- Ubiquitin and protein degradation. Part A-B — Understanding the molecular mechanisms of cardiomyopathy-causing mutations in sarcomeric proteins (100)
- Understanding the role of lipids in tear-film stability — Using integrative genomic approaches to understand the biology of pancreatic cancer (100)
- Using mass spectrometry for drug metabolism studies. 2nd ed. — Uveitis-- fundamentals and clinical practice. 4th ed. (31)
- pt. A-B, 2005. ScienceDirectpt. B ScienceDirectDeshaies, Raymond Joseph.Also available: Print – pt. A-B, 2005.
- 2012 Springer ProtocolsDohmen, R. Jürgen; Scheffner, Martin.
- 2009/2010Estay, Ivette Shiba.
- 2009 SpringerHaendler, B.; Jentsch, Stefan.
- 2005 Springer ProtocolsCyr, Douglas M.; Patterson, Cam.Assays of proteasome-dependent cleavage products / Stefan Tenzer and Hansjörg Schild -- Identification of components of protein complexes / Carol E. Parker ... [et al.] -- Mass spectroscometric determination of protein ubiqitination / Carol E. Parker ... [et al.] -- Reconstitution of endoplasmic reticulum-associated degradation using yeast membranes and cytosol / Robert J. Lee, Ardythe A. McCracken, and Jeffrey L. Brodsky -- Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation / Eric Carlson ... [et al.] -- Deubiquitinating enzyme purifucation, assay inhibitors and characterization / Nathaniel S. Russell and Keith D. Wilkinson -- Measuring ubiquitin conjugation in cells / Edward G. Mimnaugh and Leonard M. Neckers -- Assays for proteasome assembly and maturation / R. Jürgen Dohmen ... [et al.] -- N-terminal ubiquitination / Aaron Ciechanover -- Quantitating defective ribosome products / Shu-Bing Qian, Jack R. Bennink, and Jonathan W. Yewdell -- Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis / Antje Schäfer and Dieter H. Wolf -- Endoplasmic reticulum-associated protein quality control and degradation: genome wide screen for ERAD components / Antje Schäfer and Dieter H. Wolf -- Cystic fibrosis transmembrane conducatance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells / J. Michael Younger ... [et al.] -- Aggresome formation / Michael J. Corboy, Philip J. Thomas, and W. Christian Wigley -- Detection of sumoylated proteins / Roland S. Hilgarth and Kevin D. Sarge -- Proteasome inhibitors in cancer therapy / Robert Z. Orlowski -- Parkinson disease: assays for the ubiquitin ligase activity of neural parkin / Michael G. Schlossmacher and Hideki Shimura. Small-molecule inhibitors of proteasome activity / Maria Gaczynska and Pawel A. Osmulski -- Purification of E1 and E1-like enzymes / Arthur L. Haas -- Assays for RING family ubiquitin ligases / Manabu Furukawa, Paul S. Andrews, and Yue Xiong -- Ubiquitin chain synthesis / Shahri Raasi and Cecile M. Pickart -- Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast / David S. Leggett, Michael H. Glickman, and Daniel Finley -- Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome / Chang-Wei Liu ... [et al.] -- Cell-free assay for ubiquitin-independent proteasomal protein degradation / Chaim Kahana and Yuval Reiss --
- Hasman, Arie.
- UHMWPE biomaterials handbook : ultra high molecular weight polyethylene in total joint replacement and medical devices. 2nd ed.2009 ScienceDirect2009 KnovelKurtz, Steven M.A primer on UHMWPE / Steven M. Kurtz -- From ethylene gas to UHMWPE component : the process of producing orthopedic implants / Steven M. Kurtz -- Packaging and sterilization of UHMWPE / Steven M. Kurtz -- The origins of UHMWPE in total hip arthroplasty / Steven M. Kurtz -- The clinical performance of UHMWPE hip replacements / Steven M. Kurtz -- Contemporary total hip arthoplasty : hard-on-hard bearings and highly crosslinked UHMWPE / Steven M. Kurtz, Kevin Ong -- The origins and adaptations of UHMWPE for knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in shoulder replacements / Stefan M. Gabriel -- The clinical performance of UHMWPE in elbow replacements / Judd S. Day -- Applications of UHMWPE in total ankle replacements / Allyson Ianuzzi, Chimba Mkandawire -- The clinical performance of UHMWPE in the spine / Steven M. Kurtz, Marta L. Villarraga, Allyson Ianuzzi -- Highly crosslinked and melted UHMWPE / Orhun K. Muratoglu -- Highly crosslinked and annealed UHMWPE / John H. Dumbleton, Aiguo Wang, Kate Sutton ...[et al.] -- Highly crosslinked UHMWPE doped with vitamin E / Ebru Oral, Orhun K. Muratoglu -- Vitamin-E-blended UHMWPE biomaterials / Steven M. Kurtz, Pierangiola Bracco, Luigi Costa -- Composite UHMWPE biomaterials and fibers / Steven M. Kurtz -- UHMWPE / hyluronan microcomposite biomaterials / Susan P. James, Rachel (Kurkowski) Oldinski, Min Zhang ...[et al.] -- High pressure crystallized UHMWPEs / Anuj Bellare, Steven M. Kurtz -- Compendium of highly crosslinked UHMWPEs / Steven M. Kurtz -- Mechanisms of crosslinking, oxidative degradation and stabilization of UHMWPE / Luigi Costa, Pierangiola Bracco -- In vivo of UHMWPE / Steven M. Kurtz -- Pathophysiologic reactions to UHMWPE wear particles / Marla J. Steinbeck, Ryan M. Baxter, Theresa A. Freeman -- Characterization of physical, chemical, and mechanical properties of UHMWPE / Stephen Spielgelberg -- Tribological assessment of UHMWPE in the hip / Aaron Essner MS, Aiguo Wang -- Tribological assessment of UHMWPE in the knee / Hani Haider -- Characterization of UHMWPE wear particles / Tipper JL., Richards L., Ingham E. ...[et al.] -- Clinical surveillance of UHMWPE using radiographic methods / Charles R. Bragdon -- ESR insights into macroradicals in UHMWPE / M. Shah Jahan -- Fatigue and fracture of UHMWPE / Francisco J. Medel, Jevan Furmanski -- Development and application of the notched tensile test to UHMWPE / Michael C. Sobieraj, Clare M. Rimnac -- Development and application of the small punch test to UHMWPE / Avram A. Edidin -- Nano- and microindentation testing of UHMWPE / Jeremy L. Gilbert, James D. Wernle -- MicroCT analysis of wear and damage in UHMWPE / Daniel MacDonald, Anton Bowden, Steven M. Kurtz -- Computer modeling and simulation of UHMWPE / Anton E. Bowden, Erin Oneida, Jorgen Bergström.
- 2005- WileyUllmann, Fritz.Covers science and technology in all areas of industrial chemistry, containing nearly 1000 major articles with more than 16 million words, nearly 10,000 tables, 30,000 figures, and literature sources and cross-references. It also includes full text index, author index, CAS registry number index, and keyword index.
- 2007Freeman, Brian S.
- 2013 AccessMedicineFreeman, Brian S.Online 3rd edition inlcudes only selected chapters as of 1/10/2014.
- Koushik Shaw.
- 2006 SpringerBerliner, Lawrence J.; Robitaille, Pierre-Marie.
- Ultra-high molar mass linear polyacrylamide (LPA) networks for microchannel electrophoresis : tuning LPA matrix dynamics and rheological responses to optimally impact DNA migration mechanism2012Niedringhaus, Thomas Patrick; Barron, Annelise E.; Fuller, Gerald G.; Shaqfeh, Eric S. G.Since the 2003 completion of the human genome by means of the Sanger-based DNA sequencing strategy and capillary array electrophoresis, the scientific and medical community has worked to make personalized medicine a reality. Next-generation DNA sequencing technologies with astoundingly high throughput are now in use and have provided exciting new capabilities. However, next-generation instruments are currently incapable of providing highly accurate, long sequencing read lengths, have difficulty sequencing through repetitive sequences, and have yet to "scale down" well for point-of-care diagnostics. The 600 to 700 base read lengths at 98% accuracy that are provided by capillary electrophoresis and the Sanger method are still the gold standard for medical sequencing. In recent years, there has been a natural progression from CAE to microchip electrophoresis. Microchip electrophoresis provides highly accurate sequencing at a small compromise to read length (~ 500 to 600 bases) while offering the potential for a significant increase in throughput due to the reduced separation times and the possibility to create a lab-on-a-chip (LOC) device that integrates upstream sample preparation steps. These advantages render CAE and microchip electrophoresis platforms desirable for clinical diagnostic tests since they offer highly accurate sequencing needed to analyze medically relevant genes and precisely genotype forensic samples. Therefore, this work focuses on understanding variables that influence the migration mechanism of single-stranded DNA (ssDNA) through physically- entangled polymer matrices used in CAE and microchip electrophoresis in an effort to increase throughput and bridge the gap for clinical adoption. First, I discuss the application of the biased reptation model (BRM) to CAE sequencing separations. In this study, I report the synthesis and characterization of an ultra-high molar mass linear polyacrylamide (LPA) to be used as a replaceable, physically-entangled polymer matrix and the migration mechanisms of ssDNA through the LPA matrices are evaluated using reptation plots. Properties of the LPA matrices (i.e. average pore size and viscosity) is tuned by the overall polymer concentration as well as mixing ultra-high and low molar mass LPA. In the end, a blended LPA solution generates a dynamically responsive polymer matrix that increases sequencing read lengths by delaying the onset of oriented biased reptation. The near-optimal blended LPA matrix which extends average read lengths to 830 bases in ~1 hour on a high-throughput CAE instrument. This represents a performance that is substantially better than the best commercial instrument/matrix CAE system available, which takes 2 hours to produce 830 bases. This was achieved by matrix optimization only. Second, I discuss transient effects on the DNA sequencing read length caused by shear-induced LPA stretching during the pressure-induced capillary loading of the polymer matrix which results in entanglement inhomogeneity. The network inhomogeneity, in turn, increases peak widths due to mobility variation among ssDNA fragments in the radial direction of the microchannel. The contributions of the matrix rheological properties, microchannel dimensions, and loading pressure to the shear forces placed on the matrix during loading are thoroughly examined. Finally, tests were carried out on microfluidic chips to reduced polymer network disruption. In the end, the loading conditions were optimized to enable loading and unloading of a sequencing matrix in less than 1 minute that also provides sequencing read lengths on the order of 550 to 600 bases in ~ 8 minutes. These results provide universal parameters for high-throughput loading of polymer matrices into capillaries and microchips used in electrophoretic genotyping assays and newly invented LOC platforms, such that the performance of the matrix will be optimal.
