Books

Summary: Hand eczema is a major complaint worldwide and a frequent occupational disorder. This book provides a comprehensive and detailed overview of the classification, etiology, diagnosis, prevention, and therapy of hand eczema. It is innovative, up to date, and practical. The links with particular occupations are explained, the various diagnostic tests are presented, and the role of different topical and systemic treatments is clearly described. The authors are world leaders in the field. The Textbook of Hand Eczema reflects a new era in hand dermatitis and will be invaluable for all who deal with the condition in their clinical practice.

Contents:
Sinonasal Tract
Anatomy and Histology
Sinonasal Tract, Nonneoplastic
Sinonasal Tract, Benign
Sinonasal Malignancies
Nasopharynx and skull base.

Contents:
Biology of hernia formation
Epidemiology/Importance of hernia research
Evaluating evidence and outcomes in Hernia repair
Inguinal hernia
Epidemiology of inguinal hernia
Diagnostic options for inguinal hernia repair
Watchful waiting in inguinal hernia repair
Mesh options for inguinal hernia repair
Anesthetic considerations for inguinal hernia repair
Overview of hernia techniques
Shouldice technique
Tissue based repairs
Lichtenstein repair
Open posterior approaches
Laparoscopic repair (TEP)
Laparoscopic repair (TAPP)
Emerging technology: Robotic inguinal hernia repair
Emerging technology: SILS inguinal hernia repair
Overview of chronic groin pain
Preventive strategies for chronic groin pain
Diagnostic evaluations for chronic groin pain
Pain mapping for chronic groin pain
Non-surgical options for management of chronic groin pain
Surgical options for management of chronic groin pain
Emergency and Atypical Hernias: Management of Incarcerated/Strangulated inguinal Hernias
Emergency and Atypical Hernias: Management of Femoral/Obturator hernias
Incisional and ventral hernias
Introduction/Epidemiology
Hernia prevention/Techniques for laparotomy closure
The use of prophylactic mesh in laparotomy closure and ostomy creation
Preoperative prepration/Enhanced recovery protocols for incisional/ventral hernias
Mesh options for incisional/ventral hernias
Overview of Techniques in incisional and ventral hernias
Laparoscopic approaches to incisional/ventral hernias
Open approaches: Onlay techniques
Open approaches: Retrorectus/TAR techniques
Open approaches: Anterior component separation techniques
Open approaches: Minimally invasive techniques for component separation
Open approaches: Alternative methods for component separation
Emerging technology: Robotic IPOM
Emerging technology: Robotic retromuscular repair
Emerging technology: SILS lap VHR
Controversies in incisional/ventral hernia: Laparoscopic closure of hernia defects
Controversies in incisional/ventral hernia: Mesh choices in contaminated cases
Umbilical hernia repair
Complex and atypical incisional/ventral hernia: Management of incarcerated/strangulated hernias
Complex and atypical incisional/ventral hernia: Aytpical henrias: Subxiphoid/Suprapubic/Lumbar/Flank hernias
Complex and atypical incisional/ventral hernia: Management of diastasis Recti
Complex and atypical incisional/ventral hernia: Management Dehiscence/Evisciration
Complex and atypical incisional/ventral hernia: Abdominal compartment syndrome and management of the open abdomen
Complex and atypical incisional/ventral hernia: Parastomal hernia repair
Complex and atypical incisional/ventral hernia: Management of mesh infections and enterocutaneous fistulas
Complex and atypical incisional/ventral hernia: Use of preoperative progressive pneumoperitoneum in complex abdominal wall hernias
Complex and atypical incisional/ventral hernia: The use of Botox for chemical component separation
Athletic pubalgia
Overview of problem/epidemiology
Diagnostic evaluations
Non-surgical treatment options in Athletic pubalgia
Surgical treatment options in Athletic pubalgia.

Summary: "When it was originally published in 2009, the Textbook of Hospital Psychiatry was the first comprehensive guide to hit the market in more than a decade. This updated edition includes new material in each of the 30 chapters, with a focus on treatment, staffing, and quality of care changes, and includes new, forward-looking chapters on consumer and family perspectives, collaborative care, measurement-based care, safety, and more. Providers and policymakers agree that integrating behavioral treatments into regular courses of patient care helps address post-discharge needs, including safe housing, reliable transportation, and nutrition. Behavioral wellness is currently benefitting from increased public attention, but disparities in access continue. There is a significant need for dedicated psychiatric hospitals and dedicated units in general hospitals to meet America's mental health needs. Progress is happening, but many familiar challenges remain. Inadequate healthcare coverage and reimbursement for services has left both patients and medical providers desperate for reform. Staffing shortages are worsening as practitioners in the baby boomer generation retire and those roles go unfilled by new graduates. Despite these challenges, psychiatric hospitals continue to evolve and discover new solutions to provide transformative care for patients. This updated textbook contains valuable knowledge and novel insights for clinicians regarding treatment, staffing, and care, and features new chapters on family involvement and safety, federal and local financing, and information on collaborative care and LEAN. Forward-looking chapters focus on the integration of treatment across settings and providers and examine new strategies such as telemedicine to extend the reach of clinicians. Together, and with expert guidance, readers of this must-have resource will find a roadmap for clinical, administrative, and financial steps to help providers take advantage of these unprecedented times to develop services and advance hospital psychiatry in the United States"-- Provided by publisher.

Summary: This comprehensive volume captures the latest scientific evidence, technological advances, treatments and impact of biotechnology in hyperbaric oxygen therapy. Divided into three distinct sections, the book begins with basic aspects that include history, equipment, safety and diagnostic approaches; this is followed by clinical applications for hyperbaric oxygen therapy in various modalities; the last section provides an overview of hyperbaric medicine as a specialty with best practices from around the world. Integration of multidisciplinary approaches to complex disorders are also covered. Updated and significantly expanded from previous editions, Textbook of Hyperbaric Medicine, 6th Edition will continue to be the definitive guide to this burgeoning field for students, trainees, physicians and specialists. .

Contents:
Part I. Basic Aspects
Chapter 1. The History of Hyperbaric Medicine
Chapter 2. Physical, Physiological, and Biochemical Aspects of Hyperbaric Oxygenation
Chapter 3. Effects of Diving and High Pressure on the Human Body
Chapter 4. Physical Exercise under Hyperbaric Conditions
Chapter 5. Hypoxia
Chapter 6. Oxygen Toxicity
Chapter 7. Hyperbaric Chambers: Equipment, Technique, and Safety
Chapter 8. Indications, Contraindications, and Complications of HBO Therapy
Chapter 9. Drug Interactions with Hyperbaric Oxygenation
Chapter 10. Neurophysiologic SPECT Brain Function Imaging and Hyperbaric Oxygen Therapy
Part II. Clinical Applications
Chapter 11. Decompression Sickness
Chapter 12. Cerebral Air Embolism
Chapter 13. Carbon Monoxide and Other Tissue Poisons
Chapter 14. HBO Therapy in Infections
Chapter 15. Hyperbaric Oxygen Therapy and Chronic Lyme Disease: The Controversy and the Evidence
Chapter 16. HBO Therapy in Wound Healing, Plastic Surgery, and Dermatology
Chapter 17. HBO Therapy in the Management of Radionecrosis
Chapter 18. The Use of HBO in Treating Neurological Disorders
Chapter 19. Role of Hyperbaric Oxygenation in the Management of Stroke
Chapter 20. HBO Therapy in Global Cerebral Ischemia/Anoxia and Coma
Chapter 21. HBO Therapy in Neurosurgery
Chapter 22. Oxygen Treatment for Multiple Sclerosis Patients
Chapter 23. HBO in the Management of Cerebral Palsy
Chapter 24. HBO Therapy in Miscellaneous Neurological Disorders
Chapter 25. HBO Therapy in Cardiovascular Diseases
Chapter 26. HBO Therapy in Hematology and Immunology
Chapter 27. HBO Therapy in Gastroenterology
Chapter 28. HBO and Endocrinology
Chapter 29. HBO and Pulmonary Disorders
Chapter 30. Hyperbaric Oxygenation in Traumatology and Orthopedics
Chapter 31. HBO Therapy in Otolaryngology
Chapter 32. HBO Therapy and Ophthalmology
Chapter 33.Hyperbaric Oxygenation in Obstetrics and Gynecology
Chapter 34. Use of Hyperbaric Oxygenation (HBO2) in Neonatal Patients
Chapter 35. Hyperbaric Oxygenation in Geriatrics
Chapter 36. HBO as an Adjuvant in Rehabilitation and Sports Medicine
Chapter 37. Nursing and Hyperbaric Medicine
Chapter 38. Role of HBO in Enhancing Cancer Radiosensitivity
Chapter 39. HBO Therapy and Organ Transplants
Chapter 40. Hyperbaric Oxygen Pretreatment and Preconditioning
Chapter 41. Anesthesia in the Hyperbaric Environment
Chapter 42. Hyperbaric Oxygen in Resuscitation
Chapter 43. HBO in Military Medicine
Part III. Hyperbaric Medicine as a Specialty
Chapter 44. Training and Practice of Hyperbaric Medicine
Chapter 45. Research in Hyperbaric Medicine
Chapter 46. Personalized Hyperbaric Medicine
Chapter 47. The Future of Hyperbaric Medicine
Chapter 48. Ethical Issues, Standards, and Quality Control in the Practice of Hyperbaric Medicine
Chapter 49. Hyperbaric Medicine in Europe
Chapter 50. Hyperbaric Medicine in the United States
Chapter 51. Hyperbaric Medicine in Latin America.

Summary: Liver transplantations require a complex and varied, multidisciplinary approach involving not only hepatologists and surgeons but also pathologists, psychologists, professional educators, nurses and, in the case of young patients, also pediatricians and development experts. This textbook provides an overview of the management problems involved in liver transplantation for acute and chronic liver disease, pediatric liver transplantation and the psychosocial aspects of liver transplantation. A closing chapter, focusing on the developments and future prospects in liver transplantation, outlines the potential offered by donors after cardiac death, cell therapies and organogenesis. The multidisciplinary approach is also maintained in the selection of authors, all experts actively engaged in the various disciplines involved in liver transplantations. This aspect, together with its precise and didactic descriptions of all phases of liver transplantation for chronic and acute diseases from managing waiting lists to post-transplant complications make the book a valuable tool for fellows, trainees, and specialists in the field seeking accurate framework for liver transplantation in its many facets.

Contents:
Part 1. Liver transplantation for chronic liver diseases: Epidemiology of chronic liver diseases. Indications to liver transplantation (chronic liver diseases, tumours, genetic disorders, ACLF). Referral to the liver transplant center . Evaluation of the recipient. Management of the patient on the waiting list, scoring systems and priority. Organ allocation systems in Europe, U.S. and Asia. Surgical aspects of liver transplantation. Living-related liver transplantation. Critical care of the liver transplant recipient. Surgical complications after liver transplantation (vascular, biliary). Rejection and immunosuppressive regimens. Role of histopathology. Infections in the liver transplant recipient. Metabolic complications after liver transplantation. Renal dysfunction after liver transplantation. Recurrence of the primary liver disease (HBV, HCV, Alcohol, Cholestatic/Autoimmune diseases). De novo tumours after liver transplantation. Graft and patient survival
Part 2. Liver transplantation for acute liver failure: Epidemiology of acute liver failure. Prognostic scores and timing to liver transplantation. Pre-transplant management. Outcomes after liver transplantation, graft and patient survival
Part 3. Paediatric liver transplantation: Epidemiology of paediatric liver diseases. Indications to liver transplantation. Outcomes after liver transplantation in the paediatric population. Part 4. Psycho-social aspects of liver transplantation. Psychiatric and psychological evaluation of the potential liver transplant candidate. Fertility, sexual function and pregnancy after liver transplantation. Adherence and quality of life. Transition to adult care. The role of transplant coordinator, nurse and professional educator
Part 5. Developments and future prospective in liver transplantation: Donor after cardiac death. Cell therapies and transplantation. Organogenesis. Tolerance in liver transplantation.

Summary: This textbook provides a guide to reconstructive surgery of genitourethral problems in male patients. The first section covers all aspects of urethral reconstruction, including the functional anatomy of the urethra, etiology, epidemiology, and demographic differences in urethral pathology. The second section focuses on surgical reconstruction of penile and scrotal anomalies and dysfunctions. Textbook of Male Genitourethral Reconstruction aims to aid the management of male genitourethral reconstruction patients by reviewing the recent advancements in technology and surgical technique. This book is relevant to urologists, plastic and reconstructive surgeons, medical students, and health care professionals working within urology and plastic surgery.

Contents:
N of Buried Penis
Complex Scrotal Repair and Testicular Prosthetics
Penile Enlargement Surgery: Fact or Fiction?
Penile Self-Injections for Girth Augmentation: Treatment of Complications
Penile Transplantation
The Last Frontier in Penile Reconstruction
PART III: Urinary Incontinence and Neurourology. Surgical Treatment of Male Stress Urinary Incontinence: An Overview
Treatment of Male Stress Urinary Incontinence: Advance Sling
Treatment of Male Stress Urinary Incontinence: Virtue Quadratic Sling
Treatment of Male Stress Urinary Incontinence: ATOMS System
Treatment of Male Stress Urinary Incontinence: Artificial Urinary Sphincter
Surgical Reconstruction of Lower Urinary Tract in the Adult Spinal Cord Injured Male
PART IV:Gender-Affirming Surgery. Urethral Reconstruction in Female-to-Male Gender-Affirming Surgery
Penile Reconstruction after Trauma and in Gender Dysphoria
Urological Complications of Gender-Affirming Surgery
Penile Prosthesis Implantation in Transgender Males nts
Surgical Reconstruction of Ischemic Necrosis of Bulbar Urethra
Use of Fasciocutaneous and Myocutaneous Flaps in Complex Urethral Reconstruction
Use of Bowel for Urethral Reconstruction
Perineal Urethrostomy: A Surgical Pearl in Failed Urethral Reconstruction
Urinary Diversion: The Last Resort in Urethral Reconstruction
Robot-Assisted Reconstruction of the Lower Urinary Tract
Impact of Urethral Reconstruction on Sexual Function
Tissue
Engineering in Urethral Reconstruction
The Role of Hyperbaric Oxygen Therapy in Urologic Reconstruction
PART II: Penile and Scrotal Reconstruction. Penile, Scrotal and Perineal Anatomy for the Reconstructive Surgeon
Modern Non-Surgical Strategies for Peyronies Disease
Modern Strategies for Plication in Peyronies Disease
Modern Strategies for Grafting in Peyronies Disease
Modern Strategies for Treatment of Peyronies Disease with Penile Prosthesis
Modern Strategies for the Surgical Treatment of Priapism
Surgical Treatment of Erectile Dysfunction: An Overview and Historical Perspective
Penile Prosthesis Implantation: Penoscrotal Approach
Penile Prosthesis Implantation: Infrapubic Approach
Penile Prosthesis Implantation in Complex, Previously Failed Settings
Prevention of Prosthetic Infection: Penile Implants and AUS
Non-infectious Penile Implant Complications and Avoidance
Dual Implantation of Inflatable Penile Prosthesis and Artificial Urinary Sphincter or Male Sling: Benefits and Risks
Vascular (Arterial and Venous) Surgery for Erection Dysfunction
Circumcision: Avoidance and Treatment of Complications
Microsurgery of Male Infertility
Surgical Reconstruction of Penile Fractures: Impact on Voiding and Sexual Function
Surgical Reconstruction of Penile and Scrotal Gunshot Injuries and Traumatic Avulsions in Civil and Military Conflicts
Organ-preserving Surgical Treatment of Penile Cancer and Glans Lichen Sclerosus
Surgical Reconstruction.

Summary: "The Textbook of Medical Psychiatry focuses on medical disorders that can directly cause or affect the clinical presentation and course of psychiatric disorders. Clinicians who work primarily in psychiatric settings, as well as those who practice in medical settings but who have patients with co-occurring medical and psychiatric illnesses or symptoms, can benefit from a careful consideration of the medical causes of psychiatric illnesses. The editors, authorities in the field, have taken great care both in selecting the book's contributors, who are content and clinical experts, and in structuring the book for maximum learning and usefulness. The first section presents a review of approaches to diagnosis, including medical, neurological, imaging, and laboratory examination and testing. The second section provides a tour of medical disorders that can cause psychiatric symptoms or disorders, organized by medical disease category. The third section adopts the same format as the second, offering a review of psychiatric disorders that can be caused or exacerbated by medical disorders, organized by psychiatric disorder types. The final section contains chapters on conditions that fall at the boundary between medicine and psychiatry. Even veteran clinicians may find it challenging to diagnose and treat patients who have co-occurring medical and psychiatric disorders or symptoms. The comprehensive knowledge base and clinical wisdom contained in the Textbook of Medical Psychiatry makes it the go-to resource for evaluating and managing these difficult cases"-- Provided by publisher.

Contents:
An Internist's Approach to the Neuropsychiatric Patient / Joseph Rencic, M.D., Deeb Salem, M.D.
The Neurological Examination for Neuropsychiatric Assessment / Sheldon Benjamin, M.D., Margo D. Lauterbach, M.D.
The Bedside Cognitive Examination in Medical Psychiatry / Sean P. Glass, M.D.
Neuroimaging, Electroencephalography, and Lumbar Puncture in Medical Psychiatry / Daniel Talmasov, M.D., Joshua P. Klein, M.D.
Toxicological Exposures and Nutritional Deficiencies in the Psychiatric Patient / Mira Zein, M.D., M.P.H., Sharmin Khan, M.D., Jaswinder Legha, M.D., M.P.H., Lloyd Wasserman, M.D.
Cardiovascular Disease / Peter A. Shapiro, M.D.
Endocrine Disorders and Their Psychiatric Manifestations / Jane P. Gagliardi M.D., M.H.S., FACP, DFAPA
Inflammatory Diseases and Their Psychiatric Manifestations / Rolando L. Gonzalez, M.D., Charles B. Nemeroff, M.D., Ph.D.
Infectious Diseases and Their Psychiatric Manifestations / Oliver Freudenreich, M.D., Kevin M. Donnelly-Boylen, M.D., Rajesh T. Gandhi, M.D.
Gastroenterological Disease in Patients With Psychiatric Disorders / Ash Nadkarni, M.D., David A. Silbersweig, M.D.
Renal Disease in Patients With Psychiatric Illness / Lily Chan, M.D., J. Michael Bostwick, M.D.
Neurological Conditions and Their Psychiatric Manifestations / Barry S. Fogel, M.D., Gaston C. Baslet, M.D., Laura T. Safar, M.D., Geoffrey S. Raynor, M.D., David A. Silbersweig, M.D.
Neurocognitive Disorders / Flannery Merideth, M.D., Ipsit V. Vahia, M.D., Dilip V. Jeste, M.D.
Neurodevelopmental Disorders / Aaron Hauptman, M.D., Sheldon Benjamin, M.D.
Cancer : Psychiatric Care of the Oncology Patient / Carlos G. Fernandez-Robles, M.D., Sean P. Glass, M.D.
Dermatology : Psychiatric Considerations in the Medical Setting. / Katherine Taylor, M.D., Janna Gordon-Elliott, M.D., Philip R. Muskin, M.D., M.A.
Obstetrics and Gynecology : Women's Mental Health and Reproductive Psychiatry / Marcela Almeida, M.D., Kara Brown, M.D., Leena Mittal, M.D., Margo Nathan, M.D., Hadine Joffe, M.D., M.Sc.
Mood Disorders Due to Medical Illnesses / Sivan Mauer, M.D., M.S.
John Querques, M.D., Paul Summergrad, M.D.,
Psychotic Disorders Due to Medical Illnesses / Hannah E. Brown, M.D., Shibani Mukerji, M.D., Ph.D., Oliver Freudenreich, M.D.
Anxiety and Related Disorders : Manifestations in the General Medical Setting / Charles Hebert, M.D., David Banayan, M.D., Fernando Espi-Forcen, M.D., Ph.D., Kathryn Perticone, A.P.N., Sameera Guttikonda, M.D., Mark Pollack, M.D.
Catatonia in the Medically Ill Patient / Scott R. Beach, M.D., Gregory L. Fricchione, M.D.
Substance Use Disorders in the Medical Setting / Samata R. Sharma, M.D., Saria El Haddad, M.D., Joji Suzuki, M.D.
Chronic Pain. / Robert M. McCarron, D.O., Samir J. Sheth, M.D., Charles De Mesa, D.O. M.P.H., Michelle Burke Parish, Ph.D., M.A.
Insomnia / Karl Doghramji, M.D.
Somatic Symptom and Related Disorders / Anna L. Dickerman, M.D., Philip R. Muskin, M.D., M.A.

Summary: This textbook addresses the growing need for a manual that teaches when and how to perform nasal tip rhinoplasty through an "Open-Approach". Practitioners will value the comprehensive coverage of the topic. The actual surgical steps involved in the various techniques form the main body of the work, while a wealth of intra-operative photographs facilitate the learning experience. The views expressed are solely those of the author, based on his personal experience. He makes no claims to the content being exhaustive or the only possible approach and has extensively referenced various experts in the field who have contributed to this topic. This book represents the author's view of how to approach nasal tip deformities, and how to arrive at an algorithm in putting together various surgical techniques in a "sequence" to achieve meaningful results. The book also explores the clinical correlation, which is just as or arguably even more important in nasal tip surgery. The main chapters will focus on the suture, grafting, non-suture and non-grafting techniques in nasal tip reconstruction. Drawing on the author's surgical experience, gathered in the course of over 1700 open tip surgeries over 23 years, the book fills a lacuna in teaching and training and will be of interest to all trainees and consultant surgeons seeking concise information on nasal tip surgery.

Contents:
CHAPTER 1
Introduction to Nasal Tip Rhinoplasty
CHAPTER 2
Surgical Anatomy of the Nasal Tip
CHAPTER 3
Aetiology, Pathology and Pathogenesis of Nasal Tip Deformities
CHAPTER 4
Assessment of the Nasal Tip
CHAPTER 5
Nasal Tip Rhinoplasty
Consultation Process
CHAPTER 6
Surgical Principles in Nasal Tip Rhinoplasty
CHAPTER 7
Open (External) Approach
Incision and flap elevation
CHAPTER 8
Suture techniques in Nasal Tip Rhinoplasty
CHAPTER 9
Grafting techniques in Nasal Tip Rhinoplasty
CHAPTER 10
Non suture and Non grafting techniques in Nasal Tip Rhinoplasty
CHAPTER 11
Management of Nasal Septum. A "Step-Ladder" approach
CHAPTER 12
Controlling the Nasal Dorsum
CHAPTER 13
Alar Base Surgery
CHAPTER 14
Cleft Lip Nasal Tip Rhinoplasty
CHAPTER 15
Closing the Skin Flap in Open Approach Nasal Tip Rhinoplasty
CHAPTER 16
Postoperative care and Complications after nasal tip rhinoplasty
CHAPTER 17- Nasal Valve Surgery - A "new" Concept
CHAPTER 18
Surgical Algorythms in Nasal Tip Rhinoplasty
CHAPTER 19 - Case Studies in Nasal Tip Rhinoplasty
CHAPTER 20
Ethics considerations in Rhinoplasty.

Summary: "Textbook of Nephro-Endocrinology, Second Edition, continues to be the definitive translational reference in the field of nephro-endocrinology, investigating both the endocrine functions of the kidneys and how the kidney acts as a target for hormones from other organ systems. It offers researchers and clinicians expert analyses of nephro-endocrine research and translation into the treatment of diseases such as anemia, chronic kidney disease (CKD), rickets, osteoporosis, and hypoparathyroidism. Changes to this edition include new chapters focused on hypercalcemia/hypocalcemia and the interaction of dialysis, chronic renal disease, and endocrine diseases. All chapters have been updated to include more preclinical data and more tables and schema that help translate this data into clinical recommendations. The section on hormones and renal insufficiency discusses insulin/diabetes, growth hormone, sex steroids, thyroid hormone, acid-base disturbances, and pregnancy"--Publisher's description.

Contents:
Physiology and regulation of the renin-angiotensin-aldosterone system
The renin-angiotensin-aldosterone system and the kidney
The renin-angiotensin system and the heart
Renin-angiotensin blockade : therapeutic agents
Vasopressin in the kidney--historical aspects
Molecular biology and gene regulation
Vasopressin antagonists in physiology and disease
Diabetes insipidus and syndrome of inappropriate antidiuretic hormone
The cardiac natriuretic peptide system : linking the heart and kidney in cardiorenal homeostasis and therapeutics
Aldosterone's mechanism of action : genomic and nongenomic signaling
Erythropoietin : an historical overview of physiology, molecular biology, and gene regulation
Erythropoiesis : the roles of erythropoietin and iron
Development of recombinant erythropoietin and erythropoietin analogs
Insulin resistance and the metabolic syndrome in chronic renal disease
Growth hormone
Sexual dysfunction in men and women with chronic kidney disease
Metabolic acidosis of chronic kidney disease
Pregnancy and the kidney
Vitamin D : molecular biology and gene regulation
Clinical syndromes of vitamin d and phosphate dysregulation
Molecular biology of renin and regulation of its gene
Vitamin d and the kidney : introduction and historical perspective
Extrahematopoietic actions of erythropoietin
Regulation of aldosterone production
Aldosterone and its cardiovascular effects
Aldosterone : history and introduction
Thyroid status in chronic renal failure patients
Aldosterone/mineralocorticoid receptors and their renal effects : molecular biology and gene regulation
The history of the renin-angiotensin system
Molecular biology of parathyroid hormone
Endocrine regulation of phosphate homeostasis.

Summary: This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This first volume focuses on neuroanesthesia. The book begins with basic information on neuroanesthesia, extensively discussing the anatomy of the brain and spine, physiology and relevant pharmacology. Special considerations for pregnant, pediatric and geriatric patients are covered in separate chapters. Each neurosurgical condition is discussed in a standard format relevant for neurosurgical patients, and each chapter, prepared by experts in the field, includes ample illustrations and flowcharts. Information is also provided on the latest evidence-based approaches, robotic surgery and gene therapy. The book offers a valuable resource for all residents, fellows and trainees in the fields of neuroanesthesia and anesthesia; it will also benefit practitioners and consultants. .

Contents:
Section I
Fundamentals of neuroanesthesia.- Section II
Pre-anesthetic evaluation.- Section III
Neuromonitoring.- Section IV
Anesthesia for neurosurgery.- Section V
Co-existing problems.- Section VI
Special considerations.- Section VII
Allied considerations.- Section VIII
Transfusion practice.- Section IX
Near misses.- Section X
Pain management.- Section XI
Special topics.

Summary: This two-volume book offers a comprehensive guide to anesthetic management and critical care management in neurosurgical and neurological patients. This second volume focuses on neurocritical care. The book begins with basic information on the principles of neurocritical care. Management of various neurological problems such as myasthenia gravis, Guillain-Barré syndrome, epilepsy, stroke and many more are discussed in detail. Subsequent sections address nursing care, physiotherapy and psychological care, issues related to brain death and organ donation, and common complications observed in neurological patients during their ICS stays. Each complication is discussed in detail, guiding readers in their clinical practice. In turn, the book's closing chapters cover e.g. the role of hypothermia and evidence-based practice. The book offers a valuable resource for all residents, fellows and trainees in the fields of neurointensive care and critical care; it will also benefit intensivists and neurocritical care experts. .

Contents:
Section I
Fundamentals of neurocritical care
Section II
Pharmacological considerations
Section III
Critical care management
Section IV
Neuromonitoring
Section V
Systemic care
Section VI
Supportive care
Section VII
Pain management
Section VIII
Ethical considerations
Section IX
Near misses in critical care
Section X
Recent advances.

Summary: Textbook of Neuromodulation encompasses the basic principles, methods and current clinical applications of invasive and non-invasive neuromodulation. Neurophysiological systems are reviewed along with the basic principles of neuroplasticity that constitutes the rationale for neuromodulation in human medicine. The overview of the neuromodulatory techniques is provided with special regard to safety and specific patient populations. Comprehensive and authored by leaders in the field, this resource presents the clinical potential, significance and practical applications of this innovative treatment approach.

Contents:
Principles of Neuromodulation
Methods and Technologies for Low-Intensity Transcranial Electrical Stimulation: Waveforms, Terminology, and Historical Notes
Peripheral Nerve Stimulation
Spinal Cord Stimulation
Dorsal Root Ganglion Stimulation: A Target for Neuromodulation Therapies
Deep Brain Stimulation
Motor Cortex Stimulation
Physiological Basis of Transcranial Magnetic Stimulation
Transcranial Direct Current Stimulation: Protocols and Physiological Mechanisms of Action
Customization of Transcranial Direct Current Stimulation for Susceptible Populations Including at the Extremes of Age, Obesity, and Stroke
Cranial Electrical Stimulation
The Mechanisms and Actions of Motor Imagery Within the Clinical Setting
Neuroprosthesis and Sensory-Motor Training
Clinical Applications of Neuromodulation in Psychiatry
Applications of Neuromodulation in Pain Management
Applications of Neuromodulation in Neurology and Neurorehabilitation
Neuromodulation for Addiction
Enhancement of Sensory and Cognitive Functions in Healthy Subjects
Conclusive Overview.

Summary: This textbook offers a concise, yet comprehensive account of human nutrition, food and nutrition-related health problems, based on the curricula of top universities around the globe. Nutrition is a multidisciplinary science, and as such, the book discusses various aspects of physiology, biochemistry, pathology, immunology, medicine, food science, and other fields related to nutrition, it focuses on the role of nutrition in the maintenance of health. The various chapters explore highly relevant issues, such as, addiction-related health problems, lifestyle-related disorders, social health problems and poor-maintenance of food hygiene and food safety. It also addresses the role of nutritional therapies for mental disorders, and includes an integrated perspective on cognition, oxidative stress and nutritional interventions in aging. Other topics include, the role of gut microbiota on human health, nutraceuticals as therapeutic agents and ketogenic diets. It also highlights malnutrition (protein energy malnutrition, starvation, malabsorption syndrome, eating disorders and overnutrition/obesity) and adipose tissue as an active endocrine organ. Moreover, it examines key concepts concerning the role of vitamins in the citric acid cycle (gluconeogenesis, ketogenesis, oxidative deamination and transamination) and precursors of coenzymes, as well as calorigenic hormones, appetite-stimulating/appetite-inhibiting hormones, anabolic and catabolic hormones affecting protein metabolism, and lipogenetic/lipolytic hormones.

