Lane Medical Library

Early steps of V(D)J rearrangement : insights from biochemical studies of RAG-RSS complexes / Patrick C. Swanson, Sushil Kumar, and Prafulla Raval -- Regulation of RAG transposition / Adam G.W. Matthews and Marjorie A. Oettinger -- Recent insights into the formation of RAG-induced chromosomal translocations / Vicky L. Brandt and David B. Roth -- V(D)J recombination deficiencies / Jean-Pierre de Villartay -- Large-scale chromatin remodeling at the immunoglobulin heavy chain locus : a paradigm for multigene regulation / Daniel J. Bolland, Andrew L. Wood, and Anne E. Corcoran -- Genetic and epigenetic control of V gene rearrangement frequency / Ann J. Feeney -- Dynamic aspects of TCRa gene recombination : qualitative and quantitative assessments of the TCRa chain repertoire in man and mouse / Evelyne Jouvin-Marche, Patrizia Fuschiotti, and Patrice Noël Marche -- Germline transcription : a key regulator of accessibility and recombination / Iratxe Abarrategui and Michael S. Krangel --Dynamic regulation of antigen receptor gene assembly / Lance R. Thomas, Robin Milley Cobb, and Eugene M. Oltz -- Molecular genetics at the T-cell receptor b locus : insights into the regulation of V(D)J recombination / Marie Bonnet, Pierre Ferrier, and Salvatore Spicuglia -- Molecular pathways and mechanisms regulating the recombination of immunoglobulin genes during B-lymphocyte development / Kristen Johnson, Karen L. Reddy, and Harinder Singh -- Regulation of V(D)J recombinationby E-protein transcription factors / Mary Elizabeth Jones and Yuan Zhuang -- Temporal and spatial regulation of V(D)J recombination : interactions of extrinsic factors with the RAG complex / Yun Liu, Li Zhang, and Stephen Desiderio -- V(D)J recombination : of mice and sharks / Ellen Hsu -- Normal and pathological V(D)J recombination : contribution to the understanding of human lymphoid malignancies / Saïda Dadi ... [et al.].

A biography of the late immunologist follows his tireless quest to eradicate disease, discussing the history of the field of immunology, current controversy about the link between vaccines and autism, and Hilleman's success in developing the first mumps vaccine.

Microbial pathogenesis and the discovery of toll-like receptor function / Bruce Beutler -- Dendritic cells: targets for immune modulation by microbes and immunologists / Bali Pulendran ... [et al.] -- Achieving transcriptional specificity in NF-[gamma]B-dependent inflammatory gene expression / Gioacchino Natoli -- Adjuvants and the initiation of t-cell responses / Matthew F. Mescher, Julie M. Curtsinger, and Marc Jenkins -- Mechanism for recognition of CpG DNA / Kiyoshi Takeda, Hiroaki Hemmi, and Shizuo Akira -- CpG ODN as a Th1 immune enhancer for prophylactic and therapeutic vaccines / Arthur M. Kried and Heather L. Davis -- Modified bacterial toxins / Ed C. Lavelle, Olive Leavy, and Kingston H.G. Mills -- Glycosylphosphatidylinositol anchors as natural immunological adjuvants derived from protozoan parasites / Ricardo T. Gazzinelli ... [et al.] -- The immunomodulatory glycan LNFPIII/Lewis X functions as a potent adjuvant for protein antigens / Mitsuhiro Okano ... [et al.] -- Immune and antiviral effects of the synthetic immunomodulator murabutide: molecular basis and clinical potential / George M. Bahr -- Effect of QS-21 on innate and adaptive immune responses / Charlotte Read Kensil ... [et al.] -- Monophosphoryl lipid A and synthetic lipid a mimetics as TLR4-based adjuvants and immunomodulators / Jory Baldridge ... [et al.] -- Microparticles and DNA vaccines / Kimberly Denis-Mize ... [et al.].

Development of vaccine adjuvants : a historical perspective / Gary Ott and Gary Van Nest -- Antigen processing and presentation / Subash Sad -- Mechanisms of adjuvant action / Nils Lycke -- Aluminum-containing adjuvants : properties, formulation, and use / Stanley L. Hem and Harm HogenEsch -- MF59 : a safe and potent oil-in-water emulsion adjuvant / Derek T. O'Hagan and Manmohan Singh -- TLR4 agonists as vaccine adjuvants / David A. Johnson and Jory R. Baldridge -- Immunostimulatory CpG oligodeoxynucleotides as vaccine adjuvants / Dennis M. Klinman, Debbie Currie, and Hidekazu Shirota -- Small molecule immunopotentiators as vaccine adjuvants / Fengfeng Xu, Nicholas M. Valiante, and Jeffrey B. Ulmer -- New ISCOMs meet unsettled vaccine demands / Bror Morein ... [et al.] -- Surface-charged poly(lactide-co-glycolide) microparticles as novel antigen delivery systems / Manmohan Singh ... [et al.] -- Liposomal cytokines and liposomes targeted to co-stimulatory molecules as adjuvants for HIV subunit vaccines / Bulent Ozpolat and Lawrence B. Lachman -- Archaeosome vaccine adjuvants for cross-priming CD8+ T-cell immunity / Lakshmi Krishnan and G. Dennis Sprott -- Mucosal adjuvants and delivery systems / Michael Vajdy -- Cytokines as vaccine adjuvants / Nejat K. Egilmez -- Polyphosphazenes as vaccine adjuvants / Alexander K. Andrianov -- Vaccine delivery by transdermal electroporation / Amit Misra -- Nonclinical safety assessment of vaccines and the evaluation of novel adjuvants and delivery systems / Jose A. Lebron ... [et al.] -- Safety evaluation of vaccine adjuvants / Erik B. Lindblad.

