Books

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  • Print
    Daniel Lee Chao.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Tim Swanwick.
    ProQuest Ebook Central2014
    Understanding medical education / Tim Swanwick -- Teaching and learning in medical education: how theory can inform practice / David M Kaufman and Karen V. Mann -- Principles of curriculum design / Janet Grant -- Quality in medical education / Alan Bleakley, Julie Browne and Kate Ellis -- Problem-based learning / Mark A Albanese -- Interprofessional education / Della Freeth -- Work-based learning / Clare Morris and David Blaney -- Supervision, mentoring and coaching / John Launer -- Teaching and leading small groups / Peter McCrorie -- Lectures and large groups / Andrew Long and Bridget Lock -- Technology-enhanced learning / Alison Bullock and Peter de Jong -- E-learning / Scott Rice and Jean McKendree -- Simulation in medical education / Jean Ker and Paul Bradley -- Portfolios in personal and professional development / Erik Driessen and Jan van Tartwijk -- Self-regulated learning in medical education / Casey B. White, Larry D.Gruppen and Joseph C. Fantone -- Learning medicine from the humanities / J. Jill Gordon and H. Martyn Evans -- Patient involvement in medical education / John Spencer and Judy McKimm -- How to design a useful test: the principles of assessment / Lambert WT Schuwirth and Cees PM van der Vleuten -- Written assessment / Brian Jolly -- Workplace assessment / John J Norcini -- Structured assessments of clinical competence / Katharine A. M. Boursicot, Trudie E Roberts and William P Burdick -- Standard setting methods in medical education / Andr F. De Champlain -- Formative assessment / Diana F Wood -- Thinking about research: theoretical perspectives, ethics and scholarship / Jan Illing -- Quantitative research methods in medical education / Geoff Norman and Kevin W Eva -- Qualitative research in medical education: methodologies and methods / Lorelei Lingard, Tara J. Kennedy and Stella Ng -- Programme evaluation: improving practice, influencing policy and decision-making / Chris Lovato and David Wall -- Selection into medical education and training / Fiona Patterson , Eammon Ferguson and Alec Knight -- Career progression and support / Caroline Elton and Nicole J. Borges -- Managing remediation / Deborah Cohen, Melody Rhydderch and Ian Cooper -- Dealing with diversity / Anthony Americano and Dinesh Bhugra -- Developing medical educators: a journey, not a destination / Yvonne Steinart -- Educational leadership / Judy McKimm and Tim Swanwick.
  • Digital
    edited by Tim Swanwick.
    ProQuest Ebook Central2010
    Understanding Medical Education originated as a series of monographs in September 2006, the brainchild of Association of Medical Education's then Chief Executive, Frank Smith. The series was designed to meet the needs of all newcomers to medical education. Contributors have included experts from all walks of medical education from across the world. These monographs which have now been collected into a single core textbook, provide a comprehensive guide to the theoretical and academic bases to modern medical education practice--from notes provided by publisher.
  • Digital
    Wendy Levinson, Frederic W. Hafferty, Shiphra Ginsburg, Catherine R. Lucey.
    AccessMedicine2014
    A practical approach to 'professionalism' -- Building professional resiliency -- A brief history of medicine's modern-day professionalism movement -- Professional behaviors and skills needed to deliver patient-centered care -- Integrity and accountability -- Professionalism and a commitment to excellence -- Fair and ethical stewardship of health care resources -- The 'hidden curriculum' and professionalism -- Education -- Evaluating professionalism -- When things go wrong -- Organizational professionalism.
  • Digital
    Robert M. Bray, Laurel L. Hourani, Jason Williams, Marian E. Lane, Mary Ellen Marsden.
    Springer2014
    From the stresses of repeated deployments to the difficulties of re-entry into civilian life, we are just beginning to understand how protracted conflicts, such as those in Iraq and Afghanistan, are affecting service members. Issues such as risky health behaviors and chemical dependence raise productivity concerns as they do with all organizations, but they also have a profound impact on the safety and readiness of troops--and by extension, the military as a whole--in life-or-death situations. Understanding Military Workforce Productivity cuts through the myths and misconceptions about the health and resilience of today's active-duty armed forces. This first-of-its-kind volume presents up-to-date findings across service branches in core health areas including illness and injury, alcohol and drug abuse, tobacco use, obesity, and mental health. The short- and long-term implications discussed relate to the quality of the lives of service members and their families, the quality and preparedness of the military as a workforce, and prevention and intervention efforts.
  • Digital
    Robert M. Wachter.
    AccessMedicine2012
    An introduction to patient safety and medical errors -- The nature and frequency of medical errors and adverse events -- Basic principles of patient safety -- Safety, quality, and value -- Medication errors -- Surgical errors -- Diagnostic errors -- Human factors and errors at the person-machine interface -- Transition and handoff errors -- Teamwork and communication errors -- Healthcare-associated infections -- Other complications of healthcare -- Patient safety in the ambulatory setting -- Information technology -- Reporting systems, root cause analysis, and other methods of understanding safety issues -- Creating a culture of safety -- Workforce issues -- Education and training issues -- The malpractice system -- Accountability -- Accreditation and regulations -- The role of patients -- Organizing a safety program.
  • Digital
    Robert M. Wachter, Kiran Gupta.
    AccessMedicine2018
    The nature and frequency of medical errors and adverse events -- Basic principles of patient safety -- Safety, quality, and value -- Medication errors -- Surgical errors -- Diagnostic errors -- Human factors and errors at the person-machine interface -- Transition and handoff errors -- Teamwork and communication errors -- Healthcare-associated infections -- Other complications of healthcare -- Patient safety in the ambulatory setting -- Information technology -- Reporting systems, root cause analysis, and other methods of understanding safety issues -- Creating a culture of safety -- Workforce issues -- Education and training issues -- The malpractice system -- Accountability -- Accreditation and regulations -- The role of patients -- Organizing a safety program.
  • Digital
    Philippe Courtet, editor.
    Springer2016
    In this book international experts address a range of key current issues relating to suicide. The opening chapters discuss nosology, definitions, clinical determinants, and conceptual models of the suicide process and consider the evidence regarding potential biomarkers of suicide risk based on neuroscientific research. Adopting a neo-Durkheimian perspective, the role of various social factors in the genesis of suicidal behavior is then explored in depth. Practical user-friendly tools that facilitate risk assessment by clinicians are provided, and detailed consideration is given to efficient and innovative strategies for the prevention of suicide and the treatment of suicidal behavior, such as psychotherapy, psychopharmacological approaches, and effective organization of care, including surveillance and the use of online tools. The final part of the book focuses on the need for and development of a personalized approach within the field of suicide prevention. Understanding Suicide will be of interest to psychiatrists, psychologists, mental health professionals, general practitioners, researchers in suicidology, and students.
  • Digital
    Gordon Mosser, James W. Begun.
    AccessMedicine2014
    A complete introductory guide to the principles and clinical application of team-based medicine, Understanding Team-Based Healthcare emphasizes the essential competencies necessary to implement team-based medicine in a complex hospital or primary care setting. Unlike similar books on the subject which are theoretical or policy-oriented, this text offers practical, real-world coverage, and is valuable for healthcare professionals seeking a thorough explanation of teamwork and for trainers working in hospitals or primary care settings. Features: could also be used as a textbook; mini-cases throughout the text help readers appreciate real-world application of principles; written for a level suited for the non-specialist.
  • Digital
    [edited by] Karen S. Rheuban, Elizabeth A. Krupinski.
    AccessMedicine2018
    History of telehealth / Thomas S. Nesbitt, Jana Katz-Bell -- Workforce, telehealth definitions, and models / Karen S. Rheuban, Scott Shipman -- Rural health / Katharine Hsu Wibberly -- Integration of applications supporting seamless delivery of telehealth solutions / Elizabeth A. Krupinski -- Telestroke / Andrew M. Southerland, Nina J. Solenski, Lee H. Schwamm -- High-risk obstetrics and telehealth / Curtis Lowery -- Teleophthalmology : future technologies for screening eye exams / Alice Yang Zhang, Christine Y. Yoon, Ingrid E. Zimmer-Galler -- Adult emergency and critical care telehealth / H. Neal Reynolds, Marc T. Zubrow, Richard Alcorta, Neal Sikka -- Teledermatology / Hon Pak, Ivy A. Lee, John D. Whited -- Telepsychiatry / Maryann Waugh, Peter Yellowlees, Rachel Dixon, Jay H. Shore -- Remote patient monitoring and care coordination / Amy L. Tucker -- Rehabilitation / Trevor G. Russell, Deborah G. Theodoros -- Pediatric emergency and critical care telemedicine / Alison L. Curfman, James P. Marcin -- Child telepsychiatry / Peter Yellowlees, Maryann Waugh, Jay H. Shore -- School and childcare center telemedicine / Neil E. Herendeen -- Telemedicine in pediatric cardiology / Craig Sable -- Telehealth in the care of children with special health care needs and medical complexity / Kathleen A. Webster -- The dawn of direct-to-consumer telemedicine / Ateev Mehrotra, Lori Uscher-Pines, Michelle S. Lee -- Telemedicine in the department of defense : a journey from the battlefield to stateside care / Ronald Poropatich, Charles Lappan, Gary Gilbert -- International humanitarian outreach and telehealth / Dale C. Alverson -- Patients, their physicians, and telemedicine / Jack Resneck, Jr., Sylvia J. Trujillo, Kristin Schleiter -- The state policy framework of telehealth / Latoya S. Thomas -- Medicare coverage and reimbursement policies / Gary Capistrant -- Legal and regulatory issues / Nathaniel M. Lacktman.
  • Digital
    Trisha Stan.
    From their earliest histopathological descriptions, neurodegenerative disorders have been known to involve neuroinflammation. Yet the exact nature of the changes in inflammation, as well as the role of neuroinflammation in the pathogenesis of the disease, are not well understood. In this dissertation, I attempt to uncover the nature of the changes in the systemic immune system in neurodegeneration and the role that these changes play in disease progression. The first study presented here (Chapter 2) presents an investigation of the changes in the plasma cytokines and peripheral immune cells in Frontotemporal Dementia. Frontotemporal Dementia is the leading cause of early-onset neurodegenerative disease and is known to be caused by several mutations, including one that results in haploinsufficiency of progranulin, a gene known to attenuate inflammation. However, Frontotemporal Dementia is often sporadic, with no known genetic or environmental cause, and the underlying changes that cause this very specific, localized neurodegeneration has been unclear. In this study, we use an unbiased protein profiling platform, the antibody microarray, developed in our lab, to assay the changes in plasma protein levels in progranulin-mutation Frontotemporal Dementia and sporadic Frontotemporal Dementia. We found that there was an increase in pro-inflammatory cytokines similar to changes in cytokines observed in autoimmune disease and suggestive of changes in cellular immune phenotype. Therefore, we used a new flow cytometry technology, CyTOF by Time of Flight mass spectrometry (CyTOF), to profile immune cells in FTD patients in an unbiased manner. We found changes in CD8 T cells and Natural Killer cells similar to changes observed in autoimmune disorders. Along with colleagues at UCSF, we then conducted a retrospective study to determine if FTD patients have a higher comorbidity of autoimmune disease than the general population, and we found this to be the case. We found similar changes in inflammatory proteins and immune cells in the mouse model of Frontotemporal Dementia (GRN -/-). The next series of experiments (Chapter 3) sought to determine how the changes in the systemic protein levels in the plasma FTD patients affected the changes in the central nervous system (CNS) associated with the neurodegenerative disorders and with the changes in immune cell populations. To this end, we used two methods of introducing FTD-disease plasma to WT or GRN +/- mice: parabiosis and human plasma transfer. While we observed no changes in the strongest phenotype of the mouse model, microgliosis, in the parabiosis experiment, we observed intriguing behavior changes in GRN +/- animals treated with plasma from human FTD patients. For the next set of experiments to determine the relationship between the cytokine changes in FTD patients and the immune cell subset changes, we developed a new culture system in which we cultured whole blood with plasma-infused media, enabling us to use cells from a single donor to assay the effects of exposure of aged or FTD-patient plasma. In the final series of experiments, we sought to solidify the understanding of the changes in the systemic immune system in Alzheimer's Disease with a thorough immunophenotyping study. For four years, we collected and cryopreserved peripherial blood mononuclear cells from Alzheimer's Disease patients, resulting in a collection of over 100 samples from patients with mild to sever Alzheimer's Disease, patients with Mild Cognitive Impairment, a precursor to Alzheimer's Disease, and age-matched, cognitively healthy individuals. We developed a new CyTOF platform panel to measure the ability of cells to respond to cytokine treatment as well as the traditional immunophenotyping. We found indications that cells from Alzheimer's Disease patients are less responsive to cytokine stimuli. Collectively, this work highlights the importance of the changes in the systemic immune system in neurodegenerative disorders. It provides new insight into possible mechanisms of disease pathology and potential new avenues for future therapeutic targets.
