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  • 2007 Springer
    U. Bastolla ... [et al.] (eds.).
    Modeling conformational flexibility and evolution of structure : RNA as an example / P. Schuster and P.F. Stadler -- Gene3D and understanding proteome evolution / J.G. Ranea ... [et al.] -- The evolution of the globins : we thought we understood it / A.M. Lesk -- The structurally constrained neutral model of protein evolution / U. Bastolla ... [et al.] -- Towards unifying protein evolution theory / N.V. Dokholyan and E.I. Shakhnovich -- A twenty-first century view of evolution : genome system architecture, repetitive DNA, and natural genetic engineering / J.A. Shapiro -- Genomic changes in bacteria : from free-living to endosymbiotic life / F.J. Silva ... [et al.] -- Molecular phylogenetics : mathematical framework and unsolved problems / X. Xia -- Phylogenetics and computational biology of multigene families / P. Liò, M. Brilli and R. Fani -- SeqinR 1.0-2 : a contributed package to the R project for statistical computing devoted to biological sequences retrieval and analysis / D. Charif and J.R. Lobry -- Evolutionary genomics of gene expression / I.K. Jordan and L. Mariño-Ramírez -- From biophysics to evolutionary genetics : statistical aspects of gene regulation / M. Lässig -- Drift and selection in evolving interacting systems / T. Ohta -- Adaptation in simple and complex fitness landscapes / K. Jain and J. Krug -- Genetic variability in RNA viruses : consequences in epidemiology and in the development of new strategies for the extinction of infectivity / E. Lázaro.
  • 2005/2006
    Stephen E. Kaiser.
    Status: Not Checked OutLane Catalog Record
  • 2005 CRCnetBASE
    edited by Dimitrios Morikis, John D. Lambris.
  • 2009
    Juan José Fung.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer Protocols
    edited by Yu Wai Chen.
    1. DisMeta : a meta server for construct design and optimization / Yuanpeng Janet Huang, Thomas B. Acton, and Gaetano T. Montelione -- 2. Stable expression clones and auto-induction for protein production in E. coli / F. William Studier -- 3. High-throughput expression screening and purification of recombinant proteins in E. coli / Natalie J. Saez and Renaud Vincentelli -- 4. Medium-throughput production of recombinant human proteins : ligation-independent cloning / Claire Strain-Damerell, Pravin Mahajam, Opher Gileadi and Nicola A. Burgess-Brown -- 5. Medium-throughput production of recombinant human proteins : protein production in E. coli / Nicola A. Burgess-Brown, Pravin Mahajan, Claire Strain-Damerell, Opher Gileadi and Susanne Gräslund -- 6. Medium-throughput production of recombinant human proteins : protein production in insect cells / Pravin Mahajan , Claire Strain-Damerell, Opher Gileadi and Nicola A. Burgess-Brown -- 7. OmniBac : universal multigene transfer plasmids for baculovirus expression vectors systems / Deepak B. Thimiri Govinda Raj, Lakshmi S. Vijayachandran, and Imre Berger -- 8. Multiprotein complex production in insect cells by using polyproteins / Yan Nie, Itxaso Bellon-Echeverria, Simon Trowitzch, Christoph Bieniossek and Imre Berger -- 9. Expression screening in mammalian suspension cells / Susan D. Chapple and Michael R. Dyson -- 10. Cell-free expression of protein complexes for structural biology / Takaho Terada, Takehi Murata, Mikako Shirouzu and Shigeyuki Yokoyama -- 11. Cell-free protein synthesis for functional and structural studies / Shin-ichi Makino, Emily T. Beebe, John L. Markley and Brian G. Fox -- 13. Insoluble protein purification with sarkosyl : facts and precautions / Ben Chisnall, Courtney Johnson, Yavuz Kulaberoglu and Yu Wai Chen -- 13. Estimation of crystallization likelihood through a fluorimetric thermal stability assay / Vincent Mariaule, Florine Dupeux, and José A. Márquez -- 14. CrystalDirect : a novel approach for automated crystal harvesting based on photoablation of thin films / José A. Márquez and Florent Cipriani -- 15. Methods to refine macromolecular structures in cases of severe diffraction anisotropy / Michael R. Sawaya -- 16. Applications of NMR-based PRE and EPR-based DEER spectroscopy to homodimer chain exchange characterization and structure determination / Yunhuang Yang, Theresa A. Ramelot, Shuisong Ni, Robert M. McCarrick and Michael A. Kennedy -- 17. Cost-effective protocol for the parallel production of libraries of 13CH3-specifically labeled mutants for NMR studies of high molecular weight proteins / Elodie Crublet, Rime Kerfah, Guillaume Mas, Marjolaine Noirclerc-Savoye, Violaine Lantez, Thierry Vernet and Jerome Boisbouvier -- 18. High-throughput SAXS for the characterization of biomolecules in solution : a practical approach / Kevin N. Dyer, Michael Hammel, Robert P. Rambo, Susan E. Tsutakawa, Ivan Rodic, Scott Classen, John A. Tainer and Greg L. Hura -- 19. Measuring spatial restraints on native protein complexes using isotope-tagged chemical cross-linking and mass spectrometry / Franz Herzog -- 20. Modeling of proteins and their assemblies with the integrative modeling platform / Benjamin Webb, Keren Lasker, Javier Velázquez-Muriel, Dina Schneidman-Duhovny, Riccardo Pellarin, Massimiliano Bonomi, Charles Greenberg, Barak Raveh, Elina Tjioe, Daniel Russel and Andrej Sali -- 21. Quality and validation of structures from structural genomics / Marcin J. Domagalski, Heping Zheng, Matthew D. Zimmerman, Zhigniew Dauter, Alexander Wlodawer and Wladek Minor -- 22. Navigating the global protein-protein interaction landscape using iRefWeb / Andrei L. Turinsky, Sabry Razick, Brian Turner, Ian M. Donaldson and Shoshana J. Wodak -- 23. Mespeus-a database of metal interactions with proteins / Marjorie M. Harding and Kun-Yi Hsin -- 24. High-quality macromolecular graphics on mobile devices : a quick starter's guide / Chin-Pang Benny Yiu and Yu Wai Chen.
  • 2014 Springer Protocols
    edited by Wayne F. Anderson.
    Data Management in the Modern Structural Biology and Biomedical Research Environment -- Structural Genomics of Human Proteins -- Target Selection for Structural Genomics of Infectious Diseases -- Selecting Targets from Eukaryotic Parasites for Structural Genomics and Drug Discovery -- High Throughput Cloning for Biophysical Applications -- Expression and Solubility Testing in a High Throughput Environment -- Protein Production for Structural Genomics Using E. coli Expression -- Eukaryotic Expression Systems for Structural Studies -- Automated Cell-free Protein Production Methods for Structural Studies -- Parallel Protein Purification -- Oxidative Refolding from Inclusion Bodies -- High throughput Crystallization Screening -- Screening Proteins for NMR Suitability -- Salvage or Recovery of Failed Targets by in situ Proteolysis -- Salvage of Failed Protein Targets by Reductive Alkylation -- Salvage or Recovery of Failed Targets by Mutagenesis to Reduce Surface Entropy -- Data Collection for Crystallographic Structure Determination -- Structure, Determination, Refinement, and Validation -- Virtual High-Throughput Ligand Screening -- Ligand Screening using Fluorescence Thermal Shift Analysis (FTS) -- Ligand Screening using Enzymatic Assays -- Ligand Screening using NMR -- Screening Ligands by X-ray Crystallography -- Case Study Structural Genomics and Human Protein Kinases.
  • 2006 CRCnetBASE
    edited by Michael Sundströ̈m, Martin Norin, Aled Edwards.
  • 2006 CRCnetBASE
    edited by Kenneth H. Lundstrom.
    Bioinformatics in membrane protein analysis / Bengt Persson -- Prokaryotic membrane transport proteins / Joanne Clough ... [et al.] -- Membrane protein production strategies for structural genomics / Said Eshaghi and Par Nordlund -- Refolding of membrane proteins for large-scale production / Hans Kiefer, Thomas Ostermann, Monika Bahner -- Crystallization of membrane proteins / Alastair T. Gardiner, June Southall, and Richard J. Cogdell -- Signaling through membrane proteins / J. Robert Bostwick and Deborah S. Hartman -- Expression of membrane proteins in yeasts / Christoph Reinhart, Christoph Krettler -- Expression of functional membrane proteins in the baculovirus-insect cell system / Giel J.C.G.M. Bosman and Willem J. de Grip -- Expression of membrane proteins in mammalian cells / Kenneth Lundstrom -- Solubilization and purification of membrane proteins / Bernadette Byrne and Mika Jormakka -- Fluorescent labelling of membrane proteins in living cells / Ruud Hovius ... [et al.] -- Membrane protein NMR / Xiang-Qun (Sean) Xie -- Miniaturization of structural biology technologies--from expression to biophysical analyses / Enrique Abola, Peter Kuhn, and Raymond C. Stevens -- Electron microscopy and atomic force microscopy of reconstituted membrane proteins / Andreas Engel -- -- Structural genomics networks for membrane proteins / Kenneth Lundstrom -- Molecular modelling of membrane proteins / Slawomir Filipek and Anna Modzelewska -- Towards structural bases for GPCR ligand-binding / Sabrina A. Beretta ... [et al.].
  • edited by Kenneth H. Lundstrom.
    Bioinformatics in membrane protein analysis / Bengt Persson -- Prokaryotic membrane transport proteins / Joanne Clough ... [et al.] -- Membrane protein production strategies for structural genomics / Said Eshaghi and Pär Nordlund -- Refolding of membrane proteins for large-scale production / Hans Kiefer, Thomas Ostermann, Monika Bähner -- Crystallization of membrane proteins / Alastair T. Gardiner, June Southall, and Richard J. Cogdell -- Signaling through membrane proteins / J. Robert Bostwick and Deborah S. Hartman -- Expression of membrane proteins in yeasts / Christoph Reinhart, Christoph Krettler -- Expression of functional membrane proteins in the baculovirus-insect cell system / Giel J.C.G.M. Bosman and Willem J. de Grip -- Expression of membrane proteins in mammalian cells / Kenneth Lundstrom -- Solubilization and purification of membrane proteins / Bernadette Byrne and Mika Jormakka -- Fluorescent labelling of membrane proteins in living cells / Ruud Hovius ... [et al.] -- Membrane protein NMR / Xiang-Qun (Sean) Xie -- Miniaturization of structural biology technologies--from expression to biophysical analyses / Enrique Abola, Peter Kuhn, and Raymond C. Stevens -- Electron microscopy and atomic force microscopy of reconstituted membrane proteins / Andreas Engel -- -- Structural genomics networks for membrane proteins / Kenneth Lundstrom -- Molecular modelling of membrane proteins / Slawomir Filipek and Anna Modzelewska -- Towards structural bases for GPCR ligand-binding / Sabrina A. Beretta ... [et al.].
  • 2012 Springer
    Leonid Sazanov, editor.
    Complex I (NADH:ubiquinone oxidoreductase) is the first and largest enzyme of the respiratory chain in mitochondria and plays a central role in cellular energy production. Complex I dysfunction has been implicated in many human neurodegenerative diseases, including Parkinson's. Mutations in complex I subunits are among the most common human genetic disorders known. Until recently, in the absence of structural information, complex I was the least understood enzyme of the respiratory chain. The mechanism by which it couples electron transfer between NADH and quinone to the translocation of protons across the membrane was a complete enigma. Recent years have been marked by spectacular progress in the elucidation of complex I's structure, finally allowing the interpretation of a wealth of data accumulated in about 50 years since the discovery of the enzyme. Understanding of the mechanism of this large molecular machine, involving long-range conformational changes, is beginning to emerge. This book is the first devoted entirely to complex I. It contains chapters written by leaders in the field, covering a wide range of topics from the structure of the complex, properties of its many redox centers, subunit composition, mutagenesis studies, evolution of the enzyme and on to the current understanding of the coupling mechanism and the molecular basis for human pathologies. Features: - Concise and authoritative review of current state-of-the-art in research on respiratory complex I - The first book entirely devoted to complex I, a central enzyme in bioenergetics - Recent breakthroughs in structure elucidation finally allow understanding of the mechanism - Mutations leading to common and severe human disorders are discussed.
  • 2015 Springer Protocols
    edited by Raymond J. Owens, Oxford Protein Production Facility UK, Research Complex at Harwell, Oxfordshire, UK.
  • 2008 Springer Protocols
    edited by Bostjan Kobe, Mitchell Guss, Thomas Huber.
    Target selection for structural genomics : an overview / Russell L. Marsden and Christine A. Orengo -- A general target selection method for crystallographic proteomics / Gautier Robin ... [et al.] -- Target selection : triage in the structural genomics battlefield / James Raftery -- Data management in structural genomics : an overview / Sabrina Haquin ... [et al.] -- Data deposition and annotation at the worldwide protein data bank / Shuchismita Dutta ... [et al.] -- Prediction in protein disorder / Zsuzsanna Dosztányi and Peter Tompa -- Protein domain prediction / Helgi Ingolfsson and Golan Yona -- Protein structure modeling with MODELLER / Narayanan Eswar ... [et al.] -- High throughput cloning with restriction enzymes / Volker Sievert, Asgar Ergin, and Konrad Bussow -- Automated recombinant protein expression screening in Escherichia coli / Didier Busso ... [et al.] -- From no expression to high-level soluble expression in Escherichi coli by screening a library of the target proteins with randomized N-termini / Kyoung Hoon Kim ... [et al.] -- Application of high-throughput methodologies to the expression of recombinant proteins in E. coli / Yoav Peleg and Tamar Unger -- A high throughput platform for eukaryotic genes / Yunjia Chen ... [et al.] -- High throughput production of recombinant human proteins for crystallography / Opher Gileadi ... [et al.] -- Assembly of protein complexes by coexpression in prokaryotic and eukaryotic hosts : an overview / Anastassis Perrakis and Christophe Romier -- Cell-free protein synthesis for analysis by NMR spectroscopy / Margit A. Apponyi ... [et al.] -- A medium or high throughput protein refolding assay / Nathan P. Cowieson ... [et al.] -- Structural proteomics of membrane proteins : a survey of published techniques and design of a rational high throughput strategy / Melissa Swope Willis and Christopher M. Koth -- Methods for protein characterization by mass spectrometry, thermal shift (ThermoFluor) assay, and multiangle or static light scattering / Joanne E. Nettleship ... [et al.] -- High throughput methods for analyzing transition metals in proteins on a microgram scale / Anelia Atanassova, Martin Högbom, and Deborah B. Zamble -- High throughput screening of purified proteins for enzymatic activity / Michael Proudfoot ... [et al.] -- Strategies for improving crystallization success rates / Rebecca Page -- Protein crystallization in restricted geometry : advancing old ideas for modern times in structural proteomics / Joseph D. Ng, Raymond C. Stevens, and Peter Kuhn -- Fluorescence approaches to growing macromolecule crystals / Marc Pusey, Elizabeth Forsythe, and Aniruddha Achari -- Efficient macromoleular crystallization using microfluidics and randomized design of screening reagents / Andrew P. May and Brent W. Segelke -- Increasing protein crystallization screening success with heterogeneous nucleating agents / Anil S.Thakur ... [et al.] -- High throughput pH optimization of protein crystallization / Ran Meged, Orly Dym, and Joel L. Sussman -- Automated structure solution with the PHENIX suite / Peter H. Zwart ... [et al.] -- NMR screening for rapid protein characterization in structural proteomics / Justine M. Hill -- Microcoil NMR spectroscopy : a novel tool for biological high throughput NMR spectroscopy / Russell E. Hopson and Wolfgang Peti -- Protein structure determination using a combination of cross-linking, mass spectrometry, and molecular modeling / Dmitri Mouradov ... [et al.] -- Structural genomics of minimal organisms : pipeline and results / Sung-Hou Kim ... [et al.] -- Structural genomics of pathogenic protozoa : an overview / Erkang Fan ... [et al.] -- High throughput crystallography at SGC Toronto : an overview / Alexey Bochkarev and Wolfram Tempel -- The structural biology and genomics platform in Strasbourg : an overview / Didier Busso, Jean-Claude Thierry, and Dino Moras -- Bacterial structural genomics initiative : overview of methods and technologies applied to the process of structure determination / Miroslaw Cygler ... [et al.] -- High-throughput protein production and crystallization at NYSGXRC / Michael J. Sauder ... [et al.] -- Overview of the pipeline for structural and functional characterization of macrophage proteins at the University of Queensland / Weining Meng ... [et al.] -- Structural genomics of the bacterial mobile metagenome : an overview / Andrew Robinson ... [et al.].
  • 2008
    Gary A. Thibodeau, Kevin T. Patton.
    Status: Not Checked OutLane Catalog Record
  • 1995 ScienceDirect
    editors, R. Lipowsky, E. Sackmann.
    v. 1A From cells to vesicles -- v. 1B Generic and specific interactions. Biological membranes architecture and function / E. Sackmann -- The evolution of membranes / M. Bloom and O.G. Mourttsen -- Polymorphism of lipid-water systems / J.M. Seddon and R.H. Templer -- Phospholipid monolayers / H. Möhwald -- Physical basis of self-organization and function of membranes : physics of vesicles / E. Sackmann -- Lateral diffusion in membranes / P.F.F. Almeida and W.L.C. Vaz -- Molecular theory of chain packing, elasticity and lipid-protein interaction in lipid bilayers / A. Ben-Shaul -- Morphology of vesicles / U. Seifert and R. Lepowsky -- Material transport across permeability barriers by means of lipid vesicles / G. Cevc -- Applications of liposomes / D.D. Lasic -- Generic interactions of flexible membranes / R. Lipowsky -- Electrostatic properties of membranes : the Poisson-Boltzmann theory / D. Andelman -- Interaction in membrane assemblies / V.A. Parsegian and R.P. Rand -- Tension-induced mutual adhesion and a conjectured superstructure of lipid membranes / W. Helfrich -- Physical actions in biological adhesion / E. Evans -- Adhesion of cells / P. Bongrand -- Cell membranes and the cytoskeleton / P. Janmey -- Electroporation and electrofusion of membranes / D.S. Dimitrov -- Cation-induced vesicle fusion modulated by polymers and proteins / K. Arnold.
  • 2010 CRCnetBASE
    Peter Tompa.
    Principles of protein structure and function -- A brief history of protein disorder -- Indirect techniques for recognizing and characterizing protein disorder -- Hydrodynamic techniques -- Spectroscopic techniques for characterizing disorder -- Nuclear magnetic resonance -- Proteomic approaches for the identification of IDPs -- IDPs under conditions approaching in vivo -- Prediction of disorder -- Structure of IDPs -- Biological processes enriched in disorder -- Molecular functions of disordered proteins -- Evolution and prevalence of disorder -- Extension of the structure-function paradigm -- Structural disorder and disease.
  • 2006 Springer
    edited by Robert R. Wise and J. Kenneth Hoober.
  • 2010 Springer
    Vladimir Berezin, editor.
    Part I. Structure and ligands of NCAM. -- Structural biology of NCAM / Vladislav Soroka, Christina Kasper, Flemming M. Poulsen. -- Extracellular protein interactions mediated by the neural cell adhesion molecule, NCAM: heterophilic interactions between NCAM and cell adhesion molecules, extracellular matrix proteins, and viruses / Janne Nielsen, Nikolaj Kulahin, Peter S. Walmod. -- Intracellular (intracelluar) ligands of NCAM / Bettina Buttner, Rudiger horstkorte. -- Role of ATP in the regulation of NCAM function / Martin V. Hubschmann, Galina Skladchikova. -- Part II. NCAM and plysialic acid. -- Polysialylation of NCAM / Herbert Hildebrandt, Martina Muhlenhoff, Rita Gerardy-Schahn. -- Structural basis for the polysialylation of the neural cell adhesion molecule / Karen J. Colley. -- Role of PSA-NCAM in adult neurogenesis / Eduardo Gascon, Laszlo Vutskits, Jozsel Zoltan Kiss. -- Use of PSA-NCAM in repair of the central nervous system / Abderrahman El Maarouf, Urs Rutishauser. -- Part III. NCAM-mediated signal transduction. -- Signaling pathways involved in NCAM-induced neurite outgrowth / Dorte Kornerup Ditlevsen, Kateryna Kolkova. -- Role of the growth-associated protein GAP-43 in NCAM mediated neurite outgrowth / Irina Korshunova, Mark Mosevitski. -- Neural cell adhesion molecule NCAM and lipid rafts / Gro Klitgaard Povlsen, Dorte Kornerup Ditlevsen. -- Neural cell adhesion molecule and epidermal growth factor receptor: signaling crosstalk / Gro Klitgaard Polvsen. -- Part IV. NCAM metabolism. -- Biosynthesis of NCAM / Kateryna Kolkova. -- Soluble NCAM / Thomas Secher. -- Part V. NCAM, synapses, emotions, and memory. -- Role of NCAM in spine dynamics and synaptogenesis / D. Muller, P. Mendez, M. DeRoo, P. Klauser, S. Steen, and L. Poglia. -- NCAM in long-term potentiation and learning / Barbara P. Hartz, Lars Christian B. Roon. -- Role of NCAM in emotion and learning / Lisa Conboy, Reto Bisaz, Kamila Markram, Carment Sandi. -- Part VI. NCAM in disease. -- NCAM in neuropsychiatric and neurodegenerative disorders / Leann H. Brennaman, Patricia F. Maness. -- Neural cell adhesion molecule in cancer: expression and mechanisms / Silvia Zecchini, Ugo Caallaro. -- Part VII. Pharmacology of NCAM: NCAM mimetics. -- NCAM mimetic peptides: an update / Vladimir Berezin, Elisabeth Bock. -- Synthetic NCAM-derived ligands of the fibroblast growth factor receptor / Stine maria Hansen, Shizhong Li, Elisabeth Bock, Vladimir Berezin. -- Dendritic spine and synapse morphological alterations induced by neural cell adhesion molecule mimetic / Michael Stewart, Victor Popov, Nikolai Medvedev, Paul Giabbon, Nicola Corbett, Igor Kraev, Heather Davies. -- Part VIII. Orthologs and paralogs of NCAM. -- Fasciclin II: the NCAM ortholog in Drosophila melanogaster / Lars V. Kristiansen, Michael Hortsch. -- Neural cell adhesion molecule NCAM2/OCAM/RNCAM, a close relative to NCAM / Nikolaj Kulahin, Peter S. Walmod. -- Part IX. Conclusion. -- Honoring Dr. Elisabeth Bock / Vladimir Berezin.
    Also available: Print – 2010
  • 2013 Springer
    Mauricio G. Mateu, editor.
    This book contemplates the structure, dynamics and physics of virus particles: From the moment they come into existence by self-assembly from viral components produced in the infected cell, through their extracellular stage, until they recognise and infect a new host cell and cease to exist by losing their physical integrity to start a new infectious cycle. (Bio)physical techniques used to study the structure of virus particles and components, and some applications of structure-based studies of viruses are also contemplated. This book is aimed first at M.Sc. students, Ph.D. students and postdo
  • 2013
    James Eliot Fitzgerald.
    How do the structure and dynamics of neural circuits conspire with circuit inputs to solve specific computational problems in the brain? In this thesis we use theory, often in coordination with experiment, to study several problems with relevance to this question. First, we use estimation theory to develop a measure of spatial resolution for stochastic localization microscopy that jointly depends on the density of fluorescent emitters, the precision of emitter localization, and prior information regarding the labeled object. This resolution measure clarifies the conditions under which optical methods suffice to measure neural circuit structure. Second, we use signal detection and estimation theory to quantify the physical limits set by photon shot noise for the optical detection and timing of neural spikes. This framework provides a quantitative benchmark for optical methods that measure the dynamics of neural circuits. Third, we combine time-lapse two-photon microendoscopy and mathematical modeling to track and quantify the dynamics of dendritic spines in the CA1 hippocampal area of living mice. Our results suggest new relationships between structure, dynamics, and function in the hippocampal circuit. Fourth, we treat visual motion estimation as a problem of Bayesian inference to determine how the optimal algorithm for motion estimation depends on the statistics of visual inputs. Our theory reveals that dark-light contrast asymmetries facilitate motion estimation with triple correlations. Finally, we show that fly and human visual systems jointly encode the direction and contrast polarity of moving edges using triple correlations that enhance motion estimation of natural stimuli. This striking convergence argues that the statistics of natural inputs have driven a common computational strategy for motion estimation across 500 million years of evolution. Collectively, these projects demonstrate several distinct and complementary ways that the integration of theory and experiment can accelerate progress in neuroscience.
  • 2005 CRCnetBASE
    edited by Philip L. Yeagle.
    Chapter 1. Lipid structure -- Chapter 2. The mesomorphic phase behavior of lipid bilayers -- Chapter 3. Lipid bilayer interdigitation -- Chapter 4. The dynamics of membrane lipids -- Chapter 5. Nonlamellar lipid phases -- Chapter 6. The forces between interacting bilayer membranes and the hydration of phospholipid assemblies -- Chapter 7. The roles of cholesterol in the biology of cells -- Chapter 8. Lipid membrane fusion -- Chapter 9. Membrane rafts -- Chapter 10. Passive and facilitated transport -- Chapter 11. Membrane protein dynamics: rotational dynamics -- Chapter 12. Translational diffusion of membrane proteins -- Chapter 13. Inorganic anion transporter AE1 -- Chapter 14. The structures of G-protein coupled receptors -- Chapter 15. Role of membrane lipids in modulating the activity of membrane-bound enzymes -- Chapter 16. Viral fusion mechanisms.
  • 2006 Springer
    A. Brehmer.
  • 1975-
    by Richard Bandler and John Grinder.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    edited by Harren Jhoti, Andrew R. Leach.
  • 2012 Springer Protocols
    edited by Leslie W. Tari.
    The utility of structural biology in drug discovery / Leslie W. Tari -- Genetic construct design and recombinant protein expression for structural biology / Suzanne C. Edavettal, Michael J. Hunter, and Ronald V. Swanson -- Purification of proteins for crystallographic applications / Daniel C. Bensen -- Protein crystallization for structure-based drug design / Isaac D. Hoffman -- X-ray sources and high-throughput data collection methods / Gyorgy Snell -- The use of molecular graphics in structure-based drug design / Paul Emsley and Judit É. Debreczeni -- Crystallographic fragment screening / John Badger -- The role of enzymology in a structure-based drug discovery program : bacterial DNA gyrase / Mark L. Cunningham -- Leveraging structural information for the discovery of new drugs : computational methods / Toan B. Nguyen, Sergio E. Wong, and Felice C. Lightstone -- Chemical informatics : using molecular shape descriptors in structure-based drug design / Andy Jennings -- Accounting for solvent in structure-based drug design / Leslie W. Tari -- Structure-based drug design on membrane protein targets : human integral membrane protein 5-lipoxygenase-activating protein / Andrew D. Ferguson -- Application of SBDD to the discovery of new antibacterial drugs / John Finn -- Leveraging SBDD in protein therapeutic development : antibody engineering / Gary L. Gilliland [and others] -- A medicinal chemistry perspective on structure-based drug design and development / Shawn P. Maddaford.
  • 2010 Springer
    Wanderley de Souza, editor.
    The Mastigont System in Trichomonads / Marlene Benchimol -- Subpellicular Microtubules in Apicomplexa and Trypanosomatids / Wanderley de Souza and Marcia Attias -- Flagellum Structure and Function in Trypanosomes / Johanna Buisson and Philippe Bastin -- The Flagellar Pocket of Trypanosomatids: A Critical Feature for Cell Morphogenesis and Pathogenicity / Paul G. McKean and Keith Gull -- Reservosomes of Trypanosoma cruzi / Narcisa Leal Cunha-e-Silva, Celso Sant'Anna, Miria G. Pereira and Wanderley de Souza -- Megasomes in Leishmania / Diane McMahon-Pratt, Tania Ueda-Nakamura and Yara M. Traub-Csekö -- Organelles and Trafficking in Entamoeba histolytica / Sherri S. Smith and Nancy Guillen -- Secretory Organelles in Apicomplexa / Jean François Dubremetz -- Secretory Events During Giardia Encystation / Fernando D. Rivero, Dana Müller and Hugo D. Lujan -- The Remarkable Mitochondrion of Trypanosomes and Related Flagellates / Julius Lukeš, Hassan Hashimi, Zdeněk Verner and Zdeňka Čičová -- The Apicoplast: An Ancient Algal Endosymbiont of Apicomplexa / Swati Agrawal, Sethu Nair, Lilach Sheiner and Boris Striepen -- The Glycosome of Trypanosomatids / Fred R. Opperdoes -- Calcium Homeostasis and Acidocalcisomes in Trypanosoma cruzi / Paul Ulrich, Roxana Cintrón and Roberto Docampo.
  • 2015 ScienceDirect
    edited by Sarah A. Woodson and Frédéric H.T. Allain.
    Native purification and analysis of long RNAs -- Characterizing RNA excited states using NMR relaxation -- Quantifying nucleic acid ensembles with x-ray scattering interferometry -- 2-aminopurine fluroescence as a probe of local RNA structure and dynamics and global folding -- Mod-seq: a high-throughput method for probing RNA secondary structure -- Reproducible analysis of sequencing-based RNA structure probing data with user-friendly tools -- Computational methods for RNA structure validation and improvement -- Structures of large RNAs and RNA-protein complexes: toward structure determination of riboswitches -- One, two, three, four! How multiple RRMs read the genome sequence -- Combining NMR and EPR to determine structures of large RNAs and protein-RNA complexes in solution -- Structural analysis of protein-RNA complexes in solution using NMR paramagnetic relaxation enhancements -- Resolving individual components in protein-RNA complexes using small-angle x-ray scattering experiments -- Small-anlge neurtron scattering for structural biology of protein-RNA complexes -- Strudying RNA-protein interactions of Pre-mRNA complexes by mass spectrometry -- RNA bind-n-Seq: measuring the binding affinity landscape of RNA-binding proteins -- Using molecular simulation to model high-resolution Cryo-EM reconstructions -- In vitro reconstitution and crystallization of Cas9 endonuclease bound to a guide RNA and a DNA target -- Single-molecule pull-down FRET to dissect the mechanisms of biomolecular machines -- Single-molecule imaging of RNA splicing in live cells.
  • 2006
    Paul Insel, R. Elaine Turner, Don Ross.
    Status: Not Checked OutLane Catalog Record
  • 1935.
    von Erling Rustung.
    I. Untersuchung über das Rachitisvorkommen in einem norwegischen Binnental.
  • v. 184, 212-213, 216, 2005, 2007. Springer
    Also available: Print – v. 83, 2002.
  • 1920
  • 1930-
    by N. Hamilton Fairley ... Lieut.-Colonel F.P. Mackie ... and F. Jasudasan ...
  • 2013
    Shanshan Tuo.
    This dissertation describes investigations of the machinery of cell polarization in the budding yeast Saccharomyces cerevisiae. Cell polarization is an essential feature of most, if not all, cell types. It occurs in two steps: (1) the selection of an axis and (2) the asymmetric organization of organelles, the cytoskeleton, and plasma-membrane components along this axis. The selection of an axis in S. cerevisiae is manifested as bud-site selection. S. cerevisiae cells select bud sites in either of two patterns, known as the axial and bipolar, depending on the mating type of the cells. Normal haploid cells use the axial pattern, whereas normal diploid cells use the bipolar pattern. Beginning with a re-analysis of the phenotypes of 38 mutants reported in a genome-wide screen to be defective in bipolar-bud-site selection, I focused on two groups of mutants with distinct phenotypes and tried to elucidate the molecular mechanisms underlying these phenotypes. The first group contains two mutants, bud13[Delta] and ist3[Delta]; the second group contains 14 endocytosis-related mutants. Each group has led to a separate story of how the corresponding proteins are involved in bipolar-bud-site selection. First, I found (Chapter 2) that Bud13 and Ist3 are responsible specifically for the efficient pre-mRNA splicing of MATa1, which encodes a cell-type-specific regulator for the expression of haploid-specific genes. One of these genes, AXL1, encodes a protein whose ectopic expression in diploid cells causes override of the bipolar-budding mechanism by the axial budding mechanism. Second, I found (Chapter 3) that endocytosis-related proteins are involved in maintaining the localization, and thus the function, of bipolar marker proteins including Bud8 and Bud9.
