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  • 2005 Springer
    Brint, Elizabeth; O'Neill, Luke A. J.
    Also available: Print – 2005
  • 2008 Springer
    Akira, Shizuo; Bauer, Stefan; Hartmann, Gunther.
  • 2014 CRCnetBASE
    Glick, Stephen; Reiser, Ingrid.
    "Preface For much of the past century, projection radiography has been the workhorse in the diagnostic imaging clinic. Tomosynthesis, which introduces depth information to the x-ray radiographic image with little or no increase in radiation dose, could potentially replace projection radiography as we move into the twenty-first century. This book, Tomosynthesis Imaging, offers the most comprehensive resource to date for this new emerging imaging technology. Digital tomosynthesis imaging is a novel quasi-three dimensional x-ray imaging modality that has been primarily developed during the past two decades, owing to the availability of large-area digital x-ray detectors. The tomosynthesis image is reconstructed from a sequence of projection images that are acquired from a limited angle x-ray scan, therefore, conceptually, tomosynthesis might be considered as limited-angle CT. Because of the limited angle acquisition, resolution in the reconstructed volume is not isotropic. The resolution in image planes parallel to the detector surface is similar to the native detector resolution, but the resolution perpendicular to the detector surface direction is substantially worse, and depends on the scan arc length and on the size of the detail being imaged. Tomosynthesis imaging is being actively investigated for use in a variety of clinical tasks. Currently, tomosynthesis breast imaging is at the forefront, having received approval for clinical use in Europe and Canada in 2008, and FDA approval in the United States in 2011. Although conventional mammography has been very successful in reducing the breast cancer mortality rate, its sensitivity and specificity are less then desirable, especially for women with dense breast tissue"--Provided by publisher.
  • 2016 Karger
    Kantarci, Alpdogan; Will, Leslie; Yen, Stephen.
    Section 1. Biology and metabolism of alveolar bone -- Section 2. Mechanical properties of dentoalveolar structures -- Section 3. Orthodontic tooth movement -- Section 4. Methods to facilitate orthodontic tooth movement.
  • 2013 Karger
    Loveren, Cor van.
    An introduction to toothpaste : its purpose, history, and ingredients / Lippert, F. -- Fluorides and non-fluoride remineralization systems / Amaechi, B.T., van Loveren, C. -- Antiplaque and antigingivitis toothpastes / Sanz, M., Serrano, J.; Iniesta, M.; Santa Cruz, I., Herrera, D. -- The role of toothpastes in oral malodor management / Dadamio, J., Laleman, I., Quirynen, M. -- Anti-calculus and whitening toothpastes / van Loveren, C., Duckworth, R.M. -- The role of toothpaste in the aetiology and treatment of dentine hypersensitivity / Addy, M., West, N.X. -- Toothpaste and erosion / Ganss, C., Schulze, K., Schlueter, N. -- Abrasivity testing of dentifrices : challenges and current state of the art / González-Cabezas C., Hara, A., Hefferren, J., Lippert, F. -- Laboratory and human studies to estimate anticaries efficacy of fluoride toothpastes / Tenuta, L.M.A., Cury, J.A. -- Pharmacokinetics in the oral cavity : fluoride and other active ingredients / Duckworth, R.M. -- After-brush rinsing protocols, frequency of toothpaste use : fluoride and other active ingredients / Parnell, C., O'Mullane, D.
  • 2015 Thieme-Connect
    O'Brien, William T.
    Congenital and developmental -- Attenuation and signal abnormality -- Masses and masslike lesions -- Vasculature and cerebrospinal fluid spaces -- Calvarium and skull base -- Temporal bone -- Sinonasal -- Maxillofacial -- Neck (including spaces) -- Orbits.
  • 2010 Thieme Book
    O'Brien, William T.
    Chest and cardiac imaging -- Gastrointestinal imaging -- Genitourinary imaging -- Musculoskeletal imaging -- Head and neck imaging -- Brain and spine imaging -- Pediatric imaging -- Ultrasound imaging -- Fetal imaging -- Vascular and interventional radiology -- Nuclear medicine -- Breast imaging -- Roentgen classics.
  • O'Brien, William T.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Wiley
    McLoughlin, John.
    Expert urologists give their personal insight into the best methods of overcoming a variety of scenarios that occur during urologic surgery, randing from how to best salvage specific difficult intra-operative problems, to simplifying complex procedures, or tips advising on how best to clarify diagnosis.
  • 2011 Karger
    Elsner, Peter; Farage, Miranda A.; Surber, Christian.
    Mucosal membranes have unique anatomical and physiological properties -- differing from those of the keratinized epithelium -- which affect drug or chemical absorption. This makes the diagnosis and treatment of diseases of the mucosa a challenge to dermatologists as well as gynecologists, since many conditions are difficult to recognize and well-established principles of skin disease treatment do not apply to the mucosa. This volume is exclusively devoted to the mucosal membrane and delivers a better understanding of this distinctive area. Subsequently to introductory chapters on the morphology and physiology of the mucosa, the topical treatment of impaired mucosal membranes is discussed. A third section covers the wide spectrum of consumer products applied on mucosal surfaces. Finally, the safety of products for mucosal membranes is reviewed. Providing an excellent summary and review of the latest findings and topical applications, this book will be of great value to physicians and clinicians in dermatology or gynecology, pharmacists, scientists and toxicologists who are involved in the development of products for mucosal membranes.
  • v. 1, 1978.
    Shenker, I. Ronald.
    PrintStatus: Not Checked OutLane Catalog Record
  • v. 2-, 2005- Springer
    Bronner, Felix; Farach-Carson, Mary C.
  • 1980-
    Hill, Rolla Bennett; Terzian, James A.
    PrintStatus: Not Checked OutLane Catalog Record
  • v. 2, 1943.
    Pernkopf, Eduard.
    PrintStatus: Not Checked OutLane Catalog Record
    Bd. 1. Allgemeines, Brust und Brustgliedmasse -- Bd. 2. Bauch, Becken und Beckengliedmasse.
  • 2012 ScienceDirect
    2012 ClinicalKey
    Herndon, David N.
    A brief history of acute burn care management -- Teamwork for total burn care: Burn centers and multidisciplinary burn teams -- Epidemiological, demographic, and outcome characteristics of burn injury -- Prevention of burn injuries -- Burn management in disasters and humanitarian crises -- Care of outpatient burns -- Pre-hospital management, transportation and emergency care -- Pathophysiology of burn shock and burn edema -- Fluid resuscitation and early management -- Evaluation of the burn wound: Management decisions -- Enzymatic debridement of burn wounds -- Treatment of infection in burns -- Operative wound management -- Anesthesia for burned patients -- The skin bank -- Alternative wound coverings -- The role of alternative wound substitutes in major burn wounds and burn scar resurfacing -- The pathophysiology of inhalation injury -- Diagnosis and treatment of inhalation injury -- Respiratory care -- The systemic inflammatory response syndrome -- The immunological response and strategies for intervention -- Hematologic and hematopoietic response to burn injury -- Significance of the adrenal and sympathetic response to burn injury -- The hepatic response to thermal injury -- Effects of burn Injury on bone and mineral metabolism -- Vitamin and trace element homeostasis following severe burn injury -- Hypophosphatemia -- Nutritional support of the burned patient -- Modulation of the hypermetabolic response after burn injury -- Etiology and prevention of multisystem organ failure -- Renal failure in association with thermal injuries -- Critical care in the severely burned: Organ support and management of complications -- Burn nursing -- Special considerations of age: The pediatric burned patient -- Care of geriatric patients -- Surgical management of complications of burn injury -- Electrical injuries -- Electrical injury: Reconstructive problems -- Cold-induced injury: Frostbite -- Chemical burns -- Radiation injuries and vesicant burns -- Exfoliative diseases of the integument and soft tissue necrotizing infections -- The burn problem: A pathologist's perspective -- Molecular and cellular basis of hypertrophic scarring -- Pathophysiology of the burn scar -- Comprehensive rehabilitation of the burn patient -- Musculoskeletal changes secondary to thermal burns -- Mitigation of burn-induced hypermetabolic and catabolic response during convalescence -- Reconstruction of burn deformities: An overview -- The use of skin grafts, skin flaps and tissue expansion in burn deformity reconstruction -- Microvascular technique of composite tissue transfer -- Reconstruction of the head and neck -- Correction of burn alopecia -- Reconstruction of the burned breast -- Management of contractural deformities involving the shoulder (axilla), elbow, hip and knee joints in burned patients -- Care of a burned hand and reconstruction of the deformities -- Management of burn injuries of the perineum -- Reconstruction of burn deformities of the lower extremity -- The ethical dimension of burn care -- Intentional burn injuries -- Functional sequelae and disability assessment -- Cost-containment and outcome measures -- Management of pain and other discomforts in burned patients -- Psychiatric disorders associated with burn injury -- Psychosocial recovery and reintegration of patients with burn injuries.
  • 2013 Springer
    Knahr, Karl.
    Part I: Ceramic-on-Ceramic Articulations -- Technology and Handling of Ceramic Implants -- Long-Term Stability of Ceramic Composite in Total Hip Arthroplasty -- Ceramic-Ceramic Bearing in Difficult Hips (Primary and Revision) -- Alumina-on-Alumina Bearings in Hip Arthroplasty: What Every Surgeon Should Know -- Part II: Metal-on-Metal Articulations -- Metal-on-Metal Resurfacing and the Cost to the Nation: A Conservative Estimate of the Unexpected Costs Required to Implement the New Metal-on-Metal Follow-Up Programme in the UK -- A Clinicopathological Study of Metal-on-Metal Hips Revised for Suspected Adverse Reactions to Metal Debris -- Metal-on-Metal Bearings and Surgical Techniques in Active Patients with Severe Hip Deformity -- The Incidence of Pseudotumour in Metal-on-Metal Hip Resurfacing and the Results of a Screening Tool for Patient Recall -- Part III: Polyethylene - Standard and New Improvements -- New Polys and Large Heads: Clinical Aspects -- The Influence of Head Material on Polyethylene Wear -- Basic Science and Longtime Results of Different Polyethylene Articulations -- Part IV: Large Diameter Heads -- Head Size and Metal-on-Metal Bearings -- Aseptic Loosening of Metal-on-Metal (MOM) Total Hip Arthroplasties (THA) with Large-Diameter Heads -- Large Head Articulations: Benefits and Drawbacks -- Can the Increased Loosening Rate of the Modular-Neck Hip Systems Be Attributed to Geometric Design Parameters? An Alternative Approach Using Finite Element Analysis -- Fracture of the Titanium Neck in a Modular Femoral Component -- Part V: Clinical Aspects -- Wear of Hard-on-Hard Bearings in the Hip: The Influence of Loss of Conformity Under Edge Loading -- Considerations for the Use of Bearing Partners in Total Hip Arthroplasty -- Total Hip Arthroplasty Using a Short, Metaphyseal-Fitting Anatomic Cementless Femoral Component in Patients with Femoral Head Osteonecrosis Who Are Less than 30 Years Old -- Survival of Monoblock Acetabular Cups Versus an Uncemented Modular Cup Design: A Population-Based Study from the Swedish Hip Arthroplasty Register.
  • 2012 Springer
    Knahr, Karl.
    Introduction: Tribology of hip prostheses -- wear performance and reliability -- effect of materials and head size -- How to treat failures related to articulation. Polyethylene articulations: Oxidation prevention with vitamin E in a HXLPE isoelastic monoblock pressfit cup -- Preliminary results -- In-Vitro Wear Testing of Conventional vs. Sequentially Cross-Linked Polyethylene Liners in Combination with Different Ceramic Femoral Heads -- Characterization of Vitamin E-blended UHMWPE for higher in vivo performance in orthopaedic arthroplasty -- Long-term reduction of wear and osteolysis with crosslinked PE? 13-years follow-up of a prospectively randomized comparison with conventional PE. Metal articulations: Metal-on-metal bearings in hip surgery: The London Implant Retrieval Centre Experience -- Total Hip Arthroplasty with a large diameter metal-on-metal cup (Durom) and a standard stem -- Short term results -- Polyethylene wear in metal-backed cups -- A retrospective analysis of 200 uncemented metal-backed cups. Immunological adverse reaction associated with low carbide content metal-on-metal bearings in a contemporary cementless total hip arthroplasty. Ceramic articulations: Fracture and squeaking in ceramic-on-ceramic bearings -- is it really a concern?- Long term stability of ceramic composite in total hip arthroplasty -- Ceramic-on-ceramic bearings in hip arthroplasty: a clinical review. Miscellaneous: Study of a titanium dual mobility socket with a mean follow-up of 18 years -- ECIMATM for low wear, good mechanical properties and oxidation resistance of hip bearings.
  • 2015 Springer
    Oussedik, Sam; Rodríguez-Merchán, E. C.
    This book offers a comprehensive guide to total knee arthroplasty (TKA) that will assist in achieving excellent outcomes based on a sound understanding and technique. After an introductory section on the native knee that covers the anatomy, physiology, biomechanics, and patterns of disease, all aspects of primary knee arthroplasty are discussed in detail. Individual chapters are devoted to topics such as acute pain management, the role of technological aids, prosthetic kinematics, alignment targets, unicompartmental arthroplasty, patellar resurfacing, outcome measures, and cost-effectiveness. An extensive section explains the causes and management of potential complications, including aseptic failure, infections, and periprosthetic fracture. The surgical techniques appropriate for revision knee arthroplasty are described separately, and guidelines on how to deal with bone loss, instability, and extensor mechanism failure are provided. The authors are all respected experts from the United Kingdom, United States, Australia and Europe.
  • 2015 Springer
    Karachalios, Theofilos.
    1. A brief history of total knee arthroplasty -- 2. Kinematics of the natural and replaced knee -- 3. Long term survival of total knee arthroplasty. Lessons learned from the clinical outcome of old designs -- 4. Long term survival of total knee arthroplasty. Lessons learned from the clinical outcome of old designs. Second generation of implants and the total condylar TKA -- 5. Total knee arthroplasty. Evaluating outcomes -- 6. The long term outcome of total knee arthroplasty. The effect of age and diagnosis -- 7. Long term outcome of primary total knee arthroplasty. The effect of body weight and level of activity -- 8. Long term clinical outcome of total knee arthroplasty. The effect of the severity of deformity -- 9. Long term clinical outcome of total knee arthroplasty. The effect of surgeon training and experience -- 10. Long term clinical outcome of total knee arthroplasty. The effect of limp alignment, implant placement and stability as controlled by surgical technique -- 11. Long term results of total knee arthroplasty. The effect of surgical approach -- 12. Long term clinical outcome of total knee arthroplasty. The effect of posterior stabilized designs -- 13. Long term clinical outcome of total knee arthroplasty. The effect posterior cruciate retaining design -- 14. Rationale and long term outcome to rotating platform total knee replacement -- 15. Mid to long term clinical outcome of medial pivot designs -- 16. Long term clinical outcome of total knee arthroplasty. The effect of implant fixation (cementless) -- 17. Long term clinical outcome of total knee arthroplasty: the effect of polyethylene -- 18. Long term clinical outcome of total knee arthroplasty. Condylar constrained prostheses -- 19. Long term clinical outcome of total knee arthroplasty rotating hinge designs -- 20. Clinical outcome of total knee megaprosthesis replacement for bone tumors -- 21. Long term clinical outcome of total knee arthroplasty. The effect of patella resurfacing -- 22. Infected total knee arthroplasty. Basic science, mangement, and outcome -- 23. Short and mid term outcome of total knee arthroplasty. The effect of rahabilitation -- 24. Mid and long term functional outcome of total knee arthroplasty -- 25. Long term outcome of total knee arthroplasty. The effect of navigation -- 26. Quality of life and patient satisfaction after total knee arthroplasty using contemporary designs -- Index.
  • 2014 ClinicalKey
    Scott, Richard D.
    Posterior cruciate ligament retention versus substitution -- Mobile versus fixed bearings in total knee arthroplasty -- Primary total knee arthroplasty surgical technique -- Total knee arthroplasty in severe varus deformity -- Total knee arthroplasty in severe valgus deformity -- Patellofemoral complications associated with total knee arthroplasty -- Stiffness before and after total knee arthroplasty -- Flexion contracture associated with total knee arthroplasty -- Total knee arthroplasty after osteotomy -- Total knee arthroplasty in rheumatoid arthritis -- Bone stock deficiency in total knee arthroplasty -- Bilateral simultaneous total knee arthroplasty -- Sepsis and total knee arthroplasty -- Staying out and getting out of trouble during total knee arthroplasty -- Repeat operation after total knee arthroplasty -- Unicompartmental knee arthroplasty -- Unicompartmental knee arthroplasty technique -- Frequently asked questions concerning total knee arthroplasty.
  • 2009 ClinicalKey
    Hanssen, Arlen D.; Scott, W. Norman.
    Unicompartmental Knee Arthroplasty -- Posterior Cruciate Ligament-Retaining Total Knee Arthroplasty -- Posterior-Stabilized Technique -- Methods of Rotational Alignment in Primary Total Knee Arthroplasty -- Valgus Total Knee Replacement -- Total Knee Replacement in the Varus Knee -- Tibial Component Alignment in Total Knee Arthroplasty: Intramedullary, Extramedullary, and Computer-Assisted Techniques -- Quadriceps-Sparing Total Knee Arthroplasty -- Minimally Invasive Total Knee Arthroplasty with Limited Medial Parapatellar Arthrotomy -- Minimally Invasive Subvastus Approach for Total Knee Arthroplasty -- Minimal Incision Total Knee Arthroplasty: the Mini-Midvastus Approach -- Monoblock Total Knee Arthroplasty -- Cementless Fixation -- Cemented Total Knee Arthroplasty -- Principles of Revision Total Knee Replacement -- Preoperative Planning for Revision Total Knee Replacement -- Surgical Exposures for Revision Total Knee Arthroplasty -- Soft Tissue Balancing in Revision Total Knee Arthroplasty -- Removing Well-Fixed Implants -- Revision of Failed Unicompartmental Knee Arthroplasty -- Cemented Stem Fixation in Revision Total Knee Arthroplasty -- Uncemented Stems in Revision Total Knee Arthroplasty -- PROSTALAC Articulating Spacer for Infected Total Knee Replacements -- Impaction Bone Grafting for Defects in Revision Total Knee Arthroplasty -- Treatment of Periprosthetic Femoral Fractures above a Total Knee Arthroplasty -- Knee Arthrodesis with an Intramedullary Nail After Failed Total Knee Arthroplasty -- Flexion and Extension Gap Balancing in Revision Total Knee Arthroplasty -- Extensor Mechanism Reconstruction in Total Knee Arthroplasty -- Metal Augments -- Metaphyseal Porous Metal Cones -- Structural Allografting -- Porous Tantalum for Patellar Reconstruction in Revision Total Knee Arthroplasty -- Cancellous Patellar Bone Grafting in Revision Total Knee Arthroplasty -- Hinged Total Knee Arthroplasty.
  • 2003 NLM
    Heiland, Jennifer R.; Klein, Lori; Panagis, James S.
    Assesses the current state of the science regarding primary and revision total knee replacements. References appear in 5 broad categories that parallel topics presented at the conference, with many of the topics further broken down. Citations may appear in only one category.
  • 2015 Springer
    Siquini, Walter.