  • Digital
    Laura R. McCabe, Narayanan Parameswaran, editors.
    Springer2017
    "This is the first book compiling current research on the gut-bone signaling axis and its implications in the pathophysiology of GI and bone diseases. Rather than focusing on a single mechanism, this book provides the reader with a broad view on gut-bone signaling and the most up-to-date information in this rapidly growing area. The volume is also unique in that it looks at what is known about GI diseases affecting bone and then examines the role of the microbiome and its modulation by pre and probiotics to treat bone disease, placing this topic within the context of gut-bone signaling pathways. Understanding the Gut-Bone Signaling Axis will thus provide an understanding of how various therapies could be applied to this area"--Publisher's description.
  • Digital
    Gerald W. Tannock.
    Wiley2017
    "This book discusses the community of microbial species (the microbiota, microbiome), which inhabits the large bowel of humans. Written from the perspective of an academic who has been familiar with the topic for 40 years, it provides a long-term perspective of knowledge about this high profile and fast-moving topic. Building on general ecological principles, the book aims to help the reader to understand how the microbiota is formed, how it works, and what the consequences are to humans."--Provided by publisher.
  • Digital
    Sean Frederick Scanlan.
    The overall goal of this dissertation was to address the question of the relationship between anterior cruciate ligament (ACL) graft function, changes in walking mechanics, and the morphology of the articular cartilage in the ACL reconstructed knee as a step towards filling critical gaps in the available knowledge of the association between ACL injury and premature osteoarthritis of the knee. ACL injury often leads to premature osteoarthritis of the knee even when the ACL is reconstructed and alterations in knee mechanics during walking have been identified as a potential mechanism of cartilage degeneration in the ACL deficient knee. This thesis provides the results of experimental studies using magnetic resonance (MR) imaging and gait analysis to understand the effect of ACL reconstruction on the mechanics of walking and articular cartilage morphology in the context of a potential mechanism for the initiation of osteoarthritis. These results provide a basis for improving the treatment and long-term prognosis of the ACL injured knee. Gait analysis of subjects after ACL reconstruction showed that during the stance phase of walking, their ACL reconstructed knee had significantly more external tibial rotation when compared to their contralateral knee. This kinematic alteration likely causes changes in normal cartilage contact mechanics and could contribute to the eventual degeneration of the articular cartilage. Analysis of ACL graft placement in this population revealed a potential mechanism for the observed alteration in ambulatory mechanics in the ACL reconstructed knee. Variations in graft placement were correlated with the magnitude of the peak external knee flexion moment (balanced by a net quadriceps moment) and the tibiofemoral rotational position of the reconstructed knee during walking. In both cases, non-anatomic graft placement resulted in greater deviations in the ambulatory mechanics of the ACL reconstructed knee. Since these results indicated graft placement plays a critical role in the restoration of normal ambulatory mechanics, MR imaging was utilized to develop a method to determine the three-dimensional location of native tibial and femoral ACL insertions to guide and evaluate anatomic ACL graft placement. Analysis of healthy and ACL reconstructed subjects revealed the presence of side-to-side symmetry in location of ACL insertions in healthy subjects but not after transtibial ACL reconstruction, indicating that conventional transtibial reconstruction frequently places the graft outside the center of the anatomical ACL footprint. Further examination of the effects of non-anatomic ACL graft placement revealed the unintended consequences of vertical sagittal orientation of the ACL graft. These results demonstrated that although vertical sagittal graft orientation was associated with less occurrence of an active knee extension deficit during walking (as intended), it was also associated with an increased anterior tibial neutral position in the ACL reconstructed knees. Finally, in order to investigate the mechanism of the proposed kinematic pathway to osteoarthritis after ACL reconstruction, the individual-specific femoral cartilage thickness distribution was related to knee flexion during walking in the reconstructed and healthy contralateral knees. The results of this study showed that although a relationship existed in both the reconstructed and contralateral knees, a shift in knee flexion at heel-strike without an adaptation in cartilage thickness distribution caused an alteration in the relationship in the ACL reconstructed knees. Thus failure of the ACL reconstruction to restore normal walking mechanics could contribute the breakdown of articular cartilage in the ACL reconstructed knee. The results of these studies provide a better understanding of the influence of ACL reconstruction on the subsequent changes in the mechanics of the ACL reconstructed knee. These findings present insights into the complex relationship between variations in ACL graft placement, changes in walking mechanics, and the distribution of cartilage thickness in the context of a potential kinematic mechanism for the development of premature osteoarthritis after ACL injury and reconstruction. Taken together, these results provide a basis for improving the standard of care for the ACL injured knee.
  • Digital
    Jia-Ren Lin.
    Post-replication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18-mediated translesion synthesis (TLS) are two forms of PRR. Two Rad5-related proteins, SHPRH and HLTF, have been identified in mammalian cells, but their specific roles in PRR are unclear. Here, we show that HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV and MMS, respectively. Following UV, HLTF enhances PCNA monoubiquitination and recruitment of TLS polymerase eta, while also inhibiting SHPRH function. In contrast, MMS promotes the degradation of HLTF and the interactions of SHPRH with Rad18 and polymerase kappa. Our data not only suggest that cells differentially utilize HLTF and SHPRH for different forms of DNA damage, but also, surprisingly, that HLTF and SHPRH may coordinate the two main branches of PRR to choose the proper bypass mechanism for minimizing mutagenesis. Though the degradation of HLTF is required for the SHPRH-Rad18 interaction in MMS-damaged cells, knockdown of HLTF is not sufficient to induce SHPRH-Rad18 binding in undamaged cells. Thus, an unidentified factor, in addition to HLTF degradation, is required to fully activate SHPRH and Rad18 upon MMS damage. We have noticed that Rad18 is deubiquitinated after MMS treatment, and that this de-ubiquitination is correlated with the degree of Rad18-SHPRH interaction. Moreover, we show that promoting the ubiquitination of Rad18 has an inverse effect on the interaction with SHPRH both in vitro and in cells. Surprisingly, though, the ubiquitinated Rad18 shows a stronger self-interaction than the wild-type Rad18, opposite from the SHPRH binding results. As the zinc-finger motif of Rad18 has been previously shown to bind ubiquitin, this may be a logical mechanism to control the switch between Rad18 dimerization and its interaction with other proteins. Interestingly, ubiquitinated Rad18 appears to be inactive, not only from loss of its ability to interact with SHPRH, but also through the inability to form damage foci and suppress MMS-induced mutagenesis. Altogether, our data reveal a unique regulation of Rad18 through self-ubiquitination and dimerization. In summary, our studies have revealed a number of new mechanistic insights into the post-replication repair pathways in human cells, including the interesting conclusion that protein degradation, deubiquitination, and other key cell processes may be controlled in a DNA damage-specific manner.
  • Digital
    Ruth Sommese.
    Heart disease is one of the leading causes of morbidity and mortality in the developed world. As such, significant amount of resources and energy are funneled into developing treatments and therapeutics. While genetically caused cardiovascular diseases manifest at the tissue level, the fundamental mechanism that triggers the secondary effects and tissue remodeling generally occurs at the protein level. It is therefore critical to understand the molecular changes on the basic biochemical and biophysical level and connect these to the cellular and developmental disease processes. One such cardiovascular disorder is hypertrophic cardiomyopathy or HCM, which has been estimated to affect approximately 1 in 500 individuals. It disproportionately affects young adults and is the leading cause of sudden cardiac death. Since the first case of genetically linked HCM was identified in the early 1990s, a significant amount of work has been done to understand the molecular mechanism of the disease. Mutations have been identified in the proteins comprising the contractile apparatus of the muscle, the sarcomere. One such protein is [beta]-cardiac myosin, which has been recognized as a significant culprit of genetically linked HCM (~30-50%). Many studies have been performed to understand how single point mutations can alter the enzymatic and mechanical properties of this motor protein, but there is no clear consensus about the molecular mechanism. This has been due mainly to the lack of available human [beta]-cardiac myosin and the use of non-human and non-[beta]-cardiac myosin. Non-human and non-[beta]-cardiac myosin from common animal models differ by >30 residues, and as clearly evident from the disease and from previous studies on myosin, a single amino acids mutation can significantly alter and disrupt myosin function. During my thesis work, I have performed the first biochemical and biophysical work in the field looking at cardiomyopathy mutations using human [beta]-cardiac myosin. I have shown that HCM-causing [beta]-cardiac myosin mutations result in a gain of function, increasing the power or work output of the myosin. I have also examined HCM-causing mutations in troponin T, a component of the thin filament regulatory unit, using human [beta]-cardiac myosin. In the muscle, the interaction of myosin and actin is regulated by calcium through the thin filament proteins, namely the troponin complex and tropomyosin. HCM-causing mutations in troponin T increase calcium sensitivity or the number of force-producing heads that can interact with actin, thereby also increasing force or power output in the muscle. My work not only sheds light on fundamental properties of thick and thin filament function in the human sarcomere and presents the first studies of HCM-causing mutants in a human background, it also establishes a new approach to the problem of cardiomyopathy that will be critical in truly understanding and targeting the disease.
  • Digital
    Payal Joglekar.
    Intestinal IgA is one of the major host factors that shapes our gut microbiota composition and functionality. However, the actual mechanisms involved in the IgA-commensal interaction remain understudied. Our current work uses a model gut commensal, Bacteroides thetaiotaomicron VPI-5482 (Bt), in a gnotobiotic mouse model system to identify Bt antigens that prime a specific gut IgA response. Our study shows that the gut IgA targets a diverse set of bacterial proteins involved in a variety of functions that are thought to be important for bacterial colonization, survival and competition in the host intestine. Our IgA screen identified Bt proteins involved in utilization of dietary fructans that allow Bt to thrive in the gut lumen, when fructans are present in the host diet. Specifically, we identified the outer membrane machinery (OMM) involved in degradation and uptake of β2-6 fructans to be an active target of specific IgA. Biochemical and genetic analysis of this operon in closely related Bacteroides thetaiotaomicron strains demonstrated that the genes encoding the OMM determines fructan specificity, and thus the type of fructan that is utilized by a given organism. Further, comparative genomic analysis of the fructan utilization loci in closely related Bacteroides spp., revealed that the OMM is variably conserved. Using gene transfer experiments we were able to establish that the OMM acts as functional unit that can be transferred among closely related Bacteroides, which allows gain of a new specificity by the recipient organism. Our study further demonstrated that the OMM determines bacterial competitiveness in the gut in presence of specific fructans. Inquiry into the role of IgA in targeting this OMM demonstrated that specific IgA causes reduced expression of the fructan operon in presence of dietary fructans. We propose that this mechanism should allow the host to prevent bacterial overgrowth in presence of specific fructans. Our study thus highlights a novel mechanism by which the host regulates the growth of gut commensals, and could serve as an important pathway to control the gut microbial composition in the wake of dietary disturbances. Further our study also demonstrated that the natural, polyreactive IgA secreted in the mouse gut showed weak binding to Bt antigens. Analysis of the fructan operon expression in presence of this natural IgA indicated that the operon was upregulated in the early stages of bacterial colonization, even in absence of specific fructans. We propose that the natural IgA acts as a cue for Bt to non-specifically upregulate its nutrient utilization pathways in order to compete in the high bacterial density environment that it normally faces in a conventional host gut. Our current works sheds new light on the mechanism by which the gut IgA controls bacterial functionality in the gut lumen in order to maintain gut homeostasis.