Contents:
1. An Integrated View of Human Nutrition and Health
2. Macronutrients
3. Enzymes
4. Micronutrients
5. Dietary Fibers
6. Food Hypersensitivity
7. Food Groups, Balanced Diet and Food Composition
8. Nutritional Deficiencies and Disorders
9. Eating Disorders
10. Nutritional therapies, Exercise and Diet for Mental Disorders
11. Lifestyle-Related Diseases and Disorders
12. Addiction-Related Health Problems
13. Nutritional Management of Diseases
14. Miscellaneous Health Problems
15. An Integrated View of Cognition, Brain Functions, Oxidative Stress and Nutritional Interventions in Aging
16. Poor Maintenance of Food Hygiene and Food Safety
17. Potable Water. .

Summary: Arranged by ocular anatomy and subspecialty, with a detailed index permitting the reader to locate a discussion involving a specific type of ocular injury, this text covers ocular trauma in the pediatric and adult patient with medical and surgical treatment options, as well as potential complications. The Textbook of Ocular Trauma: Evaluation and Treatment provides a practical reference and educational resource for ophthalmologists, ophthalmology residents, emergency room physicians and residents, and pediatric physicians and residents, with basic and advanced instruction in the evaluation and management of eye and surrounding tissue trauma. This text includes multiple case reports with high quality color photographs after each section, as well as detailed medical illustrations of trauma cases and their treatment. Case studies include both common and unusual types of ocular and surrounding tissue trauma, which provide practical guidance in the evaluation and treatment of eye injuries.

Contents:
Chapter 1. The Ocular Trauma Patient Encounter
Chapter 2. Corneal Trauma
Chapter 3. Trauma to the Anterior Chamber and Lens
Chapter 4. Post-Refractive Surgery Trauma
Chapter 5. Glaucoma Considerations
Chapter 6. Eyelids
Chapter 7. The Lacrimal System
Chapter 8. Enucleation
Chapter 9. Orbit
Chapter 10. Retina and Posterior Segment Injuries
Chapter 11. Sympathetic Ophthalmia
Chapter 12. Optic Nerve, Visual Pathways and Oculomotor System
Chapter 13. Pediatric Ocular Trauma
Chapter 14. European Perspective of Ocular Trauma Management: Diagnostic and Therapeutic Considerations Based on Our Experience.

Summary: This book covers all essential evidence on perioperative care and anesthetic concerns for cancer surgeries, including the evaluation and assessment of patients' schedule for cancer surgeries, perioperative anesthetic management of various cancers, perioperative analgesia for cancer surgeries, and issues related to inoperable cancers. It reviews anesthetic considerations of all cancer types as there is a wide variation in anesthetic requirements in this subset of patients. Cancer surgeries are on the rise worldwide and healthcare facilities with cancer as a core specialty are emerging quickly around the globe. As cancer is on rise and efficient surgical management is available, more and more patients are being treated surgically. However, cancer surgeries are complicated, have varied concerns and these are not covered sufficiently in presently available textbooks of anesthesiology. This book fulfills the growing need for complete and comprehensive textbook of onco-anesthesia and fills the gap in the current texts that do not exclusively cover anesthesia for cancer surgeries. This textbook serves as a comprehensive but quick guide for trainee residents/fellows and practicing anesthesiologists, clinicians and surgeons.

Contents:
Overview of cancer
Drugs, fluid and cancers
Perioperative care in cancer patients
Preoperative assessment of cancer patients
Airway management of cancer patients
Anesthesia for lung cancers
Anesthesia for esophageal cancers
Anesthesia for gastrointestinal and hepatobiliary cancers
Anesthesia for endocrine cancers
Anesthesia for thyroid surgeries
Anesthesia for head and neck cancers
Anesthesia for airway surgeries
Anesthesia for oto-rhino-larnygology cancers
Anesthesia for brain and spine tumors
Anesthesia for cardiac tumors
Anesthesia for bone tumors and soft tissue tumors
Anesthesia for gynecological and urogenital cancers
Anesthesia for mediastinal tumors
Anesthesia for pediatric cancers
Anesthesia for Interventional procedures in cancer patients
Anesthesia for onco-surgeries with HIPEC
Intraoperative analgesia in cancer surgeries
Postoperative analgesic techniques in cancer surgeries
Persistent post-surgical pain
Phantom pain after cancer surgery
Critical care of cancer patients
Anesthesia for palliative surgeries
Palliative care for advanced cancers
Whole lung lavage
Anesthesia for radiation therapy procedures.

Summary: Bringing together more than a decade of dedicated investigation and clinical work, this unique textbook is a unified, comprehensive source for oncofertility research and medical practice that is both authoritative and up-to-date. It will serve as the primary oncofertility reference for the various medical disciplines that must be coordinated to provide care for young cancer patients. Moreover, it contains case studies that are prismatic for new entrants into the field. The book is organized around the major themes of the discipline and includes current research, clinical practice, emerging technologies and didactic questions and is divided into six thematic sections: Fertility implications in both oncologic and non-oncologic settings Options for fertility preservation, both male and female Care of the oncofertility patient, including contraception and pregnancy considerations Oncofertility in clinical practice, from setting up a new program to genetic counseling and communication Ethical and legal considerations Advances in the basic science of oncofertility In each chapter, bulleted key learning points and review study questions bookend the text. Six additional sections, comprised exclusively of clinical case studies illustrating the management of both oncologic and non-oncologic conditions, add to the pedagogical value of the text. Timely and utilizing the best current evidence, Textbook of Oncofertility Research and Practice: A Multidisciplinary Approach will be an invaluable resource for students, residents, fellows and professionals in reproductive endocrinology, pediatric endocrinology, adult and pediatric oncology, adult and pediatric urology, breast surgery, radiation oncology and allied professions where iatrogenic treatments or genetic conditions result in infertility. .

Contents:
Part I: Fertility Implications in Oncologic and Non-Oncologic Settings
Fertility Risk with Cancer Therapy
Childhood Cancer: Fertility and Psychosocial Implications
Cancer Genetics: Risks and Mechanisms of Cancer in Women with a Hereditary Predisposition to Epithelial Ovarian Cancer
Fertility Preservation in Patients with Disorders (Differences) of Sex Development
Fertility Preservation in Patients with Gender Dysphoria
Part II: Options for Preserving Fertility
Embryo and Oocyte Banking
Ovarian Tissue Cryopreservation and Transplantation
Surgical and Pharmacologic Fertility Preservation: The Role of Ovarian Transposition and Medical Suppression
Fertility Preservation Options for Female Pediatric and Adolescent Oncology Patients
Optimal Technique for Laparoscopic Oophorectomy for Ovarian Tissue Cryopreservation in Pediatric Girl
Fertility Preservation in Adult Male Cancer Patients
Part III: Care of the Opatient
Assessing Ovarian Reserve
Contraception and Menstrual Suppression for Adolescent and Young Adult Oncology Patients
Female Sexual Function in Childhood, Adolescent, and Young Adult Cancer Survivors
Pregnancy Considerations in Patients with Cancer and Cancer Survivors
Assessing Testicular Reserve in the Male Oncology Patient
Male Fertility Preservation: Current Options and Advances in Research
Male Sexuality
Part IV: Oncofertility in Clinical Practice
Setting Up an Oncofertility Program
Building a Pediatric Oncofertility Practice
The Fertility Preservation (FP)
Genetic Counselors: Bridging the Oncofertility Information Gap
Psychosocial Impact of Cancer-Related Infertility
Oncofertility Consults in the REI Setting
The Birds and the Bees and the Bank: Talking with Families About Future Fertility Amidst a Cancer Diagnosis
Patient and Family Tools to Aid in Education and Decision-Making About Oncofertility
Establishing Insurance Coverage for Iatrogenic Infertility
Part V: Ethical and Legal Considerations in Oncofertility
Legal Issues in Oncofertility Treatment
Adoption in the Cancer Setting
Common Ethical Issues in Oncofertility
The Importance of Disclosure for Sexual and Gender Minorities in Oncofertility Cases
Ethics of Posthumous Reproduction
Part VI: Basic Science Advances in Oncofertility
Fertility Preservation and Restoration in Pediatric Males
Uterus Transplantation
Protecting and Extending Fertility for Females of Wild and Endangered Mammals
Part VII: Case Studies: Egg Banking
Cervical Cancer
Large Tumors: Conservative Surgery, Ovarian Transposition, Oocyte and Ovarian Tissue Cryopreservation, a Combined Approach
Oocyte Cryopreservation in the Setting of Cervical Cancer
Alternative Stimulation Protocols
Oncofertility in the Premenopausal Breast Cancer Patient
Oncofertility Case Study: Breast Cancer in a 33 Year Old Woman
Fertility Preservation: Convergence of Newly Diagnosed Breast Cancer, Desired Fertility and Polycystic Ovary Syndrome
Fertility Preservation for a Transgender
Fertility Preservation in an Adolescent with an Ovo-Testicular Disorder of Sexual Development
Case Presentation: Adoption in the Cancer Setting
Part VIII: Case Studies: Embryo Banking
In Vitro Activation Following Ovarian Tissue Cryopreservation: A Case of Patient with POI
Fertility Preservation in Young Women with Breast Cancer : A Case Study
Childhood Cancer: Secondary Malignancy and Fertility Implications
Fertility Preservation at an Advanced Reproductive Age: When Hope and Reality Collide
Part IX: Case Studies: Ovarian Tissue Cryopreservation
Case Presentation: Ovarian Tissue Cryopreservation and Subsequent Transplantation in the Setting of Lymphoma
Ovarian Tissue Cryopreservation in a Rare Case of a Pregnant Woman with Acute Leukemia
Part X: -Case Studies: Adult Male Fertility Preservation
Case Presentation: Sperm Banking in Patient Diagnosed with Acute Myeloid Leukemia
Management of Male Infertility Secondary to Chemotherapeutic Agents During Childhood Cancer Treatment
Part XI: Case Studies: Pediatric Male Fertility Preservation
Assessing and Supporting Adolescent Boys Having Fertility Preservation
Fertility Preservation Approaches to Patients with Leukemic Involvement of the Testes
Testicular Tissue Cryopreservation Prior to Hematopoietic Stem Cell Transplant: Two Case Studies Illustrating Family Decision-Making
Adolescent Testicular Sperm Retrieval
Spontaneous Conception in a Breast Cancer Woman Carrying a BRCA2 Mutation: When Two Children is Not Enough
Part XII: Case Studies: Pediatric Female Fertility Preservation
Fertility Preservation in a Pre-Menarchal Girl
A Clinical Case of Fertility Preservation in an Adolescent with Hodgkin Lymphoma
Case Study of Post-Pubertal Adolescent Female Undergoing Ovarian Tissue Cryopreservation and Oophoropexy Prior to Gonadotoxic Therapy
Fertility Preservation in a Female Adolescent with a Hemoglobinopathy.

Summary: Textbook of Palliative Care is a comprehensive, clinically relevant and state-of-the art book, aimed at advancing palliative care as a science, a clinical practice and as an art. Palliative care has been part of healthcare for over fifty years but we still find ourselves having to explain its nature and practice to colleagues and to the public in general. Healthcare education and training has been slow to recognize the vital importance of ensuring that all practitioners have a good understanding of what is involved in the care of people with serious or advanced illnesses and their families. However, the science of palliative care is advancing and our understanding concerning many aspects of palliative care is developing rapidly. The book is divided into separate sections for ease of use. Over 100 chapters written by experts in their given fields provide up-to-date information on a wide range of topics of relevance to those providing care towards the end of life no matter what the disease may be. We present a global perspective on contemporary and classic issues in palliative care with authors from a wide range of disciplines involved in this essential aspect of care. The Textbook includes sections addressing aspects such as symptom management and care provision, organization of care in different settings, care in specific disease groups, palliative care emergencies, ethics, public health approaches and research in palliative care. This Textbook will be of value to practitioners in all disciplines and professions where the care of people approaching death is important, specialists as well as non-specialists, in any setting where people with serious advanced illnesses are residing. It is also an important resource for researchers, policy-and decision-makers at national or regional levels. Neither the science nor the art of palliative care will stand still so we aim to keep this Textbook updated as the authors find new evidence and approaches to care.

Contents:
Approach and Nature of Palliative Care
Quality of Life
Global Aspects of Palliative Care
Challenges and Future Directions of Palliative Care
Organization of Palliative Care in Different Parts of the World
Policies on Palliative Care in Different Parts of the World
Palliative Care, Towards a New Definition
Physical, Psychological/Psychiatric, Social and Spiritual Problems and Symptoms
Pain and Pain Management
Palliative Management of Breathlessness
Fatigue
Edema and Lymphedema
Gastrointestinal Symptoms: Constipation, Diarrhea, and Intestinal Obstruction
Gastrointestinal Symptoms: Nausea and Vomiting
Cachexia/Anorexia and Feeding Difficulties
Mouth
Skin Symptoms
Swallowing Difficulties
Sleep Difficulties
Psychological Symptoms
Delirium and Palliative Care
Neurological Symptoms
Genitourinary Symptoms
End-of-life Symptoms
Gastroparesis and Cancer-Related Gastroparesis
Advance Care Planning in Palliative Care
Prognostication in Palliative Care
Spirituality in Palliative Care
Access to Palliative Care
Integrated Palliative Care: Clinical, Organizational, and Health System Perspectives
Family Focused Care Span
Grief and Bereavement
Rehabilitation in Palliative Care
Dietetics and Nutrition in Palliative Care
Mouth Care
Creative Art Making in Palliative Care
Music Engagement and Therapeutic Music
Sexuality and Intimacy
Interprofessional Practice in Palliative Care
Generalists and Specialist Palliative Care
Nursing and Palliative Care
Self-Care and Palliative Care
End of Life Care
Self-management in Palliative Care
Education and Palliative Care, Overview
Palliative Care in Rural Settings
Home Care, Primary Care
Palliative Care in Residential Settings
Hospital Care
Palliative Care in the Intensive Care Unit (ICU)
Volunteers in Palliative Care
Palliative Care and Cancer
Palliative Care and Neurodegenerative Diseases
Palliative Care and Stroke
Palliative Care in Heart Failure
Palliative care of Respiratory Disease in Primary Care
Palliative Care and Liver Diseases
Palliative Care in Kidney Disease
Palliative Care and Endocrine Diseases
Palliative Care in Chronic Illness and Multimorbidity
Palliative care in dementia
Dealing with a Wound in Palliative Care
Pressure Area Management in Palliative care
End of Life Health Care Experiences of Indigenous People and Ethnic Minorities; the example of Canada
Palliative Care, Frailty and Older People
Palliative Care of Pediatric Populations
Palliative Care and Intellectual Disability
Palliative Care of Indigenous Peoples and Peoples of Different Ethnicity
Hypercalcemia of Malignancy
Thromboembolism and bleeding
Spinal Cord Compression
Superior Vena Cava Obstruction
Acute Cancer Pain Syndromes in Palliative Care Emergencies
Acute Dyspnoea
Neutropenic Sepsis
Seizures
Tumor Lysis Syndrome
Suicide and Attempted Suicide
Transfer to a Preferred Place of Death
Challenging Family Dynamics
Delirium as a Palliative Care Emergency
Distinguishing and Managing Severe Psychological and Psychiatric Distress
End-Of-Life Decisions
Sedation and Terminal Sedation
Nutrition and Hydration in Palliative Care
Ethics of home-coming
Request for Assisted Suicide
Public Health and Epidemiological Research in Palliative Care
Development and Evaluation of Complex Interventions in Palliative Care
Mixed Method Research in Palliative Care
Ethics in Palliative Care Research
Evidence based Practice in Palliative Care
New Public Health Approaches to End of Life Care
A public health approach to integrate palliative care into a country's health care system: guidance as provided by the WHO
Measuring Cost-Effectiveness in Palliative Care
Financial Aspects of Inpatient Palliative Care
Financial Aspects of Outpatient Palliative Care
Serious Illness and Out-of-Pocket Spending.

Summary: This textbook provides a practically applicable resource for understanding the surgical oncology management of pancreatic cancer. It discusses relevant aspects of anatomy and pathophysiology along with the latest diagnostic techniques. Insightful descriptions are then provided detailing how to perform critical surgical procedures when treating these patients. Relevant perioperative management strategies and emerging themes in cancer biology critical to understanding and treating the disease are also described. The need for cross-discipline collaboration to facilitate and enhance innovation within the discipline is reinforced throughout the text. Each chapter presents the relevant current clinical standards along with areas of controversy in both research and clinical practice within "pearls and pitfalls" sections. Textbook of Pancreatic Cancer: Principles and Practice of Surgical Oncology is a detailed work covering the basic material important to trainees as well as advanced curriculum for established specialists in the field from a multi-disciplinary perspective. Therefore, it is crucial resource for all practicing and trainee professionals who encounter these patients in their day-to-day clinical practice. .

Contents:
Intro
Foreword
Foreword from ESSO
Foreword from the President of IHPBA
Foreword from the President of the AHPBA
Preface
Contents
Contributors
Part I: Pancreatic Cancer Disease Burden
Chapter 1: Risk Factors for Pancreatic Cancer
1.1 Introduction
1.2 Age, Gender and Race
1.3 Pancreatitis (Acute, Chronic and Hereditary)
1.3.1 Chronic Pancreatitis
1.3.2 Acute Pancreatitis
1.3.3 Hereditary Pancreatitis
1.4 Tobacco Smoking
1.5 Alcohol Consumption
1.6 Body Mass Index and Obesity
1.7 Diabetes Mellitus
1.8 Dietary Patterns 1.9 Poor Oral Hygiene
1.10 ABO Blood Group
1.11 Potential Risk Factors
1.12 Study Design and Ongoing Epidemiological Projects
1.13 Conclusions
References
Chapter 2: Epidemiology of Pancreatic Cancer
2.1 Introduction
2.2 Worldwide Incidence
2.3 Trends in Incidence
2.3.1 Data from The Netherlands
2.3.2 Data from Austria
2.3.3 Data from Canada
2.3.4 Data from Puerto Rico
2.3.5 Data from the USA
2.4 Worldwide Mortality
2.4.1 Data from The Netherlands
2.4.2 Data from Austria
2.4.3 Data from Canada
2.4.4 Data from Puerto Rico 2.4.5 Data from the USA
2.5 Conclusion
References
Chapter 3: Hereditary Syndromes and Pancreatic Cancer
3.1 Introduction
3.2 Hereditary Tumour Predisposition Syndromes
3.2.1 Peutz-Jeghers Syndrome
3.2.2 Familial Atypical Multiple Mole Melanoma and Pancreatic Cancer Syndrome (FAMMM)
3.2.3 Hereditary Breast and Ovarian Cancer Syndrome
3.2.4 PALB2 Gene Mutations
3.2.5 ATM Gene Mutations
3.2.6 Lynch Syndrome
3.3 Hereditary Pancreatitis
3.4 Other Tumour Predisposition Syndromes
3.4.1 Li Fraumeni Syndrome
3.4.2 Familial Adenomatous Polyposis 3.4.3 Germline Mutations in Other Cancer Genes
3.5 Testing and Tools
3.6 Surveillance/Screening Recommendations
3.7 Conclusion
References
Chapter 4: Familial Pancreatic Cancer
4.1 Introduction
4.2 Familial Pancreatic Cancer
4.3 Pancreatic Cancer Susceptibility Genes in Patients with Familial Pancreatic Cancer
4.3.1 ATM
4.3.2 BRCA1, BRCA2, PALB2
4.3.3 CDKN2A
4.3.4 Hereditary Pancreatitis Genes
4.3.5 Other Inherited Syndromes
4.4 Pancreatic Cancer Susceptibility Genes in Patients with Sporadic PDAC 4.5 Pancreatic Cancer Susceptibility Genes in Patients with Pancreatic Cancer Precursor Lesions
4.6 Screening for Patients with Pathogenic Germline Variants
4.7 Conclusion
References
Part II: Education, Training and Quality of Care
Chapter 5: Education and Training in Pancreatic Surgery
5.1 Structure of Training Pathways
5.1.1 North-American Training Programmes
5.1.2 European Training Programmes
5.1.3 Australasian Programmes
5.1.4 Effect of Training Programmes on Clinical Outcomes
5.1.5 Workforce Prediction
5.2 Standards of Training
5.2.1 Period of Training

Summary: The latest edition of this textbook provides a comprehensive, state-of-the-art overview of the major issues specific to the field of pediatric gastroenterology, hepatology, and nutrition. The textbook begins with a section on gastroenterology and nutrition that presents the overall scope of issues encountered in children suffering from disorders of the gastrointestinal tract, pancreas, and/or presenting nutritional issues, as well as current and future prospects on the use of prebiotics, probiotics, and postbiotics. The second section is centered around hepatology, reviewing congenital and acquired disorders of the biliary tract and liver, as well as analyzing available diagnostic and therapeutic procedures and future perspectives. Written by experts in the field, Textbook of Pediatric Gastroenterology, Hepatology and Nutrition: A Comprehensive Guide, Second Edition is an indispensable resource for students, trainees, and clinicians, sure to distinguish itself as the definitive reference on this topic.

Summary: This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

Contents:
1. Generalities:Â Embryology of CNS.-Neurologic development and objective neurological examination of the infant and the child
Principles of neuroimaging.-Neurologic development and objective neurological examination of  the infant and the child
Physiological responses of the newborn, infant and child to neurosurgical trauma.-Preoperative evaluation, anesthesiological and intensive care management.-Pediatric chemotherapy.-Pediatric radiotherapy.-2. Congenital brain malformation and acquired disorders:Â Encephaloceles, meningoceles, dermal sinuses
Chiari malformations (types II, III, IV) .-Craniopagus
Physiology and abnormalities of CSF dynamics (including infantile benign hydrocephalus and benign intracranial hypertension) .-Hydrocephalus: Clinical presentation according to age and etiology.-Pathological changes induced by the hydrocephalus/ compensative changes.-Hydrocephalus: Neuroimaging.-Fetal hydrocephalus and its treatment in utero.-Posthemorrhagic hydrocephalus.-Postinfective hydrocephalus.-Multiloculated hydrocephalus.-Aqueductal stenosis and hydrcephalus.-X-linked, metabolic hydrocephalus.-Hydrocephalus associated to MM.-Hydrocephalus associated to tumors.-Medical treatment of hydrocephalus.-Surgical treatment of hydrocephalus based on CSF shunt devices.-In-depth view: Functional chracteristics of CSF shunt devices (pros and cons) .-In-depth view: How to perform a V-P CSF shunt.-In-depth view: How to perform a V-A CSF shunt.-In-depth view: How to perform a lumbo-peritoneal CSF shunt.-In-depth view: How to perform a pleural, glad bladder shunt.-In-depth view: How to perform a subgaleal shunt.-In-depth view: External CSF shunts.-Infective, mechanical and functional complications in the surgical treatment of hydrocephalus.-Late complications following surgical treatment of hydrocephalus.-Endoscopic treatment of hydrocephalus.-In-depth view: How to perform an endoscopic third-ventricle cisternostomy.-In-depth view: How to perform an endoscopic plexectomy.-Complications following endoscopic treatment of hydrocephalus.-Arachnoid cysts.-Dandy-Walker malformations/variants.-Cortical dysplasia.-Neurocutaneous syndromes.-Neurofibromatosis.-SturgeWeber.-Tuberous sclerosis.-HippelLindau.-Hemimegalencephaly.-Cerebrocutaneous melanosis
Encephalo cutaneous lipomatosis.-3. Cerebrovascular diseases:Â Vein of Galen aneurysmal malformations.-Artero-venous malformations.-Venous angiomas and cavernomas.-Cerebral aneurysms.-Moya-moya disease.-4. Congenital malformations of the skull and its coverings:Â Craniosynostoses: Management Issues and Evolution in concepts.-Craniosynostoses: Genetic base, genes, chromosomes and resulting syndromes.-Craniosynostoses: Lessons learned from animal models.-Sagittal synostoses.-Coronal (uni and bilateral) synostoses.-Metopic synostoses.-Lambdoid synostoses.-Non syndromic plurisutural synostoses (oxycephaly, Mercedes) .-Syndromic synostoses.-Secondary synostoses (Metabolic, Iatrogenic, osteopetrosis, etc) .-In-depth view: ICP in craniosynostosis.-In-depth view: Neuropsychological evaluation in craniosynostosis.-In-depth view: Psycho-Sociological repercussions of craniosynostosis.-In-depth view: Deformational plagiocephaly.-In-depth view: Management of craniosynostosis: Evaluation of results.-In-depth view: Blood sparing and anesthesiological issues in craniosynostosis.-In-depth view: Osteogenic distraction.-In-depth view: Endoscopy assisted techniques.-In-depth view: Spring assisted distraction.-In-depth view: Bone splitting and materials.-Scalp agenesis. .-Â 5. Head Injuries:Â Birth related head traumas.-Accidental head traumas.-Non-accidental head injuries.-Cranial decompression.-Outcomes, principles of rehabilitation.-6. Infections: Meningitis: neurosurgical implications
Encephalitis.-Empyemas and brain abscesses.-Parasitic infestations, fungal and TB.-Â 7. Neoplasms:Â Genetic basis and classification of cerebral neoplasms.-Familial syndromes.-Congenital and infantile tumors.-Cerebral gliomas.-Thalamic gliomas.-Optic pathways gliomas.-Pituitary adenomas.-Craniopharyngiomas and Rathke cysts.-Pineal region tumors.-Brainstem tumors.-Cerebellar astrocytomas.-Medulloblastomas
Ependymomas.-Meningiomas
Skull base tumors.-Skull tumors
-8. Functional disorders:Â Epilepsy: genetic forms and sporadic forms.-Medical intractable epilepsy: preoperative evaluation.-Catastrophic epilepsy and hemispherectomy.-Temporal lobe epilepsy surgery.-Extra-temporal epilepsy surgery.-Palliative surgical techniques (VNS, Callosotomy) .-Neuromodulation.-Spasticity.-Movement disorders.-9. Congenital and developmental spinal disorders:Â Genetic basis of neural tube defects.-Classification of spinal dysraphic malformations according to embryogenesis: Gastrulation defects and Split cord malformation.-Primary neurulation defects: 1 Open neural tube defects.-Primary neurulation defects : 2 Limited dorsal myeloschisi (LDM) .Dermoid and dermal sinus tracts.-Secondary neurulation defects -1: Thickened filum terminale; Retained medullary cord.-Secondary neurulation defects -2: Terminal myelocystocoele.-Mixed primary and secondary neurulation defects: spinal cord lipomas.-Antenatal management of spinal dysraphysm-1: Imaging and diagnosis of antenatal spinal and spinal cord malformations.-Antenatal management of spinal dysraphysm-2: Antenatal surgery of myelominingocoele.-Caudal agenesis and associated spinal cord malformations.-Spinal cord and vertebral arteriovenous malformation and fistula.-Intraspinal cysts including syringomyelia unrelated to Chiari Malformation.-Scoliosis and other congenital vertebral anomalies. Â 10. Craniovertebral Junction Anomalies: Embryology, classification, and surgical management of bony malformations of the craniovertebral junction.-Chiari I Malformation and associated syringomyelia.-Anterior surgical approaches to the craniovertebral junction and upper cervical spine. Â 11. Spine and spinal cord neoplasms: Intramedullary tumours
Extramedullary tumours.-Vertebral tumours. Â 12. Spinal trauma: Spine and spinal cord injuries in children: General aspects including Pure ligamentous injuries in children.-Spinal cord injury without radiographic abnormality (SCIWORA) .-Atlantooccipital dislocation (AOD) in children.-Atlantoaxial rotatory fixation (AARF) in children.-Outcome and principles of spinal cord rehabilitation in children. Â 13. Infectious diseases of the spine:Â Tuberculosis of the spine.-Bacterial, fungal, and other non-tuberculous infections of the spine, including intraspinal abscesses.-Juvenile disc diseases of the spine including infectious and non-infectious acute discitis.-14. Intraoperative Neurophysiology Monitoring:Â Intraoperative neurophysiology monitoring for surgery of the brain.-Intraoperative neurophysiology monitoring for surgery of the spine and spinal cord.

Summary: This book documents the state of the art in pediatric neurosurgery with the intention of providing a comprehensive guide to the management of the full range of pediatric neurosurgical disorders that will aid in the delivery of optimal care. Detailed practical instruction, taking into account recent advances, is provided on the neurosurgical treatment of congenital brain malformations, cerebrovascular diseases, head injuries and spinal trauma, infections, functional disorders, congenital and developmental spinal disorders, and brain and spinal tumors. Pearls and pitfalls are highlighted, and attention drawn to the most useful tips and tricks. Information is also included on relevant related topics, including the principles of neuroimaging, the physiological responses of newborns, infants, and children to neurosurgical trauma, preoperative evaluation, anesthesiology and intensive care, and other forms of therapy. The authors are renowned experts in the field, and the text is supported by a wealth of high-quality images. Handbook of Pediatric Neurosurgery will be of value for neurosurgeons of all levels of experience, as well as for pediatricians, neuroradiologists, neuropathologists, and neuro-oncologists.

