- Ubiquitin and protein degradation. Part A-B — Understanding medical education : evidence, theory, and practice. Second edition. [2nd ed.] (100)
- Understanding medical education : evidence, theory and practice. 1st ed. — U.S. decennial life tables for 1989-91. Volume II, State life tables (100)
- U.S. health in international perspective : shorter lives, poorer health — Uveitis-- fundamentals and clinical practice. 4th ed. (50)
- pt. A-B, 2005. ScienceDirectpt. B ScienceDirectedited by Raymond J. Deshaies.Also available: Print – pt. A-B, 2005.
- 2012 Springer Protocolsedited by R. Jürgen Dohmen, Martin Scheffner.
- 2009/2010Ivette Shiba Estay.
- 2009 Springervolume editor, Stefan Jentsch, Bernhard Haendler.
- 2005 Springer Protocolsedited by Cam Patterson, Douglas M. Cyr.Assays of proteasome-dependent cleavage products / Stefan Tenzer and Hansjörg Schild -- Identification of components of protein complexes / Carol E. Parker ... [et al.] -- Mass spectroscometric determination of protein ubiqitination / Carol E. Parker ... [et al.] -- Reconstitution of endoplasmic reticulum-associated degradation using yeast membranes and cytosol / Robert J. Lee, Ardythe A. McCracken, and Jeffrey L. Brodsky -- Reticulocyte lysate as a model system to study endoplasmic reticulum membrane protein degradation / Eric Carlson ... [et al.] -- Deubiquitinating enzyme purifucation, assay inhibitors and characterization / Nathaniel S. Russell and Keith D. Wilkinson -- Measuring ubiquitin conjugation in cells / Edward G. Mimnaugh and Leonard M. Neckers -- Assays for proteasome assembly and maturation / R. Jürgen Dohmen ... [et al.] -- N-terminal ubiquitination / Aaron Ciechanover -- Quantitating defective ribosome products / Shu-Bing Qian, Jack R. Bennink, and Jonathan W. Yewdell -- Endoplasmic reticulum-associated protein quality control and degradation: screen for ERAD mutants after ethylmethane sulfonate mutagenesis / Antje Schäfer and Dieter H. Wolf -- Endoplasmic reticulum-associated protein quality control and degradation: genome wide screen for ERAD components / Antje Schäfer and Dieter H. Wolf -- Cystic fibrosis transmembrane conducatance regulator as a model substrate to study endoplasmic reticulum protein quality control in mammalian cells / J. Michael Younger ... [et al.] -- Aggresome formation / Michael J. Corboy, Philip J. Thomas, and W. Christian Wigley -- Detection of sumoylated proteins / Roland S. Hilgarth and Kevin D. Sarge -- Proteasome inhibitors in cancer therapy / Robert Z. Orlowski -- Parkinson disease: assays for the ubiquitin ligase activity of neural parkin / Michael G. Schlossmacher and Hideki Shimura. Small-molecule inhibitors of proteasome activity / Maria Gaczynska and Pawel A. Osmulski -- Purification of E1 and E1-like enzymes / Arthur L. Haas -- Assays for RING family ubiquitin ligases / Manabu Furukawa, Paul S. Andrews, and Yue Xiong -- Ubiquitin chain synthesis / Shahri Raasi and Cecile M. Pickart -- Purification of proteasomes, proteasome subcomplexes, and proteasome-associated proteins from budding yeast / David S. Leggett, Michael H. Glickman, and Daniel Finley -- Recognition and processing of misfolded proteins by PA700, the 19S regulatory complex of the 26S proteasome / Chang-Wei Liu ... [et al.] -- Cell-free assay for ubiquitin-independent proteasomal protein degradation / Chaim Kahana and Yuval Reiss --
- Hasman, Arie.
- UHMWPE biomaterials handbook : ultra high molecular weight polyethylene in total joint replacement and medical devices. 2nd ed.2009 ScienceDirect2009 Knoveleditor, Steven M. Kurtz.A primer on UHMWPE / Steven M. Kurtz -- From ethylene gas to UHMWPE component : the process of producing orthopedic implants / Steven M. Kurtz -- Packaging and sterilization of UHMWPE / Steven M. Kurtz -- The origins of UHMWPE in total hip arthroplasty / Steven M. Kurtz -- The clinical performance of UHMWPE hip replacements / Steven M. Kurtz -- Contemporary total hip arthoplasty : hard-on-hard bearings and highly crosslinked UHMWPE / Steven M. Kurtz, Kevin Ong -- The origins and adaptations of UHMWPE for knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in knee replacements / Steven M. Kurtz -- The clinical performance of UHMWPE in shoulder replacements / Stefan M. Gabriel -- The clinical performance of UHMWPE in elbow replacements / Judd S. Day -- Applications of UHMWPE in total ankle replacements / Allyson Ianuzzi, Chimba Mkandawire -- The clinical performance of UHMWPE in the spine / Steven M. Kurtz, Marta L. Villarraga, Allyson Ianuzzi -- Highly crosslinked and melted UHMWPE / Orhun K. Muratoglu -- Highly crosslinked and annealed UHMWPE / John H. Dumbleton, Aiguo Wang, Kate Sutton ...[et al.] -- Highly crosslinked UHMWPE doped with vitamin E / Ebru Oral, Orhun K. Muratoglu -- Vitamin-E-blended UHMWPE biomaterials / Steven M. Kurtz, Pierangiola Bracco, Luigi Costa -- Composite UHMWPE biomaterials and fibers / Steven M. Kurtz -- UHMWPE / hyluronan microcomposite biomaterials / Susan P. James, Rachel (Kurkowski) Oldinski, Min Zhang ...[et al.] -- High pressure crystallized UHMWPEs / Anuj Bellare, Steven M. Kurtz -- Compendium of highly crosslinked UHMWPEs / Steven M. Kurtz -- Mechanisms of crosslinking, oxidative degradation and stabilization of UHMWPE / Luigi Costa, Pierangiola Bracco -- In vivo of UHMWPE / Steven M. Kurtz -- Pathophysiologic reactions to UHMWPE wear particles / Marla J. Steinbeck, Ryan M. Baxter, Theresa A. Freeman -- Characterization of physical, chemical, and mechanical properties of UHMWPE / Stephen Spielgelberg -- Tribological assessment of UHMWPE in the hip / Aaron Essner MS, Aiguo Wang -- Tribological assessment of UHMWPE in the knee / Hani Haider -- Characterization of UHMWPE wear particles / Tipper JL., Richards L., Ingham E. ...[et al.] -- Clinical surveillance of UHMWPE using radiographic methods / Charles R. Bragdon -- ESR insights into macroradicals in UHMWPE / M. Shah Jahan -- Fatigue and fracture of UHMWPE / Francisco J. Medel, Jevan Furmanski -- Development and application of the notched tensile test to UHMWPE / Michael C. Sobieraj, Clare M. Rimnac -- Development and application of the small punch test to UHMWPE / Avram A. Edidin -- Nano- and microindentation testing of UHMWPE / Jeremy L. Gilbert, James D. Wernle -- MicroCT analysis of wear and damage in UHMWPE / Daniel MacDonald, Anton Bowden, Steven M. Kurtz -- Computer modeling and simulation of UHMWPE / Anton E. Bowden, Erin Oneida, Jorgen Bergström.
- 2005- WileyUllmann, Fritz.Covers science and technology in all areas of industrial chemistry, containing nearly 1000 major articles with more than 16 million words, nearly 10,000 tables, 30,000 figures, and literature sources and cross-references. It also includes full text index, author index, CAS registry number index, and keyword index.
- 2007[edited by] Brian Freeman.
- 2013 AccessMedicine[edited by] Brian S. Freeman.Online 3rd edition inlcudes only selected chapters as of 1/10/2014.
- Koushik Shaw.
- 2006 SpringerPierre-Marie Robitaille, Lawrence Berliner [eds.].
- Ultra-high molar mass linear polyacrylamide (LPA) networks for microchannel electrophoresis : tuning LPA matrix dynamics and rheological responses to optimally impact DNA migration mechanism2012Thomas Patrick Niedringhaus.Since the 2003 completion of the human genome by means of the Sanger-based DNA sequencing strategy and capillary array electrophoresis, the scientific and medical community has worked to make personalized medicine a reality. Next-generation DNA sequencing technologies with astoundingly high throughput are now in use and have provided exciting new capabilities. However, next-generation instruments are currently incapable of providing highly accurate, long sequencing read lengths, have difficulty sequencing through repetitive sequences, and have yet to "scale down" well for point-of-care diagnostics. The 600 to 700 base read lengths at 98% accuracy that are provided by capillary electrophoresis and the Sanger method are still the gold standard for medical sequencing. In recent years, there has been a natural progression from CAE to microchip electrophoresis. Microchip electrophoresis provides highly accurate sequencing at a small compromise to read length (~ 500 to 600 bases) while offering the potential for a significant increase in throughput due to the reduced separation times and the possibility to create a lab-on-a-chip (LOC) device that integrates upstream sample preparation steps. These advantages render CAE and microchip electrophoresis platforms desirable for clinical diagnostic tests since they offer highly accurate sequencing needed to analyze medically relevant genes and precisely genotype forensic samples. Therefore, this work focuses on understanding variables that influence the migration mechanism of single-stranded DNA (ssDNA) through physically- entangled polymer matrices used in CAE and microchip electrophoresis in an effort to increase throughput and bridge the gap for clinical adoption. First, I discuss the application of the biased reptation model (BRM) to CAE sequencing separations. In this study, I report the synthesis and characterization of an ultra-high molar mass linear polyacrylamide (LPA) to be used as a replaceable, physically-entangled polymer matrix and the migration mechanisms of ssDNA through the LPA matrices are evaluated using reptation plots. Properties of the LPA matrices (i.e. average pore size and viscosity) is tuned by the overall polymer concentration as well as mixing ultra-high and low molar mass LPA. In the end, a blended LPA solution generates a dynamically responsive polymer matrix that increases sequencing read lengths by delaying the onset of oriented biased reptation. The near-optimal blended LPA matrix which extends average read lengths to 830 bases in ~1 hour on a high-throughput CAE instrument. This represents a performance that is substantially better than the best commercial instrument/matrix CAE system available, which takes 2 hours to produce 830 bases. This was achieved by matrix optimization only. Second, I discuss transient effects on the DNA sequencing read length caused by shear-induced LPA stretching during the pressure-induced capillary loading of the polymer matrix which results in entanglement inhomogeneity. The network inhomogeneity, in turn, increases peak widths due to mobility variation among ssDNA fragments in the radial direction of the microchannel. The contributions of the matrix rheological properties, microchannel dimensions, and loading pressure to the shear forces placed on the matrix during loading are thoroughly examined. Finally, tests were carried out on microfluidic chips to reduced polymer network disruption. In the end, the loading conditions were optimized to enable loading and unloading of a sequencing matrix in less than 1 minute that also provides sequencing read lengths on the order of 550 to 600 bases in ~ 8 minutes. These results provide universal parameters for high-throughput loading of polymer matrices into capillaries and microchips used in electrophoretic genotyping assays and newly invented LOC platforms, such that the performance of the matrix will be optimal.
