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  • This volume delivers broad, practical knowledge of trauma diagnosis and management in a high-yield format that enables quick mastery of the material. A consistent organization by body region, summary tables and boxes, bulleted lists, and detailed artwork make this reference perfect for quick review of the essential knowledge.
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  • Trauma. 7th ed. 2013
    AccessSurgery
    Kinematics -- Epidemiology -- Injury prevention -- Trauma systems, triage, and transport -- Injury severity scoring and outcomes research -- Acute care surgery -- Prehospital care -- Disaster and mass causalty -- Rural trauma -- Initial assessment and management -- Airway management -- Management of shock -- Postinjury hemotherapy and hemostasis -- Emergency department thoracotomy -- Diagnostic and interventional radiology -- Surgeon-performed ultrasound in acute care surgery -- Principles of anesthesia and pain management -- Infectons -- Injury to the brain -- Eye -- Face -- Neck -- Vertebrae and spinal cord -- Trauma thoracotomy: principles and techniques -- Lung, trachea, and esophagus -- Heart and thoracic vascular injuries -- Trauma laparotomy: principles and techniques -- Diaphragm -- Liver and biliary tract -- Injury to the spleen -- Stomach and small bowel -- Doudenum and pancreas -- Colon and rectal trauma -- Abdominal vascular injury -- Pelvis -- Genitourinary trauma -- Trauma in pregnancy -- Trauma damage control -- Upper extremity -- Lower extremity -- Periphearl vascular injury -- Alcohol and drugs -- The pediatric patient -- The geriatric patient -- Ethics of acute care surgery -- Social violence -- Wounds, bites, and stings -- Burns and radiation -- Temperature-related syndromes: hyperthermia, hypothermia, and frostbite -- Organ procurement for transplantation -- Rehabilitation -- Modern combat casualty care -- Genomics and acute care surgery -- Trauma, medicine, and the law -- Principles of critical care -- Cardiovascular failure -- Respiratory insufficiency -- Gastrointestinal failure -- Renal failure -- Nutritional support and electrolyte management -- Multiple organ failure.
  • Overview of TBI / David F. Moore, Michael S. Jaffee, Geoffrey Ling -- Imaging diagnosis of TBI / Tuong H. Le, Shirley I. Stiver, Alisa D. Gean -- Neurocognitive assessment of mTBI / W. Huw Williams, Seb Potter, Helen Ryland, Philip Yates, James Tonks & Adam Reuben -- Management of moderate and severe TBI / Scott A. Marshall, Randy Bell, Rocco A. Armonda, Geoffrey S.F. Ling -- Sports concussion / Sharon R. Weeks, Jack W. Tsao -- Blast-related concussion / Carson Lawall -- Sleep/wake disturbances in mild traumatic brain injury patients / Michael Russo, Aimee Alphonso, Ian Murphy -- Vestibular consequences of mTBI / Michael E Hoffer, Kim Gottshall, Erik S. Viirre -- Post-traumatic headache / Jay C. Erickson, Brett J. Theeler -- Seizures after TBI / John Betjemann, Karen Parko -- Endocrine disturbances following TBI / Victoria Tepe, Arthur Guerrero -- Confronting mild TBI and Co-occurring PTSD symptoms in combat deployed service members / Justin S. Campbell, Jeffrey H. Greenberg, Jennifer M. Weil -- Behavioral and psychiatric comorbidities of TBI / Robert L. Collins, Nicholas J. Pastorek, Andra L. Teten, Thomas A. Kent -- Rehabilitation of TBI / Mel Glenn -- Interventions to improve cognitive functioning after TBI / Anthony J.-W. Chen, Tatjana Novakovic-Agopian -- Current diagnostic and therapeutic challenges / Donald W. Marion.
  • Traumatic brain injury. Parts I-II pt. 1-2, 2015
    ScienceDirect
    pt. 2 ScienceDirect
    The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.
  • Distal femoral fractures -- Tibial plateau fractures -- Patellar fractures -- Patellar dislocations and osteochondral fractures -- Traumatic knee dislocation -- Floating knee -- Nonunion and malunion around the knee -- Knee extensor mechanism injuries -- Anterior cruciate ligament (ACL) injuries -- Runner's knee and pataellar tendinopathy.
  • "Treatment of traumatic injuries is increasing in importance for physical therapists active in hospitals and private practice. In addition to the bone, joint, and soft tissue injuries incurred in sports, physical therapists are seeing more and more traumas associated with aging and with high-speed accidents. This great variety of injury types increases the complexity of treatment. Moreover, in recent years there has been a growing demand for the most complete restoration possible of both physical and psychological function. This is the principal objective of aftercare. Accordingly, this book focuses on a comprehensive presentation of individual injuries and their effect on function, as well as the guidelines and potential results of physical therapy treatment. It is addressed to students, practitioners, and teachers of physical therapy who must master and apply an understanding of the whole range of injuries, their consequences, and their treatment. "--Provided by publisher.
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  • Here₂s a handy, portable guide to preventing, evaluating, and managing diseases that can be acquired in tropical environments and foreign countries! Whether you₂re a physician, traveler, or both, this respected manual is your perfect source for quick, easy access to the latest travel medicine information. New updates and additional material are presented in a sleek new design that offers rapid access to the content you need. The fourth edition features more critical content than ever before--including new evidence-based recommendations and new maps and illustrations. From pre-travel advice and immunizations to the diagnosis and treatment of a full range of travel-related illnesses, you₂ll have all the information you need to avoid, recognize, and treat illnesses acquired away from home in a convenient, pocket size guide. Illustrates key concepts with visual guidance from dynamic new images. Offers evidence-based treatment recommendations to enable you to manage diseases confidently. Provides access to need-to-know information quickly in a convenient, pocket size for excellent portability. Features 7 major sections, color-coded for quick answers: Pre-travel Advice Advice for Special Travelers Fever Diarrhea Skin Lesions Sexually Transmitted Diseases Worms.
  • Travel medicine. 3rd ed. 2013
    ClinicalKey
    This 3rd Edition, by Jay S. Keystone, Phyllis E. Kozarsky, David O. Freedman, Hans D. Nothdruft, and Bradley A. Connor, prepares you and your patients for any travel-related illness they may encounter. Consult this resource for best practices on everything from immunizations and pre-travel advice to essential post-travel screening. From domestic cruises to far-flung destinations, this guide offers a wealth of practical guidance on all aspects of travel medicine. New to this edition: Effectively protect your patients before they travel with new information on immunizations and emerging and re-emerging disease strains, including traveler's thrombosis. Update your knowledge of remote destinations and the unique perils they present. Stay abreast of best practices for key patient populations, with new chapters on the migrant patient, humanitarian aid workers, medical tourism, and mass gatherings, as well as updated information on pediatric and adolescent patients.
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    General principles / Hans Steiner, Rebecca Hall, Julia Huemer -- Disruptive behavior disorders / Whitney Daniels, Michael Kelly, Kathleen Ares, Katie Kaszynski, Niranjan Karnik -- Attention-deficit/hyperactivity disorder (ADHD) / Michael Kelly -- Learning and executive cognitive functions / Ahmed Khan, Brianna Bendixsen, Lynne Baldwin, Diana Barrett, Richard Abbey.
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  • Intends to conceptualize aggression as a symptom of underlying behavioural and emotional problems and examines the psychology of perpetrators and the power dynamics that foster intentionally hurtful behaviour in young people. This book details how bibliotherapy offers relevant treatment and can be implemented with individuals and groups.
  • History of treatment in children with developmental disabilities and psychopathology / Jonathan Wilkins and Johnny L. Matson -- Applied behavior analysis and the treatment of childhood psychopathology and developmental disabilities / Joel E. Ringdahl and Terry S. Falcomata -- Cognitive behavior therapy / Ellen Flannery-Schroeder and Alexis N. Lamb -- Parent-training interventions / Nicholas Long, Mark C. Edwards, and Jayne Bellando -- Conduct disorders / Christopher T. Barry ... [et al.] -- Treatment of Attention-deficit/hyperactivity disorder (ADHD) / Ditza Zachor, Bart Hodgens, and Cryshelle Patterson -- PTSD, anxiety, and phobia / Thompson E. Davis III -- Treatment strategies for depression in youth / Martha C. Tompson and Kathryn Dingman Boger -- Medication treatment of bipolar disorder in developmentally disabled children and adolescents / Zinoviy A. Gutkovich and Gabrielle A. Carlson -- Treatment of autism spectrum disorders / Mary Jane Weiss, Kate Fiske, and Suzannah Ferraioli -- Treatment of self-injurious behaviour in children with intellectual disabilities / Frederick Furniss and Asit B. Biswas -- Communication, language, and literacy learning in children with developmental disabilities / Erna Alant, Kitty Uys, and Kerstin Tönsing -- Eating disorders / David H. Gleaves, Janet D. Latner, and Suman Ambwani -- Treatment of pediatric feeding disorders / Cathleen C. Piazza, Henry S. Roane, and Heather J. Kadey.
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  • Malaria has defeated previous efforts at eradication and remains a massive global public health problem despite being readily preventable and treatable. It is a devastating disease that also extracts huge economic costs from the poorest countries in endemic regions. Starting with an overview of the disease and its current political, financial and technical context, this Milestones in Drug Therapy volume describes the history, chemistry, mechanisms of action and resistance, preclinical and clinical use, pharmacokinetics and safety and tolerability of the current range of antimalarial drugs. There is particular emphasis on artemisinins and related peroxides, as these drugs have now become the frontline treatment for malaria. Next generation antimalarials, molecular markers for detecting resistance, the importance of diagnostics and disease prevention are also covered in detail.
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  • "This indispensable manual presents the Maudsley method, the leading family-based treatment for adolescents with anorexia nervosa (AN). What sets this approach apart is the central role played by parents throughout treatment. The authors are prominent experts who describe how to mobilize families to promote the patient's weight restoration and healthy eating, improve parent-child relationships, and get adolescent development back on track. Each phase of therapy is described in session-by-session detail. In-depth case illustrations show how to engage clients while flexibly implementing the validated treatment procedures"-- Provided by publisher.
