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  • Drug Interactions and Pharmacogenetics -- Breast Cancer -- Lung Cancer -- Gastrointestinal Cancer: Selection of Clinically Relevant Drug-Induced Toxicities Encountered in Gastrointestinal Cancer Treatment -- Gynecologic Cancer -- Genitourinary Cancer -- Central Nervous System -- Bone Marrow Toxicity: Red Blood Cells -- Bone Marrow Toxicity: White Blood Cells -- Dermatologic Side Effects of Systemic Anticancer Therapy -- Myeloid Malignancies -- Lymphoma -- Multiple Myeloma -- Preservation of Fertility in the Cancer Patient -- Cardiotoxicity -- Toxicity of Bone-Targeted Agents in Malignancy -- State of the Art of Antiemetic Therapy -- Side Effects of Nociceptive Cancer Pain Treatments in Adults -- Totally Implanted Access Ports: Indications and Prevention of Complications.
  • Also available: Print – 2007
  • Also available: Print – 2015
    Signal and image analysis techniques are becoming more widely used in biomedical and life science applications. With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to some of the applications. It can be used by those both at graduate and specialist levels.
  • Part I. Image Reconstruction and Restoration -- 1. Introduction to Image Reconstruction / Zhi-Pei Liang, Jim Ji, and E. Mark Haacke -- 2. Wavelet-Based Multiresolution Local Tomography / E. Rashid-Farrokhi and K.J.R. Liu -- 3. The Point Spread Function of Convolution Regridding Reconstruction / Gordon E. Sarty -- 4. Mapping Motion and Strain with MRI / Yudong Zhu -- 5. Rotational Motion Artifact Correction Based on Fuzzy Projection onto Convex Sets / Chaminda Weerasinghe, Lilian Ji, and Hong Yan -- 6. Tagged MR Cardiac Imaging / Nikolaos V Tsekos and Amir A. Amini -- 7. Functional MR Image Visualization and Signal Processing Methods / Alex R. Wade, Brian A. Wandell, and Thomas P. Burg --Part II. Image Segmentation and Analysis -- 8. Multiscale Segmentation of Volumetric MR Brain Images / Wiro J. Niessen, Koen L. Vincken, Joachim Weickert, and Max A. Viergever -- 9. A Precise Segmentation of the Cerebral Cortex from 3-D MRI Using a Cellular Model and Homotopic Deformations / Yann Cointepas, Isabelle Bloch, and Line Garnero -- 10. Feature Space Analysis of MRI / Hamid Soltanian-Zadeh -- 11. Geometric Approaches for Segmentation and Signal Detection in Functional MRI Analysis / Guillermo Sapiro -- 12. MR Image Segmentation and Analysis Based on Neural Networks / Javad Alirezaie and M.E. Jernigan -- 13. Stochastic Model Based Image Analysis / Yue Wang and Tiilay Adal -- 14. Functional MR Image Analysis -- Shang-Hong Lai and Ming Fang -- 15. Tagged MR Image Analysis / Amir A. Amini and Yasheng Chen -- Part III. Spectroscopic Signal Processing -- 16. Time-Domain Spectroscopic Quantitation / Leentje Vanhamme, Sabine Van Huffel, and Paul Van Hecke -- 17. Multidimensional NMR Spectroscopic Signal Processing / Guang Zhu and Yingbo Hua -- 18. Advanced Methods in Spectroscopic Imaging / Keith A. Wear -- 19. Characterization of Brain Tissue from MR Spectra for Tumor Discrimination / Paulo J.G. Lisboa, Wael El-Deredy, Y.Y. Barbara Lee, Yangxin Huang, Angelica R. Corona Herandez, Peter Harris, and Carles Aris -- 20. Wavelet Packets Algorithm for Metabolite Quantification in Magnetic Resonance Spectroscopy and Chemical Shift Imaging / Luca T Mainardi, Sergio Cerutti, Daniela Origgi, and Giuseppe Scotti -- 21. Cramér-Rao Bound Analysis of Spectroscopic Signal Processing Methods / Sophie Cavassila, Dirk van Ormondt, and Danielle Graveron-Demilly.
  • Lomb's algorithm and the Hilbert transform -- Modeling -- Volterra series -- Wiener series -- Poisson-Wiener series -- Decomposition of multichannel data -- Causality.
  • Chapter 1. Basic Tasks of Signal Processing in Spectroscopy -- Chapter 2. The Role of Quantum Mechanics in Signal Processing -- Chapter 3. Exact Quantum-Mechanical, Pade-Based Recovery of Spectral Parameters -- Chapter 4. Harmonic Transients in Time Signals -- Chapter 5. Signal-Noise Separation via Froissart Doublets -- Chapter 6. Machine Accurate Quantification and Illustrated Signal-Noise Separation -- Chapter 7. Pade Processing for MR Spectra from In Vivo Time Signals -- Chapter 8. Magnetic Resonance in Neuro-Oncology -- Chapter 9. Pade Quantification of Malignant and Benign Ovarian MRS Data -- Chapter 10. Breast Cancer and Non-Malignant Breast Data -- Chapter 11. Multiplet Resonances in MRS Data from Normal and Cancerous Prostate -- Chapter 12. Recapitulation of Pade-Optimized Processing of Biomedical Time Signals.
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  • Unlike detecting constitutively expressed targets, immunohistochemical detection of labile, low abundance, and short-lived signal transduction molecules can be a very difficult task. In Signal Transduction Immunohistochemistry: Methods and Protocols, IHC experts contribute detailed protocols addressing the numerous challenges of signal-transduction immunohistochemistry (ST-IHC). Beginning with a set of introductory chapters, the volume moves on to cover techniques used for the preservation of antigens and their unmasking, protocols in digital imaging and image analysis of stained cells and tissues, high-throughput data collection and data analysis, and techniques used in neuroscience as well as cancer and stem cell research. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Signal Transduction Immunohistochemistry: Methods and Protocols serves as an ideal guide for novices and as a bastion of inspiring ideas to be exploited by experienced researchers on the lookout for new experimental tricks and hints.
  • "The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blockade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study."--Back cover
  • The cardiovascular system provides blood circulation throughout the body and is essential for our survival. The major components of the circuitry--the heart, the valves, and the vasculature--require precise signaling events for their prenatal morphogenesis and postnatal homeostasis. Here, we describe the role of cell signaling in cardiovascular biology. In the arterial system, VEGF/Vegfr-2 signaling is essential for vascular remodeling. A pulse of VEGF/Vegfr-2 signaling in the vascular adventitia within hours after vascular injury activates Sca1+ tissue stem cells to differentiate into adventitial and neointimal cells, forming the neointima that occludes the vessel. In the myocardium, calcineurin/NFAT signaling controls cardiac fiber orientation and the expression of dystrophin, a-dystrobrevin, and utrophin--components of the dystrophin glycoprotein complex frequently found abnormal in patients with Duchenne, Becker, or other muscular dystrophies. Deletion of calcineurin in the myocardium results in cardiomyopathy, a phenotype similar to that observed in Duchenne muscular dystrophy patients. In the secondary heart field, calcineurin/NFATc1 signaling is required for semilunar valve morphogenesis. Conditional ablation of calcineurin or NFATc1 causes regression of heart valve primordium, leading to complete absence of the aortic and pulmonic valves, severe valve regurgitation, and perinatal lethality. These studies demonstrate novel functions and molecular mechanisms of cell signaling in three facets of cardiovascular biology.
  • G-protein-coupled receptor signaling -- Implication of G-proteins in cardiocascular diease / Madhu B. Anand-Srivastava -- B-adrenoceptor-linked signal transduction mechanisms in congestive heart failure / Melissa R. Dent...[et al.] -- Cardic G(alpha)s and G(alpha)i modualte sympathetic versus parasympathetic mechanisms on hyperhomocysteinemia / Thoma P. Vacek...[et al.] -- The role of the beta-adrenergic signal transduction pathway in myocardial protection / Johan Moolman...[et al.] -- Angiotensin II signaling in vascular physiology and pathophysiology / Neils Engberding, Kathy K. Greindling -- Angiotensin II signaling: cell growth and apoptosis / Stephen W. Shaffer, Mahmood S. Mozaffari -- Redox signaling -- Thioredoxin signaling in the ischemic heart / Dipak k. Das, Shyamal K. Goswami -- Relationship between redox regulation and B-adrenergic responses in the heart / Belma Turan -- Role of hyperglycemia and redox-induced signaling in vascular complications of diabetes / Ashok K. Srivastava, Madhu B. Anand-Srivastava -- Methylglyoxal and insulin resistance / Lingyun Wu -- Growth factor signaling -- Role of growth factor receptor transactivation in vasoactive peptide-induced signaling pathways in vascular smooth muscle cells / Ali Boullegue, Ashok K. Shrivastava -- Identifying the cellular and molecular events associated with the divergent phenotypes of cardic hypertrophy / Angelino Calderone -- Regulatory role of TGF-B in cardic myofibroblast function and post-MI cardic Fibosis: key roles of Smad7 and c-Ski / Ian M.C. Dixon...[et al.] -- The signaling duel between virus and host: Impact on Coxsackieviral Pathogenesis / Xiaonung Si...[et al.] -- Therapeutic angiogenesis and vasculogenesis for ischemic disease / Nilanjana Maulik -- VEGF signaling: a therapeutic target for cardiovascular disease / Dhanya Handrasekharan Rajalakshmi...[et al.] -- Myristoyl-CoA: protein N-Myristoyltransferase and Myristoyl-CoA binding protein from bovine cardiac muscle / Ponniah Selvakumar, Rajendra K. Sharma -- Calcium signaling -- Ca(2+)/calmodulin-dependent protein kinase II signaling in vascular smooth muscle / Suzanne J. House...[et al.] -- The KCa3.1 channel of endothelial cells as new target for EDHF-based control of cascular tone: from structure to regulation and pharmacological properties / Umberto Banderali...[et al.] -- Adipokine signaling -- Leptin signaling in the cardiovascular system / Morris karmazyn...[et al.] -- AMPK regulation of cardiac metabolism in heart disease / Ding An, Min-Suk Kim, Brian Rodigues.
  • 2009 ClinicalKey
    "A reference on cellular-signalling processes, Signal Transduction second edition details the sources, key observations, and experiments that set the scene for recent and current scientific endeavour. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors." "The book further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fated decisions, cell differentiation, and cell transformation. This revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes"--Book jacket.
  • Machine generated contents note: 1 Regulation of SignalTransduction by the Fcy Receptor Family -- Members and Their Involvement in Autoimmunity -- Coggeshall, K.M. (Oklahoma City, Okla.) -- 30 The Role ofTNF/TNFR in Organ-Specific and Systemic -- Autoimmunity: Implications for the Design of Optimized 'Anti-TNF' -- Therapies -- Kollias, G.; Kontoyiannis, D.; Douni, E.; Kassiotis, G. (Vari) -- 51 CD40 Signaling and Autoimmunity -- Cheng, G. (Los Angeles, Calif.); Schoenberger, S.P. (San Diego, Calif.) -- 62 TGF-j: Receptors, Signaling Pathways and Autoimmunity -- Chen, W; Wahl, S.M. (Bethesda, Md.) -- 92 lnterleukin-2 Signaling and the Maintenance of Self-Tolerance -- Nelson, B.H. (Seattle, Wash.) -- 113 Role of the B7-CD28/CTLA-4 Pathway in Autoimmune Disease -- Chang, T.T.; Kuchroo, VK.; Sharpe, A.H. (Boston, Mass.) -- 131 AbnormalT Lymphocyte Signal Transduction in Systemic Lupus -- Erythematosus -- Kammer, G.M. (Winston-Salem, N.C.); Tsokos, G.C. -- (Bethesda, Md./Silver Spring, Md.) -- 151 Lyn/CD22/SHP-1 and Their Importance in Autoimmunity -- Blasioli, J.; Goodnow, C.C. (Canberra) -- 161 Regulation of Immune Responses by E3 Ubiquitin-Protein Ligases -- Fang, N.; Fang, D.; Wang, H.-Y.; Altman, A.; Liu, Y.-C. (San Diego, Calif.) -- 176 Keeping theT-Cell Immune Response in Balance: Role of Protein -- Tyrosine Phosphatases in Autoimmunity -- Mustelin, T. (La Jolla, Calif.) -- 191 Author Index -- 192 Subject Index.