- 2008Marticke, Simone Sigrid.
- 2008 SpringerBraun, Markus; Gilch, Peter; Zinth, Wolfgang.Ultrahigh-resolution optical coherence tomography using femtosecond lasers / J. G. Fujimoto ... [et al.] -- Two-photon laser scanning microscopy / A. Nimmerjahn, P. Theer, F. Helmchen -- Femtosecond lasers in ophthalmology: surgery and imaging / J. F. Bille -- Ultrafast peptide and protein dynamics by vibrational spectroscopy / P. Hamm -- Photosynthetic light-harvesting / T. Pullerits, T. Polivka, V. Sundström -- Primary photosynthetic energy conversion in bacterial reaction centers / W. Zinth, J. Wachtveitl -- Ultrafast primary reactions in the photosystems of oxygen-evolving organisms / A. R. Holzwarth -- Primary photochemistry in the photoactive yellow protein: the prototype xanthopsin / D. S. Larsen, R. van Grondelle, K. J. Hellingwerf -- Structure based kinetics by time-resolved X-ray crystallography / M. Schmidt -- Primary reactions in retinal proteins / R. Diller -- Ultrashort laser pulses in single molecule spectroscopy / E. Houstein, P. Schwille.
- 2008 ClinicalKeyCallen, Peter W.Also available: Print – 2008
- 2015 SpringerFerrada, Paula.I. Basics of Ultrasound -- 1. The Machine -- 2. Frequency and probes -- 3. Common Artifacts -- 4. The Doppler Effect -- II. Thoracic Ultrasound -- 5. The Pleura -- 6. The Lung -- 7. Procedures -- 8. Cases -- III. Echocardiogram for the Intensivist -- 9. Rationale -- 10. Limited echocardiogram vs. full service echo -- 11. The Windows -- 12. The Measurements -- 13. The interpretation -- 14. Cases -- IV. Vascular Ultrasound in the Critically Ill -- 15. Deep Venous Thrombosis -- 16. Line Placement -- 17. Cases -- V. Basic Abdominal Ultrasound in the ICU -- 18. Evaluation for free fluid -- 19. Basic Renal ultrasound -- 20. Evaluation of the Gallbladder -- 21. Procedures -- 22. Cases -- VI. Soft Tissue -- 23. Facial Dehiscence -- 24. Soft tissue masses and collections -- VII. Other Issues -- 25. Training Challenges -- 26. Credentialing Process -- 27. Billing and Coding.
- 2011 SpringerSchäberle, Wilhelm.Fundamental principles -- Peripheral arteries -- Peripheral veins -- Shunts -- Extracranial cerebral arteries -- Visceral and retroperitoneal vessels -- Penile and scrotal vessels.
- 2012 SpringerD'Onofrio, Mirko.Ultrasound Imaging / Anna Gallotti and Fabrizio Calliada -- Transabdominal Ultrasonography of the Pancreas / Elisabetta Buscarini and Salvatore Greco -- Endoscopic Ultrasonography of the Pancreas / Elisabetta Buscarini and Stefania De Lisi -- Percutaneous Ultrasound Guided Interventional Procedures in Pancreatic Diseases / Elisabetta Buscarini and Guido Manfredi -- Intraoperative Ultrasonography of the Pancreas / Mirko D'Onofrio, Emilio Barbi, Riccardo De Robertis, Francesco Principe and Anna Gallotti, et al. -- Pancreatic Anatomy, Variants and Pseudolesions of the Pancreas / Emilio Barbi, Salvatore Sgroi, Paolo Tinazzi, Stefano Canestrini and Anna Gallotti, et al. -- Pancreatitis and Pseudocysts / Steffen Rickes and Holger Neye -- Solid Pancreatic Tumors / Christoph F. Dietrich, Michael Hocke, Anna Gallotti and Mirko D'Onofrio -- Cystic Pancreatic Tumors / Mirko D'Onofrio, Paolo Giorgio Arcidiacono and Massimo Falconi -- Rare Pancreatic Tumors / Roberto Malagò, Ugolino Alfonsi, Camilla Barbiani, Andrea Pezzato and Roberto Pozzi Mucelli -- Imaging Correlation / Marie-Pierre Vullierme and Enrico Martone -- Pancreatic Lesions: Pathologic Correlations / Paola Capelli and Alice Parisi -- Clinical and Imaging Scenarios / Anna Gallotti and Riccardo Manfredi -- Flowcharts in Pancreatic Diseases / Elisabetta Buscarini.
- 2014 SpringerDraghi, Ferdinando.This practice-oriented book, containing a wealth of high-quality ultrasound images, provides clear, concise, and complete coverage of the normal anatomy of the hand and wrist - tendons, nerves, and vascular structures - as well as the main pathologic conditions encountered in this area. The ultrasound images have been acquired with state of the art scanners and carefully labeled to facilitate recognition of each and every anatomic structure. Helpful comparison is also made with images and findings obtained using other diagnostic techniques, including in particular magnetic resonance imaging. The lucid text is complemented by practical tables summarizing key points for ease of reference. Readers will find Ultrasonography of the Upper Extremity to be a rich source of information on anatomy, examination techniques, and ultrasound appearances of one of the anatomic regions to have benefited the most from the technological revolution that has taken place in the field of ultrasonography during recent years. The book will appeal to both novice and experienced practitioners, including above all radiologists and ultrasound technicians but also rheumatologists and orthopedic surgeons.
- 2015 SpringerSilvestri, Enzo; Muda, Alessandro; Orlandi, Davide.The book provides a comprehensive description of the basic ultrasound principles, normal anatomy of the lower limb muscles and classification of muscle strain injures. Ultrasound images are coupled with anatomical schemes explaining probe positioning and scanning technique for the various muscles of the thigh and leg. For each muscle, a brief explanation of normal anatomy is also provided, together with a list of tricks and tips and advice on how to perform the ultrasound scan in clinical practice. This book is an excellent practical teaching guide for beginners and a useful reference for more experienced sonographers.
- 2012 SpringerNicolaides, Andrew N.
- 2010 SpringerKharchenko, V. P.As the basis for this book, the authors have analyzed more than 100,000 ultrasound examinations performed between 1995 and 2008 in patients with thyroid and parathyroid disease, as well as many thousands of diagnostic and therapeutic ultrasound-guided minimally invasive procedures. The opening chapters include discussion of current ultrasound techniques, pitfalls, and ultrasound examination of the thyroid in children. Detailed attention is then devoted to findings in the normal thyroid and in the presence of diffuse and focal changes.
- 2012 SpringerLaine, Andrew; Sanches, João Miguel; Suri, Jasjit S.Ultrasound Imaging: Advances and Applications presents some of the recent advances in Ultrasound imaging technology covering several organs and techniques in a Biomedical Engineering (BME) perspective. The focus of the book is in the algorithms, methodologies and systems developed by multidisciplinary research teams of engineers and physicians for Computer-Aided Diagnosis (CAD) purposes. Cardiovascular and Cancer, the most common life-threatening diseases in western countries, are two of the most important topics focused in the book. However, other advanced issues are also presented such as Intravascular Ultrasound, 3D US and Ultrasound in Computer-Aided Surgery (CAS). Some chapters are direct contributions from medical research groups where Ultrasound has also received great attention in the last decade. By this, new techniques based on Ultrasound were introduced in the clinical practice for diagnosis and therapeutics, mainly in hospital facilities.
- 2014 SpringerStadtmauer, Laurel A.; Tur-Kaspa, Ilan.Part I: Ultrasound Technique -- Ultrasound in Reproductive Medicine: Is It Safe?- Principles of 3D Ultrasound -- Two Dimensional and Three Dimensional Doppler in Reproductive Medicine -- Legal Aspects of Ultrasound Imaging in Reproductive Medicine -- Part II: Ultrasound in Infertility Workup -- The Normal Ovary -- Ovarian Reserve and Ovarian Cysts -- Ultrasound and PCOS -- The Normal Uterus -- Congenital Uterine Anomalies -- Uterine Fibroids -- Endometrial Polyps -- Intrauterine Adhesions -- Sonohysterography (SHG) in Reproductive Medicine -- Evaluation of Tubal Patency (HyCoSy, Doppler) -- Hydrosalpinx -- Virtual Hysterosalpingography: A New Diagnostic Technique for the Study of the Female Reproductive Tract -- Ultrasound in Male Infertility -- Part III: Ultrasound in Infertility Treatment -- Ultrasound in Follicle Monitoring for Ovulation Induction/IUI -- 2D Ultrasound in Follicle Monitoring for ART -- 3D Ultrasound in Follicle Monitoring for ART -- Ultrasound Guided Surgical Procedures -- Ultrasound Role in Embryo Transfers -- Ultrasound and Ovarian Hyperstimulation Syndrome -- Pregnancy of Unknown Viability -- Ultrasound Evaluation of Ectopic Pregnancy -- Focused Ultrasound for Treatment of Fibroids.
- 2007Timor-Tritsch, Ilan E.; Goldstein, Steven R.Ultrasound in gynecology: development and continuing evolution -- Applied physics: selecting and adjusting the equipment -- Instrumentation, modality selection, and documentation -- Conducting the gynecologic ultrasound examination -- Relevant pelvic anatomy -- Adenomyosis -- Congenital uterine anomalies -- Adnexal masses -- Menopausal dilemmas: how ultrasound has changed clinical management -- Lower urinary tract -- Early pregnancy -- Pregnancy failure -- Ectopic pregnancy -- Infertility -- Sonohysterography -- Ultrasound-guided procedures in gynecology -- Color doppler mapping in gynecology -- Transvaginal sonography and ovarian cancer -- Three-dimensional ultrasound in gynecology -- Ultrasound-enhanced bimanual examination -- Differential diagnosis of inflammatory diseases of the pelvis -- Pearls and pitfalls of transvaginal sonography.
