- Ubiquitin and protein degradation. Part A-B — Understanding the interaction between graft placement, gait mechanics, and cartilage morphology as a pathway to osteoarthritis in the ACL reconstructed knee (100)
- Understanding the mechanis of mammalian damage tolerance proteins in suppressing damage-specific mutagenesis — Using R for data management, statistical analysis, and graphics (100)
- Using R for numerical analysis in science and engineering — Uveitis-- fundamentals and clinical practice. 4th ed. (30)
- Understanding the mechanis of mammalian damage tolerance proteins in suppressing damage-specific mutagenesis2012Jia-Ren Lin.Post-replication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18-mediated translesion synthesis (TLS) are two forms of PRR. Two Rad5-related proteins, SHPRH and HLTF, have been identified in mammalian cells, but their specific roles in PRR are unclear. Here, we show that HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV and MMS, respectively. Following UV, HLTF enhances PCNA monoubiquitination and recruitment of TLS polymerase eta, while also inhibiting SHPRH function. In contrast, MMS promotes the degradation of HLTF and the interactions of SHPRH with Rad18 and polymerase kappa. Our data not only suggest that cells differentially utilize HLTF and SHPRH for different forms of DNA damage, but also, surprisingly, that HLTF and SHPRH may coordinate the two main branches of PRR to choose the proper bypass mechanism for minimizing mutagenesis. Though the degradation of HLTF is required for the SHPRH-Rad18 interaction in MMS-damaged cells, knockdown of HLTF is not sufficient to induce SHPRH-Rad18 binding in undamaged cells. Thus, an unidentified factor, in addition to HLTF degradation, is required to fully activate SHPRH and Rad18 upon MMS damage. We have noticed that Rad18 is deubiquitinated after MMS treatment, and that this de-ubiquitination is correlated with the degree of Rad18-SHPRH interaction. Moreover, we show that promoting the ubiquitination of Rad18 has an inverse effect on the interaction with SHPRH both in vitro and in cells. Surprisingly, though, the ubiquitinated Rad18 shows a stronger self-interaction than the wild-type Rad18, opposite from the SHPRH binding results. As the zinc-finger motif of Rad18 has been previously shown to bind ubiquitin, this may be a logical mechanism to control the switch between Rad18 dimerization and its interaction with other proteins. Interestingly, ubiquitinated Rad18 appears to be inactive, not only from loss of its ability to interact with SHPRH, but also through the inability to form damage foci and suppress MMS-induced mutagenesis. Altogether, our data reveal a unique regulation of Rad18 through self-ubiquitination and dimerization. In summary, our studies have revealed a number of new mechanistic insights into the post-replication repair pathways in human cells, including the interesting conclusion that protein degradation, deubiquitination, and other key cell processes may be controlled in a DNA damage-specific manner.
- 2013Ruth Sommese.Heart disease is one of the leading causes of morbidity and mortality in the developed world. As such, significant amount of resources and energy are funneled into developing treatments and therapeutics. While genetically caused cardiovascular diseases manifest at the tissue level, the fundamental mechanism that triggers the secondary effects and tissue remodeling generally occurs at the protein level. It is therefore critical to understand the molecular changes on the basic biochemical and biophysical level and connect these to the cellular and developmental disease processes. One such cardiovascular disorder is hypertrophic cardiomyopathy or HCM, which has been estimated to affect approximately 1 in 500 individuals. It disproportionately affects young adults and is the leading cause of sudden cardiac death. Since the first case of genetically linked HCM was identified in the early 1990s, a significant amount of work has been done to understand the molecular mechanism of the disease. Mutations have been identified in the proteins comprising the contractile apparatus of the muscle, the sarcomere. One such protein is [beta]-cardiac myosin, which has been recognized as a significant culprit of genetically linked HCM (~30-50%). Many studies have been performed to understand how single point mutations can alter the enzymatic and mechanical properties of this motor protein, but there is no clear consensus about the molecular mechanism. This has been due mainly to the lack of available human [beta]-cardiac myosin and the use of non-human and non-[beta]-cardiac myosin. Non-human and non-[beta]-cardiac myosin from common animal models differ by >30 residues, and as clearly evident from the disease and from previous studies on myosin, a single amino acids mutation can significantly alter and disrupt myosin function. During my thesis work, I have performed the first biochemical and biophysical work in the field looking at cardiomyopathy mutations using human [beta]-cardiac myosin. I have shown that HCM-causing [beta]-cardiac myosin mutations result in a gain of function, increasing the power or work output of the myosin. I have also examined HCM-causing mutations in troponin T, a component of the thin filament regulatory unit, using human [beta]-cardiac myosin. In the muscle, the interaction of myosin and actin is regulated by calcium through the thin filament proteins, namely the troponin complex and tropomyosin. HCM-causing mutations in troponin T increase calcium sensitivity or the number of force-producing heads that can interact with actin, thereby also increasing force or power output in the muscle. My work not only sheds light on fundamental properties of thick and thin filament function in the human sarcomere and presents the first studies of HCM-causing mutants in a human background, it also establishes a new approach to the problem of cardiomyopathy that will be critical in truly understanding and targeting the disease.
- 2011Danielle Lurisa Leiske.The tear film is the thin layer of fluid that covers the surface of the eye. While the functions of the tear film are numerous, the primary role is to protect the corneal surface. When an individual has dry eye disease the tear film breaks up and exposes the corneal epithelial cells, which leads to ocular irritation. The primary components of the outermost layer of the tear film are meibomian lipids, a mixture of long chain nonpolar lipids. Although this lipid layer is thought to play an important role in tear film stability, little is known about the structure and viscoelasticity of meibum, or how these properties relate to tear film stability in dry eye disease. The primary focus of this work was to understand how meibum behaves at an air-water interface to mimic the in vivo conditions of the tear film lipid layer. At room temperature meibum was found to form a predominantly elastic interfacial film, although the film became more fluid as it was heated to body temperature. Interfacial x-ray scattering at room temperature revealed ordered lattices and multilayers at high levels of compression that contributed to high elasticity. In bulk samples, small angle x-ray scattering identified two populations of lipid lamellar phases with unique melt behavior. Meibum collected from patients with meibomian gland dysfunction, a form of dry eye disease, contained the same crystalline phases; however, the prevalence of those phases was reduced indicating a quantifiable change in lipid composition. To ascertain whether meibum viscoelastic properties are relevant to tear film performance, the effects of surface elasticity on an advancing droplet were studied. While droplets covered with a Newtonian monolayer followed classical hydrodynamics, meibum and other insoluble surfactants with surface shear elasticity induced periodic stick-release of the contact line at low advancing velocities and non-ideal behavior at higher velocities. Finally, to explore how a water soluble surfactant may be used to repair a compromised lipid layer, the interactions between a poly(ethylene oxide)-poly(butylene oxide) block copolymer (EOBO) and a model phospholipid monolayer were studied. The lipids and EOBO remained phase separated at the interface, yet EOBO was able to restore the native lattice spacing and mechanical properties of the lipid monolayer, which could make it a valuable tool for a number of biological applications. Meibomian lipids are a complex natural extract with a number of remarkable properties. Although the lipids present in meibum are diverse, meibum can form an elastic interfacial film with ordered phases in bulk material or at an interface. We have shown a link between meibum structure and elasticity, which both depend on temperature. Major composition changes that occur with disease could alter meibum melt temperature and viscoelasticity, which will ultimately modulate the ability of meibum to stabilize the tear film.
- 2009Deborah Lynn Burkhart.
- 2015 AccessMedicineeditors, Christopher Moriates, Vineet Arora, Neel Shah.The current state of healthcare costs and waste in the United States -- Medical coverage in the United States -- The challenges of understanding healthcare pricing -- Defining value : connecting quality and safety to the costs of care -- A changing landscape : cost consciousness and value in healthcare delivery -- Ethics of cost conscious care -- The importance of zip codes and genetic codes : variation in resource utilization -- Stents, robots, and the role of technology diffusion -- Primary care shortage crisis : lost opportunities to deliver value / David Margolius and Andrew Morris-Singer -- Barriers to providing high-value care / Daisy Smith and Steven Weinberger -- Building a pipeline for change : teaching about cost awareness and evidence-based medicine -- The role of patients : shared decision making, e-patients, and consumer directed healthcare -- High-value medication prescribing -- Screening and prevention : balancing benefits with harms and costs -- Shifting incentives : moving reimbursement from volume to value -- Implementing value-based initiatives : a new challenge for clinicians and healthcare systems.
- 2013 ClinicalKeyedited by Simon S. Cross ; illustrations and chapter icons by Robert Britton.What is pathology? -- What is disease? -- What causes disease? -- Disorders of growth, differentiation and morphogenesis -- Responses to cellular injury -- Disorders of metabolism and homeostasis -- Ischaemia, infarction and shock -- Immunology and immunopathology -- Inflammation -- Carcinogenesis and neoplasia -- Ageing and death -- How do pathologists help patient care? -- Cardiovascular system -- Respiratory tract -- Liver, biliary system and pancreas -- Endocrine system -- Breast -- Female genital tract -- Urinary and male genital tracts -- Kidney diseases -- Lymph nodes and extranodal lymphoid tissue, spleen and thymus -- Blood and bone marrow -- Skin -- Osteoarticular and connective tissues -- Central and peripheral nervous systems.
- 2012 CRCnetBASEYair Altman."Preface The Matlab programming environment uses Java for numerous tasks, including networking, data-processing algorithms, and graphical user-interface (GUI). Matlab's internal Java classes can often be easily accessed and used by Matlab users. Matlab also enables easy access to external Java functionality, either third-party or user-created. Using Java, we can extensively customize the Matlab environment and application GUI, enabling the creation of very esthetically pleasing applications. Unlike Matlab's interface with other programming languages, the internal Java classes and the Matlab-Java interface were never fully documented by The MathWorks (TMW), the company that manufactures the Matlab product. This is really quite unfortunate: Java is one of the most widely used programming languages, having many times as many programmers as Matlab. Using this huge pool of knowledge and components can significantly improve Matlab applications. As a consultant, I often hear clients claim that Matlab is a fine programming platform for prototyping, but is not suitable for real-world modern-looking applications. This book aimed at correcting this misconception. It shows how using Java can significantly improve Matlab program appearance and functionality and that this can be done easily and even without any prior Java knowledge. In fact, many basic programming requirements cannot be achieved (or are difficult) in pure Matlab, but are very easy in Java. As a simple example, maximizing and minimizing windows is not possible in pure Matlab, but is a trivial one-liner using the underlying Java codeʹ:"--Provided by publisher.