  • Assessing the response of cells to TLR stimulation / Kiyoshi Takeda, Masahiro Yamamoto, and Kenya Honda -- TLR ligands in experimental settings their purity and specificity / Min-Fu Tsan -- Analysis of TLR expression, regulation, and signaling / Hui Xiao, Xiaoxia Li, and Derek W. Abbott -- Intracellular trafficking of toll-like receptors / Harald Husebye ... [et al.] -- The role of small RhoGTPases in TLR signaling / Monica Ruse and Ulla G. Knaus -- Use of engineered [beta]-lactamase fragment complementation to detect the associations of toll-like receptors and signaling adaptors / Hyun-Ku Lee and Peter S. Tobias -- Use of toll-like receptor chimeras to dissect mechanisms of receptor localization and signaling / Tadashi Nishiya and Anthony L. DeFranco -- Engagement of toll-like receptors modulates chemokine receptor signaling / Chong-Shan Shi and John H. Kehrl -- Role of toll-like receptor signaling in central nervous system infections / Tammy Kielian -- The influence of injury on toll-like receptor responses / Thomas J. Murphy ... [et al.].
  • Tools to Study Signaling -- Cell-Cycle Signaling, Epigenetics, and Nuclear Function -- Signaling in the Endothelium -- Rapid Signaling Pathways -- Growth Factors Signaling -- Ion Signaling and Electrophysiological Function -- Lipid Signaling Pathways in the Heart -- Heart Mitochondria: A Receiver and Integrator of Signals -- Signaling Pathways in Cardiovascular Development -- Signaling in Congenital Heart Disease -- Signaling in the Aging Heart -- Signaling in Endomyocarditis -- Signaling in Hypertension -- Gene Expression and Signaling Pathways in Myocardial Ischemia -- Signaling in Hypertrophy and Heart Failure -- Signaling in Diabetes and Metabolic Syndrome -- Dysrhythmias/Channelopathies and Signaling Pathways -- Signaling in Atherosclerosis -- Stem Cells Signaling Pathways in the Heart -- Cardioprotection and Signaling Pathways -- Targeting Signaling Pathways -- Signaling and the Frontiers Ahead.
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    Targeting receptor tyrosine kinase mutations in cancer / Mark Pearson and Doriano Fabbro -- The RET proto-oncogene: a valuable target for thyroid cancer therapy / Brigitte M. Pützer -- Inhibitors of HER/erbB receptors: biological bases and clinical applications / Vincenzo Damiano ... [et al.] -- Phosphatases as promising targets for cancer therapy / Marc Creus and Heinz Zoller -- Targeting the mTOR pathway for cancer therapy / Sabita Sankar -- Targeting MAP kinase signaling pathways for the treatment of cancer / Maria Julia Marinissen and Mario Chiariello -- Cell death-based therapy / Gerolama Condorelli ... [et al.] -- Signaling molecules and therapeutic targets in gliomas / Hrvoje Miletic, Parisa Monfared and Andreas H. Jacobs -- Identifying and targeting genes involved in childhood leukemia / Jenny Yeung and Hugh J.M. Brady -- Receptor binding peptides for receptor mediated endoradiotherapy in oncology / Walter Mier, Uwe Haberkorn and Michael Eisenhut.
  • This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
  • This text describes research suggesting that abnormal activation of signaling pathways is a critical event in cancer pathogenesis, and describes the emerging ability to design small molecules, protein therapeutics, and other forms of targeted cancer therapies.
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  • 1. Abdominal Pain -- 2. Abnormal Vaginal Bleeding -- 3. Amenorrhea -- 4. Anemia -- 5. Anxiety -- 6. Arthralgia -- 7. Back Pain -- 8. Behavior Problems in Children -- 9. Bleeding and Bruising -- 10. Blood in Stool -- 11. Breast Masses and Nipple Discharge -- 12. Chest Pain -- 13. Child Abuse -- 14. Confusion -- 15. Congestion -- 16. Cough -- 17. Depression -- 18. Diarrhea -- 19. Dizziness -- 20. Earache -- 21. Family Discord -- 22. Fatigue -- 23. Fever -- 24. Headache -- 25. Health Maintenance -- 26. Heartburn -- 27. Hypertension -- 28. Jaundice -- 29. Lower Extremity Pain and Swelling -- 30. Lymphadenopathy -- 31. Menopause --- 32. Neck Pain -- 33. Pelvic or Genital Pain -- 34. Polyuria -- 35. Rashes -- 36. Seizures -- 37. Sexual Dysfunction -- 38. Shortness of Breath -- 39. Sleep Disorders -- 40. Sore Throat -- 41. Substance Abuse -- 42. Urinary Problems -- 43. Vaginal Discharge -- 44. Generalized Weakness -- 45. Weight Change
  • Eyelids -- Orbit -- Conjunctiva -- Episclera and sclera -- Cornea -- Anterior chamber -- Intraocular pressure and angle -- Iris -- Pupils -- Lens -- Vitreus -- Optic nerve head -- Fundus -- Ocular motility -- Systemic signs.
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  • Companion videos presents step-by-step procedures for splinting, arthrocentesis, injections, and reduction of fractures and dislocations. The book's Fracture Index illustrates every posssible fracturee of each bone.
  • The treatment of humeral fractures is a complex issue and the source of considerable controversy. In the case of fractures of the proximal humerus, early range of motion is the main aim of treatment. If a fracture modifies the anatomy or function of the glenohumeral and scapulothoracic joints, the surgeon must adhere meticulously to treatment principles in order to ensure a satisfactory outcome. Humeral shaft fractures are frequent, accounting for 1% to 3% of all fractures in adults; while excellent functional results have been reported with nonoperative management, open reduction and internal fixation is preferred in specific clinical settings. In contrast, intra-articular fractures of the distal humerus are frequently complex and full functional recovery is difficult to achieve. This volume clearly explains the concepts that are central to an understanding of humeral fractures from the proximal to the distal tip. Indications for different forms of treatment, including nonsurgical, are presented in detail, and all of the commonly used fixation techniques are described with the help of high-quality illustrations. Further important aspects such as complications, rehabilitation, and treatment of sequelae are also fully considered. This book will be an invaluable and comprehensive aid for all surgeons who treat humeral fractures.
  • Sims' 'Symptoms in the Mind' has, since its first publication in 1988, become established as a leading introductory textbook on clinical psychopathology. This edition has been fully updated to include advances in neuropsychology and cognitive neuroscience since the third edition.
  • Fundamental concepts of descriptive psychopathology -- Eliciting the symptoms of mental illness -- Consciousness and disturbed consciousness -- Attention, concentration, orientation, and sleep -- Disturbance of memory -- Disorder of time -- Pathology of perception -- Delusions and other erroneous ideas -- Disorder of the thinking process -- Disorder of speech and language -- Insight -- The disordered self -- Depersonalization -- Disorder of the awareness of the body -- The psychopathology of pain -- Affect and emotional disorders -- Anxiety, panic, irritability, phobia, and obsession -- Disorders of volition and execution -- The expression of disordered personality -- Psychopathology and diagnosis.
  • Lessons Learned from the Aviation Industry: Surgical Checklists / Stig Müller and Hitendra R. H. Patel -- Human Factors, Nontechnical Skills, and Surgical Training / Stig Müller, Waleed Al-Singary and Hitendra R. H. Patel -- Current State of Laparoscopic and Robotic Surgery / Jens J. Rassweiler, Marcel Hruza, Thomas Frede and Salvatore Micali -- Simulation and Training in Minimally Invasive Surgery / Sonal Arora, Shabnam Undre and Roger Kneebone -- Value of Virtual Reality in Medical Education / Amina A. Bouhelal, Hitendra R. H. Patel and Bijendra Patel -- The MIMIC Virtual Reality Trainer: Stepping into Three-Dimensional, Binocular, Robotic Simulation / Steven M. Lucas and Chandru P. Sundaram -- Laparoscopic Cholecystectomy Skills Acquisition and Procedural Proficiency in Novices Using Virtual Reality / Amina A. Bouhelal, Hitendra R. H. Patel and Bijendra Patel -- Lesson Learnt from the Military Surgeons Using Simulation in Trauma Surgery / Simon S. Fleming and John-Joe Reilly -- Clinical and Educational Benefits of Surgical Telementoring / Knut Mague Augestad, Taridzo Chomutare, Johan G. Bellika, Andrius Budrionis and Rolv-Ole Lindsetmo, et al. -- Portable Learning and Multimedia in Surgical Training / Narinderjit Singh Kullar, Stig Müller and Hitendra R. H. Patel.
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  • Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjögren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.
  • Noninvasive metabolic assessment of single cells / David K. Gardner -- Laser capture microdissection for analysis of single cells / Nobuki Nakamura ... [et al.] -- Fluorescence in situ hybridization (FISH) on single cells (sex determination and chromosome rearrangements) / Paul N. Scriven and Caroline Mackie Ogilvie -- Single cell PCR for PGD : methods, strategies, and limitations / Karen Sermon and Martine De Rycke -- Real-time quantitative PCR measurement of male fetal DNA in maternal plasma / Bernhard Zimmermann ... [et al.] -- Cell-free fetal DNA plasma extraction and real-time PCR quantification / Jill L. Maron, Kirby L. Johnson, and Diana W. Bianchi -- LATE-PCR and allied technologies : real-time detection strategies for rapid, reliable diagnosis from single cells / Kenneth E. Pierce and Lawrence J. Wangh -- Efficient isothermal amplification of the entire genome from single cells / Karen V. Schowalter, Jolene R. Fredrickson, and Alan R Thornhill -- Comparative genomic hybridization on single cells / Lucille Voullaire and Leeanda Wilton -- Generation of amplified RNAs and cDNA libraries from single mammalian cells / James Adjaye -- Real-time PCR to measure gene expression in single cells / Dagan Wells -- Gender determination and detection of aneuploidy in single cells using DNA array-based comparative genomic hybridization (array CGH) / Dong Gui Hui, Xin Yuan Guan, and Nicole Hussey -- Microarray technology for mutation analysis of low template DNA samples / Chelsea Salvado and David Cram.
  • The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
  • Single Incision Laparoscopic and Transanal Colorectal Surgery provide a comprehensive and state-of-the art review of single incision laparoscopic and transanal colorectal surgery. The text concentrates on surgical techniques and tricks in single incision laparoscopic and transanal surgery with detailed descriptions of the techniques, as well as indications and limitations of the procedures. The newly available evidence on these procedures is emphasized and all procedures are richly illustrated with diagrams and photos. Written by experts in their fields, Single Incision Laparoscopic and Transanal Colorectal Surgery is a valuable resource for general surgeons, colon and rectal surgeons, laparoscopic GI surgeons, surgical residents and fellows in training interested in these two rapidly developing fields in colorectal surgery.