  • Digital
    Danielle Lurisa Leiske.
    The tear film is the thin layer of fluid that covers the surface of the eye. While the functions of the tear film are numerous, the primary role is to protect the corneal surface. When an individual has dry eye disease the tear film breaks up and exposes the corneal epithelial cells, which leads to ocular irritation. The primary components of the outermost layer of the tear film are meibomian lipids, a mixture of long chain nonpolar lipids. Although this lipid layer is thought to play an important role in tear film stability, little is known about the structure and viscoelasticity of meibum, or how these properties relate to tear film stability in dry eye disease. The primary focus of this work was to understand how meibum behaves at an air-water interface to mimic the in vivo conditions of the tear film lipid layer. At room temperature meibum was found to form a predominantly elastic interfacial film, although the film became more fluid as it was heated to body temperature. Interfacial x-ray scattering at room temperature revealed ordered lattices and multilayers at high levels of compression that contributed to high elasticity. In bulk samples, small angle x-ray scattering identified two populations of lipid lamellar phases with unique melt behavior. Meibum collected from patients with meibomian gland dysfunction, a form of dry eye disease, contained the same crystalline phases; however, the prevalence of those phases was reduced indicating a quantifiable change in lipid composition. To ascertain whether meibum viscoelastic properties are relevant to tear film performance, the effects of surface elasticity on an advancing droplet were studied. While droplets covered with a Newtonian monolayer followed classical hydrodynamics, meibum and other insoluble surfactants with surface shear elasticity induced periodic stick-release of the contact line at low advancing velocities and non-ideal behavior at higher velocities. Finally, to explore how a water soluble surfactant may be used to repair a compromised lipid layer, the interactions between a poly(ethylene oxide)-poly(butylene oxide) block copolymer (EOBO) and a model phospholipid monolayer were studied. The lipids and EOBO remained phase separated at the interface, yet EOBO was able to restore the native lattice spacing and mechanical properties of the lipid monolayer, which could make it a valuable tool for a number of biological applications. Meibomian lipids are a complex natural extract with a number of remarkable properties. Although the lipids present in meibum are diverse, meibum can form an elastic interfacial film with ordered phases in bulk material or at an interface. We have shown a link between meibum structure and elasticity, which both depend on temperature. Major composition changes that occur with disease could alter meibum melt temperature and viscoelasticity, which will ultimately modulate the ability of meibum to stabilize the tear film.
  • Print
    Deborah Lynn Burkhart.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Kathleen Sitzman, PhD, RN, CNE, ANEF, Professor, Undergraduate-Senior, East Carolina University, Greenville, North Carolina, Lisa Wright Eichelberger, PhD, RN, Dean and Professor, College of Health, Clayton State University, Atlanta, Georgia.
    Ovid2017
    Understanding the Work of Nursing Theorists, Third Edition presents the difficult concepts of nursing theory through the use of art. While most theory texts are complex and more detailed than what is needed for students at an introductory level of theory, this text offers a different approach to teaching and learning nursing theory. Definitions and basic concepts are presented along with a brief overview of a selection of common nursing theories. The author encourages creativity through art in an effort to engage students and make them more active learners. The Third Edition includes new chapters on the theories of Patricia Benner, Imogene King, and Rosemarie Parse as well as a chapter on the process of theory development by Jean Watson. The Application to Practice sections are new and will appear as research article in each theorist chapter. -- Provided by publisher.
  • Digital
    editors, Christopher Moriates, Vineet Arora, Neel Shah.
    AccessMedicine2015
    The current state of healthcare costs and waste in the United States -- Medical coverage in the United States -- The challenges of understanding healthcare pricing -- Defining value : connecting quality and safety to the costs of care -- A changing landscape : cost consciousness and value in healthcare delivery -- Ethics of cost conscious care -- The importance of zip codes and genetic codes : variation in resource utilization -- Stents, robots, and the role of technology diffusion -- Primary care shortage crisis : lost opportunities to deliver value / David Margolius and Andrew Morris-Singer -- Barriers to providing high-value care / Daisy Smith and Steven Weinberger -- Building a pipeline for change : teaching about cost awareness and evidence-based medicine -- The role of patients : shared decision making, e-patients, and consumer directed healthcare -- High-value medication prescribing -- Screening and prevention : balancing benefits with harms and costs -- Shifting incentives : moving reimbursement from volume to value -- Implementing value-based initiatives : a new challenge for clinicians and healthcare systems.
  • Digital
    Li Zhaoping.
    OSO2014
    Approach and scope -- A very brief introduction of what is known about vision experimentality -- The efficient coding principle -- V1 and information coding -- The V1 hypothesis : creating a bottom-up saliency map for preattentive selection and segmentation -- Visual recognition as decoding -- Epilogue.
  • Digital
    edited by Simon S. Cross ; illustrations and chapter icons by Robert Britton.
    ClinicalKey2013
    What is pathology? -- What is disease? -- What causes disease? -- Disorders of growth, differentiation and morphogenesis -- Responses to cellular injury -- Disorders of metabolism and homeostasis -- Ischaemia, infarction and shock -- Immunology and immunopathology -- Inflammation -- Carcinogenesis and neoplasia -- Ageing and death -- How do pathologists help patient care? -- Cardiovascular system -- Respiratory tract -- Liver, biliary system and pancreas -- Endocrine system -- Breast -- Female genital tract -- Urinary and male genital tracts -- Kidney diseases -- Lymph nodes and extranodal lymphoid tissue, spleen and thymus -- Blood and bone marrow -- Skin -- Osteoarticular and connective tissues -- Central and peripheral nervous systems.
  • Digital
    Glenn L. Schattman, Sandro C. Esteves, Ashok Agarwal, editors.
    Springer2015
    Part I: Definitions and Epidemiology -- Definitions and Relevance of Unexplained Infertility in Reproductive Medicine -- Definitions and Epidemiology of Unexplained Male Infertility -- Controversies Surrounding the 2010 World Health Organization Cutoff Values for Human Semen Characteristics and Its Impact on Unexplained Infertility -- Definitions and Epidemiology of Unexplained Female Infertility -- Part II: Pathophysiology: Male -- Sperm Biology from Production to Ejaculation -- Idiopathic Infertility: Survival and Function of Sperm in the Female Reproductive Tract -- Potential Male Etiologies of Unexplained Infertility -- Genetic Basis of Unexplained Male Infertility -- Role of the Immune System in Unexplained Male Infertility -- Oxidative Stress in Unexplained Male Infertility -- Role and Significance of Sperm Function in Men with Unexplained Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility -- Part III: Pathophysiology: Female -- Potential Female Etiologies of Unexplained Infertility -- Oxidative Stress in Unexplained Female Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Female Infertility -- Cervical Hostility and Vaginal pH in Females with Unexplained Infertility -- Role of Endometrial Receptivity in Unexplained Infertility -- Fallopian Tube Dysfunction in Unexplained Infertility -- Subtle Endometriosis and Unexplained Infertility -- Part IV: Evaluation -- Evaluation of Women with Unexplained Infertility -- Evaluation of Men with Unexplained Infertility -- Part V: Expectant, Medical and Surgical Treatment -- The Role of Expectant Management for Couples with Unexplained Infertility -- Treatment and Prognosis of Immunological Factors in Unexplained Male Infertility -- Medication Strategies for the Male with Unexplained Infertility -- Clomiphene Citrate for Women with Unexplained Infertility -- Aromatase Inhibitors in the Treatment of Unexplained Female Infertility -- Gonadotropins for Women with Unexplained Infertility -- Part VI: Assisted Reproductive Techniques and Future Perspectives -- Gonadotropin in Assisted Reproduction: An Evolution Perspective -- Intrauterine Insemination in Unexplained Female Infertility -- Role of In Vitro Fertilization in Unexplained Female Infertility -- Role of Assisted Reproduction Techniques in the Management of Unexplained Male Infertility -- Future Perspectives in the Diagnosis and Management of Unexplained Male Infertility.
  • Digital/Print
    edited by P. Michael Conn.
    Digital : ScienceDirectpt. A
    Digital : ScienceDirectpt. B
    Digital : ScienceDirectpt. C
  • Digital
    edited by Michael T. Hirschmann, Roland Becker.
    Springer2015
    Owing to improved understanding of biomechanics and tribology and advances in implant design and treatment technique, total knee arthroplasty (TKA) is considered a very successful treatment for osteoarthritic knees. Nevertheless, a significant minority of patients are unhappy with the outcome, complaining of pain, instability, swelling, or reduced range of motion. This book addresses the need for improved diagnostic and treatment guidelines for this challenging group of patients. The book opens by discussing the basics of TKA and the various causes of failure and pain. Diagnostic aspects are considered in detail, with attention to advances in clinical investigation, laboratory analysis, and, in particular, imaging techniques. Furthermore, state of the art diagnostic algorithms are presented that will assist in identifying the source of the problem in individual cases. Specific pathology-related treatment options, including conservative approaches and salvage and revision TKA strategies, are then explained, with identification of the pitfalls and key points of each treatment. Future perspectives are briefly considered, and a series of cases are presented that cover clinical scenarios frequently encountered in daily clinical practice. The evidence-based, clinically focused guidance provided in this book, written by internationally renowned experts, will assist surgeons in ensuring that patients with an unsatisfactory result of TKA receive the most effective management. The book will also be helpful for general practitioners, physiotherapists, industry technicians, and engineers.
  • Digital
    James Rumbaugh, Ivar Jacobson, Grady Booch.
    ProQuest Safari2005
  • Digital/Print
    Digital2004
    Print1994-
    Covers guidelines for the format of manuscripts submitted to biomedical journals. In addition, discusses retraction of research findings, order of authorship, definition of a peer-reviewed journal, and conflict of interest. Each statement was initially published in a scientific journal and citations to the original publications are included.
  • Digital/Print
    Digital : CDC/NCI2002
    Print2002
  • Digital
    edited by Shahid Rahman, Tony Street, Hassan Tahiri.
    Springer2008
  • Print
    Wendy Chisholm and Matt May.
  • Digital
    by Hanns Hippius, Hans-Jürgen Möller, Norbet Müller, Gabriele Neundörfer-Kohl.