- 2015 SpringerGlenn L. Schattman, Sandro C. Esteves, Ashok Agarwal, editors.Part I: Definitions and Epidemiology -- Definitions and Relevance of Unexplained Infertility in Reproductive Medicine -- Definitions and Epidemiology of Unexplained Male Infertility -- Controversies Surrounding the 2010 World Health Organization Cutoff Values for Human Semen Characteristics and Its Impact on Unexplained Infertility -- Definitions and Epidemiology of Unexplained Female Infertility -- Part II: Pathophysiology: Male -- Sperm Biology from Production to Ejaculation -- Idiopathic Infertility: Survival and Function of Sperm in the Female Reproductive Tract -- Potential Male Etiologies of Unexplained Infertility -- Genetic Basis of Unexplained Male Infertility -- Role of the Immune System in Unexplained Male Infertility -- Oxidative Stress in Unexplained Male Infertility -- Role and Significance of Sperm Function in Men with Unexplained Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Male Infertility -- Part III: Pathophysiology: Female -- Potential Female Etiologies of Unexplained Infertility -- Oxidative Stress in Unexplained Female Infertility -- Role of Environmental Factors and Gonadotoxin Exposure in Unexplained Female Infertility -- Cervical Hostility and Vaginal pH in Females with Unexplained Infertility -- Role of Endometrial Receptivity in Unexplained Infertility -- Fallopian Tube Dysfunction in Unexplained Infertility -- Subtle Endometriosis and Unexplained Infertility -- Part IV: Evaluation -- Evaluation of Women with Unexplained Infertility -- Evaluation of Men with Unexplained Infertility -- Part V: Expectant, Medical and Surgical Treatment -- The Role of Expectant Management for Couples with Unexplained Infertility -- Treatment and Prognosis of Immunological Factors in Unexplained Male Infertility -- Medication Strategies for the Male with Unexplained Infertility -- Clomiphene Citrate for Women with Unexplained Infertility -- Aromatase Inhibitors in the Treatment of Unexplained Female Infertility -- Gonadotropins for Women with Unexplained Infertility -- Part VI: Assisted Reproductive Techniques and Future Perspectives -- Gonadotropin in Assisted Reproduction: An Evolution Perspective -- Intrauterine Insemination in Unexplained Female Infertility -- Role of In Vitro Fertilization in Unexplained Female Infertility -- Role of Assisted Reproduction Techniques in the Management of Unexplained Male Infertility -- Future Perspectives in the Diagnosis and Management of Unexplained Male Infertility.
- pt. A-C, 2011. ScienceDirectpt. B ScienceDirectpt. C ScienceDirectedited by P. Michael Conn.Also available: Print – pt. A-C, 2011.
- 2015 Springeredited by Michael T. Hirschmann, Roland Becker.Owing to improved understanding of biomechanics and tribology and advances in implant design and treatment technique, total knee arthroplasty (TKA) is considered a very successful treatment for osteoarthritic knees. Nevertheless, a significant minority of patients are unhappy with the outcome, complaining of pain, instability, swelling, or reduced range of motion. This book addresses the need for improved diagnostic and treatment guidelines for this challenging group of patients. The book opens by discussing the basics of TKA and the various causes of failure and pain. Diagnostic aspects are considered in detail, with attention to advances in clinical investigation, laboratory analysis, and, in particular, imaging techniques. Furthermore, state of the art diagnostic algorithms are presented that will assist in identifying the source of the problem in individual cases. Specific pathology-related treatment options, including conservative approaches and salvage and revision TKA strategies, are then explained, with identification of the pitfalls and key points of each treatment. Future perspectives are briefly considered, and a series of cases are presented that cover clinical scenarios frequently encountered in daily clinical practice. The evidence-based, clinically focused guidance provided in this book, written by internationally renowned experts, will assist surgeons in ensuring that patients with an unsatisfactory result of TKA receive the most effective management. The book will also be helpful for general practitioners, physiotherapists, industry technicians, and engineers.
- 2005 ProQuest SafariJames Rumbaugh, Ivar Jacobson, Grady Booch.
- Uniform requirements for manuscripts submitted to biomedical journals : and supplemental statements from the International Committee of Medical Journal Editors.2004Covers guidelines for the format of manuscripts submitted to biomedical journals. In addition, discusses retraction of research findings, order of authorship, definition of a peer-reviewed journal, and conflict of interest. Each statement was initially published in a scientific journal and citations to the original publications are included.Also available: Print – 1994-
- Also available: Print – 2002
- 2008 Springeredited by Shahid Rahman, Tony Street, Hassan Tahiri.
- Wendy Chisholm and Matt May.
- 2006 Springeredited by Mordechai Feingold and Victor Navarro-Brotons."Mathematics for astronomy" at universities in Copernicus' time / Grazina Rosińska -- The University of Salamanca and the renaissance of astronomy during the second half of the 15th century / José Chabás -- Medical science and medical teachings at the University of Salamanca in the 15th century / Luis García Ballester -- The faculty of medicine of Valencia / José M. López Piñero -- The cultivation of astronomy in Spanish universities in the latter half of the 16th century / Victor Navarro-Brotons -- The Sphere of Jacques du Chevreul: astronomy at the University of Paris in the 1620s / Roger Ariew -- Lectures and practices: the variety of mathematical and mechanical teaching at the University of Uppsala in the 17th century / Maija Kallinen -- Mathematical research in Italian universities in the modern era / Maria Teresa Borgato -- Universities, academies, and sciences in the modern age / Luigi Pepe -- Natural philosophy and mathematics in Portuguese universities, 1550-1650 / Luís Miguel Carolino & Henrique Leitão -- Venetian policy toward the University of Padua and scientific progress during the 18th century / Piero del Negro -- Candide in Caledonia: the culture of science in the Scottish universities, 1690-1805 / Paul Wood -- The sciences at the University of Rome in the 18th century / Ugo Baldini -- Enlightenment and renovation in the Spanish university / José Luis Peset -- Spanish chemistry textbooks during late 18th century / Antonio García Belmar and José Ramón Bertomeu Sánchez -- Botany in University studies in the late 18th century : the case of Valencia University / Cristina Sendra-Mocholí -- Scientific education and the crisis of the university in 18th century Barcelona / Agustí Nieto-Galan & Antoni Roca-Rosell -- The theories of Copernicus and Newton in the Viceroyship of Nueva Granada and the Audiencia de Caracas during the 18th century / Luis Carlos Arboleda Aparicio & Diana Soto Arango.
- University Department of Psychiatry in Munich : from Kraepelin and his predecessors to molecular psychiatry2008 Springerby Hanns Hippius, Hans-Jürgen Möller, Norbet Müller, Gabriele Neundörfer-Kohl.Early Psychiatric Institutions in Munich -- Psychiatric Care in Bavaria in the 19th Century -- The Chair for Psychiatry at the Medical Faculty of the University of Munich -- Bernhard von Gudden, Doctor and Founder of Modern Neuromorphology -- Planning and Construction of the Royal Psychiatric University Hospital in the Nussbaumstrasse -- The Opening of the Psychiatric Hospital in 1904 by Emil Kraepelin -- The Munich Hospital Managed by Emil Kraepelin -- The Idea and Planning of the German Psychiatric Research Institute -- Oswald Bumke and his Munich Workgroup -- The Post War Period and Beginning of the Hospital's Reconstruction under Georg Stertz -- Kurt Kolle and Plans for a New Hospital Building in Grosshadern -- Division of the "Hospital for Nervous Diseases" into a Psychiatric Hospital in the Inner City and a Neurological Hospital in Grosshadern -- The Psychiatric Hospital since 1994 -- The Psychiatric Hospital 1971-1994 -- The Re-Opening of the Historical Old Building -- Scientific publications since 2000.
- University Department of Psychiatry in Munich : from Kraepelin and his predecessors to molecular psychiatry2008 Springerby Hanns Hippius ... [et al.].
- 2006 ProQuest SafariSU Catalog (SearchWorks) Click LINK above for Print location/circulation status.Arnold Robbins.Introduction -- Unix commands -- The Unix shell: an overview -- The Bash and Korn shells -- tcsh: an extended C shell -- Package management -- Pattern matching -- The Emacs editor -- The vi, ex, and vim editors -- The sed editor -- The awk programming language -- Source code management: an overview -- The revision control system -- The concurrent versions system -- The subversion version control system -- The GNU make utility -- The GDB debugger -- Writing manual pages.
- 2013Paola Bergallo.Demands for the protection of social rights, and health rights in particular, have become a distinctive feature of judicialization in Latin American countries, including Argentina. Although a growing number of studies have begun to document the new relationship between the courts and health rights generated after almost two decades of litigation, little is yet empirically known about the versatile struggles undertaken in domestic courts and their consequences beyond the judgments. More specifically, given the scarcity of domestic empirical explorations, much remains to be discovered about legal mobilization experiences and courts' roles in the adjudication of conflicts regarding the intersection of health policies and rights. This dissertation takes a step toward filling that gap by exploring a set of conceptual, theoretical, and methodological questions that are critical to advancing current debates on health and the role of courts in bringing justice and expanding the rule of law in Argentina. With that aim in mind, this dissertation proceeds in two stages. First, it offers a basic assessment of the context and magnitude of the judicialization of health in the country, relying on multiple secondary sources and descriptive statistics obtained from databases of court decisions and dockets generated for this dissertation. Second, to complement the broader picture, the project proposes a qualitative study of strands of health rights litigation, offering a process-based observation of diverse patterns of judicialization while helping identify and compare the broader impacts of courts' roles in adjudicating health rights demands. Through these narrative studies, this dissertation tells the story of how once-dormant health rights clauses have come to life through the work of litigants, judges, and policy makers. It also shows how, in the process of unleashing health rights, courts have played contradictory roles throughout the nonlinear trajectories of different patterns of judicialization that can be located along a spectrum in which an atomistic and routinized style of judicialization is at one extreme, a bureaucratizing form of judicialization is in the middle, and a cooperative style of judicialization is at the other extreme. Ultimately, throughout these rich and variegated experiences of judicialization, courts' adjudication of right-to-health claims has sometimes reinforced ineffective or unequal arrangements, while at other times exhibiting potentially transformative capacities.
- 2015J. David Hawkins, Jeffrey M. Jenson, Richard Catalano, Mark W. Fraser, Gilbert J. Botvin, Valerie Shapiro, C. Hendricks Brown, William Beardslee, David Brent, Laurel K. Leslie, Mary Jane Rotheram-Borus, Pat Shea, Andy Shih, Elizabeth Anthony, Kevin P. Haggerty, Kimberly Bender, Deborah Gorman-Smith, Erin Casey, and Susan Stone.Every day across America, behavioral health problems in childhood and adolescence, from anxiety to violence, take a heavy toll on millions of lives. For decades the approach to these problems has been to treat them only after they've been identified--at a high and ongoing cost to young people, families, entire communities, and our nation. Now we have a 30-year body of research and more than 50 programs showing that behavioral health problems can be prevented. This critical mass of prevention science is converging with growing interest in prevention across health care, education, child psychiatry, child welfare, and juvenile justice. Together, we stand at the threshold of a new age of prevention. The challenge now is to mobilize across disciplines and communities to unleash the power of prevention on a nationwide scale. Proposes a grand challenge that will advance the policies, programs, funding, and workforce preparation needed to promote behavioral health and prevent behavioral health problems among all young people--including those at greatest disadvantage or risk, from birth through age 24. Within a decade, we can reduce the incidence and prevalence of behavioral health problems in this population by 20 percent from current levels through widespread policies and programs that will serve millions and save billions. Prevention is the best investment we can make, and the time to make it is now.