- 2008Simone Sigrid Marticke.
- 2008 SpringerMarkus Braun, Peter Gilch, Wolfgang Zinth (eds.).Ultrahigh-resolution optical coherence tomography using femtosecond lasers / J. G. Fujimoto ... [et al.] -- Two-photon laser scanning microscopy / A. Nimmerjahn, P. Theer, F. Helmchen -- Femtosecond lasers in ophthalmology: surgery and imaging / J. F. Bille -- Ultrafast peptide and protein dynamics by vibrational spectroscopy / P. Hamm -- Photosynthetic light-harvesting / T. Pullerits, T. Polivka, V. Sundström -- Primary photosynthetic energy conversion in bacterial reaction centers / W. Zinth, J. Wachtveitl -- Ultrafast primary reactions in the photosystems of oxygen-evolving organisms / A. R. Holzwarth -- Primary photochemistry in the photoactive yellow protein: the prototype xanthopsin / D. S. Larsen, R. van Grondelle, K. J. Hellingwerf -- Structure based kinetics by time-resolved X-ray crystallography / M. Schmidt -- Primary reactions in retinal proteins / R. Diller -- Ultrashort laser pulses in single molecule spectroscopy / E. Houstein, P. Schwille.
- 2015 Cambridgeedited by Botros R.M.B. Rizk, MD, FRCOG, FACOG, HCLD, FACS, FRCS(C), Professor of Obstetrics and Gynecology and Director of the Division of Reproductive Endocrinology and Infertility, University of South Alabama College of Medicine, Mobile, AL, USA, President Elect, Middle East Fertility Society, Elizabeth E. Puscheck, MD, MS, FACOG, Professor and Chair of the Department of Obstetrics and Gynecology, Director of Gynecologic Ultrasound, Wayne State University Medical School, Detroit, MI, USA.Section 1. Techniques -- Section 2. Benign gynecology -- Section 3. Ectopic pregnancy -- Section 4. Gynecologic neoplasia -- Section 5. Ultrasonography in infertility.
- 2008 ClinicalKey[edited by] Peter W. Callen.Also available: Print – 2008
- 2015 SpringerPaula Ferrada, editor.I. Basics of Ultrasound -- 1. The Machine -- 2. Frequency and probes -- 3. Common Artifacts -- 4. The Doppler Effect -- II. Thoracic Ultrasound -- 5. The Pleura -- 6. The Lung -- 7. Procedures -- 8. Cases -- III. Echocardiogram for the Intensivist -- 9. Rationale -- 10. Limited echocardiogram vs. full service echo -- 11. The Windows -- 12. The Measurements -- 13. The interpretation -- 14. Cases -- IV. Vascular Ultrasound in the Critically Ill -- 15. Deep Venous Thrombosis -- 16. Line Placement -- 17. Cases -- V. Basic Abdominal Ultrasound in the ICU -- 18. Evaluation for free fluid -- 19. Basic Renal ultrasound -- 20. Evaluation of the Gallbladder -- 21. Procedures -- 22. Cases -- VI. Soft Tissue -- 23. Facial Dehiscence -- 24. Soft tissue masses and collections -- VII. Other Issues -- 25. Training Challenges -- 26. Credentialing Process -- 27. Billing and Coding.
- 2011 SpringerWilhelm Schäberle.Fundamental principles -- Peripheral arteries -- Peripheral veins -- Shunts -- Extracranial cerebral arteries -- Visceral and retroperitoneal vessels -- Penile and scrotal vessels.
- 2012 SpringerMirko D'Onofrio [editor] ; foreword by Claudio Bassi, Paolo Pederzoli.Ultrasound Imaging / Anna Gallotti and Fabrizio Calliada -- Transabdominal Ultrasonography of the Pancreas / Elisabetta Buscarini and Salvatore Greco -- Endoscopic Ultrasonography of the Pancreas / Elisabetta Buscarini and Stefania De Lisi -- Percutaneous Ultrasound Guided Interventional Procedures in Pancreatic Diseases / Elisabetta Buscarini and Guido Manfredi -- Intraoperative Ultrasonography of the Pancreas / Mirko D'Onofrio, Emilio Barbi, Riccardo De Robertis, Francesco Principe and Anna Gallotti, et al. -- Pancreatic Anatomy, Variants and Pseudolesions of the Pancreas / Emilio Barbi, Salvatore Sgroi, Paolo Tinazzi, Stefano Canestrini and Anna Gallotti, et al. -- Pancreatitis and Pseudocysts / Steffen Rickes and Holger Neye -- Solid Pancreatic Tumors / Christoph F. Dietrich, Michael Hocke, Anna Gallotti and Mirko D'Onofrio -- Cystic Pancreatic Tumors / Mirko D'Onofrio, Paolo Giorgio Arcidiacono and Massimo Falconi -- Rare Pancreatic Tumors / Roberto Malagò, Ugolino Alfonsi, Camilla Barbiani, Andrea Pezzato and Roberto Pozzi Mucelli -- Imaging Correlation / Marie-Pierre Vullierme and Enrico Martone -- Pancreatic Lesions: Pathologic Correlations / Paola Capelli and Alice Parisi -- Clinical and Imaging Scenarios / Anna Gallotti and Riccardo Manfredi -- Flowcharts in Pancreatic Diseases / Elisabetta Buscarini.
- 2014 SpringerFerdinando Draghi.This practice-oriented book, containing a wealth of high-quality ultrasound images, provides clear, concise, and complete coverage of the normal anatomy of the hand and wrist - tendons, nerves, and vascular structures - as well as the main pathologic conditions encountered in this area. The ultrasound images have been acquired with state of the art scanners and carefully labeled to facilitate recognition of each and every anatomic structure. Helpful comparison is also made with images and findings obtained using other diagnostic techniques, including in particular magnetic resonance imaging. The lucid text is complemented by practical tables summarizing key points for ease of reference. Readers will find Ultrasonography of the Upper Extremity to be a rich source of information on anatomy, examination techniques, and ultrasound appearances of one of the anatomic regions to have benefited the most from the technological revolution that has taken place in the field of ultrasonography during recent years. The book will appeal to both novice and experienced practitioners, including above all radiologists and ultrasound technicians but also rheumatologists and orthopedic surgeons.
- 2015 SpringerEnzo Silvestri, Alessandro Muda, Davide Orlandi ; foreword by Nicola Maffulli.The book provides a comprehensive description of the basic ultrasound principles, normal anatomy of the lower limb muscles and classification of muscle strain injures. Ultrasound images are coupled with anatomical schemes explaining probe positioning and scanning technique for the various muscles of the thigh and leg. For each muscle, a brief explanation of normal anatomy is also provided, together with a list of tricks and tips and advice on how to perform the ultrasound scan in clinical practice. This book is an excellent practical teaching guide for beginners and a useful reference for more experienced sonographers.
- 2012 SpringerAndrew Nicolaides, Kirk W. Beach, Efthyvoulos Kyriacou, Constantinos S. Pattichis, editors.
- 2010 Springerby Vladimir P. Kharchenko, Peter M. Kotlyarov, Mikhail S. Mogutov, Yury K. Alexandrov, Alexander N. Sencha, Yury N. Patrunov, Denis V. Belyaev.As the basis for this book, the authors have analyzed more than 100,000 ultrasound examinations performed between 1995 and 2008 in patients with thyroid and parathyroid disease, as well as many thousands of diagnostic and therapeutic ultrasound-guided minimally invasive procedures. The opening chapters include discussion of current ultrasound techniques, pitfalls, and ultrasound examination of the thyroid in children. Detailed attention is then devoted to findings in the normal thyroid and in the presence of diffuse and focal changes.
- 2012 SpringerJoão Miguel Sanches, Andrew F. Laine, Jasjit S. Suri, editors.Ultrasound Imaging: Advances and Applications presents some of the recent advances in Ultrasound imaging technology covering several organs and techniques in a Biomedical Engineering (BME) perspective. The focus of the book is in the algorithms, methodologies and systems developed by multidisciplinary research teams of engineers and physicians for Computer-Aided Diagnosis (CAD) purposes. Cardiovascular and Cancer, the most common life-threatening diseases in western countries, are two of the most important topics focused in the book. However, other advanced issues are also presented such as Intravascular Ultrasound, 3D US and Ultrasound in Computer-Aided Surgery (CAS). Some chapters are direct contributions from medical research groups where Ultrasound has also received great attention in the last decade. By this, new techniques based on Ultrasound were introduced in the clinical practice for diagnosis and therapeutics, mainly in hospital facilities.
- 2016 Kargervolume editors Mario Meola, Ilaria Petrucci, Claudio Ronco.Pathophysiology and clinical work-up of acute kidney injury / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Ultrasound in acute kidney disease / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : pre-renal acute kidney injury / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : hepato-renal syndrome / Meola, M., Nalesso, F., Petrucci, I., Samoni, S., Ronco, C -- Clinical scenarios in acute kidney injury : parenchymal acute kidney injury tubulo-interstitial diseases / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Clinical scenarios in acute kidney injury-parenchymal acute kidney injury, vascular diseases / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Clinical scenarios in acute kidney injury : post-renal acute kidney injury / Meola, M., Samoni, S., Petrucci, I., Ronco, C -- Imaging in chronic kidney disease / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : vascular chronic diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : parenchymal chronic renal diseases, part 1 / Petrucci, I., Samoni, S., Meola, M -- Clinial scenarios in chronic kidney disease : parenchymal chronic renal diseases, part 2 / Petrucci, I., Samoni, S., Meola, M -- Clinical scenarios in chronic kidney disease : chronic tubulointerstitial diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : cystic renal diseases / Meola, M., Samoni, S., Petrucci, I -- Clinical scenarios in chronic kidney disease : kidneys' structural changes in end stage renal disease / Meola, M., Samoni, S., Petrucci, I.