Contents:
Structure and function
Genetics and pediatric rheumatic diseases
Mechanistic investigation of pediatric rheumatic diseases
Inflammation and its mediators
Adaptive immunity and autoimmunity
Understanding clinical investigations
Clinical outcome measures in pediatric rheumatic diseases
Pain and its assessment
Imaging in pediatric rheumatic diseases
Laboratory investigations
Principles in the management of patients with rheumatic disease
Global issues in pediatric rheumatology
Therapeutics : nonbiologics
Therapeutics : biologics and small molecules
Nonmedical therapies in pediatric rheumatic diseases
Juvenile idiopathic arthritis : classification and basic concepts
Systemic juvenile idiopathic arthritis
Polyarticular juvenile idiopathic arthritis
Oligoarticular juvenile idiopathic arthritis
Enthesitis-related arthritis
Psoriatic juvenile idiopathic arthritis
Uveitis in juvenile idiopathic arthritis
Systemic lupus erythematosus, mixed connective tissue disease, and undifferentiated connective tissue disease
Antiphospholipid syndrome
Neonatal lupus erythematosus
Juvenile dermatomyositis and other inflammatory muscle diseases
Juvenile systemic sclerosis
Localized scleroderma and eosinophilic fasciitis
Sjögren syndrome and immunoglobulin-G disease
Raynaud phenomenon and vasomotor syndromes
Inflammatory central nervous system disorders
Vasculitis and its classification
Immune complex small-vessel vasculitis : IGA vasculitis (Henoch-Schönlein) and hypersensitivity vasculitis
Polyarteritis nodosa
Kawasaki disease
Antineutrophil cytoplasmic antibody associated vasculitis
Takayasu arteritis and other vasculitides
Behçet disease
Periodic fever syndromes and other inherited autoinflammatory diseases
Autoinflammatory bone diseases
Pediatric sarcoidosis
Macrophage activation syndrome
Primary immunodeficiencies and rheumatic diseases
Infectious arthritis and osteomyelitis
Lyme disease
Reactive arthritis
Skeletal malignancies and related disorders
The impact of rheumatic diseases and their treatment on bone strength development in childhood
Skeletal dysplasias
Noninflammatory musculoskeletal pain
Musculoskeletal manifestations of inflammatory bowel disease
Musculoskeletal manifestations of systemic disease
Pain amplification syndromes
Primary disorders of connective tissue.

Summary: This book is for personalized medicine as a prescription of specific treatments and therapeutics best suited for an individual and considersgenetic as well as environmental factors that influence responses to therapy. Best approaches are described for integration of all available technologies for optimizing the therapy of individual patients. This comprehensive third edition covers the latest advances in personalized medicine and several chapters are devoted to various specialties, particulary cancer which is the largest area of application. The book discusses the development of personalized medicine and various playersin it such as companies, academic institutions, the government, and the public as the consumer of healthcare. Additionally, the roles of bioinformatics, electronic health records, and digital technologies for personalized medicine are discussed. Textbook of Personalized Medicine, 3rd Edition serves as a convenient source of information for students at many levels and in a wide range of fields, including physicians, scientists, and decision makers in the biopharmaceutical and healthcare industries.

Summary: "It was a remarkable 32 years ago that the first edition of Strom's Pharmacoepidemiology was published. The preface to that book stated that pharmacoepidemiology was a new field with a new generation of pharmacoepidemiologists arising to join the field's few pioneers. Over the ensuing 32 years, the field indeed has grown and no longer deserves to be called "new." Many of those "new generation" scientists (including two of the editors of this book) are now "middle-aged" pharmacoepidemiologists. Despite its relatively brief academic life, a short history of pharmacoepidemiology and review of its current state will set the stage for the purpose of this textbook. Pharmacoepidemiology originally arose from the union of the fields of clinical pharmacology and epidemiology. Pharmacoepidemiology studies the use of and the effects of medical products in large numbers of people and applies the methods of epidemiology to the content area of clinical pharmacology. This field represents the science underlying postmarketing medical product surveillance, studies of the effects of medical products (i.e., drugs, biologicals, devices) performed after a product has been approved for use. In recent years, pharmacoepidemiology has expanded to include many other types of studies, as well"-- Provided by publisher.

Contents:
What is Pharmacoepidemiology? / Brian L. Strom
Study Designs Available for Pharmacoepidemiologic Studies / Brian L. Strom
Sample Size Considerations for Pharmacoepidemiologic Studies / Brian L. Strom
Basic Principles of Clinical Pharmacology Relevant to Pharmacoepidemiologic Studies / Jeffrey S. Barrett
When Should One Perform Pharmacoepidemiologic Studies? / Brian L. Strom
Views from Academia, Industry, Regulatory Agencies, and the Legal System / Joshua J Gagne, Jerry Avorn, Nicolle M Gatto,Jingping Mo, Gerald J. Dal Pan, June Raine, Shinobu Uzu, Aaron S. Kesselheim, Kerstin N. Vokinger
Postmarketing Spontaneous Pharmacovigilance Reporting Systems /
Gerald J. Dal Pan, Marie Lindquist, and Kate Gelperin
Overview of Electronic Databases in Pharmacoepidemiology / Brian L. Strom
Encounter Databases / Tobi Gerhard, Yola Moride, Anton Pottegard, Nicole Pratt
Electronic Health Record Databases / Daniel Horton, Harshvinder Bhullar, Francesca Cunningham, Janet Sultana B. Pharm (Hons.), and Gialuca Trifiro
Primary Data Collection for Pharmacoepidemiology / Priscilla Velentgas
How Should One Perform Pharmacoepidemiologic Studies? Choosing Among the Available Alternatives / Brian L. Strom
Validity of Drug and Diagnosis Data in Pharmacoepidemiology / Mary Elizabeth Ritchey, Suzanne L West, and George Maldonado
Assessing Causality from Case Reports / Bernard Begaud, and the late Judith K. Jones
Molecular Pharmacoepidemiology / Christine Y Lu and Stephen E. Kimmel
Bioethical Issues in Pharmacoepidemiologic Research / Laura E Bothwell, Annika Richterich, and Jeremy Greene
The Use of Randomized Controlled Trials in Pharmacoepidemiology /
Robert Reynolds, Samuel M. Lesko, Allen A. Mitchell
Pharmacoeconomics: Economic Evaluation of Pharmaceuticals / Kevin A. Schulman
Patient Engagement and Patient Reported Outcomes / Esi Morgan
The Use of Meta-analysis in Pharmacoepidemiology / Jesse A. Berlin, Vrenda J Crowe, H Amy Xia, and Stephen JW Evans
Studies of Medication Adherence / Julie Lauffenburger, Trisha Acri, and Robert Gross
Advanced Approaches to Controlling Confounding in Pharmacoepidemiologic Studies / Sebastian Schneeweiss and Samy Suissa
Special Applications of Pharmacoepidemiology / David Lee, Björn Wettermark, Christine Y. Lu, Stephen B. Soumerai, Robert T. Chen, Sharon-Lise T. Normand, Art Sedrakyan, Danica Marinac-Dabic, Daniel B. Horton, Sonia Hernandez-Diaz, Tamar Lasky, Krista F. Huybrechts, Claudia Manzo, Emil Cochino, Hanna M. Seidling, David W. Bates, Bennett Levitan,
Rachel DiSantostefano, Scott Evans
The Future of Pharmacoepidemiology / Brian L. Strom, Stephen E. Kimmel, and Sean Hennessy.

Summary: Derive the maximum diagnostic information from interviewing and examining patients with Textbook of Physical Diagnosis. Employing a compassionate, humanistic approach, Dr. Swartz explores how cultural differences can influence communication, diet, family relationships, and health practices and beliefs, and demonstrates that your interpersonal awareness is just as essential in physical diagnosis as your level of technical skill. This medical reference book features numerous high-quality color images, an easy-to-use design, and detailed descriptions of exam techniq.

Contents:
The interviewer's questions
The patient's responses
Understanding complementary and alternative medicine
Putting the history together
Deconstructing racism and bias in clinical medicine
The physical examination
Assessment of nutritional status
The skin
The head and neck
The eye
The ear and nose
The oral cavity and pharynx
The chest
The heart
The peripheral vascular system
The breast
The abdomen
Male genitalia and hernias
Female genitalia
The musculoskeletal system
The nervous system
Putting the examination together
The pregnant patient
The pediatric patient
The geriatric patient
The acutely ill or injured patient
Precision, accuracy, and critical thinking in clincal assessment
The clinical record
The focused history and physical examination
Clinical ethics and professionalism.

Summary: Filling a gap in the present inventory of Plastic Surgery Textbooks, this compact, practice-oriented study guide delivers comprehensive, clear and up-to-date information on all the basics of plastic surgery in clinical practice. Methodological rigor, together with a lean style and layout were chosen; boxes and teaching objectives are included to help memorize fundamentals. Starting from basics such as the physiology and pathology of skin and wound healing, suture techniques, dressings and dermal substitutes, grafts, flaps and microsurgical techniques, the textbook then tackles topics including malformations, skin cancer, and traumas like burns and wounds. The respective contributions were written by American, British, Italian, German, Korean and Taiwanese teaching experts in the field. Over 250 full color illustrations, line drawings, and videos support the main text: accordingly, this textbook will appeal to advanced, upper-undergraduate students and residents preparing for plastic and reconstructive surgery in-training.

Contents:
Preface
1.Plastic Surgery: From Myth to Reality
2.The skin
3.Wound healing: physiology and pathology
4.Suture Techniques
5.Dressing and Dermal Substitute
6.Grafts
7.Flaps
8.Microsurgery
9.Malformations: (Head and Neck, Hand, External genitalia)
10.Trauma (Wounds, Burns)
11.Cancer ( Skin Cancer, Melanoma, Sarcoma)
12.Maxillo Facial Surgery
13.Hand Surgery
14.Breast Surgery
15.Abdominal Wall Surgery
16.Lower Limb Surgery
17.Lymphedema
18.Nerve Surgery
19.Regenerative Surgery
20.Aesthetic Medicine and Surgery.

Summary: This textbook is a fully updated and revised third edition of a highly successful practical guide to the care of the polytrauma patient. Broadening its readership to students, this new edition comprehensively describes the clinical course of multiple and severe injuries, from the accident scene to rehabilitation. It provides essential practical information on the care of patients both with blunt and penetrating trauma to multiple body regions, and discusses the management of truncal injuries (head, chest, abdomen) as well as fractures of the extremities, pelvis and spine. Further, the book highlights associated injuries that may alter decisions concerning patients with polytrauma. This new, revised edition takes full account of recent developments, including the increasing economic pressure on health care systems, prehospital treatment, changes in trauma systems and related education, and the improved survival of polytrauma patients. Also covering improved monitoring options along with issues in late patient outcomes and rehabilitation this work will greatly assist students, emergency personnel, trauma surgeons, orthopaedic traumatologists, and anesthesiologists.

Contents:
I Introduction: 1 Impact of Trauma on Society
2: Economic Aspects of Trauma Care
3: Evidence-Based Trauma Care - the role of COTS
II ACUTE PERIOD (1 to 3 hours) / Prehospital Phase and Trauma Bay
4: Rescue Strategies and Trauma System
5: Preclinical Maganement
6: Initial Assessment and Diagnistics
7: Volume and Blood Management
8: Emergency Interventions
III PRIMARY PERIOD (First 72 hours) / Clinical Phase
PATHOPHYSIOLOGY, Ch 9: Coagulopathy
PATHOPHYSIOLOGY, Ch 10: Inflammation and Immunosupression
PATHOPHYSIOLOGY Ch 11: Remote Organ Injury
PATHOPHYSIOLOGY Ch 12: Polytrauma Scoring
CERTAIN INJURIES Ch 13: Head Injuries
CERTAIN INJURIES Ch 14: Injury of the Face
CERTAIN INJURIES, Ch 15: Chest Trauma
CERTAIN INJURIES, Ch 16: Abdominal Injuries
CERTAIN INJURIES, Ch 17: Penetrating Thorax and Abdominal Trauma
CERTAIN INJURIES Ch 18: Management of the Pelvic Ring
CERTAI INJURIES, Ch 19: Spine Fractures
CERTAININJURIES, Ch 20: Spinal Cord Injuries
CERTAIN INJURIES, Ch 21: Urological Injuries in Polytrauma
CERTAIN INJURIES, Ch 22: Gynecological Injuries /Pragnant Patient in Polytrauma
CERTAIN INJURIES, Ch 23: Vascular Injuries
CERTAIN INJURIES, Ch 24: Compartment Syndrom
SURGICAL MANAGEMENT, Ch 25: Damage Control in Abdomen and Thorax
SURGICAL MANAGEMENT, Ch 26: Fracture Management / DCO
SURGICAL MANAGEMENT, Ch 27: Managled Extremity
SURGICAL MANAGEMENT, Ch 28: Elderly Patient with Polytrauma
SURGICAL MANAGEMENT Ch 29: Polytrauma in Children
SURGICAL MANAGEMENT Ch 30: Management of Traumatic Bone Defects
SURGICAL MANAGEMENT Ch 31: Acute Soft Tissues and Bone Infections
III SECONDARY PERIOD (3 to 8 days)
ICU MANAGEMENT CH 32: DIC
ICU MANAGEMENT CH 33: Polytrauma and Sepsis
ICU MANAGEMENT CH 34: Polytrauma and Multiple Organ Failure
ICU MANAGEMENT Ch 35: General Management in the Elderly on ICU
ICU MANAGEMENT Ch 36: Clearing Patients for Surgery
ICU MANAGEMENT Ch 37: Complications
IV TERTIARY PERIOD (after 8 days) / Rehabilitation
Rehabilitation Ch 38 : Rehabilitation Strategies in Polytrauma
Rehabilitation Ch 39 : Outcome Scores
Rehabilitation Ch 40: Treatment of Acute and Chronic Osteomyelitis
Rehabilitation Ch 41: Management of Malunions and Nonunions in Patients with Multiple Injuries
Rehabilitation Ch 42: Reconstructive Strategies for Skeletal Complications
Rehabilitation Ch 43: Soft Tissue Coverage
Rehabilitation Ch 44: Treatment of Heterotopic Ossification
Rehabilitation Ch 45: Psychological Squelae After Severe Trauma
Rehabilitation Ch 46: General Outcome and Quality of Life.

Summary: This textbook provides a comprehensive, practical guide to the identification of a range of common dermatological conditions encountered within primary care. It features a problem-based approach to the topics and conditions covered. Clinical photographs, diagrams and pertinent tables along with clear learning objectives, clinical pearls and pitfalls in each chapter facilitate understanding in the diagnosis and management of a range of common dermatological conditions. Textbook of Primary Care Dermatology empowers the reader to develop their understanding of how to deal with a range of common skin, hair and nail problems. It is ideal for training and practising primary care physicians seeking a quick reference guide to use in their clinical practice and the trainee dermatologist seeking a primer on the topic. It is also suitable for other members of the primary care team including nurses, pharmacists, physician associates and clinical assistants, and it is very useful for hospital-based doctors and nurses in other disciplines who want a quick, practical reference to common dermatological problems.

Contents:
Introduction
Investigations and treatment
History taking and examination
Structure and function of the skin
Terminology in dermatology
Acne
Roaccutane
Rosacea
Papulo-pustular rashes on the face
The red face
Polycystic ovarian syndrome
Hidradenitis Suppurativa
Atopic eczema in children
Eczema and dermatitis in adults
Lichen planus
Urticaria
Allergic skin disorders
Psoriasis
Seborrhoeic dermatitis
Generalized rashes
Regional dermatology
Leg ulcers
Wound care
Red leg
Blistering eruptions
Bacterial infections
Fungal and yeast infections of skin, hair and nails
Viral infections
Paracetic and protozoal infections
Warts
Cryosurgery
Cryosurgery for warts
Nurse lead cryosurgery clinic
Cuteneous surgery
Local anaesthetics for skin surgery
Hair loss and excessive hair growth
Nail problems
Lesion recognition
Pigmented lesions
Non pigmented lesions
Congenital Nevi (moles) in Newborns and Children
Skin cancer and pre cancer
Dermoscopy for the General Practitioner
Photobiology (the sun and the skin)
Disorders of pigmentation
Ethnic dermatology (skin of colour)
Pregnancy rashes
Paediatric dermatology
Childhood exanthems (rashes with a fever)
Rashes in the elderly
Genodermatoses ( hereditary skin diseases)
Skin in systemic disease
Skin and the mind
Hyperhydrosis (excessive sweating)
Cutaneous vasculitis
Emergency dermatology
Pruritis
Emollients
Topical steroids
Topical calcinuera inhibitors
Pharmacist and skin disease
Nurse and skin disease
Patient information leaflets
Useful websites, courses, bibliography and patient support groups.

Summary: This textbook provides a state of the art of the knowledge on the prevalence, risk and etiological factors, clinical features, assessment procedures and tools, diagnostic criteria, treatment, and prognosis of the psychiatric disorders encountered in people with intellectual disability (ID) and low-functioning autism spectrum disorder (ASD). ID and ASD represent two meta-syndromic groups of several different conditions, each with particular cognitive and communication features. People with ID/ASD display an increased prevalence of a variety of psychiatric disorders, including psychotic disorders, mood disorders, anxiety and stress-related disorders, somatoform disorders, and obsessive-compulsive disorder, as well behavioral syndromes, personality disorders, and disorders due to psychoactive substance use. This book will enable readers to understand the specificities of psychiatric disorders in the context of ID/ASD. It explains clearly how diagnostic criteria and assessment procedures for psychiatric disorders that were created for the general population have to be modified for use with ID/ASD. Above all, it will enable clinicians to overcome difficulties in diagnosis and to deliver more effective care that meets the particular needs of patients with ID/ASD.

Contents:
Chapter 1 Introduction (Bertelli, M.)
Chapter 2 Intellectual Developmental Disorders (Munir, K.)
Chapter 3 Epidemiology of Intellectual Disability (Maulik, P.)
Chapter 4 Vulnerability (Banks, R.)
Chapter 5 Borderline Intellectual Functioning (Hassiotis, A.)
Chapter 6 Problem Behaviours (Deb, S., Unwin, G., Cooper, S., Rojahn, J.)
Chapter 7 Behavioural Phenotypes (Munir, K.)
Chapter 8 Psychopathology and Phenomenology (Jung, R.)
Chapter 9 Diagnostic Issues (Moss, S.)
Chapter 10 Psychiatric Assessment (Moss, S.)
Chapter 11 Prevalence of Psychiatric Disorders (General) (Cooper, S.)
Chapter 12 Aetiology and Pathogenesis (Korb, L., Hassiotis, A., Sheehan, R.)
Chapter 13 Treatment and Intervention (Deb, S.)
Chapter 14 Non pharmacological Interventions (Didden, R., Leoni, M., Cavagnola, R., Sigafoos, J.)
Chapter 15 Outcome Measures (Bianco, A.)
Chapter 16 Other Developmental Disorders and IDD (Bertelli, M.)
Chapter 17 Specific Developmental Disorders (Munir, K., Bachman, C., Mengheri, L.)
Chapter 18 Behavioural and Emotional Disorders with Onset Usually Occurring in Childhood and Adolescence (Munir, K.)
Chapter 19 Psychotic Disorders (Hassiotis, A.)
Chapter 20 Mood Disorders (Hurley, A., Levitas, A.)
Chapter 21 Anxiety and Stress-related Disorders (Tass, M., Cooray, S.)
Chapter 22 Somatoform Disorders (Bertelli, M.)
Chapter 23 Obsessive-compulsive Disorder (Jarrett, B.)
Chapter 24 Behavioural Syndromes Associated with Physiological Disturbances and Physical Factors (Gravestock, S.)
Chapter 25 Nonorganic sleep disorders (Rossi, M., Scuticchio, D., Bianco, A., Merli, M., Bertelli, M.)
Chapter 26 Nonorganic Sexual Dysfunction (Scuticchio, D., Rossi, M., Bianco, A., Merli, M., Bertelli, M.)
Chapter 27 Dementia in People with Intellectual Disabilities (Deb, S., Strydom, A., Hithersay, R., Gomiero, T., De Vreese, L., Janicki, M., Jokinen, N., Service, K.)
Chapter 28 Other Disorders Due to Brain Damage and Dysfunction and to Physical Disease (Seidel, M.)
Chapter 29 Mental and Behavioural Disorders Due to Psychoactive Substance Use (Bertelli, M.)
Chapter 30 Personality Disorders (Cooray, S.)
Chapter 31 Co-occurrence and Differential Diagnosis (Bertelli, M.)
Chapter 32 ID & Sensory Impairment / Multiple Disability (Fellinger, J.)
Chapter 33 Training (Weber, G.)
Chapter 34 Mental Health Services (McCarthy, J., Chaplin, E.)
Chapter 35 Health costs (Romeo, R., Boadu, J., McNamara, R.)
Chapter 36 Residential Services and Community Living (Beadle-Brown, J.)
Chapter 37 Work and Occupation (Francescutti, C.)
Chapter 38 Cultural Issues (Allen-Leigh, B., Lazcano-Ponce, E., Katz, G.)
Chapter 39 Spiritual Issues (Fellinger, J.)
Chapter 40 Forensic Issues (Chaplin, E., McCarthy, J.)
Chapter 41 Human Rights (Banks, R.).

Summary: "The American Psychiatric Association Publishing Textbook of Psychopharmacology is an indispensable and comprehensive resource for clinicians and trainees who prescribe psychotropic medications. Updated to reflect the new DSM-5 classification, this revised Fifth Edition maintains the user-friendly structure of its predecessors while offering in-depth coverage of the latest research in pharmacological principles, classes of drugs, and psychiatric disorders. Introductory chapters provide a theoretical grounding in clinical applications, with topics ranging from neurotransmitters to brain imaging in psychopharmacology. The bulk of the book is devoted to various classes of drugs, including antidepressants, anxiolytics, antipsychotics, mood stabilizers, and other agents, with each class divided into chapters on specific drugs -- either new or revised to include the latest findings and trends. Finally, the section on psychopharmacological treatment addresses evidence-based principles of clinical care for the full spectrum of mental disorders and conditions -- from depression to chronic pain -- as well as for specific populations and circumstances -- from children and adolescents to psychiatric emergencies -- offering information on topics such as medication selection, combination and maintenance dosing regimens, monitoring and management of side effects, and strategies for optimizing treatment response. The book's beneficial features are many: * The section on principles of pharmacology has been revised and reorganized to incorporate recent discoveries from the fields of neurobiology, genetics, brain imaging, and epidemiology.* History and discovery, structure--activity relationships, pharmacological profiles, pharmacokinetics and disposition, mechanisms of action, indications and efficacy, side effects and toxicology, and drug--drug interactions are addressed for each agent. This consistent structure places the desired information at the clinician's fingertips and facilitates study for trainees.* Coverage of drugs approved since the last edition is thorough, encompassing new antidepressants (e.g., vortioxetine), new antipsychotics (e.g., cariprazine), and agents on the clinical horizon (e.g., ketamine).* More than 180 tables and graphs present critically important data in an accessible way. A work of uncommon scientific rigor and clinical utility, The American Psychiatric Association Publishing Textbook of Psychopharmacology provides state-of-the-art information on both the principles and the practice of psychopharmacological treatment of psychiatric disorders."--Publisher's description.

Contents:
Part I: Principles of pharmacology. Basic principles of molecular biology and genomics
Neurotransmitters and receptors in psychiatric disorders
Genetics and genomics
Psychoneuroendocrinology
Brain–immune system interactions
Principles of pharmacokinetics and pharmacodynamics
Brain imaging in psychopharmacology
Part II: Classes of psychiatric treatments: antidepressants and anxiolytics. Monoamine oxidase inhibitors
Tricyclic and tetracyclic drugs
Fluoxetine
Sertraline
Paroxetine
Fluvoxamine
Citalopram and escitalopram
Trazodone and nefazodone
Vortioxetine
Mirtazapine
Bupropion
Venlafaxine and desvenlafaxine
Duloxetine, milnacipran, and levomilnacipran
Ketamine
Benzodiazepines
Buspirone
Antipsychotics. Classic antipsychotic medications
Clozapine
Olanzapine
Quetiapine
Risperidone and paliperidone
Aripiprazole and brexpiprazole
Ziprasidone
Asenapine
Iloperidone
Lurasidone
Cariprazine
Drugs to treat extrapyramidal side effects
Drugs for treatment of bipolar disorder. Lithium
Valproate
Carbamazepine, oxcarbazepine, and licarbazepine
Gabapentin and pregabalin
Lamotrigine
Topiramate
Other agents. Agents for cognitive disorders
Sedative-hypnotics
Psychostimulants and wakefulness-promoting agents
Electroconvulsive therapy and other neuromodulation therapies
Part III: Psychopharmacological treatment. Treatment of depression
Treatment of bipolar disorder
Treatment of anxiety and related disorders
Treatment of schizophrenia
Treatment of substance-related disorders
Treatment of personality disorders
Treatment of eating disorders
Treatment of insomnia
Treatment of chronic pain
Treatment of child and adolescent disorders
Treatment during late life
Psychopharmacology during pregnancy and lactation
Treatment of psychiatric emergencies
Treatment of agitation and aggression in the elderly

Summary: This textbook aims to provide the reader with knowledge and skills on rare sexual medicine conditions. The aim is to increase awareness in healthcare providers so they improve their ability to support their patients suffering from debilitating symptoms - characterized by sexual dysfunction, somatic symptoms, and psychological disorders that persist for an extended period. The available knowledge from the medical literature and clinical experience is summarized, outlining possible pathophysiological mechanisms, and clinical management, including biological-psychological-social contributing factors according to expert opinion, are described. Written by experts in the field, this publication will be a unique scientific collection of multidisciplinary practical and clear information for urologists, gynaecologists, psychiatrists, endocrinologists, neurologists, dermatologists, primary health care professionals and psychologists. The didactical approach will be useful for professionals, residents, and students.

Contents:
Chapter 1: Introduction (Y. Reisman, F. Tripodi, L. Lowenstein)
Chapter 2: The bio-psycho-social approach in sexual medicine disorders (F. Tripodi & Y. Reisman)
Chapter 3: Penile Dysmorphic Disorder (PDD) (J. Yianni, D. Veale)
Chapter 4: Persistent Genital Arousal Disorder/Genitopelvic Dysesthesia (C. Pukall, B. Komisaruk, I. Goldstein)
Chapter 5: Post-SSRI Sexual Dysfunction (PSSD) (Y. Reisman, J.G. Pfaus, & L. Lowenstein)
Chapter 6: Post-Finasteride Syndrome (M.C. Fierro, F.A. Yafi, Y. Reisman)
Chapter 7: Orgasmic Anhedonia (Heruti RJ, Kamin R, Bitzer J.)
Chapter 8: Headache associated with sexual activity (E. Colonnello, M. Toscano, T.B. Jannini, E.A. Jannini)
Chapter 9: Post-Orgasmic Illness Syndrome (POIS) (Y. Reisman & F. Tripodi).

Summary: Written by physicians and scientists with expertise in this evolving area, Textbook of SARS-CoV-2 and COVID-19 provides a coherent, readable, and clinically relevant review of the biology, epidemiology, pathophysiology, immunology, clinical features, current treatment, and prevention strategies for the SARS-CoV-2 virus. Using both a systemic and topic-based approach, it summarizes and clarifies the extensive literature published on SARS-CoV-2 and COVID-19, includes a comprehensive bibliography, and provides answers to clinical questions at the point of care from multiple specialty perspectives.

Contents:
Epidemiology of SARS-CoV-2 and COVID-19
SARS-CoV-2: Structure, Pathogenesis, and Diagnosis
Immunology of COVID-19
COVID-19: Natural History and Spectrum of Disease
Pulmonary Manifestations of COVID-19
COVID-19 and the Cardiovascular System
Neurological Manifestations of COVID-19
Oral Cavity and COVID-19: Clinical Manifestations, Pathology, and Dental Profession
Gastrointestinal Manifestations of COVID-19
Kidney Manifestations of COVID-19
Ophthalmic Manifestations of COVID-19
Psychiatric Manifestations of COVID-19
Impact of Maternal SARS-CoV-2 Infection on the Fetus and Newborn
COVID-19 in Children and Adolescents
COVID-19: Emergency Medicine Perspectives
Therapeutics for COVID-19
Novel Therapeutic Targets for SARS-CoV-2 and COVID-19
Vaccine Basics and the Development and Rollout of COVID-19 Vaccines.

Summary: This textbook provides the most up-to-date information on shoulder surgery along with practical approaches for patient evaluation and treatments options. The book is divided into key sections, providing coverage on Soft Tissue Disorders of the Shoulder, Arthritis of the Shoulder, The Paediatric Shoulder and other miscellaneous topics relevant to treating this area. Its strong clinical focus will help residents and medical students to manage patients in a practical way, based on the most recent scientific evidence and the most effective surgical and non-surgical techniques. Thus, it will become a valuable reference and resource for young doctors and students looking to increase their professional skills and knowledge when treating shoulder injuries and disorders in clinical practice. .

Contents:
1. Sternoclavicular joint injuries
2. Clavicular fractures
3. ACJ injuries
4. Glenoid-scapular fractures
5. Proximal humeral fractures
6. Outcome assessment following shoulder trauma
7. Rehabilitation following shoulder trauma
8. Gleno-humeral instability
9. Pathology of the rotator cuff including impingement
10. Calcifying tendonitis
11. Pathology of the biceps tendon
12. The stiff shoulder
13. Muscle ruptures around the shoulder
14. Design of the polyethylene glenoid
15. Design of humeral stems
16. Results of the anatomic shoulder replacement
17. Complications in anatomic shoulder replacement
18. Design principles of the reverse prosthesis
19. Results of the reverse implant
20. Complications of the reverse implant
21. Bone augmentation in shoulder arthroplasty
22. Polyethylene augments in total shoulder replacement
23. Metal augments
24. Convertible stems
25. Management of complications of shoulder arthroplasty
26. Revision techniques in total shoulder arthroplasty
27. Stemless total shoulder replacement
28. Patient specific instrumentation
29. Rehabilitation after shoulder arthroplasty
30. Paediatric trauma around the shoulder
31. Brachial plexus / neuromuscular problems around the shoulder
32. Paediatric sports injuries including paediatric instability
33. Nerve problems around the shoulder
34. Tumours and related conditions
35. Sepsis of the shoulder
36. Clinical evaluation
37. Radiological evaluation
38. Evaluation of shoulder conditions.