- 2014Georg Northoff.V. 1. Coding -- v. 2. Consciousness.
- 2012 Springer Protocolsedited by Loredano Pollegioni, Stefano Servi.Preparation of unnatural amino acids with ammonia-lyases and 2,3-aminomutases / László Poppe [and others] -- Multistep enzyme catalyzed reactions for unnatural amino acids / Paola D'Arrigo and Davide Tessaro -- Enzymatic production of enantiopure amino acids from mono-substituted hydantoin substrates / Gwynneth F. Matcher, Rosemary A. Dorrington, and Stephanie G. Burton -- Preparation of glutamate analogues by enzymatic transamination / Thierry Gefflaut, Zeinab Assaf, and Martine Sancelme -- Carbon-carbon bond-formng enzymes for the synthesis of non-natural amino acids / Pere Clapés, Jesús Joglar, and Mariana Gutiérrez -- Engineering cyclic amidases for non-natural amino acid synthesis / Francisco Javier Las Heras-Vázquez [and others] -- NMR analysis of unnatural amino acids in natural antibiotics / Franca Castiglione -- Site-specific incorporation of unnatural amino acids as probes for protein conformational changes / Jennifer C. Peeler and Ryan A. Mehl -- Application of unnatural amino acids to the de novo design of selective antibiotic peptides / Rickey P. Hicks and Amanda L. Russell -- Use of unnatural amino acids to probe structure-activity relationships and mode-of-action of antimicrobial peptides / Alessandro Tossi [and others] -- Experimental methods for scanning unnatural amino acid mutagenesis / Jia Liu and T. Ashton Cropp -- Genetic incorporation of unnatural amino acids into proteins in yeast / Qian Wang and Lei Wang -- Site-specific incorporation of unnatural amino acids into proteins in mammalian cells / Nobumasa Hino, Kensaku Sakamoto, and Shigeyuki Yokoyama -- Incorporation of unnatural non-[alpha]-amino acids into the N-terminus of proteins in a cell-free translation system / Takahiro Hohsaka -- Site-specific modification of proteins by the Staudinger-phosphite reaction / Paul Majkut [and others] -- HPLC methods for determination of D-aspartate and N-methyl-D-aspartate / George H. Fisher and Mara Tsesarskaia -- Estimation of chronological age from the racemization rate of L- and D-aspartic acid : how to completely separate enantiomers from dentin / Toshiharu Yamamoto and Susumu Ohtani -- Enzymatic detection of D-amino acids / Gianluca Molla [and others] -- An enzymatic-HPLC assay to monitor endogenous D-serine release from neuronal cultures / Inna Radzishevsky and Herman Wolosker -- Electrophysiological analysis of the modulation of NMDA-receptors function by D-serine and glycine in the central nervous system / Fabrice Turpin, Glenn Dallérac, and Jean-Pierre Mothet -- Biosensors for D-amino acid detection / Silvia Sacchi [and others] -- Analysis of D-[beta]-aspartyl isomers at specific sites in proteins / Noriko Fujii and Horihiko Fujii -- Nutritional value of D-amino acids, D-peptides, and amino acid derivatives in mice / Mendel Friedman and Carol E. Levin -- Preparation and assay of recombinant serine racemase / Florian Baumgart, Clara Aicart-Ramos, and Ignacio Rodriguez-Crespo -- Assay of amino acid racemases / Masumi Katane, Masae Sekine, and Hiroshi Homma -- Assays of D-amino acid oxidases / Gabriella Tedeschi, Loredano Pollegioni, and Armando Negri -- Enzymes acting on D-amino acid containing peptides / Yasuhisa Asano.
- 2013Philip Lieberman."The Unpredictable Species argues that the human brain evolved in a way that enhances our cognitive flexibility and capacity for innovation and imitation. In doing so, the book challenges the central claim of evolutionary psychology that we are locked into predictable patterns of behavior that were fixed by genes, and refutes the claim that language is innate. Philip Lieberman builds his case with evidence from neuroscience, genetics, and physical anthropology, showing how our basal ganglia--structures deep within the brain whose origins predate the dinosaurs--came to play a key role in human creativity. He demonstrates how the transfer of information in these structures was enhanced by genetic mutation and evolution, giving rise to supercharged neural circuits linking activity in different parts of the brain. Human invention, expressed in different epochs and locales in the form of stone tools, digital computers, new art forms, complex civilizations--even the latest fashions--stems from these supercharged circuits." -- [Publisher-supplied data]
- 2013Alexis Jane Battle.Recent technological advances have allowed us to collect genomic data on an unprecedented scale, with the promise of revealing genetic variants, genes, and pathways disrupted in clinically relevant human traits. However, identifying functional variants and ultimately unraveling the genetics of complex disease from such data have presented significant challenges. With millions of genetic factors to consider, spurious associations and lack of statistical power are major hurdles. Further, we cannot easily assess functional roles even for known trait-associated variants, particularly for those that lie outside of protein-coding regions of the genome. To address these challenges in identifying the genetic factors underlying complex traits, we have developed probabilistic machine learning methods that leverage biological structure and prior knowledge. In this thesis, we describe four applications of such models. First, we present a method for reconstructing causal gene networks from interventional genetic interaction data in model organisms. Here, we are able to identify intricate functional dependencies among hundreds of genes affecting a complex trait. We have applied this method to understanding the genetics of protein folding in yeast, where we demonstrate ability to recapitulate the details, including ordering, of known pathways, and make novel functional predictions. Second, we present PriorNet, a method for incorporating gene network and path- way information into the analysis of population-level studies of genetic variation in human disease. PriorNet utilizes a flexible, Markov Random Field prior to propagate information between functionally related genes and related diseases, in order to improve statistical power in large-scale disease studies. We demonstrate a significant improvement in the discovery of disease-relevant genes in studies of three autoimmune diseases. Next, we extend the intuitions of PriorNet in a method for identifying interactions between genetic variants in human disease, to begin to understand how genes work together in complex disease processes. Our method, GAIT, leverages gene networks, network structure, and other patterns to adaptively prioritize candidate in- teractions for testing, and dramatically reduce the burden of multiple hypothesis correction to identify a large number of interactions in diverse human disease studies. Finally, we discuss the identification of functional variants on a large scale through the use of gene expression as a high-resolution cellular phenotype. We have sequenced RNA from 922 genotyped individuals to provide a direct window into the distribution, properties, and consequences of thousands of regulatory variants affecting diverse gene expression traits including splicing and allelic expression. From the identified variants, we also train a model, LRVM, for predicting regulatory consequences based on location and genomic properties of each variant.
- 2014Shafiqul Alam Kiron ; concept and text, Monira Rahman [and three others].
- 2013 SpringerLucy W. Barrett, Sue Fletcher, Steve D. Wilton.There is now compelling evidence that the complexity of higher organisms correlates with the relative amount of non-coding RNA rather than the number of protein-coding genes. Previously dismissed as ""junk DNA"", it is the non-coding regions of the genome that are responsible for regulation, facilitating complex temporal and spatial gene expression through the combinatorial effect of numerous mechanisms and interactions working together to fine-tune gene expression. The major regions involved in regulation of a particular gene are the 5' and 3' untranslated regions and introns.
- 2011 SpringerO.S. Miettinen.Pt. 1. Philosophical propedeutics -- pt. 2. Theory of clinical medicine -- pt. 3. Theory of clinical research -- pt. 4. Contemporary realities in clinical research -- pt. 5. Epilogue on major improvements in clinical medicine -- pt. 6. Appendices.
- 2013 SpringerAntonella Tosti, Doris Hexsel, editors.This well-illustrated guide provides concise descriptions of the most frequently encountered cosmetic skin conditions and essential information on commonly employed treatment procedures. The book opens with a description of skin evaluation systems and then documents etiology, pathogenesis, diagnosis, and treatment for various conditions, including cellulite, acne, hirsutism, and striae distensae. The second part of the book provides step-by-step guidelines on a range of cosmetic procedures, such as botulinum toxin injection, cryosurgery, electrosurgery, and injection lipolysis. The advice provided will be invaluable for all physicians who intend to incorporate these procedures into their practices. The book will also be of interest to established specialists in cosmetic dermatology wishing to update their knowledge and to all general dermatologists and plastic surgeons required to answer the numerous questions posed by patients seeking to maintain or improve the quality of their skin.
- 2006 HighWireedited by Jean-Pierre Bassand.
- 2008guest editors: Marin H. Kollef ...
- 2005 Springeredited by David C. Chhieng and Gene P. Siegal.Surgical pathology of the parathyroid glands / Walter C. Bell -- Uncommon and relatively uncommon lesions of the female reproductive system / Michael G. Conner -- Who is who among urothelial neoplasms? / Katrin M. Klemm -- Diverticular colitis / Audrey J. Lazenby -- Molecular markers in breast cancer: current practice and future possibilities / Thomas Winokur -- Cytology and surgical pathology of the mediastinum / Claudia Y. Castro and David C. Chhieng -- Cytology and surgical pathology of pleural cavities / Claudia Y. Castro and David C. Chhieng -- Cytology and surgical pathology of neoplasms of the lung / Claudia Y. Castro and David C. Chhieng -- Endoscopic ultrasound guided fine needle aspiration of the pancreas / Darshana Jhala and Nirag C. Jhala -- Using imaging data in making orthopedic diagnoses / Michael J. Klein -- Selected case studies in hematopathology: application of current ancillary techniques in diagnosis / Vishnu V. Reddy -- Aggressive B-cell lymphomas / Wei Yang and Catherine M. Listinsky -- Demystifying the diagnosis of gliomas / Cheryl Ann Palmer -- Odontogenic tumors for general pathologists / Nasser Said-Al-Naief -- Effective communication of antimicrobial susceptibility data by pathologists to clinicians / Ken B. Waite -- Acquisition and use of digital images for pathology education and practice / Kristina T.C. Panizzi, Kristopher N. Jones, and Peter G. Anderson.Also available: Print – 2005
- 2014 SpringerBrendon J. Coventry, editor.Written by internationally acclaimed specialists,"Upper Abdominal Surgery" provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. The text is illustrated with photographs that depict anatomic or technical principles.