- 2014 SpringerLaurel A. Stadtmauer, Ilan Tur-Kaspa, editors.Part I: Ultrasound Technique -- Ultrasound in Reproductive Medicine: Is It Safe?- Principles of 3D Ultrasound -- Two Dimensional and Three Dimensional Doppler in Reproductive Medicine -- Legal Aspects of Ultrasound Imaging in Reproductive Medicine -- Part II: Ultrasound in Infertility Workup -- The Normal Ovary -- Ovarian Reserve and Ovarian Cysts -- Ultrasound and PCOS -- The Normal Uterus -- Congenital Uterine Anomalies -- Uterine Fibroids -- Endometrial Polyps -- Intrauterine Adhesions -- Sonohysterography (SHG) in Reproductive Medicine -- Evaluation of Tubal Patency (HyCoSy, Doppler) -- Hydrosalpinx -- Virtual Hysterosalpingography: A New Diagnostic Technique for the Study of the Female Reproductive Tract -- Ultrasound in Male Infertility -- Part III: Ultrasound in Infertility Treatment -- Ultrasound in Follicle Monitoring for Ovulation Induction/IUI -- 2D Ultrasound in Follicle Monitoring for ART -- 3D Ultrasound in Follicle Monitoring for ART -- Ultrasound Guided Surgical Procedures -- Ultrasound Role in Embryo Transfers -- Ultrasound and Ovarian Hyperstimulation Syndrome -- Pregnancy of Unknown Viability -- Ultrasound Evaluation of Ectopic Pregnancy -- Focused Ultrasound for Treatment of Fibroids.
- 2007Ilan E. Timor-Tritsch, Steven R. Goldstein.Ultrasound in gynecology: development and continuing evolution -- Applied physics: selecting and adjusting the equipment -- Instrumentation, modality selection, and documentation -- Conducting the gynecologic ultrasound examination -- Relevant pelvic anatomy -- Adenomyosis -- Congenital uterine anomalies -- Adnexal masses -- Menopausal dilemmas: how ultrasound has changed clinical management -- Lower urinary tract -- Early pregnancy -- Pregnancy failure -- Ectopic pregnancy -- Infertility -- Sonohysterography -- Ultrasound-guided procedures in gynecology -- Color doppler mapping in gynecology -- Transvaginal sonography and ovarian cancer -- Three-dimensional ultrasound in gynecology -- Ultrasound-enhanced bimanual examination -- Differential diagnosis of inflammatory diseases of the pelvis -- Pearls and pitfalls of transvaginal sonography.
- 2005 Thieme Book[edited by] Eberhard Merz ; contributors F. Bahlmann ... [et al.]; [translator, Terry Telger].v. 1: ObstetricsAlso available: Print – v. 1-, 2005-
- 2015 SpringerMatthew Jankowich, Eric Gartman, editors.Ultrasound in the Intensive Care Unit explores the current state of evidence supporting use of bedside ultrasound for procedural guidance and for the critical care-focused assessment of a variety of organ systems. This text covers standard practice areas, such as ultrasound guidance for vascular access in the ICU, as well as novel, less well-known applications such as the use of ultrasound for assessment of diaphragm function in patients with respiratory failure. As current ultrasound education is often dependent on widely varying local expertise, this book serves as a standard reference in what is at present a fragmented and challenging field of study for busy clinicians. By providing a comprehensive overview of the current state of critical care ultrasonography, with content contributed by experts in the field, this text will serve as a valuable resource that will allow education in critical care ultrasound to keep pace with the rapid technological growth that has driven this vital area of critical care medicine. Ultrasound in the Intensive Care Unit is essential reading for pulmonologists, practitioners in internal, hospitalist, and critical care medicine; educators and instructors in critical care ultrasound; and medical students, residents, and critical care trainees.
- 2013Randy L. King.Ultrasound-induced neurostimulation has recently gained increasing attention. Developments in the use of ultrasound to stimulate and modulate neural activity have raised the possibility of using ultrasound as a new investigative and therapeutic tool in brain research. Little is known about the mechanisms by which it affects neural activity or about the range of acoustic parameters and stimulation protocols that elicit responses. In this thesis, conditions are established for transcranial stimulation of the nervous system in vivo, using the mouse somatomotor response. It is reported that (1) continuous-wave stimuli are as effective as or more effective than pulsed stimuli in eliciting responses, and responses are elicited with stimulus onset rather than stimulus offset; (2) stimulation success increases as a function of both acoustic intensity and acoustic duration; (3) interactions of intensity and duration suggest that successful stimulation results from the integration of stimulus amplitude over a time interval of 50 to 150 ms; (4) the motor response elicited appears to be an all-or-nothing phenomenon, meaning stronger stimulus intensities and durations increase the probability of a motor response without affecting the duration or strength of the response; and (5) motor responses, measured by normalized EMG signals in the neck and tail regions, change signifcantly when sonicating rostral and caudal regions of the mouse motor cortex. Taken together our findings present good evidence for being able to target selective parts of the motor cortex with ultrasound neurostimulation in the mouse, steps that should provide encouragement for the development of new applications in larger animal models, including humans.
- 2008 ClinicalKeyBeryl R. Benacerraf.This book on prenatal diagnosis details the most common sonographically detectable fetal syndromes. It has an easy-to-follow approach of using lists and patterns of malformations to generate a differential diagnosis of the possible syndrome involved. The reader is then led to the more detailed description of each syndrome to determine the exact final diagnosis. The new edition incorporates 3D ultrasound throughout the book, as well as 20 syndromes not previously covered.
- 2007 SpringerG. Maconi, G. Bianchi Porro (eds.) ; with contributions by G. Bianchi Porro ... [et al.] ; foreword by A.L. Baert.
- 2014 SpringerGiovanni Maconi, Gabriele Bianchi Porro, editors.This is the second, updated and extended edition of a well-received book that offers a comprehensive overview of ultrasonographic imaging of acute and chronic gastrointestinal diseases, including acute abdomen, appendicitis, diverticulitis, inflammatory bowel diseases, neoplasms and masses, infections, malabsorption syndromes, and rare conditions. The value of ultrasound in each disorder is clearly explained and illustrated, and limitations identified. Information is also provided on recent technical developments and ultrasound applications that are likely to become of increasing importance, such as functional and 3D ultrasound, contrast agents and intraoperative ultrasound, elastography, and transperineal ultrasound. The authors are all distinguished experts in the topics they address. Ultrasound of the Gastrointestinal Tract will be a helpful guide in daily practice not only for radiologists but also for gastroenterologists, abdominal surgeons, pediatricians, and oncologists.
- 2015 SpringerBruce R. Gilbert, editor.History of Ultrasound -- Embryology Relevant to Ultrasound Imaging of the Male Genitalia -- Physical Principles of Ultrasound of the Male Genitalia -- Scrotal Ultrasound -- Penile Ultrasound -- Urology Ultrasound Practice Accreditation -- Genital Ultrasound Protocols: Putting it all Together!.
- 2007 SpringerStefano Bianchi, Carlo Martinoli [editors] ; with contributions by L.E. Derchi ... [et al.] ; foreword by A.L. Baert ; introduction by I.F. Abdelwahab.
- 2012 SpringerRobert A. Sofferman, Anil T. Ahuja, editors.Section I. History and Basic Concepts -- The History of Clinical Ultrasound -- Physics and Principles of Ultrasound -- Practical Concepts of Ultrasound -- Section II. Thyroid and Parathyroid Glands -- Sonography of the Normal Thyroid -- Benign Thyroid Conditions -- Malignant Thyroid Conditions -- Ultrasound Surveillance -- Parathyroid Ultrasound -- Fine Needle Aspiration Cytology -- Section III. Lymph Nodes and the Neck -- Lymph Nodes -- Benign Clinical Conditions in the Adjacent Neck -- Section IV. New Advances in Applied Ultrasound -- Thyroid Elastography -- Percutaneous Ethanol Injection for Thyroid and Parathyroid Disorders -- Contrast Enhanced Ultrasound and Ultrasound-Guided Minimally Invasive Therapy for the Diagnosis and Treatment of Focal Thyroid Lesions.
- 2006 Thieme Book[edited by] Grant M. Baxter, Paul S. Sidhu ; with contributions by P.L. Allan [and others].Nephrology -- Introduction: medical overview -- Normal kidney -- Parenchymal diseases of the kidney -- Chronic renal failure -- Renal transplantation -- Radiological intervention in the urogenital tract (including trauma and emergencies) -- Urology -- Urogenital tract: surgical overview -- Focal lesions of the kidney -- Diseases of the collecting system and ureters -- Diseases of the bladder and prostate -- Diseases of the testis and epididymis -- Diseases of the penis with functional evaluation -- Oncological management of tumors of the urogenital tract -- Urogenital tract in the child -- Ultrasound of the pediatric urogenital tract -- Other imaging modalities in the urogenital tract -- Non-ultrasound imaging of the urogenital tract -- New developments: ultrasound contrast agents -- Native kidney -- Transplant kidney.
- 2007 Thieme Book[edited by] Günter Schmidt ; with contributions by B. Beuscher-Willems ... [et al.] ; [translator, Terry Telger].Basic physical and technical principles -- The ultrasound examination -- Ultrasound documentation and reporting -- Function studies -- Interventional ultrasound -- Principal signs and symptoms -- Arteries and veins -- Cervical vessels -- Liver -- Kidney and adrenal gland -- Pancreas -- Spleen -- Bile ducts -- Gallbladder -- Gastrointestinal tract -- Urogenital tract -- Thorax -- Thyroid gland -- Major salivary glands -- Postoperative ultrasound -- Search for occult tumors.
- 2016 ClinicalKeyBarbara S. Hertzberg, William D. Middleton.This best-selling volume in The Requisites Series provides a comprehensive introduction to timely ultrasound concepts, ensuring quick access to all the essential tools for the effective practice of ultrasonography. Comprehensive yet concise, Ultrasound covers everything from basic principles to advanced state-of-the-art techniques. This title perfectly fulfills the career-long learning, maintenance of competence, reference, and review needs of residents, fellows, and practicing physicians. Covers the spectrum of ultrasound use for general, vascular, obstetric, and gynecologic imaging.