    Springer2008
    Early Psychiatric Institutions in Munich -- Psychiatric Care in Bavaria in the 19th Century -- The Chair for Psychiatry at the Medical Faculty of the University of Munich -- Bernhard von Gudden, Doctor and Founder of Modern Neuromorphology -- Planning and Construction of the Royal Psychiatric University Hospital in the Nussbaumstrasse -- The Opening of the Psychiatric Hospital in 1904 by Emil Kraepelin -- The Munich Hospital Managed by Emil Kraepelin -- The Idea and Planning of the German Psychiatric Research Institute -- Oswald Bumke and his Munich Workgroup -- The Post War Period and Beginning of the Hospital's Reconstruction under Georg Stertz -- Kurt Kolle and Plans for a New Hospital Building in Grosshadern -- Division of the "Hospital for Nervous Diseases" into a Psychiatric Hospital in the Inner City and a Neurological Hospital in Grosshadern -- The Psychiatric Hospital since 1994 -- The Psychiatric Hospital 1971-1994 -- The Re-Opening of the Historical Old Building -- Scientific publications since 2000.
  • Digital
    by Hanns Hippius ... [et al.].
    Springer2008
  • Digital
    Paola Bergallo.
    Demands for the protection of social rights, and health rights in particular, have become a distinctive feature of judicialization in Latin American countries, including Argentina. Although a growing number of studies have begun to document the new relationship between the courts and health rights generated after almost two decades of litigation, little is yet empirically known about the versatile struggles undertaken in domestic courts and their consequences beyond the judgments. More specifically, given the scarcity of domestic empirical explorations, much remains to be discovered about legal mobilization experiences and courts' roles in the adjudication of conflicts regarding the intersection of health policies and rights. This dissertation takes a step toward filling that gap by exploring a set of conceptual, theoretical, and methodological questions that are critical to advancing current debates on health and the role of courts in bringing justice and expanding the rule of law in Argentina. With that aim in mind, this dissertation proceeds in two stages. First, it offers a basic assessment of the context and magnitude of the judicialization of health in the country, relying on multiple secondary sources and descriptive statistics obtained from databases of court decisions and dockets generated for this dissertation. Second, to complement the broader picture, the project proposes a qualitative study of strands of health rights litigation, offering a process-based observation of diverse patterns of judicialization while helping identify and compare the broader impacts of courts' roles in adjudicating health rights demands. Through these narrative studies, this dissertation tells the story of how once-dormant health rights clauses have come to life through the work of litigants, judges, and policy makers. It also shows how, in the process of unleashing health rights, courts have played contradictory roles throughout the nonlinear trajectories of different patterns of judicialization that can be located along a spectrum in which an atomistic and routinized style of judicialization is at one extreme, a bureaucratizing form of judicialization is in the middle, and a cooperative style of judicialization is at the other extreme. Ultimately, throughout these rich and variegated experiences of judicialization, courts' adjudication of right-to-health claims has sometimes reinforced ineffective or unequal arrangements, while at other times exhibiting potentially transformative capacities.
  • Digital
    J. David Hawkins, Jeffrey M. Jenson, Richard Catalano, Mark W. Fraser, Gilbert J. Botvin, Valerie Shapiro, C. Hendricks Brown, William Beardslee, David Brent, Laurel K. Leslie, Mary Jane Rotheram-Borus, Pat Shea, Andy Shih, Elizabeth Anthony, Kevin P. Haggerty, Kimberly Bender, Deborah Gorman-Smith, Erin Casey, and Susan Stone.
    Every day across America, behavioral health problems in childhood and adolescence, from anxiety to violence, take a heavy toll on millions of lives. For decades the approach to these problems has been to treat them only after they've been identified--at a high and ongoing cost to young people, families, entire communities, and our nation. Now we have a 30-year body of research and more than 50 programs showing that behavioral health problems can be prevented. This critical mass of prevention science is converging with growing interest in prevention across health care, education, child psychiatry, child welfare, and juvenile justice. Together, we stand at the threshold of a new age of prevention. The challenge now is to mobilize across disciplines and communities to unleash the power of prevention on a nationwide scale. Proposes a grand challenge that will advance the policies, programs, funding, and workforce preparation needed to promote behavioral health and prevent behavioral health problems among all young people--including those at greatest disadvantage or risk, from birth through age 24. Within a decade, we can reduce the incidence and prevalence of behavioral health problems in this population by 20 percent from current levels through widespread policies and programs that will serve millions and save billions. Prevention is the best investment we can make, and the time to make it is now.
  • Print
    Georg Northoff.
    v. 1. Coding -- v. 2. Consciousness.
  • Digital
    edited by Loredano Pollegioni, Stefano Servi.
    Springer Protocols2012
    Preparation of unnatural amino acids with ammonia-lyases and 2,3-aminomutases / László Poppe [and others] -- Multistep enzyme catalyzed reactions for unnatural amino acids / Paola D'Arrigo and Davide Tessaro -- Enzymatic production of enantiopure amino acids from mono-substituted hydantoin substrates / Gwynneth F. Matcher, Rosemary A. Dorrington, and Stephanie G. Burton -- Preparation of glutamate analogues by enzymatic transamination / Thierry Gefflaut, Zeinab Assaf, and Martine Sancelme -- Carbon-carbon bond-formng enzymes for the synthesis of non-natural amino acids / Pere Clapés, Jesús Joglar, and Mariana Gutiérrez -- Engineering cyclic amidases for non-natural amino acid synthesis / Francisco Javier Las Heras-Vázquez [and others] -- NMR analysis of unnatural amino acids in natural antibiotics / Franca Castiglione -- Site-specific incorporation of unnatural amino acids as probes for protein conformational changes / Jennifer C. Peeler and Ryan A. Mehl -- Application of unnatural amino acids to the de novo design of selective antibiotic peptides / Rickey P. Hicks and Amanda L. Russell -- Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides / Alessandro Tossi [and others] -- Experimental methods for scanning unnatural amino acid mutagenesis / Jia Liu and T. Ashton Cropp -- Genetic incorporation of unnatural amino acids into proteins in yeast / Qian Wang and Lei Wang -- Site-specific incorporation of unnatural amino acids into proteins in mammalian cells / Nobumasa Hino, Kensaku Sakamoto, and Shigeyuki Yokoyama -- Incorporation of unnatural non-[alpha]-amino acids into the N-terminus of proteins in a cell-free translation system / Takahiro Hohsaka -- Site-specific modification of proteins by the Staudinger-phosphite reaction / Paul Majkut [and others] -- HPLC methods for determination of D-aspartate and N-methyl-D-aspartate / George H. Fisher and Mara Tsesarskaia -- Estimation of chronological age from the racemization rate of L- and D-aspartic acid : how to completely separate enantiomers from dentin / Toshiharu Yamamoto and Susumu Ohtani -- Enzymatic detection of D-amino acids / Gianluca Molla [and others] -- An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures / Inna Radzishevsky and Herman Wolosker -- Electrophysiological analysis of the modulation of NMDA-receptors function by D-serine and glycine in the central nervous system / Fabrice Turpin, Glenn Dallérac, and Jean-Pierre Mothet -- Biosensors for D-amino acid detection / Silvia Sacchi [and others] -- Analysis of D-[beta]-aspartyl isomers at specific sites in proteins / Noriko Fujii and Horihiko Fujii -- Nutritional value of D-amino acids, D-peptides, and amino acid derivatives in mice / Mendel Friedman and Carol E. Levin -- Preparation and assay of recombinant serine racemase / Florian Baumgart, Clara Aicart-Ramos, and Ignacio Rodriguez-Crespo -- Assay of amino acid racemases / Masumi Katane, Masae Sekine, and Hiroshi Homma -- Assays of D-amino acid oxidases / Gabriella Tedeschi, Loredano Pollegioni, and Armando Negri -- Enzymes acting on D-amino acid containing peptides / Yasuhisa Asano.
  • Print
    Philip Lieberman.
    "The Unpredictable Species argues that the human brain evolved in a way that enhances our cognitive flexibility and capacity for innovation and imitation. In doing so, the book challenges the central claim of evolutionary psychology that we are locked into predictable patterns of behavior that were fixed by genes, and refutes the claim that language is innate. Philip Lieberman builds his case with evidence from neuroscience, genetics, and physical anthropology, showing how our basal ganglia--structures deep within the brain whose origins predate the dinosaurs--came to play a key role in human creativity. He demonstrates how the transfer of information in these structures was enhanced by genetic mutation and evolution, giving rise to supercharged neural circuits linking activity in different parts of the brain. Human invention, expressed in different epochs and locales in the form of stone tools, digital computers, new art forms, complex civilizations--even the latest fashions--stems from these supercharged circuits." -- [Publisher-supplied data]
  • Digital
    Kimberly R. Kukurba.
    Understanding the relationship between genotype and phenotype remains one of the greatest challenges in genetics and medicine today. Recently, a wealth of new genomic and functional data has enabled researchers to catalog human genetic variation, characterize their effects on phenotypic variation, and test hypotheses to uncover their underlying mechanisms. Despite these achievements, basic questions about genetic variants remain unanswered, including their full distribution of effects on heritability, their molecular mechanisms of action, and their interaction with environmental variables. Resolving these questions will improve our resolution of the genetic architecture of phenotypic traits and uncover the molecular basis of human disease. This thesis begins to address these questions by dissecting the role of genetic variants on regulatory variation across tissues and individuals. First, Chapter 1 provides a broad introduction to key biological and technological concepts that form the basis of the work presented in this dissertation. Then, Chapter 2 offers a detailed discussion of the experimental and analytical methods utilized to interrogate regulatory variation. Next, Chapter 3 assesses transcriptomic variation across ten tissues of the human body, with a particular focus on patterns of allele-specific expression for deleterious variation. Lastly, Chapter 4 explores differences in regulatory variation between the sexes with a focus on contributions from the X chromosome and potential mechanisms. Together, these chapters provide insight into the impact and mechanistic basis of regulatory variation across tissues and across the sexes.
  • Digital
    Alexis Jane Battle.
    Recent technological advances have allowed us to collect genomic data on an unprecedented scale, with the promise of revealing genetic variants, genes, and pathways disrupted in clinically relevant human traits. However, identifying functional variants and ultimately unraveling the genetics of complex disease from such data have presented significant challenges. With millions of genetic factors to consider, spurious associations and lack of statistical power are major hurdles. Further, we cannot easily assess functional roles even for known trait-associated variants, particularly for those that lie outside of protein-coding regions of the genome. To address these challenges in identifying the genetic factors underlying complex traits, we have developed probabilistic machine learning methods that leverage biological structure and prior knowledge. In this thesis, we describe four applications of such models. First, we present a method for reconstructing causal gene networks from interventional genetic interaction data in model organisms. Here, we are able to identify intricate functional dependencies among hundreds of genes affecting a complex trait. We have applied this method to understanding the genetics of protein folding in yeast, where we demonstrate ability to recapitulate the details, including ordering, of known pathways, and make novel functional predictions. Second, we present PriorNet, a method for incorporating gene network and path- way information into the analysis of population-level studies of genetic variation in human disease. PriorNet utilizes a flexible, Markov Random Field prior to propagate information between functionally related genes and related diseases, in order to improve statistical power in large-scale disease studies. We demonstrate a significant improvement in the discovery of disease-relevant genes in studies of three autoimmune diseases. Next, we extend the intuitions of PriorNet in a method for identifying interactions between genetic variants in human disease, to begin to understand how genes work together in complex disease processes. Our method, GAIT, leverages gene networks, network structure, and other patterns to adaptively prioritize candidate in- teractions for testing, and dramatically reduce the burden of multiple hypothesis correction to identify a large number of interactions in diverse human disease studies. Finally, we discuss the identification of functional variants on a large scale through the use of gene expression as a high-resolution cellular phenotype. We have sequenced RNA from 922 genotyped individuals to provide a direct window into the distribution, properties, and consequences of thousands of regulatory variants affecting diverse gene expression traits including splicing and allelic expression. From the identified variants, we also train a model, LRVM, for predicting regulatory consequences based on location and genomic properties of each variant.
  • Print
    Shafiqul Alam Kiron ; concept and text, Monira Rahman [and three others].