In this account of vaccination's miraculous, inflammatory past and its uncertain future, journalist Arthur Allen reveals a history both illuminated with hope and shrouded by controversy--from Edward Jenner's discovery of smallpox vaccine in 1796 to Pasteur's vaccines for rabies and cholera, to those that safeguarded the children of the twentieth century, and finally to the tumult currently surrounding vaccination. Faced with threats from anthrax to AIDS, we are a vulnerable population and can no longer depend on vaccines; numerous studies have linked childhood vaccination with various neurological disorders, and our pharmaceutical companies are more attracted to the profits of treatment than to the prevention of disease.--From publisher description.

Immunological approaches for tolerance induction in allergy -- Clinical experience with recombinant molecules for allergy vaccination -- Allergen-specific immunotherapy with recombinant allergens -- Vaccine approaches for food allergy -- Intralymphatic immunotherapy: From the rationale to human applications -- Induction of allergen-specific tolerance via mucosal routes -- T cell epitope-based allergy vaccines -- Allergen-specific immunotherapy: Towards combination vaccines for allergic and infectious diseases -- Passive immunization with allergen-specific antibodies -- Cell-based therapy in allergy -- Current strategies for allergen-specific immunotherapy at its centenary.

Part I. Pandemic Influenza Overview -- Pandemic influenza as a current threat -- Antigenic cross-reactivity among H5N1 Viruses -- -- Part II. Current Approaches for Human and Avian Vaccine Production -- Seasonal influenza vaccines -- Generation and characterization of candidate vaccine viruses for pre-pandemic influenza vaccines -- Live attenuated vaccines for pandemic influenza -- Influenza vaccines for avian species -- Development and application of avian influenza vaccines in China -- -- Part III. Novel Vaccine Approaches -- Designing vaccines for pandemic influenza -- Attenuated influenza virus vaccines with modified NS1 proteins -- DNA Vaccines against Influenza viruses -- Recombinant proteins produced in insect cells -- Influenza neuraminidase as a vaccine antigen -- Recombinant vectors as influenza vaccines -- Influenza virus-like particles as pandemic vaccines -- Pandemic influenza vaccines -- Adjuvants for pandemic influenza vaccines -- -- Part IV. Novel Approaches of Vaccine Delivery -- Transcutaneous immunization with influenza vaccines -- Microneedle-based vaccines -- -- Part V. Vaccine Evaluation, Production and Distribution -- Animal models for evaluation of influenza vaccines -- Immunosenescence and influenza vaccine efficacy -- Vaccines for pandemic influenza: summary of recent clinical trials -- Considerations for licensure of influenza vaccines with pandemic and pre-pandemic indications -- Strategies for broad global access to pandemic influenza -- Prioritization of pandemic influenza vaccine: rationale and strategy for decision-making.