- 2015 SpringerShahrokh F. Shariat, Evanguelos Xylinas, editors.Upper Tract Urothelial Carcinoma represents the first book of its kind to be dedicated solely to UTUC. Its aim is to improve understanding and eventually care of a disease that is greatly understudied and underappreciated, yet commonly dealt with by many medical and urologic oncologists. The volume features new data regarding genetic susceptibility, gene expression studies and causative factors; contemporary concepts and controversies regarding diagnosis and staging of UTUC; prediction tools and their value in treatment decisions within each disease stage andpatient selection and treatment options such as endoscopic management, distal ureterectomy, radical nephroureterectomy and chemotherapy. Up-to-date information regarding boundaries of surgical resection, indication and extent of lymphadenectomy are covered as well as the role of perioperative/neoadjuvant chemotherapy in patients with high-risk UTUC. Upper Tract Urothelial Carcinoma will be of great value to all Urologists, Medical Oncologists, and fellows in Urologic Oncology as well as upper level residents in training in Urology and Medical Oncology.
- 2015 SpringerMichael Grasso III, Demetrius H. Bagley, editors.Upper tract urothelial carcinoma : ureteroscopic biopsy and specimen preparation / Demetrius H. Bagley, Ryuta Tanimoto, and Kelly A. Healy -- Imaging of upper tract transitional cell carcinoma / Sarah L. Steenbergen and Gary Israel -- Cytopathology and management of ureteroscopic biopsy samples / Shuye Ren and Marluce Bibbo -- Ureteroscopic treatment of upper urinary tract urothelial malignancy / Michael Grasso III, Bobby S. Alexander, Lynn J. Paik, and Andrew I. Fishman -- Surgical management of upper tract urothelial carcinoma- open, laparoscopic, and robotic approaches to nephroureterectomy and outcomes / Marc J. Mann, Costas D. Lallas, and Edouard J. Trabulsi -- Surveillance after treatment for upper tract transitional cell carcinoma / Michael J. Conlin and Brian D. Duty -- Topical chemotherapy / John Michael Henderson and Francis X. Keeley Jr. -- Systemic chemotherapy for upper tract urothelial cancer / Jean Hoffman-Censits -- Hereditary upper tract urothelial carcinoma : Lynch syndrome, hereditary nonpolyposis colorectal cancer syndrome (HNPCC) / Scott G. Hubosky and Bruce M. Boman -- Bladder tumors : association with upper tract neoplasms / Christopher B. Anderson, John E. Musser, John P. Sfakianos, and Harry W. Herr -- Enhanced imaging : NBI, PDD, SPIES / Luca Villa, Jonathan Cloutier, and Olivier Traxer -- Beyond endoscopy- ultrasound, optical coherence tomography and confocal laser endomicroscopy / Mieke T.J. Bus, Daniel Martin de Bruin, Guido M. Kamphuis, Theo M. de Reijke, and Jean J.M.C.H de la Rosette -- Diagnostic and treatment algorithm of upper tract urothelial carcinoma / Andrew I. Fishman, Lynn J. Paik, and Michael Grasso III.
- Mobile Application, UpToDate for iOS Users must register through the campus network, download the app, and sign in.Rose, Burton David.UpToDate is a web-based, clinical information resource, designed to provide concise, practical answers to clinical questions. The content is updated quarterly. Nearly 3,000 author physicians continually review the literature for material that is well supported by data and would be useful in a clinical setting. If a medical finding is deemed important, it is then added to the relevant topic review(s) after approval by an internal peer review and by the authors. The content is comprehensive, concise, and fully referenced.
- 2015RAND Corporation, Lisa M. Sontag-Padilla, Rachel M. Burns, Regina A. Shih, Beth Ann Griffin, Laurie T. Martin, Anita Chandra ; University of Tennessee Health Science Center, Frances Tylavsky.Machine generated contents note: ch. One Introduction -- The Importance of Examining Early-Childhood Cognitive and Behavioral Development -- The Urban Child Institute and the History of the CANDLE Study -- Purpose of This Report -- Structure of the Report -- ch. Two Study Design and Methods -- Study Design -- Eligibility -- Recruitment -- Data Collection -- Study Population -- Analytic Sample and Attrition over Time -- Approach to Weighting the CANDLE Sample -- Sample Characteristics -- Sample Characteristics Used for Weighting (Age, Race, Education, Income) -- Other Demographic Characteristics of the Mothers in the Sample -- Demographic Characteristics of the Child's Father -- Measures -- ch. Three Prenatal and Birth Measures -- Maternal Baseline Enrollment Data Form -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Labor and Delivery Form -- Background -- Description -- Administration -- Scoring -- Data -- Neonatal Summary Form -- Background -- Description -- Administration -- Data -- ch. Four Child and Family Health -- Child Health Update Form -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Sleep Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Family Health History -- Background -- Description -- Administration -- Data Notes -- Data -- Residence Establishment and Lead Risk Assessment -- Background -- Description -- Administration -- Data Notes -- Data -- Child Exam -- Background -- Description -- Administration -- Data Notes -- Data -- Children with Special Health Care Needs Screener -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Five Child and Family Nutrition -- Block Food Frequency Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Choline Inhibitor Questionnaire -- Background -- Description -- Administration -- Data Notes -- Infant Feeding Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Food Supplement Information -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Six Mother's Mental and Behavioral Health -- Temperament Evaluation of Memphis, Pisa, Paris, and San Diego -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- Brief Symptom Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Rosenberg Self-Esteem Scale -- Background -- Description -- Administration -- Data Notes -- Data -- Edinburgh Postnatal Depression Scale -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Seven Cognitive Performance -- Bayley Scales of Infant Development -- Background -- Description -- Administration -- Data Notes -- Data -- Wechsler Abbreviated Scale of Intelligence -- Background -- Description -- Administration -- Data Notes -- Data -- ch. Eight Psychosocial Measures -- Conflict Tactics Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Traumatic Life Events Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Social Support Questionnaire, 6th Edition -- Background -- Description -- Administration -- Data Notes -- Data -- Knowledge of Infant Development Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Household Questionnaire -- Background -- Description -- Administration -- Data Notes -- Data -- Child Abuse Potential Inventory -- Background -- Description -- Administration -- Data Notes -- Data -- Parenting Stress Index Short Form -- Background -- Description -- Administration -- Data Notes -- Data -- Parent-Child Interaction Nursing Child Assessment Satellite Training Teaching Scales -- Background -- Description -- Administration -- Data Notes -- Data -- Child Care Information -- Background -- Description -- Administration -- Data Notes -- Data -- Scales of Independent Behavior -- Revised -- Background -- Description -- Administration -- Data Notes -- Data -- Brief Infant Toddler Social Emotional Assessment -- Background -- Description -- Administration -- Scoring -- Data Notes -- Data -- ch. Nine Implications and Potential Benefits for the CANDLE Study -- Appendix. Biological Samples -- Biologic Measures -- Biological Lead Substudy.
- 2014 SpringerBaoxue Yang, Jeff M. Sands, editors.The mechanisms and physiological functions of urea transport across biological membranes are subjects of long-standing interest. Recent advances in the molecular biology and physiology of urea transport have yielded new insights into how and why urea moves across cell membranes. In the last two decades, seven facilitated urea transporters (UT-A1-6 and UT-B) have been cloned, and their gene organization, protein crystal structure, expression localization and physiological functions in the tissues have been described. In recent years, the studies in urea transporter knockout mouse models suggest that urea transporters may be useful targets for drug discovery of selective inhibitors. The modulation of urea transport activity by pharmacological agents may provide novel treatments for hypertension, congestive heart failure and other fluid-retaining states. However, although urea represents about 40% of all urinary solutes in normal human urine, the handling of this solute in the tissues has been largely neglected in the past, and few clinical or experimental studies now report data about urea. Most recent physiological textbooks include chapters on water and electrolyte physiology but not a single chapter on urea. Our aim in writing this book is to stimulate further research in new directions by providing novel and provocative insights into further mechanisms and the physiological significance of urea metabolism and transport in mammals. The book provides a state-of-the-art report on the latest findings on urea transport and where the field is going. Although some older work is cited, the main focus is on advances made over the past 20 years with regard to the biophysics, genetics, protein structure, molecular biology, physiology, pathophysiology and pharmacology of urea transport in mammalian cell membranes. These aspects are especially valid, as advances in our understanding of urea transporting mechanisms and physiology promise to yield new insights into biology and medicine.
- 2015 SpringerSutchin R. Patel, Stephen Y. Nakada.Providing a complete updated roadmap to treating ureteral stones, Ureteral Stone Management: A Practical Approach presents newer topics focusing of the recent improvements in instrumentation and adjunctive equipments, managing radiation to both patient and urologist, as well as reviews of the most recent studies on urologic practices. Ureteral Stone Management: A Practical Approach assists the reader in a logical and step wise pathway for selecting the best treatment options and how to work through complications. This evidence-based text is valuable to all those working in the field of urology.
- 2010 SpringerSaverio Pagano ; con la collaborazione di Paolo Rovellini e Pantaleo Ruggeri ; presentazione a cura di Giuseppe Martorana.
- 2013 SpringerManoj Monga, editor.Ureteroscopy: Indications, Instrumentation & Technique provides a comprehensive and state-of-the-art review of ureteroscopy and will serve as a valuable resource for urologists throughout the world. The volume provides evidence based outcomes to support the expanding indications for ureteroscopy as well as a strong emphasis on appropriate patient selection. The book also provides detailed recommendations for the step-by-step approach to ureteroscopy from both an instrumentation and techniques perspective. The work is extensively illustrated with endoscopic images and includes a DVD of video clips which further highlight the clinical application of available endoscopic techniques. The text also includes highly practical presentations of complex endourologic case presentations with expert analysis and editorial commentary. Example cases would include common but challenging cases of ureteroscopy for transitional cell cancer, horseshoe kidneys, hutch diverticulum, and pregnancy. Ureteroscopy: Indications, Instrumentation & Technique provides a unique and valuable resource in the field of ureteroscopy and will include basic instructions for those currently in training or those who have yet to adapt intrarenal ureteroscopy into their surgical armamentarium. Advanced ureteroscopic approaches are also covered for those wishing to enrich their current clinical expertise.