Summary: This textbook provides a comprehensive, yet practically orientated overview of classic and novel sports cardiology topics, based on current evidence, guidelines, recommendations and expert experience. Numerous publications have provided guidance to these issues, but it has become increasingly difficult for both students and doctors to obtain a thorough, but practicable overview for optimal clinical care of athletes and patients. This book is intended as an educational work, filling the large gaps that are still present in the current educational guidelines for medical students and cardiology trainees. Textbook of Sports and Exercise Cardiology differs from other sports cardiology books by focusing on clear, practical recommendations based on the latest evidence, primarily targeting those who seek professional background information and education that can easily be transferred into everyday care.

Contents:
Intro
Preface
Contents
Part I: Sports Cardiology in Young Competitive Athletes
1: Definition of Athletes and Classification of Sports
1.1 Definition of Athletes
1.2 Classification of Sports
1.2.1 Mitchell Classification of Sports
1.2.2 Cardiovascular Classification of Sports
Review
Questions
Answers
References
2: The Cardiologist as Part of the Athlete Medical Team
2.1 Introduction
2.2 How Does the Cardiologist Get Started in Caring for Athletes (Sports Cardiology)?
2.3 How to Interact with Team Medical Staff 2.4 Brief History of Sports Cardiology
2.5 Knowledge Base Required to Practice Sports Cardiology: Core Competencies
Review
Questions
Answers
References
3: Athlete's Heart: Basic Physiology and Adaptation to Exercise
3.1 Historical Perspective
3.2 Cardiovascular Response to Exercise and Functional Changes in an Athlete's Heart
3.3 Electrical Changes
3.3.1 Physiologic Findings in Athletes
3.3.2 Increased QRS Voltage for LVH and/or RVH
3.3.3 Incomplete Right Bundle Branch Block
3.3.4 Early Repolarization and ST Segment Elevation 3.3.5 Sinus Bradycardia, Sinus Arrhythmia and Ectopic Atrial Rhythm
3.3.6 Low Grade AV Block
3.3.7 Borderline and Pathologic ECG Findings in Athletes
3.4 Structural Changes
3.4.1 General Aspects
3.4.2 Specific Aspects of Left Ventricular Remodelling
Review
Questions
Answers
References
4: Impact of Sporting Disciplines and Body Size on the Athlete's Heart
4.1 Impact of Sporting Disciplines on the Athlete's Heart
4.2 Historical Background (The "Morganroth Hypothesis")
4.3 Impact on the Left Ventricle
4.4 Impact on the Right Ventricle 4.5 Impact on the Atria
4.6 Impact on the Aorta
4.7 Body Size and the Need to "Normalise", "Index" or "Scale": Historical Background
4.8 Which Scaling Processes Have Been Used with "Athlete's Heart" Data?
4.9 Which Scaling Variables Are Used with "Athlete's Heart" Data?
4.10 Take Home Messages and Guidance for Future Research
Review
Questions
Answers
References
5: Sudden Cardiac Death in Athletes: Incidence, Causes and Prevention Strategies
5.1 Epidemiology
5.1.1 Prevalence
5.1.2 Incidence
5.1.2.1 Numerator
5.1.2.2 Denominator 5.2 Conditions Associated with Sudden Cardiac Death
5.3 Prevention
5.3.1 Primary Prevention in Young Athletes
5.3.2 Primary Prevention in Older Athletes
5.3.3 Secondary Prevention of SCD
Review
Questions
Answers
References
6: Medical Evaluation of Athletes: Medical History and Physical Examination
6.1 Personal History/Symptoms
6.2 Syncope/Near-Syncope
6.3 Exertional Chest Pain/Discomfort
6.4 Dyspnea and/or Reduced Exercise Capacity
6.5 Palpitations
6.6 Family History
6.7 Physical Examination
6.8 Heart Sounds
6.9 Heart Murmurs

Summary: Concise and informative, this guide is for doctors preparing to specialise in stroke care and strokologists looking for rapid but in-depth scientific guidance on stroke management. This third edition is fully revised to ensure that medical professionals are completely up-to-date in this fast-moving field. Its practical and problem-based approach covers all important issues of prevention, diagnosis, and treatment of cerebrovascular diseases, and reviews epidemiology and risk assessment. This new edition features expanded sections on topics of stroke unit management, thrombolysis, neurointerventions, cognitive impairment, secondary prevention and rehabilitation, and includes new chapters on neurointensive care and small vessel disease. Comprehensive in its coverage, the textbook includes acute assessment, imaging and emergency interventions. The authors are renowned experts in their field and have been working together in a teaching faculty for the European Master in Stroke Medicine Programme, which is supported by the European Stroke Organisation and the World Stroke Organisation.

Summary: This fully revised and expanded second edition provides a comprehensive, up-to-date overview of the fundamentals of contemporary larynx and trachea surgery, presenting the state of the art in European laryngology. The book includes the most recent developments in surgery, such as robotic surgery, as well as novel materials such as the CO2 waveguide, and describes the technical aspects of the various procedures in detail to allow readers to implement them. It particularly focuses on issues like the treatment of papilloma, the transoral surgery of T3-T4 larynx cancer and scarring of the vocal fold. The contributors are experts in the field, mainly from the European Laryngological Society and European Head & Neck Society, but also from America and Asia. This textbook is a valuable resource for ENT trainees and those superspecializing in laryngology, as well as for experienced laryngologists and head & neck surgeons. .

Contents:
Foreword
Preface
Physiology of larynx
Assessment of Voice and respiratory function
Fundamental of laryngeal surgery: approaches, instrumentation and basic microlaryngoscopic techniques
Microphonosurgery using cold steel
Laser-Assisted phonosurgery
Laryngeal Framework Surgery
Scar of the vocal fold
Voice feminization
Exercice induced laryngeal obstruction EILO
Office-based procedures
Laryngeal surgery in children
Laryngeal papillomatosis
Laryngeal trauma
Glottic airway stenosis
Subglottic and tracheal stenosis.-Tracheotomy
Neurolaryngology
Spasmodic dysphonia
Therapeutic options
Nerve reconstruction
Preoperative assesment of laryngeal cancer
HPV and laryngeal cancer.-Transoral approach for early cancers
Transoral approach for extended cancers (T3-T4).-Open partial surgery for laryngeal cancers
Total laryngectomy
Principles of salvage laryngeal surgery
Management of Tracheal Tumours
Reconstruction of the laryngeal and pharyngeal defects
Voice restoration
Robotic surgery Da Vinci
Robotic surgery flex system
Surgery for Swallowing disorders
Preoperative and postoperative speech therapy.

Contents:
Cervical spine anatomy
Approaches to the upper cervical spine
Anterior surgical approach to the cervical spine
Posterior surgical approach to the cervical spine
Anterior approaches and surgical considerations for pathology of the cervicothoracic junction
Developmental and congenital disorders of the cervical spine
Biomechanics of the cervical spine
Evaluation of the cervical spine
Radiographic and computed tomography evaluation of the cervical spine
Magnetic resonance imaging of the cervical spine
Neurophysiologic monitoring of the cervical spine
Cervical degenerative disk disease
Cervical radiculopathy
Cervical spondylotic myelopathy
Cervical deformity and treatment algorithms
Ossification of the posterior longitudinal ligament
Occipitocervical and upper cervical spine fractures
Subaxial cervical spine injuries
Spinal cord injuries and syndromes
Traumatic arterial injuries : diagnosis and management
Stingers and transient paresis
Primary tumors of the spinal cord
Primary bony tumors of the cervical spine
Metastatic disease of the cervical spine
Infections of the cervical spine
Tuberculosis of the cervical spine
Rheumatoid arthritis of the cervical spine
Ankylosing spondylitis of the cervical spine
Syringomyelia
Anterior cervical diskectomy and fusion
Anterior cervical corpectomy and fusion and hybrid techniques
Cervical disk arthroplasty
Anterior cervical foraminotomy
Laminectomy and fusion
Cervical laminoplasty
Posterior cervical endoscopic laminoforaminotomy
Osteotomies of the cervical spine
Occipitocervical fixation
C1 lateral mass and C2 pedicle screw fixation
C1-C2 transarticular screws
C2 translaminar screw fixation
Cervical pedicle screws
Lateral mass screws
Interspinous wiring
Minimally invasive techniques in the cervical spine
Image-guided navigation for cervical spine surgery
Biologics for intervertebral disk regeneration and repair
Biologics for spinal fusion
Intervertebral disk transplantation
Vascular injuries
Spinal cord and nerve injuries in the cervical spine
Tracheoesophageal injuries
Dural tear
Wound complications
Adjacent segment disease
Nonunions and implant failures of the cervical spine.

Contents:
Part I: Epidemiology and pathophysiology
Part II: Assessment
Part III: Neuropsychiatric aspects of traumatic brain injury
Cognition
Emotion
Behavior
Somatic
Part IV: Speical populations and issues
Mild brain injury
Other populations
Part V: Treatment.

Summary: This textbook focuses on the vascular biology and physiology that underlie vascular disorders in clinical medicine. Vascular biomedicine is a rapidly growing field as new molecular mechanisms of vascular health and disease are unraveled. Many of the major cardiovascular diseases including coronary artery disease, heart failure, stroke and vascular dementia are diseases of the vasculature. In addition vascular injury underpins conditions like kidney failure and cardiovascular complications of diabetes. This field is truly multidisciplinary involving scientists in many domains such as molecular and vascular biology, cardiovascular physiology and pharmacology and immunology and inflammation. Clinically, specialists across multiple disciplines are involved in the management of patients with vascular disorders, including cardiologists, nephrologists, endocrinologists, neurologists and vascular surgeons. This book covers a wide range of topics and provides an overview of the discipline of vascular biomedicine without aiming at in-depth reviews, but rather offering up-to-date knowledge organized in concise and structured chapters, with key points and pertinent references. The structure of the content provides an integrative and translational approach from basic science (e.g. stem cells) to clinical medicine (e.g. cardiovascular disease). The content of this book is targeted to those who are new in the field of vascular biology and vascular medicine and is ideal for medical students, graduate and postgraduate students, clinical fellows and academic clinicians with an interest in the vascular biology and physiology of cardiovascular disease and related pathologies. -- Provided by publisher.

Summary: "More women (47.6%) receive mental health services compared with men (34.8%). Women are twice as likely as men to develop major depressive disorder. Furthermore, 10%-15% of women experience depression during the perinatal period, which makes depression one of the most common complications of childbirth (Gaynes et al. 2005). These statistics illustrate that psychiatric disorders in women are common during the reproductive years and that the hormonal fluctuations associated with the reproductive life cycle contribute to the etiology of mental illness in women. Medical practitioners in all fields will encounter female patients with mental illness across the lifespan, particularly major depressive and anxiety disorders. Consequently, there is a great imperative for high-quality educational materials that increase the competency of providers. This outstanding work is divided into two parts. Part I provides a comprehensive overview of the reproductive life cycle and covers mental health concerns across the lifespan, including the relationship between gynecological and sexual health and mental health as well as infertility, the premenstrual period, and perimenopause. Part II is devoted to the perinatal period and offers a conceptual framework for a clinical approach to the pregnant and postpartum patient, followed by evidence-based reviews of the management of psychiatric disorders (by diagnostic category), as well as covering stress in pregnancy, infant mental health, and legal/forensic issues. Critical summaries of the epidemiology, risk factors, screening methods, and clinical features are presented. This book must be required reading for all faculty and trainees who will care for women"-- Provided by publisher.

Contents:
The Reproductive Life Cycle / Alexis Lighten Wesley, Mira Zein, Melisa Olgun, Lisa A. Catapano
Gynecological Conditions and Mental Health / Brittney Bastow, Pooja Lakshmin
Female Sexual Dysfunctions and Reproductive Psychiatry / Erika Kelley, Brittney Bastow, Pooja Lakshmin, Sheryl A. Kingsberg
Contraception Implications for Mental Health / Lulu Zhao
Infertility and Perinatal Loss / Neha S. Hudepohl, Jessica L. Coker, Sharvari P. Shivanekar, Madhavi-Latha Nagalla, Soudabeh Givrad, Lindsay R. Standeven, Courtney Erdly, Premala Jones, Katherine E. Williams
Premenstrual Mood Syndromes / Erin Murphy Barzilay, Katherine Unverferth, Laura Obler
Perimenopause / Nicole Leistikow, Milena H. Smith, Katherine E. Williams, C. Neill Epperson
A Clinical Approach to Psychiatric Diagnosis and Treatment During Pregnancy / Elizabeth M. Fitelson, Lauren M. Osborne, Jennifer L. Payne
A Clinical Approach to Psychiatric Diagnosis and Treatment in the Postpartum Period / Alyson Gorun, Mira Zein, Melisa Olgun, Lisa A. Catapano
A Treatment Approach to Psychiatric Emergencies in the Perinatal Period / Jovana Martinovic, Pooja Lakshmin, Mira Zein, Melisa Olgun, Lucy A. Hutner
Stress in Pregnancy : Impacts on Mother and Child / Lea Takács, Vanessa Babineau, Catherine Monk
Infant Mental Health and the Parent-Infant Relationship : Essentials, Assessment, and Treatment / Soudabeh Givrad, Jennifer J. Paul, Christine Wittmann, Mireya Nadal-Vicens, Celeste St. John-Larkin
Depressive Disorders / Lauren M. Osborne, Catherine Birndorf
Integrative Approaches to Perinatal Depression / Madeleine A. Becker, M. Camille Hoffman, Nina T. Ballone, Ripal Shah
Bipolar Disorder and Related Disorders / Sarah M. Nagle-Yang, Sarah A. DeBrunner, Andrea Favini, Andrew M. Novick, Caitlin Hasser, Chandni Prakash, Margo Nathan
Postpartum Psychosis / Caitlin Hasser, Jovana Martinovic, Pooja Lakshmin, Mira Zein, Melisa Olgun, Lucy A. Hutner, Sarah M. Nagle-Yang, Lauren M. Osborne
Schizophrenia and Related Disorders / Sarah M. Nagle-Yang, Susan Hatters Friedman, Caitlin Hasser, Ashley Mulvihill, Andrew M. Novick, Allyce K. Jones, Eric Reed, Surya Sabhapathy
Trauma and Reproductive Health / Priya Gopalan, Elizabeth Albertini, Priyanka Amin, Maureen Curley, Jody Glance, Saira Kalia, Neeta Shenai
Anxiety Disorders and Insomnia in the Perinatal Period / Lucy A. Hutner, Joanna V. MacLean, Gioia M. Guerrieri, D.O., Melisa Olgun, Julia Frew
Obsessive-Compulsive Disorder / Neha S. Hudepohl, Nicole Leistikow, Mimi Levine, Lauren M. Osborne
Substance Use Disorders / Julia Frew, Lauren Augello, Marley Doyle, Constance Guille, Susan Karabell, Lulu Zhao
Eating Disorders / Robin Valpey, Jyoti Sachdeva, Joy E. Moel
Attention-Deficit/Hyperactivity Disorder / Lucy A. Hutner, Jaina Amin, Jeanne Coulehan, Madhumathi Rao, Melisa Olgun, Mimi Levine
Forensic Issues in Perinatal Psychiatry / Susan Hatters Friedman, Aimee Kaempf, Jacqueline Landess, Sarah M. Kauffman.

Contents:
Regulation of TGF-beta receptors / Erine H. Budi, Jian Xu, and Rik Derynck
2 Determining TGF-beta receptor levels in the cell membrane / Long Zhang ... [et al.]
Posttranslational modifications of TGF-beta receptors / Xiaohua Yan and Ye-Guang Chen
Production, isolation, and structural analysis of ligands and receptors of the TGF-beta superfamily / Tao Huang and Andrew P. Hinck
Phosphorylation of Smads by intracellular kinases / Fang Liu and Isao Matsuura
Analysis of Smad phosphatase activity in vitro / Tao Shen, Lan Qin, and Xia Lin
Three-dimensional mammary epithelial cell morphogenesis model for analysis of TGFbeta signaling / Juliet Rashidian and Kunxin Luo
TGF-beta signaling in stem cell regulation / Wenlin Li, Wanguo Wei, and Sheng Ding
Analysis of epithelial-mesenchymal transition induced by transforming growth factor beta / Ulrich Valcourt ... [et al.]
In vitro Th differentiation protocol / Takashi Sekiya and Akihiko Yoshimura
Interrogating TGF-beta function and regulation in endothelial cells / J. A. Maring ... [et al.]
Isolation and manipulation of adipogenic cells to assess TGF-beta superfamily functions / Maria Namwanje, Juan C. Bournat, and Chester W. Brown
Imaging TGF-beta signaling in mouse models of cancer metastasis / Yibin Kang
Generation and characterization of Smad7 conditional knockout mice / Yi Pan and Yan Chen
Monitoring Smad activity in vivo using the Xenopus model system / Marco Montagner, Graziano Martello, and Stefano Piccolo
Animal cap assay for TGF-beta signaling / Chenbei Chang
Detection of Smad signaling in Zebrafish embryos / Xingfeng Liu, Qiang Wang, and Anming Meng
Role of TGF-beta signaling in coupling bone remodeling / Janet L. Crane, Lingling Xian, and Xu Cao
Studying the functions of TGF-beta signaling in the ovary / Chao Yu, Jian-Jie Zhou, and Heng-Yu Fan
Quantitative real-time PCR analysis of MicroRNAs and their precursors regulated by TGF-beta signaling / Hara Kang and Akiko Hata
TGF-beta-regulated MicroRNAs and their function in cancer biology / Pengyuan Yang ... [et al.]
Epigenomic regulation of Smad1 signaling during cellular senescence induced by Ras activation / Atsushi Kaneda ... [et al.]
Role of ubiquitination to Determine non-Smad signaling responses / Shyam Kumar Gudey and Marene Landström
Genome-wide RNAi screening to dissect the TGF-beta signal transduction pathway / Xiaochu Chen and Lan Xu
Measuring TGF-beta ligand dynamics in culture medium / Zipei Feng , Zhike Zi , and Xuedong Liu.

Summary: Drawing on ten years of working with businesses, nonprofits, governments, and families, the authors combine the latest insights from neuroscience and psychology with practical advice to explain how to turn feedback into productive listening and learning. "The bestselling authors of the classic Difficult Conversations teach us how to turn evaluations, advice, criticisms, and coaching into productive listening and learning We swim in an ocean of feedback. Bosses, colleagues, customers-but also family, friends, and in-laws-they all have "suggestions" for our performance, parenting, or appearance. We know that feedback is essential for healthy relationships and professional development-but we dread it and often dismiss it. That's because receiving feedback sits at the junction of two conflicting human desires. We do want to learn and grow. And we also want to be accepted just as we are right now. Thanks for the Feedback is the first book to address this tension head on. It explains why getting feedback is so crucial yet so challenging, and offers a powerful framework to help us take on life's blizzard of off-hand comments, annual evaluations, and unsolicited advice with curiosity and grace. The business world spends billions of dollars and millions of hours each year teaching people how to give feedback more effectively. Stone and Heen argue that we've got it backwards and show us why the smart money is on educating receivers- in the workplace and in personal relationships as well. Coauthors of the international bestseller Difficult Conversations, Stone and Heen have spent the last ten years working with businesses, nonprofits, governments, and families to determine what helps us learn and what gets in our way. With humor and clarity, they blend the latest insights from neuroscience and psychology with practical, hard-headed advice. The book is destined to become a classic in the world of leadership, organizational behavior, and education"-- Provided by publisher.

Contents:
The feedback challenge. Three triggers
Truth triggers. Separate appreciation, coaching, and evaluation
First understand
See your blind spots
Relationship triggers. Don't switchtrack
Identify the relationship system
Identity triggers. Learn how wiring and temperament affect your story
Dismantle distortions
Cultivate a growth identity
Feedback in conversation. How good do I have to be?
Navigate the conversation
Get going
Pull together.

Contents:
Pterygium : history and overview / Arun C. Gulani and Parth G. Patel
Classic signs, symptoms, classification, and differential diagnosis of pterygium / Sotiria Palioura and Eduardo Alfonso
Current concepts in treatments of pterygium : an evidence-based review / Nathan Rock, Ming Wang, Nancy Argano, and Ilan Cohen
Evolution of the medical and surgical treatments for pterygium / Ahmed A. Abdelghany and Jorge L. Alio
Ocular surface and tear film management in pterygium surgery / Alanna S. Nattis, Henry D. Perry, and Eric D. Donnenfeld
Amniotic membrane and umbilical cord as platform technology to promote regenerative healing / Anny M.S. Cheng and Scheffer C.G. Tseng
Conjunctival autograft for primary and recurrent pterygium : past, present, and future / Minas T. Coroneo
Amniotic graft surgery in ocular surface pathologies besides pterygium / Arun C. Gulani
Mitomycin C, glues, sealants, and ancillaries in pterygium surgery / Arun C. Gulani, and Sonal Tuli
Nonsurgical management of irregular astigmatism associated with pterygium / Melissa Barnett, Thomas P. Arnold, Nathan Schramm, Andrew Morgenstein, Christine Sindt, and Tracy Schroeder Swartz
Stem cell applications in pterygium / Abhinav Loomba and Virender Singh Sangwan
Surgical approach to isolated and associated presentations of pterygium / Alan N. Carlson
Complications of pterygium surgery / Dhivya Ashok Kumar, Soosan Jacob, Ashvin Agarwal, and Amar Agarwal
Complex pterygium surgery and complication management to cosmetic endpoints / Arun C. Gulani and Aaishwariya A. Gulani
Pterygium and pinguecula surgery : next-day cosmetic outcomes / Arun C. Gulani and Aaishwariya A. Gulani
Kerato-refractive and premium cataract surgery with pterygium / Arun C. Gulani.

Summary: Updated to include details about key legislation that affects budgeting, The Nurse Manager's Guide to Budgeting and Finance, 3rd Edition, provides practical tools, tips, and strategies for running a unit that were not taught in nursing school. -- Provided by publisher.

Contents:
Front cover
Back cover
Endorsements
Title page
Copyright page
Dedication
Acknowledgments
About the author
Table of contents
Foreword
Introduction
Chapter 1. Budgeting for the nurse manager
Chapter 2. Healthcare reimbursement
Chapter 3. Budget types
Chapter 4. Budget development
Chapter 5. Operating budgets
Chapter 6. Capital budgets
Chapter 7. Budget variances
Chapter 8. Budget reports
Chapter 9. Healthcare reform and the Affordable Care Act
Chapter 10. Governing boards of healthcare organizations and specialty nursing organizations
Chapter 11. Improving quality and safety to increase reimbursement
Chapter 12. Conclusions
Index.

Summary: "Developed and adapted by the authors of this book, thematic analysis (TA) is one of the most popular qualitative data analytic techniques in psychology and the social and health sciences. Building on the success of Braun & Clarke's 2006 paper first outlining their approach which has over 100,000 citations on Google Scholar - this book is the definitive guide to TA and your support system throughout your TA journeys. It addresses the common questions surrounding TA as well as developments in the field, offering a highly accessible and practical discussion of doing TA situated within a clear understanding of the wider terrain of qualitative research."-- Back cover.

Contents:
Section 1: Venturing forth! Doing reflexive thematic analysis
1 It's almost time to depart: Getting ready for your thematic analysis adventure
2 Taking an initial lay of the land: Introducing our worked example dataset and doing familiarisation
3 Exploring this world in detail: Doing coding
4 Finding, losing, then finding your way again: Developing your themes
5 Arriving home and telling a story about your adventure: Writing your thematic analysis report
Section 2: Going deeper for tip-top reflexive thematic analysis: Theory, interpretation, and quality matters
6 A not-so-scary theory chapter: Conceptually locating reflexive thematic analysis
7 So what? The importance of interpretation in reflexive thematic analysis
8 One big happy family? Understanding similarities and differences between reflexive TA and its methodological siblings and cousins
9 Getting your own house in order: Understanding what makes good reflexive thematic analysis to ensure quality
Fare-well!

Summary: "This unifying volume offers a clear theoretical framework for the research shaping the emerging direction of informatics in health care. Contributors ground the reader in the basics of informatics methodology and design, including creating salient research questions, and explore the human dimensions of informatics in studies detailing how patients perceive, respond to, and use health data. Real-world examples bridge the theoretical and the practical as knowledge management-based solutions are applied to pervasive issues in information technologies and service delivery. Together, these articles illustrate the scope of health possibilities for informatics, from patient care management to hospital administration, from improving patient satisfaction to expanding the parameters of practice. Highlights of the coverage: · Design science research opportunities in health care · IS/IT governance in health care: an integrative model · Persuasive technologies and behavior modification through technology: design of a mobile application for behavior change · The development of a hospital secure messaging and communication platform: a conceptualization · The development of intelligent patient-centric systems for health care · An investigation on integrating Eastern and Western medicine with informatics Interest in Theories to Inform Superior Health Informatics Research and Practice cuts across academia and the healthcare industry. Its audience includes healthcare professionals, physicians and other clinicians, practicing informaticians, hospital administrators, IT departments, managers, and management consultants, as well as scholars, researchers, and students in health informatics and public health"--Back cover.

Summary: This book highlights the importance of understanding gastric and colon cancer metabolism in guiding diagnosis and drug discovery. It summarizes the correlation between adiponectin and matrix metalloproteinase with colorectal cancer. The book also evaluates the divergent role of hypoxia-inducible factor 1 in colorectal cancer growth and metastasis. After discussing the role of genetic polymorphisms in alcohol metabolizing enzymes and EPHX1 with the onset of colorectal cancer, it reviews the molecular mechanisms of chemoresistance in gastric cancer and novel therapeutic strategies to reverse the chemoresistance of tumors. In addition, the book explores the theranostic role of nanoparticles and therapeutic potential of phytochemicals with regard to colorectal cancer. Given its scope, the book offers a valuable guide for oncologists, academic researchers, pharmaceuticals practitioners, and students who are involved in research and treatment of cancer. -- Provided by publisher.

Contents:
Chapter 1. Therapeutic role of Phytochemicals in Colorectal cancer
Chapter 2. Adiponectin Signaling In Colorectal Cancer
Chapter 3. Role of Matrix Metalloproteinases in Colorectal Cancer
Chapter 4. The Role of Hypoxia-Inducible Factor 1- Alpha in Colorectal Cancer
Chapter 5. Mechanisms and pathways of metabolic reprogramming of colorectal cancer
Chapter 6. Targeting metabolic reprogramming of colorectal cancer
Chapter 7. Understanding colorectal cancer: the basics
Chapter 8. Molecular signaling pathways involved in gastric cancer chemoresistance
Chapter 9. Meta-analysis reveals no significant association of EPHX1 Tyr113His and His139Arg polymorphisms with the colorectal cancer risk
Chapter 10. Meta-analysis of genetic variants in alcohol metabolizing enzymes and their association with colorectal cancer risk
Chapter 11. Gut microbiota as signatures in non-communicable diseases and mucosal immunity
Chapter 12. Immunotherapy for Colon Cancer: Recent Perspectives
Chapter 13. Nanotechnology Applications in Gastric cancer. .

Summary: The book discusses recent findings and current perspectives on therapeutic angiogenesis. Studies have shown that therapies such as cell implantation and transfer of gene encoding for angiogenic growth factors are effective in improving symptoms in patients with critical limb ischemia, who previously had no treatment option other than amputation. The book discusses these therapies and presents data collected in clinical studies over the past decade. Despite significant advances in therapeutic angiogenesis since the first clinical studies in the early 21st century, it has been largely ignored in the literature. This comprehensive book fills that gap, making it a valuable resource for both researchers and practitioners alike.

Contents:
Identification of regulatory RNA in bacterial genomes by genome-scale mapping of transcription start sites
Screening inhibitory potential of anti-HIV RT RNA aptamers
Design and evaluation of clinically relevant SOFA-HDV ribozymes targeting HIV RNA
Directing RNase P-mediated cleavage of target mRNAs by engineered external guide sequences in cultured cells
Design and analysis of hammerhead ribozyme activity against an artificial gene target
Knockdown strategies for the study of proprotein convertases and proliferation in prostate cancer cells
Use of tumor-targeting trans-splicing ribozyme for cancer treatment
Characterization of hairpin ribozyme reactions
Finding instances of riboswitches and ribozymes by homology search of structured RNA with infernal
Structure-based virtual screening for the identification of RNA- binding ligands
Probing riboswitch binding sites with molecular docking, focused libraries, and in-line probing assays
Discovery of small molecule modifiers of micrornas for the treatment of HCV infection
Bacterial flavin mononucleotide riboswitches as targets for flavin analogs
Construction and application of riboswitch-based sensors that detect metabolites within bacterial cells
Screening assays to identify artificial glmS ribozyme activators
Analysis of riboswitch structure and ligand binding using small-angle X-ray scattering (SAXS)
Use of SHAPE to select 2AP substitution sites for RNA-ligand interactions and dynamics studies
Cell internalization SELEX: In vitro selection for molecules that internalize into cells
DNA electronic switches based on analyte-responsive aptamers.

Contents:
Overview of the indications for embolizations
Materials used for embolization
Bronchial artery embolization for massive hemoptysis
Renal artery embolization for bleeding, hemangiomas, renal cell carcinoma
Splenic artery embolization for non-surgical splenectomy
Embolization of arterio-venous malformations
Uterine artery embolization for intractable menorrhagia.

Summary: This book provides an up-to-date review of therapeutic EUS with an equal focus on technical descriptions with ample endoscopic images/video clips by world experts and the scientific evidence behind the described techniques. The book provides an overview of the field in a structured manner, starting with general topics on equipment and service development and extending to the fields of EUS-guided drainage, anti-tumor therapies, and other specific EUS-guided interventional treatments. Therapeutic Endoscopic Ultrasound is a key resource for endoscopists, gastroenterologists, surgeons, and GI oncologists.