A short history of vaccination / Susan L. Plotkin, Stanley A. Plotkin -- Vaccine immunology / Claire-Anne Siegrist -- The vaccine industry / R. Gordon Douglas, Jerald C. Sadoff, Vijay B. Samant -- Vaccine manufacturing / Phillip L. Gomez, James M. Robinson, Joseph A. Rogalewicz -- Immunologic adjuvants / Frederick R. Vogel, Stanley L. Hem -- Vaccine additives and manufacturing residuals in United States-licenced vaccines / Theresa M. Finn, William Egan -- General immunization practices / William L. Atkinson, Andrew L. Kroger, Larry K. Pickering -- Anthrax vaccines / Philip S. Brachman, Arthur M. Friedlander, John D. Grabenstein -- Cholera vaccines / Carol O. Tacket, David A. Sack -- Diphtheria toxoid / Charles R. Vitek, Melinda Wharton -- Haemophilus influenzae vaccines / Aruna Chandran, James P. Watt, Mathuram Santosham -- Hepatitis A vaccines / Anthony E. Fiore, Stephen M. Feinstone, Beth P. Bell -- Hepatitis B vaccines / Eric E. Mast, John W. Ward -- Human papillomavirus vaccines / John T. Schiller, Ian H. Frazer, Douglas R. Lowy -- Inactivated influenza vaccines / Carolyn B. Bridges ... [et al.] -- Influenza vaccine--live / Robert B. Belshe ... [et al.] -- Japanese encephalitis virus vaccines / Scott B. Halstead, Julie Jacobson -- Measles vaccines / Peter M. Strebel ... [et al.] -- Meningococcal vaccines / Dan M. Granoff, Lee H. Harrison, Ray Borrow -- Mumps vaccines / Stanley A. Plotkin, Steven A. Rubin -- Pertussis vaccines / Kathryn M. Edwards, Michael D. Decker -- Plague vaccines / E. Diane Williamson, Andrew J. Simpson, Richard W. Titball -- Pneumococcal conjugate vaccine and pneumococcal common protein vaccines / Steven Black ... [et al.] -- Pneumococcal polysaccharide vaccines / Lisa A. Jackson, Kathleen M. Neuzil -- Poliovirus vaccine-inactivated / Stanley A. Plotkin, Emmanuel Vidor -- Poliovirus vaccine-live / Roland W. Sutter, Olen M. Kew, Stephen L. Cochi -- Rabies vaccines / Stanley A. Plotkin, Hilary Koprowski, Charles E. Rupprecht -- Rotavirus vaccines / H. Fred Clark ... [et al.] -- Rubella vaccine / Stanley A. Plotkin, Susan E. Reef -- Smallpox and vaccinia / Donald A. Henderson, Luciana L. Borio, John D. Grabenstein -- Tetanus toxoid / Steven G.F. Wassilak ... [et al.] -- Tick-borne encephalitis virus vaccines / P. Noel Barrett, Stanley A. Plotkin, Hartmut J. Ehrlich -- Tuberculosis vaccines / Kim Connelly Smith, Ian M. Orme, Jeffrey R. Starke -- Typhoid fever vaccines / Myron M. Levine -- Varicella vaccine / Anne A. Gershon, Michiaki Takahashi, Jane F. Seward -- Yellow fever vaccine / Thomas P. Monath, Martin S. Cetron, Dirk E. Teuwen -- Zoster vaccine / Myron J. Levin -- Combination vaccines / Michael D. Decker, Kathryn M. Edwards, Hugues H. Bogaerts -- Adenovirus vaccines / Charlotte A. Gaydos, Gregory C. Gray -- Biodefense and special pathogen vaccines / Philip Pittman, Stanley A. Plotkin -- Therapeutic cancer vaccines / Neil L. Berinstein, David Spaner -- Cytomegalovirus vaccines / Stanley A. Plotkin -- Dengue vaccines / Scott B. Halstead, David W. Vaughn -- Diarrheal disease vaccines / James P. Nataro, Eileen M. Barry -- Ebola vaccines / Nancy J. Sullivan, Gary J. Nabel -- Epstein-Barr virus vaccines / Joanne E. Davis, Denis J. Moss -- Hepatitis C virus vaccines / Eva Reali, Michael Houghton, Sergio Abrignani -- Hepatitis E virus vaccines / Robert H. Purcell, Suzanne U. Emerson -- Herpes simplex virus vaccines / Lawrence R. Stanberry -- Human immunodeficiency virus vaccines / Marc P. Girard, Wayne C. Koff -- Lyme disease vaccines / Allen C. Steere -- Malaria vaccines / Filip Dubovsky, Elissa Malkin -- Noninfectious disease vaccines / George R. Siber -- Respiratory syncytial virus and parainfluenza virus vaccines / Ruth A. Karron -- Parasitic disease vaccines / Peter J. Hotez, Jeffrey M. Bethony -- Severe acute respiratory syndrome (SARS) vaccines / Bart L. Haagmans, Albert D.M.E. Osterhaus -- Staphylococcus aureus vaccines / Robert S. Daum -- Streptococcus group A vaccines / Karen L. Kotloff -- Streptococcus group B vaccines / C. Mary Healy, Carol J. Baker -- Technologies for making new vaccines / Ronald W. Ellis -- Alternative vaccine delivery methods / Bruce G. Weniger, Mark J. Papania -- The development of gene-based vectors for immunization / Gary J. Nabel --- Vaccination in the immunocompromised host / Per Ljungman -- Vaccination of human immunodeficiency virus-infected persons / William J. Moss, Neal A. Halsey -- Vaccines for international travel / Elizabeth D. Barnett, Phyllis E. Kozarsky, Robert Steffen -- Vaccines for health care workers / David J. Weber, William A. Rutala -- Immunization in the United States / Walter A. Orenstein ... [et al.] -- Immunization in Europe / David M. Salisbury, John S. Spika -- Immunization in the Asia-Pacific region / Theodore F. Tsai, Zhi Yi Xu -- Immunization in developing countries / Stephen C. Hadler ... [et al.] -- Community immunity / Paul E.M. Fine, Kim Mulholland -- Economic analyses of vaccine policies / Mark A. Miller, Alan R. Hinman -- Regulation and testing of vaccines / Norman W. Baylor, Karen Midthun -- Vaccine safety / Paul A. Offit, Robert L. Davis, Deborah Gust -- Legal issues / Geoffrey Evans, Emily Marcus Levine, Elizabeth H. Saindon -- Ethics / Arthur L. Caplan, Jason L. Schwartz.