- 2006 Springer[edited by] F. Schreiter and G.H. Jordan.1. Introduction / F. Schreiter, G.H. Jordan -- 2. Historical highlights in the development of urethral surgery / K. Bandhauer -- 3. Anatomy and blood supply of the urethra and penis / J.K.M. Quartey -- 4. Fundamentals and principles of tissue transfer / G.H. Jordan, K. Rourke -- 5. Tissue engineering: the future of urethral reconstructive surgery? / K.D. Sievert -- 6. Hypospadia repair: the past and the present - also the future? / R. Hohenfellner -- 7. Urethral reconstruction in women / E.J. McGuire -- 8. A Current overview of the treatment of urethral strictures: etiology, epidemiology, pathophysiology, classification, and principles of repair / S.M. Schlossberg -- 9. The Acute posterior urethral injury / J. Latini, J.T. Stoffel, L. Zinman -- 10. The endoscopic treatment of post-traumatic membranous urethral strictures / V. Pansadoro, P. Emiliozzi -- 11. Endoscopic realignment of post-traumatic membranous urethral disruption / V. Pansadoro, P. Emiliozzi -- 12. The Role of bouginage, visual urethrotomy, and stents today / H. Sperling, M. Goepel, H. Rübben -- 13. Alternative endourological techniques in the treatment of urethral strictures: review of the current literature / E. Geist, R. Hartung -- 14. Reconstruction of the bulbar and membranous urethra / F. Schreiter, B. Schönberger, R Olianas -- 15. The Sagittal posterior (transcoccygeal transrectal transsphincteric) approach for reconstruction of the posterior urethra / D. Streit -- 16. The Use of flaps in urethral reconstructive surgery / G.H. Jordan, K.F. Rourke -- 17. Reconstruction of the fossa navicularis / G.H. Jordan, K.F. Rourke -- 18. Penile circular fasciocutaneous flaps for complex anterior urethral strictures / K.J. Carney, J.W. McAninch -- 19. Selective use of the perineal artery fasciocutaneous flap (Singapore) in urethral reconstruction / L. Zinman -- 20. Anterior urethral stricture repair and reconstruction in hypospadias cripples / F. Schreiter, B. Schönberger -- 21. The Use of free grafts for urethroplasty / D.E. Andrich, A.R. Mundy -- 22. Repair of bulbar urethra using the Barbagli technique / G. Barbagli, M. Lazzeri -- 23. Indications and limitations of buccal mucosa reconstructive urethral surgery in hypospadias repair / M. Fisch -- 24. Indications and limits for the use of boccal mucosa for urethral reconstruction / D. Kröpfl, A. Verweyen -- 25. Two-stage mesh-graft urethroplasty / F. Schreiter.
- 2008 Springeredited by Steven B. Brandes.
- 2009 Springersous la direction de Jean-Paul Beregi ; avec la collaboration des membres de la SFICV.
- 2008Susan King Strasinger, Marjorie Schaub Di Lorenzo.
- 2016 SpringerSanjay Razdan.Anatomic Foundations and Pathophysiology of Urinary Continence -- Preoperative Assessment and Intervention:Optimizing Outcomes for Early Return of Urinary Continence -- Preoperative Assessment and Intervetion: Optimizing Outcomes for Early Return of Erectile Function -- Pathophysiology of Nerve Injury and Its Effect on Return of Erectile Function -- Technical Innovations to Optimize Early Return of Urinary Continence -- Technical Innovations to Optimize Early Return of Erectile Function -- Oncologic Outcomes of Robotic Radical Prostatectomy: The "Balancing Act" of Achieving Cancer Control and Minimizing Collateral Damage -- Adjunctive Measures to Optimize Early Return of Urinary Continence -- Adjunctive Measures and New Therapies to Optimize Early Return of Erectile Function.
- 2016 SpringerJaspreet S. Sandhu, editor.1. Introduction: urinary function alterations in men with prostate cancer -- 2. Post-prostatectomy incontinence initial evaluation -- 3. Urinary incontinence: conservative and medical management and injectable therapy -- 4. Urinary dysfunction in prostate cancer: male slings -- 5. Artificial urinary sphincter: patient selection and surgical technique -- 6. Troubleshooting and optimizing outcomes after artificial urinary sphincter -- 7. Management of vesicourethral anastomotic stricture -- 8. Rectourethral fistula -- 9. Reoperative anti-incontinence surgery -- 10. Post-RT urinary incontinence and stricture -- 11. A case-based illustration of urinary symptoms following radiation therapy for prostate cancer -- Index.
- 2007 Springeredited by Marshall L. Stoller, Maxwell V. Meng.
- 2011 SpringerKarl-Erik Andersson, Martin C. Michel, editors.The basic anatomy and physiology of the urinary tract, the validity of animal models and other methodological considerations as well as a range of potential therapeutic targets are comprehensively reviewed by leading international experts, making this a unique reference source for basic scientists and research-minded clinicians alike.
- 2012 SpringerDonna E. Hansel, Jesse K. McKenney, Andrew J. Stephenson, Sam S. Chang, editors.Providing a true integration of pathology with clinical management, this volume presents a practical, comprehensive text on benign and malignant disease of the adult bladder. Integrating pathology, surgical management, oncology and molecular study in a site-specific manner to include the urethra, urinary bladder, ureter and renal pelvis, The Urinary Tract: A Comprehensive Guide to Patient Diagnosis and Management is the first text in adult bladder disease to closely interweave multiple clinical disciplines into each chapter. For the majority of chapters, a pathologist and urologist or urologic oncologist are paired to provide the greatest integration of information for each disease process.
- 2013 SpringerAbhay Rané, Ranan Dasgupta, editors.The causative organisms of Urinary Tract Infection are dynamic in terms of their virulence and resistance patterns, leading to challenges in the prevention and treatment of urinary infection. This is of relevance in both primary and secondary care, and many of the challenges are similar in both developed and developing countries alike. UTI is also associated with considerable cost in terms of morbidity, economic and research expenditure. Written by an exceptional and well-known team of clinical experts, the purpose of Urinary Tract Infections addresses key questions facing physicians about this condition. This book is written primarily for general physicians who wish to have a broad understanding of a number of important issues concerning infection in parts of the urinary tract. Specialists may also find the book useful as a quick reference guide.
- 2011 SpringerNagaraja P. Rao, Glenn M. Preminger, John P. Kavanagh, editors.This book constitutes more than a quarter of urologists, workload in the Western countries and is more than half in the Middle-East and Central Asian countries. The surgical management of stone disease has changed considerably in the last five years and our understanding of mechanism of stone disease has improved with some old concepts discarded and newer theories gaining ground. Covering the entire spectrum of urinary stone disease and with contributions of more than fifty internationally recognised experts, this exhaustive and complex reference work will be invaluable to all urologists, nephrologists and non-medical scientists.
- 2015 SpringerYouhe Gao, editor.This book systematically summarizes the ideas and technologies used in urine proteome analysis. It argues that change is the core of biomarker definition since the body uses its homeostatic mechanisms to correct changes in the blood. This means that urine is probably a better source of biomarkers than blood. A roadmap to the urinary biomarker era is proposed, and researchers are reminded of the potential opportunities and risks in their study design. Kidney diseases are emphasized as they produce the most significant changes in urine. This book tries to show researchers and graduate students, who are in or entering the field, "all things considered" rather than "the current affair".
- 2006 SpringerPaul Abrams.
- 2008 Thieme BookBernd Hamm [and others] ; [translator, Bettina Herwig].
- 2013 SpringerKate H. Moore.Taking the history -- Physical examination -- How to manage the patient after history and examination -- How to conduct urodynamic studies: essentials of a good urodynamic report -- Outcome measures used to assess response -- Conservative therapy of urodynamic stress incontinence -- Step-by-step guide to treatment of overactive bladder (OAB)/Detrusor overactivity -- Anal incontinence and disorders of obstructive defecation -- Surgery for urodynamic stress incontinence -- Management of prolapse -- Recurrent bacterial cystitis in women -- Interstitial cystitis.
- 2015 ClinicalKey[edited by] Mark D. Walters, Mickey M. Karram.Historical milestones in female pelvic surgery, gynecology, and female urology -- Anatomy of the lower urinary tract, pelvic floor, and rectum -- Embryology and congenital anomalies of the urinary tract, rectum, and female genital system -- Neurophysiology and pharmacology of the lower urinary tract -- Physiology of the pelvic muscles, vagina, and anorectum -- Female sexual function and dysfunction : assessment and treatment -- Epidemiology and psychosocial impact of female pelvic floor disorders -- Description and classification of lower urinary tract dysfunction and pelvic organ prolapse -- Evaluation of urinary incontinence and pelvic organ prolapse : history, physical examination, and office tests -- Urodynamics : indications, techniques, interpretation, and clinical utility -- Video and ambulatory urodynamics -- Endoscopic evaluation of the lower urinary tract -- Radiologic studies of the lower urinary tract and pelvic floor -- Neurophysiologic testing for pelvic floor disorders -- Pathophysiology of urinary incontinence -- Obstetrics and pelvic floor disorders -- Stress urinary incontinence and pelvic organ prolapse : nonsurgical management -- Retropubic operations for stress urinary incontinence -- Biologic bladder neck sling for stress urinary incontinence -- Synthetic midurethral slings for stress urinary incontinence -- Laparoscopic and robotic surgery for pelvic organ prolapse and stress urinary incontinence -- Urethral injection of bulking agents for intrinsic sphincter deficiency -- Surgical treatment of anterior vaginal wall prolapse -- Surgical treatment of rectocele and perineal defects -- Surgical treatment of vaginal apex prolapse -- Uterine conservation for the surgical treatment of uterovaginal prolapse -- Obliterative procedures for pelvic organ prolapse -- The use of biologic tissue and synthetic mesh in urogynecology and reconstructive pelvic surgery -- Avoiding and managing lower urinary tract injuries during pelvic surgery -- Managing mesh and other complications after surgeries for urinary incontinence and pelvic organ prolapse -- Fecal incontinence -- Constipation -- Rectovaginal fistula and perineal breakdown -- Rectal prolapse -- Overactive bladder syndrome and nocturia -- Hypersensitivity disorders of the lower urinary tract -- Surgical management of detrusor compliance abnormalities -- Voiding dysfunction and urinary retention -- Lower urinary tract infection -- Urethral diverticula -- Lower urinary tract fistulas -- The effects of gynecologic cancer on lower urinary tract function -- Bladder drainage and urinary protective methods -- Outcomes and quality-of-life measures in pelvic floor research -- The standardization of terminology of lower urinary tract function recommended by the international continence society -- The standardization of terminology of lower urinary tract function: report from the standardization subcommittee of the international continence society -- Standardization reports of the international continence society (ICS) -- Classification system of vaginal prostheses and graft complications recommended by the International Urogynecological Association (IUGA) and International Continence Society (ICS) -- Sample questionnaires for several recommended outcome measures for women with pelvic floor disorders.
- 2007[edited by] Mark D. Walters, Mickey M. Karram.
- 2007 SpringerPatrick J. Culligan and Roger P. Goldberg (eds).
- 2014 SpringerMichael E. Moran.Urolithiasis: A Comprehensive History provides a historical sojourn into the varied manifestations of kidney stone disease. Utilizing historical sources and integrating classic material with new concepts, this new volume provides depth and details on stone disease not found in modern overviews on the topic. This volume serves as a very useful tool for physicians and researchers dealing with kidney stone disease. Written by a renowned expert in the field, Urolithiasis: A Comprehensive History is an in depth resource that heightens our medical understanding of this ancient disease and is of great value to urologists, nephrologists, endocrinologists interested in stone disease.
