Books

Summary: This book describes the anatomy and biomechanics of the trapeziometacarpal joint and explains the pathogenesis and treatment of trapeziometacarpal joint osteoarthritis, also known as rhizarthrosis. The discussion of treatment sets out both conservative and surgical approaches, clearly explaining the indications for the various options, as well as their advantages and disadvantages. The trapeziometacarpal joint is a phylogenetically recent articulation that permits the pinching movements of the index finger and thumb so important in daily activities. Degenerative disease involving the trapeziometacarpal joint is an important disabling condition that affects predominantly females over 50 years old. Although a number of treatments are now available, there is no single gold standard. Conservative treatments can control pain yet are unable to halt progression of the articular aging, while none of the surgical solutions employed when conservative treatments prove insufficient can be considered perfect. For example, use of a spacer can restore strength but does not always completely alleviate pain while arthroplasty eradicates pain within a few weeks but cannot restore strength. In thoroughly reviewing the available treatments, this book will enable the practitioner to select the best option for the individual patient.

Contents:
Anatomy of the trapeziometacarpal joint
Physical and radiological evaluation
Etiopathology
Non-surgical treatment
Portals in the arthoscopy of the wrist and of the small joints
Trapeziometacarpal joint arthrosis : arthroscopic treatment
Surgical approaches and techniques.

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Summary: "Unparalleled in its breadth and depth of expertly crafted content, Trauma takes you through the full range of injuries you are likely to encounter. With a full-color atlas of anatomic drawings and surgical approaches, this trusted classic provides thorough coverage of kinematics and the mechanisms of trauma injury, the epidemiology of trauma, injury prevention, the basics of trauma systems, triage, and transport, and more. It then reviews generalized approaches to the trauma patient, from pre-hospital care and managing shock, to emergency department thoracotomy and the management of infections; delivers a clear, organ-by-organ survey of treatment protocols; and shows how to handle specific challenges in trauma--including alcohol and drug abuse, and combat-related wounds--in addition to post-traumatic complications such as multiple organ failure."--From the publisher.

Summary: This book has two goals: to educate healthcare professionals about the effect of identity-based adversity on the health of their LGBT patients, and to outline how providers can use the clinical encounter to promote LGBT patients' resilience in the face of adversity and thereby facilitate recovery. Toward this end, it addresses trauma in LGBT populations; factors that contribute to resilience both across the lifespan and in specific groups; and strategies for promoting resilience in clinical practice. Each chapter includes a case scenario with discussion questions and practice points that highlight critical clinical best practices. The editors and contributors are respected experts on the health of LGBT people, and the book will be a "first of its kind" resource for all clinicians who wish to become better educated about, and provide high quality healthcare to, their LGBT patients.

Contents:
PART 1: OVERVIEW OF TRAUMA IN LGBT POPULATIONS
1. Intersection of Trauma and Identity
2. Medical Intervention and LGBT People: A Brief History
3. Conceptualizing Trauma in Clinical Settings: Iatrogenic Harm and Bias
4. Impact of Stress and Strain on Current LGBT Health Disparities
PART 2: RESILIENCE ACROSS THE LIFESPAN
5. The Role of Resilience and Resilience Characteristics in Health Promotion
6. Childhood and Adolescence
7. Resilience Across the Lifespan: Adulthood
8. Older Adults
PART 3: RESILIENCE IN SPECIFIC POPULATIONS
9. Transgender and Gender Nonconforming Individuals
10. Understanding Trauma and Supporting Resilience with LGBTQ People of Color
11. LGBT Forced Migrants
12. Lesbian and Bisexual Women
13. Institutionalization and Incarceration of LGBT Individuals
PART 4: RESILIENCE PROMOTION IN CLINICAL PRACTICE
14. An Overview of Trauma-Informed Care
15. Screening and Assessment of Trauma in Clinical Populations
16. Patients and their Bodies: The Physical Exam
17. Motivational Interviewing for LGBT Patients
18. Promoting Healthy LGBT Interpersonal Relationships
19.Community Responses to Trauma
20. Resilience Development among LGBT Health Practitioners.

Contents:
1. Treating the Critically Injured Military Patient / Sam D. Hutchings
2. Evolution and Organisation of Trauma Services / C. Andrew Eynon
3. Pre-hospital Management of the Critically Injured Patient / Paul S. C. Rees
4. The Trauma Team and Initial Management of the Critically Injured Patient / Simon J. Mercer
5. Haemodynamic Resuscitation Following Traumatic Haemorrhagic Shock: An Overview / William R. O. Davies and Sam D. Hutchings
6. Haemodynamic Optimisation of the Critically Injured Patient / William R. O. Davies and Sam D. Hutchings
7. Blood Product and Fluid Therapy in the Critically Injured Patient / William R. O. Davies and Sam D. Hutchings
8v Management of the Patient with Trauma Induced Coagulopathy / Sam D. Hutchings and Catherine M. Doran
9. Thoracic Trauma and Management of Ventilation in the Critically Injured Patient / Michael C. Reade
10. Management of Blast Related Injuries / Emrys Kirkman and Michael C. Reade
11. Managing Severe Traumatic Brain Injury Outside of the Neurosciences Critical Care Unit / George Evetts and Sam D. Hutchings
12. Management of the Critically Ill Burns Patient / Anthony D. Holley
13. General Surgical Problems in the Critically Injured Patient / David N. Naumann and Mark Midwinter
14. Orthopaedic Problems in the Critically Injured Patient / Edward Spurrier and Sarah A. Stapley
15. Imaging the Critically Injured Patient / David A. T. Gay and Jonathan Crighton
16. Management of Sedation, Analgesia and Delirium in Critically Injured Patients / Stephen Lewis and Kate Prior
17. Nutrition in the Critically Injured Patient / Stephanie R. Strachan and Karen Friend
18. Venous Thromboembolism in Critically Injured Patients / Ian Ewington
19. Aeromedical Evacuation and Transfer of the Critically Injured Patient / Ian Ewington.

Contents:
Introduction
The Relevance of Trauma in Immigrants
Cross-cultural Communication with Traumatised Immigrants
Cross-cultural Competence in Handling with Traumatised Immigrants
Clinical Diagnostic of Traumatised Immigrants
Treatment Process of Traumatized immigrant Children and Adolescent
Trauma-centered Therapy with EMDR
Refugees and Asylum Seeker and Trauma
Expert Opinion of Traumatised Immigrants
Injured Helper
Immigrants in an Outpatient Clinic for Traumatised Immigrants
Cross-cultural Psychotherapy with Immigrants from Operational Zone
Therapy Concept for Traumatised Refugees in Denmark
Rethinking Trauma as a Global Challenge.

Summary: This atlas presents common and rare traumatic conditions of the retina and related intraocular tissues (choroidal rupture, commotio retinae, intraocular foreign body). It also covers intraocular tumors and congenital conditions such as myelinated retinal nerve fibers. Including numerous high-quality figures using various modalities, the book reviews the basic management principles in a reader-friendly style to help readers gain a better understanding of the diseases discussed. Trauma and Miscellaneous Disorders in Retina is one of nine volumes in the series Retina Atlas. This series provides comprehensive information on vitreoretinal diseases, covering imaging basics, retinal vascular disease, ocular inflammatory disease, retinal degeneration, retinal surgery, macular disorders, ocular oncology, pediatric retina and trauma.

Contents:
Posterior segment trauma and choroidal folds
Choroidal rupture
Commotio retinae
Valsalva retinopathy
Purtscher's retinopathy
Subhyaloid hemorrhage, traumatic macular hole and electric burn
Retained intraocular foreign body
Traumatic optic pit maculopathy
Optic nerve avulsion and hemorrhagic choroidal detachment
Congenital optic disc pit
Melanocytoma of optic nerve
Optic disc drusen
Retinal diseases in pregnancy
Cancer therapy-associated retinopathy
Myelinated retinal nerve fibers
Synchisis scintillans and asteroid hyalosis.

Summary: Reporting on classification systems which are currently utilised in the clinical setting, this illustrated guide is an essential resource for all young clinicians and researchers of Trauma and Orthopaedics. Each chapter of the different anatomical sites and pathologies is designed to assist the decision making of the readers regarding treatment strategy as well as informed consent of their patients. Trauma and Orthopaedic Classifications: A Comprehensive Overview includes classifications relevant to both Elective Orthopaedic Practice and Orthopaedic Trauma. Clear graphic illustrations accompany the description of all different classification schemes in a comprehensive manner, together with a structured presentation of existing clinical evidence. Surgeons in training right through to senior surgeons and academic clinicians will find this book to be a key reference to formulate the right decisions in their clinical practice.

Contents:
Upper limb trauma
Upper limb pathology
Spine trauma
Spine orthopaedic pathology
Lower limb trauma
Lower limb pathology
General trauma
Orthopaedic pathology ? Oncology.

Summary: "PTSD is a chronic, under-detected and under-treated psychiatric consequence of trauma that is often linked to new-onset medical and psychological conditions, impaired quality of life and long-term disability across the globe. This book is the first systematic analysis of the rates, risk factors, consequences and global burden of trauma and PTSD across a variety of wealthy and underdeveloped settings. An analysis of a global survey conducted by the World Health Organization and featuring findings from over 70,000 participants around the world, this text demonstrates a unique perspective on the prevalence of exposure to trauma and PTSD and the impact it has on population health. The findings inside this text underscore the urgent need for policymakers and healthcare providers to prioritize interventions aimed at reducing the burden of trauma, PTSD and its consequences"--Provided by publisher.

Summary: Managing a trauma center involves complex clinical care, long nights and days, administrative work, self-examination, critical review of patient care and significant regulatory requirements. Performance improvement is the key element of trauma center effectiveness. No trauma center provides flawless care, thus all centers have opportunities to improve. A competent performance improvement program is critical to trauma center outcomes. This book provides key information on all aspects of trauma PI program management. In some ways, PI is an art more than a science, so the more interaction program leaders have with strong PI programs, the more they can learn about how to improve their processes. The book outlines the generally accepted processes for identification of opportunities for improvement, which are the key component of performance improvement. This includes: rounding with care teams, contemporaneous chart review, audit filters, and voluntary submissions to the trauma program for review. This book explains how to triage opportunities for improvement, analyze them, form corrective actions, and finally achieve loop closure. The book covers the roles of the personnel in the PI program, what is required to dissect the opportunity to determine action plans, how to document the entire process, and how to keep track of opportunities for improvement to ensure that your program is progressively improving care. The final sections of the book deal with specific opportunities for improvement, action plans, and loop closure through the use of case studies. The book serves as a follow-up to Dr. Jeffrey Young's recently published book Trauma Centers, which serves as a quick guide to the key components of trauma center administration, management, and patient care.

Contents:
What is PI? (and what it is not)
Philosophy of PI
PI Techniques and Tools
Program personnel and regulatory requirements
Program setup
Trauma registries and other data sources
Event identification
Levels of review
Documentation of PI process and meeting minutes
Loop closure
Types of issues
Complex opportunities for improvement and difficult loop closure
Inspection of PI process by reviewers
Performance Improvement Case Studies.

Summary: This book is a quick guide to the key components of trauma center administration, management, and patient care. This book provides essential information for hospitals working toward trauma center designation, and for established trauma centers who want to improve their performance. This book provides trauma center personnel with a comprehensive overview of trauma center administrative structure, basic clinical operations, performance improvement and site visit preparation and examines the most common critical injuries seen by trauma centers to demonstrate how a properly functioning center addresses multiple priorities in critically ill patients. This book provides critical information for hospitals looking toward becoming a trauma center and established trauma centers that wants to improve their performance.

Contents:
1. Introduction
2.Trauma Center Structure
3.Trauma Center Leadership
4. Trauma Center Operations
5.Treatment of Injured Patients
6.Fundamentals of Performance Improvement
7. Performance Improvement Processes
8.Guideline Creation and Implementation
9. Benchmarking and Optimization of Care
10. Your American College of Surgeons or State Trauma Center Site Visit
11.Case Studies.

Summary: This book offers an overview of acute care surgery around the world, focusing on the four main branches of this novel subdiscipline: trauma, general emergencies, critical care, and rescue surgery. The book's primary goal is to provide a general view of acute care surgery, while addressing the most important issues in depth. The content is divided into three parts, the first of which is dedicated to the general organization of trauma centers, including the composition of modern trauma teams. Protocols of activation and action for the trauma team, as well as damage control procedures both in the emergency room and in the surgical theatre, are described. The book also addresses the development of a trauma registry, together with the quality assessment process that can be applied. In turn, the second part describes the principal protocols for making diagnoses, with special attention to circumstances such as unstable hemodynamics, neurological deterioration, normal vital signs, and penetrating injuries. The book subsequently deals with the most important aspects of trauma to the abdomen, chest, and pelvis, with notes on both surgical and intensive care issues. Practical descriptions of how to treat principal injuries to various organs are also provided. Finally, the third part of the book is dedicated to the most frequent general surgical emergencies and rescue surgical approaches, and includes information on diagnostic support with point of care ultrasound and endoscopic advanced techniques. Presenting cutting-edge strategies, this book will be of interest to professionals involved in surgical and intensive care for emergency conditions, such as colonic perforations, obstructions, acute pancreatitis, biliary tree stones, and caustic injuries.

Contents:
1 The tale of two cities: the development of trauma and acute care surgery
2 Organization and training in trauma and acute care surgery in Italy
3 The development of a regional trauma registry
4 Quality assessment in acute care surgery
5 Diagnostic protocols in trauma care
6 Damage control surgery. An Update
7 Damage control resuscitation and massive transfusion
8 REBOA in exanguinating torso haemorrhage
9 Definitive Care of abdominal solid organ injuries
10 Trauma to the chest: the role of trauma surgeon
11 Abdomino-pelvic trauma
12 The open abdomen: indications and techniques
13 Entero-atmospheric fistula: a challenge of acute care surgery
14 Operative endoscopy in acute care surgery
15 Point of Care Ultrasounds in acute care surgery
16 Large bowel emergencies
17 Biliary emergencies
18 Step-up approach in acute pancreatitis
19 Source control in abdominal sepsis
20 Laparoscopy in acute care surgery
21 Caustic injuries.

Summary: The Golden Hour is a well-established concept in emergency medicine, related to the critical period of one hour after an injury, accident or trauma. This term implies that the mortality rates increase substantially if efficient care is not provided within 60 minutes after the trauma. This book is intended as a practical manual in Trauma Care within the context of the golden hour, addressing all trauma types and all body parts. Readers will find essential decision-making algorithms and protocols with commentary for traumas, along with easily accessible information on how to treat patients in a very practical and handy fashion. Furthermore, the content is presented in a didactic way suitable for a wide audience, from medical students who want to learn about the basics of trauma care to experienced surgeons seeking a comprehensive guide to trauma-related interventions. The book combines contributions from experts at two renowned Trauma Centers, the Hospital do Trabalhador at Curitiba, Brazil, and the Ryder Trauma Center in Miami, USA. Therefore, considering the different local environments and resources, the book provides distinct perspectives for several injuries, presenting the state of the art in Trauma Care. The diversity of perspectives in this book contributes to a global health care approach suitable for trauma-related events from developed countries to remote areas. The Trauma Golden Hour - A Practical Guide celebrates the Centennial Anniversary of the Federal University of Parana (Brazil), the 25th Anniversary of the Ryder Trauma Center (USA) and the 20th Anniversary of the Hospital do Trabalhador (Brazil).

Contents:
Intro; Foreword; Preface; Contents; Contributors;
1: A Brief History of Trauma; 1.1 The Evolution of Trauma; 1.2 The Historical Foundations of Trauma Care; 1.3 History and Development of Trauma Care Systems; References;
2: Trauma Epidemiology; References;
3: Critical Care in Trauma; 3.1 Introduction; 3.2 ICU Structures; 3.3 Basics of ICU Care; 3.3.1 Ventilatory Support; 3.3.2 When to Intubate; 3.3.3 How to Intubate; 3.3.4 Weaning and Extubation; 3.3.5 Principles and Goals of Sedation; 3.3.6 Prevention of Pneumonia 3.3.7 Deep Vein Thrombosis Pulmonary Embolism Prophylaxis and ManagementBibliography;
4: Injury Severity Scoring; 4.1 Introduction; 4.2 The Injury Scores; 4.2.1 Anatomic-Based Scores; 4.2.2 Physiologic-Based Scores; 4.2.3 Combined Scores; References;
5: Trauma Systems, Trauma Registries, and Prehospital Triage; 5.1 Trauma Systems; 5.2 Trauma Registries; 5.3 Prehospital Triage; 5.4 Special Considerations; Bibliography;
6: Initial Trauma Care; 6.1 Introduction; 6.2 Preparation; 6.3 Primary Evaluation and Management; 6.4 Airway with C-Spine Protection 6.5 Breathing and Ventilation6.6 Circulation with Hemorrhage Control; 6.7 Disability: Neurological Status; 6.8 Exposure and Environmental Control; References;
7: Airway Management; 7.1 Conclusion; Bibliography;
8: Management of Shock; 8.1 Introduction; 8.2 Hemorrhagic Shock; 8.3 Neurogenic Shock; 8.4 Septic Shock; 8.5 Cardiogenic Shock; 8.6 Obstructive Shock (Hypertensive Pneumothorax); 8.7 Algorithm; 8.8 Conclusion; Bibliography;
9: Resuscitative Thoracotomy in Emergency Department; 9.1 Introduction; References;
10: Traumatic Brain Injury; 10.1 Introduction; 10.2 Conclusion
17: Pulmonary Trauma17.1 Clinical Evaluation; 17.2 Thoracic Lesions; 17.3 Pain; 17.4 Pneumothorax; 17.5 Hemothorax; 17.6 Pulmonary Contusion; 17.6.1 Rib Fractures; 17.7 Associated Injuries; 17.8 Conclusion; Bibliography;
18: Great Vessels and Cardiac Trauma; 18.1 Introduction; Bibliography;
19: Esophageal Trauma; 19.1 Conclusion; Bibliography;
20: Diaphragmatic Trauma; 20.1 Introduction; 20.2 Types of Trauma; 20.3 Symptoms; 20.4 Diagnosis; 20.5 Nonoperative Treatment; 20.6 Operative Treatment; 20.7 Complications; 20.8 Conclusion; References

Contents:
Historical Perspective of Trauma Induced Coagulopathy
Epidemiology of Hemorrhage-related Mortality
Cell-Mediated Hemostasis
Thrombin-Antithrombin System
Physiology of Hemostasis: Plasmin-antiplasmin system
Thrombin Formation
Platelets
Fibrinogen
Defining and Assessing the Endotheliopathy of Trauma and its Implications on Trauma Induced Coagulopathy and Trauma Related Outcomes
Protein C
Fibrinolysis Dysregulation following Trauma
Complement System
Neutrophils, Inflammation and Innate Immunity in Trauma-Induced Coagulopathy
Disseminated Intravascular Coagulation
Grading Clinical Coagulopathy and Predicting Massive Transfusion
Prothrombin and Partial Thromboplastin Time
Fibrinogen Assays
Rotational Thromboelastometry (ROTEM®)
Thromboelastography (TEG® 5000 and TEG® 6s Hemostasis Analyzers with TEG Manager® Software)
Red Blood Cell Transfusions
Plasma Transfusion
Cryoprecipitate/ Fibrinogen Concentrate Transfusions
Platelet Transfusion
Whole Blood for the Resuscitation of Massively Bleeding Civilian Patients
Adjunct Factor Replacement
Anti-fibrinolytics
Ratio Driven Massive Transfusion Protocols
Goal-Directed Massive Transfusion Management
Pre-Hospital Resuscitation
Venous Thromboembolism after Trauma
Fibrinolysis Shutdown and Venous Thromboembolism
Congenital and Acquired Hypercoagulable States
Pediatrics
Traumatic Brain Injury-Induced Coagulopathy
Blunt Solid Organ Injury: A Call for Timely Chemoprophylaxis in the Setting of Early Hypercoagulability
Pregnancy
Liver Failure
Pulmonary Coagulation in the Pathogenesis of Trauma-Associated Acute Respiratory Distress Syndrome
Management of Chronically Anticoagulated Patients
Randomized Controlled Trials: Informing Clinical Practice for Traumatically Injured Patients
The Quantra® System and SEER Sonorheometry
Dried Plasma for Trauma Resuscitation
Synthetic Blood Substitutes
Flow-Based Coagulation and Fibrinolysis Assays
Animal Models of Coagulopathy
Applications of Viscoelastic Hemostatic Assays at the Site of Care: Considerations and Implications.

Contents:
Trauma and the NICU experience
Core measures for age-appropriate care
Trauma-informed, age-appropriate care in the NICU
Summary : the need for standardization of trauma-informed age-appropriate care in the NICU
Guidelines for the healing environment
Guidelines for pain and stress prevention, assessment, management, and family
Guidelines for protected sleep
Guidelines for activities of daily living
Guidelines for family collaborative care
Meeting the needs of the neonatal clinician
Self-care guidelines for the neonatal clinician.

Summary: Interpersonal trauma is ubiquitous and its impact on health has long been understood. Recently, however, the critical importance of this issue has been magnified in the public eye. A burgeoning literature has demonstrated the impact of traumatic experiences on mental and physical health, and many potential interventions have been proposed. This volume serves as a detailed, practical guide to trauma-informed care. Chapters provide guidance to both healthcare providers and organizations on strategies for adopting, implementing and sustaining principles of trauma-informed care. The first section maps out the scope of the problem and defines specific types of interpersonal trauma. The authors then turn to discussion of adaptations to care for special populations, including sexual and gender minority persons, immigrants, male survivors and Veterans as these groups often require more nuanced approaches. Caring for trauma-exposed patients can place a strain on clinicians, and approaches for fostering resilience and promoting wellness among staff are presented next. Finally, the book covers concrete trauma-informed clinical strategies in adult and pediatric primary care, and women's health/maternity care settings. Using a case-based approach, the expert authors provide real-world front line examples of the impact trauma-informed clinical approaches have on patients' quality of life, sense of comfort, and trust. Case examples are discussed along with evidence based approaches that demonstrate improved health outcomes. Written by experts in the field, Trauma-Informed Healthcare Approaches is the definitive resource for improving quality care for patients who have experienced trauma. .

Contents:
Section I: Introduction and the Scope of the Problem
Trauma: A Pervasive Adverse Health Exposure
Trauma and the Medical Patient
Section II: Special Populations
Men / Men of Color
Immigrants and Cultural Competency
LGBTQ Persons
Section III: Helping Providers
Vicarious Traumatization and the PCP
Fostering Resilience and Self Care
Section IV: Clinical Strategies
Adult Primary Care
Gynecology/Women's Health
Family Practice / Pediatric Care
Conclusion.

Summary: Trauma surgery has increasingly become a specialized field inspired by different principles and philosophy. A good trauma surgeon is a surgeon who knows how to perform abdominal vascular, thoracic, urologic, gynecologic, and orthopaedic procedures and is able to repair multiple traumatic injuries in the best sequence possible. In this first volume, practical, up-to-date guidance is provided on the optimal critical care and ICU management of trauma patients. In addition, individual chapters focus on specific injuries in orthopaedic trauma (and especially spinal trauma) and neurotrauma, with the aim of providing a fresh view of the surgical approach and practical suggestions for improving the skills of treating surgeons. Educational issues and the organization of a trauma center are also covered. The volume will be a handy pocket guide for trainee surgeons and any surgeon, physician, or nurse who treats trauma patients. It will be particularly relevant for emergency department physicians, critical care and ICU doctors, orthopaedic surgeons, neurosurgeons, and professionals responsible for trauma care and decision making, programs of trauma education, or organization of a trauma center.

Contents:
1. Training, Education, and Decision-Making in Trauma Surgery / Hee Soo Jung and Lena M. Napolitano
2. Management of the Polytrauma Patient / David J.J. Muckart and Noel Naidoo
3. Damage Control Resuscitation / Juan Carlos Duchesne, Bruno Monteiro Pereira, and Gustavo Pereira Fraga
4. Principles and Philosophy of Damage Control Surgery / Fredric M. Pieracci and Ernest E. Moore
5. Surgical Treatment of Pelvic Fractures / Raffaele Pascarella, Luigi Rizzi, Claudio Castelli, and Rocco Politano
6. Surgery of the Cervical Spine Trauma / Federico De Iure and Luca Amendola
7. Surgery of the Thoracolumbar Spine Trauma / Ralf H. Gahr and Mathias Spalteholz
8. Trauma Surgery of the Extremities / Ralf H. Gahr and Matthias Spalteholz
9. Minimally Invasive Approach and Endovascular Techniques for Vascular Trauma / Joseph J. DuBose, Megan Brenner, and Thomas M. Scalea
10. Interventional Techniques for Hemorrhage Control in Trauma / Robert Short, Alan Murdock, Phillip Orons, and Andrew B. Peitzman
11. Management of Penetrating Neck Injuries / Patrizio Petrone, Juan M. Verde, and Juan A. Asensio
12. Acute Traumatic Brain Injuries and Their Management / Michael M. Krausz, Itamar Ashkenazi, and Jean F. Soustiel
13. Establishing a Trauma Service / David J.J. Muckart and Noel Naidoo
14. Multiple Organ Failure in Trauma Patients / Francesco Del Corso, Carlo Coniglio, Aimone Giugni, Francesca Mengoli, Francesco Boni, Ilaria Turriziani, Gregorio Tugnoli, Salomone Di Saverio, and Giovanni Gordini
15. Infections in Trauma Patients / Massimo Sartelli and Cristian Tranà.

Summary: Trauma surgery has increasingly become a specialized field inspired by different principles and philosophy. A good trauma surgeon is a surgeon who knows how to perform abdominal, vascular, thoracic, urologic, gynecologic, and orthopaedic procedures and is able to repair multiple traumatic injuries in the best sequence possible. In this second volume the focus is exclusively on thoracic and abdominal trauma, with coverage of injuries to all regions. The surgical techniques employed in managing such trauma are carefully described with the aid of high-quality illustrations. Exploratory surgery (via either laparotomy or laparoscopy), damage control surgery, and definitive surgery are all fully covered, and attention is drawn to important technical tips and tricks. The volume will be a handy pocket guide for trainee surgeons who are beginning to deal with severe multiple trauma patients, as well as for all general or specialty surgeons and professionals (including scrub nurses and theatre staff) who are involved in trauma care and wish to keep abreast of developments in this complex field.

Contents:
1. Trauma Laparotomy / Gustavo Pereira Fraga and Sandro Rizoli
2. Laparoscopy for Trauma: When, What, How? / Selman Uranues and Abe Fingerhut
3. Thoracic Damage Control / Dennis Y. Kim and Raul Coimbra
4. Vascular Damage Control / Kenji Inaba and Demetrios Demetriades
5. Pelvic Damage Control / Stefania Cimbanassi and Osvaldo Chiara
6. Surgical Treatment of Thoracic Trauma: Lung / Peter Fagenholz and George Velmahos 7. Surgical Treatment of Thoracic Trauma: Mediastinum / Sergio Nicola Forti Parri and Maurizio Boaron
8. Surgical Treatment of Liver and Biliary Tree Trauma / Walter L. Biffl and Carlton C. Barnett Jr.
9. Surgical Treatment of Spleen Trauma / Salomone Di Saverio, Eleonora Giorgini, Andrea Biscardi, Andrea Sibilio, Silvia Villani, Noel Naidoo, Fausto Catena, and Gregorio Tugnoli
10. Surgical Treatment of Duodenal Trauma / Cino Bendinelli and Osamu Yoshino
11. Surgical Treatment of Pancreatic Trauma / Ari K. Leppäniemi
12. Surgical Treatment of Gastric Injury / Francesco Buccoliero and Paolo Ruscelli
13. Traumatic Small Bowel and Mesentery Injuries (SBMI) / Giorgio Rossi, Salomone Di Saverio, Antonio Tarasconi, and Fausto Catena
14. Surgical Management of Traumatic Colon and Rectal Injuries / Rahul J. Anand and Rao R. Ivatury
15. Surgical Treatment of Kidney and Urinary Tract Trauma / Vassilis J. Siomos, David Sehrt, and Fernando J. Kim
16. Gynecological and Obstetric Injuries / Korhan Taviloglu
17. Major Retroperitoneal Vascular Trauma / Pieter H. Lubbert, Li C. Hsee, and Ian D. Civil
18. Abdominal Compartment Syndrome and Open Abdomen for Trauma / Stefano M. Calderale, Sergio Ribaldi, Gregorio Tugnoli, Eleonora Giorgini, and Salomone Di Saverio
19. Abdominal Wall Reconstruction and Biological Prosthesis / Roberto Manfredi, Federico Coccolini, Stefano Magnone, Paolo Bertoli, Dario Piazzalunga, and Luca Ansaloni
20. Penetrating Trauma of the Chest / Franklin L. Wright and Thomas J. Esposito
21. Operative Management of Penetrating Trauma of the Abdomen / Noel Naidoo, David J.J. Muckart, T.E. Madiba, and Salomone Di Saverio
22. Selective Nonoperative Management of Penetrating Trauma of the Abdomen / Pradeep H. Navsaria and Andrew J. Nicol.

