Books

all 250 "U" titles

U

  • pt. A-B, 2005. ScienceDirect
    pt. B ScienceDirect
    edited by Raymond J. Deshaies.
    Also available: Print – pt. A-B, 2005.
  • 2012 Springer Protocols
    edited by R. Jürgen Dohmen, Martin Scheffner.
  • 2009/2010
    Ivette Shiba Estay.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    volume editor, Stefan Jentsch, Bernhard Haendler.
  • 2005 Springer Protocols
    edited by Cam Patterson, Douglas M. Cyr.
    Assays of proteasome-dependent cleavage products / Stefan Tenzer and Hansjörg Schild -- Identification of components of protein complexes / Carol E. Parker ... [et al.] -- Mass spectroscometric determination of protein ubiqitination / Carol E. Parker ... [et al.] -- Reconstitution of endoplasmic reticulum-associated degradation using yeast membranes and cytosol / Robert J. Lee, Ardythe A. McCracken, and Jeffrey L. Brodsky -- Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation / Eric Carlson ... [et al.] -- Deubiquitinating enzyme purifucation, assay inhibitors and characterization / Nathaniel S. Russell and Keith D. Wilkinson -- Measuring ubiquitin conjugation in cells / Edward G. Mimnaugh and Leonard M. Neckers -- Assays for proteasome assembly and maturation / R. Jürgen Dohmen ... [et al.] -- N-terminal ubiquitination / Aaron Ciechanover -- Quantitating defective ribosome products / Shu-Bing Qian, Jack R. Bennink, and Jonathan W. Yewdell -- Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis / Antje Schäfer and Dieter H. Wolf -- Endoplasmic reticulum-associated protein quality control and degradation: genome wide screen for ERAD components / Antje Schäfer and Dieter H. Wolf -- Cystic fibrosis transmembrane conducatance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells / J. Michael Younger ... [et al.] -- Aggresome formation / Michael J. Corboy, Philip J. Thomas, and W. Christian Wigley -- Detection of sumoylated proteins / Roland S. Hilgarth and Kevin D. Sarge -- Proteasome inhibitors in cancer therapy / Robert Z. Orlowski -- Parkinson disease: assays for the ubiquitin ligase activity of neural parkin / Michael G. Schlossmacher and Hideki Shimura. Small-molecule inhibitors of proteasome activity / Maria Gaczynska and Pawel A. Osmulski -- Purification of E1 and E1-like enzymes / Arthur L. Haas -- Assays for RING family ubiquitin ligases / Manabu Furukawa, Paul S. Andrews, and Yue Xiong -- Ubiquitin chain synthesis / Shahri Raasi and Cecile M. Pickart -- Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast / David S. Leggett, Michael H. Glickman, and Daniel Finley -- Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome / Chang-Wei Liu ... [et al.] -- Cell-free assay for ubiquitin-independent proteasomal protein degradation / Chaim Kahana and Yuval Reiss --
  • Hasman, Arie.
    Status: Not Checked OutLane Catalog Record
  • 2009 ScienceDirect
    2009 Knovel
    editor, Steven M. Kurtz.
    A primer on UHMWPE / Steven M. Kurtz -- From ethylene gas to UHMWPE component : the process of producing orthopedic implants / Steven M. Kurtz -- Packaging and sterilization of UHMWPE / Steven M. Kurtz -- The origins of UHMWPE in total hip arthroplasty / Steven M. Kurtz -- The clinical performance of UHMWPE hip replacements / Steven M. Kurtz -- Contemporary total hip arthoplasty : hard-on-hard bearings and highly crosslinked UHMWPE / Steven M. Kurtz, Kevin Ong -- The origins and adaptations of UHMWPE for knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in shoulder replacements / Stefan M. Gabriel -- The clinical performance of UHMWPE in elbow replacements / Judd S. Day -- Applications of UHMWPE in total ankle replacements / Allyson Ianuzzi, Chimba Mkandawire -- The clinical performance of UHMWPE in the spine / Steven M. Kurtz, Marta L. Villarraga, Allyson Ianuzzi -- Highly crosslinked and melted UHMWPE / Orhun K. Muratoglu -- Highly crosslinked and annealed UHMWPE / John H. Dumbleton, Aiguo Wang, Kate Sutton ...[et al.] -- Highly crosslinked UHMWPE doped with vitamin E / Ebru Oral, Orhun K. Muratoglu -- Vitamin-E-blended UHMWPE biomaterials / Steven M. Kurtz, Pierangiola Bracco, Luigi Costa -- Composite UHMWPE biomaterials and fibers / Steven M. Kurtz -- UHMWPE / hyluronan microcomposite biomaterials / Susan P. James, Rachel (Kurkowski) Oldinski, Min Zhang ...[et al.] -- High pressure crystallized UHMWPEs / Anuj Bellare, Steven M. Kurtz -- Compendium of highly crosslinked UHMWPEs / Steven M. Kurtz -- Mechanisms of crosslinking, oxidative degradation and stabilization of UHMWPE / Luigi Costa, Pierangiola Bracco -- In vivo of UHMWPE / Steven M. Kurtz -- Pathophysiologic reactions to UHMWPE wear particles / Marla J. Steinbeck, Ryan M. Baxter, Theresa A. Freeman -- Characterization of physical, chemical, and mechanical properties of UHMWPE / Stephen Spielgelberg -- Tribological assessment of UHMWPE in the hip / Aaron Essner MS, Aiguo Wang -- Tribological assessment of UHMWPE in the knee / Hani Haider -- Characterization of UHMWPE wear particles / Tipper JL., Richards L., Ingham E. ...[et al.] -- Clinical surveillance of UHMWPE using radiographic methods / Charles R. Bragdon -- ESR insights into macroradicals in UHMWPE / M. Shah Jahan -- Fatigue and fracture of UHMWPE / Francisco J. Medel, Jevan Furmanski -- Development and application of the notched tensile test to UHMWPE / Michael C. Sobieraj, Clare M. Rimnac -- Development and application of the small punch test to UHMWPE / Avram A. Edidin -- Nano- and microindentation testing of UHMWPE / Jeremy L. Gilbert, James D. Wernle -- MicroCT analysis of wear and damage in UHMWPE / Daniel MacDonald, Anton Bowden, Steven M. Kurtz -- Computer modeling and simulation of UHMWPE / Anton E. Bowden, Erin Oneida, Jorgen Bergström.
  • 2005- Wiley
    Ullmann, Fritz.
    Covers science and technology in all areas of industrial chemistry, containing nearly 1000 major articles with more than 16 million words, nearly 10,000 tables, 30,000 figures, and literature sources and cross-references. It also includes full text index, author index, CAS registry number index, and keyword index.
  • 2007
    [edited by] Brian Freeman.
    Status: Not Checked OutLane Catalog Record
  • 2013 AccessMedicine
    [edited by] Brian S. Freeman.
    Online 3rd edition inlcudes only selected chapters as of 1/10/2014.
  • Koushik Shaw.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    Pierre-Marie Robitaille, Lawrence Berliner [eds.].
  • 2012
    Thomas Patrick Niedringhaus.
    Since the 2003 completion of the human genome by means of the Sanger-based DNA sequencing strategy and capillary array electrophoresis, the scientific and medical community has worked to make personalized medicine a reality. Next-generation DNA sequencing technologies with astoundingly high throughput are now in use and have provided exciting new capabilities. However, next-generation instruments are currently incapable of providing highly accurate, long sequencing read lengths, have difficulty sequencing through repetitive sequences, and have yet to "scale down" well for point-of-care diagnostics. The 600 to 700 base read lengths at 98% accuracy that are provided by capillary electrophoresis and the Sanger method are still the gold standard for medical sequencing. In recent years, there has been a natural progression from CAE to microchip electrophoresis. Microchip electrophoresis provides highly accurate sequencing at a small compromise to read length (~ 500 to 600 bases) while offering the potential for a significant increase in throughput due to the reduced separation times and the possibility to create a lab-on-a-chip (LOC) device that integrates upstream sample preparation steps. These advantages render CAE and microchip electrophoresis platforms desirable for clinical diagnostic tests since they offer highly accurate sequencing needed to analyze medically relevant genes and precisely genotype forensic samples. Therefore, this work focuses on understanding variables that influence the migration mechanism of single-stranded DNA (ssDNA) through physically- entangled polymer matrices used in CAE and microchip electrophoresis in an effort to increase throughput and bridge the gap for clinical adoption. First, I discuss the application of the biased reptation model (BRM) to CAE sequencing separations. In this study, I report the synthesis and characterization of an ultra-high molar mass linear polyacrylamide (LPA) to be used as a replaceable, physically-entangled polymer matrix and the migration mechanisms of ssDNA through the LPA matrices are evaluated using reptation plots. Properties of the LPA matrices (i.e. average pore size and viscosity) is tuned by the overall polymer concentration as well as mixing ultra-high and low molar mass LPA. In the end, a blended LPA solution generates a dynamically responsive polymer matrix that increases sequencing read lengths by delaying the onset of oriented biased reptation. The near-optimal blended LPA matrix which extends average read lengths to 830 bases in ~1 hour on a high-throughput CAE instrument. This represents a performance that is substantially better than the best commercial instrument/matrix CAE system available, which takes 2 hours to produce 830 bases. This was achieved by matrix optimization only. Second, I discuss transient effects on the DNA sequencing read length caused by shear-induced LPA stretching during the pressure-induced capillary loading of the polymer matrix which results in entanglement inhomogeneity. The network inhomogeneity, in turn, increases peak widths due to mobility variation among ssDNA fragments in the radial direction of the microchannel. The contributions of the matrix rheological properties, microchannel dimensions, and loading pressure to the shear forces placed on the matrix during loading are thoroughly examined. Finally, tests were carried out on microfluidic chips to reduced polymer network disruption. In the end, the loading conditions were optimized to enable loading and unloading of a sequencing matrix in less than 1 minute that also provides sequencing read lengths on the order of 550 to 600 bases in ~ 8 minutes. These results provide universal parameters for high-throughput loading of polymer matrices into capillaries and microchips used in electrophoretic genotyping assays and newly invented LOC platforms, such that the performance of the matrix will be optimal.
  • 2008
    Simone Sigrid Marticke.
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    Markus Braun, Peter Gilch, Wolfgang Zinth (eds.).
    Ultrahigh-resolution optical coherence tomography using femtosecond lasers / J. G. Fujimoto ... [et al.] -- Two-photon laser scanning microscopy / A. Nimmerjahn, P. Theer, F. Helmchen -- Femtosecond lasers in ophthalmology: surgery and imaging / J. F. Bille -- Ultrafast peptide and protein dynamics by vibrational spectroscopy / P. Hamm -- Photosynthetic light-harvesting / T. Pullerits, T. Polivka, V. Sundström -- Primary photosynthetic energy conversion in bacterial reaction centers / W. Zinth, J. Wachtveitl -- Ultrafast primary reactions in the photosystems of oxygen-evolving organisms / A. R. Holzwarth -- Primary photochemistry in the photoactive yellow protein: the prototype xanthopsin / D. S. Larsen, R. van Grondelle, K. J. Hellingwerf -- Structure based kinetics by time-resolved X-ray crystallography / M. Schmidt -- Primary reactions in retinal proteins / R. Diller -- Ultrashort laser pulses in single molecule spectroscopy / E. Houstein, P. Schwille.
  • 2015 Cambridge
    edited by Botros R.M.B. Rizk, MD, FRCOG, FACOG, HCLD, FACS, FRCS(C), Professor of Obstetrics and Gynecology and Director of the Division of Reproductive Endocrinology and Infertility, University of South Alabama College of Medicine, Mobile, AL, USA, President Elect, Middle East Fertility Society, Elizabeth E. Puscheck, MD, MS, FACOG, Professor and Chair of the Department of Obstetrics and Gynecology, Director of Gynecologic Ultrasound, Wayne State University Medical School, Detroit, MI, USA.
    Section 1. Techniques -- Section 2. Benign gynecology -- Section 3. Ectopic pregnancy -- Section 4. Gynecologic neoplasia -- Section 5. Ultrasonography in infertility.
  • 2008
    [edited by] Peter W. Callen.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Paula Ferrada, editor.
    I. Basics of Ultrasound -- 1. The Machine -- 2. Frequency and probes -- 3. Common Artifacts -- 4. The Doppler Effect -- II. Thoracic Ultrasound -- 5. The Pleura -- 6. The Lung -- 7. Procedures -- 8. Cases -- III. Echocardiogram for the Intensivist -- 9. Rationale -- 10. Limited echocardiogram vs. full service echo -- 11. The Windows -- 12. The Measurements -- 13. The interpretation -- 14. Cases -- IV. Vascular Ultrasound in the Critically Ill -- 15. Deep Venous Thrombosis -- 16. Line Placement -- 17. Cases -- V. Basic Abdominal Ultrasound in the ICU -- 18. Evaluation for free fluid -- 19. Basic Renal ultrasound -- 20. Evaluation of the Gallbladder -- 21. Procedures -- 22. Cases -- VI. Soft Tissue -- 23. Facial Dehiscence -- 24. Soft tissue masses and collections -- VII. Other Issues -- 25. Training Challenges -- 26. Credentialing Process -- 27. Billing and Coding.
  • 2011 Springer
    Wilhelm Schäberle.
    Fundamental principles -- Peripheral arteries -- Peripheral veins -- Shunts -- Extracranial cerebral arteries -- Visceral and retroperitoneal vessels -- Penile and scrotal vessels.
  • 2012 Springer
    Mirko D'Onofrio [editor] ; foreword by Claudio Bassi, Paolo Pederzoli.
    Ultrasound Imaging / Anna Gallotti and Fabrizio Calliada -- Transabdominal Ultrasonography of the Pancreas / Elisabetta Buscarini and Salvatore Greco -- Endoscopic Ultrasonography of the Pancreas / Elisabetta Buscarini and Stefania De Lisi -- Percutaneous Ultrasound Guided Interventional Procedures in Pancreatic Diseases / Elisabetta Buscarini and Guido Manfredi -- Intraoperative Ultrasonography of the Pancreas / Mirko D'Onofrio, Emilio Barbi, Riccardo De Robertis, Francesco Principe and Anna Gallotti, et al. -- Pancreatic Anatomy, Variants and Pseudolesions of the Pancreas / Emilio Barbi, Salvatore Sgroi, Paolo Tinazzi, Stefano Canestrini and Anna Gallotti, et al. -- Pancreatitis and Pseudocysts / Steffen Rickes and Holger Neye -- Solid Pancreatic Tumors / Christoph F. Dietrich, Michael Hocke, Anna Gallotti and Mirko D'Onofrio -- Cystic Pancreatic Tumors / Mirko D'Onofrio, Paolo Giorgio Arcidiacono and Massimo Falconi -- Rare Pancreatic Tumors / Roberto Malagò, Ugolino Alfonsi, Camilla Barbiani, Andrea Pezzato and Roberto Pozzi Mucelli -- Imaging Correlation / Marie-Pierre Vullierme and Enrico Martone -- Pancreatic Lesions: Pathologic Correlations / Paola Capelli and Alice Parisi -- Clinical and Imaging Scenarios / Anna Gallotti and Riccardo Manfredi -- Flowcharts in Pancreatic Diseases / Elisabetta Buscarini.
  • 2014 Springer
    Ferdinando Draghi.
    This practice-oriented book, containing a wealth of high-quality ultrasound images, provides clear, concise, and complete coverage of the normal anatomy of the hand and wrist - tendons, nerves, and vascular structures - as well as the main pathologic conditions encountered in this area. The ultrasound images have been acquired with state of the art scanners and carefully labeled to facilitate recognition of each and every anatomic structure. Helpful comparison is also made with images and findings obtained using other diagnostic techniques, including in particular magnetic resonance imaging. The lucid text is complemented by practical tables summarizing key points for ease of reference. Readers will find Ultrasonography of the Upper Extremity to be a rich source of information on anatomy, examination techniques, and ultrasound appearances of one of the anatomic regions to have benefited the most from the technological revolution that has taken place in the field of ultrasonography during recent years. The book will appeal to both novice and experienced practitioners, including above all radiologists and ultrasound technicians but also rheumatologists and orthopedic surgeons.
  • 2015 Springer
    Enzo Silvestri, Alessandro Muda, Davide Orlandi ; foreword by Nicola Maffulli.
    The book provides a comprehensive description of the basic ultrasound principles, normal anatomy of the lower limb muscles and classification of muscle strain injures. Ultrasound images are coupled with anatomical schemes explaining probe positioning and scanning technique for the various muscles of the thigh and leg. For each muscle, a brief explanation of normal anatomy is also provided, together with a list of tricks and tips and advice on how to perform the ultrasound scan in clinical practice. This book is an excellent practical teaching guide for beginners and a useful reference for more experienced sonographers.
  • 2012 Springer
    Andrew Nicolaides, Kirk W. Beach, Efthyvoulos Kyriacou, Constantinos S. Pattichis, editors.
  • 2010 Springer
    by Vladimir P. Kharchenko, Peter M. Kotlyarov, Mikhail S. Mogutov, Yury K. Alexandrov, Alexander N. Sencha, Yury N. Patrunov, Denis V. Belyaev.
    As the basis for this book, the authors have analyzed more than 100,000 ultrasound examinations performed between 1995 and 2008 in patients with thyroid and parathyroid disease, as well as many thousands of diagnostic and therapeutic ultrasound-guided minimally invasive procedures. The opening chapters include discussion of current ultrasound techniques, pitfalls, and ultrasound examination of the thyroid in children. Detailed attention is then devoted to findings in the normal thyroid and in the presence of diffuse and focal changes.
  • 2012 Springer
    João Miguel Sanches, Andrew F. Laine, Jasjit S. Suri, editors.
    Ultrasound Imaging: Advances and Applications presents some of the recent advances in Ultrasound imaging technology covering several organs and techniques in a Biomedical Engineering (BME) perspective. The focus of the book is in the algorithms, methodologies and systems developed by multidisciplinary research teams of engineers and physicians for Computer-Aided Diagnosis (CAD) purposes. Cardiovascular and Cancer, the most common life-threatening diseases in western countries, are two of the most important topics focused in the book. However, other advanced issues are also presented such as Intravascular Ultrasound, 3D US and Ultrasound in Computer-Aided Surgery (CAS). Some chapters are direct contributions from medical research groups where Ultrasound has also received great attention in the last decade. By this, new techniques based on Ultrasound were introduced in the clinical practice for diagnosis and therapeutics, mainly in hospital facilities.
  • 2016 Karger
    volume editors Mario Meola, Ilaria Petrucci, Claudio Ronco.
    Pathophysiology and clinical work-up of acute kidney injury / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Ultrasound in acute kidney disease / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : pre-renal acute kidney injury / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : hepato-renal syndrome / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : parenchymal acute kidney injury tubulo-interstitial diseases / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Clinical scenarios in acute kidney injury-parenchymal acute kidney injury, vascular diseases / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Clinical scenarios in acute kidney injury : post-renal acute kidney injury / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Imaging in chronic kidney disease / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : vascular chronic diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : parenchymal chronic renal diseases, part 1 / Petrucci, I., Samoni, S., Meola, M -- Clinial scenarios in chronic kidney disease : parenchymal chronic renal diseases, part 2 / Petrucci, I., Samoni, S., Meola, M -- Clinical scenarios in chronic kidney disease : chronic tubulointerstitial diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : cystic renal diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : kidneys' structural changes in end stage renal disease / Meola, M., Samoni, S., Petrucci, I.
  • 2014 Springer
    Laurel A. Stadtmauer, Ilan Tur-Kaspa, editors.
    Part I: Ultrasound Technique -- Ultrasound in Reproductive Medicine: Is It Safe?- Principles of 3D Ultrasound -- Two Dimensional and Three Dimensional Doppler in Reproductive Medicine -- Legal Aspects of Ultrasound Imaging in Reproductive Medicine -- Part II: Ultrasound in Infertility Workup -- The Normal Ovary -- Ovarian Reserve and Ovarian Cysts -- Ultrasound and PCOS -- The Normal Uterus -- Congenital Uterine Anomalies -- Uterine Fibroids -- Endometrial Polyps -- Intrauterine Adhesions -- Sonohysterography (SHG) in Reproductive Medicine -- Evaluation of Tubal Patency (HyCoSy, Doppler) -- Hydrosalpinx -- Virtual Hysterosalpingography: A New Diagnostic Technique for the Study of the Female Reproductive Tract -- Ultrasound in Male Infertility -- Part III: Ultrasound in Infertility Treatment -- Ultrasound in Follicle Monitoring for Ovulation Induction/IUI -- 2D Ultrasound in Follicle Monitoring for ART -- 3D Ultrasound in Follicle Monitoring for ART -- Ultrasound Guided Surgical Procedures -- Ultrasound Role in Embryo Transfers -- Ultrasound and Ovarian Hyperstimulation Syndrome -- Pregnancy of Unknown Viability -- Ultrasound Evaluation of Ectopic Pregnancy -- Focused Ultrasound for Treatment of Fibroids.
  • 2007
    Ilan E. Timor-Tritsch, Steven R. Goldstein.
    Status: Not Checked OutLane Catalog Record
    Ultrasound in gynecology: development and continuing evolution -- Applied physics: selecting and adjusting the equipment -- Instrumentation, modality selection, and documentation -- Conducting the gynecologic ultrasound examination -- Relevant pelvic anatomy -- Adenomyosis -- Congenital uterine anomalies -- Adnexal masses -- Menopausal dilemmas: how ultrasound has changed clinical management -- Lower urinary tract -- Early pregnancy -- Pregnancy failure -- Ectopic pregnancy -- Infertility -- Sonohysterography -- Ultrasound-guided procedures in gynecology -- Color doppler mapping in gynecology -- Transvaginal sonography and ovarian cancer -- Three-dimensional ultrasound in gynecology -- Ultrasound-enhanced bimanual examination -- Differential diagnosis of inflammatory diseases of the pelvis -- Pearls and pitfalls of transvaginal sonography.
  • 2005 Thieme Book
    [edited by] Eberhard Merz ; contributors F. Bahlmann ... [et al.]; [translator, Terry Telger].
    v. 1: Obstetrics
    Also available: Print – v. 1-, 2005-
  • 2015 Springer
    Matthew Jankowich, Eric Gartman, editors.
    Ultrasound in the Intensive Care Unit explores the current state of evidence supporting use of bedside ultrasound for procedural guidance and for the critical care-focused assessment of a variety of organ systems. This text covers standard practice areas, such as ultrasound guidance for vascular access in the ICU, as well as novel, less well-known applications such as the use of ultrasound for assessment of diaphragm function in patients with respiratory failure. As current ultrasound education is often dependent on widely varying local expertise, this book serves as a standard reference in what is at present a fragmented and challenging field of study for busy clinicians. By providing a comprehensive overview of the current state of critical care ultrasonography, with content contributed by experts in the field, this text will serve as a valuable resource that will allow education in critical care ultrasound to keep pace with the rapid technological growth that has driven this vital area of critical care medicine. Ultrasound in the Intensive Care Unit is essential reading for pulmonologists, practitioners in internal, hospitalist, and critical care medicine; educators and instructors in critical care ultrasound; and medical students, residents, and critical care trainees.
  • 2013
    Randy L. King.