  • Single molecule biology 2009
    The "single molecule" paradigm / Alex E. Knight -- Single molecule studies of myosins / Rachel E. Farrow ... [et al.] -- Single molecule experiments and the kinesin motor protein superfamily : walking hand in hand / Lukas C. Kapitein and Erwin J.G. Peterman -- Force-generating mechanisms of dynein revealed through single molecule studies / Kazuhiro Oiwa and Hiroaki Kojima -- The bacterial flagellar motor / Yoshiyuki Sowa and Richard M. Berry -- Single molecule studies of chromatin structure and dynamics / Sanford H. Leuba and Laurence R. Brewer -- Single molecule studies of nucleic acid enzymes / Samir M. Hamdan and Antoine M. van Oijen -- Single molecule studies of prokaryotic translation / Colin Echeverría Aitken ... [et al.] -- Single ion channels / David Colquhoun, Remigijus Lape, and Lucia Sivilotti -- Single molecule fluorescence in membrane biology / Lydia M. Harriss and Mark I. Wallace -- Single molecule microarray analysis / Jan Hesse ... [et al.].
  • ch. 1. Single Molecule Detection in Liquids and on Surfaces under Ambient Conditions: Introduction and Historical Overview / Jörg Enderlein, Richard A. Keller and Christoph Zander, p. 1-19 -- ch. 2. Theoretical Foundations of Single Molecule Detection in Solution / Jörg Enderlein and Christoph Zander, p. 21-67 -- ch. 3. Conceptual Basis of Fluorescence Correlation Spectroscopy and Related Techniques as Tools in Bioscience / Jerker Widengren and Ülo Mets, p. 69-120 -- ch. 4. Surface-Enhanced Raman Scattering (SERS - A Tool for Single Molecule Detection in Solution / Katrin Kneipp, Harald Kneipp, Irving Itzkan, Ramachandra R. Dasari and Michael S. Feld, p. 121-144 -- ch. 5. Single Molecule Detection on Surfaces with the Confocal Laser Scanning Microscope / Martin Böhmer and Jörg Enderlein, p. 145-183 -- ch. 6. Spectroscopy of Individual Photosynthetic Pigment-Protein Complexes / J. Wrachtrup, T.J. Aartsma, J. Köhler, M. Ketelaars, A. M. van Oijen, M. Matsushita, J. Schmidt, C. Tietz and F. Jelezko, p. 185-229 -- ch. 7. Single Dye Tracing for Ultrasensitive Microscopy on Living Cells / Gerhard J. Schütz and Hansgeorg Schindler, p. 231-245 -- ch. 8. Single Molecule Identification in Solution: Principles and Applications / M. Sauer and C. Zander, p. 247-272 -- ch. 9. Studying Molecular Motors on the Single Molecule Level / Y. Ishii, A. H. Iwane, H. Yokota, Y. Inoue, T. Wazawa, M. Nishiyama, H. Tanaka, K. Kitamura and T. Yanagida, p. 273-292 -- ch. 10. The Chemistry of a Single Enzyme Molecule / Robert Polakowski, Michael Eggertson, Douglas B. Craig and Norman J. Dovichi, p. 293-301 -- ch. 11. Single Molecule Detection of Specific Nucleic Acid Sequences / Alonso Castro, p. 303-321 -- ch. 12. Single Molecule Detection in the Near-Infrared / Steven A. Soper, Musundi Wabuyele, Clyde V. Owens and Robert P. Hammer, p. 323-362.
  • Also available: Print – 2010
    Star polymer surface passivation for single-molecule detection / Jürgen Groll and Martin Moeller -- Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation: phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy / Anirban Chakraborty ... [et al.] -- Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast / John Abelson, Haralambos Hadjivassiliou and Christine Guthrie -- Nanovesicle trapping for studying weak protein interactions by single-molecule FRET / Jaime J. Benítez, Aaron M. Keller and Peng Chen -- Droplet confinement and fluorescence measurement of single molecules / Lori S. Goldner, Ana M. Jofre and Jianyong Tang -- Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs / Abhinav Nath ... [et al.] -- Single-molecule spectroscopy using microfluidic platforms / Samuel Kim and Richard N. Zare -- Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning / Julian Weghuber ... [et al.] -- Analysis of complex single-molecule FRET time trajectories / Mario Blanco and Nils G. Walter -- Single-molecule fluorescence studies of intrinsically disordered proteins / Allan Chris M. Ferreon ... [et al.] -- Measuring the energetic coupling of tertiary contacts in RNA folding using single molecule fluorescence resonance energy transfer / Max Greenfield and Daniel Herschlag -- A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis / Jingyi Fei ... [et al.] -- Watching individual proteins acting on single molecules of DNA / Ichiro Amitani ... [et al.] -- DNA curtains for high-throughput single-molecule optical imaging / Eric C. Greene ... [et al.] -- Scanning FCS for the characterization of protein dynamics in live cells / Zdenĕk Petrás̆ek, Jonas Ries and Petra Schwille -- Observing protein interactions and their stoichiometry in living cells by brightness analysis of fluorescence fluctuation experiments / Yan Chen ... [et al.] -- Detection of individual endogenous RNA transcripts in situ using multiple singly labeled probes / Arjin Raj and Sanjay Tyagi -- Single mRNA tracking in live cells / Hye Yoon Park, Adina R. Buxbaum and Robert H. Singer -- Single-molecule sequencing: sequence methods to enable accurate quantitation / Christopher Hart ... [et al.] -- Real-time DNA sequencing from single polymerase molecules / Jonas Korlach ... [et al.].
  • Also available: Print – 2010
  • Single-access laparoscopic surgery (SALS), performed using a single transumbilical access, has recently proved to bring advantages over other forms of laparoscopic surgery due to the reduction in the number of incisions and the consequent decrease in morbidity, less blood loss and postoperative pain. Furthermore, cosmesis may be improved because incision within the umbilicus renders surgery virtually scarless. Nevertheless, as with all new surgical concepts, questions may be raised regarding safety, usefulness, and appropriateness. This book analyzes the use of SALS for different indications and abdominal surgical procedures based on a careful literature review of the experience of the most important surgical teams employing this approach and also the authors' personal observations. The coverage is broad, encompassing, for example, the role of SALS in appendectomy, repair of abdominal wall defects, cholecystectomy, gastric surgery, nephrectomy, splenectomy, hemicolectomy, and pancreatic, liver, and gynecological surgery. Resident surgeons specializing in laparoscopy, researchers, and related healthcare professionals will find Single-Access Laparoscopic Surgery to be an invaluable source of information in an area which deserves to receive detailed attention.
  • Cytokines are essential in the orchestration of effective innate and adaptive immune responses. Immunologists have focused extensively on identifying cytokines, and the cells that produce cytokines, yet there is still little understanding of the complex dynamics that govern cytokine responses in vivo during infection. Chapter 1 provides a general introduction to the cytokine signaling induced by innate and adaptive immune responses. Emphasis is placed on the activation of the signal transducers and activator of transcription (STAT) family of transcription factors by numerous cytokines because monitoring of STAT activation is a sensitive biochemical marker of the cytokine response. Chapter 2 describes the in vivo innate inflammatory response to poxvirus infection. Chapters 3 deals with adaptive immunity and specifically the cytokine responses elicited in vivo by antigen specific T cell activation. Chapter 2 presents experiments demonstrating that early after in vivo exposure to various microbe-associated molecular patterns, STAT1 and STAT3 activation is potently induced in splenic dendritic cells and T cells. Mice with targeted gene deletions were used to identify toll-like receptors (TLRs), interferons, and interleukin-6 (IL-6) as necessary for early STAT activation. These experiments with reductionist microbial ligands demonstrated the feasibility of analyzing the cytokine response to infection with an intact pathogen in vivo. Chapter 2 goes on to describe the innate cytokine response to viral infection in experiments comparing the immune response to two closely related poxviruses: vaccinia and ectromelia (mousepox). Early and robust STAT1 and STAT3 activation was found to strongly correlate with survival of poxvirus infection. In addition, different modes of innate immune recognition distinguished vaccinia from ectromelia infection with toll-like receptor 2 (TLR2) activation being unique to immune recognition of vaccinia and not of ectromelia. These results suggest that different modes of early innate immune recognition could play an essential role in the containment of poxvirus infections and underlie the strict host species specificity of poxviruses. Chapter 3 deals with the paracrine cytokine responses elicited by antigen specific T cell activation in vivo. Using a T cell receptor (TCR) transgenic model we found profound and sustained activation of STAT5 in the Foxp3+ T regulatory cells (T regs) of mice immunized with a model peptide antigen after the adoptive transfer of antigen specific T cells. STAT5 activation in T regulatory cells was found to be interleukin-2 (IL-2) dependent and IL-2 signals elicited T regulatory cell proliferation and enhanced suppressive functions. Infection with vaccinia virus yielded a similar pattern of STAT5 activation in T regulatory cells, and STAT5 signaling was found to be even more potent under conditions of preexisting immune memory. These experiments revealed that antigen specific T-cell activation is intrinsically linked via paracrine IL-2 production to the activation of the polyclonal T reg repertoire, a response mechanism that could prevent autoimmunity. Chapter 3 also describes the regulation of autocrine IL-2 signaling during antigen specific T cell activation. Surprisingly, following TCR stimulation in vivo DO11 T cells did not display potent STAT5 activation even though these cells produced IL-2 and expressed the high affinity IL-2 coreceptor CD25. Only upon secondary TCR stimulation was robust autocrine IL-2 dependent STAT5 activation observed. Overall, these experiments demonstrate the nuances of IL-2/STAT5 signaling across numerous innate and adaptive cells populations revealing that in vivo T regulatory cells are extremely sensitive to antigen specific T cell activation. Targeting IL-2 signals specifically to antigen specific T cells while blocking IL-2 activation of T regs could enhance the efficacy of vaccination.
  • The human hematopoietic system is a complex mixture of morphologically and functionally distinct cell types. Using high-dimensional single-cell cytometry, functional behaviors in a wide number of cell types can be monitored simultaneously ("deep profiling"), enabling new insights into the structure and relationships of the overall system. Presented in this dissertation are several incremental technical and informatic steps that contributed to this holistic approach to single-cell biology. Using 30-parameter mass cytometry, deep profiling was used to recover the developmental continuum of healthy bone marrow and create a detailed map of the atypical functionally related cell types in a case of oligoclonal pediatric acute myeloid leukemia. These examples demonstrate the utility of a single-cell deep profiling paradigm in attaining an informative snapshot of healthy and malignant human hematopoiesis.
  • Complex organisms contain many individual cells that express unique sets of genes. Unraveling the full complexity of organisms requires an understanding of the unique gene expression signatures of individual cells. Obtaining these cellular signatures enables a deeper understanding of the underlying biological processes, including development and aging. Model organisms, such as C. elegans, are ideal platforms for single-cell studies, offering true single-cell resolution. In the nematode, C. elegans, each of its 959 somatic cells are uniquely identifiable in every individual. Through high-resolution 3D imaging of in-situ fluorescent reporters, expression levels can be observed in all 959 cells. The key to making this powerful system a viable source of discovery through large-scale, high-resolution gene expression analysis requires automation of the annotation process. This dissertation describes computational approaches to identifying single-cells to obtain high-resolution gene expression levels in adult C. elegans. These approaches include an image processing pipeline enabling both manual and automatic annotation of images. For the latter, I describe a set of automatic annotation methods developed for single-cell identification in 3D confocal images of adult C. elegans utilizing machine learning approaches. These approaches automatically assign a set of labels to cells based on (1) cell-lineage, (2) tissue type or (3) the anatomical region occupied within the worm. Finally, this dissertation describes the types of biological insights researchers can gain from such high-resolution data. In particular, it develops a novel gene expression analysis method that combines the known cell lineage and expression levels of 96 genes in 363 single-cells in the first larval stage of C. elegans. Together, these methods provide C. elegans researchers with a powerful toolkit for performing single-cell gene expression analysis of worms. This work enables studies in the field of development and, for the first time, aging at the single-cell resolution using automated annotation approaches in the adult worm.