Summary: This is the first book exploring the unique dynamics created by a multidisciplinary trauma team and how crisis management strategies can improve teamwork and communication and, potentially, improve patient resuscitation outcomes. Crisis resource management (CRM) is integral to the way that we manage ourselves, team members, and patients during emergency situations. It is essentially the ability to translate knowledge of what needs to be done into effective actions during a crisis situation. Building on the revolutionary American College of Surgeons Advanced Trauma Life Support (ATLS®) course, Trauma Team Dynamics illustrates the integration of the principles of CRM to team dynamics throughout the resuscitation ? from the scene, through pre-hospital care and transport, to the trauma bay, and finally to definitive care and beyond. The editors and contributors are international experts in trauma, critical care, emergency medicine, nursing, respiratory therapy, and pre-hospital care and include NASA- and United States military-affiliated experts. Trauma Team Dynamics is intended for use as both a day-to-day clinical resource and a reference text, and includes self-assessment questions as well as guidance on CRM curriculum design and implementation.

Contents:
1: Overview of Traumatic Brain Injury (TBI)
2: Neuroradiological Imaging of Traumatic Brain Injury
3: Neuropsychological Assessment of mTBI in Adults
4: Management of Moderate and Severe TBI
5: Sports Concussion
6: Blast-Related Concussion
7: Sleep/Wake Disturbances in Mild Traumatic Brain Injury Patients
8: Vestibular Consequences of Mild Traumatic Brain Injury (mTBI)
9: Post-Traumatic Headache
10: Epileptic and Non-Epileptic Seizures after Traumatic Brain Injury
11: Post-Traumatic Hypopituitarism: Neuroendocrine Dysfunction and Treatment
12: Visual Disturbances and Mild Traumatic Brain Injury (mTBI)
13: Mild TBI and Co-Occurring PTSD Symptoms in Service Member Populations
14: Behavioral and Psychiatric Comorbidities of TBI
15: Chronic Effects of TBI in a Military Population
16: Rehabilitation Following TBI
17: Interventions to Improve Cognitive Functioning after Traumatic Brain Injury (TBI)
18: Mild Traumatic Brain Injury (mTBI) Affects the Family, Not Just the Injured Individual
19: Pediatric Concussion Diagnosis, Management, and Rehabilitation
20: Chronic Traumatic Encephalopathy
21: Traumatic Brain Injury (TBI): Current Diagnostic and Therapeutic Challenges
Appendix: TBI Diagnostic Coding Practices and Procedures.

Summary: The Handbook of Clinical Neurology volume on traumatic brain injury (TBI) provides the reader with an updated review of emerging approaches to traumatic brain injury (TBI) research, clinical management and rehabilitation of the traumatic brain injury patient. Chapters in this volume range from epidemiology and pathological mechanisms of injury, and neuroprotection to long-term outcomes with a strong emphasis on current neurobiological approaches to describing the consequences and mechanisms of recovery from TBI. The book presents contemporary investigations on blast injury and chronic traumatic encephalopathy, making this state-of-the-art volume a must have for clinicians and researchers concerned with the clinical management, or investigation, of TBI.

Contents:
Traumatic brain injury rehabilitation medicine / David X. Cifu & Blessen C. Eapen
Epidemiology of traumatic brain injury / Jud C. Janak, Mary Jo Pugh & Jean A. Langlois Orman
Traumatic brain injury diagnosis classification and evaluation / Yevgeny Zadov & Nikole Zadov
Nonoperative management of acute traumatic brain injury / Ajit B. Pai
Complications of traumatic brain injury / John Dennis Alfonso, Blessen C. Eapen & David X. Cifu
Sensory and system deficits following brain injury / Neera Kapoor, John-Ross Rizzo, Derrick Allred & Carlos A. Jaramillo
Neuropharmacology in the medical management of acute traumatic brain injury / Emerald Lin, Neil N. Jasey, Christine Greiss & Peter Yonclas
Traumatic brain injury rehabilitation / Michael Yochelson & Amy Murphy
Imaging evaluation of traumatic brain injury / David F. Tate, Matthew W. Reid & Gerald E. York
Prognosis in traumatic brain injury / Heidi N. Fusco & Jaime M. Levine
Sports concussions / Daniel L. Santa Maria & Joshua Goodwin
Pediatric traumatic brain injury / Udayan Kulkarni & Charles Dillard
Disorders of consciousness / Brian D Greenwald & Min Jeong Park
Return to school and return to work after traumatic brain injury / Paul Wehman, Pamela Targett, Charles Dillard & Priya Chandan
Serum 'central nervous system specific' protein biomarkers of traumatic brain injury / Teresa M. Evans & William E. Haskins
Emerging therapies in traumatic brain injury / Diana S. Busingye, Renée J. Turner & Robert Vink
Complementary and alternative medicine in traumatic brain injury / Elizabeth Jayne Halmai & Rebecca N. Tapia.

Summary: This book is a clinical guide to the prevention and management of traumatic dental injuries, including crown and root fractures and luxation injuries, in children of all ages. Readers will find clear descriptions of the challenges posed by the pediatric population, the evaluation of injuries, diagnosis, management, and follow-up. Whenever available, evidence-based guidelines are used to inform clinicians of the most appropriate care for each type of injury. A holistic approach is adopted, taking into account the child's developmental stage and ability to tolerate the proposed treatment. When indicated, more advanced forms of behavior guidance are discussed to enable the delivery of safe and effective care that will allow the best outcome to be achieved. Often, traumatic dental injuries result in sequelae that compromise the health of the developing permanent teeth. These sequelae and appropriate treatment options are described along with innovative approaches designed to preserve bone and maximize future treatment possibilities. The book will be a valuable asset for both pediatric and general dentists.

Contents:
Intro; Preface; Contents;
1: Introduction: Epidemiology of Traumatic Dental Injuries; 1.1 Pediatric Trauma; 1.2 Trauma Management Education; 1.3 Incidence of TDIs; 1.3.1 Birth to 5 Years; 1.3.2 Age 6-12 Years; 1.3.3 Age 13-18 years; 1.4 Risk Factors; 1.4.1 Sports; 1.4.2 Overjet; 1.4.3 Bicycles; 1.4.4 Automobile; 1.4.5 Violence; 1.4.6 Attention-Deficit/Hyperactivity Disorder (ADHD); 1.4.7 Tongue Piercing; 1.4.8 Chronic Health Conditions or Physical Limitations; 1.4.8.1 Epilepsy; 1.4.8.2 Cerebral Palsy; 1.4.8.3 Intellectual Disability; 1.4.9 Iatrogenic Injuries 1.4.9.1 Prolonged Intubation of Neonate1.4.9.2 Intubation During General Anesthesia; 1.5 Treatment and Timing; 1.6 Guidelines; References;
2: Unique Challenges in the Pediatric Population; 2.1 Behavior Guidance; 2.2 Behavior Guidance Considerations; 2.2.1 Tell-Show-Do; 2.2.2 Positive Reinforcement; 2.2.3 Distraction; 2.2.4 Voice Control; 2.2.5 Escape; 2.2.6 Parent Presence; 2.2.7 Deferred Treatment; 2.2.8 Nitrous Oxide; 2.3 Advanced Behavior Guidance Techniques; 2.3.1 Protective Stabilization; 2.3.2 Minimal Sedation; 2.3.3 Moderate Sedation; 2.3.4 General Anesthesia 2.4 Consent2.5 Communication; 2.6 Parental Presence; 2.7 Growth and Development Considerations; 2.8 Child Abuse; References;
3: Physical Examination and Diagnosis; 3.1 Initial Assessment; 3.2 Patient/Family Interview; 3.3 Medical History; 3.4 Neurologic Evaluation; 3.5 Extraoral/Intraoral Examination; 3.5.1 Extraoral Examination; 3.5.2 Intraoral Examination; 3.6 Radiographic Evaluation; 3.7 Dental Office Preparation; References;
4: Primary Tooth Crown and Root Fractures; 4.1 Uncomplicated Crown Fracture; 4.1.1 Treatment Recommendations; 4.1.2 Prognosis; 4.1.3 Sequelae 4.1.4 Behavior Management4.2 Complicated Crown Fracture; 4.2.1 Treatment Recommendations; 4.2.2 Follow-Up; 4.2.3 Prognosis; 4.2.4 Sequelae; 4.2.5 Behavior Management; 4.3 Crown/Root Fracture; 4.3.1 Treatment Recommendations; 4.3.2 Follow-Up; 4.3.3 Prognosis; 4.3.4 Sequelae; 4.3.5 Behavior Management; 4.4 Root Fracture; 4.4.1 Treatment Recommendations; 4.4.2 Follow-Up; 4.4.3 Prognosis; 4.4.4 Sequelae; 4.4.5 Behavior Management; 4.5 Fractures of the Alveolar Process; 4.5.1 Treatment Recommendations; 4.5.2 Follow-Up; 4.5.3 Prognosis; 4.5.4 Sequelae 4.5.5 Behavior Management4.6 Patient Instructions; References;
5: Primary Tooth Luxation Injuries; 5.1 Concussion and Subluxation; 5.1.1 Treatment Recommendations; 5.1.2 Follow-Up; 5.1.3 Prognosis; 5.1.4 Sequelae; 5.1.5 Behavior Guidance; 5.2 Lateral Luxation; 5.2.1 Treatment Recommendations; 5.2.2 Follow-Up; 5.2.3 Prognosis; 5.2.4 Sequelae; 5.2.5 Behavior Guidance; 5.3 Extrusive Luxation; 5.3.1 Treatment Recommendations; 5.3.2 Follow-Up; 5.3.3 Prognosis; 5.3.4 Sequelae; 5.3.5 Behavior Guidance; 5.4 Intrusive Luxation; 5.4.1 Treatment Recommendations; 5.4.2 Follow-Up

Contents:
Parte I Arto superiore: Clavicola
Spalla
Omero: Diafisi
Avambraccio: Diafisi radiale e ulnare
Polso
Mano
Parte II Bacino e femore prossimale: Anello Pelvico
Acetabolo
Femore: Regione prossimale
Parte III Arto inferiore: Femore: Diafisi
Ginocchio
Gamba: Diafisi tibiale e peroneale
Caviglia
Piede
Parte IV : Peculiarità pediatriche: Inquadramento clinico-radiologico delle fratture pediatriche
Lesioni ossee traumatiche specifiche
Lesioni ossee non accidentali
Fratture del bacino
Fratture del gomito
Fratture delle ossa lunghe degli arti nel bambino. .

Summary: "Treatment of traumatic injuries is increasing in importance for physical therapists active in hospitals and private practice. In addition to the bone, joint, and soft tissue injuries incurred in sports, physical therapists are seeing more and more traumas associated with aging and with high-speed accidents. This great variety of injury types increases the complexity of treatment. Moreover, in recent years there has been a growing demand for the most complete restoration possible of both physical and psychological function. This is the principal objective of aftercare. Accordingly, this book focuses on a comprehensive presentation of individual injuries and their effect on function, as well as the guidelines and potential results of physical therapy treatment. It is addressed to students, practitioners, and teachers of physical therapy who must master and apply an understanding of the whole range of injuries, their consequences, and their treatment. "--Provided by publisher.

Contents:
Wound healing and wound treatment
Physical and chemical injuries
Surgical infections
Soft tissue injuries
Fractures
Treatment of bone injuries
Phlebothrombosis and embolism
Complications of fracture healing and treatment
Joint injuries
Skull injuries
Spinal injuries
Thoracic injuries
Abdominal injuries
Pelvic injuries
Injuries to the lower extremities
Injuries to the upper extremities
Multiple trauma.

Summary: Prevent, evaluate, and manage diseases that can be acquired in tropical environments and foreign countries with The Travel and Tropical Medicine Manual. Equips medical providers with the knowledge they need to offer effective aid, covering key topics in pre- and post-travel medicine, caring for immigrants and refugees, and working in low-resource settings. It's also the perfect source for travelers seeking quick, easy access to the latest travel medicine information.

Contents:
Section 1. PRE-TRAVEL ADVICE. Chp. 1. Approach to travel medicine and contents of a personal travel medicine kit
Chp. 2. Urban medicine: threats to travelers to cities in low-income nations
Chp. 3. Emerging infectious diseases and the international traveler
Chp. 4. Jet health
Chp. 5. Immunizations for travelers
Chp. 6. Malaria prevention
Chp. 7. Water disinfection
Chp. 8. Traveler's diarrhea: prevention and self-treatment
Chp. 0. Disequilibrium: jet lag, motion sickness, cold exposure, and heat illness
Section 2. ADVICE FOR SPECIAL TRAVELERS. Chp. 10. High altitude travel
Chp. 11. Dive medicine
Chp. 12. Travel advice for pediatric travelers
Chp. 13. Students traveling abroad
Chp. 14. Advice for women travelers
Chp. 15. Immunocompromised traveler
Chp. 16. Travel with chronic medical conditions
Chp. 17. Travel and mental health
Chp. 18. Pre-travel assessment and advice for expatriates and volunteers
Chp. 19. Health screening for immigrants, refugees, and international adoptees
Section 3. FEVER. Chp. 20 Travel-acquired illnesses associated with fever
Chp. 21. Malaria diagnosis and treatment
Chp. 22. Viral hepatitis in travelers and immigrants
Chp. 23. Leptospirosis
Chp. 24. Lyme disease
Chp. 25. Tuberculosis in travelers and immigrants
Chp. 26. Chagas Disease
Chp. 27. Human African Trypanosomiasis (sleeping sickness)
Chp. 28. Ebola Virus disease and hemorrhagic fevers
Chp. 29. Antibiotic-resistant bacteria in returning travelers
Chp. 30. Role of point-of-care testing in travel medicine
Section 4. DIARRHEA. Chp. 31. Approach to diarrhea in returned travelers
Chp. 32. Amebiasis, Giardiasis, and other intestinal protozoan infections
Chp. 33. Food poisoning: toxic syndromes
Chp. 34. Fish and shellfish poisoning: toxic syndromes
Section 5. DERMATOLOGY. Chp. 35. Approach to tropical dermatology
Chp. 36. Acute skin reactions and bacterial infections
Chp. 37. Ectoparasites, cutaneous parasites, and cnidarian envenomation
Chp. 38. Fungal skin infections
Chp. 39. Leishmaniasis
Chp. 40. Leprosy (Hansen's Disease)
Section 6. SEXUALLY TRANSMITTED DISEASES. Chp. 41. Sexually transmitted infections and foreign travel
Chp. 42. Gonococcal and chlamydial genital infections and pelvic inflammatory disease
Chp. 43. Syphilis
Chp. 44. Genital ulcer disease
Section 7. HELMINTHS. Chp. 45. Common intestinal roundworms
Chp. 46. Cestodes: intestinal and extraintestinal tapeworm: infections, including echinococcosis and cysticercosis
Chp. 47. Filarial infections
Chp. 48. Trematodes
Chp. 49. Eosinophilic patient with suspected parasitic infection
Appendix
Index.

Summary: "Today's travel medicine includes not only tourism and business travelers, but also incorporates volunteerism, medical care, migration, ecotourism, and more. Travel Medicine, 4th Edition, reflects all of these changes in the field while keeping you up to date with new vaccines and newly proposed regimens, pre-travel advice and post-travel screening, and all travel-related illnesses - for a one-stop, authoritative reference on all aspects of travel medicine"--Publisher's description"--Publisher's description.

Contents:
Section 1: Practice of travel medicine. Introduction to travel medicine
Epidemiology: morbidity and mortality in travelers
Starting, organizing and marketing a travel clinic
Pre-travel consultation
Section 2: The pre-travel consultation. Water disinfection for international travelers
Insect protection
Pre-travel considerations for non-vaccine-preventable travel infections
Travel medicine kits
Section 3: Immunization. Principles of immunization
Routine adult vaccines
Routine travel vaccines: hepatitis A and B, typhoid
Recommended/required travel vaccines
Pediatric travel vaccinations
Section 4: Malaria. Malaria: epidemiology and risk to the traveler
Malaria chemoprophylaxis
Self-diagnosis and self-treatment of malaria by the traveler
Approach to patient with malaria
Section 5: Travelers' diarrhea. Epidemiology of travelers' diarrhea
Prevention of travelers' diarrhea
Clinical presentation and management of travelers' diarrhea
Persistent gastrointestinal symptoms in the ill-returning traveler
Section 6: Travelers with special needs. The pregnant and breastfeeding traveler
The pediatric and adolescent traveler
The older traveler
The physically challenged traveller
The traveler with pre-existing disease
The immunocompromised traveller
The traveler with HIV
The business traveler
The VIP traveler: mission-oriented travel medicine
Health aspects of international adoption
Visiting friends and relatives
Section 7: Travelers with special itineraries. Expatriates: corporate, missionary and volunteer
The migrant traveler
Humanitarian aid workers
The deployed military: medical readiness and travel-related health issues
Expedition medicine
Ecotourism
Medical tourism
Cruise ship travel
Mass gatherings
Section 8: Environmental aspects of travel medicine. High-altitude medicine
Diving medicine
Extremes of temperature and hydration
Jet lag
Motion sickness
The aircraft cabin environment
Section 9: Health problems while traveling. Bites, stings, and envenoming injuries
Seafood poisining
Injuries and injury prevention
Mental health issues of travelers
Travelers' thrombosis
Healthcare abroad
Personal security and crime avoidance
Section 10: Post-travel. Post-travel screening
Fever in returned travelers
Skin diseases
Eosinophilia
Respiratory infections
Appendix. Sources of travel medicine information.

Summary: This is the first comprehensive and authoritative book to cover the basis for the joint prevention of stroke and the management, delay, or prevention of some dementias. It engages with the concept of cerebrovascular disease as asymptomatic, and provides overwhelming evidence that major dementias involve a vascular component, ranging from 60 percent in frontotemporal dementia to 80 percent in Alzheimer's disease--doubling the chances of silent brain pathology manifesting as dementia. Beginning with a review of the basics, describing typical patients and presentations, and providing clear guidelines in diagnoses, management, and prevention, this vital guide is invaluable for physicians dealing with cognitive impairments, including family physicians, psychiatrists, internists, geriatricians, and neurologists, worldwide. This book provides a new, coherent, and promising approach, filling the gap between what is known and what is applied, offering a great opportunity for appropriate interventions and treatments that make a difference. Improving outcomes, beginning now--back cover.

Contents:
Basics / Mahmoud Reza Azarpazhooh and Vladimir Hachinski
Diagnosis of potentially preventable dementias / Jose G. Merino and Clinton B. Wright
The brain at risk stage / Mahmoud Reza Azarpazhooh and Vladimir Hachinski
The patient with cognitive impairment / Krister Hakansson, Miia Kivipelto and Tiia Ngandu
Cognitive decline in transient ischemic attacks or minor strokes / Antonia Nucera, Mahmoud Reza Azarpazhooh and Vladimir Hachinski
The stroke patient and cognition / Michael Brainin and Yvonne Teuschi
Reversible dementias / Lawrence S. Honig
Prevention of dementia / J. David Spence.

Summary: Clinicians are now facing new substance use-related challenges such as the opioid crisis, a changing political landscape regarding marijuana, and the emergence of new delivery devices such as e-cigarettes. Unfortunately, it is more critical than ever that clinicians caring for adolescents have a proficiency in treating substance use. This book is a comprehensive clinical guide that discusses the prevalence of substance use among adolescents and young adults, as well as prevention strategies, available screening methods, practical treatment applications and their outcomes. Using a multidisciplinary approach with inclusion of authors from diverse clinical backgrounds, this definitive guide provides the best practices for treating adolescent substance use disorders from medical, behavioral, and social standpoints. Supplemented with case examples and written by experts in the field, Treating Adolescent Substance Use appeals to all clinicians that treat adolescent patients.

Contents:
General principles / Hans Steiner, Rebecca Hall, Julia Huemer
Disruptive behavior disorders / Whitney Daniels, Michael Kelly, Kathleen Ares, Katie Kaszynski, Niranjan Karnik
Attention-deficit/hyperactivity disorder (ADHD) / Michael Kelly
Learning and executive cognitive functions / Ahmed Khan, Brianna Bendixsen, Lynne Baldwin, Diana Barrett, Richard Abbey.

Contents:
Part I. Depression and bipolar disorder
Part II. Schizophrenia
Part III. Anxiety disorders
Part IV. Eating disorders
Part V. Substance use disorders
Part VI. Youth suicide and suicide attempts
Part VII. Beyond disorder
Part VIII. Other behavioral disorders
Part IX. Conclusions, recommendations, priorities.

Summary: Treating Feeding Challenges in Autism: Turning the Tables on Mealtime distills existing research on feeding disorders treatment into the very best, most effective and most practical strategies for practitioners to implement with their clients who have autism and other developmental and behavioral disorders. The book focuses on the few but highly effective feeding treatment procedures that work in the large percentage of cases. The book describes each procedure in practical, how-to language, with the goal of explaining how to implement them in the real-life settings in which practitioners actually work. The book includes a large variety of sample datasheets, intervention plans and graphs of sample data to serve as practical examples to guide clinicians through the process of selecting, implementing, analyzing and troubleshooting feeding interventions.

Contents:
Introduction
Medical and behavioral origins of feeding problems
Preparing for meals
Treatment components: positive reinforcement and escape extinction
Treatment components: antecedent variables
Common treatment packages
Treatment management
Caregiver training and follow-up
Troubleshooting.

Contents:
Classical bleeding disease
My encounter with hemophilia
The first years at novo nordisk
The development of recombinant FVIIa
The futher use and development of rFVIIa
Legal issues regarding the use of rFVIIa in hemophilia patients with inhibitors
Treatment with rFVIIa in Malmö --Mechanism of action and dosage
The continued development of rFVIIa during the 2000s
Three different descriptions of how rFVIIa was developed
Some final remarks.

Summary: The primary aim of this book is to equip physicians, psychologists, therapists, nurses, and other practitioners with a validated, step-by-step treatment for psychogenic nonepileptic seizures (NES) that can improve the lives of patients with this disabling disorder.

Contents:
Introductory Information for Therapists
Introductory Session: Understanding Seizures
Session 1: Making the Decision to Begin the Process of Taking Control
Session 2: Getting Support
Session 3: Deciding About Your Drug Therapy
Session 4: Learning to Observe Your Triggers
Session 5: Channeling Negative Emotions Into Productive Outlets
Session 6: Relaxation Training: Experiencing the Sensation of the Brain Changing Itself
Session 7: Identifying Your Pre-Seizure Aura
Session 8: Dealing With External Life Stresses
Session 9: Dealing With Internal Issues and Conflicts
Session 10: Enhancing Personal Wellness
Session 11: Other Symptoms Associated With Seizures
Taking Control: An Ongoing Process
Prognosis (Patient Outcomes)
When the Patient has a Seizure in the Office Setting
Workbook Appendices.

Summary: The latest information from the CDC demonstrates that 70% of Americans can be classified as having pre-obesity or obesity. This chronic disease is considered the cause of many other chronic diseases such as hypertension, dyslipidemia, diabetes, and nonalcoholic fatty liver disease, to name but a few of the 236 obesity associated disorders. Additionally, obesity is considered to be the cause of fourteen different types of cancers. Based on the number of people affected and the consequences of the disease, it is imperative that it is studied and treated by primary care providers. Few training programs for physicians, NPs or PAs are covering the basics of treating obesity. These fundamentals include pathophysiology, assessment of the disease, and the foundational components of treatment with eating plans, physical activity and behavioral interventions, then the supporting components of anti-obesity medications, devices and surgery. As a result, few of those currently in primary care practice have received any education in the evidence-based treatment of obesity. This book provides the reader with the education to understand the disease, the patients experience, and full evidence-based treatment. It also provides the opportunity to understand how to incorporate the treatment into primary care. Written by a leading expert in the field, Treating Obesity in Primary Care offers all clinicians providing primary care services the information needed to effectively treat the chronic disease of obesity.

Contents:
Section One: Understanding the disease
bias and issue
pathophysiology
obesity related complecations
Section Two: building a treatment plan
chronic disease model for obesity
evidence based guidelines
eating planc
Pphysical activity
behavior interventions
medications
procedures and surgery
Section Three: Putting it all together in clinic
billing
putting it all together in primary care
example in clinic.

Summary: This book describes a novel therapy for obesity that associates the traditional procedures of weight-loss lifestyle modification with specific, individualized cognitive behavioral procedures to address some obstacles that have been indicated by recent research to influence weight loss and maintenance. The Cognitive Behavioral Therapy for Obesity (CBT-OB) can be used to treat all classes of obesity, including patients with severe comorbidities and disability associated with obesity, who are not usually included in traditional weight-loss lifestyle modification treatments. The book describes the treatment program in detail, and with numerous clinical vignettes. It also discusses involving significant others in the change process and adapting the CBT-OB for patients with severe obesity, binge-eating disorder, medical and psychiatric comorbidity, and treated with weight-loss drugs or bariatric surgery. Lastly, a chapter is dedicated to the use of digital technology with CBT-OB in order to help patients monitor their food intake and physical activity and to addressing obstacles in real time. Thanks to the description of how to apply the latest, evidence-based CBT-OB to real world settings, this volume is a valuable useful tool for all specialists - endocrinologists, nutritionists, dietitians, psychologists, psychiatrists - who deal with obesity and eating disorders.

Summary: This book addresses opioids and opioid use disorders from epidemiological, clinical, and public health perspectives. It covers detailed information on the nature of opioids, their effects on the human body and brain, prevention, and treatment of opioid addiction. Unlike other texts, the first section of this volume builds a strong historical, neurobiological, and phenomenological foundation for a deep understanding of the topic and the patient. The second section addresses the most challenging issues clinicians face, including pharmacological and psychosocial treatments, harm reduction approaches, alternative approaches to pain management for the non-specialist, and prescribing guidelines. Treating Opioid Addiction is a valuable resource for psychiatrists, psychologists, addiction medicine physicians, primary care physicians, drug addiction counselors, students, trainees, scholars, and public health officials interested in the effects and impact of opioids in the clinical and epidemiological context. -- Provided by publisher.

Contents:
Intro; Foreword; Preface; Contents; Contributors;
1: Killing More than Pain: Etiology and Remedy for an Opioid Crisis; Introduction; Context: Origin and Growth in the Use of Opioids; Poppies, Pain, and Panacea; Killing More Than Pain: The Double-Edged Sword of Opioids; Conceptual Models for Understanding Drug Epidemics; Epidemiology of Opioid Misuse, Opioid Use Disorder, and Overdose Deaths; Addressing Opioid Misuse, Disorders, and Overdose Deaths; Reducing Supply and Accessibility to Opioids; Demand Reduction: Prevention, Treatment, and Recovery Support Services; Harm Reduction Strategies Conclusions and Future DirectionsReferences;
2: Epidemiology: Opioid Use and Related Disorders; Overview of the Medical Complications of Opioid Use and the Opioid Overdose Epidemic; Drivers of the Opioid Overdose Epidemic; Opioid Prescribing; Nonmedical Pharmaceutical Opioid Use; Heroin Use; Opioid Use Disorders; Illicitly Manufactured Fentanyl Use; Social, Political, and Economic Factors; Individual-Level Risk and Protective Factors for Opioid Overdose; Opioid Dose, Potency, Duration of Action, Tolerance, and Route of Administration; Polysubstance Use and Polypharmacy; Benzodiazepines AlcoholStimulants; Underlying Psychiatric and Medical Comorbidities; Treatment Medications; Conclusions and Implications for Prevention; References;
3: Neurobiology of Addiction: A Disorder of Choice; Introduction; Changes in Salience Detection; Key Systems; Neurobiological Changes; Behavioral Effects; Changes in Stress Signaling; Key Systems; Neurobiological Changes; Behavioral Effects; Changes in Cognition and Control; Key Systems; Neurobiological Changes; Behavioral Effects; Neurobiology of Opioid Addiction; Opioid-Related Neuroadaptations; Opioid Effects on Salience Detection Opioid Effects on Stress SystemsOpioid Effects on Cognition and Control Systems; Conclusion: Toward a Framework for Recovery; References;
4: Terminology and Conceptualization of Opioid Use Disorder and Implications for Treatment; Conceptualization of Opioid Addiction; Conceptualization of Opioid Use that Risks Health Consequences; Terminology for Opioid Use that Risks Health Consequences; Terminology for Opioid Use Disorder; Implications of Terminology for Treatment; Conclusions; References;
5: Medication for the Treatment of Opioid Use Disorder; Introduction; Treatment of Withdrawal Maintenance TreatmentAgonist Therapy; Buprenorphine; Obtaining the DEA Buprenorphine Waiver; Clinical Use of Buprenorphine; Methadone; Methadone Induction; Antagonist Therapy; Naltrexone; Diversion Control; Non-pharmacological Treatment; Treatment of Opioid Overdose; Additional Considerations; Acute Pain; Concurrent OUD and Other Mental Illness; Integrating Medication Treatment into a Comprehensive Recovery Program for OUD; References;
6: Psychosocial Approaches in the Treatment of Opioid Use Disorders; Introduction; Settings Where Psychosocial OUD Approaches May Be Delivered

Summary: This book aims to bring together the current research and discussions surrounding bladder cancer management. New technologies and therapeutic agents have become increasingly effective at treating urothelial bladder cancer and have created a range of opportunities to change the ways in which the disease is treated. Chapters cover the changes in adjuvant treatment, confocal laser endomicroscopy, and the roles of oncologists, pathologists, and radiotherapists in managing bladder cancer. Treating Urothelial Bladder Cancer is particularly relevant to urologists, oncologists, and radiotherapists, but is also applicable to practitioners, geriatricians, and public health managers due to its multidisciplinary approach to bladder cancer management.