Summary: This edited work presents studies that clarify several aspects of the development and application of therapeutic enzymes. Therapeutic enzymes exhibit fascinating features and opportunities, and represent a significant and promising subcategory of modern biopharmaceuticals for the treatment of several severe diseases. Research and drug developments efforts and the advancements in biotechnology over the past twenty years have greatly assisted the introduction of efficient and safe enzyme-based therapies for a range of both rare and common disorders. The introduction and regulatory approval of twenty different recombinant enzymes has enabled effective enzyme-replacement therapy. This book covers mainly three areas of recombinant therapeutic enzymes and their clinical and pharmaceutical technology: (i) overview of the production process and biochemical characterization of therapeutic enzymes, (ii) focuses upon the engineering strategies and delivery methods of therapeutic enzymes, (iii) clinical applications of selected therapeutic enzymes, including aspects on their mechanisms of action and information on safety, immunogenicity issues and various adverse events of the enzymes used for therapy. The topic of this book is particularly relevant to academics, researchers and students undertaking advanced undergraduate/postgraduate programs in the biopharmaceutical/biotechnology area who wish to gain a comprehensive understanding of enzyme-based therapeutic molecules.

Contents:
Chapter 1. Introduction to therapeutic enzymes
Chapter 2. Upstream processing technologies
Chapter 3. Downstream processing technologies
Chapter 4. Enzyme Manufacturing Process and Quality Control Evaluations
Chapter 5. Regulatory guidance in the production of therapeutic enzymes
Chapter 6. Biophysical methods for the characterization of Enzyme Therapeutics Bertrand Raynal Patrick England
Chapter 7. Clinical Development of a therapeutic enzyme
Chapter 8. Chemical modifications of therapeutic proteins
Chapter 9. Formulation of therapeutic enzymes
Chapter 10. Engineering of therapeutic enzymes for improving activity
Chapter 11. Engineering of therapeutic enzymes for improving stability
Chapter 12. Design and engineering of deimmunized therapeutic enzymes
Chapter 13. Nanoparticles for delivery of therapeutic enzymes
Chapter 14. Targeted delivery of therapeutic enzymes
Chapter 15. Oral and inhalable enzyme therapies
Chapter 16. Regulatory issues
Chapter 17. Enzyme replacement therapies
Chapter 18. Pharmacodynamics and pharmacokinetics issues of enzyme replacement therapy
Chapter 19. Enzyme therapy for lysosomal storage disorders
Chapter 20. Enzyme therapy for myocardial infarction
Chapter 21. Enzyme therapy for chronic gout
Chapter 22. Enzyme therapy for tumor lysis syndrome
Chapter 23. Enzyme therapy for collagen-based disorders
Chapter 24. Enzyme therapy for severe combined immunodeficiency disease
Chapter 25. Enzyme therapy for detoxification of methotrexate
Chapter 26. Enzyme therapy vitreomacular adhesion
Chapter 27. L-Asparaginase as anticancer agent
Chapter 28. Pancreatic enzyme replacement therapy
Chapter 29. Enzymes in metabolic anticancer therapy
Chapter 30. L-Arginase for L-Arg depletion therapy in cancer
Chapter 31. Methionine L-lyase for L-Met depletion therapy in cancer
Chapter 32. Enzyme therapy for celiac sprue
Chapter 33. Acid ceramidase
Chapter 34. Lysoso mal acid lipase
Chapter 35. Alkaline phosphatase and hypophosphatasia
Chapter 36. Enzybiotics: Antibiotic enzymes as drugs and therapeutics
Chapter 37. Anti-inflammatory enzymes
Chapter 38. Phenylalanine ammonia lyase for the treatment of phenylketonuria
Chapter 39. Clinical applications of Hyaluronidase
Chapter 40. Superoxide dismutase and oxidative stress modulation
Chapter 41. Organophosphate hydrolases as catalytic bioscavengers
Chapter 42. Novel therapeutic proteases
Chapter 43. Genome-editing enzymes
Chapter 44. Gene therapy for enzyme deficiency: current status and future prospects.

Summary: This atlas, featuring a wealth of high-quality images, offers a comprehensive overview of therapeutic gastrointestinal endoscopy for upper and lower gastrointestinal diseases. Both established and new therapeutic techniques using advanced endoscopic devices are extensively covered. The concise text accompanying the endoscopic photographs and illustrations will enable readers to understand the details of each procedure. Special tips of practical value are highlighted and potential pitfalls, identified. The authors are experts in the field who have a great store of knowledge on a wide variety of therapeutic endoscopic procedures. Gastrointestinal endoscopy is the principal tool for the investigation and treatment of most diseases of the gastrointestinal tract. This book will provide the clear guidance that practitioners require in order to perform therapeutic gastrointestinal endoscopy optimally; it will prove indispensable for all gastrointestinal endoscopists.

Contents:
1. Endoscopic treatment for esophageal varices
2. Endoscopic treatment for gastric varices
3. Endoscopic treatment for nonvariceal upper GI bleeding
4. Endoscopic treatment for lower GI bleeding
5. Endoscopic mucosal resection for upper GI neoplasia
6. Endoscopic submucosal dissection for esophageal neoplasia
7. Endoscopic submucosal dissection for gastric neoplasia
8. Colonoscopic polypectomy
9. Endoscopic submucosal dissection for colorectal neoplasia
10. Ablation therapy for gastrointestinal neoplasia
11. Endoscopic treatment for Achalasia
12. Endoscopic dilation of esophageal strictures
13. Stent placement for malignant esophageal obstruction
14. Endoscopic dilation and stenting for pyloric strictures
15. Endoscopic dilation and stenting for colorectal stricture
16. Percutaneous endoscopic gastrostomy
17. Enteral tube placement
18. Endoscopic treatment of gastrointestinal leaks
19. Removal of gastrointestinal foreign bodies
20. Therapeutic small bowel endoscopy
21. Therapeutic endoscopic ultrasonography.

Summary: The second edition of this atlas has been extensively revised to provide an up-to-date and comprehensive overview of therapeutic gastrointestinal endoscopy for upper and lower gastrointestinal diseases. The coverage ranges from basic but highly effective procedures like cold snare polypectomy and variceal ligation to sophisticated procedures such as peroral endoscopic myotomy and endoscopic submucosal dissection. New instruments, for example over-the-scope clips and various stents, are introduced in the relevant chapters. Furthermore, several chapters have been added to cover cutting-edge technologies for endoscopic treatment of complex conditions, including refractory gastroesophageal reflux disease and duodenal neoplasia. Many pictures have been exchanged for newer ones, most of them high-definition endoscopy photos, and schematic illustrations are used to ensure clear understanding of complex therapeutic procedures. As in the first edition, special tips of practical value are highlighted and potential pitfalls are identified, but in addition instructive cases have been added at the end of chapters. The second edition of Therapeutic Gastrointestinal Endoscopy will be an essential resource for all therapeutic endoscopists.

Contents:
1. Endoscopic treatment for esophageal varices
2. Endoscopic treatment for gastric varices
3. Endoscopic treatment for nonvariceal upper GI bleeding
4. Endoscopic treatment for lower gastrointestinal bleeding
5. Removal of gastrointestinal foreign bodies
6. Endoscopic mucosal resection for upper GI neoplasia
7. Endoscopic submucosal dissection for esophageal neoplasia
8. Endoscopic submucosal dissection for gastric neoplasia
9. Endoscopic management of non-ampullary duodenal neoplasia
10. Colonoscopic polypectomy
11. Endoscopic submucosal dissection for colorectal neoplasia
12. Ablation therapy for gastrointestinal neoplasia
13. Endoscopic treatment of GI subepithelial tumors
14. Endoscopic dilation of esophageal strictures
15. Stent placement for malignant esophageal obstruction
16. Endoscopic management for pyloric stricture : dilation, stenting, and pyloromyotomy (G-POEM)
17. Endoscopic treatment for Achalasia
18. Endoscopic dilation and stenting for colorectal stricture
19. Percutaneous endoscopic gastrostomy
20. Endoscopic treatment for gastrointestinal perforation and leakage
21. Therapeutic small bowel endoscopy
22. EUS-guided sampling for subepithelial tumors
23. Endoscopic treatment of refractory gastroesophageal reflux disease.

Summary: The blood-brain-barrier prevented harmful materials entering the brain and in the meantime is a barricade to therapeutic drug delivery. Intranasal drug delivery to circumvent blood-brain-barrier was developed in the past, to take advantages of a secret passage from the olfactory epithelium into the brain-bypassing the tight junctions that encapsulated the brain from blood circulation. This timely publication of Therapeutic Intranasal Delivery for Stroke and Neurological Disorders presented some of the latest advances in intranasal delivery research, including transnasal hypothermia induction, stem cell intranasal transplantation, intranasal drug delivery in ischemic and hemorrhagic models, intranasal peptides delivery, intranasal tPA application in adults and children. Editors Jun Chen, Jian Wang, Ling Wei and John Zhang are professors from University of Pittsburgh, Johns Hopkins University, Emory University and Loma Linda University in USA.

Contents:
Preface
Transnasal Induction of Therapeutic Hypothermia for Neuroprotection
Hypoxia-Primed Stem Cell Transplantation in Stroke
Therapeutic potential of intranasal drug delivery in preclinical studies of ischemic stroke and intracerebral hemorrhage
Intranasal Drug Delivery after Intracerebral Hemorrhage
Intranasal Treatment in Subarachnoid Hemorrhage
Intranasal Delivery of Therapeutic Peptides for Treatment of Ischemic Brain Injury
Intranasal delivering method in the treatment of ischemic stroke
Intranasal Delivery of Drugs for Ischemic Stroke Treatment: Targeting IL-17A
Intranasal tPA application for axonal remodeling in rodent stroke and traumatic brain injury models
Therapeutic Intranasal Delivery for Alzheimer's disease
Combination therapy of intranasal IGF-1 and hypothermia
Intranasal Medication Delivery in Children for Brain Disorders
Index.

Summary: The second edition of this important book provides an up-to-date and comprehensive overview of clinical lipidology. Brand new chapters focus on recent advances in the field including novel biomarkers and the microbiome, genomics of cardiovascular risks, PCSK9 inhibitors, imaging technologies, and epidemiology of atherosclerotic cardiovascular disease. The book describes new guidelines, novel therapeutic agents, and changes in the understanding of specific lipoproteins and subclasses with regard to their relationships to cardiovascular disease risk. The second edition contains more than thirty chapters covering such topics as the history of lipidology, lipoprotein metabolism and vascular biology, disorders of lipid metabolism, lifestyle/dietary and pharmacologic management for dyslipidemia, the management of dyslipidemia in certain subgroups (e.g., women, children, older patients) and lipid testing, as well as an examination of other biomarkers and testing procedures related to atherosclerosis and cardiovascular disease. The second edition of Therapeutic Lipidology is an essential resource for physicians, medical students, residents, fellows, and allied health professionals in lipidology, cardiology, endocrinology, pharmacotherapy, and health promotion and disease prevention.

Summary: "Therapeutic Modalities in Rehabilitation is a theoretically based but practically orientated guide to the use of therapeutic modalities for practicing clinicians and their students. It clearly presents the basis for use of each different type of modality and allows clinicians to make their own decision as to which will be the most effective in a given situation. Present in full color, the text describes various concepts, principles, and theories that are supported by scientific research, factual evidence, and experience of the authors in dealing with various conditions."

Contents:
Part 1. Foundations of therapeutic modalities. The basic science of therapeutic modalities
Using therapeutic modalities to affect the healing process
The role of therapeutic modalities in wound healing
Managing pain with therapeutic modalities
Part 2. Electrical energy modalities. Basic principles of electricity and electrical stimulating currents
Iontophoresis
Biofeedback
Principles of electrophysiologic evaluation and testing
Part 3. Thermal energy modalities. Cryotherapy and thermotherapy
Part 4. Sound energy modalities. Therapeutic ultrasound
Extracorporeal shockwave therapy
Part 5. Electromagnetic energy modalities. Shortwave and microwave diathermy
Light therapy
Part 6. Mechanical energy modalities. Spinal traction
Intermittent pneumatic compression devices
Therapeutic massage
Vibration therapy.

Summary: "The sixth edition of Therapeutic Modalities in Rehabilitation will attempt to present the basic science and the current best available evidence from systematic reviews for each different type of modality and allow the clinician to make his or her own decision as to which will be most effective in a given situation to achieve optimal patient outcomes. Some recommended protocols developed through the experiences of the contributing authors will be presented"-- Preface

Contents:
The Basic Science of Therapeutic Modalities
Using Therapeutic Modalities to Affect the Healing Process
The Role of Therapeutic Modalities in Wound Healing
Managing Pain with Therapeutic Modalities
Basic Principles of Electricity and Electrical Stimulating Currents
Iontophoresis
Biofeedback
Principles of Electrophysiologic Evaluation and Testing
Cryotherapy and Thermotherapy
Therapeutic Ultrasound
Extracorporeal Shock Wave Therapy
Shortwave and Microwave Diathermy
Photobiomodulation Therapy
Spinal Traction
Intermittent Pneumatic Compression Devices
Therapeutic Massage and Soft Tissue Mobilization
Vibration Therapy
Appendix A: Location of Motor Points
Appendix B: Units of Measure
Answers to Self-Test Questions.

Summary: The recent revolution in molecular biology offers exciting new opportunities for targeted radionuclide therapy. The selective irradiation of tumor cells through molecular biological mechanisms is now permitting the radiopharmaceutical control of tumors that are unresectable and unresponsive to either chemotherapy or conventional radiotherapy. In this up-to-date, comprehensive book, world-renowned experts discuss the basic principles of radionuclide therapy, explore in detail the available treatments, explain the regulatory requirements, and examine likely future developments. The full range of clinical applications is considered, including thyroid cancer, hematological malignancies, brain tumors, liver cancer, bone and joint disease, and neuroendocrine tumors. The combination of theoretical background and practical information will provide the reader with all the knowledge required to administer radionuclide therapy safely and effectively in the individual patient. Careful attention is also paid to the important role of the therapeutic nuclear physician in delivering the effective coordination of a diverse multidisciplinary team that is essential to the safe provision of treatment.

Contents:
PART I: Basic Principles (11 chapters)
PART II: Clinical Applications: Brain and Nasopharyngeal Tumors (4 chapters).-Thyroid Cancer (11 chapters)
Benign Thyroid Diseases (2 chapters)
Primary and Metastatic Liver Cancer (5 chapters)
Bone and Joint Disease (5 chapters)
Hematological Malignancies (8 chapters)
Endocrine Tumors (2 chapters)
Radioimmunotherapy (7 chapters)
Intravascular/Intracavitary/Interstitial and Epidemal RadionuclideTherapy (5 chapters)
PART III: Radiation Biology and Dosimetry (11 chapters)
PART IV: Radiation Planning and Perspectives of Radionuclide Therapy (10 chapters)
Subject Index.

Contents:
Design of phage-displayed cystine-stabilized mini-protein libraries for proteinaceous binder engineering / Hung-Ju Chang and An-Suei Yang
Construction of a filamentous phage display peptide library / Annette Fagerlund, Astrid Hilde Myrset, and Mari Ann Kulseth
Engineering bioactive peptide-based therapeutic molecules / Jong Sang Ryu [and three others]
T7 lytic phage-displayed peptide libraries : construction and diversity characterization / Lauren R.H. Krumpe and Toshiyuki Mori
Affinity selection using filamentous phage display / Mari Ann Kulseth, Annette Fagerlund, and Astrid Hilde Myrset
Bioprospecting open reading frames for peptide effectors / Ling Xiong and Charles Scott
Identification of ideal peptides for heterovalent ligands / Ajay Shrivastava [and three others]
Substrate phage display for protease substrate sequence characterization : bovine factor Xa as a model system / Hung-Ju Hsu and An-Suei Yang
Engineering peptide therapeutics using MIMETIBODY [trademark] technology / Kristen Picha [and three others]
Evaluation of peptides as protease inhibitors and stimulators / Hannu Koistinen [and four others]
Assessment of antimicrobial (host defense) peptides as anti-cancer agents / Susan Douglas, David W. Hoskin, and Ashley L. Hilchie
Peptide labelling strategies for imaging agents / Tuulia Huhtal [and three others]
Peptide optimization and conjugation strategies in the development of molecularly targeted magnetic resonance imaging contrast agents / Andrew F. Kolodziej [and four others]
Evaluation of prenylated peptides for use in cellular imaging and biochemical analysis / Joshua D. Ochocki [and five others]
Ultraviolet absorption spectroscopy of peptides / Mangala R. Liyanage [and three others]
Fluorescence spectroscopy of peptides / Mangala R. Liyanage [and three others]
Circular dichroism of peptides / Kunal Bakshi [and three others]
Fourier transform infrared spectroscopy of peptides / Kunal Bakshi [and three others].

Summary: This book compiles updated research about the implications of therapeutic proteins in various human diseases. The initial chapters of the book provide basic information on the therapeutic proteins and discuss techniques for their formulation, production, and analytic approaches for their characterization. The subsequent chapters shed light on therapies based on therapeutic proteins against metabolic disorders, neurological disorders, cancer, autoimmune disorders, and infectious diseases. Importantly, it presents the factors influencing the immunogenicity of therapeutic proteins, including, genetic factors, disease type, and origin of therapeutic protein, dose frequency, administration route, and treatment duration. The book also reviews the strategies for reducing immunogenicity associated with therapeutic proteins, including PEGylation, site specific mutagenesis, exon shuffling, and humanizing of monoclonal antibodies. Further, it presents strategies for improving the typical drawback associated with protein therapeutics including instability and limited penetration through biological barriers. This book covers various computational methods that are commonly used for designing therapeutic proteins and in silico method for predicting and improving in vivo efficacy of the therapeutic molecules. Lastly, the book highlights the recent advances in developing nanosized delivery systems to improve safety and efficacy of protein therapeutics. This book caters to students and researchers of medicinal chemistry, pharmaceutical sciences and therapeutics. It is also useful to clinicians working with therapeutic proteins.

Contents:
Proteins drug targeting and its therapeutics
Interferons
Epidermal growth factor (egf) in wound repair
Therapeutic protein against autoimmune disorders: Intracellular and extracellular properties
Prions as Therapeutic proteins and their Prospect as Drug Delivery Agent
INTERLEUKIN - 2
Bioinformatics resources, tools, and strategies in designing therapeutic proteins
Therapeutic proteins used in human pancreatic disease
Therapeutic role of soybean-derived lunasin peptide in colon cancer treatment: A recent updates from literature
Therapeutic peptides in skin and hair disorders. .

Summary: This collection of research articles and reviews covers the latest work in the design, delivery, dynamic abilities, and immune stimulation of RNA nanoparticles which have driven the utilization of their immunomodulatory properties. The unknown immune properties of nucleic acid nanoparticles have been a major hurdle in their adaptation until the works herein began assessing their structure-activity relationships. This collection chronologically follows the path of investigating the recognition of design components to implementing them into nucleic acid nanostructures. RNA nanotechnology is an emerging platform for therapeutics with increasing clinical relevance as this approach becomes more widely used and approved for the treatment of various diseases. The latest research aims to take advantage of RNA's modular nature for the design of nanostructures which can interact with their environments to communicate programmed messages with intracellular pathways. In doing so, nanoparticles can be used to elicit or elude responses by the immune system as desired in conjunction with their therapeutic applications.

Contents:
Neurophysiology of rTMS
Brain imaging ? network effects of rTMS
Basic principles of rTMS in motor recovery after stroke
Clinical applications of rTMS in motor rehabilitaton after stroke
rTMS in dysphagia after stroke
Basic principles of rTMS in aphasia treatment after stroke
Therapeutic applications of rTMS for aphasia after stroke
rTMS in visual neglect after stroke
Clinical applications of rTMS in Parkinson?s disease
rTMS in the treatment of neuropathic pain
Therapeutic applications of rTMS for tinnitus
General concepts of therapeutic rTMS in neurology.

Contents:
Introduction to therapeutic and functional stretching
Functional and dysfunctional ROM
Causes of ROM loss and therapeutic potential of rehabilitation
Adaptation in ROM loss and recovery
Specificity in ROM rehabilitation
The overloading condition for recovery
Exposure and scheduling the ROM challenge
Rehabilitating the active ROM : neuromuscular rehabilitation
Pain management and ROM-desensitization
Stretch tolerance model
Psychological and behavioral considerations in ROM rehabilitation
Towards a functional approach
Demonstration of functional approach in ROM rehabilitation

Summary: "This unique book deals with both inflammation and cancer in a single source of publication. They are seldom grouped together although it has been known that both diseases are closely associated, particularly in the gastrointestinal tract and liver. As the book touches on two such major areas of diseases in humans, it should be of interest to a wider audience of researchers and readers. It is noted that the book combines the effort of both basic scientists and clinicians from different countries with extensive experiences in molecular biology and clinical practice to unveil the most updated picture of the pathogenesis and therapeutic strategies in the treatment of inflammation and cancer in the digestive tract. In this regard, potential pathogenic modulators and also therapeutic options are widely discussed. These types of information would definitely broaden our knowledge in better understanding these diseases."--Publisher's website.

Contents:
General introduction of inflammation and cancer in the digestive tract
Inflammation and therapeutics in the digestive tract
Carcinogenesis and therapeutic targets in the gastrointestinal tract
Autophagy and microRNAs as the therapeutic targets in gastrointestinal cancers.

Contents:
Part I
High Intensity Focused Ultrasound Ablation of Pathological Tissue
Chapter 1. HIFU Tissue Ablation: Concept & Devices G. Ter Haar
Chapter 2. Prostate Focused Ultrasound Therapy J.Y. Chapelon, O. Rouvière, S. Crouzet, A. Gelet
Chapter 3. MRI-guided HIFU Methods for the Ablation of Liver and Renal Cancers B.D. de Senneville, C. Moonen, M. Ries
Chapter 4. Magnetic Resonance-guided High Intensity Focused Ultrasound Ablation of Breast Cancer
F.M. Knuttel, M.A.A.J. van den Bosch
Chapter 5. HIFU for Palliative Treatment of Pancreatic Cancer
T.D. Khokhlova, J.H. Hwang
Chapter 6. MR-guided Transcranial Focused Ultrasound
J.F. Aubry, M. Tanter
Chapter 7. Focused Ultrasound & Lithotripsy
T. Ikeda, S. Yoshizawa, N. Koizumi, M. Mitsuishi, Y. Matsumoto
Chapter 8. Heat-based Tumor Ablation: Role of the Immune Response F. Wu
Part II
Drug and Gene Delivery using Bubble-assisted Ultrasound
Chapter 9. Droplets, Bubbles and Ultrasound Interactions O. Shpak, M. Verweij, N. de Jong, M. Versluis
Chapter 10. Sonoporation: Concept and Mechanisms A. Bouakaz, A. Zeghimi, A.A. Doinikov
Chapter 11. Design of Microbubbles for Gene/Drug Delivery T. Bettinger, F. Tranquart
Chapter 12. Co-administration of Microbubbles and Drugs in Ultrasound-assisted Drug Delivery: Comparison with Drug-carrying Particles R. Suzuki, A.L. Klibanov
Chapter 13. Drug-loaded Perfluorocarbon Nanodroplets for Ultrasound-mediated Drug delivery N. Rapoport
Chapter 14. Bubble-assisted Ultrasound: Application in Immunotherapy and Vaccination J.M. Escoffre, R. Deckers, C. Bos, C. Moonen
Chapter 15. Sonoporation: Application for Cancer Therapy
J. Qin, T.Y. Wang, J.K. Willmann
Chapter 16. Microbubble-assisted Ultrasound for Drug Delivery in the Brain and Central Nervous System A. Burgess, K. Hynynen
Chapter 17. Microbubbles & Ultrasoun: Therapeutic Applications in Diabetic Nephropathy W.J. Cao, P.N. Matkar, H.H. Chen, A. Mofid, H. Leong-Poi
Chapter 18. Drug and Gene Delivery using Sonoporation for Cardiovascular Disease J. Castle, S.B. Feinstein
Chapter 19. Sonothrombolysis K.B. Bader, G. Bouchoux, C.K. Holland
Part III- Other Ultrasound Therapy
Chapter 20. Ultrasound-mediated Polymeric Micelle Drug Delivery H. Xia, Y. Zhao, R. Tong
Chapter 21. Stimulation of Bone Repair with Ultrasound
F. Padilla, R. Puts, L. Vico, A. Guignadon, K. Raum
Chapter 22. Sonodynamic Therapy: Concept, Mechanism & Application to Cancer Treatment A.P. McHale, J.F. Callan, N. Nomikou, C. Fowley, B. Callen.

Summary: This book highlights the potential of low-intensity pulsed ultrasound, or LIPUS, to introduce a new era in dentistry by revolutionizing the approach to dental treatment and providing a cure for pathologic conditions long considered untreatable. Readers will find information on all aspects of LIPUS, from its mode of action and biologic mechanisms to the full range of emerging clinical applications. The role of LIPUS in promoting dental tissue repair and regeneration and in tissue engineering is fully explained in a series of chapters focusing on stimulation of cell metabolism in the dentocraniofacial region, bone healing, periodontal regeneration, the temporomandibular joint, pulp cell differentiation, the salivary glands, and orthodontics. The past two decades have witnessed numerous discoveries that have enhanced the scope for use of therapeutic ultrasound in dentistry. In summarizing the latest knowledge in this exciting field, the book will be of interest to dental surgeons, orthodontists, periodontists, and other practitioners.

Summary: This book presents a series of perspectives on the therapeutic potential of the ritual and clinical use of the Amazonian hallucinogenic brew ayahuasca in the treatment and management of various diseases and ailments, especially its role in psychological well-being and substance dependence. Biomedical and anthropological data on the use of ayahuasca for treating depression, PTSD, and substance dependence in different settings, such as indigenous contexts, neo-shamanic rituals, contemporary therapeutic circles, and in ayahuasca religions, in both South and North America, are presented and critiqued. Though multiple anecdotal reports on the therapeutic use of ayahuasca exist, there has been no systematic and dense reflection on the topic thus far. The book brings the therapeutic use of ayahuasca to a new level of public examination and academic debate. The texts in this volume stimulate discussion on methodological, ethical, and political aspects of research and will enhance the development of this emergent field of studies.

Contents:
Therapeutic Applications of Ayahuasca and Other Sacred Medicines / Michael J. Winkelman
The Therapeutic Potentials of Ayahuasca in the Treatment of Depression / Fernanda Palhano-Fontes, Joao C. Alchieri, Joao Paulo M. Oliveira, Bruno Lobao Soares [and 3 others]
Ayahuasca as a Candidate Therapy for PTSD / Jessica L. Nielson and Julie D. Megler
Moments of Insight, Healing, and Transformation: A Cognitive Phenomenological Analysis / Benny Shanon
Healing with Ayahuasca: Notes on Therapeutic Rituals and Effects in European Patients Treating Their Diseases / Janine Tatjana Schmid
Ayahuasca and the Treatment of Drug Addiction / José Carlos Bouso and Jordi Riba
Hypotheses Regarding Ayahuasca's Potential Mechanisms of Action in the Treatment of Addiction / James I. Prickett and Mitchell B. Liester
Therapist and Patient Perspectives on Ayahuasca-Assisted Treatment for Substance Dependence / Anja Loizaga-Velder and Armando Loizaga Pazzi
Effect of Santo Daime Membership on Substance Dependence / Beatriz Caiuby Labate, Rafael Guimarães dos Santos, Rick Strassman, Brian T. Anderson and Suely Mizumoto
Experience of Treatment with Ayahuasca for Drug Addiction in the Brazilian Amazon / Xavier Fernández and Josep María Fábregas
Assessment of the Psychotherapeutic Effects of Ritual Ayahuasca Use on Drug Dependency: A Pilot Study / Xavier Fernández, Rafael Guimarães dos Santos, Marta Cutchet, Sabela Fondevila [and 5 others]
Healing with Yagé: An Interview with Taita Juan Bautista Agreda Chindoy / Brian T. Anderson, Beatriz Caiuby Labate and Celina M. De Leon
Postscript--Psychedelics in Unlocking the Unconscious: From Cancer to Addiction / Gabor Maté.

Summary: This book elaborates on a whole new understanding of digestive endoscopy, the core of which is to treat quite a number of diseases using minimally invasive methods. Currently, the tunnel technique has been applied in the treatment of digestive early stage carcinomas, esophageal achalasia and submucosal tumors originating from muscularis propria. And this promising technique would surely be more widely used in the future. The main contents of this book include the history of the digestive endoscopic tunnel technique, the practical anatomy involved, operation steps, indications and contraindications, complications and possible future exploration fields. This book is well suited for doctors and surgeons performing digestive endoscopic therapies.

Contents:
1 Introduction
2 Prevention and Treatment of Tunnel Infection
3 Preoperative Preparation
4 Anesthesia management and monitoring during digestive endoscopic tunnelling
5 Establishment of standard submucosal tunnel
6 Endoscopic Submucosal Tunnel Dissection
7 Peroral endsoscopic myotomy
8 Gastric Peroral Endoscopic Myotomy (G-POEM)
9 Diverticulum Peroral Endoscopic Myotomy (D-POEM)
10 Submucosal tunneling endoscopic resection
11 Application of Digestive Endoscopic Tunneling Technique in Mediastinal and Abdominal Cavity
12 Future Disease-Centered Principles of Endoscopic Treatment.

Summary: "Now in a revised and updated third edition, this noted practitioner guide and text incorporates the latest knowledge about psychopharmacology and collaborative care. Therapists and counselors learn when and how to make medication referrals and how to address patients' questions about drug benefits, side effects, safety, and more. Organized around frequently encountered mental health disorders, the book explains how medications work (including what they can and cannot accomplish). Strategies for collaborating successfully with patients, their family members, and prescribers are discussed in detail. Written for optimal practical utility, the text features case examples, sample referral letters, checklists, and a glossary. Subject Areas/Key Words: MSW programs, textbooks, mental health and social work professionals, medication assessments, handbook for nonprescribers, reference book, non-MDs, masters-level classes, psychotherapists, psychiatric drugs, psychotropics, referring clients, referrals Audience: Practitioners, graduate students, and instructors in clinical psychology, social work, counseling, and psychiatric nursing"-- Provided by publisher.

Contents:
How the brain works : a basic sketch
How psychotropic drugs work
Depression
Bipolar disorder
Anxiety disorders
Schizophrenia and other psychoses
Cognitive disorders
Alcoholism and substance abuse
Physical health and illness
Special populations
The therapeutic relationship
Effective referrals
Sharing care
Strengthening bonds.