  • OBJECTIVES: There are two generally accepted strategies for managing atrial fibrillation (AF): rate control and rhythm control. However, within each strategic approach there are a large number of potential pharmacological and nonpharmacological therapies, and the comparative safety and effectiveness of these therapies--both within and between strategies--are uncertain. DATA SOURCES: We searched PubMed(r), Embase(r), and the Cochrane Database of Systematic Reviews for relevant English-language comparative studies. REVIEW METHODS: Two investigators screened each abstract and full-text article for inclusion, abstracted data, rated quality and applicability, and graded evidence. When possible, random-effects models were used to compute summary estimates of effects. RESULTS: Our review included 182 articles (148 unique studies): 14 studies relevant to rate-control drugs, 3 relevant to strict versus lenient rate control, 6 relevant to rate-control procedures versus drugs in patients for whom initial pharmacotherapy was ineffective, 42 relevant to antiarrhythmic drugs and electrical cardioversion for conversion to sinus rhythm, 83 relevant to rhythm-control procedures and drugs for maintenance of sinus rhythm, and 14 focusing on the comparison of rate- and rhythm-control strategies. Our ability to draw conclusions for the Key Questions addressing rate-control strategies was limited by the small number of available studies that assessed comparable therapies and outcomes, although we found a high strength of evidence for consistent benefit of calcium channel blockers (verapamil or diltiazem) compared with digoxin for ventricular rate control. For comparisons of methods for electrical cardioversion for conversion to sinus rhythm, there was high strength of evidence that use of a single biphasic waveform was more effective than use of a single monophasic waveform (odds ratio [OR] 4.39; 95% confidence interval [CI], 2.84 to 6.78) and that a 200 Joules (J) biphasic shock was less effective than a 360 J monophasic shock (OR 0.16; 95% CI, 0.05 to 0.53). Drug enhancement of external electrical cardioversion demonstrated a benefit compared with no drug enhancement (moderate strength of evidence), but data evaluating whether any one antiarrhythmic agent was more effective than others at restoring sinus rhythm were inconclusive. Our review found high strength of evidence supporting pulmonary vein isolation (PVI) versus antiarrhythmic drugs for maintenance of sinus rhythm in a select subset of patients (those with paroxysmal AF who were younger and with no more than mild structural heart disease; OR 6.51; 95% CI, 3.22 to 13.16) and moderate strength of evidence for adding a surgical Maze procedure at the time of other cardiac surgery (specifically mitral valve surgery) as opposed to mitral valve surgery alone (OR 5.80; 95% CI, 1.79 to 18.81). Comparing rate- and rhythm-control strategies, there was moderate strength of evidence supporting comparable efficacy with regard to all-cause mortality (OR 1.34; 95% CI, 0.89 to 2.02); cardiovascular mortality (OR 0.96; 95% CI, 0.77 to 1.20); stroke (OR 0.99; 95% CI, 0.76 to 1.30); and bleeding events (OR 1.10; 95% CI, 0.87 to 1.38). Cardiovascular hospitalizations were lower with rate-control strategies than with rhythm-control strategies (OR 0.25; 95% CI, 0.14 to 0.43; high strength of evidence). We were unable to conclude whether treatment effects varied by patient characteristics due to the paucity of studies that focused on specific patient subgroups. CONCLUSIONS: In assessing clinical outcomes associated with rate- versus rhythm-control strategies, our review of recent evidence agrees with prior reviews demonstrating little overall difference in outcomes between these two strategic approaches. Uncertainties still exist within specific subgroups of interest, among the wide variety of pharmacological and procedural therapies within each strategic approach, and in the impact of strategies on long-term clinical outcomes. Specifically, our review highlights the need for additional studies evaluating final outcomes such as mortality, stroke, and cardiovascular hospitalizations.
  • Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered.These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners.
  • 1. Pain as a Perceptual Experience -- 2. Neuroplasticity, Sensitization, and Pain -- 3. Muscle Pain Treatment -- 4. Addictive Disorders and Pain -- 5. The "Five-Minute" Mental Status Examination of Persons with Pain -- 6. The Psychological Assessment of Patients with Chronic Pain -- 7. Psychological Therapies -- 8. Billing Psychological Services for Patients with Chronic Pain -- 9. Hypnosis and Pain Control -- 10. Acupuncture -- 11. Manual Therapies -- 12. Treatment of Chronic Painful Musculoskeletal Injuries and Diseases with Regenerative Injection Therapy (RIT): Regenerative Injection Therapy Principles and Practice -- 13. Interdisciplinary Functional Restoration and Pain Programs -- 14. Pain and Spirituality -- 15. Pain Disparity: Assessment and Traditional Medicine -- 16. Sleep and Chronic Pain -- 17. Empowerment: A Pain Caregiver?s Perspective -- 18. Patient and Caregiver?s Perspective -- 19. Pain Medicine in Older Adults: How Should It Differ? -- 20. Pain Medicine and Primary Care: The Evolution of a Population-Based Approach to Chronic Pain as a Public Health Problem -- 21. Pain Care Beyond the Medical Practice Office: Utilizing Patient Advocacy, Education, and Support Organizations -- 22. Neonatal Pain -- 23. Assessing Disability in the Pain Patient -- 24. The Double Effect: In Theory and in Practice -- 25. Failure to Treat Pain.
  • 1. A Survey of Systems Involved in Nociceptive Processing -- 2. Pharmacogenomics of Pain Management -- 3. Nonsteroidal Anti-inflammatory Drugs -- 4. The Role of Antidepressants in the Treatment of Chronic Pain -- 5. Anticonvulsant Medications for Treatment of Neuropathic and "Functional" Pain -- 6. NMDA Receptor Antagonists in the Treatment of Pain -- 7. Role of Muscle Relaxants in the Treatment of Pain -- 8. Topical Analgesics -- 9. Sleep Aids -- 10. Clinical Use of Opioids -- 11. Opioid Adverse Effects and Opioid-Induced Hypogonadism -- 12. Acute Management of the Opioid-Dependent Patient -- 13. Opioids and the Law -- 14. Methadone for Chronic Pain -- 15. Toxicology Screening for Opioids -- 16. Monitoring Drug Use and Abuse: The Evolution of a Paradigm -- 17. Polypharmacy and Drug Interaction -- 18. Role of Cannabinoids in Pain Management -- 19. The Future of Pain Pharmacotherapy.
  • Development of moisturizers is a scientific and artistic discipline, where consumer insights are also needed. This new book bridges the gap between the moisturizers and the skin by covering all the essential information required to tailor the use of moisturizers to particular disorders and patients. Important aspects of skin biochemistry and barrier function are explained, and the ingredients and treatment effects of moisturizers are explored in depth. Careful attention is paid to controversies, including the role of certain moisturizers in inducing dryness/eczema, asthma, and comedones. The information provided in this unique book will enable the reader to go beyond the traditional thinking regarding skin care. The novel insights offered will suggest the properties required for a new generation of moisturizing treatments that more effectively improve the quality of life.
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    v. 1. Worldwide evidence 1985-1990.
  • I. Bridging the Gap : The Overview -- -- A perfect biopsychosocial storm : gender, culture, and eating disorders / Margo Maine and Douglas W. Bunnell -- What's weight go to do with it? Weight neutrality in the health at every size paradigm and its implications for clinical practice / Deborah Burgard -- Neuroscience : contributions to the understanding and treatment of eating disorders / Francine Lapides -- Are media an important medium for clinicians? Mass media, eating disorders, and the bolder model of treatment, prevention, and advocacy / Michael P. Levine -- -- II. Bridging the Gap : Diagnosis and Treatment -- -- The assessment process : refining the clinical evaluation of patients with eating disorders / Drew A. Anderson, Jackson M. Lavender, and Kyle P. De Young -- Medical assessment of eating disorders / Edward P. Tyson -- Psychiatric medication : management, myths, and mistakes / Martha M. Peaslee Levine and Richard L. Levine -- Nutritional impact on the recovery process / Jillian K. Croll -- Science or art? Integrating symptom management into psychodynamic treatment of eating disorders / Nancy L. Cloak and Pauline S. Powers -- New pathways : applying acceptance and commitment therapy to the treatment of eating disorders / Kathy Kater -- Outpatient treatment of anorexia nervosa following weight restoration : practical and conceptual issues / Richard A. Gordon -- Recipe for recovery : necessary ingredients for the client's and clinician's success / Beth Hartman McGilley and Jacqueline K. Szablewski -- -- III. Bridging the Gap : Special Populations -- -- Borderline personlity and eating disorders : a chaotic crossroads / Randy A. Sansone and Lori A. Sansone -- Managing the eating disorder patient with a comorbid substance use disorder / Amy Baker Dennis and Bethany L. Helfman -- Comorbid trauma and eating disorders : treatment considerations and recommendations for a vulnerable population / Diann M. Ackard and Timothy D. Brewster -- Healing self-inflicted violence in adolescents with eating disorders : a unified treatment approach / Kimberly Dennis and Jancey Wickstrom -- The weight-bearing years : eating disorders and body image despair in adult women / Margo Maine -- Men with eating disorders : the art and science of treatment engagement / Douglas W. Bunnell IV. Bridging the Gap : Family Issues -- -- Mutuality and motivation in the treatiment of eating disorders : connecting with patients and families for change / Mary Tantillo and Jennifer Sanftner -- When helping hurts : the role of the family and significant others in the treatment of eating disorders / Judith Brisman -- The most painful gaps : family perspectives on the treatment of eating disorders / Robbie Munn ... [et al.] -- -- V. Bridging the Gap : Mind, Body, and Spirit -- -- The role of spirituality in eating disorder treatment and recovery / Michael E. Berrett, Randy K. Hardman and P. Scott Richards -- The case for integrating mindfulness in the treatment of eating disorders / Kimberli McCallum -- The use of holistic methods to integrate the shattered self / Adrienne Ressler, Susan Kleinman and Elisa Mott -- Incorporating exercise into eating disorder treatment and recovery : cultivating a mindful approach / Rachel M. Calogero and Kelly N. Pedrotty-Stump -- Body talk : the use of metaphor and storytelling in body image treatment / Anita Johnston -- -- VI. Bridging the Gap : Future Direction -- -- The research/practice gap : challenges and opportunities for the eating disorder treatment professional / Judith D. Banker and Kelly L. Klump.
  • 1. Anatomy and Biomechanics of the Elbow / A. Celli -- 2. The Clinical Examination of the Elbow / A. Hinssche, D. Stanley -- 3. Imaging of the Elbow / V. Spina, L. Baldini -- 4. Elbow Surgical Approaches / A. Celli, L. Celli -- 5. The Treatment of Distal Humerus Fractures / S.W. O'Driscoll -- 6. The Fractures of the Olecranon / J.E. Adams, S.P. Steinmann -- 7. The Radial Head Fractures / M.W. Hartman, S.P. Steinmann -- 8. The Treatment of Coronoid Fractures and their Complications / A.G. Schneeberger -- 9. Lateral Collateral Ligament Injury / D. Stanley -- 10. The Complex Dislocations of the Elbow / G.J.W. King -- 11. The Fracture-Dislocation of the Forearm (Monteggia and Essex-Lopresti Lesions) / A. Celli, M.C. Marongiu, M. Fontana, L. Celli -- 12. The Instability after Radial Head Excision / S.L. Jensen -- 13. The Radial Head Prosthesis: Historical Perspective / C. Rovesta, C. Minervini, G. Bonanno, L. Celli -- 14. The Swanson Radial Head Prosthesis / B. Martinelli -- 15. Bipolar Radial Head Prosthesis / A. Celli -- 16. Evolve Modular Metallic Radial Head Arthroplasty / G.J.W. King -- 17. Radial Head Prosthetic Replacement with the Avanta Implant / B.F. Morrey -- 18. Radial Head Replacement with a Pyrocarbon Head Prothesis: Preliminary Results of a Multicentric Prospective Study / Y. Allieu, M. Winter, J.P. Pequignot, P. De Mourgues -- 19. Elbow Stiffness / A. Celli, L. Celli -- 20. The Arthroscopic Treatment of the Stiff Elbow / S.W. O'Driscoll -- 21. The Surgery of Neglected Distal Humerus Fractures in Children and Adults / L.P. Müller, M. Hansen, B.F. Morrey, K.J. Prommersberger, P.M. Rommens -- 22. Total Elbow Replacement for Rheumatoid Arthritis / B.F. Morrey -- 23. Total Elbow Arthroplasty in Acute Fracture / A. Celli -- 24. Latitude Convertible Total Elbow Prosthesis / G.J.W. King, K. Yamaguchi, S.W. O'Driscoll -- 25. Total Elbow Arthroplasty for Post-traumatic Arthrosis / A.G. Schneeberger, B.F. Morrey -- 26. Revision of Failed Elbow Arthroplasty / B.F. Morrey -- 27. Elbow Nerve Tunnel Syndromes / A. Celli, C. Rovesta, M.C. Marongiu -- 28. Traumatic Isolated Lesions of Musculocutaneous Nerve / C. Rovesta, M.C. Marongiu, G. Bonanno, A. Celli, L. Celli -- 29. The Traumatic Nerve-Vascular Lesions / R. Adani, G. Leo, L. Tarallo -- 30. The Utility of Continuous Axial Brachial Plexus Catheters after Surgery / F. Gazzotti, L.V. Indrizzi, G. Magni, E. Bertellini, A. Tassi -- 31. Elbow Brace in Physical Therapy / R. Rotini, A. Marinelli.