- 2012 SpringerJamsheer J. Talati, Hans-Goran Tiselius, David M. Albala, Zhangqun Ye, editors.Urolithiasis: Basic Science and Clinical Practice is a comprehensive text that assists urologists in defining the best choice of treatment for each case through a balanced presentation of underlying science, diagnostic methods and practical tips, with additional discussions on educational issues, costs and management of resources. This user-friendly practical resource is replete with full-color illustrations and radiographs, covering all aspects of stone disease, and offering perspectives from Europe, the Americas, China, South Asia, Africa, and Australia. Topics include the biochemical and physiological basis of stone formation, treatment options, complications, assessment of techniques and technologies available, and guidelines on the prevention of stone recurrence. Urolithiasis: Basic Science and Clinical Practice is the definitive text on stone disease and is a must read for young consultants starting a new practice, and urologists in residence and training.
- 2009authors, Robert O. Petersen, Isabell A. Sesterhenn, Charles J. Davis, Jr.Kidney -- Renal pelvis and ureter -- Urinary bladder -- Urethra -- Testis -- Testicular adnexa -- Prostate -- Seminal vesicles -- Penis -- Scrotum.
- 2008 Springeredited by Jeffrey A. Stock, Michael P. Esposito, Vincent J. Lanteri ; foreword by David M. Albala.
- 2008 SpringerProkar Dasgupta, editor ; foreword by James O. Peabody and Mani Menon.
- 2010 ClinicalKey[edited by] John B. Gebhart ; illustrated by Joe Chovan.Anatomy of the female urinary tract / John A. Occhino, Christine A. Heisler, and John B. Gebhart -- Imaging of the female urinary tract / Bohyun Kim, John B. Gebhart, and Akira Kawashima -- Cystourethroscopy for the gynecologist / Gamal M. Ghoniem and John B. Gebhart -- Reconstructive procedures performed on the urethra / John B. Gebhart -- Surgical procedures performed on the urinary bladder / Christopher J. Klingele and John B. Gebhart -- Avoiding and managing ureteral injury during pelvic surgery / Emanuel C. Trabuco and John B. Gebhart.
- 2008[edited by] David G. Bostwick, Liang Cheng.
- 2014 ClinicalKey[edited by] David G. Bostwick, Liang Cheng.Nonneoplastic disease of the kidney / Stephen M. Bonsib -- Neoplasms of the kidney / Gregory T. MacLennan and Liang Cheng -- Renal pelvis and ureter / Stephen M. Bonsib and Liang Cheng -- Fine needle aspiration of the kidney / Andrew A. Renshaw -- Nonneoplastic disorders of the urinary bladder / Robert H. Young -- Neoplasms of the urinary bladder / Liang Cheng, Antonio Lopez-Beltran, Gregory T. MacLennan, Rodolfo Montironi, and David G. Bostwick -- Urine cytology / Deloar Hossain, David Hull, and David G. Bostwick -- Nonneoplastic diseases of the prostate / David G. Bostwick, David Hull, Jun Ma, and Deloar Hossain -- Neoplasms of the prostate / David G. Bostwick, Liang Cheng, and Isabelle Meiers -- Seminal vesicles / David G. Bostwick -- Urethra / Victor E. Reuter -- Nonneoplastic diseases of the testis / Manuel Nistal, Ricardo Paniagua, and Pilar Gonzalez-Peramato -- Neoplasms of the testis / Thomas M. Ulbright and Robert E. Emerson -- Spermatic cord and testicular adnexae / David G. Bostwick -- Penis and scrotum / Jae Y. Ro, Mukul Divatia, Kyu-Rae Kim, Mahul B. Amin, and Alberto G. Ayala -- Adrenal glands / Ernest E. Lack and Edina Paal.
- 2015 SpringerSaid Abdallah Al-Mamari, Salim Said Al-Busaidy, editors.Part 1. Prostate Cancer -- 1. Epidemiology, Etiological factors, Prevention -- 2. PSA Biology and Prostate Cancer Screening -- 3. Symptoms, Signs, Clinical Examination, Primary Diagnostic Methods and Disease Extention Investigations -- 4. Prostate Cancer Treatment.- Part 2. Bladder tumour -- 5. Epidemiology, Pathology, Etiological factors, Prevention, Screening, Symptoms and Signs -- 6. Investigations (Lab and Radiology) -- 7. Bladder Tumour Treatment -- 8. Non-Urothelial Bladder Cancers -- Part 3. Upper Tract Urothelial Carcinomas -- 9. Epidemiology, Risk Factors, Pathology, Tumour Staging -- 10. Diagnosis of UTUC -- 11. Treatment of UTUC, Prognosis and Follow-Up -- Part 4. Renal Cell Carcinomas -- 12. Epidemiology, Etiology -- 13. Pathology, Genetic Profile, Hereditary Syndromes -- 14. Clinical Features -- 15. Physical Examination, Laboratory and Radiological Investigations -- 16. Treatment of Renal Cell Carcinomas.- Part 5. Male Genital Cancer -- 17. Epidemiology and Etiology of Testicular Cancer -- 18. Histological Classification of Testicular Cancer -- 19. Clinical Presentation of Testicular Tumours and Spreading Patterns.- 20. Diagnostic Approaches of Testicular Cancer -- 21. Staging and Risk Categories of Testicular Cancer -- 22. Treatment of Testicular Cancer -- 23. Extra-Gonadal Germ Cell Tumours -- 24. Penile Cancer.- Part 6. Adrenal Gland Cancer -- 25. Epidemiology, Aetiological Factors, Symptoms and Signs of Adrenocortical Carcinomas (ACC) -- 26. Investigations of ACC -- 27. Treatment of Adrenal Gland Cancer -- 28. Malignant Pheochromocytoma -- Part 7. Clinical Scenarios -- 29. Scenarios and Questions -- 30. Proposed Answers.
- 2007 SpringerJonathan Waxman (ed.).
- 2013 SpringerHunter Wessells, editor.Urological Emergencies: A Practical Approach, Second Edition provides a concise, evidence based review of common urgent and emergent urological conditions in children and adults. Descriptions of the appropriate diagnostic and therapeutic considerations on topics of traumatic, infectious, obstructive, hemorrhagic, iatrogenic, vascular and congenital urological emergencies in adults and children are provided. The text is organized by pathophysiology rather than organ system, allowing the reader to develop approaches to the care of patients with acute urological conditions based on mechanism of disease. Relevant pathophysiological background and epidemiology are reviewed, necessary diagnostic testing recommended, and detailed medical, surgical and endourological management approaches have been provided. All chapters incorporate published guidelines and best practice recommendations from appropriate organizations including the American Urological Association, the Centers for Disease Control and Prevention, and various International Consultations on Urological Diseases. New or significantly revised chapters in each of the subsections address innovations in trauma care and prevention, new strategies in management of kidney stones, and special care needs of children with acute urological problems. Urological Emergencies: A Practical Approach, Second Edition is of great value to practicing urologists, urology residents, emergency medicine trainees and practitioners, and primary care providers including MD's, PA's, and NP's without immediate access to urological consultation.
- 2013 SpringerArmenakas, Noel; Cowan, Nigel C.; Hashim, Hashim; Reynard, John; Wood, Dan.Presenting Symptoms of Urological Emergencies / Hashim Hashim -- Lower Urinary Tract Emergencies / John Reynard -- Nontraumatic Renal Emergencies / John Reynard -- Other Infective Urological Emergencies / Hashim Hashim -- Traumatic Urological Emergencies / Noel Armenakas -- Scrotal and Genital Emergencies / John Reynard -- Postoperative Emergencies After Urological Surgery / Hashim Hashim -- Ureteric Colic in Pregnancy / Dan Wood -- Management of Urological Neoplastic Conditions Presenting as Emergencies / Dan Wood -- Pediatric Emergencies / Dan Wood -- Common Emergency Urological Procedures / John Reynard.
- 2012 Springereditor: Daniel A. Shoskes.Evidence-Based and Age-Appropriate Preventive Health Evaluations in Men / Raul J. Seballos -- Clinical Testing of Endothelial Function in Erectile Dysfunction / Titte R. Srinivas and Mark S. Segal -- Controversies and Opportunities for PSA Screening / Benjamin Cohen and Eric A. Klein -- A Phenotypic Approach to the Evaluation and Treatment of Men with Chronic Pelvic Pain Syndrome / Kiranpreet Khurana and Daniel A. Shoskes -- Recurrent Urinary Tract Infections in Men / Stacey C. Carter, Mya E. Levy and Scott I. Zeitlin -- Evaluation and Medical Management of BPH and LUTS in Men / Bilal Chughtai, Richard Lee, Matthew Hall and Alexis E. Te -- The Surgical Treatment of Benign Prostatic Hyperplasia / James C. Ulchaker -- Rational Herbal and Complementary Interventions for Prevention and Treatment of Urological Disorders in Men / Mark A. Moyad -- Androgen Decline in the Aging Male: Making Sense of the "Male Menopause" / Daniel A. Shoskes -- Evaluation and Treatment of Peyronie's Disease / Lawrence S. Hakim -- Primary Care Evaluation and Treatment of Erectile Dysfunction / Martin Miner and Jacob Rajfer -- Surgical Treatment for Erectile Dysfunction / Drogo K. Montague -- Managing Overactive Bladder and Urinary Incontinence in the Male / Humphrey Atiemo and J. Quentin Clemens -- Treatment of Localized Prostate Cancer / Andrew J. Stephenson -- Management of Urethral Strictures in Men / Richard A. Santucci and Mang L. Chen -- Medical and Surgical Interventions in Male Fertility / Kevin Chandler and Edmund Sabanegh Jr. -- Evaluation and Therapy of Chronic Scrotal Content Pain and Epididymitis / Jonas S. Benson and Laurence A. Levine -- Psychosocial Factors in Painful Urogenital Conditions in Men / Dean A. Tripp and Jessica Ginting.
- 2015 SpringerV.H. Nargund, D. Raghavan, H.M. Sandler, editors.With a fully updated look at urological cancers and a comprehensive approach to the basic principles behind chemotherapy, radiotherapy and gene therapy, Urological Oncology, 2nd Edition addresses the advances in MRI, hormone therapy, anesthesia for minimally invasive surgery, drug trials, new therapeutic techniques as well as the new histological types of renal cancer, bringing this second edition fully up-to-date with current practices. Through investigations and multidisciplinary management, Urological Oncology, 2nd Edition reflects the editors? vast experience in treating all urological cancers, and the broad international contributions reflect the urological oncology practice in other developed countries including the United States. Urological Oncology, 2nd Edition will be a valuable tool for residents, specialists, nurse practitioners and other medical personnel in Urology, Radiotherapy, Oncology and Palliative Medicine involved in the treatment of urological cancers.
- 2008 SpringerVinod H. Nargund, Derek Raghavan, and Howard M. Sandler (eds.).