    Preface -- 1 Position of the patient -- 2 Steps shared by Total and Subtotal Gastrectomy -- 3 Total Gastrectomy -- 4 Manual Subtotal Gastrectomy.- 5 Stapled Subtotal Gastrectomy -- 6 Proximal Gastrectomy -- 7 Total and Subtotal D2 Laparoscopic Gastrectomy.- 8 Lymphadenectomy -- 9 Special Cases.
  • 2008 Springer
    Lipton, Michael L.; Kanal, Emanuel.
    Part I. In the Beginning: Generating, Detecting, and Manipulating the MR (NMR) Signal -- Laying the Foundation: Nuclear Magnetism, Spin, and the NMR Phenomenon -- Rocking the Boat: Resonance, Excitation, and Relaxation -- Relaxation: What Happens Next? -- Image Contrast: T1, T2, T2*, and Proton Density -- Hardware, Especially Gradient Magnetic Fields -- Part II. User Friendly: Localizing and Optimizing the MRI Signal for Imaging -- Spatial Localization: Creating an Image -- Defining Image Size and Spatial Resolution -- Putting It All Together: An Introduction to Pulse Sequences -- Understanding, Assessing, and Maximizing Image Quality -- Artifacts: When Things Go Wrong, It's Not Necessarily All Bad -- Safety: First, Do No Harm -- Part III. To the Limit: Advanced MRI Applications -- Preparatory Modules: Saturation Techniques -- Readout Modules: Fast Imaging -- Volumetric Imaging: The Three-dimensional Fourier Transform -- Parallel Imaging: Acceleration with SENSE and SMASH -- Flow and Angiography: Artifacts and Imaging of Coherent Motion -- Diffusion: Detection of Microscopic Motion -- Understanding and Exploiting Magnetic Susceptibility -- Spectroscopy and Spectroscopic Imaging: In Vivo Chemical Assays by Exploiting the Chemical Shift.
  • 2012 Springer
    Biffi, Roberto; Di Carlo, Isidoro.
    Since their first application in 1982, Totally Implantable Venous Access Devices (TIVADs) have become increasingly important in the clinical practice, as more intensive chemotherapy and parenteral treatments have come into use. At this time, there is objective evidence that TIVADs are a safe, effective strategy for long-term venous access; they play a significant role throughout the management of the oncology patient, as they are needed in the initial phases for active treatments as well as in the last stages for palliative measures, making possible repeated administration of chemotherapeutic vesicant agents, nutrients, antibiotics, analgesics, and blood products. According to a number of prospective studies, use of TIVADs is associated with a significant complication rate (10% to 25% of all patients). Evidence-based data support that most complications are directly related to inappropriate technique of placement and/or nursing care, sometimes leading to TIVAD loss, significant morbidity, increased duration of hospitalization, and additional medical cost. A group of world-renowned experts - both in the clinical and research fields - contributed to this volume, whose aim is to provide clinicians, nurses and medical students with a multidisciplinary, full update on these devices, as long term central venous access can no be longer considered a routine matter, and serious complications can be maintained at a very low level only if strict adherence to a well-defined protocol of surgical technique and of catheter care is maintained.
  • 2012
    Schulze, Anke.
    Zur Entwicklung des nationalen Habitus in Deutschland -- Veränderungen des Verhaltens-, Gefühls- und Denkstandards von Ärzten -- Geschichte der Medizin anhand einiger ausgewählter Schwerpunkte -- Der unpolitische Arzt? -- Die satisfaktionsfähige Gesellschaft -- Militärmedizin im Ersten Weltkrieg -- Schubkraft von Kriegen -- Zur Geschichte der deutschen Psychiatrie -- Von der Entstehung der Eugenik als Wissenschaft zur Diskussion und Durchführung der Tötungen von Menschen -- Die Theorie Darwins und die Entwicklung sozial-darwinistischer Vorstellungen -- Auswirkungen der Darwinschen Theorie -- Vom Sozialdarwinismus zur Rassenhygiene -- Zur Entwicklung eugenischer Konzepte in Deutschland -- Ärzte helfen Hitler und der nationalsozialistischen Bewegung -- Die Freikorps : Wegbereiter Hitlers -- Vom heilenden zum tötenden Arzt : die Auflösung des Gewissens -- Die Ausschaltung jüdischer Ärzte -- Zwangssterilisationen -- Tötungen von Kindern -- Erwachsenentötungen -- Ärzte übernehmen direktes medizinisches Töten -- Selektion an der Rampe : Ärzte im Konzentrationslager -- Ärztliche Tätigkeiten in Konzentrationslagern -- Menschenversuche : Ärzte experimentieren am "Objekt Mensch -- Unterdruck- und Unterkühlungsversuche -- Versuche mit Fleckfieber-Impfstoff -- Hepatits Epidemica-Virus-Forschung -- Sulfonamid-, Knochentransplantations- und Phlegmonversuche -- Zwillingsforschung : das Kaiser Wilhelm-Institut für Anthropologie, menschliche Erblehre und Eugenik in Berlin Dahlem und das Konzentrationslager Auschwitz -- Der Prozess und die Urteile von Nürnberg -- Exkurs : nach 1945 -- Schlussbetrachtung -- Literaturverzeichnis.
  • 2013
    Koppelman, Andrew.
    Introduction -- The road to the mandate -- Appropriate constitutional limits -- Bad news for mail robbers -- What the court did -- Where it hurts.
  • 2006 Ovid
    Hollenbeck, Peter J.; Mink, Jonathan W.; Walkup, John T.
    Also available: Print – 2006
  • 2008 Springer
    Mayorga, R. V.; Perlovsky, Leonid I.
  • 2011
    Chang, Catherine Elizabeth; Glover, Gary H.; Nishimura, Dwight George; Wandell, Brian A.
    Functional magnetic resonance imaging (fMRI) based on blood-oxygen level dependent (BOLD) contrast is a powerful technique for non-invasive measurement of brain activity. Recent fMRI studies have revealed that the spontaneous BOLD fluctuations of the human brain organize into distributed, temporally-coherent networks ("resting-state networks"; RSNs). Examination of RSNs has yielded valuable insight into neural organization and development, and demonstrates potential as a biomarker for conditions such as Alzheimer's disease and depression. However, the accuracy by which the spatio-temporal properties of RSNs can be delineated using fMRI is compromised by the presence of physiological (cardiac and respiratory) noise and vascular hemodynamic variability. Further, our present understanding of how RSNs may interact and support cognitive function has been limited by the fact that the vast majority of studies to-date analyze RSNs in a manner that assumes temporal stationarity. Here, we describe efforts to correct for non-neural physiological influences on the BOLD signal, as well as investigations into the dynamic character of resting-state network connectivity. It is found that low-frequency variations in cardiac and respiratory processes account for significant noise across widespread gray matter regions, and that a constrained deconvolution approach may prove effective for modeling and reducing their effects. Application of the proposed noise-reduction procedure is observed to yield negative correlations between the spontaneous fluctuations of two major RSNs. The relationship between respiratory volume changes and the BOLD signal is further examined by simultaneously monitoring and comparing chest expansion data, end-tidal gas concentrations, and spontaneous BOLD fluctuations. The use of a breath-holding task is proposed for quantifying regional differences in BOLD signal timing that arise from local vasomotor response delays; such non-neural timing delays are found to impact inferences of resting-state connectivity and causality. Finally, a preliminary analysis of non-stationary connectivity between RSNs is performed using wavelet and sliding-window approaches, and it is observed that interactions between networks may reconfigure on time-scales of seconds to minutes.
  • 2011 NCBI Bookshelf
    "Motivated by the explosion of molecular data on humans-particularly data associated with individual patients-and the sense that there are large, as-yet-untapped opportunities to use this data to improve health outcomes, Toward precision medicine explores the feasibility and need for "a new taxonomy of human disease based on molecular biology" and develops a potential framework for creating one. The book says that a new data network that integrates emerging research on the molecular makeup of diseases with clinical data on individual patients could drive the development of a more accurate classification of diseases and ultimately enhance diagnosis and treatment. The "new taxonomy" that emerges would define diseases by their underlying molecular causes and other factors in addition to their traditional physical signs and symptoms. The book adds that the new data network could also improve biomedical research by enabling scientists to access patients' information during treatment while still protecting their rights. This would allow the marriage of molecular research and clinical data at the point of care, as opposed to research information continuing to reside primarily in academia. Toward precision medicine notes that moving toward individualized medicine requires that researchers and health care providers have access to very large sets of health- and disease-related data linked to individual patients. These data are also critical for developing the information commons, the knowledge network of disease, and ultimately the new taxonomy."--Publisher's description.
  • 2014 Springer
    Miettinen, Olli S.
    Scientific medicine in Miettinen's conception of it is very different from the two ideas about it that came to eminence in the 20th century. To him, medicine is scientific to the extent that it has a rational theoretical framework and a knowledge-base from medical science. He delineates the nature of that theoretical framework and of the research to develop the requisite knowledge for application in such a framework. The knowledge ultimately needed is about diagnostic, etiognostic, and prognostic probabilities, and it necessarily is to be codified in the form of probability functions, embedded in practice-guiding expert systems.
  • 2009 Springer
    Koh, Howard K.
  • 2008
    Heffner, Garrett Collins.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Derzelle, Martine.
    A rigorous and groundbreaking study. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. Martine Derzelle is the first researcher to approach hypochondria as a relational pathology. The author tackles a subject that has puzzled care professionals for decades: hypochondria. Martine Derzelle confronts all specialists (psychotherapists, psychiatrists, doctors, psychosomaticians) with the paradox of this pathology and the theoretical void on which the approach to those patients who express a suffering of various kinds has stood for more than a century. In the first part, the author highlights the lack of theoretical elaboration on hypochondria in the existent literature; in the second part, on the basis of clinical examples, she analyzes the nature of the disease, and then offers a completely innovative theoretical elaboration. Finally, in the third part, she proposes a new and specific approach to treating this pathology at both the theoretical and clinical levels within the framework of psychoanalysis and implementing key concepts from relational psychosomatics.
  • 2013 Springer
    Coward, L. Andrew.
    The book explains how to understand cognition in terms of brain anatomy, physiology and chemistry, using an approach adapted from techniques for understanding complex electronic systems. These techniques create hierarchies of information process based descriptions on different levels of detail, where higher levels contain less information and can therefore describe complete cognitive phenomena, but are more approximate. The nature of the approximations are well understood, and more approximate higher level descriptions can therefore be mapped to more precise detailed descriptions of any part of a phenomenon as required. Cognitive phenomena, the anatomy and connectivity of major brain structures, neuron physiology, and cellular chemistry are reviewed. Various cognitive tasks are described in terms of information processes performed by different major anatomical structures. These higher level descriptions are selectively mapped to more detailed physiological and chemical levels.--[Source inconnue].
  • 2010 Springer
    Glatzeder, Britt M.; Goel, Vinod; Müller, Albrecht A. C. von.
    Part I. Perspectives on Thinking -- Problem Solving / Michael Öllinger and Vinod Goel -- Heuristic Bias, Conflict, and Rationality in Decision-Making / Wim De Neys -- Analogical Processes in Human Thinking and Learning / Dedre Gentner and Julie Colhoun -- A Gestalt Perspective on the Psychology of Thinking / Michael Wertheimer -- Thought and Reality: A Philosophical Conjecture About Some Fundamental Features of Human Thinking / Albrecht von Müller -- Part II. Components of Thinking -- Categorization and Object Shape / Markus Graf -- Comparison / Robert L. Goldstone, Sam Day, and Ji Y. Son -- Causal Thinking / Michael R. Waldmann -- Conditionals: Their Meaning and Their Use in Reasoning / Klaus Oberauer -- Thinking and Memory / Matthias Brand and Hans J. Markowitsch -- Perception and the Brain / Nikos Logothetis -- Part III. Onto- and Phylogenetic Considerations -- A Developmental Perspective on Modularity / Annette Karmiloff-Smith -- Theory of Mind / Beate Sodian and Susanne Kristen -- The Development of Metacognitive Competences / Wolfgang Schneider -- Understanding Apes to Understand Humans: The Case of Object-Object Relations / Josep Call -- Part IV. Language, Emotion, Culture -- Socializing Cognition / Anne Böckler, Günther Knoblich, and Natalie Sebanz -- Thinking and Language: A View from Cognitive Semio-Linguistics / Per Aage Brandt -- Thinking and Emotion: Affective Modulation of Cognitive Processing Modes / Annette Bolte and Thomas Goschke -- Cultural Differences in Thinking Styles / Shihui Han -- Part V. Modeling and Neurobiological Aspects -- Natural Selection in the Brain / Chrisantha Fernando and Eörs Szathmáry -- Value and Self-Referential Control: Necessary Ingredients for the Autonomous Development of Flexible Intelligence / Olaf Sporns and Edgar Körner -- Cortical Connectivity: The Infrastructure of Thoughts / Giorgio M. Innocenti -- Models as Tools to Aid Thinking / Helge Ritter.
  • 2012
    Nuyujukian, Paul Herag; Boahen, Kwabena; Henderson, Jaime; Shenoy, Krishna V.
    Neural prostheses translate signals from the brain into useful control signals, manipulating end-effectors such as computer cursors or robotic arms. Their aim is to offer greater interaction with the world for patients suffering from limb dysfunction due to spinal cord injury, neurodegenerative disease, and other conditions leading to limb paralysis. Prior intracortical electrode neural prosthesis studies have demonstrated compelling proof-of-concept systems, but barriers to successful clinical translation still remain, such as performance and robustness. Measures of performance include the speed, accuracy, and bitrate of the system. Robustness refers to the sustained performance of the system within a day and across days. The work presented here demonstrates algorithms and advances for neural prostheses that increase both performance and robustness. The recalibrated feedback intention trained Kalman filter (ReFIT-KF) increased performance by at least twofold compared to previously reported decoders, approaching the speed of natural arm movements. It achieved bitrates of up to 4.5 bits per second (bps) and communication rates of up to 10 words per minute (wpm) when used on a typing task. These results were reliable and repeatable for hours at a time across 4 array-years between two subjects. Utilizing neural spike threshold crossings as a signal source, the ReFIT-KF algorithm also demonstrated sustainable performance without any changes to decoder weights for one year with a degradation rate of 0.05 bps per month. Performance further increased when the ReFIT-KF was combined with an HMM state decoder for the detection of clicks, eliminating the need for hold periods. This combined ReFIT-KF and HMM decoder achieved bitrates of up to 6.5 bps and 15 wpm. Taken together, these findings may help advance neural prostheses closer to clinical viability.
  • 2010
    Gilja, Vikash; Meng, Teresa H.; Ng, Andrew Y.; Shenoy, Krishna V.
    By restoring the ability to move and communicate with the world, brain machine interfaces (BMIs) offer the potential to improve quality of life for people suffering from spinal cord injury, stroke, or neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS). BMIs attempt to translate measured neural signals into the user's intentions and, subsequently, control a computer or actuator. Recently, compelling examples of intra-cortical BMIs have been demonstrated in tetraplegic patients. Although these studies provide a powerful proof-of-concept, clinical viability is impeded by limited performance and robustness over short (hours) and long (days) timescales. We address performance and robustness over short time periods by approaching BMIs as a systems level design problem. We identify key components of the system and design a novel BMI from a feedback control perspective. In this perspective, the brain is the controller of a new plant, defined by the BMI, and the actions of this BMI are witnessed by the user. This simple perspective leads to design advances that result in significant qualitative and quantitative performance improvements. Through online closed loop experiments, we show that this BMI is capable of producing continuous endpoint movements that approach native limb performance and can operate continuously for hours. We also demonstrate how this system can be operated across days by a bootstrap procedure with the potential to eliminate an explicit recalibration step. To examine the use of BMIs over longer timescales, we develop new electrophysiology tools that allow for continuous multi-day neural recording. Through application of this technology, we measure the signal acquisition stability (and instability) of the electrode array technology used in current BMI clinical trials. We also demonstrate how these systems can be used to study BMI decoding over longer time periods. In this demonstration, we present a simple methodology for switching BMI systems on and off at appropriate times. The algorithms and methods demonstrated can be run with existing low power application specific integrated circuits (ASICs), with a defined path towards the development of a fully implantable neural interface system. We believe that these advances are a step towards clinical viability and, with careful user interface design, neural prosthetic systems can be translated into real world solutions.
  • 2010 Springer
    Belzen, J. A. van.
    This book takes a bold stand: all psychology should be culturally sensitive psychology, especially when studying religious phenomena. It explains that culture is not simply to be conceived of as a variable that possibly influences behavior. Rather, it stresses that cultural patterns of acting, thinking and experiencing are created, adopted and promulgated by a number of individuals jointly. As human subjectivity is different in different cultures, cultural psychology is not interested in comparatively investigating how experiences and behavior, attitudes and social relationships present themselves within different cultural conditions. By consequence, cultural psychology does not start from Western psychological constructs, testing for their presence in other cultures, but from human acts and activities in specific cultures, analyzing them in a hermeneutical way. Like cultural psychology, psychology of religion currently enjoys more and more interest and rapid growth. But the two fields have remained rather unconnected in the recent past. Psychological research on religion has been pursued from a number of perspectives, among which a cultural psychological one has not yet become prominent. As religions, however conceptualized, are cultural entities of major importance, cultural psychology seems a natural ally to research on religion. Containing a number of studies, both theoretical and empirical, this volume takes a step towards a rapprochement of cultural psychology and psychology of religion.
  • 2011
    Petrovskaya, Anna V.; Cutkosky, Mark R.; Khatib, Oussama; Pratt, Vaughan R.
    Reliable perception is required in order for robots to operate safely in unpredictable and complex human environments. However, reliability of perceptual inference algorithms has been poorly studied so far. These algorithms capture uncertain knowledge about the world in the form of probabilistic belief distributions. A number of Monte Carlo and deterministic approaches have been developed, but their efficiency depends on the degree of smoothness of the beliefs. In the real world, the smoothness assumption often fails, leading to unreliable perceptual inference results. Motivated by concrete robotics problems, we propose two novel perceptual inference algorithms that explicitly consider local non-smoothness of beliefs and adapt to it. Both of these algorithms fall into the category of iterative divide-and-conquer methods and hence scale logarithmically with desired accuracy. The first algorithm is termed Scaling Series. It is an iterative Monte Carlo technique coupled with annealing. Local non-smoothness is accounted for by sampling strategy and by annealing schedule. The second algorithm is termed GRAB, which stands for Guaranteed Recursive Adaptive Bounding. GRAB is an iterative adaptive grid algorithm, which relies on bounds. In this case, local non-smoothness is captured in terms of local bounds and grid resolution. Scaling Series works well for beliefs with sharp transitions, but without many discontinuities. GRAB is most appropriate for beliefs with many discontinuities. Both of these algorithms far outperform the prior art in terms of reliability, efficiency, and accuracy. GRAB is also able to guarantee that a quality approximation of the belief is produced. The proposed algorithms are evaluated on a diverse set of real robotics problems: tactile perception, autonomous driving, and mobile manipulation. In tactile perception, we localize objects in 3D starting with very high initial uncertainty and estimating all 6 degrees of freedom. The localization is performed based on tactile sensory data. Using Scaling Series, we obtain highly accurate and reliable results in under 1 second. Improved tactile object localization contributes to manufacturing applications, where tactile perception is widely used for workpiece localization. It also enables robotic applications in situations where vision can be obstructed, such as rescue robotics and underwater robotics. In autonomous driving, we detect and track vehicles in the vicinity of the robot based on 2D and 3D laser range finders. In addition to estimating position and velocity of vehicles, we also model and estimate their geometric shape. The geometric model leads to highly accurate estimates of pose and velocity for each vehicle. It also greatly simplifies association of data, which are often split up into separate clusters due to occlusion. The proposed Scaling Series algorithm greatly improves reliability and ensures that the problem is solved within tight real time constraints of autonomous driving. In mobile manipulation, we achieve highly accurate robot localization based on commonly used 2D laser range finders using the GRAB algorithm. We show that the high accuracy allows robots to navigate in tight spaces and manipulate objects without having to sense them directly. We demonstrate our approach on the example of simultaneous building navigation, door handle manipulation, and door opening. We also propose hybrid environment models, which combine high resolution polygons for objects of interest with low resolution occupancy grid representations for the rest of the environment. High accuracy indoor localization contributes directly to home/office mobile robotics as well as to future robotics applications in construction, inspection, and maintenance of buildings. Based on the success of the proposed perceptual inference algorithms in the concrete robotics problems, it is our hope that this thesis will serve as a starting point for further development of highly reliable perceptual inference methods.