  • v. 1-2, 1974.
    Edited by S. B. Sells. Foreword by Lois R. Chatham. Contributions by Robert G. Demaree, and others.
    Status: Not Checked OutLane Catalog Record
    v. 1. Evaluation of treatments.--v. 2. Research on patients, treatments, and outcomes.--v. 3. Further studies of drug users, treatment typologies, and assessment of outcomes during treatment in DARP.--v. 4. Evaluation of treatment outcomes for 1971-1972 DARP admission cohort.--v. 5. Evaluation of treatment outcomes for 1972-1973 DARP admission cohort.
  • 2013 Springer
    Domenico Praticò, Patrizia Mecocci, editors.
    This volume systematically reviews the basic science and clinical knowledge of the role of free radicals and antioxidants, collectively known as oxidative stress, in the pathology of Alzheimer's disease. It describes the most current diagnostic tools, laboratory methods and technology, and suggests ways of prevention and treatment to emphasize the concept of the bench-to-bedside approach. Studies on Alzheimer's Disease provides thorough coverage of emerging technology and medical applications including discussions of biomarkers and antioxidants as therapeutic agents, and several more relevant aspects. In addition, this book promotes the concept of using biomarkers representative of oxidative stress reactions and free-radical damage, as well as describing the effects of antioxidants in treating disease in clinical trials. This content is invaluable to both researchers studying the development of and clinicians treating patients with a diagnosis of Alzheimer's Disease.
  • 2013 Springer
    Maria Jose Alcaraz, Oreste Gualillo, Olga Sanchez-Pernaute, editors.
    Joint diseases are a major public health concern. Reactive oxygen species are mediators in pathways associated with joint tissue injury. Oxidative Stress in Applied Basic Research and Clinical Practice: Studies on Arthritis and Joint Disorders provides background to understanding the role of reactive oxygen species in joint diseases, as well as therapeutic strategies for their regulation. International experts discuss recent advances on experimental and clinical data focused on free radical-mediated mechanisms of disease. The book also addresses the protective role of antioxidants against the insult of reactive oxygen species in rheumatic diseases.
  • 2010 Springer
    Heinrich Sauer, Ajay M. Shah, Francisco R.M. Laurindo, editors.
    The Evolving Concept of Oxidative Stress / Denise de Castro Fernandes, Diego Bonatto and Francisco R.M. Laurindo -- Mechanisms of Redox Signaling in Cardiovascular Disease / Rebecca L. Charles, Joseph R. Burgoyne and Philip Eaton -- Reactive Oxygen and Nitrogen Species in Cardiovascular Differentiation of Stem Cells / Heinrich Sauer and Maria Wartenberg -- Reactive Oxygen Species (ROS) and the Sensory Neurovascular Component / Rabea Graepel, Jennifer Victoria Bodkin and Susan Diana Brain -- Mitochondrial Reactive Oxygen Species in Myocardial Pre- and Postconditioning / Ariel R. Cardoso, Bruno B. Queliconi and Alicia J. Kowaltowski -- Coenzyme Q9/Q10 and the Healthy Heart / Samarjit Das, Somak Das and Dipak K. Das -- Oxidative and Proteolytic Stress in Homocysteine-Associated Cardiovascular Diseases / Karni S. Moshal, Munish Kumar, Neetu Tyagi, Paras Kumar Mishra and Saumi Kundu, et al. -- Functional Studies of NADPH Oxidases in Human Vasculature / Tomasz J. Guzik -- Relationship of the CYBA Gene Polymorphisms with Oxidative Stress and Cardiovascular Risk / Guillermo Zalba and Javier Díez -- Redox-Related Genetic Markers of Cardiovascular Diseases / Christian Delles and Anna F. Dominiczak -- NADPH Oxidases and Blood-Brain Barrier Dysfunction in Stroke / Timo Kahles, Sabine Heumüller and Ralf P. Brandes -- Smoking-Induced Oxidative Stress in the Pathogenesis of Cardiovascular Diseases / David Bernhard -- Oxidative Stress in Vascular Aging / Anna Csiszar and Zoltan Ungvari -- Oxidative Stress and Cardiovascular Disease in Diabetes Mellitus / Divya Gupta, Kathy K. Griendling and W. Robert Taylor -- Reactive Oxygen Species, Oxidative Stress, and Hypertension / Rhian M. Touyz, Andreia Chignalia and Mona Sedeek -- Peripartum Cardiomyopathy: Role of STAT-3 and Reactive Oxygen Species / Denise Hilfiker-Kleiner, Arash Haghikia and Andres Hilfiker -- Oxidative Stress and Inflammation after Coronary Angiography / Raymond Farah -- Oxidative Stress in Cardiac Transplantation / Galen M. Pieper and Ashwani K. Khanna -- Oxidative Stress and Atrial Fibrillation / Ali A. Sovari and Samuel C. Dudley -- Oxidative Stress and the Antioxidative Capacity in Myocardial Infarction / Yao Sun -- Oxidative Stress and Redox Signalling in Cardiac Remodelling / Min Zhang, Alex Sirker and Ajay M. Shah -- Oxidative Stress and Cardiovascular Fibrosis / Subramaniam Pennathur, Louise Hecker and Victor J. Thannickal -- Oxidative Risk Factors for Cardiovascular Disease in Women / Manuela Gago-Dominguez, Xuejuan Jiang and Jose Esteban Castelao -- Protective Effects of Food on Cardiovascular Diseases / Alfonso Giovane and Claudio Napoli -- Novel Synthetic Antioxidants and Nitrated Lipids: From Physiology to Therapeutic Implications / Gloria V. López and Homero Rubbo -- Thioredoxin in the Cardiovascular System-Towards a Thioredoxin-Based Antioxidative Therapy / Cameron World and Bradford C. Berk -- The Protective Effect of Melatonin on the Heart / Amanda Lochner -- Exercise-Induced Cardioprotection: Overview with an Emphasis on the Role of Antioxidants / Karyn L. Hamilton and John C. Quindry -- Antioxidative Properties of Statins in the Heart / Oliver Adam and Ulrich Laufs.
  • 2012 Springer
    Ashok Agarwal, R. John Aitken, Juan G. Alvarez, editors.
  • 2011 Springer
    Toshio Miyata, Kai-Uwe Eckardt, Masaomi Nangaku, editors.
  • 2012 Springer
    Robert D. Stratton, William W. Hauswirth, Thomas W. Gardner, editors.
    Studies on Retinal and Choroidal Disorders examines the role that oxidative and nitrosative stress plays in the complex physiology and pathophysiology of the retina and choroid. Both the basic science researcher and the clinical practitioner can use this book as a guide to the current understanding of retinal and choroidal cellular mechanisms involved in aging and disease. Beginning with a review of oxidative stress and inflammation in the pathoetiology of AMD and a review of the complement system in the retina, the book then takes a detailed look at oxidative stress in lipid metabolism and oxidized lipoproteins in the retina. It examines the anti-apoptotic activity of -crystallins in the presence of glutathione, oxidative stress in the mitochondria and endoplasmic reticulum, the role of iron in retinal disease, the mechanisms of pathological VEGF expression, NAPDH oxidase mechanisms, and Hepatocyte Growth Factor in oxidative stress in the retina. A detailed look at the Ccl2-/-/Cx3cr1-/- mouse model of AMD follows. Then a detailed examination of the systemic changes in AMD is followed by a discussion of cerium oxide nanoparticle reduction of oxidative stress. Two chapters discuss progenitor cells in the cause and treatment of retinal diseases including AMD and diabetic retinopathy. Natural compounds in the prevention and treatment of retinal diseases are exhaustively presented, followed by a chapter on serotonin 5-HT1A receptor agonists in oxidative stress of the retina. The current anti-VEGF treatment strategies of neovascular AMD are then given. The volume continues with a detailed look at nitric oxide and inducible nitric oxide synthase in retinal vascular disease, an explanation of an in vivo technique of studying the effect of lipid hydroperoxides on circulating leucocytes in the retina, an excellent review of oxidative stress in retinopathy of prematurity, and a look at VEGF induced oxidative stress in the retinal ganglion cell. The book ends with a detail examination of the role of carotenoids in retinal health and disease. These 31 chapters summarize what is known about oxidative stress in retinal and choroidal disorders. All those involved with degenerative diseases of the eye will find Studies on Retinal and Choroidal Disorders to be illuminating and comprehensive.
  • 2013 Springer
    Ashok Agarwal, Nabil Aziz, Botros Rizk, editors.
  • 2006
    Mitchell H. Katz.
    Status: Not Checked OutLane Catalog Record
  • 2015 PsychiatryOnline
    edited by Philip R. Muskin.
  • 2013 Ovid
    Richard K. Riegelman.
    Evidence-based information plays a critical role in clinical practice decisions. Secondary sources are often unreliable; it.s up to the student, then, to critically assess peer-reviewed research literature. Using a highly structured yet accessible method, this text teaches students to critically analyze research from primary sources. Step-by-step approach. learn to recognize a meaningful study, clues to potential study flaws, and ways to apply solid evidence in clinical practice. Simple 6-point framework. learn to evaluate studies in terms of the authors trademark mnemonic device, M.A.A.R.I.E. (Methods, Assignment, Assessment, Results, Interpretation and Extrapolation). Unique Learning Aids - question checklists, real-world scenarious, flaw-catching exercises and more help to make complex concepts easy to grasp.
  • 2008 Springer
    Nicholas T. Longford.
  • 2011
    Megan Amanda Hartman.
    Molecular motors utilize energy from ATP hydrolysis to perform mechanical work, and examples include the myosins, a superfamily of proteins that utilizes actin filaments as a track for processive movement. There are many classes of myosins, and they share common elements necessary to regulate actin binding and force generation based on the identity of the nucleotide bound. Their diversity is most evident in their C-terminal tails; in the case of the unconventional myosins that do not form bipolar thick filaments, these regions mediate their associations with specific binding partners. Interactions between myosins and cognate adaptors allow for their recruitment onto cargoes, and it is these cargoes that define the functions of myosins in a cellular environment. Numerous studies have suggested developmental and cellular roles for myosins, but in general, few binding proteins have been discovered for most family members. In the case of mammalian myosin VI, yeast two-hybrid screening has revealed several adaptors that link this motor to vesicles, endosomes, and the Golgi, where it participates in a number of trafficking events. In contrast, very little is known about the proteins that bind to Drosophila myosin VI, despite the necessity of this protein for many essential processes during fly development. To better understand the specific pathways to which myosin VI contributes in flies, we set out to identify its cargoes. We used a combination of affinity chromatography and mass spectrometry in a proteomics-based screen to discover candidates, given the many advantages of this method over yeast two-hybrid and other approaches. Upon obtaining data indicating that over 1000 proteins could potentially associate with myosin VI, we were next charged with determining which interactions were specific and direct, and we chose to screen through select candidates with an in vitro assay. We identified a number of novel cargoes for myosin VI, including those associated with the Golgi, protein trafficking, microtubules, and others of unknown function. Next, we attempted to perform another screen to identify binding partners that might mediate the function of myosin VI in dorsal closure during embryogenesis. Because this motor is very concentrated at the leading edge of cells during this process, we developed an antibody to myosin VI for immunolocalization studies. We then examined embryos mutant for or depleted of myosin VI cargoes and assessed any effect on myosin VI localization. Although some showed slight differences in the staining pattern, we chose a different assay to test for a shared function between myosin VI and one of its novel cargoes. After commencing this project, we became aware of data indicating that myosin VI and Cornetto, one of the novel binding proteins we discovered, participate in Hedgehog secretion. Without further information about the assay used or the results obtained, we used cell culture to validate the original screen data and found that both proteins are indeed required for the timely secretion of exogenously expressed Hedgehog (Hh) from S2R+ cells. We then began examining embryos for defects associated with reduced Hedgehog secretion and found that a small percentage of flies expressing Cornetto RNAi or a dominant negative myosin VI truncation in Hh-producing cells indeed have the types of segmentation problems found in mild hedgehog mutants. Thus, we found a shared function for myosin VI and one of its binding proteins, which not only validates our screen data but also provides important information not previously available about their roles in development. In a second project, I turned my attention to another function for myosin VI to analyze its binding protein CG3529, which is orthologous to Tom1 family proteins involved in membrane trafficking. Based on information available about orthologs, I reasoned that CG3529 might mediate the involvement of myosin VI in asymmetric Notch signaling during pupal development, a role identified for this motor in another large-scale RNAi screen. Despite finding no evidence linking CG3529 to asymmetric trafficking of Notch in the dorsal epidermis as I had hypothesized, it was apparent that CG3529 depletion does affect mechanosensory bristle length, which had been previously noted for myosin VI as well. I then performed experiments to help determine by what pathway these proteins contributed to this process, but the data I collected did not indicate a shared function or binding interactions between CG3529 and the proteins to which its orthologs had been linked. Although it is still not clear what the function of this myosin VI adaptor is, I suspect that it is involved in protein trafficking at or near the endoplasmic reticulum, given that CG3529 appears to localize to this compartment. Beyond the proteins whose functions we were able to address, we obtained many other candidates that could potentially link myosin VI to a variety of cellular compartments and signaling pathways. The data presented here should be useful in future work to analyze the roles of myosin VI in specific systems upon utilization of information available about its novel binding proteins.
  • 2012
    Xiaohu Ouyang.
    Embryonic development and tissue regeneration are regulated by complex genetic programs that are dynamically executed in a stereotypic manner, and deciphering these molecular mechanisms requires the ability to control gene function with spatial and temporal precision. Synthetic chemistry has been increasingly used to create reagents that can enable such genetic manipulations. In this thesis I describe the development and application of caged morpholino (cMO) oligonucleotides and small molecules to study zebrafish embryonic development and larvae tail regeneration. In Chapter 1, we survey how chemical tools and engineered proteins have been used to perturb developmental processes at the DNA, RNA, protein, and cellular levels. We discuss the design principles, experimental capabilities, and limitations of each method, as well as future challenges for the chemical and developmental biology communities. In Chapter 2, we describe optimized methods for the design and synthesis of hairpin cMO oligonucleotides incorporating a dimethoxynitrobenzyl (DMNB)-based bifunctional linker that permits cMO assembly in only three steps from commercially available reagents. Using this simplified procedure, we have systematically prepared cMOs with differing structural configurations and investigated how the in vitro thermodynamic properties of these reagents correlate with their in vivo activities. Through these studies, we have established general principles for cMO design and successfully applied them to several developmental genes. Our optimized synthetic and design methodologies have also enabled us to prepare a next-generation cMO that contains a bromohydroxyquinoline (BHQ)-based linker for two-photon uncaging. Collectively, these advances establish the generality of cMO technologies and will facilitate the application of these chemical probes in vivo for functional genomic studies. In Chapter 3, I first describe our genome-wide microarray analysis and whole-mount in situ hybridization studies that led us to the identification of 18 genes, including hyaluronan synthase 3 (has3), that were expressed during zebrafish larvae tail regeneration. I also report the functional studies of hyaluronan (HA) synthesis using small molecule inhibitor 4-methylumbelliferone (4-MU), in which we showed that 4-MU inhibited tail regeneration by preventing injury-induced cell proliferation. In addition, 4-MU also reduced the expressions of dlx5a and junbb, markers of the wound epithelium and blastema-like mesenchymal cells. We also illustrated that simultaneous dosing of Gsk3[beta] inhibitor BIO and 4-MU could rescue the 4-MU-induced regeneration defects. Our results indicated that the crosstalk between hyaluronan synthesis and Gsk3[beta] signaling played an important role in regulating tail regeneration.
  • 2015 Springer
    Gabriel J. E. Rinkel, Paut Greebe.
    "This pocket-sized book is a quick-reference practical guide for physicians who deal with patients with subarachnoid hemorrhage or intracranial aneurysms outside the hospital. It describes briefly the epidemiology of subarachnoid hemorrhage, the early recognition and clinical course, and in more depth the aftercare, residual symptoms and deficits. The prognosis and management in the long term are discussed in detail. It also provides information on the counselling and treatment of patients with unruptured intracranial aneurysms. Subarachnoid Hemorrhage in Clinical Practice is aimed at general practitioners and family physicians and will also be informative for other specialists such as rehabilitation physicians, nursing home physicians, and physicians working for health insurance companies. It may also be of interest to patients, relatives, and paramedics."--Back cover.
  • 2006
    Anne Nicole Tecklenburg Strehlow.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    edited by Eric Bertrand and Michel Faupel.
  • 2009 Springer
    Leonard F. Koziol, Deborah Ely Budding.
    Defines the functional neuroanatomy of cortical-subcortical circuitries and establishes that since structure is related to function, what the basal ganglia and cerebellum do for movement they also do for cognition and emotion. This book also examines neuropsychological assessment.
  • v. 1-9, 1980.
    Status: Not Checked OutLane Catalog Record
    There are 9 vols. in the Subject section; 5 vols. in the Biographical section and 4 vols. in the Topographical section. This series reproduces the card subject catalog of the library and includes a cumulation of Current Work in the History of Medicine (No. 6451.1). Material is included until 1977.
  • 2013 NAP
    Arthur A. Stone and Christopher Mackie, editors ; Panel on Measuring Subjective Well-Being in a Policy-Relevant Framework, Committee on National Statistics, Division on Behavioral and Social Sciences and Education, National Research Council of the National Academies.
    Subjective well-being refers to how people experience and evaluate their lives and specific domains and activities in their lives. This information has already proven valuable to researchers, who have produced insights about the emotional states and experiences of people belonging to different groups, engaged in different activities, at different points in the life course, and involved in different family and community structures. Research has also revealed relationships between people's self-reported, subjectively assessed states and their behavior and decisions. Research on subjective well-being has been ongoing for decades, providing new information about the human condition. During the past decade, interest in the topic among policy makers, national statistical offices, academic researchers, the media, and the public has increased markedly because of its potential for shedding light on the economic, social, and health conditions of populations and for informing policy decisions across these domains. Subjective Well-Being: Measuring Happiness, Suffering, and Other Dimensions of Experience explores the use of this measure in population surveys. This report reviews the current state of research and evaluates methods for the measurement. In this report, a range of potential experienced well-being data applications are cited, from cost-benefit studies of health care delivery to commuting and transportation planning, environmental valuation, and outdoor recreation resource monitoring, and even to assessment of end-of-life treatment options. Subjective Well-Being finds that, whether used to assess the consequence of people's situations and policies that might affect them or to explore determinants of outcomes, contextual and covariate data are needed alongside the subjective well-being measures. This report offers guidance about adopting subjective well-being measures in official government surveys to inform social and economic policies and considers whether research has advanced to a point which warrants the federal government collecting data that allow aspects of the population's subjective well-being to be tracked and associated with changing conditions.
  • 2005 Ovid
    editors, Joyce H. Lowinson ... [et al.].
    I. Foundations -- Historical perspectives / David F. Musto -- Epidemiology / Charles Winick and R.L. Norman -- U.S. federal drug policy / Mathea Falco -- II. Determinants of substance abuse and dependence -- Genetic factors in the risk for substance use disorders / Show W. Lin and Robert M. Anthenelli -- Brain-reward mechanisms / Eliot L. Gardner -- Psychodynamics / Edward J. Khantzian, Lance Dodes, Nancy M. Brehm -- Sociocultural issues / Bruce D. Johnson and Andrew Golub -- III. Substances of abuse -- Alcohol: neurobiology / Stephen L. Boehm II, C. Fernando Valenzuela, R. Adron Harris -- Alcohol: clinical aspects / Bankole A. Johnson and Nassima Ait-Daoud -- Opiates: neurobiology / Eric J. Simon -- Opiates: clinical aspects / Clifford M. Knapp, Domenic A. Ciraulo, and Jerome Jaffe -- Cocaine and crack: neurobiology / Martin Repetto and Mark S. Gold -- Cocaine and crack: clinical aspects / Mark S. Gold and William S. Jacobs -- The Neurobiology of marijuana / Sandra P. Welch -- Marihuana: clinical aspects / Lester Grinspoon, James B. Bakalar, and Ethan Russo -- Amphetamines and other stimulants / George R. King and Everett H. Ellinwood, Jr. -- Sedative-hypnotics / Donald R. Wesson, David E. Smith, Walter Ling, and Richard B. Seymour -- Hallucinogens / Robert N. Pechnick and J. Thomas Ungerleider -- Phencyclidine (PCP) / Stephen R. Zukin, Zili Sloboda, and Daniel C. Javitt -- Inhalants / Charles W. Sharp and Neil L. Rosenberg -- Designer drugs / John P. Morgan -- MDMA / Charles S. Grob and Russell E. Poland -- Nicotine / Joy M. Schmitz and Katherine A. DeLaune -- Caffeine / Laura M. Juliano and Roland R. Griffiths -- Anabolic-androgenic steroids / Elyse R. Eisenberg and Gantt P. Galloway -- Prescription opiate abuse / Walter Ling, Donald R. Wesson, and David E. Smith -- IV. Related compulsive and addictive behaviors -- Eating disorders / Mark S. Gold Jodi Star -- Pathologic gambling / Sheila B. Blume and Hermano Tavares -- Addiction and cults: synthesizing a model for treating ex-members / Ron Burks -- Sexual addiction: nosology, diagnosis, etiology, and treatment / Aviel Goodman -- Internet/computer addiction / Zebulon Taintor -- Collecting, accumulation, and hoarding: acquisitions and their discontents / David A. Halperin and Jane Glick -- V. Evaluation and early treatment -- Diagnosis and classification: DSM-IV-TR and ICD-10 / John Cacciola and George E. Woody -- Diagnostic laboratory: screening for drug abuse / Karl G. Verebey, Gerard Meenan, and Betty J. Buchan -- VI. Treatment approaches -- Detoxification / Grace Chang and Thomas R. Kosten -- Alcoholics Anonymous / Edgar P. Nace -- Alternative support groups / Arthur T. Horvath -- The therapeutic community / William B. O'Brien and Fernando B. Perfas -- Methadone maintenance / Joyce H. Lowinson, Ira Marion, Herman Joseph, John Langrod, Edwin A Salsitz, J. Thomas Payte, and Vincent P. Dole -- Buprenorphine for the treatment of opioid addiction / Paul J. Fudala and Charles P. O'Brien -- Alternative pharmacotherapies for opioid addiction / Paul J. Fudala, Robert A. Greenstein, and Charles P. O'Brien -- Individual psychotherapy / Bruce J. Rounsaville, Kathleen M. Carroll, and Sudie Back -- Group therapy with outpatients / Arnold M. Washton -- Family/couples approaches to treatment engagement and therapy / M. Duncan Stanton and Anthony W. Heath -- The role of coercion in drug treatment / Sally L. Satel and David J. Farabee -- Treatment in prisons and jails / Roger H. Peters, Charles O. Matthews, and Joel A. Dvoskin -- Cognitive and behavioral therapies / Lisa M. Najavits, Bruce S. Liese, and Melanie S. Harned -- Network therapy / Marc Galanter -- Acupuncture / Ji-Sheng Han, Alan I. Trachtenberg, and Joyce H. Lowinson -- Faith-based approaches / John G. Langrod, John Muffler, James Abel, James T. Richardson, Eugenia Curet, Herman Joseph, and Pedro Ruiz -- Relapse prevention / Dennis C. Daley and G. Alan Marlatt -- Evaluation and outcome of treatment / Robert L. Hubbard -- VII. Management of associated medical conditions -- Maternal and neonatal effects of alcohol and drugs / Loretta P. Finnegan and Stephen R. Kandall -- Medical complications of drug use / Marc N. Gourevitch and Julia H. Arnsten -- Acute and chronic pain / Russell K. Portenoy, Richard Payne, and Steven D. Passik -- Substance use disorders in individuals with co-occurring psychiatric disorders / Sylvia J. Dennison -- VIII. HIV Infection and AIDS -- Epidemiology and emerging public health perspectives / Don C. Des Jarlais, Holly Hagan, and Samuel R. Friedman -- HIV-related medical complications and treatment / Chinazo O. Cunningham and Peter A. Selwyn -- Neuropsychiatric aspects of HIV- infection / Francisco Fernandez, Jorge Maldonado, and Pedro Ruiz -- Psychosocial issues of HIV/AIDS among drug users in treatment / James L. Sorensen, Nancy A. Haug, and Steven L. Batki -- IX. Life cycle -- Children of substance-abusing parents / Patti Juliana and Carolyn Goodman -- Adolescents / Andres J. Pumariega, Mark D. Kilgus, and Leonardo Rodriguez -- The elderly / Steven R. Gambert and Charles R. Albrecht III -- X. Women's issues -- Alcohol and women / Sheila B. Blume and Monica L. Zilberman -- Drugs and women / Monica L. Zilberman and Sheila B. Blume -- Women's research and policy issues / Marsha Rosenbaum and Sheigla Murphy -- XI. Ethnic populations -- African Americans: epidemiology, prevention, and treatment issues / Charles Madray, Lawrence S. Brown, Jr., and Beny J. Primm -- Hispanic Americans / Pedro Ruiz and John G. Langrod -- Asian Americans and Pacific Islanders / John W. Tsuang -- Alcohol use among American Indians and Alaskan Natives / Edward F. Foulks -- XII. Other populations -- Gays, lesbians, and bisexuals / Robert Paul Cabaj -- The homeless / Herman Joseph and John Langrod -- Disability and rehabilitation issues / Allen W. Heinemann and Purva H. Rawal -- Physicians and other health professionals / G. Douglas Talbott and Philip O. Wilson -- New immigrants and refugees / Joseph Westermeyer -- XIII. Models of prevention -- School-based programs / Gilbert J. Botvin and Kenneth W. Griffin -- Harm reduction: pragmatic drug policies for public health and safety / Ernest Drucker, Ethann Nadelman, Robert G. Newman, Alex Wodak, Jennifer McNeely, Kasia Malinowska-Semprucht, David Marsh, Martin Schechter, Bruna Brands, and Eugene Oscapella -- Church, family, and community in the prevention and treatment of addiction among African Americans / Ronald Hopson and William B. Lawson -- The public health approach to the prevention of substance abuse / Steven Jonas -- XIV. Training and education -- Medical education in substance abuse: the acquisition of knowledge, attitudes, and skills / John N. Chappel -- Education and training of clinical personnel / David A. Deitch, Igor Koutsenok, and Karin Marsolais -- Forensics / Milton Earl Burglass and Stuart Gitlow -- The role of neuropsychological assessment in forensic addiction / Ari D. Kalechstein, Wilfred G. van Gorp, and Garrett J. Zelen -- XV. Policy issues -- A new era for methadone advocacy / Joycelyn Woods, Walter Ginter, and Tony Scro -- The workplace / Paul F. Engelhart and Linda Barlow -- Treatment for alcohol and drug dependence: history, workforce, organization, financing, and emerging policies / Dennis McCarty and Howard H. Goldman -- Legal aspects of confidentiality of patient information / Margaret K. Brooks -- Clinical and societal implications of drug legalization / Herbert D. Kleber and James A. Inciardi -- Index.
  • 2015 Springer
    Alan David Kaye, Nalini Vadivelu, Richard D. Urman, editors.
    This book is written for any clinician who encounters substance abuse in a patient and wonders what to do. Experts from a cross-section of specialties and health professions provide up-to-date, evidence-based guidance on how non-expert clinicians can recognize, understand, and approach the management of substance abuse in their patients. They detail the range of treatments available and whether and how they work. The central importance of using a carefully selected multimodal approach that is tailored to the individual patient is emphasized throughout and illustrated in case scenarios from actual clinical practice.
  • 2014 Ovid
    Pedro Ruiz, Professor and Executive Vice-Chair, Director of Clinical Programs, Department of Psychiatry and Behavioral Sciences, Miller School of Medicine, University of Miami, Miami, Florida, Eric C. Strain, Professor, Director, Johns Hopkins Center for Substance Abuse Treatment and Research, Medical Director, Behavioral Pharmacology Research Unit, Johns Hopkins University School of Medicine, Baltimore, Maryland.
    "Stay up to date with the latest substance abuse treatments and modes of intervention with The Substance Abuse Handbook, 2e. The editors are both nationally recognized clinicians, and provide authoritative, clinically oriented information on the subject of substance use, abuse, and dependence, with an emphasis on diagnosis, treatment, and prevention.You'll find focused, expert information on every aspect of the field, including etiological factors; substances of abuse; compulsive and addictive behaviors; evaluation and diagnostic classification; treatment modalities, management of associated medical conditions; substance abuse in youth and the elderly; women's issue; special groups and settings; models of prevention; training and education; and policy issues. Succinctly presenting the most clinically relevant information from Lowinson and Ruiz's Substance Abuse, 5e, this concise, portable handbook is a must-have reference for anyone involved directly or indirectly in the addiction field.New to This Edition Find the practical information you need fast with this edition's focused coverage of basic science and greater emphasis on clinical concerns. Stay current with the latest information in the field, including changes reflecting the release of DSM-5. Access updated information in key topic areas, including "Special Populations," "Special Settings," and "Models of Prevention."-- Provided by publisher.
  • 2007 Ovid
    Pedro Ruiz, Eric C. Strain, John G. Langrod.
    I. Etiological factors -- 1. Determinants of substance abuse and dependence -- II. Substances of abuse -- 2. Alcohol -- 3. Opiates -- 4. Cocaine -- 5. Marijuana -- 6. Amphetamines and other stimulants -- 7. Sedative-hypnotics -- 8. Hallucinogens -- 9. Phencyclidine (pcp) -- 10. Inhalants -- 11. Mdma/designer drugs -- 12. Nicotine -- 13. Caffeine -- 14. Anabolic-androgenic steroids -- III. Compulsive and addictive behaviors -- 15. Eating disorders -- 16. Pathologic gambling -- 17. Sexual addiction -- IV. Evaluation and diagnostic classification -- 18. Classification, diagnosis and diagnostic laboratory -- V. Treatments modalities -- 19. Detoxification -- 20. Methadone treatment -- 21. Buprenorphine for the treatment of opioid addiction -- 22. Alternative pharmacotherapies for opioid addiction -- 23. Acupuncture -- 24. Individual psychotherapy -- 25. Group therapy -- 26. Family/couples approaches to treatment engagement and therapy -- 27. Cognitive and behavioral therapy -- 28. Alcoholics anonymous -- 29. The therapeutic community -- 30. Network therapy -- 31. Faith-based approaches -- 32. Relapse prevention -- 33. Treatment in prisons and jails -- VI. Management of associated medical conditions -- 34. Maternal and neonatal effects of alcohol and drugs -- 35. Medical complications of drug use -- 36. HIV infections and AIDS -- 37. Acute and chronic pain -- 38. Substance use disorders in individuals with co-occurring psychiatric disorders -- VII. Life cycle -- 39. Substance abuse and the life cycle: children, adolescents and the elderly -- VIII. Women's issues -- 40. Alcohol and drugs among women -- IX. Special groups/settings -- 41. Disability and rehabilitation issues -- 42. The workplace and methadone advocacy -- 43. Physicians and other health professionals -- X. Models of prevention -- 44. The public health approach to the prevention of substance abuse -- XI. Training and education -- 45. Medical education and Clinical Personnel Training -- 46. Forensics.