- 2005 Thieme BookBahlmann, F.; Merz, Eberhard; Telger, Terry C.v. 1: ObstetricsAlso available: Print – v. 1-, 2005-
- 2015 SpringerGartman, Eric; Jankowich, Matthew.Ultrasound in the Intensive Care Unit explores the current state of evidence supporting use of bedside ultrasound for procedural guidance and for the critical care-focused assessment of a variety of organ systems. This text covers standard practice areas, such as ultrasound guidance for vascular access in the ICU, as well as novel, less well-known applications such as the use of ultrasound for assessment of diaphragm function in patients with respiratory failure. As current ultrasound education is often dependent on widely varying local expertise, this book serves as a standard reference in what is at present a fragmented and challenging field of study for busy clinicians. By providing a comprehensive overview of the current state of critical care ultrasonography, with content contributed by experts in the field, this text will serve as a valuable resource that will allow education in critical care ultrasound to keep pace with the rapid technological growth that has driven this vital area of critical care medicine. Ultrasound in the Intensive Care Unit is essential reading for pulmonologists, practitioners in internal, hospitalist, and critical care medicine; educators and instructors in critical care ultrasound; and medical students, residents, and critical care trainees.
- 2013King, Randy L.; Newsome, William T.; Pauly, Kim Butts; Pelc, Norbert J.Ultrasound-induced neurostimulation has recently gained increasing attention. Developments in the use of ultrasound to stimulate and modulate neural activity have raised the possibility of using ultrasound as a new investigative and therapeutic tool in brain research. Little is known about the mechanisms by which it affects neural activity or about the range of acoustic parameters and stimulation protocols that elicit responses. In this thesis, conditions are established for transcranial stimulation of the nervous system in vivo, using the mouse somatomotor response. It is reported that (1) continuous-wave stimuli are as effective as or more effective than pulsed stimuli in eliciting responses, and responses are elicited with stimulus onset rather than stimulus offset; (2) stimulation success increases as a function of both acoustic intensity and acoustic duration; (3) interactions of intensity and duration suggest that successful stimulation results from the integration of stimulus amplitude over a time interval of 50 to 150 ms; (4) the motor response elicited appears to be an all-or-nothing phenomenon, meaning stronger stimulus intensities and durations increase the probability of a motor response without affecting the duration or strength of the response; and (5) motor responses, measured by normalized EMG signals in the neck and tail regions, change signifcantly when sonicating rostral and caudal regions of the mouse motor cortex. Taken together our findings present good evidence for being able to target selective parts of the motor cortex with ultrasound neurostimulation in the mouse, steps that should provide encouragement for the development of new applications in larger animal models, including humans.
- 2008 ClinicalKeyBenacerraf, Beryl R.This book on prenatal diagnosis details the most common sonographically detectable fetal syndromes. It has an easy-to-follow approach of using lists and patterns of malformations to generate a differential diagnosis of the possible syndrome involved. The reader is then led to the more detailed description of each syndrome to determine the exact final diagnosis. The new edition incorporates 3D ultrasound throughout the book, as well as 20 syndromes not previously covered.
- 2007 SpringerBianchi Porro, Gabriele; Maconi, Giovanni.
- 2014 SpringerBianchi Porro, Gabriele; Maconi, Giovanni.This is the second, updated and extended edition of a well-received book that offers a comprehensive overview of ultrasonographic imaging of acute and chronic gastrointestinal diseases, including acute abdomen, appendicitis, diverticulitis, inflammatory bowel diseases, neoplasms and masses, infections, malabsorption syndromes, and rare conditions. The value of ultrasound in each disorder is clearly explained and illustrated, and limitations identified. Information is also provided on recent technical developments and ultrasound applications that are likely to become of increasing importance, such as functional and 3D ultrasound, contrast agents and intraoperative ultrasound, elastography, and transperineal ultrasound. The authors are all distinguished experts in the topics they address. Ultrasound of the Gastrointestinal Tract will be a helpful guide in daily practice not only for radiologists but also for gastroenterologists, abdominal surgeons, pediatricians, and oncologists.
- 2015 SpringerGilbert, Bruce R.History of Ultrasound -- Embryology Relevant to Ultrasound Imaging of the Male Genitalia -- Physical Principles of Ultrasound of the Male Genitalia -- Scrotal Ultrasound -- Penile Ultrasound -- Urology Ultrasound Practice Accreditation -- Genital Ultrasound Protocols: Putting it all Together!.
- 2007 SpringerBianchi, S.; Martinoli, C.
- 2012 SpringerAhuja, Anil T.; Sofferman, Robert A.Section I. History and Basic Concepts -- The History of Clinical Ultrasound -- Physics and Principles of Ultrasound -- Practical Concepts of Ultrasound -- Section II. Thyroid and Parathyroid Glands -- Sonography of the Normal Thyroid -- Benign Thyroid Conditions -- Malignant Thyroid Conditions -- Ultrasound Surveillance -- Parathyroid Ultrasound -- Fine Needle Aspiration Cytology -- Section III. Lymph Nodes and the Neck -- Lymph Nodes -- Benign Clinical Conditions in the Adjacent Neck -- Section IV. New Advances in Applied Ultrasound -- Thyroid Elastography -- Percutaneous Ethanol Injection for Thyroid and Parathyroid Disorders -- Contrast Enhanced Ultrasound and Ultrasound-Guided Minimally Invasive Therapy for the Diagnosis and Treatment of Focal Thyroid Lesions.
- 2006 Thieme BookBaxter, Grant M.; Sidhu, Paul S.Nephrology -- Introduction: medical overview -- Normal kidney -- Parenchymal diseases of the kidney -- Chronic renal failure -- Renal transplantation -- Radiological intervention in the urogenital tract (including trauma and emergencies) -- Urology -- Urogenital tract: surgical overview -- Focal lesions of the kidney -- Diseases of the collecting system and ureters -- Diseases of the bladder and prostate -- Diseases of the testis and epididymis -- Diseases of the penis with functional evaluation -- Oncological management of tumors of the urogenital tract -- Urogenital tract in the child -- Ultrasound of the pediatric urogenital tract -- Other imaging modalities in the urogenital tract -- Non-ultrasound imaging of the urogenital tract -- New developments: ultrasound contrast agents -- Native kidney -- Transplant kidney.
- 2007 Thieme BookBeuscher-Willems, B.; Schmidt, Guenter.Basic physical and technical principles -- The ultrasound examination -- Ultrasound documentation and reporting -- Function studies -- Interventional ultrasound -- Principal signs and symptoms -- Arteries and veins -- Cervical vessels -- Liver -- Kidney and adrenal gland -- Pancreas -- Spleen -- Bile ducts -- Gallbladder -- Gastrointestinal tract -- Urogenital tract -- Thorax -- Thyroid gland -- Major salivary glands -- Postoperative ultrasound -- Search for occult tumors.
- 2016 ClinicalKeyHertzberg, Barbara S.; Middleton, William D.This best-selling volume in The Requisites Series provides a comprehensive introduction to timely ultrasound concepts, ensuring quick access to all the essential tools for the effective practice of ultrasonography. Comprehensive yet concise, Ultrasound covers everything from basic principles to advanced state-of-the-art techniques. This title perfectly fulfills the career-long learning, maintenance of competence, reference, and review needs of residents, fellows, and practicing physicians. Covers the spectrum of ultrasound use for general, vascular, obstetric, and gynecologic imaging.
- 2014 SpringerTorzilli, Guido.Ultrasound guidance of liver surgery is a very sophisticated approach that permits the performance of otherwise unfeasible operations, discloses the true extent of tumors, increases the indications for hepatectomy, and renders surgery safer. Despite this, it has remained relatively neglected in the literature over the past two decades, during which time much progress has been achieved. This is the first atlas on the subject, and it is comprehensive in scope. The state of the art in the use of ultrasound for resection guidance is carefully documented, and new techniques for exploration of the biliary tract and facilitation of transplant surgery are presented. Further important topics include the role of ultrasound in laparoscopic approaches, the use of contrast agents for diagnosis and staging, and developments in the planning of surgical strategy. The editor is a leading authority whose group has been responsible for a variety of advances in the field. He has brought together other experts whose aim throughout is to provide clear information and guidance on the optimal use of ultrasound when performing liver surgery. This atlas is intended especially for hepatobiliary surgeons but will also be of considerable value for general surgeons.
- 2015 SpringerOrlandi, Davide; Sconfienza, Luca Maria; Silvestri, Enzo.
- 2012 SpringerSconfienza, Luca Maria; Serafini, Giovanni; Silvestri, Enzo.pt. 1. General Aspects of US-guided Musculoskeletal Procedures -- General Aspects of US-guided Musculoskeletal Procedures / Armando Conchiglia, Lorenzo Maria Gregori, Luigi Zugaro and Carlo Masciocchi -- pt. I. The Shoulder -- The Shoulder: Focused US Anatomy and Examination Technique / Enzo Silvestri and Davide Orlandi -- Subacromial-Subdeltoid Bursa Injections / Enzo Silvestri -- Treament of Calcific Tendinitis of the Rotator Cuff / Giovanni Serafini and Luca Maria Sconfienza -- Calcific Enthesopathy Dry-Needling / Francesca Lacelli -- Hyaluronic Supplementation of the Subacromial Space / Giovanni Serafini -- Intra-articular Injections / Francesca Lacelli -- Long Head of the Biceps Brachii Tendon Injection / Luca Maria Sconfienza -- Acromioclavicular Joint Injection / Enzo Silvestri -- pt. II. The Elbow -- The Elbow: Focused US Anatomy and Examination Technique / Enzo Silvestri and Emanuele Fabbro -- Treatment of Lateral Epicondylitis / Giovanni Serafini -- Treatment of Medial Epicondylitis / Enzo Silvestri -- Olecranon Bursa Drainage / Francesca Lacelli -- Intra-articular Injections / Luca Maria Sconfienza -- pt. III. The Wrist -- The Wrist: Focused US Anatomy and Examination Technique / Enzo Silvestri and Giulio Ferrero -- Treament of De Quervain's Disease and Other Forms of Tenosynovitis / Giovanni Serafini -- Articular Ganglia Drainage / Leonardo Callegari -- Trapeziometacarpal Joint Injection / Francesca Lacelli -- Radiocarpal Joint Injections / Luca Maria Sconfienza -- pt. IV. The Hand -- The Hand: Focused US Anatomy and Examination Technique -- Francesca Lacelli and Chiara Martini -- Treatment of Trigger Finger / Leonardo Callegari -- Intra-articular Injections: Metacarpophalangeal and Interphalangeal Joints / Luca Maria Sconfienza.