  • 2008
    Dodet, Betty.
  • 2007
    Brown, Phil.
    Foreword / Lois Gibbs -- Preface : Toxic exposures and the challenge of environmental health -- Acknowledgments -- List of abbreviations -- 1. Citizen-science alliances and health social movements : contested illnesses and challenges to the dominant epidemiological paradigm -- 2. Breast cancer : a powerful movement and a struggle for science -- 3. Asthma, environmental factors, and environmental justice -- 4. Gulf War-related illnesses and the hunt for causation : the "stress of war" versus the "dirty battlefield" -- 5. Similarities and differences among asthma, breast cancer, and Gulf War illnesses -- 6. The new precautionary approach : a public paradigm in progress -- 7. Implications of the contested illnesses perspective -- 8. Conclusion : the growing environmental health movement -- Notes -- Bibliography -- Index.
  • 2015 Springer
    Fuentes, José M.
    Comprehensive overview of different aspects of autophagy as it relates to neurodegenerative diseases. The pathogenesis of the main neurodegenerative disorders includes either the accumulation of altered or misfolded proteins or exposure to several toxics. Autophagy constitute one of the two principal cellular pathways implicate in the clearance of these material and can serve as a neuroprotective mechanism. Topics include: the role of autophagy in the brain, the role of autophagy in the principal neurodegenerative disorders, and the mechanism by which different molecules cause neurotoxicity and the role autophagy plays.
  • 2013 CRCnetBASE
    Sahota, Pritam S.
    Overview of drug development / James A. Popp and Jeffery A. Engelhardt -- Nonclinical safety evaluation of drugs / Thomas M. Monticello and Jeanine L. Bussiere -- Toxicokinetics and drug metabolism : relating toxicity to compound exposure and disposition / David D. Christ -- Introduction to toxicologic pathology / Judit E. Markovits ... [et al.] -- Routine and special techniques in toxicologic pathology / Daniel J. Patrick, Peter C. Mann -- Principles of clinical pathology / Robert L. Hall -- Toxicogenomics in toxicologic pathology / Mark J. Hoenerhoff and David E. Malarkey -- Spontaneous lesions in control animals used in toxicity studies / Robert C. Johnson, Robert H. Spaet, Daniel L. Potenta -- Gastrointestinal tract / Judit E. Markovits -- Liver, gall bladder, and exocrine pancreas / Russell C. Cattley, James A. Popp, Steven L. Vonderfecht -- Respiratory system / David J. Lewis and Tom P. McKevitt -- Urinary system / Kendall S. Frazier and John Curtis Seely -- Hematopoietic system / Kristin Henson, Glenn Elliott, Gregory S. Travlos -- The lymphoid system / Patrick J. Haley -- Bone, muscle, and tooth / John L. Vahle ... [et al.] -- The cardiovascular system / Calvert Louden, David Brott -- Endocrine glands / Sundeep Chandra, Mark Hoenerhoff, Richard Peterson -- Reproductive system and mammary gland / Justin D. Vidal ... [et al.] -- Skin / Zbigniew Wojcinski ... [et al.] -- Nervous system / Mark T. Butt, Robert Sills, Alys Bradley -- Special senses : eye and ear / James A. Render, Kenneth A. Schafer, Richard A. Altschuler.
  • 2007 ATSDR
    Also available: Print – 2007
  • 2005 ATSDR
    Dorsey, Alfred.
    Also available: Print – 2005
  • 2004 ATSDR
    Also available: Print – 2004
  • 2004 ATSDR
    Also available: Print – 2004
  • 2007 ATSDR
    Also available: Print – 2007
  • 2007 ATSDR
    Also available: Print – 2007
  • 2007 ATSDR
    Also available: Print – 2007
  • 2005 ATSDR
    Risher, J.
    Also available: Print – 2005
  • 2005 ATSDR
    Faroon, Obaid.
    Also available: Print – 2005
  • 2004 ATSDR
    Also available: Print – 2004
  • 2004 ATSDR
    Also available: Print – 2004
  • 2006 ATSDR
    Also available: Print – 2006
  • 2006 ATSDR
    Williams, Malcolm.
    Also available: Print – 2006
  • 2006
    Wilbur, Sharon B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010 ATSDR
  • 2007 ATSDR
    Also available: Print – 2007
  • 2006 ATSDR
    Also available: Print – 2006
  • 2007 ATSDR
    Also available: Print – 2007
  • 2005 ATSDR
    El-Masri, Hisham.
    Also available: Print – 2005
  • 2005 ATSDR
    Fay, Mike.
    Also available: Print – 2005
  • 2008 ATSDR
    Also available: Print – 2008
  • 2005 ATSDR
    Harper, Carolyn.
    Also available: Print – 2005
  • 2006 ATSDR
    Also available: Print – 2006
  • 2005 ATSDR
    Keith, Sam.
    Also available: Print – 2005
  • 2006 ATSDR
    Todd, G. Daniel.
    Also available: Print – 2006
  • 2007 ATSDR
    Also available: Print – 2007
  • 2005 ATSDR
    Roney, Nickolette.
    Also available: Print – 2005
  • 2008 CRCnetBASE
    Nielsen, Elsa; Larsen, John Christian; Ostergaard, Grete.
    International and federal bodies involved in risk assessment of chemical substances -- Data for hazard assessment -- Hazard assessment -- Standard setting : threshold effects -- Standard setting : non-threshold effects (carcinogenicity) -- Exposure assessment -- Risk characterization -- Regulatory standards set by various bodies -- Combined actions of chemicals in mixture.
  • v. <1>, <1978>
    Sunshine, Irving.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 CRCnetBASE
    Castranova, Vincent; Young, Shih-Houng.
  • 2012 Knovel
    Donaldson, Kenneth.
    "The widespread and increasing use of carbon nanotubes in scientific and engineering research and their incorporation into manufactured goods has urged an assessment of the risks and hazards associated with exposure to them. The field of nanotoxicology studies the toxicology of nanoparticles such as carbon nanotubes and has become a major growth area aimed towards risk assessment of nanoparticles. Compiled by a team of leading experts at the forefront of research, this is the first book dedicated to the toxicology of carbon nanotubes. It provides state-of-the-science information on how and why they are so potentially dangerous if breathed in, including their similarities to asbestos. The book examines various aspects of carbon nanotubes, from their manufacture and aerodynamic behaviour to their effects at molecular level in the lungs. It is invaluable to the many groups involved with research in this area, as well as to regulators and risk assessors"-- Provided by publisher.
  • 2007 CRCnetBASE
    Awasthi, Yogesh C.
  • 2006 ScienceDirect
    Gupta, Ramesh C.
  • 1974-
    Hayes, Wayland J.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 CRCnetBASE
    Gad, Shayne C.
    Introduction: the gastrointestinal (GI) tract as a barrier and as an absorptive and metabolic organ / Shayne C. Gad -- Methods for the analysis of gastrointestinal function / Robin C. Guy -- Safety pharmacology and the GI tract / Henry I. Jacoby -- Gastronintestinal tract development and its importance in toxicology / Joseph V. Rodricks, Allison A. Yates, and Claire L. Kruger -- The GI tract as major route of pharmaceutical administration / Robert W. Kapp, Jr. -- Gastrointestinal function and toxicology in canines / Charles Spainhour -- Absorption of macromolecules by mammalian intestinal epithelium / Shayne C. Gad -- Peyer's patch epithelium: an imperfect barrier / Gary R. Burleson and Florence G. Burleson -- Alteration of intestinal function by xenobiotic exposure: animal models / Shayne C. Gad -- Intestinal absorption and metabolism of xenobiotics in laboratory animals / William J. Brock -- Normal and abnormal intestinal absorption by humans / David W. Hobson and Valerie L. Hobson -- Intestinal absorption and metabolism of xenobiotics in humans / William J. Brock and David W. Hobson.
  • 2005 CRCnetBASE
    Lash, Lawrence H.; Tarloff, Joan B.
  • 2006 CRCnetBASE
    Gardner, Donald E.
  • 2005 CRCnetBASE
    Pour, P. M.
  • 2010 CRCnetBASE
    Monteiro-Riviere, Nancy A.
    Pt. 1. Skin morphology and barrier properties -- pt. 2. Altered barriers -- pt. 3. Methods of delivery -- pt. 4. Skin toxicity.
  • v.1-2=, 2014 CRCnetBASE
    v.2 (2014) CRCnetBASE
    Rossini, Gian Paolo.
    Structured account of the existing knowledge of toxic algae, the chemistry of the toxins they produce, the effects these substances exert in humans and wildlife, as well as the strategies envisaged to protect public health and the environment. Covers recent advances in the understanding of the biology of toxin producers and the factors involved in the appearance and dynamics of harmful algae blooms, the factors affecting toxin production, the synthesis of toxins both in natural producers and by chemical means in a lab, and the toxin groups posing continuing and novel. Studies effects toxic microalgae and their poisonous products exert on living systems and how they may affect human activities.
  • 2010 Springer
    Kini, R. Manjunatha.
    "Circulation of blood is vital for the survival of vertebrates, including man. Mainly, it plays an important role in carrying food nutrients and oxygen to every tissue and organ and in removing all waste products and carbon dioxide. Any imbalance in the hemostatic and cardiovascular systems can lead to death and severe debility. A number of animals have developed mechanisms to target these systems and exploit the vulnerability. In some species (for example, snakes), such mechanisms are used to immobilize and kill the victim/prey, whereas in others (for example, insects, such as leaches, mosquitoes and ticks), they are used to provide a continuous supply of blood. These mechanisms include, but are not limited to, procoagulant and anticoagulant actions that affect the coagulation cascade and platelet aggregation, as well as altering vasodilatory responses. In all these various animals, these mechanisms have evolved to perfection over millions of years to support their survival. In last 3-4 decades, due to the efforts of scientists from various backgrounds including biology, protein chemistry, molecular biology, pharmacology, hematology, and structural biology, significant progress in understanding the structure-function relationships, as well as the mechanism of action have been made in a number of exogenous factors that affect blood coagulation, platelet aggregation and vasodilation from various animals. These exogenous factors have contributed significantly to the development of research tools as well as providing new therapeutic agents."
  • 2005 CRCnetBASE
    Dabrowski, Waldemar M.; Sikorski, Zdzisław E.
  • 2014 ScienceDirect
    Kim, Kami; Weiss, Louis M.
    This book reflects the significant advances in the field in the last 5 years, including new information on the genomics, epigenomics and proteomics of T. gondii as well as a new understanding of the population biology and genetic diversity of this organism.
  • 2010
    Ong, Yi-Ching; Bogyo, Matthew; Boothroyd, John C.; Mochly-Rosen, Daria; Nolan, Garry P.
    Toxoplasma gondii is an obligate, intracellular parasite of the Apicomplexan phylum that is able to infect nearly all warm-blooded vertebrates. This capability for survival in a variety of host niches is reflected in the diversification of Toxoplasma strains. Strains differ dramatically in their interaction with hosts, and a fruitful approach towards understanding the molecular underpinnings of disease has been to identify and characterize drivers of strain-specific differences in host response. Chapter 1 provides a general introduction to Toxoplasma gondii and its ability to modulate host immunity, with special attention given to what is known about the mechanisms behind strain-specific phenotypes and the role of one particular player, ROP16. Chapter 2 describes experiments demonstrating that Toxoplasma secretes a polymorphic tyrosine kinase, ROP16, that can directly phosphorylate host STAT6. These experiments made use of a targeted disruption of the ROP16 locus in Type I parasites to identify ROP16-dependent signaling pathways, and used biochemical approaches to dissect the mechanism by which ROP16 is able to induce rapid STAT6 activation. Chapter 3 describes work demonstrating that ROP16 activation of STAT6 directs murine macrophage polarization towards an alternatively activated (M2) phenotype. In Chapter 4, the avian host response to Toxoplasma is examined to determine whether strain-specific differences in host response might be inverted in non-mammalian hosts. We show that strain-specific transcriptional host response, as well as transcriptional host response modulated by ROP16, appears very similar in chickens as in mice and humans. This suggests that variance between mammalian and avian host species in general may not be the source of selective pressure for the success of these common strains, or of ROP16's variability. Chapter 5 concludes with a discussion of future directions for further characterization of ROP16's role in modulating host response. We show that ROP16 interacts with host chromatin and suggest that investigation of ROP16's function in the host nucleus might yield further molecular insights as to how Toxoplasma is able to co-opt host cells and influence the course of infection.
  • v. 1-5, 7-<9>, 1904/14-1937/46, 1954/57, 1960-65, <1965-1967>
    Vaccari de Venturini, Letizia.
    PrintStatus: Not Checked OutLane Catalog Record
    Tomo I. 1904-1914 -- Tomo II. 1915-1923 -- Tomo III. 1923-1930 -- Tomo IV. 1931-1936 -- Tomo V. 1937-1946 -- Tomo VII. 1954-1957 -- Tomo VIII. 1960-1965 -- Tomo IX. 1965-1967.
  • 2013
    Chen, Feng; Fuller, Margaret T.; Kim, Stuart K.; Krasnow, Mark; Lipsick, Joseph Steven.
    While there has been great progress in identifying stem and progenitor cells and the signals that control their proliferation and differentiation, how stem/progenitor cells exit their niche and how they form new tissue is not well understood. Unlike in the embryo, tissue formation in an adult animal faces new challenges such as longer distances to migrate and a complex milieu of differentiated tissue to migrate around and/or coordinate with. To restore function to a tissue, stem/progenitor cells must also integrate into healthy tissue and coordinate growth with decaying tissue. In this thesis, I examine how tracheal progenitor cells exit their niche to form tracheal tissue during Drosophila melanogaster metamorphosis. Tracheal progenitors exit the niche in two waves. During the first wave, progenitors migrate onto the basal surface of larval tracheal branches destined for destruction, and track along the decaying branches. Progenitor outgrowth requires the embryonic tracheal branch inducer, Breathless FGFR, and surprisingly, the Branchless FGF ligand is expressed in larval branches along which progenitors crawl. In this way, outgrowth is coordinated with tissue decay. Progenitors that remain within the niche during the first wave exit later. However, instead of moving onto the basal surface of larval branches, progenitors exiting the niche during this second wave move along the apical surface, displacing larval cells, and repopulating the tracheal branch. This latter process does not resemble branching morphogenesis in the embryo and does not require Bnl/Btl FGF signaling, demonstrating that progenitor outgrowth does not always require embryonic guidance cues.
  • 2008
    Johnson, Jonas T.; Myers, Eugene N.
    PrintStatus: Not Checked OutLane Catalog Record
    The history of tracheotomy and intubation / Steven M. Zeitels ... [et al.] -- Alternatives to tracheostomy / Andrew Herlich -- Technique and complications of tracheostomy in adults / Rohan R. Walvekar and Eugene N. Myers -- Technique and complications of tracheostomy in the pediatric age group / Robert F. Yellon -- Tracheostomy in the intensive care unit setting / K. Kost -- Selecting a tracheostomy tube: current options / Carl-Eric Lindholm -- Tracheostomy in burn patients / H. Slater -- Tracheostomy in patients with the obstructive sleep apnea syndrome / Jonas T. Johnson -- Nursing management of the patient with a tracheostomy / Marilyn Hudak and Margaret Hickey -- Long-term care of patients with a tracheostomy / David A. Nace and Andrea R. Fox -- Communication options for tracheostomy and ventilator-dependent patients / Marta S. Kazandjian and Karen J. Dikeman -- Management of swallowing disorders in the patient with a tracheostomy / R.L. Carrau and T. Wasserman-Wincko.
  • 2010
    Wennberg, John E.
    PrintStatus: Not Checked OutLane Catalog Record
    In health care, geography is destiny -- The Vermont experience -- Tonsillectomy and medical opinion -- Interpreting the pattern of surgical variation -- Understanding the market for preference-sensitive surgery -- Learning what works and what patients want -- The birth and near death of comparative effectiveness research -- Understanding supply-sensitive care -- Chronic illness and practice variation -- Is more better? -- Are America's "best hospitals" really the best? -- Ten top reasons why we need to reform the way we manage chronic illness -- Promoting organized care and reducing overuse -- Establishing shared decision making and informed patient choice -- Six ways to control costs, and accelerate health care reform -- The challenge of practice variations.
  • 2015 WHO
    This report is the first of its kind to measure health service coverage and financial protection to assess countries' progress towards universal health coverage. It shows that at least 400 million people do not have access to one or more essential health services and 6% of people in low- and middle-income countries are tipped into or pushed further into extreme poverty because of health spending.--Publisher description.
    Also available: Print – 2015
  • 2013 Cambridge
    Adams, James D.; Lien, Eric J.
    The traditional and scientific bases for traditional Chinese medicine : communication between traditional practitioners, physicians and scientists / James D. Adams, Jr. and Eric J. Lien -- Structure-activity relationship analysis of plant-derived compounds / Eric J. Lien, Linda L. Lien and James D. Adams -- Huang Di Nei Jing and the treatment of low back pain / Minchen Wang (Vince) -- Understanding ch'i : the life-force energy that determines vitality, health and wellbeing / Marcia R. Babcock -- When modern computational systems biology meets traditional Chinese medicine / Calvin Yu-Chian Chen -- Modern drug discovery from Chinese materia medica used in traditional Chinese medicine / Kuo-Hsiung Lee, Susan L. Morris-Natschke, Joshua Brattlie, Jingxi Xie and Eileen Belding -- PI3K-AKT signaling in cell growth and metabolism / Yang Li, Anketse Kassa and Bangyan L. Stiles -- The scientific evidence for using astragalus in human diseases / William C.S. Cho -- Traditional Chinese medicine : anti-inflammation for cancer prevention / Constance L. L. Saw, Chee L. Saw and Lita S.T. Chew -- Treatment of stroke with Dan Shen, Salvia miltiorrhiza / James David Adams, Jr. -- Drug discovery from traditional Chinese medicine for neurogenesis : implications for stroke and neurodegenerative diseases / Jiangang Shen and Xingmiao Chen -- Medicinal uses of seaweed in traditional Chinese medicine / Eri Oshima -- The preventive effect of traditional Chinese medicinal herbs on type 2 Diabetes mellitus / Zhijun Wang, Patrick Chan and Jeffrey Wang -- Translational approach to treating diabetes using acupuncture or electroacupuncture / Philip V. Peplow and G. David Baxter.