  • 2010 Springer
    H. Harrington Cleveland, Kitty S. Harris, Richard P. Wiebe, editors.
    The need for college recovery services / Richard P. Wiebe, H. Harrington Cleveland, and Kitty S. Harris -- Collegiate recovery communities : what they are and how they support recovery / Kitty S. Harris, Amanda Baker, and H. Harrington Cleveland -- Facilitating identity development in collegiate recovery : an Eriksonian perspective / Matthew Russell, H. Harrington Cleveland, and Richard P. Wiebe -- Characteristics of collegiate recovery community members / H. Harrington Cleveland, Amanda Baker, and Lukas R. Dean -- Maintaining abstinence in college : temptations and tactics / Richard P. Wiebe, H. Harrington Cleveland, and Lukas R. Dean -- Daily lives of young adult members of a collegiate recovery community / H. Harrington Cleveland and Allison Groenendyk -- How membership in the collegiate recovery community maximizes social support for abstinence and reduces risk of relapse / H. Harrington Cleveland, Richard P. Wiebe, and Jacquelyn D. Wiersma -- Building support for recovery into an academic curriculum : student reflections on the value of staff run seminars / Ann M. Casiraghi and Miriam Mulsow -- Establishing college-based recovery communities : opportunities and challenges encountered / Amanda Baker.
  • 2012 Cambridge
    Stephen M. Stahl, Meghan M. Grady, [illustrated by] Nancy Munter.
  • 2007 Ovid
    Stuart Gitlow.
    Pt. 1. General principles of substance use disorders -- An initial approach -- Types of use -- The substance use disorders -- Screening techniques -- The first interview -- Outpatient logistics -- Laboratory studies -- Pt. 2. Substance review -- Alcohol -- Other sedatives -- Sedative detoxification -- Medications during sedative recovery -- Nicotine -- Stimulants -- Opiates/opioids -- Opioid detoxification -- Opioid maintenance programs -- Marijuana -- LSD -- Other drugs -- Substance-induced disorders -- Pt. 3. Substance use treatment -- Treatment settings -- Twelve step programs -- Prevention -- Who treats substance use? -- Treatment dilemmas -- Patient placement criteria -- Legal issues -- Spirituality / by Stanley E. Gitlow.
  • 2005/2006
    Jennifer Ji-Van Tsui.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Neil Lineberry.
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    Enrico Marani, Tjitske Heida, Egbert A.J.F. Lakke, Kamen G. Usunoff ; edited by F. Beck, F. Clasc?, M. Frotscher, D.E. Haines, N. Hirokawa, Z. Kmiec, H.-W. Korf, E. Marani, R. Putz, Y. Sano, T.H. Schiebler, J.-P. Timmermans.
    Introduction -- Cytology of the subthalamic nucleus -- Ontogeny of the subthalamic nucleus -- Topography of the rat, cat, baboon, and human subthalamic nucleus -- Connections of the subthalamic nucleus -- Nigro-subthalamic connections in rat.
  • 2008 Springer
    Tjitske Heida, Enrico Marani, and Kamen G. Usunoff.
  • pt. A-C, 1971-75.
    edited by Serge N. Timasheff and Gerald D. Fasman.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Melina R. Kibbe, Scott A. LeMaire, editors.
    Academic surgeons play an essential role in advancing the field and improving the care of patients with surgical disease. As the Association for Academic Surgery (AAS) Fall Courses (www.aasurg.org) and international courses continue to evolve to address the rapidly expanding scope and complexity of academic surgery, there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Basic Science is a unique and portable handbook that focuses on the basic and translational research. It includes new educational materials that are necessary to address not only the rapid evolution and rise of novel research methodologies in basic science and translational research, but also the changing environment for academic surgeons. Success in Academic Surgery: Basic Science is a valuable text for medical students, surgical residents, junior faculty and others considering a career in surgical research.
  • 2014 Springer
    edited by Timothy M. Pawlik, Julie A. Sosa.
    Building Your Clinical Trial Research Team -- Clinical Trials: Ensuring Quality and Standardization -- Statistics: Setting the Stage -- Clinical Trials: Handling the Data -- Data Safety Monitoring Boards -- Planning for Data Monitoring and Audits -- The Budget -- Regulatory Considerations in Human Subjects Research -- Publishing a Clinical Trial -- Device Versus Drug Clinical Trials: Similarities and Important Differences -- Defining the Study Cohort: Inclusion and Exclusion Criteria -- The History of Clinical Trials -- Ethics of Clinical Trials -- Trial Design: Overview of Study Designs (Phase I, II, III, IV, Factorial Design).
  • 2013 Springer
    edited by Carla M. Pugh, Rebecca Sippel.
    Success in Academic Surgery: Developing a Career in Surgical Education is a unique and portable handbook that offers careers advice and guidance to medical students, surgical residents, young faculty and others considering a career within surgical education. Surgical education is a rapidly expanding area of surgical research and career interest, and as the Association for Academic Surgery (AAS) fall courses (www.aasurg.org) and international courses offer more and more specialty tracking there is a greater need for an accompanying textbook to supplement the material presented in the courses. Success in Academic Surgery: Developing a Career in Surgical Education expands on some of the important issues related to surgical education highlighted in the AAS courses by addressing key areas such as how to acquire the skills necessary for success in this field, how to develop a research program in surgical education as well as offering guidance on applying for research grants, among other things.
  • 2014 Springer
    Justin B. Dimick, Caprice C. Greenberg, editors.
    Success in Academic Surgery: Health Services Research is a unique handbook which will help researchers and surgeons in obtaining National Institutes of Health funding and other grants, as well as breaking through the barriers to developing a career in academic surgery. Aimed at surgical residents and young surgical faculty, Success in Academic Surgery: Health Services Research is written by expert authors from around the world who are members of the Association for Academic Surgery, and it offers a practical and personal insight on working in academic surgery.
  • 2012 Springer
    Herbert Chen, Lillian S. Kao (editors).
  • 2011
    Samir P. Desai, Rajani Katta.
    Status: Not Checked OutLane Catalog Record
    Introduction -- Internal medicine clerkship -- Surgery clerkship -- Pediatrics clerkship -- Psychiatry clerkship -- Obstetrics & gynecology clerkship -- Family medicine clerkship -- Patients -- The new rotation -- Admitting patients -- On call -- Laboratory tests -- Ancillary tests -- Attending rounds -- Oral case presentations -- Write-ups -- The outpatient setting -- Evaluations -- The written exam -- Rotation success -- Attendings -- Working as a team -- Giving talks.
  • 2006 ScienceDirect
    edited by Peggy A. Pritchard.
    Career management / Peggy A. Pritchard -- Continuing professional development / Christine Faerber and Anngienetta Johnson -- Training and working abroad / Mary Osborn -- Climbing the ladder / Ilene J. Busch-Vishniac -- Mentoring / Christine S. Grant -- Networking / Patricia Rankin and Joyce McCarl Nielsen -- Mental toughness / Peggy A. Pritchard -- Personal style / M. Elizabeth Cannon and Kathleen Sendall -- Communicating science / Christine Szymanski -- Time stress / Peggy A. Pritchard -- Balancing professional and personal life / Sarah E. Randolph ... [et al.] -- Transitions / Margaret Ann-Armour and Dorothy Tovell.
  • 2014 Karger
    volume editors,Solange Peters, Rolf A. Stahel.
    Targeting oncogenic drivers / Zhao, Y.; Adjei, A.A. (Buffalo, N.Y.) -- Successes and limitations of targeted cancer therapy in breast cancer / Curigliano, G.; Criscitiello, C. (Milan) -- Successes and limitations of targeted cancer therapy in colon cancer / Khne, C.-H. (Oldenburg) -- Successes and limitations of targeted cancer therapy in gastrointestinal stromal tumors / Casali, P.G. (Milano) -- Successes and limitations of targeted cancer therapy in lung cancer / Suda, K. (Osaka-Sayama/Fukuoka); Mitsudomi, T. (Osaka-Sayama) -- Successes and limitations of targeted cancer therapy in melanoma / Romano, R.; Michielin, O. (Lausanne) -- / successes and limitations of targeted cancer therapy in ovarian cancer / Damia, G. (Milan); Sessa, C. (Bellinzona) -- Successes and limitations of targeted therapies in renal cell carcinoma / Pracht, M.; Berthold, D. (Lausanne).
  • 2010 CRCnetBASE
    Colleen Stukenberg.
    Building trust and communication -- Impacts : quality and financial -- Clinical documentation specialist : who is involved and what is the process? -- Clinical documentation specialist and education -- Collaboration with hospital case management -- Putting it all together -- Final thoughts.
  • 2008 ebrary
    Laura N. Gitlin, Kevin J. Lyons.
    Why write a grant? -- Becoming familiar with funding sources -- Developing your ideas for funding -- Common sections of proposals -- Strategies for effective writing -- Technical writing considerations -- Developing a budget -- Putting it all together to create a budget -- Technical considerations in budget development -- Four project structures -- Understanding the process of collaboration -- Forming a collaborative team -- Learning about your institution -- Electronic considerations -- Understanding the review process -- Responding to the proposal review -- A case study -- Welcome to the world of post-award -- More post-award considerations.
    Also available: Print – 2008
  • 2009
    Rajani Katta, Samir P. Desai.
    The application -- Specialty-specific information -- The basics -- Selection process -- The right fit -- Curriculum vitae (CV) -- Letters of recommendation -- Personal statement -- Dean's letter (MSPE) -- The audition elective -- The competitive edge -- Before the interview -- Interview questions -- The interview day -- After the interview -- Ranking residency programs -- International medical graduates.
  • 2014 Cambridge
    Janice R. Matthews, Robert W. Matthews.
    "The authors draw on 50 years of experience, providing detailed step-by-step guidance designed to help students and researchers write and present scientific manuscripts more successfully through knowledge, practice, and an efficient approach."--Publisher description.
  • 2008
    Janice R. Mathews and Robert W. Matthews.
    Preparing to write -- Composing a first draft -- Visual support for the written word -- Visual support for the spoken word -- Revising to increase coherence -- Improving word choice, and syntax style -- Attending to grammar, numbers, and other mechanics -- The rest of the story.
  • 2009 ebrary
    edited by Peter A. Hall, Michèle Lamont.
    Why are some societies more successful than others at promoting individual and collective well-being? This book integrates recent research in social epidemiology with broader perspectives in social science to explore why some societies are more successful than others at securing population health. It explores the social roots of health inequalities, arguing that inequalities in health are based not only on economic inequalities, but on the structure of social relations. It develops sophisticated new perspectives on social relations, which emphasize the ways in which cultural frameworks as well as institutions condition people's health. It reports on research into health inequalities in the developed and developing worlds, covering a wide range of national case studies, and into the ways in which social relations condition the effectiveness of public policies aimed at improving health.
  • 2016 Springer
    Gaetano Thiene, Domenico Corrado, Cristina Basso.
    This text atlas focuses on the pathology and molecular genetics of sudden cardiac death in the young and in athletes, presenting the state of the art in the field as the basis for development and implementation of more effective prevention strategies, including, ultimately, molecular therapy that will cure the underlying biological defect. A wealth of high-resolution color images, accompanied by clear supporting text, are presented to document the anatomic pathology of the cardiac diseases most frequently responsible for sudden cardiac death in this population, including coronary artery diseases, cardiomyopathies, myocarditis, valve diseases, conduction system abnormalities, congenital heart diseases, and ion channel diseases. The role of the molecular autopsy in overcoming the limitations of morphological investigations and offering new insights and avenues for prevention is explained. The approach is, however, interdisciplinary, with close attention also to epidemiologic and clinical aspects. The authors draw throughout on their experience gained over 30 years in the course of a prospective study carried out in the Veneto Region, North East Italy. This text atlas will be of great value not only for cardiologists but also for geneticists, sports physicians, and residents in cardiology and pathology.
  • 2011 CRCnetBASE
    edited by Claire M. Lathers, Paul L. Schraeder, Michael W. Bungo, Jan E. Leestma.
  • 2006 Springer
    edited by Darrell L. Ross, Theodore C. Chan.
    Medical overview of sudden in-custody deaths / Theodore C. Chan -- The nature of sudden custodial deaths / Darrell L. Ross -- Neck holds / Gary M. Vilke -- Positional and restraint asphyxia / Tom Neuman -- Restraint stress / Elizabeth A. Laposata -- The role of illicit drug use in sudden in-custody death / Aaron B. Schneir and Richard F. Clark -- Excited delirium / Charles V. Wetli -- Riot control agents, taser, and other less lethal weapons / Christian Sloane and Gary M. Vilke -- Case analysis of restraint deaths in law enforcement and corrections / Darrell L. Ross -- Deaths in custody investigations / Vincent Dimiao -- Liability and wrongful custodial deaths / Darrell L. Ross -- Administrative implications / Darrell L. Ross.
  • 2014 Springer
    Toshiko Sawaguchi, editor.
    Sudden infant death syndrome (SIDS) is characterised by the sudden death of an infant that is not predicted by prior medical history and it is still responsible for a large percentage of infant mortalities. The exact causes have long remained unknown, though some risk factors such as including exposure to tobacco smoke, no breast feeding, and prone sleeping position, have been identified. However an analysis linking neurophysiological and neuropathological aspects in a prospective study of SIDS suggests that one of the causes of SIDS is arousal deficiency. This unique book provides the latest, comprehensive information on SIDS research from epidemiology to physiology.
  • ScienceDirect
    edited by William B. Jakoby, Owen W. Griffith.
    Also available: Print – 1987
  • Google Books
    Also available: Print – v. 1, 1953-.
  • 2010
    by Molly Cooke, David M. Irby and Bridget C. O'Brien.
    The article is a summary of a study that was "part of a larger program of research by The Carnegie Foundation for the Advancement of Teaching on preparation for the professions"--Website.
  • NAP
    Frederick J. Manning, Board on Health Sciences Policy, Institute of Medicine.
    Recapping the Graylyn Report -- Primary thoughts on data collection -- Invited talks on the clinical investigator workforce -- Comments on the clinical research workforce by Roundtable responders -- Future work.
  • 2008 Springer
    edited by Jörg Reichrath.
    Also available: Print – 2008
  • 2014
    edited by Jörg Reichrath.
    "The goal of this volume is to comprehensively cover a highly readable, updated and extended, overview on our present knowledge of positive and negative effects of UV-exposure, with a focus on vitamin D and skin cancer. Topics that are discussed in-depth by leading researchers and clinicians range from the newest findings in endocrinology, epidemiology, histology, photobiology, immunology, cytogenetics and molecular pathology to new concepts for prophylaxis and treatment. Experts in the field as well as health care professionals not intimately involved in these specialized areas are provided with the most significant and timely information related to these topics. It is the aim of the second edition of this book to summarize essential up-to-date information for every clinician or scientist interested in how to balance between positive and negative effects of UV-exposure to minimize the risks of developing vitamin D deficiency and skin cancer"--Publisher's description.
  • 2007 Karger
    volume editor: Gianni Marone.
    Also available: Print – 2007
  • 2008 Wellcome Trust
    edited by L.A Reynolds and E.M. Tansey.
  • 2014 CRCnetBASE
    edited by Gregory K. Webster.
    The SFC market : "yesterday, today, and tomorrow" -- The use of SFC in discovery sciences -- Qualification of SFC hardware and validation of systems -- Method development for achiral SFC -- Achiral preparative supercritical fluid chromatography -- Supercritical fluid chromatography for chiral method development screening and analysis -- Chiral preparative supercritical fluid chromatography -- SFC in process analytical chemistry -- Analytical SFC for impurities -- Supercritical fluid chromatography -- mass spectrometry -- Supercritical fluid chromatography of natural products -- Polarimetric detection in supercritical fluid chromatography -- Supercritical fluid chromatography with ultra-performance particles -- Pilot and production-scale supercritical fluid chromatography.
  • 2008 CRCnetBASE
    edited by Jose L. Martinez.
    Fundamentals of supercritical fluid technology / Pereda, S., Bottini, S.B. and Brignole, E. -- Supercritical extraction plants / Martinez, J.L. and Vance, S. -- Supercritical fluid extraction of specialty oils / Temelli, F. ... [et al.] -- Extraction and purification of natural tocopherols by supercritical CO / Fang, T. ... [et al.] -- Processing of fish oils by supercritical fluids / Eltringham, W. and Catchpole, O.J. -- Supercritical fluid extraction of active compounds from algae / Mendes, R. -- Application of supercritical fluids in traditional Chinese medicines and natural products / Li, S. -- Extraction of bioactive compounds from Latin American plants / Meireles, M.A. -- Antioxidant extraction by supercritical fluids / Diaz-Reinoso, B. ... [et al.] -- Essential oils extraction and fractionation using supercritical fluids / Reverchon, E. and De Marco, I. -- Processing of spices using supercritical fluids / Mukhopadhyay, M. -- Preparation and processing of micro and nano-scale materials by supercritical fluid technology / Weidner, W. and Petermann, M.
  • 2009 Springer
    edited by Katalin Balogh, Attila Patocs.
    MEN1 clinical background / Peter Igaz -- Genetic background of MEN1 : from genetic homogeneity to functional diversity / Patrick Gaudray and Günther Weber -- Menin : the protein behind the MEN1 syndrome / Maria Papaconstantinou ... [et al.] -- Cellular functions of menin / Geoffrey N. Hendy, Hiroshi Kaji and Lucie Canaff -- The role of menin in hematopoiesis / Ivan Maillard and Jay L. Hess -- Role of menin in bone development / Hiroshi Kaji, Lucie Canaff and Geoffrey N. Hendy -- Activin, TGF-€ and menin in pituitary tumorigenesis / Jean-Jacques Lebrun -- The role of menin in parathyroid tumorigenesis / Colin Davenport and Amar Agha -- Role of menin in neuroendocrine tumorigenesis / Terry C. Lairmore and Herbert Chen -- Adrenal tumors in MEN1 syndrome and the role of menin in adrenal tumorigenesis / Attila Patocs, Katalin Balogh and Karoly Racz -- Functional studies of menin through genetic manipulation of the MEN1 homolog in mice / Dheepa Balasubramanian and Peter C. Scacheri.
    Also available: Print – 2009
  • 2002 ScienceDirect
    edited by Lester Packer ; editorial advisory board, Joe M. McCord, Irwin Fridovich.
    Also available: Print – 2002
  • 2014 Springer Protocols
    edited by Eugenio F. Fornasiero, Silvio O. Rizzoli.
    Light Microscopy and Resolution -- Super-Resolution Microscopy: Principles, Techniques, and Applications -- Foundations of STED Microscopy -- Application of Real-Time STED Imaging to Synaptic Vesicle Motion -- Photoactivated Localization Microscopy for Cellular Imaging -- Data Analysis for Single-Molecule Localization Microscopy -- Super-Resolution Fluorescence Microscopy Using Structured Illumination -- Application of Three-Dimensional Structured Illumination Microscopy in Cell Biology: Pitfalls and Practical Considerations -- Scanning Near-Field Optical Microscopy for Investigations of Bio-Matter -- Atomic Force Microscopy of Living Cells -- X-Ray Microscopy for Neuroscience: Novel Opportunities by Coherent Optics -- Nonlinear Optics Approaches Towards Sub-Diffraction Resolution in CARS Imaging -- Photo-Oxidation Microscopy: Bridging the Gap Between Fluorescence and Electron Microscopy -- Requirements for Samples in Super-Resolution Fluorescence Microscopy -- Probing Biological Samples in High-Resolution Microscopy: Making Sense of Spots.
  • 2014 Springer
    Cesare Marco Scoffone, Andras Hoznek, Cecilia Maria Cracco, editors.
    PNL is the gold standard for the management of large and/or otherwise complex renal stones. Since its introduction in the seventies PNL has undergone considerable evolution, mainly driven by the improvement in access techniques, endoscopic instrument technology, lithotripsy devices and drainage management. The conventional prone position for PNL has been challenged in the last two decades by a variety of modifications, including the supine and Galdakao-modified supine Valdivia positions, which make simultaneous retrograde working access to the collecting system possible and have proven anesthesiological advantages. The Galdakao-modified supine Valdivia position allowed the development of ECIRS (Endoscopic Combined IntraRenal Surgery), a technique exploiting a combined antegrade and retrograde approach to the upper urinary tract, using both rigid and flexible endoscopes with the related accessories. The synergistic teamwork of ECIRS provides a safe and efficient, minimally-invasive procedure for the treatment of all kinds of urolithiasis. The aim of this book is to share with the urologic community worldwide our experience, our standardization of all the steps, and tips and tricks for the procedure.
  • 2010 Springer
    William C.S. Cho, editor.
  • 2015 Springer
    James H. Feusner, Caroline A. Hastings, Anurag K. Agrawal, editors.
    1. Febrile neutropenia -- 2. Transfusion support -- 3. Tumor lysis syndrome -- 4. Cardiopulmonary emergencies -- 5. Neurologic emergencies -- 6. Hyperleukocytosis -- 7. The acute abdomen -- 8. Thrombotic disorders -- 9. Pain management -- 10. Nausea and vomiting -- 11. Oral mouth care and mucositis -- 12. Nutrition -- 13. Management of acute radiation side effects -- 14. Prevention of infection -- 15. Hematopoietic growth factors -- 16. Immunization practice in pediatric oncology -- 17. Central venous catheters: care and complications -- 18. Knowledge gaps and opportunities for research.
  • 2011 ScienceDirect
    2011 ClinicalKey
    Mellar P. Davis, Petra Ch. Feyer, Petra Ortner, Camilla Zimmermann.
  • 2010 Springer
    Anthony Hudetz, Robert Pearce, editors.
  • v.1, 2=, 2010, 2016 Springer Protocols
    v.2 (2016) Springer Protocols
    edited by Maria Cristina Cuturi and Ignacio Anegon.
  • 2008
    J. S. P. Lumley.
    Status: Not Checked OutLane Catalog Record
  • 2006 CRCnetBASE
    edited by Ryan Richards.
  • 1938.
    by A.B. Appleton [and others].
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Fulltext Springer
    edited by, Mark J. Jackson, Waqar Ahmed.
  • 2014 CRCnetBASE
    edited by Ahmad Fadzil Mohamad Hani.
    Skin surface roughness measurement for assessing scaliness of psoriasis lesions -- Ahmad Fadzil Mohamad Hani and Esa Prakasa -- Determination of lesion color for clustering psoriasis erythema / Ahmad Fadzil Mohamad Hani, Esa Prakasa -- Body surface area measurement for lesion area assessment / Ahmad Fadzil Mohamad Hani and Esa Prakasa -- Skin lesion thickness assessment / Ahmad Fadzil M. Hani and Hurriyatul Fitriyah -- Analysis of skin pigmentation / Ahmad Fadzil M. Hani and Hermawan Nugroho -- Quantitative assessment of ulcer wound volume / Ahmad Majdi A. Rani, Ahmad Fadzil M. Hani, Nejood El-Tegani, Evan Chongand Ankur Sagar -- Enhancement and segmentation of acne vulgaris lesions / Aamir Saeed Malik, Jawad Humayun, Felix Boon-Bin Yap, and Javed Khan.
  • 2006 Springer
    volume editor, Jiří Homola ; with contributions by J. Dostálek ... [et al.].
  • 2005 CRCnetBASE
    edited by Pankaj Vadgama.
  • v. 78, 80, 89, 93, 95-96, 100, 102-103, 105, 108-117, 119-, 1999- CRCnetBase
    Schick, Martin J.
  • NLM
    Also available: Print – 1988
  • v. 1-2, 1979-
    by Karel B. Absolon.
    Status: Not Checked OutLane Catalog Record
  • 2009 ClinicalKey
    [edited by] Barry D. Mann.
    Designed to teach you to think like an experienced clinician, this unique resource places as much value on process as it does on content. A case-based organization hones in on the must-know differential diagnoses of the common surgical presentations. Its convenient pocket-sized format enables you to review the material on the go, and online access via Student Consult enhances your study of the material and exponentially boosts your reference power. Provides high-yield core information essential to surgical rotations in a portable, pocket-sized format.Uses a color-coded system that places the core surgical information in a framework of the ACGME Core Competencies.Offers self-assessment activities throughout to promote retention and application of knowledge, including access on line to your own competency-based portfolio tools and competency-specific learning modules (Vertical Reads).Features ACGME Core Competencies enabling you to integrate evidence based medicine, continual self-assessment, and cognizance of interpersonal skills into your daily routine.Includes features such as "Speaking Intelligently" and "Clinical Thinking" in each chapter to help you see the "big picture."Organizes the most common and must-know surgical signs/symptoms and disorders by presentation, making reference simple.Presents "Teaching Visuals"-an interactive teaching device designed to reinforce visual concepts.Equips you to perform a more in-depth review of surgical topics with "Clinical Entities" that are referenced to top surgical references.
  • 2008 Springer
    edited by Jeffrey A. Norton ... [et al.].
    Also available: Print – 2008
  • 2009
    edited by Nigel Rawlinson, Derek Alderson.
    Status: Not Checked OutLane Catalog Record
  • 2009
    [edited by] Lillian S. Kao, Tammy Lee.
    Status: Not Checked OutLane Catalog Record
    Pre and postoperative care -- Critical care : anesthesiology, blood gases, and respiratory care -- Skin : wounds, infections, and burns : hands : plastic surgery -- Trauma and shock -- Transplants, immunology, and oncology -- Endocrine problems and the breast -- Gastrointestinal tract, liver, and pancreas -- Cardiothoracic problems -- Peripheral vascular problems -- Urology -- Orthopedics -- Neurosurgery -- Otolaryngology -- Pediatric surgery.
  • 2006
    [edited by] Lillian S. Kao.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Christian de Virgilio, editor ; Areg Gregorian, associate editor ; Paul N. Frank, assistant editor.
    Surgery: A Case Based Clinical Review provides the reader with a comprehensive understanding of surgical diseases in one easy-to-use reference that combines multiple teaching formats. The book begins using a case based approach. The cases presented cover the diseases most commonly encountered on a surgical rotation. The cases are followed by a series of short questions and answers, designed to provide further understanding of the important aspects of the history, physical examination, differential diagnosis, diagnostic work-up and management, and questions that may arise on surgical rounds. Key figures and tables visually reinforce the important elements of the disease process. Surgery: A Case Based Clinical Review will be of great utility for medical students when they rotate on surgery, interns, physician assistant students, nursing students, and nurse practitioner students.
  • 2014 Springer
    Umut Sarpel.
    Surgery: An Introductory Guide is an all-in-one reference that provides the vital information needed to get the best learning experience out of an operation, and presents it in a convenient, efficient, and portable format. Each section brings together the key points from several different fields including anatomy, pathophysiology, radiology, surgical technique, and clinical guidelines. The operations covered represent the breadth of general surgery including hernia repair, cholecystectomy, breast surgery, general bowel surgery, and vascular surgery. Each chapter provides informative text, bulleted lists, and common OR questions, combined with classic radiology images, diagrams, and a color illustration of the operative anatomy. This method of using key words, high-yield diagrams, and illustrations enhances the ability to quickly absorb and retain the relevant information. The volume is also organized by operation rather than by pathological topic, which lends itself to quick review before each case. Written by Dr. Sarpel, a surgeon and former co-clerkship director who has been honored with multiple teaching awards, Surgery: An Introductory Guide is of great value to medical students and junior residents rotating on general surgery.
  • 2006
    Pierce A. Grace, Neil R. Borley.
    Status: Not Checked OutLane Catalog Record
    Abdominal hernias -- Gallstone disease -- Pancreatitis -- Pancreatic tumours -- Benign breast disease -- Breast cancer -- Goitre -- Thyroid malignancies -- Parathyroid disease -- Pituitary disorders -- Adrenal disorders -- Skin cancer -- Ischaemic heart disease -- Valvular heart disease -- Peripheral occlusive vascular disease -- The diabetic foot -- Aneurysms -- Extracranial arterial disease -- Deep venous thrombosis -- Varicose veins -- Lymphoedema -- Pulmonary collapse and postoperative pneumonia -- Bronchial carcinoma -- Urinary tract infection -- Benign prostatic hypertrophy -- Renal calculi -- Renal cell carcinoma -- Carcinoma of the bladder -- Carcinoma of the prostate -- Testicular cancer -- Urinary incontinence -- Paediatric 'general' surgery -- Solid organ transplantation. Neck lump -- Dysphagia -- Haemoptysis -- Breast lump -- Breast pain -- Nipple discharge -- Haematemesis -- Dyspepsia -- Vomiting -- Acute abdominal pain -- Chronic abdominal pain -- Abdominal swellings (general) -- Abdominal swellings (localized) : upper abdominal -- Abdominal swellings (localized) : lower abdominal -- Jaundice -- Rectal bleeding -- Diarrhoea -- Altered bowel habitconstipation -- Groin swellings -- Claudication -- Acute warm painful leg -- Acute 'cold' leg -- Leg ulceration -- Dysuria -- Urinary retention -- Haematuria -- Scrotal swellings -- Stomas and incisions -- Anaesthesia -- Hypoxia -- Shock -- Systemic inflammatory response syndrome (SIRS) -- Surgical infection -- Acute renal failure -- Fractures -- Burns -- Major trauma - basic principles -- Head injury -- Gastro-oesophageal reflux -- Oesophageal carcinoma -- Peptic ulceration -- Gastric carcinoma -- Malabsorption -- Crohn's disease -- Acute appendicitis -- Diverticular disease -- Ulcerative colitis -- Colorectal carcinoma -- Benign anal and perianal disorders -- Intestinal obstruction --
  • 2016 Springer
    COL Robert B. Lim, editor.
    Disaster Medicine: Lessons Learned from the Crash of Asiana Airlines Flight -- Disaster Preparedness -- Trauma Surgery in an Austere Environment: Trauma and Emergency Surgery in Unusual -- Difficult Triage Decisions in the Combat or Austere -- Removal of Unexploded -- Hostage Rescue -- Awake Tracheostomy in an Austere -- Pediatric Emergencies in the Combat or Austere Environment: As Easy as A, B, C -- The Oklahoma City -- The Experience of Disaster Response in Sri Lanka: From Reaction to Planning -- A Surgical Response to the Haiti Earthquake -- Surgery on Public Enemy #1 -- Lessons Learned in Combat Burn -- Operating in a Tent -- Dismounted Complex Blast -- Surgery Under Fire -- Lessons Learned From the Boston Marathon Bombing -- Chemical Warfare: A Brief History and Summary of Current Threats and Initial Management -- Providing Surgical Training and Assistance in a Developing Country during Military Assistance -- Use What You?ve Got: Resource Utilization in a Mass Casualty in Afghanistan. .
  • 2015 Springer
    Joseph Kim, Julio Garcia-Aguilar, editors.
    This book provides an educational resource of modern and advanced operative techniques for patients with GI cancers. The textbook is designed to provide a step-by-step surgical approach, highlighting key learning points and potential operative pitfalls. When appropriate, two or more different approaches on an operative procedure are presented to provide additional perspective on surgical techniques. Written descriptions of laparoscopic and robotic cancer operations are paired with online video presentations of the same cancer operation. Written by experts in the field, Surgery for Cancers of the Gastrointestinal Tract: A Step-by-Step Approach provides a concise summary of the current management of each GI cancer and is of great utility to not only surgeons at all levels of training, but also for surgeons in practice who seek to reinforce or learn new surgical techniques.
  • 2016 Thieme-Connect
    Mario Sanna, Rolien Free, Paul Merkus, Maurizio Falcioni.
    History of auditory implantation -- Surgical anatomy in auditory implantation -- Radiology in auditory implantation -- Instruments and implants -- Cochlear implantation -- Special considerations in pediatric cochlear implantation -- Complications and revision surgery in cochlear implantation -- Auditory brainstem implantation -- Electroacoustic stimulation -- Subtotal petrosectomy in cochlear implantation -- Cochlear implantation in cochlear ossification -- Meningitis and implantation -- Auditory implantation in otosclerosis patients -- Otomastoiditis and cochlear implantation -- Inner ear malformations and implantation -- Neurofibromatosis type 2 and auditory implantation -- Implantation in skull base and temporal bone lesions -- Bone conduction implants -- Active middle ear implants : vibrant soundbridge.
  • 2010 Springer
    Marek Szpalski, Robert Gunzburg, Björn L. Rydevik, Jean-Charles Le Huec, H. Michael Mayer (eds.).
  • 2006
    edited by Robert E. Bristow and Beth Y. Karlan.
    Status: Not Checked OutLane Catalog Record
  • 2015 Karger
    volume editors, Nikhila Raol, Christopher J. Hartnick.