  • Since the first successful detection single molecules over two decades ago, single-molecule spectroscopy has developed into a burgeoning field with a wealth of experiments at room temperature and inside living cells. Probing asynchronous and heterogeneous populations in situ, one molecule at a time, is not only desirable, but critical for many biological questions. Further, super-resolution imaging based on sequential imaging of sparse subsets of single molecules, has seen explosive growth within the last five years. This dissertation describes both the application of live-cell single-molecule imaging as an answer to important biological questions, and development and validation of fluorescent probes for targeted super-resolution imaging.
  • Kinesin family proteins are nanoscale motors involved in many essential biological processes, such as intracellular transport and cell division. The biological function of most kinesin motors is to use the energy from ATP hydrolysis to move cargo through a crowded cellular environment, quickly taking 8-nm steps along cytoskeletal microtubules. By maintaining its two motor domains (heads) out of phase, kinesin can complete hundreds of steps per encounter with the microtubule, and can do so against pN-scale loads. The physiological role of kinesin is directly related to its movement and in this dissertation I present several single-molecule studies where the force-dependent motion of individual kinesin motors was studied using optical trapping techniques. In humans, the kinesin superfamily includes over forty genes encoding different kinesin proteins, classified into 15 families, and motors from several families were studied in this work. Optical traps use lasers to detect the position of biological molecules, at nm-scale resolution, and to directly manipulate them by applying pN-scale forces. In this dissertation, I present two novel optical traps. The first uses highly linear electro-optic deflection of the laser light to create an instrument with fast feedback that is optimized for work with kinesin motors. The second instrument, an "Optical Torque Wrench", is a trap that can apply both forces and torques on birefringent particles. By controlling the light polarization in the sample plane, the rotation of nanofabricated quartz cylinders can be controlled in real time while the applied torque is measured directly. The functionalized particles can be used to twist DNA or other biological molecules. The kinesin motor domains are coordinated during stepping and the inter-head communication is believed to be conferred by the neck linker, a 14-amino acid structural element connecting the head to the common coiled-coil stalk. By extending this segment, we could examine its role in gating the mechanochemical cycle. A six-amino acid insert in the neck linker of a cysteine-light human kinesin construct led to unexpected ATP-dependent backstepping under load. These observations could be explained by a branched pathway where both ATP unbinding and hydrolysis were gated by the direction of the neck linker. Lengthening the neck linker also led to futile hydrolysis. Further experiments on the effects of neck linker length were done with a series of Drosophila Kinesin-1 mutants, with one to six extra residues in the neck linker. The rate of force-dependent rear head release and the internal strain developed during stepping was determined from force-dependent velocities and we also found that the mechanism of detachment from the microtubule depends on the direction of load. The heterotrimeric Kinesin-2 motors are unique in that they are the only kinesin family motors that consist of two different catalytic domains. Here, the mammalian Kinesin-2, KIF3A/B, was studied in detail by performing optical trapping experiments with both the wild-type dimer and with homodimers (KIF3A/A and KIF3B/B). A pathway that incorporates the individual catalytic cycles for KIF3A and KIF3B could explain all force- and ATP-dependent kinetics and surprisingly we found that the run lengths for KIF3A/B were significantly shorter than for Kinesin-1. Furthermore, motors with the weakly force-dependent KIF3A head "slipped" and exhibited short run lengths that were rescued under no load, indicating that KIF3A/B combines a Kinesin-1-like motor domain (KIF3B) with a unique and "weak" one (KIF3A). Finally, I present motility experiments where force-dependent kinetics were explored for several other kinesin family motors. KIF17 (Kinesin-2) and CENP-E (Kinesin-7) are robust, processive motors whereas KIF4A, a Kinesin-4 motor, is fast but unable to sustain significant loads. These results, together with those for Kinesin-1, KIF3A/B (Kinesin-2), and other motors, show that forces are needed fully reveal the motor characteristics and differences between various kinesin proteins. They also illustrate the remarkable diversity within the kinesin superfamily.
  • Single-molecule, super-resolution fluorescence microscopy is a powerful technique for studying biological systems because it reveals details beyond the optical diffraction limit (on the 20-100 nm scale) such as structural and conformational heterogeneity. Further, single-molecule imaging measures distributions of behaviors directly through the interrogation of many individual molecules and reports on the nanoscale environment of molecules. Sub-diffraction imaging adds increased resolution to the advantages of fluorescence imaging over the techniques of atomic force microscopy and electron microscopy for studying biological structures, which include imaging of large fields of view in aqueous environments, specific identification of protein(s) of interest by fluorescent labeling, low perturbation of the system, and the ability to image living systems in near real-time (limited by the time required for super-resolution sequential imaging). This dissertation describes the application of single-molecule and super-resolution fluorescence imaging to studying the huntingtin (Htt) protein aggregates that are a hallmark of Huntington's disease and that have been implicated in the pathogenesis of the disease. The intricate nanostructures formed by fibrillar Htt aggregates in vitro and the sub-diffraction widths of individual fibers mark the amyloids as important targets for high-resolution optical imaging. The characterization of Htt aggregate species is critical for understanding the mechanism of Huntington's disease and identifying potential therapies. Following an introduction to single-molecule, super-resolution imaging and Huntington's disease in Chapter 1, Chapter 2 describes the single-molecule methods, experimental techniques, Htt protein sample preparations, and data analysis performed in this dissertation. Chapter 3 discusses the development of super-resolution imaging of Htt protein aggregates and the validation of the images by atomic force microscopy. Chapter 4 continues the study of Htt by one- and two-color super-resolution with imaging of Htt protein aggregates over time from the initial protein monomers to the large aggregate assemblies of amyloid fibers. In Chapter 5, I detail our progress to-date in studying the earliest stages of Htt aggregation using zero-mode waveguide technology. Chapter 6 concludes the dissertation with a discussion of the results from additional projects comprising the effect of chaperonin proteins on Htt aggregation, extension of super-resolution Htt imaging to three dimensions, and cellular imaging of Htt aggregates. The future directions for these exciting projects are summarized with the expectation that research efforts directed in these areas will contribute to our understanding of Htt aggregation and Huntington's disease.
  • Transcription by RNAP is highly regulated in both prokaryotic and eukaryotic cells, and the ability of the cell to differentiate and respond to its environment is largely due to this regulation. During elongation, for example, RNAP is known to momentarily halt in response to certain cellular signals, and this pause state has been implicated in the regulation of gene expression in both prokaryotic and eukaryotic organisms. In addition, once RNAP reaches the end of a gene, it must reliably terminate and release the newly-transcribed RNA, providing another potential point of regulation within different cell types. Both of these steps are crucial to ensure proper gene expression. In this dissertation, I focus on transcription elongation by both prokaryotic and eukaryotic RNA polymerases, as well as their regulation through pausing and termination. To probe the role of RNA hairpins in transcriptional pausing, a novel single-molecule "RNA-pulling" assay was used to block the formation of secondary structure in the nascent transcript. Force along the RNA did not significantly affect transcription elongation rates, pause frequencies, or pause lifetimes, indicating that short "ubiquitous" pauses are not a consequence of RNA hairpins. Force-based single-molecule techniques were also used to study the mechanism and energetics of transcription termination in bacteria. The data suggest two separate mechanisms for termination: one that involves hypertranslocation of RNAP along the DNA, and one that involves shearing of the RNA:DNA hybrid within the enzyme. In addition, a quantitative energetic model is presented that successfully predicts the termination efficiency of both wild-type and mutant terminators. Finally, the implementation of a novel optical-trapping assay capable of directly observing transcription by eukaryotic RNA polymerase II (RNAPII) molecules is described. This approach was used to probe the RNAPII nucleotide-addition cycle, as well as the role of the trigger loop (a conserved subdomain) in elongation. The results are consistent with a Brownian ratchet model of elongation which incorporates a secondary NTP binding site, and the trigger loop was found to modulate translocation, NTP binding, and catalysis, as well as substrate selection and mismatch recognition by RNAPII.
  • Nucleic acids--DNA and RNA--are critical to life, involved in the storage and decoding of genetic information in the cell as well as the regulation and catalysis of specific biological processes. The function of a nucleic acid molecule is determined in large part by the structure it adopts, which in turn depends on its sequence. The mechanisms of sequence-directed nucleic acid folding remain incompletely understood, particularly for large RNA molecules. The work presented in this thesis uses single-molecule optical-trapping techniques to study nucleic acid folding, where reversible folding is induced and measured in individual molecules through the application of force. In Chapter 2 we demonstrate direct measurement of the full folding energy landscapes of DNA hairpins, which comprise a model system for studying nucleic acid secondary structure, and show how such landscapes are sensitive to sequence. In Chapter 3 we study the electrostatics of DNA hairpin folding by measuring trends in folding energies under different ionic conditions and comparing these trends with those predicted by Poisson-Boltzmann theory. Finally, in Chapter 4 we examine folding of the TPP riboswitch aptamer, an RNA molecule with complex secondary structure that also adopts tertiary structure upon binding a small-molecule ligand. We measured the folding energy landscape of the aptamer and perturbations of this landscape resulting from mutations and ligand binding, and propose a kinetic model to describe the coupling between aptamer folding and ligand binding. Taken together, the results presented here demonstrate the usefulness of the energy landscape framework for characterizing nucleic acid folding in conjunction with single-molecule measurements.
  • Single-molecule measurement techniques are providing fundamental information on the structure and function of biomolecules and are becoming an indispensable tool to understand how proteins work. During the last two decades, this field has grown at an almost exponential rate in terms of biological and biophysical applications. Single-molecule techniques have opened new fields of science that are at the crossroads of several disciplines such as biology, physics, chemistry, material science and computer science. These methods are often the approach of choice to clarify and better understand the structure and function of single proteins. This volume consists of up-to-date and comprehensive reviews of important and timely applications of different biological problems tackled by single-molecule methods; it also covers basic principles of operation, experiment and theory.In Single-molecule Studies of Proteins, expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.
  • RNA--a ubiquitous and versatile type of biopolymer that is critically involved in many of life's molecular processes--is produced sequentially in single-stranded form during transcription by RNA polymerase and has the propensity to fold back on itself into interesting structures of functional import. In nature, riboswitches are elegant examples of structured RNA that adopt alternate conformations in response to ligand binding and thereby affect gene expression. We have been able to probe riboswitch conformations in novel detail using single-molecule optical-trapping techniques. These experimental approaches supply a unique perspective on folding since the ability to apply force provides an effective handle on the real-time state of individual RNA molecules and a means of modulating that state. In this dissertation, I focus on three studies that explore adenine riboswitch conformations and mechanisms. Specifically, in the first, we dissect the folding landscape of the aptamer (ligand-binding domain) of an adenine riboswitch. Extending this endeavor to full riboswitch sequences, we probe the interplay of a riboswitch aptamer with its downstream expression platform (which executes the switch's regulatory role), and develop methods to do so both during and after transcription. The second study takes full advantage of the latter ability: In a complete adenine riboswitch controlling transcription, we directly observe cotranscriptional folding of the nascent RNA in which the adopted conformation dictates whether or not to terminate transcription. Finally, in a different adenine riboswitch controlling translation, we investigate switch conformational changes and identify a series of competing structural elements that kinetically trap the riboswitch conformation, implying that the initial, cotranscriptional fold of the riboswitch may determine its gene regulatory state. These efforts enhance our understanding of folding architectures in riboswitches, specifically, and in RNA, more broadly. They further highlight the importance of cotranscriptional folding, providing a novel window into the nascent development of RNA conformations.