Contents:
Bladder cancer diagnosis
Non-muscle invasive bladder cancer
Muscle invasive bladder cancer
A view on the future.

Summary: Patient adherence to a given treatment plan directly correlates to the quality of disease outcome. In looking at the how and why behind patient adherence and non-adherence to a treatment regimen, understanding realistic expectations of a patient can provide a beneficial guide towards providing optimal healthcare. Treatment Adherence in Dermatology offers insight and strategies for understanding and promoting treatment adherence with a focus on dermatological conditions, specifically psoriasis, atopic dermatitis, and acne. Reasons for non-adherence are investigated particularly in populations such as children and patients with multiple co-morbidities. The proposed text provides patient and physician-centered strategies alongside technological advancements to promote adherence. Written for the practicing dermatologist, this title will find audience with primary care physicians, students, residents, and other practicing doctors alike.

Contents:
Chapter 1. Reasons for Nonadherence
Chapter 2. Strategy to Monitor Adherence
Chapter 3. Strategies to Improve Adherence
Chapter 4. Psychological Techniques to Promote Adherence
Chapter 5. Adherence in Pediatric Populations
Chapter 6. Adherence in Patients with Comorbidities
Chapter 7. Adherence in Psoriasis
Chapter 8. Adherence in Atopic Dermatitis
Chapter 9. Adherence in Acne
Chapter 10. Technological Advancements to Promote Adherence.

Summary: "Treatment and Care of the Geriatric Veterinary Patient offers veterinarians a complete guide to treating and managing geriatric canine and feline patients. Offers practical guidance on managing all aspects of veterinary care in geriatric pets. Takes a holistic approach to managing the geriatric patient, from common diseases and quality of life to hospice, euthanasia, client communications, and business management. Focuses on dogs and cats, with a chapter covering common exotic animals. Provides clinically oriented advice for ensuring quality of life for older pets. Includes access to a companion website with client education handouts"--Provided by publisher.

Summary: This book equips the reader with a sound understanding of the treatment of neglected and vulnerable patients in the dental office. It offers a comprehensive multidisciplinary approach to atraumatic carious treatment, minimal intervention dentistry, TMJ affections and nutritional consequences. Maintaining proper oral health includes managing of oral hygiene, healthy diet and seeking for a treatment when needed. Untreated dental disease can have a significant adverse impact on the health, wellbeing and quality of life. This book helps practitioners to understand and address the needs of dental neglected adults and children, and guide them through prevention procedures, diagnostics and treatment planning. Important techniques like physiologic impression for removable denture, single crown impression, digital planning and prosthodontic bridges are explained, and socio-demographic and economic changes in Oral Health are discussed. The comprehensive coverage of the topic and the evidence based references make this book a must have for dental practitioners.

Contents:
Chapter 1: Oral Health: Ethical and Clinical Concerns
Chapter 2: Prevention for Vulnerable Patients: Atraumatic Carious Treatment and Mild-To-Moderate Periodontal Therapy
Chapter 3: Dental Neglect
Chapter 4: The Vulnerable Patients Group: The Global Oral Health Concept
Chapter 5: The TMJ Troubles and Their Nutritional Consequences
Chapter 6: Prevention Strategy - A Practical Protocol for Elderly Patients.

Summary: The relationship people have with their possessions ranges from purely utilitarian to intensely emotional. For most people, their personal possessions provide them with a sense of security, comfort, and pleasure. However, if someone loses the ability to distinguish useful or important possessions from those that make life overly complicated, the objects can become a prison. For people who suffer from Hoarding Disorder (HD), the process of getting rid of unneeded objects is not easy. For them, possessions never "feel" unneeded and trying to get rid of them is an excruciating emotional ordeal.

Contents:
Introduction to Hoarding Disorder
Evidence-based treatment for Hoarding Disorder
Assessing hoarding
Case formulation
Enhancing motivation
Planning treatment
Reducing acquiring
Training skills
Making decisions about saving and discarding
Cognitive strategies
Complications in the treatment of Hoarding Disorder
Maintaining gains
Appendices : Clinician session form
Hoarding interview
Hoarding rating scale
Saving inventory : revised (SI-R)
Clutter image rating (CIR)
Saving cognitions inventory (SCI)
Activities of daily living for hoarding (ADL-H)
Safety questions
Home environment inventory (HEI)
Scoring keys for assessment instruments
Blank model of hoarding
Brief thought record
Acquiring form
Clutter visualization form
Unclutter visualization form
Acquiring visualization form
Practice form
Thought record
Instructions for coaches
Family response to hoarding scale (FRHS).

Summary: "The relationship people have with their possessions ranges from purely utilitarian to intensely emotional. For most people, their personal possessions provide them with a sense of security, comfort, and pleasure. However, if someone loses the ability to distinguish useful or important possessions from those that make life overly complicated, the objects can become a prison. For people who suffer from Hoarding Disorder (HD), the process of getting rid of unneeded objects is not easy. For them, possessions never "feel" unneeded and trying to get rid of them is an excruciating emotional ordeal. This Second Edition of Treatment for Hoarding Disorder is the culmination of more than 20 years of research on understanding hoarding and building an effective intervention to address its myriad components. Thoroughly updated and reflective of changes made to the Fifth Edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-5), this second edition of the client Workbook and accompanying Therapist Guide outlines an empirically supported and effective CBT program for treating hoarding disorder. This Workbook is meant to guide clients through their treatment for hoarding disorder with their clinician. It includes homework, forms, exercises, and behavioral experiments for clients to test their personal beliefs about possessions, develop an organization plan and filing system, and sort and organize items room by room. A major goal of the treatment is to recapture the positive role of possessions in the lives of people with hoarding problems, and strategies are outlined for sustaining gains and making further progress, as well as for managing stressful life events that can provoke problematic acquiring and difficulty discarding"-- Provided by publisher. "This Second Edition of Treatment for Hoarding Disorder is the culmination of more than 20 years of research on understanding hoarding and building an effective intervention to address its myriad components. Thoroughly updated and reflective of changes made to the Fifth Edition of the Diagnostic and Statistical Manual for Mental Disorders (DSM-5), this second edition of the client Workbook and accompanying Therapist Guide outlines an empirically supported and effective CBT program for treating hoarding disorder"-- Provided by publisher.

Contents:
Introduction
Assessing hoarding problems
Developing your personal hoarding model
Planning your treatment
Reducing acquiring
Skills training
Making decisions about saving and discarding
Changing beliefs: thinking your way out of the hoarding box
Maintaining your gains
Appendix Forms
Personal session form (chapter 2)
Instructions for coaches (chapter 2)
Scoring key for assessments (chapters 2 & 9)
Brief thought record (chapter 3)
Hoarding model (chapter 3)
Practice form (chapter 4)
Downward arrow form (chapter 4)
Acquiring questions form (chapter 5)
Task list (chapter 6)
Personal organizing plan (chapter 6)
Preparing for organizing form (chapter 6)
Thought listing exercise form (chapter 7)
Questions about possessions form (chapter 7)
Behavioral experiment form (chapter 7)
Thought record form (chapter 8)
About the Authors
Index.

Summary: Edited and written by pioneers and experts in the field, Treatment of Acetabular Bone Loss and Chronic Pelvic Discontinuity is the first text to provide focused, practical content on the effective evaluation and treatment of this challenging problem. Comprehensive and easy to follow, it offers a step-by-step approach to teach surgeons how to tailor their surgery to each individual patient’s anatomy with the goal of improving patient outcomes.

Contents:
Introduction
Acetabular bone loss classification
Radiographic evaluation of severe acetabular bone loss +/– chronic pelvic discontinuity
Cementless acetabular revision (type I defects)
Cemented revision in type I defects
Cementless acetabular revision for the distorted acetabulum with intact columns (type IIA, B, and C defects)
Cemented acetabular revision for the distorted acetabulum with intact columns (type IIA, B, and C defects)
Cementless acetabular revision for severe acetabular bone loss without pelvic discontinuity (type IIIA and B defects)
Acetabular revision with impaction grafting for severe acetabular bone loss without pelvic discontinuity
Plating of an acute pelvic discontinuity
Intraoperative identification and bone grafting of a chronic pelvic discontinuity
Primer on treatment options for chronic pelvic discontinuity
Cages/ reconstruction rings (Burch-Schneider/ Ganz) for reconstruction of chronic pelvic discontinuity
Kerboull acetabular ring device with allograft for chronic pelvic discontinuity
Acetabular impaction bone grafting for chronic pelvic discontinuity
Acetabular bone loss with chronic pelvic discontinuity: Acetabular cup-cage vs cage-augment reconstruction
Cup-cage/half cage for chronic pelvic discontinuity
Ice cream cone (pedestal) prosthesis for chronic pelvic discontinuity
Custom triflange acetabular component for chronic pelvic discontinuity
Custom 3D-printed acetabular component for chronic pelvic discontinuity
Jumbo cup and modular porous metal augments for chronic pelvic discontinuity
Acetabular distraction technique for chronic pelvic discontinuity.

Summary: This comprehensive book presents an evidence-based approach to treating asthma in adults aged 65 and older, a vulnerable subset of patients who are more likely to experience higher morbidity and mortality rates, and often enduring higher financial burdens related to treatment. Treatment of Asthma in Older Adults: A Comprehensive, Evidence-Based Guide is a unique resource, providing an up-to-date review of medication strategies, how asthma phenotypes and treatment decisions interact, and how controlling asthma triggers impacts long-term asthma outcomes in older patients. Additionally, the book incorporates recent advances in alternative therapies that improve the patients quality of life. Opening discussions address the unique challenges of the differential diagnosis of asthma in older adults, as well as an examination of the significant medical comorbidities that co-exist with asthma. Subsequent chapters provide strategies to optimizing asthma management in this specific population, including information on case management that will assist allied health providers. Finally, the book closes with an analysis of several novel targets for therapy to treat severe asthma including biologics, macrolides and bronchial thermoplasty. Written by experts in the field, Treatment of Asthma in Older Adults: A Comprehensive, Evidence-Based Guide is an indispensable resource for allergists, pulmonologists, family physicians, physician assistants, nurse practitioners and all other allied clinicians.

Contents:
Introductory Chapters
1. Scope of the Burden of Asthma in Older Adults
2. Why is Asthma More Severe and Difficult to Control in Older Adults?
Section I: Challenges in the Diagnosis of Asthma in Older Adults
3. Difficulties in Physician and Self-Perception of Asthma in Older Adults
4. Objective Testing for Asthma in Older Adults
5. Distinguishing Asthma from Co-Morbid Conditions in Older Adults
Section II: Optimizing Effective Treatment of Asthma in Older Adults
6. Barriers to Effective Treatment of Asthma in Older Adults
7. Medication Efficacy and Side Effects in Older Asthmatics
8. Treatment of Asthma in Older Adults with Significant Medical Co-morbidities
9. Shared decision-making and Strategies to Optimize Adherence in Older Asthmatics
10. How Case Coordinators and Other Nursing Professionals Can Help Optimize Care of Asthma in Older Adults
11. The Impact of Specific Asthma Phenotypes on Treatment of Asthma in Older Adults
12. Controlling Triggers for Asthma in Older Adults: Environmental Allergens, Indoor and Outdoor Air Pollutants, and Infections
13. Novel and Alternative Therapies for Asthma in Older Adults.

Summary: Treatment of Benign Prostatic Hyperplasia: Modern Techniques is an up-to-date review of modern techniques used to treat benign prostatic hyperplasia. It provides a comprehensive review of both office and operating room based techniques. Both electrosurgical and laser based techniques are covered.These include high powered 532 nm laser photoselective laser vaporization of the prostate (PVP), holmium laser enucleation/ablation of the prostate (HoLEP/HoLAP), and Bipolar Electrovaporization of the Prostate (Bipolar EVP/Bipolar TURP). In addition, a comprehensive review of office based techniques and future therapies currently being developed is presented. Each of these techniques are presented in a balanced fashion with a focus on modern literature. Treatment of Benign Prostatic Hyperplasia: Modern Techniques will be of great value to Urologists, Urology Residents, Iternists, and Family Practitioners.

Contents:
Introduction
Principles of Electrocautery Based Techniques
Monopoloar TURP
Bipolar TURP
Plasmakinetic Vaporization
Principles of Laser Based Techniques
532nm Laser Photoselective Vaporization of Prostate
532nm Laser Enucleation/Resection Techniques
Holmium Ablation of Prostate
Holmium Enucleation of Prostate
Thulium Resection of Prostate
Thulium Enucleation of Prostate
Diode Laser Resection of Prostate (980nm)
Modern Open Prostatectomy
Laparoscopic/Robotic Simple Prostatectomy
Transurethral Microwave Therapy
Transurethral Needle Ablation
Prostatic Tissue Approximation
Prostatic Stents
Prostatic Artery Embolization
Ethanol Injection of Prostate.

Contents:
The current classification of bipolar disorders / Gin S. Malhi and Yulisha Byrow
Should the bipolar disorders be modelled dimensionally or categorically? / Gordon Parker and Amelia Paterson
The treatment of bipolar disorder on its early stages / Ajeet B. Singh, Harris A. Eyre, Edward Callaly and Michael Berk
Evidence-based treatment of mania / Bernardo Ng and Mauricio Tohen
The treatment of bipolar mixed states / Sarah Kittel-Schneider
The treatment of rapid cycling bipolar disorder / Konstantinos N. Fountoulakis and Dimos Dimellis
Evidence-based treatment of bipolar depression / Mark A. Frye, Paul E. Croarkin, Marin Veldic, Malik M. Nassan, Katherine M. Moore, Simon Kung, Susannah J. Tye, William V. Bobo, and Jennifer L. Vande Voort
Evidence-based maintenance treatment of bipolar disorder / Dina Popovic and Eduard Vieta
The treatment of bipolar II disorder / Lakshmi N. Yatham and Muralidharan Kesavan
The treatment of cyclothymia / Giulio Perugi, Giulia Vannucchi, and Lorenzo Mazzarini
Psychological interventions for early stage bipolar disorder / Jan Scott
Psychotherapeutic interventions for bipolar disorder / María Reinares
The role of psychoeducation in the management of bipolar disorder / Francesc Colom
Functional remediation therapy for bipolar disorder / Carla Torrent, Caterina del Mar Bronnin, and Anabel Martinez-Arán
Predominant polarity, polarity index, and treatment selection in bipolar disorder / Sabrina C. da Costa, Joao L. de Quevedo, and André F. Carvalho
The assessment and management of suicide risk in bipolar disorder / Zoltán Rihmer, Xénia Gonda, and Péter Döme
Treatment implications for bipolar disorder co-occurring with anxiety syndromes and substance abuse / Gustavo H. Vásquez, Alberto Forte, Sebastián Camino, Leonardo Tondo, and Ross J. Baldessarini
The impact of psychiatric co-morbidity in the treatment of bipolar disorder / Anna I. Guerdjikova, Paul E. Keck, Jr, and Susan L. McElroy
Bidirectional relationships between general medical conditions and bipolar disorder / Nefize Yalin, Danilo Arnone, and Allan Young
The treatment of bipolar disorder in women / Danielle Balzafiore, Thalia Robakis, Sarah Borish, Vena Budhan, and Natalie Rasgon
The treatment of bipolar disorder in children and adolescents / Philip Hazell
The treatment of bipolar disorder in the elderly / Gilberto Sousa Alves, Felipe Kenji Sudo, and Johannes Pantel
The management of treatment-resistant bipolar disorder / Salih Selek, Ives Cavalcante Passos, and Jair C. Soares
Staging and neuroprogression in bipolar disorder / Ives Cavalcante Passos and Flávio Kapczinski
Pharmacotherapy of bipolar disorder / Vicent Balanzá-Martínez, Sofia Brissos, Maria Lacruz, and Rafael Tabarés-Seisdedos
Cognitive enhancement in bipolar disorder / Kamilla W. Miskowiak and Lars V. Kessing
The role of electroconvulsive therapy in the treatment of bipolardisorder / Roumen Milev
Neuromodulatory approaches for bipolar disorder / Andre Russsowsky Brunoni, Bernando de Sampaio Pereira Júnior, and Izio Klein
The role of complementary and alternative therapies for the management of bipolar disorder / Arun V. Ravindran and Tricia L. da Silva
Novel therapeutic targets for bipolar disorder / Ioline D. Henter and Rodrigo Machado-Vieira
The treatment of bipolar disorder in the era of personalized medicine / Chiara Fabbri and Alessandro Serretti.

Contents:
1. Pain as a Perceptual Experience
2. Neuroplasticity, Sensitization, and Pain
3. Muscle Pain Treatment
4. Addictive Disorders and Pain
5. The "Five-Minute" Mental Status Examination of Persons with Pain
6. The Psychological Assessment of Patients with Chronic Pain
7. Psychological Therapies
8. Billing Psychological Services for Patients with Chronic Pain
9. Hypnosis and Pain Control
10. Acupuncture
11. Manual Therapies
12. Treatment of Chronic Painful Musculoskeletal Injuries and Diseases with Regenerative Injection Therapy (RIT): Regenerative Injection Therapy Principles and Practice
13. Interdisciplinary Functional Restoration and Pain Programs
14. Pain and Spirituality
15. Pain Disparity: Assessment and Traditional Medicine
16. Sleep and Chronic Pain
17. Empowerment: A Pain Caregiver?s Perspective
18. Patient and Caregiver?s Perspective
19. Pain Medicine in Older Adults: How Should It Differ?
20. Pain Medicine and Primary Care: The Evolution of a Population-Based Approach to Chronic Pain as a Public Health Problem
21. Pain Care Beyond the Medical Practice Office: Utilizing Patient Advocacy, Education, and Support Organizations
22. Neonatal Pain
23. Assessing Disability in the Pain Patient
24. The Double Effect: In Theory and in Practice
25. Failure to Treat Pain.

Contents:
1. A Survey of Systems Involved in Nociceptive Processing
2. Pharmacogenomics of Pain Management
3. Nonsteroidal Anti-inflammatory Drugs
4. The Role of Antidepressants in the Treatment of Chronic Pain
5. Anticonvulsant Medications for Treatment of Neuropathic and "Functional" Pain
6. NMDA Receptor Antagonists in the Treatment of Pain
7. Role of Muscle Relaxants in the Treatment of Pain
8. Topical Analgesics
9. Sleep Aids
10. Clinical Use of Opioids
11. Opioid Adverse Effects and Opioid-Induced Hypogonadism
12. Acute Management of the Opioid-Dependent Patient
13. Opioids and the Law
14. Methadone for Chronic Pain
15. Toxicology Screening for Opioids
16. Monitoring Drug Use and Abuse: The Evolution of a Paradigm
17. Polypharmacy and Drug Interaction
18. Role of Cannabinoids in Pain Management
19. The Future of Pain Pharmacotherapy.

Summary: This definitive practitioner reference and course text comprehensively reviews evidence-based treatments for psychological disorders in children and adolescents. The volume begins with several foundational chapters that guide the reader to think and work as an evidence-based practitioner. Subsequent sections cover treatments for specific clinical problems documented in DSM-5, as well as common presenting issues that do not fit neatly into traditional diagnostic categories. Each well-organized chapter identifies effective psychosocial, pharmacological, and complementary treatments and uses session-by-session examples to illustrate implementation of a recommended approach. -- From publisher's description.

Contents:
Introduction / Mitchell J. Prinstein and Eric A. Youngstrom
Case conceptualization / Kristel Thomassin and John Hunsley
Evidence-based therapist flexibility: making treatments work for clients / Brian C. Chu
Attention-deficit/hyperactivity disorder / Steven W. Evans, Julie Sarno Owens, and Thomas J. Power
Conduct and oppositional disorders / Robert J. McMahon and Paul J. Frick
Depressive disorders / John F. Curry and Allison E. Meyer
Bipolar disorder / Mary A. Fristad and Michelle E. Roley-Roberts
Suicidal and nonsuicidal self-injury / Matthew K. Nock ... [et al.]
Anxiety disorders / Sophie A. Palitz, Jordan P. Davis, and Philip C. Kendall
Obsessive-compulsive disorder / Joshua Kemp and Jennifer B. Freeman
Common issues in infancy and toddlerhood / Juliana Acosta, Daniel M. Bagner, and Alice S. Carter
Autism spectrum disorder / Laura Grofer Klinger and Katerina M. Dudley
Intellectual disability / Johnny L. Matson ... [et al.]
Learning disabilities / Ryan J. McGill and Nadine Ndip
Posttraumatic stress disorder / Annette M. La Greca and BreAnne A. Danzi
Coping and emotion regulation / Bruce E. Compas and Alexandra H. Bettis
Persistent complex bereavement disorder / Julie B. Kaplow, Christopher M. Layne, and Robert S. Pynoos
Child maltreatment / Vicky Veitch Wolfe and Brynn M. Kelly
Substance use problems / Tammy Chung and Rachel L. Bachrach
Early-onset schizophrenia / Aditi Sharma and Jon McClellan
Personality disorders / Francheska Perepletchikova and Donald Nathanson
Eating disorders / James Lock and Lily Osipov
Obesity / Jacqueline F. Hayes ... [et al.]
Sleep problems / Danielle M. Graef and Kelly C. Byars.

Summary: Our understanding of dystonia is advancing rapidly. This comprehensive reference work provides an effective guide to this challenging group of disorders, offering an overview of the current and emerging treatment options for all manifestations. Treatments for the many forms of dystonia differ substantially in pediatrics and adults - both are covered in detail in this book. Approaches include botulinum toxin therapy, deep brain stimulation, oral drug applications, rehabilitation, and behavioral and experimental therapies. Special emphasis is also given to combining different treatment modalities in order to achieve optimal effect. Treatment of Dystonia brings together peer-reviewed articles, written by experts and based on work presented at international conferences. By enabling the physician to select and combine the best therapies, it is an essential resource for neurologists, neurosurgeons and physical therapists.

Contents:

v. 1. Worldwide evidence 1985-1990.

Summary: This book intensively examines the efficacy of plant-derived products that have been used for over a thousand years by practitioners of so-called Traditional Chinese Medicine in the light of recent chemotherapeuticals. The chapters were written by renowned Chinese medical researchers and are supplemented by results obtained in German antiparasitic research projects. Parasites and emerging diseases are a major threat of our time, which is characterized by an enormous increase in the size of the human population and by an unbelievably rapid globalization that has led to the daily transport of millions of humans and containers with goods from one end of the earth to the other. Furthermore the slow but constant global warming offers new opportunities for many agents of diseases to become established in new areas. Therefore it is essential that we develop precautions in order to avoid epidemics or even pandemics in overcrowded megacities or at the large-scale farm animal confinements that are needed to secure a steady flow of food in the crowded regions of the world. Of course intensive research in the field of chemotherapy since 1900 has produced unbelievable breakthroughs in therapies for formerly untreatable and thus deadly diseases. However, a large number of untreatable diseases remain, as well as a constantly growing number of agents of disease that have developed resistances to standard chemical compounds.

Contents:
Introduction ( Heinz Mehlhorn)
Schistosomiasis in China ( Wei Hu)
Clonorchis and Opisthorchis infection and their impact on cancer ( Banchob Sripa)
Angiostrongylus cantonensis in China (Wu Zhongdao, Lv Zhiyue)
Traditonal Chinese treatment methods against schistosomes and other trematodes ( Wu Zhongdao, Su Xi)
Treatment methods of Traditional Chinese Medicine for hydatidosis and other tapeworm infections ( Ye Bin)
Traditonal Chinese treatment methods against nematodes ( Wu Zhongdao, Su Xi)
Toxoplasmosis and traditional chinese medicine (Lv Fangli)
Malaria in China (Ying Wang)
Malaria and traditional Chinese medicine (Xu Wenyue) .- Intestinal protozoan diseases and traditional Chinese medicine (Ma Changling)
Dengue fever and similar vector borne diseases in China (Wu Yu) .- Tsutsugamushi in China (Zheng Xiaoying) .- Leishmaniasis in China (Chen Jianping)
Impact of climate and globalization on parasites (Heinz Mehlhorn)
Conclusions (Heinz Mehlhorn). .

Summary: This unique, comprehensive book provides a much-needed reference on the treatment and management of non-infectious uveitis. Carefully designed, Treatment of Non-infectious Uveitis is the first book of its kind to provide an in-depth, clinically-relevant, expert-driven resource for ophthalmologists focusing on modalities of uveitis treatment, their mechanism of action, dosing, and side effects. Each chapter provides an introduction, mechanism of action, indication, dosage, side effects, and efficacy summaries from clinical trials and other published literature. Topics range from topical treatment, to locally administered therapy including drug-releasing implants, to systemic immunosuppressive treatments both tried and new, as well as surgical management, with each chapter highlighting important practice pearls as well as easy-reference dosing tables, side effects, and lab monitoring pertinent to the agents discussed. The book concludes with a discussion of novel approaches to the treatment of non-infectious uveitis, and special considerations when treating uveitis in the pediatric patient. The majority of patients with non-infectious uveitis are treated by comprehensive ophthalmologists, many of whom are less familiar with established treatment guidelines outlining the role of corticosteroids and immunomodulatory therapy. While the non-specialist, resident, or fellow is sure to benefit from this one-stop guide to uveitis treatment, retina and uveitis specialists alike will also appreciate the practice tips and thorough coverage of this expertly-written reference. Treatment of Non-infectious Uveitis is the ideal reference for all ophthalmologists who seek to improve their understanding of the causes of uveitis and learn how to best treat this condition.

Contents:
Ch 1: Introduction
Ch 2: Topical Therapy in Uveitis
Ch 3: Systemic Corticosteroids in the Treatment of Uveitis
Ch 4: Antimetabolites
Ch 5: T Cell Inhibitors
Ch 6: Alkylating Agents
Ch 7: Biologics Targeting Tumor Necrosis Factor
Ch 8: Biologics Targeting B and T Cell Activation
Ch 9: Targeting Interleukin-6 in Ocular Inflammatory Diseases
Ch 10: Interferons and Intravenous Immunoglobulin
Ch 11: Diagnostic Biopsies in the Management of Uveitis
Ch 12: Therapeutic Vitreoretinal Surgery for Non-infectious Intermediate, Posterior, and Panuveitis
Ch 13: Local Drug Delivery for Non-infectious Uveitis
Ch 14: Novel Approaches to the Treatment of Non-infectious Uveitis
Ch 15: Special Considerations: Treatment of Pediatric Uveitis.

Summary: This book describes new concepts and strategies for the clinical application of non-vitamin K antagonist oral anticoagulants (NOACs) for stroke. Although vitamin K antagonists have traditionally been used for the prevention of stroke, there are some problems associated with their use, such as the risk of intracranial hemorrhage, the need for dietary restrictions, and individual variability. Recently, NOACs have been introduced as alternatives to traditional anticoagulants and are becoming an option for treating stroke patients around the globe. However, their use is not without risk. Each chapter describes the successful use of NOACs for stroke patients and discusses their future impact from various points of view. The book is primarily written for neurosurgeons and neurologists but is also of interest to cardiologists involved in stroke treatment.

Contents:
1.Intracranial Bleeding
2.Severity and Outcomes of Intracerebral Bleeding and Cardiac Cerebral Embolism
3.Influence for Intracranial Bleeding Surgery
4.New Approaches for the Secondary Prevention of Cryptogenic Stroke Using Non-Vitamin K Antagonist Oral Anticoagulants
5.Secondary Prevention of Cerebral Infarct: Verification of Appropriateness in Choices of Anticoagulant by Comparison of Current and previous Treatment Results
6.Putaminal Hemorrhage in Patients with Oral Anticoagulants -Course of Treatment and Results of Endoscopic Evacuation
7.Secondary Prevention of Stroke with Atrial Fibrillation by New Oral Anticoagulants
8.Causes and Outcome in Patients with Cerebral Hemorrhage Using Anticoagulated Drugs.