  • v. 1-, 2002- CRCnetBase
  • 2006 CRCnetBASE
    Soumyanath, Amala.
  • 2010 Springer
    Piccardi, Laura.
  • 2015 Springer
    Bergamaschi, Roberto; Fingerhut, Abe; Francis, Nader; Motson, Roger W.
    1. Learning environment and setting up a training unit in Minimal Access Surgery -- 2. Training curriculum in Minimal Access Surgery -- 3. Simulation and Training in Minimal Access Surgery -- 4. Training basic laparoscopic skills -- 5. Training for trainers in Endoscopy (colonoscopy) -- 6. Teaching advanced laparoscopic skills in colorectal surgery -- 7. Teaching advanced laparoscopic skills in surgery for morbid obesity -- 8. Teaching advanced laparoscopic skills in urological surgery -- 9. Training for new thechniques and robotic surgery in Minimal Access Surgery -- 10. Teletraining in Minimal Access Surgery -- 11. Assessment and Acreditation in Minimal Access Surgery -- 12. Training the trainer in laparoscopic surgery -- 13. The Human Factor in Minimal Access Surgical Training: How conscientious, well trained Surgeons make mistakes.
  • v. 1, 1889.
    Testut, L.
    PrintStatus: Not Checked OutLane Catalog Record
    t. 1. Ostéologie. Arthrologie. Myologie -- t. 2. Angéilogie. Système nerveux central -- t. 3. Système nerveux périphérique. Organes des sens -- t. 4. Appareil de la digestion. Appareil de la respiration et de la phonation. Appareil uro-génital. Embryologie.
  • v. 1-2. Google Books
    Fulltext (v.2) Google Books
    Tillaux, P.
    Also available: Print – v. 1-2., 1877-
  • Google Books
    Bouchard, Ch; Babinski, J.; Brissaud, Édouard; Charcot, J. M.
    Also available: Print – v. 10., 1899-
  • 2009 Springer
    Hébuterne, Xavier.
  • v. 1-3, 1911-15. Google Books
    Fulltext (v.2 1911) Google Books
    Fulltext (v.3 1912) Google Books
    Grasset, J.; Rimbaud, Louis.
    [t.] 1. Fonctions de réception, absorption, circulation, elaboration et élimination de la matière: trophobiologie (Deuxième édition revue et autmentée par le docteur Rimbaud. 1915. [8], 1,059 p. incl. XXXIII tables, 1 diagr.) -- 2. Fonctions de défense contre la maladie: antixénisme (1911. [6], 1,010 p. 2 fold. tables) -- 3. Fonctions de réception, élaboration et émission de l'énergie, neurobiologie: fonctions de reproduction: ontogénie et phylogénie, hérédité (1912. [6], 1,176 p. incl. 37 ill, XXXII tables).
  • v. 1, 4, 1964-.
    Binet, Jean Paul; Senèque, Jean.
    PrintStatus: Not Checked OutLane Catalog Record
  • Google Books
    Gérard, Ernest.
    Also available: Print – 1907.
  • Google Books
    Viault, François Guilbert; Jolyet, Félix.
    Also available: Print – 1894.
  • Google Books
    Espine, Jean Henri Adolphe d'; Picot, Constant.
    Also available: Print – 1899
  • Google Books
    Clerc, F.-F.
    Also available: Print – 1866-
  • Google Books
    Hillairet, Jean Baptiste S.; Gaucher, Ernest.
    Contents -- t. 1, fasc. 1. Anatomie et physiologie. Pathologie générale. fasc. 2. Dermatoses inflammatoires communes.
    Also available: Print – v. 1, 1881-85.
  • Google Books
    Leriche, René.
    t. 1. Fractures articulaires.
    Also available: Print – v. 1, 1917.
  • 2005 CRCnetBASE
    Kodali, Dharma R.; List, Gary R.
  • 1959
    Wallace, A. B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2005 Springer
    Gonzalez, Pedro Pablo; Merelli, Emanuela; Omicini, Andrea; Priami, Corrado.
  • 2006 Springer
    Cardelli, Luca; Emmott, Stephen; Priami, Corrado.
    Scientific Foundation for Global Computing / Robin Milner -- Interdisciplinary Innovation in International Initiatives / John C. Wooley -- A Grand Challenge for Converging Sciences / Ronan Sleep -- Applying Computer Science Research to Biodiversity Informatics: Some Experiences and Lessons / Andrew C. Jones -- e-Science and the VL-e Approach / L.O. (Bob) Hertzberger -- From Syntax to Semantics in Systems Biology Towards Automated Reasoning Tools / François Fages -- SYMBIONIC: A European Initiative on the Systems Biology of the Neuronal Cell / Ivan Arisi, Paola Roncaglia, Vittorio Rosato, Antonino Cattaneo -- A Biological Approach to Autonomic Communication Systems / Iacopo Carreras, Imrich Chlamtac, Francesco De Pellegrini, Csaba Kiraly, Daniele Miorandi, Hagen Woesner -- The Twilight of the Despotic Digital Civilization / Michel Riguidel -- A Compositional Approach to the Stochastic Dynamics of Gene Networks / Ralf Blossey, Luca Cardelli, Andrew Phillips -- A Weighted Profile Based Method for Protein-RNA Interacting Residue Prediction / Euna Jeong, Satoru Miyano.
  • 2006 Springer
    Hu, Xiaohua; Lin, Tsau Young; Pan, Yi; Priami, Corrado.
  • 2006 Springer
    Plotkin, G.; Priami, Corrado.
  • 2014 Springer
    Rami-Porta, Ramón; Zieliński, Marcin.
    Use of the transcervical approach in thoracic surgery has advanced significantly during the past 60 years, owing primarily to advances in technology. Nevertheless, the possibilities of this approach have never been compiled in a systematic way. This book aims to rectify the situation by describing, in a structured way, all the thoracic procedures that can be performed using the transcervical approach. Indications and contraindications, surgical techniques, complications, and results are all covered, based on the authors' experience and published reports. The contents encompass diverse surgical endoscopic procedures for diagnosis and staging, use of the transcervical approach for surgery to the thymus and mediastinum, lungs and bronchi, trachea, and esophagus, and miscellaneous items including the role of robotic surgery.
  • 2007 Karger
    Marcolin, M. A.; Padberg, F.
    Electroconvulsive therapy : update and new research / Eser, D. ... [et al.] -- Repetitive transcranial magnetic stimulation effects in vitro and in animal models / Keck, M.E. -- Neuroimaging of repetitive transcranial magnetic stimulation effects on the brain / George, M.S. ... [et al.] -- Efficacy and safety of prefrontal repetitive transcranial magnetic stimulation in affective disorders / Padberg, F. ... [et al.] -- Repetitive transcranial magnetic stimulation in augmentation of antidepressant drugs / Ortega Rumi, D.O. ... [et al.] -- Transcranial magnetic stimulation versus electroconvulsive therapy for the treatment of more severe major depression / Janicak, P.G. ... [et al.] -- Transcranial magnetic stimulation in schizophrenia / Odebrecht Rosa, M. ... [et al.] -- Repetitive transcranial magnetic stimulation in the treatment of obsessive-compulsive disorder and other anxiety disorders / Pridmore, S., Marcolin, M.A., Mansur, C.G. -- Repetitive transcranial magnetic stimulation in non-psychiatric disorders : pain, Parkinson's disease, stroke, tinnitus / Lefaucheur, J.-P, Khedr, E.M. -- Induction and modulation of neuroplasticity by transcranial direct current stimulation / Nitsche, M.A. ... [et al.] -- Magnetic seizure therapy for the treatment of depression / Lisanby, S.H., Peterchev, A. -- Theta burst stimulation / Huang, Y.-Z., Rothwell, J.C. -- Transcranial magnetic stimulation of deep brain regions : principles and methods / Roth, Y., Padberg, F., Zangen, A.
  • 2014 Springer Protocols
    Horvath, Jared Cooney; Pascual-Leone, Alvaro; Rotenberg, Alexander.
    Transcranial magnetic stimulation (TMS) device and foundational techniques / Alexander Rotenberg, Jared Cooney Horvath, and Alvaro Pascual-Leone -- Transcranial magnetic stimulation (TMS) safety considerations and recommendations / Umer Najib and Jared Cooney Horvath -- Neuronavigation for transcranial magnetic stimulation / Roch Comeau -- Reaching deep brain structures : the h-coils / Yiftach Roth and Abraham Zangen -- Single-pulse transcranial magnetic stimulation (TMS) protocols and outcome measures / Faranak Farzan -- Paired-pulse transcranial magnetic stimulation (TMS) protocols / Andrew Vahabzadeh-Hagh -- Repetitive transcranial magnetic stimulation (rTMS) protocols / Lindsay Oberman -- Offline and online "Virtual Lesion" protocols / Shirley Fecteau and Mark Eldaief -- State-dependent transcranial magnetic stimulation (TMS) protocols / Juha Silvanto and Zaira Cattaneo -- Combination of transcranial magnetic stimulation (TMS) with functional magnetic resonance imaging / Joan A. Camprodon and Mark A. Halko -- Electroencephalography during transcranial magnetic stimulation : current modus operandi / Marine Vernet and Gregor Thut -- Transcranial magnetic stimulation (TMS) clinical applications : therapeutics / Jared Cooney Horvath, Umer Najib, and Daniel Press -- Transcranial magnetic stimulation (TMS) clinical applications : diagnostics / Josep Valls-Sole -- Review of current clinical practice in the treatment of major depression / Mark A. Demitrack and David G. Brock -- Protocol for depression treatment utilizing h-coil deep brain stimulation / Yiftach Roth and Abraham Zangen -- Navigated transcranial magnetic stimulation : principles and protocol for mapping the motor cortex / Jari Karhu, Henri Hannula, Jarmo Laine, and Jarmo Ruohonen -- Speech mapping with transcranial magnetic stimulation / Phiroz E. Tarapore.
  • 2010 Springer Protocols
    Higgins, Paul J.
    A review of post-translational modifications and subcellular localization of Ets transcription factors : possible connection with cancer and involvement in the hypoxic response / Céline Charlot ... [et al.] -- Regulation of transcription factor function by targeted protein degradation : an overview focusing on p53, c-Myc, and c-Jun / Jukka Westermarck -- Review of molecular mechanisms involved in the activation of the Nrf2-ARE signaling pathway by chemopreventive agents / Aldo Giudice, Claudio Arra, and Maria C. Turco -- Subnuclear localization and intranuclear trafficking of transcription factors / Sayyed K. Zaidi ... [et al.] -- Analysis of ligand-dependent nuclear accumulation of Smads in TGF-[beta] signaling / Douglas A. Chapnick and Xuedong Liu -- Raf/MEK/MAPK signaling stimulates the nuclear translocation and transactivating activity of FOXM1 / Richard Y.M. Ma ... [et al.] -- Coupling of dephosphorylation and nuclear export of Smads in TGF-[beta] signaling / Fangyan Dai ... [et al.] -- Assessing sequence-specific DNA binding and transcriptional activity of STAT1 transcription factor / Thomas Meyer and Uwe Vinkemeier -- Analysis of nuclear export using photoactivatable GFP fusion proteins and interspecies heterokaryons / Kerry-Ann Nakrieko, Iordanka A. Ivanova, and Lina Dagnino -- Determination of nuclear localization signal sequences for Krüppel-like factor 8 / Tina S. Mehta, Farah Monzur, and Jihe Zhao -- Methods to measure nuclear export of [beta]-catenin using fixed and live cell assays / Manisha Sharma and Beric R. Henderson -- Imaging of transcription factor trafficking in living cells : lessons from corticosteroid receptor dynamics / Mayumi Nishi -- Hypoxia-inducible factors : post-translational crosstalk of signaling pathways / Elitsa Y. Dimova and Thomas Kietzmann -- The basic helix-loop-helix-leucine zipper gene Mitf : analysis of alternative promoter choice and splicing / Kapil Bharti ... [et al.] -- Phosphorylation control of nuclear receptors / Sébastien Lalevée, Christine Ferry, and Cécile Rochette-Egly -- Regulation of Krüpple-like [i.e. Krüppel-like] factor 5 by targeted protein degradation / Ceshi Chen -- Post-translational control of ETS transcription factors : detection of modified factors at target gene promoters / Li Li, Janice Saxton, and Peter E. Shaw -- Integration of protein kinases into transcription complexes : identifying components of immobilised in vitro pre-initiation complexes / Hong-Mei Zhang ... [et al.] -- Post-translational modification of p53 by ubiquitin / Chunhong Yan -- Phosphorylation-dependent regulation of SATB1, the higher-order chromatin organizer and global gene regulator / Dimple Notani ... [et al.] -- In vivo and in vitro tools to identify and study transcriptional regulation of USF-1 target genes / Marie-Dominique Galibert and Sébastien Corre -- Measuring the absolute abundance of the Smad transcription factors using quantitative immunoblotting / David C. Clarke and Xuedong Liu -- Flow cytometry analysis of transcription factors in T lymphocytes / Diana I. Albu, Danielle Califano, and Dorina Avram -- Identification of specific protein/E-box-containing DNA complexes : lessons from the ubiquitously expressed USF transcription factors of the b-HLH-LZ super family / Marie-Dominique Galibert and Yorann Baron.
  • 2013 Springer
    Abud, Helen; Hime, Gary.
    1. The Stem cell state / Gary R. Hime, Helen E. Abud -- 2. Induction of pluripotency / Corey Heffernan, Jun Liu, Huseyin Sumer -- pt. I. Model stem cell systems (A): invertebrate -- 3. Germline stem cells and their regulation in the nematode Caenorhabditis elegans / Aaron Kershner, Sarah L. Crittenden, Kyle Friend, Erika B. Sorensen, Douglas F. Porter -- 4.Transcriptional and post-transcriptional regulation of Drosophila germline stem cells and their differentiating progeny / Helen White-Cooper, Simona Caporilli -- 5. Stem cells in the Drosophila digestive system / Xiankun Zeng, Chhavi Chauhan, Steven X. Hou -- 6. Mechanisms of asymmetric progenitor divisions in the Drosophila central nervous system / Rita Sousa-Nunes, W. Gregory Somers -- pt. II. Model stem cell systems (B): vertebrate -- 7. Transcriptional/translational regulation of mammalian spermatogenic stem cells / Cathryn A. Hogarth -- 8. Transcriptional regulation and specification of neural stem cells / Kimberly J. Christie, Ben Emery, Mark Denham, Helena Bujalka, Holly S. Cate -- 9. Transcriptional control of epidermal stem cells / Briana Lee, Xing Dai -- 10. Regulation of intestinal stem cells by WNT and notch signalling / Katja Horvay, Helen E. Abud -- 11. Transcriptional regulation of haematopoietic stem cells / Adam C. Wilkinson, Berthold Göttgens -- 12. The Regulation of mesenchymal stem cell differentiation / David Cook, Paul Genever -- pt. III. Molecular families implicated in stem cell regulation -- 13. The Musashi family of RNA binding proteins: master regulators of multiple stem cell populations / Jessie M. Sutherland, Eileen A. McLaughlin, Gary R. Hime, Nicole A. Siddall -- 14. JAK-STAT signaling in stem cells / Rachel R. Stine, Erika L. Matunis -- 15. Myc in stem cell behaviour: insights from Drosophila / Leonie M. Quinn, Julie Secombe, Gary R. Hime -- 16. The Role of nuclear receptors in embryonic stem cells / Qin Wang, Austin J. Cooney -- 17. Epigenetic regulation of stem cells / Anton Wutz -- 18. Regulation of stem cell populations by microRNAs / Julie Mathieu, Hannele Ruohola-Baker -- 19. Myb and the regulation of stem cells in the intestine and brain: a tale of two niches / Jordane Malaterre, Lloyd Pereira, Robert G. Ramsay.
    Also available: Print – 2013
  • 2014 Springer
    Ellmeier, Wilfried; Taniuchi, Ichiro.
    Insights into the regulation of immune cell lineage differentiation and specification as well as into the control of lineage integrity, stability and plasticity are of fundamental importance to understanding innate and adaptive immune responses. In this volume, leading experts provide an up-to-date and comprehensive overview of recent advances in the transcriptional control mechanisms and transcription factor networks that regulate these processes in a variety of different immune cell lineages. The chapters cover the regulation of T versus B cell lineage choice, discuss early B cell development and pre-B cell leukemia prevention, address transcriptional control mechanisms during Th differentiation, in regulatory T cells and iNKT cells, detail genomic switches in helper cell fate choice and plasticity, and highlight the role of the BTB-zinc finger family of transcription factors in T cells. Moreover, the chapters discuss transcriptional networks in DCs, NK cells and in innate lymphoid cells. Together, the reviews illustrate key transcriptional control mechanisms that regulate the development and function of immune cells and demonstrate the impressive advances made over the last decade.
  • 2007
    Zahn, Jacob Michael.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012
    Cheung, Regina Kar Wuen; Engleman, Edgar G.; Nolan, Garry P.; Robinson, William H.; Steinman, Lawrence; Utz, Paul J.
    Plasmacytoid dendritic cells (pDCs) are a rare subset of immune cells characterized by their ability to secrete large amounts of interferon alpha (IFN[alpha]) in response to Toll Like Receptor (TLR) activation by viral and endogenous nucleic acids. In these studies, we developed novel techniques that fundamentally change how cellular biologists can detect and assess protein and gene expression in cells based on function instead of phenotype. These techniques, which allow for transcript profiling of cells sorted by intracellular cytokine staining, and high throughput single cell detection of RNA transcript, were used to examine the role of pDC subsets that differ by IFN[alpha] and TNF secretion. Transcript profiling of these subsets revealed that after activation, there are two subsets of pDCs; cytokine secreting pDCs which express inflammatory and tolerogenic mediators, and quiescent noncytokine secreting pDCs, which maintain mRNA profile of unstimulated pDCs. Single cell RNAflow demonstrated that gene expression in subsets of pDCs from FLT3L DC (FLDC) cultures, bone marrow, and spleen correlates with cytokine staining. From our transcript profile data, we generated a list of candidate surface markers for cytokine secreting pDCs, which we screened by CyTOF and present here. Finally, we performed functional analysis of CD4- and CD4+ pDC subsets, and demonstrated that CD4- pDCs contain more activateable pDCs which take up antigen and induce antigen specific T cell proliferation. Taken together, these studies suggest that upon TLR activation, concomitant expression of rate limiting signaling genes leads to stochastic pDC expression of IFN[alpha] and TNF, leaving a larger pool of non cytokine secreting pDCs that maintain their pDC phenotype and expression pattern, and which may be activated at a later time. These studies also demonstrate the utility of screening based on function (cytokine secretion) instead of phenotype, which in this case, allowed for more complete assessment of variation between cells of different function.
  • McKnight, Steven L.; Yamamoto, Keith R.
  • 2008 Springer
    Dudek, Serena M.
  • 2009
    Carey, Michael; Peterson, Craig L.; Smale, Stephen T.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 Springer Protocols
    Vancura, Ales.