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    The new era of biology in singulo / T. Ha and P.R. Selvin -- Single-molecule FRET with total internal reflection microscopy / C. Joo and T. Ha -- In vitro and in vivo FIONA and other acronyms for watching molecular motors walk / P.R. Selvin, T. Lougheed, M.T. Hoffman, H. Park, H. Balci, B.H. Blehm, and E. Toprak -- Colocalization of fluorescent probes: Accurate and precise registration with nanometer resolution / L.S. Churchman and J.A. Spudich -- Alternating-laser excitation of single molecules / A.N. Kapanidis, M. Heilemann, E. Margeat, X. Kong, E. Nir, and S. Weiss -- Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy / J.F. Beausang, Y. Sun, M.E. Quinlan, J.N. Forkey, and Y.E. Goldman -- Imaging gene expression in living cells at the single-molecule level / J. Xiao, J. Elf, G.-W. Li, J. Yu, and X.S. Xie -- Single-virus tracking in live cells / M.J. Rust, M. Lakadamyali, B. Brandenburg, and X. Zhuang -- Ultrasensitive imaging in live cells using fluorescent quantum dots / S. Courty and M. Dahan -- Imaging real-time gene expression in living systems / A.L. Wells, J.S. Condeelis, R.H. Singer, and D. Zenklusen -- Single-molecule imaging of stochastic signaling events in living cells / S. Matsuoka, Y. Miyanaga, T. Yanagida, and M. Ueda -- Fluorescence correlation spectroscopy in vitro and in vivo / E. Haustein and P. Schwille -- Optical traps to study properties of molecular motors / J.A. Spudich, S.E. Rice, R.S. Rock, T.J. Purcell, and H.M. Warrick -- High-resolution dual-trap optical tweezers with differential detection / C. Bustamante, Y.R. Chemla, and J.R. Moffitt -- Imaging and nanomanipulation of an actomyosin motor / S. Nishikawa, T. Komori, T. Ariga, T. Okada, M. Morimatsu, Y. Ishii, and T. Yanagida -- Single-molecule studies using magnetic traps / T. Lionnet, J.-F. Allemand, A. Revyakin, T.R. Strick, O.A. Saleh, D. Bensimon, and V. Croquette -- Probing polysaccharide and protein mechanics by atomic force microscopy / M. Rabbi and P.E. Marszalek -- Single-molecule analysis of nucleic acids and DNA-protein interactions using nanopores / M. Wanunu and A. Meller -- Single-molecule gold-nanoparticle tracking with high temporal and spatial resolution and without an applied load / A.R. Dunn and J. A. Spudich -- Advances in surface-based assays for single molecules / P.M. Fordyce, M.T. Valentine, and S.M. Block -- Hydrodynamic flow-stretching assay for single-molecule studies of nucleic acid-protein interactions / C.M. Schroeder, P.C. Blainey, S. Kim, and X.S. Xie.
  • Also available: Print – 2000
  • The near infrared range has long been known to be advantageous for biological imaging and sensing applications. In particular, the second near infrared window (1000 nm -- 1400 nm, NIR II) is characterized by low endogenous autofluorescence and deep tissue penetration due to reduced tissue scatter. To address the dearth of fluorophores in this window, this work focuses on utilizing the intrinsic near infrared photoluminescence of semiconducting single walled carbon nanotubes (SWNTs) to take advantage of this unique spectral region. First, SWNTs are made bio-inert and applied as fluorescent probes for highly specific cellular targeting using antibodies such as Rituxan and Herceptin. These probes were then used for the first whole animal fluorescent imaging using SWNTs in vivo following tail vein injection, including the observation of high SWNT accumulation in tumors. By implementing a surfactant exchange method to improve the fluorescence yield of SWNTs solubilized by phospholipid-polyethylene glycol, high magnification intravital microscopy of tumor vessels beneath thick skin was achieved. Further improvements were made to improve the fluorescence yield of the SWNT probes by utilizing a density gradient separation method which removed poorly fluorescent short tubes and nanotube bundles. Another separation method, ion-exchange chromatography was applied to isolate single chirality SWNTs and perform multicolor NIR imaging in vitro and in vivo. Finally, these bright, biocompatible nanotube fluorophores were used to achieve video rate imaging of mice in vivo during tail vein injection for dynamic contrast enhanced imaging through principal component analysis. The emission in the NIR II region allowed crisp anatomical resolution, confirmed by mock tissue phantom studies and Monte Carlo simulation.
  • Placement of endosseous implants in the posterior maxilla is often difficult because of a lack of supporting bone. Sinus augmentation procedures have therefore been extensively used for the treatment of the edentulous atrophic posterior maxilla prior to implant placement. This book describes in detail the most widely used sinus grafting techniques as well as some innovative variations, with full coverage of both lateral and crestal approaches. A key aim is to assist the practitioner in selecting the appropriate sinus grafting technique based on the evaluation of a number of parameters that are described in detail and codified in a simple and practical way. Up-to-date information is also provided on grafting materials and on potential complications of sinus augmentation procedures and their treatment.
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  • While the adult mammalian brain has a relatively limited regenerative capacity, it does contain pools of neural stem and progenitor cells that can give rise to new neurons and glia. The mechanisms that govern the production of new neurons in the adult brain are beginning to be well understood, but much less is known about the production of other cell lineages, in particular oligodendrocytes, from adult neural stem cells. Given the importance of oligodendrocytes in myelination, how they are generated in the adult brain is a question of fundamental importance for both normal and pathological conditions. Here we show that loss of SIRT1, a deacetylase that is crucial for metabolism and neuroprotection, enhances the production of both neural stem cells and oligodendrocyte progenitor cells in the adult brain and in vitro. Conditional deletion of SIRT1 in adult neural stem cells reveals a cell-autonomous action of SIRT1 in the generation of glia in the niche surrounding the subventricular zone. We find evidence that SIRT1 loss may alter the pool of proliferating oligodendrocyte progenitor cells by controlling the PDGF receptor a (PDGFR a) signaling pathway. SIRT1 loss increases acetylation of lysine 9 of histone H3 at the Pdgfra gene locus, affecting Pdgfra expression and activation of downstream PI3K-Akt and p38 MAPK signaling pathways in adult neural stem and progenitor cells. The observation that a drug-targetable deacetylase and downstream signaling pathways impact oligodendrocyte expansion may facilitate the generation of oligodendrocytes for stem cell therapies to treat injury and demyelinating diseases.
  • The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information{u2019}s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, {uF06A}C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information{u2019}s will help students and experienced researchers to understand and choose the best technology for their own purposes.
  • The enormous initial mistake -- The origins of six sigma -- Evolution -- Revolution -- Paradox -- Action and reaction -- Close enough or on target? -- Make more-- faster! -- Case studies -- The camera always lies -- Keeping it simple -- Why use control charts? -- Average and range control charts -- Origins and theory -- Charts for individuals -- Practical considerations -- Improving laboratories -- Beyond compliance.
  • This thesis project describes the synthesis and use of size-expanded ribonucleic acids (xRNAs) as unnatural components in small interfering RNAs (siRNAs), which serve as a novel set of steric probes for investigating and identifying size restrictions that exist in the active site of the RNA-induced silencing complex (RISC), a critical protein complex in the RNA interference (RNAi) mechanism. xRNAs are analogous to natural RNAs, in which they retain canonical Watson Crick base-pairing groups, except their nucleobases are expanded linearly by 2.4 Å via benzo-fusion. In this report, the synthesis of the entire set of four xRNA nucleosides and their photophysical properties are described. Two of the xRNA nucleosides (i.e. rxA and rxU) are then converted to their corresponding phosphoramidites for use in automated RNA synthesis to synthesize various sets of xRNA-substituted siRNA strands for biophysical and biological studies. RNAi activity studies in HeLa cells using a firefly/Renilla luciferase dual reporter assay showed that xRNA substitutions in the antisense strand displayed poor RNAi activity in the middle of the sequence (positions 7-14) but were generally well tolerated near the 5'- and 3'-ends. Most significantly, single xRNA substitutions at the 3'-end showed RNAi activity that was more potent than that of unmodified siRNAs. Thermal denaturation studies revealed small changes in melting temperature (+1.4 to --5.0 °C); xRNA substitutions in the middle were found to be more thermodynamically destabilizing whereas the ends were shown to be stabilizing. Serum stability studies showed that xRNA-containing siRNAs have longer half-lives in human serum than unmodified siRNAs. Finally, xRNA-substituted siRNA strands and duplexes showed interesting position-dependent fluorescent properties, while CD spectroscopy experiments revealed that xRNA-substituted siRNAs does not greatly distort the native A-form helical structure of the duplexes. Taken together, the data demonstrate the utility of xRNA nucleobases as size-expanded mechanistic probes for RNAi research.
  • Introduction -- A Note from Sweden: Recollection of Henrik Sjögren -- Myths, Pearls, and Tips Regarding Sjögren's Syndrome -- Providing Information to Referring Physicians and Patients -- Current Concepts on Classification Criteria and Disease Status Indexes in Sjögren's Syndrome -- Histopathology and Glandular Biopsies in Sjögren's Syndrome -- Imaging Technology in Sjögren's Syndrome: Non-invasive Evaluation of the Salivary Glands -- Genomics and Viruses in Sjögren's Syndrome -- Autoantibodies and Autoantigens in Sjögren's Syndrome -- B-cell Epitopes of Sjögren's Syndrome-Related Autoantigens Ro/SSA and La/SSB -- Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function -- Overview of Management of Dry Eye Associated with Sjögren's Syndrome -- Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjögren's Syndrome -- Oral and Dental Manifestations of Sjögren's Syndrome: Current Approaches to Diagnostics and Therapy -- Etiology and Pathogenesis of Sjögren's Syndrome with Special Emphasis on the Salivary Glands -- Otolaryngologic Manifestations of Sjögren's Syndrome -- Extraglandular Manifestations of Sjögren's Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations -- Therapy of Dermatologic, Renal, Cardiovascular, Pulmonary, Gynecologic, Gastro-enterologic, Urologic and Fibromyalgia Manifestations Including Special Considerations at the Time of Surgery -- Current Treatment of Extraglandular Manifestations with Disease-Modifying and Immunosuppressive Agents -- Lymphoproliferation and Lymphoma in Sjögren's Syndrome -- Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjögren's Syndrome -- The Neurological Manifestations of Sjögren's Syndrome: Diagnosis and Treatment -- New Approaches for the Management of Dry Mouth in Sjögren's Syndrome in Japan -- New Approaches for the Management of Dry Mouth and Dry Eye in Sjögren's Syndrome in Japan Dry Eye Part -- Sjögren's Syndrome in Australia: Clinical Practice and Research -- Primary Sjögren's Syndrome: Report from India -- Sjögren's Syndrome in China -- Sjögren's Syndrome in China -- Sjögren's Syndrome in Israel: A Scientific Point of View -- Looking into the Future-The EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjögren's Syndrome -- Looking into the Crystal Ball: Initiatives from the Sjögren's Syndrome Foundation That Will Impact Patient Care -- Biological Treatment for Sjögren's Syndrome -- Looking into the Future-Emerging Therapies Based on Pathogenesis -- Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy.