- 2007 SpringerNagaraja P. Rao, Shalom J. Srirangam, and Glenn M. Preminger.
- 2014 SpringerAxel S. Merseburger, Markus A. Kuczyk, Judd W. Moul, editors.Urology at a Glance is a concise, practical guide to diagnostic and therapeutic decision making. The book is divided into two parts. The first focuses on the pathway from symptom to diagnosis and covers the full range of symptoms commonly encountered by the urologist. Any particular symptom can be located within a matter of seconds, and in each case differential diagnosis is explained with the aid of a flow chart. The second part of the book is devoted to the pathway from diagnosis to therapy, with each short chapter devoted to a specific diagnosis. Basic information is provided on the disease in question, along with an outline of state of the art treatment options and possible complications. Again, flow charts are used to help the reader to reach the correct therapeutic decision in different circumstances. Numerous high-definition photographs and illustrations, many of them in color, are also included. The editors and authors are leading urological surgeons and oncologists and internationally recognized authorities in their fields. This book will be a great asset in every urologist?s office and will also prove invaluable for practitioners in related disciplines.
- 2013 OvidMichael T. Macfarlane, M.D., Louisville, Kentucky.The Fifth Edition of Urology in the House Officer Series creates a concise source of clinical information on urology for medical students and residents that can be easily carried for quick reference. Concentrating on the non-surgical aspects of urology, this pocket guide provides the information needed for making a diagnosis and deciding on the proper treatment course. This compact book is separated into two sections, the first, entitled Chief Presentations, covers the most common presenting complaints in the general urology clinic. The second section, entitled, Selected Topics, covers the major areas of urology in greater detail. Covering all diagnostic and treatment approaches for all urologic diseases, this pocket guide is also ideal for family practitioners, physician assistants, nurse practitioners, and emergency room physicians who wish to quickly review a specific urologic presentation.
- 2012 ClinicalKey[edited by] Ming Zhou, George J. Netto, Jonathan I. Epstein.Nonneoplastic disease of the prostate -- Neoplastic disease of the prostate -- Seminal vesicles -- Nonneoplastic disease of the urinary bladder -- Neoplastic disease of the urinary bladder -- Nonneoplastic disease of the kidney -- Neoplastic disease of the kidney -- Renal pelvis and ureter -- Nonneoplastic disease of the testis -- Neoplastic disease of the testis -- Spermatic cord and testicular adnexa -- Disease of the penis, urethra, and scrotum -- Soft tissue tumors and lymphomas.
- 2010 Springer[edited by] Torsten Zuberbier, Clive Grattan, Marcus Maurer.History of Urticaria / M. Greaves -- Aetiopathogenesis of Urticaria / Clive E. H. Grattan -- Classification of Urticaria / Torsten Zuberbier -- Impact of Urticaria: QOL and Performance / Ilaria Baiardini, Fulvio Braido and Giorgio Walter Canonica -- Acute Urticaria / Torsten Zuberbier -- Chronic Urticaria / Marcus Maurer -- Dermographic and Delayed Pressure Urticaria / Frances Lawlor -- Heat and Cold Urticaria / Carsten Bindslev-Jensen -- Solar Urticaria / Tatsuya Horikawa, Atsushi Fukunaga and Chikako Nishigori -- Cholinergic Urticaria and Exercise-Induced Anaphylaxis / Ruth A. Sabroe -- Contact Urticaria / Jürgen Grabbe -- Urticarial Syndromes and Autoinflammation / Kanade Shinkai and Kieron S. Leslie -- Urticaria Vasculitis / Lluís Puig -- Angioedema / Elena Borzova and Clive E. H. Grattan -- Therapy of Urticaria / Bettina Wedi -- Standard Operating Procedures: A Practical Approach / M. Metz and M Magerl.
- 2009 NAPCommittee on the U.S. Commitment to Global Health, Board on Global Health, Institute of Medicine of the National Academies.Summary -- Charge to the committee -- a prominent role for health in U.S. foreign policy -- Progress in global health can be achieved now -- Urgent opportunity for action -- Restructure the U.S. global health enterprise -- Mobilize financial resources for health -- Focus U.S. government efforts on health outcomes -- Advance U.S. strengths in global health knowledge -- Support and collaborate with the WHO -- Call to action.
- 2009 NAPCommittee on the U.S. Commitment to Global Health, Board on Global Health, Institute of Medicine of the National Academies.The U.S. Commitment to Global Health examines ways in which the United States could contribute to advances in global health, including the following four areas of action: Generate and share knowledge to address problems endemic to poor countries, Invest in people, institutions, and capacity building in resource-poor settings, Increase both quantity and quality of U.S. financial commitments to global health, Be a respectful partner and leader.
- 1989- CDC, Scroll down to U.S. Decennial Life Tables for 1989 to 1991.no. 1. Alabama -- no. 2. Alaska -- no. 3. Arizona -- no. 4. Arkansas -- no. 5. California -- no. 6. Colorado -- no. 7. Connecticut -- no. 8. Delaware -- no. 9. District of Columbia -- no. 10. Florida -- no. 11. Georgia -- no. 12. Hawaii -- no. 13. Idaho -- no. 14. Illinois -- no. 15. Indiana -- no. 16. Iowa -- no. 17. Kansas -- no. 18. Kentucky -- no. 19. Louisiana -- no. 20. Maine -- no. 21. Maryland -- no. 22. Massachusetts -- no. 23. Michigan -- no. 24. Minnesota -- no. 25. Mississippi -- no. 26. Missouri -- no. 27. Montana -- no. 28. Nebraska -- no. 29. Nevada -- no. 30. New Hampshire -- no. 31. New Jersey -- no. 32. New Mexico -- no. 33. New York -- no. 34. North Carolina -- no. 35. North Dakota -- no. 36. Ohio -- no. 37. Oklahoma -- no. 38. Oregon -- no. 39. Pennsylvania -- no. 40. Rhode Island -- no. 41. South Carolina -- no. 42. South Dakota -- no. 43. Tennessee -- no. 44. Texas -- no. 46. Vermont -- no. 47. Virginia -- no. 48. Washington -- no. 49. West Virginia -- no. 50. Wisconsin-- no. 51. Wyoming.Also available: Print – v. 1-51, 1998.
- 2013 NAPPanel on Understanding Cross-National Health Differences Among High-Income Countries ; Steven H. Woolf and Laudan Aron, editors ; Committee on Population, Division of Behavioral and Social Sciences and Education ; Board on Population Health and Public Health Practice, Institute of Medicine ; National Research Council and Institute of Medicine of the National Academies."The United States is among the wealthiest nations in the world, but it is far from the healthiest. Although life expectancy and survival rates in the United States have improved dramatically over the past century, Americans live shorter lives and experience more injuries and illnesses than people in other high-income countries. The U.S. health disadvantage cannot be attributed solely to the adverse health status of racial or ethnic minorities or poor people: even highly advantaged Americans are in worse health than their counterparts in other, "peer" countries. In light of the new and growing evidence about the U.S. health disadvantage, the National Institutes of Health asked the National Research Council (NRC) and the Institute of Medicine (IOM) to convene a panel of experts to study the issue. The Panel on Understanding Cross-National Health Differences Among High-Income Countries examined whether the U.S. health disadvantage exists across the life span, considered potential explanations, and assessed the larger implications of the findings. U.S. Health in International Perspective presents detailed evidence on the issue, explores the possible explanations for the shorter and less healthy lives of Americans than those of people in comparable countries, and recommends actions by both government and nongovernment agencies and organizations to address the U.S. health disadvantage"--Publisher's description.
- 2011 CRCnetBASEMichael E. Wiklund, Jonathan Kendler, Allison Y. Strochlic."Informative, practical, and engaging, this handbook covers how to conduct usability tests of medical devices. Recognizing that the intended readers, including marketers, engineers, and regulatory affairs specialists, are busy and disinclined to read lengthy textbooks, this book has been carefully designed to be concise and visual, allowing readers to read it all in one sitting or jump from one section to another as needed. The book provides a general understanding of usability testing and reviews key concepts. It highlights the challenges of validating that protects against dangerous errors that could lead to patient injury and death"--Provided by publisher.
- 2016 SpringerBirgit Völlm, Norbert Nedopil, editors.
- 2014 ScienceDirectedited by Jennifer A Doudna and Erik J Sontheimer.This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers recent research and methods development for changing the DNA sequence within the genomes of cells and organisms. Focusing on enzymes that generate double-strand breaks in DNA, the chapters describe use of molecular tools to introduce or delete genetic information at specific sites in the genomes of animal, plant and bacterial cells.
- [By R. Bethene Ervin, Jacqueline D. Wright, and Jocelyn Kennedy-Stephenson].
- 2007The Sexually Transmitted Diseases Diagnostics Initiatve.
- Sandra R. Wilson, Norma Starr-Schneidkraut, Michael D. Cooper ; submitted to Elliot R. Siegel.
- 2008The Evidence-Based Medicine Working Group ; [edited by] Drummond Rennie ... [et al.].How to use the medical literature and this book to improve your patient care -- The philosophy of evidence-based medicine -- What is the question? -- Finding the evidence -- Why study results mislead: bias and random error -- Therapy -- Does treatment lower risk? Understanding the results -- Confidence intervals -- Advanced topics in the validity of therapy trials -- Hypothesis testing -- Advanced topics in applying the results of therapy trials -- Harm -- Advanced topics in harm -- The process of diagnosis -- Differential diagnosis -- Diagnostic tests -- Advanced topics in diagnosis -- How to critically appraise an article about prognosis -- Summarizing the evidence -- Advanced topics in systematic reviews -- How to use a patient management recommendation -- Advanced topics in moving from evidence to action.
- 2016edited by Erika Dyck, Larry Stewart.The hermaphrodite of Charing Cross / Anita Guerrini -- Galvanic humans / Rob Iliffe -- The subject as instrument : galvanic experiments, organic apparatus and problems of calibration / Joan Steigerwald -- Shocking subjects : human experiments and the material culture of medical electricity in eighteenth-century England / Paola Bertucci -- Pneumatic chemistry, self-experimentation and the burden of revolution, 1780-1805 / Larry Stewart -- Food fights : human experiments in late nineteenth-century nutrition physiology / Elizabeth Neswald -- Experimenting with radium therapy : in the laboratory & the clinic / Katherine Zwicker -- Anthropometry, race, and eugenic research : "Measurements of growing Negro children" at the Tuskegee Institute, 1932-1944 / Paul A. Lombardo -- Nazi human experiments : the victims' perspective and the post-Second World War discourse / Paul Weindling -- A eugenics experiment : sterilization, hyperactivity and degeneration / Erica Dyck.Also available: Print – 2016
- 2008 CRCnetBASEHugh Cartwright ; chapter 10, Evolvable developmental systems, contributed by Nawwaf Kharma.