Contents:
1. Overview of psoriasis / Michael Kelly-Sell and Johann E. Gudjonsson
2. Ultraviolet B phototherapy / Sandra Pena, Dane Hill, and Steven J. Feldman
3. Psoralen-ultraviolet light A therapy / Lauren M. Madigan and Henry W. Lim
4. Methotrexate / Vidhi V. Shah, Elaine J. Lin, Shivani P. Reddy, and Jashin J. Wu
5. Acitretin / Elaine J. Lin, Vidhi V. Shah, Shivani P. Reddy, and Jashin J. Wu
6. Cyclosporine / Vidhi V. Shah, Shivani P. Reddy, Elaine J. Lin, and Jashin J. Wu
7. Apremilast / Amit Om, Dane Hill, and Steven R. Feldman
8. Etanercept / Shivani P. Reddy, Vidhi V. Shah, Elaine J. Lin, and Jashin J. Wu
9. Infliximab / Catherine Ni, Shivani P. Reddy, and Jashin J. Wu
10. Adalimnumab / Shivani P. Reddy, Elaine J. Lin, Vidhi V. Shah, and Jashin J. Wu
11. Ustekinumab / John K. Nia and Mark G. Lebwohl
12. Secukinumab / Elaine J. Lin, Shivani P. Reddy, Vidhi V. Shah and Jashin J. Wu
13. Ixekizumab / Shivani P. Reddy, Vidhi V. Shah and Jashin J. Wu
14. Biosimilars / Shivani P. Reddy, Catherine Ni, and Jashin J. Wu
15. Combination therapies for psoriasis / Anjali S. Vekaria and Mark G. Lebwohl
16. Investigational therapies for psoriasis / Peter W. Hashim and Mark G. Lebwohl.

Contents:
Overview of Dermatologic Care in Children
Management of Skin Disorders of the Newborn
Atopic Dermatitis and Eczematous Eruptions
Psoriasis and Other Papulosquamous Skin Disorders
Hereditary Disorders of Cornification
Hereditary Disorders of the Dermis
Disorders of Hair and Nail
Disorders of the Sebaceous and Sweat Gland
Cutaneous Tumor and Tumor Syndromes
Histiocytosis and Malignancy
Disorders of Pigmentation
Vascular Disorders and Anomalies
Genodermatoses and Basement Membrane Zone Diseases
Infectious Diseases
Viral Disease and Exanthems of the Skin
Bites and Infestations
Hypersensitivity Syndromes
Photosensitivity and Photoreaction
Collagen Vascular Diseases
Inborn Metabolic Disorders and Endocrine Disorders
Cutaneous Manifestations of Systemic Disease
Cutaneous Manifestations of Psychologic Disorders and Management
Pearls for Pediatric Dermatologic Procedures
Light-Based Procedures in Pediatric Dermatology.

Contents:
Preface
Chapter 1: Why Social Medicine?
1.1: The Rise of Social Medicine
1.2: Human-being: Homo medicus
1.3: History of Drug
Chapter 2: What is a Social Medicine?
2.1: Concept of Social Medicine
2.2: Development of Social Medicine
2.3: Differentiation of Social Medicine
Chapter 3: Therapy of Social Medicine
3.1: Concept & Scope for Therapy of Social Medicine
3.2: Classification for Therapy of Social Medicine
Chapter 4: Pharmaco-gelotology
4.1: Introduction
4.2: Laughter Theory
4.3: Laughter Therapy
Chapter 5: Conclusion.

Summary: Presenting over 100 rehabilitation protocols for the hand and upper extremity in an easy-to-use, step-by-step format, this practical reference provides surgeons and therapists alike with a go-to source for the therapy technique or strategy appropriate for their patients. Covering injuries from the shoulder, elbow, wrist, hand and fingers, each protocol includes bullet-pointed steps in daily or weekly increments following the injury or surgery and are inherently adaptable to the specific surgical intervention or rehabilitation requirement. Procedures following arthroplasty, extensor and flexor tendon injuries, fractures and dislocations, ligament and soft tissue injures, and nerve compression syndromes are among the many and multifaceted therapies presented. This book will be an invaluable resource for the orthopedic surgeon, hand surgeon, physical therapist, occupational therapist, hand therapist and any active clinician treating injuries to the hand and upper extremity.

Contents:
Part I: Shoulder Arthroplasty
Part II: Shoulder Sports Injuries
Part III: Shoulder Trauma
Part IV: Elbow Nerve Injuries
Part V: Elbow Sports Injuries
Part VI: Elbow Trauma
Part VII: Wrist Bone Injuries
Part VIII: Wrist Ligament/Soft Tissue Injuries
Part IX: Wrist Nerve Injuries
Part X: Wrist Tendon Injuries
Part XI: Hand/Finger Bone Injuries
Part XII: Hand/Finger Nerve Injuries
Part XIII: Hand/Finger Soft Tissue/Ligament Injuries
Part XIV: Hand/Finger Tendon Injuries. .

Summary: "Not since Sherman Alexie's The Lone Ranger and Tonto Fistfight in Heaven and Louise Erdrich's Love Medicine has such a powerful and urgent Native American voice exploded onto the landscape of contemporary fiction. Tommy Orange's There There introduces a brilliant new author at the start of a major career. 'We all came to the powwow for different reasons. The messy, dangling threads of our lives got pulled into a braid--tied to the back of everything we'd been doing all along to get us here. There will be death and playing dead, there will be screams and unbearable silences, forever-silences, and a kind of time-travel, at the moment the gunshots start, when we look around and see ourselves as we are, in our regalia, and something in our blood will recoil then boil hot enough to burn through time and place and memory. We'll go back to where we came from, when we were people running from bullets at the end of that old world. The tragedy of it all will be unspeakable, that we've been fighting for decades to be recognized as a present-tense people, modern and relevant, only to die in the grass wearing feathers.' Jacquie Red Feather is newly sober and trying to make it back to the family she left behind in shame in Oakland. Dene Oxendene is pulling his life together after his uncle's death and has come to work the powwow and to honor his uncle's memory. Edwin Frank has come to find his true father. Bobby Big Medicine has come to drum the Grand Entry. Opal Viola Victoria Bear Shield has come to watch her nephew Orvil Red Feather; Orvil has taught himself Indian dance through YouTube videos, and he has come to the Big Oakland Powwow to dance in public for the very first time. Tony Loneman is a young Native American boy whose future seems destined to be as bleak as his past, and he has come to the Powwow with darker intentions--intentions that will destroy the lives of everyone in his path. Fierce, angry, funny, groundbreaking--Tommy Orange's first novel is a wondrous and shattering portrait of an America few of us have ever seen. There There is a multi-generational, relentlessly paced story about violence and recovery, hope and loss, identity and power, dislocation and communion, and the beauty and despair woven into the history of a nation and its people. A glorious, unforgettable debut"-- Publisher's description.

Summary: Thermophiles and hyperthermophiles exhibit great biotechnological potential, as they can be utilized in processes which require higher temperatures. This book comprehensively deals with all the aspects of thermophiles, starting from the source of these organisms to their latest applications. In addition it presents a compilation of all compounds produced by various thermophilic microorganisms. Due to their application in everyday life, the demands of enzymes that can work at higher temperature have been increasing. In order to keep pace with the increasing demand the industries have to search novel thermophiles producing their product of interest. Hence, this book will be of value for industries working on various biochemical products produced by these thermophiles as well as for scientists and research scholars working on microbiology and products derived from microorganisms.

Contents:
Introduction
Heat stable enzymes from thermophilic microorganisms: biochemical properties and commercial application potential
Proteins and amino acids from thermophilic microorganisms: current research trends and applications
Platform chemicals by thermophiles
Biosurfactants, bioemulsifiers and biopolymers from thermophilic microorganisms
Applications of thermophiles.

Contents:
v. 1. Biology, physiology, physics
v. 2 Clinical applications.

Summary: This book on Thesis Writing for Master's and Ph.D. program focuses on the difficulties students encounter with regard to choosing a guide; selecting an appropriate research title considering the available resources; conducting research; and ways to overcome the hardships they face while researching, writing and preparing their dissertation for submission. Thesis writing is an essential skill that medical and other postgraduates are expected to learn during their academic career as a mandatory partial requirement in order to receive the Master's degree. However, at the majority of medical schools, writing a thesis is largely based on self-learning, which adds to the burden on students due to the tremendous amount of time spent learning the writing skills in addition to their exhausting clinical and academic work. Due to the difficulties faced during the early grooming years and lack of adequate guidance, acquiring writing skills continues to be a daunting task for most students. This book addresses these difficulties and deficiencies and provides comprehensive guidance, from selecting the research title to publishing in a scientific journal.

Contents:
Deciding on the topic/area of research/approval
Conduct of research and analysis
Structuring the material and writing the thesis
Editing the thesis
Publishing and presenting the research work
Thesis for master's degree / specialty and sub-specialty courses in medicine / doctor of philosophy course
Statistical/English language/plagiarism software.

Summary: Plant biotechnology is a most interesting branch for academicians and researchers in recent past. Now days, it becomes a very useful tool in agriculture and medicine and is regarded as a popular area of research especially in biological sciences because it makes an integral use of biochemistry, molecular biology and engineering sciences in order to achieve technological application of cultured tissues, cell and microbes. Plant tissue culture (PTC) refers to a technique of cultivation of plant cells and other parts on artificial nutrient medium in controlled environment under aseptic conditions. PTC requires various nutrients, pH, carbon source, gelling agent, temperature, photoperiod, humidity etc. and most importantly the judicious use of plant growth regulators. Various natural, adenine and phenyl urea derivatives are employed for the induction and proliferation of different types of explants. Several phenyl urea derivatives were evaluated and it was observed that thidiazuron (n-phenyl-N"-1,2,3- thidiazol-5-ulurea) was found to be the most active among the plant growth regulators. Thidiazuron (TDZ) was initially developed as a cotton defoliant and showed high cytokinin like activity. In some examples, its activity was 100 times more than BA in tobacco callus assay and produces more number of shoots in cultures than Zeatin and 2iP. TDZ also showed major breakthrough in tissue culture of various recalcitrant legumes and woody species. For the last two decades, number of laboratories has been working on TDZ with different aspect and number of publications has come out. To the best of our knowledge, there is no comprehensive edited volume on this particular topic. Hence th, e edited volume is a deed to consolidate the scattered information on role of TDZ in plant tissue culture and genetic manipulations that would hopefully prove informative to various researches. Thidiazuron: From Urea Derivative to Plant Growth Regulator compiles various aspects of TDZ in Plant Tissue Culture with profitable implications. The book will provides basic material for academicians and researchers who want to initiate work in this fascinating area of research. The book will contain 26 chapters compiled by International dignitaries and thus giving a holistic view to the edited volume.

Contents:
1. Thidiazuron: Modulator of Morphogenesis in Vitro
2. TDZ
Mode of Action, Use and Potential in Agriculture
3. TDZ-Induced Morphogenesis Pathways in Woody Plant Culture
4. Thidiazuron in Micropropagation of Aroid Plants
5. Use of TDZ for Micropropagation of Some Mediterranean Crop Species
6. Thidiazuron in Micropropagation of Small Fruits
7. TDZ in Cereal Gametic Embryogenesis
8. Preconditioning of Nodal Explants in Thidiazuron Supplemented Liquid Media Improves Shoot Multiplication in Pterocarpus Marsupium (Roxb)
9. Application of Thidiazuron in the Micropropagation of Fagaceae
10. In Vitro Morphogenesis of Woody Plants Using Thidiazuron
11. Thidiazuron Influenced Morphogenesis in Some Medicinal Plants
12. In vitro Morphogenesis of Some Himalayan Flora using TDZ
A Potential Plant Growth Regulator
13. Thidiazuron Induced Protocorm-Like Bodies in Orchid: Progress and Prospects
14. Thidiazuron (TDZ): A Callus Minimizer for In Vitro Plant Production
15. The Applications of TDZ in Medicinal Plant Tissue Culture
16. Factors Affecting Thidiazuron-Induced Direct Somatic Embryogenesis of PHALAENOPSIS Aphrodite
17. TDZ Induced Diverse In vitro Responses in Some Economically Important Plants
18. Regulation of Morphogenesis and Improvement in shoot Multiplication in Vitex Species Using Thidiazuron
19. TDZ-Induced Regeneration in Stevia rebaudiana Bertoni: An Important Natural Sweetener
20. Shoot Organogenesis of Aloe Plants with Emphasis on TDZ
21. Morphogenic Potential of Different Explants of Broccoli (Brassica oleracea L. var. italica): important "nutrient rich" Vegetable, using Thidiazuron.
22. Thidiazuron: A Potent Phytohormone for in Vitro Regeneration
23. TDZ-Induced Plant Regeneration in Jatropha curcas: a promisingBiofuel Plant
24. Role of Thidiazuron in Modulation of Shoot Multiplication Rate in Micropropagation of Rauvolfia Species
25. Effect of TDZ on Various Plant Cultures
26. Role of Thidiazuron in Tissue Culture of Orchids
27. Thidiazuron as an Elicitorin The Production of Secondary Metabolite
28. Thidiazuron: An Effective Plant Growth Regulator on In Vitro Cloning of Slow Growing Economic Rattan Palms in Southern Western Ghats for Eco-Restoration and Consistent Utilisation.

Summary: An online journal and ebook service of the Thieme Publishing Group. The ebook package is also called Thieme Clinical Collections.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: An online journal and ebook service of the Thieme Publishing Group.

Summary: "Thieme Review for the USMLE: A WIN for Step 2 and 3 CK by Manoj Gurung and Yayra Musabek fills a void in the available board prep materials, offering the perfect one-stop reader-friendly resource for acing these exams-truly All What Is Needed (A WIN). Allopathic and osteopathic medical students preparing for the USMLE® Step 2 and Step 3 CK or COMLEX-USA Level 2-CE and Level 3 will benefit from this must have study guide"-- Provided by publisher.

Summary: "The first all-in-one CS review book: Addresses all three exam components: ICE, CIS, and SEP. ICE section provides systematic organization and consistency in its coverage of Medical History Taking, Physical Examination, and Patient Note. SEP section includes word-level concepts (syllables and stress), sound-level concepts (consonants and vowels), and grammar concepts CS for IMGs is a comprehensive resource designed to help IMGs pass the Step 2 CS exam on the first attempt. Practice intensive tools: Role-plays and model videos with standardized patients (SPs). SEP pronunciation and grammar explanations, exercises, and videos. Flowcharts, checklists and self-assessments Easy to replicate approach to target differential diagnosis The text and accompanying audio and videos provide an unparalleled study prep tailored to the CS that will lead to a higher score on this vital exam. Mohamed M. Elawdy, MD, MSc (Urology), is Specialist (A) in Urology, Sohar Hospital, Ministry of Health, Oman and Urology and Nephrology Center, Mansoura, Egypt; International Fellow, Thomas Jefferson University Hospital, Philadelphia, Pennsylvania, USA. Dara B. Oken, MEd, is a Pronunciation Modification Trainer, Articulation LLC and an Adult ELL Teacher , at Minneapolis Adult Education, Minneapolis Center for Adult Learning, Minneapolis, Minnesota, USA. This ground-breaking resource reflects their combined expertise preparing IMGs for the CS exam. As such, it's the only resource needed for USMLE CS prep!"-- Provided by publisher.

Contents:
The Basics, Component 1, Integrated Clinical Encounter
The Basics, Component 2, Communication and Interpersonal Skills
English Proficiency
Chest (Cardiology and Respiratory)
Abdomen (Gastroenterology and Urology)
Obstetrics and Gynecology
Pediatrics
Musculoskeletal System
Psychiatry
Neurology
Miscellaneous
Mini-Cases.

Contents:
Machine generated contents note: pt. 1 Advances in Developmental Science
ch. 1 Life Course Science and the Proverbial Black Box
ch. 2 Defining Adversity and Toxic Stress
ch. 3 Epigenetics
ch. 4 Developmental Neuroscience
ch. 5 Thinking Developmentally
pt. 2 Translating Developmental Science Into Practice and Policy
ch. 6 The Biological Needs of Young Children
ch. 7 Supporting Parents and Caregivers
ch. 8 The Role of Communities
ch. 9 The Role of Pediatric Care
ch. 10 Implications for Pediatric Advocacy and Public Policy.

Summary: "Thinking Race argues that racism results from a misguided blending of biological facts with pernicious socially constructed ideas. This book aims to help readers accept the reality of human difference while understanding human unity"-- Provided by publisher.

Contents:
1. Generations of migration
2. The notion and nature of race
3. Human diversity
4. Race and medicine
5. Race and ability
6. Seeking solutions.

Summary: This book aims to provide a deeper understanding of Third Mobile Window Syndrome and its various forms beyond just Superior Canal Dehiscence. It will illuminate the various presentations of Third Mobile Window Syndrome, provide the means for diagnosis, and elucidate treatments. The disorder Superior Semicircular Canal Dehiscence Syndrome was discovered in 1995 by Dr Lloyd Minor at The John Hopkins University School of Medicine in Baltimore. Though he published his findings in 1998, there remains no book wholly devoted to the topic. For this reason, many neurotologists and otorhinolaryngologists still misunderstand this condition and its presentation. Structured in six parts, the first part will be important in providing a context, and drawing together all of the learning that has been acquired since 1998, as well as explaining the complexities of the condition. The second and third parts will set out to detail all the aspects that are necessary for diagnosing a patient and then deciding on the best form of treatment, surgical or otherwise. Part four covers special situations, including bilateral SCDS and the pediatric patient. In part five, Philippa Thomson, a patient herself, will describe the patient perspective of symptoms and the complicated journey of identifying a diagnosis and securing expert care. Finally, part six covers future research. Third Mobile Window Syndrome of the Inner Ear: Superior Semicircular Canal Dehiscence and Associated Disorders will provide clinicians involved in the treatment of inner ear disorders, balance dysfunction, and dizziness with the expertise they need to assist patients with Third Mobile Window Syndrome. It will also supply useful information to neurotologists/otologists, otolaryngologists, and neurologists. Researchers in the field of inner ear disorders will also find this to be a valuable text. .

Contents:
History of third mobile window syndrome
Etiology
Pathophysiology
The Otologic Mimicker: Vestibular and Auditory Symptoms
The cognitive/psychological effects
Other kinds of dehiscences
Perilymphatic Fistula
Diagnosis
Vestibular Symptoms & Magnitude of Disease
Taking the patient history (interview questions)
Diagnostics
Imaging
Treatment
Medical therapy
Visual manifestations & treatment
Surgical Intervention, Revision Surgery and Surgical Complications
Special situations
Bilateral SCDS
Future Research
From The Patient Perspective
Patients experiences
Patient Stories
Mismanagement of patients.

Summary: The first IVF conceived birth in 1978 resulted in a significant growth of third party reproductive options which continue to raise ethical, legal, and psychological questions. Third party reproduction procedures can involve as many as five people: sperm donor, egg donor, gestational carrier, and intended parents. Third-Party Reproduction: A Comprehensive Guide utilizes experts in the field to address the medical, psychological, ethical and legal aspects of sperm donation, egg donation, embryo donation, and the use of gestational carriers. In addition, there are chapters on the medical and ethical aspects of posthumous reproduction, religious aspects of third party reproduction, and how to avoid pitfalls of third party reproduction. Aimed at physicians, trainees, psychologists, nurses, and social workers whose practices may include patients considering third party reproduction, the intent of this book is to provide a comprehensive and practical overview of the many aspects of third party reproduction to help all those involved to better understand them. Patients considering third party reproduction may also find value in this book.

Contents:
Medical Implications of Oocyte Donation
Oocyte Donation: Legal Aspects
Oocyte Donation: Psychological Aspects
Oocyte Donation: Ethical Aspects
Gestational Carrier: Medical Aspects
Surrogacy and Gestational Carrier Arrangements: Legal Aspects
Use of Gestational Carriers: Psychological Aspects
The Ethics of Hiring a Gestational Carrier
Embryo Donation: Medical Aspects
Embryo Donation: Legal Aspects
Embryo Donation: Psychological Aspects
Embryo Donation: Ethical Issues
Donor Insemination
Sperm Donation: Legal Aspects
Sperm Donation: Psychological Aspects
Sperm Donation: Ethical Aspects
Medical Aspects of Posthumous Reproduction
Ethical Implications of Posthumous Reproduction
Hagar's Child:? Theology, Ethics, and the Third Party in Emerging Reproductive Technology
Choosing Egg Donors and Gestational Carriers: Avoiding the Pitfalls.

Summary: "The past twenty-five years have witnessed a revolution in the science of addiction, yet we still rely upon sorely outdated methods of treatment. Expensive new programs for managing addiction are also flourishing, but since they are not based in science, they offer little benefit to people who cannot afford to lose money or faith in their recovery. Clarifying the cutting-edge science of addiction for practitioners and general readers, The Thirteenth Step pairs stories of real patients with explanations of key concepts relating to their illness. A police chief who disappears on the job illustrates the process through which a drug can trigger the brain circuits mediating relapse. One person's effort to find a burrito shack in a foreign city illuminates the reward prediction error signaled by the brain chemical dopamine. With these examples and more, this volume paints a vivid, relatable portrait of drug seeking, escalation, and other aspects of addiction and suggests science-based treatments that promise to improve troubling relapse rates. Merging science and human experience, The Thirteenth Step offers compassionate, valuable answers to anyone who hopes for a better handle on a pernicious and confounding disease."--Publisher description.

Contents:
Us and them
A grocery store that closed
An entity in its own right
A chronic, relapsing disorder
Man or machine?
Histories, brains, and behaviors
The pursuit of happiness
The dark side of addiction
Rash actions
Turning on a red light
Getting the cue
A strained mind
Fathers and sons
Molecular culprits
Trick or treatment
Please behave
Pills for addiction ills
Pray if you wish, but please take your meds first
The journey ahead.

Summary: "There's a long-running joke that, after coming out as a lesbian, gay, bisexual, transgender, or intersex person, you should receive a membership card and instruction manual. This is that instruction manual. You're welcome. Inside this revised and updated edition, you'll find the answers to all the questions you ever wanted to ask: from sex to politics, hooking up to stereotypes, coming out and more. This candid, funny, and uncensored exploration of sexuality and what it's like to grow up LGBTQIA+ also includes real stories from people across the gender and sexual spectrums, not to mention hilarious illustrations"--Back cover.

Contents:
Welcome to the members' club
The name game
You can't mistake our biology
Stereotypes are poo
The fear
Haterz gon' hate
Coming out
Where to meet people like you
The ins and outs of gay sex
Nesting
Hats
A guide to recognizing your gay saints
Build a bridge : guidance for parents and carers of LGBTQ+ youth
The cheat sheet
Helpful numbers and websites and stuff.

Summary: Although many things can go wrong in the brain, this book also shows that our brain is strong. It highlights the key findings that can be seen on magnetic resonance imaging (MRI) and computed tomography (CT) scans, including those related to normal brain aging and common diseases such as brain infarcts, fractures of the skull as well as fractures and tumors of the vertebral column. It offers insights into brain MRI and CT scans, enabling readers to interpret the key findings.

Contents:
CT and MRI scans : the basic principles
CT and MRI scans : different types of images
The anatomy of the human brain
White spots
Shrinking brain
Silent infarcts
Previous microbleeds
More room around the blood vessels
Cerebral infarction
Intracranial haemorrhages
Blockage of a blood vessel carrying blood from the brain
Blocked paranasal sinuses
Multiple Sclerosis
Bulging intervertebral discs
Spinal stenosis
Blood vessels of the neck
The intracranial blood vessels
Ruptured aneurysm
Skull fractures
Post-accident haematoma
Vertebral fracture
Encephalitis
The causes of epilepsy
Non-aggressive brain tumours
Aggressive brain tumours
Metastatic brain tumours
Metastatic spinal tumours
Too much cerebrospinal fluid
Dementia and Alzheimer's disease
Arteriovenous malformation
Tumours arising from the Meninges
Co-occurring multiple cerebral infarcts
Vestibular schwannoma
Pituitary adenomas
Otitis : inflammation of the ear
The eyes and the optic nerve
The cerebellum
The brain, age 0 to age 100
The post-operative brain
Many things remain unknown
Erratum to : This is our brain
Afterword : My own brain.

Summary: First published in 1966, Thompson and Thompson Genetics and Genomics in Medicine has become an essential textbook for medical students, genetic counseling students, students in laboratory medicine, and more advanced trainees. With its focus on fundamental principles in human genetics and genomics and their application to medicine, the book has served many as a well-thumbed resource they return to over and over. Such students can continue to depend on this valuable text, joining those in newer fields of genome data analysis for all they need to know about genetics and genomics throughout their basic science training, clinical placements and beyond. Coverage includes new discoveries--such as the functional roles of non-coding RNAs, chromatin regulation and epigenetics--latest technologies, and new diagnoses they are enabling.

Contents:
Introduction
Introduction to the Human Genome
The Human Genome : Gene Structure and Function
Human Genetic Diversity : Human Genetic Diversity: Genomic Variation
Principles of Clinical Cytogenetics and Genome Analysis
The Chromosomal and Genomic Basis of Disease : Disorders of the Autosomes and Sex Chromosomes
Patterns of Single-Gene Inheritance
Principles of Clinical Epigenetics
Complex Inheritance of Common Multifactorial Disorders
Population Genetics for Genomic Medicine
Identifying the Genetic Basis for Human Disease
The Molecular Basis of Genetic Disease
The Molecular, Biochemical, and Cellular Basis of Genetic Disease
The Treatment of Genetic Disease
Developmental Genetics and Birth Defects
Cancer Genetics and Genomics
Genetic Counseling and Risk Assessment
Preconception and Prenatal Screening and Diagnosis
Application of Genomics to Medicine and Individualized Health Care
Ethical and Social Issues in Genetics and Genomics.

Contents:
Introduction to the human genome
The human genome: gene structure and function
Human genetic diversity: mutation and polymorphism
Principles of clinical cytogenetics and genome analysis
The chromosomal and genomic basis of disease: disorders of the autosomes and sex chromosomes
Patterns of single-gene inheritance
Complex inheritance of common multifactorial disorders
Genetic variation in populations
Identifying the genetic basis for human disease
The molecular basis of genetic disease : general principles and lessons from the hemoglobinopathies
The molecular, biochemical, and cellular basis of genetic disease
The treatment of genetic disease
Developmental genetics and birth defects
Cancer genetics and genomics
Risk assessment and genetic counseling
Prenatal diagnosis and screening
Application of genomics to medicine and personalized health care
Ethical and social issues in genetics and genomics.

Contents: <br/
>1. Surgical technique and a clinical study on 79 patients.

Contents:
Radiographic technique (fluoroscopy, digital radiography, CT, dual energy CT, dose reduction strategies) / Mannudeep K. Kalra and Alexi Otrakji
Normal anatomy and radiographic signs / Melissa Price
Thoracic MRI : technique and approach to diagnosis (anatomic definition, diffuse disease, masses benign and malignant, except congenital) / Jeanne B. Ackman
Pet/ct/, pet/mri : technique, pitfalls and findings / Bojan Kovacina
The mediastinum (anatomic definition, diffuse disease, masses benign and malignant, except congenital) / Lan Qian (Lancia) Guo and Jeanne B. Ackman
The airways (small and large airways) / Brett Carter
The pleura, diaphragm, and chest wall / Lan Qian (Lancia) Guo and Jeanne B. Ackman
Congenital thoracic malformations / Justin Stowell and Christopher M. Walker
Thoracic lines and tubes / Matthew Gilman
Acute thoracic conditions in the intensive care unit / Susan E. Gutschow and Christopher M. Walker
Pulmonary embolism & pulmonary vascular diseases / Shaunagh McDermott
The post-operative chest (expected and unexpected findings) / Bojan Kovacina
Thoracic trauma / Efren Flores and Jeanne B. Ackman
Community acquired infections (findings and complications, including endemic fungal, viral and bacterial infections) / John Nance
Pulmonary disease in the immunocompromised patient / Hristina Natcheva
Mycobacterial infections (TBC and atypical infections) / Thomas Keimig, Jo Anne Shepard and Gerald Abbott
Approach to diffuse lung disease : anatomic basis and HRCT / Amita Sharma
Diffuse lung diseases (interstitial pneumonias, smoking related/ inhalational/occupational) / Jonathan H. Chung
Pneumoconioses / Victorine Muse
Obstructive lung diseases / Carol C. Wu, Brett Carter and Jo Anne Shepard
Pulmonary tumors and lymphoproliferative disorders / Mylene Truong, Carol C. Wu, Brett Carter and Bradley S. Sabloff
Solitary pulmonary nodule & pulmonary nodule management / Milena Petranovic
Lung cancer screening / Shaunagh McDermott
Staging of lung cancer (imaging and surgical evaluation) / Bojan Kovacina
Interventional techniques / Florian J. Fintelmann, Jo Anne Shepard and Amita Sharma.

Summary: Prepare for the thoracic imaging component of the new radiology Core Exam with Thoracic Imaging: A Core Review! Excel on your boards with this review book, written specifically for the new exam format. Study with all the books in the Core Review Series to ace every area of the Core Exam!

Contents:
Basics of imaging
Normal anatomy
Terms and signs
Intensive care unit radiographs
Pulmonary pathology
Diseases of the pleura, chest wall, and diaphragm
Mediastinal disease
Vascular disease
Lung cancer
Trauma
Congenital disease
Postoperative thorax.

Summary: This book covers the imaging of thoracic structures with a focus on evaluation of the lungs. Pulmonary conditions are the most common global cause of mortality and morbidity, with lung cancer and tuberculosis being prevalent diseases in the developed and developing world, respectively. In the last few years there have been rapid changes in the imaging interpretation of lung diseases, particularly imaging of idiopathic pulmonary fibrosis. However, updated literature is not available yet. Filling this gap, the book provides radiologists with up-to-date, handy information on reading chest scans. This book uses standard terms and lexicons to describe the imaging findings. It consists of 14 chapters, and includes more than 1200 illustrations covering both commonly and rarely encountered conditions. The first chapter discusses imaging patterns and signs in thoracic imaging, while the chapter on interstitial lung diseases describes the hallmarks that are useful in the diagnostic pathway of these diseases. This chapter also incorporates the latest diagnostic categories of UIP based on CT patterns, and provides pictorial examples. Written by experts in the field, the book highlights imaging features and relevant clinical findings that may help in reaching diagnosis, and wherever possible, it presents the imaging features in tables for ease of memorizing.