Summary: This monograph summarizes state of the art knowledge regarding peritoneal surface malignancies, with in-depth description of treatment options and the results achieved to date. It explores the most challenging problems on the basis of the authorsℓ́ℓ very extensive clinical experience and examines the most relevant clinical trials. A comprehensive summary is provided of all phase 2 studies (the only available completed studies) and of ongoing and future phase 3 studies. Particular attention is paid to the results of integrated treatment comprising cytoreduction (peritonectomy) and hyperthermic intraperitoneal chemotherapy (HIPEC). Helpful background information is also included on the definition and clinical assessment of each clinical form. The book, drawing on data from the entire Italian experience as well as world literature, will be an outstanding benchmark for health professionals and researchers.

Contents:
Foreword
Preface 1
Preface 2
Introduction
Part 1 Background
1 Peritoneal surface malignancies: definition
2 Epidemiology: the extent of the problem
3: Intraperitoneal spread: origin and mechanisms
4 Pathology and patterns of molecular biology
5 Classification of intraperitoneal spread
6 Diagnosis and assessment: clinical, radiological, and laparoscopic
Part 2 Treatment
7 Rationale for integrated procedures (combined cytoreduction and HIPEC)
8 Peritonectomy techniques
9 HIPEC techniques
10 The role of surgery
11 The role of systemic chemotherapy
12 Anesthesiology and perioperative management
13 Patient selection for treatment
14 Morbidity and mortality
15 Organizational problems, costs, and data collection
Part 3 Results of integrated treatment
16 Pseudomyxoma peritonei
17 Peritoneal mesothelioma
18 Peritoneal carcinomatosis from gastric cancer
19 Peritoneal carcinomatosis from colorectal cancer
20 Peritoneal carcinomatosis from ovarian and gynecological cancers
21 Other primary peritoneal surface malignancies
22 Peritoneal carcinomatosis from other primary tumors
23 Palliative treatments
Part 4 Perspectives
24 New trials
25 Main topics of discussion and new trends
Part 5 Conclusions.

Summary: Any surgical intervention, elective or acute, may lead to postoperative complications. Moreover, the pertaining approach - laparoscopic or open - will probably not differ in the morbidity rate after surgery. Complications that occur after a surgical intervention can be classified as major or minor. Major complications to the digestive tract after surgery imply in most of cases a leakage of an anastomosis, bleeding in the abdominal cavity or in the tract, the appearance of intraperitoneal abscesses, or surgical site infections and wound dehiscence. These complications, depending on the organ affected, upper GI, HPB tract or colorectal, are associated with high morbidity and mortality. Early suspicion and diagnosis, followed by an early and effective treatment is imperative in order to reduce the morbidity and mortality. Adequate treatment will involve a good coordination of the three disciplines involved in treatment: the surgeon, the intervention radiologist, and the gastroenterologist. Approach of these postoperative complications is changing constantly and these changes are not properly known by general and more specialized digestive surgeons daily involved in the treatment of these diseases. The proposal for this book is to offer a systematic description of the most frequent complications occurring in the three above mentioned parts of the digestive tract. In this way, the reader will have access to a practical book in which every current complication can be easily recognized, along with relevant information as guide for an adequate treatment.

Summary: "Although the benefits of psychological consultation in the pediatric setting are well established, a gap often exists between the demand for these services and funding. We have embarked on our longstanding goal to develop a group-based intervention model for parents of premature infants, adapting our manual of individual trauma-focused cognitive behavioral therapy to help reduce feelings of parental isolation. This book describes a more global approach to psychological consultation in the NICU integrating interventions that begin prior to the infant's conception and extend well beyond the NICU hospitalization. Chapter 1 provides a context and review of the medical aspects of the NICU environment and the neurodevelopmental consequences of prematurity. In Chapter 2 reviews the common psychological reactions of mothers of premature infants, including specific risk factors associated with maternal psychological distress. It also discusses the relationship between parental posttraumatic stress and infant outcomes as it relates to such issues as breastfeeding, maternal-infant interaction, attachment, and infant development. Chapter 3 describes the form and prevalence of symptoms of paternal psychological distress and outline a curriculum for a group-based intervention specifically designed to address fathers' concerns. Chapter 4 addresses developmental care interventions that overlap with interventions more narrowly focused on parental psychological distress. Chapters 5 and 6 describe our intervention model in both the individualand group therapy formats. Chapter 7 addresses vulnerable child syndrome, which is associated with adverse developmental outcomes in children as well as overutilization of health care resources. Application of the trauma model to the concept provides a framework to understand how parental behavior is altered in the context of trauma. Finally, Chapter 8 discusses how to implement a psychological intervention program in the NICU that includes screening the parents of premature infants for symptoms of psychological distress"-- Provided by publisher

Contents:
Medical and Neurodevelopmental Consequences of Prematurity / Krisa P. Van Meurs, Susan R. Hintz
Psychological Adjustment in Mothers of Premature Infants / Richard J. Shaw, Angelica Moreyra, LaTrice L. Dowtin, Sarah M. Horwitz
Postpartum Psychological Experiences of Fathers of Premature Infants / LaTrice L. Dowtin, Tiffany Willis, Daniel Singley
Psychological Interventions in the NICU / Melissa Scala, Soudabeh Givrad, Richard J. Shaw
Individual Trauma-Based Intervention for Mothers of Premature Infants / Emily A. Lilo, Tonyanna C. Borkovi, Angelica Moreyra, Sarah M. Horwitz, Richard J. Shaw
Group-Based Trauma Intervention for Mothers of Premature Infants / Angelica Moreyra, Stephanie Simon, Emily Wharton, Tonyanna C. Borkovi, Richard J. Shaw
Vulnerable Child Syndrome / Margaret K. Hoge, LaTrice L. Dowtin, Sarah M. Horwitz, Richard J. Shaw
Implementing the Evidence-Based Intervention to Address Psychological Distress in Women With Premature Infants / Sarah M. Horwitz, LaTrice L. Dowtin, Emily Lilo.

Contents:
1. The pathophysiology, presentation and diagnostic investigation of pulmonary hypertension
2. Molecular biological aspects, therapeutic targets and new treatment strategies
3. Current treatment strategies, guidelines and new therapies
4. The role of surgery in pulmonary hypertension
5. Putting it all together
Index.

Summary: "Effectively use the latest treatments to manage scars, improving function and quality of life for your patients"-- Provided by publisher.

Contents:
History of Scar Treatment / Omer Ibrahim, Nazanin Saedi, Jeffrey S. Dover, and Kenneth A. Arndt
Basic Science of Scars / Eduardo K. Moioli and Diana Bolotin
Self-Esteem and Psychologic Issues / Abigail Waldman and Murad Alam
Patient Selection and Counseling / Mara C. Weinstein Velez, Nazanin Saedi, Jeffrey S. Dover and Kenneth A. Arndt
Burn Rehabilitation : Range of Motion and Pain Following Acute Burn Injury / Rodney K. Chan
Treatment Algorithm : What, When? / Murad Alam
Surgical Correction of the Late Effects of Burns / Rodney K. Chan
Surgical Scar Revision / J Regan Thomas and Katherine Hicks
Dermabrasion / Eric W. Cerrati and J. Regan Thomas
Fractional Resurfacing of Traumatic and Burn Scars / Shilpi Khetarpal, Elizabeth Jones, Kenneth A. Arndt, Jeffrey S. Dover and Nazanin Saedi
Antimetabolites And Antimitotic Drugs In The Treatment Of Keloid And Hypertrophic Scars / Abigail Waldman and Murad Alam
Laser-Assisted Drug Delivery for Scars / Jill S. Waibel, Ashley Rudnick, and Dorene Niv
Autologous Fat Grafting in the Reconstruction and Rejuvenation of Traumatic Scars / Isaac E. Schwartz, Curtis W. Gabal, and Jose E. Barrera
Stem Cell Transfer / Jill S. Waibel, Alexander Daoud, Ashley Rudnick, and Carly Wyler
Vascular Lasers and Lights For The Treatment of Scars / Brian A. Raphael, Nazanin Saedi, Kenneth A. Arndt, Jeffrey S. Dover
Practical Cases / Jordan T. Blough, Arun K. Gosain, and John Y. S. Kim
Future of Scar Management / Michael M. Vu, Robert D. Galiano, and John Y. S. Kim.

Summary: As the population continues to age worldwide, spinal disease will become more prevalent in the elderly population. The treatment of spinal disease requires an individual approach encorporating best practices. Optimal management in the elderly may differ from younger patients due to increased comorbidities, decreased bone health, and a higher risk of perioperative morbidity and mortality. While more and more elderly patients will require evaluation and management of their spinal disease, most modern books discuss operative and nonoperative management based upon disease process. Techniques and approaches are described for a specific pathology, and are usually tailored for a young or middle aged patient. Treatment of Spine Disease in the Elderly: Cutting Edge Techniques and Technologies is designed to address this gap in today's literature by expressly addressing spinal conditions in the elderly and current advanced techniques and technologies for treating their spinal disease. It will be intended as a resource for the beginning to the advanced surgeon and practitioner whom undertakes treatment of patients in this age group. .

Contents:
Intro
Foreword
Elderly Specific Considerations in Spine Disease
Trauma
Tumor
Adult Deformity
Osteoporosis
References
Contents
Part I: Special Perioperative Considerations in the Elderly
Chapter 1: Bone Health, Advances in Assessment and Treatment
Introduction
Identification of Patients at Risk for Postoperative Complications
Dual-Energy X-ray Absorptiometry (DXA)
Computed Tomography (CT)-Based Techniques
Trabecular Bone Score (TBS)
High-Resolution Peripheral QCT (HR-pQCT)
Optimization of Bone Strength Perioperatively
Bisphosphonates
Anabolic Agents: Teriparatide
Anabolic Agents: Abaloparatide
Combination Therapy
Conclusion
References
Chapter 2: Antithrombotic Management in Spine Surgery in the Elderly
Introduction
Preoperative Antithrombotic Therapy
Antithrombotic Agent Classes
Antiplatelets
Aspirin (Acetylsalicylic Acid, ASA)
Clopidogrel and Other P2Y12 Receptor Antagonists
Oral Anticoagulants
Warfarin
Direct Oral Anticoagulants (DOACs)
Heparin Compounds
Unfractionated Heparin (UFH)
Low Molecular Weight Heparin (LMWH)
Fondaparinux
Bridging Anticoagulation
Intraoperative Anticoagulation
Postoperative Antithrombotic Therapy
Antiplatelets
Aspirin (Acetylsalicylic Acid, ASA)
Clopidogrel and Other P2Y12 Receptor Antagonists
Oral Anticoagulants
Warfarin
Direct Oral Anticoagulants (DOACs)
Heparin Compounds
Unfractionated Heparin and LMWH
Antithrombotic Management in the Emergent Setting
Antiplatelets
Aspirin
Clopidogrel
Oral Anticoagulants
Warfarin
DOACs
Heparin Compounds
Unfractionated Heparin
LMWH
Fondaparinux
Special Considerations
Changes in Body Composition
Pharmacokinetics
Absorption
Volume of Distribution
Protein Binding
Clearance. Hepatic Impairment
Renal Impairment
Fall Risk
Diet
Polypharmacy
Future Directions
References
Chapter 3: Managing Multiple Medical Comorbidities
Pre-operative Risk Stratification and Communication of Risk
Geriatric-Specific Risk Factors
Age as a Risk Factor
Obesity
Management of Diabetes
Cardiac and Pulmonary Disease
Venous Thromboembolism
Anemia
Delirium
Pain Management Before and After Surgery
Smoking, Alcohol, and Substance Use
Post-operative Disposition
Conclusions
Bibliography
Chapter 4: Anesthetic Concerns for Spinal Surgery in the Elderly
Introduction
Age-Related Physiologic Changes
Central Nervous System
Cardiovascular
Respiratory
Renal
Gastrointestinal
Musculoskeletal and Cutaneous
Preanesthetic Consultation
Frailty
Prehabilitation
Cognition and Dementia
Medication Management
Intraoperative Management
Anesthetic Techniques: General and Regional Anesthesia and Monitored Anesthesia Care
Depth of Sedation
Hemodynamic Perfusion Monitoring
Intraoperative Neurophysiological Monitoring
Postoperative Management
Screening for Delirium
Postoperative Cognitive Dysfunction
Management Strategies
Conclusions
References
Chapter 5: Spinal Prehab/Rehab in the Elderly
Early Postoperative Rehabilitation
Conclusion
References
Chapter 6: ERAS and Spine Surgery
Introduction
Rationale for the Use of ERAS in Spinal Surgery
ERAS Components
Preoperative Period
Intraoperative Period
Postoperative Period
Outcomes by Type of Spine Surgery
Surgery by Anatomical Level
Minimally Invasive Surgery
Deformity Surgery
Tumor Surgery
Outcomes in Elderly Patients
ERAS Implementation
Conclusion
References
Part II: Spine Disease in the Elderly. Chapter 7: Surgical Treatment of Cervical Spondylotic Myelopathy
Introduction
Pathophysiology
Elderly Perioperative Considerations
Surgical Management
Ventral Approaches
ACDF
Corpectomy
Dorsal Approaches
Laminectomy
Laminectomy and Fusion
Laminoplasty
Combined Approach
Complications
Age
Approach
Common Complications
Future Research
Conclusions
References
Chapter 8: Atlantoaxial Fracture Management
Introduction
Anatomy and Mechanical Properties of the Atlantoaxial Complex
Epidemiology
Odontoid Fractures
Diagnosis
Imaging
Morbidity and Mortality
Management
External Immobilization
Operative Management
Fractures of the Atlas
Diagnosis and Treatment
C1-2 Dislocation and Subluxation
Imaging and Diagnosis
Treatment
Hangman's Fractures
The Modified Effendi Classification System
Diagnosis
Management and Operative Technique
Conclusions
References
Chapter 9: MIS Cervical Approaches in the Elderly
Introduction
MIS Posterior Fusion via Facet Joint Arthrodesis
MIS Posterior Cervical Foraminotomy (PCF)
Tubular Cervical Unilateral Laminotomy for Bilateral Decompression
Conclusion
References
Chapter 10: Subaxial Spinal Trauma
Introduction
Epidemiology
Etiology
Diagnosis
Classification
Treatment
Outcomes, Mortality and Complications
References
Chapter 11: Anterior vs. Posterior Cervical Approaches for the Elderly
Introduction
Patient Selection
Cervical Spine Alignment
Number of Levels Requiring Decompression
Approach-Related Complications to Consider
C5, C8, and T1 Nerve Root Injuries
Dysphagia
Dysphonia
Wound Complications
Other Considerations
OPLL
Pseudarthrosis
Revision Surgery
Anterior Cervical Approaches. Anterior Cervical Discectomy and Fusion (ACDF)
Other Surgical Considerations
Anterior Cervical Corpectomy and Fusion (ACCF)
Other Surgical Considerations
Anterior Cervical Hemi-Corpectomy and Fusion (ACHCF)
Cervical Disc Arthroplasty (CDA)
Posterior Cervical Approaches
Laminectomy and Fusion
Laminoplasty
Laminoplasty Versus ACDF
Laminoplasty Versus Laminectomy and Fusion
Conclusion
References
Chapter 12: Cervical Spine Disease in Elderly Patients with Ankylosing Spondylitis
Background and Etiology
Epidemiology and Risk Factors
Medical Treatments for AS
Cervical Spine Fracture in the Elderly
Cervical Deformity in the Elderly
Navigation Technology for the Surgical Treatment of Ankylosing Spondylitis
Nanomedicine: A Novel Treatment
AI and Technological Modeling
References
Chapter 13: Cervical Spine Deformity in the Elderly
Background
Cervical Spinal Deformity Development in the Elderly
Evaluation for Surgery in Cervical Spine Deformity in the Elderly
Initial Evaluation
Radiographic Evaluation
Surgical Planning
Algorithmic Approach to Cervical Spine Deformity Correction
Fixed Deformity Without Ankylosis
Fixed Deformity with Anterior Ankylosis
Fixed Deformity with Posterior Ankylosis
Fixed Deformity with Circumferentially Fused Cervicothoracic Junction
Flexible Deformity with Mild Kyphosis
Flexible Deformity with Moderate Kyphosis
Flexible Deformity with Severe Kyphosis
Radiographic Success After Cervical Spine Deformity Correction in the Elderly
Complications After Cervical Spine Deformity Correction in the Elderly
Conclusion
References
Chapter 14: Spinal Cord Injury in the Elderly Population
Introduction
Central Cord Syndrome. Spinal Trauma Associated with SCI: Odontoid Fracture, Penetrating Injury, and Fracture Dislocation
Odontoid Fractures
Penetrating Injury
Thoracolumbar Fracture/Dislocation Associated with SCI
Medical Management
Surgical Management
Outcomes
Experimental Treatments
Conclusion
References
Chapter 15: Cervical Spinal Oncology
Introduction
Frailty in the Elderly Spine Oncology Patient
Primary Spine Tumors
Tumors of the Vertebral Column
Tumors of the Spinal Cord and Meninges
Intradural Extramedullary Lesions
Intradural Intramedullary (Intrinsic) Lesions
Metastatic Lesions
Goals of Surgery
Who Is a Surgical Candidate?
Minimally Invasive Surgical Techniques and Alternatives for Frail Patients
Nonsurgical Alternatives
Conclusion
References
Part III: Thoracolumbar Disease in the Elderly
Chapter 16: Management of Spondylolisthesis in the Elderly Population
Introduction
Diagnosis
Nonsurgical Treatment
Physical Therapy
Medications and Injections
Conservative vs. Surgical Treatment
Surgical Treatment
Indications for Surgical Treatment
Overview of Surgical Alternatives for Lumbar Spondylolisthesis
Outcomes of Surgical Treatment
Complications
Conclusion
References
Chapter 17: Sagittal Plane Deformity Considerations in the Elderly
Pathophysiology
Radiographic Parameters
Pelvic Parameters
Pelvic Incidence
Pelvic Tilt
Sacral Slope
Regional Spine Alignment
Relationship of Lumbar Lordosis to Pelvic Incidence
Roussouly Spine Types
Global Spinal Alignment
Radiographic Parameters and Patient-Reported Outcomes
Age-Adjusted Radiographic Parameters
Surgical Correction of Adult Spinal Deformity in the Elderly
Conclusion
References
Chapter 18: Revision Surgery in the Elderly
Introduction.

Summary: This is a timely and informative updated volume for all health care providers challenged with helping patients manage weight. Similar to the well-reviewed first edition, Treatment of the Obese Patient, Second Edition is directed toward individuals who wish to read further about targeted topics, rather than find an introduction to the field. This second edition again provides insights into recent scientific advances in obesity research and provides the most up-to-date instruction about current treatment issues and strategies for both adults and children. An essential, practical text that sorts, synthesizes, and interprets the latest information on obesity-related topics, Treatment of the Obese Patient, Second Edition, is an essential resource for clinical endocrinologists and other health care providers across a broad spectrum of specialties.

Contents:
Genetics of Obesity
Reward, Reinforcement and Impulsivity in Obesity
Neuroregulation of Body Weight: Lessons from Animal Models
Gut Hormones and the Regulation of Body Weight
Non Alcoholic Steatohepatitis and the Complications of Obesity
Critical Importance of the Perinatal Period in the Development of Obesity
Body Composition in Obesity
Gut Microbiome and Obesity
Shortened Sleep Time and Obesity
Adaptive Responses to Weight Loss
Recent Developments in the Epidemiology of Obesity
Assessment of the Obese Patient
Behavioral Strategies in Weight Management
Dietary Modification as a Weight Management Strategy
Physical Activity as a Weight Management Strategy
Weight Loss Drugs, Present and Future
Surgical Approaches and Outcomes
Pre and Post-Operative Management of the Bariatric Surgical Patient
Early Findings from the LOOK Ahead Trial
Treatment of Obesity in the Primary Care Clinic
Assessment of the Obese Child
Treatment of the Obese Adolescent.

Contents:
Sleep and its regulation
Behavioral regulation of sleep : the role of arousal
Other sleep disorders
The impact of comorbid disorders on sleep and insomnia
Assessment of insomnia
Behavioral components of CBT-I : Part I
Behavioral components of CBT-I : Part II
Addressing sleep-related cognitions
Case conceptualization and treatment planning
Case example 1 : Sophie
Case example 2 : Sam
General delivery issues.

Summary: "Schizophrenia is often associated with an inadequate response to pharmacological and non-pharmacological treatments. How to treat patients who have an unsatisfactory response to anti-psychotics, including clozapine - which is unequivocally the most powerful antipsychotic medication for this recalcitrant population - remains a clinical conundrum. A range of adjunctive medications have been tried with mixed results; there has also been renewed interest in the role of neuromodulatory strategies, electroconvulsive therapy, and cognitive and vocational approaches. Perhaps a bright spot for the future lies in the evolution of pharmacogenetic approaches for individualized care. In this book, leading experts from Europe, Australia and the Americas provide a timely appraisal of treatments for the most severely ill schizophrenia patients. This clinically focused book is informed by the latest research on the neurobiology and treatment of schizophrenia. It is comprehensive in scope, covering current treatment options, various add-on approaches, and a range of psychosocial treatments. The contributors are respected experts who have combined their clinical experience with cutting-edge research to provide readers with authoritative information on fundamental aspects of clinical care for schizophrenia."--Publisher's website.

Summary: This book offers a highly informative guide to treating unexplained infertility and recurrent miscarriage (RM). In particular, it provides detailed treatment strategies for infertility or RM derived from uterine circumstance such as chronic endometritis and perturbation of endometrial decidualization, as well as maternal immunological rejection of an embryo as semi-allograft. Unexplained infertility refers to those types that cannot be detected by the general screening test. The causes are sometimes detected in the course of treatment with assisted reproductive technology including IVF. However, some unexplained infertility is intractable even after intracytoplasmic sperm injection or repeated implantation of morphologically suitable embryos. Patients with unexplained RM also have a high likelihood of undetectable risk factors of miscarriage. As a result, gynecologists often repeatedly provide these couples with general treatments for infertility and miscarriage or even discontinue treatment because they cannot detect the reason, which places serious financial, physical and mental burdens on the couples affected. This book offers gynecologists essential insights into the pathological condition of unexplained infertility and RM, equipping them to identify it, explain it to patients, and consider further examinations and more aggressive fertility treatments.

Contents:
Introduction / Jonathan S Abramowitz, Eric A Storch, Dean McKay
Cognitive Behavioral Therapy / Jesse R Cougle, Melanie A Hom, Natalie L Matheny
Fears and Specific Phobias / Maysa M Kaskas, Paige M Ryan, Thompson E Davis
Panic Disorder and Agoraphobia / Lily A Brown, Michelle G Craske
The Nature and Treatment of Social Anxiety / Joseph K Carpenter, Joshua Curtiss, Stefan G Hofmann
The Nature and Treatment of Obsessions and Compulsions / Jonathan S Abramowitz
Hoarding Disorder / Tina L Mayes, Catherine R Ayers
Mechanisms and Treatment of Generalized Anxiety Disorder / Michelle G Newman, Ki Eun Shin, Lucas S LaFreniere
Empirically Supported Conceptualizations and Treatments of Post-traumatic Stress Disorder / Jonathan D Green, Brian P Marx, Terence M Keane
Post-traumatic Stress Disorder Treatment Effects and Underlying Mechanisms of Change / Lori A Zoellner, Alissa B Jerud, Elizabeth H Marks, Natalia M Garcia
Persistent Depressive Disorder (Dysthymia) and Its Treatment / James P McCullough, Sarah W Clark
Matching Empirically Supported Therapies to Treatment Targets in Bipolar Disorder / Anna Meter, Eric Youngstrom
Schizophrenia and Severe Mental Illness / Dennis R Combs, Kim T Mueser
Anorexia Nervosa / Lauren Breithaupt, Sarah Fischer, Joanna Marino, Diana Gaydusek
Bulimia Nervosa / Sarah Fischer, Kendra Davis, Lauren Breithaupt
Alcohol Use Disorders / Barbara S McCrady
Cognitive Behavior Therapy for Insomnia / Shelby Harris, Eleanor McGlinchey
Psychological Approaches for Low Sexual Arousal / Charmaine Borg, Peter J Jong
Problems of Mood Dysregulation / Shannon Sauer-Zavala, Laren R Conklin
Mechanisms of Treatments for Trichotillomania (Hair Pulling Disorder) / Elle Brennan, Sarah K Francazio, Yolanda E Murphy, Christopher A Flessner
Body-Focused Repetitive Behavior / Christine A Conelea, Hannah E Frank, Michael R Walther
Non-suicidal Self-injury / Emily H Brackman, Margaret S Andover
Severe Health Anxiety in the Somatic Symptom and Related Disorders / Erik Hedman, Erland Axelsson
Borderline Personality Disorder / Shireen L Rizvi, Marget C Thomas
Paraphilias / William T O'Donohue, Julie Kahler, Natalie Bennett, Olga Cirlugea, Lorraine Benuto
Treating Relationship Distress / Christine Paprocki, Donald H Baucom
Acceptance and Commitment Therapy / Michael E Levin, James D Herbert, Evan M Forman
Transdiagnostic Approaches to Cognitive Behavioral Therapy for Emotional Disorders / Todd J Farchione, Laren R Conklin, Jacqueline R Bullis
Neural Network Models as Explanatory Frameworks of Psychopathology and Its Treatment / Warren W Tryon, Jonathan Hoffman, Dean McKay
Disgust in Psychopathology / Rachel Ojserkis, William Taboas, Dean McKay
Temperament in Youth Internalizing Disorders / Helen F Dodd, Jennifer L Hudson, Ronald M Rapee
Oppositionality and Functionality in Youth Externalizing Disorders / Randi Bennett, Samantha Adelsberg, Amy K Roy
Early Childhood Externalizing Behavior Problems and Parent Training Interventions / Daniel M Bagner, Dainelys Garcia, Nicole E Barroso.

Summary: Dothistroma pini changed New Zealand commercial forestry dramatically. Tree breeding became concentrated on a very few species and development of selection methods and breeding strategies changed in response to the new challenges. Tree-Breeding and Genetics in New Zealand provides a critical historical account of the work on provenance research and tree breeding, often with the wisdom of hindsight, and it tracks the development of breeding strategy, especially for P. radiata, Douglas-fir and the most important eucalypt species, E. regnans, E. fastigata and E. nitens. The book is a compendium of abstracts and summaries of all publications and reports on tree improvement in New Zealand since the early 1950s, with added critical comment by the author on much of the work. It is intended for other tree breeders internationally, for interested NZ foresters and for graduate students studying genetics and tree breeding.

Contents:
Foreword
The influence of Ib Thulin
Species and provenance testing Eastern USA species
Species and provenance testing European and Japanese species
Species and provenance testing western USA species
Douglas-fir provenance and breeding
Finale: Species and provenance testing of conifers
Experiment design in provenance and progeny trials
Eucalypt (hardwood) species and provenance research, and breeding programs
Finale Eucalypts
Cupressus and other conifers
Clonal forestry
Breeding theory
Radiata breeding
Breeding Strategy
Conclusions
The Future of Forest Tree Improvement in New Zealand
Appendix
References.

Summary: Bring your practice fully up to date with the most effective and innovative techniques in aesthetic plastic surgery. Trends and Techniques: Aesthetic Plastic Surgery covers today's sought-after procedures- from male-specific aesthetic techniques to liposuction technologies and vaginal rejuvenation-all innovative new procedures that will greatly benefit your patients' quality of life. In this outstanding resource, you'll learn not only from Dr. Lina Triana, but also from other internationally recognized aesthetic surgeons in plastic surgery, facial plastic surgery, oral and maxillofacial surgery, and dermatology. Chapters cover high-demand procedures such as facelifts and lip enhancements, liposuction and J plasma, mamopexy after breast implant removal, hoodplasty, vaginal tightening, scrotal lift, penis enhancement, and more. Offers expert commentary from world-renowned surgeons, including surgical tips and tricks that help you achieve the best outcomes and avoid complications. Discusses gender differences in body definition and non-surgical procedures, as well as marketing in the plastic surgeon's practice. Allows today's cosmetic surgeons to offer top procedures with optimal outcomes, enabling increased patient satisfaction and repeat consultation. Enhanced eBook version included with purchase. Your enhanced eBook allows you to access all of the text, figures, and references from the book on a variety of devices.

Summary: This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammation, or the vulnerability of cancer patients to bacterial meningitis, the infection that remains underdiagnosed due to limited expression of symptoms. The book also covers other key topics, such as the psychological care of lung cancer patients; difficulties in the diagnosis of diffuse axonal injury in traumatic brain injury - a disorder with a poor prognosis and high mortality rate; and the virological aspects of seasonal influenza epidemic outbreaks - a perennial modern scourge. Further, it addresses recent developments in targeted drug delivery from titanium implants and a novel integrated thermal approach to rehabilitation of neurodegeneration-related disabilities. Featuring the latest interdisciplinary trends in biomedicine, this book connects research, theory and practice to help alleviate suffering caused by a variety of diseases. It is a resource for medical professionals, including academics, practitioners and all allied healthcare workers. -- Provided by publisher.

