry -- Management of agitation in dementia -- Effects of aging on cardiovascular structure and function -- Aging and atherosclerosis -- Coronary heart disease -- Valvular heart disease -- Heart failure -- Cardiac arrhythmias -- Peripheral vascular disease -- Hypertension -- Aging of the respiratory system -- Chronic obstructive pulmonary disease -- Diffuse parenchymal lung disease -- Changes in kidney function -- Renal disease -- End-stage renal disease -- Disorders of fluid balance -- Effect of aging on gastrointestinal function -- Hepatic, biliary, and pancreatic disease -- Upper gastrointestinal disorders -- Common large intestinal disorders -- Constipation -- Oncology and aging: general principles -- Breast disease -- Prostate cancer -- Lung cancer -- Gastrointestinal malignancies -- Intracranial neoplasms -- Skin cancer -- Aging of the hematopoietic system -- Anemia -- White cell disorders -- Non-Hodgkin's and Hodgkin's lymphomas and myeloma -- Thrombosis -- Hemorrhagic disorders -- Aging of the endocrine system and selected endocrine disorders -- Thyroid diseases -- Diabetes mellitus -- Dyslipoproteinemia -- Hyperparathyroidism and Paget's disease of bone -- Aging of the muscles and joints -- Biomechanics of mobility -- Exercise: physiologic and functional effects -- Mobility -- Osteoarthritis -- Osteoporosis -- Hip fractures -- Myopathy, polymyalgia rheumatica, and temporal arteritis -- Rheumatoid arthritis and other autoimmune diseases -- Back pain and spinal stenosis -- Primary considerations in managing the older patient with foot problems -- Fibromyalgia and myofascial pain syndromes -- Infection in the elderly -- General principles of antimicrobial selection -- Pneumonia -- Urinary tract infections -- Human immunodeficiency virus infection -- Herpes zoster -- Influenza and respiratory syncytial virus.

General principles of management of head and neck cancer --General principles of head and neck pathology /Bruce M. Wenig and Jean-Marc Cohen --Prognostic factors in patients with head and neck cancer /Benjamin D. Smith and Bruce G. Haffty --General clinical evaluation of the head and neck patient /Douglas K. Frank and Roy B. Sessions --Special radiologic imaging considerations in the evaluation of squamous cell cancer of the head and neck /Suresh K. Mukherji --Novel radiation therapy techniques in the management of head and neck cancer /Avraham Eisbruch --Dental oncology and maxillofacial prosthetics /Jack W. Martin, James C. Lemon, and Mark C. Chambers --Total supportive care: nutrition, symptom management, pain, and psychosocial support /Elise Carper, Stewart B. Fleishman, and David Seres --General principles of rehabilitation of speech, voice, and swallowing function after treatment of head and neck cancer /Jan S. Lewin and Katherine A. Hutcheson --Site-specific principles of management of head and neck cancer --Management of the Neck-Surgery --Management of the neck: radiation therapy and chemotherapy /Kenneth S. Hu, Harry Quon, and Louis B. Harrison --Metastatic cancer to the neck from an unknown primary site --Cancer of the oral cavity --Cancer of the oropharynx --Early-stage cancer of the larynx --Advanced stage cancer of the larynx --Cancer of the hypopharynx and cervical esophagus --Cancer of the nasal vestibule, nasal cavity, and paranasal sinus: surgical management /Mark S. Persky and Abtin Tabaee --Cancer of the nasal cavity and paranasal sinus: radiation therapy and chemotherapy management --Cancer of the nasopharynx --Basal and squamous cell skin cancers --Melanoma of the head and neck --Malignant salivary gland tumors --Cancers involving the skull base and temporal bone /Ivo P. Janecka, et. al. --Pargangliomas of the head and neck --Cancer of the thyroid and parathyroid --Soft tissue and bone sarcomas of the head and neck --Cancer of the orbit: surgical management --Cancer of the orbit and ocular structures: radiation therapy and management /Jorge E. Freire, et.al. --Systemic targeted therapy for recurrent and metastatic head and neck cancer /Syed M. Ahmed, Victoria Villaflor, and Ezra E. W. Cohen --Basic science and epidemiology of head and neck cancer --Molecular biology of head and neck cancer /Patrick K. Ha, Joseph A. Califano, and David Sidransky --Molecular and genetic predisposition for the squamous cell carcinoma of the head and neck /Qingyi Wei, Kathryn L. Patterson, Erich M. Sturgis, and Margaret R. Spitz --Angiogenesis and metastases in head and neck cancer /Chad E. Galer and Jeffrey N. Myers --Human papillomavirus and prevention and therapy of head and neck cancer /Maura L. Gillison --Chemoprevention of head and neck cancer /Anne Tsao and Vassiliki A. Papadimitrakopoulou.