Contents:
Patterns and signs in thoracic imaging
Imaging of large and small airways
Imaging of cystic lung diseases
Imaging of pulmonary nodules
Imaging of thoracic malignancies
Imaging of thoracic infections
Imaging of pulmonary infections
Imaging of ICU patients
Imaging of the mediastinum
Imaging of pulmonary artery
Imaging of the aorta
Imaging of the esophagus
Imaging of chest wall and pleura
Imaging of interstitial lung diseases
Imaging of miscellaneous diseases.

Summary: "Written by two of the world's most respected specialists in the field, Thoracic Imaging: Pulmonary and Cardiovascular Radiology, Third Edition brings you completely up to date with all you need to know for optimal imaging of the heart and lungs. This comprehensive title provides practical, authoritative guidance for the radiologic assessment and diagnosis of both congenital and acquired cardiovascular and pulmonary diseases. A must-have reference for more than ten years, Thoracic Imaging is your one-stop source for current, accurate coverage of pulmonary infections, diffuse lung diseases, mediastinal masses, coronary artery CT, myocardial disease, pericardial disease, CT of ischemic heart disease, and much more. Key Features: Today's most comprehensive text-reference in the field, written by pulmonary imaging expert W. Richard Webb, MD and cardiac imaging expert Charles B. Higgins, MD. More than 2700 high-quality images, many in full color, help you visualize key aspects of chest imaging. A new chapter on MR and CT in in Atrial and Ventricular Arrhythmias brings you up to date on the latest imaging techniques. Updated images and content throughout, including expanded coverage of PET/CT. Now with the print edition, enjoy the bundled interactive eBook edition, which can be downloaded to your tablet and smartphone or accessed online and includes features like: Complete content with enhanced navigation, Powerful search tools and smart navigation cross-links that pull results from content in the book, your notes, and even the web. Cross-linked pages, references, and more for easy navigation. Highlighting tool for easier reference of key content throughout the text. Ability to take and share notes with friends and colleagues. Quick reference tabbing to save your favorite content for future use --Provided by publisher. "... Your one-stop source for current, accurate coverage of pulmonary infections, diffuse lung diseases, mediastinal masses, coronary artery CT, myocardial disease, pericardial disease, CT of ischemic heart disease, and much more."--Provided by publisher.

Contents:
Section one: the basics. Lobar anatomy airspace consolidation, the silhouette sign, and atelectasis
The normal mediastinum
The pulmonary hila
Section two: neoplasms masses and focal lung abnormalities. Lung cancer and bronchopulmonary neoplasms
Metastatic tumor
Lymphoma and lymphoproliferative disease
The mediastinum: mediastinal masses
Congenital lung abnormalities and pulmonary vascular malformations
Solitary and multiple nodules masses, cavities, and cysts
Section three: diffuse and multifocal lung diseases. Plain film and computed tomographic assessment of diffuse lung disease
Pulmonary edema, the acute respiratory distress syndrome, and radiology in the intensive care unit
Pulmonary infections
The idiopathic interstitial pneumonias
Collagen vascular diseases
Sarcoidosis
Allergic lung diseases: hypersensitivity pneumonitis and eosinophilic lung disease
Iatrogneic lung diseases: drug-induced lung disease and radiation pneumonitis
Pneumoconioses
Pulmonary vasculitis and diffuse alveolar hemorrhage
L diffuse lung disease associated with lipid: exogenous pneumonia and alveolar proteinosis
Diffuse lung diseases associated with calcification
Section four: airway abnormalities. The trachea
Airway disease: bronchiectasis, chronic bronchitis, and bronchiolitis
Section five: COPD, emphysema, and cystic lung diseases. Chronic obstructive pulmonary disease and emphysema
Diffuse cystic lung diseases
Section six: Pleural abnormalities. The pleura and pleural disease
Section seven: great arteries. Pulmonary thromboembolic disease
Pulmonary hypertension
CT and MRI of the thoracic aorta
Section eight: radiography of heart disease. Radiography of acquired heart disease. Radiography of congenital heart disease
Section nine: acquired non-ischemic heart disease. Valvular heart disease
Myocardial diseases
Pericardial diseases
Cardiac and paracardiac masses
Section ten: congenital heart disease. Magnetic resonance imaging of congenital heart disease
Section eleven: ischemic heart disease. Magnetic resonance imaging of ischemic heart disease computed tomography of coronary arteries and ischemic heart disease
Section twelve: cardiac arrhythmias. Atrial and ventricular arrhythmias

Summary: This extensively revised edition is an essential reference for physicians involved in the diagnosis, referral and treatment of the thoracic outlet syndrome (TOS). TOS is made up of a constellation of problems resulting from pathology at the thoracic outlet in the neck. Busy specialty practice sees multiple affected patients in every clinic, but TOS can often be difficult to diagnosis. Thoracic Outlet Syndrome explores all possible ancillary care issues surrounding this complex condition, including rehabilitation, disability, natural history and medicolegal issues, and aims to stimulate research, discussion and a sense of community between professionals involved in this area. Vascular and thoracic surgeons, neurosurgeons, neurologists, psychiatrists and psychologists, physical therapists, occupational medicine specialists and pain specialists will find this book a must read for successful treatment, referral and diagnosis of TOS in clinical practice.

Summary: This book offers a comprehensive overview of all major pathologic conditions involving the lung and mediastinum and the related diagnostic procedures. Oncologic and non-oncologic conditions are reviewed and described in detail, featuring, besides normal anatomy, also high quality images from several modalities (including X-ray, CT, MR and PET), as well as b/w and color illustrations and line drawings. Complications associated with surgical and oncological treatments are also presented in detail with extensive imaging examples. The book provides a thorough coverage of the topic of thoracic imaging, yet considering a concise and synthetic approach essential to optimal learning. The book will be a useful reference guide for the everyday clinical practice of young radiologists, residents and medical students.

Contents:
Thoracic anatomy
Glossary
Lung nodules
Lung cancer staging
Mediastinal masses
Imaging of the lung after surgercy, radiation therapy and chemotherapy
Pneumonia and bronchiolitis
Interstitial lung disease
Pleural pathology
Chest x-ray interpretation.

Summary: This book provides a guide to the anatomy and the surgical techniques required in thoracic and cardiothoracic surgery. It discusses the advantages and disadvantages of certain surgical procedures in relation to the lymphatic system, thyroid gland, chest wall and parathyroid glands, as well as pulmonary endarterectomy. Further, it addresses intraoperative and postoperative complications, and explores newer fields like microthymectomy, microlobectomy, and pain management for thoracic surgery patients. Providing an update on the latest advances in thoracic surgery, it appeals to general, thoracic, cardiothoracic, and cardiovascular surgeons. It also offers trainees insights into the foundation of the techniques and the relevant anatomy. .

Contents:
General Aspects of Thoracic Surgery
Surgical approaches and investigation techniques to the mediastinal lymph nodes
Surgical Techniques for Chest Wall Diseases
Minimally invasive left pulmonary resections techniques
Chest Tube
Approaches and surgical techniques for mediastinal infectious diseases
General Aspects in the Pathology of the Diaphragm
Approaches and surgical techniques for retrocostoxiphoid hernias
Anesthesia in lung transplantation
Thoracic traumas - general aspects
Approaches and surgical techniques for chest wall trauma.

Summary: Take your surgical skills to the next level with Thoracic Surgery: Transplantation, Tracheal Resections, Mediastinal Tumors, Extended Thoracic Resections, a volume in the Master Techniques in Surgery Series! This thoracic surgery reference provides the richly illustrated, step-by-step guidance you need to perfect a full range of thoracic surgery techniques, avoid and manage complications, and achieve optimal outcomes. Key features: see exactly how to perform the full range of procedures, both open and minimally invasive, for lung transplantation, thoracic outlet syndrome, pectus repair, diaphr.

Contents:
Part I: Endoscopy
Rigid/flexible bronchoscopy / Douglas J. Mathiesen
Airway stenting / Aaron M. Cheng, Douglas E. Wood
Part II: Lung resection: General principles
Endobronchial and endoscopic ultrasound staging in lung cancer / Jordan Krazakov, Moishe Liberman
Mediastinoscopy: Current role in thoracic surgery and management of complications / Tibor Krajc, Michael Rolf Mueller
Transcervical extended mediastinal lymphadenectomy (TEMLA) for staging of nonsmall cell lung cancer / (NSCLC) / Martin Zieliński [and others]
Mediastinal node dissection right/left (VATS/Open) / Hiroshi Date
Robotic lymph node dissection / Franca M.A. Melfi, Olivia Fanucchi, Alfredo Mussi
Techniques/complications of thoracotomy / Dan J. Raz
Part III: Lung resection: Lobectomy
Right upper lobe: Open / Walter Weder, Ilhan Inci
Right upper lobe: VATS / Michael J. Weyant
Open middle lobectomy / Gunda Leschber
Right middle lobe: VATS / Michael J. Weyant
Right lower lobe: Open / Ralph A. Schmid, Gregor J. Kocher
Right lower lobe: VATS / Michael J. Weyant
Open left upper lobectomy / N. Golan, Thomas K. Waddell
Left upper lobe: VATS / Michael Lanuti
Left lower lobectomy: Open / David Tom Cooke
VATS lower left lobectomy / Daniel G. Nicastri, Oskar Kizhner, Todd S. Weiser
Precision cautery laser excision / Tae H. Song, Christopher R. Morse
Robotic approach to lobectomy / Benjamin Wei, Robert James Cerfolio
Part IV: Lung resection: Segmentectomy
Right upper lobe (Anterior, posterior, apical) / Laureano Molins [and others]
VATS right upper lobe (RUL) segmentectomy / Andrew J. Kaufman, Raja M. Flores
Superior and basilar right lower lobe segmentectomies / Gaetano Rocco
Video-assisted thoracoscopic right superior and basilar segmentectomy / M. Blair Marshall, Dominic Emerson
Left upper lobe segmental resection: Lingula and superior division--Open approach / N. Golan, Thomas K. Waddell
Left upper lobectomy: VATS / Robert E. Merritt
Left lower lobe segmentectomy (superior and basilar): Open techniques / Sean C. Grondin, Colin Schieman
Left lower lobe segments--VATS / Hugh G. Auchincloss, Christopher R. Morse
Part V: Lung resection: Superior sulcus resection
Anterior approach to lung cancers invading the thoracic inlet / Olaf Mercier, Elie Fadel, Philippe Dartevelle
Superior sulcus resection-posterior approach / Cameron D. Wright
Thoracic en bloc spondylectomy / Claudio E. Tatsui, Laurence D. Rhines, Garrett L. Walsh
Part VI: Lung resection: EPP
Extrapleural pneumonectomy / Valerie W. Rusch
Pleurectomy and pneumonectomy / Andrew J. Kaufman, Raja M. Flores
Part VII: Lung resection: Broncoplastic procedures/vascular reconstructions
Upper right sleeve lobectomy / John D. Mitchell
Right middle lobe sleeve resection / Mara B. Antonoff, Bryan F. Meyers
Right lower and middle lobe sleeve lobectomy / Douglas J. Mathieson
Left upper sleeve lobectomy / Federico Venuta [and others]
Left lower lobe sleeve resection / Paula A. Ugalde [and others]
Right and left mainstem bronchial sleeve resections / Smita Sihag, Douglas J. Mathieson
Pulmonary artery sleeve resection and lobectomy / Antonio D'Andrilli, Federico Venuta, Erino A. Rendina
VATS sleeve lobectomy / Robert J. McKenna Jr
Part VIII: Lung resection: Carinal resection
Neocarina / John C. Wain
Right carinal sleeve pneumonectomy: Transsternal approach / John C. Wain
Right carinal sleeve pneumonectomy: Transthoracic / Michael Lanuti
Carinal right upper lobectomy / Harald C. Ott, Douglas J. Mathieson
Left carinal resection / Cameron D. Wright
Carinal resection: Pneumonectomy stump recurrence / Eric H. Twerdahl, Douglas J. Mathieson
Part IX: Management complications
Transsternal repair of postpneumonectomy bronchopleural fistual / Olaf Mercier, Marc de Perrot, Shaf Keshavjee
Transthoracic repair bronchopleural fistula / Francis C. Nichols
Muscle flaps for general thoracic surgeons / Mark S. Allen
Omental flap / Bryan M. Burt, Joseph B. Shrager
Persistent air leaks/pleural spaces / Douglas J. Mathieson, Christopher R. Morse.

Summary: Take your surgical skills to the next level with Thoracic surgery: transplantation, tracheal resections, mediastinal tumors, extended thoracic resections, a volume in the Master techniques in surgery series! This thoracic surgery reference provides the richly illustrated, step-by-step guidance you need to perfect a full range of thoracic surgery techniques, avoid and manage complications, and achieve optimal outcomes.

Contents:
Lung transplantation/chronic lung disease
Chest wall/pleural space/diaphragm: TOS
Chest wall/pleural apace/diaphragm: pectus repair
Chest wall/pleural space/diaphragm: chest wall
Chest wall/pleural space/diaphragm: diaphragm
Chest wall/pleural space/diaphragm: pleural space
Mediastinal tumors: thymus
Mediastinal tumors: neurogenic
Trachea
Vascular procedures.

Summary: This volume is a "how-to guide" to treating thoracic trauma and emergencies for acute care surgeons. It highlights the diagnosis and management of thoracic disease and injuries, and each chapter includes algorithms that lead readers through the process of identifying and treating many common and some uncommon thoracic pathologies. The international team of authors provides readers with a unique and diverse approach to the operative and non-operative challenges encountered by ACS surgeons. The large number of figures offers readers insights into what they can expect to see when caring for these patients. The editors understand that the management of adults and children differ and have included a specific chapter on pediatrics. Given the broad audience and diverse settings in which the text can be used, the authors also provide details of care in limited-resource environments. The volume is a valuable tool for professionals interested in thoracic surgery and acute care surgery

Summary: This heavily revised second edition of this book provides a comprehensive overview of both common and rarely performed thoracic surgical techniques. Techniques covered include thymectomy, left and right lower lobectomy, rib resection for empyema, median sternotomy and lung biopsies. Emphasis is focused on the practical steps necessary to successfully and reliably perform the techniques covered, while acknowledgement is also given to individual variations in how these techniques are performed. Thoracic Surgical Techniques provides a detailed clinical illustrative guide for successfully performing a range of procedures reliably. Its large number of detailed illustrations and concise technical descriptions provides an invaluable resource for all practising and trainee thoracic surgeons.

Summary: The incidence of pleural disease is increasing, and it is now accepted that best practice requires the incorporation of thoracoscopy into the work-up. However, surgeons cannot meet the rising demand for thoracoscopy by means of video-assisted thoracoscopic surgery (VATS), and waiting lists for endoscopic pleural procedures are consequently lengthening. Against this background, there is an increasing need for medical thoracoscopy performed by pulmonologists, which may be video assisted and has the advantage of being very cost-effective. This book is a comprehensive and up-to-date guide to thoracoscopy for pulmonologists that documents the considerable progress in endoscopic telescopes and instrumentation. Clear practical guidance is provided on technique, and diagnostic, therapeutic, and interventional applications of thoracoscopy are all carefully examined with the aid of high-quality illustrations. Although medical thoracoscopy is much less invasive than VATS and thoracotomy, complications can occur in a small number of cases; these are discussed and advice on prevention is provided. The concluding section examines the future of the field, covering developments such as 'mini' thoracoscopy, autofluorescence thoracoscopy, and flexi-rigid thoracoscopy.

Contents:
Part I. The Pleura and Thoracoscopy Technique
Part II. Thoracoscopy for the Beginners
Part III. Interventional Thoracoscopy
Part IV. Advanced Thoracoscopy
Part V. Complications of Thoracoscopy and Management
Part VI. Future in the Field of Thoracoscopy.

Summary: This book highlights the differences, in terms of neoplastic dissemination pathways, between various types of thoracic cancers. It presents and discusses a comprehensive schematic overview of tumors of the lung parenchyma, of the mediastinum, of the pleura, and of the chest wall. For each tumor, it details the local spread and the lymphatic and vascular dissemination, and it describes the challenging staging of lung tumors with mutations. Illustrations and artwork enrich the content and help readers to understand and visualize tumor spread. The book is of great interest to professionals involved in the study, diagnosis and treatment of thoracic pathologies, as well as to residents in radiology, oncology and pulmonology.

Contents:
Chapter 1: Mechanisms of tumour dissemination in thoracic neoplasms
Chapter 2: Radiological Signs of Tumour Dissemination
Chapter 3: NSCLC: common types
Chapter 4: NSCLC: rare types
Chapter 5: Pulmonary neuroendocrine tumours
Chapter 6: Tumours of the thymus
Chapter 7: Other Mediastinal tumours
Chapter 8: Tumours od the Pleura
Chapter 9: Tumours of the chest wall.

Summary: "For all we hear of neuroscience's great advances, the field has generated more questions than answers. We know that the brain combines sensory input from all over your body into a single perception, but not how. We think brains "compute" in some sense, but we can't say what those computations are. We believe that the brain is organized as a hierarchy, with different pieces all working collaboratively to make a single model of the world. But we can explain neither how those pieces are differentiated, nor how they collaborate. Neuroscientist and computer engineer Jeff Hawkins argues that it's so hard to answer questions about the brain because our basic picture of how the brain works is wrong. In A Thousand Brains, Hawkins takes a radically new approach to the brain, with stunning implications. Hawkins' proposal, called the Thousand Brains Theory of Intelligence, is that your brain is organized into thousands upon thousands of individually computing units, called cortical columns. These columns all process information from the outside world in the same way, and each builds a complete model of the world. But because every column has different connections to the rest of the body, each has a unique frame of reference. Your brain sorts out all those models by conducting a vote. The fundamental job of the brain, therefore, is not to build a single thought, but to manage the thousands of individual thoughts it has every moment. With this powerful new framework, Hawkins is able to reassess some of neuroscience's most stubborn problems, like why pain needs to be painful to be useful, how we can understand that our perspective of a thing changes as we move around it, and why we might be conscious but individual pieces of our body aren't. And once you understand how the brain works, it is a lot easier to make one yourself. Hawkins is, above all, an engineer, and A Thousand Brains outlines how a new understanding of intelligence could lead to truly intelligent AI. Hawkins explores how we might create machines that can learn on their own, why we need not fear superintelligent systems, and how human and machine intelligence may someday merge. Combining cutting-edge theoretical neuroscience with an ambitious program for tomorrow's digital minds, A Thousand Brains heralds a revolution in the study of intelligence. It is a big-think book, in every sense of the word"-- Provided by publisher.

Contents:
A new understanding the brain. Older brain, new brain ; Vernon Mountcastle's big idea ; A model of the world in your head ; The brain reveals its secrets ; Maps in the brain ; Concepts, language, and high-level thinking ; The thousand brains theory of intelligence
Machine intelligence. Why there is no "I" in AI ; When machines are conscious ; The future of machine intelligence ; The existential risks of machine intelligence
Human intelligence. False beliefs ; The existential risks of human intelligence ; Merging brains and machines ; Estate planning for humanity ; Genes versus knowledge
Final thoughts.

Contents:
Chapter 1. FIB-SEM of mouse nervous tissue: Fast and slow sample preparation / Anna M. Steyer, Andreas Schertel, Christos Nardis, Wiebke Möbius
Chapter 2. Expedited large-volume 3-D SEM workflows for comparative microanatomical imaging / Gerald John Shami, Delfine Cheng, Filip Braet
Chapter 3. Serial-section electron microscopy using automated tape-collecting ultramicrotome (ATUM) / Valentina Baena, Richard Lee Schalek, Jeff William Lichtman, Mark Terasaki
Chapter 4. Serial block face-scanning electron microscopy for volume electron microscopy / Saskia Lippens, Anna Kremer, Peter Borghgraef, Christopher J. Guérin
Chapter 5. Combining serial block face and focused ion beam scanning electron microscopy for 3D studies of rare events / Christopher J. Guérin, Anna Kremer, Peter Borghgraef, Andy Y. Shih, Saskia Lippens
Chapter 6. Yeast membraneless compartments revealed by correlative light microscopy and electron tomography / Guendalina Marini, Gaia Pigino
Chapter 7. In situ analysis of male meiosis in C. elegans / Gunar Fabig, Anna Schwarz, Cynthia Striese, Michael Laue, Thomas Müller-Reichert
Chapter 8. Software for automated acquisition of electron tomography tilt series / Guenter P. Resch
Chapter 9. In situ cryo-electron tomography and subtomogram averaging of intraflagellar transport trains / Mareike A. Jordan, Gaia Pigino
Chapter 10. CryoSTEM tomography in biology / Sharon G. Wolf, Michael Elbaum - Chapter 11. Subtomogram averaging from cryo-electron tomograms / Kendra E. Leigh, Paula P. Navarro, Stefano Scaramuzza, Wenbo Chen, Yingi Zhang, Daniel Castaño-Díez, Misha Kudryashev
Chapter 12. Computational methods for stitching, alignment, and artifact correction of serial section data / Stephan Saalfeld
Chapter 13. Content-aware image restoration for electron microscopy / Tim-Oliver Buchholz, Alexander Krull, Réza Shahidi, Gaia Pigino, Gáspár Jékely, Florian Jug.

Summary: "This edited volume discusses the application of very diverse human organotypic models in major areas of biomedical research. The authors lay a main focus on infectious diseases, cancer, allergies, as well as drug/vaccine discovery and toxicology studies. Representing a valid alternative to laboratory animals, these models are relevant for most areas of translational research. As the contemporary research shows, many human tissues can today be cultivated in vitro and used for several research objectives. This book provides an unprecedented overview of recent developments in an exciting field of research methodology. It is a reference guide for scientists in both academia and industry. Readers can update their knowledge and get hands-on recommendations on how to set up an organotypic model in their lab."--Back cover.

Contents:
Part I. Three dimensional human organotypic models for studying infectious diseases. Three dimensional human organotypic models for studying skin pathogens / Elena Boero, Malgorzata Ewa Mnich, Andrea Guido Oreste Manetti, Elisabetta Soldaini, Luca Grimaldi and Fabio Bagnoli
Human organotypic respiratory models / Mattias Svensson and Puran Chen
Human gastrointestinal organoid models for studying microbial disease and cancer / Jayati Chakrabarti, Martha B. Dua-Awereh, Loryn Holokai and Yana Zavros
Human organotypic models for anti-infective research / Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti and Fabio Bagnoli
Part II. Three dimensional human organotypic models for studying non-infectious diseases. Progress on reconstructed human skin models for allergy research and identifying contact sensitizers / Charlotte Rodrigues Neves and Susan GIbbs
Cancer explant models / Christian T. Stackhouse, George Yancey Gillespie and Christopher D. Willey
Organotypic models of lung cancer / Anna Pomerenke
Pancreatic cancer organotypic models / Abigail Coetzee, Richard Grose and Hemant Kocher
Breast organotypic cancer models / Pilar Carranza-Rosales, Nancy Elena Guzmán-Delgado, Irma Edith Carranza-Torres, Ezequiel Viveros-Valdez and Javier Morán-Martinez
Preclinical organotypic models for the assessment of novel cancer therapeutics and treatment / Carol Ward, James Meehan, Mark Gray, Ian H. Kunkler, Simon P. Langdon, Alan Murray and David Argyle
Overview and comparison of intestinal organotypic models, intestinal cells, and intestinal explants used for toxicity studies / Marc Maresca, Philippe Pinton, El Hassan Ajandouz, Sandrine Menard, Laurent Ferrier and Isabelle P. Oswald
Correction to: Human organotypic models for anti-infective research / Astrid Hendriks, Ana Rita Cruz, Elisabetta Soldaini, Andrea Guido Oreste Manetti and Fabio Bagnoli.

Contents:
1. Mechanisms of thrombosis
2. Pharmacokinetics and pharmacodynamics of fibrinolytic agents
3. Thrombolytic therapy: evidence-based results from multicenter control trials
4.Patients for thrombolysis
5. Anticoagulation as adjunctive treatment and one-hour alteplase infusion
6. Current guidelines and recommendations for thrombolysis use in pulmonary embolism
7. Thrombolysis in pulmonary embolism
8. Thrombolysis in special situations
Index.

Summary: In this book, leaders in the field explore our current understanding of thrombosis and hemostasis in cancer and address key questions on the subject. Among the topics discussed are the mechanisms that cancers use to activate the coagulation system, and those by means of which an activated coagulation system can lead to more aggressive cancer growth. Clinical chapters examine the role of thrombosis prophylaxis and treatment, central line-associated thrombosis, and cancer-associated hemorrhage. Subsequent chapters deal with the management of chemotherapy-induced thrombocytopenia, anticoagulation in the presence of brain metastases, and other unique challenges in the interaction of thrombosis and hemostasis in cancer. It has been 150 years since Armand Trousseau first described the well-known association between cancer and an increased risk of thrombosis, which may be considered the first paraneoplastic syndrome ever identified. More recently, numerous studies have indicated that activation of the coagulation system by cancer not only increases the likelihood of thrombosis, but is also associated with a more aggressive cancer phenotype. By familiarizing readers with the latest developments in this complex and challenging field, the book offers a valuable resource for scientists and clinicians alike.

Summary: The thymus is an evolutionarily ancient primary lymphoid organ common to all vertebrates in which T cell development takes place. Failing thymus function is associated with immunodeficiency and/or autoimmunity. In this volume, leading experts provide a comprehensive overview of recent advances in thymopoiesis research. The chapters cover the development of the thymic epithelial microenvironment, address the formation of a diverse and self-tolerant repertoire of T cell receptors as the basis for cellular immunity, discuss the mechanisms by which progenitor cells colonize the thymus and detail the molecular basis for T lineage decisions. The reviews illustrate the important role of the multifaceted process of thymopoiesis for adaptive immunity.

Contents:
Development and Function of Cortical Thymic Epithelial Cells
Mechanisms of Thymus Medulla Development And Function
Self-peptides in TCR Repertoire Selection and Peripheral T Cell Function
Central Tolerance Induction
Trafficking to the Thymus
The CD4/CD8 Lineages: Central Decisions and Peripheral Modifications for T Lymphocytes.

Summary: This volume focuses on challenging field in biomedicine that is the genetic control of central immune tolerance. It covers the thymus development, their cellular components and their respective function, the peculiar gene expression profiling (transcriptome) found in the medullary thymic epithelial cells (mTECs) that are implicated in the self-representation in the thymus, the Autoimmune regulator (Aire) gene, the mutations in this gene and manifestation of autoimmune diseases, and the role of cell-cell interactions within the thymus with implications in the negative selection (elimination) of nascent autoreactive T cells in preventing aggressive autoimmunity. The thymus gland is a lymphoid organ implicated in the maturation, differentiation and selection of T cells. This organ is gained more and more attention in different biomedical research labs worldwide due to its function that is associated with the control of immune homeostasis in the body, establishing the central immune tolerance and preventing the onset of autoimmune diseases.

Contents:
1. History of the thymus: From a vestigial organ to the programming of immunological self-tolerance
2. Thymus Ontogeny and Development
3. The Ins and Outs of Thymic Epithelial Cell Differentiation and Function
4. T-Cell Development: From T-Lineage Specification to Intrathymic Maturation
5. Intrathymic cell migration: implications in thymocyte development and T-cell repertoire formation
6. Thymic crosstalk: an overview of the complex cellular interactions that control the establishment of T-cell tolerance
7. The Autoimmune Regulator (AIRE) gene, the master activator of self-antigen expression in the thymus
8. Aire Mutations and Autoimmune Diseases
9. The thymus as a mirror of the body's gene expression
10. Functional genomics of the infant human thymus: Aire and minipuberty
11. Thymus transcriptome of TGF-β superfamily
12. Development of thymic regulatory T lymphocytes
13. Adding insult to injury: improving the regenerative capacity of the aged thymus following clinically induced damage
14. Thymus rejuvenation after autologous hematopoietic stem cell transplantation in patients with autoimmune diseases.

Summary: This book will provide readers with up-to-date information on thyroid diseases, obesity and metabolic syndrome. The innovative element is the presentation and exploration of possible connections linking thyroid diseases and metabolism dysfunction. Starting from the classification and diagnosis of thyroid diseases, obesity and metabolic syndrome, techniques to study and treat each of the mentioned diseases are given in an easy-to-use way. This volume will be a useful tool for endocrinologists, diabetologists, dieticians, and any professionals involved in the treatment of thyroid diseases.

Contents:
PART I THYROID: Thyroid gland: anatomy and physiology
Classification of thyroid diseases
Iodine deficiency and thyroid dysfunction
Techniques to study thyroid function and morphology
Medical and surgical treatment
PART II OBESITY and METABOLIC SYNDROME: Obesity and metabolic syndrome: the new pandemic
Classification and diagnosis
Medical and surgical treatment
Techniques to study metabolism
PART III THYROID, METABOLISM and OBESITY: Link between thyroid dysfunction and metabolic syndrome
Muscle tissue and hypothyroidism
Thyroid function and effects on cardiovascular system
Obesity, adipokines and thyroid dysfunction
Adipokines and thyroid malignancies
Link between thyroid tumors and metabolism
PART IV CLINICAL CASES.

Summary: In recent years, several scientific papers have highlighted the role of the thyroid system in cardioprotection, and several clinical studies - including multicenter studies - have identified the role of thyroid hormones (TH) in the development and progression of cardiovascular disease, making an update of TH and heart relationship both necessary and timely. This second edition of Thyroid and Heart failure provides a careful and updated review of the experimental, clinical and epidemiological results in the field of TH and heart failure, with a particular focus on the translational - bench to bedside - significance of the obtained results. It discusses topics such as the molecular, structural, functional, cellular and histological cardiac changes; the reversibility of these changes with TH replacement therapy; the systemic effects - kidney, hormonal pathways systems, brain, muscle, etc - of altered TH metabolism in HF, as well as the clinical and prognostic implications. The section devoted to the potential therapeutic treatments has been expanded. Thanks to its translational approach to this highly complex subject, the book will be of interest to a broad readership, including cardiologists, endocrinologists and internists. .