    Ultrasound-induced neurostimulation has recently gained increasing attention. Developments in the use of ultrasound to stimulate and modulate neural activity have raised the possibility of using ultrasound as a new investigative and therapeutic tool in brain research. Little is known about the mechanisms by which it affects neural activity or about the range of acoustic parameters and stimulation protocols that elicit responses. In this thesis, conditions are established for transcranial stimulation of the nervous system in vivo, using the mouse somatomotor response. It is reported that (1) continuous-wave stimuli are as effective as or more effective than pulsed stimuli in eliciting responses, and responses are elicited with stimulus onset rather than stimulus offset; (2) stimulation success increases as a function of both acoustic intensity and acoustic duration; (3) interactions of intensity and duration suggest that successful stimulation results from the integration of stimulus amplitude over a time interval of 50 to 150 ms; (4) the motor response elicited appears to be an all-or-nothing phenomenon, meaning stronger stimulus intensities and durations increase the probability of a motor response without affecting the duration or strength of the response; and (5) motor responses, measured by normalized EMG signals in the neck and tail regions, change signifcantly when sonicating rostral and caudal regions of the mouse motor cortex. Taken together our findings present good evidence for being able to target selective parts of the motor cortex with ultrasound neurostimulation in the mouse, steps that should provide encouragement for the development of new applications in larger animal models, including humans.
  • 2008 ClinicalKey
    Beryl R. Benacerraf.
    This book on prenatal diagnosis details the most common sonographically detectable fetal syndromes. It has an easy-to-follow approach of using lists and patterns of malformations to generate a differential diagnosis of the possible syndrome involved. The reader is then led to the more detailed description of each syndrome to determine the exact final diagnosis. The new edition incorporates 3D ultrasound throughout the book, as well as 20 syndromes not previously covered.
  • 2007 Springer
    G. Maconi, G. Bianchi Porro (eds.) ; with contributions by G. Bianchi Porro ... [et al.] ; foreword by A.L. Baert.
  • 2014 Springer
    Giovanni Maconi, Gabriele Bianchi Porro, editors.
    This is the second, updated and extended edition of a well-received book that offers a comprehensive overview of ultrasonographic imaging of acute and chronic gastrointestinal diseases, including acute abdomen, appendicitis, diverticulitis, inflammatory bowel diseases, neoplasms and masses, infections, malabsorption syndromes, and rare conditions. The value of ultrasound in each disorder is clearly explained and illustrated, and limitations identified. Information is also provided on recent technical developments and ultrasound applications that are likely to become of increasing importance, such as functional and 3D ultrasound, contrast agents and intraoperative ultrasound, elastography, and transperineal ultrasound. The authors are all distinguished experts in the topics they address. Ultrasound of the Gastrointestinal Tract will be a helpful guide in daily practice not only for radiologists but also for gastroenterologists, abdominal surgeons, pediatricians, and oncologists.
  • 2015 Springer
    Bruce R. Gilbert, editor.
    History of Ultrasound -- Embryology Relevant to Ultrasound Imaging of the Male Genitalia -- Physical Principles of Ultrasound of the Male Genitalia -- Scrotal Ultrasound -- Penile Ultrasound -- Urology Ultrasound Practice Accreditation -- Genital Ultrasound Protocols: Putting it all Together!.
  • 2007 Springer
    Stefano Bianchi, Carlo Martinoli [editors] ; with contributions by L.E. Derchi ... [et al.] ; foreword by A.L. Baert ; introduction by I.F. Abdelwahab.
  • 2012 Springer
    Robert A. Sofferman, Anil T. Ahuja, editors.
    Section I. History and Basic Concepts -- The History of Clinical Ultrasound -- Physics and Principles of Ultrasound -- Practical Concepts of Ultrasound -- Section II. Thyroid and Parathyroid Glands -- Sonography of the Normal Thyroid -- Benign Thyroid Conditions -- Malignant Thyroid Conditions -- Ultrasound Surveillance -- Parathyroid Ultrasound -- Fine Needle Aspiration Cytology -- Section III. Lymph Nodes and the Neck -- Lymph Nodes -- Benign Clinical Conditions in the Adjacent Neck -- Section IV. New Advances in Applied Ultrasound -- Thyroid Elastography -- Percutaneous Ethanol Injection for Thyroid and Parathyroid Disorders -- Contrast Enhanced Ultrasound and Ultrasound-Guided Minimally Invasive Therapy for the Diagnosis and Treatment of Focal Thyroid Lesions.
  • 2006 Thieme Book
    [edited by] Grant M. Baxter, Paul S. Sidhu ; with contributions by P.L. Allan [and others].
    Nephrology -- Introduction: medical overview -- Normal kidney -- Parenchymal diseases of the kidney -- Chronic renal failure -- Renal transplantation -- Radiological intervention in the urogenital tract (including trauma and emergencies) -- Urology -- Urogenital tract: surgical overview -- Focal lesions of the kidney -- Diseases of the collecting system and ureters -- Diseases of the bladder and prostate -- Diseases of the testis and epididymis -- Diseases of the penis with functional evaluation -- Oncological management of tumors of the urogenital tract -- Urogenital tract in the child -- Ultrasound of the pediatric urogenital tract -- Other imaging modalities in the urogenital tract -- Non-ultrasound imaging of the urogenital tract -- New developments: ultrasound contrast agents -- Native kidney -- Transplant kidney.
  • 2007 Thieme Book
    [edited by] Günter Schmidt ; with contributions by B. Beuscher-Willems ... [et al.] ; [translator, Terry Telger].
    Basic physical and technical principles -- The ultrasound examination -- Ultrasound documentation and reporting -- Function studies -- Interventional ultrasound -- Principal signs and symptoms -- Arteries and veins -- Cervical vessels -- Liver -- Kidney and adrenal gland -- Pancreas -- Spleen -- Bile ducts -- Gallbladder -- Gastrointestinal tract -- Urogenital tract -- Thorax -- Thyroid gland -- Major salivary glands -- Postoperative ultrasound -- Search for occult tumors.
  • 2016 ClinicalKey
    Barbara S. Hertzberg, William D. Middleton.
    This best-selling volume in The Requisites Series provides a comprehensive introduction to timely ultrasound concepts, ensuring quick access to all the essential tools for the effective practice of ultrasonography. Comprehensive yet concise, Ultrasound covers everything from basic principles to advanced state-of-the-art techniques. This title perfectly fulfills the career-long learning, maintenance of competence, reference, and review needs of residents, fellows, and practicing physicians. Covers the spectrum of ultrasound use for general, vascular, obstetric, and gynecologic imaging.
  • 2014 Springer
    Guido Torzilli, editor.
    Ultrasound guidance of liver surgery is a very sophisticated approach that permits the performance of otherwise unfeasible operations, discloses the true extent of tumors, increases the indications for hepatectomy, and renders surgery safer. Despite this, it has remained relatively neglected in the literature over the past two decades, during which time much progress has been achieved. This is the first atlas on the subject, and it is comprehensive in scope. The state of the art in the use of ultrasound for resection guidance is carefully documented, and new techniques for exploration of the biliary tract and facilitation of transplant surgery are presented. Further important topics include the role of ultrasound in laparoscopic approaches, the use of contrast agents for diagnosis and staging, and developments in the planning of surgical strategy. The editor is a leading authority whose group has been responsible for a variety of advances in the field. He has brought together other experts whose aim throughout is to provide clear information and guidance on the optimal use of ultrasound when performing liver surgery. This atlas is intended especially for hepatobiliary surgeons but will also be of considerable value for general surgeons.
  • 2015 Springer
    Luca Maria Sconfienza, Davide Orlandi, Enzo Silvestri, editors.
  • 2012 Springer
    Luca Maria Sconfienza, Giovanni Serafini, Enzo Silvestri, editors.
    pt. 1. General Aspects of US-guided Musculoskeletal Procedures -- General Aspects of US-guided Musculoskeletal Procedures / Armando Conchiglia, Lorenzo Maria Gregori, Luigi Zugaro and Carlo Masciocchi -- pt. I. The Shoulder -- The Shoulder: Focused US Anatomy and Examination Technique / Enzo Silvestri and Davide Orlandi -- Subacromial-Subdeltoid Bursa Injections / Enzo Silvestri -- Treament of Calcific Tendinitis of the Rotator Cuff / Giovanni Serafini and Luca Maria Sconfienza -- Calcific Enthesopathy Dry-Needling / Francesca Lacelli -- Hyaluronic Supplementation of the Subacromial Space / Giovanni Serafini -- Intra-articular Injections / Francesca Lacelli -- Long Head of the Biceps Brachii Tendon Injection / Luca Maria Sconfienza -- Acromioclavicular Joint Injection / Enzo Silvestri -- pt. II. The Elbow -- The Elbow: Focused US Anatomy and Examination Technique / Enzo Silvestri and Emanuele Fabbro -- Treatment of Lateral Epicondylitis / Giovanni Serafini -- Treatment of Medial Epicondylitis / Enzo Silvestri -- Olecranon Bursa Drainage / Francesca Lacelli -- Intra-articular Injections / Luca Maria Sconfienza -- pt. III. The Wrist -- The Wrist: Focused US Anatomy and Examination Technique / Enzo Silvestri and Giulio Ferrero -- Treament of De Quervain's Disease and Other Forms of Tenosynovitis / Giovanni Serafini -- Articular Ganglia Drainage / Leonardo Callegari -- Trapeziometacarpal Joint Injection / Francesca Lacelli -- Radiocarpal Joint Injections / Luca Maria Sconfienza -- pt. IV. The Hand -- The Hand: Focused US Anatomy and Examination Technique -- Francesca Lacelli and Chiara Martini -- Treatment of Trigger Finger / Leonardo Callegari -- Intra-articular Injections: Metacarpophalangeal and Interphalangeal Joints / Luca Maria Sconfienza.
  • 2010 Thieme Book
    edited by Vikram S. Dogra, Wael E.A. Saad.
    This handbook is a practical reference for the full range of common and complex ultrasound-guided procedures frequently performed in clinical practice. Divided into four sections, this book provides in-depth guidelines from renowned specialists for how to perform ultrasound-guided biopsies, how to utilize ultrasound to obtain access for interventional procedures and perform drainage, and how to perform ultrasound-guided percutaneous therapy and sonohysterography. Detailed coverage of such key procedures as thyroid biopsy, breast biopsy, sonohysterography, superficial lymph node biopsy, musculoskeletal interventions, and more. Concise bullet-point format that aids rapid reading and review of indications, contraindications, equipment, technique and post-procedural evaluation and possible complications and their management. More than 600 high-quality images and illustrations that clarify complex concepts.
  • Ovid
    editors, Paul E. Bigeleisen, Michael Gofeld, and Steven L. Orebaugh ; associate editors, Nizar Moayeri, Annelot Krediet, Gerbrand J. Groen, Stephen Breneman, Bassem Asaad, and Jacques E. Chelly.
  • 2015 Cambridge
    edited by Stephen Mannion, Gabriella Iohom, Christophe Dadure, Mark Reisbig, Arjunan Ganesh.
    Performance of regional anesthesia in children / Arjunan Ganesh and Wallis T. Muhly -- Pharmacology of local anesthetics in children / Christina Van Horn and Mark D. Reisbig -- Management of complications / Immanuel Hennessy and Stephen Mannion -- Basics of ultrasonography for regional anesthesia in children / Christophe Dadure and Chrystelle Sola -- Anatomy of the neuraxis, thoracic, and abdominal walls, upper and lower limbs / Judith Barbaro-Brown and Gabriella Iohom -- Ultrasound guided axillary block in children / Pádraig O'Scanaill and Brian O'Donnell -- Ultrasound-guided supraclavicular brachial plexus block / Mark D. Reisbig -- Ultrasound guided infraclavicular brachial plexus block / Wallis T. Muhly and Arjunan Ganesh -- Ultrasound guided interscalene brachial plexus block / Harshad Gurnaney and Arjunan Ganesh -- Ultrasound guided femoral nerve block / Frédéric Duflo -- Ultrasound guided saphenous nerve block / Ahmed Abdel-Aziz and Amr Abdelaal -- Ultrasound guided sciatic nerve block / Anne-Charlotte Saour and Christophe Dadure -- Ultrasound guided ilioinguinal/iliohypogastric block / Sinead O'Shaughnessy and Charles Youngblood -- Transversus abdominis plane block / Eimhin Dunne and Brian O'Donnell -- Ultrasound guided rectus sheath block / Harshad Gurnaney and Arjunan Ganesh -- Ultrasound guided paravertebral block / Attila Bondár and Gabriella Iohom -- Ultrasound guided epidural anesthesia / Chrystelle Sola and Christophe Dadure -- Ultrasound for spinal anesthesia / Karthikeyan Kallidaikurichi Srinivasan and Peter Lee -- Ultrasound guided caudal block / Anca Grigoras and Jawad Mustafa -- Facial blocks / Chrystelle Sola and Christophe Dadure.
  • 2005 Karger
    Ann M. Dvorak.
    Also available: Print – 2005
  • 2016 Springer
    Giuseppe Biondi-Zoccai, editor.
    1 Evidence hierarchy -- 2 From qualitative reviews to umbrella reviews -- 3 Umbrella reviews, overviews of reviews, meta-epidemiologic studies: similarities and differences -- 4 Designing the review -- 5 Registering the review -- 6 Searching evidence -- 7 Abstracting evidence -- 8 Appraising evidence -- 9 Synthesizing evidence -- 10 Appraising moderators and confounders -- 11 State of the art reporting -- 12 Case study in anesthesiology and intensive care -- 13 Case study in basic research -- 14 Case study in cardiovascular disease -- 15 Case study in dermatology -- 16 Case study in oncology -- 17 Case study in radiology -- 18 Case study in surgery -- 19 Moving from evidence to action -- 20 Avenues for further research -- 21 Conclusion.
  • v. 2, 1953-.
    Neumann, Erich.
    Status: Not Checked OutLane Catalog Record
    -- v. 2. Zur Psychologie des Weiblichen.
  • 2006 CRCnetBASE
    Anthony J. Rhem.
  • 2013 ClinicalKey
    [edited by] Darcy Umphred [and others].
    Section I. Foundations for clinical practice in neurological rehabilitation. Foundations for clinical practice / Darcy A. Umphred, Rolando T. Lazaro and Margaret L. Roller -- Health and wellness: The beginning of the paradigm / Janet R. Bezner -- Movement analysis across the life span / Dale Scalise-Smith and Darcy A. Umphred -- Contemporary issues and theories of motor control, motor learning, and neuroplasticity / Margaret L. Roller ... [et.al.] -- The limbic system : Influence over motor control and learning / Darcy A. Umphred, Marcia Hall Thompson and Therese Marie West -- Psychosocial aspects of adaptation and adjustment during various phases of neurological disability / Rochelle McLaughlin and Gordon U. Burton -- Differential diagnosis phase 1 : Medical screening by the therapist / William G. Boissonnault and Darcy A. Umphred -- Differential diagnosis phase 2 : Examination and evaluation of functional movement activities, body functions and structures, and participation / Rolando T. Lazaro, Margaret L. Roller and Darcy A. Umphred -- Interventions for clients with movement limitations / Darcy A. Umphred ... [et.al.] -- Payment systems for services : Documentation through the care continuum / Barbara Edmison and John G. Wallace, Jr. -- Section II. Rehabilitation management of clients with neurological system pathology. Neonates and parents : Neurodevelopmental perspectives in the neonatal intensive care unit and follow-up / Jane K. Sweeney, Teresa Gutierrez and Joanna C. Beachy -- Management of clinical problems of children with cerebral palsy / Claudia R. Senesac -- Genetic disorders : A pediatric perspective / Sandra G. Bellamy and Eunice Yu Chiu Shen -- Learning disabilities and developmental coordination disorder / Stacey E. Szklut and Darbi Breath Philibert -- Spina bifida : A congenital spinal cord injury / Kristin J. Krosschell and Mari Jo Pesavento -- Traumatic spinal cord injury / Myrtice B. Atrice ... [et.al.] -- Neuromuscular diseases / Ann Hallum and Diane D. Allen -- Beyond the central nervous system : Neurovascular entrapment syndromes / Bradley W. Stockert, Laura J. Kenny and Peter I. Edgelow -- Multiple sclerosis / Gail L. Widener -- Basal ganglia disorders / Marsha E. Melnick -- Movement dysfunction associated with cerebellar damage / Susanne M. Morton and Amy J. Bastian -- Balance and vestibular dysfunction / Leslie K. Allison and Kenda Fuller -- Movement dysfunction associated with hemiplegia / Susan D. Ryerson -- Traumatic brain injury / Patricia A. Winkler -- Brain tumors / Corrie J. Stayner, Rachel M. Lopez and Karla M. Tuzzolino -- Inflammatory and infectious disorders of the brain / Judith A. Dewane -- Aging, dementia, and disorders of cognition / Osa Jackson Schulte, James Stephens and Joyce Ann -- Section III. Neurological disorders and applications issues. Disorders of vision and visual-perceptual dysfunction / Laurie Ruth Chaikin -- Pelvic floor treatment of incontinence and other urinary dysfunctions in men and women / Beate Carriere -- Cardiovascular and pulmonary system health in populations with neurological disorders / Marilyn Mackay-Lyons -- Human immunodeficiency virus infection : Living with a chronic illness / Kerri Sowers, Mary Lou Galantino and David M. Kietrys -- Pain management / Annie Burke-Doe -- Electrophysiological testing and electrical stimulation in neurological rehabilitation / Alain Claudel ... [et.al.] -- Orthotics : Evaluation, intervention, and prescription / Heidi Truman and Walter Racette -- Management of chronic impairments in individuals with nervous system conditions / Myla U. Quiben -- Impact of drug therapy on patients receiving neurological rehabilitation / Annie Burke-Doe and Timothy J. Smith -- Use of medical imaging in neurorehabilitation / Rolando T. Lazaro and Darcy A. Umphred -- Integrating technology into clinical practice in neurological rehabilitation / Katie Byl ... [et.al.] -- Complementary and alternative therapies : Beyond traditional approaches to intervention in neurological diseases and movement disorders / Darcy A. Umphred, Carol M. Davis and Mary Lou Galantino.
  • 2015 Springer
    Pierre Le Béguec, François Canovas, Olivier Roche, Mathias Goldschild, Julien Batard.
    Part I: Press-Fit Concept -- Uncemented Concepts: Parameters to Make a Choice -- The Press-Fit Concept: Principles and Press-Fittable Zones -- The Press-Fit Concept: Practical Application -- The Press-Fit Concept: Implants And Instruments -- Part II: Preoperative Planning -- Radiographic Analysis Of The Femur -- Selection of a Strategy -- Making a Preoperative Template -- Part III: Surgical Technique -- Trochantero-Diaphyseal Femoral Flap -- Femoral Flap and Diaphyseal Primary Fixation -- Endofemoral Approach and Proximal Primary Fixation -- Part IV: Evaluation of the Radiographic Results -- General Considerations -- A-Evaluation of the Radiographic Results ? How? -- Evaluation of Initial and Secondary Bone Stock -- Evaluation of Osseointegration and Secondary Stability -- Global Radiographic Score -- Comparative Elements with the Engh Score -- Part V: Evaluation of the Radiographic Results -- Why? -- The Learning Curve and its Teachings -- Different Types of Primary Stability: Their Impact on the Radiographic Results -- Degree of Osteoporosis: Its Impact on the Radiographic Results -- Affected Initial Bone Stock: Its Impact on the Radiographic Results -- Parameters to Improve Radiographic Results -- Complications and Contraindications -- Numerical Evaluation and Comparative Analysis of Results -- General Conclusions: What You Should and What You Should not Do.
  • 2008 WHO
    Part 1: Guidance document on characterizing and communicating uncertainty in exposure assessment -- Part 2: Hallmarks of data quality in chemical exposure assessment.
    Also available: Print – 2008
  • 2006 CRCnetBASE
    Bilal M. Ayyub, George J. Klir.
  • 2008
    edited by Louis R. Caplan ; founding editor, Julien Bogousslavsky.
  • 2014 Springer
    Marc Leone, Claude Martin, Jean-Louis Vincent, editors.
    This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.
  • 2013 Springer
    Paolo Pederzoli, Claudio Bassi, editors ; in collaboration with Massimo Falconi, Roberto Salvia and Giovanni Butturini ; foreword by Gianluigi Melotti.
    Cystic Pancreatic Neoplasms -- Classification / Giuseppe Zamboni -- Serous Cystic Neoplasms / Giuseppe Malleo, Giuseppe Zamboni, Marina Paini, Giovanni Marchegiani -- Mucinous Cystic Neoplasms / Giovanni Marchegiani, Riccardo Manfredi, Giuseppe Malleo, Isabella Frigerio -- Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms / Marina Paini, Giuseppe Zamboni, Riccardo Manfredi, Salvatore Paiella, Giuseppe Malleo -- Intraductal Papillary Mucinous Neoplasms / Isabella Frigerio, Giuseppe Zamboni, Riccardo Manfredi, Antonio Pea, Silvia Pennacchio -- The Role of the Oncologist in the Diagnosis and Management of Malignant Cystic Neoplasms / Alessandra Auriemma, Davide Melisi, Giampaolo Tortora -- Neuroendocrine Pancreatic Neoplasms -- Epidemiology and Clinical Presentation / Maria Vittoria Davì, Marco Toaiari, Giuseppe Francia -- Pathology and Genetics / Aldo Scarpa, Vincenzo Corbo -- Imaging / Roberto Pozzi Mucelli, Giovanni Foti, Luigi Romano -- Surgical Therapy / Rossella Bettini, Stefano Partelli, Stefano Crippa, Letizia Boninsegna, Massimo Falconi -- Functional Imaging and Peptide Receptor Radionuclide Therapy / Maria Chiara Ambrosetti, Duccio Volterrani, Federica Guidoccio, Lisa Bodei -- Targeted and Other Non-receptor-mediated Therapies / Sara Cingarlini, Chiara Trentin, Elisabetta Grego, Giampaolo Tortora -- Uncommon Pancreatic Solid Neoplasms -- Rare Variants of Ductal Adenocarcinoma of the Pancreas / Paolo Regi, Marco Dal Molin, Federica Pedica, Paola Capelli, Mirko D'Onofrio -- Rare Primary Tumors of the Pancreas / Marco Dal Molin, Paola Capelli, Mirko D'Onofrio, Ivana Cataldo, Giovanni Marchegiani -- Rare Secondary Tumors of the Pancreas / Giovanni Butturini, Marco Inama, Marco Dal Molin, Mirko D'Onofrio, Davide Melisi -- Primary Non-epithelial Tumors of the Pancreas / Marco Dal Molin, Paola Capelli -- Tumor-like Lesions of the Pancreas / Luca Frulloni, Antonio Amodio, Italo Vantini, Marco Dal Molin, Marco Inama.
  • 2012
    Jana Schaich Borg.
    Over half of all violent crimes are committed by only about 5% of offenders. While most healthy people feel strong aversion to seeing other people in pain, fear, or sadness, a phenomenon I define as "negative intersubjectivity", these persistent violent offenders (PVOs) have blunted reactions to other people's distress and the strength of their negative intersubjectivity deficit correlates with how much violence they ultimately perform. This suggests that if we could learn how to enhance PVOs aversion to other people's distress, we could decrease their violent behavior. In this dissertation, I describe a new rat model that can be used to study the neural mechanisms underlying negative intersubjectivity. I demonstrate that Observer rats will overcome their innate aversion of bright light to consistently avoid a dark, safe space if entering that dark space is paired with another Receiver rat getting shocked, a behavior called "intersubjective avoidance". In Chapter 2, I describe the relatively poor intersubjective avoidance behavior of mice. In Chapter 3, I describe the comparatively strong intersubjective avoidance behavior of rats, and show that rats' intersubjective avoidance is enhanced by personal experience with shock. In Chapter 4, I use patterns of expression of the immediate early gene c-Fos to determine whether activity in candidate brain regions correlates with intersubjective avoidance. I provide evidence that many brain regions--including the anterior cingulate, anterior insula, infralimbic cortex, and central amygdala--are active both when observing shock in another and when receiving shock to oneself, similar to what has been shown by fMRI studies of humans observing others in pain. However, within these areas, only activity in the anterior cingulate robustly correlates with how much intersubjective avoidance each individual Observer rat performs, perhaps analogous to how fMRI studies in humans have show that anterior cingulate activity correlates with humans' self-reports of "empathy". These results validate the rat model of intersubjective avoidance as model of negative intersubjectivity in humans, and highlight the anterior cingulate as a potential target for negative intersubjectivity interventions. In Chapter 5, I describe future experiments and discuss how research using this new behavioral paradigm may help develop treatments for not only PVOs, but all anti-social behavior.