- 2014 SpringerGuido Torzilli, editor.Ultrasound guidance of liver surgery is a very sophisticated approach that permits the performance of otherwise unfeasible operations, discloses the true extent of tumors, increases the indications for hepatectomy, and renders surgery safer. Despite this, it has remained relatively neglected in the literature over the past two decades, during which time much progress has been achieved. This is the first atlas on the subject, and it is comprehensive in scope. The state of the art in the use of ultrasound for resection guidance is carefully documented, and new techniques for exploration of the biliary tract and facilitation of transplant surgery are presented. Further important topics include the role of ultrasound in laparoscopic approaches, the use of contrast agents for diagnosis and staging, and developments in the planning of surgical strategy. The editor is a leading authority whose group has been responsible for a variety of advances in the field. He has brought together other experts whose aim throughout is to provide clear information and guidance on the optimal use of ultrasound when performing liver surgery. This atlas is intended especially for hepatobiliary surgeons but will also be of considerable value for general surgeons.
- 2015 SpringerLuca Maria Sconfienza, Davide Orlandi, Enzo Silvestri, editors.
- 2012 SpringerLuca Maria Sconfienza, Giovanni Serafini, Enzo Silvestri, editors.pt. 1. General Aspects of US-guided Musculoskeletal Procedures -- General Aspects of US-guided Musculoskeletal Procedures / Armando Conchiglia, Lorenzo Maria Gregori, Luigi Zugaro and Carlo Masciocchi -- pt. I. The Shoulder -- The Shoulder: Focused US Anatomy and Examination Technique / Enzo Silvestri and Davide Orlandi -- Subacromial-Subdeltoid Bursa Injections / Enzo Silvestri -- Treament of Calcific Tendinitis of the Rotator Cuff / Giovanni Serafini and Luca Maria Sconfienza -- Calcific Enthesopathy Dry-Needling / Francesca Lacelli -- Hyaluronic Supplementation of the Subacromial Space / Giovanni Serafini -- Intra-articular Injections / Francesca Lacelli -- Long Head of the Biceps Brachii Tendon Injection / Luca Maria Sconfienza -- Acromioclavicular Joint Injection / Enzo Silvestri -- pt. II. The Elbow -- The Elbow: Focused US Anatomy and Examination Technique / Enzo Silvestri and Emanuele Fabbro -- Treatment of Lateral Epicondylitis / Giovanni Serafini -- Treatment of Medial Epicondylitis / Enzo Silvestri -- Olecranon Bursa Drainage / Francesca Lacelli -- Intra-articular Injections / Luca Maria Sconfienza -- pt. III. The Wrist -- The Wrist: Focused US Anatomy and Examination Technique / Enzo Silvestri and Giulio Ferrero -- Treament of De Quervain's Disease and Other Forms of Tenosynovitis / Giovanni Serafini -- Articular Ganglia Drainage / Leonardo Callegari -- Trapeziometacarpal Joint Injection / Francesca Lacelli -- Radiocarpal Joint Injections / Luca Maria Sconfienza -- pt. IV. The Hand -- The Hand: Focused US Anatomy and Examination Technique -- Francesca Lacelli and Chiara Martini -- Treatment of Trigger Finger / Leonardo Callegari -- Intra-articular Injections: Metacarpophalangeal and Interphalangeal Joints / Luca Maria Sconfienza.
- 2010 Thieme Bookedited by Vikram S. Dogra, Wael E.A. Saad.This handbook is a practical reference for the full range of common and complex ultrasound-guided procedures frequently performed in clinical practice. Divided into four sections, this book provides in-depth guidelines from renowned specialists for how to perform ultrasound-guided biopsies, how to utilize ultrasound to obtain access for interventional procedures and perform drainage, and how to perform ultrasound-guided percutaneous therapy and sonohysterography. Detailed coverage of such key procedures as thyroid biopsy, breast biopsy, sonohysterography, superficial lymph node biopsy, musculoskeletal interventions, and more. Concise bullet-point format that aids rapid reading and review of indications, contraindications, equipment, technique and post-procedural evaluation and possible complications and their management. More than 600 high-quality images and illustrations that clarify complex concepts.
- editors, Paul E. Bigeleisen, Michael Gofeld, and Steven L. Orebaugh ; associate editors, Nizar Moayeri, Annelot Krediet, Gerbrand J. Groen, Stephen Breneman, Bassem Asaad, and Jacques E. Chelly.
- 2015 Cambridgeedited by Stephen Mannion, Gabriella Iohom, Christophe Dadure, Mark Reisbig, Arjunan Ganesh.Performance of regional anesthesia in children / Arjunan Ganesh and Wallis T. Muhly -- Pharmacology of local anesthetics in children / Christina Van Horn and Mark D. Reisbig -- Management of complications / Immanuel Hennessy and Stephen Mannion -- Basics of ultrasonography for regional anesthesia in children / Christophe Dadure and Chrystelle Sola -- Anatomy of the neuraxis, thoracic, and abdominal walls, upper and lower limbs / Judith Barbaro-Brown and Gabriella Iohom -- Ultrasound guided axillary block in children / Pádraig O'Scanaill and Brian O'Donnell -- Ultrasound-guided supraclavicular brachial plexus block / Mark D. Reisbig -- Ultrasound guided infraclavicular brachial plexus block / Wallis T. Muhly and Arjunan Ganesh -- Ultrasound guided interscalene brachial plexus block / Harshad Gurnaney and Arjunan Ganesh -- Ultrasound guided femoral nerve block / Frédéric Duflo -- Ultrasound guided saphenous nerve block / Ahmed Abdel-Aziz and Amr Abdelaal -- Ultrasound guided sciatic nerve block / Anne-Charlotte Saour and Christophe Dadure -- Ultrasound guided ilioinguinal/iliohypogastric block / Sinead O'Shaughnessy and Charles Youngblood -- Transversus abdominis plane block / Eimhin Dunne and Brian O'Donnell -- Ultrasound guided rectus sheath block / Harshad Gurnaney and Arjunan Ganesh -- Ultrasound guided paravertebral block / Attila Bondár and Gabriella Iohom -- Ultrasound guided epidural anesthesia / Chrystelle Sola and Christophe Dadure -- Ultrasound for spinal anesthesia / Karthikeyan Kallidaikurichi Srinivasan and Peter Lee -- Ultrasound guided caudal block / Anca Grigoras and Jawad Mustafa -- Facial blocks / Chrystelle Sola and Christophe Dadure.
- 2005 KargerAnn M. Dvorak.Also available: Print – 2005
- 2016 SpringerGiuseppe Biondi-Zoccai, editor.1 Evidence hierarchy -- 2 From qualitative reviews to umbrella reviews -- 3 Umbrella reviews, overviews of reviews, meta-epidemiologic studies: similarities and differences -- 4 Designing the review -- 5 Registering the review -- 6 Searching evidence -- 7 Abstracting evidence -- 8 Appraising evidence -- 9 Synthesizing evidence -- 10 Appraising moderators and confounders -- 11 State of the art reporting -- 12 Case study in anesthesiology and intensive care -- 13 Case study in basic research -- 14 Case study in cardiovascular disease -- 15 Case study in dermatology -- 16 Case study in oncology -- 17 Case study in radiology -- 18 Case study in surgery -- 19 Moving from evidence to action -- 20 Avenues for further research -- 21 Conclusion.
- v. 2, 1953-.Neumann, Erich.-- v. 2. Zur Psychologie des Weiblichen.
- 2006 CRCnetBASEAnthony J. Rhem.
- 2013 ClinicalKey[edited by] Darcy Umphred [and others].Section I. Foundations for clinical practice in neurological rehabilitation. Foundations for clinical practice / Darcy A. Umphred, Rolando T. Lazaro and Margaret L. Roller -- Health and wellness: The beginning of the paradigm / Janet R. Bezner -- Movement analysis across the life span / Dale Scalise-Smith and Darcy A. Umphred -- Contemporary issues and theories of motor control, motor learning, and neuroplasticity / Margaret L. Roller ... [et.al.] -- The limbic system : Influence over motor control and learning / Darcy A. Umphred, Marcia Hall Thompson and Therese Marie West -- Psychosocial aspects of adaptation and adjustment during various phases of neurological disability / Rochelle McLaughlin and Gordon U. Burton -- Differential diagnosis phase 1 : Medical screening by the therapist / William G. Boissonnault and Darcy A. Umphred -- Differential diagnosis phase 2 : Examination and evaluation of functional movement activities, body functions and structures, and participation / Rolando T. Lazaro, Margaret L. Roller and Darcy A. Umphred -- Interventions for clients with movement limitations / Darcy A. Umphred ... [et.al.] -- Payment systems for services : Documentation through the care continuum / Barbara Edmison and John G. Wallace, Jr. -- Section II. Rehabilitation management of clients with neurological system pathology. Neonates and parents : Neurodevelopmental perspectives in the neonatal intensive care unit and follow-up / Jane K. Sweeney, Teresa Gutierrez and Joanna C. Beachy -- Management of clinical problems of children with cerebral palsy / Claudia R. Senesac -- Genetic disorders : A pediatric perspective / Sandra G. Bellamy and Eunice Yu Chiu Shen -- Learning disabilities and developmental coordination disorder / Stacey E. Szklut and Darbi Breath Philibert -- Spina bifida : A congenital spinal cord injury / Kristin J. Krosschell and Mari Jo Pesavento -- Traumatic spinal cord injury / Myrtice B. Atrice ... [et.al.] -- Neuromuscular diseases / Ann Hallum and Diane D. Allen -- Beyond the central nervous system : Neurovascular entrapment syndromes / Bradley W. Stockert, Laura J. Kenny and Peter I. Edgelow -- Multiple sclerosis / Gail L. Widener -- Basal ganglia disorders / Marsha E. Melnick -- Movement dysfunction associated with cerebellar damage / Susanne M. Morton and Amy J. Bastian -- Balance and vestibular dysfunction / Leslie K. Allison and Kenda Fuller -- Movement dysfunction associated with hemiplegia / Susan D. Ryerson -- Traumatic brain injury / Patricia A. Winkler -- Brain tumors / Corrie J. Stayner, Rachel M. Lopez and Karla M. Tuzzolino -- Inflammatory and infectious disorders of the brain / Judith A. Dewane -- Aging, dementia, and disorders of cognition / Osa Jackson Schulte, James Stephens and Joyce Ann -- Section III. Neurological disorders and applications issues. Disorders of vision and visual-perceptual dysfunction / Laurie Ruth Chaikin -- Pelvic floor treatment of incontinence and other urinary dysfunctions in men and women / Beate Carriere -- Cardiovascular and pulmonary system health in populations with neurological disorders / Marilyn Mackay-Lyons -- Human immunodeficiency virus infection : Living with a chronic illness / Kerri Sowers, Mary Lou Galantino and David M. Kietrys -- Pain management / Annie Burke-Doe -- Electrophysiological testing and electrical stimulation in neurological rehabilitation / Alain Claudel ... [et.al.] -- Orthotics : Evaluation, intervention, and prescription / Heidi Truman and Walter Racette -- Management of chronic impairments in individuals with nervous system conditions / Myla U. Quiben -- Impact of drug therapy on patients receiving neurological rehabilitation / Annie Burke-Doe and Timothy J. Smith -- Use of medical imaging in neurorehabilitation / Rolando T. Lazaro and Darcy A. Umphred -- Integrating technology into clinical practice in neurological rehabilitation / Katie Byl ... [et.al.] -- Complementary and alternative therapies : Beyond traditional approaches to intervention in neurological diseases and movement disorders / Darcy A. Umphred, Carol M. Davis and Mary Lou Galantino.