An in vitro transcription system for studying Vaccinia virus early genes / Steven S. Broyles and Marcia Kremer -- An in vitro transcription system for studying Vaccinia virus late genes / Cynthia F. Wright -- Studying Vaccinia virus RNA processing in vitro / Paul D. Gershon -- Methods for analysis of poxvirus DNA replication / Paula Traktman and Kathleen Boyle -- Studying the binding and entry of the intracellular and extracellular enveloped forms of Vaccinia virus / Mansun Law and Geoffrey L. Smith -- Pox, dyes, and videotape: making movies of GFP-labeled Vaccinia virus / Brian M. Ward -- Interaction analysis of viral cytokine-binding proteins: using surface plasmon resonance / Bruce T. Seet and Grant McFadden -- Monitoring of human immunological responses to Vaccinia virus / Richard Harrop ... [et al.] -- Vaccinia virus as a tool for immunologic studies / Nia Tatsis, Gomathinayagam Sinnathamby, and Laurence C. Eisenlohr -- Mouse models for studying orthopoxvirus respiratory infections / Jill Schriewer, R. Mark L. Buller, and Gelita Owens --Viral glycoprotein-mediated cell fusion assays using Vaccinia virus vectors / Katharine N. Bossart and Christopher C. Broder -- Use of dual recombinant Vaccinia virus vectors to assay viral glycoprotein-mediated fusion with transfection-resistant primary cell targets / Yanjie Yi ... [et al.] -- Poxvirus bioinformatics / Chris Upton -- Preparation and use of molluscum contagiosum virus from human tissue biopsy specimens / Nadja V. Melquiot and Joachim J. Bugert.Working safely with Vaccinia virus: laboratory technique and the role of Vaccinia vaccination / Stuart N. Isaacs -- Construction and isolation of recombinant Vaccinia virus using genetic markers / María M. Lorenzo, Inmaculada Galindo, and Rafael Blasco -- Construction of recombinant Vaccinia virus: cloning into the thymidine kinase locus / Chelsea M. Byrd and Dennis E. Hruby -- Transient and inducible expression of Vaccinia/T7 recombinant viruses / Mohamed Ragaa Mohamed and Edward G. Niles -- Construction of recombinant Vaccinia viruses using leporipoxvirus-catalyzed recombination and reactivation of orthopoxvirus DNA / Xiao-Dan Yao and David H. Evans -- Construction of cDNA libraries in Vaccinia virus / Ernest S. Smith, Shuying Shi, and Maurice Zauderer -- Construction and isolation of recombinant MVA / Caroline Staib, Ingo Drexler, and Gerd Sutter -- Growing poxviruses and determining virus titer / Girish J. Kotwal and Melissa-Rose Abrahams -- Rapid preparation of Vaccinia virus DNA template for analysis and cloning by PCR / Rachel L. Roper -- Orthopoxvirus diagnostics / Hermann Meyer, Inger K. Damon, and Joseph J. Esposito --

"This publication addresses the broader issues of social cost-benefit analysis performed on options to invest in drinking-water supplies, with a focus on small community suppliers"--Back cover.

The Mitral Valve Disease / Michael Henein and John Pepper -- Aortic Valve Disease / Michael Henein and Joseph Maalouf -- Right Heart Valve Disease / Michael Henein -- Pulmonary Valve Disease / Michael Henein and Wei Li -- Stress Echo in Valvular Heart Disease / Eugenio Picano -- Valve Substitutes / John Chambers -- Native and Prosthetic Valve Endocarditis / Maurizio Galderisim and Sergio Mondillo.

Variation and variability : central concepts in biology / Benedikt Hallgrímsson and Brian K. Hall -- Variation from Darwin to the modern synthesis / Peter J. Bowler -- The statistics of variation / Leigh Van Valen -- Landmark morphometrics and the analysis of variation / Joan T. Richtsmeier, Subhash R. Lele, and Theodore M. Cole III -- Variation in ontogeny / Donna Carlson Jones and Rebecca Z. German -- Constraints on variation from genotype through phenotype to fitness / Lauren Ancel Meyers -- Developmental origins of variation / Ellen Larsen -- Canalization, cryptic variation, and developmental buffering : a critical examination and analytical perspective / Ian Dworkin -- Mutation and phenotypic variation : where is the connection? : capacitators, stressors, phenotypic variability, and evolutionary change / Ary A. Hoffmann and John A. McKenzie -- Within individual variation : developmental noise versus developmental stability / Katherine E. Willmore and Benedikt Hallgrímsson -- Developmental constraints, modules, and evolvability / Christian Peter Klingenberg -- Developmental regulation of variability / Miriam Leah Zelditch -- Role of stress in evolution : from individual adaptability to evolutionary adaptation / Alexander V. Badyaev -- Environmentally contingent variation : phenotypic plasticity and norms of reaction / Sonia E. Sultan and Stephen C. Stearns -- Variation and life-history evolution / Derek A. Roff -- Antisymmetry / A. Richard Palmer -- Variation in structure and its relationship to function : correlation, explanation, and extrapolation / Anthony P. Russell and Aaron M. Bauer -- A universal generative tendency toward increased organismal complexity / Daniel W. McShea -- Variation and versatility in macroevolution / V. Louise Roth -- Variation and developmental biology : prospects for the future / David M. Parichy -- Phenogenetics : genotypes, phenotypes, and variation / Samuel Sholtis and Kenneth M. Weiss -- The study of phenotypic variability : an emerging research agenda for understanding the developmental-genetic architecture underlying phenotypic variation / Benedikt Halgrímsson, Jevon James Yardley Brown, and Brian K. Hall.