Section 1. Basic Mechanisms of Heart Failure -- Section 2. Mechanisms of Disease Progression in Heart Failure -- Section 3. Etiological Basis for Heart Failure -- Section 4. Clinical Assessment of Heart Failure -- Section 5. Therapy for Heart Failure.

Blood platelets and Von Willebrand Disease -- Laboratory approach to thrombotic risk -- Antithrombotic therapy -- Overview of the immune system and immunologic disorders -- Immunoassays and immunochemistry -- Laboratory evaluation of the cellular immune system -- Laboratory evaluation of immunoglobin function and humoral immunity -- Mediators of inflammation: complement, cytokines, and adhesion molecules -- Human leukocyte antigen: the major histocompatibility complex of man -- The major histocompatibility complex and disease -- Immunodeficiency disorders -- Clinical and laboratory evaluation of systemic rheumatic diseases -- Vasculitis -- Organ-specific autoimmune diseases -- Allergic diseases -- Viral infections -- Chlamydial, rickettsial, and mycoplasmal infections -- Medical bacteriology -- In vitro testing of antimicrobial agents -- Spirochete infections -- Mycobacteria -- Mycotic diseases -- Medical parasitology -- Molecular pathology of infectious diseases -- Specimen collection and handling for diagnosis of infectious diseases -- Bioterrorism: microbiology -- Introduction to molecular pathology -- Molecular diagnostics: basic principles and techniques -- Polymerase chain reaction and other chain reaction amplification technology -- Hybridization array technologies -- Applications of cytogenetics in modern pathology -- Establishing a molecular diagnostics laboratory -- Molecular diagnosis of hematopoietic neoplasms -- Molecular diagnosis of genetic diseases -- Identity analysis: use of DNA polymorphisms in parentage and forensic testing -- Diagnostic and management of cancer using serologic tumor markers -- Oncoproteins and early tumor detection -- Diagnostic and prognostic impact of high-throughput genomic and proteomic technologies in the post-genomic era.General concepts and administrative issues -- Optimizing laboratory workflow and performance -- Pre-analysis -- Analysis: principles of instrumentation -- Analysis: clinical laboratory automation -- Point-of-care and physician office laboratories -- Post-analysis: medical decision-making -- Interpreting laboratory results -- Laboratory statistics -- Quality control -- Clinical laboratory informatics -- Financial management -- Biological, chemical and nuclear terrorism: role of the laboratory -- Evaluation of renal function, water, electrolytes and acid-base balance -- Biochemical markers of bone metabolism -- Carbohydrates -- Lipids and dyslipoproteinemia -- Evaluation of cardiac injury and function -- Specific proteins -- Clinical enzymology -- Evaluation of liver function -- Laboratory diagnosis of gastrointestinal and pancreatic disorders -- Toxicology and therapeutic drug monitoring -- Evaluation of endocrine function -- Reproductive function and pregnancy -- Vitamins and trace elements -- Basic examination of urine -- Cerebrospinal, synovial, and serous body fluids -- Basic examination of blood and bone marrow -- Hematopoiesis -- Erythrocytic disorders -- Leukocytic disorders -- The flow cytometric evaluation of hematopoietic neoplasia -- Immunohematology -- Transfusion medicine -- Hemapheresis -- Tissue banking and progenitor cells -- Coagulation and fibrinolysis --