Contents:
Intro
Foreword
Foreword: Thyroid and the Heart: A Roadmap
Preface
Contents
Part I: Heart and Thyroid: Historical and Basic Aspects
1: Thyroid and the Heart: A Historical Perspective
1.1 Heart Thyrotoxicosis
1.2 Myxedema Heart
References
2: Physiological Role of Thyroid Hormone in the Developing and Mature Heart
2.1 Introduction
2.2 Membrane Transport
2.3 Metabolism
2.4 Effect of Thyroid Hormone in Heart Development
2.5 Effect of Thyroid Hormone in the Mature Heart
2.6 Conclusions
References 3: Thyroid Hormone Signaling Mechanisms in the Heart and Vasculature
3.1 TH Signaling Through Nuclear TRs
3.2 TR Isoforms
3.3 Cellular Localization of TRs
3.4 Posttranslational Modification of TRs
3.5 Genes Regulated by THs
3.5.1 Cardiomyocyte Calcium Transients and Contractility
3.5.2 Transverse-Tubules
3.5.3 Metabolism and Mitochondria
3.6 TH Signaling Through Cytosolic TRs
3.7 Vascular Responses to TH
3.7.1 Angiogenesis and Vascular Remodeling
3.8 TH Effects Independent of TRs
3.8.1 TH Activation of Ion Channels
3.9 Conclusions 5: Diastolic and Systolic Dysfunction of the Heart and Thyroid Hormone Abnormalities
5.1 Mechanism of Action of Thyroid Hormone on Myocardium
5.2 Hyperthyroidism and Cardiac Dysfunction
5.3 Effects of Overt Hypothyroidism on Cardiac Function
5.4 Action of Subclinical Hypothyroidism
5.4.1 Cardiac Function at Rest and During Exercise in Subclinical Hypothyroidism
5.4.2 Peripheral Vascular Abnormalities in Subclinical Hypothyroidism
5.5 Action of Low T3 Syndrome
5.6 Beneficial Effects of Thyroid Hormone Treatment
References Part III: Thyroid System in CV Diseases in Experimental Models
6: TH Metabolism in Ischemia/Reperfusion Models
6.1 Introduction
6.2 Overview of Thyroid Hormones and Receptors
6.3 Thyroid Hormone Metabolism
6.3.1 Deiodination Pathways
6.3.2 Alternative Pathways
6.4 Effect of TH Dysfunction on CVD and Vice Versa
6.5 Cardioprotection by TH in Ischemia: A Lesson From Experimental Models
6.6 Conclusions
References
7: Thyroid Hormone Deiodinative Pathways in the Normal and Failing Heart
7.1 Introduction

Summary: This book is an up-to-date and comprehensive guide to all the common thyroid disorders that may be seen by internists, endocrinologists, nuclear medicine physicians, and endocrine surgeons. While the fundamentals of thyroid hormone function and regulation in health and disease are well covered, the primary focus is on the clinical approach to thyroid disease, with detailed coverage of both initial diagnosis and management and the role of imaging. Because most endocrine diseases are chronic and lifelong, special emphasis is placed on long-term management and the common pitfalls that may be encountered by the clinician. The editors are internationally acknowledged leaders in the field of thyroid disease and have gathered an outstanding team of authors, all of whom are also highly expert in their respective areas, but who, equally importantly, write in a clear and lucid style. The numerous isotope scan and ultrasonographic images ensure that the book will serve as a valuable reference atlas to which the physician will return again and again. .

Contents:
Part I: Introductory Section - Part II. Basis of Thyroid Disease - Part III. Diagnostic and Therapeutic Approaches - Part IV. Hypothyroidism - Part V. Hyperthyroidism - Part VI. Thyroiditis - Part VII. Thyroid Neoplasia - Part VIII. Thyroid Cancer - Part IX. Miscellaneous Topics.

Summary: Now in its second edition utilizing brand new clinical case material, this popular, user-friendly text presents the diagnosis and treatment of thyroid cancer and related clinical issues, providing clinicians in endocrinology and oncology with the best real-world strategies to properly manage the various manifestations of thyroid cancer that they may encounter. Each chapter is a case report that opens with a unique clinical presentation, followed by a description of the diagnosis, assessment and therapy, as well as the case outcome, literature review, clinical pearls and pitfalls, and bibliography. All recommendations are based on evidence-based clinical practice guidelines and recent literature. Written by experts in the field, these cases illustrate treatment for both low- and high-risk differentiated thyroid cancer, including surgical approaches, radioiodine therapy, and novel chemotherapies and targeted therapies, as well as postoperative follow-up and special issues. Additional cases demonstrate the management of medullary thyroid cancer and anaplastic thyroid cancer. Topics new to the second edition include information on management of small thyroid cancers with "active surveillance" (without surgery), new chemotherapeutic approaches to advanced thyroid cancer, and new information on a lesion that is no longer considered to be thyroid cancer (Neoplastic Follicular Thyroid Neoplasm with Papillary-Like Features [NIFTP]), as well as material on external beam radiotherapy and new approaches to the management of anaplastic thyroid cancer. Pragmatic and reader-friendly, this second edition of Thyroid Cancer: A Case-Based Approach will be an excellent resource for clinical endocrinologists and oncologists, endocrine fellows, residents and students alike

Summary: Thyroid Cancer and Nuclear Accidents: Long-Term Aftereffects of Chernobyl and Fukushima discusses the radiobiological effects of the release of radioiodine from two nuclear power plant accidents and appropriate interpretation of the results of thyroid ultrasound examination. The book pulls together expert opinion on radiation related thyroid cancer in an understandable manner, even for non thyroidologists. The book explains what has been learned from both accidents in relation to prevention of thyroid cancer following nuclear power plant accidents. The book encompasses topics such as risk estimations of thyroid cancer following nuclear accidents and clinical aspects after those specific situations. Additionally, it discusses in detail the reports from Fukushima related to thyroid cancer in the population. This book is a valuable resource for oncologists and biomedical researchers with interest in nuclear accidents and cancer cases.

Contents:
Section 1. Lessons from Chernobyl: an Examination of Radiation Risks, Based on International Consensus and Evidence Related to Thyroid Cancer, 30 Years after
Section 2. Thyroid Cancer: The Reality of Chernobyl
Section 3. Thyroid Cancer: Questions for Fukushima
Section 4. From Chernobyl to Fukushima

Summary: This volume presents and analyses the ongoing arguments, controversies, challenges and debates on thyroid disease with a view to clarifying some uncertainties, and to making suggestions that will help resolve others. Issues such as thyroid disease during pregnancy, Hashimotos disease, Hurthle cell lesions, solitary thyroid nodules, retrosternal goiter, thyroid cancer, recurrent thyroid disease, thyroidectomy techniques, post-thyroidectomy hypocalcemia, and thyroid auto-transplantation are thoroughly explored. Richly illustrated, the book offers an invaluable tool for all specialists and trainees entrusted with the care of patients suffering from thyroid disease.

Contents:
Intro
Preface
Acknowledgments
Contents
1: Thyroid Disease During Pregnancy
1.1 Introduction
1.2 Physiological Changes During Pregnancy
1.3 Thyroid Function Tests in Pregnancy
1.3.1 How Do Thyroid Function Tests Change During Pregnancy?
1.3.2 What Is the Normal Range for TSH in Each Trimester?
1.3.3 Recommendations [8]
1.4 Screening for Maternal Thyroid Dysfunction
1.4.1 Introduction
1.4.2 Screening for Thyroid Dysfunction
1.4.3 Efficacy of Case Finding
1.4.4 Thyroid Screening in Pregnancy: Current Practice and Cost-Effectiveness 1.4.5 Recommendations
1.4.6 Conclusion
1.5 Iodine Deficiency During Pregnancy
1.5.1 Requirement of Iodine During Pregnancy and Lactation
1.5.1.1 Increase in T4 Requirements
1.5.1.2 Transfer of T4 and Iodide from Mother to Fetus
1.5.1.3 Increased Renal Clearance of Iodide
1.5.1.4 Level of Urinary I2 Indicating Optimal I2 Nutrition During Pregnancy and Lactation
1.5.2 Requirement of Iodine in Neonates
1.5.2.1 Level of Urinary I2 Indicating Optimal I2 Nutrition in Neonates
1.5.3 Conclusion
1.5.4 Recommendations [8]
1.6 Hyperthyroidism in Pregnancy 1.6.1 Definitions
1.6.2 Causes of Thyrotoxicosis
1.6.3 Diagnosis of Hyperthyroidism in Pregnancy
1.6.4 Risks of Hyperthyroidism During Pregnancy on Fetal and Maternal Health
1.6.5 Treatment of Hyperthyroidism During Pregnancy
1.6.5.1 Caveats and Goals of Antithyroid Drug Treatment
1.6.6 Treatment of Hyperthyroidism During the Post-partum Period
1.6.7 Recommendations [116, 135, 137, 138]
1.7 Hypothyroidism in Pregnancy
1.7.1 Iodine Deprivation and Goiter Formation
1.7.2 Overt or Subclinical Hypothyroidism?
1.7.3 Isolated Hypothyroxinemia 1.7.4 Incidence of Hypothyroidism During Pregnancy
1.7.5 Risks of Hypothyroidism on Fetal and Maternal Health
1.7.6 Treatment of Hypothyroidism During Pregnancy
1.7.6.1 Effectiveness of Levothyroxine Treatment
1.7.6.2 Caveats of Levothyroxine (LT4) Treatment During Pregnancy
1.7.7 Treatment of Hypothyroidism During the Post-partum Period
1.7.8 Recommendations [8, 197]
1.8 Autoimmune Thyroiditis in Pregnancy
1.8.1 Incidence
1.8.2 Risks on Fetal and Maternal Health
1.8.3 Treatment
1.8.4 Recommendations [8] 1.9 Infertility and Miscarriage: Impact of Thyroid Dysfunction
1.9.1 Introduction
1.9.2 Autoimmunity and Reproductive Failure
1.9.3 Impact of TAI on Infertility
1.9.4 Impact of TAI on Miscarriage
1.9.4.1 Classical Studies
1.9.4.2 Assisted Reproductive Techniques (ARTs) and Miscarriage
1.9.4.3 Effect of Thyroxine Administration on Miscarriage in Women with Positive Thyroid Abs
1.9.5 Conclusions
1.10 Post-partum Thyroiditis
1.10.1 Definition
1.10.2 Incidence
1.10.3 Clinical Evaluation and Treatment
1.10.4 Recommendations [8]

Summary: This book presents the latest advances in knowledge of the pathogenesis of thyroid diseases and describes the state of the art in their diagnosis and treatment, including newly emerging management approaches. After an opening section that addresses thyroid physiology and laboratory evaluation, each of the major thyroid diseases and their subtypes is discussed, covering goiter and thyroid nodule, thyroiditis, hypothyroidism, hyperthyroidism and thyrotoxicosis, and thyroid carcinoma. Other conditions that affect thyroid function or induce thyroid dysfunction are also considered, e.g., pregnancy, non-thyroidal disorders, and medication use. The book is designed to assist practitioners to achieve optimal outcomes in clinical routine by providing clear guidance on clinical examination, the use of diagnostic tests, first- and second-line therapies, and follow-up. Chapter have been written by recognized experts in the field.

Contents:
Part I Thyroid physiology and laboratory evaluation of the thyroid: Regulation of thyroid function, synthesis and function of thyroid hormones
Tests of thyroid function
Thyroid autoantibodies
Thyroid imaging
Part II Goiter and thyroid nodule: Non-toxic goiter
Thyroid nodule
Part III Thyroiditis: Hashimoto's thyroiditis
Post-partum thyroiditis and silent thyroiditis
Acute and sub-acute thyroiditis
Part IV Hypothyroidism: Classification and etiopathogenesis
Congenital hypothyroidism
Primary hypothyroidism
Central hypothyroidism
Diagnosis and treatment of hypothyroidism
Part V Hyperthyroidism and thyrotoxicosis: Graves' disease
Graves' ophthalmopathy
Treatment of Graves' disease
Toxic adenoma and multinodular toxic goiter
Other forms of thyrotoxicosis
Part VI Thyroid carcinoma: Pathogenesis of thyroid carcinoma
Differentiated thyroid carcinoma of follicular origin
Medullary carcinoma
Anaplastic and other forms of thyroid carcinoma
New (medical) treatment for thyroid carcinoma
Part VII Other conditions influencing thyroid function or inducing thyroid dysfunction: Thyroid physiology and thyroid diseases in pregnancy
Non-thyroidal illness
Drugs and other substances interfering with thyroid function and inducing thyroid diseases.

Summary: This book covers the entire spectrum of thyroid diseases in childhood, focusing on the recent advances that have been achieved, from progress in basic science research through to novel or improved approaches to diagnosis and treatment. Introductory chapters discuss thyroid embryogenesis and the role of thyroid hormones in fetal development. The two contrasting forms of thyroid dysfunction, hypo- and hyperthyroidism, are then considered in depth, with particular attention to the molecular causes of congenital hypothyroidism. Among the other topics addressed are autoimmune thyroiditis, thyroid nodules, and pediatric neoplasms. The book concludes with an overview of promising therapeutic approaches, such as stem cell therapy. Each topic is treated by an eminent expert in the field, ensuring consistently high quality. Thyroid Diseases in Childhood will be an important source of information for endocrinologists, pediatricians, oncologists, and gynecologists, as well as other professionals interested in this topic.

Contents:
Thyroid embryogenesis
Thyroid hormones in fetal development
Etiology of congenital hypothyroidism
Neonatal screening for congenital hypothyroidism: what it has taught us about thyroid and brain
Laboratory aspects in neonatal screening of congenital hypothyroidism
Epidemiology of congenital hypothyroidism
Congenital hypothyroidism due to PAX8 mutations
Transient neonatal hypothyroidism
Central Hypothyroidism
Syndromes of resistance to thyroid hormone action
Management of congenital hypothyroidism
Neurodevelopmental outcomes in children with congenital hypothyroidism
Iodine deficiency from pregnancy to childhood
Thyroid enlargement from newborn to adolescent
Thyroid nodules and carcinoma
Autoimmune thyroiditis
Subclinical hypothyroidism
Hyperthyroidism
Generation of functional thyroid from embryonic stem cells.

Summary: This book provides a comprehensive overview of various thyroid disorders in pregnancy. Merging clinical evidence with their own professional experience, international experts in the field report on novel research and share insights on a broad range of topics, from addressing the normal physiology of the thyroid in pregnancy, to the safe treatment of disorders during pregnancy. Given its scope, the book is chiefly intended for internists, obstetricians, gynecologists, endocrinologists and related sub-specialists; however, it will also benefit general physicians.

Contents:
Thyroid function in pregnancy
Iodine Nutrition in Pregnancy
Screening of thyroid Function
Preconception Counseling
Abnormalities of Maternal Thyroid Function
Autoimmune Thyroid Disease and Pregnancy,. Nodular Thyroid Disease in pregnancy
Postpartum Thyroid Disease
Thyroid and Infertility
Thyroid Disorders & Contraception.

Summary: This comprehensive book provides core understanding and clinical knowledge to all those involved in managing thyroid disorders. The authors examine the basic thyroid glandular functions which are essential in understanding the pathophysiology and clinical aspects of this disease. The chapters present recent trends, technologies and advancements in the management of thyroid diseases to help readers keep abreast of modern thyroid disease management. Some special and important issues such as pregnancy and thyroid diseases, psychiatric disorders and thyroid, and subclinical thyroid dysfunctions are also included. Thyroid Disorders - Basic Science and Clinical Practice is aimed at physicians, endocrinologists, endocrine surgeons and general surgeons with special interest in thyroid management, as well as dieticians, researchers and medical students at all levels.

Contents:
Fundamental concepts
Throid dysfunction and clinical application
Pregnancy and throid dysfunction.

Summary: This book offers ophthalmologists and medical practitioners a concise, data-driven review of the information that is most relevant in guiding the diagnosis and management of thyroid eye disease (TED). Particular attention is devoted to research and clinical trials that have advanced the field in recent years. Progress in our understanding of the pathogenesis of TED is described, and the heterogeneous natural history of TED is discussed to facilitate preemptive interventions. Advances in diagnostic evaluation, including autoantibody assessment, are reviewed with regard to their clinical utility. The diagnostic features of euthyroid TED are also carefully covered since these patients often represent a diagnostic dilemma. All relevant aspects of treatment are addressed including the role of radioactive iodine, long-term medical therapy, and surgical thyroidectomy. The impact of these treatment modalities on eye disease are discussed. Management of active TED is reviewed according to the severity of disease and in the light of recent findings and the introduction of novel agents. The discussion encompasses the role of steroids and other agents, the use of novel biologics, the medical and surgical treatment of optic neuropathy, and minimally invasive, customized reconstructive surgery. Numerous supporting images are included, and helpful checklists will aid the practitioner in treatment decision making.

Summary: This book offers a comprehensive guide to thyroid fine needle aspiration (FNA) cytology. Borderline/precursor tumors, which were introduced in the 4th edition of the WHO classification of thyroid tumors, are also incorporated. In this second edition, prominent international experts discuss the different approaches to thyroid FNA cytology employed in various countries such as Australia, Canada, China, Korea, Portugal, Switzerland, Taiwan, Thailand, Turkey, Ukraine, the USA, UK, Italy and Japan. The book not only covers key principles of thyroid cytopathology but also addresses technical aspects such as procedural complications, liquid-based cytology, immunocytochemistry, staining procedures, and potential pitfalls. Case-based descriptions and clinical findings, radiologic imaging, cytology, and histopathologic diagnosis - all complemented by a wealth of detailed photographs - will help reader understand and overcome many common dilemmas in daily practice. As such, the book represents an indispensable reference work for all cytopathologists, especially those practicing thyroid cytopathology. .

Summary: Utilizing the most current evidence, this practical book is the first publication of its kind to focus exclusively on the clinical and laboratory evaluation and therapy of thyroid nodules, including advances in evaluation and controversies in management. Opening with chapters presenting the epidemiology, history, laboratory and clinical evaluation of thyroid nodules, the use of radioactive isotope ultrasound and CT scanning in diagnosis is then described. The interpretation of thyroid cytology following fine needle aspiration (FNA) biopsies and the use of molecular markers are discussed in detail, as is the controversial use of thyroxine therapy. Following a presentation of the common and minimally invasive surgical approaches to thyroid nodules, chapters on multinodal goiters, incidentalomas and thyroid nodules in children round out the presentation. Written and edited by leading US and international thyroidologists, Thyroid Nodules is a useful, state-of-the-art text for endocrinologists, surgeons, and primary care physicians.

Contents:
Epidemiology of Thyroid Nodules
History and Examination for Thyroid Nodules
Laboratory Evaluation for Thyroid Nodules
Nuclear Medicine in Evaluation and Therapy of Nodular Thyroid
Imaging for Thyroid Nodules
Fine Needle Aspiration for Thyroid Nodules
Description and Classification of Thyroid Cytology
Molecular Markers and Thyroid Nodule Evaluation
Thyroxine Therapy for Thyroid Nodules
Multinodular Goiter
Thyroid Incidentalomas
Surgery for Thyroid Nodules
Minimally-Invasive Treatments for Thyroid Nodules
Thyroid Nodules in Children.

Summary: This book is a wide-ranging and up-to-date guide to the use of ultrasound for imaging of the thyroid that will meet the needs of novices while providing more experienced professionals with advanced information. All of the techniques employed in modern thyroid ultrasound are covered, from conventional grayscale and Doppler imaging to elastography and contrast-enhanced ultrasound, with a focus on practical aspects and with detailed analysis of their diagnostic value and limitations. The characteristic ultrasound findings of the normal thyroid and a wide range of thyroid diseases and disorders are described with the aid of hundreds of high-quality images. Diffuse changes and thyroid lesions are discussed in depth, paying close attention to aspects of importance for early detection and differential diagnosis. In this context the authors summarize their personal experiences in the use of qualitative parameters of compression elastography and quantitative data of shear-wave elastography. In addition, a practical approach to the risk stratification of thyroid nodules is proposed. The book concludes with a resumé of the main challenges and pitfalls in thyroid ultrasound.

Contents:
1. Current State of the Problem of Thyroid Diseases
2. Principles and Technology of Thyroid Ultrasound
3. Ultrasound Image of the Normal Thyroid Gland
4. Congenital Thyroid Anomalies and Thyroid Diseases in Children
5. Ultrasound Diagnosis in Diffuse Thyroid Diseases
6. Ultrasound Diagnosis in Thyroid Lesions
7. Ultrasound of the Parathyroid Glands and Neck Masses
8. Neck Ultrasound after Thyroid Surgery
9. Thyroid Disorders and Female Reproductive System Diseases. The Thyroid Gland and Pregnancy
10. Ultrasound of Neck Lymph Nodes
11. Ultrasound-Guided Fine Needle Aspiration Biopsy
12. Main Challenges and Pitfalls in Thyroid Ultrasound
13. Conclusion.

Contents:
History of transient ischemic attack definition / Mohr, J.P.
The concept of acute cerebrovascular syndrome / Uchiyama, S.
Transient ischemic attack as a medical emergency / Okada, Y.
TIA clinic : a major advance in management of transient ischemic attacks / Lavalle, P.; Amarenco, P.
Risk scores for transient ischemic attack / Wolf, M.E.; Held, V.E.; Hennerici, M.G.
Epidemiology of transient ischemic attack / Kokubo, Y.
Symptoms of transient ischemic attack / Kim, J.S.
Guidelines for management of patients with transient ischemic attack / Uehara, T.; Minematsu, K.
Radiological examinations of transient ischemic attack / Tung, C.E.; Olivot, J.M.; Albers, G.W.
Neurosonological examinations of transient ischemic attack / Sharma, V.K.; Wong, K.S.L.
Stroke subtypes and interventional studies for transient ischemic attack / Lavalle, P.; Amarenco, P.
Antithrombotic therapy in transient ischemic attack patients / Held, V.E.; Wolf, M.E.; Hennerici, M.G.

Summary: "Tibial Plateau Fractures has been written to provide a single text that covers every aspect of treatment of these complex fractures with a focus on practical clinical knowledge. Modern treatment strategies have been clearly defined based on recent literature and cutting-edge fixation techniques. Case examples and high yield points are highlighted at the end of every chapter in order to help the reader come away with the most crucial aspects of care as determined by the surgeon experts who have authored each chapter. Reduction techniques for percutaneous and open surgical treatment of these fractures has been emphasized. Additionally, an entire chapter has been devoted to soft tissue injuries that occur in conjunction with tibial plateau fractures. This is an important distinction from other books, chapters, and journal articles, on the subject, as soft tissue injuries are often overlooked in prior works with a focus on the bony injury only. Untreated soft tissue injuries can be a source of long-term disability and poor outcomes in these multifaceted injuries. This book intends to help the reader identify all aspects of care in the treatment of tibial plateau fractures and help the surgeon to achieve the best possible outcome." -- from preface.

Summary: TIMBER psychotherapy is a novel, translational and biomarker informed, mindfulness-based cognitive behavioral therapy approach that addresses some of the current treatment gaps for PTSD, depression and traumatic psychosis. This treatment manual offers practitioners and patients alike a step-by-step guide to TIMBER (acronym for Trauma Interventions using Mindfulness Based Extinction and Reconsolidation of memories) psychotherapy, and has been divided into four parts: Understanding Complex Trauma and Traumatic Psychosis; Methodology and Application; Training Professionals; and Policy Implications & Future Research Directions. In addition to a strong rationale and evidence base for the TIMBER approach, the book also provides case examples accompanied by videos (available separately). Its special features include reproducible client handouts, assessment tools, and a list of resources for training to use TIMBER.

Contents:
Part-I: Understanding Complex Trauma and Traumatic Psychosis: Complex traumatic memories and spectrum of their manifestation
Traumatic experiences and memories
TIMBER as a novel psychotherapy for PTSD, traumatic psychosis and related conditions
Part-II: Methodology and Applications of TIMBER: Notes on the Assessment Tools used in TIMBER
The Nuts and Bolts of TIMBER Psychotherapy & Case Based Illustrations,
Part-III: Training the Professionals, Policy Implications, Directions for Future Research and Concluding Statements: Cultural considerations in application of TIMBER
Therapist training on TIMBER and policy implications
Adapting TIMBER to clients in specific settings
Concluding Remarks & Resources.

Summary: The Present, Past, and Future of Timbre Research Kai Siedenburg, Charalampos Saitis, and Stephen McAdams The Perceptual Representation of Timbre Stephen McAdams Timbre Recognition and Sound Source Identification Trevor R. Agus, Clara Suied, and Daniel Pressnitzer Memory for Timbre Kai Siedenburg and Daniel Müllensiefen The Semantics of Timbre Charalampos Saitis and Stefan Weinzierl Neural Correlates of Timbre Processing Vinoo Alluri and Sudarsana Reddy Kadiri Voice Processing and Voice-Identity Recognition Samuel Robert Mathias and Katharina von Kriegstein Timbre as a Structuring Force in Music Stephen McAdams Timbre, Sound Quality, and Sound Design Guillaume Lemaitre and Patrick Susini Timbre Perception with Cochlear Implants Jeremy Marozeau and Wiebke Lamping Audio Content Descriptors of Timbre Marcelo Caetano, Charalampos Saitis, and Kai Siedenburg Modulation Representations for Speech and Music Mounya Elhilali Timbre from Sound Synthesis and High-level Control Perspectives Sølvi Ystad, Mitsuko Aramaki, and Richard Kronland-Martinet Kai Siedenburg is Marie Sklodowska-Curie Individual Postdoctoral Fellow in the Department of Medical Physics and Acoustics at the Carl von Ossietzky Universität Oldenburg, Germany Charalampos Saitis is Lecturer and Humboldt Research Fellow in the Audio Communication Group at Technische Universität Berlin, Germany Stephen McAdams is Professor and Canada Research Chair in Music Perception and Cognition in the Department of Music Research at McGill University, Montreal, Canada Arthur N. Popper is Professor Emeritus and research professor in the Department of Biology at the University of Maryland, College Park Richard R. Fay is Distinguished Research Professor of Psychology at Loyola University, Chicago.

Contents:
Intro; Acoustical Society of America; Series Preface; Springer Handbook of Auditory Research; Preface 1992; Volume Preface; Contents; Contributors;
Chapter 1: The Present, Past, and Future of Timbre Research; 1.1 Timbre As a Research Field; 1.1.1 Inter-Disciplinary Perspectives; 1.1.2 Defining a Complex Auditory Parameter; 1.2 Milestones in Timbre Research; 1.2.1 Fourier and Helmholtz; 1.2.2 Timbre Spaces; 1.2.3 Verbal Attributes; 1.2.4 Recognition of Sound Sources and Events; 1.2.5 High-Dimensional Acoustic and Neuromimetic Representations; 1.2.6 Neural Correlates of Timbre Processing 1.3 Structure and Content of Volume1.3.1 Roadmap of Chapters; 1.3.2 Future Perspectives; References; Part I: Principal Perceptual Processes;
Chapter 2: The Perceptual Representation of Timbre; 2.1 Introduction; 2.2 Timbre Discrimination; 2.3 Multidimensional Conceptions of Timbre; 2.3.1 Multidimensional Scaling Models; 2.3.2 Timbre Spaces; 2.3.3 Acoustic Correlates of Timbre Space Dimensions; 2.4 Spectromorphological Conceptions of Timbre; 2.4.1 The Auditory Image Model; 2.4.2 Multiresolution Spectrotemporal Models; 2.5 Sound Source Perception; 2.5.1 Sound Source Geometry 2.5.2 Sound Source Materials2.5.3 Actions on Vibrating Objects; 2.6 Interaction with Other Auditory Attributes; 2.6.1 Timbre and Pitch; 2.6.2 Timbre and Playing Effort (Dynamics); 2.7 Summary and Conclusions; References;
Chapter 3: Timbre Recognition and Sound Source Identification;
Chapter 4: Memory for Timbre; 4.1 Introduction; 4.2 Auditory Memory Concepts; 4.2.1 Stores and Processes; 4.2.2 Granularity of Auditory Memory; 4.2.3 Capacity Limits in Short-Term Memory; 4.3 Factors in Short-Term Recognition; 4.3.1 Memory Capacity and Similarity; 4.3.2 Sequential Chunking 4.4 Active Maintenance and Imagery of Timbre4.4.1 Maintenance in Working Memory; 4.4.2 Mental Imagery of Timbre; 4.5 Interference Effects in Memory for Timbre; 4.5.1 Interference in Short-Term Memory; 4.5.2 Timbre and Long-Term Melodic Memory; 4.5.3 Timbre and Verbal Memory; 4.6 Familiarity and Voice Superiority; 4.6.1 Familiarity in Short-Term Recognition; 4.6.2 Voice Superiority; 4.7 Summary and Future Perspectives; 4.7.1 Principles of Memory for Timbre; 4.7.1.1 Integration: Timbre Information as Integrated Representations in Memory 4.7.1.2 Grouping: Memory for Timbre Sequences is Affected by Grouping Cues4.7.1.3 Familiarity: Better Memory Performance and Processing Accuracy; 4.7.1.4 Perceptual Simulation: Active Memory Rehearsal and Timbre Imagery; 4.7.1.5 Matching: Timbre Recognition via Similarity-Based Matching; 4.7.2 Future Perspectives; References;
Chapter 5: The Semantics of Timbre;
Chapter 6: Neural Correlates of Timbre Processing; 6.1 Introduction; 6.1.1 Levels of Abstraction; 6.1.2 Hierarchical Processing; 6.1.3 Types of Stimuli; 6.1.4 Measurement Modalities and Modeling Approaches of Brain Activity