  • 2012
    Ekaterina Neklyudova.
    My dissertation deals with the figure of the doctor in early Russian nineteenth-century prose, which manifests a shift in the way literature depicts human physicality and the characters' everyday life. My major source is 1820s-1840s prose, mostly published in the literary and cultural journals Biblioteka dlia Chtenia, Syn Otechestva, and others. My sources reflect the impressive expansion in Russian literature and medicine in the first quarter of the nineteenth century. Using documentary and literary sources, I demonstrate that the artistic representation of physicians in Romantic and Realist prose contributes to the introduction of previously unknown themes into literature: medical perspectives on physical suffering, the private everyday lives of ordinary people, and even the mystical view of other worlds. The combination of medical and mystical discourses in the vocabulary of real doctors in the first half of the nineteenth century gave them the authority to judge human bodies, lives, and, they believed, souls: they seemed to observe from inside and outside at the same time. By including a doctor among their characters, fiction writers thus could use a powerful instrument that let them introduce new topics. As I show, through the mid nineteenth century, the fictional doctors situated at the margin of literary plots performed the role of an important textual device: they served as go-betweens among other characters, mediating, connecting or splitting them. They affected the relationship between characters, the plot's trajectory, and the readers' perception. The situation shifts in mid century; with the gradual separation of doctor from his instrumental function, this character moves to the center of the plot and loses his structural power.
  • 2016 Springer
    Michael B. Chancellor, Ananias C. Diokno, editors.
    Epidemiology and Demographics of Underactive Bladder -- Evaluation and Diagnosis of Underactive Bladder.-Urodynamic Evaluation of Underactive Bladder -- Pathophysiology of UAB and Animal Modeling -- Nonsurgical Therapy; Catheters; Devices -- Current Drug Therapy for Underactive Bladder -- Novel Drugs for Underactive Bladder -- Neuromodulation Treatment of Underactive Bladder -- Surgery for Underactive Bladder Treatment -- Advance Technology -- Diabetes and Other Neurogenic Underactive Bladder -- Geriatric Urology and Underactive Bladder -- Pediatrics UAB -- Public Health and Advocacy for Underactive Bladder. Appendix 1: Guide to Underactive Bladder Care -- Appendix 2: Resources to Underactive Bladder Care.-.
  • 2008 Springer
    by Thomas Bonk.
  • 2012
    Charles Henry Brase, Corrinne Pellillo Brase.
    Status: Not Checked OutLane Catalog Record
    1. Getting Started -- 2. Organizing Data -- 3. Averages and Variation -- 4. Elementary Probability Theory -- 5. The Binomial Probability Distribution and Related Topics -- 6. Normal Curves and Sampling Distributions -- 7. Estimation -- 8. Hypothesis Testing -- 9. Correlation and Regression -- 10. Chi-Square and F Distributions -- 11. Nonparametric Statistics.
  • 2016
    the National Center on Addiction and Substance Abuse at Columbia University.
    This white paper reviews and summarizes hundreds of scientific research papers by leading experts in the fields of addiction, eating disorders, obesity and nutrition to lay out the shared characterizing symptoms, risk factors and underlying neurobiological characteristics between food and substance addiction. It describes the differences between food addiction and binge eating disorder (now an official psychiatric diagnosis). It offers evidence-based recommendations for policy, prevention, health care practice and research, and offers informative resources for further examination of this emergent area of work. Finally, it highlights how the knowledge and experience gained from years of research, prevention and intervention work in tobacco, alcohol and other drug control might be applied to controlling another leading threat to the public health: unhealthy eating, overweight and obesity. The National Center on Addiction and Substance Abuse looks forward to contributing to this body of research and policy work through its new program at Yale under the direction of Dr. Carlos Grilo.
  • 2015 Springer
    Magdy El-Salhy, Jan Gunnar Hatlebakk, Trygve Hausken.
    1. Irritable bowel syndrome: what is it? -- 2. The digestive tract and how it works -- 3. The cause of irritable bowel syndrome -- 4. How is irritable bowel syndrome diagnosed? -- 5. Treatment options without medication -- 6. Treatment options involving medication -- 7. There is a light at the end of the tunnel.
  • 2010
    Chad Michael Whitman.
    The mammalian cell surface is comprised of a heterogenous mixture of proteins and lipids decorated by carbohydrates. These molecules are known as glycoconjugates. Among the many types of glycolipids imbedded within the plasma membrane is a class of negatively charged species known as gangliosides. Gangliosides, which are characterized by the presence of sialic acid residues, are responsible for regulating the activity of many cell surface proteins and serve as recognition targets for cell-cell communication and pathogen invasion. To investigate the biological roles of gangliosides in mammalian cells, I have employed metabolic oligosaccharide engineering techniques to introduce small structural changes into sialic acid residues. Using these methods, I have successfully demonstrated the biosynthesis of photocrosslinking gangliosides in mammalian cells. These photocrosslinking gangliosides can be used to capture and isolate transient ganglioside-mediated interactions in their native environment. I have also used metabolic engineering techniques to probe the substrate selectivity of ganglioside sialyltransferases in mammalian cells. My results illustrate significant differences in the ability of different cell lines to metabolize sialic acid analogs; these differences may be due species-specific variations in sialyltransferase specificity.
  • 2012
    Yen Ling Adelene Sim.
    RNA is an important biological macromolecule that carries out a variety of roles in the cell. To function, RNA needs to fold into precise three-dimensional structures. Different physical forces like entropy, base-pairing and stacking interactions, tertiary contacts and electrostatics affect this folding process. In the first part of this thesis, we focus on nucleic acid electrostatics; RNA molecules have negatively charged backbones that require counterions to neutralize charge-repulsion and facilitate folding. We discuss the ion conditions necessary for a riboswitch (gene-regulating RNA found on 5' or 3' ends of messenger RNA) folding, studied how the flexibility of single stranded DNA is affected by the presence of different amounts of counterions and present a benchmark experimental dataset that can be used for direct comparison to electrostatic theories. The second part of the thesis deals with computational and analysis tools developed to model and understand nucleic acid systems with the ultimate goal of being able to predict RNA structure. Since RNA typically folds hierarchically, we devised a general hierarchical sampling protocol that naturally explores RNA three-dimensional conformational space efficiently and can be used in concert with any force field, such as an RNA knowledgebased potential that we also discuss in this thesis. Additionally, we examined a clustering method that can assist analysis of structural models. Lastly, we applied our modeling techniques to study simple two-way RNA junctions with all-atom representation, and probed the modeled effects of sterics, chain connectivity and sequence on dynamic RNA behavior.
  • 2011
    Ariel Veronica Dowling.
    The overall goal of this dissertation is to use novel motion analysis systems to investigate the underlying mechanisms that cause an anterior cruciate ligament (ACL) injury and then to explore movement modification methods that might prevent ACL injuries from occurring. Additionally, novel motion analysis systems can provide new information about ACL injuries and therefore should be used to help analyze these injuries from a different perspective. This thesis provides the results from multiple experimental studies that used two novel motion analysis systems to investigate the underlying causes of ACL injury and potential injury prevention methods. Using a markerless motion capture system, the first investigation determined that increasing the coefficient of friction of the shoe-surface condition will change a subject's movement strategies during a sidestep cutting task in specific ways that may increase the risk of ACL injury. This investigation provides a biomechanical basis for the increased incidence of ACL injuries on high friction surfaces, and suggests that females are more at risk for ACL injury when cutting on high friction surfaces. In terms of novel motion analysis systems, there is a need for simple, cost effective methods to identify athletes at a higher risk for ACL injury during jumping tasks. As such, the second study assessed the capacity of a wearable inertial-based system to evaluate ACL injury risk during jumping tasks. The proposed system measured the knee flexion angle and the trunk lean, and demonstrated good concurrent validity and discriminative performance in terms of the known risk factors for ACL injury. This study also reported the angular velocity of the thigh and shank segments during bilateral and unilateral drop jumps for the first time. Furthermore, this study illustrated that there is an association between the coronal segment angular velocity and knee abduction moment, and that the coronal segment angular velocity can differentiate between subjects at higher risk for ACL injury. Recent studies have shown that the incidence of ACL injury can be decreased through the use of intervention programs. Therefore, the objective for the final study was to determine if an independent inertial-based system can be used to modify jump landing mechanics in order to decrease the risk for ACL injury by providing real-time feedback based on known kinematic and kinetic injury risk factors. This study found that the subjects reduced their risk for ACL injury after training with the system because there were significant increases in the maximum knee flexion angle and the maximum trunk lean. The subjects also reduced their risk for injury by decreasing their thigh coronal angular velocity, which was correlated with a decrease in their knee abduction moment. This study suggests that an inertial-based system could be used for interventional training aimed at reducing the risk for ACL injury.
  • 2006 CRCnetBASE
    edited by Roger Haslam, David Stubbs.
  • 2013 OSO, Limited to 3 simultaneous users
    edited by Sue Ziebland, Angela Coulter, Joseph D. Calabrese, and Louise Locock.
    Improving patient experience is a global priority for health policy-makers and care providers. This book critically examines the various ways in which people's experience of health and healthcare can be recorded, analysed and therefore improved.
  • 2014 WHO
    "Surveillance data collected in vital registration and TB notification systems provide essential information about the TB epidemic and programmatic efforts to control the disease at both national and local levels. Analysis of these data can help programme managers and other staff to track the level of and trends in TB disease burden, detect outbreaks of disease and identify ways to improve existing TB prevention, diagnostic and treatment services. This book provides practical guidance on the analysis and use of such surveillance data, and is suitable for a wide range of people engaged in TB control. It was produced as a major collaborative effort as part of the work of the WHO's Global Task Force on TB Impact Measurement."-- back cover.
    Also available: Print – 2014
  • 2008
    Jerry A. Dorsch, Susan E. Dorsch.
    Status: Not Checked OutLane Catalog Record
    This text once again takes readers step-by-step through all the basic anesthesia equipment. It includes comprehensive references and detailed discussions on the scientific fundamentals of anesthesia equipment, its design, and its optimal use. This thoroughly updated edition includes new information on suction devices, the magnetic resonance imaging environment, temperature monitoring and control, double-lumen tubes, emergency room airway equipment, and many other topics.
  • 2008
    guest editors: John G. Bartlett, Dale N. Gerding.
  • pt. 1-2, 2008
    [edited by] Luca Mainardi, Leif Sörnmo, Sergio Cerutti.
  • 2006 CRCnetBASE
    edited by Steven O. Moldin, John L.R. Rubenstein.
    Integrating basic and clinical neuroscience perspectives, this book presents a comprehensive perspective on state-of-the-art research in epidemiology, genetics, and clinical neuroscience and neural systems implicated in autism. This book seeks to stimulate new directions for autism research on etiology, pathophysiology, and the development of new drug treatment. An underlying theme focuses on the potential for future research given the availability of the human, mouse, and other genomes. The text also explores the role of autism in society, including health economics and advocacy issues of interest to legislators.
  • 2008
    Marketa Zvelebil & Jeremy O. Baum.
  • 2006 Springer
    edited by Sylvie E. Blondelle.
  • 2011
    Melanie Diane Fox.
    Many children with cerebral palsy walk with a stiff knee gait, or a reduction and delay in swing phase knee flexion, which causes tripping or energy-inefficient compensatory movements. Since over-activity of the rectus femoris muscle is frequently implicated as the cause, a common treatment is transfer of the distal end of the rectus femoris from its insertion on the patella to a location behind the knee. Outcomes, though positive on average, vary among individuals, with some patients demonstrating unimproved or worsened knee flexion postoperatively. This variability is due in part to insufficient understanding of the biomechanical causes of stiff-knee gait and the functional effects of surgical treatment. The goal of this dissertation was to clarify the causes of stiff-knee gait and examine the biomechanical mechanism of improvement following rectus femoris transfer surgery. Swing-phase rectus femoris activity is commonly thought to cause of stiff-knee gait, despite evidence that many patients have excessive knee extension moments in preswing rather than swing phase. We compared the effects of preswing to swing phase activity of the rectus femoris on peak knee flexion in swing by creating and analyzing musculoskeletal simulations of subjects with stiff-knee gait. We found that in six out of ten subjects preswing rectus femoris activity had at least a 90% higher effect on peak knee flexion than swing phase rectus femoris activity, suggesting that preswing rectus femoris activity is an important factor limiting knee flexion in some subjects and should be examined to better determine the factors leading to stiff-knee gait. To understand how other muscles, besides rectus femoris, may limit knee flexion in stiff-knee gait, it is first necessary to understand how muscles coordinate successful swing phase knee flexion in unimpaired gait and how muscle contributions change with walking speed, since many stiff-knee subjects walk slowly. We analyzed simulations of unimpaired subjects walking at different speeds to determine the muscles that accelerated and decelerated knee flexion prior to swing. We found that preswing knee flexion acceleration was achieved primarily by the hip flexor muscles with help from biceps femoris short head, suggesting that weakness in these muscles may contribute to stiff-knee gait. Vasti and soleus decelerated knee flexion, suggesting over-activity in these muscles may contribute to stiff-knee gait. We also investigated the mechanism of improvement following rectus femoris transfer surgery. We altered the geometry of rectus femoris and simulated the dynamics of the swing phase of subjects with stiff-knee gait after different surgical procedures. Analysis of the simulations demonstrated that knee flexion may be improved with a reduction of the knee extension moment generated by the rectus femoris, even if the muscle is not converted to a knee flexor. This dissertation clarifies preswing rectus femoris activity as a cause of stiff-knee gait, demonstrates the functional mechanism of improvement following transfer surgery, and informs future research investigating other potential contributors to stiff-knee gait.
  • 2006
    Hippokratis Kiaris.
    Status: Not Checked OutLane Catalog Record
    Some introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue.
  • 2016 Springer
    Ton J. Cleophas, Aeilko H. Zwinderman.
    Randomness -- Randomized and Observational Research -- Randomized Clinical Trials, history, Designs -- Randomized Clinical Trials, Analysis Sets, Statistical Analysis, Reporting Issues -- Discrete Data Analysis, Failure Time Data Analysis -- Quantitative Data Analysis -- Subgroup Analysis -- Interim Analysis -- Multiplicity Analysis -- Medical Statistics : a Discipline at the Interface of Biology and Mathematics.
  • 2014 ebrary
    David Bowers, Allan House, David Owens, Bridgette Bewick.
    Understanding Clinical Papers is a popular and well established introduction to reading clinical papers. It unravels the process of evidence-based practice, using real papers to illustrate how to understand and evaluate published research, and provides clear explanations of important research-related topics.
  • 2013 AccessMedicine
    editors, Renato D. Lopes, Robert A. Harrington.
    Complete how-to guidance on conducting clinical research, this book addresses the operational challenges of clinical trials and provides a clear explanation of the methodologies necessary to interpret results. The book addresses all aspects of clinical trials, from design and implementation to statistics to regulatory scrutiny. A resource for students, residents, and clinicians who need a working knowledge of clinical research principles. The chapter authors are all leaders in the field and engaged in cutting edge clinical research. Use as a textbook, as a reference, and as a course guide for mandated clinical research training courses.
  • 2007 CRCnetBASE
    edited by Lynn Frewer and Hans van Trijp ; sponsored by MATFORSK.
    pt. 1. Key influences on consumer food choice -- pt. 2. Product attributes and consumer food choice -- pt. 3. Diversity in consumer food choice: cultural and individual difference -- pt. 4. Consumers, food and health -- pt. 5. Consumer attitude, food policy and practice.
  • 2014 Karger
    volume editors, O. Hiort, S.F. Ahmed.
    Gonadal development / Lucas-Herald, A.K., Bashamboo, A. -- The masculinization programming window / Welsh, M., Suzuki, H., Yamada, G. -- Androgen action / Werner, R., Holterhus, P.-M. -- Steroid biochemistry / Kamrath, C., Wudy, S.A., Krone, N. -- Next generation sequencing for disorders of sex development / Tobias, E.S., McElreavey, K. -- Advances in neuroimaging / Rodie, M.E., Forbes, K.P., Muir, K. -- Imaging, endoscopy and diagnostic surgery / Wünsch, L., Buchholz, M. -- Fertility issues in the management of patients with disorders of sex development / Guercio, G., Rey, R.A. -- Disorders of sex development peer support / Baratz, A.B., Sharp, M.K., Sandberg, D.E. -- Improving the communication of healthcare professionals with affected children and adolescents / Nordenström, A., Thyen, U. -- Working with adolescents and young adults to support transition / Gleeson, H., Wisniewski, A.B. -- Past experiences of adults with disorders of sex development / GrApSIA, Audí, L. -- Sex hormone replacement in disorders of sex development / Birnbaum, W., Bertelloni, S. -- Hydrocortisone replacement in disorders of sex development / Blankenstein, O. -- Advances in molecular markers of germ cell cancer in patients with disorders of sex development / van der Zwan, Y.H., Cools, M., Looijenga, L.H.J. -- Managing the risk of germ cell tumourigenesis in disorders of sex development patients / Cools, M., Looijenga, L.H.J., Wolffenbuttel, K.P., T'Sjoen, G. -- Timing of hypospadias repair in patients with disorders of sex development / Springer, A., Baskin, L.S. -- Timing of surgery for feminizing genitoplasty in patients suffering from congenital adrenal hyperplasia / Eckoldt-Wolke, F. -- Timing of feminising surgery in disorder of sex development / Wolffenbuttel, K.P., Crouch, N.S. -- Phalloplasty : a panacea for 46,XY disorder of sex development conditions with penile deficiency? / Callens, N.; Hoebeke, P. -- Rare diseases research and practice / Polizzi, A., Balsamo, A., Bal, M.O., Taruscio, D. -- Achieving diagnostic certainty in resource-limited settings / Mazen, I., Raza, J. -- Global application of disorders of sex development-related electronic resources : e-learning, e-consultation and e-information sharing / Muscarella, M., Kranenburg-van Koppen, L., Grijpink-van den Biggelaar, K., Drop, S.L.S. -- International networks for supporting research and clinical care in the field of disorders of sex development / Ahmed, S.F., Bryce, J., Hiort, O.
  • 2007 CRCnetBASE
    Mario Grassi ... [et al.].
    Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes.
  • 2006 ScienceDirect
    edited by S. Anders ... [et al.].
  • 2014 Springer
    Hasan Yazici, Yusuf Yazici, Emmanuel Lesaffre, editors.
    It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics, and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology, and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined, and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, experienced clinicians, and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.
  • 2006 Springer
    Manfred Spitznas ; traducción: Hugo Quiroz-Mercado.
    Also available: Print – 2006
  • 2014 AccessMedicine
    edited by William H. Markle, Melanie A. Fisher, Raymond A. Smego, Jr.
    Global health : past, present and future / Amir A. Khaliq and Raymond A. Smego, Jr. -- The global burden of disease / Thuy D. Bui and William H. Markle -- Epidemiology, biostatistics, and surveillance / Christopher Martin -- The health of women/mothers and children / Judy Lewis, Monika Doshi, Deyanira Gonzalez de Leon, and Amany Refaat -- Human trafficking / Clydette Powell -- Environmental health in the global context / Jeffrey K. Griffiths and Edward Winant -- Nutrition / Clydette Powell and John R. Butterly -- Primary care in global health / Jeffrey F. Markuns and Alain J. Montegut -- Malaria / Paul R. Larson and Mark W. Meyer -- Tuberculosis and HIV/AIDS / Lisa V. Adams and Godfrey B. Woelk -- The neglected tropical diseases / Gregory Juckett -- Emerging diseases and antimicrobial resistance / Arif R. Sarwari and Rashida A. Khakoo -- Injury and global health / Jeffry P. McKinzie -- Surgical issues in global health / Eileen S. Natuzzi, et al. -- Humanitarian assistance and disaster relief / Sheri Fink, Vera Sistenich, and Clydette Powell -- Aging populations and chronic illness / Wayne A. Hale, Jane D. Joubert, and Sebastiana Kalula -- Global mental health : the world mental health surveys perspective / Jordi Alonso, Somnath Chatterji, Yanling He, Philip S. Wang, and Ronald C. Kessler -- Global health communications, social marketing, and emerging communication technologies / Gary Snyder -- Economics and global health / Kevin Chan -- Health systems, management, and organization in global health / David Zakus, Onil Bhattacharyya, and Xiaolin Wei -- Global health ethics / Anvar Velji and John H. Bryant -- Education and careers in global health / Jessica Evert and Scott Loeliger.
  • 2016
    edited by Mara Buchbinder, Michele Rivkin-Fish, and Rebecca L. Walker.
    Health difference, disparity, inequality, or inequity? What difference does it make what we call it? : an approach to conceptualizing and measuring health inequalities and health equity / Paula Braveman -- Global health inequalities and justice / Jennifer Prah Ruger -- Health inequalities and relational egalitarianism / J. Paul Kelleher -- The liberal autonomous subject and the question of health inequalities / Eva Feder Kittay -- Embodied inequalities : an interdisciplinary conversation on oral health disparities / Sarah Horton and Judith C. Barker -- Chasing virtue, enforcing virtue : social justice and conceptions of risk in pregnancy / Debra Debruin, Anne Drapkin Lyerly, Joan Liaschenko, and Mary Faith Marshall -- Justice, respect, and recognition in mental health services : theoretical and testimonial accounts / Paul Brodwin -- Justice, evidence, and interdisciplinary health inequalities research / Nicholas B. King -- Cultural health capital : a sociological intervention into patient-centered care and the Affordable Care Act / Janet K. Shim, Jamie Suki Chang, and Leslie A. Dubbin -- Racial health disparities and questions of evidence : what went wrong with healthy people / Carolyn Moxley Rouse -- Health-care justice, health inequalities, and U.S. health system reform / Carla C. Keirns.
  • 2004 NLM
    United States National Library of Medicine, National Institutes of Health ; prepared by Marcia Zorn, Marin P. Allen, Alice M. Horowitz.
    Examines some of the barriers that may need to be addressed when designing strategies to connect the audience with appropriate health information materials, services, or resources.
  • 2016 AccessMedicine
    Thomas Bodenheimer, Kevin Grumbach.
    Introduction: the paradox of excess and deprivation -- Paying for health care -- Access to health care -- Paying health care providers -- How health care is organized-I: Primary, secondary, and tertiary care -- How health care is organized-II: Health delivery systems -- Health care workforce and the education of health professionals -- Painful versus painless cost control -- Mechanisms for controlling costs -- Quality of health care -- Prevention of illness -- Long-term care -- Medical ethics and rationing of health care -- Health care in four nations -- Health care reform and national health insurance -- Conflict and change in America's health care system -- Conclusion: tensions and challenges -- Questions and discussion topics.
  • 2009
    Thomas S. Bodenheimer, Kevin Grumbach.
    Status: Not Checked OutLane Catalog Record
  • 2012 AccessMedicine
    Thomas Bodenheimer, Kevin Grumbach.