    Genome-wide in vivo cross-linking of sequence-specific transcription factors / Xiao-Yong li and Mark D. Biggin -- Characterization of complex regulatory networks and identification of promoter regulatory elements in yeast : "in silico" And "wet-lab" approaches / Nuno P. Mira, Miguel C. Teixeira, and Isabel Sá-Correia -- Electrophoretic mobility shift assay analysis of NF[kappa]B transcriptional regulation by nuclear I[kappa]B[alpha] / Ashish Juvekar [and others] -- Probing endogenous RNA polymerase II pre-initiation complexes by electrophoretic mobility shift assay / Emmanuelle Wilhelm, Christopher Takacs, and Brendan Bell -- Elucidating protein : DNA complex by oligonucleotide DNA affinity purification / Teddy T.C. Yang and Chi-Wing Chow -- Chromatin immunoprecipitation assay as a tool for analyzing transcription factor activity / Padmaja Gade and Dhan V. Kalvakolanu -- Two-step cross-linking for analysis of protein-chromatin interactions / Bing Tian, Jun Yan, and Allan R. Brasier -- Chromatin immunoprecipitation analysis of NF[kappa]B transcriptional regulation by nuclear I[kappa]B[alpha] in human macrophages / Sitharam Ramaswami [and others] -- In vivo ChIP for the analysis of microdissected tissue samples / Chris Murgatroyd, Anke Hoffmann, and Dietmar Spengler -- Quantification of protein-DNA interactions by in vivo chromatin immunoprecipitation in yeast / Amparo Pascual-Ahuir and Markus Proft -- Mapping protein-DNA interactions using ChIP-sequencing / Charles E. Massie and Ian G. Mils -- ChIP and re-ChIP assays : investigating interactions between regulatory proteins, histone modifications, and the DNA sequences to which they bind / Agnieszka D. Truax and Susanna F. Greer -- Transcriptional regulation of genes via hypoxia-inducible factor / Olga Roche and Michael Ohh -- Exchange protein directly activated by cyclic AMP-1-regulated recruitment of CCAAT/enhancer-binding proteins to the suppressor of cytokine signaling-3 promoter / William A. Sands [and others] -- Computational analysis of promoter elements and chromatin features in yeast / John J. Wyrick -- Chromatin affinity purification / Ryoko Harada and Alain Nepveu -- Determination of histone acetylation status by chromatin immunoprecipitation / Luciano Galdieri, John Moon, and Ales Vancura -- Immunostaining of Drosophila polytene chromosomes to investigate recruitment of chromatin-binding proteins / Magdalena Murawska and Alexander Brehm -- Detection of transcriptional activators, co-activators, and chromatin remodeling by chromatin immunoprecipitation coupled with real-time PCR / Tamara Y. Erkina and Alexandre M. Erkine -- Chromatin endogenous cleavage and psoralen crosslinking assays to analyze rRNA gene chromatin in vivo / Joachim Griesenbeck [and others] -- UV-induced DNA damage and DNA repair in ribosomal genes chromatin / Julie Pelloux [and others] -- Analysis of SUC2 promoter structure by nucleosome scanning / Jennifer Chang and Ales Vancura -- Chromatin immunoprecipitation of mouse embryos / Anne K. Voss [and others] -- Chromatin immunoprecipitation in mouse hippocampal cells and tissues / Badi Sri Sailaja, Takumi Takizawa, and Eran Meshorer -- Approaches for studying nucleosome movement by ATP-dependent chromatin remodeling complexes / Swetansu K. Hota and Blaine Bartholomew -- Mapping protein-DNA and protein-protein interactions of ATP-dependent chromatin remodelers / Swetansu K. Hota [and others] -- Evaluation of histone-modifying enzymes in stem cell populations / Leanne Stalker and Christopher Wynder -- Purification of multiprotein histone acetyltransferase complexes / Yuan-Liang Wang, Francesco Faiola, and Ernest Martinez -- Reconstitution of active and stoichiometric multisubunit lysine acetyltransferase complexes in insect cells / Kezhi Yan [and others] -- Affinity purification of MLL3/MLL4 histone H3K4 methyltransferase complex / Young-Wook Cho, SunHwa Hong, and Kai Ge -- Methods for analyzing histone citrullination in chromatin structure and gene regulation / Pingxin Li, Jing Hu, and Yanming Wang -- Analysis of mRNA abundance and stability by ribonuclease protection assay / Cristina Romero-López [and others] -- Array-based nuclear run-on analysis / Jinshui Fan [and others] -- In vivo run-on assays to monitor nascent precursor RNA transcripts / Piergiorgio Percipalle and Emilie Louvet -- Genome wide full-length transcript analysis using 5' and 3' paired-end-tag next generation sequencing (RNA-PET) / Xiaoan Ruan and Yijun Ruan -- Analysis of co-transcriptional RNA processing by RNA- ChIP assay / Danielle Bittencourt and Didier Auboeuf -- Quantitative analysis of transcription elongation by RNA polymerase I in vitro / David Alan Schneider -- Detection and characterization of transcription termination / Ghada Ghazal, Jules Gagnon, and Sherif Abou Elela -- Promoter-associated noncoding RNA from the CCND1 promoter / Xiaoyuan Song [and others].
  • 2005/2006
    Kaelin, Christopher Bryan.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008
    Collins, Patrick J.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006/2007
    Schaevitz, Laura Rose.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006
    Rieger, Kerri E.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013
    Foley, Joseph William; Baker, Julie C.; Fire, Andrew Z.; Sherlock, Gavin; Sidow, Arend.
    The human genome's nucleotide sequence contains a small amount of information relative to the complexity of the organism. The diversity of developmental programs and stimulus responses is instead enabled by a vast regulatory network of chemical modifications and protein interactions that determine the activity level of each genome element dynamically. Recent advances in molecular profiling techniques have led to the creation of large data sets that assay each regulatory interaction across the entire genome at once, with high sensitivity and precision. Here I introduce a new computational method, UniPeak, that synthesizes the output from any number of these experiments into a single straightforward analysis with rigorous quantitative measures. I then apply this method to the largest available data sets of genome regulation experiments, and integrate them with parallel experiments on genome activity. I discover and characterize novel regulatory interactions, and model how these interactions regulate the activity of genes.
  • 2016 Springer
    Wu, Jiaqian.
    The Analyses of Global Gene Expression and Transcription Factor Regulation -- Global Approaches to Alternative Splicing and its Regulation -- Recent Advances and Open Questions -- Long Non-coding RNAs: Critical Regulators for Cell Lineage Commitment in the Central Nervous System -- Gene expression models of signaling pathways -- From Gene Expression to Disease Phenotypes: Network-Based Approaches to Study Complex Human Diseases -- Introduction to Isoform Sequencing using Pacific Biosciences Technology (Iso-Seq) -- Systematic and Integrative Analysis of Gene Expression to Identify Feature Genes Underlying Human Diseases.
  • 2011 CRCnetBASE
    Banga, Ajay K.
    "Skin, once thought to be an impenetrable barrier, is an extremely active organ capable of interacting with its environment. Advancements in science combined with the need for diverse drug delivery modalities have introduced a variety of transdermal and intradermal products for existing drugs at a fraction of the cost of new drug development. Commercialization of transdermal drug delivery requires technology from many disciplines beyond pharmaceutical sciences, such as polymer chemistry, adhesion sciences, mass transport, web film coating, printing, and medical technology. A comprehensive discussion of these technologies and practices, Transdermal and Intradermal Delivery of Therapeutic Agents: Application of Physical Technologies, covers: Commercial development of devices and products based on transdermal physical enhancement technologies, Selecting optimal enhancement technology for a specific drug molecule using case studies that cover physicochemical properties as well as practical commercial considerations related to cost, unmet clinical needs, marketing, or intellectual property protection, Technologies such as microneedles, iontophoresis, electroporation, and sonophoresis with examples for delivery of small molecules, cosmeceuticals, proteins, and vaccines, Practical information on experimental procedures and challenges related to skin irritation and safety issues. Up-to-date and accessible to researchers and industry experts, this book provides a comprehensive discussion of the physical approaches and practical considerations for the laboratory and marketplace"--Provided by publisher.
  • 2015 Springer
    Tan, Kok-Yang.
    This book discusses in depth the transdisciplinary integration of different components of care in colorectal surgery. Pertinent background information on the complexities of current management in colorectal surgery is first provided, followed by discussion of the role of design thinking in care integration. Subsequent chapters focus on a range of issues associated with surgical and perioperative care in patients undergoing colorectal surgery, with emphasis on how the multiple facets of care can be integrated through a transdisciplinary approach. Each chapter provides helpful take-home messages in bullet point form and numerous informative figures and tables are also included. The authors are surgeons, physicians, anesthetists, oncologists, nurses, and allied health professionals with extensive experience in the field.
  • 2013 ebrary
    Haire-Joshu, Debra; McBride, Timothy D.
    ""This book makes a great leap in the conceptualization of transdisciplinary approaches, as well as provides concrete examples in practice, teaching, policy, and research."" -From the Foreword by Edward F. Lawlor, dean and the William E. Gordon Distinguished Professor, the Brown School; and founding director, Institute for Public Health at Washington University in St. Louis The complexity of public health and social problems is becoming more challenging. Understanding and designing solutions for these problems requires perspectives from multiple disciplines and fields as well
  • 2011 ClinicalKey
    Bradshaw, Ralph A.; Dennis, Edward A.
    "Cell signaling, which is also often referred to as signal transduction or, in more specialized cases, transmembrane signaling, is the process by which cells communicate with their environment and respond temporally to external cues that they sense there. All cells have the capacity to achieve this to some degree, albeit with a wide variation in purpose, mechanism, and response. At the same time, there is a remarkable degree of similarity over quite a range of species, particularly in the eukaryotic kingdom, and comparative physiology has been a useful tool in the development of this field. The central importance of this general phenomenon (sensing of external stimuli by cells) has been appreciated for a long time, but it has truly become a dominant part of cell and molecular biology research in the past three decades, in part because a description of the dynamic responses of cells to external stimuli is, in essence, a description of the life process itself. This approach lies at the core of the developing fields of proteomics and metabolomics, and its importance to human and animal health is already plainly evident"--Provided by publisher.
  • 2006 Springer
    Resch, Klaus D. M.
  • 2014 Springer
    Miller-Hance, Wanda C.; Silverman, Norman H.; Wong, Pierre C.
    Transesophageal echocardiography (TEE) has played an instrumental role among the many advances in the field of congenital heart disease (CHD) that have resulted in successful and continually improving clinical outcomes, today enabling most affected infants and children to live well into adulthood. Ongoing evolution of the technology (including three-dimensional TEE) promises to maintain this imaging approach at the forefront of clinical practice. Competent performance of TEE in the patient with CHD, however, requires a number of essential technical and cognitive skills, in addition to a solid understanding of the broad spectrum of congenital pathology. Thus, the important need for a comprehensive reference on the subject to assist specialists who care for these patients. Transesophageal Echocardiography for Congenital Heart Disease represents a unique work, the only textbook of its kind that focuses specifically upon the applications of TEE in CHD. In each chapter, the contributorshighly regarded specialists and leaders in the fieldprovide practical and instructive information on the many different aspects of CHD evaluation by TEE. The textbook is extensively supplemented with over 700 figures/illustrations and more than 400 high quality videos (available online). This reference will prove an invaluable resource for those who use TEE in the care of both children and adults with CHD, whether they be cardiologists, surgeons, anesthesiologists, intensivists, sonographers, or trainees wishing to obtain basic knowledge or advance their understanding of the field.
  • 2009 Springer
    Belham, Mark.
    Introduction -- The left ventricle -- The left atrium -- The mitral valve -- The aortic valve and aorta -- The right heart -- Artificial valves.
  • 2008 Springer
    v. 2 2008 Springer
    Jakowlew, Sonia B.
    v. 1. Basic and clinical biology -- v. 2. Cancer treatment and therapy.
  • 2013 ebrary
    Maccoby, Michael.
    "Health care organizations are challenged to improve care at the bedside for patients, learn from individual patients to improve population health, and reduce per capita costs. To achieve these aims, leaders are needed in all parts of the organization need positive solutions. Transforming Health Care Leadership provides healthcare leaders with the knowledge and tools to master the unprecedented level of change that health care organizations and their leaders now face. It also challenges management myths that served in bureaucracies but mislead in learning organizations"--Provided by publisher.
  • 2010 Springer
    Ash, Joan S.; Einbinder, Jonathan; Einbinder, Laura; Gadd, Cynthia S.; Lorenzi, Nancy M.
    Back breaking work: implementing a spine registry in an orthopedic clinic / Brian C. Crolet -- A RHIO struggling to form: will it get off the ground? / Paul Zlotnik, Denny Lee, Mike Minear, and Prashila Dullabh -- A rough ride at the Theodore Roosevelt Cancer Center / Karen Albert, Nitika Gupta, Teresa Mason, Purvi Mehta -- Implementation of an electronic prescription writer in ambulatory care / Minhui Xie and Keven B. Johnson -- Online health care: a classic clash of technology, people and processes / John Butler, Dan Dalan, Brian McCourt, John Norris, and Randall Stewart -- A dungeon of dangerous practices / Andrew Amata, Allen Flynn, Michelle Morgan, Teresa Smith, and Mary Tengdin -- Different sides of the story / Allison B. McCoy -- Barcode medication administration implementation in the FIAT Health System / Linda Chan, William Greeley, Don Klingen, Brian Machado, Michael Padula, John Sum, and Angela Vacca -- H.I.T. or Miss / James McCormack, Bimal R. Desai, Jennifer Garvin, Randal Hamric, Kirk Lalwani, Andi Lushag, Alexey Panchenko, Deborah Quitmeyer, and JoAnna M. Vanderhoef -- The implementation of secure messaging / Zhou Yan -- Who moved my clinic? Donnelly University Pediatric Rehabilitation : the wheelchair clinic / Fredrick Hilliard -- OncoOrders: The early years / Chris Raggio and Judith W. Dexheimer -- Implementing a computerized triage system in the emergency department / Scott R. Levin, Daniel J. France, and Dominik Aronsky -- Medication barcode scanning: Code "Moo": dead COW / Laurie L. Novak and Kathy S. Moss -- Project NEED: new efficiency in an emergency department / Barry Little, Denise Johnson, Jennifer Tingle, Mary Stanfill, and Michael Roy. -- Digital radiology divide at McKinly / Neal Goldstein, David Ross, Ken Christensen, Jayashree Kalpathy-Cramer, Aseem Kumar, and Marilyn Schroeder.
  • 2015 Springer
    Juffermans, Nicole P.; Walsh, Timothy S.
    In the last decade, there have been several clinical trials that have studied red blood cell transfusion triggers in various Intensive Care Unit patient populations. Moreover, critically ill patients often suffer from coagulopathy. Recent studies have addressed the effectiveness of fresh frozen plasma and platelets to prevent or treat bleeding. This book offers a comprehensive summary of transfusion triggers for red blood cells in specific ICU patient populations and specific conditions with the aim to personalize transfusion strategy. In addition, it discusses evidence for triggers for plasma and platelets and outlines the most common adverse effects of blood transfusion in the ICU, underlining the need for a careful assessment of its risks and benefits. Transfusion in the Intensive Care Unit is a practical handbook that can be used in everyday practice to guide transfusion and thus will serve as a valuable resource for physicians, fellows and residents working in Intensive Care, Anesthesiology, and Cardiac Surgery.
  • 2012 Springer
    Mijovic, Aleksandar.
  • 2013 ClinicalKey
    Abrams, Charles Samuel; Hillyer, Christopher D.; Roshal, Mikhail; Shaz, Beth.
    The second edition of Transfusion Medicine and Hemostasis continues to be the only "pocket-size" quick reference for pathology residents and transfusion medicine fellows. It covers all topics in blood banking, transfusion medicine, and clinical and laboratory based coagulation. Short, focused chapters, organized by multiple hierarchical headings, are supplemented with up to 10 suggested reading citations. This single reference covers essentially all the topics required to meet the goals and objectives of a major program in transfusion medicine and clinical coagulation. New chapters in the coagulation testing section reflect the development of new tests available and their incorporation into clinical practice. Coverage includes essential updates on the importance of new cellular therapies, peripheral blood and bone marrow hematopoietic progenitor cells, as well as cord blood banking and regenerative medicine. The authors also examine advances in the understanding of molecular testing and pathogen reduction in two separate quality control chapters (one for blood centers and one for hospitals). Updated content covers new coagulation tests, cellular therapies, and quality control issuesEasy to use, with focused, well-defined chapters in a standardized format throughoutOffers quick "cross-reference" lists at the end of each chapter Includes lists of common abbreviations and indexes that cross reference diagnostic, clinical and therapeutic commonalities.
  • 2009 ScienceDirect
    Abshire, Thomas C.; Hillyer, Christopher D.; Shaz, Beth; Zimring, James C.
  • Aksoy, Serap.
    Perspectives on the state of insect transgenics / David A. O'Brochta and Alfred M. Handler -- Alphavirus transducing systems / Brian D. Foy and Ken E. Olson -- Paratransgenesis applied for control of tsetse transmitted sleeping sickness / Serap Aksoy, Brian Weiss, and Geoffrey Attardo -- Bacteria of the genus Asaia: a potential paratransgenic weapon against malaria / Guido Favia ... [et al.] -- Proposed uses of transposons in insect and medical biotechnology / Peter W. Atkinson -- The yin and yang of linkage disequilibrium: mapping of genes and nucleotides -- Conferring insecticide resistance in insect disease vectors / William C. Black IV ... [et al.] -- Impact of technological improvements on traditional control strategies / Mark Q. Benedict and Alan S. Robinson -- Insect population suppression using engineered insects / Luke Alphey ... [et al.] -- Wolbachia-based technologies for insect pest population control / Kostas Bourtzis -- Using predictive models to optimize wolbachia-based strategies for vector-borne disease control / Jason L. Rasgon -- Modifying insect population age structure to control vector-borne disease / Peter E. Cook, Conor J. McMeniman, and Scott L. O'Neill -- Technological advances to enhance agricultural pest management / Thomas A. Miller, Carol R. Lauzon, and David J. Lampe -- Applications of mosquito ecology for successful insect transgenesis-based disease prevention programs / Thomas W. Scott ... [et al.].
  • 2006 Springer
    Fisch, Gene S.; Flint, Jonathan.
    Transgenic and knockout models of psychiatric disorders: introduction, history, and assessment / Gene S. Fisch -- Transgenic mouse models and human psychiatric disease / Jonathan Flint -- Transgenic and knockout mouse models: the problem of language / Linda J. Hayes and Diana Delgado -- If only they could talk: genetic mouse models for psychiatric disorders / Trevor Humby and Lawrence Wilkinson -- Spinocerebellar ataxia type 1: lessons from modeling a movement disease in mice / Harry T. Orr -- Mouse models of hereditary mental retardation / Hans Welzl ... [et al.] -- How can studies of animals help to uncover the roles of genes implicated in human speech and language disorders? / Simon E. Fisher -- Animal models of autism: proposed behavioral paradigms and biological studies / Thomas Bourgeron, Stéphane Jamain, and Sylvie Granon -- Genetic mouse models of psychiatric disorders: advantages, limitations, and challenges / Joseph A. Gogos and Maria Karayiorgou -- Animal models of psychosis / Stephen I. Deutsch ... [et al.] -- Animal models of anxiety: the ethological perspective / Robert Gerlai, Robert Blanchard, and Caroline Blanchard -- Modeling human anxiety and depression in mutant mice / Andrew Holmes and John F. Cryan -- Mutant mouse models of bipolar disorder: are there any? / Anneloes Dirks, Lucianne Groenink, and Berend Olivier.