    Anatomy and physiology of velopharyngeal closure and insufficiency / Raol, N., Hartnick, C.J -- Nasometry, videofluoroscopy, and the speech pathologist's evaluation and treatment / de Stadler, M., Hersh, C. -- Nasal endoscopy : new tools and technology for accurate assessment / Raol, N. -- New technology : use of cine MRI for velopharyngeal insufficiency / Raol, N., Sagar, P., Nimkin, K., Hartnick, C.J -- Validated patient-reported outcome instruments for velopharyngeal insufficiency / Skriko, J.R., Sie, K.C.Y. -- Prosthodontics rehabilitation in velopharyngeal insufficiency / Jackson, M. -- Superiorly based pharyngeal flap / Raol, N., Hartnick, C.J. -- Sphincter pharyngoplasty / Raol, N., Hartnick, C.J. -- Furlow double-opposing z-plasty / Raol, N., Hartnick, C.J. -- Posterior pharyngeal wall augmentation / Perez, C.F., Brigger, M.T. -- Persistent velopharyngeal insufficiency / Willging, J.P. -- Obstructive sleep apnea / Willging, J.P.
  • 2010 Springer
    Karl Hörmann, Thomas Verse.
    Sleep Disordered Breathing / Kerstin Rohde and Thomas Verse -- General Aspects of Therapy / Thomas Verse -- Identifying the Site of Obstruction / Joachim T. Maurer and Thomas Verse -- Nasal Surgery / Thomas Verse and Wolfgang Pirsig -- Nasopharyngeal Surgery / Thomas Verse and Wolfgang Pirsig -- Palatal Surgery / Thomas Verse, Wolfgang Pirsig and Joachim T. Maurer -- Lower Pharyngeal Airway Procedures / Boris A. Stuck, Thomas Verse, Nico de Vries and Joachim T. Maurer -- Maxillofacial Surgeries / Thomas Verse and Thomas Hierl -- Laryngeal OSA / Thomas Verse -- Multilevel Surgery / Thomas Verse -- Tracheotomy / Thomas Verse and Wolfgang Pirsig -- Bariatric Surgery / Helge Kleinhans and Thomas Verse -- Anesthesiologic Airway Management / Harald V. Genzwuerker.
  • 2005 Springer
    Karl Hörmann, Thomas Verse.
  • 2008 Karger
    volume editors, Gerd Geerling, Horst Brewitt.
    Surgery for the dry eye? / Geerling, G., Brewitt, H. -- The normal tear film / Tiffany, J.M. -- Functional anatomy and immunological interactions of ocular surface and adnexa / Paulsen, F. -- Classification and diagnosis of dry eye / Kaercher, T., Bron, A.J. -- Medical management of the dry eye disease / Tuft, S., Lakhani, S. -- Anti-inflammatory and immunosuppressive concepts / Nölle, B. -- Correction of entropion and ectropiona / Hintschich, C. -- Correction of lid retraction and exophthalmos / Baldeschi, L. -- Lacrimal drainage surgery in a patient with dry eyes / Rose, G.E. -- Surgery of the conjunctiva / Yokoi, N., Inatomi, T., Kinoshita, S. -- Surgery of the cornea : corneal, limbal stem cell, and amniotic membrane transplantation / Kruse, F.E., Cursiefe, C. -- Keratoprosthesis surgery / Liu, C. ... [et al.] -- Eyelid botulinum toxin injections for the dry eye / Sahlin, S., Linderoth, R. -- Plugs for occlusion of the lacrimal drainage system / Tost, F.H.W., Geerling, G. -- Surgical occlusion of the lacrimal drainage system / Geerling, G., Tost, F.H.W. -- Mucous membrane grafting / Henderson, H.W.A., Collin, J.R.O. -- Minor salivary gland transplantation / Geerling, G., Raus, P., Murube, J. Transplantation of the major salivary glands / Geerling, G., Sieg, P. -- Mechanical pump dacryoreservoirs / Murube, J., Geerling, G. -- Clinical trials in dry eye in surgery for dry eye? / Lemp, M.A. -- Animal models of dry eye / Schrader, S., Mircheff, A.K., Geerling, G. -- Flow chart on surgical approaches to dry eye / Geerling, G., Brewitt, H.
    Also available: Print – 2008
  • 2015 Springer
    Bruce E. Dall, Sonia V. Eden, Michael D. Rahl, editors.
    Filling a significant knowledge gap, this book brings the latest information to the evaluation and treatment of patients with a dysfunctional sacroiliac (SI) joint. Beginning with an overview of current anatomical knowledge and the role of pain and surgery, diagnosis and treatment approaches are carefully presented as individual chapters - featuring the origin of each surgical approach, the approach itself, its literary foundation, and overall available results. The final emphasis of the book is on post-operative concerns - including complications, bracing options, rehabilitation and managing patient expectations. Spine surgeons, physical therapists, and other professionals who treat the SI joint will find Surgery for the Painful, Dysfunctional Sacroiliac Joint to be an invaluable resource.
  • 2013 ClinicalKey
    Roger Dmochowski, Mickey Karram, W. Stuart Reynolds ; illustrated by Joe Chovan.
    Etiology and epidemiology of urinary incontinence / W. Stuart Reynolds -- Preoperative evaluation of patients with urinary incontinence and selection of appropriate surgical procedures for stress incontinence / W. Stuart Reynolds Mickey Karram -- Surgical anatomy of the anterior vaginal wall, retropubic space, and inner groin / Mickey Karram -- Retropubic operations for stress urinary incontinence / Mark D. Walters -- Biologic bladder neck pubovaginal slings / Mickey Karram, Dani Zoorob, and W. Stuart Reynolds -- Retropubic synthetic midurethral slings / Mickey Karram, Dani Zoorob, and W. Stuart Reynolds -- Transobturator synthetic midurethral slings / Dani Zoorob and Mickey Karram -- Single incision minislings / Mickey Karram, W. Stuart Reynolds, and Dani Zoorob -- Surgical management of voiding dysfunction and retention after stress incontinence surgery / Mickey Karram -- Bulk enhancing agents for stress incontinence : indications and techniques / Roger Dmochowski -- Sacral neuromodulation / W. Stuart Reynolds and Roger Dmochowski -- Botulinum toxin injection therapy / W. Stuart Reynolds and Roger Dmochowski -- Bladder augmentation / W. Stuart Reynolds and Roger Dmochowski -- Mixed and recurrent incontinence, incontinence in patients with pelvic organ prolapse, and how best to avoid and manage complications; case discussions / Mickey Karram, W. Stuart Reynolds, and Roger Dmochowski.
  • 2009 Springer
    [edited by] Antonio Bolognese, Luciano Izzo.
  • 2012 Springer
    Giovanni de Manzoni, Franco Roviello, Walter Siquini, editors ; foreword by Keiichi Maruyama.
    Although there has been a slow but steady decrease in incidence, gastric cancer remains the second leading cause of cancer death worldwide. Several aspects of the oncological and surgical management are still controversial and so gastric cancer represents a challenge for the surgeon. This book aims to delineate the state of the art in the surgical and oncological treatment of gastric cancer, describing the new TNM staging system, the extent of visceral resection and lymphadenectomy focusing on the different open and minimally invasive surgical techniques and discussing intraoperative chemohyperthermia and neoadjuvant and adjuvant treatment. Operative endoscopy and endoscopic ultrasonography are also discussed, as these now have an important role in both diagnostic work-up and palliative care of gastric cancer patients. Only a multidisciplinary approach involving the surgeon, gastroenterologist, and oncologist can produce the comprehensive and integrated overview that today constitutes a winning strategy for the optimization of results.What we hope we have achieved is a flexible, up-to-date, exhaustive publication, rich in illustrations and consistent with evidence-based medicine.
  • 2013 Springer
    Madjid Samii, Venelin Gerganov ; with chapters on microsurgical anatomy by A.L. Rhoton and neuropathology by G.F. Walter.
    History of cerebellopontine angle surgery -- Microsurgical anatomy of the cerebellopontine angle by the retrosigmoid approach -- Neuropathology of the cerebellopontine angle and its surroundings -- Approaches to the cerebellopontine angle -- Vestibular schwannomas -- Neurofibromatosis Type 2 and other bilateral cerebellopontine angle tumors -- Meningiomas -- Cerebellopontine angle epidermoids -- Nonvestibular schwannomas -- Jugular foramen tumors -- Other cerebellopontine angle tumors -- Management of facial palsy.
  • 2008 Springer
    Robert Carachi, Jay L. Grosfeld, Amir F. Azmy (eds.).
  • 2013 Springer
    Rifat Latifi, editor.
  • 2016 Springer
    Lacour-Gayet, Francois; Bove, Edward L.; Hraška, Viktor; Morell, Victor O.; Spray, Thomas L.
    This book addresses the most technically demanding cardiac surgical techniques, many of which are often performed on small infants. Conotruncal heart defects are a group of congenital anomalies of the cardiovascular system that are a leading cause of symptomatic cyanotic cardiac disease diagnosed in utero. Surgery of Conotruncal Anomalies provides a wealth of practical information and has been written by a collection of world renowned experts. They discuss the most challenging but life-changing surgeries which, if performed perfectly, allow the child to lead a normal adult life in the majority of cases. This book and the large number of truly stunning explanatory illustrations contained within is an essential resource for junior surgeons as well as trainees and practicing cardiac surgeons, pediatric cardiologists and surgeons, and cardiac imagers, to be used as a critical reference when performing these complex cases.
  • 2010 Springer
    Marc Remacle and Hans Edmund Eckel, (eds.).
  • 2008 Thieme eNeurosurgery
    [edited by] Rajiv Midha, Eric L. Zager.
    Section I: Brachial plexus injury and entrapments -- Brachial plexus avulsion--diagnostic issues / Thomas Kretschmer and Robert L. Tiel -- Upper brachial plexus injury (duchenne-erb palsy) / Andrew C. Kam and Daniel H. Kim -- Lower trunk brachial plexus palsy / Lynda J-S. Yang and John E. McGillicuddy -- Gunshot wounds to the brachial plexus / Robert J. Spinner and Robert L. Tiel -- Lateral cord injury / Robert L. Tiel and Eric L. Zager -- Medial cord injury / Robert J. Spinner and Robert L. Tiel -- Pediatric plexus injuries / James M. Drake, Patrick A. Lo, and Rajiv Midha -- Secondary reconstruction in obstetric brachial plexus injuries / Rahul K. Nath ... [et al.] -- Free functioning muscle transfers for upper extremity reconstruction of plexus palsy / Dimitri J. Anastakis and Ralph T. Manktelow -- Dorsal root entry zone: lesioning for intractable deafferentation pain / Mahmood Fazl ... [et al.] -- Neurotization in brachial plexus injury / Rahul K. Nath ... [et al.] -- Thoracic outlet syndrome / Eric L. Zager -- Nerve transfers for shoulder reanimation / Bassam M. J. Addas and Rajiv Midha -- Fascicular nerve transfers to restore elbow flexion / Ronald T. Grondin, S. Durand, and Christophe Oberlin -- Section II: Upper extremity peripheral nerve injuries and entrapments -- Spinal accessory nerve palsy / Robert L. Tiel and Eric L. Zager -- Long thoracic nerve palsy / Adrian W. Laxton and Rajiv Midha -- Suprascapular nerve palsy / Adrian W. Laxton and Rajiv Midha -- Axillary nerve injury and repair / Deb Bhowmick and Eric L. Zager -- Injury to the median nerve above the elbow / Ben Roitberg -- Anterior interosseous nerve syndrome/compression / Allen H. Maniker -- Carpal tunnel syndrome / Sheila K. Singh and Rajiv Midha -- Endoscopic carpal tunnel release / David F. Jimenez and Thomas Loftus -- Recurrent or persistent symptoms following carpal tunnel release / Brent Graham -- Digital nerve injuries / Paul Binhammer -- Ulnar nerve injury / Marie-Noëlle Hébert-Blouin and Line Jacques -- Failed ulnar nerve transposition due to unrecognized snapping of the medial triceps / Robert J. Spinner and Rajiv Midha -- Ulnar nerve entrapment at the elbow / Farhad Pirouzmand and Rajiv Midha -- Ulnar nerve compression--guyon canal / Christopher Doumas and David R. Steinberg -- Failed ulnar nerve decompression / James B. Lowe III and Susan E. Mackinnon -- Management of penetrating (lacerating) nerve injuries / Mandeep S. Tamber and Rajiv Midha -- Radial nerve injury: midhumeral level / Mubarak Al-Gahtany and Rajiv Midha -- Radial tunnel syndrome / Farhad Pirouzmand and Rajiv Midha -- Posterior interosseous nerve injury / Andrew Nataraj and Rajiv Midha -- Nerve repair with conduits / Matthew Sanborn, Eric M. Jackson, and Eric L. Zager -- Section III: Lower extremity peripheral nerve injuries and entrapments -- Ilioinguinal/iliohypogastric neuropathy / R. Graham Vanderlinden and Rajiv Midha -- Meralgia paresthetica / Douglas Cook and Rajiv Midha -- Obturator nerve injury and repair / Jason H. Huang, Robert G. Whitmore, and Eric L. Zager -- Femoral neuropathy by compression from iliacus compartment hematoma / Farhad Pirouzmand and Rajiv Midha -- Femoral nerve injuries / Allen H. Maniker -- Saphenous nerve lesions / Robert J. Spinner and Robert L. Tiel -- Sciatic nerve compression and piriformis syndrome / Robert J. Spinner and Robert L. Tiel -- Sciatic nerve injury and repair / Robert G. Whitmore, Deb Bhowmick, and Eric L. Zager -- Diagnosis and treatment of common peroneal nerve problems / Tarvinder Singh and Michel Kliot -- Peroneal nerve entrapment / Kimberly Harbaugh and Rajiv Midha -- Sural nerve injury and neuroma / Rajiv Midha -- Posterior tibial nerve injury / Justin L. Owen ... [et al.] -- Tarsal tunnel syndrome / Robert J. Spinner and Robert L. Tiel -- Morton neuroma / Neal J. Naff -- Section IV: Nerve tumors, painful nerve conditions, and miscellaneous injuries -- Schwannoma / W. Bradley Jacobs and Rajiv Midha -- Neurofibroma / W. Bradley Jacobs and Rajiv Midha -- Management of malignant peripheral nerve sheath tumors / Nabeel Al-Shafai, Rajiv Midha, and Abhijit Guha -- Brachial plexus tumor / Mubarak Al-Gahtany and Rajiv Midha -- Neurogenic sarcoma of the sciatic nerve / Charles Christian Matouk and Rajiv Miidha -- Lumbar plexus injury / Eric M. Jackson and Eric L. Zager -- Complex regional pain syndrome / Raqeeb Haque and Christopher J. Winfree -- Upper dorsal sympathectomy for hyperhidrosis / Mahmood Fazl -- Electrical stimulation for painful neuroma / Michael J. Dorsi and Allan J. Belzberg.
    Also available: Print – 2008
  • 2006
    a new edition in French by E. Nicaise including a history, a biography, and the history of the College of Surgery ; new English translation in three volumes by Leonard D. Rosenman.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Stephen F. Brockmeier, Mark D. Miller, Guillermo Arce, editors.
    This book addresses shoulder instability--all comers because the extreme variability of patients and pathology must be matched with a variety of techniques.
  • 2007 Springer
    Jörg Klekamp, Madjid Samii.
    History -- Anatomy -- Intramedullary tumors -- Extramedullary tumors -- Epidural tumors.
  • 2016 Springer
    Istvan Sziklai, editor.
    This book provides the first comprehensive overview of the various conventional and cutting-edge surgical techniques for stapes fixations. After describing the broad range of stapes fixations, it discusses the preoperative diagnostic workup, with special emphasis on the role of CT scanning. It reviews stapedectomy and stapedotomy via the classic tympanotomy approach using different stapes footplate fenestration methodologies, and describes the increasingly popular technique of middle ear endoscopy. A subsequent chapter is devoted to the important topic of robot-assisted surgery. The book then reviews the evolution of the piston prosthesis, highlighting the practical aspects of the different types of piston, their benefits, and their impact on hearing. Lasers are also discussed, and the closing chapters focus on revision surgery and consider outcome measures following stapes surgery. To better illustrate the subject matter, the book features a wealth of photographs (including more than 50 in color), as well as in-depth surgical videos.
  • Google Books
    by Bayard Holmes.
    pt. 1. Appendicitis, and other diseases about the appendix.
    Also available: Print – 1904-
  • 2013 Springer
    edited by Andrea Valeri, Carlo Bergamini, Rocco Bellantone, Celestino Pio Lombardi.
    Historical Background or De quibusdam Renum glandulis: The History of Adrenals / Donatella Lippi -- Surgical Anatomy / Celestino Pio Lombardi, Carmela De Crea, Francesco Pennestri and Marco Raffaelli -- Pathology / Gabriella Nesi and Raffaella Santi -- Diagnosis and Clinical Pictures / Gabriele Parenti and Massimo Mannelli -- Imaging / Massimo Falchini and Vittoria Rufini -- Perioperative Management / Tommaso Borracci, Luca Vitali, Lorenzo Antonuzzo, Liliana Sollazzi and Valter Perilli, et al. -- General Principles of Adrenal Surgery / Robin M. Cisco and Quan-Yang Duh -- Instrumentation and High-Technology / Francesco Corcione, Valentina Brancato and Michele Giuseppe Iovino -- Right Flank Trans-Abdominal Laparoscopic Adrenalectomy / Carlo Bergamini and Andrea Valeri -- Left Flank Trans-Abdominal Laparoscopic Adrenalectomy / Celestino Pio Lombardi, Marco Raffaelli, Carmela De Crea, Francesco Pennestri and Rocco Bellantone -- Posterior Retroperitoneoscopic Adrenalectomy / Rocco Bellantone, Marco Raffaelli, Carmela De Crea, Luigi Oragano and Celestino Pio Lombardi -- Open Adrenalectomy / Giorgio De Toma, Andrea Polistena and Giuseppe Cavallaro -- Other Techniques of Video-Assisted and Open Adrenalectomies / Rocco Bellantone, Francesco Corcione, Celestino Pio Lombardi, Marco Raffaelli and Carmela De Crea, et al. -- Outcome of Adrenal Surgery / Andrea Valeri and Carlo Bergamini.
  • v. 1-<5>, 1978-<86>
    Richard T. Shackelford.
    Status: Not Checked OutLane Catalog Record
    v.1. The Esophagus -- v. 2. Stomach and duodenum, incisions, sutures -- v. 3. Colon, anorectal tract -- v. 4. Pancreas, biliary tract, liver, spleen -- v. 5. Mesentery vasculature; hernias; small intestine; peritoneum, omentum, mesentery and retroperitoneum; surgical nutrition.
  • v. 1, 1964.
    Joaquín Barraquer, Richard C. Troutman, Joaquín Rutllán ; translation and adaptation by Richard D. Binkhorst.
    Status: Not Checked OutLane Catalog Record
    v. 1. General consideratons and intracapsular cataract extraction / by J. Barraquer, J. Rutllán ; with the cooperation of R.C. Troutman -- v. 2. Surgery of the cornea.
  • v.1-2=, 2008 ClinicalKey
    Michael R.B. Keighley, Norman S. Williams.
    This book gives comprehensive coverage of common and rare colorectal conditions, advances in the molecular biology and genetics of colorectal diseases, new laparoscopic techniques, and more. Contributions from international experts on specialized topics and 400 new illustrations ensure that the extensive text is not only current and authoritative, but easy to understand.
  • 2012 Thieme eNeurosurgery
    Bambakidis, Nicholas C.; Dickman, Curtis A.; Spetzler, Robert F.
    Section I. Foundations for Surgical Treatment -- Section II. Surgical Indications and Decision Making -- Section III. Surgical Techniques -- Section IV Fixation and Fusion Techniques.
  • 2009 Springer
    editors, J.R. Izbicki ... [et al.].
  • v. 1-2, 2007.
    [edited by] Michael J. Coughlin, Roger A. Mann, Charles L. Saltzman.
    Status: Not Checked OutLane Catalog Record
    Also available: Print – 2007
  • 2013 ClinicalKey
    [edited by] Daniel J. Berry, Jay R. Lieberman.
    Surgery of the Hip is your definitive, comprehensive reference for hip surgery, offering coverage of state-of-the-art procedures for both adults and children. Modelled after Insall & Scott Surgery of the Knee, it presents detailed guidance on the latest approaches and techniques, so you can offer your patients - both young and old - the best possible outcomes.
  • v. 1-<2>, 1984-<87>
    edited by Raymond G. Tronzo.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Philippe Neyret, Guillaume Demey, editors.
    The knee presents numerous challenges to the orthopaedic surgeon and this book presents techniques and guidance both for common surgical procedures and also for rare and difficult interventions in knee surgery. Surgical techniques and approaches in knee surgery are covered as well as postoperative complications and rehabilitation. Chapters also discuss clinical examination and preparation of the patient prior to the procedure. Surgery of the Knee is a comprehensive step-by-step guide that features more than 500 operative photographs, radiological and surgical drawings of exceptional quality. The Editors have brought together a team of experts within the field ensuring that orthopaedic surgeons in training and those wishing to improve their knowledge of the knee will find this book to be an indispensable resource for performing knee surgery.
  • v. 1-2, 2007.
    editor-in-chief, Leslie H. Blumgart ; associate editors, Jacques Belghiti ... [et al.].
    Status: Not Checked OutLane Catalog Record
    Surgical and radiologic anatomy of the liver, biliary tract, and pancreas -- Assessment of liver function in the surgical patient -- Liver blood flow: physiology, measurement, and clinical relevance -- Liver regeneration -- Liver hyperplasia, hypertrophy, and atrophy -- Bile secretion -- Biliary tract pathophysiology -- Pancreatic physiology and functional assessment -- Endotoxin and cytokines in liver and biliary tract disease -- Infections in hepatic, biliary, and pancreatic surgery -- Genetics and molecular biology of pancreatic and biliary cancers -- Molecular biology of liver carcinogenesis and hepatitis -- Liver immunology -- Clinical investigation of hepatopancreatobiliary disease -- Ultrasound of the liver, biliary tract, and pancreas -- Endoscopic ultrasound -- The role of nuclear medicine in the diagnosis and management of hepatobiliary and pancreatic diseases -- Computed tomography of the liver, biliary tract, and pancreas -- Magnetic resonance imaging of the liver, biliary tract, and pancreas -- Direct cholangiography -- Angiography -- Percutaneous biopsy -- Intraoperative diagnosis of liver, biliary, and pancreatic disease -- Preoperative and postoperative nutrition in hepatobiliary surgery -- Anesthesia and postoperative intensive care -- Perioperative critical care in hepatobiliary surgery -- Quality of life and hepatobiliary tumors -- Interventional endoscopy: technical aspects -- Radiologic hepatobiliary interventions -- Biliary-enteric anastomosis -- The natural history of gallstones and asymptomatic gallstones -- Cholecystitis -- Percutaneous approaches to the treatment of gallbladder disease -- The technique of cholecystectomy -- Laparoscopic cholecystectomy and choledocholithotomy -- Stones in the common bile duct-clinical features and open surgical approaches and techniques -- Stones in the bile duct: endoscopic and percutaneous approaches -- Cholecystolithiasis and stones in the common bile duct: which approach, when? -- Postcholecystectomy problems -- Intrahepatic stones -- Biliary atresia -- Primary sclerosing cholangitis -- Biliary stricture and fistula -- Definition and classification of pancreatitis -- Etiology, pathogenesis, and diagnostic assessment of acute pancreatitis -- Management of acute pancreatitis and complications -- Etiology, pathogenesis, and diagnosis of chronic pancreatitis -- Management of chronic pancreatitis: conservative, endoscopic, and surgical -- Tumors of the bile ducts-pathologic aspects -- Benign tumors and pseudotumors of the biliary tract -- Tumors of the gallbladder -- Intrahepatic and extrahepatic biliary cancer -- Pathology and classification of pancreatic and ampullary tumors -- Periampullary and pancreatic tumors -- Palliation of pancreatic and periampullary tumors -- Pancreaticoduodenectomy, distal pancreatectomy, segmental pancreatectomy, total pancreatectomy, and transduodenal resection of the papilla of vater -- Endocrine tumors of the pancreas: clinical picture, diagnosis, and therapy -- Cholangitis -- Pyogenic liver abscess -- Amebiasis and other parasitic infections -- Hydatid cyst of the liver -- Recurrent pyogenic cholangitis -- Bile duct cysts in adults -- Nonparasitic cystic diseases of the liver and intrahepatic biliary tree -- Surgical management of cystic disease of the liver -- Liver, biliary, and pancreatic injury -- Aneurysm and arteriovenous fistula of the liver and pancreatic vasculature -- Hemobilia and bilhemia -- Tumors of the liver-pathologic aspects -- Benign liver lesions -- Hepatocellular carcinoma -- Hepatic tumors in childhood -- Metastatic tumors -- Embolization of liver tumors -- Radiotherapy of liver tumors -- Ablation of liver tumors -- Chemotherapy of liver tumors -- Isolated hepatic perfusion for extensive liver cancers -- Intra-arterial chemotherapy for liver tumors -- Liver resection for benign disease and for liver and biliary tumors -- Vascular isolation techniques in liver resection -- Liver resection in cirrhosis of the liver -- Segment-oriented anatomic liver resections -- Portal vein embolization -- Ex vivo and in situ hypothermic hepatic resection -- Intraoperative ultrasound of the liver: techniques for liver resection and transplantation -- Cirrhosis and portal hypertension: pathologic aspects -- Management of liver failure -- Support of the failing liver -- Management of ascites in cirrhosis and portal hypertension -- Medical management of bleeding varices -- Endoscopic therapy in the management of esophageal varices: injection sclerotherapy and variceal ligation -- Portal hypertension in children -- Operative devascularization and esophageal transection -- The place of portosystemic shunting -- The place of transjugular intrahepatic portosystemic shunting -- The technique of portacaval shunt -- Distal splenorenal shunt -- The mesocaval shunt: technique -- Budd-chiari syndrome and veno-occlusive disease -- Liver and pancreatic transplantation immunobiology -- Liver transplantation: anesthesia, perioperative management, and postoperative intensive care -- Liver transplantation: indications -- Orthotopic liver transplantation -- Liver transplantation in patients with fulminant hepatitis -- Liver transplantation for tumors -- Liver transplantation in children and segmental transplantation -- Auxiliary liver transplantation -- Living donor liver transplantation -- Early and late complications of liver transplantation -- Techniques of liver replacement -- Whole organ pancreas and pancreatic islet transplantation.
  • 2016 Springer
    Christophe Hulet, Helder Pereira, Giuseppe Peretti, Matteo Denti, editors.
    This book, published in cooperation with ESSKA, provides an exhaustive review of the meniscus and its pathology, covering all aspects from the basic science of the normal meniscus to clinical and imaging diagnosis, meniscus repair and meniscectomy, outcomes and complications, postoperative management, and emerging technologies. The book opens by examining in depth aspects such as anatomy, histology, physiology, biomechanics, and physiopathology. Clear guidance is offered on arthroscopy and the classification of meniscal lesions, with consideration of the full range of meniscal pathology, including traumatic lesions, degenerative lesions, root tears, meniscal cysts, and congenital lesions. Choice of treatment in different settings is explained, and the various surgical techniques - meniscectomy, meniscal repair, and reconstruction with allografts - are described in detail with the aid of accompanying videos and with presentation of long-term results. The concluding chapter takes a look into the future of meniscus reconstruction, for example through regeneration using mesenchymal stem cells.
  • 2008 Thieme eNeurosurgery
    Daniel H. Kim [and others].
    This book is a comprehensive multidisciplinary reference for the surgical management of the most frequently encountered spine problems in the pediatric patient. An overview of developmental and clinical aspects provides essential information on biomechanics, neuroimaging, preoperative evaluation, anesthesia, and neurophysiological monitoring. The book goes on to present the surgical anatomy and various approaches to the spine and spinal cord. Chapters are grouped into easy-to-reference sections that are organized by type of problem, including congenital anomalies and developmental disorders; neoplasms; vascular malformations; inflammatory and infectious diseases; neuromuscular disease; trauma; and deformities. The book also presents special techniques for the treatment of spinal deformity, such as osteotomy, vertebrectomy, VEPTR expansion thoracoplasty, and fusionless techniques. A chapter devoted to the rehabilitation of children with spinal cord injury covers the principles and key concepts in treatment, as well as the possible secondary complications and challenges that are unique to pediatric patients.
  • 2010 ClinicalKey
    editors, June K. Robinson [and others] ; DVD editors, Ashish C. Bhatia, Thomas E. Rohrer.
    The second edition of Surgery of the Skin: Procedural Dermatology, by Dr. June K. Robinson, et al, will help you put the latest medical and cosmetic surgical procedures to work in your practice. Taking a surgeon's eye view, it discusses and illustrates new procedures such as botulinum toxin treatments and tumescent facelifts so you can provide your patients with the most effective, cutting-edge care. Videos online and on an accompanying DVD show you how to perform these in-depth surgical procedures in detail. Improve surgical outcomes and avoid pitfalls with expert, evidence-based guidance. Visualize every technique and concept with more than 1,000 full-color photographs and state-of-the-art drawings. Stay on the cutting-edge with in-depth step-by-step descriptions of the hot new procedures: Tumescent Vertical Vector Facelifts Blepharoplasty Composite Grafts Botox Treatments Soft Tissue Augmentation Management of Dysplastic Nevi & Melanoma.
  • 2015 ClinicalKey
    editors, June K. Robinson, C. William Hanke, Daniel M. Siegel, Alina Fratila ; video editors Ashish C. Bhatia, Thomas E. Rohrer.
    Anatomy for procedural dermatology / June K. Robinson -- Aseptic technique / Christie R. Travelute and Todd V. Cartee -- Anesthesia and analgesia / Teresa T. Soriano, Andrew Breithaupt, and Cameron Chesnut -- Instruments and materials / William Lear -- Patient evaluation, informed consent, preoperative assessment, and care / Mara C. Weinstein and Allison T. Vidimos -- Antibiotics / Kavita Mariwalla -- Wound healing / Sonia Lamel, Jie Li, and Robert S. Kirsner -- Wound healing and its impact on dressings and posoperative care / Yakir Levin, Katherine L. Brown, and Tania J. Phillips -- Electrosurgery / Diana Bolotin and Murad Alam -- Cryosurgery / Paola Pasquali -- Skin biopsy techniques / Andrew G. Affleck and Graham Colver -- Incision, draining, and exteriorization techniques / Masato Yasuta -- Suturing technique and other closure materials / Divya Srivastava and R. Stan Taylor -- Complex layered facial closures / Edgar F. Fincher, Hayes B. Gladstone, and Ronald L. Moy -- Hemostasis / Pedro Redondo -- Ellipse, ellipse variations, and dog-ear repairs / Allison Hanlon, Samuel E. Book, and David J. Leffell -- Random pattern cutaneous flaps / Jonathan L. Cook, Glenn D. Goldman, and Todd E. Holmes -- Axial pattern flaps / Christopher J. Miller, Tri Nguyen, and Joseph F. Sobanko -- Skin grafting / Alvaro E. Acosta ... [and 4 others] -- Acne scar revision / Greg J. Goodman -- Revision of surgical scars / Justin J. Leitenberger ... [and 3 others] -- Psychosocial issues and the cosmetic surgery patient / Dee Anna Glaser -- Evaluation and management of the aging face / Lisa M. Donofrio -- Soft-tissue augmentation / C. William Hanke ... [and 4 others] -- Chemical peels / Marina Landau and Sahar F. Ghannam -- Implants / J. Michael Carney -- Botulinum toxins / Doris Hexsel and Camile L. Hexsel -- Liposuction / C. William Hanke ... [and 4 others] -- Autologous fat transfer : evolving concepts and techniques / Kimberly J. Butterwick -- Follicular unit hair transplantation / Robert M. Bernstein -- Laser hair removal / William G. Stebbins ... [and 3 others] -- Laser treatment of tattoos and pigmented lesions / Rachel N. Pritzker ... [and 3 others] -- Photodynamic therapy / Anne Goldsberry ... [and 3 others] -- Laser-based treatment of the aging face for skin resurfacing : ablative and non-ablative lasers / Omar A. Ibrahimi, Nazanin Saedi, and Suzanne L. Kilmer -- Laser and light treatment of acquired and congenital vascular lesions / Johnny Chun Yin Chan and Henry Hin Lee Chan -- Sclerotherapy of varicose veins / Eberhard Rabe, Franz X. Breu, and Felizitas Pannier -- Endovenous thermal ablation techniques with ambulatory phlebectomy for varicose veins / Sanja Schuller-Petrović, Felizitas Pannier, and Milos̆ D. Pavlović -- Lamellar high-SMAS minimum incision face lift / Robert C. Langdon -- Vertical vector face lift with local anesthesia / Rafael A. Schulze, Brian Somoano, and Greg S. Morganroth -- Blepharoplasty and brow-lift / Alina Fratila and young Kyoon Kim -- Rejuvenation of the neck using liposuction and other techniques / William G. Stebbins, Michael S. Kaminer, and C. William Hanke -- Rejuvenation of the external female genitalia / Doris Hexsel, Sebastian Pop, and Antonio Rusciani -- Keloid management / Brian Berman, Sadegh Amini, and Hilary Baldwin -- Vitiligo surgery / Niti Khunger, Koushik Lahiri, and Venkataram Mysore -- Mohs micrographic surgery and cutaneous oncology / Hubert T. Greenway ... [and 4 others] -- Leg ulcer management / Ysabel Bello... [and 3 others] -- Nail surgery / Eckart Haneke -- Repair of the split earlobe, ear piercing, and earlobe reduction / Sirunya Silapunt and Leonard H. Goldberg -- Hidradenitis suppurativa / Virginia J. Reeder, David Ozog, and Iltefat Hamzavi -- Assessment and treatment of photoaging-related mottled pigmentation / Se Young Na and Kyoung Chan Park -- Design of the surgical suite, including large equipment, and monitoring devices / Ross M. Levy and C. William Hanke -- Dermatology office accreditation / Ross M. Levy. Emily Tierney, and C. William Hanke.