The Varicella-zoster virus genome -- VZV molecular epidemiology -- Roles of cellular transcription factors in VZV replication -- Effects of Varicella-zoster virus on cell cycle regulatory pathways -- Varicella-zoster virus open reading frame 66 protein kinase and its relationship to alphaherpesvirus US3 kinases -- VZV ORF 47 serine protein kinase and its viral substrates -- Overview of Varicella-zoster virus glycoproteins gC, gH and gL -- Analysis of the function of glycoproteins E and I and their promoters during VZV replication in virto and in skin and T cell xenografts in the SCID mouse model of VZV pathogenesis -- Varicella-zoster virus glycoprotein M -- Varicella zoster virus immune evasion strategies -- VZV Infection of keratinocytes: production of cell-free infectious virions in vivo -- Varicella-zoster virus T cell tropism and the pathogenesis of skin infection -- Experimental models to study varicella zoster virus infection of neurons -- Molecular characterization of Varicella zoster virus (VZV) in latently infected human ganglia: physical state and abundance of VZV DNA, quantitation of viral transcripts and detection of VZV-specific proteins -- Neurological disease produced by Varicella zoster virus reactivation without rash -- Varicella-zoster virus neurotropism in SCID mouse-human DRG xenografts -- Rodent models of Varicella-zoster virus neurotropism -- Simian Varicella virus: molecular virology -- Simian Varicella virus pathogenesis -- Varicella-zoster virus vaccine : molecular genetics -- VZV T-cell-mediated immunity -- Perspectives on vaccines against Varicella-zoster virus infections.

Development of vascular access surgery -- Patient assessment and planning for vascular access surgery -- Anesthesia for vascular access surgery -- Surgical anatomy for hemodialysis access -- Physiology of the arteriovenous fistula -- Thrombophilia as a cause of recurrent vascular access thrombosis in hemodialysis patients -- Biologic properties of venous access devices -- Biologic response to prosthetic dialysis grafts -- Strategies to reduce intimal hyperplasia in dialysis access grafts -- Epidemiology and pathophysiology of chronic renal failure and guidelines for initiation of hemodialysis -- Autologous arteriovenous fistulas: direct radiocephalic anastomosis for hemodialysis access -- Autogenous vein for fistulas and interposition grafts -- Basili vein transposition: a modern autogenous vascular access for hemodialysis -- Interposition arteriovenous grafts (bridge fistulas) for hemodialysis -- New synthetic grafts and early access -- Central venous cannulation for hemodialysis access -- Access in the neonatal and pediatric patient -- Surveillance, revision, and outcome of vascular access procedures for hemodialysis -- Endovascular management of dialysis graft stenosis -- Axillosubclavian vein thrombosis -- Complications of vascular access: thrombosis, venous hypertension, congestive heart failure, neuropathy, and aneurysm -- Dialysis access-associated ischemic steal syndrome -- Vascular access neuropathic syndrome: ischemic monomelic neuropathy -- Infection in vascular access procedures -- Assessment and intervention for arteriovenous fistula maturation -- Coordination and patient care in vascular access -- Cardiovascular consequences of rapid hemodialysis -- Peritoneal dialysis -- Socioeconomic implications of vascular access surgery -- Ultrasound in vascular access -- Reflections on four decades of experience in vascular access surgery -- Organizing hemodialysis access: the kaiser permanente southern California experience -- Should the KDOQI guidelines for first time dialysis access apply to all patients? -- Ten mistakes to avoid in dialysis access surgery -- Placement of indwelling venous access systems -- Vascular access for trauma, emergency surgery, and critical care -- Complications of percutaneous vascular access procedures and their management.

Patient evaluation and care -- Standard angiographic and interventional techniques -- Pathogenesis of vascular diseases -- Thoracic aorta -- Abdominal aorta -- Pelvic and lower extremity arteries -- Upper extremity arteries -- Renal arteries and veins -- Mesenteric arteries -- Hepatic, splenic, and portal vascular systems -- Endocrine, exocrine, and reproductive systems -- Pulmonary and bronchial arteries -- Lower extremity veins -- Inferior vena cava -- Upper extremity veins and superior vena cava -- Vascular access placement and foreign body retrieval -- Hemodialysis access -- Lymphatic system -- Percutaneous biopsy -- Transcatheter fluid drainage -- Gastrointestinal interventions -- Biliary system -- Urologic and genital systems.