  • Digital
    Katie Planey.
    Subtypes define distinctive subgroups of objects found within a larger cohort; these subtypes can help domain experts define actionable recommendations for each subgroup to improve outcomes. With the relatively recent explosion of large datasets accompanied by large numbers of features, a popular way to define subtypes is unsupervised learning, or clustering, algorithms. Unfortunately, unsupervised learning algorithms have a serious drawback: there is no ground truth. While a set of clusters may correlate strongly with an outcomes variable, an outcomes, or response, variable, is not used in an unsupervised learning algorithm; this means that the accuracy of clusters derived from such algorithms, by nature, cannot be quantified. One way to ensure subtypes represent true signal is to conduct the clustering analysis on multiple datasets. However, there is a lack of methods for unsupervised learning across multiple datasets. In this dissertation, I propose novel methods for unsupervised clustering across multiple datasets, by finding a consensus across clusters derived from each individual dataset. I propose an algorithm, COINCIDE, that encompasses these novel methods; COINCIDE interprets each cluster as a node in a network. I apply COINCIDE to cancer gene expression and pathology datasets, and finally sepsis gene expression datasets, to illustrate the ability of COINCIDE to conduct unsupervised learning across multiple datasets to discover robust subtypes.
  • Digital
    Lucy W. Barrett, Sue Fletcher, Steve D. Wilton.
    Springer2013
    There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns.
  • Digital
    edited by Brian A. Sharpless.
    Oxford Clinical Psychology2017
    Isolated sleep paralysis / Brian A. Sharpless and Dan Denis -- Sexual behaviors in sleep / Elena del Busto, Frederick R. Stoddard II, and Jourdan S. Cruz -- Exploding head syndrome / Brian A. Sharpless and Jacob A. Zimmerman -- Capgras and other misidentification syndromes / Arthur Sinkman -- Attention deficit disorder psychosis / Jan Dirk Blom, Marieke Niemantsverdiret, Anke Spuijbroek, and Sandra Kooji -- Cotard's syndrome / Hans Debruyne -- Persistent genital arousal disorder / David Goldmeier and Shalini Andrews -- Necrophilia / Sara G. West and Phillip J. Resnick -- Frotteurism / Richard McAnulty -- Autoerotic asphyxia and asphyxiophilia / Stephen Hucker -- Koro : a genital retraction syndrome / Petra Garlipp -- Taijin kyofusho / Brian A. Sharpless, Amy L. Balko, and Jessica L. Grom -- Brain fag syndrome / Peter O. Ebigbo, Chimezie Leswas Elekwachi, and Felix Chukwunenyem Nweze -- Jerusalem syndrome and paris syndrome : two extraordinary disorders / Eliezer Witztum and Moshe Kalian -- Dhat syndrome / Rocío Martín-Santos, Ricard Navinés, and Manuel Valdés -- Ataques de nervios / Roberto Lewis-Fernández and Irene López -- Alice in wonderland syndrome / Jan Dirk Blom -- Factitious disorders / Brenda Bursch and Robert Haskell -- Diogenes syndrome / Brian O'Shea -- Pseudologia phantastica : pathological lying / Petra Garlipp -- Body integrity identity disorder / Anna Sedda.
  • Digital
    O.S. Miettinen.
    Springer2011
    Pt. 1. Philosophical propedeutics -- pt. 2. Theory of clinical medicine -- pt. 3. Theory of clinical research -- pt. 4. Contemporary realities in clinical research -- pt. 5. Epilogue on major improvements in clinical medicine -- pt. 6. Appendices.
  • Digital
    Antonella Tosti, Doris Hexsel, editors.
    Springer2013
    This well-illustrated guide provides concise descriptions of the most frequently encountered cosmetic skin conditions and essential information on commonly employed treatment procedures. The book opens with a description of skin evaluation systems and then documents etiology, pathogenesis, diagnosis, and treatment for various conditions, including cellulite, acne, hirsutism, and striae distensae. The second part of the book provides step-by-step guidelines on a range of cosmetic procedures, such as botulinum toxin injection, cryosurgery, electrosurgery, and injection lipolysis. The advice provided will be invaluable for all physicians who intend to incorporate these procedures into their practices. The book will also be of interest to established specialists in cosmetic dermatology wishing to update their knowledge and to all general dermatologists and plastic surgeons required to answer the numerous questions posed by patients seeking to maintain or improve the quality of their skin.
  • Print
    guest editors: Marin H. Kollef ...
  • Digital
    Paola Mastrantonio, Maja Rupnik, editors.
    Springer2018
    This book outlines the currently available clinical, epidemiological and experimental data on Clostridium difficile infection (CDI) with special emphasis on studies and results achieved in Europe. The incidence and severity of CDI has increased significantly over the last decade, and the book explains why C. difficile, recently reclassified as Clostridioides difficile, remains a significant challenge, also from economic perspective, to health care systems all over the world. The different reservoirs of this ubiquitous microorganism are reviewed as well as the different factors contributing to its virulence, such as toxins and biofilm formation. The rapid evolution of antibiotic resistance is clearly a concern and in a specific way can influence the CDI epidemiology. Additionally, new emerging strains and comparative genomics studies are discussed for their relevance from epidemiological and evolutionary point of view. The book also gives an overview on diagnostics, therapy and surveillance, all of which are still challenging. Therefore, a closer look is taken on the effect of probiotics as an alternative to antibiotics, for prevention and treatment of CDI. Fecal transplantation from healthy donors, passive immunotherapies and vaccines for patients with recurrences are also discussed in dedicated chapters. The book closes with a summary of the history and the achievements of the European Society of Clinical Microbiology and Infectious Diseases Study Group for Clostridium difficile (ESGCD) written by the current and past presidents of the Society. It is the aim of this book to raise awareness on CDI and to disseminate updated information on its prevention, diagnosis and treatment.
  • Digital
    Brendon J. Coventry, editor.
    Springer2014
    Written by internationally acclaimed specialists,"Upper Abdominal Surgery" provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated with photographs that depict anatomic or technical principles.
  • Digital
    Shahrokh F. Shariat, Evanguelos Xylinas, editors.
    Springer2015
    Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. Its aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage andpatient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy are covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists, and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
  • Digital
    Michael Grasso III, Demetrius H. Bagley, editors.
    Springer2015
    Upper tract urothelial carcinoma : ureteroscopic biopsy and specimen preparation / Demetrius H. Bagley, Ryuta Tanimoto, and Kelly A. Healy -- Imaging of upper tract transitional cell carcinoma / Sarah L. Steenbergen and Gary Israel -- Cytopathology and management of ureteroscopic biopsy samples / Shuye Ren and Marluce Bibbo -- Ureteroscopic treatment of upper urinary tract urothelial malignancy / Michael Grasso III, Bobby S. Alexander, Lynn J. Paik, and Andrew I. Fishman -- Surgical management of upper tract urothelial carcinoma- open, laparoscopic, and robotic approaches to nephroureterectomy and outcomes / Marc J. Mann, Costas D. Lallas, and Edouard J. Trabulsi -- Surveillance after treatment for upper tract transitional cell carcinoma / Michael J. Conlin and Brian D. Duty -- Topical chemotherapy / John Michael Henderson and Francis X. Keeley Jr. -- Systemic chemotherapy for upper tract urothelial cancer / Jean Hoffman-Censits -- Hereditary upper tract urothelial carcinoma : Lynch syndrome, hereditary nonpolyposis colorectal cancer syndrome (HNPCC) / Scott G. Hubosky and Bruce M. Boman -- Bladder tumors : association with upper tract neoplasms / Christopher B. Anderson, John E. Musser, John P. Sfakianos, and Harry W. Herr -- Enhanced imaging : NBI, PDD, SPIES / Luca Villa, Jonathan Cloutier, and Olivier Traxer -- Beyond endoscopy- ultrasound, optical coherence tomography and confocal laser endomicroscopy / Mieke T.J. Bus, Daniel Martin de Bruin, Guido M. Kamphuis, Theo M. de Reijke, and Jean J.M.C.H de la Rosette -- Diagnostic and treatment algorithm of upper tract urothelial carcinoma / Andrew I. Fishman, Lynn J. Paik, and Michael Grasso III.
  • Digital
    edited by Michael C. Flickinger.
    ProQuest Ebook Central2013
    "This reference work provides information on industrial cell growth, gene expression systems, fermentation media, process development, bioreactor design, process sensing and control, process analytical technologies (PAT) as well as fermentation cGMP operations"-- Provided by publisher.
  • Digital
    Rose, Burton David.
    Database : UpToDate (Firm)
    UpToDate is a web-based, clinical information resource, designed to provide concise, practical answers to clinical questions. The content is updated quarterly. Nearly 3,000 author physicians continually review the literature for material that is well supported by data and would be useful in a clinical setting. If a medical finding is deemed important, it is then added to the relevant topic review(s) after approval by an internal peer review and by the authors. The content is comprehensive, concise, and fully referenced.
  • Digital
    DatabaseNew users must create an UpToDate login while on the campus network, download the app, and sign in. ***Existing UpToDate mobile app users: sign in on wifi, and download content.
    Mobile Application, UpToDate for iOSUsers must register through the campus network, download the app, and sign in. Existing UpToDate mobile app users: sign in on wifi, and download content
    UpToDate is a clinical information resource designed to provide concise answers to clinical questions. With this mobile app users can download the complete UpToDate content to their mobile devices for offline access. No network connection is required for regular use. Wifi is required for the initial download and new content updates. Updates occur automatically when users have active wifi access.
  • Digital
    RAND Corporation, Lisa M. Sontag-Padilla, Rachel M. Burns, Regina A. Shih, Beth Ann Griffin, Laurie T. Martin, Anita Chandra ; University of Tennessee Health Science Center, Frances Tylavsky.
    Machine generated contents note: ch. One Introduction -- The Importance of Examining Early-Childhood Cognitive and Behavioral Development -- The Urban Child Institute and the History of the CANDLE Study -- Purpose of This Report -- Structure of the Report -- ch. Two Study Design and Methods -- Study Design -- Eligibility -- Recruitment -- Data Collection -- Study Population -- Analytic Sample and Attrition over Time -- Approach to Weighting the CANDLE Sample -- Sample Characteristics -- Sample Characteristics Used for Weighting (Age, Race, Education, Income) -- Other Demographic Characteristics of the Mothers in the Sample -- Demographic Characteristics of the Child's Father -- Measures -- ch. Three Prenatal and Birth Measures -- Maternal Baseline Enrollment Data Form -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Labor and Delivery Form -- Background -- Description -- Administration -- Scoring -- Data -- Neonatal Summary Form -- Background -- Description -- Administration -- Data -- ch. Four Child and Family Health -- Child Health Update Form -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Sleep Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Family Health History -- Background -- Description -- Administration -- Data Notes -- Data -- Residence Establishment and Lead Risk Assessment -- Background -- Description -- Administration -- Data Notes -- Data -- Child Exam -- Background -- Description -- Administration -- Data Notes -- Data -- Children with Special Health Care Needs Screener -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Five Child and Family Nutrition -- Block Food Frequency Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Choline Inhibitor Questionnaire -- Background -- Description -- Administration -- Data Notes -- Infant Feeding Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Food Supplement Information -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Six Mother's Mental and Behavioral Health -- Temperament Evaluation of Memphis, Pisa, Paris, and San Diego -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Brief Symptom Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Rosenberg Self-Esteem Scale -- Background -- Description -- Administration -- Data Notes -- Data -- Edinburgh Postnatal Depression Scale -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Seven Cognitive Performance -- Bayley Scales of Infant Development -- Background -- Description -- Administration -- Data Notes -- Data -- Wechsler Abbreviated Scale of Intelligence -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Eight Psychosocial Measures -- Conflict Tactics Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Traumatic Life Events Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Social Support Questionnaire, 6th Edition -- Background -- Description -- Administration -- Data Notes -- Data -- Knowledge of Infant Development Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Household Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Child Abuse Potential Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Parenting Stress Index Short Form -- Background -- Description -- Administration -- Data Notes -- Data -- Parent-Child Interaction Nursing Child Assessment Satellite Training Teaching Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Child Care Information -- Background -- Description -- Administration -- Data Notes -- Data -- Scales of Independent Behavior -- Revised -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Toddler Social Emotional Assessment -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- ch. Nine Implications and Potential Benefits for the CANDLE Study -- Appendix. Biological Samples -- Biologic Measures -- Biological Lead Substudy.