- Uncemented femoral stems for revision surgery : the press-fit concept - planning - surgical technique - evaluation2015 SpringerPierre Le Béguec, François Canovas, Olivier Roche, Mathias Goldschild, Julien Batard.Part I: Press-Fit Concept -- Uncemented Concepts: Parameters to Make a Choice -- The Press-Fit Concept: Principles and Press-Fittable Zones -- The Press-Fit Concept: Practical Application -- The Press-Fit Concept: Implants And Instruments -- Part II: Preoperative Planning -- Radiographic Analysis Of The Femur -- Selection of a Strategy -- Making a Preoperative Template -- Part III: Surgical Technique -- Trochantero-Diaphyseal Femoral Flap -- Femoral Flap and Diaphyseal Primary Fixation -- Endofemoral Approach and Proximal Primary Fixation -- Part IV: Evaluation of the Radiographic Results -- General Considerations -- A-Evaluation of the Radiographic Results ? How? -- Evaluation of Initial and Secondary Bone Stock -- Evaluation of Osseointegration and Secondary Stability -- Global Radiographic Score -- Comparative Elements with the Engh Score -- Part V: Evaluation of the Radiographic Results -- Why? -- The Learning Curve and its Teachings -- Different Types of Primary Stability: Their Impact on the Radiographic Results -- Degree of Osteoporosis: Its Impact on the Radiographic Results -- Affected Initial Bone Stock: Its Impact on the Radiographic Results -- Parameters to Improve Radiographic Results -- Complications and Contraindications -- Numerical Evaluation and Comparative Analysis of Results -- General Conclusions: What You Should and What You Should not Do.
- 2008 WHOPart 1: Guidance document on characterizing and communicating uncertainty in exposure assessment -- Part 2: Hallmarks of data quality in chemical exposure assessment.Also available: Print – 2008
- 2006 CRCnetBASEBilal M. Ayyub, George J. Klir.
- 2008edited by Louis R. Caplan ; founding editor, Julien Bogousslavsky.
- 2014 SpringerMarc Leone, Claude Martin, Jean-Louis Vincent, editors.This book highlights the practical characteristics of uncommon diseases and presents the most relevant features for the management of intensive care units. It does not aim to provide an exhaustive description of uncommon diseases, focusing instead on the major diseases that intensivists may encounter in their clinical practice. After a brief introduction on the epidemiology and pathophysiology of each disease, the authors emphasize the aspects related to diagnosis and treatment, providing concise and pragmatic guidance for residents and intensivists who care for patients with uncommon diseases. Although by definition uncommon diseases have a low prevalence in the general population, they can affect a large number of patients admitted to intensive care units, as they can often be diagnosed at intensive care units. Indeed, often a complication of the disease is what leads to the patient's being admitted to an intensive care unit.
- 2013 SpringerPaolo Pederzoli, Claudio Bassi, editors ; in collaboration with Massimo Falconi, Roberto Salvia and Giovanni Butturini ; foreword by Gianluigi Melotti.Cystic Pancreatic Neoplasms -- Classification / Giuseppe Zamboni -- Serous Cystic Neoplasms / Giuseppe Malleo, Giuseppe Zamboni, Marina Paini, Giovanni Marchegiani -- Mucinous Cystic Neoplasms / Giovanni Marchegiani, Riccardo Manfredi, Giuseppe Malleo, Isabella Frigerio -- Solid-pseudopapillary, Acinar, and Other Cystic Neoplasms / Marina Paini, Giuseppe Zamboni, Riccardo Manfredi, Salvatore Paiella, Giuseppe Malleo -- Intraductal Papillary Mucinous Neoplasms / Isabella Frigerio, Giuseppe Zamboni, Riccardo Manfredi, Antonio Pea, Silvia Pennacchio -- The Role of the Oncologist in the Diagnosis and Management of Malignant Cystic Neoplasms / Alessandra Auriemma, Davide Melisi, Giampaolo Tortora -- Neuroendocrine Pancreatic Neoplasms -- Epidemiology and Clinical Presentation / Maria Vittoria Davì, Marco Toaiari, Giuseppe Francia -- Pathology and Genetics / Aldo Scarpa, Vincenzo Corbo -- Imaging / Roberto Pozzi Mucelli, Giovanni Foti, Luigi Romano -- Surgical Therapy / Rossella Bettini, Stefano Partelli, Stefano Crippa, Letizia Boninsegna, Massimo Falconi -- Functional Imaging and Peptide Receptor Radionuclide Therapy / Maria Chiara Ambrosetti, Duccio Volterrani, Federica Guidoccio, Lisa Bodei -- Targeted and Other Non-receptor-mediated Therapies / Sara Cingarlini, Chiara Trentin, Elisabetta Grego, Giampaolo Tortora -- Uncommon Pancreatic Solid Neoplasms -- Rare Variants of Ductal Adenocarcinoma of the Pancreas / Paolo Regi, Marco Dal Molin, Federica Pedica, Paola Capelli, Mirko D'Onofrio -- Rare Primary Tumors of the Pancreas / Marco Dal Molin, Paola Capelli, Mirko D'Onofrio, Ivana Cataldo, Giovanni Marchegiani -- Rare Secondary Tumors of the Pancreas / Giovanni Butturini, Marco Inama, Marco Dal Molin, Mirko D'Onofrio, Davide Melisi -- Primary Non-epithelial Tumors of the Pancreas / Marco Dal Molin, Paola Capelli -- Tumor-like Lesions of the Pancreas / Luca Frulloni, Antonio Amodio, Italo Vantini, Marco Dal Molin, Marco Inama.
- 2012Jana Schaich Borg.Over half of all violent crimes are committed by only about 5% of offenders. While most healthy people feel strong aversion to seeing other people in pain, fear, or sadness, a phenomenon I define as "negative intersubjectivity", these persistent violent offenders (PVOs) have blunted reactions to other people's distress and the strength of their negative intersubjectivity deficit correlates with how much violence they ultimately perform. This suggests that if we could learn how to enhance PVOs aversion to other people's distress, we could decrease their violent behavior. In this dissertation, I describe a new rat model that can be used to study the neural mechanisms underlying negative intersubjectivity. I demonstrate that Observer rats will overcome their innate aversion of bright light to consistently avoid a dark, safe space if entering that dark space is paired with another Receiver rat getting shocked, a behavior called "intersubjective avoidance". In Chapter 2, I describe the relatively poor intersubjective avoidance behavior of mice. In Chapter 3, I describe the comparatively strong intersubjective avoidance behavior of rats, and show that rats' intersubjective avoidance is enhanced by personal experience with shock. In Chapter 4, I use patterns of expression of the immediate early gene c-Fos to determine whether activity in candidate brain regions correlates with intersubjective avoidance. I provide evidence that many brain regions--including the anterior cingulate, anterior insula, infralimbic cortex, and central amygdala--are active both when observing shock in another and when receiving shock to oneself, similar to what has been shown by fMRI studies of humans observing others in pain. However, within these areas, only activity in the anterior cingulate robustly correlates with how much intersubjective avoidance each individual Observer rat performs, perhaps analogous to how fMRI studies in humans have show that anterior cingulate activity correlates with humans' self-reports of "empathy". These results validate the rat model of intersubjective avoidance as model of negative intersubjectivity in humans, and highlight the anterior cingulate as a potential target for negative intersubjectivity interventions. In Chapter 5, I describe future experiments and discuss how research using this new behavioral paradigm may help develop treatments for not only PVOs, but all anti-social behavior.
- Under doctors' eyes : private life in Russian literature in the first half of the nineteenth century2012Ekaterina Neklyudova.My dissertation deals with the figure of the doctor in early Russian nineteenth-century prose, which manifests a shift in the way literature depicts human physicality and the characters' everyday life. My major source is 1820s-1840s prose, mostly published in the literary and cultural journals Biblioteka dlia Chtenia, Syn Otechestva, and others. My sources reflect the impressive expansion in Russian literature and medicine in the first quarter of the nineteenth century. Using documentary and literary sources, I demonstrate that the artistic representation of physicians in Romantic and Realist prose contributes to the introduction of previously unknown themes into literature: medical perspectives on physical suffering, the private everyday lives of ordinary people, and even the mystical view of other worlds. The combination of medical and mystical discourses in the vocabulary of real doctors in the first half of the nineteenth century gave them the authority to judge human bodies, lives, and, they believed, souls: they seemed to observe from inside and outside at the same time. By including a doctor among their characters, fiction writers thus could use a powerful instrument that let them introduce new topics. As I show, through the mid nineteenth century, the fictional doctors situated at the margin of literary plots performed the role of an important textual device: they served as go-betweens among other characters, mediating, connecting or splitting them. They affected the relationship between characters, the plot's trajectory, and the readers' perception. The situation shifts in mid century; with the gradual separation of doctor from his instrumental function, this character moves to the center of the plot and loses his structural power.