    Introduction: the paradox of excess and deprivation -- Paying for health care -- Access to health care -- Reimbursing health care providers -- How health care is organised--I: primary, secondary, and tertiary care -- How health care is organised--II: health delivery systems -- Health care workforce and the education of health professionals -- Painful versus painless cost control -- Mechanisms for controlling costs -- Quality of health care -- Prevention of illness -- Long-term care -- Medical ethics and rationing of health care -- Health care in four nations -- Health care reform and national health insurance -- Conflict and change in America's health care system -- Conclusion: tensions and challenges -- Questions and discussion topics.
  • 2011
    Ann Gee Lisa Ooi.
    Recent technological advances in high throughput technology, sample preparation and data analysis have made whole genome mRNA and miRNA analysis of purified hematopoietic cell populations much more accessible. The high throughput analysis of the hematopoietic stem cell (HSC) population has yielded massive amounts of data and now we are in the process of biologically validating these targets. Esam1 is one target yielded from microarray analysis of the HSC population. We found Esam1 to be highly and selectively expressed by HSC from mouse bone marrow. Esam1 is also a viable positive HSC marker in fetal, young and aged mice, as well as in mice of several different strains. In addition, we find robust levels of Esam1 transcripts in purified human HSC. Esam1-/- mice do not exhibit severe hematopoietic defects, however, Esam1-/- BM has an increased frequency of HSC and fewer T cells. HSC from Esam1-/- mice give rise to more granulocyte/monocytes in culture and a higher T cell:B cell ratio upon transplantation into congenic mice. These studies identify Esam1 as a novel, widely applicable HSC-selective marker and suggest that Esam1 may play roles in both HSC proliferation and lineage decisions. MicroRNA-125b (miR-125b) is a target yielded from miRNA profiling of the HSC population. We show that miR-125b is highly expressed in HSC and its expression decreases in committed progenitors. Overexpression of miR-125b in mouse HSC enhances their function, demonstrated through serial transplantation of highly purified HSC, and enriches for the previously described Slamf1lo CD34- lymphoid balanced and the Slamf1negCD34- lymphoid biased cell subsets within the multipotent HSC [CD34-KLS] fraction. This enrichment of HSC subsets occur via an anti-apoptotic mechanism, reducing the mRNA expression levels of two pro-apoptotic targets, Bmf and KLF13. The anti-apoptotic effect of miR-125b is more pronounced in the lymphoid biased HSC subset because of their intrinsic higher baseline levels of apoptosis. Together, these data reveal that miR-125b regulates hematopoietic stem cell survival and can promote lymphoid fate decisions at the level of the HSC by preferentially expanding lymphoid balanced and lymphoid biased HSC.
  • 2016 Springer
    Hugh Rayner, Mark Thomas and David Milford.
    1. Kidney anatomy and physiology: the basis of clinical nephrology -- 2. Measuring kidney funciton: quantifying glomerular filtration from laboratory tests -- 4. How are you feeling? The symptoms of uraemia -- 5. Do you have any long-term health conditions? Kidney involvement in multisystem diseases -- 6. Are you pregnant or planning a pregnancy? How pregnancy affects the kidneys and vice versa -- 7. What is your family history? The molecular genetics of inherited kidney diseases -- 8. What have you been taking? Nephrotoxicity from medications and other chemicals -- 9. Height and weight: the effects of kidney disease on body size and composition -- 10. Blood pressure: a common theme in kidney disease -- 11. Test the urine: understanding haematuria, proteinuria and urinary infection -- 13. Full blood count, urea and electrolytes, bicarbonate, bone profile: laboratory results and kidney diseases -- 14. Immunology: serological tests that help diagnose kidney diseases -- 15. Image the urinary tract: strengths and weaknesses of different radiology modalities -- 16. Shoud we do a kidney biopsy? Balancing the diagnostic benefits against the clinical risks -- 17. Make a plan: when and how to prepare for end-stage kidney disease -- 18. Renal replacement therapy: common problems in dialysis and transplant patients -- 19. Epilogue: scaling-up kidney care from one individual to whole population -- Multiple choice questions -- Multiple choice question answers -- Index of case reports -- Index of histopathology, radiology and clinical images -- Index.
  • 2014 Springer
    Brian I. Carr.
    Understanding Liver Cancer is a concise and up-to-date review, which discusses diagnosis, management, patient care, current and emerging therapies, and useful resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of liver cancer as well as a summary of current therapies will benefit from this succinct text.
  • written by Betty Furrie, in conjunction with the Data Base Development Department of the Follet Softward Company ; reviewed and edited by the Network Development and MARC Standards Office, Library of Congress.
  • 2010 Springer
    Ashfaq Hasan.
    Historical Aspects of Mechanical Ventilation / Ashfaq Hasan -- The Indications for Mechanical Ventilation / Ashfaq Hasan -- Physiological Considerations in the Mechanically Ventilated Patient / Ashfaq Hasan -- The Conventional Modes of Mechanical Ventilation / Ashfaq Hasan -- Ventilator Settings / Ashfaq Hasan -- Ventilator Alarms / Ashfaq Hasan -- Monitoring Gas Exchange in the Mechanically Ventilated Patient / Ashfaq Hasan -- Monitoring Lung Mechanics in the Mechanically Ventilated Patient / Ashfaq Hasan -- Mechanical Ventilation in Specific Disorders / Ashfaq Hasan -- The Complications of Mechanical Ventilation / Ashfaq Hasan -- Ventilator-Associated Pneumonia / Ashfaq Hasan -- Discontinuation of Mechanical Ventilation / Ashfaq Hasan -- Noninvasive Ventilation in Acute Respiratory Failure / Ashfaq Hasan -- Negative Pressure Ventilation / Ashfaq Hasan -- Airway Humidification in the Mechanically Ventilated Patient / Ashfaq Hasan -- Aerosol Therapy in the Mechanically Ventilated Patient / Ashfaq Hasan -- Nonconventional Modes and Adjunctive Therapies for Mechanical Ventilation / Ashfaq Hasan -- Case Studies / Ashfaq Hasan.
  • 2008
    Daniel Lee Chao.
    Status: Not Checked OutLane Catalog Record
  • 2014 ebrary
    edited by Tim Swanwick.
    Understanding medical education / Tim Swanwick -- Teaching and learning in medical education: how theory can inform practice / David M Kaufman and Karen V. Mann -- Principles of curriculum design / Janet Grant -- Quality in medical education / Alan Bleakley, Julie Browne and Kate Ellis -- Problem-based learning / Mark A Albanese -- Interprofessional education / Della Freeth -- Work-based learning / Clare Morris and David Blaney -- Supervision, mentoring and coaching / John Launer -- Teaching and leading small groups / Peter McCrorie -- Lectures and large groups / Andrew Long and Bridget Lock -- Technology-enhanced learning / Alison Bullock and Peter de Jong -- E-learning / Scott Rice and Jean McKendree -- Simulation in medical education / Jean Ker and Paul Bradley -- Portfolios in personal and professional development / Erik Driessen and Jan van Tartwijk -- Self-regulated learning in medical education / Casey B. White, Larry D.Gruppen and Joseph C. Fantone -- Learning medicine from the humanities / J. Jill Gordon and H. Martyn Evans -- Patient involvement in medical education / John Spencer and Judy McKimm -- How to design a useful test: the principles of assessment / Lambert WT Schuwirth and Cees PM van der Vleuten -- Written assessment / Brian Jolly -- Workplace assessment / John J Norcini -- Structured assessments of clinical competence / Katharine A. M. Boursicot, Trudie E Roberts and William P Burdick -- Standard setting methods in medical education / Andr F. De Champlain -- Formative assessment / Diana F Wood -- Thinking about research: theoretical perspectives, ethics and scholarship / Jan Illing -- Quantitative research methods in medical education / Geoff Norman and Kevin W Eva -- Qualitative research in medical education: methodologies and methods / Lorelei Lingard, Tara J. Kennedy and Stella Ng -- Programme evaluation: improving practice, influencing policy and decision-making / Chris Lovato and David Wall -- Selection into medical education and training / Fiona Patterson , Eammon Ferguson and Alec Knight -- Career progression and support / Caroline Elton and Nicole J. Borges -- Managing remediation / Deborah Cohen, Melody Rhydderch and Ian Cooper -- Dealing with diversity / Anthony Americano and Dinesh Bhugra -- Developing medical educators: a journey, not a destination / Yvonne Steinart -- Educational leadership / Judy McKimm and Tim Swanwick.
  • 2010 ebrary
    edited by Tim Swanwick.
    Understanding Medical Education originated as a series of monographs in September 2006, the brainchild of Association of Medical Education's then Chief Executive, Frank Smith. The series was designed to meet the needs of all newcomers to medical education. Contributors have included experts from all walks of medical education from across the world. These monographs which have now been collected into a single core textbook, provide a comprehensive guide to the theoretical and academic bases to modern medical education practice--from notes provided by publisher.
  • 2014 AccessMedicine
    Wendy Levinson, Frederic W. Hafferty, Shiphra Ginsburg, Catherine R. Lucey.
    A practical approach to 'professionalism' -- Building professional resiliency -- A brief history of medicine's modern-day professionalism movement -- Professional behaviors and skills needed to deliver patient-centered care -- Integrity and accountability -- Professionalism and a commitment to excellence -- Fair and ethical stewardship of health care resources -- The 'hidden curriculum' and professionalism -- Education -- Evaluating professionalism -- When things go wrong -- Organizational professionalism.
  • 2014 Springer
    Robert M. Bray, Laurel L. Hourani, Jason Williams, Marian E. Lane, Mary Ellen Marsden.
    From the stresses of repeated deployments to the difficulties of re-entry into civilian life, we are just beginning to understand how protracted conflicts, such as those in Iraq and Afghanistan, are affecting service members. Issues such as risky health behaviors and chemical dependence raise productivity concerns as they do with all organizations, but they also have a profound impact on the safety and readiness of troops--and by extension, the military as a whole--in life-or-death situations. Understanding Military Workforce Productivity cuts through the myths and misconceptions about the health and resilience of today's active-duty armed forces. This first-of-its-kind volume presents up-to-date findings across service branches in core health areas including illness and injury, alcohol and drug abuse, tobacco use, obesity, and mental health. The short- and long-term implications discussed relate to the quality of the lives of service members and their families, the quality and preparedness of the military as a workforce, and prevention and intervention efforts.
  • 2007 ProQuest Safari
    Sasha Pachev.
  • 2012 AccessMedicine
    Robert M. Wachter.
    An introduction to patient safety and medical errors -- The nature and frequency of medical errors and adverse events -- Basic principles of patient safety -- Safety, quality, and value -- Medication errors -- Surgical errors -- Diagnostic errors -- Human factors and errors at the person-machine interface -- Transition and handoff errors -- Teamwork and communication errors -- Healthcare-associated infections -- Other complications of healthcare -- Patient safety in the ambulatory setting -- Information technology -- Reporting systems, root cause analysis, and other methods of understanding safety issues -- Creating a culture of safety -- Workforce issues -- Education and training issues -- The malpractice system -- Accountability -- Accreditation and regulations -- The role of patients -- Organizing a safety program.
  • 2016 Springer
    Philippe Courtet, editor.
    In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention. Understanding Suicide will be of interest to psychiatrists, psychologists, mental health professionals, general practitioners, researchers in suicidology, and students.
  • 2014 AccessMedicine
    Gordon Mosser, James W. Begun.
    A complete introductory guide to the principles and clinical application of team-based medicine, Understanding Team-Based Healthcare emphasizes the essential competencies necessary to implement team-based medicine in a complex hospital or primary care setting. Unlike similar books on the subject which are theoretical or policy-oriented, this text offers practical, real-world coverage, and is valuable for healthcare professionals seeking a thorough explanation of teamwork and for trainers working in hospitals or primary care settings. Features: could also be used as a textbook; mini-cases throughout the text help readers appreciate real-world application of principles; written for a level suited for the non-specialist.
  • 2010
    Sean Frederick Scanlan.
    The overall goal of this dissertation was to address the question of the relationship between anterior cruciate ligament (ACL) graft function, changes in walking mechanics, and the morphology of the articular cartilage in the ACL reconstructed knee as a step towards filling critical gaps in the available knowledge of the association between ACL injury and premature osteoarthritis of the knee. ACL injury often leads to premature osteoarthritis of the knee even when the ACL is reconstructed and alterations in knee mechanics during walking have been identified as a potential mechanism of cartilage degeneration in the ACL deficient knee. This thesis provides the results of experimental studies using magnetic resonance (MR) imaging and gait analysis to understand the effect of ACL reconstruction on the mechanics of walking and articular cartilage morphology in the context of a potential mechanism for the initiation of osteoarthritis. These results provide a basis for improving the treatment and long-term prognosis of the ACL injured knee. Gait analysis of subjects after ACL reconstruction showed that during the stance phase of walking, their ACL reconstructed knee had significantly more external tibial rotation when compared to their contralateral knee. This kinematic alteration likely causes changes in normal cartilage contact mechanics and could contribute to the eventual degeneration of the articular cartilage. Analysis of ACL graft placement in this population revealed a potential mechanism for the observed alteration in ambulatory mechanics in the ACL reconstructed knee. Variations in graft placement were correlated with the magnitude of the peak external knee flexion moment (balanced by a net quadriceps moment) and the tibiofemoral rotational position of the reconstructed knee during walking. In both cases, non-anatomic graft placement resulted in greater deviations in the ambulatory mechanics of the ACL reconstructed knee. Since these results indicated graft placement plays a critical role in the restoration of normal ambulatory mechanics, MR imaging was utilized to develop a method to determine the three-dimensional location of native tibial and femoral ACL insertions to guide and evaluate anatomic ACL graft placement. Analysis of healthy and ACL reconstructed subjects revealed the presence of side-to-side symmetry in location of ACL insertions in healthy subjects but not after transtibial ACL reconstruction, indicating that conventional transtibial reconstruction frequently places the graft outside the center of the anatomical ACL footprint. Further examination of the effects of non-anatomic ACL graft placement revealed the unintended consequences of vertical sagittal orientation of the ACL graft. These results demonstrated that although vertical sagittal graft orientation was associated with less occurrence of an active knee extension deficit during walking (as intended), it was also associated with an increased anterior tibial neutral position in the ACL reconstructed knees. Finally, in order to investigate the mechanism of the proposed kinematic pathway to osteoarthritis after ACL reconstruction, the individual-specific femoral cartilage thickness distribution was related to knee flexion during walking in the reconstructed and healthy contralateral knees. The results of this study showed that although a relationship existed in both the reconstructed and contralateral knees, a shift in knee flexion at heel-strike without an adaptation in cartilage thickness distribution caused an alteration in the relationship in the ACL reconstructed knees. Thus failure of the ACL reconstruction to restore normal walking mechanics could contribute the breakdown of articular cartilage in the ACL reconstructed knee. The results of these studies provide a better understanding of the influence of ACL reconstruction on the subsequent changes in the mechanics of the ACL reconstructed knee. These findings present insights into the complex relationship between variations in ACL graft placement, changes in walking mechanics, and the distribution of cartilage thickness in the context of a potential kinematic mechanism for the development of premature osteoarthritis after ACL injury and reconstruction. Taken together, these results provide a basis for improving the standard of care for the ACL injured knee.
  • 2012
    Jia-Ren Lin.
    Post-replication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18-mediated translesion synthesis (TLS) are two forms of PRR. Two Rad5-related proteins, SHPRH and HLTF, have been identified in mammalian cells, but their specific roles in PRR are unclear. Here, we show that HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV and MMS, respectively. Following UV, HLTF enhances PCNA monoubiquitination and recruitment of TLS polymerase eta, while also inhibiting SHPRH function. In contrast, MMS promotes the degradation of HLTF and the interactions of SHPRH with Rad18 and polymerase kappa. Our data not only suggest that cells differentially utilize HLTF and SHPRH for different forms of DNA damage, but also, surprisingly, that HLTF and SHPRH may coordinate the two main branches of PRR to choose the proper bypass mechanism for minimizing mutagenesis. Though the degradation of HLTF is required for the SHPRH-Rad18 interaction in MMS-damaged cells, knockdown of HLTF is not sufficient to induce SHPRH-Rad18 binding in undamaged cells. Thus, an unidentified factor, in addition to HLTF degradation, is required to fully activate SHPRH and Rad18 upon MMS damage. We have noticed that Rad18 is deubiquitinated after MMS treatment, and that this de-ubiquitination is correlated with the degree of Rad18-SHPRH interaction. Moreover, we show that promoting the ubiquitination of Rad18 has an inverse effect on the interaction with SHPRH both in vitro and in cells. Surprisingly, though, the ubiquitinated Rad18 shows a stronger self-interaction than the wild-type Rad18, opposite from the SHPRH binding results. As the zinc-finger motif of Rad18 has been previously shown to bind ubiquitin, this may be a logical mechanism to control the switch between Rad18 dimerization and its interaction with other proteins. Interestingly, ubiquitinated Rad18 appears to be inactive, not only from loss of its ability to interact with SHPRH, but also through the inability to form damage foci and suppress MMS-induced mutagenesis. Altogether, our data reveal a unique regulation of Rad18 through self-ubiquitination and dimerization. In summary, our studies have revealed a number of new mechanistic insights into the post-replication repair pathways in human cells, including the interesting conclusion that protein degradation, deubiquitination, and other key cell processes may be controlled in a DNA damage-specific manner.
  • 2013
    Ruth Sommese.
    Heart disease is one of the leading causes of morbidity and mortality in the developed world. As such, significant amount of resources and energy are funneled into developing treatments and therapeutics. While genetically caused cardiovascular diseases manifest at the tissue level, the fundamental mechanism that triggers the secondary effects and tissue remodeling generally occurs at the protein level. It is therefore critical to understand the molecular changes on the basic biochemical and biophysical level and connect these to the cellular and developmental disease processes. One such cardiovascular disorder is hypertrophic cardiomyopathy or HCM, which has been estimated to affect approximately 1 in 500 individuals. It disproportionately affects young adults and is the leading cause of sudden cardiac death. Since the first case of genetically linked HCM was identified in the early 1990s, a significant amount of work has been done to understand the molecular mechanism of the disease. Mutations have been identified in the proteins comprising the contractile apparatus of the muscle, the sarcomere. One such protein is [beta]-cardiac myosin, which has been recognized as a significant culprit of genetically linked HCM (~30-50%). Many studies have been performed to understand how single point mutations can alter the enzymatic and mechanical properties of this motor protein, but there is no clear consensus about the molecular mechanism. This has been due mainly to the lack of available human [beta]-cardiac myosin and the use of non-human and non-[beta]-cardiac myosin. Non-human and non-[beta]-cardiac myosin from common animal models differ by >30 residues, and as clearly evident from the disease and from previous studies on myosin, a single amino acids mutation can significantly alter and disrupt myosin function. During my thesis work, I have performed the first biochemical and biophysical work in the field looking at cardiomyopathy mutations using human [beta]-cardiac myosin. I have shown that HCM-causing [beta]-cardiac myosin mutations result in a gain of function, increasing the power or work output of the myosin. I have also examined HCM-causing mutations in troponin T, a component of the thin filament regulatory unit, using human [beta]-cardiac myosin. In the muscle, the interaction of myosin and actin is regulated by calcium through the thin filament proteins, namely the troponin complex and tropomyosin. HCM-causing mutations in troponin T increase calcium sensitivity or the number of force-producing heads that can interact with actin, thereby also increasing force or power output in the muscle. My work not only sheds light on fundamental properties of thick and thin filament function in the human sarcomere and presents the first studies of HCM-causing mutants in a human background, it also establishes a new approach to the problem of cardiomyopathy that will be critical in truly understanding and targeting the disease.
  • 2011
    Danielle Lurisa Leiske.
    The tear film is the thin layer of fluid that covers the surface of the eye. While the functions of the tear film are numerous, the primary role is to protect the corneal surface. When an individual has dry eye disease the tear film breaks up and exposes the corneal epithelial cells, which leads to ocular irritation. The primary components of the outermost layer of the tear film are meibomian lipids, a mixture of long chain nonpolar lipids. Although this lipid layer is thought to play an important role in tear film stability, little is known about the structure and viscoelasticity of meibum, or how these properties relate to tear film stability in dry eye disease. The primary focus of this work was to understand how meibum behaves at an air-water interface to mimic the in vivo conditions of the tear film lipid layer. At room temperature meibum was found to form a predominantly elastic interfacial film, although the film became more fluid as it was heated to body temperature. Interfacial x-ray scattering at room temperature revealed ordered lattices and multilayers at high levels of compression that contributed to high elasticity. In bulk samples, small angle x-ray scattering identified two populations of lipid lamellar phases with unique melt behavior. Meibum collected from patients with meibomian gland dysfunction, a form of dry eye disease, contained the same crystalline phases; however, the prevalence of those phases was reduced indicating a quantifiable change in lipid composition. To ascertain whether meibum viscoelastic properties are relevant to tear film performance, the effects of surface elasticity on an advancing droplet were studied. While droplets covered with a Newtonian monolayer followed classical hydrodynamics, meibum and other insoluble surfactants with surface shear elasticity induced periodic stick-release of the contact line at low advancing velocities and non-ideal behavior at higher velocities. Finally, to explore how a water soluble surfactant may be used to repair a compromised lipid layer, the interactions between a poly(ethylene oxide)-poly(butylene oxide) block copolymer (EOBO) and a model phospholipid monolayer were studied. The lipids and EOBO remained phase separated at the interface, yet EOBO was able to restore the native lattice spacing and mechanical properties of the lipid monolayer, which could make it a valuable tool for a number of biological applications. Meibomian lipids are a complex natural extract with a number of remarkable properties. Although the lipids present in meibum are diverse, meibum can form an elastic interfacial film with ordered phases in bulk material or at an interface. We have shown a link between meibum structure and elasticity, which both depend on temperature. Major composition changes that occur with disease could alter meibum melt temperature and viscoelasticity, which will ultimately modulate the ability of meibum to stabilize the tear film.
  • 2009
    Deborah Lynn Burkhart.
    Status: Not Checked OutLane Catalog Record
  • 2015 AccessMedicine
    editors, Christopher Moriates, Vineet Arora, Neel Shah.
    The current state of healthcare costs and waste in the United States -- Medical coverage in the United States -- The challenges of understanding healthcare pricing -- Defining value : connecting quality and safety to the costs of care -- A changing landscape : cost consciousness and value in healthcare delivery -- Ethics of cost conscious care -- The importance of zip codes and genetic codes : variation in resource utilization -- Stents, robots, and the role of technology diffusion -- Primary care shortage crisis : lost opportunities to deliver value / David Margolius and Andrew Morris-Singer -- Barriers to providing high-value care / Daisy Smith and Steven Weinberger -- Building a pipeline for change : teaching about cost awareness and evidence-based medicine -- The role of patients : shared decision making, e-patients, and consumer directed healthcare -- High-value medication prescribing -- Screening and prevention : balancing benefits with harms and costs -- Shifting incentives : moving reimbursement from volume to value -- Implementing value-based initiatives : a new challenge for clinicians and healthcare systems.
  • 2006
    Raymond H. Colton, Janina Casper, Rebecca Leonard ; with contributions from Susan Thibeault, Richard Kelley ; selected color photographs by Eijii Yanagisawa.
    Status: Not Checked OutLane Catalog Record
    Differential diagnosis of voice problems -- Morphology of vocal fold mucosa : histology to genomics -- Phonotrauma : its effects on phonatory physiology -- Voice problems associated with nervous system involvement -- Voice problems associated with organic disease, and trauma -- Voice problems associated with the pediatric and the geriatric voice -- The voice history, examination and testing -- Surgical and medical management of voice disorders -- Voice rehabilitation -- Anatomy of the vocal fold mechanism -- Phonatory physiology -- Neuroanatomy of the vocal mechanism -- Some normative data on the voice.