  • 2012 Springer
    Daniel Oertli, Robert Udelsman, editors.
  • 2013 ClinicalKey
    [edited by] Gregory W. Randolph ; illustrated by Robert Galla.
    Comprehensive surgical textbook on the diagnosis and management of benign and malignant disease of the thyroid and parathyroid glands.
  • 2007 Springer
    Daniel Oertli, Robert Udelsman, eds.
  • v. 1-<2>, 1979-<89>
    William W. Montgomery.
    Status: Not Checked OutLane Catalog Record
  • Lefor, Alan T.
    Status: Not Checked OutLane Catalog Record
  • 2014 CRCnetBASE
    by Jenna Morgan, Harriet Walker, Andrew Viggars.
  • 2012 AccessSurgery, Users must register and sign in to take a test
    [edited by] Lillian S. Kao, Tammy Lee.
    Pre- and postoperative care -- Critical care : anesthesiology, blood gases, and respiratory care -- Skin : wounds, infections, and burns : hands : plastic surgery -- Trauma and shock -- Transplants, immunology, and oncology -- Endocrine problems and the breast -- Gastrointestinal tract, liver, and pancreas -- Cardiothoracic problems -- Peripheral vascular problems -- Urology -- Orthopedics -- Neurosurgery -- Otolaryngology -- Pediatric surgery.
    Also available: Print – 2012
  • 2005 AccessSurgery, Users must register and sign in to take a test
    Amit D. Tevar, Rafael Azuaje, Larry Micon.
    Also available: Print – 2005
  • 2006
    editors, Michael W. Mulholland ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2011 Ovid
    editors, Michael W. Mulholland ... [et al.] ; illustrations by Holly R. Fischer.
    "The Fifth Edition of Greenfield's Surgery has been thoroughly revised, updated, and refocused to conform to changes in surgical education and practice. Reflecting the increasingly clinical emphasis of residency programs, this edition features expanded coverage of clinical material and increased use of clinical algorithms. Key Points open each chapter, and icons in the text indicate where Key Points are fully discussed. Many of the black-and-white images from the previous edition have been replaced by full-color images"--Provided by publisher.
  • 2016
    [edited by] Bruce E. Jarrell, MD, Professor, Department of Surgery, University of Maryland School of Medicine, Baltimore, Maryland, Stephen M. Kavic, MD, Associate Professor, Department of Surgery, Program Director, Residency in General Surgery, University of Maryland School of Medicine, Baltimore, Maryland.
    Status: Not Checked OutLane Catalog Record
  • 2008
    editors, Bruce E. Jarrell, R. Anthony Carabasi, III ; question editor, Eugene Kennedy.
    Status: Not Checked OutLane Catalog Record
  • 2013 ClinicalKey
    [edited by] Daniel H. Kim, Alexander R. Vaccaro, Curtis A. Dickman, Dosang Cho, Sangkook Lee, and Ilsup Kim.
    Featuring an expanded focus on in-demand endoscopic and minimally invasive spine procedures, Surgical Anatomy and Techniques to the Spine, 2nd Edition pairs new anatomic photographs and radiographic images with expertly rendered color illustrations and clear, step-by-step descriptions to help you effectively perform all of the latest and most effective spine surgery techniques. A multidisciplinary approach makes this medical reference book relevant and informative to all surgeons regardless of their specialty or level of surgical experience with the spine. Proceed with confidence. An atlas-style format featuring clear, concise, step-by-step descriptions of the anatomy and procedures along with clinical hints and pearls, tables, and management algorithms provideing swift answers and trusted guidance.Sharpen your surgical acumen with a deeper understanding of the anatomy of the surgical target and related anatomy. Comprehensive information on cervical, cervical/thoracic, thoracic/lumbar, lumbar spine, lumbar/pelvis, and other surgical locations ensures the best approaches to spine surgery and results.Understand the spine from all angles with multiple-viewpoint, full-color photographs, and illustrations.
  • 2014 Springer
    Lee J. Skandalakis, John E. Skandalakis, editors ; with contributions by Panagiotis N. Skandalakis.
    Generations of residents and general surgeons have relied upon and worn out their copies of Surgical Anatomy and Technique: A Pocket Manual. Thoroughly revised and with dozens of new illustrations, the fourth edition continues the tradition of providing a concise, accessible, and generously illustrated memory refresher for both novice and experienced clinicians. The editors have included techniques to keep the content fresh, relevant, and practice-based. Among the new topics are hand surgery, a section on central venous access, and creating an AV fistula for dialysis. All the existing chapters have been updated and expanded to reflect current surgical approaches and instrumentation. This fourth edition of Surgical Anatomy and Technique: A Pocket Manual provides the gold standard in correlating clear, practical anatomy with the correct technique in the pursuit of the best possible patient outcomes. This handy pocket manual remains a "must have" for every resident and general surgeon.
  • 2006
    Barry M. Zide ; illustrator, Craig A. Luce ; associate prosectors, Sean Boutros, Arthur Millman.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Paolo Castelnuovo, Iacopo Dallan, Manfred Tschabitscher.
    This atlas provides all the basic and advanced information required by surgeons in order to understand fully the skull base anatomy. It is organized according to anatomo-surgical pathways to the hidden areas of the skull base. These pathways are described in step-by-step fashion with the aid of a wealth of color images and illustrations. The emphasis is on endoscopic anatomy, but in order to provide a holistic perspective, informative three-dimensional reconstructions are presented alongside the endoscopic images and radiologic images are included when appropriate. In effect, windows are opened
  • 2014 AccessSurgery
    Beth Schrope.
    Physics : include medical precautions -- Instrumentation -- Advanced technologies : 3D ultrasound, contrast ultrasound -- Ultrasound of the neck, thyroid and parathyroid -- Breast ultrasound -- Abdominal ultrasound : principles (transabdominal, intraoperative, laparoscopic) -- Hepatobiliary ultrasound : include rf and other ablative therapies -- Ultrasound of pancreas -- FAST : trauma ultrasound -- Critical care ultrasound : includes chest ultrasound -- Endoscopic ultrasound : foregut including esophagus, stomach, small intestine, biliary -- Endoscopic ultrasound : hindgut including endorectal -- Genitourinary ultrasound -- Vascular ultrasound -- Ultrasound-guided regional anesthesia -- Therapeutic ultrasound -- Documentation, coding, billing, and compliance -- Credentialing.
  • 2006
    Alan E.H. Emery and Marcia L.H. Emery ; foreword by Sir John Hanson.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Robert G. Watkins, III, Robert G. Watkins, IV, editors.
  • 2015 Springer
    edited by Xiaodong Zhu.
    Cardiac Anatomy: Nomenclature and Abbreviations -- Position and Observation of the Heart and Surgical Approaches -- The Right Atrium -- The Right Ventricle -- The Coronary Artery -- The Conduction System of the Heart -- The Left Atrium -- The Left Ventricle -- The Cardiac Skeleton and the Aortic Root -- General Considerations of Cardiac Embryology -- Atrial Septal Defect and Cor Triatriatum -- Atrioventricular Septal Defect -- Ventricular Septal Defect -- Anomalous Pulmonary Venous Drainage -- Aortic Arch Coarctation and Interrupted Aortic Arch -- Congenital Anomalies of the Tricuspid Valve -- Right Ventricular Outflow Tract Obstruction -- Mitral Atresia and Hypoplastic Left Ventricle -- Single Ventricle -- Persistent Truncus Arteriosus -- Aortopulmonary Window -- Aneurism of the Sinus of Valsalva -- Tetralogy of Fallot -- Double Outlet Right Ventricle -- Complete Transposition of the Great Arteries -- Corrected Transposition of the Great Arteries -- Pulmonary Atresia -- Double-outlet of Left Ventricle.
  • 2015 Springer
    Chunlin Hou, Shimin Chang, Jian Lin, Dajiang Song.
    A brief history of perforator flaps -- Anatomy, classification and nomenclature -- Intra-operative techniques in perforator dissection -- Pedicled perforator flaps -- Combined perforator flaps -- Thinned perforator flaps -- Flow-through perforator flaps -- Lateral Arm Perforator Flap -- Medial arm perforator flap -- Radial Artery Perforator Flap -- Ulnar Artery Perforator Flap -- posterior interosseous artery perforator flap -- Posterolateral mid-forearm perforator flap -- Dorsal Metacarpal Artery Perforator Flaps -- Dorso-ulnar metacarpal perforator flap of the little finger -- Digital artery perforator flap -- Perforator flaps in the lateral thoracic region -- Deep inferior epigastric artery perforator (DIEP) flap -- Anterolateral thigh perforator flap -- Vastus medialis perforator flap -- Saphenous artery perforator flap -- Posterior thigh perforator flap -- Anterior tibial artery perforator flap -- Posterior tibial artery perforator flap -- Peroneal artery perforator flap -- Medial sural artery perforator flap -- Peroneal artery anterolateral supramalleolar flap -- Anterior supramalleolar perforator flap -- Medial supramalleolar perforator flap -- Dorsal metatarsal artery perforator flap.
  • 2015 Springer
    Andreas B. Imhoff, Matthias J. Feucht (eds.) ; translated and edited by Dr. Mohamed Aboalata.
    This atlas depicts and describes the newest arthroscopic and open techniques for dealing with sports orthopaedic injuries and problems. More than 75 surgical procedures are presented step by step with the aid of superb illustrations. Arthroscopic views, artist drawings, X-rays, and clinical and operative photographs are all included to demonstrate exactly how each procedure should be performed. Individual sections are devoted to the shoulder, elbow, pelvis/hip, knee, and ankle/foot. By offering complete illustrated guidance on the surgical management of sports-related injuries, the Surgical Atlas of Sports Orthopaedics and Sports Traumatology will prove invaluable to both novice and experienced surgeons.
  • 2012 Wiley
    edited by Forrest O. Moore, Peter M. Rhee, Samuel A. Tisherman, Gerard J. Fulda.
    Front Matter -- Supplemental Images -- Surgical Critical Care. Respiratory and Cardiovascular Physiology / Marcin A Jankowski, Frederick Giberson -- Cardiopulmonary Resuscitation, Oxygen Delivery, and Shock / Timothy J Harrison, Mark Cipolle -- Arrhythmias, Acute Coronary Syndromes, and Hypertensive Emergencies / Harrison T Pitcher, Timothy J Harrison -- Sepsis and the Inflammatory Response to Injury / Juan C Duchesne, Marquinn D Duke -- Hemodynamic and Respiratory Monitoring / Christopher S Nelson, Jeffrey P Coughenour, Stephen L Barnes -- Airway Management, Anesthesia, and Perioperative Management / Jeffrey P Coughenour, Stephen L Barnes -- Acute Respiratory Failure and Mechanical Ventilation / Lewis J Kaplan, Adrian A Maung -- Infectious Disease / Charles Kung Chao Hu, Heather Dolman, Patrick McGann -- Pharmacology and Antibiotics / Michelle Strong -- Transfusion, Hemostasis and Coagulation / Stacy Shackelford, Kenji Inaba -- Analgesia and Sedation / Juan C Duchesne, Marquinn D Duke -- Delirium, Alcohol Withdrawal, and Psychiatric Disorders / Meghan Edwards, Ali Salim -- Acid-Base, Fluid and Electrolytes / Charles Kung Chao Hu, Andre Nguyen, Nicholas Thiessen -- Metabolic Illness and Endocrinopathies / Therese M Duane, Andrew Young -- Hypothermia and Hyperthermia / Raquel M Forsythe -- Acute Kidney Injury / Terence O'keeffe -- Liver Failure / Bellal Joseph -- Nutrition / Rifat Latifi -- Neurocritical Care / Scott H Norwood, Herb A Phelan -- Venous Thromboembolism / Herb A Phelan, Scott H Norwood -- Transplantation, Immunology, and Cell Biology / Leslie Kobayashi -- Obstetric Critical Care / Gerard J Fulda, Anthony Sciscione -- Envenomations, Poisonings and Toxicology / Michelle Strong -- Common Procedures in the ICU / Adam D Fox, Daniel N Holena -- Diagnostic Imaging, Ultrasound, and Interventional Radiology / Randall S Friese, Terence O'Keeffe -- Emergency Surgery. Neurotrauma / Bellal Joseph -- Blunt and Penetrating Neck Trauma / Leslie Kobayashi -- Cardiothoracic and Thoracic Vascular Injury / Leslie Kobayashi -- Abdominal and Abdominal Vascular Injury / Leslie Kobayashi -- Orthopedic and Hand Trauma / Brett D Crist, Gregory J Della Rocca -- Peripheral Vascular Trauma / Daniel N Holena, Adam D Fox -- Urologic Trauma / Hoylan Fernandez, Scott Petersen -- Care of the Pregnant Trauma Patient / Julie L Wynne, Terence O'Keeffe -- Esophagus, Stomach, and Duodenum / Andrew Tang -- Small Intestine, Appendix, and Colorectal / Jay J Doucet, Vishal Bansal -- Gallbladder and Pancreas / Andrew Tang -- Liver and Spleen / Narong Kulvatunyou -- Incarcerated Hernias / Narong Kulvatunyou -- Soft-Tissue and Necrotizing Infection / Joseph J DuBose -- Obesity and Bariatric Surgery / Stacy A Brethauer, Carlos V R Brown -- Burns, Inhalation Injury, Electrical and Lightning Injuries / Joseph J DuBose -- Urologic and Gynecologic Surgery / Julie L Wynne -- Cardiovascular and Thoracic Surgery / Jared L Antevil, Carlos V R Brown -- Extremes of Age: Pediatric Surgery and Geriatrics / Michael C Madigan, Gary T Marshall -- Telemedicine and Surgical Technology / Rifat Latifi -- Statistics / Randall S Friese -- Ethics, End-of-Life, and Organ Retrieval / Lewis J Kaplan, Felix Lui -- Index.
  • 2011 Springer
    Rolfe Birch.
  • 2011 Springer
    Heather Fry, Roger Kneebone, editors.
  • 2013 Springer
    Iqbal Shergill, Manit Arya, Tahwinder Upile, Neehar Arya, Prokar Dasgupta, editors.
    With the introduction of new post-graduate Medical training in the UK, virtually all doctors will be exposed to some form of surgical training prior to specialization. Many of these doctors will have little exposure to surgical emergencies in medical school. Thus, they may unnecessarily refer to a senior doctor when not needed, or catastrophically neglect a patient needing urgent surgical opinion. Surgical Emergencies in Clinical Practice is a compact resource which allows any clinician, without previous surgical knowledge, to be able to make an accurate diagnosis and have a treatment plan for the whole spectrum of surgical emergencies. The essential steps of initial management of all surgical emergencies is outlined in a manner that can be used on a day-to-day basis for clinical management. Written by experts in the field, Surgical Emergencies in Clinical Practice is a valuable tool for all junior doctors and medical students in the UK, Europe, Asia and North America. It will also be of interest to nurse practitioners, general practitioners and allied health professionals managing these patients.
  • 2015 Springer
    Janice L. Pasieka, James A. Lee, editors.
    Part I. The thyroid gland -- Thyroid physiology -- Emil Theodor Kocher -- Karl von Basedow -- Jan Wolff and Israel L. Chaikoff -- Hyperthyroidism and thyroiditis -- Robert James Graves -- Henry Stanley Plummer -- Hakaru Hashimoto -- Fritz de Quervain -- George W. Crile -- Multinodular goiter -- Hugh Spear Pemberton -- Medullary thyroid carcinoma -- John Richard Farndon -- Well-differentiated thyroid cancer: papillary, follicular, and oncocytic (Hürthle) cell cancer -- Karl Hürthle -- Update of the treatment guidelines for well-differentiated thyroid cancer -- Frank Lahey -- Thomas Dunhill -- Part II. The parathyroid glands -- Primary hyperparathyroidism: diagnosis and workup -- Sir Richard Owen -- Fuller Albright -- James Bertram Collip -- Surgical management of hyperparathyroidism -- Felix Mandl -- Oliver Cope -- Parathyroidectomy: postoperative considerations/complications -- Frantis̆ek Chvostek -- Armand Trousseau -- Theodor Billroth -- Part III. The adrenal glands -- Adrenal physiology -- Thomas Addison -- Primary aldosteronism -- Jerome W. Conn -- Cushing's Syndrome -- Harvey Cushing -- J. Aidan Carney -- Pheochromocytoma and paraganglioma -- Charles Horace Mayo -- Arthur M. Shipley -- Emil Zuckerkandl -- Part IV. Neuroendocrine tumors of the pancreas -- Part IV. Neuroendocrine tumors of the pancreas -- Insulinomas -- Sir Fredrick Grant Banting -- Charles Herbert Best -- Allen Oldfather Whipple -- William J. Mayo -- Gastrinoma -- Robert Milton Zollinger -- Edwin H. Ellison -- VIPoma -- John V. Verner Jr. and Ashton B. Morrison -- Glucagonoma -- Small bowel neuroendocrine tumors -- Carcinoid syndrome -- Sigfried Oberndorfer -- Part V. Hereditary endocrine syndromes -- von Hippel-Lindau Disease -- Eugen von Hippel and Arvid Lindau -- Multiple endocrine neoplasia type 1 -- Paul Wermer -- Norman W. Thompson -- Multiple endocrine neoplasia 2 syndromes -- John H. Sipple -- Index.
  • 2015 Thieme eNeurosurgery
    [edited by] Charles J. Prestigiacomo, E. Jesus Duffis, Chirag D. Gandhi.
    "Few medical fields have enjoyed the explosive growth and continued maturation as the subspecialty of endovascular surgical neuroradiology. In pouring through the literature on all things associated with neurointerventional, I recognized the need to develop a resource that brought focus to the many devices and the techniques and procedures we do. This book does just that: It brings to sharp focus the most current, and up-to-date methods of an ever-changing specialty. It brings this information to you, through the lens of experts in their respective fields by focusing all their research into the textbook that sits before you. The "Clinical Practice" portion of this textbook integrates and translates this theory into a working paradigm that brings benefit to our patients. By focusing on technique and emphasizing complication avoidance and in those unfortunate times when the complication occurs, complication management, your patient benefits"--Provided by publisher.
  • 2010 Springer
    by Ramón Ribes, Pedro J. Aranda, John Giba.
    Methodological Approach to Surgical English -- Surgical Grammar -- Scientific Literature: Writing an Article -- Letters to Editors of Surgical Journals -- Attending an International Surgical Course -- Presenting an Oral Communication in English -- Chairing a Surgical Session -- Typical Mistakes That Surgeons Make When Speaking and Writing in English -- Latin and Greek Terminology -- Acronyms and Abbreviations in Surgery and Medicine -- Glossary of Surgical Terms -- Surgical English by Surgical Specialty -- Taking a Clinical History -- Writing a Surgical Report, Describing a Surgical Technique, Dictating a Report -- Writing a Hospital Discharge Report -- How to Write a Letter Requesting a Visit -- How to Write an International Curriculum Vitae -- Surgical Instruments -- Managing a Surgical Department -- Surgical Conversation Guide -- Conversation Survival Guide -- A Few Words About Effective Communication.
  • 2013 Springer
    John M. Hutson, Spencer W. Beasley.
  • 2009 Ovid
    Stanley Hoppenfeld, Piet deBoer, Richard Buckley ; illustrations by Hugh A. Thomas.
    The shoulder -- The humerus -- The elbow -- The forearm -- The wrist and hand -- The spine -- Pelvis and acetabulum -- The hip -- The femur -- The knee -- The tibia and fibula -- The ankle and foot -- Approaches for external fixation.
    Also available: Print – 2009
  • 2009 ClinicalKey
    Michael S. Sabel.
    Presents coverage that encompasses anatomy and physiology, and evaluation of breast symptoms...to discussions of breast cancer risk and management of breast cancer... equipping you to confidently face any challenge. Addresses hot topics including gynecomastia, neoadjuvant therapy, management of ductal carcinoma in situ, Paget's disease, risk assessment and genetic testing, breast MRI, partial breast irradiation, microarray analysis, and targeted therapies...providing you with a current perspective of this fact changing field. Begins each chapter with a bulleted list of key points, and presents crucial facts in boxes, to help facilitate review. Features abundant illustrations, photographs, and tables that clarify complex concepts. Follows a concise, logical, and consistent organization that makes the material easy to review. Whether studying for the boards or reviewing key material in preparation for a procedure.
  • 2014 Springer
    John R. Samples, Iqbal Ike K. Ahmed, editors.
    There is a revolution in new glaucoma surgical techniques. New glaucoma surgical devices are taking precedence in glaucoma surgery, with the new surgeries drastically cutting down on the chances for patient infection as well as higher success rates compared to the older types of surgery. Surgical Innovations in Glaucoma is the only book of its kind written by the top experts in the field, from inventors, clinical trial investigators, and top specialists experienced with the new devices. Written for general ophthalmologists who perform glaucoma surgery, the text walks the reader through the what, where, when, and how of the new glaucoma surgical tools, and includes supplementary online how-to videos for those interested in seeing the latest glaucoma procedures performed with these devices.
  • 2010 Springer
    edited by John M. O'Donnell, Flávio E. Nácul.
    Supplemental oxygen therapy -- Airway management in the intensive care unit -- Vascular cannulation -- Fluid resuscitation -- Vasoactive amines and inotropic agents -- Shock -- Hemodynamic monitoring -- Acid-base disorders -- Analgesia and sedation -- Neuromuscular blocking agents -- Optimization of the high-risk surgical patient -- Cardiopulmonary resuscitation -- Management of closed head injury -- Spinal cord injuries -- Ischemic stroke -- Hemorrhagic stroke -- Status epilepticus -- Critical illness plyneuorpathy and myopathy -- Management of hypertension in the perioperative period -- Postoperative myocardial infarction -- Management of postoperative arrhythmias -- Acute respiratory failure -- Mechanical ventilation -- Venous thromboembolism -- Fat emulsion syndrome -- Venous air embolism -- Sepsis -- Vascular catherter-related bloodstream infections -- Pneumonia -- Intra-abdominal sepsis -- Evaluation of the febrile patient in the ICU -- Antimicrobial use in surgical intensive care -- Coagulation abnormalities in the critically ill -- Blood products -- Hyperglycemia in the surgical intensive care unit -- Adrenal insufficiency -- Nutrition support in intensive care -- Acute kidney injury -- Renal replacement therapy -- Disorders of electrolytes -- Gastrointestinal bleeding -- Acute pancreatitis -- Trauma -- Burns -- The abdominal compartment syndrome -- Rhabdomyolysis -- Postoperative care of the cardiac surgical patient -- Postoperative care following major vascular surgery -- Postoperative care after bariatric surgery -- Care of the organ donor -- Postoperative care of the heart transplant patient -- Postoperative care of the lung-transplant patient -- Postoperative care of the liver-transplant patient -- Postoperative care of the pancreas-transplant recipient -- Management of the critically ill geriatric patient -- Alcohol withdrawal in the surgical patient: prevention and treatment -- Ethics and the end-of-life care -- Scoring systems and outcome prediction -- Improving the intensive care unit -- Continuing education in critical care medicine.
  • 2014 Springer
    P. Marco Fisichella, Carlos A. Pellegrine, Nathaniel J Soper editors.
    Surgical Management of Benign Esophageal Disorders: The ""Chicago Approach"" covers all stages of the diagnosis and treatment of the most common benign esophageal disorders in a concise and easy-to-read format. Indications, patient preparation, operative techniques, and strategies for avoiding and managing complications are included and based both on evidence-based data and the experience of the most famous esophageal surgeons in the United States and abroad. Each chapter includes a summary of the current management strategy for the disease process, and a review of current state of the art techniques provided by world leaders on esophageal disease, surgeons and gastroenterologists alike.
  • 2010 Springer
    edited by Aki Laakso, Juha Hernesniemi, Yasuhiro Yonekawa, Tetsuya Tsukahara.
    Microsurgical principles for anterior circulation aneurysms -- Treatment of ruptured cerebral aneurysms: clip and coil, not clip versus coil -- Distal anterior cerebral artery aneurysms -- Treatment of complex intracranial aneurysms of anterior circulation using multiple clips -- Overview of spontaneous cervicocephalic arterial dissection in Japan -- Incidence of intracranial arterial dissection in non-emergency outpatients complaining of headache: preliminary investigation with MRI/MRA examinations -- A study of vertebrobasilar artery dissection with subarachnoid hemorrhage -- Surgical treatment of intracranial VA dissecting aneurysm -- Management of spontaneous dissection of the cervical carotid artery -- Natural history of arteriovenous malformations: presentation, risk of hemorrhage and mortality -- Present state of microneurosurgery of cerebral arteriovenous malformations -- Management of dural arteriovenous fistulas: Helsinki and Kuopio experience -- The rationale behind "a randomized trial of unruptured brain AVMs" (ARUBA) -- Posterior circulation EC-IC bypass via supracerebellar transtentorial SCTT approach applied in a young patient with congenital multiple occlusive cerebrovascular anomalies: case report and technical note -- Superficial temporal artery-to-middle cerebral artery anastomosis with encephalo-duro-myo-synangiosis as a modified operative procedure for moyamoya disease -- Long-term results of carotid endarterectomy and carotid stenting -- Application of microscope integrated indocyanine green video-angiography during microneurosurgical treatment of intracranial aneurysms: a review -- Principles of neuroanesthesia in stroke surgery -- Prevention of symptomatic vasospasm by continuous cisternal irrigation with mock-CSF containing ascorbic acid and Mg2+.
    Also available: Print – 2010
  • 2012 Springer
    by Viktor Hras̆ka, Peter Murín.
    1. Complete Transposition of the Great Arteries 2. Corrected Transposition of the Great Arteries -- 3. Left Ventricular Outflow Tract Anomalies -- 4. Tetralogy of Fallot -- 5. Ebstein's Anomaly.
  • 2015 Springer
    Viktor Hraška, Peter Murín.
  • 2005 Springer
    edited by James C. Fang, Gregory S. Couper ; foreword by Lynne W. Stevenson.
    Recent advances in cardiac allotransplantation / John Adams Jarcho and James C. Fang -- Surgical revascularization in the management of heart failure and ischemic left ventricular dysfunction / Jeffrey J. Teuteberg and James C. Fang -- Aortic valve surgery with severe left ventricular dysfunction / Blasé A. Carabello -- Mitral valve surgery with severe left ventricular dysfunction / Vinay Badhwar and Steven F. Bolling -- Tricuspid valve surgery in right heart failure / James P. Greelish ... [et al.] -- Pacing in heart failure / Uday N. Kumar, Teresa De Marco, and Leslie A. Saxon -- Left ventricular assist devices / Paul L. DiGiorgi, Yoshifumi Naka, and Mehmet C. Oz -- Left ventricular volume reduction surgery for idiopathic dilated cardiomyopathy / Richard Lee ... [et al.] -- Surgical management of hypertrophic cardiomyopathy / William G. Williams ... [et al.] -- Dynamic cardiomyoplasty and new prosthetic LV girdling devices / Michael A. Acker -- Xenotransplantation / Joren C. Madsen and Ruediger Hoerbelt -- Left ventricular reconstruction for ischemic heart failure / Vincent Dor -- The total artificial heart in the surgical management of congestive heart failure / Jack G. Copeland, Francisco A. Arabia, and Richard G. Smith.
    Also available: Print – 2005
  • 2008 Springer
    edited by Matthias Becker, Janet Davis.
    Injectable intraocular corticosteroids / Paul A. Kurz ... [et al.] -- Intraocular corticosteroid implants / David Callanan -- Noncorticosteroid intraocular drug therapy / Francine Behar-Cohen, Jean-Louis Bourges -- Therapeutic vitrectomy for noninfectious uveitis / Kathrin Greiner, Andrew D. Dick -- Cryotherapy and laser for intermediate uveitis / Javier A. Montero, Jose M. Ruiz-Moreno -- Surgery for band keratopathy / Ruth Lapid-Gortzak ... [et al.] -- Selection of surgical technique for complicated cataract in uveitis / Mauricio Miranda, Jorge L. Alió -- Perioperative medical management / Manfred Zierhut, Peter Szurman -- Pars plana lensectomy / Emilio Dodds -- Extracellular extraction by phacoemulsification / Antoine P. Brézin, Dominique Monnet -- Selection of intraocular lenses : materials, contraindications, secondary implants / Gerd U. Auffarth -- Management of posterior synechiae, peripheral anterior synechiae, iridocorneal adhesions, and iridectomy / Yosuf El-Shabrawi -- Complications post cataract surgery in the uveitic eye / Marie-José Tassignon, Dimitrios Sakellaris -- Cataract surgery in childhood uveitis / Arnd Heiligenhaus, Carsten Heinz, Bahram Bodaghi -- Surgical management of uveitis-induced angle-closure glaucoma / Kaweh Mansouri, Tarek Shaarawy -- Surgical management of open-angle glaucoma associated with uveitis / Herbert P. Fechter, Richard K. Parrish II -- Cyclodestructive procedures / Torsten Schlote -- Macular surgery for posterior segment complications of uveitis / Janet L. Davis -- Surgical treatment of retinal vasculitis with occlusion, neovascularization or traction / Jose M. Ruiz-Moreno, Javier A. Montero -- Surgical treatment of uveitic commplications : retinal detachment / Heinrich Heimann -- Surgical management of ocular hypotony / Mark Hammer, W. Sanderson Grizzard -- Anterior chamber tap and aqueous humor analysis / Uwe Pleyer, Justus G. Garweg -- Surgery for the diagnosis of uveitis-anterior segment biopsy / Bahram Bodaghi -- Diagnostic vitrectomy / Christoph M.E. Deuter, Sabine Biester, Karl Ulrich Bartz-Schmidt -- Choroidal biopsy / Christoph M.E. Deuter, Sabine Biester, Karl Ulrich Bartz-Schmidt -- Retinal biopsy / Janet L. Davis.
  • 2015 Thieme eNeurosurgery
    [edited by] Kim J. Burchiel.