Pt. 1. The clinical laboratory. -- General concepts and administrative issues -- Optimizing laboratory workflow and performance -- Pre-analysis -- Analysis: principles of instrumentation -- Analysis: clinical laboratory automation -- Point-of-care and physician office laboratories -- Post-analysis: medical decision-making -- Interpreting laboratory results -- Laboratory statistics -- Quality control -- Clinical laboratory informatics -- Financial management -- Biological, chemical and nuclear terrorism: role of the laboratory -- Pt. 2. Clinical chemistry. -- Evaluation of renal function, water, electrolytes and acid-base balance -- Biochemical markers of bone metabolism -- Carbohydrates -- Lipids and dyslipoproteinemia -- Cardiac injury, atherosclerosis, and thrombotic disease -- Specific proteins -- Clinical enzymology -- Evaluation of liver function -- Laboratory diagnosis of gastrointestinal and pancreatic disorders -- Toxicology and therapeutic drug monitoring -- Evaluation of endocrine function -- Reproductive function and pregnancy -- Vitamins and trace elements -- Chemical basis for analyte assays and common interferences -- Pt. 3. Urine and other body fluids. -- Basic examination of urine -- Cerebrospinal, synovial, and serous body fluids -- Pt. 4. Hematology, coagulation, and transfusion medicine. -- Basic examination of blood and bone marrow -- Hematopoiesis -- Erythrocytic disorders -- Leukocytic disorders -- The flow cytometric evaluation of hematopoietic neoplasia -- Immunohematology -- Transfusion medicine -- Hemapheresis -- Tissue banking and progenitor cells -- Pt. 5. Hemostasis and thrombosis. -- Coagulation and fibrinolysis -- Blood platelets and Von Willebrand Disease -- Laboratory approach to thrombotic risk -- Antithrombotic therapy -- Pt. 6. Immunology and immunopathology. -- Overview of the immune system and immunologic disorders -- Immunoassays and immunochemistry -- Laboratory evaluation of the cellular immune system -- Laboratory evaluation of immunoglobin function and humoral immunity -- Mediators of inflammation: complement, cytokines, and adhesion molecules -- Human leukocyte antigen: the major histocompatibility complex of man -- The major histocompatibility complex and disease -- Immunodeficiency disorders -- Clinical and laboratory evaluation of systemic rheumatic diseases -- Vasculitis -- Organ-specific autoimmune diseases -- Allergic diseases --Pt. 7. Medical microbiology. -- Viral infections -- Chlamydial, rickettsial, and mycoplasmal infections -- Medical bacteriology -- In vitro testing of antimicrobial agents -- Spirochete infections -- Mycobacteria -- Mycotic diseases -- Medical parasitology -- Specimen collection and handling for diagnosis of infectious diseases -- Pt. 8. Molecular pathology. -- Introduction to molecular pathology -- Molecular diagnostics: basic principles and techniques -- Polymerase chain reaction and other chain reaction amplification technology -- Hybridization array technologies -- Applications of cytogenetics in modern pathology -- Establishing a molecular diagnostics laboratory -- Molecular diagnosis of genetic diseases -- Identity analysis: use of DNA polymorphisms in parentage and forensic testing -- Pharmacogenomics and personalized medicine -- Pt. 9. Clinical pathology of cancer -- Diagnostic and management of cancer using serologic tumor markers -- Oncoproteins and early tumor detection -- Molecular diagnosis of hematopoietic neoplasms -- Molecular genetic pathology of solid tumors -- High-throughput genomic and proteomic technologies in the post-genomic era -- Appendix 1. Physiologic solutions, buffers, acid-base indicators, standard reference materials, and temperature conversions -- Appendix 3. Desirable weights, body surface area, and body mass index (BMI) -- Appendix 1. Approximations of total blood volume (TBV) -- Appendix 4. Periodic table of the elements -- Appendix 5. SI units -- Appendix 6. Common chimeric genes identified in human malignancies -- Appendix 7. Disease/organ panels -- Guidelines for ordering blood for elective surgery

MySQL architecture and history -- Benchmarking MySQL -- Profiling server performance -- Optimizing schema and data types -- Indexing for high performance -- Query performance optimization -- Advanced MySQL features -- Optimizing server settings -- Operating system and hardware optimization -- Replication -- Scaling MySQL -- High availability -- MySQL in the cloud -- Application-level optimization -- Backup and recovery -- Tools for MySQL users -- Forks and variants of MySQL -- MySQL server status -- Transferring large files -- Using EXPLAIN -- Debugging locks -- Using Sphinx with MySQL.