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  • This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds.
  • Venous anatomy, physiology and pathophysiology -- Presentations of venous disease -- Patient evaluation: history and physical examination -- Lower extremity ultrasound: diagnostic and therapeutic applications -- Overview of therapy for leg veins -- Sclerotherapy -- Laser surgery -- Ambulatory phlebectomy -- Endovenous thermal ablation -- Venous stripping and subfascial endoscopic perforator surgery (SEPS) -- Indications for surgery today: an historic review of varicose vein treatment -- Compression therapy.
  • Lung cancer is the leading cause of cancer death in both men and women in the United States, and male Veterans seeking care at VA hospitals have a much higher age-specific incidence of lung cancer than males in the general population. The personal and economic significance of lung cancer has led to a vast research endeavor to try and identify new and more effective treatments. Most patients with lung cancer are diagnosed when the cancer is already advanced (stage IIIB or IV), and they are no longer candidates for surgical resection. Small cell lung cancer and non-small cell lung cancer (NSCLC) are different diseases in terms of treatment. Until recently, all therapies for advanced NSCLC were based on their cytotoxic properties. In the last few years, several novel agents aimed at specific molecular targets have been developed. This review was requested to evaluate the current evidence on the effectiveness and cost-effectiveness of treatments for advanced lung cancer.
  • This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authorsℓ́ℓ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.
  • Any surgical intervention, elective or acute, may lead to postoperative complications. Moreover, the pertaining approach - laparoscopic or open - will probably not differ in the morbidity rate after surgery. Complications that occur after a surgical intervention can be classified as major or minor. Major complications to the digestive tract after surgery imply in most of cases a leakage of an anastomosis, bleeding in the abdominal cavity or in the tract, the appearance of intraperitoneal abscesses, or surgical site infections and wound dehiscence. These complications, depending on the organ affected, upper GI, HPB tract or colorectal, are associated with high morbidity and mortality. Early suspicion and diagnosis, followed by an early and effective treatment is imperative in order to reduce the morbidity and mortality. Adequate treatment will involve a good coordination of the three disciplines involved in treatment: the surgeon, the intervention radiologist, and the gastroenterologist. Approach of these postoperative complications is changing constantly and these changes are not properly known by general and more specialized digestive surgeons daily involved in the treatment of these diseases. The proposal for this book is to offer a systematic description of the most frequent complications occurring in the three above mentioned parts of the digestive tract. In this way, the reader will have access to a practical book in which every current complication can be easily recognized, along with relevant information as guide for an adequate treatment.
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  • Treatment of Skin Disease is your definitive source for managing the complete range of dermatologic conditions you're likely to encounter in practice. This medical reference book boasts an intuitive and easy to use format that covers the full spectrum of options, equipping you with not only standard treatment strategies, but second- and third-line therapies for instances when other alternatives fail. You'll be thoroughly prepared to offer your patients the expertly informed medical care they deserve when facing common or complex dermatologic diseases. Address your most difficult clinical challenges by having every possible therapy option at your disposal, including third- and fourth-line therapies, as well as standard treatments for dermatologic disorders. Apply the in-depth knowledge of leading dermatologists through a summary of each treatment strategy along with detailed discussions of treatment choices. Gain insight to the essential features which define each dermatologic disease with chapters presented in a tabular format, using checklists of diagnostic and investigative pearls and color-coded boxed text, for quick at-a-glance summaries of key details. Seamlessly search the full text and access the Gold Standard drug database online at Expert Consult.
  • This is a timely and informative updated volume for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, Treatment of the Obese Patient, Second Edition is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient, Second Edition, is an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.
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  • Creating clinical guidelines is a modern trend. Published studies pertaining to a given theme are collected, their credibility evaluated, and then treatment options in the form of evidence-based guidelines are offered. There are a number of guidelines for the treatment of thyroid tumors that have established positions in clinical practice in North America and in Western European countries. In Japan, however, where radioisotope facilities are of limited availability, treatment plans for differentiated thyroid cancer differ considerably from those of America and Europe, and the associated clinical guidelines need modification before they can be adopted. In addition, although thyroid tumor is a common disease in endocrine practice, its management can differ even among specialists. Thus, a Japanese clinical guideline for the treatment of thyroid tumor was desired by many clinicians. As a combination of evidence-based and consensus-based guidelines for the treatment of thyroid tumor, this book offers alternatives to conventional approaches in the West. Ultimately, the authors hope the guideline will lead to the best possible treatment for patients all over the world in the not-distant future.
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  • Section I: Land of Opportunity -- The health care landscape -- Introduction -- Person-centered care -- Whole health -- Shared decision making -- Wagner care model -- Health care reform -- Medical necessity -- Integrated care -- Workforce changes -- Trauma-informed care -- DSM-5TM -- Ready to go -- Section II: Getting Started -- Assessment -- Stating the case -- Creating the solution -- Making it happen -- Understanding needs: the integrated summary -- Stating the case -- Creating the solution -- Making it happen -- Section III: On the Road -- Setting goals -- Stating the case -- Creating the solution -- Making it happen -- Focusing on change: identifying barriers and specifying objectives -- Stating the case -- Creating the solution -- Making it happen -- Interventions -- Stating the case -- Creating the solution -- Making it happen -- Journey's End: The Destination -- Evaluating the process -- Stating the case -- Creating the solution -- Making it happen.
  • This book provides essential knowledge for creating treatment plans for adult dental patients. Treatment planning strategies are presented to help with balancing the ideal with the practical, with emphasis placed on the central role of the patient -- whose needs should drive the treatment planning process. The focus is on planning of treatment, not on the comprehensive details of every treatment modality in dentistry. CD-ROM bound into book presents five cases of varying difficulty with interactive exercises that allow users to plan treatment. What's the Evidence? boxes link clinical decision-making and treatment planning strategies to current research. In Clinical Practice boxes highlight specific clinical situations faced by the general dentist. Review Questions and Suggested Projects, located at the end of each chapter, summarize and reinforce important concepts presented in the book. Key Terms and Glossary highlights the terms that are most important to the reader. Suggested Readings lists included at the end of most chapters provide supplemental resources.
  • "With the advent of computer technology and medical imaging, treatment planning in radiation oncology has evolved from a way of devising beam arrangements to a sophisticated process whereby imaging scanners are used to define target volume, simulators are used to outline treatment volume, and computers are used to select optimal beam arrangements for treatment. As such, this book is designed to provide a comprehensive discussion of the clinical, physical, and technical aspects of treatment planning. The intent of Treatment Planning in Radiation Oncology is to review these methodologies and present a contemporary version of the treatment planning process"--Provided by publisher.
  • "Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia."--Publisher's website.
  • Written to address conditions specifically associated with ethnic disparities in skin types, by Susan C. Taylor, Sonia Badreshia, Valerie D. Callender, Raechele Cochran Gathers and David A. Rodriguez , MD, helps you effectively diagnose and treat a wide-range of skin conditions found in non-white patients. Presented in an easy-to-use, templated format, this new reference encompasses medical dermatology and cosmetic procedures and provides you with evidence-based first and second line treatment options. Practical tips and other highlighted considerations minimize the risk of potential pitfalls. A dedicated section examines alternative therapies, some of which have cultural significance and may impact medical outcomes. An abundance of vivid color images and photos provide unmatched visual guidance for accurate diagnosis and treatment.
  • Anatomical overview of the central and peripheral nervous system -- Physiology of the nervous system -- Characterization of tremor -- Principal disorders associated with tremor -- Quantification of tremor -- Mechanisms of tremor -- Treatments.
  • From Darwin and Metchnikoff to Burnet and beyond / Cooper, E.L. -- General introduction to innate immunity: Dr. Jekyl/Mr. Hyde quality of the innate immune system / Zonker, K.S. -- The innate immune system of mammals and insects / Müller, U. ... [et al.] -- Pattern recognition receptors and their role in innate immunity: focus on microbial protein ligands / Areschoug, T., Gordon, S. -- Antimicrobial peptides in innate immune responses / Sorensen, O.E., Borregaard, N., Cole, A.M. -- Complement: an efficient sword of innate immunity / Rambach, G., Würzner, R., Speth, C. -- Antibacterial chemokines: actors in both innate and adaptive immunity / Eliasson, M., Egesten, A. -- The role of neutrophils and monocytes in innate immunity / Kantari, C., Pederzoli-Ribeil, M., Witko-Sarsat, V. -- Innate immune functions of the airway epithelium / Bartlett, J.A., Fischer, A.J., McCray, Jr, P.B. -- Oxidative innate immune defenses by Nox/Duox family NADPH oxidases / Rada, B., Leto, T.L. -- Aging and impairment of innate immunity / Nomellini, V., Gomez, C.R., Kovacs, E.J.
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  • This book covers topical issues in neurovascular surgery, and in particular the management of intracranial aneurysms, arteriovenous malformations, and cavernomas, current trends in cerebral revascularization, and new concepts in cerebrovascular imaging. The contents reflect the continuing developments in interventions in cerebrovascular disorders as a result of progress in neuroimaging, evolution of pathophysiological concepts, new clinical trials, and technological innovations. The chapters are all written by acknowledged experts from across the world, and comprise original papers presented at the 6th European Japanese Stroke Surgery Conference, held in June 2012 in Utrecht, The Netherlands. The book will be of value to all who are interested in the latest developments in the field and offers fascinating insights into varied perspectives and techniques.
  • Endoscopic Intra-Hematomal Evacuation of Intracerebral Hematomas - A Suitable Technique for Patients with Coagulopathies -- The Prediction of 30-Day Mortality and Functional Outcome in Spontaneous Intracerebral Hemorrhage with Secondary Ventricular Hemorrhage: A Score Comparison -- Characteristics of Carotid Plaque Findings on Ultrasonography and Black Blood Magnetic Resonance Imaging in Comparison with Pathological Findings -- Indication for Surgical Treatment of Carotid Arterial Stenosis in High-Risk Patients -- The Impact of Early Perfusion CT Measurement After Extracranial-Intracranial Bypass Surgery: Results of a Pilot Study -- Genetic and Clinical Characteristics of Moyamoya Disease in Europeans -- Effect of Mouth Opening on Bypass Function After Combined Revascularization for Moyamoya Disease -- Revascularisation Surgery and Long-Term Follow-up in Juvenile Moyamoya Syndrome: A Retrospective Analysis -- Tissue Fusion, a New Opportunity for Sutureless Bypass Surgery -- STA-MCA Bypass for the Treatment of Ischemic Stroke -- The New MRI Modalities "BPAS and VISTA" for the Diagnosis of VA Dissection -- Intracranial Stenting in Arterial Occlusive Disease -- A View on the Current and Future Therapy of Brain Aneurysms -- Surgical Treatment for Aneurysms in the Cavernous - Petrous Portion of the Internal Carotid Artery -- Aneurysms of the Posterior Cerebral Artery and Approach Selection in Their Microsurgical Treatment: Emphasis on the Approaches: SAHEA and SCTTA -- Neck Clipping of Paraclinoid Small Aneurysms -- Deferoxamine Reduces Early Brain Injury Following Subarachnoid Hemorrhage -- Does Magnetic Resonance Imaging Produce Further Benefit for Detecting a Bleeding Source in Subarachnoid Hemorrhage of Unknown Origin? -- Treatment of Experimental Cerebral Vasospasm by Protein Transduction of Heme Oxygenase 1 (HO-1) Conjugated to a Residue of 11 Arginines -- Training Models for Vascular Microneurosurgery -- How to Deal with Incompletely Treated AVMs: Experience of 67 Cases and Review of the Literature -- Clinical Relevance of Associated Aneurysms with Arteriovenous Malformations of the Posterior Fossa.