  • Digital
    Baoxue Yang, Jeff M. Sands, editors.
    Springer2014
    The mechanisms and physiological functions of urea transport across biological membranes are subjects of long-standing interest. Recent advances in the molecular biology and physiology of urea transport have yielded new insights into how and why urea moves across cell membranes. In the last two decades, seven facilitated urea transporters (UT-A1-6 and UT-B) have been cloned, and their gene organization, protein crystal structure, expression localization and physiological functions in the tissues have been described. In recent years, the studies in urea transporter knockout mouse models suggest that urea transporters may be useful targets for drug discovery of selective inhibitors. The modulation of urea transport activity by pharmacological agents may provide novel treatments for hypertension, congestive heart failure and other fluid-retaining states. However, although urea represents about 40% of all urinary solutes in normal human urine, the handling of this solute in the tissues has been largely neglected in the past, and few clinical or experimental studies now report data about urea. Most recent physiological textbooks include chapters on water and electrolyte physiology but not a single chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into further mechanisms and the physiological significance of urea metabolism and transport in mammals. The book provides a state-of-the-art report on the latest findings on urea transport and where the field is going. Although some older work is cited, the main focus is on advances made over the past 20 years with regard to the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. These aspects are especially valid, as advances in our understanding of urea transporting mechanisms and physiology promise to yield new insights into biology and medicine.
  • Digital
    Sutchin R. Patel, Stephen Y. Nakada.
    Springer2015
    Providing a complete updated roadmap to treating ureteral stones, Ureteral Stone Management: A Practical Approach presents newer topics focusing of the recent improvements in instrumentation and adjunctive equipments, managing radiation to both patient and urologist, as well as reviews of the most recent studies on urologic practices. Ureteral Stone Management: A Practical Approach assists the reader in a logical and step wise pathway for selecting the best treatment options and how to work through complications. This evidence-based text is valuable to all those working in the field of urology.
  • Digital
    Saverio Pagano ; con la collaborazione di Paolo Rovellini e Pantaleo Ruggeri ; presentazione a cura di Giuseppe Martorana.
    Springer2010
  • Digital
    Ravi Kulkarni.
    Wiley2017
    Anatomy of the Human Ureter / Ravi Kulkarni -- Anatomic Variations of the Ureter / Piruz Motamedinia, David A Leavitt, Philip T Zhao, Zeph Okeke, Arthur D Smith -- The Pathophysiology of Upper Tract Obstruction / Alexander P Jay, David L Nicol -- Physiology of the Human Ureter / Robin Cole -- Etiology of Ureteric Obstruction / Philip T Zhao, David A Leavitt, Piruz Motamedinia, Zeph Okeke, Arthur D Smith -- The Role of the Interventional Radiologist in Managing Ureteric Obstruction / Stephen Perrio, Alex Chapman -- Emergency Management of Ureteric Obstruction / Steeve Doizi, Margaret S Pearle -- The History and Evolution of Ureteral Stents / Husain Alenezi, John D Denstedt -- Ureteral Stent Materials / Andrew M Todd, Bodo E Knudsen -- Physical Characteristics of Stents / Chad M Gridley, Bodo E Knudsen -- Coated and Drug-Eluting Stents / Thomas O Tailly, John D Denstedt -- Coated and Drug-Eluting Ureteric Stents / Panagiotis Kallidonis, Wissam Kamal, Vasilis Panagopoulos, Evangelos Liatsikos -- Ureteric Stents / Ravindra Sabnis -- Ethical Issues in Ureteric Stenting / Ravi Kulkarni -- Equipment and Technical Considerations During Ureteric Stenting / Jonathan Cloutier, Olivier Traxer -- Extra-Anatomic Stent Urinary Bypass / Stuart Nigel Lloyd -- Detour Extra-Anatomical Ureteric Stent / Graham Watson -- Tandem Ureteral Stents / David A Leavitt, Piruz Motamedinia, Philip T Zhao, Zeph Okeke, Arthur D Smith -- Biodegradable Ureteric Stents / David I Harriman, Ben H Chew -- Metallic Ureteric Stents / Ravi Kulkarni -- Removal of Ureteric Stents / Ravi Kulkarni -- Encrustation of Indwelling Urinary Devices / Justin Chan, Dirk Lange -- Stent Migration / Ravi Kulkarni -- Health-Related Quality of Life and Ureteric Stents / Aditya Raja, Hrishi B Joshi -- Evidence Base for Stenting / Rami Elias, Edward D Matsumoto -- Robotic Ureteric Reconstruction / Helena Gresty, Navroop Johal, Pardeep Kumar -- Indwelling Ureteric Stents -- Health Economics Considerations / Dominic A Teichmann, Hrishi B Joshi -- Ureteric Stents / Ravi Kulkarni.
  • Digital
    Manoj Monga, editor.
    Springer2013
    Ureteroscopy: Indications, Instrumentation & Technique provides a comprehensive and state-of-the-art review of ureteroscopy and will serve as a valuable resource for urologists throughout the world. The volume provides evidence based outcomes to support the expanding indications for ureteroscopy as well as a strong emphasis on appropriate patient selection. The book also provides detailed recommendations for the step-by-step approach to ureteroscopy from both an instrumentation and techniques perspective. The work is extensively illustrated with endoscopic images and includes a DVD of video clips which further highlight the clinical application of available endoscopic techniques. The text also includes highly practical presentations of complex endourologic case presentations with expert analysis and editorial commentary. Example cases would include common but challenging cases of ureteroscopy for transitional cell cancer, horseshoe kidneys, hutch diverticulum, and pregnancy. Ureteroscopy: Indications, Instrumentation & Technique provides a unique and valuable resource in the field of ureteroscopy and will include basic instructions for those currently in training or those who have yet to adapt intrarenal ureteroscopy into their surgical armamentarium. Advanced ureteroscopic approaches are also covered for those wishing to enrich their current clinical expertise.
  • Digital
    edited by Steven B. Brandes.
    Springer2008
  • Digital
    sous la direction de Jean-Paul Beregi ; avec la collaboration des membres de la SFICV.
    Springer2009
  • Digital
    James E. Fitzpatrick, Whitney A. High, W. Lamar Kyle.
    ClinicalKey2018
    1. Introduction to clinical dermatology -- 2. Diagnostic techniques -- 3. Morbilliform eruptions -- 4. Diffuse or reticulated erythema -- 5. Urticarial and indurated eruptions -- 6. Papular eruptions: no scale -- 7. Scaly papular lesions -- 8. Plaques with scale -- 9. Scaly disorders -- 10. Dermatitis (eczematoid reactions) -- 11. Blisters and vesicles -- 12. Pustular eruptions, nonfollicular -- 13. Abcesses -- 14. Necrotic and ulcerative skin disorders -- 15. Subcutaneous diseases -- 16. Annular and targetoid lesions -- 17. Linear and serpiginous lesions -- 18. Sporotrichoid disorders -- 19. Photosensitive disorders -- 20. Purpuric and hemorrhagic disorders -- 21. Sclerosing and fibrosing disorders -- 22. Atrophic disorders -- 23. Follicular disorders -- 24. Alopecia -- 25. Nail disorders -- 26. Infestations, stings, and bites -- 27. Discolorations of the skin -- 28. Papillomatous and verrucous lesions -- 29. Tumors with scale -- 30. Papular and nodular growths without scale -- 31. Pigmented lesions -- 32. Vascular tumors -- 33. Yellow lesions -- 34. Cysts and sinuses -- 35. Subcutaneous lumps -- 36. Cutaneous diseases of travelers -- 37. Topical treatment pearls -- Additional Conditions.
  • Digital
    [edited by] Robert Olympia, Rory O'Neill, Matthew Silvis.
    ScienceDirect2018
    ClinicalKey2018
    Section I. Adult urgent care medicine -- Section II. Pediatric urgent care medicine -- Section III. Sports-related complaints -- Section IV. Procedures -- Section V. Miscellaneous -- Index.
  • Digital
    volume editors, Alejandro Treviño-Becerra, Kunitoshi Iseki.
    Karger2018
    Renal handling of uric acid / Andrade Sierra, J., Flores Fonseca, M.M. -- Renal effects of hyperuricemia / Méndez Landa, C.E. -- The pathophysiology of uric acid on renal diseases / Sánchez-Lozada, L.G. -- Uric acid : the unknown uremic toxin / Treviño-Becerra, A. -- The association between serum uric acid and renal damage : the Takahata study : new insights / Konta, T., Kamei, K., Ichikawa, K., Kayama, T., Kubota, I. -- Significance of hyperuricemia among community-based screening participants / Iseki, K. -- Hyperuricemia and progression of chronic kidney disease : role of phenotype transition of renal tubular and endothelial cells / Kang, D.-H. -- Time to target uric acid to retard chronic kidney disease progression / Uchida, S., Kumagai, T., Chang, W.X., Tamura, Y., Shigeru, S. -- Uric acid : the lower the better? / Bellomo, G., Selvi, A. -- Gout : a disease of kings / Tang, S.C.W. -- Systemic implications of hyperuricemia / Tamayo y Orozco, J.A. -- Uric acid as a cause of the metabolic syndrome / King, C., Lanaspa, M.A., Jensen, T., Tolan, D.R., Sánchez-Lozada, L.G., Johnson, R.J. -- Uric acid and diabetic nephropathy risk / Mauer, M., Doria, A. -- Uric acid in pregnancy : new concepts / Moreno Santillan, A.A., Briones Garduño, J.C., Diaz de Leon, M.A. -- Uric acid renal lithiasis : new concepts / Pazos Pérez, F. -- Clinical significance of serum uric acid levels in Mexican young adults / Alegría-Díaz, A., Valdez-Ortiz, R., Murguía-Romero, M., Jiménez-Flores, R., Villalobos-Molina, R., Mummidi, S., Duggirala, R., López-Alvarenga, J.C., Pérez-Navarro, M. -- Treatment of hyperuricemia in chronic kidney diseases and outcomes / Ramirez-Sandoval, J.C., Madero, M.
  • Print
    Susan King Strasinger, Marjorie Schaub Di Lorenzo.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Sanjay Razdan.
    Springer2016
    Anatomic Foundations and Pathophysiology of Urinary Continence -- Preoperative Assessment and Intervention:Optimizing Outcomes for Early Return of Urinary Continence -- Preoperative Assessment and Intervetion: Optimizing Outcomes for Early Return of Erectile Function -- Pathophysiology of Nerve Injury and Its Effect on Return of Erectile Function -- Technical Innovations to Optimize Early Return of Urinary Continence -- Technical Innovations to Optimize Early Return of Erectile Function -- Oncologic Outcomes of Robotic Radical Prostatectomy: The "Balancing Act" of Achieving Cancer Control and Minimizing Collateral Damage -- Adjunctive Measures to Optimize Early Return of Urinary Continence -- Adjunctive Measures and New Therapies to Optimize Early Return of Erectile Function.