- 2010 Thieme BookDogra, Vikram; Saad, Wael E. A.This handbook is a practical reference for the full range of common and complex ultrasound-guided procedures frequently performed in clinical practice. Divided into four sections, this book provides in-depth guidelines from renowned specialists for how to perform ultrasound-guided biopsies, how to utilize ultrasound to obtain access for interventional procedures and perform drainage, and how to perform ultrasound-guided percutaneous therapy and sonohysterography. Detailed coverage of such key procedures as thyroid biopsy, breast biopsy, sonohysterography, superficial lymph node biopsy, musculoskeletal interventions, and more. Concise bullet-point format that aids rapid reading and review of indications, contraindications, equipment, technique and post-procedural evaluation and possible complications and their management. More than 600 high-quality images and illustrations that clarify complex concepts.
- Bigeleisen, Paul E.; Gofeld, Michael; Orebaugh, Steven L.
- 2005 KargerDvorak, Ann M.Also available: Print – 2005
- v. 2, 1953-.Neumann, Erich.-- v. 2. Zur Psychologie des Weiblichen.
- 2006 CRCnetBASERhem, Anthony J.
- 2013 ClinicalKeyUmphred, Darcy Ann.Section I. Foundations for clinical practice in neurological rehabilitation. Foundations for clinical practice / Darcy A. Umphred, Rolando T. Lazaro and Margaret L. Roller -- Health and wellness: The beginning of the paradigm / Janet R. Bezner -- Movement analysis across the life span / Dale Scalise-Smith and Darcy A. Umphred -- Contemporary issues and theories of motor control, motor learning, and neuroplasticity / Margaret L. Roller ... [et.al.] -- The limbic system : Influence over motor control and learning / Darcy A. Umphred, Marcia Hall Thompson and Therese Marie West -- Psychosocial aspects of adaptation and adjustment during various phases of neurological disability / Rochelle McLaughlin and Gordon U. Burton -- Differential diagnosis phase 1 : Medical screening by the therapist / William G. Boissonnault and Darcy A. Umphred -- Differential diagnosis phase 2 : Examination and evaluation of functional movement activities, body functions and structures, and participation / Rolando T. Lazaro, Margaret L. Roller and Darcy A. Umphred -- Interventions for clients with movement limitations / Darcy A. Umphred ... [et.al.] -- Payment systems for services : Documentation through the care continuum / Barbara Edmison and John G. Wallace, Jr. -- Section II. Rehabilitation management of clients with neurological system pathology. Neonates and parents : Neurodevelopmental perspectives in the neonatal intensive care unit and follow-up / Jane K. Sweeney, Teresa Gutierrez and Joanna C. Beachy -- Management of clinical problems of children with cerebral palsy / Claudia R. Senesac -- Genetic disorders : A pediatric perspective / Sandra G. Bellamy and Eunice Yu Chiu Shen -- Learning disabilities and developmental coordination disorder / Stacey E. Szklut and Darbi Breath Philibert -- Spina bifida : A congenital spinal cord injury / Kristin J. Krosschell and Mari Jo Pesavento -- Traumatic spinal cord injury / Myrtice B. Atrice ... [et.al.] -- Neuromuscular diseases / Ann Hallum and Diane D. Allen -- Beyond the central nervous system : Neurovascular entrapment syndromes / Bradley W. Stockert, Laura J. Kenny and Peter I. Edgelow -- Multiple sclerosis / Gail L. Widener -- Basal ganglia disorders / Marsha E. Melnick -- Movement dysfunction associated with cerebellar damage / Susanne M. Morton and Amy J. Bastian -- Balance and vestibular dysfunction / Leslie K. Allison and Kenda Fuller -- Movement dysfunction associated with hemiplegia / Susan D. Ryerson -- Traumatic brain injury / Patricia A. Winkler -- Brain tumors / Corrie J. Stayner, Rachel M. Lopez and Karla M. Tuzzolino -- Inflammatory and infectious disorders of the brain / Judith A. Dewane -- Aging, dementia, and disorders of cognition / Osa Jackson Schulte, James Stephens and Joyce Ann -- Section III. Neurological disorders and applications issues. Disorders of vision and visual-perceptual dysfunction / Laurie Ruth Chaikin -- Pelvic floor treatment of incontinence and other urinary dysfunctions in men and women / Beate Carriere -- Cardiovascular and pulmonary system health in populations with neurological disorders / Marilyn Mackay-Lyons -- Human immunodeficiency virus infection : Living with a chronic illness / Kerri Sowers, Mary Lou Galantino and David M. Kietrys -- Pain management / Annie Burke-Doe -- Electrophysiological testing and electrical stimulation in neurological rehabilitation / Alain Claudel ... [et.al.] -- Orthotics : Evaluation, intervention, and prescription / Heidi Truman and Walter Racette -- Management of chronic impairments in individuals with nervous system conditions / Myla U. Quiben -- Impact of drug therapy on patients receiving neurological rehabilitation / Annie Burke-Doe and Timothy J. Smith -- Use of medical imaging in neurorehabilitation / Rolando T. Lazaro and Darcy A. Umphred -- Integrating technology into clinical practice in neurological rehabilitation / Katie Byl ... [et.al.] -- Complementary and alternative therapies : Beyond traditional approaches to intervention in neurological diseases and movement disorders / Darcy A. Umphred, Carol M. Davis and Mary Lou Galantino.
- Uncemented femoral stems for revision surgery : the press-fit concept - planning - surgical technique - evaluation2015 SpringerLe Béguec, Pierre.Part I: Press-Fit Concept -- Uncemented Concepts: Parameters to Make a Choice -- The Press-Fit Concept: Principles and Press-Fittable Zones -- The Press-Fit Concept: Practical Application -- The Press-Fit Concept: Implants And Instruments -- Part II: Preoperative Planning -- Radiographic Analysis Of The Femur -- Selection of a Strategy -- Making a Preoperative Template -- Part III: Surgical Technique -- Trochantero-Diaphyseal Femoral Flap -- Femoral Flap and Diaphyseal Primary Fixation -- Endofemoral Approach and Proximal Primary Fixation -- Part IV: Evaluation of the Radiographic Results -- General Considerations -- A-Evaluation of the Radiographic Results ? How? -- Evaluation of Initial and Secondary Bone Stock -- Evaluation of Osseointegration and Secondary Stability -- Global Radiographic Score -- Comparative Elements with the Engh Score -- Part V: Evaluation of the Radiographic Results -- Why? -- The Learning Curve and its Teachings -- Different Types of Primary Stability: Their Impact on the Radiographic Results -- Degree of Osteoporosis: Its Impact on the Radiographic Results -- Affected Initial Bone Stock: Its Impact on the Radiographic Results -- Parameters to Improve Radiographic Results -- Complications and Contraindications -- Numerical Evaluation and Comparative Analysis of Results -- General Conclusions: What You Should and What You Should not Do.
- 2008 WHOPart 1: Guidance document on characterizing and communicating uncertainty in exposure assessment -- Part 2: Hallmarks of data quality in chemical exposure assessment.Also available: Print – 2008
- 2006 CRCnetBASEAyyub, Bilal M.; Klir, George J.
- 2008Bogousslavsky, Julien; Caplan, Louis R.
- 2014 SpringerLeone, Marc; Martin, Claude; Vincent, J. L.This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.
- 2013 SpringerBassi, C.; Pederzoli, P.Cystic Pancreatic Neoplasms -- Classification / Giuseppe Zamboni -- Serous Cystic Neoplasms / Giuseppe Malleo, Giuseppe Zamboni, Marina Paini, Giovanni Marchegiani -- Mucinous Cystic Neoplasms / Giovanni Marchegiani, Riccardo Manfredi, Giuseppe Malleo, Isabella Frigerio -- Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms / Marina Paini, Giuseppe Zamboni, Riccardo Manfredi, Salvatore Paiella, Giuseppe Malleo -- Intraductal Papillary Mucinous Neoplasms / Isabella Frigerio, Giuseppe Zamboni, Riccardo Manfredi, Antonio Pea, Silvia Pennacchio -- The Role of the Oncologist in the Diagnosis and Management of Malignant Cystic Neoplasms / Alessandra Auriemma, Davide Melisi, Giampaolo Tortora -- Neuroendocrine Pancreatic Neoplasms -- Epidemiology and Clinical Presentation / Maria Vittoria Davì, Marco Toaiari, Giuseppe Francia -- Pathology and Genetics / Aldo Scarpa, Vincenzo Corbo -- Imaging / Roberto Pozzi Mucelli, Giovanni Foti, Luigi Romano -- Surgical Therapy / Rossella Bettini, Stefano Partelli, Stefano Crippa, Letizia Boninsegna, Massimo Falconi -- Functional Imaging and Peptide Receptor Radionuclide Therapy / Maria Chiara Ambrosetti, Duccio Volterrani, Federica Guidoccio, Lisa Bodei -- Targeted and Other Non-receptor-mediated Therapies / Sara Cingarlini, Chiara Trentin, Elisabetta Grego, Giampaolo Tortora -- Uncommon Pancreatic Solid Neoplasms -- Rare Variants of Ductal Adenocarcinoma of the Pancreas / Paolo Regi, Marco Dal Molin, Federica Pedica, Paola Capelli, Mirko D'Onofrio -- Rare Primary Tumors of the Pancreas / Marco Dal Molin, Paola Capelli, Mirko D'Onofrio, Ivana Cataldo, Giovanni Marchegiani -- Rare Secondary Tumors of the Pancreas / Giovanni Butturini, Marco Inama, Marco Dal Molin, Mirko D'Onofrio, Davide Melisi -- Primary Non-epithelial Tumors of the Pancreas / Marco Dal Molin, Paola Capelli -- Tumor-like Lesions of the Pancreas / Luca Frulloni, Antonio Amodio, Italo Vantini, Marco Dal Molin, Marco Inama.