  • Part I. Molecular bases for stem and cancer cells proliferation -- An introduction to proliferation and migration of stem cells and cancer -- the role of cell adhesions, cell junctions and extracellular matrix in normal development and carcinogenesis -- The embryonic rest hypothesis of cancer development: 150 years later -- Are calcium channels more important than calcium influx for cell proliferation?- Role of calcium signaling in stem cells and cancer cells proliferation -- Formation and function of lipid droplets in inflammation and cancer -- The role of sphingolipids in modulating pluripotency of stem cells -- Part II. Signaling pathways to cancer cells fate -- Signaling pathways of cbl-b and its role on peripheral t cell tolerance -- Bh3-only proteins in cancer and apoptosis -- Signaling pathways of mta family proteins as regulators of cancer progression and metastasis -- Signalling pathways of [beta]-catenin/jnk on carcinogenesis -- The regulation of the jnk cascade and programmed cell death by nf- b: mechanisms and functions -- Part III. Uncontrolled physiology process guiding to cancer cells -- Migration, metastasis and more: the role of chemokines in the proliferation, spreading and metastasis of tumors -- Autophagy, cell death, and cancer -- The duality of stem cells: double edged sword in tumour evolution and treatment -- Glioblastoma stem cells and implications for chemoresistance -- The tumor microenvironment as a transient niche: a modulator of epigenetic states and stem cell functions -- Tumor-associated neutrophils (tans) -- Microrna control of apoptotic programs in cancer -- Part IV. Therapeutic strategies for anticancer treatment -- Markers of cancer stem cells and their functions -- Cancer cell dormancy: potential therapeutic targets to eradicate cancer cells within the niche -- Modulating apoptosis in cancer therapy with ultrasound and high intensity nanosecond electric pulses -- Targeting cell cycle for anticancer treatment and neuroprotection.
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  • Wear and osteolysis are still the most important potential problems in total hip and knee arthroplasty. Although technology in arthroplasty has been improved dramatically during the past decade, the clinical data relating to some implants reveal that many concerns remain. During the "Tribology Day" within the scientific programme of the 2013 EFORT Congress in Istanbul, the main topics included these concerns as well as the benefits of the materials most commonly used in total hip and knee arthroplasty. This book includes the presentations delivered on the day and covers a range of interesting issues regarding metal, ceramic, and polyethylene articulations. It provides information on the current concepts relating to tribology in total hip arthroplasty and offers a critical outlook on possible improvements in total knee arthroplasty.
  • This book is devoted solely to the tricuspid valve and its role in congenital heart disease. Tricuspid valve anomalies are part of the pathological spectrum in various congenital heart diseases, including Ebstein anomaly and tricuspid valve dysplasia, with different pathophysiology and clinical implications. This book covers all relevant aspects of such anomalies, including diagnosis, therapy, and follow-up. Further topics addressed include the way in which the tricuspid valve may become the 'systemic' valve in some congenital diseases, with important consequences, and the involvement of the tricuspid valve in the right-sided heart complications often seen in adults with congenital heart disease. All of the chapters are written by internationally recognized experts and are designed to deliver state of the art knowledge of practical value. This book will be an important addition to the library for surgeons, cardiologists, and other practitioners involved in the management of patients with congenital heart disease.
  • Historical Perspectives on Trigeminal Nerve Injuries -- Classification of Nerve Injuries -- Etiology and Prevention of Nerve Injuries -- Injection Injuries of the Trigeminal Nerve -- Third Molar Injuries of the Trigeminal Nerve -- Dental Implant-Related Injuries of the Trigeminal Nerve -- Nerve Repositioning Injuries of the Trigeminal Nerve -- Orthognathic Injuries of the Trigeminal Nerve -- Nerve Injury and Regeneration -- Clinical Evaluation of Nerve Injuries -- Imaging of the Trigeminal Nerve -- Nonsurgical Management of Trigeminal Nerve Injuries -- Surgical Management of Lingual Nerve Injuries -- Surgical Management of Inferior Alveolar Nerve Injuries -- Surgical Management of Facial Nerve Injuries -- Nerve Grafts and Conduits -- Complications of Trigeminal Nerve Repair -- Neurosensory Rehabilitation -- Outcomes of Trigeminal Nerve Repair -- Guidelines for Diagnosis and Treatment of Trigeminal Nerve Injuries.
  • Muscle chains / Philipp Richter: introduction -- Models of myofascial chains -- Physiology -- The craniosacral model -- The biomechanical model of John Martin Littlejohn : the mechanics of the spinal column -- Postural muscles, phasic muscles, and crossed syndrome (Vladimir Janda's contribution to myofacial treatment methods) -- Zink patterns -- Myofascial chains : a model -- Posture -- Diagnosis -- Therapy -- Trigger points and their treatment / Eric hebgen: Definition -- Classification of trigger points -- Pathophysiology of trigger points -- Diagnosis -- Trigger point therapy -- Trigger point-sustaining factores -- The facilitated segment -- The trigger points.
  • TRIM/RBCC proteins 2012
    Springer
    Genomics and evolution of the TRIM gene family / Germana Meroni -- The tripartite motif : structure and function / Lucia Micale ... [et al.] -- TRIM proteins as ring finger E3 ubiquitin ligases / Kazuhiro Ikeda and Satoshi Inoue -- PML nuclear bodies and other TRIM-defined subcellular compartments / Elizabeth C. Batty, Kirsten Jensen, and Paul S. Freemont -- TRIM involvement in transcriptional regulation / Florence Cammas ... [et al.] -- TRIM proteins in cancer / Valeria Cambiaghi ... [et al.] -- TRIM proteins and the innate immune response to viruses / Melvyn W. Yap and Jonathan P. Stoye -- The microtubule-associated C-I subfamily of TRIM proteins and the regulation of polarized cell responses / Timothy C. Cox -- MuRFS : specialized members of the TRIM/RBCC family with roles in the regulation of the trophic state of muscle and its metabolism / Olga Mayans and Siegfried Labeit -- Trim proteins in development / Francesca Petrera and Germana Meroni.
  • Triptans for migraine 2012
    Future Med
    Triptans for migraine / Hans-Christoph Diener & David W. Dodick -- Pathophysiology of migraine & triptan mechanism of action / Rashmi B. Halker & Bert B. Vargas -- Overview of oral triptans / Michail Vikelis & Alan M. Rapoport -- The non-orally administered triptans / Todd J. Schwedt -- Triptans for migraine in special populations : pediatric migraine / Paul Winner -- Migraine and triptan therapy in an aging population : weighing risks against benefits / Roger K. Cady & Kathleen Farmer -- Triptans for migraine in special populations : migraine during pregnancy and lactation / Sylvia Lucas -- Treatment recommendations & consensus guidelines / Hans-Christoph Diener & Stephen D. Silberstein -- Index.
  • Severe malaria, South African perspective / Lucille Blumberg -- Severe malaria: North American perspective / Monica E. Parise, and Linda S. Lewis -- Viruses in the intensive care unit (ICU), South African perspective / Guy A. Richards, Bunter Schleicher and Mervyn Mer -- Viral infections in ICU patients, North American perspective / David E. Greenburg, and Stephen B. Greenberg -- Tuberculosis in the intensive care unit, South African perspective / Charles Feldman -- Tuberculosis in the intensive care unit: the North American Perspective / Loren C. Denlinger, and Jeffrey Glassroth -- HIV in the ICU, South African perspective / Alan S. Karstaedt, L. Rhudo Mathivha, Christine L.N. Banage -- HIV infection and associated infections in the intensive care unit: perspectives from North America / Scott E. Evans and Andrew H. Limper -- African trypanosomiasis / Hayden T. White -- Parasitic infections in the ICU / John Frean -- Fungal infections in the ICU / Francois I. Venter and Ian Sanne -- Endemic mycosis, North American perspective / Chadi A. Hage, Kenneth S. Knox, George A. Sarosi -- Index.
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  • 2011 ClinicalKey
    Tropical Infectious Diseases: Principles, Pathogens and Practice, by Drs. Richard L. Guerrant, David H. Walker, and Peter F. Weller, delivers the expert, encyclopedic guidance you need to overcome the toughest clinical challenges in diagnosing and treating diseases caused by infectious agents from tropical regions. Sweeping updates to this 3rd edition include vaccines, SARS, hepatitis A-E, Crimean-Congo hemorrhagic fever virus, tick-borne encephalitis and Omsk hemorrhagic fever, human papilloma virus, and mucormycosis. New full-color images throughout allow you to more accurately view the clinical manifestations of each disease and better visualize the life cycles of infectious agents. And, full-text online access at www.expertconsult.com enables you to perform quick searches and rapidly locate and download images. Definitive, state-of-the-art coverage of pathophysiology as well as clinical management makes this the reference you'll want to consult - online and in print - whenever you are confronted with tropical infections, whether familiar or unfamiliar! Obtain complete and trustworthy advice from hundreds of the leading experts on tropical diseases worldwide, including cutting-edge summaries of pathophysiology and epidemiology as well as clinical management.
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  • Tropomyosin 2008
    Springer
    Introduction and historical perspective / Peter Gunning -- Structure and evolution of tropomyosin genes / Bernadette Vrhovski, Nadine Thézé, and Pierre Thiébaud -- Tropomyosin exons as models for alternative splicing / Clare Gooding and Christopher W.J. Smith -- Tropomyosin gene expression in vivo and in vitro / Galina Schevzov and Geraldine O'Neill -- Tropomyosin : function follows structure / Sarah E. Hitchcock-DeGregori -- Dimerization of tropomyosins / Mario Gimona -- Cooperative binding of tropomyosin to actin / Larry S. Tobacman -- Tropomyosin and the steric mechanism of muscle regulation / William Lehman and Roger Craig -- Role of tropomyosin in the regulation of contraction in smooth muscle / Steve Marston and M. El-Mezgueldi -- Tropomyosin as a regulator of cancer cell transformation / David M. Helfman ... [et al.] -- The role of tropomyosin in heart disease / David F. Wieczorek, Ganapathy Jagatheesan, and Sudarsan Rajan -- Tropomyosins in skeletal muscle diseases / Anthony J. Kee and Edna C. Hardeman -- Tropomyosins in human diseases : ulcerative colitis / Kiron M. Das and Manisha Bajpai -- Tropomyosin function in yeast / David Pruyne -- Isoform sorting of tropomyosins / Claire Martin and Peter Gunning -- Human tropomyosin isoforms in the regulation of cytoskeleton functions / Jim Jung ... [et al.] -- Tropomyosins regulate the impact of actin binding proteins on actin filaments / Uno Lindberg ... [et al.] -- Tropomyosin and ADF/cofilin as collaborators and competitors / Thomas B. Kuhn and James R. Bamburg -- Caldesmon and the regulation of cytoskeletal functions / C.L. Albert Wang -- Tropomyosins as discriminators of myosin function / E. Michael Ostap -- Tropomodulin/tropomyosin interactions regulate actin pointed end dynamics / Alla S. Kostyukova -- Emerging issues for tropomyosin structure, regulation, function, and pathology / Peter Gunning.