- 2016 SpringerMichael B. Chancellor, Ananias C. Diokno, editors.Epidemiology and Demographics of Underactive Bladder -- Evaluation and Diagnosis of Underactive Bladder.-Urodynamic Evaluation of Underactive Bladder -- Pathophysiology of UAB and Animal Modeling -- Nonsurgical Therapy; Catheters; Devices -- Current Drug Therapy for Underactive Bladder -- Novel Drugs for Underactive Bladder -- Neuromodulation Treatment of Underactive Bladder -- Surgery for Underactive Bladder Treatment -- Advance Technology -- Diabetes and Other Neurogenic Underactive Bladder -- Geriatric Urology and Underactive Bladder -- Pediatrics UAB -- Public Health and Advocacy for Underactive Bladder. Appendix 1: Guide to Underactive Bladder Care -- Appendix 2: Resources to Underactive Bladder Care.-.
- 2008 Springerby Thomas Bonk.
- 2012Charles Henry Brase, Corrinne Pellillo Brase.1. Getting Started -- 2. Organizing Data -- 3. Averages and Variation -- 4. Elementary Probability Theory -- 5. The Binomial Probability Distribution and Related Topics -- 6. Normal Curves and Sampling Distributions -- 7. Estimation -- 8. Hypothesis Testing -- 9. Correlation and Regression -- 10. Chi-Square and F Distributions -- 11. Nonparametric Statistics.
- Understanding and addressing food addiction : a science-based approach to policy, practice and research2016the National Center on Addiction and Substance Abuse at Columbia University.This white paper reviews and summarizes hundreds of scientific research papers by leading experts in the fields of addiction, eating disorders, obesity and nutrition to lay out the shared characterizing symptoms, risk factors and underlying neurobiological characteristics between food and substance addiction. It describes the differences between food addiction and binge eating disorder (now an official psychiatric diagnosis). It offers evidence-based recommendations for policy, prevention, health care practice and research, and offers informative resources for further examination of this emergent area of work. Finally, it highlights how the knowledge and experience gained from years of research, prevention and intervention work in tobacco, alcohol and other drug control might be applied to controlling another leading threat to the public health: unhealthy eating, overweight and obesity. The National Center on Addiction and Substance Abuse looks forward to contributing to this body of research and policy work through its new program at Yale under the direction of Dr. Carlos Grilo.
- 2015 SpringerMagdy El-Salhy, Jan Gunnar Hatlebakk, Trygve Hausken.1. Irritable bowel syndrome: what is it? -- 2. The digestive tract and how it works -- 3. The cause of irritable bowel syndrome -- 4. How is irritable bowel syndrome diagnosed? -- 5. Treatment options without medication -- 6. Treatment options involving medication -- 7. There is a light at the end of the tunnel.
- 2010Chad Michael Whitman.The mammalian cell surface is comprised of a heterogenous mixture of proteins and lipids decorated by carbohydrates. These molecules are known as glycoconjugates. Among the many types of glycolipids imbedded within the plasma membrane is a class of negatively charged species known as gangliosides. Gangliosides, which are characterized by the presence of sialic acid residues, are responsible for regulating the activity of many cell surface proteins and serve as recognition targets for cell-cell communication and pathogen invasion. To investigate the biological roles of gangliosides in mammalian cells, I have employed metabolic oligosaccharide engineering techniques to introduce small structural changes into sialic acid residues. Using these methods, I have successfully demonstrated the biosynthesis of photocrosslinking gangliosides in mammalian cells. These photocrosslinking gangliosides can be used to capture and isolate transient ganglioside-mediated interactions in their native environment. I have also used metabolic engineering techniques to probe the substrate selectivity of ganglioside sialyltransferases in mammalian cells. My results illustrate significant differences in the ability of different cell lines to metabolize sialic acid analogs; these differences may be due species-specific variations in sialyltransferase specificity.
- 2012Yen Ling Adelene Sim.RNA is an important biological macromolecule that carries out a variety of roles in the cell. To function, RNA needs to fold into precise three-dimensional structures. Different physical forces like entropy, base-pairing and stacking interactions, tertiary contacts and electrostatics affect this folding process. In the first part of this thesis, we focus on nucleic acid electrostatics; RNA molecules have negatively charged backbones that require counterions to neutralize charge-repulsion and facilitate folding. We discuss the ion conditions necessary for a riboswitch (gene-regulating RNA found on 5' or 3' ends of messenger RNA) folding, studied how the flexibility of single stranded DNA is affected by the presence of different amounts of counterions and present a benchmark experimental dataset that can be used for direct comparison to electrostatic theories. The second part of the thesis deals with computational and analysis tools developed to model and understand nucleic acid systems with the ultimate goal of being able to predict RNA structure. Since RNA typically folds hierarchically, we devised a general hierarchical sampling protocol that naturally explores RNA three-dimensional conformational space efficiently and can be used in concert with any force field, such as an RNA knowledgebased potential that we also discuss in this thesis. Additionally, we examined a clustering method that can assist analysis of structural models. Lastly, we applied our modeling techniques to study simple two-way RNA junctions with all-atom representation, and probed the modeled effects of sterics, chain connectivity and sequence on dynamic RNA behavior.
- Understanding and preventing anterior cruciate ligament injuries using novel motion analysis systems2011Ariel Veronica Dowling.The overall goal of this dissertation is to use novel motion analysis systems to investigate the underlying mechanisms that cause an anterior cruciate ligament (ACL) injury and then to explore movement modification methods that might prevent ACL injuries from occurring. Additionally, novel motion analysis systems can provide new information about ACL injuries and therefore should be used to help analyze these injuries from a different perspective. This thesis provides the results from multiple experimental studies that used two novel motion analysis systems to investigate the underlying causes of ACL injury and potential injury prevention methods. Using a markerless motion capture system, the first investigation determined that increasing the coefficient of friction of the shoe-surface condition will change a subject's movement strategies during a sidestep cutting task in specific ways that may increase the risk of ACL injury. This investigation provides a biomechanical basis for the increased incidence of ACL injuries on high friction surfaces, and suggests that females are more at risk for ACL injury when cutting on high friction surfaces. In terms of novel motion analysis systems, there is a need for simple, cost effective methods to identify athletes at a higher risk for ACL injury during jumping tasks. As such, the second study assessed the capacity of a wearable inertial-based system to evaluate ACL injury risk during jumping tasks. The proposed system measured the knee flexion angle and the trunk lean, and demonstrated good concurrent validity and discriminative performance in terms of the known risk factors for ACL injury. This study also reported the angular velocity of the thigh and shank segments during bilateral and unilateral drop jumps for the first time. Furthermore, this study illustrated that there is an association between the coronal segment angular velocity and knee abduction moment, and that the coronal segment angular velocity can differentiate between subjects at higher risk for ACL injury. Recent studies have shown that the incidence of ACL injury can be decreased through the use of intervention programs. Therefore, the objective for the final study was to determine if an independent inertial-based system can be used to modify jump landing mechanics in order to decrease the risk for ACL injury by providing real-time feedback based on known kinematic and kinetic injury risk factors. This study found that the subjects reduced their risk for ACL injury after training with the system because there were significant increases in the maximum knee flexion angle and the maximum trunk lean. The subjects also reduced their risk for injury by decreasing their thigh coronal angular velocity, which was correlated with a decrease in their knee abduction moment. This study suggests that an inertial-based system could be used for interventional training aimed at reducing the risk for ACL injury.
- 2006 CRCnetBASEedited by Roger Haslam, David Stubbs.
- 2013 OSO, Limited to 3 simultaneous usersedited by Sue Ziebland, Angela Coulter, Joseph D. Calabrese, and Louise Locock.Improving patient experience is a global priority for health policy-makers and care providers. This book critically examines the various ways in which people's experience of health and healthcare can be recorded, analysed and therefore improved.
- 2014 WHO"Surveillance data collected in vital registration and TB notification systems provide essential information about the TB epidemic and programmatic efforts to control the disease at both national and local levels. Analysis of these data can help programme managers and other staff to track the level of and trends in TB disease burden, detect outbreaks of disease and identify ways to improve existing TB prevention, diagnostic and treatment services. This book provides practical guidance on the analysis and use of such surveillance data, and is suitable for a wide range of people engaged in TB control. It was produced as a major collaborative effort as part of the work of the WHO's Global Task Force on TB Impact Measurement."-- back cover.Also available: Print – 2014
- 2008Jerry A. Dorsch, Susan E. Dorsch.This text once again takes readers step-by-step through all the basic anesthesia equipment. It includes comprehensive references and detailed discussions on the scientific fundamentals of anesthesia equipment, its design, and its optimal use. This thoroughly updated edition includes new information on suction devices, the magnetic resonance imaging environment, temperature monitoring and control, double-lumen tubes, emergency room airway equipment, and many other topics.
- Understanding antimicrobial exposure and clostridium difficile infection : implications of fluoroquinolone use2008guest editors: John G. Bartlett, Dale N. Gerding.
- pt. 1-2, 2008[edited by] Luca Mainardi, Leif Sörnmo, Sergio Cerutti.
- 2006 CRCnetBASEedited by Steven O. Moldin, John L.R. Rubenstein.Integrating basic and clinical neuroscience perspectives, this book presents a comprehensive perspective on state-of-the-art research in epidemiology, genetics, and clinical neuroscience and neural systems implicated in autism. This book seeks to stimulate new directions for autism research on etiology, pathophysiology, and the development of new drug treatment. An underlying theme focuses on the potential for future research given the availability of the human, mouse, and other genomes. The text also explores the role of autism in society, including health economics and advocacy issues of interest to legislators.
- 2008Marketa Zvelebil & Jeremy O. Baum.
- 2006 Springeredited by Sylvie E. Blondelle.