General issues -- Critical care medicine -- Medical consultation -- Cardiology -- Vascular medicine -- Pulmonary -- Infectious diseases -- Hiv disease -- Gastroenterology -- Hematology - oncology -- Renal -- Endocrinology -- Rheumatology -- Neurology and psychology -- Toxicology and allergy.

Gross anatomy of the brain -- Neurons and association cells -- Basic neurophysiology -- Blood circulation -- Meninges, ventricles, and cerebrospinal fluid -- Development and growth of the nervous system -- The spinal cord -- Reflexes and muscle tone -- Pain and temperature -- Discriminative general senses, crude touch, and proprioception -- Motorneurons and motor pathways -- Lesions of the spinal nerves and spinal cord -- Brainstem: medulla, pons, and midbrain -- Cranial nerves and chemical senses -- Neurotransmitters as the chemical messengers of certain circuits and pathways -- Auditory and vestibular systems -- Lesions of the brainstem -- Cerebellum -- The visual system -- Autonomic nervous system -- Hypothalamus -- The reticular formation and the limbic system -- Thalamus -- Basal ganglia and extrapyramidal system -- Cerebral cortex.

"It has been 44 years since the publication of the first edition of Hurst's the Heart, the first multidisciplinary and comprehensive textbook on cardiovascular disease. Through 13 editions, The Heart has always represented a cornerstone of current scholarship in the discipline. Cardiologists, internists, and trainees from around the world have relied on its authority, breadth of coverage, and clinical relevance to keep up to date on advances in the field and to help optimize patient care. The 13th edition of The Heart continues and actually exceeds this standard-setting tradition with 19 new chapters and 59 new authors from around the globe who are experts in their respective content areas"--Preface.

v. 1. Diseases, tabular list -- v. 2. Diseases, alphabetic index.

"Revised and updated for its Third Edition, this highly acclaimed volume is a definitive guide to the clinical imaging of foot and ankle disorders. The title of this edition has changed from Radiology of the Foot and Ankle to Imaging of the Foot and Ankle to reflect a greater emphasis on multimodality imaging approaches to solve diagnostic challenges, specifically the increased use of ultrasound, MR imaging, CT, and diagnostic interventional techniques. The book features increased coverage of ultrasound, PET, and the diabetic foot and upgraded MR and CT images. New syndromes such as impingement have been added to the chapter on soft tissue trauma and overuse. The fractures and dislocations chapter includes OTA classifications and additional MR and CT scans of complications. Other highlights include up-to-date information on new fixation devices and prostheses and state-of-the-art interventional and vascular techniques including use of MRA. This book provides a comprehensive reference for radiologists, radiologists in training, and clinicians who treat foot and ankle disorders including podiatrists, orthopaedic surgeons, rheumatologists, and emergency room physicians"--Provided by publisher.