- 2012Schaich Borg, Jana; De Lecea, Luis; Fernald, Russell D.; Knutson, Brian; Newsome, William T.; Parker, Karen J.Over half of all violent crimes are committed by only about 5% of offenders. While most healthy people feel strong aversion to seeing other people in pain, fear, or sadness, a phenomenon I define as "negative intersubjectivity", these persistent violent offenders (PVOs) have blunted reactions to other people's distress and the strength of their negative intersubjectivity deficit correlates with how much violence they ultimately perform. This suggests that if we could learn how to enhance PVOs aversion to other people's distress, we could decrease their violent behavior. In this dissertation, I describe a new rat model that can be used to study the neural mechanisms underlying negative intersubjectivity. I demonstrate that Observer rats will overcome their innate aversion of bright light to consistently avoid a dark, safe space if entering that dark space is paired with another Receiver rat getting shocked, a behavior called "intersubjective avoidance". In Chapter 2, I describe the relatively poor intersubjective avoidance behavior of mice. In Chapter 3, I describe the comparatively strong intersubjective avoidance behavior of rats, and show that rats' intersubjective avoidance is enhanced by personal experience with shock. In Chapter 4, I use patterns of expression of the immediate early gene c-Fos to determine whether activity in candidate brain regions correlates with intersubjective avoidance. I provide evidence that many brain regions--including the anterior cingulate, anterior insula, infralimbic cortex, and central amygdala--are active both when observing shock in another and when receiving shock to oneself, similar to what has been shown by fMRI studies of humans observing others in pain. However, within these areas, only activity in the anterior cingulate robustly correlates with how much intersubjective avoidance each individual Observer rat performs, perhaps analogous to how fMRI studies in humans have show that anterior cingulate activity correlates with humans' self-reports of "empathy". These results validate the rat model of intersubjective avoidance as model of negative intersubjectivity in humans, and highlight the anterior cingulate as a potential target for negative intersubjectivity interventions. In Chapter 5, I describe future experiments and discuss how research using this new behavioral paradigm may help develop treatments for not only PVOs, but all anti-social behavior.
- Under doctors' eyes : private life in Russian literature in the first half of the nineteenth century2012Neklyudova, Ekaterina; Freidin, Gregory; Greenleaf, Monika; Safran, Gabriella.My dissertation deals with the figure of the doctor in early Russian nineteenth-century prose, which manifests a shift in the way literature depicts human physicality and the characters' everyday life. My major source is 1820s-1840s prose, mostly published in the literary and cultural journals Biblioteka dlia Chtenia, Syn Otechestva, and others. My sources reflect the impressive expansion in Russian literature and medicine in the first quarter of the nineteenth century. Using documentary and literary sources, I demonstrate that the artistic representation of physicians in Romantic and Realist prose contributes to the introduction of previously unknown themes into literature: medical perspectives on physical suffering, the private everyday lives of ordinary people, and even the mystical view of other worlds. The combination of medical and mystical discourses in the vocabulary of real doctors in the first half of the nineteenth century gave them the authority to judge human bodies, lives, and, they believed, souls: they seemed to observe from inside and outside at the same time. By including a doctor among their characters, fiction writers thus could use a powerful instrument that let them introduce new topics. As I show, through the mid nineteenth century, the fictional doctors situated at the margin of literary plots performed the role of an important textual device: they served as go-betweens among other characters, mediating, connecting or splitting them. They affected the relationship between characters, the plot's trajectory, and the readers' perception. The situation shifts in mid century; with the gradual separation of doctor from his instrumental function, this character moves to the center of the plot and loses his structural power.
- 2008 SpringerBonk, Thomas.
- 2012Brase, Charles Henry; Brase, Corrinne Pellillo.1. Getting Started -- 2. Organizing Data -- 3. Averages and Variation -- 4. Elementary Probability Theory -- 5. The Binomial Probability Distribution and Related Topics -- 6. Normal Curves and Sampling Distributions -- 7. Estimation -- 8. Hypothesis Testing -- 9. Correlation and Regression -- 10. Chi-Square and F Distributions -- 11. Nonparametric Statistics.
- 2015 SpringerEl-Salhy, Magdy; Hatlebakk, Jan Gunnar; Hausken, Trygve.1. Irritable bowel syndrome: what is it? -- 2. The digestive tract and how it works -- 3. The cause of irritable bowel syndrome -- 4. How is irritable bowel syndrome diagnosed? -- 5. Treatment options without medication -- 6. Treatment options involving medication -- 7. There is a light at the end of the tunnel.
- 2010Whitman, Chad Michael; Du Bois, Justin; Khosla, Chaitan; Kohler, Jennifer.The mammalian cell surface is comprised of a heterogenous mixture of proteins and lipids decorated by carbohydrates. These molecules are known as glycoconjugates. Among the many types of glycolipids imbedded within the plasma membrane is a class of negatively charged species known as gangliosides. Gangliosides, which are characterized by the presence of sialic acid residues, are responsible for regulating the activity of many cell surface proteins and serve as recognition targets for cell-cell communication and pathogen invasion. To investigate the biological roles of gangliosides in mammalian cells, I have employed metabolic oligosaccharide engineering techniques to introduce small structural changes into sialic acid residues. Using these methods, I have successfully demonstrated the biosynthesis of photocrosslinking gangliosides in mammalian cells. These photocrosslinking gangliosides can be used to capture and isolate transient ganglioside-mediated interactions in their native environment. I have also used metabolic engineering techniques to probe the substrate selectivity of ganglioside sialyltransferases in mammalian cells. My results illustrate significant differences in the ability of different cell lines to metabolize sialic acid analogs; these differences may be due species-specific variations in sialyltransferase specificity.
- 2012Sim, Yen Ling Adelene; Doniach, S.; Herschlag, Daniel; Levitt, Michael.RNA is an important biological macromolecule that carries out a variety of roles in the cell. To function, RNA needs to fold into precise three-dimensional structures. Different physical forces like entropy, base-pairing and stacking interactions, tertiary contacts and electrostatics affect this folding process. In the first part of this thesis, we focus on nucleic acid electrostatics; RNA molecules have negatively charged backbones that require counterions to neutralize charge-repulsion and facilitate folding. We discuss the ion conditions necessary for a riboswitch (gene-regulating RNA found on 5' or 3' ends of messenger RNA) folding, studied how the flexibility of single stranded DNA is affected by the presence of different amounts of counterions and present a benchmark experimental dataset that can be used for direct comparison to electrostatic theories. The second part of the thesis deals with computational and analysis tools developed to model and understand nucleic acid systems with the ultimate goal of being able to predict RNA structure. Since RNA typically folds hierarchically, we devised a general hierarchical sampling protocol that naturally explores RNA three-dimensional conformational space efficiently and can be used in concert with any force field, such as an RNA knowledgebased potential that we also discuss in this thesis. Additionally, we examined a clustering method that can assist analysis of structural models. Lastly, we applied our modeling techniques to study simple two-way RNA junctions with all-atom representation, and probed the modeled effects of sterics, chain connectivity and sequence on dynamic RNA behavior.
- Understanding and preventing anterior cruciate ligament injuries using novel motion analysis systems2011Dowling, Ariel Veronica; Andriacchi, Thomas P.; Cutkosky, Mark R.; Giori, Nicholas John.The overall goal of this dissertation is to use novel motion analysis systems to investigate the underlying mechanisms that cause an anterior cruciate ligament (ACL) injury and then to explore movement modification methods that might prevent ACL injuries from occurring. Additionally, novel motion analysis systems can provide new information about ACL injuries and therefore should be used to help analyze these injuries from a different perspective. This thesis provides the results from multiple experimental studies that used two novel motion analysis systems to investigate the underlying causes of ACL injury and potential injury prevention methods. Using a markerless motion capture system, the first investigation determined that increasing the coefficient of friction of the shoe-surface condition will change a subject's movement strategies during a sidestep cutting task in specific ways that may increase the risk of ACL injury. This investigation provides a biomechanical basis for the increased incidence of ACL injuries on high friction surfaces, and suggests that females are more at risk for ACL injury when cutting on high friction surfaces. In terms of novel motion analysis systems, there is a need for simple, cost effective methods to identify athletes at a higher risk for ACL injury during jumping tasks. As such, the second study assessed the capacity of a wearable inertial-based system to evaluate ACL injury risk during jumping tasks. The proposed system measured the knee flexion angle and the trunk lean, and demonstrated good concurrent validity and discriminative performance in terms of the known risk factors for ACL injury. This study also reported the angular velocity of the thigh and shank segments during bilateral and unilateral drop jumps for the first time. Furthermore, this study illustrated that there is an association between the coronal segment angular velocity and knee abduction moment, and that the coronal segment angular velocity can differentiate between subjects at higher risk for ACL injury. Recent studies have shown that the incidence of ACL injury can be decreased through the use of intervention programs. Therefore, the objective for the final study was to determine if an independent inertial-based system can be used to modify jump landing mechanics in order to decrease the risk for ACL injury by providing real-time feedback based on known kinematic and kinetic injury risk factors. This study found that the subjects reduced their risk for ACL injury after training with the system because there were significant increases in the maximum knee flexion angle and the maximum trunk lean. The subjects also reduced their risk for injury by decreasing their thigh coronal angular velocity, which was correlated with a decrease in their knee abduction moment. This study suggests that an inertial-based system could be used for interventional training aimed at reducing the risk for ACL injury.
- 2006 CRCnetBASEHaslam, Roger; Stubbs, David.
- 2013 OSO, Limited to 3 simultaneous usersZiebland, Sue.Improving patient experience is a global priority for health policy-makers and care providers. This book critically examines the various ways in which people's experience of health and healthcare can be recorded, analysed and therefore improved.