- Understanding biomechanical causes and functional mechanism of treatment for stiff-knee gait in cerebral palsy2011Melanie Diane Fox.Many children with cerebral palsy walk with a stiff knee gait, or a reduction and delay in swing phase knee flexion, which causes tripping or energy-inefficient compensatory movements. Since over-activity of the rectus femoris muscle is frequently implicated as the cause, a common treatment is transfer of the distal end of the rectus femoris from its insertion on the patella to a location behind the knee. Outcomes, though positive on average, vary among individuals, with some patients demonstrating unimproved or worsened knee flexion postoperatively. This variability is due in part to insufficient understanding of the biomechanical causes of stiff-knee gait and the functional effects of surgical treatment. The goal of this dissertation was to clarify the causes of stiff-knee gait and examine the biomechanical mechanism of improvement following rectus femoris transfer surgery. Swing-phase rectus femoris activity is commonly thought to cause of stiff-knee gait, despite evidence that many patients have excessive knee extension moments in preswing rather than swing phase. We compared the effects of preswing to swing phase activity of the rectus femoris on peak knee flexion in swing by creating and analyzing musculoskeletal simulations of subjects with stiff-knee gait. We found that in six out of ten subjects preswing rectus femoris activity had at least a 90% higher effect on peak knee flexion than swing phase rectus femoris activity, suggesting that preswing rectus femoris activity is an important factor limiting knee flexion in some subjects and should be examined to better determine the factors leading to stiff-knee gait. To understand how other muscles, besides rectus femoris, may limit knee flexion in stiff-knee gait, it is first necessary to understand how muscles coordinate successful swing phase knee flexion in unimpaired gait and how muscle contributions change with walking speed, since many stiff-knee subjects walk slowly. We analyzed simulations of unimpaired subjects walking at different speeds to determine the muscles that accelerated and decelerated knee flexion prior to swing. We found that preswing knee flexion acceleration was achieved primarily by the hip flexor muscles with help from biceps femoris short head, suggesting that weakness in these muscles may contribute to stiff-knee gait. Vasti and soleus decelerated knee flexion, suggesting over-activity in these muscles may contribute to stiff-knee gait. We also investigated the mechanism of improvement following rectus femoris transfer surgery. We altered the geometry of rectus femoris and simulated the dynamics of the swing phase of subjects with stiff-knee gait after different surgical procedures. Analysis of the simulations demonstrated that knee flexion may be improved with a reduction of the knee extension moment generated by the rectus femoris, even if the muscle is not converted to a knee flexor. This dissertation clarifies preswing rectus femoris activity as a cause of stiff-knee gait, demonstrates the functional mechanism of improvement following transfer surgery, and informs future research investigating other potential contributors to stiff-knee gait.
- 2006Hippokratis Kiaris.Some introductory concepts in tumor biology: clonal evolution and autonomy versus non-autonomy of cancer cells -- The cell's life and death: cell cycle, senescence and apoptosis -- Oncogenes -- Tumor-suppressor genes -- Genomic instability -- A twist in the (genetic) tail: cancer epigenetics -- Nonautonomous interactions in carcinogenesis: role of the tumor stroma -- Telomerase and cellular immortality -- tumor angiogenesis -- Metastasis -- Tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes -- Cancer stem cells -- Determination of therapeutic efficacy-pharmacogenomics -- Certain chemicals induce cancer: chemical carcinogenesis -- Hormones and cancer -- Viral oncogenesis -- Cooperation of multiple biological processes is needed for the development of fully fledged malignancy -- Carcinogenesis in vivo: animal models and basic approaches to generate genetically modified animals -- Multistage carcinogenesis in humans: molecular epidemiology and the colon cancer model -- Epilogue.
- Understanding clinical data analysis : learning statistical principles from published clinical research2016 SpringerTon J. Cleophas, Aeilko H. Zwinderman.Randomness -- Randomized and Observational Research -- Randomized Clinical Trials, history, Designs -- Randomized Clinical Trials, Analysis Sets, Statistical Analysis, Reporting Issues -- Discrete Data Analysis, Failure Time Data Analysis -- Quantitative Data Analysis -- Subgroup Analysis -- Interim Analysis -- Multiplicity Analysis -- Medical Statistics : a Discipline at the Interface of Biology and Mathematics.
- 2014 ebraryDavid Bowers, Allan House, David Owens, Bridgette Bewick.Understanding Clinical Papers is a popular and well established introduction to reading clinical papers. It unravels the process of evidence-based practice, using real papers to illustrate how to understand and evaluate published research, and provides clear explanations of important research-related topics.
- 2013 AccessMedicineeditors, Renato D. Lopes, Robert A. Harrington.Complete how-to guidance on conducting clinical research, this book addresses the operational challenges of clinical trials and provides a clear explanation of the methodologies necessary to interpret results. The book addresses all aspects of clinical trials, from design and implementation to statistics to regulatory scrutiny. A resource for students, residents, and clinicians who need a working knowledge of clinical research principles. The chapter authors are all leaders in the field and engaged in cutting edge clinical research. Use as a textbook, as a reference, and as a course guide for mandated clinical research training courses.
- 2007 CRCnetBASEedited by Lynn Frewer and Hans van Trijp ; sponsored by MATFORSK.pt. 1. Key influences on consumer food choice -- pt. 2. Product attributes and consumer food choice -- pt. 3. Diversity in consumer food choice: cultural and individual difference -- pt. 4. Consumers, food and health -- pt. 5. Consumer attitude, food policy and practice.
- 2014 Kargervolume editors, O. Hiort, S.F. Ahmed.Gonadal development / Lucas-Herald, A.K., Bashamboo, A. -- The masculinization programming window / Welsh, M., Suzuki, H., Yamada, G. -- Androgen action / Werner, R., Holterhus, P.-M. -- Steroid biochemistry / Kamrath, C., Wudy, S.A., Krone, N. -- Next generation sequencing for disorders of sex development / Tobias, E.S., McElreavey, K. -- Advances in neuroimaging / Rodie, M.E., Forbes, K.P., Muir, K. -- Imaging, endoscopy and diagnostic surgery / Wünsch, L., Buchholz, M. -- Fertility issues in the management of patients with disorders of sex development / Guercio, G., Rey, R.A. -- Disorders of sex development peer support / Baratz, A.B., Sharp, M.K., Sandberg, D.E. -- Improving the communication of healthcare professionals with affected children and adolescents / Nordenström, A., Thyen, U. -- Working with adolescents and young adults to support transition / Gleeson, H., Wisniewski, A.B. -- Past experiences of adults with disorders of sex development / GrApSIA, Audí, L. -- Sex hormone replacement in disorders of sex development / Birnbaum, W., Bertelloni, S. -- Hydrocortisone replacement in disorders of sex development / Blankenstein, O. -- Advances in molecular markers of germ cell cancer in patients with disorders of sex development / van der Zwan, Y.H., Cools, M., Looijenga, L.H.J. -- Managing the risk of germ cell tumourigenesis in disorders of sex development patients / Cools, M., Looijenga, L.H.J., Wolffenbuttel, K.P., T'Sjoen, G. -- Timing of hypospadias repair in patients with disorders of sex development / Springer, A., Baskin, L.S. -- Timing of surgery for feminizing genitoplasty in patients suffering from congenital adrenal hyperplasia / Eckoldt-Wolke, F. -- Timing of feminising surgery in disorder of sex development / Wolffenbuttel, K.P., Crouch, N.S. -- Phalloplasty : a panacea for 46,XY disorder of sex development conditions with penile deficiency? / Callens, N.; Hoebeke, P. -- Rare diseases research and practice / Polizzi, A., Balsamo, A., Bal, M.O., Taruscio, D. -- Achieving diagnostic certainty in resource-limited settings / Mazen, I., Raza, J. -- Global application of disorders of sex development-related electronic resources : e-learning, e-consultation and e-information sharing / Muscarella, M., Kranenburg-van Koppen, L., Grijpink-van den Biggelaar, K., Drop, S.L.S. -- International networks for supporting research and clinical care in the field of disorders of sex development / Ahmed, S.F., Bryce, J., Hiort, O.
- 2007 CRCnetBASEMario Grassi ... [et al.].Mathematical modeling -- Gastrointestinal tract and skin -- Rheology -- Mass transport -- Drug dissolution and partitioning -- Dissolution of crystallites: size effectson on the solubility -- Drug release from matrix systems -- Drug release from microemulsions -- Drug permeation through membranes.
- 2006 ScienceDirectedited by S. Anders ... [et al.].
- Understanding evidence-based rheumatology : a guide to interpreting criteria, drugs, trials, registries, and ethics2014 SpringerHasan Yazici, Yusuf Yazici, Emmanuel Lesaffre, editors.It is imperative that health professionals caring for patients with rheumatic diseases understand how to correctly interpret evidence in their field, taking into account the merits and shortcomings of available data. Understanding Evidence-Based Rheumatology offers a practical assessment of criteria, drugs, trials, and registries and provides useful tools for successfully interpreting this data. The book introduces readers to basic analysis of trial design, statistics, and application of data through no-nonsense, easy-to-follow insights. Using numerous examples, chapters outline the difficulties physicians encounter when measuring disease activity in rheumatology, and offer strategies for systematically approaching these situations. Ethical issues in study design and reporting are examined, and the book closes with a summary of future directions for scientific and clinical studies in rheumatology. Understanding Evidence-Based Rheumatology is an invaluable resource for trainees, experienced clinicians, and scientists, preparing them with the necessary tools to correctly gather evidence and shed light on the difficult practice of rheumatology.
- Understanding fluorescein angiography = : Fluoreszeinangiografie verstehen = Entendiendo angiografía con fluoresceína2006 SpringerManfred Spitznas ; traducción: Hugo Quiroz-Mercado.Also available: Print – 2006
- 2014 AccessMedicineedited by William H. Markle, Melanie A. Fisher, Raymond A. Smego, Jr.Global health : past, present and future / Amir A. Khaliq and Raymond A. Smego, Jr. -- The global burden of disease / Thuy D. Bui and William H. Markle -- Epidemiology, biostatistics, and surveillance / Christopher Martin -- The health of women/mothers and children / Judy Lewis, Monika Doshi, Deyanira Gonzalez de Leon, and Amany Refaat -- Human trafficking / Clydette Powell -- Environmental health in the global context / Jeffrey K. Griffiths and Edward Winant -- Nutrition / Clydette Powell and John R. Butterly -- Primary care in global health / Jeffrey F. Markuns and Alain J. Montegut -- Malaria / Paul R. Larson and Mark W. Meyer -- Tuberculosis and HIV/AIDS / Lisa V. Adams and Godfrey B. Woelk -- The neglected tropical diseases / Gregory Juckett -- Emerging diseases and antimicrobial resistance / Arif R. Sarwari and Rashida A. Khakoo -- Injury and global health / Jeffry P. McKinzie -- Surgical issues in global health / Eileen S. Natuzzi, et al. -- Humanitarian assistance and disaster relief / Sheri Fink, Vera Sistenich, and Clydette Powell -- Aging populations and chronic illness / Wayne A. Hale, Jane D. Joubert, and Sebastiana Kalula -- Global mental health : the world mental health surveys perspective / Jordi Alonso, Somnath Chatterji, Yanling He, Philip S. Wang, and Ronald C. Kessler -- Global health communications, social marketing, and emerging communication technologies / Gary Snyder -- Economics and global health / Kevin Chan -- Health systems, management, and organization in global health / David Zakus, Onil Bhattacharyya, and Xiaolin Wei -- Global health ethics / Anvar Velji and John H. Bryant -- Education and careers in global health / Jessica Evert and Scott Loeliger.