Rat carotid artery balloon injury model / David A. Tulis -- Histological and morphometric analyses for rat carotid balloon injury model / David A. Tulis -- Plaque rupture model in mice / Takeshi Sasaki, Kae Nakamura and Masafumi Kuzuya -- Immunostaining of mouse atherosclerotic lesions / Hong Lu, Debra L. Rateri and Alan Daugherty -- Surgical animal model of ventricular hypertrophy / Giuseppe Marano and Alberto U. Ferrari -- Animal models of hypertension / Brett M. Mitchell, Thomas Wallerath and Ulrich Förstermann -- Rat models of cardiac insulin resistance / Sanjoy Ghosh, Brian Rodrigues and Jun Ren -- The Isolated, perfused pseudo-working heart model / Gary J. Grover and Rajni Singh -- Altering and analyzing glucose metabolism in perfused hearts of transgenic mice / Rajakumar V. Donthi and Paul N. Epstein -- Methods in the evaluation of cardiovascular renin angiotensin aldosterone activation and oxidative stress / Camila Manrique -- Detection and quantification of apoptosis in the vasculature / Wendy A. Boivin and David J. Granville -- Endothelial progenitor cell and mesenchymal stem cell isolation, characterization, viral transduction / Keith R. Brunt, Sean R. R. Hall, Christopher A. Ward, and Luis G. Melo -- Assessment of endothelial damage/dysfunction: a focus on circulating endothelial cells / Christopher J. boos, Andrew D. Blann, and Gregory Y. H. Lip -- Evaluation of endothelial function by in vivo microscopy / Rosario Scalia -- Hapotaxis of endothelial cell migration under flow / Steve Hsu, Rahul Thakar, and Song Li -- Isolation, culture, and functional analysis of adult mouse cardiomyocytes / Ronglih Liao and Mohit Jain -- Mechanical measurement of contractile function of isolated ventricular myocytes / Loren E. Wold and Jun Ren -- Studying ischemia and reperfusion in isolated neonatal rat ventricular myocytes using coverslip hypoxia / Kelly R. Pitts and Christopher F. Toombs -- Isolation and functional studies of rat aortic smooth muscle cells / Nair Sreejayan and Xiaoping Yang -- Detection of reactive oxygen species and nitric oxide in vascular cells and tissues / Hua Cai, Sergey Dikalow, Kathy K. Griendling, and David G. Harrison -- Assessment of protein glycoxidation in ventricular tissues / Shi-Yan Li and Jun Ren -- Assessment of PI-3 kinase and Akt in ischemic heart diseases in diabetes / Takashi Matsui and Amy J. Davidoff -- Two-dimensional gel electrophoresis in platelet proteomics research / Ángel García -- Stem cell therapy in the heart and vasculature / Loren E. Wold, Wangde Dai, Joan S. Dow, and Robert A. Kloner.

CT basics -- Concepts in radiation -- Technical aspects of vascular CT angiography -- Carotid and upper extremity CT angiography -- Thoracic aortic CT angiography -- Abdominal aortic CT angiography -- Peripheral arterial CT angiography.

The aging population and the importance of vascular dementia / Kelly L. Lange and Robert H. Paul -- Clinical forms of vascular dementia / Gustavo C. Román -- Neuropathological substrates of vascular ischemic dementia / Kurt A. Jellinger -- Diagnosis of vascular dementia : conceptual challenges / José G. Merino and Vladimir Hachinski -- Cerebral hemodynamics in the elderly / Jorge M. Serrador and Lewis A. Lipsitz -- The cadasil syndrome and other genetic causes of stroke and vascular dementia / Stephen Salloway and Sophie Desbiens -- Estrogen, the cerebrovascular system, and dementia / Sharon X.C. Yang and George A. Kuchel -- Hypertension and cerebrovascular disease : effects of hypertension on young and middle-aged rhesus monkeys / Mark B. Moss and Elizabeth M. Jonak -- The cognitive profile of vascular dementia / Angela Lee Jefferson ... [et al.] -- Progression of cognitive impairments associated with cerebrovascular disease / Sally Stephens ... [et al.] -- Neuropsychiatric correlates of vascular injury : vascular dementia and related neurobehavioral syndromes / Anand Kumar, Helen Lavretsky, and Ebrahim Haroon -- Functional impairment in vascular dementia / Patricia A. Boyle and Deborah Cahn-Weiner -- Functional brain imaging of cerebrovascular disease / Ronald Cohen ... [et al.] -- Contributions of subcortical lacunar infarcts to cognitive impairment in older persons / Dan Mungas --White matter hyperintensities and cognition / David J. Moser, Jason E. Kanz, and Kelly Davis Garrett -- Poststroke dementia : the role of strategic infarcts / Anelyssa D'Abreu and Brian R. Ott -- Understanding incidence and prevalence rates in mixed dementia / John Gunstad and Jeffery Browndyke -- Vascular basement membrane abnormalities and alzheimer's disease / Edward G. Stopa, Brian D. Zipser, and John E. Donahue -- Amyloid beta and the cerebral vasculature / Paula Grammas -- Cerebrovascular disease and the expression of Alzheimer's disease / Margaret M. Esiri and Zsuzsanna Nagy -- The neuropsychological differentiation between Alzheimer's disease and subcortical vascular dementia / David J. Libon ... [et al.] -- Pharmacological treatment of vascular dementia / Timo Erkinjuntti ... [et al.] -- Understanding and managing caregiver burden in cerebrovascular disease / Geoffrey Tremont, Jennifer Duncan Davis, and Mary Beth Spitznagel -- Quality of life in patients with vascular dementia / Rebecca E. Ready and Brian R. Ott -- Approaches to neuroprotection and recovery enhancement after acute stroke / Marc Fisher and Magdy Selim.