- 2014 WHO"Surveillance data collected in vital registration and TB notification systems provide essential information about the TB epidemic and programmatic efforts to control the disease at both national and local levels. Analysis of these data can help programme managers and other staff to track the level of and trends in TB disease burden, detect outbreaks of disease and identify ways to improve existing TB prevention, diagnostic and treatment services. This book provides practical guidance on the analysis and use of such surveillance data, and is suitable for a wide range of people engaged in TB control. It was produced as a major collaborative effort as part of the work of the WHO's Global Task Force on TB Impact Measurement."-- back cover.Also available: Print – 2014
- Understanding antimicrobial exposure and clostridium difficile infection : implications of fluoroquinolone use2008Bartlett, John G.; Gerding, Dale N.PrintLane Catalog Record
- pt. 1-2, 2008Cerutti, Sergio; Mainardi, Luca; Sörnmo, Leif.
- 2006 CRCnetBASEMoldin, Steven O.; Rubenstein, John L. R.Integrating basic and clinical neuroscience perspectives, this book presents a comprehensive perspective on state-of-the-art research in epidemiology, genetics, and clinical neuroscience and neural systems implicated in autism. This book seeks to stimulate new directions for autism research on etiology, pathophysiology, and the development of new drug treatment. An underlying theme focuses on the potential for future research given the availability of the human, mouse, and other genomes. The text also explores the role of autism in society, including health economics and advocacy issues of interest to legislators.
- 2008Zvelebil, Marketa J.; Baum, Jeremy O.PrintLane Catalog Record
- 2006 SpringerBlondelle, Sylvie E.
- Understanding biomechanical causes and functional mechanism of treatment for stiff-knee gait in cerebral palsy2011Fox, Melanie Diane; Andriacchi, Thomas P.; Delp, Scott; Rose, Jessica.Many children with cerebral palsy walk with a stiff knee gait, or a reduction and delay in swing phase knee flexion, which causes tripping or energy-inefficient compensatory movements. Since over-activity of the rectus femoris muscle is frequently implicated as the cause, a common treatment is transfer of the distal end of the rectus femoris from its insertion on the patella to a location behind the knee. Outcomes, though positive on average, vary among individuals, with some patients demonstrating unimproved or worsened knee flexion postoperatively. This variability is due in part to insufficient understanding of the biomechanical causes of stiff-knee gait and the functional effects of surgical treatment. The goal of this dissertation was to clarify the causes of stiff-knee gait and examine the biomechanical mechanism of improvement following rectus femoris transfer surgery. Swing-phase rectus femoris activity is commonly thought to cause of stiff-knee gait, despite evidence that many patients have excessive knee extension moments in preswing rather than swing phase. We compared the effects of preswing to swing phase activity of the rectus femoris on peak knee flexion in swing by creating and analyzing musculoskeletal simulations of subjects with stiff-knee gait. We found that in six out of ten subjects preswing rectus femoris activity had at least a 90% higher effect on peak knee flexion than swing phase rectus femoris activity, suggesting that preswing rectus femoris activity is an important factor limiting knee flexion in some subjects and should be examined to better determine the factors leading to stiff-knee gait. To understand how other muscles, besides rectus femoris, may limit knee flexion in stiff-knee gait, it is first necessary to understand how muscles coordinate successful swing phase knee flexion in unimpaired gait and how muscle contributions change with walking speed, since many stiff-knee subjects walk slowly. We analyzed simulations of unimpaired subjects walking at different speeds to determine the muscles that accelerated and decelerated knee flexion prior to swing. We found that preswing knee flexion acceleration was achieved primarily by the hip flexor muscles with help from biceps femoris short head, suggesting that weakness in these muscles may contribute to stiff-knee gait. Vasti and soleus decelerated knee flexion, suggesting over-activity in these muscles may contribute to stiff-knee gait. We also investigated the mechanism of improvement following rectus femoris transfer surgery. We altered the geometry of rectus femoris and simulated the dynamics of the swing phase of subjects with stiff-knee gait after different surgical procedures. Analysis of the simulations demonstrated that knee flexion may be improved with a reduction of the knee extension moment generated by the rectus femoris, even if the muscle is not converted to a knee flexor. This dissertation clarifies preswing rectus femoris activity as a cause of stiff-knee gait, demonstrates the functional mechanism of improvement following transfer surgery, and informs future research investigating other potential contributors to stiff-knee gait.
- 2006Kiaris, Hippokratis.Some introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue.
- 2014 ebraryBowers, David.Understanding Clinical Papers is a popular and well established introduction to reading clinical papers. It unravels the process of evidence-based practice, using real papers to illustrate how to understand and evaluate published research, and provides clear explanations of important research-related topics.
- 2013 AccessMedicineHarrington, Robert A.; Lopes, Renato D.Complete how-to guidance on conducting clinical research, this book addresses the operational challenges of clinical trials and provides a clear explanation of the methodologies necessary to interpret results. The book addresses all aspects of clinical trials, from design and implementation to statistics to regulatory scrutiny. A resource for students, residents, and clinicians who need a working knowledge of clinical research principles. The chapter authors are all leaders in the field and engaged in cutting edge clinical research. Use as a textbook, as a reference, and as a course guide for mandated clinical research training courses.
- 2007 CRCnetBASEFrewer, Lynn; Trijp, Hans van.pt. 1. Key influences on consumer food choice -- pt. 2. Product attributes and consumer food choice -- pt. 3. Diversity in consumer food choice: cultural and individual difference -- pt. 4. Consumers, food and health -- pt. 5. Consumer attitude, food policy and practice.
- 2014 KargerAhmed, S. F.; Hiort, O.Gonadal development / Lucas-Herald, A.K., Bashamboo, A. -- The masculinization programming window / Welsh, M., Suzuki, H., Yamada, G. -- Androgen action / Werner, R., Holterhus, P.-M. -- Steroid biochemistry / Kamrath, C., Wudy, S.A., Krone, N. -- Next generation sequencing for disorders of sex development / Tobias, E.S., McElreavey, K. -- Advances in neuroimaging / Rodie, M.E., Forbes, K.P., Muir, K. -- Imaging, endoscopy and diagnostic surgery / Wünsch, L., Buchholz, M. -- Fertility issues in the management of patients with disorders of sex development / Guercio, G., Rey, R.A. -- Disorders of sex development peer support / Baratz, A.B., Sharp, M.K., Sandberg, D.E. -- Improving the communication of healthcare professionals with affected children and adolescents / Nordenström, A., Thyen, U. -- Working with adolescents and young adults to support transition / Gleeson, H., Wisniewski, A.B. -- Past experiences of adults with disorders of sex development / GrApSIA, Audí, L. -- Sex hormone replacement in disorders of sex development / Birnbaum, W., Bertelloni, S. -- Hydrocortisone replacement in disorders of sex development / Blankenstein, O. -- Advances in molecular markers of germ cell cancer in patients with disorders of sex development / van der Zwan, Y.H., Cools, M., Looijenga, L.H.J. -- Managing the risk of germ cell tumourigenesis in disorders of sex development patients / Cools, M., Looijenga, L.H.J., Wolffenbuttel, K.P., T'Sjoen, G. -- Timing of hypospadias repair in patients with disorders of sex development / Springer, A., Baskin, L.S. -- Timing of surgery for feminizing genitoplasty in patients suffering from congenital adrenal hyperplasia / Eckoldt-Wolke, F. -- Timing of feminising surgery in disorder of sex development / Wolffenbuttel, K.P., Crouch, N.S. -- Phalloplasty : a panacea for 46,XY disorder of sex development conditions with penile deficiency? / Callens, N.; Hoebeke, P. -- Rare diseases research and practice / Polizzi, A., Balsamo, A., Bal, M.O., Taruscio, D. -- Achieving diagnostic certainty in resource-limited settings / Mazen, I., Raza, J. -- Global application of disorders of sex development-related electronic resources : e-learning, e-consultation and e-information sharing / Muscarella, M., Kranenburg-van Koppen, L., Grijpink-van den Biggelaar, K., Drop, S.L.S. -- International networks for supporting research and clinical care in the field of disorders of sex development / Ahmed, S.F., Bryce, J., Hiort, O.
- 2007 CRCnetBASEGrassi, Mario.Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes.
- 2006 ScienceDirectAnders, S.
- Understanding evidence-based rheumatology : a guide to interpreting criteria, drugs, trials, registries, and ethics2014 SpringerLesaffre, Emmanuel; Yazıcı, Hasan; Yazıcı, Yusuf.It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics, and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology, and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined, and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, experienced clinicians, and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.
- Understanding fluorescein angiography = : Fluoreszeinangiografie verstehen = Entendiendo angiografía con fluoresceína2006 SpringerSpitznas, Manfred.Also available: Print – 2006
- 2014 AccessMedicineFisher, Melanie A.; Markle, William H.; Smego, Raymond A.Global health : past, present and future / Amir A. Khaliq and Raymond A. Smego, Jr. -- The global burden of disease / Thuy D. Bui and William H. Markle -- Epidemiology, biostatistics, and surveillance / Christopher Martin -- The health of women/mothers and children / Judy Lewis, Monika Doshi, Deyanira Gonzalez de Leon, and Amany Refaat -- Human trafficking / Clydette Powell -- Environmental health in the global context / Jeffrey K. Griffiths and Edward Winant -- Nutrition / Clydette Powell and John R. Butterly -- Primary care in global health / Jeffrey F. Markuns and Alain J. Montegut -- Malaria / Paul R. Larson and Mark W. Meyer -- Tuberculosis and HIV/AIDS / Lisa V. Adams and Godfrey B. Woelk -- The neglected tropical diseases / Gregory Juckett -- Emerging diseases and antimicrobial resistance / Arif R. Sarwari and Rashida A. Khakoo -- Injury and global health / Jeffry P. McKinzie -- Surgical issues in global health / Eileen S. Natuzzi, et al. -- Humanitarian assistance and disaster relief / Sheri Fink, Vera Sistenich, and Clydette Powell -- Aging populations and chronic illness / Wayne A. Hale, Jane D. Joubert, and Sebastiana Kalula -- Global mental health : the world mental health surveys perspective / Jordi Alonso, Somnath Chatterji, Yanling He, Philip S. Wang, and Ronald C. Kessler -- Global health communications, social marketing, and emerging communication technologies / Gary Snyder -- Economics and global health / Kevin Chan -- Health systems, management, and organization in global health / David Zakus, Onil Bhattacharyya, and Xiaolin Wei -- Global health ethics / Anvar Velji and John H. Bryant -- Education and careers in global health / Jessica Evert and Scott Loeliger.