    Surgical Management of Pain, Second Edition, is a completely updated state-of-the-art reference on neurosurgical pain management. This new edition is in full color and includes the following sections: Anatomic and Physiologic Foundations for Nociceptive and Neuropathic Pain, Pain Medicine, Pain Diagnoses, Surgical Procedures for Pain, and New Directions for Pain Surgery. The chapters in the book focus on procedures that are currently performed by neurosurgeons to relieve pain. Key Features: Emphasizes best evidence treatment options free online access to videos demonstrating surgical technique.
  • 2013 ClinicalKey
    Mickey Karram, Christopher F. Maher.
    Epidemiology, risk factors, and social impact of pelvic organ prolapse / Corina Schmid and Christopher F. Maher -- Surgical anatomy of the pelvis and the anatomy of pelvic support / Mickey Karram -- Preoperative evaluation and staging of patients with pelvic organ prolapse / Mickey Karram -- Indications and techniques for vaginal hysterectomy and vaginal trachelectomy in patients with pelvic organ prolapse / Mickey Karram -- Surgical procedures to suspend a prolapsed uterus / Christopher F. Maher and Mickey Karram -- Robot-assisted laparoscopic colpo- and cervicosacropexy with the da Vinci Surgical System / Catherine A. Matthews -- Surgical management of apical vaginal prolapse / Christopher Maher and Mickey Karram -- Surgical management of anterior vaginal wall prolapse / Christopher F. Maher and Mickey Karram -- Surgical correction of posterior pelvic floor defects / Mickey Karram -- Obliterative procedures for pelvic organ prolapse / Janelle Evans and Mickey Karram -- Surgery for pelvic organ prolapse : avoiding and managing complications / Mickey Karram and Christopher F. Maher.
  • 2007
    edited by Arun Paul Amar.
    Status: Not Checked OutLane Catalog Record
    Pathogenesis of acute spinal cord injury and theoretical bases of neurological recovery / Arun Paul Amar -- Pharmacotherapy for spinal cord injury / Steven Casha, Joseph Silvaggio, R. John Hurlbert -- Prehospital and emergency department management of spinal cord injury / Stuart P. Swadron, Danny L. Chang, Brian Wilbur -- Radiographic workup of spinal cord injury / Nestor R. Gonzalez, Larry T. Khoo, Richard G. Fessler -- Controversies in surgical decompression : timing of decompressive surgery of the spinal cord / Mark S. Gerber, Volker K.H. Sonntag -- Biomechanics of spinal column failure / Eric P. Roger, G. Alexander Jones, Edward C. Benzel -- Principles of spine stabilization / G. Alexander Jones, Eric P. Roger, Edward C. Benzel -- Controversies in the management of cervical spinal cord injury / Paul G. Matz, Mark N. Hadley -- Surgical decision-making in spinal fracture dislocations / Robert G. Watkins -- Spinal cord injury in pediatric patients / Philipp R. Aldana, Douglas L. Brockmeyer -- Management of penetrating spinal cord injury / K. Anthony Kim, Arun Paul Amar, Michael L. Levy -- Traumatic vascular injury to the cervical spine / Michael L. DiLuna, Arun Paul Amar -- Intraoperative neurophysiologic monitoring during spinal surgery / Indro Chakrabarti, Jerry Larson, Gordon L. Engler, Steven L. Giannotta -- Surgery after the acute phase of traumatic spinal cord injury / Michael Y. Wang, Barth A. Green.
  • 2009 ClinicalKey
    [edited by] Thomas J. Errico, Baron S. Lonner, Andrew W. Moulton.
    A who's who in this challenging field brings you state-of-the-art approaches to the full range of surgical management options, including reconstructive procedures, for the pediatric and adult patient with spinal deformity. Experts discuss the course of treatment for patients in different age groups and take into consideration the extent of the curve at the time of diagnosis and during follow-up, the patient's stage of bone growth, the amount of pain and deformity associated with the condition, and the patient's willingness and ability to withstand surgery. Plus, a section on general information such as practical surgical anatomy, imaging, applied biomechanics, and instrumentation helps you approach each patient more effectively. The included DVD helps you perfect your technique with narrated surgical procedures. Emphasizes technical skills and surgical decision making, including pearls, pitfalls, and illustrative case studies, offering you expert advice on technically challenging surgeries. Provides the very latest information on minimally invasive endoscopic and mini-open approaches to broaden your surgical options and minimize post-operative complications. Discusses peri-operative considerations, including anesthesia, blood loss management, bone graft and fusion enhancement, neural monitoring, and complications, keeping you prepared for any event. Presents full-color line artwork of surgical procedures as well as diagnostic and clinical photographs for superb visual guidance. Offers a consistent format throughout and a full-color design for ease of reference. Website includes a video library of narrated surgical procedures to help you master your technique.
  • 2013 Springer
    Stephen Y. Nakada, Margaret S. Pearle, editors.
  • 2010 Springer
    John Rombeau, Amy Goldberg, Catherine Loveland-Jones.
    What is mentoring and who is a mentor? -- Why surgical mentoring is important and evidence that it makes a difference -- What are the qualities of an outstanding surgical mentor? -- How and where should surgical mentoring be performed? -- Mentoring women surgeons -- Mentoring international medical graduates -- How to develop faculty mentors -- How to choose a mentor -- Future directions.
  • 2014 Springer
    Kimberly A. Davis, Stanley H. Rosenbaum, editors.
    This volume is a comprehensive, state-of-the-art review for clinicians with an interest in the peri-operative nutritionalmanagement of all surgical patients. The text reviews normal physiology, the pathophysiology of starvation and surgical stressors, and focuses on appropriate nutritional repletion for various common disease states. Specifically, the text addresses the severe metabolic demands created by systemic inflammation, infection, and major insults such as trauma and burns. In addition, the book addresses the growing problem of obesity in surgical populations, including appropriate strategies directed towards the metabolic management of these patients. The text is designed for clinicians across levels of training and provides clear and concise evidence based guidelines for the metabolic management and nutritional support of the surgical patient. Written by experts in the field, Surgical Metabolism: The Metabolic Care of the Surgical Patient is a valuable resource forall cliniciansinvolved in the care of the critically ill.
  • v. 1-<5>, 1987-<92>
    P. Lasjaunias, A. Berenstein.
    Status: Not Checked OutLane Catalog Record
    v. 1. Functional anatomy of craniofacial arteries -- v. 2. Endovascular treatment of craniofacial lesions -- v. 3. Functional vascular anatomy of brain, spinal cord and spine -- v. 4. Endovascular treatment of cerebral lesions -- v. 5. Endovascular treatment of spine and spinal cord lesions.
  • 2001 Springer
    Pierre Lasjaunias, Alejandro Berenstein, K.G. ter Brugge.
    1. Clinical anatomy and variations. -- 2.1. Clinical and endovascular treatment aspects in adults ; cerebral ischemia ; vascular tumors of the head and neck ; traumatic arteriovenous fistulae ; aneurysms. -- 2.2. Clinical and endovascular treatment aspects in adults ; cerebral arteriovenous shunts ; spinal arteriovenous shunts ; spinal vascular tumors ; technical aspects of endovascular neurosurgery.
  • 2015 Springer
    Quyen D. Chu, John F. Gibbs, Gazi B. Zibari, editors.
    This volume provides a comprehensive perspective on surgical oncologic diseases that are relevant to those who have an interest in surgical oncology. Its purpose is to distill a voluminous amount of information to readers so they will have the opportunity to apply relevant information and knowledge to their particular needs. Each chapter is written by experts in their field who provide concise and in-depth information on their topic and supply references to key articles. Illustrations, diagrams, and photographs are included to assist the visual learners. Each chapter begins with bulleted key points to focus the readers on the material that will be covered and concludes with an appendix that summarizes the salient points. This unique set-up can be used as a tool to quickly review the topic at hand. The text also includes a set of short questions and answers at the end of each chapter to reinforce the salient points. Surgical Oncology: A Practical and Comprehensive Approach is a valuable resource for Medical students, surgical oncology fellows, general surgeons, and educators.
  • 2009 Springer
    edited by Ashraf Khan.
    Imaging of endocrine and neuroendocrine tumors -- Fine needle aspiration cytology of endocrine tumors -- Fine needle aspiration cytology of neuroendocrine tumors arising in non-endocrine organs -- Tumors of the pituitary gland -- Tumors of thyroid gland : non-C cell tumors -- Tumors of the thyroid gland (C-cells) -- Tumors of parathyroid gland -- Tumors of the adrenal cortex -- Tumors of the adrenal medulla and extra-adrenal paraganglia -- Endocrine tumors of the lung and upper airways -- Neuroendocrine tumors of the pancreas -- Neuroendocrine tumors of the gastrointestinal tract -- Neuroendocrine tumours of the breast -- Neuroendocrine tumors of female genital tract -- Neuroendocrine tumors of prostate, urinary bladder, and kidney -- Neuroendocrine tumors of other miscellaneous sites : thymus and skin -- Endocrine tumors and tumor-like lesions of infancy, childhood, and adolescents and inherited tumor syndromes -- Application of molecular diagnosis techniques in the diagnosis and management of endocrine tumors.
  • 2015 Springer
    Taofic Mounajjed, Vishal S. Chandan, Michael S. Torbenson, editors.
    Pseudotumors -- Benign Vascular Tumors -- Benign Mesenchymal Tumors and Miscellaneous Tumors -- Benign Hepatocellular Tumors -- Benign Biliary Tumors -- Hepatocellular Carcinoma Precursor Lesions -- Hepatocellular Carcinoma -- Fibrolamellar Carcinoma -- Cholangiocarcinoma Precancerous Lesions -- Cholangiocarcinoma -- Malignant Mesenchymal Tumors -- Hematolymphoid Lesions -- Benign Pediatric Hepatic Tumors -- Malignant Pediatric Liver Tumors -- Metastatic Tumors. .
  • 2009 Springer
    Laura W. Lamps.
  • 2012
    Recall series editor and senior editor, Lorne H. Blackbourne.
    Status: Not Checked OutLane Catalog Record
    1. Introduction -- 2. Surgical Syndromes -- 3. Surgical Most Commons -- 4. Surgical Percentages -- 5. Surgical History -- 6. Surgical Instruments -- 7. Sutures and Stitches -- 8. Surgical Knot Tying -- 9. Procedures for the Surgical Ward and Clinic -- 10. Incisions -- 11. Surgical Positions -- 12. Surgical Speak -- 13. Preoperative 101 -- 14. Surgical Operations You Should Know -- 15. Wounds -- 16. Drains and Tubes -- 17. Surgical Anatomy Pearls -- 18. Fluids and Electrolytes -- 19. Blood and Blood Products -- 20. Surgical Hemostasis -- 21. Common Surgical Medications -- 22. Complications -- 23. Common Causes of Ward Emergencies -- 24. Surgical Respiratory Care -- 25. Surgical Nutrition -- 26. Shock -- 27. Surgical Infection -- 28. Fever -- 29. Surgical Prophylaxis -- 30. Surgical Radiology -- 31. Anesthesia -- 32. Surgical Ulcers -- 33. Surgical Oncology -- 34. GI Hormones and Physiology -- 35. Acute Abdomen and Referred Pain -- 36. Hernias -- 37. Laparoscopy -- 38. Trauma -- 39. Burns -- 40. Upper GI Bleeding -- 41. Stomach -- 42. Bariatric Surgery -- 43. Ostomies -- 44. Small Intestine -- 45. Appendix -- 46. Carcinoid Tumors -- 47. Fistulas -- 48. Colon and Rectum -- 49. Anus -- 50. Lower GI Bleeding -- 51. Inflammatory Bowel Disease: Crohn's Disease and Ulcerative Colitis -- 52. Liver -- 53. Portal Hypertension -- 54. Biliary Tract -- 55. Pancreas -- 56. Breast -- 57. Endocrine -- 58. Thyroid Gland -- 59. Parathyroid -- 60. Spleen and Splenectomy -- 61. Surgically Correctable HTN -- 62. Soft Tissue Sarcomas and Lymphomas -- 63. Skin Lesions -- 64. Melanoma -- 65. Surgical Intensive Care -- 66. Vascular Surgery -- 67. Pediatric Surgery -- 68. Plastic Surgery -- 69. Hand Surgery -- 70. Otolaryngology: Head and Neck Surgery -- 71. Thoracic Surgery -- 72. Cardiovascular Surgery -- 73. Transplant Surgery -- 74. Orthopaedic Surgery -- 75. Neurosurgery -- 76. Urology.
  • 1979-
    edited by J.S.P. Lumley, J.L. Craven.
    Status: Not Checked OutLane Catalog Record
  • 19??.
    by James W. Ward.
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    Matthias Harders.
  • 2009 Springer
    Andrzej Baranski.
  • 2015 Springer
    Rakesh V. Khanna, Gennady Bratslavsky, Robert J. Stein, editors.
    This volume provides a comprehensive review and detailed description of surgical techniques for prostate cancer surgery. All aspects are covered, including surgical anatomy and methods of transrectal ultrasound guided prostate biopsies, step-by-step approach techniques for radical prostatectomy, and the latest data on outcomes. Furthermore, limitations as well as tips and tricks are detailed in addition to management of common complications. Lastly, with the increasing use of ablative therapy and brachytherapy, the mechanism of action as well as the keys to obtaining optimal outcomes are illustrated. Surgical Techniques for Prostate Cancer is a concise and valuable resource to surgeons that documents the different approaches to prostate cancer surgery.
  • 2007 Ovid
    [edited by] Neal S. Elattrache ... [et al.].
  • 2013 ClinicalKey
    edited by Brian J. Cole, Jon K. Sekiya ; associate editors, Geoffrey S. Van Thiel, Jack G. Skendzel.
    Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine presents you with a step-by-step approach on performing both open and arthroscopic surgeries for sports-related injuries. This medical reference book offers all of the expert guidance you need on everything from patient positioning and the latest orthopaedic surgery techniques, through pearls and pitfalls and post-operative care. An international group of contributors equips you with a worldwide perspective on the most recent orthopaedic advances, making Surgical Techniques of the Shoulder, Elbow, and Knee in Sports Medicine your go-to digest of today's common procedures. Ensure optimal outcomes from each shoulder, elbow and knee procedure with this orthopaedic surgery text's consistent, step-by-step approach, coupled with numerous tips, pearls, pitfalls, and images gleaned from surgeons specializing in sports injuries. Apply the latest open and arthroscopic techniques, including arthroscopic rotator cuff repair and hamstring and allograft ACL reconstruction. Access the full text and expanded surgical video collection online at Expert Consult.
  • 2013 Springer
    Jeffrey A. Morgan, Yoshifumi Naka, editors.
  • 2011 Springer
    Lorenzo Capussotti, ed. ; in collaboration with Alessandro Ferrero ...[et. al.]. ; forewords by Enrico De Antoni, Gennaro Nuzzo.
    Epidemiology and Natural History -- Diagnosis and Staging -- Evolution of Resectability Criteria -- Surgical Strategy -- Results of Surgery and Prognostic Factors -- Preoperation Chemotherapy -- Synchronous Colorectal Liver Metastases -- Therapeutic Strategies in Unresectable Colorectal Liver Metastases -- Extrahepatic Disease -- Adjuvant Chemotherapy and Follow-Up -- LiverMetSurvey Registry: the Italian Experience.
  • 2015 Springer
    Alberto Peña, Andrea Bischoff.
    Introduction -- History -- Basic Anatomy and Physiology -- Prenatal Diagnosis -- Neo-Natal Management -- Colostomy -- Imaging -- Bowel Preparation -- Perineal Fistula -- Bulbar Fistula -- Prostatic Fistula -- Bladder Neck Fistula -- No Fistula -- Minimally Invasive Approach -- Re-Operations on Male Patients -- Vestibular Fistula -- Cloacas -- Cloacal Exstrophy -- Bowel Management -- Operations to Administer Enemas -- Urologic Problems -- Hirschsprung{u2019}s Disease -- Idiopathic Constipation -- Perianal Fistula -- Posterior Sagittal Approach for Other Conditions -- Rare, Complex Defects -- Associated Defects in General -- Future, Advances -- Long Term Follow-Up -- Sacrococcygeal Teratoms -- ARM in Developing Countries -- Hemorrhoids -- Polyps -- Angiodysplasia Gastro Rectal Heterotopia Rectal Bleeding.
  • 2008 Springer
    Alfredo Guglielmi, Andrea Ruzzenente, Calogero Iacono ; in cooperation with Luigi Marchiori ... [et al.].
  • 2010 ClinicalKey
    edited by William J. Hozack, Javad Parvizi, Benjamin Bender.
    A reference that addresses the challenging issues you face in this rapidly growing segment of orthopaedic practice. Inside, youll find top surgical management strategies for all types of hip arthroplasty presented by leaders from around the world, along with discussions of possible complications, risks and benefits to specific patient populations, and more. A DVD, included with the text, presents step-by-step narrated videos of the surgeries covered in the book, enabling you to see these procedures in action.
  • 2016 Thieme-Connect
    [edited by] James Stannard, Andrew Schmidt.
    Chapter 1. The polytrauma patient -- Chapter 2. Care of the soft tissue envelope -- Chapter 3. Musculoskeletal infection associated with skeletal trauma -- Chapter 4. Acute compartment syndrome -- Chapter 5. Evolving concepts in plate fixation -- Chapter 6. Treatment strategy for nonunion -- Chapter 7. Treatment strategy for malunion -- Chapter 8. Treatment of fractures in geriatric patients -- Chapter 9. Injuries to the cervicocranium -- Chapter 10. Lower cervical spine injuries -- Chapter 11. Thoracic spine injuries -- Chapter 12. Thoracolumbar and lumbar spine injuries -- Chapter 13. Shoulder girdle injuries -- Chapter 14. Proximal humerus fractures and shoulder dislocations -- Chapter 15. Humeral shaft fractures -- Chapter 16. Distal humeral fractures -- Chapter 17. Elbow trauma -- Chapter 18. Forearm fractures -- Chapter 19. Distal radius fractures -- Chapter 20. Carpal fractures and dislocations -- Chapter 21. Hand fractures and dislocations -- Chapter 22. Pelvic ring injuries -- Chapter 23. Acetabular fractures -- Chapter 24. Hip dislocations and associated fractures of the femoral head -- Chapter 25. Femoral neck fractures -- Chapter 26. Intertrochanteric hip fractures -- Chapter 27. Subtrochanteric femur fractures -- Chapter 28. Femoral shaft fractures -- Chapter 29. Distal femur fractures -- Chapter 30. Patella fractures and injuries to the knee extensor mechanism -- Chapter 31. Knee dislocations and ligamentous injuries -- Chapter 32. Tibial plateau fractures -- Chapter 33. Tibial shaft fractures -- Chapter 34. Distal tibia fractures -- Chapter 35. Ankle fractures and dislocations -- Chapter 36. Foot fractures -- Index.
  • 2006 CRCnetBASE
    edited by Michael E. Burczynski and John C. Rockett.
  • 2014
    prepared for the Bill & Melinda Gates Foundation.
    When a malaria control program transitions to elimination, the surveillance system must change (Figure 1). These changes include rapid notification of individual cases, geo-referencing cases, and prompt response and foci investigation. Early in the development of a malaria strategy, planning should incorporate transitions that occur in the shift from control to elimination, even if elimination is a distant goal. This can help ensure that the surveillance system is flexible enough to adapt to the changes in scale and reporting time necessary when approaching elimination. Specifically, in an elimination setting, case reporting needs to shift from being periodic and aggregated at the district or provincial level to real-time reporting of individual geo-located cases. The advent of technologies that support surveillance for malaria elimination, including internet and communication technologies (ICTs), can facilitate many essential elements such as real-time reporting and case and intervention mapping. However, these technologies should only be applied where they are locally appropriate and when they can be used effectively.
  • v. 3, 1948-50.
    Bertrand, Didier; Hutchinson, G. Evelyn; Kamen, Martin David.
    Status: Not Checked OutLane Catalog Record
    1. Isotropic phenomena in biogeochemistry / M.D. Kamen -- 2. The biogeochemistry of vanadium / D. Bertrand -- 3. The biogeochemistry of vertebrate excretion / G.E. Hutchinson.
  • 2005 CRCnetBASE
    Arijit Chaudhuri, Horst Stenger.
  • 2005 Springer
    David G. Kleinbaum, Mitchel Klein.
  • Odd O. Aalen, Ørnulf Borgan, Håkon K. Gjessing.
  • 2010/2011
    Jennifer Janell Parker.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Cindy L. Schwartz, Wendy L. Hobbie, Louis S. Constine, Kathleen S. Ruccione, editors.
    Overview -- Algorithms of Late Effects by Disease -- Facilitating Assessment of Late Effects by Organ System -- Pediatric Growth and Development: Impact on Vulnerability to Normal Tissue Damage from Cancer Therapy -- Central Nervous System Effects -- Neuroendocrine Complications of Cancer Therapy -- Ocular Complications due to Cancer Treatment -- Head and Neck -- Adverse Effects of Cancer Treatment on Hearing -- The Thyroid Gland -- Cardiovascular Effects of Cancer Therapy -- Pulmonary Effects of Antineoplastic Therapy -- Late Gastrointestinal and Hepatic Effects -- The Ovary -- The Testes -- Genitourinary -- Musculoskeletal, Integument.- Breast -- Hematopoietic Stem Cell Transplantation -- Second Malignancies Following Treatment for Childhood Cancer -- Psychological Aspects of Long-Term Survivorship -- Legal Issues -- Methodological Issues in the Study of Survivors of Childhood Cancer -- Survivorship Transitions following Childhood and Adolescent Cancer -- Health Maintenance and Promotion.
  • 2011 Wiley
    edited by E. Mark Haacke, Jürgen R. Reichenbach.
  • 2013 WHO
    Crompton, D. W. T.; Daumerie, Denis; Savioli, Lorenzo.
    "The second WHO report builds on the growing sense of optimism generated by the 2012 publication of the WHO roadmap. Commitments on the part of ministries of health in endemic countries, global health initiatives, funding agencies and philanthropists have escalated since 2010, as have donations of medicines from pharmaceutical companies and the engagement of the scientific community. This report marks a new phase and assesses opportunities and obstacles in the control, elimination and eradication of several of these diseases. Unprecedented progress over the past two years has revealed unprecedented needs for refinements in control strategies, and new technical tools and protocols. The substantial increases in donations of medicines made since the previous report call for innovations that simplify and refine delivery strategies. However, some diseases, including especially deadly ones like human African trypanosomiasis and visceral Leishmaniasis, remain extremely difficult and costly to treat. The control of Buruli ulcer, Chagas disease and yaws is hampered by imperfect technical tools, although recent developments for yaws look promising. The report highlights progress against these especially challenging diseases, being made through the development of innovative and intensive management strategies. innovations in vector control deserve more attention as playing a key part in reducing transmission and disease burden, especially for dengue, Chagas disease and the Leishmaniases. Achieving universal health coverage with essential health interventions for neglected tropical diseases will be a powerful equalizer that abolishes distinctions between the rich and the poor, the young and the old, ethnic groups, and women and men."--P. 4 of cover.
    Also available: Print – 2013
  • 2011 Springer
    Cathryn H. Greenberg, Beverly S. Collins, Frank R. Thompson III, editors.
    This edited volume addresses a rising concern among natural resource scientists and management professionals about decline of the many plant and animal species associated with early-successional habitats, especially within the Central Hardwood Region of the USA. These open habitats, with herbaceous, shrub, or young forest cover, are disappearing as abandoned farmland, pastures, and cleared forest patches return to forest. There are many questions about 'why, what, where, and how' to manage for early successional habitats. In this book, expert scientists and experienced land managers synthesize knowledge and original scientific work to address critical questions sparked by the decline of early successional habitats.
  • 2007 Springer
    Piergiorgio Tozzi.
  • v.1-2=, 2012 ClinicalKey
    [edited by] Kenneth F. Swaiman [and others].
    "Swaiman's Pediatric Neurology, by Drs. Kenneth Swaiman, Stephen Ashwal, Donna Ferriero, and Nina Schor, is a trusted resource in clinical pediatric neurology with comprehensive, authoritative, and clearly-written guidance. Extensively updated to reflect advancements in the field, this fifth edition covers new imaging modalities such as pediatric neuroimaging, spinal fluid examination, neurophysiology, as well as the treatment and management of epilepsy, ADHD, infections of the nervous system, and more. The fully searchable text is now available online at www.expertconsult.com, along with downloadable images and procedural videos demonstrating intraventricular hemorrhage and white matter injury, making this an indispensable multimedia resource in pediatric neurology."--Publisher's website.
  • 2015 Springer
    Gauri Mankekar, editor.
    Anatomy of swallowing -- Physiology of swallowing -- Swallowing disorders: Clinical features & diagnosis -- Assessment of swallowing disorders -- Endoscopic management of swallowing disorders -- Radiological diagnosis in swallowing disorders -- Neurogenic dysphagia -- Medical management of swallowing disorders -- Pediatric dysphagia -- Presbyphagia.
  • 2009
    Alfred F. Tallia, editor-in-chief ; Joseph E. Scherger, Nancy W. Dickey, co-editors.
    Status: Not Checked OutLane Catalog Record
  • 2008
    R.H. Swanton, S. Banerjee.
    Status: Not Checked OutLane Catalog Record
    Cardiac symptoms and physical signs -- Congenital heart disease -- Valve disease -- The cardiomyopathies -- Coronary artery disease -- Cardiac failure -- Disturbances of cardiac rhythm : bradycardias, pacing, the ICD, biventricular pacing for heart failure -- Disturbances of cardiac rhythm : tachycardias and ablation -- Infective endocarditis -- Pericardial disease -- The heart in systemic disease -- Systemic hypertension -- Pulmonary hypertension and pulmonary embolism -- Diseases of the aorta -- Pregnancy and heart disease -- Cardiac investigations -- Echocardiography.
  • 2007 CRCnetBASE
    M. Michael Swindle ; illustrator, Richard Hughes.
    Biology, handling, husbandry, and anatomy -- Anesthesia, analgesia, and perioperative care -- Wound closure and integument -- Gastrointestinal procedures --Liver and biliary system -- Pancreas and spleen -- Urinary system and adrenal glands -- The reproductive system -- Cardiothoracic and vascular surgery/chronic intravascular catheterization -- Head and neck surgery/central nervous system -- Musculoskeletal system and orthopedic procedures -- Cardiovascular catheterization, electrophysiology, and imaging laboratory procedures -- Endoscopic, laparoscopic, and minimally invasive surgery -- Xenotransplantation and transgenic technologies --Toxicology -- Radiobiology -- Imaging techniques: CT, MRI, and PET scanning -- Ossabaw Island miniature swine: cardiometabolic syndrome assessment.
  • 2013 Springer
    Jürgen A. Richt, Richard J. Webby, editors.
    Overview of Influenza Viruses / Stephan Pleschka -- History of Swine Influenza / Stacey Schultz-Cherry, Christopher W. Olsen, Bernard C. Easterday -- Genetics, Evolution, and the Zoonotic Capacity of European Swine Influenza Viruses / Roland Zell, Christoph Scholtissek, Stephan Ludwig -- History of Swine Influenza Viruses in Asia / Huachen Zhu, Richard Webby, Tommy T. Y. Lam, David K. Smith -- Clinicopathological Features of Swine Influenza / B. H. Janke -- Diagnostics and Surveillance for Swine Influenza / Susan Detmer, Marie Gramer, Sagar Goyal, Montserrat Torremorell -- Contemporary Epidemiology of North American Lineage Triple Reassortant Influenza A Viruses in Pigs / Alessio Lorusso, Amy L. Vincent, Marie R. Gramer, Kelly M. Lager -- History and Epidemiology of Swine Influenza in Europe / Ian H. Brown -- Swine Influenza Viruses: An Asian Perspective / Young-Ki Choi, Philippe Noriel Q. Pascua, Min-Suk Song -- Swine Influenza Virus Vaccines: To Change or Not to Change--That's the Question / Kristien Van Reeth, Wenjun Ma -- Swine Influenza Virus Infections in Man / Whitney S. Krueger, Gregory C. Gray -- Interspecies Transmission of Influenza A Viruses Between Swine and Poultry / Hadi M. Yassine, Chang-Won Lee, Yehia M. Saif -- The 2009 Pandemic Influenza Virus: Where Did It Come from, Where Is It Now, and Where Is It Going? / Ian York, Ruben O. Donis -- Pandemic Influenza A H1N1 in Swine and Other Animals / Julia Keenliside -- Therapeutics Against Influenza / Elena A. Govorkova, Jonathan A. McCullers.
  • 2008
    Succinct guide to Windows users migrating to the Mac.
  • 2011
    Olivia Louise Hatton.
    Spleen tyrosine kinase (Syk) mediates a diverse array of contextually dependent cellular outcomes, from its well-characterized role in adaptive immune receptor signaling to the novel and unexpected roles in innate immune recognition, cellular adhesion, vascular development, and osteoclast maturation. Many of these novel functions involve non-canonical activation of Syk. The ultimate functional outcome of Syk signaling depends on the cellular context, the mechanism of activation, and the downstream signaling mediators utilized. Herein, we address both the mechanism of Syk activation and the downstream mediators of Syk that drive survival in Epstein-Barr virus (EBV)+ B cell lymphomas. Using B cell lines stably-transfected with a signaling inducible chimeric of the primary EBV oncogene latent membrane protein 1 (LMP1), we uncover the first evidence of non-canonical Syk activation by a viral protein. We also demonstrate that activation of both Syk and the Src family kinase Fyn are involved in the initiation of PI3K/Akt signaling by LMP1. We utilize small molecule inhibition and siRNA knockdown of Syk to establish that the regulation of apoptosis is a critical outcome of Syk signaling in EBV+ B cell lymphomas. Navigating downstream, we demonstrate that Syk promotes survival of EBV+ B cell lymphomas through a PI3K/Akt-dependent stabilization of the caspase inhibitor XIAP. Finally, we evaluate the therapeutic potential of inhibiting the Syk survival signal in EBV+ B cell lymphomas. PI3K/Akt inhibition, but not Syk inhibition, significantly reduces tumor burden in a xenogeneic model of EBV+ B cell lymphomas. Surprisingly, Syk inhibition results in tumor migration and expansion in adjacent inguinal lymph nodes. Our mechanistic characterization of Syk signaling in EBV+ B cell lymphomas reveals a novel role for Syk in both survival and migration of EBV+ B cell lymphomas. Taken together, our data also suggests that EBV drives creates a requirement for PI3K/Akt signaling for the survival of EBV+ B cell lymphomas, reminiscent of oncogene addiction, through Syk activation by LMP1 and LMP2a.
  • v. 1-4, 1954-56.
    Status: Not Checked OutLane Catalog Record
    Contents -- Course 1. Inflammatory dermatoses, rewritten and rev. by H. Montgomery and E.B. Helwig -- Course 2. Granulomatous dermatoses, rev. by Tobias R. Funt [and others] -- Course 3. Nevi and neoplasms, rewritten and rev. by David W. Kersting [and others].
  • 2008 Springer
    Joe Rosen.
  • v. 1-2, 1947-50.
    Lejwa, Arthur; Youmans, John B.
    Status: Not Checked OutLane Catalog Record
    v. 1. Nutritional anemia / edited by Arthur Lejwa -- v. 2. Plasma proteins / edited by J.B. Youmans.
  • v. 1, 3, 1957-59.
    Nimeh, William.
    Status: Not Checked OutLane Catalog Record
  • 1980/9999
    edited by A. Hamburg.
    Status: Not Checked OutLane Catalog Record
  • 2005 HighWire
    edited by Stuart M. Cobbe, John J.P. Kastelein.
    Also available: Print – 2005
  • 2002 NLM
    prepared by Marcia Zorn, Julia H. Rowland, Claudette G. Varricchio.
  • 2006
    Scott D.C. Stern, Adam S. Cifu, Diane Altkorn.
    Status: Not Checked OutLane Catalog Record
  • 2010 AccessMedicine
    Scott D.C. Stern, Adam S. Cifu, Diane Altkorn.