  • 2010 Springer Protocols
    Bergner, Carisa L.; Kalueff, Allan V.
    Mutant and transgenic zebrafish in modeling neurobehavioral disorders / C.L. Bergner [and others] -- Knockout and mutant rats / M. Müller, J. Olivier and J. Homberg -- Rat mutants with lateralized rotational behavior for studying disturbances in cerebral asymmetries and their involvement in brain disorders / W. Löscher -- GABAA receptor [alpha]1 subunit (Gabra1) knockout mice: Review and new results / G.-L. Ye [and others] -- Basal ganglia disorders in genetic models and experimentally induced lesions / R. Lalonde and C. Strazielle -- Estrogen-deficient mouse models in the study of brain injury and disease / R.A. Hill and W.C. Boon -- The utility of genetically modified animals in modeling OCD-spectrum disorders / A.N. Smolinsky [and others] -- Investigating Rett syndrome through genetic mouse models: Presymptomatic, clearly symptomatic phases, and innovative therapeutic approaches / B. Filippis, L. Ricceri and G. Laviola -- Genetic animal models of anxiety / R.J. Egan [and others] -- Genetic animal models of depression / P.R. Canavello [and others] -- Environmental enrichment and gene-environment interactions in mouse models of brain disorders / A.J. Hannan -- Mutant and transgenic tools in modeling schizophrenia / L. Desbonnet [and others].
  • 2006
    Bitsch, Annette; Kielhorn, J.; Mangelsdorf, Inge; Wahnschaffe, U.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer Protocols
    Zhang, Baohong.
    Transgenic cotton : from biotransformation methods to agricultural application / Baohong Zhang -- Genetically modified cotton in India and detection strategies / Gurinder Jit Randhawa and Rashmi Chhabra -- Agrobacterium-mediated transformation of cotton / Baohong Zhang -- Biolistic transformation of cotton zygotic embryo meristem / Kanniah Rajasekaran -- Biolistic transformation of cotton embryogenic cell suspension cultures / Kanniah Rajasekaran -- Cotton transformation via pollen tube pathway / Min Wang, Baohong Zhang, and Qinglian Wang -- Silicon carbide whisker-mediated transformation of cotton (Gossypium hirsutum L.) / Muhammad Arshad, Yusuf Zafar, and Shaheen Asad -- Investigating transgene integration and organization in cotton (Gossypium hirsutum L.) genome / Jun Zhang and Yan Hong -- Estimating the copy number of transgenes in transformed cotton by real-time quantitative PCR / Chengxin Yi and Yan Hong -- Development of enzyme-linked immunosorbent assay for the detection of Bt protein in transgenic cotton / Suchitra Kamle, Abhishek Ojha, and Arvind Kumar -- DNA-based diagnostics for genetically modified cotton : decaplex PCR assay to Differentiate MON531 and MON15985 Bt cotton events / Gurinder Jit Randhawa, Monika Singh, and Rashmi Chhabra -- Simple and rapid method for determining transgenic cotton plants / Baohong Zhang [and others] -- Efficient grafting technique for recovery of transgenic cotton plants / Min Wang, Qinglian Wang, and Baohong Zhang -- Inheritance of transgenes in transgenic Bt lines resistance to Helicoerpa armigera in upland cotton / Baolong Zhang, Wangzhen Guo, and Tianzhen Zhang -- Agrobacterium rhizogenes-induced cotton hairy root culture as an alternative tool for cotton functional genomics / Hee Jin Kim -- Overexpression of miR 156 in cotton via Agrobacterium-mediated transformation / Baohong Zhang [and others] -- Development of transgenic CryIA(c) + GNA cotton plants via pollen tube pathway method confers resistance to Helicoverpa armigera and Aphis gossypii Glover / Zhi Liu, Zhen Zhu, and Tianzhen Zhang -- Agrobacterium-mediated transformation of cotton (Gossypium hirsutum) shoot apex with a fungal phytase gene improves phosphorus acquisition / Zhiying Ma, Jianfeng Liu, and Xingfen Wang -- Genetic transformation of cotton with a harpin-encoding gene hpaXoo confers an enhanced defense response against Verticillium dahliae kleb / Weiguo Miao and Jingsheng Wang -- Development of insect-resistant transgenic cotton with chimeric TVip3A* accumulating in chloroplasts / Jiahe Wu and Yingchuan Tian -- Determining gene flow in transgenic cotton / Xiaoping Pan.
  • 2007
    Fernández, Emilio; Gaván, Aurora; León, Rosa.
    In the grip of algal genomics / Arthur R. Grossman -- Insertional mutagenesis as a tool to study genes/functions in chlamydomonas / Aurora Gaván, David González-Ballester, and Emilio Fernández -- Optimization of recombinant protein expression in the chloroplasts of green algae / Samuel P. Fletcher, Machiko Muto, and Stephen P. Mayfield -- Nuclear transformation of eukaryotic microalgae : historical overview, achievements, and problems / Rosa León and Emilio Fernández -- Transformation of cyanobacteria / Agustín Vioque -- Molecular biology and the biotechnological potential of diatoms / Peter Kroth -- Tools and techniques for chloroplast transformation of chlamydomonas / Saul Purton -- Phycoremediation of heavy metals using transgenic microalgae / Sathish Rajamani ... [et al.] -- Hydrogen fuel production by transgenic microalgae / Anastasios Melis, Michael Seibert, and Maria L. Ghirardi -- Microalgal vaccines / Surasak Siripornadulsil, Konrad Dabrowski, and Richard Sayre.
  • 2011 Springer Protocols
    Deursen, Jan van; Hofker, Marten H.
    Introduction: strategies for developing genetically modified mice / Marten H. Hofker -- Genetic modification of the mouse: general technology - pronuclear and blastocyst injection / Jan Willem Voncken -- Generation of chimeras by aggregation of embryonic stem cells with diploid or tetraploid mouse embryos / Jérôme Artus and Anna-Katerina Hadjantonakis -- Cryopreservation of mouse spermatozoa and in vitro fertilization / Naomi Nakagata -- Autopsy and histological analysis of the transgenic mouse / Marion J.J. Gijbels and Menno P.J. de Winther -- Transgene design / Bart van de Sluis and Jan Willem Voncken -- Inducible transgenic mouse models / Thomas L. Saunders -- Lentiviral transgenesis / Terunaga Nakagawa and Casper C. Hoogenraad -- Transgenesis in mouse embryonic stem cells / Janine van Ree, Wei Zhou, Ming Li, and Jan M. van Deursen -- Engineering BAC reporter gene constructs for mouse transgenesis / Yu Fu and Peter Maye -- Targeting vector construction through recombineering / Liviu A. Malureanu -- Generating conditional knockout mice / Roland H. Friedel, Wolfgang Wurst, Benedikt Wefers, and Ralf Kühm -- Hypomorphic mice / Darren J. Baker -- MICER targeting vectors for manipulating the mouse genome / Chunbong Liu, Paul F. Szurek, and Y. Eugene Yu -- Knock-in approaches / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Generation of a series of knock-in alleles using RMCE in ES cells / Anton J.M. Roebroek, Philip L.S.M. Gordts, and Sara Reekmans -- Selection of targeting mutants from a library of randomly mutagenized ES cells / Kyoji Horie, George Gaitanaris, and Alexander Gragerov -- Generation of genetically modified rodents using random ENU mutagenesis / Ruben van Boxtel and Edwin Cuppen -- Bone marrow transplantations of study gene function in hematopoietic cells / Menno P.J. de Winther and Peter Heeringa -- Adenovirus-mediated gene transfer / Ko Willems van Dijk, Kyriakos E. Kyreos, Frits J. Fallaux, and Jurre Hageman.
  • 2009 Springer Protocols
    Jones, Huw D.; Shewry, P. R.
    Transgenic wheat, barley and oats : production and characterization / Paul A. Lazzeri and Huw D. Jones -- Selection of transformed plants / Huw D. Jones and Caroline A. Sparks -- Reporter genes / Alison Huttly -- Biolistics transformation of wheat / Caroline A. Sparks and Huw D. Jones -- Agrobacterium-mediated transformation of bread and durum wheat using freshly isolated immature embryos / Huixia Wu, Angela Doherty and Huw D. Jones -- Floral transformation of wheat / Sujata Agarwal ... [et al.] -- Highly efficient agrobacterium-mediated transformation of wheat via in planta inoculation / Thierry Risacher ... [et al.] -- Barley transformation using biolistic techniques / Wendy A. Harwood and Mark A. Smedley -- Barley transformation using agrobacterium-mediated techniques / Wendy A. Harwood ... [et al.] -- Transformation of oats and its application to improving osmotic stress tolerance / Shahina B. Maqbool ... [et al.] -- Promoter sequences for defining transgene expression / Huw D. Jones and Caroline A. Sparks -- Down-regulation of gene expression by RNA-induced gene silencing / Silvia Travella and Beat Keller -- Gene insertion patterns and sites / Philippe Vain and Vera Thole -- Fluorescent in situ hybridization to detect transgene integration into plant genomes / Trude Schwarzacher -- Establishing substantial equivalence : transcriptomics / María Marcela Baudo ... [et al.] -- Establishing substantial equivalence : proteomics / Alison Lovegrove, Louise Salt, and Peter R. Shewry -- Establishing substantial equivalence : metabolomics / Michael H. Beale, Jane L. Ward, and John M. Baker -- Design and management of field trials of transgenic cereals / Zoltán Bedő, Mariann Rakszegi, and László Láng -- GM risk assessment / Penny A.C. Sparrow -- Transgenic wheat, barley and oats : future prospects / Jim M. Dunwell.
  • 2005 Karger
    Eckert, Richard; Mehta, Kapil.
    Mammalian transglutaminases : a family portrait / Mehta, K. -- Structure-function relationships of transglutaminases, a contemporary view / Nemes, Z., Csosz, E., Fesus, L. -- Transglutaminases and their substrates / Facchiano, F., Facchiano, A. -- Type 2 transglutaminase and cell death / Piacentini, M. ... [et al.] -- Transglutaminase and cell-survival signaling / Singh, U.S., Pan, J. -- Transglutaminases in wound healing and inflammation / Verderio, E.A.M., Johnson, T.S., Griffin, M. -- Transglutaminases in epidermis / Eckert, R.L. ... [et al.] -- Tissue transglutaminase (TG2) in cancer biology / Mangala, L.S., Mehta, K. -- Transglutaminases in neurodegenerative disorders / Bailey, C.D.C., Tucholski, J., Johnson, G.V.W. -- Tissue transglutaminase and celiac disease / Esposito, C. ... [et al.] -- Transglutaminases as biotechnological tools / Mariniello, L., Porta, R. -- Extracellular transglutaminase: factor XIII / Ichinose, A. -- Transglutaminases of lower organisms / Rao, R.U., Chandrashekar, R., Mehta, K. -- Transglutaminases of higher, lower plants and fungi / Del Duca, S., Serafini-Fracassini, D.
  • 2013 Wiley
    More, Max; Vita-More, Natasha.
    The first authoritative and comprehensive survey of the origins and current state of transhumanist thinking The rapid pace of emerging technologies is playing an increasingly important role in overcoming fundamental human limitations. Featuring core writings by seminal thinkers in the speculative possibilities of the posthuman condition, essays address key philosophical arguments for and against human enhancement, explore the inevitability of life extension, and consider possible solutions to the growing issues of social and ethical implications and concerns.
  • 2011 Springer
    Islam, Md. Shahidul.
    Also available: Print – 2011
  • 2007 Springer
    Abramowitz, J.; Flockerzi, Veit; Nilius, Bernd.
  • 2015 Springer
    Wood, Dan; Wood, Hadley M.
    1. The transition process: initial assessment and development of a treatment plan -- 2. Approach to the myelodysplasia patient -- 3. Approach to the exstrophy patient -- 4. Approach to the adult hypospadias patient -- 5. Sexual function and pregnancy in the female myelodyspasia patient -- 6. Revision genitoplasty, sexual function, fertility, and pelvic organ prolapse in exstrophy and the management of pregnancy -- 7. Issues in the long-term management of adolescents and adults with DSD: management of gonads, genital reconstruction, and late presentation of the undiagnosed DSD -- 8. The adult hypospadias patient: technical challenges in adulthood -- 9. Urinary tract infections in the reconstructed bladder: evaluation and treatment options -- 10. Troubleshooting continent catheterizable channels -- 11. Augmentation cytosplasty: risks for malignancy and suggestions for follow-up evaluations -- 12. BPH and pelvic organ prolapse in patients with neurogenic bladder -- 13. Posterior urethral valves in adolescents: clinical problems, management, and follow-up -- 14. Renal transplantation in patients with lower urinary tract dysfunction -- 15. Management of calculi in patients with congenital neuropathic bladder -- 16. Vesicoureteral reflux and the adult -- 17. Adult survivors of pediatric genitourinary tumors -- Index.
  • 2010
    Rondinelli, Robert D.; Eskay-Auerbach, Marjorie.
    PrintStatus: Not Checked OutLane Catalog Record
    Conceptual foundations and philosophy -- Practical application of the guides -- Pain-related impairment -- The cardiovascular system -- The pulmonary system -- The digestive system -- The urinary and reproductive systems -- The skin -- The hematopoietic system -- The endocrine system -- Ear, nose, throat, and related structures -- The visual system -- The central and peripheral nervous system -- Mental and behavioral disorders -- The upper extremities -- The lower extremities -- The spine and pelvis.
  • 2015
  • 2003 Stanf Univ SOM
  • 2013 Springer
    Duchêne, Anne-Marie.
    Insights into Structural Basis of Mammalian Mitochondrial Translation / Manjuli R. Sharma, Prem S. Kaushal -- Mechanism and Regulation of Protein Synthesis in Mammalian Mitochondria / Emine C. Koc, Hasan Koc -- Translation in Mammalian Mitochondria: Order and Disorder Linked to tRNAs and Aminoacyl-tRNA Synthetases / Catherine Florentz, Joern Pütz -- Mitochondrial Targeting of RNA and Mitochondrial Translation / Ivan Tarassov, Ivan Chicherin, Yann Tonin -- Mechanisms and Control of Protein Synthesis in Yeast Mitochondria / Steffi Gruschke, Martin Ott -- Kinetoplast-Mitochondrial Translation System in Trypanosomatids / Dmitri A. Maslov, Rajendra K. Agrawal -- Translation in Mitochondria and Apicoplasts of Apicomplexan Parasites / Ankit Gupta, Afreen Haider, Suniti Vaishya -- Mitochondrial Translation in Green Algae and Higher Plants / Thalia Salinas, Claire Remacle -- Translation in Chloroplasts of Flowering Plants / Masahiro Sugiura -- The Chloroplasts as Platform for Recombinant Proteins Production / Nunzia Scotti, Michele Bellucci.
  • 2007 ScienceDirect
    Lorsch, Jon.
    Purification of FLAG-tagged eukaryotic initation factor 2B complexes, subcomplexes, and fragments from Saccharomyces cerevisiae / Sarah S. Mohammad-Qureshi ... [et al.] -- In vivo deletion analysis of the architecture of a multiprotein complex of translation initiation factors / Klaus H. Nielsen and Leos̆ Valás̆ek -- An approach to studying the localization and dynamics of eukaryotic translation factors in live yeast cells / Susan G. Campbell and Mark P. Ashe -- In vitro and tissue culture methods for analysis of translation initiation on the endoplasmic reticulum / Samuel B. Stephens and Christopher V. Nicchitta -- Mammalian stress granules and processing bodies / Nancy Kedersha and Paul Anderson -- Methods to analyze micro-RNA-mediated control of mRNA translation / Jennifer L. Clancy ... [et al.] -- Methods for studying signal-dependent regulation of translation factor activity / Xuemin Wang and Christopher G. Proud -- Analysis of mRNA translation in cultured hippocampal neurons / Yi-Shuian Huang and Joel D. Richter -- Detecting ribosomal association with the 5' leader of mRNAs by ribosome density mapping (RDM) / Naama Eldad and Yoav Arava -- Genome-wide analysis of mRNA polysomal profiles with spotted DNA microarrays / Danial Melamed and Yoad Arava -- Synthesis of anti-reverse cap analogs (ARCAs) and their applications in mRNA translation and stability / Ewa Grudzien-Nogalska ... [et al.] -- Methods for identifying compounds that specifically target translation / Letizia Brandi ... [et al.] -- Identifying small molecule inhibitors of eukaryotic translation initiation / Regina Cencic, Francis Robert, and Jerry Pelletier -- Isolation and identification of eukaryotic initiation factor 4A as a molecular target for the marine natural product pateamine A / Woon-Kai Low ... [et al.].
    Also available: Print – 2007
  • 2007 ScienceDirect
    Lorsch, Jon.
    Use of reticulocyte lysates for mechanistic studies of eukaryotic translation initiation / William C. Merrick and Diane Barth-Baus -- Studying translational control in Drosophila cell-free systems / Fátima Gebauer and Matthias W. Hentze -- Use of in vitro translation extract depleted in specific initiation factors for the investigation of translational regulation / Daniel R. Gallie -- A highly efficient and robust in vitro translation system for expression of picornavirus and hepatitis C virus in RNA genomes / Yuri V. Svitkin and Nahum Sonenberg -- A practical approach to isolate 48S complexes : affinity purification and analyses / Nicolas Locker and Peter J. Lukavsky -- Yeast phenotypic assays on translational control / Bumjun Lee ... [et al.] -- Localization and characterization of protein-protein interaction sites / Chingakham Ranjit Singh and Katsura Asano -- In vivo stabilization of preinitiation complexes by formaldehyde cross-linking / Leos Valás̆ek ... [et al.] -- Molecular genetic structure-function analysis of translation initiation factor elF5B / Byung-Sik Shin and Thomas E. Dever -- The use of fungal in vitro systems for studying translational regulation / Cheng Wu ... [et al.] -- Investigating translation initiation using drosophila molecular genetics / Gritta Tettweiler and Paul Lasko -- Analysis of RNA:protein interactions in vivo : identification of RNA-binding partners of nuclear factor 90 / Andrew M. Parrott, Melissa R. Walsh, and Michael B. Mathews -- Approaches for analyzing the differential activities and functions of elF4E family members / Robert E. Rhoads, Tzvetanka D. Dinkova, and Rosemary Jagus -- Tethered function assays : an adaptable approach to study RNA regulatory proteins / Jeff Coller and Marv Wickens -- Analysis of ribosomal shunting during translation initiation in eukaryotic mRNAs / Vincent P. Mauro, Stephen A. Chappell and John Dresios.
    Also available: Print – 2007
  • 2007 ScienceDirect
    Lorsch, Jon.