  • Sjögren's Syndrome is slowly being recognised as one of the most common auto-immune diseases, and considered pivotal in the spectrum of auto-immune disorders. Sjögren's Syndrome in Clinical Practice is a unique, concise book which explores important insights into Sjögren's links with other conditions and devotes itself to shedding new light on this disease. Aimed at young medics but also suitable for the informed lay reader, physicians and pharma, Sjögren's Syndrome in Clinical Practice will help with the diagnosis and treatment of this increasingly recognised disorder.
  • Skeletal examination method -- Skull fractures -- Rib fractures -- Fractures of the vertebral column, sternum, scapulae, and clavicles -- Long bone fractures -- Healing and interpretation -- Natural disease may mimic child abuse.
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    Approach to trauma -- Trauma in adults : upper extremity -- Trauma in adults : axial skeleton -- Trauma in adults : lower extremity -- Trauma in children -- Imaging of fracture treatment and healing -- Approach to bone lesions -- Malignant and aggressive tumors -- Benign lesions -- Metastatic tumors -- Approach to joint disease -- Inflammatory arthritis -- Noninflammatory joint disease -- Developmental and congenital conditions -- Metabolic and systemic conditions -- Infection and marrow disease -- Postsurgical imaging.
  • An Epidemiological approach to forensic investigations of violations to international humanitarian and human rights law -- Differential diagnosis of skeletal trauma -- Blasting injuries -- Blunt force trauma -- Skeletal evidence of torture -- Sharp force trauma -- Gunfire injuries -- Variation in gunfire wounds by skeletal region.
  • The history of fracture treatment -- Global burden of musculoskeletal injuries -- The challenges of orthopaedic trauma care in the developing world -- Biology and enhancement of skeletal repair -- Biomechanics of fractures -- Closed fracture management -- Principles and complications of external skeletal fixation -- Principles of internal fixation -- Evaluation and treatment of the multi-injured trauma patient -- Initial evaluation of the spine in trauma patients -- Damage control orthopaedic surgery : a strategy for the orthopaedic care of the critically injured patient -- Disaster management -- Occupational hazards in the treatment of orthopaedic trauma -- Medical management of the orthopaedic trauma patient -- Evaluation and treatment of vascular injuries -- Compartment syndromes -- Open fractures -- Soft tissue reconstruction -- Gunshot wounds and blast injuries -- Pathologic fractures -- Osteoporotic fragility fractures -- Surgical site infection prevention -- Diagnosis and treatment of complications -- Chronic osteomyelitis -- Nonunions : evaluation and treatment -- Physical impairment ratings for fractures -- Outcome assessment in orthopaedic traumatology -- Professionalism and the economics of orthopaedic trauma care -- Psychological, social, and functional manifestations of orthopaedic trauma and traumatic brain injury * -- Imaging of spinal trauma -- Pathophysiology and emergent treatment of spinal cord injury -- The timing of management of spinal cord injuries -- Craniocervical injuries -- Subaxial cervical spine trauma -- Thoracolumbar fractures -- Fractures in the ankylosed spine -- Osteoporotic spinal fractures -- Avoiding complications in spine trauma patients -- Principles of orthotic management -- Pelvic ring injuries -- Surgical treatment of acetabular fractures -- Fractures and dislocations of the hand -- Fractures and dislocations of the carpus -- Fractures of the distal radius -- Diaphyseal fractures of the forearm -- Trauma to the adult elbow and fractures of the distal humerus -- Fracture of the humeral shaft -- Proximal humerus fractures and glenohumeral dislocations -- Fractures and dislocations of the clavicle -- Scapula and rib fractures -- Replantation -- Hip dislocations -- Medical management of the patient with hip fracture -- Intracapsular hip fractures -- Intertrochanteric hip fractures -- Posttraumatic reconstruction of the hip joint -- Subtrochanteric fractures of the femur -- Femoral shaft fractures -- Fractures of the distal femur -- Patella fractures and extensor mechanism injuries -- Knee dislocations and soft tissue injuries -- Tibial plateau fractures -- Malunions and nonunions about the knee -- Tibial shaft fractures -- Fractures of the tibial pilon -- Malleolar fractures and soft tissue injuries of the ankle -- Foot injuries -- Posttraumatic reconstruction of the foot and ankle -- Periprosthetic fractures of the lower extremity -- Principles of deformity correction -- Limb salvage and reconstruction -- Amputations in trauma.
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    v. 1. General principles, spine, pelvis -- v. 2. Upper extremity, lower extremity.
  • Skeletal growth, development, and healing as related to pediatric trauma / Stephen L. Frick, Eric T. Jones -- Physeal injuries / Manoj Ramachandran, David L. Skaggs -- Pathologic fractures in children / Herbert S. Schwartz, Ginger E. Holt -- The multiply injured child / John H. Wilber, George H. Thompson, Jochen Son-Hing -- Fractures with soft tissue injuries / Sanjeev Sabharwal, Fred F. Behrens -- Complications of fractures in children / Robert N. Hensinger -- Outcomes assessment in children with fractures / James G. Wright, Nancy L. Young -- Fractures and dislocations of the forearm, wrist, and hand / Martin Dolan, Peter M. Waters -- Fractures and dislocations about the elbow / Neil E. Green, Nathan L. Van Zeeland -- Fractures and dislocations about the shoulder / James F. Mooney III, Lawrence X. Webb -- Fractures of the spine / Gregory A. Mencio, Clinton J. Devin -- Fractures and dislocations about the hips and pelvis / Marc F. Swiontkowski -- Fractures of the femoral shaft / Jeffrey Shilt -- Fractures and dislocations about the knee / Lewis E. Zionts -- Fractures of the tibula and fibula / George H. Thompson, Jochen Son-Hing -- Fractures and dislocations of the foot and ankle / Alvin H. Crawford, Mohammed J. Al-Sayyad, Charles T. Mehlman -- Nonaccidental trauma / Jeffrey Shilt, Neil E. Green, Kathryn E. Cramer -- Anesthesia and analgesia for the ambulatory management of children's fractures / Eric C. McCarty, Gregory A. Mencio -- Rehabilitation of the child with multiple injuries / Louise Z. Spierre ... [et al.] -- Skeletal trauma in young adults / Kevin Shea, Eric W. Edmonds, Henry Chambers.
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    "What if what we consider to be reason-based, deliberative judgment is really the product of involuntary mental sensations? In A Skeptic's Guide to the Mind, Dr. Robert Burton takes a close look at the key false assumptions that permeate the field of cognitive science and offers a new way of exploring how our brains generate thought. The essential paradox that drives this cutting-edge theory is that the same mechanisms that prevent understanding the mind also generate a sense that we can attain such understanding. In A Skeptic's Guide to the Mind, Burton presents his theory of the 'mental sensory system'--a system that generates the main components of consciousness: a sense of self, a sense of choice and free will, and how we make moral decisions. Bringing together anecdotes, practical thought experiments, and cutting-edge neuroscience to show how these various strands of thought and mental sensations interact, A Skeptic's Guide to the Mind offers a powerful tool for knowing what we can and cannot say about the mind; how to discern good from bad cognitive science studies; and most importantly, how to consider the moral implications of these studies. This is a pathbreaking model for considering the interaction between conscious and unconscious thought."-- Provided by publisher.
  • Contributors -- Foreword -- pt. 1. Wound care and prevention -- 1. Skin care and wound prevention strategies -- 2. Assessing and documenting chronic wounds -- 3. Types of chronic wounds -- 4. Laboratory values in chronic wound management -- 5. Developing a skin and wound care formulary -- 6. Tissue load management -- 7. Wound care and the regulatory process -- pt. 2. Skin and wound care products -- Skin care products -- Overview -- Antifungals and antimicrobials -- Liquid skin protectants -- Moisture barriers -- Skin cleansers -- Therapeutic moisturizers -- Wound care products -- Dressings and devices -- Overview -- Alginates -- Antimicrobials -- Collagens -- Composites -- Color illustrations -- Contact layers -- Foams -- Hydrocolloids -- Hydrogels -- Specialty absorptives -- Surgical supplies, miscellaneous -- Transparent films -- Wound fillers -- Other products -- Drugs -- Overview -- Products -- pt. 3. Additional dressings and products -- Overview -- Abdominal dressing holders and binders -- Compression bandage systems -- Conforming bandages -- Elastic bandage rolls -- Gauze, impregnated with other than water, normal saline, or hydrogel, without adhesive border -- Gauze, impregnated with water or normal saline, without adhesive border -- Gauze, nonimpregnated, with adhesive border -- Gauze, nonimpregnated, without adhesive border -- Tapes -- Wound cleansers -- Appendices -- A. Body mass index -- B. Wagner ulcer grade classification -- C. Braden scale -- D. Treatment algorithm for pressure ulcers -- E. Treatment algorithm for arterial ulcers -- F. Treatment algorithm for venous ulcers -- G. Treatment algorithm for diabetic ulcers -- H. Treatment algorithm for diabetic ulcer wound care -- I. Laboratory tests to rule out atypical causes of leg ulcers -- J. Ankle-brachial index use in patients with diabetes -- Manufacturer resource guide -- Selected references -- Index.
  • Skin aging 2006
    Also available: Print – 2006
    1. Recent Demographic Changes and Consequences for Dermatology / Ursula Krämer and Tamara Schikowski, p. 1-8 -- 2. Clinical and Histological Features of Intrinsic versus Extrinsic Skin Aging / Mina Yaar, p. 9-21 -- 3. Ethnic Differences in Skin Aging / Erwin Tschachler and Frederique Morizot, p. 23-31 -- 4. Photoaging of Skin / Jean Krutmann and Barbara Gilchrest, p. 33-43 -- 5. Premature Skin Aging by Infrared Radiation, Tobacco Smoke and Ozone / Peter Schroeder, Stefan Schieke and Akimichi Morita, p. 45-53 -- 6. The Role of Hormones in Intrinsic Aging / Christos Zouboulis and Evgenia Makrantonaki, p. 55-64 -- 7. Permeability and Antioxidant Barriers in Aged Epidermis / Jens Thiele, Chantal Barland, Ruby Ghadially and Peter Elias, p. 65-79 -- 8. Clarifying the Vitamin D Controversy: The Health Benefits of Supplementation by Diet Versus Sunshine / Deon Wolpowitz and Barbara Gilchrest, p. 81-102 -- 9. Modern Photoprotection of Human Skin / Jean Krutmann and Daniel Yarosh, p. 103-112 -- 10. Vitamins and Polyphenols in Systemic Photoprotection / Wilhelm Stahl, Hasan Mukhtar, Farrukh Afaq and Helmut Sies, p. 113-121 -- 11. Hormone Replacement Therapy and Skin Aging / Glenda Hall and Tania Phillips, p. 123-132 -- 12. Skin Aging in Three Dimensions / Niels Krejci-Papa and Robert Langdon, p. 133-142 -- 13. Retinoid Therapy for Photoaging / Laure Rittié, Gary Fisher and John Voorhees, p. 143-156 -- 14. Topical Photodynamic Therapy / Dany Touma and Rolf-Markus Szeimies, p. 157-166 -- 15. Botulinum Toxin, Fillers, Peels: The Scientific View / Nanna Schürer, p. 167-184 -- 16. Lasers / Roland Kaufmann and Christian Beier, p. 185-194.