Contents:
Targeted drug delivery from titanium implants : a review of challenges and approaches / Anweha Barik, Nishant Chakravorty
Reliability of magnetic resonance tractography in predicting early clinical improvements in patients with diffuse axonal injury grade III / Sunil Munakomi, Deepak Poudel, Sangam Shrestha
Integrated thermal rehabilitation : a new therapeutic approach for disabilities / Giovanni Barassi, Esteban Obrero-Gaitan, Giuseppe Irace, Matteo Crudeli, Giovanni Campobasso, Francesco Palano et al.
Cat allergy as a source intensification of atopic dermatitis in adult patients / Andrzej Kazimierz Jaworek, Krystyna Szafraniec, Magdalena Jaworek, Zbigniew Doniec, Adam Zalewski, Ryszard Kurzawa et al.
Clinical course and outcome of community-acquired bacterial meningitis in cancer patients / ClMarcin Paciorek, Agnieszka Bednarska, Dominika Krogulec, Michał Makowiecki, Justyna D. Kowalska, Dominik Bursa et al.
Influence of coping strategy on perception of anxiety and depression in patients with non-small cell lung cancer / Beata Jankowska-Polańska, Jacek Polański, Mariusz Chabowski, Joanna Rosińczuk, Grzegorz Mazur
Inflammatory markers during continuous high cutoff hemodialysis in patients with septic shock and acute kidney injury / Grzegorz Kade, Sławomir Literacki, Agnieszka Rzeszotarska, Stanisław Niemczyk, Arkadiusz Lubas
Body composition and biochemical markers of nutrition in non-dialysis-dependent chronic kidney disease patients / Aleksandra Rymarz, Maria Zajbt, Anna Jeznach-Steinhagen, Agnieszka Woźniak-Kosek, Stanisław Niemczyk Biocompatibility of hemodialysis / Małgorzata Gomółka, Longin Niemczyk, Katarzyna Szamotulska, Magdalena Mossakowska, Jerzy Smoszna, Aleksandra Rymarz et al.
Decreasing vaccination coverage against hepatitis B and tuberculosis in newborns / Aneta Nitsch-Osuch, Beata Pawlus, Maria Pawlak, Ernest Kuchar
Virological and epidemiological situation in the influenza epidemic seasons 2016/2017 and 2017/2018 in Poland / E. Hallmann-Szelińska, K. Łuniewska, K. Szymański, D. Kowalczyk, R. Sałamatin, A. Masny et al.
Epidemic influenza seasons from 2008 to 2018 in Poland : a focused review of virological characteristics / Sainjargal Byambasuren, Iwona Paradowska-Stankiewicz, Lidia B. Brydak.

Contents:
Stroke Surgery.- Endovascular treatment
Management of Intracranial Aneurysms, Subarachnoid Haemorrhage, Arteriovenous Malformations, Cerebral Hemorrhage.- Cerebral Revasculization
Cerebrovascular Imaging.

Summary: This is an open access proceeding book of 9th European-Japanese Cerebrovascular Congress at Milan 2018. Since many experts from Europe and Japan had very important and fruitful discussion on the management of Cerebrovascular diseases, the proceeding book is very attractive for the physician and scientists of the area.

Contents:
1 History of the European-Japanese Cerebrovascular Congress
PART I INTRACRANIAL ANEURYSMS
2 When is Diagnostic Subtraction Angiography Indicated Before Clipping of Unruptured and Ruptured Intracranial Aneurysms? An International Survey of Current Practice
3 Current Strategies in the Treatment of Intracranial Large and Giant Aneurysms
4 Computational Fluid Dynamics for Cerebral Aneurysms in Clinical Settings
5 Microneurosurgical Management of Posterior Inferior Cerebellar Artery Aneurysms: Results of a Consecutive Series
6 Posterior Circulation Aneurysms: A Critical Appraisal of a Surgical Series in Endovascular Era
7 Microneurosurgery for Paraclinoid Aneurysms in the Context of Flow Diverters Revolution
PART II CEREBRAL REVASCULARIZATION
8 Characteristic Pattern of the Cerebral Hemodynamic Changes in the Acute Stage After Combined Revascularization Surgery for Adult Moyamoya Disease: N-isopropyl-p-[123I] iodoamphetamine Single-Photon Emission Computed Tomography Study
9 Outcomes of Balloon Angioplasty and Stenting for Symptomatic Intracranial Atherosclerotic Stenosis At a High Volume Center
PART III ARTERIOVENOUS MALFORMATIONS AND DURAL ARTERIOVENOUS FISTULAS
10 Living with a Brain AVM: A Quality of Life Assessment
11 Complications in AVM Surgery
12 Surgical Simulation with Three-Dimensional Fusion Images in Patients with Arteriovenous Malformation
13 Surgical Treatment of Unruptured Brain AVMs: Short and Long Term Results
14 Maximum Nidus Depth as a Risk Factor of Surgical Morbidity in Eloquent Brain Arteriovenous Malformations
15 Brain Arteriovenous Malformations Classifications: A Surgical Point of View
16 The Pre-Operative Functional Downgrading of Brain AVMs
17 Intracranial Dural Arteriovenous Fistulas - The Sinus and Non Sinus Concept
18 Complications of Endovascular Treatment of Intracranial Dural Arteriovenous Fistulas
19 Spinal Dural AVFs, Classifications and Advanced Imaging
PART IV MISCELLANEOUS
20 Intra-Operative BOLD-fMRI Cerebrovascular Reactivity Assessment
21 The Hybrid Neurosurgeon -The Japanese Experience.

Summary: This book provides an overview on the basics in insect molecular biology and presents the most recent developments in several fields such as insect genomics and proteomics, insect pathology and applications of insect derived compounds in modern research. The book aims to provide a common platform for the molecular entomologist to stimulate further research in insect molecular biology and biotechnology. Insects are one of the most versatile groups of the animal kingdom. Due to their large population sizes and adaptability since long they attract researchers' interest as efficient resource for agricultural and biotechnological purposes. Several economically important insects such as Silkworms, Honey Bee, Lac and Drosophila or Termites were established as invertebrate model organisms. Starting with the era of genetic engineering, a broad range of molecular and genetic tools have been developed to study the molecular biology of these insects in detail and thus opened up a new horizon for multidisciplinary research. Nowadays, insect derived products are widely used in biomedical and biotechnology industries. The book targets researchers from both academia and industry, professors and graduate students working in molecular biology, biotechnology and entomology.

Contents:
Intro; Preface; Acknowledgements; Contents; About the Editors; Part I: Insect Genomics and Proteomics;
1: Molecular Marker-Assisted Selection Breeding in Silkworm, Bombyx mori; 1.1 Introduction; 1.2 Quantitative Trait Locus (QTL); 1.3 Reverse Genetics; 1.4 Genome Annotation; 1.5 Extraction of DNA; 1.6 Cutting DNA into Small Fragments; 1.7 DNA Sequencing; 1.7.1 The Maxam-Gilbert technique; 1.7.2 The Sanger dideoxy DNA sequencing technique; 1.7.3 Pyrosequencing; 1.7.4 Shotgun Sequencing; 1.7.5 Whole-Genome Shotgun Sequencing; 1.8 Gene Libraries; 1.9 Preparation of cDNA. 1.10 DNA Fingerprinting (or Genetic Fingerprinting or DNA Testing or DNA Typing or DNA Profiling)1.11 Protection of DNA Fragments; 1.12 Contig; 1.13 Expressed Sequence Tag (EST); 1.14 Transposons; 1.15 Cloning; 1.15.1 Identification of Transformed Cell; 1.16 DNA Probe; 1.17 Blotting; 1.17.1 The Southern Blot; 1.17.2 The Northern Blot; 1.17.3 The Western Blot (Immunoblot); 1.17.3.1 Tissue Preparation; 1.17.3.2 Protein Sample Preparation; 1.17.3.3 Separation of Protein Fractions; 1.17.3.4 Two-Step Method; 1.17.3.5 One-Step Method; 1.17.3.6 Colorimetric Detection. 1.17.3.7 Chemiluminescence1.17.3.8 Radioactive Detection; 1.17.3.9 Fluorescent Detection; 1.18 Polymorphism in Repeated Sequences; 1.19 DNA Markers; 1.19.1 Types of Markers; 1.19.1.1 RFLP; 1.19.1.2 PCR Based Markers; RAPD; AFLP; Minisatellite; Microsatellites: STR, SSR, or SSLPs; Development of Microsatellite Primers; SNP (Single Nucleotide Polymorphism); STS (Sequence Tagged Sites); SCAR (Sequence Characterized Amplified Region); CAPS (Cleaved Amplified Polymorphic Sequence); ISSRs (Inter-Simple Sequence Repeats); DArT (Diversity Array Technology); LCN-DNA (Low Copy Number DNA). 1.20 Markers in Silkworm, Bombyx moriReferences;
2: Molecular, Neuronal, and Behavioral Mechanism of Communication Among Insect Species: A Review; 2.1 Introduction; 2.2 Necessity of Communication; 2.3 Types of Communications Among Insect Species; 2.3.1 Visual Communication; 2.3.2 Tactile and Behavioral Communication; 2.3.3 Acoustic Communication; 2.3.4 Chemical Communication; 2.4 Insect Hydrocarbons and Chemical Communication; 2.5 Neuronal Basis of Insect Communication; 2.6 Molecular and Biochemical Basis of Chemical Communication. 2.7 Pheromones in Communication Among Insect Partners2.8 Molecular Mechanism of Odor Reception in Insects; 2.9 Pheromone Detection by Olfactory Systems; 2.10 Behavioral Mechanism of Communication Among Insect Species; 2.11 Honeybee Dancing; 2.12 Magnetic Orientation; References;
3: Monocyclic Aromatic Hydrocarbons (MAHs) Induced Toxicity in Drosophila: How Close How Far?; 3.1 Introduction; 3.2 Benzene; 3.3 Xylene, Toluene and Styrene; 3.4 Cytotoxicity Induced by Individual of Benzene, Toluene and Xylene on Drosophila.

Summary: This book covers topical issues in neurovascular surgery, and in particular the management of intracranial aneurysms, arteriovenous malformations, and cavernomas, current trends in cerebral revascularization, and new concepts in cerebrovascular imaging. The contents reflect the continuing developments in interventions in cerebrovascular disorders as a result of progress in neuroimaging, evolution of pathophysiological concepts, new clinical trials, and technological innovations. The chapters are all written by acknowledged experts from across the world, and comprise original papers presented at the 6th European Japanese Stroke Surgery Conference, held in June 2012 in Utrecht, The Netherlands. The book will be of value to all who are interested in the latest developments in the field and offers fascinating insights into varied perspectives and techniques.

Contents:
INTRACRANIAL ANEURYSMS: Surgical decision-making for managing complex intracranial aneurysms
Recurrent and incompletely treated aneurysms
The mini supra-orbital approach for cerebral aneurysm of the anterior portion of the circle of Willis
Surgical exclusion of unruptured middle cerebral artery aneurysms: experience on 126 cases
Progress in the treatment of unruptured aneurysms
Distal Basilar Artery Aneurysms: Conditions for the safe and secure clipping
Role of bypass surgery and balloon occlusion test for the endovascular management of fusiform dissecting aneurysms. Report of two cases
Analysis of combined coiling and neuroendoscopy in the treatment of intraventricular hemorrhage due to ruptured aneurysm
Intracranial hypertension in subarachnoid haemorrhage: outcome after decompressive craniectomy. CEREBRAL REVASCULARIZATION:Selective targeted cerebral revascularization via microscope integrated Indocyanine green videoangiography technology
Combined bypass technique for contemporary revascularization of unilateral MCA and bilateral frontal territories in moyamoya vasculopathy
How I do it: Non Occlusive High Flow Bypass Surgery
The role of MCA-STA bypass surgery after COSS and JET
The European point of view.

Summary: This book takes readers on a journey around the world and through time, accompanied by a modern neurosurgeon who reviews historical techniques and instruments used for cranial opening. The author draws on original medical and surgical books to provide a comprehensive history of these techniques and tools. To complement the general overview and offer readers a more 'hands-on' sense of context and atmosphere, extensive historical references, stories, media news and illustrative cases have been included for each historical and geographical scenario. In addition, original illustrations and plates of these archaic instruments and techniques are supplied. Neurosurgical surgeons, nurses, technicians, medical historiographers, paleo-pathologists and researchers interested in surgical techniques for cranial opening will find the volume a valuable guide, intended to increase the historical and cultural awareness of this core topic in neurological surgery. -- Provided by publisher.

Contents:
​TREPANATION, TREPHINING AND CRANIOTOMY
History and Stories PART I. INTRODUCTION. TREPAN, TREPHINE AND CRANIOTOMYChapter 1.An overview.Chapter 2.Semantic features. PART II. MAGIC TIMES. TREPANATION IN PRIMITIVE CULTURESChapter 3.Facts and myths of primitive trepanations.Chapter 4.Techniques and tools for primitive trepanations.Chapter 5.The question of survival in primitive trepanations.Chapter 6.Historical and geographical areas of primitive trepanations.\ PART III. ORIGINS. TREPANATION IN CLASSICAL MEDITERRANEAN CULTURESChapter 7.The first documented reports of the surgical trepanations appear in the Corpus Hippocraticum. Greco-Roman trepanations.Chapter 8.Greco-Roman surgical instruments for trepanations.Chapter 9.Greco-Roman techniques and indications of trepanation. PART IV. DARK TIMES. TREPANATION IN THE MIDDLE AGESChapter 10.Cranial trepanation during the Middle Ages. PART V. LIGHTS AND SHADOWS. TREPANATION AND TREPHINE IN MODERN EUROPEAN CULTURESChapter 11.Surgical instruments for trepanation and trephine in Modern Age.Chapter 12.State -of-the-art' of the trepanation during the sixteenth-seventeenth centuries.Chapter 13.Relevant French, Italian and Spanish surgeons in trepanation over the sixteenth and seventeenth centuries.Chapter 14.Other relevant European surgeons in trepanation over the sixteenth and seventeenth centuries.Chapter 15.Trepanation out of Europe: New World and Japan.Chapter 16.Trepanation during the eighteenth century. To trepan or not to trepan.Chapter 17.Trepanation during the nineteenth century.Chapter 18.Trepanation at war times. Napoleonic Wars and North American Civil War.Chapter 19.The question of the high mortality of trepanation and trephine.Chapter 20.Evolution of the surgical technique of the trepanation and trephine in Modern Age.Chapter 21.Evolution of the surgical instruments for trepanation and trephine in Modern Age.Chapter 22.Evolution of the indications for trepanation and trephine in Modern Age.Chapter 23.'State-of the-art' of the cranial opening in the second half of the nineteenth century.Chapter 24.Trepanation and trephine in Modern Age: Illustrative cases. PART VI. MODERN TIMES. HISTORY OF THE CRANIOTOMYChapter 25.Wilhelm Wagner's (1848-1900) temporary cranial resection and its initial improvements.Chapter 26.Surgeons between the old trepanation and the new craniotomy.Chapter 27.Eugène Louis Doyen (1859-1916), an innovative French surgeon and enthusiastic on the craniotomy.Chapter 28.Surgical instruments for craniotomy and the victory of the humble Gigli's saw.Chapter 29.Initial development: manual osteoplastic craniotomy.Chapter 30.Late development: powered osteoplastic craniotomy.Chapter 31.Evolution of indications of craniotomy.Chapter 32.Craniotomy at war times. World War I and World War II.Chapter 33.Craniotomy: Illustrative cases.Chapter 34.'State-of -the art' of the craniotomy in the early twenty-first century and future developments.

Summary: This book offers an ultimate clinical guide to all the medical issues related to triathlon ? a very popular Olympic and international sport, and the most modern of all the endurance activities. Triathletes experience a range of environmental conditions and physiological demands, depending on the race, that must be taken into consideration when preparing for medical assistance. The book addresses in detail the topics of cardiovascular adaptations, overuse injuries, overtraining syndrome, endurance anaemia, nutrition and the physiological aspects associated with the discipline. It provides information on the training and technical aspects of the different distances in triathlon disciplines, with a special focus on safety in open-water swimming. Dedicated chapters also cover issues related to female, young, master and para-triathletes. Combining research perspectives with many years of experience practicing in the field, this book offers sport medicine physicians, orthopedists, physical therapists and coaches a comprehensive guide to the evaluation, treatment and prevention of all the overuse conditions and to improving athletes? performance.

Summary: Wear and osteolysis are still the most important potential problems in total hip and knee arthroplasty. Although technology in arthroplasty has been improved dramatically during the past decade, the clinical data relating to some implants reveal that many concerns remain. During the "Tribology Day" within the scientific programme of the 2013 EFORT Congress in Istanbul, the main topics included these concerns as well as the benefits of the materials most commonly used in total hip and knee arthroplasty. This book includes the presentations delivered on the day and covers a range of interesting issues regarding metal, ceramic, and polyethylene articulations. It provides information on the current concepts relating to tribology in total hip arthroplasty and offers a critical outlook on possible improvements in total knee arthroplasty.

Summary: This book compiles the latest research in the area of Trichoderma Rhizosphere Biology. It covers topics such as microbial interaction, crosstalk between plants and microbes, interactions with abiotic and biotic factors, and advances in biocontrol agents, biofertilizers and biostimulants. The respective chapters describe innovative ways of adapting fungal communities to improve their survival in highly dynamic environments and agroecosystems. In closing, the book discusses the use of Trichoderma as a bio-growth enhancer and biostimulant for organic agriculture.

Contents:
Intro
Foreword
Preface
Contents
Editors and Contributors
Abbreviations
Chapter 1: Can We Define an Experimental Framework to Approach the Genetic Basis of Root Colonization?
1.1 Introduction
1.1.1 Trichoderma as an Opportunistic Symbiont of Plant Roots
1.1.2 Root Colonization and the Plant Immune Response
1.2 Mapping and Quantifying the Trichoderma-Root Interaction
1.2.1 Imaging
1.2.2 Quantification of Trichoderma Root Colonization
1.3 Physiological and Environmental Factors
1.4 Trichoderma Genetic Determinants of Colonization 1.5 Plant Genetic Determinants of Colonization
1.6 Conclusion
References
Chapter 2: The Vocabulary of Trichoderma-Plant Interactions
2.1 Introduction
2.2 Microbial Phytohormones
2.3 Proteins
2.4 Secondary Metabolites
2.4.1 Microbial Volatile Organic Compounds
2.4.2 Other SM
2.4.2.1 Peptaibols
2.5 Conclusion
References
Chapter 3: Could Trichoderma Be a Plant Pathogen? Successful Root Colonization
3.1 Introduction
3.2 Root Colonization by Trichoderma
3.3 Benefits Obtained by the Plant from Successful Colonization 3.3.1 Induction of Systemic Resistance
3.3.2 Increased Tolerance to Abiotic Stress
3.3.3 Increase in Nutrient Intake
3.3.4 Biostimulant Capacity
3.4 Trichoderma as a Plant Pathogen: The Importance of SA
3.5 Conclusions
References
Chapter 4: Harnessing the Perception of Trichoderma Signal Molecules in Rhizosphere to Improve Soil Health and Plant Health
4.1 Introduction
4.2 Root Exudates and Rhizosphere Colonization by Trichoderma
4.3 Rhizosphere Specificity of Trichoderma
4.4 Trichoderma CWDE and MAMP Molecules on Root Colonization 4.5 MAMP and DAMP Molecules of Trichoderma-Mediated Systemic Resistance
4.6 Trichoderma Proteins Involved in Root Colonization
4.7 Molecular Signals of Trichoderma and ISR
4.8 Secondary Metabolites of Trichoderma and Their Diverse Mode of Action
4.9 Interaction of Trichoderma Growth Promotional Molecules in the Rhizosphere
4.10 Trichoderma as Nutrient Mobilizers
4.11 Molecular Signals of Trichoderma in the Rhizosphere Complements Plant and Soil Health
4.12 Conclusion
References Chapter 5: Plant Immunity, Priming, and Systemic Resistance as Mechanisms for Trichoderma spp. Biocontrol
5.1 Introduction
5.2 Induction of ISR in the Host
5.3 Trichoderma Priming for Enhanced Defense
5.4 Root and Leaf Colonization by Trichoderma spp.
5.5 Plant Diseases Resistance Conferred by Trichoderma
5.6 Concluding Remarks and Outlook
References
Chapter 6: Systemically Induced Resistance Against Maize Diseases by Trichoderma spp.
6.1 Introduction
6.2 Induced Resistance: SAR and ISR
6.3 Trichoderma-Associated Induced Resistance in Maize Plants

Summary: This book provides a comprehensive overview of the physiology, pathophysiology, diagnosis, medical and surgical management, and future therapies for tricuspid valve disease. It is divided into two sections. The first section covers the basics of the tricuspid valve, including anatomy, epidemiology, and clinical diagnosis with individual chapters focused on hemodynamics, echocardiography, MRI, and CT assessment. The second section examines current treatments for tricuspid valve disease including both surgical and medical management. It discusses special clinical scenarios of tricuspid valve pathology such as tricuspid regurgitation in patients with ICD and pacemaker implants and the role of tricuspid valve disease in patients with heart failure and LVAD therapy. Tricuspid Valve Disease: A Comprehensive Guide to Evaluation and Management is an essential resource for general cardiologists, interventional cardiologists, cardiac surgeons, and innovators in the field of structural heart disease. .

Contents:
Part I. Tricuspid Valve Basics
Chapter 1. Anatomy of the Tricuspid Valve
Chapter 2. Epidemiology, Pathophysiology and Natural History of Tricuspid Valve Regurgitation
Chapter 3. Epidemiology, Pathophysiology and Natural History of Tricuspid Valve Stenosis
Chapter 4. Clinical Assessment of the Patient with Tricuspid Valve Disease
Chapter 5. Hemodynamic Assessment of Tricuspid Valve Disease
Chapter 6. Echocardiographic Assessment Tricuspid Valve Disease.-Chapter 7. MRI Assessment of the Tricuspid Valve and Right Heart
Chapter 8. CT Assessment of the Tricuspid Valve and the Right Heart
Chapter 9. Putting it All Together: Phenotyping the Patient with Tricuspid Valve Disease
Part II. Current Management of Tricuspid Valve Disease.-Chapter 10. Medical Management of Primary Tricuspid Regurgitation
Chapter 11. Medical Management of Secondary Tricuspid Regurgitation
Chapter 12. Surgical Management of Tricuspid Valve Disease.-Chapter 13. Tricuspid Regurgitation and Right Ventricular Dysfunction
Chapter 14. Evaluation and Management of Tricuspid Regurgitation in Patients with ICD/Pacemakers
Chapter 15. Evaluation and Management of Tricuspid Regurgitation in Patients Being Considered for LVAD
Part III. Forthcoming Percutaneous Therapies for Tricuspid Valve Regurgitation
Chapter 16. The Landscape and Potential of Percutaneous Therapies for Tricuspid Valve Disease
Chapter 17. Annuloplasty Based Strategies
Chapter 18. Coaptation Strategies
Chapter 19. Valve Replacement.

Summary: This book is devoted solely to the tricuspid valve and its role in congenital heart disease. Tricuspid valve anomalies are part of the pathological spectrum in various congenital heart diseases, including Ebstein anomaly and tricuspid valve dysplasia, with different pathophysiology and clinical implications. This book covers all relevant aspects of such anomalies, including diagnosis, therapy, and follow-up. Further topics addressed include the way in which the tricuspid valve may become the 'systemic' valve in some congenital diseases, with important consequences, and the involvement of the tricuspid valve in the right-sided heart complications often seen in adults with congenital heart disease. All of the chapters are written by internationally recognized experts and are designed to deliver state of the art knowledge of practical value. This book will be an important addition to the library for surgeons, cardiologists, and other practitioners involved in the management of patients with congenital heart disease.

Contents:
Tricuspid Valve: Embryology and Anatomy
Tricuspid Valve Dysplasia: From Foetus to Adult
Genetics of Ebstein Anomaly
Ebstein's Anomaly in the Neonate
Ebstein Anomaly in Adolescents and Young Adults
Ebstein's Anomaly and Arrhythmia Management
The "Small" Tricuspid Valve
The "Systemic" Tricuspid Valve: The Tricuspid Valve in the Systemic Circulation Following Atrial Switch Operations for Transposition of the Great Arteries
The "Systemic" Tricuspid Valve: The Tricuspid Valve in Congenitally Corrected Transposition of the Great Arteries
The "Systemic" Tricuspid Valve in Hypoplastic Left Heart Syndrome
Tricuspid Valve Injury After Surgical/Transcatheter Procedures
The Tricuspid Valve in Adults with Congenital Heart Disease
The Rheumatic Tricuspid Valve
Surgical Techniques of Tricuspid Valve Repair in Patients Without Ebstein Malformation
Surgical Tricuspid Valve Replacement
Transcatheter Treatment of Tricuspid Valve
The Postoperative Treatment of Tricuspid Valve Surgery.

Summary: This book provides an overview of the history, anatomy, epidemiology, diagnosis (HPI, PE, Imaging), non-pharmacological management and medication management of trigeminal nerve pain. Nerve blocks for the trigeminal nerve and branches, Radiofrequency ablation, chemodenervation, cryotherapy, botox injections, neuromodulation infusion therapy, balloon compression gamma knife therapy, decompression surgery, peripheral neurectomy and the psychological impact are also examined with an algorithm for management recommendations included in the final chapter. Trigeminal Nerve Pain - A Guide to Clinical Management comprehensively covers how to manage patients with this often debilitating pain and is of use to trainees and practising internists, hospitalists, surgeons and anaesthesiologists seeking to increase their understanding of this complex condition.

Contents:
History
Anatomy of The Trigeminal Nerve
Epidemiology
Trigeminal Neuralgia and other Trigeminal Nerve Conditions
Diagnosis of Trigeminal Nerve Conditions
Non-Pharmacological Management
Physical Therapy and rehabilitation
Medication Management
Nerve Blocks for the Trigeminal Nerve and Branches
Radiofrequency ablation
Chemodenervation of Trigeminal Nerve
Cryotherapy
Botox Injections
Regenerative Medicine for Trigeminal Nerve Pain
Neuromodulation for the trigeminal nerve
Infusion Therapy
Balloon Compression of the trigeminal nerve
Radiosurgery for Treatment of Trigeminal Neuralgia
Microvascular Decompression for Treatment of Trigeminal Neuralgia
Peripheral Neurectomy
The Psychological Impact and Management of Trigeminal Neuralgia
Algorithms for Management Recommendations.

Contents:
Models for myofascial chains
Physiology
The craniosacral model
The biomechanical model of John Martin Littlejohn : mechanics of the spine
Postural muscles, phasic muscles and crossed syndrome
Zink patterns
Myofascial chains : a model
Posture
Diagnostics
Therapy
Definition
Classification of trigger points
Pathophysiology of trigger points
Diagnosing trigger points
Trigger point therapy
Trigger point perpetuating factors
Facilitated segments
Trigger points.

Summary: This guide provides practical information that will assist clinicians involved in the diagnosis, assessment, treatment, and follow-up care of patients with triple-negative breast cancer. After opening chapters on pathologic evaluation, clinical presentation, genetics, and imaging features, the full range of current treatment approaches is thoroughly reviewed from a multidisciplinary perspective. Readers will find up-to-date information and guidance on surgical management, radiation therapy, tailored adjuvant therapy, neoadjuvant treatment, systemic treatment for metastatic disease, and molecular profiling and targeted therapy. The coverage is completed by discussion of special issues in young women and individualization of the management approach in older patients. All healthcare professionals who care for patients with triple-negative breast cancer will find the book to be an invaluable source of expert advice on the issues faced in real-world practice.

Contents:
1. Pathologic evaluation of triple-negative breast cancer
2. Triple-negative breast cancer: Clinical features
3. The genetics of triple-negative breast cancer
4. Imaging features and modalities of triple-negative breast cancer
5. Surgical management of triple-negative breast cancer
6. Radiation therapy for triple-negative breast cancer
7. Tailoring adjuvant therapy for triple-negative breast cancer: Selection of agents
8. Neoadjuvant treatment of triple-negative breast cancer
9. Systemic treatment of metastatic triple-negative breast cancer Page 3 of 3
10. Molecular profiling and targeted therapy for triple-negative breast cancer
11. Special issues in the young woman with triple-negative breast cancer
12. Individualizing the approach to the older woman with triple-negative breast Cancer.