  • 2013 ClinicalKey
    edited by Simon S. Cross ; illustrations and chapter icons by Robert Britton.
    What is pathology? -- What is disease? -- What causes disease? -- Disorders of growth, differentiation and morphogenesis -- Responses to cellular injury -- Disorders of metabolism and homeostasis -- Ischaemia, infarction and shock -- Immunology and immunopathology -- Inflammation -- Carcinogenesis and neoplasia -- Ageing and death -- How do pathologists help patient care? -- Cardiovascular system -- Respiratory tract -- Liver, biliary system and pancreas -- Endocrine system -- Breast -- Female genital tract -- Urinary and male genital tracts -- Kidney diseases -- Lymph nodes and extranodal lymphoid tissue, spleen and thymus -- Blood and bone marrow -- Skin -- Osteoarticular and connective tissues -- Central and peripheral nervous systems.
  • 2012 CRCnetBASE
    Yair Altman.
    "Preface The Matlab programming environment uses Java for numerous tasks, including networking, data-processing algorithms, and graphical user-interface (GUI). Matlab's internal Java classes can often be easily accessed and used by Matlab users. Matlab also enables easy access to external Java functionality, either third-party or user-created. Using Java, we can extensively customize the Matlab environment and application GUI, enabling the creation of very esthetically pleasing applications. Unlike Matlab's interface with other programming languages, the internal Java classes and the Matlab-Java interface were never fully documented by The MathWorks (TMW), the company that manufactures the Matlab product. This is really quite unfortunate: Java is one of the most widely used programming languages, having many times as many programmers as Matlab. Using this huge pool of knowledge and components can significantly improve Matlab applications. As a consultant, I often hear clients claim that Matlab is a fine programming platform for prototyping, but is not suitable for real-world modern-looking applications. This book aimed at correcting this misconception. It shows how using Java can significantly improve Matlab program appearance and functionality and that this can be done easily and even without any prior Java knowledge. In fact, many basic programming requirements cannot be achieved (or are difficult) in pure Matlab, but are very easy in Java. As a simple example, maximizing and minimizing windows is not possible in pure Matlab, but is a trivial one-liner using the underlying Java codeʹ:"--Provided by publisher.
  • 2015 Springer
    Glenn L. Schattman, Sandro C. Esteves, Ashok Agarwal, editors.
    Part I: Definitions and Epidemiology -- Definitions and Relevance of Unexplained Infertility in Reproductive Medicine -- Definitions and Epidemiology of Unexplained Male Infertility -- Controversies Surrounding the 2010 World Health Organization Cutoff Values for Human Semen Characteristics and Its Impact on Unexplained Infertility -- Definitions and Epidemiology of Unexplained Female Infertility -- Part II: Pathophysiology: Male -- Sperm Biology from Production to Ejaculation -- Idiopathic Infertility: Survival and Function of Sperm in the Female Reproductive Tract -- Potential Male Etiologies of Unexplained Infertility -- Genetic Basis of Unexplained Male Infertility -- Role of the Immune System in Unexplained Male Infertility -- Oxidative Stress in Unexplained Male Infertility -- Role and Significance of Sperm Function in Men with Unexplained Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility -- Part III: Pathophysiology: Female -- Potential Female Etiologies of Unexplained Infertility -- Oxidative Stress in Unexplained Female Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Female Infertility -- Cervical Hostility and Vaginal pH in Females with Unexplained Infertility -- Role of Endometrial Receptivity in Unexplained Infertility -- Fallopian Tube Dysfunction in Unexplained Infertility -- Subtle Endometriosis and Unexplained Infertility -- Part IV: Evaluation -- Evaluation of Women with Unexplained Infertility -- Evaluation of Men with Unexplained Infertility -- Part V: Expectant, Medical and Surgical Treatment -- The Role of Expectant Management for Couples with Unexplained Infertility -- Treatment and Prognosis of Immunological Factors in Unexplained Male Infertility -- Medication Strategies for the Male with Unexplained Infertility -- Clomiphene Citrate for Women with Unexplained Infertility -- Aromatase Inhibitors in the Treatment of Unexplained Female Infertility -- Gonadotropins for Women with Unexplained Infertility -- Part VI: Assisted Reproductive Techniques and Future Perspectives -- Gonadotropin in Assisted Reproduction: An Evolution Perspective -- Intrauterine Insemination in Unexplained Female Infertility -- Role of In Vitro Fertilization in Unexplained Female Infertility -- Role of Assisted Reproduction Techniques in the Management of Unexplained Male Infertility -- Future Perspectives in the Diagnosis and Management of Unexplained Male Infertility.
  • pt. A-C, 2011. ScienceDirect
    pt. B ScienceDirect
    pt. C ScienceDirect
    edited by P. Michael Conn.
    Also available: Print – pt. A-C, 2011.
  • 2015 Springer
    edited by Michael T. Hirschmann, Roland Becker.
    Owing to improved understanding of biomechanics and tribology and advances in implant design and treatment technique, total knee arthroplasty (TKA) is considered a very successful treatment for osteoarthritic knees. Nevertheless, a significant minority of patients are unhappy with the outcome, complaining of pain, instability, swelling, or reduced range of motion. This book addresses the need for improved diagnostic and treatment guidelines for this challenging group of patients. The book opens by discussing the basics of TKA and the various causes of failure and pain. Diagnostic aspects are considered in detail, with attention to advances in clinical investigation, laboratory analysis, and, in particular, imaging techniques. Furthermore, state of the art diagnostic algorithms are presented that will assist in identifying the source of the problem in individual cases. Specific pathology-related treatment options, including conservative approaches and salvage and revision TKA strategies, are then explained, with identification of the pitfalls and key points of each treatment. Future perspectives are briefly considered, and a series of cases are presented that cover clinical scenarios frequently encountered in daily clinical practice. The evidence-based, clinically focused guidance provided in this book, written by internationally renowned experts, will assist surgeons in ensuring that patients with an unsatisfactory result of TKA receive the most effective management. The book will also be helpful for general practitioners, physiotherapists, industry technicians, and engineers.
  • 2005 ProQuest Safari
    James Rumbaugh, Ivar Jacobson, Grady Booch.
  • 2004
    Covers guidelines for the format of manuscripts submitted to biomedical journals. In addition, discusses retraction of research findings, order of authorship, definition of a peer-reviewed journal, and conflict of interest. Each statement was initially published in a scientific journal and citations to the original publications are included.
    Also available: Print – 1994-
  • 2006
    Tracy Lyn Staton.
    Status: Not Checked OutLane Catalog Record
  • CDC/NCI
    Also available: Print – 2002
  • 2008 Springer
    edited by Shahid Rahman, Tony Street, Hassan Tahiri.
  • Wendy Chisholm and Matt May.
  • 1990-2006. (including updates)
    managing editor, Linda L. Cherner.
    Status: Not Checked OutLane Catalog Record
  • 2006 Springer
    edited by Mordechai Feingold and Victor Navarro-Brotons.
    "Mathematics for astronomy" at universities in Copernicus' time / Grazina Rosińska -- The University of Salamanca and the renaissance of astronomy during the second half of the 15th century / José Chabás -- Medical science and medical teachings at the University of Salamanca in the 15th century / Luis García Ballester -- The faculty of medicine of Valencia / José M. López Piñero -- The cultivation of astronomy in Spanish universities in the latter half of the 16th century / Victor Navarro-Brotons -- The Sphere of Jacques du Chevreul: astronomy at the University of Paris in the 1620s / Roger Ariew -- Lectures and practices: the variety of mathematical and mechanical teaching at the University of Uppsala in the 17th century / Maija Kallinen -- Mathematical research in Italian universities in the modern era / Maria Teresa Borgato -- Universities, academies, and sciences in the modern age / Luigi Pepe -- Natural philosophy and mathematics in Portuguese universities, 1550-1650 / Luís Miguel Carolino & Henrique Leitão -- Venetian policy toward the University of Padua and scientific progress during the 18th century / Piero del Negro -- Candide in Caledonia: the culture of science in the Scottish universities, 1690-1805 / Paul Wood -- The sciences at the University of Rome in the 18th century / Ugo Baldini -- Enlightenment and renovation in the Spanish university / José Luis Peset -- Spanish chemistry textbooks during late 18th century / Antonio García Belmar and José Ramón Bertomeu Sánchez -- Botany in University studies in the late 18th century : the case of Valencia University / Cristina Sendra-Mocholí -- Scientific education and the crisis of the university in 18th century Barcelona / Agustí Nieto-Galan & Antoni Roca-Rosell -- The theories of Copernicus and Newton in the Viceroyship of Nueva Granada and the Audiencia de Caracas during the 18th century / Luis Carlos Arboleda Aparicio & Diana Soto Arango.
  • 2008 Springer
    by Hanns Hippius, Hans-Jürgen Möller, Norbet Müller, Gabriele Neundörfer-Kohl.
    Early Psychiatric Institutions in Munich -- Psychiatric Care in Bavaria in the 19th Century -- The Chair for Psychiatry at the Medical Faculty of the University of Munich -- Bernhard von Gudden, Doctor and Founder of Modern Neuromorphology -- Planning and Construction of the Royal Psychiatric University Hospital in the Nussbaumstrasse -- The Opening of the Psychiatric Hospital in 1904 by Emil Kraepelin -- The Munich Hospital Managed by Emil Kraepelin -- The Idea and Planning of the German Psychiatric Research Institute -- Oswald Bumke and his Munich Workgroup -- The Post War Period and Beginning of the Hospital's Reconstruction under Georg Stertz -- Kurt Kolle and Plans for a New Hospital Building in Grosshadern -- Division of the "Hospital for Nervous Diseases" into a Psychiatric Hospital in the Inner City and a Neurological Hospital in Grosshadern -- The Psychiatric Hospital since 1994 -- The Psychiatric Hospital 1971-1994 -- The Re-Opening of the Historical Old Building -- Scientific publications since 2000.
  • 2008 Springer
    by Hanns Hippius ... [et al.].
  • 2006 ProQuest Safari
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    Arnold Robbins.
    Introduction -- Unix commands -- The Unix shell: an overview -- The Bash and Korn shells -- tcsh: an extended C shell -- Package management -- Pattern matching -- The Emacs editor -- The vi, ex, and vim editors -- The sed editor -- The awk programming language -- Source code management: an overview -- The revision control system -- The concurrent versions system -- The subversion version control system -- The GNU make utility -- The GDB debugger -- Writing manual pages.
  • 2013
    Paola Bergallo.
    Demands for the protection of social rights, and health rights in particular, have become a distinctive feature of judicialization in Latin American countries, including Argentina. Although a growing number of studies have begun to document the new relationship between the courts and health rights generated after almost two decades of litigation, little is yet empirically known about the versatile struggles undertaken in domestic courts and their consequences beyond the judgments. More specifically, given the scarcity of domestic empirical explorations, much remains to be discovered about legal mobilization experiences and courts' roles in the adjudication of conflicts regarding the intersection of health policies and rights. This dissertation takes a step toward filling that gap by exploring a set of conceptual, theoretical, and methodological questions that are critical to advancing current debates on health and the role of courts in bringing justice and expanding the rule of law in Argentina. With that aim in mind, this dissertation proceeds in two stages. First, it offers a basic assessment of the context and magnitude of the judicialization of health in the country, relying on multiple secondary sources and descriptive statistics obtained from databases of court decisions and dockets generated for this dissertation. Second, to complement the broader picture, the project proposes a qualitative study of strands of health rights litigation, offering a process-based observation of diverse patterns of judicialization while helping identify and compare the broader impacts of courts' roles in adjudicating health rights demands. Through these narrative studies, this dissertation tells the story of how once-dormant health rights clauses have come to life through the work of litigants, judges, and policy makers. It also shows how, in the process of unleashing health rights, courts have played contradictory roles throughout the nonlinear trajectories of different patterns of judicialization that can be located along a spectrum in which an atomistic and routinized style of judicialization is at one extreme, a bureaucratizing form of judicialization is in the middle, and a cooperative style of judicialization is at the other extreme. Ultimately, throughout these rich and variegated experiences of judicialization, courts' adjudication of right-to-health claims has sometimes reinforced ineffective or unequal arrangements, while at other times exhibiting potentially transformative capacities.
  • 2015
    J. David Hawkins, Jeffrey M. Jenson, Richard Catalano, Mark W. Fraser, Gilbert J. Botvin, Valerie Shapiro, C. Hendricks Brown, William Beardslee, David Brent, Laurel K. Leslie, Mary Jane Rotheram-Borus, Pat Shea, Andy Shih, Elizabeth Anthony, Kevin P. Haggerty, Kimberly Bender, Deborah Gorman-Smith, Erin Casey, and Susan Stone.
    Every day across America, behavioral health problems in childhood and adolescence, from anxiety to violence, take a heavy toll on millions of lives. For decades the approach to these problems has been to treat them only after they've been identified--at a high and ongoing cost to young people, families, entire communities, and our nation. Now we have a 30-year body of research and more than 50 programs showing that behavioral health problems can be prevented. This critical mass of prevention science is converging with growing interest in prevention across health care, education, child psychiatry, child welfare, and juvenile justice. Together, we stand at the threshold of a new age of prevention. The challenge now is to mobilize across disciplines and communities to unleash the power of prevention on a nationwide scale. Proposes a grand challenge that will advance the policies, programs, funding, and workforce preparation needed to promote behavioral health and prevent behavioral health problems among all young people--including those at greatest disadvantage or risk, from birth through age 24. Within a decade, we can reduce the incidence and prevalence of behavioral health problems in this population by 20 percent from current levels through widespread policies and programs that will serve millions and save billions. Prevention is the best investment we can make, and the time to make it is now.
  • 2014
    Georg Northoff.
    V. 1. Coding -- v. 2. Consciousness.
  • 2012 Springer Protocols
    edited by Loredano Pollegioni, Stefano Servi.
    Preparation of unnatural amino acids with ammonia-lyases and 2,3-aminomutases / László Poppe [and others] -- Multistep enzyme catalyzed reactions for unnatural amino acids / Paola D'Arrigo and Davide Tessaro -- Enzymatic production of enantiopure amino acids from mono-substituted hydantoin substrates / Gwynneth F. Matcher, Rosemary A. Dorrington, and Stephanie G. Burton -- Preparation of glutamate analogues by enzymatic transamination / Thierry Gefflaut, Zeinab Assaf, and Martine Sancelme -- Carbon-carbon bond-formng enzymes for the synthesis of non-natural amino acids / Pere Clapés, Jesús Joglar, and Mariana Gutiérrez -- Engineering cyclic amidases for non-natural amino acid synthesis / Francisco Javier Las Heras-Vázquez [and others] -- NMR analysis of unnatural amino acids in natural antibiotics / Franca Castiglione -- Site-specific incorporation of unnatural amino acids as probes for protein conformational changes / Jennifer C. Peeler and Ryan A. Mehl -- Application of unnatural amino acids to the de novo design of selective antibiotic peptides / Rickey P. Hicks and Amanda L. Russell -- Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides / Alessandro Tossi [and others] -- Experimental methods for scanning unnatural amino acid mutagenesis / Jia Liu and T. Ashton Cropp -- Genetic incorporation of unnatural amino acids into proteins in yeast / Qian Wang and Lei Wang -- Site-specific incorporation of unnatural amino acids into proteins in mammalian cells / Nobumasa Hino, Kensaku Sakamoto, and Shigeyuki Yokoyama -- Incorporation of unnatural non-[alpha]-amino acids into the N-terminus of proteins in a cell-free translation system / Takahiro Hohsaka -- Site-specific modification of proteins by the Staudinger-phosphite reaction / Paul Majkut [and others] -- HPLC methods for determination of D-aspartate and N-methyl-D-aspartate / George H. Fisher and Mara Tsesarskaia -- Estimation of chronological age from the racemization rate of L- and D-aspartic acid : how to completely separate enantiomers from dentin / Toshiharu Yamamoto and Susumu Ohtani -- Enzymatic detection of D-amino acids / Gianluca Molla [and others] -- An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures / Inna Radzishevsky and Herman Wolosker -- Electrophysiological analysis of the modulation of NMDA-receptors function by D-serine and glycine in the central nervous system / Fabrice Turpin, Glenn Dallérac, and Jean-Pierre Mothet -- Biosensors for D-amino acid detection / Silvia Sacchi [and others] -- Analysis of D-[beta]-aspartyl isomers at specific sites in proteins / Noriko Fujii and Horihiko Fujii -- Nutritional value of D-amino acids, D-peptides, and amino acid derivatives in mice / Mendel Friedman and Carol E. Levin -- Preparation and assay of recombinant serine racemase / Florian Baumgart, Clara Aicart-Ramos, and Ignacio Rodriguez-Crespo -- Assay of amino acid racemases / Masumi Katane, Masae Sekine, and Hiroshi Homma -- Assays of D-amino acid oxidases / Gabriella Tedeschi, Loredano Pollegioni, and Armando Negri -- Enzymes acting on D-amino acid containing peptides / Yasuhisa Asano.
  • 2013
    Philip Lieberman.
    "The Unpredictable Species argues that the human brain evolved in a way that enhances our cognitive flexibility and capacity for innovation and imitation. In doing so, the book challenges the central claim of evolutionary psychology that we are locked into predictable patterns of behavior that were fixed by genes, and refutes the claim that language is innate. Philip Lieberman builds his case with evidence from neuroscience, genetics, and physical anthropology, showing how our basal ganglia--structures deep within the brain whose origins predate the dinosaurs--came to play a key role in human creativity. He demonstrates how the transfer of information in these structures was enhanced by genetic mutation and evolution, giving rise to supercharged neural circuits linking activity in different parts of the brain. Human invention, expressed in different epochs and locales in the form of stone tools, digital computers, new art forms, complex civilizations--even the latest fashions--stems from these supercharged circuits." -- [Publisher-supplied data]
  • 2013
    Alexis Jane Battle.
    Recent technological advances have allowed us to collect genomic data on an unprecedented scale, with the promise of revealing genetic variants, genes, and pathways disrupted in clinically relevant human traits. However, identifying functional variants and ultimately unraveling the genetics of complex disease from such data have presented significant challenges. With millions of genetic factors to consider, spurious associations and lack of statistical power are major hurdles. Further, we cannot easily assess functional roles even for known trait-associated variants, particularly for those that lie outside of protein-coding regions of the genome. To address these challenges in identifying the genetic factors underlying complex traits, we have developed probabilistic machine learning methods that leverage biological structure and prior knowledge. In this thesis, we describe four applications of such models. First, we present a method for reconstructing causal gene networks from interventional genetic interaction data in model organisms. Here, we are able to identify intricate functional dependencies among hundreds of genes affecting a complex trait. We have applied this method to understanding the genetics of protein folding in yeast, where we demonstrate ability to recapitulate the details, including ordering, of known pathways, and make novel functional predictions. Second, we present PriorNet, a method for incorporating gene network and path- way information into the analysis of population-level studies of genetic variation in human disease. PriorNet utilizes a flexible, Markov Random Field prior to propagate information between functionally related genes and related diseases, in order to improve statistical power in large-scale disease studies. We demonstrate a significant improvement in the discovery of disease-relevant genes in studies of three autoimmune diseases. Next, we extend the intuitions of PriorNet in a method for identifying interactions between genetic variants in human disease, to begin to understand how genes work together in complex disease processes. Our method, GAIT, leverages gene networks, network structure, and other patterns to adaptively prioritize candidate in- teractions for testing, and dramatically reduce the burden of multiple hypothesis correction to identify a large number of interactions in diverse human disease studies. Finally, we discuss the identification of functional variants on a large scale through the use of gene expression as a high-resolution cellular phenotype. We have sequenced RNA from 922 genotyped individuals to provide a direct window into the distribution, properties, and consequences of thousands of regulatory variants affecting diverse gene expression traits including splicing and allelic expression. From the identified variants, we also train a model, LRVM, for predicting regulatory consequences based on location and genomic properties of each variant.
  • 2006
    Takaki Komiyama.
    Status: Not Checked OutLane Catalog Record
  • 2014
    Shafiqul Alam Kiron ; concept and text, Monira Rahman [and three others].
  • 2013 Springer
    Lucy W. Barrett, Sue Fletcher, Steve D. Wilton.
    There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns.
  • 2011 Springer
    O.S. Miettinen.
    Pt. 1. Philosophical propedeutics -- pt. 2. Theory of clinical medicine -- pt. 3. Theory of clinical research -- pt. 4. Contemporary realities in clinical research -- pt. 5. Epilogue on major improvements in clinical medicine -- pt. 6. Appendices.
  • 2013 Springer
    Antonella Tosti, Doris Hexsel, editors.
    This well-illustrated guide provides concise descriptions of the most frequently encountered cosmetic skin conditions and essential information on commonly employed treatment procedures. The book opens with a description of skin evaluation systems and then documents etiology, pathogenesis, diagnosis, and treatment for various conditions, including cellulite, acne, hirsutism, and striae distensae. The second part of the book provides step-by-step guidelines on a range of cosmetic procedures, such as botulinum toxin injection, cryosurgery, electrosurgery, and injection lipolysis. The advice provided will be invaluable for all physicians who intend to incorporate these procedures into their practices. The book will also be of interest to established specialists in cosmetic dermatology wishing to update their knowledge and to all general dermatologists and plastic surgeons required to answer the numerous questions posed by patients seeking to maintain or improve the quality of their skin.
  • 2006 HighWire
    edited by Jean-Pierre Bassand.
  • 2008
    guest editors: Marin H. Kollef ...
  • 2005 Springer
    edited by David C. Chhieng and Gene P. Siegal.
    Surgical pathology of the parathyroid glands / Walter C. Bell -- Uncommon and relatively uncommon lesions of the female reproductive system / Michael G. Conner -- Who is who among urothelial neoplasms? / Katrin M. Klemm -- Diverticular colitis / Audrey J. Lazenby -- Molecular markers in breast cancer: current practice and future possibilities / Thomas Winokur -- Cytology and surgical pathology of the mediastinum / Claudia Y. Castro and David C. Chhieng -- Cytology and surgical pathology of pleural cavities / Claudia Y. Castro and David C. Chhieng -- Cytology and surgical pathology of neoplasms of the lung / Claudia Y. Castro and David C. Chhieng -- Endoscopic ultrasound guided fine needle aspiration of the pancreas / Darshana Jhala and Nirag C. Jhala -- Using imaging data in making orthopedic diagnoses / Michael J. Klein -- Selected case studies in hematopathology: application of current ancillary techniques in diagnosis / Vishnu V. Reddy -- Aggressive B-cell lymphomas / Wei Yang and Catherine M. Listinsky -- Demystifying the diagnosis of gliomas / Cheryl Ann Palmer -- Odontogenic tumors for general pathologists / Nasser Said-Al-Naief -- Effective communication of antimicrobial susceptibility data by pathologists to clinicians / Ken B. Waite -- Acquisition and use of digital images for pathology education and practice / Kristina T.C. Panizzi, Kristopher N. Jones, and Peter G. Anderson.
    Also available: Print – 2005
  • 2014 Springer
    Brendon J. Coventry, editor.
    Written by internationally acclaimed specialists,"Upper Abdominal Surgery" provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated with photographs that depict anatomic or technical principles.
  • 2005 Springer
    John W.L. Fielding and Michael T. Hallissey, [editors].
  • 2015 Springer
    Shahrokh F. Shariat, Evanguelos Xylinas, editors.
    Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. Its aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage andpatient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy are covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists, and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
  • 2015 Springer
    Michael Grasso III, Demetrius H. Bagley, editors.
    Upper tract urothelial carcinoma : ureteroscopic biopsy and specimen preparation / Demetrius H. Bagley, Ryuta Tanimoto, and Kelly A. Healy -- Imaging of upper tract transitional cell carcinoma / Sarah L. Steenbergen and Gary Israel -- Cytopathology and management of ureteroscopic biopsy samples / Shuye Ren and Marluce Bibbo -- Ureteroscopic treatment of upper urinary tract urothelial malignancy / Michael Grasso III, Bobby S. Alexander, Lynn J. Paik, and Andrew I. Fishman -- Surgical management of upper tract urothelial carcinoma- open, laparoscopic, and robotic approaches to nephroureterectomy and outcomes / Marc J. Mann, Costas D. Lallas, and Edouard J. Trabulsi -- Surveillance after treatment for upper tract transitional cell carcinoma / Michael J. Conlin and Brian D. Duty -- Topical chemotherapy / John Michael Henderson and Francis X. Keeley Jr. -- Systemic chemotherapy for upper tract urothelial cancer / Jean Hoffman-Censits -- Hereditary upper tract urothelial carcinoma : Lynch syndrome, hereditary nonpolyposis colorectal cancer syndrome (HNPCC) / Scott G. Hubosky and Bruce M. Boman -- Bladder tumors : association with upper tract neoplasms / Christopher B. Anderson, John E. Musser, John P. Sfakianos, and Harry W. Herr -- Enhanced imaging : NBI, PDD, SPIES / Luca Villa, Jonathan Cloutier, and Olivier Traxer -- Beyond endoscopy- ultrasound, optical coherence tomography and confocal laser endomicroscopy / Mieke T.J. Bus, Daniel Martin de Bruin, Guido M. Kamphuis, Theo M. de Reijke, and Jean J.M.C.H de la Rosette -- Diagnostic and treatment algorithm of upper tract urothelial carcinoma / Andrew I. Fishman, Lynn J. Paik, and Michael Grasso III.
  • UpToDate (Firm)
    Mobile Application, UpToDate for iOS Users must register through the campus network, download the app, and sign in.
    Rose, Burton David.
    UpToDate is a web-based, clinical information resource, designed to provide concise, practical answers to clinical questions. The content is updated quarterly. Nearly 3,000 author physicians continually review the literature for material that is well supported by data and would be useful in a clinical setting. If a medical finding is deemed important, it is then added to the relevant topic review(s) after approval by an internal peer review and by the authors. The content is comprehensive, concise, and fully referenced.
  • 2015
    RAND Corporation, Lisa M. Sontag-Padilla, Rachel M. Burns, Regina A. Shih, Beth Ann Griffin, Laurie T. Martin, Anita Chandra ; University of Tennessee Health Science Center, Frances Tylavsky.
    Machine generated contents note: ch. One Introduction -- The Importance of Examining Early-Childhood Cognitive and Behavioral Development -- The Urban Child Institute and the History of the CANDLE Study -- Purpose of This Report -- Structure of the Report -- ch. Two Study Design and Methods -- Study Design -- Eligibility -- Recruitment -- Data Collection -- Study Population -- Analytic Sample and Attrition over Time -- Approach to Weighting the CANDLE Sample -- Sample Characteristics -- Sample Characteristics Used for Weighting (Age, Race, Education, Income) -- Other Demographic Characteristics of the Mothers in the Sample -- Demographic Characteristics of the Child's Father -- Measures -- ch. Three Prenatal and Birth Measures -- Maternal Baseline Enrollment Data Form -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Labor and Delivery Form -- Background -- Description -- Administration -- Scoring -- Data -- Neonatal Summary Form -- Background -- Description -- Administration -- Data -- ch. Four Child and Family Health -- Child Health Update Form -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Sleep Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Family Health History -- Background -- Description -- Administration -- Data Notes -- Data -- Residence Establishment and Lead Risk Assessment -- Background -- Description -- Administration -- Data Notes -- Data -- Child Exam -- Background -- Description -- Administration -- Data Notes -- Data -- Children with Special Health Care Needs Screener -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Five Child and Family Nutrition -- Block Food Frequency Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Choline Inhibitor Questionnaire -- Background -- Description -- Administration -- Data Notes -- Infant Feeding Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Food Supplement Information -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Six Mother's Mental and Behavioral Health -- Temperament Evaluation of Memphis, Pisa, Paris, and San Diego -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Brief Symptom Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Rosenberg Self-Esteem Scale -- Background -- Description -- Administration -- Data Notes -- Data -- Edinburgh Postnatal Depression Scale -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Seven Cognitive Performance -- Bayley Scales of Infant Development -- Background -- Description -- Administration -- Data Notes -- Data -- Wechsler Abbreviated Scale of Intelligence -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Eight Psychosocial Measures -- Conflict Tactics Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Traumatic Life Events Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Social Support Questionnaire, 6th Edition -- Background -- Description -- Administration -- Data Notes -- Data -- Knowledge of Infant Development Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Household Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Child Abuse Potential Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Parenting Stress Index Short Form -- Background -- Description -- Administration -- Data Notes -- Data -- Parent-Child Interaction Nursing Child Assessment Satellite Training Teaching Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Child Care Information -- Background -- Description -- Administration -- Data Notes -- Data -- Scales of Independent Behavior -- Revised -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Toddler Social Emotional Assessment -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- ch. Nine Implications and Potential Benefits for the CANDLE Study -- Appendix. Biological Samples -- Biologic Measures -- Biological Lead Substudy.
  • 2014 Springer
    Baoxue Yang, Jeff M. Sands, editors.
    The mechanisms and physiological functions of urea transport across biological membranes are subjects of long-standing interest. Recent advances in the molecular biology and physiology of urea transport have yielded new insights into how and why urea moves across cell membranes. In the last two decades, seven facilitated urea transporters (UT-A1-6 and UT-B) have been cloned, and their gene organization, protein crystal structure, expression localization and physiological functions in the tissues have been described. In recent years, the studies in urea transporter knockout mouse models suggest that urea transporters may be useful targets for drug discovery of selective inhibitors. The modulation of urea transport activity by pharmacological agents may provide novel treatments for hypertension, congestive heart failure and other fluid-retaining states. However, although urea represents about 40% of all urinary solutes in normal human urine, the handling of this solute in the tissues has been largely neglected in the past, and few clinical or experimental studies now report data about urea. Most recent physiological textbooks include chapters on water and electrolyte physiology but not a single chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into further mechanisms and the physiological significance of urea metabolism and transport in mammals. The book provides a state-of-the-art report on the latest findings on urea transport and where the field is going. Although some older work is cited, the main focus is on advances made over the past 20 years with regard to the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. These aspects are especially valid, as advances in our understanding of urea transporting mechanisms and physiology promise to yield new insights into biology and medicine.
  • 2015 Springer
    Sutchin R. Patel, Stephen Y. Nakada.
    Providing a complete updated roadmap to treating ureteral stones, Ureteral Stone Management: A Practical Approach presents newer topics focusing of the recent improvements in instrumentation and adjunctive equipments, managing radiation to both patient and urologist, as well as reviews of the most recent studies on urologic practices. Ureteral Stone Management: A Practical Approach assists the reader in a logical and step wise pathway for selecting the best treatment options and how to work through complications. This evidence-based text is valuable to all those working in the field of urology.
  • 2010 Springer
    Saverio Pagano ; con la collaborazione di Paolo Rovellini e Pantaleo Ruggeri ; presentazione a cura di Giuseppe Martorana.
  • 2013 Springer
    Manoj Monga, editor.
    Ureteroscopy: Indications, Instrumentation & Technique provides a comprehensive and state-of-the-art review of ureteroscopy and will serve as a valuable resource for urologists throughout the world. The volume provides evidence based outcomes to support the expanding indications for ureteroscopy as well as a strong emphasis on appropriate patient selection. The book also provides detailed recommendations for the step-by-step approach to ureteroscopy from both an instrumentation and techniques perspective. The work is extensively illustrated with endoscopic images and includes a DVD of video clips which further highlight the clinical application of available endoscopic techniques. The text also includes highly practical presentations of complex endourologic case presentations with expert analysis and editorial commentary. Example cases would include common but challenging cases of ureteroscopy for transitional cell cancer, horseshoe kidneys, hutch diverticulum, and pregnancy. Ureteroscopy: Indications, Instrumentation & Technique provides a unique and valuable resource in the field of ureteroscopy and will include basic instructions for those currently in training or those who have yet to adapt intrarenal ureteroscopy into their surgical armamentarium. Advanced ureteroscopic approaches are also covered for those wishing to enrich their current clinical expertise.
  • 2006 Springer
    [edited by] F. Schreiter and G.H. Jordan.
    1. Introduction / F. Schreiter, G.H. Jordan -- 2. Historical highlights in the development of urethral surgery / K. Bandhauer -- 3. Anatomy and blood supply of the urethra and penis / J.K.M. Quartey -- 4. Fundamentals and principles of tissue transfer / G.H. Jordan, K. Rourke -- 5. Tissue engineering: the future of urethral reconstructive surgery? / K.D. Sievert -- 6. Hypospadia repair: the past and the present - also the future? / R. Hohenfellner -- 7. Urethral reconstruction in women / E.J. McGuire -- 8. A Current overview of the treatment of urethral strictures: etiology, epidemiology, pathophysiology, classification, and principles of repair / S.M. Schlossberg -- 9. The Acute posterior urethral injury / J. Latini, J.T. Stoffel, L. Zinman -- 10. The endoscopic treatment of post-traumatic membranous urethral strictures / V. Pansadoro, P. Emiliozzi -- 11. Endoscopic realignment of post-traumatic membranous urethral disruption / V. Pansadoro, P. Emiliozzi -- 12. The Role of bouginage, visual urethrotomy, and stents today / H. Sperling, M. Goepel, H. Rübben -- 13. Alternative endourological techniques in the treatment of urethral strictures: review of the current literature / E. Geist, R. Hartung -- 14. Reconstruction of the bulbar and membranous urethra / F. Schreiter, B. Schönberger, R Olianas -- 15. The Sagittal posterior (transcoccygeal transrectal transsphincteric) approach for reconstruction of the posterior urethra / D. Streit -- 16. The Use of flaps in urethral reconstructive surgery / G.H. Jordan, K.F. Rourke -- 17. Reconstruction of the fossa navicularis / G.H. Jordan, K.F. Rourke -- 18. Penile circular fasciocutaneous flaps for complex anterior urethral strictures / K.J. Carney, J.W. McAninch -- 19. Selective use of the perineal artery fasciocutaneous flap (Singapore) in urethral reconstruction / L. Zinman -- 20. Anterior urethral stricture repair and reconstruction in hypospadias cripples / F. Schreiter, B. Schönberger -- 21. The Use of free grafts for urethroplasty / D.E. Andrich, A.R. Mundy -- 22. Repair of bulbar urethra using the Barbagli technique / G. Barbagli, M. Lazzeri -- 23. Indications and limitations of buccal mucosa reconstructive urethral surgery in hypospadias repair / M. Fisch -- 24. Indications and limits for the use of boccal mucosa for urethral reconstruction / D. Kröpfl, A. Verweyen -- 25. Two-stage mesh-graft urethroplasty / F. Schreiter.
  • 2008 Springer
    edited by Steven B. Brandes.
  • 2009 Springer
    sous la direction de Jean-Paul Beregi ; avec la collaboration des membres de la SFICV.
  • 2008
    Susan King Strasinger, Marjorie Schaub Di Lorenzo.
    Status: Not Checked OutLane Catalog Record
  • 2005 Springer
    Horst-Dieter Becker ... [et al.], editors.
  • 2016 Springer
    Jaspreet S. Sandhu, editor.
    1. Introduction: urinary function alterations in men with prostate cancer -- 2. Post-prostatectomy incontinence initial evaluation -- 3. Urinary incontinence: conservative and medical management and injectable therapy -- 4. Urinary dysfunction in prostate cancer: male slings -- 5. Artificial urinary sphincter: patient selection and surgical technique -- 6. Troubleshooting and optimizing outcomes after artificial urinary sphincter -- 7. Management of vesicourethral anastomotic stricture -- 8. Rectourethral fistula -- 9. Reoperative anti-incontinence surgery -- 10. Post-RT urinary incontinence and stricture -- 11. A case-based illustration of urinary symptoms following radiation therapy for prostate cancer -- Index.
  • 2007 Springer
    edited by Marshall L. Stoller, Maxwell V. Meng.
  • 2011 Springer
    Karl-Erik Andersson, Martin C. Michel, editors.
    The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike.
  • 2012 Springer
    Donna E. Hansel, Jesse K. McKenney, Andrew J. Stephenson, Sam S. Chang, editors.
    Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.
  • 2013 Springer
    Abhay Rané, Ranan Dasgupta, editors.
    The causative organisms of Urinary Tract Infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treatment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Urinary Tract Infections addresses key questions facing physicians about this condition. This book is written primarily for general physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also find the book useful as a quick reference guide.
  • 2011 Springer
    Nagaraja P. Rao, Glenn M. Preminger, John P. Kavanagh, editors.
    This book constitutes more than a quarter of urologists, workload in the Western countries and is more than half in the Middle-East and Central Asian countries. The surgical management of stone disease has changed considerably in the last five years and our understanding of mechanism of stone disease has improved with some old concepts discarded and newer theories gaining ground. Covering the entire spectrum of urinary stone disease and with contributions of more than fifty internationally recognised experts, this exhaustive and complex reference work will be invaluable to all urologists, nephrologists and non-medical scientists.
  • 2015 Springer
    Youhe Gao, editor.
    This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".
  • 2006 Springer
    Paul Abrams.
  • 2008 Thieme Book
    Bernd Hamm [and others] ; [translator, Bettina Herwig].
  • 2006 Springer
    Kate H. Moore.
  • 2013 Springer
    Kate H. Moore.
    Taking the history -- Physical examination -- How to manage the patient after history and examination -- How to conduct urodynamic studies: essentials of a good urodynamic report -- Outcome measures used to assess response -- Conservative therapy of urodynamic stress incontinence -- Step-by-step guide to treatment of overactive bladder (OAB)/Detrusor overactivity -- Anal incontinence and disorders of obstructive defecation -- Surgery for urodynamic stress incontinence -- Management of prolapse -- Recurrent bacterial cystitis in women -- Interstitial cystitis.
  • 2015 ClinicalKey
    [edited by] Mark D. Walters, Mickey M. Karram.
    Historical milestones in female pelvic surgery, gynecology, and female urology -- Anatomy of the lower urinary tract, pelvic floor, and rectum -- Embryology and congenital anomalies of the urinary tract, rectum, and female genital system -- Neurophysiology and pharmacology of the lower urinary tract -- Physiology of the pelvic muscles, vagina, and anorectum -- Female sexual function and dysfunction : assessment and treatment -- Epidemiology and psychosocial impact of female pelvic floor disorders -- Description and classification of lower urinary tract dysfunction and pelvic organ prolapse -- Evaluation of urinary incontinence and pelvic organ prolapse : history, physical examination, and office tests -- Urodynamics : indications, techniques, interpretation, and clinical utility -- Video and ambulatory urodynamics -- Endoscopic evaluation of the lower urinary tract -- Radiologic studies of the lower urinary tract and pelvic floor -- Neurophysiologic testing for pelvic floor disorders -- Pathophysiology of urinary incontinence -- Obstetrics and pelvic floor disorders -- Stress urinary incontinence and pelvic organ prolapse : nonsurgical management -- Retropubic operations for stress urinary incontinence -- Biologic bladder neck sling for stress urinary incontinence -- Synthetic midurethral slings for stress urinary incontinence -- Laparoscopic and robotic surgery for pelvic organ prolapse and stress urinary incontinence -- Urethral injection of bulking agents for intrinsic sphincter deficiency -- Surgical treatment of anterior vaginal wall prolapse -- Surgical treatment of rectocele and perineal defects -- Surgical treatment of vaginal apex prolapse -- Uterine conservation for the surgical treatment of uterovaginal prolapse -- Obliterative procedures for pelvic organ prolapse -- The use of biologic tissue and synthetic mesh in urogynecology and reconstructive pelvic surgery -- Avoiding and managing lower urinary tract injuries during pelvic surgery -- Managing mesh and other complications after surgeries for urinary incontinence and pelvic organ prolapse -- Fecal incontinence -- Constipation -- Rectovaginal fistula and perineal breakdown -- Rectal prolapse -- Overactive bladder syndrome and nocturia -- Hypersensitivity disorders of the lower urinary tract -- Surgical management of detrusor compliance abnormalities -- Voiding dysfunction and urinary retention -- Lower urinary tract infection -- Urethral diverticula -- Lower urinary tract fistulas -- The effects of gynecologic cancer on lower urinary tract function -- Bladder drainage and urinary protective methods -- Outcomes and quality-of-life measures in pelvic floor research -- The standardization of terminology of lower urinary tract function recommended by the international continence society -- The standardization of terminology of lower urinary tract function: report from the standardization subcommittee of the international continence society -- Standardization reports of the international continence society (ICS) -- Classification system of vaginal prostheses and graft complications recommended by the International Urogynecological Association (IUGA) and International Continence Society (ICS) -- Sample questionnaires for several recommended outcome measures for women with pelvic floor disorders.
  • 2007
    [edited by] Mark D. Walters, Mickey M. Karram.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Patrick J. Culligan and Roger P. Goldberg (eds).
  • 2014 Springer
    Michael E. Moran.
    Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.
  • 2012 Springer
    Jamsheer J. Talati, Hans-Goran Tiselius, David M. Albala, Zhangqun Ye, editors.
    Urolithiasis: Basic Science and Clinical Practice is a comprehensive text that assists urologists in defining the best choice of treatment for each case through a balanced presentation of underlying science, diagnostic methods and practical tips, with additional discussions on educational issues, costs and management of resources. This user-friendly practical resource is replete with full-color illustrations and radiographs, covering all aspects of stone disease, and offering perspectives from Europe, the Americas, China, South Asia, Africa, and Australia. Topics include the biochemical and physiological basis of stone formation, treatment options, complications, assessment of techniques and technologies available, and guidelines on the prevention of stone recurrence. Urolithiasis: Basic Science and Clinical Practice is the definitive text on stone disease and is a must read for young consultants starting a new practice, and urologists in residence and training.
  • 2009
    authors, Robert O. Petersen, Isabell A. Sesterhenn, Charles J. Davis, Jr.
    Status: Not Checked OutLane Catalog Record
    Kidney -- Renal pelvis and ureter -- Urinary bladder -- Urethra -- Testis -- Testicular adnexa -- Prostate -- Seminal vesicles -- Penis -- Scrotum.
  • 2008 Springer
    edited by Jeffrey A. Stock, Michael P. Esposito, Vincent J. Lanteri ; foreword by David M. Albala.
  • 2008 Springer
    Prokar Dasgupta, editor ; foreword by James O. Peabody and Mani Menon.
  • 2010 ClinicalKey
    [edited by] John B. Gebhart ; illustrated by Joe Chovan.
    Anatomy of the female urinary tract / John A. Occhino, Christine A. Heisler, and John B. Gebhart -- Imaging of the female urinary tract / Bohyun Kim, John B. Gebhart, and Akira Kawashima -- Cystourethroscopy for the gynecologist / Gamal M. Ghoniem and John B. Gebhart -- Reconstructive procedures performed on the urethra / John B. Gebhart -- Surgical procedures performed on the urinary bladder / Christopher J. Klingele and John B. Gebhart -- Avoiding and managing ureteral injury during pelvic surgery / Emanuel C. Trabuco and John B. Gebhart.
  • 2008
    [edited by] David G. Bostwick, Liang Cheng.
    Status: Not Checked OutLane Catalog Record
  • 2014 ClinicalKey
    [edited by] David G. Bostwick, Liang Cheng.
    Nonneoplastic disease of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Gregory T. MacLennan and Liang Cheng -- Renal pelvis and ureter / Stephen M. Bonsib and Liang Cheng -- Fine needle aspiration of the kidney / Andrew A. Renshaw -- Nonneoplastic disorders of the urinary bladder / Robert H. Young -- Neoplasms of the urinary bladder / Liang Cheng, Antonio Lopez-Beltran, Gregory T. MacLennan, Rodolfo Montironi, and David G. Bostwick -- Urine cytology / Deloar Hossain, David Hull, and David G. Bostwick -- Nonneoplastic diseases of the prostate / David G. Bostwick, David Hull, Jun Ma, and Deloar Hossain -- Neoplasms of the prostate / David G. Bostwick, Liang Cheng, and Isabelle Meiers -- Seminal vesicles / David G. Bostwick -- Urethra / Victor E. Reuter -- Nonneoplastic diseases of the testis / Manuel Nistal, Ricardo Paniagua, and Pilar Gonzalez-Peramato -- Neoplasms of the testis / Thomas M. Ulbright and Robert E. Emerson -- Spermatic cord and testicular adnexae / David G. Bostwick -- Penis and scrotum / Jae Y. Ro, Mukul Divatia, Kyu-Rae Kim, Mahul B. Amin, and Alberto G. Ayala -- Adrenal glands / Ernest E. Lack and Edina Paal.
  • 2015 Springer
    Said Abdallah Al-Mamari, Salim Said Al-Busaidy, editors.
    Part 1. Prostate Cancer -- 1. Epidemiology, Etiological factors, Prevention -- 2. PSA Biology and Prostate Cancer Screening -- 3. Symptoms, Signs, Clinical Examination, Primary Diagnostic Methods and Disease Extention Investigations -- 4. Prostate Cancer Treatment.- Part 2. Bladder tumour -- 5. Epidemiology, Pathology, Etiological factors, Prevention, Screening, Symptoms and Signs -- 6. Investigations (Lab and Radiology) -- 7. Bladder Tumour Treatment -- 8. Non-Urothelial Bladder Cancers -- Part 3. Upper Tract Urothelial Carcinomas -- 9. Epidemiology, Risk Factors, Pathology, Tumour Staging -- 10. Diagnosis of UTUC -- 11. Treatment of UTUC, Prognosis and Follow-Up -- Part 4. Renal Cell Carcinomas -- 12. Epidemiology, Etiology -- 13. Pathology, Genetic Profile, Hereditary Syndromes -- 14. Clinical Features -- 15. Physical Examination, Laboratory and Radiological Investigations -- 16. Treatment of Renal Cell Carcinomas.- Part 5. Male Genital Cancer -- 17. Epidemiology and Etiology of Testicular Cancer -- 18. Histological Classification of Testicular Cancer -- 19. Clinical Presentation of Testicular Tumours and Spreading Patterns.- 20. Diagnostic Approaches of Testicular Cancer -- 21. Staging and Risk Categories of Testicular Cancer -- 22. Treatment of Testicular Cancer -- 23. Extra-Gonadal Germ Cell Tumours -- 24. Penile Cancer.- Part 6. Adrenal Gland Cancer -- 25. Epidemiology, Aetiological Factors, Symptoms and Signs of Adrenocortical Carcinomas (ACC) -- 26. Investigations of ACC -- 27. Treatment of Adrenal Gland Cancer -- 28. Malignant Pheochromocytoma -- Part 7. Clinical Scenarios -- 29. Scenarios and Questions -- 30. Proposed Answers.
  • 2005 Springer
    Jonathan Waxman (ed.).
  • 2007 Springer
    Jonathan Waxman (ed.).
  • 2013 Springer
    Hunter Wessells, editor.