  • 1. Structure and functionality of the skin / Ichiro Hatta -- 2. Response for external stimulation on the skin / Masaki Ujihara and Toyoko Imae -- 3. Beautification of the skin / Satoshi Amano, Tomonobu Ezure, and Toshii Iida -- 4. Skin bioscience : a molecular approach / Yoshimitsu Kuroyanagi.
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  • Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, dermatologists, general surgeons, and veterinary oncologists.
  • The dramatic increase in the incidence of skin cancers is a major concern worldwide and relates not only to melanoma but also to other cancers, including Merkel cell and basal cell carcinomas. Recently, the WHO has summarized the genetic and pathologic features of skin cancers in its book series. However, the WHO's proposed classification of certain disease entities, such as basal cell carcinomas, is still novel for many dermatologists. This book covers the entire spectrum of cutaneous malignancies in accordance with the new WHO classification. Epidemiology, pathogenesis, diagnosis, and therapy are all reviewed in detail, and care is taken to link the diagnostic and genetic features to optimized therapeutic strategies.-- Provided by publisher.
  • Also available: Print – 2009
  • Biopsy techniques and interpretation / Deborah F. MacFarlane and Ronald P. Rapini -- Topical therapies for nonmelanoma skin cancers / Abel Torres and Tejas Desai -- Chemical peels for precancerous skin lesions / Gary D. Monheit and Chad L. Prather -- Photodynamic therapy / Nathalie C. Zeitouni, Allan Oseroff, and David J. Najarian -- Intralesional and perilesional treatment of skin cancers / Christopher J. Arpey, Nicole M. Annest, Stephen B. Tucker, Ronald P. Rapini, and Deborah F. MacFarlane -- Electrodesiccation and curettage / Gloria F. Graham -- Cryosurgery / Gloria F. Graham -- Optimizing surgical outcomes / Thomas Stasko and Amy Ross -- Anesthesia / Susannah L. Collier and George J. Hruza -- Excision techniques, staples, and sutures / Mollie A. MacCormack -- Mohs surgery / Desiree Ratner and Jennifer L. MacGregor -- Cutaneous flaps / Tatyana Humphreys -- Techniques in skin grafting / Deborah F. MacFarlane -- Nail surgery and malignant tumors of the nail unit / Deborah F. MacFarlane and Richard K. Scher -- Practical management of melanoma / Mark F. Naylor -- Skin cancer in skin of color / Brooke A. Jackson -- Management of skin cancers in solid organ transplant recipients / John Carucci and Dariush Moussai -- Imaging of head and neck skin cancer / Komal Shah, Jane Onufer, and Deborah F. MacFarlane -- Radiation oncology in skin cancer treatment / Susan L. McGovern and Matthew T. Ballo -- When to refer out / Daniel M. Siegel, Laura T. Cepeda, and Deborah F. MacFarlane -- Chemoprevention of skin cancer / Fiona Zwald and David Lambert.
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  • Print Material
  • Also available: Print – 2011
  • As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases. The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects. Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.
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  • Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.
  • An era of global population aging is upon us. By 2030, one in eight people will be over age 65. Since women generally live longer than men, the health and welfare of postmenopausal women will become a significant public health concern. This book offers a comprehensive review of the life changes associated with menopause, both at the dermatological and physiological level (e.g., hormonal, immunological) and at the subcellular level. It critically examines the dermatological, biological, and clinical challenges to postmenopausal health and well-being and the current and emerging therapeutic interventions. The authors advocate a holistic approach, emphasizing the need to view the menopause as a life transition with various facets rather than as a series of distinct medical conditions to be managed. Our goal is to offer a comprehensive resource to the researchers, clinicians, physicians, and helping professions whose mission is to promote the health and well-being of women around the world.
  • Skin necrosis 2015
    In recent years, wound care has gained increasing recognition as a distinct medical specialty. An understanding of the complex mechanisms involved in wound healing facilitates efficient assessment and treatment of patients with wounds, and skin necrosis can be considered the starting point in the entire healing process. This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. Richly illustrated, it primarily provides therapeutic strategies and treatment algorithms for different clinical contexts. All chapters were written by renowned specialists in their respected fields and include detailed sample cases and essential take-home messages. In light of the highly interdisciplinary nature of wound management, Skin Necrosis offers an invaluable resource for wound care practitioners and health care professionals across the fields of surgery, dermatology, internal medicine, and nursing.
  • This book serves as a practical guide to the diagnosis and treatment of common skin disorders in patients with skin of color. Emphasizing practical insights into diagnosis and treatment of skin and hair disorders in darker skinned patient populations, Skin of Color offers a detailed discussion of the nuances of treating skin of color. Topics of discussion include: management of acne, keloids, melasma, postinflammatory hyperpigmentation, acne keloidalis nuchae, alopecias, and the safe and effective use of chemical peels, laser procedures, and injectable fillers and toxins in skin of color patients.
  • Also available: Print – 2007
  • Also available: Print – 2008
  • Sleep and aging. 1st ed. 2005
    Also available: Print – 2005
  • Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences.
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  • GABA[subscript A] receptor subtypes in sedation and hypnosis / Esa R. Korpi -- Sleep hippocampal theta rhythm and sensory processing / Marisa Pedemonte and Ricardo A. Velluti -- Monoaminergic mechanisms in the regulation of sleep-wakefulness: special emphasis on preoptic noradrenergic system / Vijay Ramesh and Velayudhan Mohan Kumar -- REM sleep function and brain monoamine regulation: an application of the search activity concept / Vadim S. Rotenberg -- Role of wakefulness area in the brainstem reticular formation in regulating rapid eye movement sleep / Birendra N. Mallick ... [et al.] -- The mechanistic relationship between NREM sleep and anesthesia / Laura E. Nelson, Nicholas P. Franks, and Mervyn Maze -- Time-dependent psychotropic drug effects: hints of pharmacochronomics, broader than circadian time structures / Haruo Nagayama ... [et al.] -- Melatonin interaction with BZ-Gaba[subscript A] receptors: implications for sleep induction / Lennard P. Niles -- Melatonin: a chronobiotic that not only shifts rhythms / Dieter Kunz and Richard Mahlberg -- Melatonin and human sleep / Irina V. Zhdanova -- Melatonin efficacy to treat circadian alterations of sleep in Alzheimer's disease / Daniel P. Cardinali ... [et al.] -- Pharmacotherapy for seasonal affective disorder / Timo Partonen -- Use and discontinuation of hypnosedative medications / Mirko Petrovic -- Long-term use of sleeping pills in chronic insomnia / Milton Kramer -- Risks of chronic hypnotic use / Daniel F. Kripke -- Effects of psychotropics on driving performance / Henry J. Moller, Colin M. Shapiro, and Leonid Kayumov -- Diagnosis, pathophysiology and treatment of hypersomnias / Sebastiaan Overeem and Michel Billiard -- Chronic disease and sleep architecture pharmacotherapeutic considerations / James J. Herdegen -- Benzodiazepines for sedation in infants and children / Eugene Ng and Vibhuti Shah -- The pharmacological management of fatigue and sleepiness in affective disorders / Karl Doghramji -- Next-day residual effects of sleeping medications on driving ability: a review of the literature / Joris C. Verster, Marinus N. Verbaten, and Edmund R. Volkerts -- Sleep and pain / Wilfred R. Pigeon, Hyung Park, and Michael J. Sateia -- Head injuries and sleep / Chanth Seyone and Babita Kara -- Psychopharmacological management of restless legs syndrome and periodic limb movements in sleep / Raed Hawa ... [et al.] -- A comparison of visual analog scale and categorical ratings in assessing the patient's estimate of sleep quality / Nava Zisapel, Ricardo Tarrasch, and Moshe Laudon -- The pharmacostrategy of treating sleep disorders in Parkinsonism / Jean-Jacques Askenasy -- The neuropharmacology of nightmares / J.F. Pagel -- The night eating syndrome / Grethe Seta Birketvedt and Jon R. Florholmen -- Drug effects on dreaming / Mehmet Yucel Agargun and Hanefi Ozbek -- Sleep problems in primary care / Alan G. Wade -- SSRIs and sleep in man / Sue J. Wilson and David J. Nutt -- Sleep and antipsychotic drugs in schizophrenia patients / Jaime M. Monti and Daniel Monti -- Sleep and epilepsy: from interrelationships to influence of antiepileptic drugs / Antonio Martins da Silva ... [et all.] -- Herbal medicines and sleep / Marcello Spinella.
  • Also available: Print – 2006
    Electrical stimulation of the upper airways muscles / Randerath, W.J. -- Cardiac pacemaker therapy in sleep apnea / Schichtl, T., Pfeifer, M. -- Surgical treatment for obstructive sleep apnea / Boudewyns, A.N., Van de Heyning, P.H. -- Alternative therapies for obstructive sleep apnea syndrome : behavioral and pharmacological options / Smith, I.E. -- Central sleep apnea, hypoventilation syndromes, and periodic breathing disorders / Caples, S.M., Somers, V.K. -- Cardiovascular complications of sleep-related breathing disorders / Naughton, M.T., Sanner, B.M. -- Sleep-related breathing disorders in children / Amin, R.S. ... [et al.] -- Sleep-related breathing disorders in the elderly / Cooke, J.R., Ancoli-Israel, S. -- Sleep-disordered breathing in pregnancy / Sullivan, C.E., Edwards, N. Obstructive sleep apnea-hypopnea syndrome definitions of pathophysiology / De Backer, W. -- Oxidative stress--the culprit of obstructive sleep apnea syndrome / Lavie, L., Lavie, P. -- Genetics aspects of the obstructive sleep apnea/hypopnea syndrome / Riha, R.L. -- Upper airway muscles in obstructive respiratory sleep disorders / Svanborg, E. -- Obstructive sleep apnea : clinical presentation, diagnosis, and treatment / Yim, S., Jordan, A., Malhotra, A. -- Automatic positive airway pressure titration and treatment / Randerath, W.J. -- Treatment humidification in sleep-related breathing disorders / Benjafield, A.V., Richards, G.N. -- Oral appliances in the treatment of obstructive sleep apnea and snoring / Marklund, M. Sleep disorders and their classification--an overview / Lévy, P., Viot-Blanc, V., Pépin, J.-L -- Physiology of sleep and dreaming / Penzel, T., Kesper, K. -- Physiology of breathing during sleep / Schäfer, T. -- Physiology of the cardiovascular, endocrine, and renal systems during sleep / Peter, J.G., Fietze, I. -- History and questionnaires / Rühle K.-H. -- Objectifying sleepiness / Hein, H. -- Portable monitoring systems / Hein, H. -- Polysomnography / Penzel, T. -- Nasal, lung, and cardiovascular function tests / Galetke, W. -- Upper airway imaging in sleep apnea syndrome / Pinto Basto, R., Rodenstein, D.O. -- Upper airway obstruction in snoring and upper airway resistance syndrome / Kirkness, J.P. ... [et al.].