    Transient kinetics, flourescence, and FRET in studies of initiation and translation in bacteria / Pohl Milon ... [et al.] -- Binding of mRNA to the bacterial translation initiation complex / Sean M. Studer and Simpson Joseph -- Real-time dynamics of ribosome-ligand interaction by time-resolved chemical probing methods / Attilio Fabbretti ... [et al] -- Overexpression and purification of mammalian mitochondrial translational initiation factor 2 and initiation factor 3 / Domenick G. Grasso ... [et al.] -- In vitro studies of archaeal translational initiation / Dario Benelli and Paola Londei -- Reconstitution of yeast translation initiation / Michael G. Acker ... [et al.] -- Assembly and analysis of eukaryotic translation initiation complexes / Andrey V. Pisarev -- Reconstitution of mammalian 48S ribosomal translation initiation complex / Romit Majumdar, Jayanta Chaudhuri, and Umadas Maitra -- Biophysical approach to studies of Cap-elF4E interaction by synthetic cap analogs / Anna Niedzwiecka ... [et al.] -- Biophysical studies of the translation initiation pathway with immobilized mRNA analogs / John E. G. McCarthy, Steven Marsden, and Tobias von der Haar -- Protection-based assays to measure aminoacyl-tRNA binding to translation initiation factors / Yves Mechulam ... [et al.] -- NMR methods for studying protein-protein interactions involved in translation initiation / Assen Marintchev, Dominique Frueh, and Gerhard Wagner -- Structural methods for studying IRES function / Jeffrey S. Kieft ... [et al.].
    Also available: Print – 2007
  • 2013 Springer
    Bartunek, Jozef; Vanderheyden, Marc.
    Pathophysiology of Heart Failure: Back to Basics -- Heart Failure with Normal Left Ventricular Ejection Fraction -- Basic Principles and Clinical Diagnostics -- 17 Cardiorenal Syndrome Revisited -- Doppler Echocardiography in the Clinical Evaluation of Heart Failure: What Clinicians Need to know and Echocardiographers Should Report -- Back to Earth: 'Common sense' in the Management of Heart Failure -- Atrial Fibrillation and Heart Failure: Rate versus Rhythm Control -- Repetitive ICD Shocks and Incessant VTs in Heart Failure: What to Do? -- Dyssynchronous Heart Failure: From Bench to Bedside -- 18 Telemonitoring and Sensor Technologies in Chronic Heart Failure -- Functional Mitral Regurgitation: the Surgeons's Perspective -- Percutaneous Approaches to Treat Functional Mitral Regurgitation: Current State of Affairs and Future Perspectives -- Tailored Approach to Functional Mitral Regurgitation -- Revascularization and Left Ventricular Reconstruction in a Patient with Ischemic Heart Failure: to STICH or not to STICH? -- Cardiac arrest en Refractory Cardiogenic Shock -- Left Ventricular Assist Devices -- From Bridge to Transplant to Destination Therapy -- Novel Device-based Strategies in Treatment of Chronic Heart Failure -- Total Artificial Heart -- Stem Cell Therapy for Ischemic Heart Disease -- Immunosuppressive Management of the Heart Transplant Recipient.
  • v. 1-, 2012- Springer
    Wang, Xiangdong.
  • 2015 ScienceDirect
    Montano, Monty.
  • Hershey, John W. B.; Mathews, Michael B.; Sonenberg, Nahum.
  • 2015 Springer
    Embi, Peter J.; Payne, Philip R. O.
    Pt. I. The rationale for translational informatics -- An introduction to translational informatics and the future of knowledge-driven healthcare -- A prototype of translational informatics in action -- pt. II. Foundations of translational informatics -- Personalized medicine -- Leveraging electronic health records for phenotyping -- Mining the bibliome -- pt. III. Applications of translational informatics -- Driving clinical and translational research using biomedical informatics -- Using big data -- In silico hypothesis discovery -- Patient engagement and consumerism -- pt. IV. The future of translational informatics and knowledge-driven healthcare -- Future directions for translational informatics.
  • 2009 CRCnetBASE
    Chow, Shein-Chung; Cosmatos, Dennis.
    Chapter 1. Translational Medicine / Dennis Cosmatos, Shein-Chung Chow -- Chapter 2. Strategic Concepts in Translational Medicine / Dennis Cosmatos, Giora Feuerstein, Shein-Chung Chow -- Chapter 3. Design and Analysis Approaches for Discovery Translational Medicine / Dennis Cosmatos, Shein-Chung Chow (Eds.), Stephen B. Forlow, Jennifer A. Isler, Zhaosheng Lin, Michael E. Burczynski, Jessie Q. Xia, S. Stanley Young -- Chapter 4. Biomarker Development / Mark Chang -- Chapter 5. Targeted Clinical Trials / Jen-pei Liu -- Chapter 6. Statistical Methods in Translational Medicine / Shein-Chung Chow, Siu-Keung Tse, Dennis Cosmatos -- Chapter 7. Nonparametric Methods in Translational Research / Kongming Wang, Shein-Chung Chow -- Chapter 8. Model Selection/Validation / Jen-pei Liu -- Chapter 9. Translation in Clinical Information between Populations-Bridging Studies / Chin-Fu Hsiao, Mey Wang, Herng-Der Chern, Jen-pei Liu -- Chapter 10. Translation in Clinical Technology-Traditional Chinese Medicine / Chin-Fu Hsiao, Hsiao-Hui Tsou, Shein-Chung Chow.
  • 2013 Karger
    Alving, Barbara M.; Chan, Samuel H. H.; Dai, Kerong.
  • 2013 CRCnetBASE
    Milne, Christopher-Paul; Mittra, James.
    Chapter 1. Introduction to Translational Medicine -- Chapter 2. New Light Through an Old Window? The "Translational Turn" in Biomedical Research -- Chapter 3. Translational Medicine -- Drivers and Barriers of TM -- Chapter 5. Developing an Evaluation Model for Translational Medicine Research Programs -- Chapter 6. Emerging Concepts in Biomarker Discovery -- Chapter 7. Imaging Biomarkers for Innovative Drug Development -- Chapter 8. Translational Bioinformatics -- Chapter 9. Exploiting Translational Medicine Through Public- Private Partnerships -- Chapter 10. The Role of the Product Development Partnership as a Translational Mechanism for Delivering Health Solutions in Low- Resource Settings.
  • 2012
    Stadler, Michael Richard; Fire, Andrew Z.; Sarnow, P.; Sidow, Arend; Vollrath, Douglas E.
    The conversion of genetic information from the language of nucleic acids into that of proteins is fundamental to nearly every biological process. The regulation of this process of gene expression--when, where, and how much product is produced from each gene--is a crucial determinant of cell state and identity. Gene expression is tightly regulated at every metabolic step, including transcription of DNA into mRNA, splicing of introns, export from the nucleus, polypeptide synthesis, and post-translational modification and stability. Regulation of protein synthesis acts directly or indirectly through the ribosome, as it is the interaction of ribosomes with mRNAs and dozens of protein and RNA translation factors that determine the efficiency and fidelity of translation. Emerging technologies allow the analysis of translation in contexts that were previously inaccessible. In my thesis work, I employed a technique known as ribosome profiling to examine snapshots of the positions of millions of ribosomes on cellular mRNAs in vivo. In the first part of my thesis, I used ribosome profiling data from Caenorhabditis elegans and cultured human tumor cells to investigate the sequence determinants of the rate of ribosome elongation. The genetic code is redundant, meaning that a single amino acid can usually encoded by more than one trinucleotide sequence, or codon. The choice from among these "synonymous" codons has long been suspected to influence local ribosomal elongation rates, with possible consequences on the folding of nascent polypeptides. By examining "snapshots" of the in vivo positions of ribosomes on thousands of mRNAs, we were able to determine that mRNA positions featuring "wobble" codons in the ribosomal decoding center were associated with greater ribosome occupancy, and thus most likely with slower translation elongation. These wobble codons pair with cognate tRNA anticodons using alternative base-pairing strategies that are less energetically stable than canonical Watson-Crick interactions. The observed wobble retention was strong for codons that employ G:U pairing at the wobble position, and weaker for those using I:U pairs. Importantly, this property of translation elongation was observed in both C. elegans samples and human cells, indicating that wobble-related slowing is a conserved feature of metazoan translation. In the second part of my thesis, I used ribosome profiling, together with traditional, low-throughput methods to investigate the molecular consequences of regulation by C. elegans miRNAs. miRNAs are post-transcriptional regulators of gene expression that have been proposed to act by directing mRNA degradation, deadenylation, translation initiation, by interfering with a post-initiation stage of translation or by triggering proteolysis. C. elegans features several well-validated, natural miRNA::mRNA interactions that serve to reduce target protein levels at specific developmental time points as part of the so-called heterochronic pathway. mRNA-seq measurements confirmed earlier observations from other groups that the abundance of target mRNAs decreases only slightly upon the onset of miRNA regulation. Analysis of ribosome footprint abundance showed that miRNA regulation is often associated with decreased ribosome loading in later larval stages, but changes in ribosome loading are negligible at time points where miRNA inhibition becomes active. Additionally, profiles of ribosome footprints did not appreciably change, rendering several models of post-initiation translational regulation unlikely. These data suggest a model in which processes beyond mRNA degradation and translational repression contribute to regulation by this set of miRNAs, including a possible role for post- or peri-translational destruction of peptide products.
  • 2015 Karger
    Alonso, A.; Hennerici, M.; Meairs, Stephen P.
    Principles of cerebral ultrasound contrast imaging / Powers, J., Averkiou, M. -- Physical principles of microbubbles for ultrasound imaging and therapy / Stride, E. -- Ultrasound bio-effects and safety considerations / Ter Haar, G. -- Intima-media thickness of carotid arteries / Touboul, P.-J. -- Functional TCD : regulation of cerebral hemodynamics, cerebrovascular autoregulation, vasomotor reactivity, neurovascular coupling / Wolf, M.E. -- Intracranial perfusion imaging with ultrasound / Meairs, S., Kern, R. -- Parenchymal imaging in movement disorders / Fernandes, R.C.L., Berg, D. -- Sonothrombolysis / Meairs, S. -- Non-invasive transcranial brain ablation with high-intensity focused ultrasound / Jenne, J.W. -- Ultrasound-induced blood-brain barrier opening for drug delivery / Alonso, A.
  • 2010 CRCnetBASE
    Kruger, Lawrence; Light, Alan R.
    Painful multi-symptom disorders : a systems perspective / C. Richard Chapman -- Neurotrophic factors and nociceptor sensitization / Michael P. Jankowski and H. Richard Koerber -- The role of visceral afferents in disease / Julie A. Christianson and Brian M. Davis -- Cancer pain : from the development of mouse models to human clinical trials / Juan Miguel Jimenez Andrade and Patrick Mantyh -- Therapeutic targeting of peripheral cannabinoid receptors in inflammatory and neuropathic pain states / Igor Spigelman -- Molecular strategies for therapeutic targeting of primary sensory neurons in chronic pain syndromes / Ichiro Nishimura ... [et al.] -- Transgenic mouse models for the tracing of "pain" pathways / Allan I. Basbaum and João M. Bráz -- Cytokines in pain / Veronica I. Shubayev, Kinshi Kato, and Robert R. Myers -- Glial modulation in pain states : translation into humans / Ryan J. Horvath, Edgar Alfonso Romero-Sandoval, and Joyce A. De Leo -- On the role of ATP-gated P2X receptors in acute, inflammatory, and neuropathic pain / Estelle Toulme ... [et al.] -- Myalgia and fatigue : translation from mouse sensory neurons to fibromyalgia and chronic fatigue syndromes / Alan R. Light, Charles J. Vierck, and Kathleen C. Light -- Reflex autonomic responses evoked by group III and IV muscle afferents / Jennifer L. McCord and Marc P. Kaufman -- Central pain as a thalamocortical dysrhythmia : a thalamic efference disconnection? / Kerry D. Walton and Rodolfo R. Llinás -- What can neuroimaging tell us about central pain? / D.S. Veldhuijzen ... [et al.] -- Human brain imaging studies of chronic pain : translational opportunities / A. Vania Apkarian -- Consideration of pharmacokinetic pharmacodynamic relationships in the discovery of new pain drugs / Garth T. Whiteside and Jeffrey D. Kennedy -- Large animal models for pain therapeutic development / Darrell A. Henze and Mark O. Urban -- Drug discovery and development for pain / Sandra R. Chaplan, William A. Eckert III, and Nicholas I. Carruthers.
  • 2015 Springer
    Heinemann, Lutz; Hompesch, Marcus; Krentz, Andrew J.
    This book aims to aid the selection of the most appropriate techniques for use in early phase (1 and 2) clinical studies of new drugs for diabetes, obesity, and related cardiometabolic disease. Clinical research methods for assessing the pharmacokinetics and pharmacodynamics of new diabetes drugs, e.g. the euglycaemic clamp technique, have become well-established in proof-of-mechanism studies; however, selection of the best techniques is by no means straightforward. This book will aid the understanding of the need for new pharmacotherapies for type 1 diabetes, type 2 diabetes, and obesity and the molecular targets of drugs currently in development. Emerging technologies including the omics disciplines are considered together with practical and ethical issues of early phase clinical trials in subjects with cardiometabolic disorders. Translational Research Methods for Diabetes, Obesity and Cardiometabolic Drug Development will be of interest to biomedical scientists, pharmacologists, academics involved in metabolic research and clinicians practicing in these specialties.
  • 2011 Springer
    Hermerén, Göran; Hug, Kristina.
    For many years, the ethical discussion surrounding human embryonic stem cell research has focused on the moral status of the embryo. This text takes a wider moral berth and focuses on numerous ethical, legal and social aspects involved in translating the results of stem cell research into diagnostic and therapeutic applications.
  • 2012 Springer
    Lapchak, Paul A.; Zhang, J. H.
    Pt. 1. Theoretical overview -- pt. 2. Mechanisms and targets -- pt. 3. Translational models -- pt. 4. De-risking of drug candidates -- pt. 5. Therapy delivery -- pt. 6. Therapy development -- pt. 7. Clinical trial design.
  • 2015 ScienceDirect
    Vodovotz, Yoram; An, Gary.
    Ch. 1.1. Interesting times: the translational dilemma and the need for translational systems biology of inflammation -- Ch. 2.1. A brief history of the philosophical basis of the scientific endeavor: how we know what we know, and how to know more -- Ch. 2.2. A brief history of biomedical research up to the molecular biology revolution -- Ch. 2.3. Biomedical research since the molecular revolution: an embarrassment of riches -- Ch. 2.4. Randomized clinical trials: a bridge too far? -- Ch. 2.5. Complexity in biomedical research: mysticism versus methods -- Ch. 2.6. Human nature, politics, and translational inertia -- Ch. 3.1. Towards translational systems biology of inflammation -- Ch. 3.2. Dynamic knowledge representation and the power of model making -- Ch. 3.3. A roadmap for a rational future: a systematic path for the design and implementation of new therapeutics -- Ch. 4.1. From data to knowledge in translational systems biology: an overview of computational approaches across the scientific cycle -- Ch. 4.2. Data-driven and statistical models: everything old is new again -- Ch. 4.3. Mechanistic modeling of critical illness using equations -- Ch. 4.4. Agent-based modeling and translational systems biology: an evolution in parallel -- Ch. 4.5. Getting science to scale: accelerating the development of translational computational models -- Ch. 5.1. What is old is new again: the scientific cycle in the twenty-first century and beyond -- Index.
  • 2012 Springer
    Abraham, David.
    Section I. Hot topics in vascular biology -- Section II. Novel molecular mediators regulating cardiovascular system -- Section III. Clinical aspects of cardiovascular disease -- Section IV. Clinical and translational aspects of pulmonary vascular disease -- Index.
  • 2006 Springer Protocols
    Ali, Hydar; Haribabu, Bodduluri.
    Bioluminescence resonance energy transfer to monitor protein-protein interactions / Tarik Issad and Ralf Jockers -- Identification of interacting proteins using the yeast two-hybrid screen / Kelly L. Jordan-Sciutto and Marshall B. Montgomery -- Analysis of PDZ domain interactions using yeast two-hybrid and coimmunoprecipitation assays / Hyun Woo Lee, Jaewon Ko, and Eunjoon Kim -- Clustering assay for studying the interaction of membrane proteins with PDZ domain proteins / Jaewon Ko and Eunjoon Kim -- Mammalian cell microinjection assay to study the function of Rho family guanosine triphosphatases / Ritu Garg and Anne J. Ridley -- Affinity-based assay of Rho guanosine triphosphatase activation / Mary Stofega, Celine DerMardirossian, and Gary M. Bokoch -- Assay for phospholipase D in cell-free systems / Shankar S. Iyer and David J. Kusner -- Reconstitution system based on cytosol-depleted cells to study the regulation of phospholipase D / Amanda Fensome-Green and Shamshad Cockcroft -- Analysis of global gene expression profiles activated by chemoattractant receptors / Fernando O. Martinez and Massimo Locati -- Genetic reconstitution of bone marrow for the study of signal transduction ex vivo / Martha S. Jordan -- Proteomic analysis of human neutrophils / George Lominadze ... [et al.]. Transmembrane signaling by G protein-coupled receptors / Louis M. Luttrell -- Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases / Kanchana Nataranjan and Bradford C. Berk -- Protein-protein interactions in signaling cascades / Bruce J. Mayer -- Biological role of the CXCR4-SDF-1 axis in normal human hematopoietic cells / Marcin Majka and Mariusz Z. Ratajczak -- Functional expression of CXCR4 in Saccharomyces cerevisiae in the development of powerful tools for the pharmacological characterization of CXCR4 / Zi-xuan Wang, James R. Broach, and Stephen C. Peiper -- Characterization of constitutively active mutants of G protein-coupled receptors / Jean-Marc Navenot, Zi-xuan Wang, and Stephen C. Peiper -- G protein-coupled receptor dimerization and signaling / Mario Mellado ... [et al.] -- Real-time analysis of G protein-coupled receptor signaling in live cells / Venkatakrishna R. Jala and Bodduluri Haribabu -- Isolation of membrane rafts and signaling complexes / Kathleen Boesze-Battaglia -- Methods for the study of signaling molecules in membrane lipid rafts and caveolae / Rennolds S. Ostrom and Paul A. Insel --
  • 2009 Springer
    Homma, Ikuo; Katō, Nobumasa; Shioda, S.
  • 2011 Thieme eNeurosurgery
    Stamm, Aldo Cassol.
    "The diagnosis and treatment of the diseases of the skull base have changed dramatically in the past few years, transforming the fields of neurosurgery and otolaryngology-head and neck surgery. The increasing advances in these fields have addressed the ENT physicians and neurosurgeons to keep up with the expanding information in the exciting area of skull base. By publishing this book, we are presenting a multidisciplinary approach to the lesions of the skull base. We bring chapters written by the most experienced groups around the world with both, basic information and the latest advances in macro and surgical anatomy, radiology, anesthesia, endocrinology, and all modalities of transnasal endoscopic assisted surgical approaches to the anterior, middle, posterior, zygomatic and infra temporal fossae. In addition, the extended approaches such as to the craniocervical junction and petrous apex are also addressed. Especial emphasis is also given to the reconstruction techniques"--Provided by publisher.
  • 2013 Springer
    Galesic, Mirta; García Retamero, Rocío.