  • Digital
    Jaspreet S. Sandhu, editor.
    Springer2016
    1. Introduction: urinary function alterations in men with prostate cancer -- 2. Post-prostatectomy incontinence initial evaluation -- 3. Urinary incontinence: conservative and medical management and injectable therapy -- 4. Urinary dysfunction in prostate cancer: male slings -- 5. Artificial urinary sphincter: patient selection and surgical technique -- 6. Troubleshooting and optimizing outcomes after artificial urinary sphincter -- 7. Management of vesicourethral anastomotic stricture -- 8. Rectourethral fistula -- 9. Reoperative anti-incontinence surgery -- 10. Post-RT urinary incontinence and stricture -- 11. A case-based illustration of urinary symptoms following radiation therapy for prostate cancer -- Index.
  • Digital
    Karl-Erik Andersson, Martin C. Michel, editors.
    Springer2011
    The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike.
  • Digital
    Donna E. Hansel, Jesse K. McKenney, Andrew J. Stephenson, Sam S. Chang, editors.
    Springer2012
    Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.
  • Digital
    Abhay Rané, Ranan Dasgupta, editors.
    Springer2013
    The causative organisms of Urinary Tract Infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treatment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Urinary Tract Infections addresses key questions facing physicians about this condition. This book is written primarily for general physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also find the book useful as a quick reference guide.
  • Digital
    edited by Matthew A. Mulvey, David J. Klumpp, Ann E. Stapleton.
    Am Soc Microbiol2017
    1. Anatomy and physiology of the urinary tract: relation to host defense and microbial infection -- 2. Clinical presentations and epidemiology of urinary tract infections -- 3. Diagnosis, treatment, and prevention of urinary tract infection -- 4. Urinary tract infections in infants and children -- 5. The vaginal microbiota and urinary tract infection -- 6. Asymptomatic bacteriuria and bacterial interference -- 7. Bacterial prostatitis: bacterial virulence, clinical outcomes, and new directions -- 8. Urosepsis: overview of the diagnostic and treatment challenges -- 9. Reservoirs of extraintestinal pathogenic Escherichia coli -- 10. Origin and dissemination of antimicrobial resistance among uropathogenic Escherichia coli -- 11. Population phylogenomics of extraintestinal pathogenic Escherichia coli -- 12. Virulence and fitness determinants of uropathogenic Escherichia coli -- 13. Uropathogenic Escherichia coli-associated exotoxins -- 14. Structure, function, and assembly of adhesive organelles by uropathogenic bacteria -- 15. Pathoadaptive mutations in uropathogenic Escherichia coli -- 16. Invasion of host cells and tissues by uropathogenic bacteria -- 17. Proteus mirabilis and urinary tract infections -- 18. Epidemiology and virulence of Klebsiella pneumoniae -- 19. Gram-positive uropathogens, polymicrobial urinary tract infection, and the emerging microbiota of the urinary tract -- 20. Integrated pathophysiolog of pyelonephritis -- 21. Susceptibility to urinary tract infection: benefits and hazards of the antibacterial host response -- 22. Innate immune responses to bladder infection -- 23. Host responses to urinary tract infections and emerging therapeutics: sensation and pain within the urinary tract -- 24. Drug vaccine development for the treatment and prevention of urinary tract infections -- Index.
  • Digital
    Nagaraja P. Rao, Glenn M. Preminger, John P. Kavanagh, editors.
    Springer2011
    This book constitutes more than a quarter of urologists, workload in the Western countries and is more than half in the Middle-East and Central Asian countries. The surgical management of stone disease has changed considerably in the last five years and our understanding of mechanism of stone disease has improved with some old concepts discarded and newer theories gaining ground. Covering the entire spectrum of urinary stone disease and with contributions of more than fifty internationally recognised experts, this exhaustive and complex reference work will be invaluable to all urologists, nephrologists and non-medical scientists.
  • Digital
    Youhe Gao, editor.
    Springer2015
    This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".
  • Digital
    Bernd Hamm [and others] ; [translator, Bettina Herwig].
    Thieme MedOne Radiology2008
  • Digital
    Kate H. Moore.
    Springer2013
    Taking the history -- Physical examination -- How to manage the patient after history and examination -- How to conduct urodynamic studies: essentials of a good urodynamic report -- Outcome measures used to assess response -- Conservative therapy of urodynamic stress incontinence -- Step-by-step guide to treatment of overactive bladder (OAB)/Detrusor overactivity -- Anal incontinence and disorders of obstructive defecation -- Surgery for urodynamic stress incontinence -- Management of prolapse -- Recurrent bacterial cystitis in women -- Interstitial cystitis.
  • Digital
    [edited by] Mark D. Walters, Mickey M. Karram.
    ClinicalKey2015
    Historical milestones in female pelvic surgery, gynecology, and female urology -- Anatomy of the lower urinary tract, pelvic floor, and rectum -- Embryology and congenital anomalies of the urinary tract, rectum, and female genital system -- Neurophysiology and pharmacology of the lower urinary tract -- Physiology of the pelvic muscles, vagina, and anorectum -- Female sexual function and dysfunction : assessment and treatment -- Epidemiology and psychosocial impact of female pelvic floor disorders -- Description and classification of lower urinary tract dysfunction and pelvic organ prolapse -- Evaluation of urinary incontinence and pelvic organ prolapse : history, physical examination, and office tests -- Urodynamics : indications, techniques, interpretation, and clinical utility -- Video and ambulatory urodynamics -- Endoscopic evaluation of the lower urinary tract -- Radiologic studies of the lower urinary tract and pelvic floor -- Neurophysiologic testing for pelvic floor disorders -- Pathophysiology of urinary incontinence -- Obstetrics and pelvic floor disorders -- Stress urinary incontinence and pelvic organ prolapse : nonsurgical management -- Retropubic operations for stress urinary incontinence -- Biologic bladder neck sling for stress urinary incontinence -- Synthetic midurethral slings for stress urinary incontinence -- Laparoscopic and robotic surgery for pelvic organ prolapse and stress urinary incontinence -- Urethral injection of bulking agents for intrinsic sphincter deficiency -- Surgical treatment of anterior vaginal wall prolapse -- Surgical treatment of rectocele and perineal defects -- Surgical treatment of vaginal apex prolapse -- Uterine conservation for the surgical treatment of uterovaginal prolapse -- Obliterative procedures for pelvic organ prolapse -- The use of biologic tissue and synthetic mesh in urogynecology and reconstructive pelvic surgery -- Avoiding and managing lower urinary tract injuries during pelvic surgery -- Managing mesh and other complications after surgeries for urinary incontinence and pelvic organ prolapse -- Fecal incontinence -- Constipation -- Rectovaginal fistula and perineal breakdown -- Rectal prolapse -- Overactive bladder syndrome and nocturia -- Hypersensitivity disorders of the lower urinary tract -- Surgical management of detrusor compliance abnormalities -- Voiding dysfunction and urinary retention -- Lower urinary tract infection -- Urethral diverticula -- Lower urinary tract fistulas -- The effects of gynecologic cancer on lower urinary tract function -- Bladder drainage and urinary protective methods -- Outcomes and quality-of-life measures in pelvic floor research -- The standardization of terminology of lower urinary tract function recommended by the international continence society -- The standardization of terminology of lower urinary tract function: report from the standardization subcommittee of the international continence society -- Standardization reports of the international continence society (ICS) -- Classification system of vaginal prostheses and graft complications recommended by the International Urogynecological Association (IUGA) and International Continence Society (ICS) -- Sample questionnaires for several recommended outcome measures for women with pelvic floor disorders.
  • Digital
    Michael E. Moran.
    Springer2014
    Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.
  • Digital
    Jamsheer J. Talati, Hans-Goran Tiselius, David M. Albala, Zhangqun Ye, editors.
    Springer2012
    Urolithiasis: Basic Science and Clinical Practice is a comprehensive text that assists urologists in defining the best choice of treatment for each case through a balanced presentation of underlying science, diagnostic methods and practical tips, with additional discussions on educational issues, costs and management of resources. This user-friendly practical resource is replete with full-color illustrations and radiographs, covering all aspects of stone disease, and offering perspectives from Europe, the Americas, China, South Asia, Africa, and Australia. Topics include the biochemical and physiological basis of stone formation, treatment options, complications, assessment of techniques and technologies available, and guidelines on the prevention of stone recurrence. Urolithiasis: Basic Science and Clinical Practice is the definitive text on stone disease and is a must read for young consultants starting a new practice, and urologists in residence and training.
  • Print
    authors, Robert O. Petersen, Isabell A. Sesterhenn, Charles J. Davis, Jr.
    Status: Not Checked OutLane Catalog Record
    Kidney -- Renal pelvis and ureter -- Urinary bladder -- Urethra -- Testis -- Testicular adnexa -- Prostate -- Seminal vesicles -- Penis -- Scrotum.
  • Digital
    edited by Jeffrey A. Stock, Michael P. Esposito, Vincent J. Lanteri ; foreword by David M. Albala.
    Springer2008
  • Digital
    Prokar Dasgupta, editor ; foreword by James O. Peabody and Mani Menon.
    Springer2008
  • Digital
    [edited by] John B. Gebhart ; illustrated by Joe Chovan.
    ClinicalKey2010
    Anatomy of the female urinary tract / John A. Occhino, Christine A. Heisler, and John B. Gebhart -- Imaging of the female urinary tract / Bohyun Kim, John B. Gebhart, and Akira Kawashima -- Cystourethroscopy for the gynecologist / Gamal M. Ghoniem and John B. Gebhart -- Reconstructive procedures performed on the urethra / John B. Gebhart -- Surgical procedures performed on the urinary bladder / Christopher J. Klingele and John B. Gebhart -- Avoiding and managing ureteral injury during pelvic surgery / Emanuel C. Trabuco and John B. Gebhart.
  • Print
    [edited by] David G. Bostwick, Liang Cheng.
    Status: Not Checked OutLane Catalog Record
  • Digital
    [edited by] David G. Bostwick, Liang Cheng.
    ClinicalKey2014
    Nonneoplastic disease of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Gregory T. MacLennan and Liang Cheng -- Renal pelvis and ureter / Stephen M. Bonsib and Liang Cheng -- Fine needle aspiration of the kidney / Andrew A. Renshaw -- Nonneoplastic disorders of the urinary bladder / Robert H. Young -- Neoplasms of the urinary bladder / Liang Cheng, Antonio Lopez-Beltran, Gregory T. MacLennan, Rodolfo Montironi, and David G. Bostwick -- Urine cytology / Deloar Hossain, David Hull, and David G. Bostwick -- Nonneoplastic diseases of the prostate / David G. Bostwick, David Hull, Jun Ma, and Deloar Hossain -- Neoplasms of the prostate / David G. Bostwick, Liang Cheng, and Isabelle Meiers -- Seminal vesicles / David G. Bostwick -- Urethra / Victor E. Reuter -- Nonneoplastic diseases of the testis / Manuel Nistal, Ricardo Paniagua, and Pilar Gonzalez-Peramato -- Neoplasms of the testis / Thomas M. Ulbright and Robert E. Emerson -- Spermatic cord and testicular adnexae / David G. Bostwick -- Penis and scrotum / Jae Y. Ro, Mukul Divatia, Kyu-Rae Kim, Mahul B. Amin, and Alberto G. Ayala -- Adrenal glands / Ernest E. Lack and Edina Paal.
  • Digital
    Said Abdallah Al-Mamari, Salim Said Al-Busaidy, editors.