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    Ethnic symbols in conflicted times -- Eradicating a "Jewish gene": promises and pitfalls in the fight against Tay-Sachs disease -- Risky business in white America: gene therapy and other ventures in the treatment of cystic fibrosis -- A perilous lottery for the Black family: sickle cells, social justice, and the new therapeutic gamble -- Dreams amid diversity.
  • TRP channels 2011
    CRCnetBASE
    "Transient Receptor Potential (TRP) channels have gained a lot of popularity in recent years due to their involvement in a wide variety of cellular functions in many different systems. The purpose of this book is to provide detailed methods for the study of TRP channels. It includes expression and functional studies of TRP channels in heterologous systems as well as structural and functional studies of TRP channels. The author also explores various methods for detailed analysis of biophysical properties of TRP channels. In addition, the text covers high-throughput screening assays for TRP channels and offers novel and effective approaches to study endogenous TRP channel function in native systems"--Provided by publisher.
  • TRP channels in drug discovery v.1-2=, 2012
    Springer Protocols
    2nd ed., 2014 Springer Protocols
    V. 1. Introduction to TRPs : a quest for novel drug targets / Bernd Nilius -- TRP-mediated cytoskeletal reorganization : implications for disease and drug development / Chandan Goswami -- TRPA1 in drug discovery / Jun Chen, Steve McGaraughty, and Philip R. Kym -- Canonical transient receptor potential channel expression, regulation, and function in vascular and airway diseases / Brij B. Singh, Christina M. Pabelick, and Y.S. Prakash -- TRPM2 function and potential as a drug target / Barbara A. Miller -- Ca2+-activated monovalent cation-selective channels TRPM4 and TRPM5 / Barbara Colsoul ... [et al.] -- Emerging role of TRPM7 in the regulation of magnesium homeostasis / Vladimir Chubanov ... [et al.] -- TRPM8 channels as potential therapeutic targets for pain, analgesia, and thermoregulation / David D. McKemy -- TRPML channels in function, disease, and prospective therapies / David A. Zeevi -- TRPP signaling module : TRPP2/polycystin-1 and TRPP2/PKD1L1 / Alexis Hofherr -- TRPV1 as a polymodal sensor : potential to discover TRPV1 antagonists selective for specific activating modalities / Olivier Radresa ... [et al.] -- Nociceptive and nonnociceptive roles of TRPV3 and its "druggability" / Sungjae Yoo and Sun Wook Hwang -- TRPV4 and drug discovery / Fabien Vincent and Matthew A.J. Duncton -- TRP expression and function in the lung airways / Alexander Dietrich and Thomas Gudermann -- Hypoxia-dependent TRP channel function in pulmonary arterial smooth muscle cells / Beate Fuchs ... [et al.] -- Endotoxin-induced airway inflammation and asthma models / Zsuzsanna Helyes and Zsofia Hajna -- Enhanced cough, animal models / Raffaele Gatti ... [et al.] -- Capsaicin inhalation test in man / Eva Millqvist -- TRP channels in the genitourinary tract / Ana Charrua and Francisco Cruz -- Animal models of cystitis / Celia D. Cruz and Antonio Avelino -- Overactive bladder models / Roberto Soler ... [et al.] V. 2. TRPs to cardiovascular disease / José C. González-Cobos, Xuexin Zhang, Rajender K. Motiani, Kelly E. Harmon, and Mohamed Trebak -- Anemic zebrafish models of cardiomyopathy / Xiaojing Sun and Xiaolei Xu -- Methods to study the effects of TRP channel drugs on vascular endothelial cell function / Yan Ma, Yung-Wui Tjong, and Xiaoqiang Yao -- Atherosclerosis models with cell-mediated calcification / Beili Zhu -- Models of hypertension and blood pressure recording / Luciana Aparecida Campos and Ovidiu Constantin Baltatu -- Balloon injury in rats as a model for studying TRP channel contribution to vascular smooth muscle remodeling / Wei Zhang and Mohamed Trebak -- TRP channels in the brain / Antonio Reboreda -- Investigation of the possible role of TRP channels in schizophrenia / Loris A. Chahl -- Investigating diseases of dopaminergic neurons and melanocytes using zebrafish / Amanda Decker and Robert Cornell -- A practical guide to evaluating anxiety-related behavior in rodents / Caitlin J. Riebe and Carsten T. Wotjak -- Rodent models of conditioned fear: behavioral measures of fear and memory / Jennifer L. McGuire, Jennifer L. Coyner, and Luke R. Johnson -- Chick anxiety-depression screening model / Stephen W. White and Kenneth J. Sufka -- A clinically relevant thromboembolic stroke model in the aged rat / Ryan C. Turner, Alisa S. Elliott, Jason D. Huber, and Charles L. Rosen -- Use of cell-stretch system to examine the characteristics of mechanosensor channels: axonal growth/neuroregeneration studies / Koji Shibasaki -- Methods in neuronal growth cone biology / Robert J. Gasperini and Lisa Foa -- Transient receptor potential channels and pruritus / Heike Benecke, Janine Wäring, Tobias Lotts, and Sonja Ständer -- Skin sensitivity studies / Laurent Misery -- Hair follicle culture / Michael P. Philpott -- Animal models for type 1 diabetes / Anish Suri and Matteo Levisetti -- Type 2 diabetes models / Dorte X. Gram -- Using diet to induce metabolic disease in rodents / Angela M. Gajda, Michael A. Pellizzon, and Matthew R. Ricci -- Rodent models to evaluate anti-obesity drugs / Sharon C. Cheetham and Helen C. Jackson -- Experimental colitis models / Patrick A. Hughes, Stuart M. Brierley, Joel Castro, Andrea M. Harrington, and L. Ashley Blackshaw -- Tumor xenograft models to study the role of TRP channels in Tumorigenesis / V'yacheslav Lehen'kyi, Sergii Khalimonchyk, Albin Pourtier, Maylis Raphaël, and Natalia Prevarskaya -- Methods to study thermonociception in rodents / Kata Bölcskei -- Methods for the assessment of heat perception in humans / Michael F. Crutchlow and Joel D. Greenspan -- Collagen antibody-induced arthritis: a disease-relevant model for studies of persistent joint pain / Katalin Sandor, Kutty Selva Nandakumar, Rikard Holmdahl, and Camilla I. Svensson -- Animal models of muscular dystrophy / Yuko Iwata and Shigeo Wakabayashi -- Concluding remarks.
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  • Introduction: In the Aftermath of the So-Called Memory Wars / Robert F. Belli -- The Cognitive Neuroscience of True and False Memories / Marcia K. Johnson, Carol L. Raye, Karen J. Mitchell, and Elizabeth Ankudowich -- Towards a Cognitive and Neurobiological Model of Motivated Forgetting / Michael C. Anderson and Ean Huddleston -- Searching for Repressed Memory / Richard J. McNally -- A Theoretical Framework for Understanding Recovered Memory Experiences / Chris R. Brewin -- Cognitive Underpinnings of Recovered Memories of Childhood Abuse / Elke Geraerts -- Motivated Forgetting and Misremembering: Perspectives from Betrayal Trauma Theory / Anne P. DePrince, Laura S. Brown, Ross R. Cheit, Jennifer J. Freyd, Steven N. Gold, Kathy Pezdek, and Kathryn Quina -- Epilogue: Continuing Points of Contention on the Recovered Memory Debate / Robert F. Belli.
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  • Cell Biology for Immune Evasion: Organizing Antigenic Variation, Surfaces, Trafficking, and Cellular Structures in Trypanosoma brucei / Ka Fai Leung, Paul T. Manna, Cordula Boehm, Luke Maishman and Mark C. Field -- The Biology of Tsetse-Trypanosome Interactions / Guy Caljon, Linda De Vooght and Jan Van Den Abbeele -- Withstanding the Challenges of Host Immunity: Antigenic Variation and the Trypanosome Surface Coat / James Peter John Hall and Lindsey Plenderleith -- Bridging Innate and Adaptive Immunity in African Trypanosomiasis / John M. Mansfield, Donna M. Paulnock and Gina M. Hedberg -- Adaptive Immunity and Trypanosomiasis-Driven B-Cell Destruction / Stefan Magez and Magdalena Radwanska -- Normal Human Serum Lysis of Non-human Trypanosomes and Resistance of T. b. rhodesiense and T. b. gambiense / Paul Capewell, Caroline Clucas, William Weir, Nicola Veitch and Annette MacLeod -- Proteomics and African Trypanosomes: Shedding New Light on Host-Vector-Parasite Interactions and Impact on Control Methods / Philippe Holzmuller, Pascal Grébaut and Anne Geiger -- Diagnosis of African Trypanosomiasis / Philippe Büscher -- Progress Towards New Treatments for Human African Trypanosomiasis / Jose A. Garcia-Salcedo, Jane C. Munday, Juan D. Unciti-Broceta and Harry P. de Koning -- Animal African Trypanosomosis in Sub-Saharan Africa and Beyond African Borders / Boniface Namangala and Steven Odongo -- Trypanosoma (Duttonella) vivax and Typanosomosis in Latin America: Secadera/Huequera/Cacho Hueco / Mary Isabel Gonzatti, Bernardo González-Baradat, Pedro M. Aso and Armando Reyna-Bello.
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  • Part I. Rationale and objectives -- Chapter 1. What, why, where and how? -- Chapter 2. Survey goal, objectives and indicators -- Part II. Design and methods -- Chapter 3. Protocol development and standard operating procedures -- Chapter 4. Case definitions and screening strategies -- Chapter 5. Sampling design -- Chapter 6. Interviews, data collection tools and informed consent -- Chapter 7. Chest radiography -- Chapter 8. Bacteriology -- Chapter 9. Repeat surveys -- Chapter 10. Ethical considerations -- Chapter 11. TB treatment, HIV testing and other critical interventions -- Chapter 12. Budgeting and financing -- Part III. Management, organization, logistics and field work -- Chapter 13. Survey organization and training -- Chapter 14. Field operations -- Chapter 15. Documents and data management -- Part IV. Analysis and reporting -- Chapter 16. Analysis and reporting.
  • TB prevention / Jean-Pierre Zellweger -- Optimal diagnosis : how early and improved diagnosis can help prevent TB transmission / Sandra Vivian Kik, Zhi Zhen Qin & Madhukar Pai -- Current transmission prevention methods : vaccination / Rosalind Rowland & Helen McShane -- Current transmission prevention methods : reducing disease spread from infected individuals / Gregory J. Fox, Guy B. Marks & Warwick J. Britton -- Special concerns for at-risk populations / Ivan Solovic & Vladimir Littva -- Prevention of TB in the presence of coinfection and comorbid conditions / Dina Nair & Soumya Swaminathan -- Public health, TB, immigration and travel challenge / Jean-Pierre Zellweger -- Ask the experts : managing TB in clinical practice and the impact on transmission / Jean-Pierre Zellweger -- Multiple choice questions : answers.