- Understanding health literacy and its barriers : January 1998 through November 2003, plus selected ear[l]ier and later citations : 651 citations2004 NLMZorn, Marcia; Allen, Marin Pearson; Horowitz, Alice M.Examines some of the barriers that may need to be addressed when designing strategies to connect the audience with appropriate health information materials, services, or resources.
- 2009Bodenheimer, Thomas; Grumbach, Kevin.
- 2012 AccessMedicineBodenheimer, Thomas; Grumbach, Kevin.Introduction: the paradox of excess and deprivation -- Paying for health care -- Access to health care -- Reimbursing health care providers -- How health care is organised--I: primary, secondary, and tertiary care -- How health care is organised--II: health delivery systems -- Health care workforce and the education of health professionals -- Painful versus painless cost control -- Mechanisms for controlling costs -- Quality of health care -- Prevention of illness -- Long-term care -- Medical ethics and rationing of health care -- Health care in four nations -- Health care reform and national health insurance -- Conflict and change in America's health care system -- Conclusion: tensions and challenges -- Questions and discussion topics.
- 2011Ooi, Ann Gee Lisa; Beachy, Philip Arden; Mitchell, Beverly S.; Rando, Thomas; Weissman, Irving L.; Wysocka, Joanna.Recent technological advances in high throughput technology, sample preparation and data analysis have made whole genome mRNA and miRNA analysis of purified hematopoietic cell populations much more accessible. The high throughput analysis of the hematopoietic stem cell (HSC) population has yielded massive amounts of data and now we are in the process of biologically validating these targets. Esam1 is one target yielded from microarray analysis of the HSC population. We found Esam1 to be highly and selectively expressed by HSC from mouse bone marrow. Esam1 is also a viable positive HSC marker in fetal, young and aged mice, as well as in mice of several different strains. In addition, we find robust levels of Esam1 transcripts in purified human HSC. Esam1-/- mice do not exhibit severe hematopoietic defects, however, Esam1-/- BM has an increased frequency of HSC and fewer T cells. HSC from Esam1-/- mice give rise to more granulocyte/monocytes in culture and a higher T cell:B cell ratio upon transplantation into congenic mice. These studies identify Esam1 as a novel, widely applicable HSC-selective marker and suggest that Esam1 may play roles in both HSC proliferation and lineage decisions. MicroRNA-125b (miR-125b) is a target yielded from miRNA profiling of the HSC population. We show that miR-125b is highly expressed in HSC and its expression decreases in committed progenitors. Overexpression of miR-125b in mouse HSC enhances their function, demonstrated through serial transplantation of highly purified HSC, and enriches for the previously described Slamf1lo CD34- lymphoid balanced and the Slamf1negCD34- lymphoid biased cell subsets within the multipotent HSC [CD34-KLS] fraction. This enrichment of HSC subsets occur via an anti-apoptotic mechanism, reducing the mRNA expression levels of two pro-apoptotic targets, Bmf and KLF13. The anti-apoptotic effect of miR-125b is more pronounced in the lymphoid biased HSC subset because of their intrinsic higher baseline levels of apoptosis. Together, these data reveal that miR-125b regulates hematopoietic stem cell survival and can promote lymphoid fate decisions at the level of the HSC by preferentially expanding lymphoid balanced and lymphoid biased HSC.
- 2014 SpringerCarr, Brian I.Understanding Liver Cancer is a concise and up-to-date review, which discusses diagnosis, management, patient care, current and emerging therapies, and useful resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of liver cancer as well as a summary of current therapies will benefit from this succinct text.
- Furrie, Betty.
- 2010 SpringerHasan, Ashfaq.Historical Aspects of Mechanical Ventilation / Ashfaq Hasan -- The Indications for Mechanical Ventilation / Ashfaq Hasan -- Physiological Considerations in the Mechanically Ventilated Patient / Ashfaq Hasan -- The Conventional Modes of Mechanical Ventilation / Ashfaq Hasan -- Ventilator Settings / Ashfaq Hasan -- Ventilator Alarms / Ashfaq Hasan -- Monitoring Gas Exchange in the Mechanically Ventilated Patient / Ashfaq Hasan -- Monitoring Lung Mechanics in the Mechanically Ventilated Patient / Ashfaq Hasan -- Mechanical Ventilation in Specific Disorders / Ashfaq Hasan -- The Complications of Mechanical Ventilation / Ashfaq Hasan -- Ventilator-Associated Pneumonia / Ashfaq Hasan -- Discontinuation of Mechanical Ventilation / Ashfaq Hasan -- Noninvasive Ventilation in Acute Respiratory Failure / Ashfaq Hasan -- Negative Pressure Ventilation / Ashfaq Hasan -- Airway Humidification in the Mechanically Ventilated Patient / Ashfaq Hasan -- Aerosol Therapy in the Mechanically Ventilated Patient / Ashfaq Hasan -- Nonconventional Modes and Adjunctive Therapies for Mechanical Ventilation / Ashfaq Hasan -- Case Studies / Ashfaq Hasan.
- 2008Chao, Daniel Lee.
- 2014 ebrarySwanwick, Tim.Understanding medical education / Tim Swanwick -- Teaching and learning in medical education: how theory can inform practice / David M Kaufman and Karen V. Mann -- Principles of curriculum design / Janet Grant -- Quality in medical education / Alan Bleakley, Julie Browne and Kate Ellis -- Problem-based learning / Mark A Albanese -- Interprofessional education / Della Freeth -- Work-based learning / Clare Morris and David Blaney -- Supervision, mentoring and coaching / John Launer -- Teaching and leading small groups / Peter McCrorie -- Lectures and large groups / Andrew Long and Bridget Lock -- Technology-enhanced learning / Alison Bullock and Peter de Jong -- E-learning / Scott Rice and Jean McKendree -- Simulation in medical education / Jean Ker and Paul Bradley -- Portfolios in personal and professional development / Erik Driessen and Jan van Tartwijk -- Self-regulated learning in medical education / Casey B. White, Larry D.Gruppen and Joseph C. Fantone -- Learning medicine from the humanities / J. Jill Gordon and H. Martyn Evans -- Patient involvement in medical education / John Spencer and Judy McKimm -- How to design a useful test: the principles of assessment / Lambert WT Schuwirth and Cees PM van der Vleuten -- Written assessment / Brian Jolly -- Workplace assessment / John J Norcini -- Structured assessments of clinical competence / Katharine A. M. Boursicot, Trudie E Roberts and William P Burdick -- Standard setting methods in medical education / Andr F. De Champlain -- Formative assessment / Diana F Wood -- Thinking about research: theoretical perspectives, ethics and scholarship / Jan Illing -- Quantitative research methods in medical education / Geoff Norman and Kevin W Eva -- Qualitative research in medical education: methodologies and methods / Lorelei Lingard, Tara J. Kennedy and Stella Ng -- Programme evaluation: improving practice, influencing policy and decision-making / Chris Lovato and David Wall -- Selection into medical education and training / Fiona Patterson , Eammon Ferguson and Alec Knight -- Career progression and support / Caroline Elton and Nicole J. Borges -- Managing remediation / Deborah Cohen, Melody Rhydderch and Ian Cooper -- Dealing with diversity / Anthony Americano and Dinesh Bhugra -- Developing medical educators: a journey, not a destination / Yvonne Steinart -- Educational leadership / Judy McKimm and Tim Swanwick.
- 2010 ebrarySwanwick, Tim.Understanding Medical Education originated as a series of monographs in September 2006, the brainchild of Association of Medical Education's then Chief Executive, Frank Smith. The series was designed to meet the needs of all newcomers to medical education. Contributors have included experts from all walks of medical education from across the world. These monographs which have now been collected into a single core textbook, provide a comprehensive guide to the theoretical and academic bases to modern medical education practice--from notes provided by publisher.
- 2014 AccessMedicineLevinson, Wendy; Ginsburg, Shiphra; Hafferty, Frederic W.; Lucey, Catherine R.A practical approach to 'professionalism' -- Building professional resiliency -- A brief history of medicine's modern-day professionalism movement -- Professional behaviors and skills needed to deliver patient-centered care -- Integrity and accountability -- Professionalism and a commitment to excellence -- Fair and ethical stewardship of health care resources -- The 'hidden curriculum' and professionalism -- Education -- Evaluating professionalism -- When things go wrong -- Organizational professionalism.
- Understanding military workforce productivity : effects of substance abuse, health, and mental health2014 SpringerBray, Robert M.From the stresses of repeated deployments to the difficulties of re-entry into civilian life, we are just beginning to understand how protracted conflicts, such as those in Iraq and Afghanistan, are affecting service members. Issues such as risky health behaviors and chemical dependence raise productivity concerns as they do with all organizations, but they also have a profound impact on the safety and readiness of troops--and by extension, the military as a whole--in life-or-death situations. Understanding Military Workforce Productivity cuts through the myths and misconceptions about the health and resilience of today's active-duty armed forces. This first-of-its-kind volume presents up-to-date findings across service branches in core health areas including illness and injury, alcohol and drug abuse, tobacco use, obesity, and mental health. The short- and long-term implications discussed relate to the quality of the lives of service members and their families, the quality and preparedness of the military as a workforce, and prevention and intervention efforts.
- 2007 ProQuest SafariPachev, Alexander Sasha.
- 2005 CRCnetBASEGriffiths, Mansel.