    Springer2015
    Part 1. Prostate Cancer -- 1. Epidemiology, Etiological factors, Prevention -- 2. PSA Biology and Prostate Cancer Screening -- 3. Symptoms, Signs, Clinical Examination, Primary Diagnostic Methods and Disease Extention Investigations -- 4. Prostate Cancer Treatment.- Part 2. Bladder tumour -- 5. Epidemiology, Pathology, Etiological factors, Prevention, Screening, Symptoms and Signs -- 6. Investigations (Lab and Radiology) -- 7. Bladder Tumour Treatment -- 8. Non-Urothelial Bladder Cancers -- Part 3. Upper Tract Urothelial Carcinomas -- 9. Epidemiology, Risk Factors, Pathology, Tumour Staging -- 10. Diagnosis of UTUC -- 11. Treatment of UTUC, Prognosis and Follow-Up -- Part 4. Renal Cell Carcinomas -- 12. Epidemiology, Etiology -- 13. Pathology, Genetic Profile, Hereditary Syndromes -- 14. Clinical Features -- 15. Physical Examination, Laboratory and Radiological Investigations -- 16. Treatment of Renal Cell Carcinomas.- Part 5. Male Genital Cancer -- 17. Epidemiology and Etiology of Testicular Cancer -- 18. Histological Classification of Testicular Cancer -- 19. Clinical Presentation of Testicular Tumours and Spreading Patterns.- 20. Diagnostic Approaches of Testicular Cancer -- 21. Staging and Risk Categories of Testicular Cancer -- 22. Treatment of Testicular Cancer -- 23. Extra-Gonadal Germ Cell Tumours -- 24. Penile Cancer.- Part 6. Adrenal Gland Cancer -- 25. Epidemiology, Aetiological Factors, Symptoms and Signs of Adrenocortical Carcinomas (ACC) -- 26. Investigations of ACC -- 27. Treatment of Adrenal Gland Cancer -- 28. Malignant Pheochromocytoma -- Part 7. Clinical Scenarios -- 29. Scenarios and Questions -- 30. Proposed Answers.
  • Digital
    Hunter Wessells, editor.
    Springer2013
    Urological Emergencies: A Practical Approach, Second Edition provides a concise, evidence based review of common urgent and emergent urological conditions in children and adults. Descriptions of the appropriate diagnostic and therapeutic considerations on topics of traumatic, infectious, obstructive, hemorrhagic, iatrogenic, vascular and congenital urological emergencies in adults and children are provided. The text is organized by pathophysiology rather than organ system, allowing the reader to develop approaches to the care of patients with acute urological conditions based on mechanism of disease. Relevant pathophysiological background and epidemiology are reviewed, necessary diagnostic testing recommended, and detailed medical, surgical and endourological management approaches have been provided. All chapters incorporate published guidelines and best practice recommendations from appropriate organizations including the American Urological Association, the Centers for Disease Control and Prevention, and various International Consultations on Urological Diseases. New or significantly revised chapters in each of the subsections address innovations in trauma care and prevention, new strategies in management of kidney stones, and special care needs of children with acute urological problems. Urological Emergencies: A Practical Approach, Second Edition is of great value to practicing urologists, urology residents, emergency medicine trainees and practitioners, and primary care providers including MD's, PA's, and NP's without immediate access to urological consultation.
  • Digital
    Armenakas, Noel; Cowan, Nigel C.; Hashim, Hashim; Reynard, John; Wood, Dan.
    Springer2013
    Presenting Symptoms of Urological Emergencies / Hashim Hashim -- Lower Urinary Tract Emergencies / John Reynard -- Nontraumatic Renal Emergencies / John Reynard -- Other Infective Urological Emergencies / Hashim Hashim -- Traumatic Urological Emergencies / Noel Armenakas -- Scrotal and Genital Emergencies / John Reynard -- Postoperative Emergencies After Urological Surgery / Hashim Hashim -- Ureteric Colic in Pregnancy / Dan Wood -- Management of Urological Neoplastic Conditions Presenting as Emergencies / Dan Wood -- Pediatric Emergencies / Dan Wood -- Common Emergency Urological Procedures / John Reynard.
  • Digital
    editor: Daniel A. Shoskes.
    Springer2012
    Evidence-Based and Age-Appropriate Preventive Health Evaluations in Men / Raul J. Seballos -- Clinical Testing of Endothelial Function in Erectile Dysfunction / Titte R. Srinivas and Mark S. Segal -- Controversies and Opportunities for PSA Screening / Benjamin Cohen and Eric A. Klein -- A Phenotypic Approach to the Evaluation and Treatment of Men with Chronic Pelvic Pain Syndrome / Kiranpreet Khurana and Daniel A. Shoskes -- Recurrent Urinary Tract Infections in Men / Stacey C. Carter, Mya E. Levy and Scott I. Zeitlin -- Evaluation and Medical Management of BPH and LUTS in Men / Bilal Chughtai, Richard Lee, Matthew Hall and Alexis E. Te -- The Surgical Treatment of Benign Prostatic Hyperplasia / James C. Ulchaker -- Rational Herbal and Complementary Interventions for Prevention and Treatment of Urological Disorders in Men / Mark A. Moyad -- Androgen Decline in the Aging Male: Making Sense of the "Male Menopause" / Daniel A. Shoskes -- Evaluation and Treatment of Peyronie's Disease / Lawrence S. Hakim -- Primary Care Evaluation and Treatment of Erectile Dysfunction / Martin Miner and Jacob Rajfer -- Surgical Treatment for Erectile Dysfunction / Drogo K. Montague -- Managing Overactive Bladder and Urinary Incontinence in the Male / Humphrey Atiemo and J. Quentin Clemens -- Treatment of Localized Prostate Cancer / Andrew J. Stephenson -- Management of Urethral Strictures in Men / Richard A. Santucci and Mang L. Chen -- Medical and Surgical Interventions in Male Fertility / Kevin Chandler and Edmund Sabanegh Jr. -- Evaluation and Therapy of Chronic Scrotal Content Pain and Epididymitis / Jonas S. Benson and Laurence A. Levine -- Psychosocial Factors in Painful Urogenital Conditions in Men / Dean A. Tripp and Jessica Ginting.
  • Digital
    Vinod H. Nargund, Derek Raghavan, and Howard M. Sandler (eds.).
    Springer2008
  • Digital
    V.H. Nargund, D. Raghavan, H.M. Sandler, editors.
    Springer2015
    With a fully updated look at urological cancers and a comprehensive approach to the basic principles behind chemotherapy, radiotherapy and gene therapy, Urological Oncology, 2nd Edition addresses the advances in MRI, hormone therapy, anesthesia for minimally invasive surgery, drug trials, new therapeutic techniques as well as the new histological types of renal cancer, bringing this second edition fully up-to-date with current practices. Through investigations and multidisciplinary management, Urological Oncology, 2nd Edition reflects the editors? vast experience in treating all urological cancers, and the broad international contributions reflect the urological oncology practice in other developed countries including the United States. Urological Oncology, 2nd Edition will be a valuable tool for residents, specialists, nurse practitioners and other medical personnel in Urology, Radiotherapy, Oncology and Palliative Medicine involved in the treatment of urological cancers.
  • Digital
    Michael T. Macfarlane, M.D., Louisville, Kentucky.
    Ovid2013
    The Fifth Edition of Urology in the House Officer Series creates a concise source of clinical information on urology for medical students and residents that can be easily carried for quick reference. Concentrating on the non-surgical aspects of urology, this pocket guide provides the information needed for making a diagnosis and deciding on the proper treatment course. This compact book is separated into two sections, the first, entitled Chief Presentations, covers the most common presenting complaints in the general urology clinic. The second section, entitled, Selected Topics, covers the major areas of urology in greater detail. Covering all diagnostic and treatment approaches for all urologic diseases, this pocket guide is also ideal for family practitioners, physician assistants, nurse practitioners, and emergency room physicians who wish to quickly review a specific urologic presentation.
  • Digital
    Axel S. Merseburger, Markus A. Kuczyk, Judd W. Moul, editors.
    Springer2014
    Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds, and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations, many of them in color, are also included. The editors and authors are leading urological surgeons and oncologists and internationally recognized authorities in their fields. This book will be a great asset in every urologist?s office and will also prove invaluable for practitioners in related disciplines.
  • Digital
    [edited by] Ming Zhou, George J. Netto, Jonathan I. Epstein.
    ClinicalKey2012
    Nonneoplastic disease of the prostate -- Neoplastic disease of the prostate -- Seminal vesicles -- Nonneoplastic disease of the urinary bladder -- Neoplastic disease of the urinary bladder -- Nonneoplastic disease of the kidney -- Neoplastic disease of the kidney -- Renal pelvis and ureter -- Nonneoplastic disease of the testis -- Neoplastic disease of the testis -- Spermatic cord and testicular adnexa -- Disease of the penis, urethra, and scrotum -- Soft tissue tumors and lymphomas.
  • Digital
    [edited by] Torsten Zuberbier, Clive Grattan, Marcus Maurer.
    Springer2010
    History of Urticaria / M. Greaves -- Aetiopathogenesis of Urticaria / Clive E. H. Grattan -- Classification of Urticaria / Torsten Zuberbier -- Impact of Urticaria: QOL and Performance / Ilaria Baiardini, Fulvio Braido and Giorgio Walter Canonica -- Acute Urticaria / Torsten Zuberbier -- Chronic Urticaria / Marcus Maurer -- Dermographic and Delayed Pressure Urticaria / Frances Lawlor -- Heat and Cold Urticaria / Carsten Bindslev-Jensen -- Solar Urticaria / Tatsuya Horikawa, Atsushi Fukunaga and Chikako Nishigori -- Cholinergic Urticaria and Exercise-Induced Anaphylaxis / Ruth A. Sabroe -- Contact Urticaria / Jürgen Grabbe -- Urticarial Syndromes and Autoinflammation / Kanade Shinkai and Kieron S. Leslie -- Urticaria Vasculitis / Lluís Puig -- Angioedema / Elena Borzova and Clive E. H. Grattan -- Therapy of Urticaria / Bettina Wedi -- Standard Operating Procedures: A Practical Approach / M. Metz and M Magerl.
  • Digital
    Birgit Völlm, Norbert Nedopil, editors.
    Springer2016
  • Digital
    edited by Jennifer A Doudna and Erik J Sontheimer.
    ScienceDirect2014
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.
  • Digital
    [By R. Bethene Ervin, Jacqueline D. Wright, and Jocelyn Kennedy-Stephenson].
  • Digital
    Sandra R. Wilson, Norma Starr-Schneidkraut, Michael D. Cooper ; submitted to Elliot R. Siegel.
    NLM1989
  • Print
    Abraham Flexner ; with a companion essay by Robbert Dijkgraaf.
    Status: Not Checked OutLane Catalog Record
    A forty-year tightening of funding for scientific research has meant that resources are increasingly directed toward applied or practical outcomes, with the intent of creating products of immediate value. In such a scenario, it makes sense to focus on the most identifiable and urgent problems, right? Actually, it doesn't. In his classic essay "The Usefulness of Useless Knowledge," Abraham Flexner, the founding director of the Institute for Advanced Study in Princeton and the man who helped bring Albert Einstein to the United States, describes a great paradox of scientific research. The search for answers to deep questions, motivated solely by curiosity and without concern for applications, often leads not only to the greatest scientific discoveries but also to the most revolutionary technological breakthroughs. In short, no quantum mechanics, no computer chips. This brief book includes Flexner's timeless 1939 essay alongside a new companion essay by Robbert Dijkgraaf, the Institute's current director, in which he shows that Flexner's defense of the value of "the unobstructed pursuit of useless knowledge" may be even more relevant today than it was in the early twentieth century. Dijkgraaf describes how basic research has led to major transformations in the past century and explains why it is an essential precondition of innovation and the first step in social and cultural change.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.