Summary: This book covers the current research on the plant-based tropane alkaloids (TA) and TA-bearing plants. The first part includes an overview of "tropane alkaloids in context to diversity, biosynthesis and significance. The second part covers aspects of in-vitro and allied interventions in these alkaloids. TAs belong to one of the world's oldest phytomedicines with their valuable ethno-pharmacological applications. The book compiles scientific ideas, perspectives and challenges in this area. Further, the book attempts to investigate the loopholes in existing methodologies, challenges and possible solutions through well thought-out scientific discussions from various eminent research groups. This book is of high interest to students and researchers in biotechnology, plant biology and pharmacology. As the TAs are of high commercial medicinal value, this book is also a relevant collection of articles for industry experts Publisher description

Contents:
Part 1. Tropane Alkaloids: Diversity, Biosynthesis and Significance. Plant Tropane Alkaloids (TAs): Chemotaxonomic Significance, Biogenesis and Biotechnological interventions ; Structure and Function of Enzymes Involved in the Biosynthesis of Tropane Alkaloids ; Plant tropane alkaloids: Commercial stature and production developments
Part 2. Tropane Alkaloids: In vitro and allied interventions. Involvement of various biotechnological contrivances for tropane alkaloids biosynthesis and applications of tropane alkaloid bearing in vitro cultures ; Hairy root cultures and plant tropane alkaloids: production matrix and product in biotechnological perspective ; Production of Tropane Alkaloids (TAs) in plants and in vitro cultures of different ploidy levels ; Current Progress in Tropane Alkaloids Production by Transgenic and Heterologous gene Expression Approaches ; Tropane Alkaloid Biosynthesis in Plants: Insights from Transcriptome Analysis ; Transcription Factor and MicroRNA-mediated Manipulation of the Tropane Alkaloids Biosynthesis.

Summary: The book covers 75 autopsy-based cases (about 75) of common and uncommon presentations of various cardiovascular diseases (CVDs). It emphasizes the importance of the autopsies, which have played a pivotal role in the understanding of the pathology and hence the clinical manifestations of several CVDs. The book attempts to present the material from the perspective of the autopsy table. It uses the clinical data as the initial framework and the autopsy findings to develop a true understanding of the disease and the associated pathophysiology of the condition with final clinico-pathological correlation. Each case covers a complete journey of the deceased patient concisely under the following headingstitle, clinical history, autopsy findings and discussion, which includes a brief review of the literature. The text is accompanied by relevant high-quality macroscopic and microscopic images. The book is relevant for specialists in pathology, cardiology, cardiac surgery, internal medicine, critical care and pediatrics.

Contents:
Utility of Autopsy with Special Reference to Cardiovascular Diseases
Basic Cardiac Anatomy and Dissection
Autopsy-based Clinicopathological Cases of Pericardial Diseases
Autopsy-based Clinicopathological Cases of Post-inflammatory Valvular Anomalies
Autopsy-based Clinicopathological Cases of Infective/Inflammatory Valvular Anomalies
Autopsy-based Clinicopathological Cases of Non-inflammatory Valvular Anomalies
Autopsy-based Clinicopathological Cases of Ischemic Myocardial Disorders
Autopsy-based Clinicopathological Cases of Non-ischemic Myocardial Disorders
Autopsy-based Clinicopathological Cases of Cardiac Tumors (Primary / Secondary)
Autopsy-based Clinicopathological Cases of Systemic Vascular Pathology
Autopsy-based Clinicopathological Cases of Pulmonary Vascular Pathology. .

Summary: This book introduces the changing patterns of schistosomiasis transmission in China at different stages. Arduous efforts have been made in the last 7 decades to control and eliminate schistosomiasis in China using various control strategies, such as snail control to reduce the intensity of the disease transmission, morbidity control to reduce disease prevalence, and integrated control strategies to block the disease transmission, supported by governments at different levels. This book also presents the scientific progresses which technically support the control and surveillance of schistosomiasis in the field. It summarizes the working mechanism and control strategies of multi-sectoral collaboration to promote the national control programme leading to schistosomiasis elimination eventually.

Contents:
History of Schistosomiasis Japonica in China
Schistosomiasis Endemic, Diagnosis and Treatment in China
Biology and Control of Oncomelania Snail in China
Progress on Schistosomiasis Research in China
Chinas Experiences in the Combat of Schistosomiasis
National Plan for Schistosomiasis Control and Achievements.

Summary: The book brings together research topics having a broad focus on human and climate change impacts on the terrestrial ecosystems in the tropics in general and more specifically from the most significant and vulnerable Himalayan ecosystem. A total of 16 contributions included in the book cover a diverse range of global change themes such as the impacts of changing temperature and precipitation on soil ecosystems, forest degradation, extent and impacts of invasive species, plant responses to pollution, climate change impacts on biodiversity and tree phenology, environmental changes associated with land use, importance of traditional knowledge in climate change adaptation, timberline ecosystems, and role of integrated landscape modeling for sustainable management of natural resources. The book is a collective endeavour of an international multidisciplinary group of scientists focused on improving our understanding of the impacts of global change on the structure and functioning of tropical ecosystems and addressing the challenges of their future sustainable management. We hope that the book will help researchers working in the areas of ecology and environmental science to update their knowledge. We also expect that natural resource managers and policy planners will find explanations for some of their observations and hypotheses on multiple global change factors impacting tropical ecosystems and especially Himalayan ecosystems.

Contents:
Intro; Preface; Contents;
1: Introduction; References;
2: Influence of Changing Patterns of Precipitation and Temperature on Tropical Soil Ecosystem; 2.1 Introduction; 2.2 Soil and Its Importance; 2.3 Effect of Temperature and Precipitation on Soil Processes; 2.3.1 Nutrient Cycling; 2.3.2 Decomposition and Mineralization; 2.3.3 Soil CO2 Flux; 2.3.4 Microbial Biomass; 2.4 Effect of Temperature and Precipitation on Soil Properties; 2.4.1 Soil Carbon; 2.4.2 Soil Nitrogen; 2.5 Conclusion; References;
3: Nature and Extent of Forest Degradation in Central Himalayas; 3.1 Introduction 3.2 Extent of Forest Degradation in the Himalayas; 3.2.1 Forest Biomass, Carbon Sequestration, and Other Ecosystem Functions; 3.2.2 Fine Roots and Mycorrhizae; 3.2.3 Grazing Trails; 3.2.4 Impact of Degradation on Seed and Seed Germination; 3.3 Structural and Physiological Changes in Individual Trees Due to the Chronic Disturbances of Stands; 3.3.1 Parasite Infestation in Degraded Oak Forests; 3.4 Impact of Ban on Tree Cutting on Forest Degradation and Species Composition; 3.5 Recovery of Degraded Oak Forest Ecosystem; 3.6 Comparison with Forests Affected by Shifting Cultivation 3.7 Interventions to Check Forest Degradation; 3.8 Conclusion; References;
4: Management of Invasive Alien Plants in Nepal: Current Practices and Future Prospects; 4.1 Introduction; 4.2 Overview of Invasive Plants in Nepal; 4.2.1 Diversity and Distribution; 4.2.2 Impacts; 4.3 Management; 4.3.1 Current Management Practices; 4.3.1.1 Cultural Methods; 4.3.1.2 Physical Methods; 4.3.1.3 Chemical Methods; 4.3.1.4 Biological Methods; 4.3.2 Policy Responses; 4.3.2.1 National Report to the Convention on Biological Diversity (CBD); 4.3.2.2 National Biodiversity Strategy 4.3.2.3 Invasive Species in Legal Documents; 4.3.2.4 National Strategy for Management of Invasive Alien Species; 4.3.3 Future Prospects for Management; 4.3.3.1 Opportunity for Eradication and Prevention; 4.3.3.2 Integrating Management of Invasive Plant Species in Community Forestry; 4.3.3.3 Management of IAPs in Protected Areas; 4.3.3.4 Risk Assessment; 4.3.3.5 Education and Research; 4.3.3.6 Biological Control Program; 4.3.3.7 Regional Collaboration; 4.4 Conclusion; References;
5: Invasive Species and Their Impact on Tropical Forests of Central India: A Review; 5.1 Introduction 5.2 A Brief Profile of Central India; 5.3 Plant Invasion; 5.3.1 Introduction Pathways; 5.3.2 Traits of Invasive Species; 5.3.3 Influential Factors and Successful Ecesis; 5.4 Invasive Species: Why Are They a Concern?; 5.5 Studies from Central India; 5.6 Diversity of Alien Invasive Taxa of Central India; 5.6.1 Family-Wise Distribution of Invasive Taxa; 5.6.2 Nativity of Invasive Taxa; 5.6.3 Life Forms of Invasive Taxa; 5.7 An Outline of the Most Common Top Ten Noxious Invaders of Central India; 5.7.1 Lantana camara L.; 5.7.2 Parthenium hysterophorus L.; 5.7.3 Ageratum conyzoides L.

Contents:
PUBLIC HEALTH ASPECTS
Geography and socioeconomics of the tropical areas
Epidemiology of cancer in the tropical areas
Management of cancers in countries with limited resources
Access to Expensive drugs and Ethical considerations
Precarity, social organization and outcome on cancer management in the tropical areas
Cancer screening and prevention in the tropical areas
Pathology and cancer research
Cancer perception in different cultures of the tropical areas ; Cross-cultural mediation
Cancer clinical trials in the tropical area
BASIC SCIENCE BACKGROUND
Spectrum of cancers due to micro-organisms (virus, bacteria, parasites)
HIV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HIV
HTLV1 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the retrovirus HTLV1
Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HBV
Hepatitis virus scientific background : Epidemiology and mechanism of carcinogenesis of the virus HCV
EBV and cancer; scientific background: Epidemiology of EBV and mechanisms of carcinogenesis
HPV and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HPV
HHV8 and cancer; scientific background: Epidemiology and mechanism of carcinogenesis of the virus HHV8
Parasites and cancer: Epidemiology and mechanism of carcinogenesis of schitosoma
Helicobacter and cancer: Epidemiology of Helicobacter Pylori and mechanisms of carcinogenesis
HEMOPATHIES
ATL (lymphoma et leukemia)
Extranodal NK/T-cell lymphoma, nasal type
High-grade lymphomas: Diffuse large B-cells lymphomas (with a special paragraph on CNS lymphomas)
High-grade lymphomas: Burkitt lymphoma; Physiopathology and treatment of EBV associated lymphomas
Mantle cell lymphoma
Indolent lymphomas, follicular lymphomas, HVC associated marginal zone B-cell lymphomas and Waldenström disease
Chronic myeloproliferative syndroms
Myelodysplasic syndroms
Acute leukemias
CANCERS
Breast cancer
Cervix cancer
Oesophageal cancer
Gastric cancer
Colorectal cancer
Hepatocarcinoma
Cholangiocarcinoma
Pancreas cancer
Lung cancer
Head and neck cancers
Bladder cancer
Prostate cancer
Renal cancer
Cutaneous cancers (including melanoma)
Ovarian cancer
Endometrial cancer
Cancer of the penis, anus and vulva
Gestational trophoblastic tumors
CNS tumors
Thyroid cancer
Uncommon cancers
CANCER TREATMENT IN TROPICAL AREAS
Pediatric oncology
Geriatric oncology
Surgery
Radiotherapy
Medical treatments (chemotherapy, hormone therapy, targeted drugs)
HIV and cancer treatments
Supportive cares
Palliative cares.

Summary: An ideal learning and revision guide for students and trainees providing a concise overview of the key topics in tropical medicine including infections caused by bacteria, viruses, fungi, protozoa and vector biology, disease syndromes, and envenomation. Using diagrams, maps, and tables the material is present in an accessible and engaging way.

Contents:
Section 1. Bacterial infections of relevance to the tropics
Section 2. Viral infections of relevance to the tropics
Section 3. Fungal infections of relevance to the tropics
Section 4. Helminth infections of relevance to the tropics
Section 5. Protozoal infections of relevance to the tropics
Section 6. Vectors and ectoparasites
Section 7. Disease syndromes occurring in the tropics
Section 8. Envenomation.

Summary: This unique book provides an introduction to the fascinating field of tropical nephrology, covering nephrology, infectious diseases and tropical medicine. These topics are connected since numerous infectious and parasitic diseases affect the kidneys and are endemic in the tropical areas of the globe. Considered neglected tropical diseases by the World Health Organization, they are largely linked to poverty and lack policies to prevent, treat and decrease their prevalence and incidence. The tropics currently encompass nearly 150 countries and account for 40% of the world's population, and it is predicted that by 2050 this figure will rise to 55%. Most of the countries in the tropical regions have been classified by the World Bank as low-middle income countries and have limited access to services, including health care. As such, this highly topical book is of interest to a large number of healthcare professionals and researchers who are in contact with tropical diseases, especially those investigating their complications, such as kidney injury. Divided into 23 chapters, it describes the most prevalent tropical diseases and conditions that affect the kidneys. It also presents the most recent epidemiological data, clinical manifestations, details of kidney involvement, including the pathophysiology of kidney injury, and the current treatment for each disease.

Contents:
Intro
Foreword
Acknowledgments
Contents
Editors and Contributors
Editors
Contributors
Chapter 1: Tropical Diseases: A Public Health Problem with Impact on Nephrology
1.1 Geography of the Tropics
1.2 Overview of Tropical Renal Diseases
1.3 Public Health Risk Dimensions That Have an Impact on Tropical Renal Diseases
1.3.1 Environmental Factors
1.3.2 Socioeconomic Factors
1.3.3 Process of Care Factors
1.3.3.1 Shortage of Nephrologist in the Tropics
1.3.4 Exposure Factors
1.4 Inherent Factors 1.5 Tropical Renal Diseases and the "One Health" Approach
1.6 Strategies to Improve AKI Recognition in the Tropics
1.6.1 Risk Assessment and Use of Clinical Risk Scores
1.6.2 Increased Recognition of AKI by Electronic Alerts and Telemedicine
1.7 Conclusion
References
Chapter 2: Renal Function Evaluation in Tropical Diseases
2.1 Introduction
2.2 Clinical Assessment of Renal Function (Glomerular Filtration)
2.3 Methods and Equations That Estimate Glomerular Filtration Rate
2.4 Equations Used to Estimate Renal Function Based on Serum Creatinine Levels 2.5 Recommendations to Better Estimate Renal Function Through Glomerular Filtration Rate in Clinical Practice
2.6 Tubular Function Assessment
2.6.1 Fractional Excretion of Sodium (FENa+)
2.6.2 Transtubular Potassium Gradient (TTKG)
2.6.3 Urine/Plasma Osmolarity Ratio
2.6.4 Solute-Free Water Transport
2.6.5 Plasma Osmolarity
2.6.6 Urinary Acidification Test
2.6.7 Urinary Concentration Test
References
Chapter 3: Snakebites Accidents and Renal Complications
3.1 Introduction
3.2 Species Involved in Snakebite Accidents 3.3 Main Snake Venom Activities and Components
3.4 Clinical Characteristics of Envenomations
3.5 Treatment
3.6 Systemic and Local Complications
3.7 Kidney Injury in Snakebite Accidents
3.8 Management of Kidney Injury in Snakebite Accidents
References
Chapter 4: Hemorrhagic Accidents Caused by Lonomia obliqua
4.1 Introduction
4.2 Epidemiology
4.3 Lonomia Venom Mechanism of Action
4.4 Clinical Picture
4.5 Diagnosis
4.6 Treatment
4.7 Prognosis
4.8 Choosing Wisely
References
Chapter 5: Toxic Acute Kidney Injury
5.1 Introduction 5.2 Epidemiology of Acute Poisonings
5.3 Medicines
5.3.1 Non-steroidal Anti-inflammatory Drugs (NSAID)
5.3.2 Acetaminophen
5.3.3 Psychotropics
5.4 Pesticides
5.4.1 Household Cleaners
5.4.2 Natural Plant Substances
5.5 Legal and Illegal Drugs
5.5.1 Alcohol
5.5.2 Cocaine
5.5.3 Synthetic Cannabinoids
5.5.4 Heroin
5.5.5 Amphetamines
5.6 Venomous Animals
5.6.1 Snakes
5.6.2 Wasps
5.6.3 Spiders
5.7 Elimination Methods - Dialysis
References
Chapter 6: Tropical Diseases in Kidney Transplantation
6.1 Introduction
6.2 Transmission Routes 6.3 Clinical Presentation Particularities

Summary: "In this dazzling debut, Carla Shalaby, a former elementary school teacher, explores the everyday lives of four young "troublemakers," challenging the ways we identify and understand so-called problem children. Time and again, we make seemingly endless efforts to moderate, punish, and even medicate our children, when we should instead be concerned with transforming the very nature of our institutions, systems, and structures, large and small. Through delicately crafted portraits of these memorable children--Zora, Lucas, Sean, and Marcus--Troublemakers allows us to see school through the eyes of those who know firsthand what it means to be labeled a problem. From Zora's proud individuality to Marcus's open willfulness, from Sean's struggle with authority to Lucas's tenacious imagination, comes profound insight--for educators and parents alike--into how schools engender, exclude, and then try to erase trouble, right along with the young people accused of making it. And although the harsh disciplining of adolescent behavior has been called out as part of a school-to-prison pipeline, the children we meet in these pages demonstrate how a child's path to excessive punishment and exclusion in fact begins at a much younger age. Shalaby's empathetic, discerning, and elegant prose gives us a deeply textured look at what noncompliance signals about the environments we require students to adapt to in our schools. Both urgent and timely, this paradigm-shifting book challenges our typical expectations for young children and with principled affection reveals how these demands--despite good intentions--work to undermine the pursuit of a free and just society" -- Provided by publisher.

Contents:
Part One. Forest school. Zora : on being out-standing
Lucas : on being pigeonholed
Part Two: The crossroads school. Sean : on being willful
Marcus : on being good
Conclusion: trouble-making in school
A letter to teachers: on teaching love and learning freedom
A note to all readers: on mushroom, mold, and mice.

Contents:
Cell Biology for Immune Evasion: Organizing Antigenic Variation, Surfaces, Trafficking, and Cellular Structures in Trypanosoma brucei / Ka Fai Leung, Paul T. Manna, Cordula Boehm, Luke Maishman and Mark C. Field
The Biology of Tsetse-Trypanosome Interactions / Guy Caljon, Linda De Vooght and Jan Van Den Abbeele
Withstanding the Challenges of Host Immunity: Antigenic Variation and the Trypanosome Surface Coat / James Peter John Hall and Lindsey Plenderleith
Bridging Innate and Adaptive Immunity in African Trypanosomiasis / John M. Mansfield, Donna M. Paulnock and Gina M. Hedberg
Adaptive Immunity and Trypanosomiasis-Driven B-Cell Destruction / Stefan Magez and Magdalena Radwanska
Normal Human Serum Lysis of Non-human Trypanosomes and Resistance of T. b. rhodesiense and T. b. gambiense / Paul Capewell, Caroline Clucas, William Weir, Nicola Veitch and Annette MacLeod
Proteomics and African Trypanosomes: Shedding New Light on Host-Vector-Parasite Interactions and Impact on Control Methods / Philippe Holzmuller, Pascal Grébaut and Anne Geiger
Diagnosis of African Trypanosomiasis / Philippe Büscher
Progress Towards New Treatments for Human African Trypanosomiasis / Jose A. Garcia-Salcedo, Jane C. Munday, Juan D. Unciti-Broceta and Harry P. de Koning
Animal African Trypanosomosis in Sub-Saharan Africa and Beyond African Borders / Boniface Namangala and Steven Odongo
Trypanosoma (Duttonella) vivax and Typanosomosis in Latin America: Secadera/Huequera/Cacho Hueco / Mary Isabel Gonzatti, Bernardo González-Baradat, Pedro M. Aso and Armando Reyna-Bello.

Summary: In this completely revised edition an international team of experts presents nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, the book also provides detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis. This book is a resource for anyone working to prevent and treat tuberculosis and associated infections, from inf.

Contents:
Towards Edward Jenner's revenge: developing an effective tuberculosis vaccine
Drug discovery and development: state of the art and future directions
Biomarkers and diagnostics
Host and strain diversity
The signature problem of tuberculosis persistence.

Contents:
History of tuberculosis and of warfare / J.F. Murray
Challenges in the assessment of tuberculosis epidemiology during wartime / H.L. Rieder, R. Loddenkemper
Risk factors for the increase of tuberculosis during wartime / R. Loddenkemper, H.L. Rieder
Nazi medicine, tuberculosis and genocide / A. Finley-Croswhite, A. Munzer
Tuberculosis in Germany before, during and after World War II / R. Loddenkemper, N. Konietzko
Tuberculosis in Austria before, during and after World War II / K. Wolf, E. Junker
Tuberculosis in Poland before, during and after World War II / A. Magowska
Tuberculosis in the United Kingdom and Ireland before, during and after World War II / P.D.O. Davies, R. Trafford
Tuberculosis in France before, during and after World War II / J. Grosset, A. Trabucq
Tuberculosis in The British Empire before, during and after World War II / J.F. Murray
Tuberculosis in Australia before, during and after World War II / C. Putland
Tuberculosis in South Africa before, during and after World War II / N. Beyers, R. Gie
Tuberculosis in The Netherlands before, during and after World War II / M.R.A. van Cleeff, E. Hueting, A. Dessing
Tuberculosis in Belgium before, during and after World War II / M. Wanlin
Tuberculosis in Southern European Countries and the Balkans before, during and after World War II / G. Sulis, L. D'Ambrosio, R. Centis, R. Duarte, J.-M. García García, G.B. Migliori
Tuberculosis in Hungary before, during and after World War II / G. Kovács, I. Gaudi, I. Hovráth
Tuberculosis in the Soviet Union before and during World War II / M.V. Shulgina, I.A. Vasilyeva
Tuberculosis in the United States before, during and after World War II / P.C. Hopewell
Tuberculosis in Japan before, during and after World War II / T. Mori, N. Ishikawa
Tuberculosis in Korea during the Japanese occupation in World War II / E.K. Choi
Tuberculosis in China before, during and after the Sino-Japanese War / J.F. Murray
Tuberculosis and war : lessons learned from World War II / R. Loddenkemper, J.F. Murray.

Summary: With the rapid development of economy and international communication, world population mobility increase significantly. As migrating population is one of vulnerable populations to infectious diseases, strengthening monitoring system and intervention approaches will be a key factor in controlling the spread of infectious diseases. This book is intended to provide valuable information on creating effective prevention and intervention strategies of tuberculosis, taking Shenzhen, one of typical immigrant cities, as an example. Followed by overview of tuberculosis, the control strategy, diagnosis and treatment of tuberculosis, drug resistant tuberculosis, and HIV-associated tuberculosis in migrating population is introduced. In addition, application of innovative technologies, for example, internet, molecular biology, and artificial intelligence in tuberculosis control is presented. It will be a useful reference for practitioners in centers for infectious disease control and prevention, hospitals, academic institutions, as well as staff in government agencies and non-government organizations with interests in tuberculosis prevention and control.

Contents:
Intro; Preface; Contents; About the Editors; Contributors;
1: Overview of Tuberculosis; 1 Prevalence of Tuberculosis; 1.1 Concept of Tuberculosis and Its Evolution; 1.2 WHO and Evolution of Strategies for Tuberculosis Control; 1.3 Prevalence of TB Worldwide; 1.4 Prevalence of TB in China; 2 Current TB Control; 2.1 Commitment of the Chinese Government Concerning the Eradication of TB; 2.2 Completion of a New Service System for Prevention and Treatment of TB; 2.3 Advancement of Modern Strategy for Control of TB; 3 Development in the Diagnosis of Pulmonary Tuberculosis 3.1 Bacteriological ExaminationSmear Detection; Culture Detection; Nucleic Acid Amplification; 3.2 Imaging Diagnosis of Pulmonary TB; Chest High Voltage Photography; Computed Tomography (CT); Magnetic Resonance Imaging (MRI); 3.3 B-mode Ultrasonography; Thoracic TB; Tuberculous Pleurisy; 3.4 Fibrobronchoscopy; Principles of Fibrobronchoscopy; The Common Demonstrations of Bronchial TB by Fibrobronchoscopy; 3.5 Serological Diagnosis; 3.6 Detection of Cellular Immune Response; References;
2: Epidemiology of Tuberculosis in Migrating Population; 1 Status Quo of the Migrating Population 1.1 Overview of the Migrating Population1.2 Migration of Population in the Developed Countries; 1.3 Migration Populations in the Developing Countries of Africa and Latin America; 1.4 Status Quo of Migrating Population in China; 2 Prevalence of TB in Migrating Population; 2.1 Prevalence of TB in Migrating Population; 2.2 Prevalence of TB in Migrating Population; Temporal Distribution; Regional Distribution; Populations Distribution; Age Distribution; Gender Difference; Race Difference; Occupation Distribution; Percentage of New Smear-Positive TB Patients in the Migrating Population Patients with TB in the Migrating Population are Mainly Initially Treated Patients3 Surveillance of TB; 3.1 Surveillance of TB Prevalence; Routine Report of TB Prevalence; Basis of Reporting; Data of Reporting; Quality Control; Commonly Selected Indices in Quality Assessment; Annual Infection Rate of TB; Reporting Incidence of TB; Reporting Mortality of TB; Percentage Increase/Decrease of Reported Cases of TB; TB Reporting Rate; Timely Reporting Rate of TB; Missed Reporting Rate of TB; Timely Review Rate of TB Reporting; Duplicate TB Reporting Rate; Completeness of Valid ID No. Population DistributionAge; Gender; Occupation; Family History; Regional Distribution; Chronological Distribution; Epidemiological Data of TB in 2007-2016 in Shenzhen [32, 33]; Occurrence of TB; Chronological Distribution; Regional Distribution; Gender and Age Distribution; Occupation Distribution; Epidemiological Survey of TB [34-36]; Data for Collection; Quality Control; Indices of the Survey; Morbidity of TB; Morbidity of Smear-Positive TB; Morbidity of Bacteriologically Positive TB; Gender/Age Morbidity of TB; Residence Morbidity of TB; Regional Morbidity of TB

Summary: Historically, tuberculosis was one of the first organisms associated with disease. Yet, despite progress, tuberculosis remains the most frequent cause of death in humans due to a single infectious agent. This text describes some of the recent, state-of-the-art advances related to our understanding of how this organism causes disease in humans, its mechanisms involved in parasitizing the host, as well as how the host resists or becomes susceptible to infection. We cover several of the molecular, biochemical and structural aspects of the bacterium responsible, Mycobacterium tuberculosis, and describe individual components of the host response and how these impact the course of disease. Although we cover only a very small portion of the field in this overview, we believe that there is a great deal of novel information present that will be valuable to any researcher or student of the field. We are at a stage where there are often more questions than sanswers, but use of the foundation that is now developing through the effort of tuberculosis researchers provides us with opportunities previously out of reach. This text provides overviews of the field in a number of different areas that will engage researchers interested in tuberculosis, and provide suggestions for ways to move forward. All of the authors hope that readers enjoy this taste of each area, and that their contributions will help others to make additional progress. Dr. Jeffrey D. Cirillo is a Regents Professor at Texas A & M University College of Medicine and the Director of the Center for Airborne Pathogens Research and Imaging with over 30 years of research in tuberculosis. Dr. Ying Kong is an Assistant Professor at the University of Tennessee Health Science Center with over 16 years of research in tuberculosis.

Contents:
1. Cell Wall Biosynthesis and Latency During Tuberculosis Infections
2. The Silent Plague: Regulation of Latent Tuberculosis Infections
3. Trehalose Dimycolate (Cord Factor) as a Contributing Factor to Tuberculosis Pathogenesis
4. Role of Myeloid-derived Suppressor Cells and Regulatory T-cells in the Tuberculous Granuloma
5. Interactions of Mycobacterium tuberculosis with Human Mesenchymal Stem Cells
6. Role of Mycobacterium tuberculosis PE and PPE proteins in pathogen-host interactions
7. Co-Infection with TB and HIV: Converging Epidemics, Clinical Challenges, and Microbial Synergy
8. Optical In Vivo Imaging in Tuberculosis Research
9. Mycobacteria Infection and Lipid Droplets
Host and Pathogen Stealing, Sharing and Storing Fat
10. Potential Immunology, Transcriptomics and Epigenomic Prediction Tools of the Future to Improve Tuberculosis Control.

Summary: This work contains updated and clinically relevant information about tuberculosis. It is aimed at providing a succinct overview of history and disease epidemiology, clinical presentation and the most recent scientific developments in the field of tuberculosis research, with an emphasis on diagnosis and treatment. It may serve as a practical resource for students, clinicians and researchers who work in the field of infectious diseases.

Contents:
Preface
1 Epidemiology
2 Pathogenesis
3 Clinical manifestations
4 Diagnosis
5 Treatment
6 Prevention
Index.