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    The global tuberculosis epidemic : scale, dynamics, and prospects for control / Christopher Dye and Philippe Glaziou -- The epidemiology of tuberculosis / Megan Murray -- Pathogenesis of tuberculosis : new insights / Nicholas A. Be, William R. Bishai, and Sanjay K. Jain -- Diagnosis of pulmonary and extrapulmonary tuberculosis / Phung K. Lam, Antonino Catanzaro, and Sharon Perry -- Treatment of tuberculosis / Philip C. Hopewell -- Tuberculosis/HIV coinfection : epidemiology, clinical aspects, and programmatic interventions / Alasdair Reid, Haileyesus Getahun, and Enrico Girardi -- Diagnosis and treatment of drug-resistant tuberculosis / Kwonjune Seung and Michael L. Rich -- Achieving higher case detection and cure rates : national programs and beyond / Knut Lönnroth ... [et al.] -- Antituberculosis drug resistance in the world : the latest information / Abigail Wright and Matteo Zignol -- Programmatic management of HIV-associated tuberculosis / Anthony D. Harries and Paul P. Nunn -- WHO's stop TB strategy : progress and prospects / Mukund Uplekar, Diana Weil, and Mario C. Raviglione -- New diagnostics for tuberculosis : status of development / Mark D. Perkins and Richard J. O'Brien -- New drugs for tuberculosis / Ann Ginsberg and Melvin Spigelman -- The future of tuberculosis vaccinology / Jelle Thole, Ruth Griffin, and Douglas Young.
  • Ptie 1. Contexte général des tumeurs rares -- ptie 2. Formes rares de tumeurs ubiquitaires et contextes rares de cancers -- ptie 3. Autres tumeurs rares par site.
  • Effect of Chemotherapy on the Tumor Microenvironment and Anti-tumor Immunity / Tarek M. Meniawy, Anna K. Nowak and Richard A. Lake -- Hyperthermia, the Tumor Microenvironment and Immunity / Stuart K. Calderwood -- Radiofrequency Ablation in Cancer Therapy: Tuning in to in situ Tumor Vaccines / Stefan Nierkens, Martijn H. den Brok, Theo J. Ruers and Gosse J. Adema -- High Intensity Focused Ultrasound (HIFU) Ablation / Feng Wu -- The Interrelationship Between Cryoablation, the Immune Response and the Tumor Microenvironment: Stimulatory and Suppressive Effects / Michael S. Sabel -- In situ Tumor Ablation with Radiation Therapy: Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / William H. McBride and Dörthe Schaue -- Tumor-Localized Insult Delivered by Photodynamic Therapy and the Breakdown of Tumor Immunotolerance / Mladen Korbelik -- In situ Ablation of Solid Tumors by Electric Forces and Its Effect on the Tumor Microenvironment and Anti-tumor Immunity / Yona Keisari and Rafi Korenstein.
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  • v.2, 2014 Springer
  • Analysis of multidirectional immunological responses at the tumor site allows forming a new concept of The Tumor Immunoenvironment, which is introduced and discussed in the present book with a particular focus on the role of immune cells in controlling the tumor microenvironment at different stages of cancer development. The main goal of this publication is to provide an overview of the current knowledge on the complex and unique role of the immune system, tumor-associated inflammation and tumor-mediated immunomodulation in cancer progression in a way that allows understanding the logistics of cellular and molecular interactions in the tumor lesions.
  • Tumor microenvironment v. 1-, 2008-
    Springer
  • This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe the influence of infiltrating cells of the immune system on tumor growth.
  • The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.
  • Perspectives on the history and evolution of tumor models -- Murine L1210 and P388 leukemias -- Transplantable syngeneic rodent tumors: solid tumors in mice -- B16 murine melanoma: historical perspective on the development of a solid tumor model -- Human tumor xenograft efficacy models -- Imaging the steps of metastasis at the macro and cellular level with fluorescent proteins in real time -- Patient-derived tumor models and explants -- The pediatric preclinical testing program -- Imaging efficacy in tumor models -- Mammary cancer in rats -- Animal models of melanoma -- Experimental animal models for investigating renal cell carcinoma pathogenesis and preclinical therapeutic approaches -- Animal models of mesothelioma -- The use of mouse models to study leukemia/lymphoma and assess therapeutic approaches -- Spontaneous companion animal (pet) cancers -- Genetically engineered mouse models of pancreatic ductal adenocarcinoma -- Transgenic adenocarcinoma of the mouse prostate: a validated model for the identification and characterization of molecular targets and the evaluation of therapeutic agents -- The utility of transgenic mouse models for cancer prevention research -- Models for evaluation of targeted therapies of invasive and metastatic disease -- Animal models of toxicities caused by anti-neoplastic therapy -- Bone marrow as a critical normal tissue that limits drug dose/exposure in preclinical models and the clinic -- Anesthetic considerations for the study of murine tumor models -- Preclinical tumor response end points -- Tumor cell survival -- Apoptosis in vivo -- Transparent window models and intravital microscopy: imaging gene expression, physiological function and therapeutic effects in tumors.
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  • I. Investigations -- Neurophysiology / Allen E. Waziri, Derek A. Taggard and Vincent C. Traynelis -- Neuroradiology and Ultrasound / David G. Hughes and Roger A. Chisholm -- Neuropathology / Cheng-Mei Shaw and Ellsworth C. Alvord -- II. Perioperative Care -- Neuroanesthesia / Maryke A. Kraayenbrink and Gregory R. McAnulty -- Neurosurgical Intensive Care / Tessa L. Whitton and Arthur M. Lam -- III. Techniques -- Neuroendoscopy / Jonathan Punt -- Principles and Practice of Image-guided Neurosurgery / Kristian Aquilina, Philip Edwards and Anthony Strong -- Stereotactic Radiosurgery / Andras A. Kemeny, Matthias W. R. Radatz and Jeremy G. Rowe -- IV. Tumors -- Low-grade Gliomasin Adults / Henry Marsh -- Neurosurgical Management of High-grade Gliomas / Robert C. Rostomily, Alexander M. Spence and Daniel L. Silbergeld -- Sellar and Parasellar Tumors / Richard J. Stacey and Michael P. Powell -- Meningiomas / James J. Evans, Joung H. Lee, John Suh and Mladen Golubic -- Intraventricular and Pineal Region Tumors / Sandeep Kunwar, G. Evren Keles and Mitchell S. Berger -- Cerebello-pontine Angle Tumors / Peter C. Whitfield and David G. Hardy -- Skull Base Tumors / Richard S. C. Kerr and Christopher A. Milford -- Tumors: Cerebral Metastases and Lymphoma / Sepideh Amin-Hanjani and Griffith R. Harsh -- Pediatric Neuro-oncology / Kevin L. Stevenson, J. Russell Geyer and Richard G. Ellenbogen -- Management of Spinal Tumors / Karl F. Kothbauer, George I. Jallo and Fred J. Epstein -- Management of Extradural Spinal Tumors / David A. Lundin, Charlie Kuntz and Christopher I. Shaffrey.
  • Lifestyle and Medical Approaches to Cancer Prevention / Peter Greenwald, p. 1-15 -- Application of Genetics to the Prevention of Colorectal Cancer / John Hopper, p. 17-33 -- Genetics and Prevention of Oesophageal Adenocarcinoma / Rebecca Fitzgerald, p. 35-46 -- Preclinical Models Relevant to Diet, Exercise, and Cancer Risk R. James Barnard and William Aronson, p. 47-62 -- Individualizing Interventions for Cancer Prevention / Michael Pollak, p. 63-70 -- Can Animal Models Help Us Select Specific Compounds for Cancer Prevention Trials? / Ernest Hawk, Asad Umar, Ronald Lubet, Levy Kopelovich and Jaye Viner, p. 71-88 -- Problems with Using Biomarkers as Surrogate End Points for Cancer: A Cautionary Tale / Arthur Schatzkin, p. 89-98 -- Can a Marker Be a Surrogate for Development of Cancer, and Would We Know It if It Exists? / William Armstrong, Thomas Taylor and Frank Meyskens, p. 99-112 -- How Should We Move the Field of Chemopreventive Agent Development Forward in a Productive Manner? / Frank Meyskens and Eva Szabo, p. 113-124 -- The Problems with Risk Selection; Scientific and Psychosocial Aspects / Anne-Renée Hartman, p. 125-144 -- Chemoprevention of Lung Cancer / Stéphane Vignot, Jean-Philippe Spano, Sylvie Lantuejoul, Fabrice André, Thierry Le Chevalier and Jean-Charles Soria, p. 145-165 -- Anti-nicotine Vaccination: Where Are We? / T. Cerny, p. 167-175 -- Primary Prevention of Colorectal Cancer: Lifestyle, Nutrition, Exercise / María Martínez, p. 177-211 -- Chemoprevention of Colorectal Cancer: Ready for Routine Use? / Nadir Arber and Bernard Levin, p. 213-230 -- Screening of Colorectal Cancer: Progress and Problems Sidney Winawer, p. 231-244 -- The Role of Endogenous Hormones in the Etiology and Prevention of Breast Cancer: The Epidemiological Evidence / Paola Muti, p. 245-256 -- Innovative Agents in Cancer Prevention / Margaret Manson, Peter Farmer, Andreas Gescher and William Steward, p. 257-275 -- The IARC Commitment to Cancer Prevention: The Example of Papillomavirus and Cervical Cancer / Silvia Franceschi, p. 277-297 -- Health Economics in the Genomic Age / Thomas Szucs, p. 299-313 -- Screening for Cancer: Are Resources Being Used Wisely? / Robert Kaplan, p. 315-334.
  • Tumor suppressor genes
    Springer Protocols
    v. 2 Springer Protocols
    v. 1 Pathways and isolation strategies -- v. 2 Regulation, function, and medicinal application.
  • During the last 20 years, it has become increasingly clear that the tumor micro-environment, the tumor stroma with its cellular end extracellular components, plays an crucial role in regulating tumor growth and progression. This book on 'Tumor-associated fibroblasts and their matrix' as part of the series on "Tumor-Microenvironment" is the first comprehensive discussion of these two main players of the tumor microenvironment. The best experts in this new area of tumor research and therapy review the role of these major components in the tumor stroma in the process of tumor developmen.
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  • Cesar A. Moran and Saul Suster are internationally recognized experts in pulmonary pathology who present a coherent and consistent approach to interpretation and diagnosis. Through more than 900 stunning photographs and a consistent, user-friendly format, this resource provides quality guidance on the diagnostic problems you face in everyday practice. You'll get a host of innovative, practice-oriented features unavailable in any other text that streamline and facilitate diagnostic decision-making. Written by practitioners for practitioners, this visual resource is designed for quick and easy use.
  • Includes bibliographical references and index. Introduction -- Bone-forming tumors -- Cartilage-forming tumors -- Giant cell tumor -- Round cell tumor -- Fibrous tumors -- Fibrohistiocytic tumors -- Vascular Tumors -- Adamantinoma -- Notochordal tumors -- Leiomyosarcoma -- Adipocytic tumors -- Neurogenic tumors -- Phosphaturic mesenchymal tumor -- Metastatic carcinoma involving bone -- Tumor-like lesions and other conditions that simulate primary tumors.