Part 1. Pre-clinical development -- The Discovery and Characterisation of Tumour Endothelial Markers / Dario Neri and Roy Bicknell -- The Use of Animal Models in the Assessment of Tumour Vascular Disrupting Agents (VDAs) / R. Barbara Pedley and Gillian M. Tozer -- Combination Therapy with Chemotherapy and VDAs / Giulia Taraboletti, Katiuscia Bonezzi and Raffaella Giavazzi -- Lessons from Animal Imaging in Preclinical Models / Lesley D. McPhail and Simon P. Robinson -- Combining Antiangiogenic Drugs with Vascular Disrupting Agents Rationale and Mechanisms of Action / Yuval Shaked, Paul Nathan, Laura G. M. Daenen and Robert S. Kerbel -- Development of Vascular Disrupting Agents / Graeme J. Dougherty and David J. Chaplin -- Part 2. Imaging in the development of vascular disruptive agents -- MRI to Assess Vascular Disruptive Agents / Martin Zweifel and Anwar R. Padhani -- Contrast Ultrasound in Imaging Tumor Angiogenesis / Grzegorz Korpanty and Rolf A. Brekken -- Part 3. Clinical development -- The Clinical Development of Tubulin Binding Vascular Disrupting Agents / Martin Zweifel and Gordon Rustin -- ASA404 (DMXAA): New Concepts in Tumour Vascular Targeting Therapy / Bruce C. Baguley -- Vascular Disruptive Agents in Combination with Radiotherapy / Henry C. Mandeville and Peter J. Hoskin.

Tumor vasculature : a target for anticancer therapies / Dietmar W. Siemann -- Abnormal microvasculature and defective microcirculatory function in solid tumors / Peter Vaupel -- The role of microvasculature in metastasis formation / Oliver Stöltzing, Lee M. Ellis -- Development of agents that selectively disrupt tumor vasculature : a historical perspective / David J. Chaplin, Sally A. Hill -- Morphologic manifestations of vascular-disrupting agents in preclinical models / Mumtaz V. Rojiani, Amyn Rojiani -- Molecular recognition of the colchicine binding site as a design paradigm for the discovery and development of vascular disrupting agents / Kevin G. Pinney -- Combined modality approaches using vascular-disrupting agents / Wenyin Shi, Michael R. Horsman, Dietmar W. Siemann -- Vascular-targeting therapies and hyperthermia / Michael R. Horsman, Rumi Murata -- Flavones and xanthenones as vascular-disrupting agents / Bronwyn G. Siim, Bruce C. Baguley -- Targeting inside-out phospholipids on tumor blood vessels in pancreatic cancer / Adam W. Beck, Rolf Brekken, Philip E. Thorpe -- Cadherin antagonists as vascular-targeting agents / Orest Blaschuk, Tracey M. Rowlands -- Alphastatin : a pluripotent inhibitor of activated endothelial cells / Carolyn A. Staton, Claire Lewis -- Cationic lipid complexes to target tumor endothelium / Uwe Michaelis, Michael Teifel -- Development of vascular-targeting cancer gene therapy / Graeme J. Dougherty, Peter D. Davis, Shona T. Dougherty -- Vascular-disrupting strategies combined with bacterial spores targeting hypoxic regions of solid tumors / G-One Ahn, J. Martin Brown -- Imaging the effects of vascular-targeting agents / Susan M. Galbraith -- Clinical progress in tumor vasculature-disrupting therapies / Andrew M. Gaya, Gordon J. S. Rustin -- Use of vascular-disrupting agents in non-oncology indications / Joseph C. Randall, Scott Young.

Definitions -- Classification and epidemiology -- General presentation of the vasculitides -- General principles of treatment -- Giant cell arteritis -- Takayasu arteritis -- Wegener's granulomatosis -- Churg-Strauss syndrome -- Microscopic polyangiitis -- Polyarteritis nodosa -- Kawasaki disease -- Henoch-Schonlein purpura -- Behcet's dsease -- Cryoglobulinemic vasculitis -- Vasculitis mimics -- Secondary vasculitis -- Primary angiitis of the central nervous system vasculitis -- Relapsing polychondritis -- Cogan's syndrome.