Summary: This book recounts the biology of M. bovis, followed by the status of bovine Tuberculosis (bTB) in African countries, primarily based on zoonotic and epidemiological field reports. Since the accumulation of data is valueless unless it led to practicable control measures, emphasis is put on locally adapted protocols for future control of the disease. In order to systematically evaluate the knowledge base of bTB, Epidemiologic Problem Oriented Approach (EPOA) methodology was used. The methodology is composed of two triads: i) the problem identification/characterization triad, which is mainly descriptive in nature, and ii) the problem management/solution/mitigation triad, which is mainly geared toward problem management/solution (see figure). The first triad comprises three pillars: i) agent ii) host, and iii) environment and the second one: i) therapeutics/treatment, ii) prevention/control, and iii) health maintenance/promotion. The two triads are linked together by the diagnostic procedure linkage. The systematic and detailed studies of the 'Host-Agent-Environment interactions are the building blocks to the understanding of agent transmission pathways and disease spread. These may include data about the disease status of the country, the nature of the disease agent and its hosts, the modes of transmission, the wildlife reservoirs in nature, persistence of infection, and agent survival in animal products and the environment. The problem identification and characterization triad identifies these interactions. Once a problem has been identified and well understood, the next step is to minimize the risk of transmission and spread of a disease. This area, referred to as problem solution/management triad, consists of problem management alternatives that rely upon prevention/control, and health maintenance/promotion of the disease in livestock, wildlife, and humans with the emphasis on resource-poor, developing countries in Africa.

Contents:
Section 1 Human and animal tuberculosis in Africa
Introduction
The current status of bovine tuberculosis in Africa
Bovine TB Zoonosis in Africa
The control of Mycobacterium bovis infections in Africa: a One Health approach
Tuberculosis in African Wildlife
The Mycobacterium tuberculosis Complex in Africa
Section 2
Epidemiology of bovine tuberculosis in Africa
The epidemiology of bovine tuberculosis in Africa
Molecular epidemiology of Mycobacterium bovis in Africa
The diagnosis of bovine tuberculosis
The control of bovine tuberculosis in Africa
Section 3 Country reports
Bovine tuberculosis: Status, epidemiology, and public health implications in Burkina Faso
The status of bovine tuberculosis in Cameroon
Bovine tuberculosis in Egypt
The status of bovine tuberculosis in Ethiopia: Challenges and opportunities for its future control and prevention
Bovine tuberculosis in Ghana
The status of bovine tuberculosis in Malawi
Bovine tuberculosis in Nigeria: Historical perspective, burden, risk factors, and challenges for its diagnosis and control
Bovine tuberculosis in Rwanda
BTB control strategies in livestock and wildlife in South Africa
Bovine tuberculosis in the Republic of Sudan: A critical review
A changing landscape of bovine tuberculosis in Tanzania
Holes and patches: An account of tuberculosis caused by Mycobacterium bovis in Uganda
Bovine tuberculosis in Zambia.

Summary: This book is targeted at ensuring frontline clinical staff including seniors, trainees and specialist nurses can easily reference the optimum investigation and management of potential TB cases. This will mirror the annual London Advanced TB course which aims to equip all of the team delivering care to have a working knowledge of the entire spectrum of the real life aspects of TB management ranging from investigation of active TB to latent screening in pre biologic therapy. It includes an update of MDR TB management and also the approaches needed to ensure the entire medico-social spectrum of TB care is addressed.

Contents:
Trends in TB epidemiology
Natural History of TB and latent TB
The BCG vaccine
Contact tracing and screening new entrants science, rationale and progress
Pulmonary, Pleural and Mediastinal TB clinical aspects and diagnosis
Lymph Node/ Abdominal/ Renal /Pericardial TB clinical aspects, diagnosis and managing paradoxical reactions
Radiology of TB
Routine Laboratory Diagnostic Techniques
TB and HIV issues
Spinal and Bone TB
CNS and Meningeal TB management
Molecular tools current and future applications in the reference laboratory
Therapeutic Drug Monitoring
MDR TB Management
The interferon gamma release assays science and rationale
TB in renal disease
Anti-TNF, immunosuppression approaches in TB
Occupational Health Screening
Infection Control
Supporting the Hard to Reach
Incident Management and Mass screening
Paediatric TB Issues
TB treatment and complications
A Global TB Overview.

Contents:
Part I. General considerations
Part II. Tuberculosis of the brain and its coverings
Part III. Tuberculosis of the spine and its coverings
Part IV. Tuberculosis of the cranial and peripheral nerves
Part V. Laboratory studies in neuro-tuberculosis
Part VI. Therapy of tuberculosis of the nervous system and its coverings
Part VII. Tuberculosi in humans
Part VIII. Further insights into tuberculosis
Conclusion
Author index
Subject index.

Summary: Tuberculosis is an important concern in numerous countries across the globe. Training is usually focused on pulmonary tuberculosis, and the nuances of diagnosis and management of extrapulmonary tuberculosis, including abdominal tuberculosis, are not usually emphasized. This book details the varied presentations and mimics of tubercular involvement of the abdomen and the gastrointestinal system. The book provides clear guidance to the clinicians to diagnosis and manage the varied forms of abdominal tuberculosis. The chapters also touch on areas of controversy and confusion. Chapters are focused on each of the sites (intestinal, peritoneal, gastroduodenal, hepatobiliary, and pancreatic), modalities for evaluation (histology, microbiology, radiology, endoscopic ultrasound, nuclear medicine), differential diagnosis, and follow-up including response to treatment. Separate chapters have also been devoted to pediatric abdominal TB, therapy-related hepatitis, and considerations in immunocompromised states such as HIV. Therefore, this book will help practice clinicians and serve as a one-stop resource for graduate students in internal medicine and fellows training in gastroenterology.

Contents:
Abdominal Tuberculosis: A historical perspective
Epidemiology of abdominal tuberculosis
Classification of abdominal tuberculosis
Esophageal Tuberculosis
Gastroduodenal tuberculosis Intestinal Tuberculosis
Differentiating Intestinal tuberculosis from Crohns disease
Imaging for intestinal tuberculosis
Peritoneal Tuberculosis: An overview
Differentiating peritoneal tuberculosis and peritoneal carcinomatosis
Imaging for peritoneal tuberculosis
Ascitic fluid testing for peritoneal tuberculosis
Hepatic tuberculosis
Biliary and gallbladder tuberculosis
Pancreatic tuberculosis Histology for the diagnosis of Abdominal Tuberculosis
Microbiological diagnosis of abdominal tuberculosis
Endoscopic ultrasound for gastrointestinal tuberculosis
Nuclear medicine in abdominal tuberculosis
Response to therapy in abdominal tuberculosis
Surgery for abdominal tuberculosis
Antitubercular therapy-related hepatitis
Pediatric abdominal tuberculosis Immunodeficiency and Abdominal Tuberculosis.

Summary: This book covers all aspects and dimensions of tuberculosis affecting the spine, starting from its historical perspective to modern trends in early diagnosis, management, and rehabilitation. This book is a treatise fulfilling all the existing wide lacunae in suspicion, clinical examination, diagnosis, and management of this disease which still dwells as a mystery in modern medicine. It presents very easy to follow management plan algorithms and keynotes for easy and ready reference in each chapter. It describes the recent advances in diagnostic modalities and the treatment regimes, along with controversies, that have been elucidated and concluded with firm and sound references from evidence-based literature. This book also showcases the varied presentations of the disease as per varied socio-economic strata and in different geographic regions along with the different, principle-based approach to the disease spectrum shall be discussed at length. It also includes different clinical settings and scenarios in the concerned chapters. This book is a ready reference guide for postgraduate trainees, post-doctoral trainees, and faculty and consultants of orthopedics and neurosurgery.

Contents:
1 Historical perspectives of musculoskeletal tuberculosis
2 History of tuberculosis spine (post att era)
3 Epidemiology of Tuberculosis of Spine
4 Anatomy and pathophysiology of TB spine
5 Clinical presentation, features and examination of a case of suspected tuberculosis
6 Microbiological diagnosis of spinal tuberculosis
7 Diagnostic Modalities in TB Spine - Clinical Laboratory diagnosis and technological advancements
8 Radiology in TB spine (X-rays, ultrasound, CT, MRI)
9 Role of Nuclear Medicine in TB Spine
10 FNAC and Biopsy Techniques in TB Spine
11 Differential diagnosis of Spinal Infections
12 TB spine in children
13 The Medical management of spinal tuberculosis
14 Multidrug Resistance and Extensively Drug Resistant Tuberculosis Diagnosis and Management Protocols
15 Complications and Management in Tuberculosis of the Spine
16 Surgical management of in TB spine indications and overview with postoperative protocols
17 Surgical Management of Cervical Spine Tuberculosis
18 Anterior Surgical Approaches- TB Spine
19 Posterior approach for TB Spine
20 Lateral Extracavitary Approach in the Surgical Management of Tuberculosis of the Spine
21 Drug eluting ceramics in the field of spinal infections
22 Extensile approaches to the spine in Tuberculosis
23 Role of Full Endoscopic Procedures in management of Tuberculosis of Spine
24 Surgical treatment of TB kyphosis
25 Post Tuberculosis Sagittal Balance of the Spine Challenges and Approach
26 TB spine in special conditions
27 Advancements in the Surgical Management of Spinal Tuberculosis
28 End point for TB spine?.

Contents:
TB prevention / Jean-Pierre Zellweger
Optimal diagnosis : how early and improved diagnosis can help prevent TB transmission / Sandra Vivian Kik, Zhi Zhen Qin & Madhukar Pai
Current transmission prevention methods : vaccination / Rosalind Rowland & Helen McShane
Current transmission prevention methods : reducing disease spread from infected individuals / Gregory J. Fox, Guy B. Marks & Warwick J. Britton
Special concerns for at-risk populations / Ivan Solovic & Vladimir Littva
Prevention of TB in the presence of coinfection and comorbid conditions / Dina Nair & Soumya Swaminathan
Public health, TB, immigration and travel challenge / Jean-Pierre Zellweger
Ask the experts : managing TB in clinical practice and the impact on transmission / Jean-Pierre Zellweger
Multiple choice questions : answers.

Summary: This book provides comprehensive, cutting-edge scientific data on acute and chronic tubulointerstitial nephritis, an area that has not been fully addressed in many nephrology textbooks. This book covers all relevant aspects of the disease, from historical aspects and pathogenesis to diagnosis, pathological findings, treatment, and prognosis and outcomes. The chapters also discuss both immune and non-immune mediated forms of the disease, as well as entities causing tubulointerstitial disease such as medications and toxins, infectious agents, autoimmune diseases, transplant rejection, genetic diseases, infiltrative disease and chronic kidney disease of unknown etiology. The text features up-to-date educational materials that will benefit both basic and clinical scientists. Written by experts in the field, Tubulointerstitial Nephritis is a valuable resource for clinicians, practitioners, researchers and trainees working in the field of nephrology and internal medicine.

Contents:
History and Epidemiology
A history of its conceptual evolution
Epidemiology of tubulointerstitial nephritis
Pathogenesis
Pathogenesis of Acute Tubulointerstitial Nephritis
Causes of Acute Tubulointerstitial Nephritis
Drugs associated with Acute Tubulointerstitial Nephritis
Viral-induced Tubulointerstitial Nephritis
Bacterial and parasitic-related tubulointerstitial nephritis
Tubulointerstitial nephritis due to autoimmune diseases
IgG4-Related Tubulointerstitial Disease
Anti-brush border antibody (ABBA)-associated tubulointerstitial disease
Transplant Rejection and Infection Associated Tubulointerstitial Nephritis
Non-immune Mediated
Genetic Diseases Associated with Tubulointerstitial Nephritis
Cystinosis
Chronic tubulointerstitial nephritis: Hypokalemia, hyperoxaluria, and hyperuricemia
Non-immunological Causes of Tubulointerstitial Disease
Reflux and Obstructive Nephropathy
Aristolochic Acid Nephropathy and Balkan Nephropathy
Chronic Kidney Disease of Unknown Etiology
Infiltrative Disease of the Tubulointerstitium
Diagnosis
Clinical features and laboratory findings in acute tubulointerstitial nephritis
Imaging modalities for acute tubulointerstitial nephritis
Pathology of Tubulointerstitial Nephritis
Treatment
Management of Tubulointerstitial Nephritis
Prognosis/Outcomes
Prognosis and outcomes of acute tubulointerstitial nephritis.

Summary: This book examines the biology of tuco-tucos (Ctenomys) from an evolutionary perspective. Historically, these subterranean rodents have long attracted the attention of scientists due to its remarkable chromosomes variability and rapid diversification. A wealth of knowledge on physiology, ecology, genetics, morphology, paleontology, and taxonomy has been documented in the last 70 years through numerous single publications. In this volume, expert investigators review and frame these essays with the breadth of current understanding. The collection of chapters are presented into the major topics: i) Evolution of Ctenomys, ii) Geographic Patterns, iii) Organismal Biology, and iv) Environmental Relationships. Given its scope, the book will be of interest to both students and researchers and may stimulate further research with this exciting model on a wide range of evolutionary topics.

Contents:
The history of Ctenomys in the fossil record: a young radiation of an ancient family
A short overview of the systematics of Ctenomys: species limits and phylogenetic relationships
Speciation in the genus Ctenomys: an attempt to find models
Geographical and macroecological patterns of tuco-tucos
Phylogeography and landscape genetics in the subterranean rodents of the genus Ctenomys
Skull shape and size diversification in the Genus Ctenomys (Rodentia: Ctenomyidae)
Biomechanics and strategies of digging
Adaptive pelage coloration in Ctenomys
Environmental and ecological features of the genus Ctenomys
The diet of ctenomyids
Ecological physiology and behavior in the genus Ctenomys
Effects of environmental pollution on the conservation of Ctenomys.

Summary: Jessie Aitkin, the long-time Editor-in-Chief of a leading life sciences journal, receives a fantastic job offer. A young animal rights activist requests an interview with her husband, Peter Dahl, a research scientist at a prestigious institute. An unexpected revelation sets in motion a series of events that shifts the course of their careers and their relationship. In this novel, another page turner by the author of Raw Data: A Novel on Life in Science (Springer 2016), enthusiasm for basic research and for how science is - and could be - communicated combine in a thoughtful reflection on the impact of ambition on personal relationships. In a non-technical appendix, the author discusses the use of narrative in scientific papers and considers alternative modes of science publishing, one of which is featured in the novel. Storytelling in science has the potential to enhance communication, but may also have unintended consequences. This novel and the appendix explore these timely and important issues for the scientific community.

Contents:
Preface
Part I: Tumble Hitch
Part II: On scientific journal publishing.

Summary: Understanding of the molecular mechanisms of tumor development has increased considerably in recent years. As a consequence, the development of targeted therapies has proceeded rapidly, contributing to new drugs against cancer which are now under clinical investigation. Among these new therapies, anti-angiogenic drugs are of particular importance because they can be used against many different types of cancer. This is due to the fact that tumor angiogenesis seems to be involved in most if not all solid metastasizing malignancies. The first part of this book summarizes the knowledge acquired on the molecular entities that play a role in tumor angiogenesis and their mechanisms of action. Furthermore, the identification of molecular markers and their validation as predictive and/or prognostic tools is reviewed. In the second and most important part, the clinical applications of anti-angiogenic treatments are documented for a wide variety of tumors. In particular, the modes of combination with other targeted and/or cytotoxic cancer therapies are presented.

Contents:
Intro; Foreword; Acknowledgments; Contents; About the Editor; Contributors; Part I: Mechanisms of Tumor Angiogenesis; Mechanisms of Tumor Angiogenesis; Introduction; Molecular Mechanisms of Angiogenesis; Mechanisms Involved in Blood Vessel Formation; Vasculogenesis; Sprouting Angiogenesis; Alternative Ways of Blood Supply in Tumors; Intussusception; Vasculogenic Mimicry; Biological Processes Involved in Angiogenesis; Sprouting of Blood Vessels and Endothelial Cell Proliferation; Cues that Guide Vessel Navigation; Vessel Remodeling, Stabilization, and Maturation Endothelial Junctions in Lymphatic and Blood VesselsBlood Flow Regulation: Implication for Basal Sieving; VEGF-Induced Transient Vessel Leakage; Leakage of Molecules; Leakage of Cells; Vascular Leakage in Disease; Vascular Leakage and Cancer; Vascular Leakage and Myocardial Pathology; Vascular Leakage in Ocular Diseases; Lymphatic Neoangiogenesis and Cancer; Imaging Vascular Flow and Integrity; Perspectives; Acknowledgments; Cross-References; References; Benefits and Pitfalls of Tumor Vessel Normalization; Introduction; Lessons and Questions from Anti-VEGF-A/VEGFR2 Therapy Hallmarks of Tumor Vessel NormalizationInducing Tumor Vessel Normalization; Benefits of Tumor Vessel Normalization; Pitfalls of Tumor Vessel Normalization; Translational Implications; Challenges for Clinical Application; Summary; Cross-References; References; The Impact of Endothelial Transcription Factors in Sprouting Angiogenesis; Introduction; Pro-angiogenic Transcription Factors; The ETS Family of Transcription Factors: Essential for Endothelial Cell Development; The cAMP Response Element-Binding Transcription Factors; The GATA Family: Highly Expressed in Endothelial Cells Regression of Blood Vessels and Endogenous Inhibitors of AngiogenesisThe Angiogenic Switch in Tumorigenesis; Hypoxia and Tumor Angiogenesis; Differences between Physiological and Tumor Neovascularization; Differences between Normal and Tumor Vessels; Conclusion; Cross-References; References; The Role of VEGF in Controlling Vascular Permeability; Introduction; Vascular Endothelial Growth Factors (VEGFs) and Their Receptors; Features Regulating Vessel Integrity; Basal Permeability; Endothelial Fenestrations; The Glycocalyx; The Blood-Brain Barrier (BBB); The Vesiculo-Vacuolar Organelle (VVO)

Summary: This book presents the morphology, possible mechanisms of formation, and clinical relevance of tumor deposits (TDs) in different organs and parts of the body. It also describes the diagnostic features that are currently available for TDs and discusses the prognostic impact of TDs. The poor prognostic and predictive values of TDs were found to be as strong as distant metastasis in different series. TDs, best characterized by colorectal cancer, are irregular discrete tumor masses that are discontinuous from the leading edge of the tumor. However, even in colorectal cancers, the place of TDs in tumor staging (tumor, lymph node and distant metastasis categories) remains controversial. This book presents the possible mechanisms of TD formation, including neurotrophic and angiotrophic extravascular migratory metastasis, in comparison with the well-known mechanisms of metastasis. It also shows that TDs were identified in esophageal, gastric, salivary gland, head and neck, and breast carcinomas. The possible mechanisms leading to the frequent association of TDs and peritoneal carcinomatosis are discussed. This is a valuable resource for pathologists, oncologists, and surgeons who are looking for detailed information on the latest scientific insights into the pathology and prognostic implications of TDs.

Summary: This volume will be the first to provide a comprehensive description of tumor dormancy. It will define the clinical and biological aspects of this phenomenon, as well as the cellular and molecular mechanisms associated with tumor dormancy. Chapters will be authored by world-renewed experts who are conducting cutting-edge research in the field. A unique feature will be a conclusive paragraph detailing future development and foreseeable clinical applications at the end of each chapter. The volume will serve as a fundamental instrument for every researcher and clinician interested in the field of tumor dormancy as well as a means of disseminating stimulating concepts and prompting the development of innovative technological solutions.

Contents:
Part 1. Interplay Between Tumor Cells, Stroma and Inflammatory Infiltrate in Regulating Tumor Micro-Environment
Tumor Immuno-Environment in Cancer Progression and Therapy
Cancer Immunotherapy Targets Based on Understanding the T Cell-Inflamed Versus Non-T Cell-Inflamed Tumor Microenvironment
Regulation of CTL Infiltration Within the Tumor Microenvironment
The Role of Tumor Microenvironment in Cancer Immunotherapy
Part 2. Mediators of Tumor Microenvironment
Immunogenic and Non-Immunogenic Cell Death in the Tumor Microenvironment
Exosomes in Cancer: Another Mechanism of Tumor-Induced Immune Suppression
Chemo-immunotherapy: Impact of Indoleamine 2,3-dioxygenase in Defining Immunogenic versus Tolerogenic Cell Death in the Tumor Microenvironment
Targeting Myeloid-Derived Suppressor Cells in Cancer
Tryptophan catabolism and cancer immunotherapy targeting IDO mediated immune Suppression
Part 3. Emerging Targets and Technologies of Modulation of Tumor Microenvironment
Tumor Microenvironment in Cancer Progression and Therapy
The Role of the Immune System and Immunoregulatory Mechanisms Relevant to Melanoma
Oncolytic Virotherapy and the Tumor Microenvironment
The Impact of Housing Temperature Induced Chronic Stress on Preclinical Mouse Tumor Models and Therapeutic Responses: An Important Role for the Nervous Role for the Nervous System
(Immuno)therapeutic Targeting of Tumor-Associated Blood Vessels
Adaptive Resistance to Cancer Immunotherapy
Imaging the Tumor Microenvironment.

Summary: This book is a comprehensive guide to the techniques, clinical applications, and benefits of the different forms of liquid biopsy employed in patients with a variety of tumor types, including lung, breast and colorectal cancer. Offering detailed explanations, it discusses the how changes in tumors can be tracked using these cutting-edge technologies, which enable the detection and analysis of diverse circulating biomarkers: tumor cells, tumor DNA, tumor RNA (free or in exosomes), and fluid biomarkers identifiable by means of targeted proteomics. The use of such advanced technologies is enabling us to tackle questions and problems in a way that was not possible just a few years ago. We now have at our disposal an effective means of overcoming the problem of intratumor heterogeneity, which has limited the value of conventional biopsy approaches. As a consequence, oncology practice is about to change radically, toward truly personalized precision medicine. This book provides both clinicians and researchers with a thorough and up-to-date overview of progress in the field.

Contents:
Circulating Tumor Cells: Pathophysiology of Tumor Cell Release into the Circulation and characterization of CTC
CTC enrichment technologies
Genotyping of CTC :example Lung cancer
CTC in Breast Cancer: a clinical approach
Circulating Tumor DNA: Pathophysiology of ctDNA Release into the Circulation and its characterization
Enrichment and Analysis of ctDNA
ctDNA in Lung Cancer
ctDNA in Breast Cancer
ctDNA in Colorectal Cancer
Dynamic Treatment Stratification using ctDNA
Circulating Tumor RNA: Noncoding Tumor RNAs: Pathophysiology of Release and Techniques of Detection
Circulating miRNAs as Biomarker in Cancer
Plasma Subcompartments as Source for Tumor derived Biomarkers: Exosomes and Vesicles as Biomarker in Cancer
Quantitative proteomic Analysis of Plasma in Cancer.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this book focuses on the role of hematopoietic components of the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include neutrophils, basophils, T helper cells, cytotoxic lymphocytes, fibrocytes, and myeloid-derived suppressor cells, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Hematopoietic Cells - Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Contents:
Neutrophils in the Tumor Microenvironment
Basophils in Tumor Microenvironment and Surroundings
Janus or Hydra: The many faces of T helper cells in the human tumour microenvironment
Cytotoxic CD8+ lymphocytes in the tumor microenvironment
Mucosal-associated invariant T cells in tumors of epithelial origin
Fibrocytes in the Tumor Microenvironment
Models for Monocytic Cells in the Tumor Microenvironment
Myeloid-Derived Suppressor Cells in the Tumor Microenvironment
Index.

Summary: This book addresses the biological processes relevant to the immune phenotypes of cancer and their significance for immune responsiveness, based on the premise that malignant cells manipulate their surroundings through an evolutionary process that is controlled by interactions with innate immune sensors as well as the adaptive recognition of self/non-self. Checkpoint inhibitor therapy is now an accepted new form of cancer treatment. Other immuno-oncology approaches, such as adoptive cell therapy and metabolic inhibitors, have also shown promising results for specific indications. Immune resistance is common, however, limiting the efficacy of immunotherapy in many common cancer types. The reasons for such resistance are diverse and peculiar to the immune landscapes of individual cancers, and to the treatment modality used. Accordingly, approaches to circumvent resistance need to take into account context-specific genetic, biological and environmental factors that may affect the cancer immune cycle, and which can best be understood by studying the target tissue and correlated systemic immune markers. Understanding the major requirements for the evolutionary process governing human cancer growth in the immune-competent host will guide effective therapeutic choices that are tailored to the biology of individual cancers.

Contents:
Preface
Part I: Imaging of tumor microenvironment, In vivo Imaging
New technologies to image tumors
Part II: Immune landscapes and their biology, Systemic correlates of the tumor microenvironment
Adaptive immunity and the tumor microenvironment
The biology of immune active cancers and their regulatory mechanisms
The biology of immune excluded cancers
Immunoscore
Part III: The tumor microenvironment and therapy, The Immune Landscape in Women Cancers
Translational biomarkers, combination therapies and their relationship with immune landscapes
Effects of radiation on the tumor microenvironment
Challenges of CAR T cell therapy for solid tumors.

Summary: Over the past decade, the tumor microenvironment has become one of the most important research areas in cancer biology, as cells within the tumor microenvironment, despite being outnumbered by healthy cells, are able to evade surveillance and immune-mediated destruction. While researchers have learned a great deal about the cellular and structural makeup of the tumor microenvironment, there has been a growing understanding of the metabolic interplay between the tumor microenvironment's various cellular constituents and how each of them contributes to overall tumor growth and metastases. This new volume will guide researchers, students, oncologists and academics through a rapidly developing and changing field with a thorough understanding of tumor microenvironment biology from a cellular, structural, metabolic, and immunological perspective.

Contents:
1. Inflammatory components of the thyroid cancer microenvironment - an avenue for identification of novel biomarkers
2. Disruption of Cell-Cell Communication in Anaplastic Thyroid Cancer as an Immunotherapeutic Opportunity
3. Exosomes in the Healthy and Malignant Bone Marrow Microenvironment
4. Structural Biology of the Tumor Microenvironment
5. Metabolic interactions between tumor and stromal cells in the Tumor Microenvironment
6. Interacting Genetic Lesions of Melanoma in the Tumor Microenvironment: Defining a Viable Therapy
7. Non-coding RNAs in Papillary Thyroid Cancer: Interaction with cancer associated fibroblasts (CAFs) in the Tumor Microenvironment (TME) and regulators of differentiation and Lymph Node Metastasis.

Summary: This book provides a comprehensive overview of the latest research on the molecular players in the tumor microenvironment, including Cathepsin D, galectins, iron, oxygen, Phospholipase D1, leptin, extracellular vesicles, and more. Taken alongside its companion volumes, these books update us on what we know about the tumor microenvironment as well as future directions. Tumor Microenvironment: Molecular Players - Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this volume focuses on non-hematopoietic cells within the tumor microenvironment. Further, it teaches readers about the roles of distinct constituents of the tumor microenvironment and how they affect cancer development. Topics include fibroblasts, adipocytes, mesenchymal stem cells, stellate cells, and more. Taken alongside its companion volumes, Tumor Microenvironment: Non-Hematopoietic Cells updates us on what we know about the different aspects of the tumor microenvironment as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists focused in the tumor microenvironment and how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. All of the chapter authors are renowned international experts in the cancer biology field in specific subfields that will be the focus of their chapters.

Summary: This volume discusses novel concepts in cancer biology, focusing on different factors that affect the tumor microenvironment. Topics covered include sex-based differences in the tumor microenvironment, dormancy in the tumor microenvironment, the influence of obesity on the tumor microenvironment, and much more. Taken alongside its companion volumes, Tumor Microenvironment: Novel Concepts covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Contents:
1. The Tumour Microenvironment and Circulating Tumour Cells: A partnership driving metastasis and glycan-based opportunities for cancer control
2. Dormancy in the Tumor Microenvironment
3. Tumor-associated tertiary lymphoid structures: A cancer biomarker and a target for next-generation immunotherapy
4. Studying the tumor microenvironment in zebrafish
5. Pre-metastatic niche formation by neutrophils in different organs
6. Tumor cell invasion and the tumor microenvironment: Special focus on brain tumors
7. The dog as a model to study the tumor microenvironment
8. EFFEROCYTOSIS AND THE STORY OF FIND ME, EAT ME AND DONT EAT ME SIGNALING IN THE TUMOR MICRO ENVIRONMENT
9. Color-coded imaging of the tumor micro-environment (TME) in human patient-derived orthotopic xenograft (PDOX) mouse models
10. Mitochondria and the tumor microenvironment in blood cancer
11. Telocytes in the tumor microenvironment
12. Modeling the roles of astrocytes in the metastatic tumor cell microenvironment
13. Roles of fibroblasts in microenvironment formation associated with radiation-induced cancer
14. Tumor microenvironment-associated pericyte populations may impact therapeutic response in thyroid cancer
15. The adrenergic nerve network in cancer
16. Current treatment modalities targeting tumor microenvironment in castration-resistant prostate cancer
17.Brain metastases and tumor microenvironment
18. MIGRATION STIMULATING FACTOR (MSF). ITS ROLE IN THE TUMOUR
MICROENVIRONMENT
19. Mechanical Signaling in the Mammary Microenvironment - from Homeostasis to Cancer
20. Osteopontin Signaling in Shaping Tumor Microenvironment Conducive to Malignant Progression
21. Progesterone receptor signaling in the breast tumor microenvironment
22. Progranulin/GP88, a complex and multi-faceted player of tumor growth by direct action and via the tumor microenvironmen
23. Sex-based differences in the tumor microenvironmet.