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  • Pt. 1. Astrocytomas : diagnosis and biomarkers -- pt. 2. Astrocytomas : therapy -- pt. 3. Astrocytomas : prognosis -- pt. 4. Hemangioblastoma -- pt. 5. Ganglioglioma -- pt. 6. Spinal Tumors (Part 1) -- pt. 7. Meningiomas and Schwannomas -- pt. 8. Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma.
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  • Adding to a vitally important cycle of publications covering the latest research developments in our understanding of neoplasms affecting the human central nervous system, this edition focuses on numerous aspects of pineal, pituitary, and spinal tumors. As with the previous volumes in the series, this latest work addresses a central imperative in cancer research--the need to standardize classifications, written definitions and investigative guidelines in order to achieve a measure of shared objectivity among academics engaged in one of the most important medical endeavors of our era. It brings together the very latest work by oncologists, neurosurgeons, physicians, research scientists, and pathologists, providing the medical community with a wealth of data and results that, taken together, will advance the cause of cancer research. The volume synthesizes work on diagnosis, drug development, and therapeutic approaches that are typically scattered in a variety of journals and books. It features promising recent work in applying molecular genetics to clinical practice and evidence-based therapy, covering molecular profiling of tumors as well as a number of surgical treatments such as resection and radiosurgery. Together with its counterpart publications, it represents a much-needed central resource that will inform and guide future research efforts.
  • Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.
  • Classification/Diagnosis of Brain Tumors Using Discriminant Function Analysis -- Neuronal Differentiation in the Adult Brain: CDK6 as the Molecular Regulator -- Prolactinomas: Role of VEGF, FGF-2 and CD31 -- Human Brain Tumor Growth: Role of Aquaporins -- Molecular and Functional Characterization of Human Adipocytes -- Inhibition of Neuroblastoma Progression by Targeting Lymphangiogenesis: Role of an Endogenous Soluble Splice-Variant of VEGFR-2 -- Hyperinsulinemia Tends to Induce Growth Without Growth Hormone in Children with Brain Tumors After Neurosurgery -- Childhood Brain Tumours: Proton Beam Therapy -- Pathogenesis of Medulloblastoma: Role of Molecular Genetic Alterations -- Medulloblastomas: Survival Differences Between Children and Adults -- Survivors of Childhood Cancer: Risk of Glioma and Meningioma Following Radiotherapy -- Survivors of Childhood Cancer: Risk of New Primary Neoplasms of the CNS -- Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics -- Atlas-Based Segmentation of Tumor-Bearing Brain Images -- Nonthermal Irreversible Electroporation as a Focal Ablation Treatment for Brain Cancer -- The Role of Whole Brain Radiation Therapy for Metastatic Brain Tumors -- Craniotomy for Intracranial Tumors: Role of Postoperative Hematoma in Surgical Mortality -- Pituitary Adenomas: Treatment Using the Endonasal Approach -- Intracranial Tumors: Treatment with Endoscopic Neurosurgery -- Incidence of Recraniotomy for Postoperative Infections After Surgery for Intracranial Tumors -- Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function -- Treatment of Brain Tumors: Electrochemotherapy -- Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection -- The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance -- Drugs for Primary Brain Tumors: An Update -- Neurosurgical Treatment for Brain Metastases: Clinical Features, Operative Strategies, Recurrence and Survival -- Image-Guided Radiosurgery for Hypothalamic Hamartomas -- Image-Guided Stereotactic Radiosurgery for Spinal Pathology -- Image-Guided Stereotactic Radiosurgery for Optic Nerve Sheath Meningiomas -- Brain Metastases: The Application of Stereotactic Radiosurgery and Technological Advances -- Treatment of Chordomas by Stereotactic Radiosurgery with a Linear Accelerator: Comparison with Other Modes.
  • Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.
  • v. 2, 2012 Springer
  • v. 4 Springer
  • Pt. 1. Astrocytomas : diagnosis and biomarkers -- pt. 2. Astrocytomas : therapy -- pt. 3. Astrocytomas : prognosis -- pt. 4. Hemangioblastoma -- pt. 5. Ganglioglioma.
  • This volume contains information on the diagnosis, therapy, and prognosis of spinal tumors. Various aspects of different major types of spinal tumors (astrocytomas, ependymomas, and oligodendroglioma) are discussed. Insights into the understanding of molecular pathways involved in tumor biology are explained. Classification of intradural spinal tumors, including the percentages of each of the three major types, is detailed. Symptoms, radiological features, and clinicopathological parameters of spinal cord tumors are explained. Diagnosis, outcome, and prognosis of primary spinal cord and oligodendroglioma are discussed. Diagnosis of some other spinal tumors (e.g., pilomyxoid and chordomas) is also explained. The useful role of neuroimaging in diagnosing spinal teratoid/rhabdoid and gangliogliomas is included. A wide variety of treatments of a number of spinal cord tumor types are presented in detail. Therapies discussed include chemotherapy, surgery, radiosurgery, stereotactic radiosurgery, Cyberknife stereotactic radiotherapy, standard radiation alone, and rhenium-186 intracavity radiation. Also are duiscussed embolozation and spondylectomy. The usefulness of transplantation of human embryonic stem cells-derived oligodendrocyte progenitors and motoneuron progenitors in the repair of injured spinal cord is emphasized. Symptoms of the advent of spinal tumors are pointed out. Introduction to new technologies and their applications to spinal cord tumor diagnosis, treatment, and therapy assessment are explained
  • This volume offers in-depth discussion of two types of brain tumors - meningioma and schwannoma - covering diagnosis, therapy, and prognosis. It covers molecular genetics, and such therapeutic methods as neurosurgery, gamma knife radiosurgery, and adjuvant radiation
  • With tens of thousands of new CNS tumor cases each year in the US alone, this series of publications is a valuable aid to the diagnosis and treatment of these problematic neoplasms. Now, the eighth in the set returns to the topic of brain tumors, dealing with seven distinct types: astrocytoma, medulloblastoma, retinoblastoma, chordoma, craniopharyngioma, oligodendroglioma, and ependymoma. After updating the classification of medulloblastoma the volume provides an overview of ependymoma as well as describing the delineation of prognosis based on the genetic aberrations of the latter patients. The material offers key insights into the molecular pathways involved in tumor biology, such as the role of E-cadherin gene instability, carbonic anhydrase II, urokinase plasminogen activator, and Wnt signaling in meningioma. Contributors explain the genetic and clinical features associated with recurring meningioma, including the role played by erythropoietin receptor, and examine the way in which OTX2 transcription factor functions as an oncogene in medulloblastoma. With much more besides, including discussion of the molecular mechanisms that result in resistance to chemotherapy in medulloblastoma, this volume and its companions have a positive role to play in inspiring a new generation of researchers to design new drugs that are better targetedand thus more effective.
  • The ninth volume in this essential series discusses key advances in our understanding of neoplasms in the human central nervous system. This publication deals with various aspects of nine separate types of brain tumors. With 70 contributors from 17 nations, this edition offers an unrivalled thoroughness and breadth of coverage that includes the very latest research results on the following tumor types: astrocytoma, lymphoma, supratentorial and glioneuronal tumors, gangliogliomas, neuroblastoma in adults, hemangioma, and ependymoma.The content introduces new technologies and their applications
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    Normal pancreas -- Classification of pancreatic tumors -- Staging -- Serous cystic neoplasms -- Mucinous cystic neoplasms -- Intraductal neoplasms -- Ductal adenocarcinoma -- Adenocarcinoma variants -- Acinar neoplasms -- Pancreatoblastoma -- Solid-pseudopapillary neoplasms -- Endocrine neoplasms -- Nonepithelial and miscellaneous neoplasms -- Secondary neoplasms -- Non-neoplastic tumors and tumor-like lesions -- Dissection and reporting of pancreatic resection specimens -- Diagnostic evaluation of pancreatic neoplasms.
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    Specimen evaluation -- Nonmalignant fibroblastic and myofibroblastic tumors and tumor-like lesions -- Fibroblastic/myofibroblastic neoplasms with variable biologic potential -- Lipomatous tumors -- Smooth muscle tumors -- Tumors with skeletal muscle differentiation -- Vascular tumors -- Soft tissue tumors with cartilaginous or osseous differentiation -- Soft tissue tumors with epithelial differentiation -- Miscellaneous translocation sarcomas -- Miscellaneous tumors -- Cytopathology of soft tissue tumors and tumor-like lesions.
  • Tumors of the spine 2008
    ClinicalKey
    Achieve optimal outcomes for your patients with this new multimedia reference. Organized by tumor then by region, this resource details diagnostic and therapeutic options for primary and malignant spinal tumors. Over 25 key procedures--including minimally invasive surgery--are presented in a concise, stepwise fashion, putting the key information you need right at your fingertips! Over 600 illustrations round out this exhaustive new reference. Keep up to date on the latest advances in diagnosis and therapy with discussions of the latest surgical techniques, including minimally invasive spine surgery. Chapter templating helps you understand the entire procedure as well as key aspects, pearls and pitfalls, before heading into the OR. Have all the information you need to make a diagnosis and plan patient management with oversized, full color clinical photos and line drawings that illustrate key diagnoses and surgical procedures.
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    Testicular tumors : general considerations -- Germ cell tumors : histogenetic considerations and intratubular germ cell neoplasia -- Germ cell tumors : seminomas -- Nonseminomatous germ cell tumors -- Mixed germ cell tumors, regressed germ cell tumors, and germ cell-sex -- Sex cord-stromal tumors -- Miscellaneous primary tumors of the testis, adnexa, and spermatic cord; hematopoietic tumors; and secondary tumors -- Tumor-like lesions.
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  • Essential cardiac anatomy and physiology as it relates to the electrocardiogram -- Electrocardiographic waveforms -- Cardiac vectors and lead systems -- Derivation of the normal electrocardiogram -- Electrical axis -- Intraventricular conduction delays: the hemiblocks -- Intraventricular conduction delays: the bundle branch blocks -- Chamber enlargement -- Myocardial infarction -- Ischemia and anginal syndromes -- The electrocardiogram and the clinical evaluation of chest pain -- The advanced cardiac life support provider and therapeutic interventions in acute myocardial infarction -- Miscellaneous conditions -- Case presentations.
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    Foundation of the Society -- The Society established and Manson's presidency, 1907-9 -- Ross's presidency: 'from a very tender plant to a very vigorous tree', 1909-11 -- The Pre-war years (1911-14) and the Royal Society of Medicine's attempt to absorb the STMH -- The Society during the Great War (1914-18) -- Early inter-war years (1919-20) -- The Society becomes Royal -- The 1920s : consolidation of the Society, but still no permanent base, and an unfortunate episode involving the Colonial Office -- George Carmichael Low's presidency and removal to Manson House, 1929-33 -- The Mid-1930s: the Society safely installed in its own house -- The Pre-World War II years -- The Society during World War II (1939-45), and the future of clinical tropical medicine -- The Early post-war years, 1946-50 -- Completion of the Society's first half-century in 1957 -- Epilogue to the Society's first half-century, 1907-57.