- 2012 AccessMedicineWachter, Robert M.An introduction to patient safety and medical errors -- The nature and frequency of medical errors and adverse events -- Basic principles of patient safety -- Safety, quality, and value -- Medication errors -- Surgical errors -- Diagnostic errors -- Human factors and errors at the person-machine interface -- Transition and handoff errors -- Teamwork and communication errors -- Healthcare-associated infections -- Other complications of healthcare -- Patient safety in the ambulatory setting -- Information technology -- Reporting systems, root cause analysis, and other methods of understanding safety issues -- Creating a culture of safety -- Workforce issues -- Education and training issues -- The malpractice system -- Accountability -- Accreditation and regulations -- The role of patients -- Organizing a safety program.
- 2014 AccessMedicineMosser, Gordon; Begun, James W.A complete introductory guide to the principles and clinical application of team-based medicine, Understanding Team-Based Healthcare emphasizes the essential competencies necessary to implement team-based medicine in a complex hospital or primary care setting. Unlike similar books on the subject which are theoretical or policy-oriented, this text offers practical, real-world coverage, and is valuable for healthcare professionals seeking a thorough explanation of teamwork and for trainers working in hospitals or primary care settings. Features: could also be used as a textbook; mini-cases throughout the text help readers appreciate real-world application of principles; written for a level suited for the non-specialist.
- Understanding the interaction between graft placement, gait mechanics, and cartilage morphology as a pathway to osteoarthritis in the ACL reconstructed knee2010Scanlan, Sean Frederick; Andriacchi, Thomas P.; Delp, Scott; Safran, Marc R.The overall goal of this dissertation was to address the question of the relationship between anterior cruciate ligament (ACL) graft function, changes in walking mechanics, and the morphology of the articular cartilage in the ACL reconstructed knee as a step towards filling critical gaps in the available knowledge of the association between ACL injury and premature osteoarthritis of the knee. ACL injury often leads to premature osteoarthritis of the knee even when the ACL is reconstructed and alterations in knee mechanics during walking have been identified as a potential mechanism of cartilage degeneration in the ACL deficient knee. This thesis provides the results of experimental studies using magnetic resonance (MR) imaging and gait analysis to understand the effect of ACL reconstruction on the mechanics of walking and articular cartilage morphology in the context of a potential mechanism for the initiation of osteoarthritis. These results provide a basis for improving the treatment and long-term prognosis of the ACL injured knee. Gait analysis of subjects after ACL reconstruction showed that during the stance phase of walking, their ACL reconstructed knee had significantly more external tibial rotation when compared to their contralateral knee. This kinematic alteration likely causes changes in normal cartilage contact mechanics and could contribute to the eventual degeneration of the articular cartilage. Analysis of ACL graft placement in this population revealed a potential mechanism for the observed alteration in ambulatory mechanics in the ACL reconstructed knee. Variations in graft placement were correlated with the magnitude of the peak external knee flexion moment (balanced by a net quadriceps moment) and the tibiofemoral rotational position of the reconstructed knee during walking. In both cases, non-anatomic graft placement resulted in greater deviations in the ambulatory mechanics of the ACL reconstructed knee. Since these results indicated graft placement plays a critical role in the restoration of normal ambulatory mechanics, MR imaging was utilized to develop a method to determine the three-dimensional location of native tibial and femoral ACL insertions to guide and evaluate anatomic ACL graft placement. Analysis of healthy and ACL reconstructed subjects revealed the presence of side-to-side symmetry in location of ACL insertions in healthy subjects but not after transtibial ACL reconstruction, indicating that conventional transtibial reconstruction frequently places the graft outside the center of the anatomical ACL footprint. Further examination of the effects of non-anatomic ACL graft placement revealed the unintended consequences of vertical sagittal orientation of the ACL graft. These results demonstrated that although vertical sagittal graft orientation was associated with less occurrence of an active knee extension deficit during walking (as intended), it was also associated with an increased anterior tibial neutral position in the ACL reconstructed knees. Finally, in order to investigate the mechanism of the proposed kinematic pathway to osteoarthritis after ACL reconstruction, the individual-specific femoral cartilage thickness distribution was related to knee flexion during walking in the reconstructed and healthy contralateral knees. The results of this study showed that although a relationship existed in both the reconstructed and contralateral knees, a shift in knee flexion at heel-strike without an adaptation in cartilage thickness distribution caused an alteration in the relationship in the ACL reconstructed knees. Thus failure of the ACL reconstruction to restore normal walking mechanics could contribute the breakdown of articular cartilage in the ACL reconstructed knee. The results of these studies provide a better understanding of the influence of ACL reconstruction on the subsequent changes in the mechanics of the ACL reconstructed knee. These findings present insights into the complex relationship between variations in ACL graft placement, changes in walking mechanics, and the distribution of cartilage thickness in the context of a potential kinematic mechanism for the development of premature osteoarthritis after ACL injury and reconstruction. Taken together, these results provide a basis for improving the standard of care for the ACL injured knee.
- Understanding the mechanis of mammalian damage tolerance proteins in suppressing damage-specific mutagenesis2012Lin, Jia-Ren; Cimprich, Karlene; Kopito, Ron; Meyer, Tobias; Wandless, Thomas.Post-replication repair (PRR) pathways play important roles in restarting stalled replication forks and regulating mutagenesis. In yeast, Rad5-mediated damage avoidance and Rad18-mediated translesion synthesis (TLS) are two forms of PRR. Two Rad5-related proteins, SHPRH and HLTF, have been identified in mammalian cells, but their specific roles in PRR are unclear. Here, we show that HLTF and SHPRH suppress mutagenesis in a damage-specific manner, preventing mutations induced by UV and MMS, respectively. Following UV, HLTF enhances PCNA monoubiquitination and recruitment of TLS polymerase eta, while also inhibiting SHPRH function. In contrast, MMS promotes the degradation of HLTF and the interactions of SHPRH with Rad18 and polymerase kappa. Our data not only suggest that cells differentially utilize HLTF and SHPRH for different forms of DNA damage, but also, surprisingly, that HLTF and SHPRH may coordinate the two main branches of PRR to choose the proper bypass mechanism for minimizing mutagenesis. Though the degradation of HLTF is required for the SHPRH-Rad18 interaction in MMS-damaged cells, knockdown of HLTF is not sufficient to induce SHPRH-Rad18 binding in undamaged cells. Thus, an unidentified factor, in addition to HLTF degradation, is required to fully activate SHPRH and Rad18 upon MMS damage. We have noticed that Rad18 is deubiquitinated after MMS treatment, and that this de-ubiquitination is correlated with the degree of Rad18-SHPRH interaction. Moreover, we show that promoting the ubiquitination of Rad18 has an inverse effect on the interaction with SHPRH both in vitro and in cells. Surprisingly, though, the ubiquitinated Rad18 shows a stronger self-interaction than the wild-type Rad18, opposite from the SHPRH binding results. As the zinc-finger motif of Rad18 has been previously shown to bind ubiquitin, this may be a logical mechanism to control the switch between Rad18 dimerization and its interaction with other proteins. Interestingly, ubiquitinated Rad18 appears to be inactive, not only from loss of its ability to interact with SHPRH, but also through the inability to form damage foci and suppress MMS-induced mutagenesis. Altogether, our data reveal a unique regulation of Rad18 through self-ubiquitination and dimerization. In summary, our studies have revealed a number of new mechanistic insights into the post-replication repair pathways in human cells, including the interesting conclusion that protein degradation, deubiquitination, and other key cell processes may be controlled in a DNA damage-specific manner.
- 2013Sommese, Ruth; Krasnow, Mark; Spudich, James A.; Straight, Aaron.Heart disease is one of the leading causes of morbidity and mortality in the developed world. As such, significant amount of resources and energy are funneled into developing treatments and therapeutics. While genetically caused cardiovascular diseases manifest at the tissue level, the fundamental mechanism that triggers the secondary effects and tissue remodeling generally occurs at the protein level. It is therefore critical to understand the molecular changes on the basic biochemical and biophysical level and connect these to the cellular and developmental disease processes. One such cardiovascular disorder is hypertrophic cardiomyopathy or HCM, which has been estimated to affect approximately 1 in 500 individuals. It disproportionately affects young adults and is the leading cause of sudden cardiac death. Since the first case of genetically linked HCM was identified in the early 1990s, a significant amount of work has been done to understand the molecular mechanism of the disease. Mutations have been identified in the proteins comprising the contractile apparatus of the muscle, the sarcomere. One such protein is [beta]-cardiac myosin, which has been recognized as a significant culprit of genetically linked HCM (~30-50%). Many studies have been performed to understand how single point mutations can alter the enzymatic and mechanical properties of this motor protein, but there is no clear consensus about the molecular mechanism. This has been due mainly to the lack of available human [beta]-cardiac myosin and the use of non-human and non-[beta]-cardiac myosin. Non-human and non-[beta]-cardiac myosin from common animal models differ by >30 residues, and as clearly evident from the disease and from previous studies on myosin, a single amino acids mutation can significantly alter and disrupt myosin function. During my thesis work, I have performed the first biochemical and biophysical work in the field looking at cardiomyopathy mutations using human [beta]-cardiac myosin. I have shown that HCM-causing [beta]-cardiac myosin mutations result in a gain of function, increasing the power or work output of the myosin. I have also examined HCM-causing mutations in troponin T, a component of the thin filament regulatory unit, using human [beta]-cardiac myosin. In the muscle, the interaction of myosin and actin is regulated by calcium through the thin filament proteins, namely the troponin complex and tropomyosin. HCM-causing mutations in troponin T increase calcium sensitivity or the number of force-producing heads that can interact with actin, thereby also increasing force or power output in the muscle. My work not only sheds light on fundamental properties of thick and thin filament function in the human sarcomere and presents the first studies of HCM-causing mutants in a human background, it also establishes a new approach to the problem of cardiomyopathy that will be critical in truly understanding and targeting the disease.
- Ubiquitin and protein degradation. Part A-B — Understanding the molecular mechanisms of cardiomyopathy-causing mutations in sarcomeric proteins (100)
- Understanding the role of lipids in tear-film stability — Using integrative genomic approaches to understand the biology of pancreatic cancer (100)
- Using mass spectrometry for drug metabolism studies. 2nd ed. — Uveitis-- fundamentals and clinical practice. 4th ed. (31)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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