Summary: This volume discusses recent research advances in cancer biology, focusing on the role of the tumor microenvironment. Taken alongside its companion volumes, Tumor Microenvironment: Recent Advances covers the latest research on various aspects of the tumor microenvironment, as well as future directions. Useful for introducing the newer generation of researchers to the history of how scientists studied the tumor microenvironment as well as how this knowledge is currently applied for cancer treatments, it will be essential reading for advanced cell biology and cancer biology students, as well as researchers seeking an update on research on the tumor microenvironment.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on how different signaling pathways are important in the tumor microenvironment. Multiple signaling pathways are covered, including S1P, neuregulin, Notch, erythropoietin, Rho-ROCK, mTOR, and more. Taken alongside its companion volumes, these books update us on what we know about various aspects of the tumor microenvironment as well as future directions. Tumor Microenvironment: Signaling Pathways - Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research in the field. A variety of topics are covered, including metabolism in the tumor microenvironment, stellate cells and endothelial progenitors in the tumor microenvironment, as well as the effects of HIV, viral hepatitis, and inflammation in the tumor microenvironment, and more. Taken alongside its companion volumes, Tumor Microenvironment: State of the Science updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Contents:
Metabolism in the tumor microenvironment
Neutrophil Elastase and Neutrophil Extracellular Traps in the Tumor Microenvironment
Viral hepatitis, inflammation, and tumour microenvironment
Effects of HIV on the tumor microenvironment
GLI2-mediated inflammation in the tumor microenvironment
Stellate Cells in the Tumor Microenvironment
Endothelial Progenitors in the Tumor microenvironment
Chimeric antigen receptors for the tumour microenvironment
Toll-Like Receptors (TLRs) in the Tumor Microenvironment (TME): A dragon-Like Weapon in a Non-Fantasy Game of Thrones
Multiple dynamics in tumor microenvironment under radiotherapy
Index.

Summary: This book will allow readers to discover the crucial role of tumor microenvironment (TME) in the selection of cancer cells that are more prone to carry on cancer initiation and progression. The metabolic remodeling, as the basis of life overall, allows the adaptive establishment of a tumor in a certain TME, which in turn presents a variety of selective pressures. Coupled with the late diagnosis, the poor therapy response are the main hurdles limiting oncological disease control and eventual cure. Thus the metabolic plasticity of cancer cells often underlies chemoresistance. This edited work presents an exhaustive description and comprehensive view of cancer metabolism as a weapon used by cancer cells to adapt to TME. TME and the organ microenvironment is analyzed as a whole, considering cancer cells, stromal cells and microbiota. This complex circuit is observed as the support for disease development and therapy evasion but also as a valuable kernel, presenting new players to be targeted in a more precise cancer therapy. The various threads of cancer biology related to TME and metabolic adaptation will be addressed including: 1) key players in the metabolic network; 2) the way adaptive metabolic features are sustained by TME; 3) TME and metabolic signaling, accounting for cancer cells survival; 4) metabolic fitness driven limitations in therapy response, and 5) the way TME and cancer metabolism can be helpful in the design of new drugs. In addition, the usefulness, technical strengths and weaknesses of analytical techniques useful in cancer metabolomics will be presented in an integrative way. Moreover, the use of innovative and traditional in vitro and in vivo cancer models, as powerful tools to address the influence of TME in cancer progression and metabolic reprogramming will be also presented. This work was written by experts and dedicated to researchers with interests in cancer biology, TME, cancer metabolism and therapy. It will interest the Advances in Experimental Medicine and Biology readership, including basic researchers, analytic researchers, bio-engineers and clinicians.

Contents:
Preface
Tumor microenvironment a job of several holders
Tumor microenvironment- a selective pressure boosting cancer
Lactate and lactate transporters as key players in the maintenance of the Warburg effect
Section 1. Adaptive metabolic features are sustained by tumor microenvironment
Recycling the interspecific relations with epithelial cells: bacteria and cancer metabolic symbiosis
Gut microbiota and cancer of the host: colliding interests
Metabolic plasticity of tumor cells: how they do adapt to food deprivation
Multifaceted oncogenic role of adipocytes in the tumour microenvironment
Endothelial cells (ECs) metabolism a valuable piece to disentangle cancer biology
Monocytes and macrophages in cancer: unsuspected roles
Section 2. Microenvironment and metabolic signalling- the way cancer cells know how to survive.-: Wnt signaling: paths for cancer progression
Microenvironment driven metabolic adaptation in melanoma
Metabolic reprogramming and signaling to chromatin modifications in tumorigenesis
Inflammatory microenvironment modulation of alternative splicing in cancer: a way to adapt
The bone marrow niche
the tumor microenvironment that ensures leukemia progression
Section 3. Metabolic fitness and therapy response in cancer
Exploiting cancer cells metabolic adaptability to enhance therapy response in cancer
The metabolic remodelling in lung cancer and its putative consequence in therapy response
Hydrogen sulfide metabolism and signaling in the tumor microenvironment
Using metabolic adaptation to design new drugs
Metabolomics- a new way of screening cancer
NMR as a tool for metabolomics
Section 5. Animal models- addressing cancer microenvironment
Animal models to study cancer and its microenvironment
Modulating the metabolic phenotype of cancer microenvironment
Modeling of Solid-tumor Microenvironment in Zebrafish (Danio Rerio) Larvae
Section 6. In vitro and ex vivo cancer models
In vitro and ex vivo models- the tumor microenvironment in a flask
Index.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the role of interleukins in the tumor microenvironment. Each chapter focuses on the various ways to target the tumor microenvironment by intervention in the interleukin biology, including IL-1, IL-8, IL-21, IL-36 signaling, and more. Taken alongside its companion volumes, Tumor Microenvironment: The Role of Interleukins - Part A updates us on what we know about various aspects of the tumor microenvironment, as well as future directions. This book is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment. -- Provided by publisher.

Contents:
IL-1 signaling in tumor microenvironment / Weizhou Zhang, Nicholas Borcherding, Ryan Kolb
Interleukin-8 in the tumor immune niche : lessons from comparative oncology / Jong-Hyuk Kim
IL-9 and Th9 cells in tumor immunity / Ying He, Lin Dong, Yejin Cao, Yujing Bi, Guangwei Liu
IL-17 signaling in the tumor microenvironment / R.M. Gorczynski
Emerging roles for interleukin-18 in the gastrointestinal tumor microenvironment / Ka Yee Fung, Paul M. Nguyen, Tracy L. Putoczki
IL-21 signaling in the tumor microenvironment / Ghita Chabab, Nathalie Bonnefoy, Virginie Lafont
ST2 signaling in the tumor microenvironment / Chih-Peng Chang, Meng-Hsuan Hu, Yu-Peng Hsiao, Yi-Ching Wang
IL-36 signaling in the tumor microenvironment / Manoj Chelvanambi, Aliyah M. Weinstein, Walter J. Storkus.

Summary: The collection of chapters in this proceeding volume reflects the latest research presented at the Aegean meeting on Tumor Microenvironment and Cellular Stress held in Crete in Fall of 2012. The book provides critical insight to how the tumor microenvironment affects tumor metabolism, cell stemness, cell viability, genomic instability and more. Additional topics include identifying common pathways that are potential candidates for therapeutic intervention, which will stimulate collaboration between groups that are more focused on elucidation of biochemical aspects of stress biology and groups that study the pathophysiological aspects of stress pathways or engaged in drug discovery.

Contents:
Hypoxia and metabolism in cancer
Hypoxia and Regulation of Cancer Cell Stemness
Hypoxia-mediated metastasis
Escape Mechanisms from Antiangiogenic Therapy: An Immune Cells Perspective
Hypoxic VDAC1: a potential mitochondrial marker for cancer therapy
Hypoxia directed drug strategies to target the tumor microenvironment
Radiotherapy and the Tumor Microenvironment: Mutual Influence and Clinical Implications
Autophagy and cell death to target cancer cells: exploiting synthetic lethality as cancer therapeutic
Intratumoral Hypoxia as the Genesis of Genetic Instability and Clinical Prognosis in Prostate Cancer
miR-210: Fine-Tuning the Hypoxic Response
The role of complement in tumor growth
Imaging angiogenesis, inflammation and metastasis in the tumor microenvironment with magnetic resonance imaging.

Summary: Revealing essential roles of the tumor microenvironment in cancer progression, this book provides a comprehensive overview of the latest research on the tumor microenvironment in over thirty human organs, including the parathyroid gland, heart, intestine, testicles, and more. Taken alongside its companion volumes, these books update us on what we know about the different aspects of the tumor microenvironments in distinct organs as well as future directions. Tumor Microenvironments in Organs: From the Brain to the Skin - Part A is essential reading for advanced cell biology and cancer biology students as well as researchers seeking an update on research in the tumor microenvironment.

Summary: "Tumors and cancers are insidious diseases characterized by an abnormal growth of cells that extend beyond their usual boundaries and disrupt the normal functions of affected organs. Forming the first of the four volumes devoted to tumors and cancers, this volume focuses on the central and peripheral nervous systems. Each chapter presents a state of the art summary of tumor/cancer of a particular type in relation to its definition, biology, epidemiology, disease mechanism/pathogenesis, clinical signs, diagnosis, treatment and prognosis."--Provided by publisher.

Summary: This updated second edition of a successful book provides essential, internationally applicable information in the area of bone and joint pathology with emphasis on practical diagnostic aspects, including many illustrations: roentgenograms, CT-scans, MRI, scintigraphies, as well as pictures of gross surgical specimens and microphotographs, immunohistochemical reactions and genomics. Information on histopathological and molecular diagnosis, and basic therapeutic guidelines are provided. This book offers generous coverage of epidemiology, clinical features, radiology, pathology, differential diagnosis, prognosis and treatment, not only for common lesions, but also for those less frequently encountered, including lesions of joints. The content is arranged based on the World Health Organization's Consensus Classification, with the addition of other lesions not included therein. Tumors and Tumor-Like Lesions of Bone provides day-to-day assistance to general and specialized surgical pathologists, radiologists, orthopedic, head and neck and dental surgeons, oncologists and rheumatologists. .

Contents:
Part I Introduction
Practical Approach to the Diagnosis of Bone Tumors
Special Clinical Aspects of Certain Bone Tumors and Tumor-like Lesions
An Imaging Approach to Bone Tumors
Methods of Bone Biopsy
Basic and Ancillary Techniques in Bone Pathology
Grading and Staging
Basic Guidelines on the Oncologic Treatment of Malignant Tumors of Bone
Surgical Treatment of Tumors and Tumor-like Lesions of Bone
Part II Bone-Forming Tumors
Medullary Osteoma
Parosteal Osteoma
Osteoid Osteoma
Osteoblastoma
Conventional Central Osteosarcoma
Parosteal Osteosarcoma
Periosteal Osteosarcoma
High-Grade Surface Osteosarcoma
Part III Cartilage-Forming Tumors
Enchondroma
Multiple Enchondromatosis (Ollier's Disease)
Periosteal Chondroma
Osteochondroma
Multiple Osteochondromatosis
Chondroblastoma
Chondromyxoid Fibroma
Chondrosarcoma
Chondrosarcoma Variants
Part IV Giant Cell Tumor
Giant Cell Tumor of Bone
Part V Round Cell Tumors
Ewing's Sarcoma Family of Tumors
Lymphoma of Bone
Myeloma
Part VI Fibrous Tumors
Desmoplastic Fibroma of Bone
Fibrosarcoma of Bone
Part VII Fibrohistiocytic Tumors
Benign Fibrous Histiocytoma of Bone
Malignant Fibrous Histiocytoma of Bone
Part VIII Vascular Tumors
Hemangioma
Epithelioid Hemangioma
Glomus Tumor
Epithelioid Hemangioendothelioma
Angiosarcoma
Part IX Adamantinoma
Adamantinoma
Part X Notochordal Tumors
Benign Notochordal Cell Tumor
Chordoma
Part XI Leiomyosarcoma
Leiomyosarcoma of Bone
Part XII Adipocytic Tumors
Lipoma of Bone
Liposarcoma of Bone
Part XIII Neurogenic Tumors
Schwannoma of Bone
Neurofibroma of Bone
Part XIV Phosphaturic Mesenchymal Tumor
Phosphaturic Mesenchymal Tumor
Part XV Metastatic Carcinoma Involving Bone
Metastatic Bone Carcinoma. .

Contents:
Includes bibliographical references and index. Introduction
Bone-forming tumors
Cartilage-forming tumors
Giant cell tumor
Round cell tumor
Fibrous tumors
Fibrohistiocytic tumors
Vascular Tumors
Adamantinoma
Notochordal tumors
Leiomyosarcoma
Adipocytic tumors
Neurogenic tumors
Phosphaturic mesenchymal tumor
Metastatic carcinoma involving bone
Tumor-like lesions and other conditions that simulate primary tumors.

Contents:
Epidemiology of adolescents and young adults with cancer in Europe / Desandes, E.; Stark, D.P
Supportive care / Olsen, P.R.; Lorenzo González, R
Long-term follow-up and survivorship / Tsirou, A.; Hjorth, L
Increasing access to clinical trials and innovative therapy for teenagers and young adults with cancer
a multiple stakeholders and multiple steps process / Gaspar, N.; Fern, L
Collaboration and networking / Husson, O.; Manten-Horst, E.; van der Graaf, W.T.A
Adult cancers in adolescents and young adults / Laurence, V.; Marples, M.; Stark, D.P
Pediatric cancers and brain tumors in adolescents and young adults / McCabe, M.G.; Valteau-Couanet, D
Leukemia / Juliusson, G.; Hough, R
Lymphoma in adolescents and young adults / Brugires, L.; Brice, P
Germ cell tumors in adolescents and young adults / Calaminus, G.; Joffe, J
Sarcomas of soft tissue and bone / Ferrari, A.; Dirksen, U.; Bielack, S.

Contents:
Vol. 1. Gliomas: Glioblastoma (part 1)
Vol. 2. Gliomas: Glioblastoma (part 2)
Vol. 3. Brain tumors (part 1)
Vol. 4. Brain tumors (part 2)
Vol. 5. Astrocytomas, hemangioblastomas, and gangliomas
Vol. 6. Spinal Tumors (Part 1)
Vol. 7. Meningiomas and Schwannomas
Vol. 8. Astrocytoma, Medulloblastoma, Retinoblastoma, Chordoma, Craniopharyngioma, Oligodendroglioma, and Ependymoma --Vol. 9. Lymphoma, supratentorial tumors, glioneuronal tumors, gangliogliomas, neuroblastoma in adults, astrocytomas, ependymomas, hemangiomas, and craniopharygiomas
Vol. 10. Pineal, pituitary, and spinal tumors
Vol. 11. Pineal, pituitary and, spinal tumors
Vol. 12. Molecular mechanisms, children's cancer, treatments, and radiosurgery
Vol. 13. Types of tumors, diagnosis, ultrasonography, surgery, brain metastasis, and general CNS diseases
Vol. 14. Glioma, meningioma, neuroblastoma, and spinal tumors

Summary: Like the ten preceding volumes in the series Tumors of the Central Nervous System, this book is distinguished for its comprehensive approach, its distinguished roster of some 93 contributors representing 8 different countries and its embrace of leading-edge technology and methods. Volume 11: Pineal, Pituitary, and Spinal Tumors concentrates on the diagnosis, prognosis and therapy of four types of tumors, namely Glioblastoma, Meningioma, Schwannoma and Spinal Tumors. The book offers an in-depth survey of a range of new technologies and their applications to tumor diagnosis, treatment and therapy assessment. The contributors explain in thorough detail a range of current and newly developed imaging methods, including molecular imaging and PET scan. Also covered is molecular profiling of brain tumors to select therapy in clinical trials of brain tumors. Discussion includes a review of such surgical treatments as resection and the application of non-invasive stereotactic radiosurgery for treating high-risk patients with brain metastasis. Additional discussion is devoted to tumor seeding.

Contents:
Part I. Imaging. An introduction to brain tumor imaging / Amit Mehndiratta [and 4 others] ; Molecular imaging of brain tumors / Nora Sandu, Toma Spiriev, and and Bernhard Schaller ; Use of 11c-4dst-pet for imaging of human brain tumors / Tadashi Nariai [and 3 others]
Part II. Glioma and glioblastoma. Diffusion tensor magnetic resonance imaging-based tractography for glioma surgery / Shiro Ohue [and 3 others] ; Angiocentric glioma, pilomyxoid astrocytoma, and Pituicytoma: new entities in the world health organization classification / Jamie L. Odem and Douglas C. Miller ; Diffuse intrinsic pontine gliomas in children: treatment (an Update) / Amy Lee Bredlau and David N. Korones ; Gliomatosis cerebri: implications of genetic findings / Marcel Seiz and Christian Hartmann ; Impact of bevacizumab chemotherapy on glioblastomas / Brandyn A. Castro and Manish K. Aghi ; Glioblastoma microvesicles transport RNA and proteins Promoting tumor growth / David Gonda [and 4 others] ; MicroRNA in the pathophysiology of glioblastoma / Jessian Munoz, Steven J. Greco, and Pranela Rameshwar ; Surgical management of incidental low-grade gliomas / Johan Pallud and Emmanuel Mandonnet
Part III. Stereotactic radiosurgery. Stereotactic radiosurgery for the treatment of brain metastases / Emmanouil Fokas ; Local control of low-volume brain metastases using stereotactic radiosurgery / Howard Hsu [and 3 others] ; Tumor seeding after stereotactic brain biopsy / Gordan Grahovav ; Intracranial stereotactic radiosurgery in high risk patients with metastases from radioresistant primary tumors / Varun Kumar Chowdry and Seung Shin Hahn ; Brain metastases: treatment with stereotactic iodine-125 brachytherapy / Maximilian I. Ruge, Philipp Kickingereder, and Harald Treuer ; Stereotactic radiosurgery for skull base meningiomas / Daniel M.S. Raper, Robert M. Starke, and Ricardo J. Komotar
Part IV. Spinal cord tumors. Pediatric spinal cord tumors / Chiazo Amene, Michael Levy, and John Crawford ; Radiosurgery for intramedullary spinal cord tumors / Anand Veeravagu [and 3 others] ; Novalis spinal radiosurgery / David Ly, Christopher J. Anker, and Meic H. Schmidt ; Etiology and outcomes of pediatric spinal cord tumors / Susan Biffl
Part V. Meningioma. Selection of elderly meningioma patients for surgery using a Clinical-radiological grading system as a predictor of outcome / Manuela Caroli [and 5 others] ; Cranial meningioma in neurofibromatosis type 2 patients: role of mutations / Miriam J. Smith and D. Gareth R. Evans ; Classification of meningioma using immunogenic antigens / Nicole Ludwig ; Treatment of benign meningiomas using radiosurgery / Antonio Santacroce [and 5 others] ; Necrotic rhabdoid meningiomas: histopathological diagnosis / Ewa Matyja and Wiesława Grajkowska
Part VI. Schwannomas. Multiple schwannomas: diagnosis and treatment / Takashi Eguchi [and 9 others] ; Treatment of patients with vestibular schwanommas using gamma knife radiosurgery / Toshinori Hasegawa ; Schwannomas in the craniocervical region: complete surgical removal / Zaman Mirzadeh and Robert F. Spetzler ; Cranial base surgery of hypoglossal schwannomas / Yoichi Nonaka and Takanori Fukushima
Index.

Contents:
Classification/Diagnosis of Brain Tumors Using Discriminant Function Analysis
Neuronal Differentiation in the Adult Brain: CDK6 as the Molecular Regulator
Prolactinomas: Role of VEGF, FGF-2 and CD31
Human Brain Tumor Growth: Role of Aquaporins
Molecular and Functional Characterization of Human Adipocytes
Inhibition of Neuroblastoma Progression by Targeting Lymphangiogenesis: Role of an Endogenous Soluble Splice-Variant of VEGFR-2
Hyperinsulinemia Tends to Induce Growth Without Growth Hormone in Children with Brain Tumors After Neurosurgery
Childhood Brain Tumours: Proton Beam Therapy
Pathogenesis of Medulloblastoma: Role of Molecular Genetic Alterations
Medulloblastomas: Survival Differences Between Children and Adults
Survivors of Childhood Cancer: Risk of Glioma and Meningioma Following Radiotherapy
Survivors of Childhood Cancer: Risk of New Primary Neoplasms of the CNS
Brain Tumor Typing and Therapy Using Combined Ex Vivo Magnetic Resonance Spectroscopy and Molecular Genomics
Atlas-Based Segmentation of Tumor-Bearing Brain Images
Nonthermal Irreversible Electroporation as a Focal Ablation Treatment for Brain Cancer
The Role of Whole Brain Radiation Therapy for Metastatic Brain Tumors
Craniotomy for Intracranial Tumors: Role of Postoperative Hematoma in Surgical Mortality
Pituitary Adenomas: Treatment Using the Endonasal Approach
Intracranial Tumors: Treatment with Endoscopic Neurosurgery
Incidence of Recraniotomy for Postoperative Infections After Surgery for Intracranial Tumors
Transsphenoidal Surgery for Non-Adenomatous Tumors: Effect on Pituitary Function
Treatment of Brain Tumors: Electrochemotherapy
Comparison of Navigated Transcranial Magnetic Stimulation to Direct Electrical Stimulation for Mapping the Motor Cortex Prior to Brain Tumor Resection
The Role of Glutathione and the Glutathione-Linked Enzyme Systems in Brain Tumor Drug Resistance
Drugs for Primary Brain Tumors: An Update
Neurosurgical Treatment for Brain Metastases: Clinical Features, Operative Strategies, Recurrence and Survival
Image-Guided Radiosurgery for Hypothalamic Hamartomas
Image-Guided Stereotactic Radiosurgery for Spinal Pathology
Image-Guided Stereotactic Radiosurgery for Optic Nerve Sheath Meningiomas
Brain Metastases: The Application of Stereotactic Radiosurgery and Technological Advances
Treatment of Chordomas by Stereotactic Radiosurgery with a Linear Accelerator: Comparison with Other Modes.

Summary: Volume 13: Pineal, Pituitary, and Spinal Tumors is organized in six sections, for convenience and quick access to critical information. Section I, Types of Tumors includes a chapter on molecular characterization of Embryonal tumors, a chapter on diagnosis of metastatic oligodendroglioma using fine-needle aspiration cytology, one covering intra-arterial chemotherapy of oligodendroglial tumors and another on the role of cyclooxygenase-2 in the development and growth of Schwannomas, and others, closing with a chapter on trigeminal neuralgia with cerebellopontine angle tumors. Section II, Diagnosis, includes two chapters on cell counting in histopathologic slides of tumors. Section III offers three chapters which discuss aspects of intraoperative ultrasonography. Section IV covers brain tumor surgery, and Section V surveys Brain Metastasis. The final section offers a wide-ranging review of General Diseases, with chapters on, among others, Alexander Disease; Lipoma; Transplantation of human umbilical cord blood mononuclear cells in cases of neonatal hypoxic-ischemic brain damage; and a chapter discussing the use of mobile phones and brain cancer risk in children. Like its twelve predecessors in the series, this volume merits distinction for its thorough approach, its roster of 78 distinguished contributors representing 14 different countries and its detailed examination of leading-edge technology and methods.

Contents:
Part I. Types of tumors
part II. Diagnosis
part III. Ultrasonography
part IV. Surgery
part V. Brain metastasis
part VI. General CNS diseases.

Summary: This book covers all aspects of the diagnosis and treatment of tumors of the jugular foramen - cranial base lesions that present particular diagnostic and management difficulties and remain challenging to remove despite advances in surgery and interventional neuroradiology. The authors have developed novel concepts and surgical techniques relating to management of the facial nerve, reconstruction of the cranial base, and resection of large tumors with intra- and extracranial extension. These techniques, as well as anatomic studies in cadavers, are presented by means of surgical photographs, illustrations, and videos. Tumors of the Jugular Foramen will be of interest to all specialists involved in the management of these challenging tumors, including neurosurgeons, ENT surgeons, neuroradiologists, neurologists, neurointensivists, radiotherapists, oncologists, and physiotherapists.

Contents:
1. Introduction
2. Historical Aspects
3. Epidemiology and Genetics and Pattern of Spread
4. Natural History, Clinical symptoms and Classifications
5. Surgical Anatomy
6. Radiological Diagnosis
7. Evidence-Based Treatment, Surgical Indications, Contra-indications, Preoperative Clinical Evaluation, Preoperative Preparation for Anesthesia
8. Preoperative Embolization
9. Surgical Treatment and Postoperative Management
10. Histopathological Findings
11. Radiation Therapy and Radiosurgery
12. Chemotherapy
13. Surgical Results and Conclusions.

Summary: "Covering tumors of the nose, sinuses, and nasopharynx for the first time in a single volume, this book is essential for all specialists. It incorporates the newest techniques for evaluation and treatment, including endoscopic approaches to the skull base, and offers a wealth of evidence-based data and analysis. For all members of the multidisciplinary health care teams who manage these complex cases, this book makes a major contribution to the field. Special features: Written by three international authorities who have published and lectured widely and conducted landmark studies in this area, Covers the full range of benign and malignant nose and sinus tumors, as well as the specific nasopharyngeal tumors that are more common to certain geographic regions (Far East) and ethnic groups (Chinese origin), Content is based on one of the largest single institutional studies ever undertaken, plus an extensive review of the international literature, Encompasses every aspect of the field, from etiology, clinical features, histology, imaging studies, and diagnosis to natural history, treatment options, outcomes, and management of residual or recurrent disease, Includes up-to-date contributions from experts on chemoradiation and head and neck imaging. With the goal of centralizing data and long-term follow-up, this comprehensive guide is invaluable for all otolaryngologists, head and neck surgeons, oncologists, neurosurgeons, and maxillofacial and plastic surgeons who treat patients with challenging sinonasal, skull base, and nasopharyngeal neoplasms"--Provided by publisher.

Contents:
PART 1: GENERAL ASPECTS: Surgical Anatomy of the Sacrum
Clinical and Neurologic Manifestations of Sacral Lesions
Epidemiology
Diagnostic Imaging
Staging and Biopsy
Histopathology
PART 2: BENIGN LESIONS: Giant Cell Tumor
Osteoblastoma
Osteoid osteoma
Aneurysmal bone cyst
Scwannoma
Exostosis
Hemangioma
Other benign rare entities
PART 3: MALIGNANT LESIONS: Metastasis
Chordoma
Osteosarcoma
Ewing's Sarcoma
Myeloma
Lymphoma
Condrosarcoma
Other malignant rare entities
PART 4: TREATMENTS: Surgical Approaches to the Sacrum
Partial and total sacrectomy
Sacral Biomechanics and Reconstruction
Soft tissue reconstruction after sacral surgery
Embolization of Sacral Lesions
Radiation Therapy of Sacral Neoplasms.

Contents:
Specimen evaluation
Nonmalignant fibroblastic and myofibroblastic tumors and tumor-like lesions
Fibroblastic/myofibroblastic neoplasms with variable biologic potential
Lipomatous tumors
Smooth muscle tumors
Tumors with skeletal muscle differentiation
Vascular tumors
Soft tissue tumors with cartilaginous or osseous differentiation
Soft tissue tumors with epithelial differentiation
Miscellaneous translocation sarcomas
Miscellaneous tumors
Cytopathology of soft tissue tumors and tumor-like lesions.

Summary: This book presents a focused, case-oriented approach to a specific disease entity: tumors located within the spinal canal. Each tumor type constitutes its own chapter and additional chapters focus on more novel trends in the field, such as radiosurgery and minimally invasive surgical techniques. In each chapter, the authors provide expert opinions on preoperative goals, intraoperative techniques and decision-making, and postoperative paradigms, including surveillance guidelines and thresholds for initiating adjuvant therapy. The management of intradural tumors has become increasingly interdisciplinary, and one of the major goals of this text is to familiarize the treating neurosurgeon with the latest advances in both operative and non-operative strategies. The text seeks to answer two questions: 1) what are the detailed surgical steps taken by these neurosurgeons to ensure safe maximal resection of these tumors? and 2) in cases of residual and recurrent disease, what are the most effective management options? Consensus regarding definitive management remains difficult to reach given the overall rarity of these tumors. Tumors of the Spinal Canal is ultimately a practical reference drawn from the experiences of its individual authors, a compendium of surgical pearls, pitfalls, and preferences, all steeped in the most recent and relevant literature on the subject. .

Contents:
Schwannoma
Meningioma
Myxopapillary Ependymoma and Rare Tumors
Ependymoma
Astrocytoma
Hemangioblastoma
Metastases
Radiation for Extramedullary Tumors
Radiation for Intramedullary Tumors
Minimally Invasive Surgery for Intradural Tumors.