- 2008 Springeredited by Mandy Ryan, Karen Gerard, Mabel Amaya-AmayaDces: what are they and their application in health a user's guide -- Discrete choice experiments in a nutshell -- Designing discrete choice experiments for health care -- Practical issues in conducting a discrete choice experiment -- Comments on the design of the choice experiment -- Case studies in valuing health and health care -- Using discrete choice experiments to go beyond clinical outcomes when evaluating clinical practice -- Using discrete choice modeling to investigate breast screening participation -- Preferences for health care programmes: results from a general population discrete choice survey -- Examining the preferences of health care providers: an application to hospital consultants -- Methodological issues -- The price proxy in discrete choice experiments: issues of relevance for future research -- "Irrational" stated preferences: a quantitative and qualitative investigation -- Using stated preference and revealed preference data fusion modelling in health care -- Conclusions -- Concluding thoughts.
- Using eye movements as an experimental probe of brain function : a symposium in honor of Jean Buttner-Ennever2008 ScienceDirectedited by Christopher Kennard, R. John Leigh.Mapping the oculomotor system -- Neuronal signalling expression profiles of motoneurons supplying multiply or singly innervated extraocular muscle fibres in monkey -- Histochemical characterisation of trigeminal neurons that innervate monkey extraocular muscles -- Functional anatomy of the extraocular muscles during vergence -- Induced extraocular muscle afferent signals: from pigeons to people -- Monkey primary somatosensory cortex has a proprioceptive representation of eye position -- Acute superior oblique palsy in the monkey: effects of viewing conditions on ocular alignment and modelling of the ocular motor plant -- Dynamic aspects of trochlear nerve palsy -- Ocular motor nerve palsies: implications for diagnosis and mechanisms of repair -- Extraocular proprioception and new treatments for infantile nystagmus syndrome. Neural circuits for triggering saccades in the brainstem -- Brainstem circuits controlling lid-eye coordination in monkey -- Defining the pupillary component of the periocular preganglionic population with in a unitary Edinger-Westphal nucleus -- Frontal eye field signals that may trigger the brainstem saccade generator -- The role of omnipause neurons: why glycine? -- Applying saccade models to account for oscillations -- Dynamics of saccadic oscillations -- Effects of failure of development of crossing brainstem pathways on ocular motor control -- Neuronal evidence for individual eye control in the primate cMRF. Complex spike activity signals the direction and size of dysmetric saccade errors -- Role of the MST-DLPN pathway in smooth pursuit adaptation -- Lesions of the cerebellar nodulus and uvula in monkeys: effect on otolith-ocular reflexes -- Vergence eye movement signals in the cerebellar dorsal vermis -- Oculomotor anatomy and the motor-error problem: the role of the paramedian tract nuclei -- Impulsive testing of semicircular canal function -- Inter-ocular differences of the horizontal vestibulo-ocular reflex during impulsive testing -- Control of ocular torsion in the rotational vestibulo-ocular reflexes -- Do humans how velocity-storage in the vertical rVOR? -- Preserved otolith function in patients with cerebellar atrophy and bilateral vestibulopathy -- Three-dimensional kinematics of saccadic eye movements in humans with cerebellar degeneration -- Inferior olive hypertrophy and cerebellar learning are both needed to explain ocular oscillations in oculopalatal tremor -- Impulsive head rotation resets oculopalatal tremor. Human ocular following: evidence that responses to large-field stimuli are limited by local and global inhibitory influences -- Short-latency disparity vergence eye movements -- MSTd neurons during ocular following and smooth pursuit perturbation -- Neural activity in cortical areas MST and FEF in relation to smooth pursuit gain control -- Eye position and cross-sensory learning both contribute to prism adaptation of auditory space -- Hysteresis effects of the subjective visual vertical during continuous quasi-static whole-body roll rotation -- Perception of self motion during and after passive rotation of the body around an earth-vertical axis -- The freezing rotation illusion -- Geometrical considerations on canal-otolith interactions during OVAR and Bayesian modelling -- Listing's plane and the otolith-mediated gravity vector -- A reinterpretation of the purpose of the translational vestibulo-ocular reflex in human subjects -- Dynamics of binocular fixation of targets during fore-aft motion -- Differential coding of head rotation by lateral-vertical canal convergent central vestibular neurons -- Cyclovergence evoked by up-down acceleration along longitudinal axis in humans -- Oblique gaze shifts: head movements reveal new aspects of component coupling -- Head movement control during head-free gaze shifts -- Postural changes during eye-head movements -- Cortical processing in vestibular navigation -- Foot rotation contribution to trunk and gaze stability during whole-body mediated gaze shifts -- Supraspinal locomotor control in quadrupeds and humans -- Private lines of cortical visual information to the nucleus of the optic tract and dorsolateral pontine nucleus -- Gravity perception in cerebellar patients. Brain mechanisms for switching from automatic to controlled eye movements -- The frontal eye field as a prediction map -- Volition and eye movements -- Negative motivational control of saccadic eye movement by the lateral habenula -- Eye movements as a probe of attention -- Using transcranial magnetic stimulation to probe decision-making and memory -- Supplementary eye field contributions to the execution of saccades to remembered target locations -- Multiple memory-guided saccades: movement memory improves the accuracy of memory-guided saccades -- Visual vector inversion during memory antisaccades -- Predictive signals in the pursuit area of the monkey frontal eye fields -- Internally generated smooth eye movement: its dynamic characteristics and role in randomized and predictable pursuit -- Predictive disjunctive pursuit of virtual images perceived to move in depth -- Tracking in 3-D space under natural viewing condition -- Exploring the pulvinar path to visual cortex -- The role of the human pulvinar in visual attention and action. How disturbed visual processing early in live leads to disorders of gaze-holding and smooth pursuit -- Manifest latent nystagmus: a case of sensori-motor switching -- Eye hyperdeviation in mouse cerebellar mutants is comparable to the gravity-dependent component of human downbeat nystagmus -- New insights into the upward vestibulo-oculomotor pathways in the human brainstem -- Mechanisms of vestibulo-ocular reflex (VOR) cancellation in spinocerebellar ataxia type 3 (SCA-3) and episodic ataxia type 2 (EA-2) -- Modelling drug modulation of nystagmus -- Aminopyridines for the treatment of cerebellar and ocular motor disorders -- Baclofen, motion sickness susceptibility and the neural basis for velocity storage -- Oculomotor deficits indicate the progression of Huntington's Disease -- Eye movements in visual search indicate impaired saliency processing in Parkinson's disease -- Ocular motor anatomy in a case of interrupted saccades -- Mechanism of interrupted saccades in patients with late-onset Tay-Sachs disease -- Conjugacy of horizontal saccades -- The neuroanatomical basis of slow saccades in spinocerebellar ataxia type 2 (Wadia-subtype) -- Selective, circuit-wide sparring of floccular connections in hereditary olivopontine cerebellar atrophy with slow saccades -- A quick look at slow saccades after cardiac surgery -- Eye and head torsion is affected in patients with midbrain lesions -- Horizontal saccadic palsy associated with gliosis of the brainstem midline.
- Using heterogeneous sources of biological knowledge to improve the identification of differentially expressed genes2009/2010Bernie Joseph Daigle, Jr.
- Using high throughput yeast strain construction and precision analysis tools to explore evolutionary processes2007/2008Erik Jedediah Dean.
- 2012Alan Hunter Shain.Pancreatic ductal adenocarcinoma, subsequently referred to as pancreatic cancer, is one of the most deadly cancers with a five-year survival of only 5%. Typical treatment regimens include surgery and chemotherapy while targeted therapies are lacking. A better understanding of the underlying cancer biology may yield novel therapeutic targets. The field of genomics has transformed our ability to study cancer. Over the past two decades, microarray and sequencing based innovations have enabled biology to be carried out at the --omic scale (discussed further in Chapter 1). This dissertation employs --omic level analysis to query the differences between the pancreatic cancer genome and the normal human genome. First, high throughput structural characterizations were performed in order to annotate the mutated, rearranged, deleted, and amplified genes across seventy pancreatic cancers. These assays identified hundreds of candidate cancer genes. Among these candidates, SMURF1 was validated to be an oncogene (Chapter 2). Furthermore, various subunits of the SWI/SNF chromatin remodeling complex were validated to be tumor suppressor genes (Chapter 3). While SMURF1 and SWI/SNF were validated individually, the other candidates from structural studies were evaluated in parallel shRNA competive growth screen. From this, we characterize nine genes further -- some previously known to play a role in cancer and some novel (Chapter 4). The sum total of all of this work is a much deeper understanding of the biology of pancreatic cancer, yielding many novel therapeutic targets and hopefully allowing scientists to gain a foothold in the fight against this disease.
- 2010 CRCnetBASEedited by Walter A. Korfmacher.Strategies and techniques for bioanalytical assays as part of new drug discovery / Walter A. Korfmacher -- The drug discovery process: from molecules to drugs / Mike S. Lee, Steven E. Klohr -- PK principles and PK/PD applications / Hong Mei, Richard A. Morrison -- Mass spectrometry for in vitro ADME screening / Inhou Chu -- Metabolite identification strategies and procedures / Ragu Ramanathan, S. Nilgün Çömezoǧlu, W. Griffith Humphreys -- Reactive metabolite screening and covalent-binding assays / Gérard Hopfgartner -- Fast metabolite screening in a discovery setting / Xiaoying Xu -- Fast chromatography with UPLC and other techniques / Sam Wainhaus -- Supercritical fluid chromatography-mass spectrometry / Yunsheng Hsieh -- Biomarkers of efficacy and toxicity: discovery and assay / Joanna R. Pols -- Imaging mass spectrometry for small molecules / Fangbiao Li -- MALDI IMS for proteins and biomarkers / Michelle L. Reyzer, Richard M. Caprioli -- Ambient ionization methods and their early applications in ADME studies / Jing-Tao Wu -- Pharmaceutical applications of accelerator mass spectrometry / Lan Gao, Swapan Chowdhury.
- 2016 SpringerH.G. Stratmann.
- 2011 CRCnetBASENicholas J. Horton, Ken Kleinman."R is a general purpose statistical software package used in many fields of research. It is licensed for free, as open-source software. The system has been developed by a large group of people, almost all volunteers"--Preface.
- Ubiquitin and protein degradation. Part A-B — Understanding the interaction between graft placement, gait mechanics, and cartilage morphology as a pathway to osteoarthritis in the ACL reconstructed knee (100)
- Understanding the mechanis of mammalian damage tolerance proteins in suppressing damage-specific mutagenesis — Using R for data management, statistical analysis, and graphics (100)
- Using R for numerical analysis in science and engineering — Uveitis-- fundamentals and clinical practice. 4th ed. (30)
- Harrison's Principles of Internal Medicine
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- Robbins & Cotran Pathologic Basis of Disease
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- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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