    The diagnostic process -- Screening & health maintenance -- Abdominal pain -- Acid-base abnormalities -- AIDS/HIV infection -- Anemia -- Back pain -- Chest pain -- Cough, fever, and respiratory infections -- Delirium and dementia -- Diabetes -- Diarrhea, Acute -- Dizziness -- Dyspnea -- Edema -- Fatigue -- Gastrointestinal bleeding -- Headache -- Hypercalcemia -- Hypertension -- Hyponatremia and hypernatremia -- Jaundice and abnormal liver enzymes -- Joint pain -- Rashes -- Renal failure, acute -- Syncope -- Weight loss, involuntary -- Wheezing and stridor.
  • 2015 AccessMedicine
    Scott D.C. Stern, Adam S. Cifu, Diane Altkorn.
    Diagnostic process -- Screening and health maintenance -- Abdominal pain -- Acid-base abnormalities -- AIDS/HIV infection -- Anemia -- Back pain -- Bleeding disorders -- Chest pain -- Cough, fever, and respiratory infections -- Delirium and dementia -- Diabetes -- Diarrhea, acute -- Dizziness -- Dyspnea -- Dysuria -- Edema -- Fatigue -- Gi bleeding -- Headache -- Hematuria -- Hypercalcemia -- Hypertension -- Hyponatremia and hypernatremia -- Hypotension -- Jaundice and abnormal liver enzymes -- Joint pain -- Kidney injury, acute -- Rash -- Sore throat -- Syncope -- Weight loss, unintentional -- Wheezing and stridor.
  • 2012 Springer
    Georges L. Kaiser.
    This concise textbook of pediatric surgery is designed to guide the reader logically from symptoms and signs to diagnosis and treatment. Each chapter is devoted to one of 35 key symptoms and signs, which are organized according to six body regions: head, neck, chest, abdomen, urogenital system, and back. In each case, a brief assessment of the presenting sign/symptom and differential diagnosis is followed by discussion of occurrence, clinical presentation and significance, diagnostic work-up, treatment, and prognosis. Informative tables, illustrations, and up-to-date references are included throughout. Readers will also have access to an e-learning tool developed in collaboration with the Institute of Medical Education, University of Bern, which highlights the characteristics of pediatric surgical disorders and their treatment and includes clinical, radiological, and intraoperative images. Every physician and surgeon, whether specialist or generalist, who cares for children will find this book to be an invaluable source of information. It is based on the extensive personal experience of the author, which includes teaching at all levels and training of pediatric surgeons.
  • 2011
    Kerri A. Spilker.
    Specification and assembly of synapses is a highly coordinated and regulated process. Knowledge of the position and connectivity of all C. elegans neurons makes it a highly useful organism for studying the underlying mechanisms that control synapse formation. Using cell-specific promoters and fluorescently-labeled synaptic vesicle proteins, we are able to monitor synapse formation in subsets of C. elegans neurons. Close observation of synapse formation in a single posterior motorneuron (DA9) led to the identification of a mutation in the alternative splicing regulator mbl-1 that changes the synaptic pattern. The cholinergic motorneuron DA9 is required for backwards locomotion and forms ~25 synapses onto both inhibitory neurons and body wall muscles in the dorsal nerve cord (DNC) of the worm. We found that the 10 most distal synapses of DA9 fail to form in mbl-1 mutants, visualized with the synaptic vesicle-associated protein RAB-3 and the active zone proteins SYD-2/liprin-[Alpha] and UNC-10/Rim. In addition, some RAB-3 mis-localizes to the dendrite of DA9 and animals have a backwards locomotion defect consistent with a loss of synapses onto dorsal body wall muscles. mbl-1 is a member of the conserved MBNL (Muscleblind like) family of CCCH zinc-finger RNA binding proteins that regulate alternative splicing of target genes by directly binding to target mRNA. In the human disease myotonic dystrophy type 1 (DM1), a progressive muscular dystrophy, sequestration of MBNL proteins in nuclear foci leads to altered splicing of downstream genes. Mis-splicing of several genes is responsible for the muscular and cardiac symptoms present in individuals with DM1. Most work on the MBNL proteins has focused on their role in muscle morphogenesis and maintenance. However, C. elegans mbl-1 is expressed in a subset of motorneurons including DA9 and is required cell autonomously in these neurons to regulate proper synapse formation. Post-synaptic and muscle markers were unaffected in mbl-1 mutant animals. Thus, our work demonstrates that mbl-1 also functions in neurons to regulate synapse formation. In a separate set of experiments, we identified a new mutation in the coding region of the touch cell-specific beta-tubulin, mec-7(wy116) that causes a defect in synapse formation in the mechanosensory neuron PLM. Previous studies have shown that mec-7 is expressed exclusively in the six touch neurons of C. elegans and is required for sensing light touch. Our mec-7 mutation leads to a loss of synaptic vesicle accumulation at PLM synaptic sites in the ventral nerve cord and synaptic vesicles are visible at ectopic locations along the lateral axon of PLM. Localization of the synaptic proteins VAMP and GIT-1 is also defective in our mutant, but neuronal morphology is wild-type. mec-7(wy116) is mildly Mec, but other alleles of mec-7 (e1506, e1527) do not phenocopy the synaptic vesicle localization defect. mec-7(wy116) is a missense mutation that alters a highly conserved Thr at position 409 to Ile. Crystal structures of tubulin indicate that this residue is on the face of tubulin that interacts with kinesin motor. Because we see synaptic vesicles along the lateral axon of PLM, we believe that kinesin-mediated vesicle transport is less efficient in mec-7(wy116) mutants.
  • 2012 Springer
    Laurence O. Trussell, Arthur N. Popper, Richard R. Fay, editors.
    1. Sound and Synapse / Laurence O. Trussell -- 2. Neuronal Response Properties and Voltage-Gated Ion Channels in the Auditory System / Nace L. Golding -- 3. The Hair Cell Synapse / Teresa Nicolson -- 4. The Endbulbs of Held / Paul B. Manis, Ruili Xie, Yong Wang, Glen S. Marrs, and George A. Spirou -- 5. The Calyx of Held Synapse / J.G.G. Borst and S.I. Rusu -- 6. Synaptic Mechanisms of Coincidence Detection / Katrina M. MacLeod and Catherine E. Carr -- 7. Inhibitory Neurons in the Auditory Brainstem / Laurence O. Trussell -- 8. Modulatory Mechanisms Controlling Auditory Processing / Raju Metherate -- 9. Mechanisms of Memory and Learning in the Auditory System / Thanos Tzounopoulos and Ricardo M. Leão.
  • 2012 Springer
    Michael R. Kreutz, Carlo Sala, editors.
    Part 1. Molecular organization of the pre- and postsynaptic scaffold -- Glutamate Receptors in Synaptic Assembly and Plasticity: Case Studies on Fly NMJs -- Scaffold Proteins at the Postsynaptic Density -- Diversity of Metabotropic Glutamate Receptor-Interacting Proteins and Pathophysiological Functions -- Regulation of the Actin Cytoskeleton in Dendritic Spines -- Synaptic Cell Adhesion Molecules -- Part 2. Molecular dynamics of the synapse -- Molecular Dynamics of the Excitatory Synapse -- The Brain's Extracellular Matrix and Its Role in Synaptic Plasticity -- Molecular Motors in Cargo Trafficking and Synapse Assembly -- Surface Traffic in Synaptic Membranes -- Synaptic Protein Degradation in Memory Reorganization -- AMPA Receptor Assembly: Atomic Determinants and Built-In Modulators -- Developmental Plasticity of the Dendritic Compartment: Focus on the Cytoskeleton -- Dendritic mRNA Targeting and Translation -- Gliotransmission and the Tripartite Synapse -- Part 3. Synapse-to-nucleus communication -- Roles of Neuronal Activity-Induced Gene Products in Hebbian and Homeostatic Synaptic Plasticity, Tagging, and Capture -- Long-Distance Signaling from Synapse to Nucleus via Protein Messengers -- Nuclear Calcium Signaling -- Integrating Neurotransmission in Striatal Medium Spiny Neurons -- Part 4.; Synaptic dysfunction and Synaptopathies -- Synaptic Dysfunction and Intellectual Disability -- Synaptic Pathology of Down Syndrome -- The Synaptic Pathology of Drug Addiction -- Synaptic Dysfunction in Schizophrenia -- Molecular and Cellular Aspects of Mental Retardation in the Fragile X Syndrome: From Gene Mutation/s to Spine Dysmorphogenesis -- Synaptic Dysfunction in Parkinson's Disease -- Synaptic Dysfunction in Alzheimer's Disease.
    Also available: Print – 2012
  • 2008 Springer
    Dennis J. Selkoe, Antoine Triller, Yves Christen (eds.).
  • 2005 Springer
    Patric K. Stanton, Clive Bramham, Helen E. Scharfman (eds.).
  • 2009 Springer
    Marzia Malcangio, editor.
  • 2010
    Kimberly A. Salvia.
    The SLC6 family of structurally related, Na+-dependent transporter proteins is responsible for presynaptic reuptake of the majority of neurotransmitters including dopamine, serotonin, norepinephrine, glycine, and GABA. Additional family members transport creatine, osmolytes, or amino acids, but several transporters remain orphans with unknown function. SLC6A17 is an orphan transporter in the SLC6 family that was first identified in the early 1990s. It is expressed exclusively in the nervous system and specifically on synaptic vesicles in glutamatergic and some GABAergic neurons. Despite extensive efforts by other research groups, no substrate or transport mechanism has been reported for SLC6A17. In this dissertation, I describe the functional characterization of SLC6A17 and discuss the potential physiological relevance of SLC6A17 as a synaptic vesicle protein. I show that endogenous and heterologous SLC6A17 localizes to vesicular populations in cultured rat hippocampal neurons and mammalian cell lines. I then use a combination of molecular manipulations to increase expression of the SLC6A17 protein at the plasma membrane and directly demonstrate that it catalyzes neutral amino acid transport. The transport characteristics of SLC6A17 resemble those of its closely related family member B0AT2 (SLC6A15). The substrate profile of the SLC6A17-dependent activity, similar to that of B0AT2, includes a sub-millimolar apparent affinity for proline and leucine and a low millimolar apparent affinity for glutamine. SLC6A17, like B0AT2, exhibits a Na+-dependent, Cl--independent transport activity that is inhibited at low pH. These similarities in substrate profile and transport mechanism suggest that SLC6A17 and B0AT2 have redundant roles, leading to our naming the SLC6A17 protein as B0AT3. Finally, I examine the pH sensitivity of B0AT3-mediated transport using live imaging techniques. My analysis suggests that B0AT3 and B0AT2 do not couple substrate movement with proton flux, supporting an uncoupled role for proton inhibition. This characterization of B0AT3 offers insights on neurotransmitter metabolism and also highlights mechanistic differences among the structurally related, but functionally divergent, SLC6 proteins.
  • 2011 Springer
    Michele Brignole, David G. Benditt ; foreword by Richard Sutton.
  • 2008 Springer
    [edited by] Laurent Papazian, Antoine Roch.
  • 2009 Springer
    [edited by] Catherine Pienkowski, Maïthé Tauber.
  • 2013 Springer
    Efim Benenson.
    Many young, inexperienced doctors, have difficultly pinpointing a diagnosis: Is it a condition to which certain diseases could belong, or a disease definable in line with certain criteria? How can I apply my basic knowledge of diseases to a real patient? How can I find the correct diagnosis for a disease that I am seeing for the very first time? The traditional diagnostic pathways conveyed by current methods of teaching, from visual identification of the disease, knowledge of diseases, understanding of symptoms or patterns to diagnosis, leave certain diagnostic questions unanswered, especially on first experience of such a clinical pattern. Syndrome-based Approach to Diagnosis: A Practical Guide offers lecturers an alternative training concept in their teaching, which provides students with a model for self-study as well as the educational tools for learning how to think in clinical terms. It also includes a basic structured program for internal medicine at a glance in the form of decision trees that cover all major internal medicine fields. This training concept is suitable as: · A self-assessment test · A study program (self study and case-based study)· A basic program covering all the major teaching objectives in a clinical discipline· A guideline and educational framework for differential diagnosis · A collection of individual therapeutic options (with presentation of clinical cases)This book is a comprehensive educational tool ideal for medical professionals and those working within medical education.
  • 2009 Springer
    [edited by] Hervé Rousseau, Jean-Philippe Verhoye et Jean-François Heautot ; [préface de Marc Laskar].
  • 2013 ClinicalKey
    Jack Kanski, Brad Bowling.
    Eyelids -- Lacrimal drainage system -- Orbit -- Dry eye -- Conjunctiva -- Cornea -- Corneal and refractive surgery -- Episclera and sclera -- Lens -- Glaucoma -- Uveitis -- Ocular tumours -- Retinal vascular disease -- Acquired macular disorders -- Hereditary fundus dystrophies -- Retinal detachment -- Vitreous opacities -- Strabismus -- Neuro-ophthalmology -- Ocular side effects of systemic medication -- Trauma.
  • 2014 Springer
    Abdelhamid H. Elgazzar.
    Improved understanding of the pathophysiologic changes in different diseases, including the molecular mechanisms of pathologic conditions such as tumors, has enhanced our ability to apply non-invasive techniques to investigate these diseases and permitted earlier detection and better management. It has also expanded the use of functional imaging, including molecular imaging. This synopsis is a companion to The Pathophysiologic Basis of Nuclear Medicine and arose from the recognition that there is a need for a compact, readable account of this complex and important subject. The companion book concisely describes relevant anatomic and physiologic considerations for each organ system and the pathophysiologic features of different relevant diseases, and relates them to the scintigraphy of each system. It thereby provides an informative synopsis of the pathophysiologic basis of nuclear medicine and molecular imaging. The volume will serve as a quick reference that will help the reader to understand different scintigraphic patterns and to select appropriate treatment modalities based on functional imaging. It will prove useful to undergraduates and postgraduates as well as to practitioners in clinical and research fields.
  • 2008
    Howard S. An, Kern Singh.
    Status: Not Checked OutLane Catalog Record
    Anatomy and surgical approaches -- History and physical examination -- Spinal imaging and diagnostic tests -- Biomechanics of the spine and spinal instrumentation -- Physiology of bone grafts and bone graft substitutes -- Evaluation and management of spinal cord injury-- Spinal rehabilitation and disability evaluation -- Cervical spine trauma -- Thoracolumbar spine fractures -- Biomechanical aspects of intervertebral disc degeneration -- Degenerative cervical spine disorders: surgical and nonsurgical treatment -- Degenerative thoracic spine conditions -- Lumbar disc disease: pathogenesis and treatment options -- Lumbar spinal stenosis -- Surgical management of axial back pain -- Lumbar spondylolisthesis -- Scoliosis -- Kyphosic spinal deformities in children and adults -- Spinal tumors -- Spinal infections -- Rheumatoid arthritis -- Seronegative spondyloarthropathies -- Pediatric cervical spine disorders.
  • 2016 Thieme-Connect
    Howard S. An, Kern Singh.
    Anatomy and surgical approaches -- History and physical examination -- Radiographic anatomy -- Spinal imaging and diagnostic tests -- Intraoperative neuromonitoring -- Biomechanics of the spine and spinal instrumentation -- Physiology of bone healing and fusion -- Bone grafts, substitutes, and biologics -- Evaluation and management of spinal cord injury -- Cervical spine trauma -- Thoracolumbar spine fractures -- Spinal rehabilitation and disability evaluation -- Biochemical aspects of intervertebral disk degeneration -- Degenerative cervical spine disorders -- Degenerative thoracic spine conditions -- Lumbar disk disease: pathogenesis and treatment options -- Surgical management of lumbar degenerative disk disease -- Lumbar spinal stenosis -- Lumbar spondylolisthesis -- Adult spinal deformity -- Pediatric spinal deformity -- Pediatric cervical spine disorders -- Spinal tumors -- Spinal infections -- Rheumatoid arthritis -- Seronegative spondyloarthropathies.
  • v. 1-, 2006- Atypon
  • 2006 ScienceDirect
    R.S. Vardanyan, V.J. Hruby.
  • 2013 Springer Protocols
    edited by Karen M. Polizzi, Cleo Kontoravdi.
    In Synthetic Biology , expert researchers in the field provide the latest developments in molecular biology techniques used in Synthetic Biology. Focusing on computational tools that will aid in systematising the design and construction of parts and systems. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Synthetic Biology seeks to aid scientists in the further study of developing new biological components and systems.
  • 2008
    Gal Almogy.
    Status: Not Checked OutLane Catalog Record
  • 2009 Springer
    Markus Schmidt ... [et al.], editors.
    Introduction / Markus Schmidt -- That Was the Synthetic Biology That Was / Luis Campos -- An Introduction to Synthetic Biology / Carolyn M.C. Lam, Miguel Godinho and Vítor A.P. Martins dos Santos -- Computational Design in Synthetic Biology / Maria Suarez, Guillermo Rodrigo, Javier Carrera and Alfonso Jaramillo -- The Ethics of Synthetic Biology: Outlining the Agenda / Anna Deplazes, Agomoni Ganguli-Mitra and Nikola Biller-Andorno -- Do I Understand What I Can Create? Biosafety Issues in Synthetic Biology / Markus Schmidt -- Security Issues Related to Synthetic Biology Between Threat Perceptions and Governance Options / Alexander Kelle -- The Intellectual Commons and Property in Synthetic Biology / Kenneth A. Oye and Rachel Wellhausen -- Governing Synthetic Biology: Processes and Outcomes / Joyce Tait -- Synthetic Biology and the Role of Civil Society Organizations Shaping the Agenda and Arena of the Public Debate / Dirk Stemerding, Huib de Vriend, Bart Walhout and Rinie van Est -- Summary and Conclusions / Alexander Kelle.
  • 2013 ScienceDirect
    edited by Huimin Zhao.
    Synthetic Biology provides a framework to examine key enabling components in the emerging area of synthetic biology. Chapters contributed by leaders in the field address tools and methodologies developed for engineering biological systems at many levels, including molecular, pathway, network, whole cell, and multi-cell levels. The book highlights exciting practical applications of synthetic biology such as microbial production of biofuels and drugs, artificial cells, synthetic viruses, and artificial photosynthesis. The roles of computers and computational design are discussed, as well as future prospects in the field, including cell-free synthetic biology and engineering synthetic ecosystems. Synthetic biology is the design and construction of new biological entities, such as enzymes, genetic circuits, and cells, or the redesign of existing biological systems. It builds on the advances in molecular, cell, and systems biology and seeks to transform biology in the same way that synthesis transformed chemistry and integrated circuit design transformed computing. The element that distinguishes synthetic biology from traditional molecular and cellular biology is the focus on the design and construction of core components that can be modeled, understood, and tuned to meet specific performance criteria and the assembly of these smaller parts and devices into larger integrated systems that solve specific biotechnology problems. Includes contributions from leaders in the field presents examples of ambitious synthetic biology efforts including creation of artificial cells from scratch, cell-free synthesis of chemicals, fuels, and proteins, engineering of artificial photosynthesis for biofuels production, and creation of unnatural living organisms. Describes the latest state-of-the-art tools developed for low-cost synthesis of ever-increasing sizes of DNA and efficient modification of proteins, pathways, and genomesHighlights key technologies for analyzing biological systems at the genomic, proteomic, and metabolomic levels which are especially valuable in pathway, whole cell, and multi-cell applications. Details mathematical modeling tools and computational tools which can dramatically increase the speed of the design process as well as reduce the cost of development.
  • 2011 ScienceDirect
    edited by Christopher Voigt.
    Also available: Print – 2011
  • 2011 ScienceDirect
    edited by Christopher Voigt.
    Also available: Print – 2011
  • 2014 CRCnetBASE
    Bor-Sen Chen, and Yu-Chao Wang.
    Mathematical models and design specifications in synthetic gene networks -- Robust synthetic biology designs based on system dynamic models -- Robust synthetic biology designs based on network evolutionary methods -- Construction of promoter and promoter-RBS libraries for synthesis of gene networks -- Robust synthetic gene network designs based on library-search method -- Robust design of synthetic biological filter and transistor based on promoter-RBS libraries -- Communication and synchronization of a population of coupled synthetic gene networks.
  • 2012 Springer Protocols
    edited by Wilfried Weger, Martin Fussenegger.
    In silico implementation of synthetic gene networks -- Standardization in synthetic biology -- Robust optimal design of synthetic biological networks -- Predicting synthetic gene networks -- Reprogramming a GFP reporter gene subjects it to complex lentiviral gene regulation -- A high-throughput microfluidic method for generating and characterizing transcription factor mutant libraries -- Identifying and optimizing intracellular protein-protein interactions using bacterial genetic selection -- Zinc-finger nucleases-based genome engineering to generate isogenic human cell lines -- RNA-based networks: Using RNA aptamers and ribozymes as synthetic genetic devices -- MicroRNA circuits for transcriptional logic -- Light-regulated gene expression in yeast -- Light-controlled gene switches in mammalian cells -- Expressed protein modifications: Making synthetic proteins -- Using transcription machinery engineering to elicit complex cellular phenotypes -- Streamlining of a pseudomonas putida genome using a combinatorial deletion method based on minitransposon insertion and the flp-FRT recombination system -- Transposon-based and plasmid-based genetic tools for editing genomes of gram-negative bacteria -- Synthetic networks: Oscillators and toggle switches for escherichia coli -- Studying microbial communities in biofilms -- Quantitative analysis of the spatiotemporal dynamics of a synthetic predator-prey ecosystem -- Drosophila s2 schneider cells: A useful tool for rebuilding and redesigning approaches in synthetic biology -- Synthetic gene networks in plant systems -- Design and construction of synthetic gene networks in mammalian cells -- Synthetic gene networks as blueprint for smart hydrogels.
  • 2013 Springer Protocols
    edited by Peter M. Rabinovich.
    Cell engineering with synthetic messenger RNA / Peter M. Rabinovich and Sherman M. Weissman -- In vitro transcription of long RNA containing modified nucleosides / Norbert Pardi [and others] -- HPLC purification of in vitro transcribed long RNA / Drew Weissman [and others] -- Synthetic mRNAs with superior translation and stability properties / Ewa Grudzien-Nogalska [and others] -- Nonviral, cationic lipid-mediated delivery of mRNA / James G. Hecker -- Light-induced mRNA transfection / Sigurd Leinæs Bøe and Eivind Hovig -- Engineering B cells with mRNA / Jaewoo Lee, David Boczkowski, and Smita Nair -- Programming human dendritic cells with mRNA / Jaewoo Lee, David Boczkowski, and Smita Nair -- Large volume flow electroporation of mRNA : clinical scale process / Linhong Li [and others] -- Retrovirus-based mRNA transfer for transient cell manipulation / Melanie Galla, Axel Schambach, and Christopher Baum -- mRNA delivery to human dendritic cells by recombinant yeast and activation of antigen-specific memory T cells / Frank Breinig, Tanja Breinig, and Manfred J. Schmitt -- Nonviral RNA transfection to transiently modify T cells with chimeric antigen receptors for adoptive therapy / Tobias Riet [and others] -- Natural killer cell reprogramming with chimeric immune receptors / Noriko Shimasaki and Dario Campana -- Reprogramming to pluripotency and differentiation of cells with synthetic mRNA / Peizhe Wang and Jie Na -- Antitumor vaccination with synthetic mRNA : strategies for in vitro and in vivo preclinical studies / Mustafa Diken [and others] -- Mannosylated and histidylated LPR technology for vaccination with tumor antigen mRNA / Chantal Pichon and Patrick Midoux -- Analysis of survivin-specific T cells in breast cancer patients using human DCs engineered with survivin mRNA / Ozcan Met and Inge Marie Svane -- mRNA electroporation as a tool for immunomonitoring / Nathalie Cools [and others] -- mRNA PCR-based epitope chase method / Jean-Daniel Doucet, Dominique Gauchat, and Rejean Lapointe.
  • 2005 CRCnetBASE
    edited by Levon Michael Khachigian.
  • 2008 Springer
    Kailash C. Khulbe, C.Y. Feng, Takeshi Matsuura.
  • 2014 Springer
    edited by Graham Flint, Clare Rusbridge.
    Syringomelia is a relatively rare clinical entity in which fluid-filled cavities develop within the spinal cord. Although modern imaging technologies usually permit an accurate diagnosis at an early stage, syringomyelia remains an enigmatic condition that continues to fascinate neurosurgeons, neurologists and other specialists. This reference monograph provides an up-to-date account of the present stateofunderstanding of syringomyelia and related disorders.The editors aim to document the best clinical practice in diagnosis and treatment and to provide clear guidance on how to reduce the incidence of severe outcomes. New challenges are addressed, including the appropriate management of the increasing number of apparently idiopathic syrinx cavities that are detected. In addition, controversies in current practice and directions for future research are fully discussed. Syringomelia will be an invaluable source of information for experts in the field, specialists in various related disciplines and other interested health care professionals.
  • 2009
    Heather L. McCullough.
    Status: Not Checked OutLane Catalog Record
  • 2009
    Virginia C. Karlsson.
    Status: Not Checked OutLane Catalog Record
    The systematic approach to strabismus -- The four-part exam -- Approaching children and infants -- Approaching adults -- Extraocular muscles : anatomy and function -- Binocularity -- Differential diagnosis : ins, outs, ups, and downs -- Syndromes with ocular manifestations -- Nonsurgical treatment of strabismus.
  • 2009
    David Gillis Hendrickson.
    In the last decade, RNA interference (RNAi), the process by which small RNAs direct the post-transcriptional silencing of cognate mRNA transcripts has revolutionized longstanding paradigms about RNA function. In addition, researchers have harnessed this pathway for experimentally induced gene silencing in what is arguably one of the most important technological advances in modern biology. That disruption of the RNAi pathway results in aberrant development, cancer, and embryonic death suggesting that RNAi is an integral component of eukaryotic gene expression programming. Although RNAi is a vast and diverse pathway with marked distinctions between species, the basic organization has been established largely from work carried out in worms, flies, humans and mice. Double stranded RNA (dsRNA) inputs are "diced" by the class III ribonuclease Dicer into small dsRNA intermediates of ~21-22nt in length which are transferred to the RNA induced silencing complex (RISC) wherein the guide strand is selected and bound to an Argonaute (Ago) family protein. Target mRNAs are then recruited to RISC through Watson-Crick base pairing to the guide strand. Silencing of target transcripts can be directed by Ago mediated cleavage, or through Ago mediated recruitment of factors that induce translational inhibition and mRNA degradation. MicroRNAs (miRNAs) are the most common class of endogenous small silencing RNAs. Despite these advances, many of molecular details of RISC mediated gene silencing are poorly understood as current models are based on only a few miRNA:mRNA target pairs. Here, we present a method for systematic identification of specific miRNA targets. We demonstrate that immuno-affinity purification (IP) of Argonaute proteins is a viable method for isolating RISC associated miRNAs and mRNAs for identification using DNA microarrays. The strong enrichment of mRNAs with binding sites to the experimentally introduced miR-1 and miR-124 in Ago IPs from human embryonic kidney 293T cells (HEK293T) validates the utility of this method. Furthermore, mRNAs classified as targets of miR-1 and miR-124 using this approach behave like bona fide targets in that they exhibit significant down-regulation at the mRNA level. To learn about the steps in gene expression regulated by miRNAs, we simultaneously measured miR-124 mediated changes in Ago enrichment, mRNA abundance, and ribosome occupancy and ribosome density for ~8,000 genes. The translational parameters were used to estimate apparent changes in translational rate and were collected using standard polysome profiling in tandem with DNA microarrays and a novel gradient encoding scheme. We found that for the majority of the miR-124 targets, changes in mRNA concentration and apparent translation rate are concordant and that ~75% of the estimated change in protein levels could be accounted for by changes in mRNA abundance. Our data is most consistent with models of miRNA inhibition of translation initiation. To rule out miRNA mediated repressive mechanisms that would not be visible to our translational profiling (concordant reductions in translational initiation and elongation, co-translational proteolysis) we tested the protein levels for 13 targets by Western blot and found that our estimated changes in protein were nearly identical to the actual changes for 12/13 of the proteins measured. In addition, we observed a large dynamic range for miR-124 mediated down-regulation of mRNA abundance and apparent translation rate, and estimated protein abundance demonstrating the versatility of miRNA mediated regulation. The concordance between miR-124 specific changes in mRNA level and translation supports a model wherein these two regulatory outcomes are functionally linked in a sequential process or regulated by the same cis factors. We have also sought to learn about the RNAi pathway from a Dicer-centric perspective. We generated a library of Dicer truncations to test the contribution of Dicer's conserved protein domains to in vitro dicing reactions to learn about potentially interesting in vivo function as well as for increasing the efficacy of in vitro dicing as a gene silencing tool. We found that the domain of unknown function 283 (DUF283) may be important for proper spacing in dicing reactions and is part of Dicer's "molecular ruler". In addition we found that the ATPase/Helicase domains may inhibit Dicer activity and are dispensable for in vitro dicing, but may play a role in non-canonical substrate recognition.
  • 2012 AccessMedicine
    George V. Lawry.
    A step-by-step learning text and atlas designed to teach essential and foundational skills of musculoskeletal physical assessment. Comprised of a 3-part learning system: 1. Screening Musculoskeletal Examination (SMSE): rapid assessment of structure and function 2. General Musculoskeletal Examination (GMSE): comprehensive assessment of joint inflammation and arthritis 3. Regional Musculoskeletal Examination (RMSE): focused assessments of structure and function combined with special testing of the shoulder, knee, and neck and low back.
    Also available: Print – 2012
  • 2015 Springer
    Stefania Boccia, Paolo Villari, Walter Ricciardi, editors.
    "This wide-ranging study reviews the state of public health worldwide and presents informed recommendations for real-world solutions. Identifying the most urgent challenges in the field, from better understanding the causes of acute diseases and chronic conditions to reducing health inequities, it reports on cost-effective, science-based, ethically sound interventions. Chapters demonstrate bedrock skills essential to developing best practices, including flexible thinking for entrenched problems, conducting health impact assessments, and working with decision-makers. From these current findings come long-term practice and policy goals for preventing disease, promoting health, and improving quality of life, both locally and globally."--Publisher's website.
  • 2015 Springer
    Neus Evans, Michelle Lasen, Komla Tsey.
    Rapid urbanisation, inequalities in income and service levels within and between communities, and population and economic decline are challenging the viability of rural communities worldwide. Achieving healthy and viable rural communities in the face of rapidly changing social, ecological and economic conditions is a declared global priority. As a result, governments all over the world, in both developed and developing countries, are now prioritizing rural and regional development through policies and programs aimed at enhancing the livelihoods of people living in rural regions. In recognition of the important roles that research can play in rural development, a range of systematic literature reviews have rightly examined key priorities in rural development including education, gender, economic development (especially agriculture), and health and nutrition (see Department for International Development [DFID], 2011). However, none of these works has systematically examined the extent to which rural development as a field of research is progressing towards facilitating sustainable change. This book evaluates trends in rural development research across the five continental regions of the world. Specifically, it assesses the total publication output relating to rural development, the types of publications, their quality and impact over the last three decades. Additionally, it evaluates the continental origins of the publications as well as the extent to which such publications engage with issues of sustainability. The aim is to determine whether the rural development field is growing in a manner that reflects research and policy priorities and broader social trends such as sustainability. Development policy makers, practitioners, those teaching research methods and systematic literature reviews to undergraduate and graduate students, and researchers in general will find the book both topical and highly relevant.
  • 2014 Ovid
    Heidi D. Nelson.
    1. Systematic reviews -- 2. Defining the topic and scope and developing research questions, analytic frameworks, and protocols -- 3. Building the systematic review team, engaging stakeholders, and managing the project -- 4. Determining inclusion and exclusion criteria for studies -- 5. Conducting searches for relevant studies -- 6. Selecting studies for inclusion -- 7. Extracting data from studies and constructing evidence tables -- 8. Assessing quality and applicability of studies -- 9. Qualitative analysis -- 10. Quantitative analysis -- 11. Assessing and rating the strength of the body of evidence -- 12. Preparing and disseminating the report.