    Urological Emergencies: A Practical Approach, Second Edition provides a concise, evidence based review of common urgent and emergent urological conditions in children and adults. Descriptions of the appropriate diagnostic and therapeutic considerations on topics of traumatic, infectious, obstructive, hemorrhagic, iatrogenic, vascular and congenital urological emergencies in adults and children are provided. The text is organized by pathophysiology rather than organ system, allowing the reader to develop approaches to the care of patients with acute urological conditions based on mechanism of disease. Relevant pathophysiological background and epidemiology are reviewed, necessary diagnostic testing recommended, and detailed medical, surgical and endourological management approaches have been provided. All chapters incorporate published guidelines and best practice recommendations from appropriate organizations including the American Urological Association, the Centers for Disease Control and Prevention, and various International Consultations on Urological Diseases. New or significantly revised chapters in each of the subsections address innovations in trauma care and prevention, new strategies in management of kidney stones, and special care needs of children with acute urological problems. Urological Emergencies: A Practical Approach, Second Edition is of great value to practicing urologists, urology residents, emergency medicine trainees and practitioners, and primary care providers including MD's, PA's, and NP's without immediate access to urological consultation.
  • 2013 Springer
    Armenakas, Noel; Cowan, Nigel C.; Hashim, Hashim; Reynard, John; Wood, Dan.
    Presenting Symptoms of Urological Emergencies / Hashim Hashim -- Lower Urinary Tract Emergencies / John Reynard -- Nontraumatic Renal Emergencies / John Reynard -- Other Infective Urological Emergencies / Hashim Hashim -- Traumatic Urological Emergencies / Noel Armenakas -- Scrotal and Genital Emergencies / John Reynard -- Postoperative Emergencies After Urological Surgery / Hashim Hashim -- Ureteric Colic in Pregnancy / Dan Wood -- Management of Urological Neoplastic Conditions Presenting as Emergencies / Dan Wood -- Pediatric Emergencies / Dan Wood -- Common Emergency Urological Procedures / John Reynard.
  • 2012 Springer
    editor: Daniel A. Shoskes.
    Evidence-Based and Age-Appropriate Preventive Health Evaluations in Men / Raul J. Seballos -- Clinical Testing of Endothelial Function in Erectile Dysfunction / Titte R. Srinivas and Mark S. Segal -- Controversies and Opportunities for PSA Screening / Benjamin Cohen and Eric A. Klein -- A Phenotypic Approach to the Evaluation and Treatment of Men with Chronic Pelvic Pain Syndrome / Kiranpreet Khurana and Daniel A. Shoskes -- Recurrent Urinary Tract Infections in Men / Stacey C. Carter, Mya E. Levy and Scott I. Zeitlin -- Evaluation and Medical Management of BPH and LUTS in Men / Bilal Chughtai, Richard Lee, Matthew Hall and Alexis E. Te -- The Surgical Treatment of Benign Prostatic Hyperplasia / James C. Ulchaker -- Rational Herbal and Complementary Interventions for Prevention and Treatment of Urological Disorders in Men / Mark A. Moyad -- Androgen Decline in the Aging Male: Making Sense of the "Male Menopause" / Daniel A. Shoskes -- Evaluation and Treatment of Peyronie's Disease / Lawrence S. Hakim -- Primary Care Evaluation and Treatment of Erectile Dysfunction / Martin Miner and Jacob Rajfer -- Surgical Treatment for Erectile Dysfunction / Drogo K. Montague -- Managing Overactive Bladder and Urinary Incontinence in the Male / Humphrey Atiemo and J. Quentin Clemens -- Treatment of Localized Prostate Cancer / Andrew J. Stephenson -- Management of Urethral Strictures in Men / Richard A. Santucci and Mang L. Chen -- Medical and Surgical Interventions in Male Fertility / Kevin Chandler and Edmund Sabanegh Jr. -- Evaluation and Therapy of Chronic Scrotal Content Pain and Epididymitis / Jonas S. Benson and Laurence A. Levine -- Psychosocial Factors in Painful Urogenital Conditions in Men / Dean A. Tripp and Jessica Ginting.
  • 2015 Springer
    V.H. Nargund, D. Raghavan, H.M. Sandler, editors.
    With a fully updated look at urological cancers and a comprehensive approach to the basic principles behind chemotherapy, radiotherapy and gene therapy, Urological Oncology, 2nd Edition addresses the advances in MRI, hormone therapy, anesthesia for minimally invasive surgery, drug trials, new therapeutic techniques as well as the new histological types of renal cancer, bringing this second edition fully up-to-date with current practices. Through investigations and multidisciplinary management, Urological Oncology, 2nd Edition reflects the editors? vast experience in treating all urological cancers, and the broad international contributions reflect the urological oncology practice in other developed countries including the United States. Urological Oncology, 2nd Edition will be a valuable tool for residents, specialists, nurse practitioners and other medical personnel in Urology, Radiotherapy, Oncology and Palliative Medicine involved in the treatment of urological cancers.
  • 2008 Springer
    Vinod H. Nargund, Derek Raghavan, and Howard M. Sandler (eds.).
  • 2007 Springer
    Nagaraja P. Rao, Shalom J. Srirangam, and Glenn M. Preminger.
  • 2014 Springer
    Axel S. Merseburger, Markus A. Kuczyk, Judd W. Moul, editors.
    Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds, and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations, many of them in color, are also included. The editors and authors are leading urological surgeons and oncologists and internationally recognized authorities in their fields. This book will be a great asset in every urologist?s office and will also prove invaluable for practitioners in related disciplines.
  • 2013 Ovid
    Michael T. Macfarlane, M.D., Louisville, Kentucky.
    The Fifth Edition of Urology in the House Officer Series creates a concise source of clinical information on urology for medical students and residents that can be easily carried for quick reference. Concentrating on the non-surgical aspects of urology, this pocket guide provides the information needed for making a diagnosis and deciding on the proper treatment course. This compact book is separated into two sections, the first, entitled Chief Presentations, covers the most common presenting complaints in the general urology clinic. The second section, entitled, Selected Topics, covers the major areas of urology in greater detail. Covering all diagnostic and treatment approaches for all urologic diseases, this pocket guide is also ideal for family practitioners, physician assistants, nurse practitioners, and emergency room physicians who wish to quickly review a specific urologic presentation.
  • 2006 Ovid
    Michael T. Macfarlane.
    Urinary retention -- Lower urinary tract symptoms -- Abnormal prostate-specific antigen or digital rectal examination -- Hematuria -- Incontinence -- Acute stone management -- Genitourinary pain -- Erectile dysfunction -- Penile complaints -- Scrotal mass -- Empty scrotum -- Urethral discharge -- Trauma -- Urologic emergencies -- Abdominal masses -- Ambiguous genitalia -- Urinary tract infections -- Sexually transmitted diseases -- Benign prostatic hyperplasia -- Urinary calculi -- Voiding disorders -- Prostate cancer -- Urothelial cancers -- Kidney tumors -- Adrenals -- Testicular cancer -- Cancer of urethra and penis -- Metabolic disorders -- Obstructive uropathy -- Renal failure -- Renovascular hypertension -- Pregnancy -- Interstitial cystitis -- Anomalies of the genitourinary tract -- Vesicoureteral reflux -- Diagnostic techniques.
    Also available: Print – 2006
  • 2012 ClinicalKey
    [edited by] Ming Zhou, George J. Netto, Jonathan I. Epstein.
    Nonneoplastic disease of the prostate -- Neoplastic disease of the prostate -- Seminal vesicles -- Nonneoplastic disease of the urinary bladder -- Neoplastic disease of the urinary bladder -- Nonneoplastic disease of the kidney -- Neoplastic disease of the kidney -- Renal pelvis and ureter -- Nonneoplastic disease of the testis -- Neoplastic disease of the testis -- Spermatic cord and testicular adnexa -- Disease of the penis, urethra, and scrotum -- Soft tissue tumors and lymphomas.
  • 2010 Springer
    [edited by] Torsten Zuberbier, Clive Grattan, Marcus Maurer.
    History of Urticaria / M. Greaves -- Aetiopathogenesis of Urticaria / Clive E. H. Grattan -- Classification of Urticaria / Torsten Zuberbier -- Impact of Urticaria: QOL and Performance / Ilaria Baiardini, Fulvio Braido and Giorgio Walter Canonica -- Acute Urticaria / Torsten Zuberbier -- Chronic Urticaria / Marcus Maurer -- Dermographic and Delayed Pressure Urticaria / Frances Lawlor -- Heat and Cold Urticaria / Carsten Bindslev-Jensen -- Solar Urticaria / Tatsuya Horikawa, Atsushi Fukunaga and Chikako Nishigori -- Cholinergic Urticaria and Exercise-Induced Anaphylaxis / Ruth A. Sabroe -- Contact Urticaria / Jürgen Grabbe -- Urticarial Syndromes and Autoinflammation / Kanade Shinkai and Kieron S. Leslie -- Urticaria Vasculitis / Lluís Puig -- Angioedema / Elena Borzova and Clive E. H. Grattan -- Therapy of Urticaria / Bettina Wedi -- Standard Operating Procedures: A Practical Approach / M. Metz and M Magerl.
  • 2009 NAP
    Committee on the U.S. Commitment to Global Health, Board on Global Health, Institute of Medicine of the National Academies.
    Summary -- Charge to the committee -- a prominent role for health in U.S. foreign policy -- Progress in global health can be achieved now -- Urgent opportunity for action -- Restructure the U.S. global health enterprise -- Mobilize financial resources for health -- Focus U.S. government efforts on health outcomes -- Advance U.S. strengths in global health knowledge -- Support and collaborate with the WHO -- Call to action.
  • 2009 NAP
    Committee on the U.S. Commitment to Global Health, Board on Global Health, Institute of Medicine of the National Academies.
    The U.S. Commitment to Global Health examines ways in which the United States could contribute to advances in global health, including the following four areas of action: Generate and share knowledge to address problems endemic to poor countries, Invest in people, institutions, and capacity building in resource-poor settings, Increase both quantity and quality of U.S. financial commitments to global health, Be a respectful partner and leader.
  • 1989- CDC, Scroll down to U.S. Decennial Life Tables for 1989 to 1991.
    no. 1. Alabama -- no. 2. Alaska -- no. 3. Arizona -- no. 4. Arkansas -- no. 5. California -- no. 6. Colorado -- no. 7. Connecticut -- no. 8. Delaware -- no. 9. District of Columbia -- no. 10. Florida -- no. 11. Georgia -- no. 12. Hawaii -- no. 13. Idaho -- no. 14. Illinois -- no. 15. Indiana -- no. 16. Iowa -- no. 17. Kansas -- no. 18. Kentucky -- no. 19. Louisiana -- no. 20. Maine -- no. 21. Maryland -- no. 22. Massachusetts -- no. 23. Michigan -- no. 24. Minnesota -- no. 25. Mississippi -- no. 26. Missouri -- no. 27. Montana -- no. 28. Nebraska -- no. 29. Nevada -- no. 30. New Hampshire -- no. 31. New Jersey -- no. 32. New Mexico -- no. 33. New York -- no. 34. North Carolina -- no. 35. North Dakota -- no. 36. Ohio -- no. 37. Oklahoma -- no. 38. Oregon -- no. 39. Pennsylvania -- no. 40. Rhode Island -- no. 41. South Carolina -- no. 42. South Dakota -- no. 43. Tennessee -- no. 44. Texas -- no. 46. Vermont -- no. 47. Virginia -- no. 48. Washington -- no. 49. West Virginia -- no. 50. Wisconsin-- no. 51. Wyoming.
    Also available: Print – v. 1-51, 1998.
  • 2013 NAP
    Panel on Understanding Cross-National Health Differences Among High-Income Countries ; Steven H. Woolf and Laudan Aron, editors ; Committee on Population, Division of Behavioral and Social Sciences and Education ; Board on Population Health and Public Health Practice, Institute of Medicine ; National Research Council and Institute of Medicine of the National Academies.
    "The United States is among the wealthiest nations in the world, but it is far from the healthiest. Although life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives and experience more injuries and illnesses than people in other high-income countries. The U.S. health disadvantage cannot be attributed solely to the adverse health status of racial or ethnic minorities or poor people: even highly advantaged Americans are in worse health than their counterparts in other, "peer" countries. In light of the new and growing evidence about the U.S. health disadvantage, the National Institutes of Health asked the National Research Council (NRC) and the Institute of Medicine (IOM) to convene a panel of experts to study the issue. The Panel on Understanding Cross-National Health Differences Among High-Income Countries examined whether the U.S. health disadvantage exists across the life span, considered potential explanations, and assessed the larger implications of the findings. U.S. Health in International Perspective presents detailed evidence on the issue, explores the possible explanations for the shorter and less healthy lives of Americans than those of people in comparable countries, and recommends actions by both government and nongovernment agencies and organizations to address the U.S. health disadvantage"--Publisher's description.
  • 2011 CRCnetBASE
    Michael E. Wiklund, Jonathan Kendler, Allison Y. Strochlic.
    "Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers, including marketers, engineers, and regulatory affairs specialists, are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to read it all in one sitting or jump from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protects against dangerous errors that could lead to patient injury and death"--Provided by publisher.
  • 2016 Springer
    Birgit Völlm, Norbert Nedopil, editors.
  • 2014 ScienceDirect
    edited by Jennifer A Doudna and Erik J Sontheimer.
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.
  • [By R. Bethene Ervin, Jacqueline D. Wright, and Jocelyn Kennedy-Stephenson].
  • 2007
    The Sexually Transmitted Diseases Diagnostics Initiatve.
    Status: Not Checked OutLane Catalog Record
  • NLM
    Sandra R. Wilson, Norma Starr-Schneidkraut, Michael D. Cooper ; submitted to Elliot R. Siegel.
  • 2008
    The Evidence-Based Medicine Working Group ; [edited by] Drummond Rennie ... [et al.].
    Status: Not Checked OutLane Catalog Record
    How to use the medical literature and this book to improve your patient care -- The philosophy of evidence-based medicine -- What is the question? -- Finding the evidence -- Why study results mislead: bias and random error -- Therapy -- Does treatment lower risk? Understanding the results -- Confidence intervals -- Advanced topics in the validity of therapy trials -- Hypothesis testing -- Advanced topics in applying the results of therapy trials -- Harm -- Advanced topics in harm -- The process of diagnosis -- Differential diagnosis -- Diagnostic tests -- Advanced topics in diagnosis -- How to critically appraise an article about prognosis -- Summarizing the evidence -- Advanced topics in systematic reviews -- How to use a patient management recommendation -- Advanced topics in moving from evidence to action.
  • 2016
    edited by Erika Dyck, Larry Stewart.
    The hermaphrodite of Charing Cross / Anita Guerrini -- Galvanic humans / Rob Iliffe -- The subject as instrument : galvanic experiments, organic apparatus and problems of calibration / Joan Steigerwald -- Shocking subjects : human experiments and the material culture of medical electricity in eighteenth-century England / Paola Bertucci -- Pneumatic chemistry, self-experimentation and the burden of revolution, 1780-1805 / Larry Stewart -- Food fights : human experiments in late nineteenth-century nutrition physiology / Elizabeth Neswald -- Experimenting with radium therapy : in the laboratory & the clinic / Katherine Zwicker -- Anthropometry, race, and eugenic research : "Measurements of growing Negro children" at the Tuskegee Institute, 1932-1944 / Paul A. Lombardo -- Nazi human experiments : the victims' perspective and the post-Second World War discourse / Paul Weindling -- A eugenics experiment : sterilization, hyperactivity and degeneration / Erica Dyck.
    Also available: Print – 2016
  • 2008 CRCnetBASE
    Hugh Cartwright ; chapter 10, Evolvable developmental systems, contributed by Nawwaf Kharma.
  • 2008 Springer
    edited by Mandy Ryan, Karen Gerard, Mabel Amaya-Amaya
    Dces: what are they and their application in health a user's guide -- Discrete choice experiments in a nutshell -- Designing discrete choice experiments for health care -- Practical issues in conducting a discrete choice experiment -- Comments on the design of the choice experiment -- Case studies in valuing health and health care -- Using discrete choice experiments to go beyond clinical outcomes when evaluating clinical practice -- Using discrete choice modeling to investigate breast screening participation -- Preferences for health care programmes: results from a general population discrete choice survey -- Examining the preferences of health care providers: an application to hospital consultants -- Methodological issues -- The price proxy in discrete choice experiments: issues of relevance for future research -- "Irrational" stated preferences: a quantitative and qualitative investigation -- Using stated preference and revealed preference data fusion modelling in health care -- Conclusions -- Concluding thoughts.
  • 2008 ScienceDirect
    edited by Christopher Kennard, R. John Leigh.
    Mapping the oculomotor system -- Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey -- Histochemical characterisation of trigeminal neurons that innervate monkey extraocular muscles -- Functional anatomy of the extraocular muscles during vergence -- Induced extraocular muscle afferent signals: from pigeons to people -- Monkey primary somatosensory cortex has a proprioceptive representation of eye position -- Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant -- Dynamic aspects of trochlear nerve palsy -- Ocular motor nerve palsies: implications for diagnosis and mechanisms of repair -- Extraocular proprioception and new treatments for infantile nystagmus syndrome. Neural circuits for triggering saccades in the brainstem -- Brainstem circuits controlling lid-eye coordination in monkey -- Defining the pupillary component of the periocular preganglionic population with in a unitary Edinger-Westphal nucleus -- Frontal eye field signals that may trigger the brainstem saccade generator -- The role of omnipause neurons: why glycine? -- Applying saccade models to account for oscillations -- Dynamics of saccadic oscillations -- Effects of failure of development of crossing brainstem pathways on ocular motor control -- Neuronal evidence for individual eye control in the primate cMRF. Complex spike activity signals the direction and size of dysmetric saccade errors -- Role of the MST-DLPN pathway in smooth pursuit adaptation -- Lesions of the cerebellar nodulus and uvula in monkeys: effect on otolith-ocular reflexes -- Vergence eye movement signals in the cerebellar dorsal vermis -- Oculomotor anatomy and the motor-error problem: the role of the paramedian tract nuclei -- Impulsive testing of semicircular canal function -- Inter-ocular differences of the horizontal vestibulo-ocular reflex during impulsive testing -- Control of ocular torsion in the rotational vestibulo-ocular reflexes -- Do humans how velocity-storage in the vertical rVOR? -- Preserved otolith function in patients with cerebellar atrophy and bilateral vestibulopathy -- Three-dimensional kinematics of saccadic eye movements in humans with cerebellar degeneration -- Inferior olive hypertrophy and cerebellar learning are both needed to explain ocular oscillations in oculopalatal tremor -- Impulsive head rotation resets oculopalatal tremor. Human ocular following: evidence that responses to large-field stimuli are limited by local and global inhibitory influences -- Short-latency disparity vergence eye movements -- MSTd neurons during ocular following and smooth pursuit perturbation -- Neural activity in cortical areas MST and FEF in relation to smooth pursuit gain control -- Eye position and cross-sensory learning both contribute to prism adaptation of auditory space -- Hysteresis effects of the subjective visual vertical during continuous quasi-static whole-body roll rotation -- Perception of self motion during and after passive rotation of the body around an earth-vertical axis -- The freezing rotation illusion -- Geometrical considerations on canal-otolith interactions during OVAR and Bayesian modelling -- Listing's plane and the otolith-mediated gravity vector -- A reinterpretation of the purpose of the translational vestibulo-ocular reflex in human subjects -- Dynamics of binocular fixation of targets during fore-aft motion -- Differential coding of head rotation by lateral-vertical canal convergent central vestibular neurons -- Cyclovergence evoked by up-down acceleration along longitudinal axis in humans -- Oblique gaze shifts: head movements reveal new aspects of component coupling -- Head movement control during head-free gaze shifts -- Postural changes during eye-head movements -- Cortical processing in vestibular navigation -- Foot rotation contribution to trunk and gaze stability during whole-body mediated gaze shifts -- Supraspinal locomotor control in quadrupeds and humans -- Private lines of cortical visual information to the nucleus of the optic tract and dorsolateral pontine nucleus -- Gravity perception in cerebellar patients. Brain mechanisms for switching from automatic to controlled eye movements -- The frontal eye field as a prediction map -- Volition and eye movements -- Negative motivational control of saccadic eye movement by the lateral habenula -- Eye movements as a probe of attention -- Using transcranial magnetic stimulation to probe decision-making and memory -- Supplementary eye field contributions to the execution of saccades to remembered target locations -- Multiple memory-guided saccades: movement memory improves the accuracy of memory-guided saccades -- Visual vector inversion during memory antisaccades -- Predictive signals in the pursuit area of the monkey frontal eye fields -- Internally generated smooth eye movement: its dynamic characteristics and role in randomized and predictable pursuit -- Predictive disjunctive pursuit of virtual images perceived to move in depth -- Tracking in 3-D space under natural viewing condition -- Exploring the pulvinar path to visual cortex -- The role of the human pulvinar in visual attention and action. How disturbed visual processing early in live leads to disorders of gaze-holding and smooth pursuit -- Manifest latent nystagmus: a case of sensori-motor switching -- Eye hyperdeviation in mouse cerebellar mutants is comparable to the gravity-dependent component of human downbeat nystagmus -- New insights into the upward vestibulo-oculomotor pathways in the human brainstem -- Mechanisms of vestibulo-ocular reflex (VOR) cancellation in spinocerebellar ataxia type 3 (SCA-3) and episodic ataxia type 2 (EA-2) -- Modelling drug modulation of nystagmus -- Aminopyridines for the treatment of cerebellar and ocular motor disorders -- Baclofen, motion sickness susceptibility and the neural basis for velocity storage -- Oculomotor deficits indicate the progression of Huntington's Disease -- Eye movements in visual search indicate impaired saliency processing in Parkinson's disease -- Ocular motor anatomy in a case of interrupted saccades -- Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease -- Conjugacy of horizontal saccades -- The neuroanatomical basis of slow saccades in spinocerebellar ataxia type 2 (Wadia-subtype) -- Selective, circuit-wide sparring of floccular connections in hereditary olivopontine cerebellar atrophy with slow saccades -- A quick look at slow saccades after cardiac surgery -- Eye and head torsion is affected in patients with midbrain lesions -- Horizontal saccadic palsy associated with gliosis of the brainstem midline.
  • 2009/2010
    Bernie Joseph Daigle, Jr.
    Status: Not Checked OutLane Catalog Record
  • 2007/2008
    Erik Jedediah Dean.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Alan Hunter Shain.
    Pancreatic ductal adenocarcinoma, subsequently referred to as pancreatic cancer, is one of the most deadly cancers with a five-year survival of only 5%. Typical treatment regimens include surgery and chemotherapy while targeted therapies are lacking. A better understanding of the underlying cancer biology may yield novel therapeutic targets. The field of genomics has transformed our ability to study cancer. Over the past two decades, microarray and sequencing based innovations have enabled biology to be carried out at the --omic scale (discussed further in Chapter 1). This dissertation employs --omic level analysis to query the differences between the pancreatic cancer genome and the normal human genome. First, high throughput structural characterizations were performed in order to annotate the mutated, rearranged, deleted, and amplified genes across seventy pancreatic cancers. These assays identified hundreds of candidate cancer genes. Among these candidates, SMURF1 was validated to be an oncogene (Chapter 2). Furthermore, various subunits of the SWI/SNF chromatin remodeling complex were validated to be tumor suppressor genes (Chapter 3). While SMURF1 and SWI/SNF were validated individually, the other candidates from structural studies were evaluated in parallel shRNA competive growth screen. From this, we characterize nine genes further -- some previously known to play a role in cancer and some novel (Chapter 4). The sum total of all of this work is a much deeper understanding of the biology of pancreatic cancer, yielding many novel therapeutic targets and hopefully allowing scientists to gain a foothold in the fight against this disease.