- Understanding health literacy and its barriers : January 1998 through November 2003, plus selected ear[l]ier and later citations : 651 citations2004 NLMUnited States National Library of Medicine, National Institutes of Health ; prepared by Marcia Zorn, Marin P. Allen, Alice M. Horowitz.Examines some of the barriers that may need to be addressed when designing strategies to connect the audience with appropriate health information materials, services, or resources.
- 2016 AccessMedicineThomas Bodenheimer, Kevin Grumbach.Introduction: the paradox of excess and deprivation -- Paying for health care -- Access to health care -- Paying health care providers -- How health care is organized-I: Primary, secondary, and tertiary care -- How health care is organized-II: Health delivery systems -- Health care workforce and the education of health professionals -- Painful versus painless cost control -- Mechanisms for controlling costs -- Quality of health care -- Prevention of illness -- Long-term care -- Medical ethics and rationing of health care -- Health care in four nations -- Health care reform and national health insurance -- Conflict and change in America's health care system -- Conclusion: tensions and challenges -- Questions and discussion topics.
- 2009Thomas S. Bodenheimer, Kevin Grumbach.
- 2012 AccessMedicineThomas Bodenheimer, Kevin Grumbach.Introduction: the paradox of excess and deprivation -- Paying for health care -- Access to health care -- Reimbursing health care providers -- How health care is organised--I: primary, secondary, and tertiary care -- How health care is organised--II: health delivery systems -- Health care workforce and the education of health professionals -- Painful versus painless cost control -- Mechanisms for controlling costs -- Quality of health care -- Prevention of illness -- Long-term care -- Medical ethics and rationing of health care -- Health care in four nations -- Health care reform and national health insurance -- Conflict and change in America's health care system -- Conclusion: tensions and challenges -- Questions and discussion topics.
- 2011Ann Gee Lisa Ooi.Recent technological advances in high throughput technology, sample preparation and data analysis have made whole genome mRNA and miRNA analysis of purified hematopoietic cell populations much more accessible. The high throughput analysis of the hematopoietic stem cell (HSC) population has yielded massive amounts of data and now we are in the process of biologically validating these targets. Esam1 is one target yielded from microarray analysis of the HSC population. We found Esam1 to be highly and selectively expressed by HSC from mouse bone marrow. Esam1 is also a viable positive HSC marker in fetal, young and aged mice, as well as in mice of several different strains. In addition, we find robust levels of Esam1 transcripts in purified human HSC. Esam1-/- mice do not exhibit severe hematopoietic defects, however, Esam1-/- BM has an increased frequency of HSC and fewer T cells. HSC from Esam1-/- mice give rise to more granulocyte/monocytes in culture and a higher T cell:B cell ratio upon transplantation into congenic mice. These studies identify Esam1 as a novel, widely applicable HSC-selective marker and suggest that Esam1 may play roles in both HSC proliferation and lineage decisions. MicroRNA-125b (miR-125b) is a target yielded from miRNA profiling of the HSC population. We show that miR-125b is highly expressed in HSC and its expression decreases in committed progenitors. Overexpression of miR-125b in mouse HSC enhances their function, demonstrated through serial transplantation of highly purified HSC, and enriches for the previously described Slamf1lo CD34- lymphoid balanced and the Slamf1negCD34- lymphoid biased cell subsets within the multipotent HSC [CD34-KLS] fraction. This enrichment of HSC subsets occur via an anti-apoptotic mechanism, reducing the mRNA expression levels of two pro-apoptotic targets, Bmf and KLF13. The anti-apoptotic effect of miR-125b is more pronounced in the lymphoid biased HSC subset because of their intrinsic higher baseline levels of apoptosis. Together, these data reveal that miR-125b regulates hematopoietic stem cell survival and can promote lymphoid fate decisions at the level of the HSC by preferentially expanding lymphoid balanced and lymphoid biased HSC.
- 2016 SpringerHugh Rayner, Mark Thomas and David Milford.1. Kidney anatomy and physiology: the basis of clinical nephrology -- 2. Measuring kidney funciton: quantifying glomerular filtration from laboratory tests -- 4. How are you feeling? The symptoms of uraemia -- 5. Do you have any long-term health conditions? Kidney involvement in multisystem diseases -- 6. Are you pregnant or planning a pregnancy? How pregnancy affects the kidneys and vice versa -- 7. What is your family history? The molecular genetics of inherited kidney diseases -- 8. What have you been taking? Nephrotoxicity from medications and other chemicals -- 9. Height and weight: the effects of kidney disease on body size and composition -- 10. Blood pressure: a common theme in kidney disease -- 11. Test the urine: understanding haematuria, proteinuria and urinary infection -- 13. Full blood count, urea and electrolytes, bicarbonate, bone profile: laboratory results and kidney diseases -- 14. Immunology: serological tests that help diagnose kidney diseases -- 15. Image the urinary tract: strengths and weaknesses of different radiology modalities -- 16. Shoud we do a kidney biopsy? Balancing the diagnostic benefits against the clinical risks -- 17. Make a plan: when and how to prepare for end-stage kidney disease -- 18. Renal replacement therapy: common problems in dialysis and transplant patients -- 19. Epilogue: scaling-up kidney care from one individual to whole population -- Multiple choice questions -- Multiple choice question answers -- Index of case reports -- Index of histopathology, radiology and clinical images -- Index.
- 2014 SpringerBrian I. Carr.Understanding Liver Cancer is a concise and up-to-date review, which discusses diagnosis, management, patient care, current and emerging therapies, and useful resources that clinicians can provide to their patients. Busy healthcare professionals who want a quick review of liver cancer as well as a summary of current therapies will benefit from this succinct text.
- written by Betty Furrie, in conjunction with the Data Base Development Department of the Follet Softward Company ; reviewed and edited by the Network Development and MARC Standards Office, Library of Congress.
- 2010 SpringerAshfaq Hasan.Historical Aspects of Mechanical Ventilation / Ashfaq Hasan -- The Indications for Mechanical Ventilation / Ashfaq Hasan -- Physiological Considerations in the Mechanically Ventilated Patient / Ashfaq Hasan -- The Conventional Modes of Mechanical Ventilation / Ashfaq Hasan -- Ventilator Settings / Ashfaq Hasan -- Ventilator Alarms / Ashfaq Hasan -- Monitoring Gas Exchange in the Mechanically Ventilated Patient / Ashfaq Hasan -- Monitoring Lung Mechanics in the Mechanically Ventilated Patient / Ashfaq Hasan -- Mechanical Ventilation in Specific Disorders / Ashfaq Hasan -- The Complications of Mechanical Ventilation / Ashfaq Hasan -- Ventilator-Associated Pneumonia / Ashfaq Hasan -- Discontinuation of Mechanical Ventilation / Ashfaq Hasan -- Noninvasive Ventilation in Acute Respiratory Failure / Ashfaq Hasan -- Negative Pressure Ventilation / Ashfaq Hasan -- Airway Humidification in the Mechanically Ventilated Patient / Ashfaq Hasan -- Aerosol Therapy in the Mechanically Ventilated Patient / Ashfaq Hasan -- Nonconventional Modes and Adjunctive Therapies for Mechanical Ventilation / Ashfaq Hasan -- Case Studies / Ashfaq Hasan.
- 2008Daniel Lee Chao.
- 2014 ebraryedited by Tim Swanwick.Understanding medical education / Tim Swanwick -- Teaching and learning in medical education: how theory can inform practice / David M Kaufman and Karen V. Mann -- Principles of curriculum design / Janet Grant -- Quality in medical education / Alan Bleakley, Julie Browne and Kate Ellis -- Problem-based learning / Mark A Albanese -- Interprofessional education / Della Freeth -- Work-based learning / Clare Morris and David Blaney -- Supervision, mentoring and coaching / John Launer -- Teaching and leading small groups / Peter McCrorie -- Lectures and large groups / Andrew Long and Bridget Lock -- Technology-enhanced learning / Alison Bullock and Peter de Jong -- E-learning / Scott Rice and Jean McKendree -- Simulation in medical education / Jean Ker and Paul Bradley -- Portfolios in personal and professional development / Erik Driessen and Jan van Tartwijk -- Self-regulated learning in medical education / Casey B. White, Larry D.Gruppen and Joseph C. Fantone -- Learning medicine from the humanities / J. Jill Gordon and H. Martyn Evans -- Patient involvement in medical education / John Spencer and Judy McKimm -- How to design a useful test: the principles of assessment / Lambert WT Schuwirth and Cees PM van der Vleuten -- Written assessment / Brian Jolly -- Workplace assessment / John J Norcini -- Structured assessments of clinical competence / Katharine A. M. Boursicot, Trudie E Roberts and William P Burdick -- Standard setting methods in medical education / Andr F. De Champlain -- Formative assessment / Diana F Wood -- Thinking about research: theoretical perspectives, ethics and scholarship / Jan Illing -- Quantitative research methods in medical education / Geoff Norman and Kevin W Eva -- Qualitative research in medical education: methodologies and methods / Lorelei Lingard, Tara J. Kennedy and Stella Ng -- Programme evaluation: improving practice, influencing policy and decision-making / Chris Lovato and David Wall -- Selection into medical education and training / Fiona Patterson , Eammon Ferguson and Alec Knight -- Career progression and support / Caroline Elton and Nicole J. Borges -- Managing remediation / Deborah Cohen, Melody Rhydderch and Ian Cooper -- Dealing with diversity / Anthony Americano and Dinesh Bhugra -- Developing medical educators: a journey, not a destination / Yvonne Steinart -- Educational leadership / Judy McKimm and Tim Swanwick.
- Ubiquitin and protein degradation. Part A-B — Understanding medical education : evidence, theory, and practice. Second edition. [2nd ed.] (100)
- Understanding medical education : evidence, theory and practice. 1st ed. — U.S. decennial life tables for 1989-91. Volume II, State life tables (100)
- U.S. health in international perspective : shorter lives, poorer health — Uveitis-- fundamentals and clinical practice. 4th ed. (50)
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- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
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