  • First-trimester detection of fetal anomalies -- Fetal aneuploidies -- Routine fetal anomaly scan -- Amniotic fluid -- Disorders of the placenta : localization and placental attachment disorders -- Prenatal diagnosis of fetal infections -- Fetal anomalies: the geneticist's approach -- Diagnosis of hydrops and multiple malformation syndromes -- Assessment of twin gestation -- Fetal growth -- Cranial abnormalities -- Diagnosis of spina bifida and other dysraphisms in the fetus -- Abnormalities of the face and neck -- Cardiac abnormalities and arrhythmias -- Pulmonary abnormalities -- Skeletal abnormalities -- Abdominal and abdominal wall abnormalities -- Urinary tract abnormalities -- Haematological disorders -- Fetal tumours -- Fetal magnetic resonance imaging -- Fetal pathology.
  • Two-dimensional electrophoresis : an overview / Richard Smith -- Solubilization of proteins in 2DE : an outline / Thierry Rabilloud -- Selection of pH ranges in 2DE / Mireille Starita-Geribaldi -- Difficult proteins / Ben Herbert and Elizabeth Harry -- Organelle proteomics / Matthias Plöscher ... [et al.] -- Applications of chemical tagging approaches in combination with 2DE and mass spectrometry / Alexander Leitner and Wolfgang Lindner -- Immunoblotting 2DE membranes / Brian McDonagh -- Troubleshooting image analysis in 2DE / Bettina Levänen and Åsa M. Wheelock -- Analysis of bacterial proteins by 2DE / Philip Cash and Evelyn Argo -- Proteomic analysis of Caenorhabditis elegans / Pan-Young Jeong ...[et al.] -- Protein extraction for 2DE / Claus Zabel and Joachim Klose -- Analysis of proteins from marine molluscs / Suze Chora, Maria João Bebianno, and Michèle Roméo -- Preparation and analysis of plastid proteomes by 2DE / Anne von Zychlinski and Wilhelm Gruissem -- High resolution 2DE / Katrin Marcus ...[et al.] -- Blue native-gel electrophoresis proteomics / Kelly Andringa, Adrienne King, and Shannon Bailey -- 2DE for proteome analysis of human metaphase chromosomes / Kiichi Fukui and Susumu Uchiyama -- Microsomal proteomics / Diana M. Wong and Khosrow Adeli -- Prefractionation using microscale solution IEF / Won-A Joo and David Speicher -- Diagonal electrophoresis for detection of protein disulphide bridges / Brian McDonagh -- High-resolution large-gel 2DE / Claus Zabel and Joachim Klose -- Silver staining of proteins in 2DE gels / Cécile Lelong ...[et al.] -- Detection of 4-hydroxy-2-nonenal- and 3-nitrotyrosine-modified proteins using a proteomics approach / Rukhsana Sultana, Tanea Reed, and D. Allan Butterfield -- Proteomic detection of oxidized and reduced thiol proteins in cultured cells / Sarah L. Cuddihy ...[et al.] -- Detection of ubiquitination in 2DE / Brian McDonagh -- Phosphoroproteome analysis by in-gel isoelectric focusing and tandem mass spectrometry / Sarka Beranova-Georgianni, Dominic M. Desiderio, and Francesco Giorgianni -- Detection of protein glutathionylation / Elisabetta Gianazza, Ivano Eberini, and Pietro Ghezzi -- Activity-based protein profiling of protein tyrosine phosphatases / Chad Walls, Bo Zhou, and Zhong-Yin Zhang -- Active protease mapping in 2DE gels / Zhenjun Zhao and Pamela J. Russell -- Two-dimensional difference gel electrophoresis / Gert Van den Bergh -- Protein expression profiling / Brian P. Bradley, Bose Kalampanayil, and Michael C. O'Neill -- C-terminal sequence analysis of 2DE-separated proteins / Bart Samyn, Kjell Sergeant, and Jozef Van Beeumen -- Shotgun protein analysis by liquid chromatography-tandem mass spectrometry / Kazuishi Kubota, Toshiyuki Kosaka, and Kimihisa Ichikawa --De novo sequence analysis of N-terminal sulfonated peptides after in-gel guanidination / Kjell Sergeant, Jozef Van Beeumen, and Bart Samyn -- Tryptic digestion of in-gel proteins for mass spectrometry analysis / Mai-Loan Huynh, Pamela Russell, and Bradley Walsh -- Database interrogation algorithms for identification of proteins in proteomic separations / Patricia M. Palagi, Frédérique Lisacek, and Ron D. Appel -- Creating 2DE databases for the world wide web / Christine Hoogland, Khaled Mostaguir, and Ron D. Appel.
  • Homeostasis involves a delicate interplay between generative and degenerative processes to maintain a stable internal environment. In biological systems, equilibrium is established and controlled through a series of negative feedback mechanisms driven by a range of signal transduction processes. Failures in these complex communication pathways result in instability leading to disease. Cancer represents a state of imbalance caused by an excess of cell proliferation. In contrast, neurodegeneration is a consequence of excessive cell loss in the nervous system. Both of these disorders exhort profound tolls on humanity and they have been subject to a great deal of research designed to ameliorate this suffering. ...--Foreword.
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  • Two-component signaling systems. Part A-C pt. A-B, C, 2007, 2010.
    ScienceDirect
    pt. B, 2007 ScienceDirect
    pt. C, 2010 ScienceDirect
    Pt. A. Computational analyses of sequences and sequence alignments ; Biochemical and genetic assays of individual components of signaling systems ; Physiological assays and readouts -- Pt. B. Structural approaches ; Reconstritution of heterogeneous systems ; Intracellular methods and assays ; Genome-wide analyses of two-component systems.
  • This book reviews current knowledge of the etiopathogenesis, pathophysiology, and molecular biology of tympanic membrane retraction pockets and provides clear guidance on clinical assessment and treatment. A new diagnostic approach based on clinicoradiologic correlations is presented, and the ability of computer tomography to offer objective criteria for improved differentiation between stable and unstable or unsafe retraction pockets is explained. Surgical options are discussed, and on the basis of their own clinical and surgical experiences the authors propose a novel procedure, masto-atticotomy with anterior epitympanotomy (AER surgery), which addresses the causative factors underlying a retraction pocket. This surgery aims to restore adequate aeration routes for the middle ear compartments situated above the tympanic diaphragm; it results in better control of the pathology and in most cases prevents its recurrence. The book will assist otologists and surgeons in ensuring that retraction pockets are effectively diagnosed and treated, avoiding progression to cholesteatoma.
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    Tympanoplasty -- Myringoplasty, meatoplasty, and canalplasty -- Ossiculoplasty -- Special applications with tympanoplasty -- Mastoidectomy and epitympanectomy -- Special applications of mastoidectomy -- Stapedotomy and stapedectomy -- Special applications of stapes surgery -- Conventional and multiplanar high-resolution computed tomography of the temporal bone -- Imaging for tympanoplasty and mastoidectomy -- Imaging for Stapes surgery -- Rules and hints -- MIcrosurgical equpiment.
  • Endocrine and Metabolic Responses to Exercise / Kostas Tsintzas and Ian A. MacDonald -- The Impact of Type 1 Diabetes on the Physiological Responses to Exercise / Michael C. Riddell Ph.D. -- Pre-exercise Insulin and Carbohydrate Strategies in the Exercising T1DM Individual / Richard M. Bracken, Daniel J. West and Stephen C. Bain -- Physical Activity in Childhood Diabetes / Krystyna A. Matyka and S. Francesca Annan -- The Role of Newer Technologies (CSII and CGM) and Novel Strategies in the Management of Type 1 Diabetes for Sport and Exercise / Alistair N. Lumb -- Hypoglycemia and Hypoglycemia Unawareness During and Following Exercise / Lisa M. Younk and Stephen N. Davis -- Fueling the Athlete with Type 1 Diabetes / Carin Hume -- Diabetes and Doping / Richard I. G. Holt -- Synthesis of Best Practice / Ian Gallen -- The Athlete's Perspective / Christopher J. Pennell, Jen Alexander, Mark S. Blewitt, Russell D. Cobb and Sebastien Sasseville, et al.
  • Epidemiology of Type 2 Diabetes -- Pathogenesis of Type 2 Diabetes Mellitus -- Metabolic mechanisms of muscle insulin resistance -- Fat metabolism in insulin resistance and Type 2 Diabetes -- Detection and diagnosis of Type 2 Diabetes - Therapies for delay or prevention of Type 2 Diabetes -- Postprandial hyperglycemia -- Medical nutrition therapy in Type 2 Diabetes -- Exercise as an effective treatment for Type 2 Diabetes -- Type 2 Diabetes Mellitus: an evidence-based approach to practical management: noninsulin pharmacological therapies -- The transition from oral agents to combination insulin/oral therapy -- Intensive insulin therapy in T2DM -- Hypoglycemia in Type 2 Diabetes -- Type 2 Diabetes and concomitant illness: the prepared practice -- Adherence to practice guidelines for people with Diabetes Mellitus -- Treatment of hypertension in Type 2 Diabetes -- Lipoproteins in Diabetes: risk and opportunity -- Management of coronary artery disease in Type 2 Diabetes Mellitus -- Peripheral vascular disease and stroke in Type 2 Diabetes -- Obesity and its treatment in Type 2 Diabetes -- The liver in Type 2 Diabetes Mellitus -- Developing criteria for defining Type 2 Diabetes in pregnancy -- Metabolic complications of polycystic ovary syndrome -- Erectile dysfunction in Diabetes -- Sexual dysfunction in women with Type 2 Diabetes -- Depression in Type 2 Diabetes -- Atypical forms in Type 2 Diabetes -- Diabetes Mellitus Type 2 and stress: pathophysiology and treatment -- Pharmacologic factors affecting glycemic control -- Influencing self-management: from compliance to collaboration.
  • Pathophysiology of type 2 diabetes -- Guidelines and classifications -- Exercise -- Nutrition -- Obesity and the metabolic syndrome -- Oral agents for type 2 diabetes -- Insulin use -- Macrovascular disease -- Microvascular disease -- Diabetic dyslipidemia -- Hypertension in diabetics -- Glycemic control -- Risk reduction in the diabetic patient.
  • Pathophysiology of type-2 diabetes -- Guidelines and classifications -- Exercise -- Nutrition -- Obesity and the metabolic syndrome -- Oral agents for type-2 diabetes -- Insulin use -- Non-insulin injectables -- Macrovascular disease -- Microvascular disease -- Diabetic dyslipidemia -- Hypertension in diabetics -- The pathophysiology and metabolic impact of hyperglycemia -- Risk reduction in the diabetic patient -- Diabetes in special populations.
  • Tyrosine kinase inhibitors for gastrointestinal stromal tumor / Peter Reichardt -- Gastrointestinal stromal tumor pathophysiology & drug targets / Eva Wardelmann -- Imatinib / Sebastian Bauer & Michael Montemurro -- Sunitinib / Wen Wen Shan & Charles D. Blanke -- Other tyrosine kinase inhibitors in clinical trials / Maria Debiec-Rychter & Sebastian Bauer -- Other tyrosine kinase inhibitors in development and future directions / Uwe Knippschild, Christian Peifer, Joachim Bischof & Klaus Kramer -- Index.

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Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides one-click access to important clinical resources; includes evidence-based diagnosis and treatment guidelines, Books, EBM articles, Ovid MEDLINE, Drug facts and comparisons, Drug interaction facts, guidelines from National Guideline Clearinghouse, patient handouts (English and Spanish), and local content.ClinicalKey provides access to textbooks, electronic journals, practice guidelines, drug information, and patient education handouts.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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