    Recent research in health decision making has shown that many patients, even those with a college education, have difficulties grasping a host of numerical concepts, including percentages and probabilities. Yet, basic numeracy and graph literacy are essential for understanding information relevant to making decisions about health, such as the incidence and prevalence of different diseases, risk reductions from medical screenings and treatments, and risk increases from side effects of treatments and unhealthy behaviors. Patients who have problems understanding such numerical concepts are often prone to errors in risk perception and medical choices. Importantly, informed medical decision making, heavily reinforced these days by the legal requirement for informed consent, depends critically on communication of quantitative medical information. Meeting the challenge of effectively communicating medical information to patients with different levels of numeracy and graph literacy has become more important than ever. Transparent Communication of Health Risks describes a series of cross-cultural studies investigating how people in countries with different medical and educational systems understand numerical and graphical information, what they know about existing medical treatments and screenings, which presentation formats help them better understand the relevant information, and how they use the data to make medical decisions. Focusing on the careful measurement of necessary knowledge and skills, the book also includes validated numeracy and graph literacy scales in English, Spanish, and German. Some of the topics covered in the book are:numeracy and graph literacy for health;measuring risk comprehension in educated samples;communicating information about medical treatment and screening;reducing the effect of framed messages about health;the effect of individual differences on shared decision making; andtransparent health information in the media.Transparent Communication of Health Risks emphasizes the importance and value of working toward the development of tailored risk communication interventions and clarifies the tasks ahead for health psychologists, public health professionals, pharmaceutical and medical education companies, medical physicists, and nurses.
  • 2014
    Sharp, Lesley Alexandra.
    PrintStatus: Not Checked OutLane Catalog Record
    " In The Transplant Imaginary, author Lesley Sharp explores the extraordinarily surgically successful realm of organ transplantation, which is plagued worldwide by the scarcity of donated human parts, a quandary that generates ongoing debates over the marketing of organs as patients die waiting for replacements. These widespread anxieties within and beyond medicine over organ scarcity inspire seemingly futuristic trajectories in other fields. Especially prominent, longstanding, and promising domains include xenotransplantation, or efforts to cull fleshy organs from animals for human use, and bioengineering, a field peopled with "tinkerers" intent on designing implantable mechanical devices, where the heart is of special interest. Scarcity, suffering, and sacrifice are pervasive and, seemingly, inescapable themes that frame the transplant imaginary. Xenotransplant experts and bioengineers at work in labs in five Anglophone countries share a marked determination to eliminate scarcity and human suffering, certain that their efforts might one day altogether eliminate any need for parts of human origin. A premise that drives Sharp's compelling ethnographic project is that high-stakes experimentation inspires moral thinking, informing scientists' determination to redirect the surgical trajectory of transplantation and, ultimately, alter the integrity of the human form. "-- Provided by publisher.
  • 2012 Karger
    Häusermann, Peter; Passweg, Jakob; Steiger, Jürg.
  • 2014 ClinicalKey
    Forsythe, John L. R.
    Controversies in the ethics of organ transplantation / Marc J. Clancy and Alex T. Vesey -- Organ donation in the UK : recent progress and future challenges / Christopher J. Rudge -- Immunology of graft rejection / George Tse and Lorna Marson -- Testing for histocompatibility / Phil Dyer, Ann-Margaret Little and David Turner -- Immunosuppression with the kidney as paradigm / David Wojciechowski, Gregory Veillette and Flavio Vincenti -- Preservation and perfusion of abdominal organs for transplantation / John O'Callaghan, Peter Friend and Rutger J. Ploeg -- Recent trends in kidney transplantation / Gabriel C. Oniscu -- Liver transplantation / James J. Pomposelli, Mary Ann Simpson, Caroline Simon and Elizabeth A. Pomfret -- Pancreas transplantation / Murat Akyol -- Islet transplantation / John J. Casey -- Cardiothoracic transplantation / Asif Hasan and John H. Dark -- Transplant infectious disease / Camille Nelson Kotton -- Chronic transplant dysfunction / Shikha Mehta and Roslyn B. Mannon.
  • 2013 Springer Protocols
    Leffell, Mary S.; Zachary, Andrea A.
    Alloreactivity / Sidonia B.G. Eckle, Jamie Rossjohn, and James McCluskey -- Antibodies in Transplantation : The Effects of HLA and Non- HLA Antibody Binding and Mechanisms of Injury / Nicole M. Valenzuela and Elaine F. Reed -- Cell Mediated Rejection / Kathryn J. Wood, Masaaki Zaitsu, and Ryoichi Goto -- Transplantation Tolerance / Colin Brinkman ... [et al.] -- Composite Tissue Transplantation / Gerald Brandacher -- Transplantation of the Sensitized Patient: Histocompatibility Testing / Robert A. Montgomery, Mary S. Leffell, and Andrea A. Zachary -- Thoracic Organ Transplantation : Laboratory Methods / Jignesh K. Patel and Jon A. Kobashigawa -- HLA Typing by Sequence-Specific Primers / Mike Bunce and Ben Passey -- Human Leukocyte Antigen (HLA) Typing by DNA Sequencing / Ana Lazaro ... [et al.] -- Next-Generation HLA Sequencing Using the 454 GS FLX System / Elizabeth A. Trachtenberg and Cherie L. Holcomb -- Chimerism Testing by Quantitative PCR Using Indel Markers / Ketevan Gendzekhadze, Laima Gaidulis, and David Senitzer -- Gene-Specific PCR Typing of Killer Cell Immunoglobulin- Like Receptors / Raja Rajalingam and Elham Ashouri -- Complement-Dependent Cytotoxicity Crossmatch / Jeremy Ryan Pena, Donna Fitzpatrick, and Susan L. Saidman -- Lymphocyte Crossmatching by Flow Cytometry / Robert A. Bray -- Solid Phase Assay Measuring C4d Deposition to Determine Complement Fixation by HLA-Specific Antibodies / John D. Smith and Marlene L. Rose -- C1q Assay for the Detection of Complement Fixing Antibody to HLA Antigens / Ge Chen and Dolly B. Tyan -- Tetramer Staining for the Detection of HLA-Specific B cells / Donna P. Lucas, Mary S. Leffell, and Andrea A. Zachary -- Flow Cytometric Crossmatch Test Using Endothelial Precursor Cells Isolated from Peripheral Blood / Annette M. Jackson, Donna P. Lucas, and Jessica L. Badders -- Detection of Antibodies to the Angiotensin II-Type 1 Receptor in Transplantation / Duska Dragun -- Detection of Antibodies to Self-Antigens (K-alpha 1 Tubulin, Collagen I, II, IV, and V, Myosin, and Vimentin) by Enzyme-Linked Immunosorbent Assay (ELISA) / Nayan J. Sarma, Venkataswarup Tiriveedhi, and T. Mohanakumar -- Cylex ImmuKnow Cell Function Assay / Adriana Zeevi and John Lunz -- Detection of Intracellular Cytokines / Nancy L. Reinsmoen and Chih-Hung Lai -- Tolerogenic Dendritic Cells and Induction of T Suppressor Cells in Transplant Recipients / George Vlad and Nicole Suciu-Foca -- Discovery and Customized Validation of Antibody Targets by Protein Arrays and Indirect ELISA / Tara K. Sigdel and Minnie M. Sarwal -- RNA Purification and Expression Analysis Using Microarrays and RNA Deep Sequencing / Steven R. Head ... [et al.].
  • 2006 Springer Protocols
    Hornick, Philip; Rose, Marlene L.
    Current status of renal transplantation / Christopher J. Callaghan and J. Andrew Bradley -- Current status of liver transplantation / Peter J. Friend and Charles J. Imber -- Current status of islet transplantation / Jonathan R.T. Lakey, Mohammadreza Mirbolooki, and A.M. James Shapiro -- Current status of lung transplantation / Allan R. Glanville -- Chronic rejection in the heart / Philip Hornick and Marlene Rose -- Direct and indirect allorecognition / Philip Hornick -- HLA typing and its influence on organ transplantation / Stephen Sheldon and Kay Poulton -- Strategies for gene transfer to solid organs: viral vectors / Charlotte Lawson -- Nonviral vectors / Louise Collins -- Detection and clinical relevance of antibodies after transplantation / John D. Smith and Marlene Rose -- Reprogramming the immune system using antibodies / Luis Graca and Hermann Waldmann -- In vitro assays for immune monitoring in transplantation / Maria P. Hernandez-Fuentes and Alan Salama -- Proteomics and laser microdissection / Emma McGregor and Ayesha DeSouza -- Real-time quantitative polymerase chain reaction in cardiac transplant research / Leanne E. Felkin, Anne B. Taegtmeyer, and Paul J.R. Barton -- Organ preservation / Mark Hicks ... [et al.] -- Pharmacological manipulation of the rejection response / Peter Mark Anthony Hopkins -- Experimental models of graft arteriosclerosis / Bezhad Soleimani and Victor C. Shi.
  • 2008 Springer
    Gordon, Chad R.; Hewitt, Charles W.; Lee, W. P. Andrew.
    The establishment of composite tissue allotransplantation as a clinical reality / Joseph E. Murray -- The evolution of composite tissue allotransplantation: the twentieth century realization of "Cosmas and Damian" / Chad R. Gordon ... [et al.] -- The impact of the discovery of cyclosporine on transplantation of composite tissue allografts / Zsolt T. Csapo, Bence Forgacs, and Barry D. Kahan -- The first limb transplants with cyclosporine / Christopher J. Salgado, Samir Mardini, and Charles W. Hewitt -- Translational research in composite tissue allotransplantation / Linda C. Cendales, David E. Kleiner, and Allan D. Kirk -- Relative antigenicity of allograft components and differential rejection / Jignesh Unadkat ... [et al.] -- On the road to tolerance induction in composite tissue allotransplantation / Mark A. Hardy -- Donor-specific tolerance / Au H. Bui, Gerald Lipshutz, and Jerzy Kupiec-Weglinski -- Immune tolerance induction: basic concepts for composite tissue allotransplantation / Patricio Andrades, Clement Asideu, and Judith M. Thomas -- Allograft survival with calcineurin inhibitors / Neil F. Jones and Esther Voegelin -- Long-term prevention of rejection and combination drug therapy / Thomas H. Tung -- Locoregional immunosuppression in composite tissue allografting / Scott A. Gruber -- New approaches to antibody therapy / Dalibor Vasilic, Moshe Kon, and Cedric G. Francois -- World experience of hand transplantation-independent assessment / W.P. Andrew Lee, Justin M. Sacks, and Elaine K. Horibe -- Hand transplantation: Lyon experience / Palmina Petruzzo ... [et al.] -- Hand transplantation: the Louisville experience / Vijay S. Gorantla and Warren C. Breidenbach III -- Hand transplantation: the Innsbruck experience / Stefan Schneeberger, Marina Ninkovic, and Raimund Margreiter -- Vascularized bone marrow transplantation / Chau Y. Tai ... [et al.] -- Vascularized bone marrow transplantation: pathology of composite tissue transplantation-induced graft-versus-host-disease / Rajen Ramsamooj and Charles W. Hewitt -- Immune cell redistribution after vascularized bone marrow transplantation / Waldemar L. Olszewski and Marek Durlik -- Vascularized knee transplantation / Michael Diefenbeck and Gunther O. Hofmann -- Tracheal transplantation / Gabriel M. Marta and Walter Klepetko -- Laryngeal transplantation / Robert R. Lorenz and Marshall Strome -- Face transplantation / Maria Siemionow and Galip Agaoglu -- The role of allografts in lower extremity reconstruction / Milton B. Armstrong, Ricardo Jimenez-Lee, and Eddie Manning -- Skin allografts in scalp reconstruction / Peter C. Neligan -- Abdominal wall transplantation / Chau Y. Tai and Susan E. Mackinnon -- Live-donor nerve transplantation / Scott A. Gruber and Pedro Mancias -- Ethical and policy concerns of hand/face transplantation / Rhonda Gay Hartman -- Ethical debate on human face transplantation / François Petit -- Psychosocial issues in composite tissue allotransplantation / Barckley Storey ... [et al.] -- Composite tissue transplantation in the twenty-first century / Kirby S. Black and Charles W. Hewitt.
  • 2006 Springer
    Nógrádi, Antal.
    Anatomy and physiology of the spinal cord / Antal Nógrádi and Gerta Vrbová -- Recovery of function after spinal cord injury / Gavin Clowry and Urszula Slawinska -- Recovery of lost spinal cord function by facilitating the spinal cord circuits below the lesion / Urszula Slawinska -- Encouraging regeneration of host neurones: the use of peripheral nerve bridges, glial cells or biomaterials / Antal Nógrádi -- Encouraging regeneration of host neurons: transplantation of neural tissues into the injured spinal cord grafts of embryonic neural tissue / Gerta Vrbová -- Replacement of specific neuronal populations in the spinal cord / Antal Nógrádi -- Replacement of specific populations of cells: glial cell transplantation into the spinal cord / Antal Nógrádi.
  • 2015 ClinicalKey
    Busuttil, Ronald W.; Busuttil, Ronald W.; Klintmalm, Goran B.
    Drs. Busuttil and Klintmalm present Transplantation of the Liver, 3rd Edition, which has been thoroughly revised to offer you the latest protocols, surgical approaches, and techniques used in this challenging procedure. Encompassing today's expert knowledge in the field, this medical reference book is an ideal single source for authoritative, up-to-date guidance on every imaginable aspect of liver transplantation. Understand today's full range of transplantation techniques with complete step-by-step descriptions of each, and access the background information and management options for each hepatic disease entity. Take advantage of detailed discussions of everything from pathophysiology and patient and donor selection, to transplantation anesthesia and operative procedures; immunosuppression; postoperative care; and ethical issues.
  • 2013 ScienceDirect
    Becker, Sid M.; Kuznetsov, Andrey V.
    Transport in Biological Media is a solid resource of mathematical models for researchers across a broad range of scientific and engineering problems such as the effects of drug delivery, chemotherapy, or insulin intake to interpret transport experiments in areas of cutting edge biological research. A wide range of emerging theoretical and experimental mathematical methodologies are offered by biological topic to appeal to individual researchers to assist them in solving problems in their specific area of research. Researchers in biology, biophysics, biomathematics, chemistry, engineers and clinical fields specific to transport modeling will find this resource indispensible. Provides detailed mathematical model development to interpret experiments and provides current modeling practices Provides a wide range of biological and clinical applicationsIncludes physiological descriptions of models.
  • 2013 Springer
    Steffansen, Bente; Sugiyama, Yūichi.
    Transporters in Drug Development is a corner stone in a high profile book series on advances in pharmaceutical sciences initiated by AAPS, Springer and Professor Daan Crommelin as series Editor. Transporters in Drug Development: Discovery, Optimization, Clinical Study and Regulation list chapters written by leading researchers in the transporter field from academia, pharmaceutical industry and medicines agencies. The book encompasses examples and advises on how membrane transporters can be dealt with in academic industrial drug discovery and pharmaceutical development as well as from a regulatory perspective. Methods and examples of in vitro characterization of single transporters in intestine, liver and kidney are described as well as characterization of substrate overlap between various transporters. Furthermore, probes and biomarkers are suggested for studies of the transporters impact on the pharmacokinetics of drug substrates/candidates interacting on transporters. The challenges of translating in vitro observed interaction of transporters into in vivo relevance are discussed as well as the perspectives of applying targeted proteomics and mechanistic modelling in this process.
  • 2009 Springer
    Lankenau, Dirk-Henner; Volff, Jean-Nicolas.
  • 2010 ClinicalKey
    Lanzino, Giuseppe; Laws, Edward R.
    Transsphenoidal Surgery, by Drs. Laws and Lanzino, captures all of today's clinical knowledge on the multidisciplinary management of pituitary tumors, with a focus on surgical techniques. Acclaimed international experts bring you detailed guidance on natural history, radiologic and clinical aspects, surgical indications, and resection techniques. What₂s more, case presentations and clinical photographs help you reduce the risk of error and advance your own surgical skills. At expertconsult.com, you'll have online access to the full text plus streaming videos of key procedures to help you provide the best possible outcomes for every patient. Access the fully searchable text online at expertconsult.com and view hours of videos in which experts demonstrate how to perform key procedures. Refine your skills through discissions of intraoperative imaging, new techniques in transsphenoidal surgery, new microsurgical procedures, radiosurgical techniques, and more. Get balanced and comprehensive perspectives on pituitary surgery from well-recognized international, multidisciplinary contributors. Make better-informed decisions with case presentations, drawn from Dr. Laws's 40 plus years as a leader in pituitary surgery, that include a summary of the clinical history, preoperative radiographs, and postoperative clinical information and radiographs. Tap into exceptional visual guidance and reduce the risk of error through abundant clinical photographs, line drawings, and procedural videos. Find the information you need quickly via a consistent chapter-to-chapter organization.
  • 2010
    Sun, Lynn Wanshu; Buckmaster, Paul S.; Luo, Liqun; Sapolsky, Robert M.; Schnitzer, Mark Jacob.
    The eyeblink is one of the most basic motor behaviors and has served as a longstanding model for the study of adaptive and associative forms of motor conditioning. However, cerebellar pathways that support blinking behaviors remain poorly studied in the mouse, an increasingly popular animal model for motor learning. The precise location of eyeblink-related neurons is poorly defined, particularly in the red nucleus and the cerebellar nuclei and cortex. To pinpoint these neurons, I injected the GFP-expressing retrograde transsynaptic viral tracer Pseudorabies (PRV-152) into the orbicularis oculi muscle in the eyelids of live C57Bl6 mice. PRV travels retrograde across multiple synapses in the motor pathway and infects cells ultimately projecting to the injection site. By registering anatomical sites of the virally labeled cells, I created detailed maps of neurons presumably involved in controlling blink-related behavior. In the facial nucleus, viral labeling was strictly ipsilateral to the injection site and restricted to the dorsolateral rostral segment. The red nucleus is bilaterally labeled at the lateral rim with heavier labeling in the contralateral nucleus. Labeling was bilaterally distributed across all three deep cerebellar nuclei. In the cerebellar cortex, a characteristic spatiotemporal pattern was observed. Posterior vermal and floccular Purkinje cells were labeled first, followed by mid- and anterior vermal cells, and finally cells in the hemispheric Crus 1/2 and Simple lobules. Based on these results, I hypothesized that PRV injections into the eyelid uncover multiple distinct, cerebellar-modulated motor output pathways. These pathways have not previously been explored in the mouse; additionally, several of the putative pathways were poorly defined in other model systems as well. This hypothesis was then tested with single-step retrograde tracings from each of the deep cerebellar nuclei. The following circuits were confirmed: 1) from the ansiform lobule to the dentate nucleus 2) from the simple lobule to the anterior interpositus nucleus 3) from the anterior vermal and paravermal cerebellar cortex to the posterior interpositus nucleus, and 4) from the posterior vermis and paravermis to the fastigial nucleus. In prior literature, pathways 1 and 2 have been implicated in classical conditioning, and pathway 3 in cerebellar modulation of reflex blinks. Based on circuit analysis, pathway 4 is putatively associated with eye-eyelid coordination, but there is little existing research on this possibility. To complete my investigation of the mouse cerebellar eyeblink circuit, I traced anterograde from the vestibular nucleus to the red nucleus and retrograde from the red nucleus to the vestibular nucleus, establishing the existence of a previously unexplored vestibulorubral pathway in the mouse which may serve as the output circuit of pathway 4. As a whole, this body of work explores the location and distribution of eyeblink-related neurons in the mouse, identifies multiple parallel motor circuits in the mouse cerebellum, and offers evidence toward functional organization of the cerebellum.
  • 2011 Springer
    Bongiorni, Maria Grazia; Wilkoff, Bruce L.
  • v. 1, 1940.
    Cea, Leopoldo,.
    PrintStatus: Not Checked OutLane Catalog Record
    1. Análisis de la sangre.

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