Cruciferous vegetables and biological activity of isothiocyanates and indoles -- Green leafy vegetables in cancer prevention -- The role of tomato lycopene in cancer prevention -- [Beta]-carotene and other carotenoids in cancer prevention -- The role of alliums and their sulfur and selenium constituents in cancer prevention -- Molecular mechanisms of chemoprevention with capsaicinoids for chili peppers -- Influence of dietary soy isoflavones genistein and daidzein on genotoxicity and mammary carcinogenicity in rats exposed to the model carcinogen 7, 12-dimethylbenz[a]anthracene (DMBA) -- The potential roles of seeds and seed bioactives on the prevention and treatment of breast and prostate cancer -- Nuts as part of a whole diet approach to cancer prevention -- Whole grains and their constituents in the prevention of colon cancer.

Anatomy of the Myocardium in the Normal Left Ventricle --Normal Left Ventricular Dynamics: Contraction and Relaxation Patterns --Altered Left Ventricular Geometry in Ischemic Cardiomyopathy --Altered Ventricular Function in Ischemic Cardiomyopathy --Hemodynamics in Ischemic Cardiomyopathy: Left Ventricular Aneurysm Formation --Evolution of Techniques of Surgical Ventricular Restoration: From Linear Repair to Endoventricular Linear Patch Plasty --The Surgical Technique of Linear Endoventricular Patch Plasty --Surgical Ventricular Restoration by the Technique of Endoventricular Linear Patch Plasty: Long-Term Clinical Results --The Impact of Surgical Technique on Cardiac Hemodynamics Following Surgical Ventricular Restoration --Recent Controversies: To STICH or Not to STICH? --Role of Electrophysiological Testing, Intracardiac Defibrillator Implantation, and Concomitant Surgical Procedures in Patients with Left Ventricular Aneurysms Presenting with Ventricular Tachycardia --Role of Mitral Valve Surgery in Surgical Ventricular Restoration for Left Ventricular Aneurysms.

The human genome and its upcoming dynamics / M. Platzer -- Primate genomes / H. Herlyn, H. Zischler -- The mouse genome / S.D.M. Brown, J.M. Hancock -- The dog genome / F. Galibert, C. André -- The feline genome / W.J. Murphy -- The bovine genome / J.E. Womack -- The sheep genome / N.E. Cockett -- Cracking the genomic piggy bank : identifying secrets of the pig genome / B.E. Mote, M.F. Rothschild -- The horse genome / B.P. Chowdhary, T. Raudsepp -- Marsupial and monotreme genomes / E. Koina, J. Fong, J.A. Marshall Graves -- The chicken genome / D.W. Burt -- Insights from Xenopus genomes / N. Pollet, A. Mazabraud -- The Tetraodon genome / H. Roest Crollius -- The medaka genome : why we need multiple fish models in vertebrate functional genomics / H. Mitani ... [et al.] -- The zebrafish genome : a review and msx gene case study / J.H. Postlethwait -- Urochordate genomes / N. Satoh ... [et al.].

The Lancet: an introduction -- Vintage papers from The Lancet (1820s to 1860s from Wakley to Nightingle -- 1870s to 1910s from Bacteria to Blood Groups -- 1920s to 1950s from Iron Lungs to Ultrasound -- 1960s to 2005 from Thalidomide to SARS).

As natural as breathing : the flu virus -- Farming and feeding the hungry : plant viruses and human enteroviruses -- Raising cattle and eating meat : rinderpest, measles, and mad cow disease -- Slaking our thirst: the cholera bacteria and its toxic viruses -- Weathering storms and droughts : West Nile virus and others alike -- Getting lucky with a faulty gene : escape from simple retroviruses -- Taking chances with sex : the herpes and papova viruses -- Risking death with sex : the AIDS virus -- Warring against humans and other animals: smallpox, monkeypox and others -- Raiding the wild for delicacies : the SARS virus.

Viral genome packaging machines: an overview / Carlos Enrique Catalano -- Bacteriophage lambda terminase and the mechanisms of viral DNA packaging / Michael Feiss and Carlos Enrique Catalano -- DNA packaging in bacteriophage T4 / Venigalla B. Rao and Lindsay W. Black -- T3/T7 DNA packaging / Philip Serwer -- DNA packaging by bacteriophage P22 / Sherwood Casjens and Peter Weigele -- Bacteriophage SPP1 DNA packaging / Anja Dröge and Paulo Tavares -- The phi 29 DNA packaging motor : seeking the mechanism / Dwight Anderson and Shelley Grimes -- Encapsidation of the segmented double-stranded RNA genome of bacteriophage f6 / Minna M. Poranen, Markus J. Pirttimaa, and Dennis H. Bamford -- Cleavage and packaging of herpes simplex virus 1 DNA / Joel D. Baines and Sandra K. Weller.

Diagnosis and testing -- How is HCV spread from one person to another? -- Pregnancy and breast feeding -- Counseling -- Long-term consequences of HCV infection -- Management and treatment of chronic hepatitis C -- Genotype -- Hepatitis C and healthcare workers.