  • 2015 Springer
    Rolando Cimaz, editor.
    "This comprehensive volume provides current state of the art of the use of corticosteroids in the pediatric patient. It consists of 14 chapters written by leading authors from different countries. The first chapters cover historical notes, general concepts on treatment with corticosteroids with regard to indications and side effects, and basic pharmacologic properties of these compounds. The rest of the book is devoted to the specific use of steroids in the different pediatric subspecialties. Despite advances with newer effective immunosuppressive and anti-inflammatory drugs, corticosteroids still remain the mainstay of therapy for many disorders. Leading authors in their field have summarized these concepts to provide an authoritative, comprehensive guide to help clinicians safely and effectively use corticosteroids in their pediatric patients."--Publisher's website.
  • 1993-
    editors, Pierre J. Vinken, George W. Bruyn, Harold L. Klawans ; volume editors, C. G. Goetz, C. M. Tanner, and M. J. Aminoff.
  • 2014 Springer Protocols
    edited by Paul Eggleton, Frank J. Ward.
    Pathology of Systemic Lupus Erythematosus - The Challenges Ahead -- The Lupus Biomarker Odyssey: One Experience -- Detection of Anti Nuclear Antibodies in SLE -- Tests for Circulating Immune Complexes -- Methods for Measuring Antibody Dependent Cell-Mediated Cytotoxicity in vitro -- Recombinant Antibody Microarray for Profiling the Serum Proteome of SLE -- Bi-functional Antibody Fragment-based Fusion Proteins for the Targeted Elimination of Pathogenic T-cell Subsets -- TLC Immunostaining for Detection of ?Anti-Phospholipid? Antibodies -- Induced Murine Models of Systemic Lupus Erythematosus -- Measuring Interferon Alpha and other Cytokines in SLE -- Detection of SLE antigens in Neutrophils Extracellular Traps (NETs) -- Detection and Characterization of Autoantibodies Against Modified Self-proteins in SLE Sera after Exposure to Reactive Oxygen and Nitrogen Species -- Generation of Self-peptides to Treat Systemic Lupus Erythematosus -- Measurement of Malondialdehyde, Glutathione and Glutathione Peroxidase in SLE Patients -- Evaluating a Particular Circulating MicroRNA Species from an SLE Patient using Stem Loop qRT-PCR -- Microarray Technology for Analysis of MicroRNA Expression in Renal Biopsies of Lupus Nephritis Patients. Laboratory Tests for the Antiphospholipid Syndrome -- Isolation, Polarisation and Expansion of CD4+ T Helper Cell Lines and Clones using Magnetic Beads -- Meta-analysis as a Diagnostic Tool for Predicting Disease Onset and/or Activity in Systemic Lupus Erythematosus.
  • 2011 ClinicalKey
    editor, Robert G. Lahita ; associate editors, George Tsokos, Jill P. Buyon, Takao Koike.
    Systemic lupus erythematosus (SLE), commonly called lupus, is a chronic autoimmune disease which can involve every organ system of the human body. In lupus, the body's immune system, which normally functions to protect against foreign invaders, becomes hyperactive, forming antibodies that attack normal tissues and organs, including the skin, joints, kidneys, brain, heart, lungs, and blood. Lupus is characterized by periods of illness, called flares, and periods of wellness, or remission. Lupus is the prototypic autoimmune disease and SLE examines the entire field of autoimmunity by looking at lupus. There is no other book in the field which carefully covers scientific research, clinical findings, organ system involvement and treatment between its two covers. The fifth edition continues to serve as a vital translational reference for specialists in the diagnosis and management of patients with SLE, and as a key a tool for the measurement of clinical activity for pharmaceutical development and basic research of the disease and a reference work for hospital libraries.
  • v. 1-6, 1976-80.
    by thirty-eight authors, [C.W.M. Adams ... [et al.] ; editor, W. St. C. Symmers].
    Status: Not Checked OutLane Catalog Record
    v. 1. Cardiovascular system, Respiratory system -- v. 2. Blood and bone marrow, Lymphoreticular system, Thymus gland -- v. 3. Alimentary system -- v. 4. Urinary system, Reproductive system, Breast, Endocrine system -- v. 5. Nervous system, Muscle, Bone, Joints -- v. 6. Skin, Eyes, Ears.
  • 1986-
    edited by I. Friedmann ; contributors, M.H. Bennett, J. Piris ; general editor, W.St.C. Symmers.
  • 2012 Springer
    Lotfi Hendaoui, Anthony W. Stanson, M. Habib Bouhaouala, Francis Joffre, editors ; foreword by Albert L. Baert.
  • 2007 CRCnetBASE
    Gregory Bedny, Waldemar Karwowski.
  • 2014 Springer
    Andrew Emili, Jack Greenblatt, Shoshana Wodak, editors.
    Epigenetic modifications underlie all aspects of human physiology, including stem cell renewal, formation of cell types and tissues. They also underlie environmental impacts on human health, including aging and diseases like cancer. Consequently, cracking the epigenetic "code" is considered a key challenge in biomedical research. Chromatin structure and function are modified by protein complexes, causing genes to be turned on or off and controlling other aspects of DNA function. Yet while there has been explosive growth in the epigenetics field, human chromatin-modifying machines have only recently started to be characterized. To meet this challenge, our book explores complementary experimental tracks, pursued by expert international research groups, aimed at the physical and functional characterization of the diverse repertoire of chromatin protein machines - namely, the "readers, writers and erasers" of epigenomic marks. These studies include the identification of RNA molecules and drugs that interact selectively with components of the chromatin machinery. What makes this book distinctive is its emphasis on the systematic exploration of chromatin protein complexes in the context of human development and disease networks.
  • 2014 Springer
    Natalia Maltsev, Andrey Rzhetsky, T. Conrad Gilliam, editors.
    "Understanding the genetic architecture underlying complex multigene disorders is one of the major goals of human genetics in the upcoming decades. Advances in whole genome sequencing and the success of high throughput functional genomics allow supplementing conventional reductionist biology with systems-level approaches to human heredity and health as systems of interacting genetic, epigenetic, and environmental factors. This integrative approach holds the promise of unveiling yet unexplored levels of molecular organization and biological complexity. It may also hold the key to deciphering the multigene patterns of disease inheritance"--Publisher's description.
    Also available: Print – 2014
  • Gil Alterovitz, Marco F. Ramoni, editors.
    Molecular and Cellular Biology: An Engineering Perspective. Analysis: Signal Processing. Analysis: Control and Systems. Analysis: Probabilistic Data Networks and Communications. Design: Synthetic Biology. Integration: Reverse Engineering from Biology.
  • 2007 Springer
    edited by Helena I. Boshoff and Clifton E. Barry III.
  • 2013 Springer
    Michael G. Katze, editor.
    First, systems biology is an inter-disciplinary approach, requiring the combined talents of biologists, mathematicians, and computer scientists. Second, systems biology is holistic, with the goal of obtaining a comprehensive understanding of the workings of biological systems. This is achieved through the acquisition of massive amounts of data by high-throughput technologies-oligonucleotide microarrays, mass spectrometry, and next-generation sequencing-and the analysis of this data through sophisticated mathematical algorithms.
  • 2007 Springer
    edited by Mohamed Al-Rubeai and Martin Fussenegger.
  • 2007 Springer
    P. Bringmann, E.C. Butcher, G. Parry, B. Weiss, editors.
  • 2005 Springer
    Lilia Alberghina, Hans V. Westerhoff (eds.).
    Also available: Print – 2005
  • 2007 CRCnetBASE
    edited by Andrzej K. Konopka.
    Basic concepts of systems biology / Andrzej K. Konopka -- Understanding through modeling : a historical perspective and review of biochemical systems theory as a powerful tool for systems biology / Eberhard O. Voit and John H. Schwacke -- Thermostatics : a poster child of systems thinking / Peter Salamon, Anna Salamon, and Andrzej K. Konopka -- Friesian epistemology / Kelley L. Ross -- Reconsidering the notion of the organic / Robert E. Ulanowicz -- The metaphor of "chaos" / Wlodzimierz Klonowksi -- Biological complexity : an engineering perspective / Stephen W. Kercel -- The von Neumann's self-replicator and a critique of its misconceptions / Stephen W. Kercel -- The mathematical structure of thermodynamics / Peter Salamon ... [et al.].
  • 2009 Springer
    Sang Yup Lee, editor.
  • 2015 Springer
    Seth J. Corey, Marek Kimmel, Joshua N. Leonard, editors.
    The blood system is multi-scale, from the organism to the organs to cells to intracellular signaling pathways to macromolecule interactions. Blood consists of circulating cells, cellular fragments (platelets and microparticles), and plasma macromolecules. Blood cells and their fragments result from a highly-ordered process, hematopoiesis. Definitive hematopoiesis occurs in the bone marrow, where pluripotential stem cells give rise to multiple lineages of highly specialized cells. Highly-productive and continuously regenerative, hematopoiesis requires a microenvironment of mesenchymal cells and blood vessels. A Systems Biology Approach to Blood is divided into three main sections: basic components, physiological processes, and clinical applications. Using blood as a window, one can study health and disease through this unique tool box with reactive biological fluids that mirrors the prevailing hemodynamics of the vessel walls and the various blood cell types. Many blood diseases, rare and common can and have been exploited using systems biology approaches with successful results and therefore ideal models for systems medicine. More importantly, hematopoiesis offers one of the best studied systems with insight into stem cell biology, cellular interaction, development; linage programing and reprograming that are every day influenced by the most mature and understood regulatory networks.
    Also available: Print – 2014
  • 2014 Springer
    Matej Orešič, Antonio Vidal-Puig, editors.
  • 2014 Springer
    Leszek Konieczny, Irena Roterman-Konieczna, Paweł Spólnik.
    The objective of this book is to present the strategies employed by living organisms on a molecular level and to help understand the basics of Systems Biology. Its content is organized in a way to meet the exponential growth in the volume of biological knowledge, and the need for a multidisciplinary approach in the practice of teaching modern biology. For this reason, the whole material is divided into five chapters, each devoted to a fundamental concept: Structure-Function, Energy, Information, Regulation and Interrelationships. The book describes generic mechanisms which occur in biology and promotes a simulation-based approach to the subject of Systems Biology. The use of basic knowledge as the background for presenting biological problems obligates the teachers to deal with generalized phenomena comprising the ever increasing volume of teaching materials.
  • 2012 Springer
    Aleš Prokop, Seth Michelson.
  • 2012 Springer
    Asfar S. Azmi, editor.
    Part I. Systems biology in cancer -- Part II. Systems approaches to understand cancer progression -- Part III. Systems and network biology in decoding miRNA complexity -- Part IV. Network modeling in cancer drug discovery and clinical trials.
  • v. 1-, 2010- Springer
    Choi, Sangdun.
  • 2015 Springer Protocols
    edited by Juan I. Castrillo, Stephen G. Oliver.
    Alzheimer's as a systems-level disease involving the interplay of multiple cellular networks / Juan I. Castrillo and Stephen G. Oliver -- Application of systems theory in longitudinal studies on the origin and progression of Alzheimer's disease / Simone Lista [and others] -- APP proteolytic system and its interactions with dynamic networks in Alzheimer's disease / Sally Hunter, Steven Martin, and Carol Brayne -- Effects of mild and severe oxidative stress on BACE1 expression and APP amyloidogenic processing / Jiangli Tan, Qiao-Xin Li, and Genevieve Evin -- Advanced assay monitoring APP-carboxyl-terminal fragments as markers of APP processing in Alzheimer disease mouse models / Ana García-Osta and Mar Cuadrado-Tejedor -- Optical super-resolution imaging of [beta]-amyloid aggregation in vitro and in vivo : method and techniques / Dorothea Pinotsi, Gabriele S. Kaminski Schierle, and Clemens F. Kaminski -- Protocols for monitoring the development of Tau pathology in Alzheimer's disease / Alberto Rábano [and others] -- LC3-II tagging and western blotting for monitoring autophagic activity in mammalian cells / Anne Streeter, Fiona M. Menzies, and David C. Rubinsztein -- Advanced mitochondrial respiration assay for evaluation of mitochondrial dysfunction in Alzheimer's disease / Amandine Grimm, Karen Schmitt, and Anne Eckert -- Analysis of microglial proliferation in Alzheimer's disease / Diego Gomez-Nicola and V. Hugh Perry -- Yeast as a model for Alzheimer's disease : latest studies and advanced strategies / Mathias Verduyckt [and others] -- Yeast as a model for studies on A[beta] aggregation toxicity in Alzheimer's disease, autophagic responses, and drug screening / Afsaneh Porzoor and Ian Macreadie -- Drosophila melanogaster as a model for studies on the early stages of Alzheimer's disease / Jung Yeon Lim, Stanislav Ott, and Damian C. Crowther -- Chronic mild stress assay leading to early onset and propagation of Alzheimer's disease phenotype in mouse models / Mar Cuadrado-Tejedor and Ana García-Osta -- Gene expression studies on human trisomy 21 iPSCs and neurons : towards mechanisms underlying Down's syndrome and early Alzheimer's disease-like pathologies / Jason P. Weick, Huining Kang, George F. Bonadurer III, and Anita Bhattacharyya -- Cortical differentiation of human pluripotent cells for in vitro modeling of Alzheimer's disease / Nathalie G. Saurat, Frederick J. Livesey, and Steven Moore -- Next generation sequencing in Alzheimer's disease / Lars Bertram -- Pooled-DNA sequencing for elucidating new genomic risk factors, rare variants underlying Alzheimer's disease / Sheng Chih Jin, Bruno A. Benitez, Yuetiva Deming, and Carlos Cruchaga -- New genome-wide methods for elucidation of candidate copy number variations (CNVs) contributing to Alzheimer's disease heritability / Kinga Szigeti -- RNA-sequencing to elucidate early patterns of dysregulation underlying the onset of Alzheimer's disease / Bei Jun Chen, James D. Mills, Caroline Janitz, and Michael Janitz -- Systems biology approaches to the study of biological networks underlying Alzheimer's disease : role of miRNAs / Wera Roth, David Hecker, and Eugenio Fava -- Emerging role of metalloproteomics in Alzheimer's disease research / Dominic J. Hare, Alan Rembach, and Blaine R. Roberts -- Redox proteomics in human biofluids : sample preparation, separation and immunochemical tagging for analysis of protein oxidation / Fabio Di Domenico, Marzia Perluigi, and D. Allan Butterfield -- Advanced shotgun lipidomics for characterization of altered lipid patterns in neurodegenerative diseases and brain injury / Miao Wang and Xianlin Han -- AlzPathway, an updated map of curated signaling pathways : towards deciphering Alzheimer's disease pathogenesis / Soichi Ogishima [and others] -- Computational network biology approach to uncover novel genes related to Alzheimer's disease / Andreas Zanzoni -- Network approaches to the understanding of Alzheimer's disease : from model organisms to humans / Justin Yerbury, Dan Bean, and Giorgio Favrin -- Characterization of genetic networks associated with Alzheimer's disease / Bin Zhang, Linh Tran, Valur Emilsson, and Jun Zhu -- Network-based analysis for uncovering mechanisms underlying Alzheimer's disease / Masataka Kikuchi [and others] -- SDREM method for reconstructing signaling and regulatory response networks : applications for studying disease progression / Anthony Gitter and Ziv Bar-Joseph -- Advanced neuroimaging methods towards characterization of early stages of Alzheimer's disease / Jorge Sepulcre and Joseph C. Masdeu -- Plasma proteomics biomarkers in Alzheimer's disease : latest advances and challenges / Robert Perneczky and Liang-Hao Guo -- Practical guide for exploring opportunities of repurposing drugs for CNS diseases in systems biology / Hongkang Mei [and others].
  • 2013 Springer
    Inna N. Lavrik, editor.
    Modeling formalisms in systems biology of apoptosis / Stefan Kallenberger and Stefan Legewie -- Systems biology of death receptor-induced apoptosis / Kolja Schleich and Inna N. Lavrik -- Systematic complexity reduction of signaling models and application to a CD95 signaling model for apoptosis / Dennis Rickert, Nicolai Fricker, Inna N. Lavrik, and Fabian J. Theis -- Systems biology of the mitochondrial apoptosis pathway / Jochen H.M. Prehn, Heinrich J. Huber, and Carla O'Connor -- Systems biology of cell death in hepatocytes / Rebekka Schlatter, Kathrin Schmich, Christoph Borner, Michael Ederer, and Irmgard Merfort -- Understanding different types of cell death using systems biology / Laurence Calzone, Andrei Zinovyev, and Boris Zhivotovsky -- Modeling single cells in systems biology / Nicolai Fricker and Inna N. Lavrik -- Cytokine-cytokine cross talk and cell-death decisions / Christopher D. Deppmann and Kevin A. Janes -- Genetic and genomic dissection of apoptosis signaling / Christina Falschlehner and Michael Boutros.
  • 2012 ScienceDirect
    edited by Colin Harwood and Anil Wipat.
    Focusing on the systems biology of bacteria and microorganisms, the 39th volume of Methods in Microbiology investigates the interface between molecular biology, bioinformatics, and modelling and predicting behavior. This cutting-edge research area is of extreme importance to the field and is developing quickly. Written by research experts in the field. Provides a guide for lab scientists, researchers, and students. Focuses on up-to-date research methods.
  • 2014 Springer
    Miguel A. Aon, Valdur Saks, Uwe Schlattner, editors.
    From Physiology, Genomes, Systems and Self-Organization to Systems Biology : The Historical Roots of a Twenty-First Century Approach to Complexity / M.A. Aon, D. Lloyd, and V. Saks -- Complex Systems Biology of Networks : The Riddle and the Challenge / Miguel A. Aon -- Systems Biology of Signaling Networks -- The Control Analysis of Signal Transduction / Hans V. Westerhoff, Samrina Rehman, Fred C. Boogerd, Nilgun Yilmaz, and Malkhey Verma -- MicroRNAs and Robustness in Biological Regulatory Networks. A Generic Approach with Applications at Different Levels : Physiologic, Metabolic and Genetic / Jacques Demongeot, Olivier Cohen, and Alexandra Henrion-Caude -- Dynamics of Mitochondrial Redox and Energy Networks : Insights from an Experimental-Computational Synergy / Sonia Cortassa and Miguel A. Aon -- Adenylate Kinase Isoform Network : A Major Hub in Cell Energetics and Metabolic Signaling / Song Zhang, Emirhan Nemutlu, Andre Terzic, and Petras Dzeja -- Systems Biology of Cellular Structures and Fluxes -- Moonlighting Function of the Tubulin Cytoskeleton : Macromolecular Architectures in the Cytoplasm / Judit Ovádi and Vic Norris -- Metabolic Dissipative Structures / Ildefonso Mtz. de la Fuente -- Systems Biology Approaches to Cancer Energy Metabolism / Alvaro Marín-Hernández, Sayra Y. López-Ramírez, Juan Carlos Gallardo-Pérez, Sara Rodríguez-Enríquez, Rafael Morena-Sánchez, and Emma Saavedra -- Systems Biology of Organ Function -- Network Dynamics in Cardiac Electrophysiology / Zhilin Qu -- Systems Level Regulation of Cardiac Energy Fluxes via Metabolic Cycles : Role of Creatine, Phosphotransfer Pathways, and AMPK Signaling / Valdur Saks, Uwe Schlattner, Malgorzata Tokarska-Schlattner, Theo Wallimann, Rafaela Bagur, Sarah Zorman, Martin Pelosse, Pierre Dos Santos, Franc̦ois Boucher, Tuuli Kaambre, and Rita Guzun -- Systems Biology of Microorganisms -- Temporal Partitioning of the Yeast Cellular Network / Douglas B. Murray, Cornelia Amariei, Kalesh Sasidharan, Rainer Machné, Miguel A. Aon, and David Lloyd -- Systems Biology and Metabolic Engineering in Bacteria / Johannes Geiselmann.
  • 2014 Springer
    Gene Yeo, editor.
    1. Evolutionary conservation and expression of human RNA-binding proteins and their role in human genetic disease -- 2. The functions and regulatory principles of mRNA intracellular trafficking -- 3. RNA-binding proteins in regulation of alternative cleavage and polyadenylation -- 4. Functional analysis of long noncoding RNAs in development and disease -- 5. Piwi proteins and piRNAs step onto the systems biology stage -- 6. Manipulation of RNA using engineered proteins with customized specificity -- 7. Genetic variation and RNA binding proteins: tools and techniques to detect functional polymorphisms -- 8. Genome-wide activities of RNA-binding proteins that regulate cellular changes in the epithelial to mesenchymal transition (EMT) -- 9. Antisense oligonucleotide-based therapies for diseases caused by pre-mRNA processing defects -- 10. RNA-binding protein misregulation in microsatellite expansion disorders -- 11. RNA-binding proteins in heart development -- 12. Identification of miRNAs and their targets in C. elegans -- 13. Splicing code modeling -- Index.
    Also available: Print – 2014
  • 2013 Springer
    Johnjoe McFadden, Dany J.V. Beste, Andrzej M. Kierzek, editors.
    Tuberculosis remains one of the world's biggest killers responsible for more than a million deaths each year. New drugs and new vaccines are urgently needed to tackle the disease. This book describes the application of this century's first new science, systems biology, to the study of tuberculosis. After introducing the basic principles of systems biology, successive chapters describe how systems-based approaches provide new insights into gene regulation, metabolism, protein-protein interaction, host-pathogen interactions, the immune response, persistence, drug treatment and diagnosis of tuberculosis. This book will be an invaluable aid to anyone interested in exploring how the latest science is helping us to understand this ancient disease.
  • 2013 Springer
    Heiko Enderling, Nava Almog, Lynn Hlatky, editors.
    Also available: Print – 2013
  • 2007 MyiLibrary
    edited by Isidore Rigoutsos and Gregory Stephanopoulos.
  • 2010 ScienceDirect
    edited by Edison T. Liu and Douglas A. Lauffenburger.
  • 2012 Springer
    Christoph Wittmann, Sang Yup Lee, editors.
    Preface / Christoph Wittmann and Sang Yup Lee -- 1. Genome-scale network modeling / Sang Yup Lee, Seung Bum Sohn, Hyun Uk Kim, Jong Myoung Park, Tae Yong Kim, Jeffrey D. Orth, and Bernhard Ø. Palsson -- 2. Kinetic modeling of metabolic networks / Daniel C. Zielinski and Bernhard Ø. Palsson -- 3. Design of superior cell factories based on systems wide omics analysis / Katsunori Yoshikawa, Chikara Furusawa, Takashi Hirasawa, and Hiroshi Shimizu -- 4. Technologies for bio-systems engineering / Sonja Billerbeck, Sven Dietz, Gaspar Morgado, and Sven Panke -- 5. Systems metabolic engineering of Escherichia coli for chemicals, materials, biofuels, and pharmaceuticals / Dokyun Na, Jin Hwan Park, Yu-Sin Jang, Jeong Wook Lee, and Sang Yup Lee -- 6. Systems metabolic engineering of Corynebacterium glutamicum for biobased production of chemicals, materials and fuels / Judith Becker, Stefanie Kind, and Christoph Wittmann -- 7. Towards a synthetic biology of the stress-response and the tolerance phenotype: systems understanding and engineering of the Clostridium acetobutylicum stress-response and tolerance to toxic metabolites / Eleftherios T. Papoutsakis and Keith V. Alsaker -- 8. Model-based design of superior cell factory: an illustrative example of Penicillium chrysogenum / I. Emrah Nikerel, Peter J.T. Verheijen, Walter M. van Gulik, and Joseph J. Heijnen -- 9. Bridging omics technologies with synthetic biology in yeast industrial biotechnology / António Roldão, Il-Kwon Kim, and Jens Nielsen -- 10. Design of superior cell factories for a sustainable biorefinery by synthetic bioengineering / Tomohisa Hasunuma, Fumio Matsuda, and Akihiko Kondo -- 11. Systems-level analysis of cancer metabolism / Paulo A. Gameiro, Christian M. Metallo, and Gregory Stephanopoulos.
  • 2013 Springer Protocols
    edited by Hal S. Alper.
    Genome-scale model management and comparison / Stephan Pabinger and Zlatko Trajanoski -- Automated genome annotation and metabolic model reconstruction in the SEED and model SEED / Scott Devoid [and others] -- Metabolic model refinement using phenotypic microarray data / Pratish Gawand [and others] -- Linking genome-scale metabolic modeling and genome annotation / Edik M. Blais, Arvind K. Chavali, and Jason A. Papin -- Resolving cell composition through simple measurements, genome-scale modeling, and a genetic algorithm / Ryan S. Senger and Hadi Nazem-Bokaee -- Guide to integrating transcriptional regulatory and metabolic networks using PROM (probabilistic regulation of metabolism) / Evangelos Simeonidis, Sriram Chandrasekaran, and Nathan D. Price -- Kinetic modeling of metabolic pathways : application to serine biosynthesis / Kieran Smallbone and Natalie J. Stanford -- Computational tools for guided discovery and engineering of metabolic pathways / Matthew Moura, Linda Broadbelt, and Keith Tyo -- Retrosynthetic design of heterologous pathways / Pablo Carbonell, Anne-Gaelle Planson, and Jean-Loup Faulon -- Customized optimization of metabolic pathways by combinatorial transcriptional engineering / Yongbo Yuan, Jing Du, and Huimin Zhao -- Adaptive laboratory evolution for strain engineering / James Winkler, Luis H. Reyes, and Katy C. Kao -- Trackable multiplex recombineering for gene-trait mapping in E. coli / Thomas J. Mansell, Joseph R. Warner, and Ryan T. Gill -- Identification of mutations in evolved bacterial genomes / Liam Royce [and others] -- Discovery of posttranscriptional regulatory RNAs using next generation sequencing technologies / Grant Gelderman and Lydia M. Contreras -- 13C-based metabolic flux analysis : fundamentals and practice / Tae Hoon Yang -- Nuclear magnetic resonance methods for metabolic fluxomics / Shilpa Nargund [and others] -- Using multiple tracers for 13C metabolic flux analysis / Maciek R. Antoniewicz -- Isotopically nonstationary 13C metabolic flux analysis / Lara J. Jazmin and Jamey D. Young -- Sample preparation and biostatistics for integrated genomics approaches / Hein Stam [and others] -- Targeted metabolic engineering guided by computational analysis of single-nucleotide polymorphisms (SNPs) / D.B.R.K. Gupta Udatha [and others] -- Linking RNA measurements and proteomics with genome-scale models / Christopher M. Gowen and Stephen S. Fong -- Comparative transcriptome analysis for metabolic engineering / Shuobo Shi, Tao Chen, and Xueming Zhao -- Merging multiple omics datasets in silico : statistical analyses and data interpretation / Kazuharu Arakawa and Masaru Tomita.
  • 2011 Springer
    Kenji Kansaku, Leonardo G. Cohen, editors.
    Part I. Brain-Machine Interfaces and Neurorehabilitation Brain-Computer Interfaces in the Rehabilitation of Stroke and Neurotrauma / Surjo R. Soekadar, Niels Birbaumer, and Leonardo G. Cohen -- Brain-Machine Interfaces for Persons with Disabilities / Kenji Kansaku -- Brain-Machine Interfaces Based on Computational Model / Yasuharu Koike, Hiroyuki Kambara, Natsue Yoshimura, and Duk Shin -- Improvement of Spastic Stroke Hemiparesis Using rTMS Combined with Motor Training / Satoko Koganemaru, Tatsuya Mima, Hidenao Fukuyama, and Kazuhisa Domen -- Molecular and Electrophysiological Approaches for Functional Recovery in Patients with Injured Spinal Cord / Toru Ogata, Noritaka Kawashima, Kimitaka Nakazawa, and Masami Akai -- Part II. Augmenting Cognition -- Prism Adaptation and the Rehabilitation of Spatial Neglect / Sophie Jacquin-Ciourtois, Jacinta O'Shea, Jacques Luauté, Laure Pisella, Alessandro Farné, Patrice Revol, Gilles Rode, and Yves Rossetti -- Toward a Cure Based on a Better Understanding of Autism Spectrum Disorder / Shigeru Kitazawa and Tamami Nakano -- Exceeding the Limits: Behavioral Enhancement Via External Influence / Katsumi Watanabe -- Neural Correlates of Reasoning by Exclusion / Akitoshi Ogawa.
  • by Gail Hodge.
  • 2011 Springer
    Donald K. Fromme.
  • 2009
    [edited by Don de Savigny and Taghreed Adam].
    Status: Not Checked OutLane Catalog Record
  • 2012
    Jia-Yun Chen.
    Differentiation versus proliferation decisions have to be tightly regulated since excessive proliferation or premature differentiation can be harmful to multicellular organisms. While both growth factor-activated PI3K/AKT and Ras/ERK signaling have been shown to play crucial roles in proliferation and differentiation, it is not understood if and how these two pathways work in concert to make balanced cell fate decisions. Here, in the first part of my thesis, using single cell analysis of nerve growth factor (NGF)-induced PC12 cell differentiation, we uncovered a two dimensional (2D) phospho-ERK (pERK), phospho-AKT (pAKT) signaling code that reveals a sharp boundary that specifies cell fate. The boundary position remains invariant when different stimuli are used or upstream signaling components perturbed. In addition, we found that a marked cell-to-cell signal variation broadens the signal distribution in the pERK and pAKT plane so that the population spreads across the boundary, inhabiting both the differentiation and proliferation regions and creating two subpopulations with defined outcomes. We further screened for regulators of cell fate with a rat signaling siRNA library, and identified the RasGAP Rasa2, which actively maintains the stochastically distributed pERK-pAKT signals close to the decision boundary. We show that Rasa2 RasGAP activity is regulated by PI3K and acts as a negative feedback regulator between the Ras and PI3K pathways. Finally, we demonstrate that Rasa2-dependent positioning at the boundary allows for uniform NGF stimulation to create a subpopulation of cells that differentiates with each cycle of proliferation. Thus, by linking a complex signaling system to a simpler intermediate response map, cells gain unique integration and control capabilities to balance cell number expansion with differentiation. In the second part of the thesis, we further studied how proliferation decisions are made in G1 phase of the cell cycle. We focused on the role of dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1a), the strongest hit identified from our siRNA screen which markedly promotes proliferation when knocked down. Combining long-term time-lapse microscopy, single-cell image analysis and biochemical experiments, we found that Dyrk1a exhibits a sensitive dosage-dependent effect on G1 duration through direct regulation of cyclin D1stability. Knockdown of Dyrk1a greatly increases cyclin D1 and shortens G1 duration. Surprisingly, it also creates a second distinct population with cells exiting the cell cycle. This bifurcation is due to the upregulation of p21 at high cyclin D1 levels. This led to an unexpected finding that there exists a two-dimensional p21-cyclin D1 response map that encodes G1 cell fates. We further show that different doses of Dyrk1a function to shift the relative balance between cyclin D1 and p21, thereby allowing an sensitive control of G1 cell fates. The Dyrk1a gene is localized at chromosome 21, which has three copies in patients with Down syndrome (DS). Therefore, we extended our observation to the study of the cell cycle in DS-derived fibroblasts. We showed that with a 1.5-fold increase in Dyrk1a, DS cells have extended G1 duration, reduced proliferation and lower cyclin D1-to-p21 ratio relative to normal cells. Strikingly, all of these phenotypes could be partially rescued by inhibiting Dyrk1a kinase activity or knockdown of Dyrk1a. Our observation likely explains the reduced risk of solid tumors in adults with Down syndrome and provides potential therapeutic insight in terms of treating the DS-associated neurogenesis and proliferation defects during development. Altogether, this thesis has established two important concepts for cell fate decisions. First, single-cell fate could be more accurately predicted by considering two dimensional inputs, emphasizing the existence of hubs that function as information integration points where critical decisions are made. Second, natural variations could be advantageous in maintaining population balance and provide cells with decision plasticity. We envision that these findings will point out new directions for future studies on cell fate decisions and lead to a greater understanding of stem cell regulation and cancer development.

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