  • 2010 CRCnetBASE
    edited by Walter A. Korfmacher.
    Strategies and techniques for bioanalytical assays as part of new drug discovery / Walter A. Korfmacher -- The drug discovery process: from molecules to drugs / Mike S. Lee, Steven E. Klohr -- PK principles and PK/PD applications / Hong Mei, Richard A. Morrison -- Mass spectrometry for in vitro ADME screening / Inhou Chu -- Metabolite identification strategies and procedures / Ragu Ramanathan, S. Nilgün Çömezoǧlu, W. Griffith Humphreys -- Reactive metabolite screening and covalent-binding assays / Gérard Hopfgartner -- Fast metabolite screening in a discovery setting / Xiaoying Xu -- Fast chromatography with UPLC and other techniques / Sam Wainhaus -- Supercritical fluid chromatography-mass spectrometry / Yunsheng Hsieh -- Biomarkers of efficacy and toxicity: discovery and assay / Joanna R. Pols -- Imaging mass spectrometry for small molecules / Fangbiao Li -- MALDI IMS for proteins and biomarkers / Michelle L. Reyzer, Richard M. Caprioli -- Ambient ionization methods and their early applications in ADME studies / Jing-Tao Wu -- Pharmaceutical applications of accelerator mass spectrometry / Lan Gao, Swapan Chowdhury.
  • 2016 Springer
    H.G. Stratmann.
  • 2011 CRCnetBASE
    Nicholas J. Horton, Ken Kleinman.
    "R is a general purpose statistical software package used in many fields of research. It is licensed for free, as open-source software. The system has been developed by a large group of people, almost all volunteers"--Preface.
  • 2014 CRCnetBASE
    Victor A. Bloomfield.
    "The complex mathematical problems faced by scientists and engineers rarely can be solved by analytical approaches, so numerical methods are often necessary. There are many books that deal with numerical methods for scientists and engineers; their content is fairly standardized: solution of systems of linear algebraic equations and nonlinear equations, finding eigenvalues and eigenfunctions, interpolation and curve fitting, numerical differentiation and integration, optimization, solution of ordinary differential equations and partial differential equations, and Fourier analysis. Sometimes statistical analysis of data is included, as it should be. As powerful personal computers have become virtually universal on the desks of scientists and engineers, computationally intensive Monte Carlo methods are joining the numerical analysis armamentarium. If there are many books on these well-established topics, why am I writing another one? The answer is to propose and demonstrate the use of a language relatively new to the field: R. My approach in this book is not to present the standard theoretical treatments that underlie the various numerical methods used by scientists and engineers. There are many fine books and online resources that do that, including one that uses R: Owen Jones, Robert Maillardet, and Andrew Robinson. Introduction to Scientific Programming and Simulation Using R. Chapman & Hall/CRC, Boca Raton, FL, 2009. Instead, I have tried to write a guide to the capabilities of R and its add-on packages in the realm of numerical methods, with simple but useful examples of how the most pertinent functions can be employed in practical situations"-- Provided by publisher.
  • 2011 CRCnetBASE
    Ken Kleinman, Nicholas J. Horton.
    Chapter 1. Introduction to SAS -- Chapter 2. Data management -- Chapter 3. Common statistical procedures -- Chapter 4. Linear regression and ANOVA -- Chapter 5. Regression generalizations and multivariate statistics -- Chapter 6. Graphics -- Chapter 7. Advanced applications.
  • 2010
    Lora Beatrice Sweeney.
    The Drosophila olfactory system is an excellent model to study how neural circuits develop their complex structure and precise connectivity. Olfactory receptor neurons (ORNs) expressing the same odorant receptor, and thus sensing the same odorants, are scattered in the peripheral antenna and maxillary palp. Remarkably, these distributed ORNs expressing the same receptor converge their axons onto one discrete structural unit in the central brain termed a glomerulus. In each glomerulus, ORNs synapse with a single class of central projection neurons (PNs) that send their dendrites into one glomerulus and their axons to higher brain centers. Demonstrating this striking axonal specificity, the 1300 ORNs in the antenna expressing approximately 50 different odorant receptors segregate their axons into discrete 50 discrete glomeruli in the antennal lobe. This highly ordered olfactory circuit begs the question: how do ORN axons and PN dendrites achieve this remarkable level of convergence onto one of fifty glomeruli? My study of the Semaphorin protein family has revealed new cellular strategies for precise ORN axon and PN dendrite targeting. Semaphorins are highly conserved cell surface proteins that have been shown to function as neuronal "semaphores" to guide developing neurons. In ORNs, the transmembrane Sema-1a promotes axon-axon repulsion between two populations of ORNs to spatially restrict their targeting in the antennal lobe (Sweeney et al., 2007). In PNs, Sema-1a functions as a receptor to control PN dendrite targeting in a continuous molecular gradient (Komiyama et al., 2007). The secreted and highly homologous Sema-2a and Sema-2b produced by the ventromedial degenerating larval antennal lobe function in a countergradient as the Sema-1a ligand to repel dorsolateral PN dendrites (In preparation). Semaphorin function in Drosophila olfactory wiring demonstrates two novel strategies for neural circuit assembly: spatial cues from surrounding axons and from degenerating structures instruct precise targeting.
  • 2005 Springer
    by Susan B. Gerber, Kristin Voelkl Finn.
  • 2010
    Justin David Litchfield.
    Several methods of examining the structure and function of voltage-gated ion channels are described. The first part of this work involves synthetic small molecules based on the structure of (+)-saxitoxin, a marine neurotoxin. (+)-saxitoxin interacts with the pore of the voltage-gated sodium (NaV ) channel to prevent the passage of ions. A scaffold was designed to be modular, synthetically facile, and contain the functionality that had been implicated in the previous literature. Several members of this family of molecules were produced, and they were assayed for occlusion of sodium current (INa). The second part of this work examines the gating kinetics of voltage-gated potassium (KV) channels. 6-bromo-mercaptotryptamine (BrMT) is a marine neurotoxin that has been shown to alter the gating kinetics of KV channels. Specifically, BrMT affects the early, typically independent steps of KV gating by stabilizing the resting state of some number of the subunits. A family of small molecules was designed and synthesized that would examine the functional effects of different parts of the BrMT molecule. BrMT is a dimer containing three key functional groups: a halogenated indole, a pendant ethyl-amine, and a disulfide linker. Variance at all these positions was examined, and each had different effects. Notably, one of the variants, in which the disulfide linker was substituted for an oxy-bismethyl ether linker, affects KV gating in a different way from BrMT. Alternate models of gating in the presence of this novel analog are discussed.
  • 2008/2009
    Zhao Ying Pearline Teo.
    Status: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    edited by Sharon Srodin.
  • TRIAL ENDS January 1, 2017
  • 2011
    [authors, James White, Jack Wilson ; contributor, David Seiden].
    Status: Not Checked OutLane Catalog Record
    Section I. Histology and Cell Biology -- Section II. Early Embryology -- Section III. Gross Anatomy -- Section IV. Neuroscience -- Index.
  • 2011
    [author and executive editor, Steven R. Daugherty ; contributor, Alina Gonzalez-Mayo].
    Status: Not Checked OutLane Catalog Record
    Chapter 1. Epidemiology -- Chapter 2. Biostatistics -- Chapter 3. Life in the United States -- Chapter 4. Sustance abuse -- Chapter 5. Human sexuality -- Chapter 6. Learning and behavior modification -- Chapter 7. Defense mechanisms -- Chapter 8. Psychologic health and testing -- Chapter 9. Human development -- Chapter 10. Sleep and sleep disorders -- Chapter 11. Physician-patient relationship -- Chapter 12. Diagnostic and Statistical Manual IV (DSM IV) -- Chapter 13. Organic disorders -- Chapter 14. Psychopharmacology -- Chapter 15. Ethical and legal issues -- Appendix I. Health care delivery systems -- Index.
  • 2011
    [biochemistry author, Barbara Hansen, coauthors, Roger Lane, Sam Turco, David Seastone ; medical genetics author, Lynne B. Jorde, coauthors, Barbara Hansen, Vernon Reichenbecher].
    Status: Not Checked OutLane Catalog Record
    SECTION I. Molecular biology and biochemistry -- Chapter 1. Nucleic acid structure and organization -- Chapter 2. DNA replication and repair -- Chapter 3. Transcription and RNA processing -- Chapter 4. The genetic code, mutations, and translation -- Chapter 5. Regulation of eukaryotic gene expression -- Chapter 6. Recombinant DNA -- Chapter 7. Techniques of genetic analysis -- Chapter 8. Amino acids, proteins, and enzymes -- Chapter 9. Hormones -- Chapter 10. Vitamins -- Chapter 11. Overview of energy metabolism -- Chapter 12. Glycolysis and pyruvate dehydrogenase -- Chapter 13. Citric acid cycle and oxidative phosphorylation -- Chapter 14. Glycogen, gluconeogenesis, and the hexose monophosphate shunt -- Chapter 15. Lipid synthesis and storage -- Chapter 16. Lipid mobilization and catabolism -- Chapter 17. Amino acid metabolism -- Chapter 18. Purine and pyrimidine metabolism -- SECTION II. Medical genetics -- Chapter 1. Single-gene disorders -- Chapter 2. Population genetics -- Chapter 3. Cytogenetics -- Chapter 4. Genetics of common diseases -- Chapter 5. Gene mapping -- Chapter 6. Genetic diagnosis -- Index.
  • 2006
    [edited by] Tao Le, Vikas Bhushan, Kerry Dieberg, Robert W. Grow.
    Status: Not Checked OutLane Catalog Record
  • 2006
    [author, Steven R. Daugherty ; contributor, Judy A. Schwenker ... [et al.] ].
    Status: Not Checked OutLane Catalog Record
  • 2006
    [author, Elliott Wolfe ; content editors, Rochelle Rothstein ... [et al.] ; contributing editors, Lisa Mellor, Randi Bleier].
    Status: Not Checked OutLane Catalog Record
  • 2008
    [author, Elliott Wolfe ; content editors, Rochelle Rothstein ... [et al.] ; contributing editors, Lisa Mellor, Randi Bleier].
    Status: Not Checked OutLane Catalog Record
  • 2011
    [immunology author, Mary Ruebush ; microbiology author, Louise Hawley, coauthor, Mary Ruebush ; contributors, Thomas F. Lint, Kim Moscatello, Nancy Noben-Trauth].
    Status: Not Checked OutLane Catalog Record
    SECTION I. Immunology -- Chapter 1. Overview of the immune system -- Chapter 2. Cells of the immune system -- Chapter 3. The selection of lymphocytes -- Chapter 4. Lymphocyte recirculation and homing -- Chapter 5. The first response to antigen -- Chapter 6. The processing and presentation of antigen -- Chapter 7. The generation of humoral effector mechanisms -- Chapter 8. The generation of cell-mediated effector mechanisms -- Chapter 9. The generation of immunologic memory -- Chapter 10. Vaccination and immunotherapy -- Chapter 11. Immunodeficiency diseases -- Chapter 12. Acquired immunodeficiency syndrome -- Chapter 13. Diseases caused by immune responses: hypersensitivity and autoimmunity -- Chapter 14. Transplantation immunology -- Chapter 15. Laboratory techniques in immunology -- Appendix I. CD markers -- Appendix II. Cytokines -- Appendix III. Adhesion molecules -- Appendix IV. Mechanisms of resistance to microbial infections -- SECTION II. Microbiology -- Chapter 1. General microbiology -- Chapter 2. Medically important bacteria -- Chapter 3. Microbial genetics/drug resistance -- Chapter 4. Medically important viruses -- Chapter 5. Medically important fungi -- Chapter 6. Medical parasitology -- Chapter 7. Clinical infectious disease -- Chapter 8. Comparative microbiology -- Chapter 9. Flow charts/clue sheets -- Index.
  • 2009
    editors, Michael S. Manley, Leslie D. Manley.
    Status: Not Checked OutLane Catalog Record
    Contains 250 exam-style questions that do not appear in other Kaplan products.
  • 2011
    [authors, Henry Sanchez, John Barone ; contributors, Michael S. Manley, Dan Milner, Nancy Standler].
    Status: Not Checked OutLane Catalog Record
    Chapter 1. Fundamentals of pathology -- Chapter 2. Cellular injury and adaptation -- Chapter 3. Inflammation -- Chapter 4. Tissue repair -- Chapter 5. Circulatory pathology -- Chapter 6. Genetic disorders -- Chapter 7. Immunopathology -- Chapter 8. Amyloidosis -- Chapter 9. Principles of neoplasia -- Chapter 10. Environment- and lifestyle-related pathology -- Chapter 11. Skin pathology -- Chapter 12. Red blood cell pathology: anemias -- Chapter 13. Vascular pathology -- Chapter 14. Cardiac pathology -- Chapter 15. Respiratory pathology -- Chapter 16. Renal pathology -- Chapter 17. Gastrointestinal tract pathology -- Chapter 18. Pancreatic pathology -- Chapter 19. Gallbladder and biliary tract pathology -- Chapter 20. Liver pathology -- Chapter 21. Central nervous system pathology -- Chapter 22. Hematopoetic pathology- white blood cell disorders & lymphoid and myeloid neoplasms -- Chapter 23. Femal genital pathology -- Chapter 24. Breast pathology -- Chapter 25. Male pathology -- Chapter 26. Endocrine pathology -- Chapter 27. Bone pathology -- Chapter 28. Joint pathology -- Chapter 29. Skeletal muscle and peripheral nerve pathology -- Index.
  • 2011
    [author, Lionel P. Raymon ; coauthors, Craig Davis, Steven R. Harris ; contributors, Maris Victor Nora, Anthony Trevor].
    Status: Not Checked OutLane Catalog Record
    Section I. General principles -- Section II. Automonic pharmacology -- Section III. Cardiac and renal pharmacology -- Section IV. CNS pharmacology -- Section V. Antimicrobial agents -- Section VI. Drugs for inflammatory and related disorders -- Section VII. Drugs used in blood disorders -- Section VIII. Endocrine pharmacology -- Section IX. Anticancer drugs -- Section X. Immunopharmacology -- Section XI. Toxicology -- Index.
  • 2011
    [author, Robert B. Dunn ; contributors, Wazir Kudrath, Stanley S. Passo, L. Britt Wilson].
    Status: Not Checked OutLane Catalog Record
    Section I. Fluide distribution and edema -- Section II. Excitable tissue -- Section III. Skeletal muscle -- Section IV. Cardiac muscle mechanics -- Section V. Peripheral Circulation -- Section VI. Cardiac Cycle and Valvular Heart Disease -- Section VII. Respiration -- Section VIII. Renal Physiology -- Section IX. Acid-Base Disturbances -- Section X. Endocrinology -- Section XI. Gastrointestinal Physiology -- Index.
  • 2011
    Daugherty, Steven R.; Levy, Elissa; Manley, Leslie D.; Manley, Michael; Schwenker, Judy A.
    Status: Not Checked OutLane Catalog Record
    Coverage of the specific topics tested on the exam: Internal Medicine; Neurology; Obstetrics/Gynecology; Pediatrics; Psychiatry; and Surgery. In addition to fully preparing you for Step 3 with targeted practice, Kaplan also has strategies specific to the computer-based test.
  • 2014 ClinicalKey
    Theodore X. O'Connell.
    "An easy-to-read review perfect for busy students ... Review material quickly and easily thanks to bulleted lists, algorithms, illustrations, and a new 4-color section featuring key pathologic and clinical images ... Benefit from thorough revisions that ensure high-yield focus and most current overview of board-tested content."--Provided by publisher.
  • 2013 ClinicalKey
    Thomas A. Brown, Sonali J. Shah.
    "Get the most out of your study time with the popular and trusted USMLE Step 1 Secrets, 3rd Edition. With a clinical focus throughout, this easy-to-read book features questions and short answers, case scenarios to prepare you for the vignette-style USMLE exam, and a concise, integrated, clinical overview of Step 1 content. This bestselling USMLE review book is enjoyable to use and extremely effective for ensuring success on this high-stakes exam."--Publisher's website.
  • 2016 Springer
    Marwan Habiba, Giuseppe Benagiano, editors.
    1. History of Adenomyosis -- 2. The Incidence and Clinical Significance of Adenomyosis -- 3. The Pathophysiology of Adenomyosis -- 4. The Myometrium in Heath and Disease -- 5. The Role of the Myometrium in Adenomyosis -- 6. The Endometrium in Adenomyosis.- 7. The Animal Model of Adenomyosis -- 8. Improving the Preclinical Mouse Efficacy Studies of Adenomyosis -- 9. Adenomyosis and Ultrasound: the Role of Ultrasound and its Impact on Understanding the Disease -- 10. Adenomyosis and Endometrial Carcinoma -- 11. Myometrial Cystic Adenomyosis -- 12. Current Treatment for Adenomyosis.
  • 2009. Springer
    edited by Franco Muggia, Esther Oliva.
    Essential epidemiology of cancer of the endometrium -- Endometrial cancer: screening, diagnosis, and surgical staging -- Imaging in the diagnosis and treatment of endometrial cancer -- Uterine cancer: pathology -- Molecular pathology and cytogenetics of endometrial carcinoma, carcinosarcoma, and uterine sarcomas -- Prognostic factors in uterine cancer -- Primary hormonal therapy of endometrial cancer -- Early-stage endometrial cancer: surgery -- Early-stage endometrial cancer: radiation -- Therapeutic modalities in early-stage uterine papillary serous carcinomas, carcinosarcomas, clear-cell and mixed histology carcinomas: building a case for combined chemotherapy and radiation -- Treatment of advanced and recurrent carcinoma: hormonal therapy -- Treatment of advanced and recurrent carcinoma: chemotherapy -- Treatment for advanced and recurrent carcinoma: combined modalities -- Management of uterine sarcomas -- Future directions: new targets.
  • 2015 Springer
    Shalini Rajaram, K. Chitrathara, Amita Maheshwari, editors.
  • 2016 Springer
    Hideharu Kanzaki, editor.
  • 2015 Springer
    Andrea Tinelli, Antonio Malvasi, editors.
  • 2007/2008
    Matthew Pendleton Taylor.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Mari Iwamoto.
    The ability to make specific perturbations to biological molecules in a cell or organism is a central experimental strategy in modern research biology. Chemical approaches to probe biological function have greatly contributed to the understanding of protein functions. While small-molecule inhibitors offer rapid and reversible control of protein functions, identification and development of specific inhibitors for every protein of interest remains a challenge. In the past decade, numerous technologies have been developed that combine genetic with chemical methods to create conditional protein control systems with impeccable specificity. These systems include inducible protein localization using chemical inducer of dimerization, such as rapamycin, and inducible protein stabilization system such as our destabilizing domain (DD) technology previously developed by L. Banaszynski. Highly specific, high-affinity protein-ligand interactions are key to their effectiveness. In this thesis, three technologies that utilize highly specific protein-ligand interactions are discussed. The first chapter of this thesis focuses on the development of a general technique in which the stability of a specific protein is regulated by a cell-permeable small molecule. Mutants of E. coli dihydrofolate reductase (ecDHFR) were engineered to have ligand-dependent stability, and when this destabilizing domain is fused to a protein of interest, the instability is conferred to the fused protein resulting in rapid degradation of the entire fusion protein. A small-molecule ligand trimethoprim (TMP) stabilized the destabilizing domain in a rapid, reversible and dose-dependent manner, and protein levels in the absence of TMP were barely detectable. The ability of TMP to cross the blood-brain barrier enabled the tunable regulation of YFP expressed rat striatum. The second chapter of this thesis describes the development of a technique in which a protein of interest is degraded in the presence of a ligand. In this system, we regulated the stability of a receptor protein of an E3 ligase complex using the previously developed destabilizing domains. A DD-fused receptor protein cannot recruit the substrate to the E3 ubiquitin ligase in the absence of ligand. Upon addition of ligand, the receptor protein is stabilized and can successfully promote ubiquitination and degradation of the substrate protein. We used HIV-1 Vif protein, a receptor protein of the Cul5 E3 ligase complex, and its substrate, human APOBEC3G. We were able to induce degradation of GFP fused APOBEC3G upon addition of ligand. Degradation of GFP occurred rapidly, tunably, and reversibly. The advantage of this system over the DD technology is that it does not require continuous administration of the ligand until the desired experimental window and is thus better suited for in vivo applications. By limiting the dosage to only during the knockout window, the cost of dosing is dramatically decreased and side effects from long-term administration of ligand can be minimized. The third and last chapter of this thesis describes an attempt to develop a new approach to induce genome modification at a specific site with high efficiency in mammalian cell lines. While there are several successful nuclease-based gene-targeting approaches that exist today, these technologies require extensive engineering and screening to isolate efficient and specific nucleases that bind to the target sites. Our strategy was to simplify the design of DNA targeting domains by using an oligonucleotide analogue, peptide nucleic acid (PNA). PNAs incorporate DNA bases on peptide backbones and make base-specific contacts with the target DNA site. The PNA domain is coupled to TMP, which then allows recruitment of the nuclease domain fused to ecDHFR. The nuclease domain is made up of a single-chain, pseudohomodimer FokI catalytic domain that non-specifically cleaves the DNA. We could not produce any recombination activity in cell. However, in vivo experiments revealed successful target DNA binding by the PNA, as well as TMP-PNA/ecDHFR-FokI binding.
  • v. 1-2, 1995-1996
    Manfred Zierhut ; translated from the German by Thomas E. Rice.
    Status: Not Checked OutLane Catalog Record
    v. 1. Differential diagnosis -- v. 2. Therapy.
  • 2016 Springer
    Jyotirmay Biswas, Parthopratim Dutta Majumder, editors.
    Chapter 1 Advances in ocular toxoplasmosis -- Chapter 2 Viral anterior uveitis -- Chapter 3 Behçet disease -- Chapter 4 Biologicals in uveitis -- Chapter 5 Corticosteroid in uveitis -- Chapter 6 Glaucoma in uveitis -- Chapter 7 Ocular lesions in AIDS -- Chapter 8 imaging in uveitis -- Chapter 9 Immunosuppressives inuveitis and ocular inflammation -- Chapter 10 Intraocular lymphoma -- Chapter11 Intermediate uveitis -- Chapter 12 Management of inflammatory CNV.-Chapter 13 Ocular parasitic infections -- Chapter 14 Ocular sarcoidosis -- Chapter 15 Intraocular tuberculosis -- Chapter 16 Paediatric uveitis -- Chapter 17 Serpiginous choroiditis -- Chapter 18 White dot syndromes.
  • 2010 ClinicalKey
    Robert B. Nussenblatt, Scott M. Whitcup.
    Uveitis is the comprehensive reference you need for a balanced approach to basic science and clinical application. Robert B. Nussenblatt and Scott M. Whitcup provide a cohesive and integrated discussion of the topic, covering everything from the role of surgery to AIDS to anterior uveitis and more. This new edition even includes full color throughout, 400 photographs and illustrations, and searchable access to the text online at expertconsult.com. Comprehensive yet readable, this resource packs everything you need in patient evaluation and management to achieve optimal results. Covers the medical, pharmacological, and surgical treatment of uveitis to serve as a complete overview of all uveitis related information. Features multiple chapters on diagnostic approach to help you overcome challenges in making accurate diagnoses. Provides additional information on inflammatory eye diseases in chapters on scleritis, masquerade syndromes, and the role of inflammation in other ocular diseases for more comprehensive coverage. Includes illustrated case studies to supplement major clinical points and provide insight into real situations that you can apply in practice. Highlights important information in key points boxes that make it easy to locate crucial points on each topic.
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What is it?

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.

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