Approach to the patient with seizures / Robert T. Wechsler and Robert S. Fisher -- Electroencephalography in the diagnosis of nonepileptic and epileptic conditions / Warren T. Blume -- Anatomical-clinical localization of ictal behavior / Barbara C. Jobst and Peter D. Williamson -- Curious epileptic seizures that don't resemble seizures / Monisha Goyal, Paul Zarkowski, and Barbara E. Swartz -- Convulsive nonepileptic seizures / Don W. King -- The role of serum prolactin in epileptic seizure diagnosis / Paul B. Pritchard III --Hyperventilation syndrome / Randolph W. Evans -- Psychiatric aspects of nonepileptic seizures: psychogenic NES / John R. Gates -- Coexisting epilepsy and nonepileptic seizures / Allan Krumholz and Tricia Ting -- Panic attacks and panic disorders: the great imitators / Meghan M. Grady and Stephen Stahl.Nonepileptic spells in neonates and infants / Linda Laux and Douglas R. Nordli -- Nonepileptic seizures and similar phenomena in children and adolescents / J.B.P. Stephenson and Sameer Zuberi --Paroxysmal disturbances resembling epileptic seizures in the elderly / A. James Rowan -- -- Migraine and epilepsy / Audrey Halpern and Stephen D. Silberstein -- Strange tastes, smells, sounds, visions and feelings: nonepileptic events that mimic simple partial seizures / Ross Finesmith, Eric B. Geller, and Orrin Devinsky -- Dizziness or vestibular problems resembling seizures / Martin Gizzi and Sidney P. Diamond -- Movement disorders that imitate epilepsy / Ann Helms and Lisa Shulman -- Hyperekplexia and other disorders of startle: differential diagnosis with epilepsy / Frederick Andermann and Eva Andermann -- Encephalopathy as a mimic of seizures / Michael Benatar and Frank Drislane -- Neuroendocrine, metabolic, and toxic imitators of epilepsy / Robin Gilmore -- Parasomnias, sleep disorders, and narcolepsy--sleep-time imitators of epilepsy / Carl W. Bazil -- Cerebrovascular imitators of epilepsy / Louis R. Caplan --

pt. 1. Methods in infectious disease epidemiology. -- Early history of infectious disease: epidemiology and control of infectious diseases -- Epidemiology of infectious disease: general principles -- Study design -- Surveillance -- Outbreak epidemiology -- Mathematical modeling: the dynamics of infection -- Microbiology tools for the epidemiologist -- Molecular epidemiology and infectious diseases -- Geographic information systems -- Vaccines- past, present and future -- Nutrition and infectious diseases. -- pt. 2. Emerging and nosocomial infections. -- Emerging and new infectious diseases --Nosocomial infections. -- pt. 3. Airborne transmission. -- Tuberculosis -- Epidemiology of acute respiratory infections -- Epidemiology and prevention of influenza. -- pt. 4. Diarrheal diseases. -- Diarreheal diseases. -- pt. 5. Blood and body fluid as a reservoir of infectious diseases. -- Review of the epidemiology of human immunodeficiency virus infection and acquired immune deficiency syndrome -- Viral hepatitis -- Sexually transmitted diseases. -- pt. 6. Vectorborne and parasite diseases. -- Lyme disease -- Epidemiology and control of malaria -- Epidemiology of helminth infections.

Alcohol: social damages, abuse, and dependence -- Alcohol: health effects -- Cannabis: effects of consumption on health -- Childhood obesity: screening and prevention -- Psychotherapy: three approaches evaluated -- Dioxins in the Environment: what are the health risks? -- Health education for young people: approaches and methods -- Mental disorders: children and adolescents screening and prevention.

v. 1. Diseases, tabular list -- v. 2. Diseases, alphabetic index.

Introduction to normal values (reference ranges) -- Critical values -- Core blood analytes: alterations by diseases -- Urine -- Cardiovascular diseases -- Respiratory diseases -- Gastrointestinal diseases -- Hepatobiliary diseases and diseases of the pancreas -- Central and peripheral nervous system disorders -- Musculoskeletal and joint diseases -- Hematology -- Metabolic and hereditary disorders -- Endocrine diseases -- Genitourinary diseases -- Infectious diseases -- Autoimmune and miscellaneous diseases -- Disorders due to physical and chemical agents -- Therapeutic drug monitoring and drug effects -- Body substances.

Diagnosis and classification -- Interviewing and assessment -- The neurobiology and genetics of mental illness -- Delirium, dementia, and amnestic disorder -- Schizophrenia and other psychotic disorders -- Mood disorders -- Anxiety disorders -- Somatoform, dissociative, and related disorders -- Alcohol- and drug-related disorders -- Personality disorders -- Sexual dysfunction, paraphilias, and gender identity disorders -- Eating disorders -- Adjustment disorders -- Impulse-control disorders -- Psychiatric emergencies -- Child psychiatry -- Sleep disorders -- Legal issues -- Behavioral, cognitive, and psychodynamic treatments -- Psychopharmacology and electroconvulsive therapy.