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    Diurnal molecular rhythms : unrecognized critical determinants of cardiovascular health and disease / Michael J. Sole and Tami A. Martino -- Lower brainstem mechanisms of cardiorespiratory integration / Patrice G. Guyenet -- Mechanical interactions between the respiratory and circulatory systems / Sheldon Magder -- Respiratory and cardiac activity during sleep onset / John Trinder and Christian L. Nicholas -- Physiological effects of sleep on the cardiovascular system / Richard L. Horner -- Sleep apnea and alterations in glucose metabolism / Naresh M. Punjabi -- Oxidative stress, inflammation, and vascular function in obstructive sleep apnea syndrome / John Garvey ... [et al.] -- Obesity, sleep apnea, and the cardiorespiratory effects of leptin / Kenneth R. McGaffin and Christopher P. O'Donnell -- Influence of sleep and sleep apnea on autonomic control of the cardiovascular system / Krzystof Narkiewicz -- Epidemiological evidence for an association between sleep apnea, hypertension and cardiovascular disease / Yamini S. Levitzky and Susan Redline -- Treatment of hypertension in sleep apnea / Oded Friedman and Alexander G. Logan -- Sleep apnea and cardiac arrhythmias / Richard S.T. Leung and Clodagh M. Ryan -- Obstructive sleep apnea and atherosclerosis / Geraldo Lorenzi-Filho and Luciano F. Drager -- Sleep apnea and stroke / Massimiliano M. Siccoli and Claudio L. Bassetti -- Circadian rhythm of cardiac and cerebrovascular ischemic events / Dan Sprajja and Apoor S. Gami -- Quantitative models of periodic breathing and Cheyne-Stokes respiration / Michael C.K. Khoo -- Pathophysiological interactions between sleep apnea and heart failure / Dai Yamino, John S. Floras, and T. Douglas Bradley -- Prevalence and prognostic significance of obstructive and central sleep apnea in heart failure / Paula A. Lanfranchi -- Treatment of obstructive and central sleep apnea in patients with heart failure / Matthew T. Naughton and Michael Arzt.
  • A multi-disciplinary approach that covers both the surgical and non-surgical interventions for sleep apnea and snoring. Full-color line drawings illustrate key concepts and create a comprehensive way of learning surgical techniques. Provides quick, easy access to the most up-to-date surgical and non surgical interventions for sleep apnea and snoring. Includes contributions from leaders in neurology, pulmonology, psychiatry, otolaryngology, and oral & maxillofacial surgery. Covers new and innovative procedures including ZPP (Zeta palatopharyngoplasty), Transpalatal Advancement Pharyngoplasty and Minimally invasive submucosal glossectomy. Details when and why surgery is necessary, and how to perform a successful operation for snoring and sleep apnea.
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    Perspectives / Wynne Chen and Clete A. Kushida -- History of sleep deprivation / William C. Dement, Clete A. Kushida, and Judy Chang -- Animal models of sleep deprivation / Joan C. Hendricks -- Sleep deprivation/fragmentation paradigms. Total sleep deprivation / Chiara Cirelli and Giulio Tononi. Partial and sleep-state selective deprivation / Carol A. Landis. Sleep fragmentation / Michael H. Bonnet -- Extrinsic factors affecting sleep loss/deprivation. Environmental influences on sleep and sleep deprivation / Kenneth P. Wright, Jr. Shift work / June J. Pilcher. Medications, drugs of abuse, and alcohol / Jonathan A.E. Fleming and Clete A. Kushida. Factors affecting test performance / Tracy F. Kuo and Clete A. Kushida -- Intrinsic factors affecting sleep loss/deprivation: cognitive, physiologic, and molecular associations. Attention and memory changes / Geneviève Forest and Roger Godbout. Cortical and electroencephalographic changes / Luca A. Finelli. Physiological and neurophysiological changes / Mahesh M. Thakkar and Robert W. McCarley. Metabolic and endocrine changes / Karine Spiegel, Rachel Leproult, and Eve Van Cauter. Thermoregulatory changes / Paul J. Shaw. Biochemical changes / Birendra N. Mallick, Vibha Madan, and Mohammad Faisal. Immunologic changes / Sarosh J. Motivala and Michael Irwin. Changes in gene expression / Chiara Cirelli. Criteria for classifying genes as sleep or wake genes / Priyattam J. Shiromani ... [et al.] -- Intrinsic factors affecting sleep loss/deprivation: psychiatric associations. Mood changes / Camellia P. Clark. Antidepressant effects / Joseph C. Wu ... [et al.] Personality/psychopathologic changes / Camellia P. Clark, J. Christian Gillin, and Barbara L. Parry -- Other intrinsic factors affecting sleep loss/deprivation. Age and individual determinants of sleep loss effects / Hélène Gaudreau, Julie Carrier, and Bwanga-Mukishi Tchiteya. Homeostatic and circadian influences / Joel H. Benington.
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  • The cognitive and behavioral implications of sleep deprivation have been noted in the medical literature for many years. In addition, emerging research continues to demonstrate the contribution of sleep deprivation to some of the most common and costly health conditions today. Sleep Deprivation and Disease provides clinically relevant scientific information to help clinicians, public health professionals, and researchers recognize the ramifications of sleep deprivation across a broad spectrum of health topics. This timely reference covers sleep physiology, experimental approaches to sleep deprivation and measurement of its consequences, as well as health and operational consequences of sleep deprivation. Clinical challenges and areas of uncertainty are also presented in order to encourage future advancements in sleep medicine and help patients avoid the outcomes associated with the myriad causes of sleep deprivation.
  • Part 1. The Normal Upper Airway -- Upper Airway Structure During Development / Seung Hoon Lee -- Functional Aspects and Upper Airway Control During Wakefulness and Sleep / Neriel Katz, Tamar Etzioni and Giora Pillar -- Lymphadenoid Tissues in the Upper Airway / Jinkwan Kim and David Gozal -- The Nasal Airway / Fuad M. Baroody -- Part 2. Sleep During Development -- Neural Mechanisms of Sleep and Circadian Rhythms / Edgar Garcia-Rill -- EEG and Sleep During Development / Raffaele Ferri, Luana Novelli and Oliviero Bruni -- Autonomic Cardiovascular Regulation During Sleep / Anna Vlahandonis, Lisa M. Walter, Stephanie R. Yiallourou and Rosemary S.C. Horne -- Arousal: Ontology, Functional Anatomy, Methodology, and Consequences / Eliot S. Katz -- Metabolic and Hormonal Regulation During Sleep / Riva Tauman -- Chemoreceptors, Breathing, and Sleep / John L. Carroll, Supriya K. Jambhekar and David F. Donnelly -- Pathophysiology of Pediatric Obstructive Sleep Apnea: Putting It All Together / Eliot S. Katz -- Part 3. Diagnostic Assessment of Sleep and Breathing in Children -- Clinical Evaluation of the Pediatric Patient / Hari P.R. Bandla -- Actigraphy / Hawley E. Montgomery-Downs and Lisa J. Meltzer -- Abbreviated/Portable Recordings / Luigi Ferini-Strambi -- Overnight Sleep Study and MSLT / Jyoti Krishna -- Upper Airway Imaging in Children with Obstructive Sleep Apnea Syndrome / Raanan Arens and Sanghun Sin -- The "Omics" Future: Genomics, Transcriptomics, and Proteomics / Sina A. Gharib -- Pediatric Sleep-Disordered Breathing: Criteria and Spectrum of Disease / Karen Spruyt -- Part 4. SDB in Children -- Apnea of Prematurity / Christian F. Poets -- Epidemiologic Aspects of Pediatric OSA Around the World / Athanasios Kaditis -- Obesity and Sleep / Edward O. Bixler, Alexandros N. Vgontzas, Marina Tsaoussoglou and Susan L. Calhoun -- Obstructive Sleep Apnea in Children with Down Syndrome / Dennis Rosen -- Children with Neuromuscular Disorders / Aviv D. Goldbart -- Sleep Problems in Children with Sickle Cell Disease / Umakanth Khatwa, Alia Bazzy-Asaad and Sanjeev V. Kothare -- Children with Craniofacial Syndromes / Wendy Estrellado-Cruz and Robert C. Beckerman -- Epilepsy, Headache, and Sleep-Disordered Breathing / Martina Vendrame and Sanjeev V. Kothare -- Sleep and Breathing in Cystic Fibrosis / Amanda J. Piper -- Asthma and Obstructive Sleep Apnea / Leila Kheirandish-Gozal -- Central Hypoventilation Syndromes / Iris A. Perez, Thomas G. Keens and Sally L. Davidson Ward -- Health-Care Utilization and Pediatric Obstructive Sleep Apnea / Ariel Tarasiuk and Haim Reuveni -- Gastroesophageal Reflux and Sleep-Disordered Breathing / Hari P.R. Bandla and Aparna R. Rao -- Part 5. Consequences of SDB in Children -- Behavioral Morbidity in Pediatric Sleep-Disordered Breathing / Elise K. Hodges, Barbara True Felt, Bruno J. Giordani and Ronald D. Chervin -- Neurocognitive Function and Learning in Children with Sleep-Disordered Breathing / Karen Spruyt -- Brain Regulatory Mechanisms Underlying Breathing: Insights for Sleep Pathology / Ronald M. Harper, Rajesh Kumar, Paul M. Macey, Jennifer A. Ogren and Mary A. Woo -- Cardiovascular Implications / Rakesh Bhattacharjee and Leila Kheirandish-Gozal -- Metabolic Consequences of Sleep Disorders / David Gozal -- Enuresis and Obstructive Sleep Apnea in Children / Oscar Sans Capdevila and Maria Eugenia Russi Delfraro -- Part 6. Treatment of SDB -- Adenotonsillectomy / Rakesh Bhattacharjee -- Corticosteroids and Leukotriene Modifiers in Pediatric SDB / Aviv D. Goldbart and Leila Kheirandish-Gozal -- CPAP Treatment in Children / Dafna Ofer and Carole L. Marcus -- Mandibular Advancement Devices / Maria Pia Villa and Silvia Miano -- Diaphragmatic Pacing in Infants and Children with Congenital Central Hypoventilation Syndrome / Anthony C. Chin, Donald B. Shaul, Pallavi P. Patwari, Thomas G. Keens and Anna S. Kenny, et al.
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    Concept of sleep medicine and of neurosomnology / Antonio Culebras -- Disorders of development and maturation of sleep / Stephen H. Sheldon -- Sleep disorders associated with mental retardation / Michael J. Rack -- Insomnia in neurology / Federica Provini, Carolina Lombardi, and Elio Lugaresi -- Delayed sleep phase disorder and other circadian rhythm sleep disorders / Baruch El-Ad -- Narcolepsy / Claudio L. Bassetti -- Secondary narcolepsy / Thomas E. Scammell -- Hypocretin, hypothalamic system / Christian R. Baumann and Claudio L. Bassetti -- Idiopathic hypersomnia and recurrent hypersomnia / Douglas B. Kirsch and Ronald D. Chervin -- Motor disorders of sleep: periodic, aperiodic, and rhythmic motor disorders / Roberto Vetrugno and Pasquale Montagna -- Restless legs syndrome / Renata Egatz, Belen Cabrero, and Diego Garcia-Borreguero -- Periodic leg movements of sleep / Diego Garcia-Borreguero, Oscar Larrosa, and Renata Egatz -- Sleep in Parkinson's disease / Robert L. Rodnitzky -- Epilepsy and sleep / Bradley V. Vaughn and O'Neill F. D'Cruz -- Somnambulism, somniloquy, and sleep terrors / Rosalia Silvestri -- Rapid eye movement sleep behavior disorder / Mark W. Mahowald and Carlos H. Schenck -- Obstructive and nonobstructive sleep apnea: the neurological perspective / Gulcin Benbir and Christian Guilleminault -- Sleep apnea and stroke / Antonio Culebras -- Sleep disturbances in dementia and other neurodegenerative -- disorders / Alon Y. Avidan -- Autonomic dysfunctions in sleep disorders / Pietro Cortelli and Carolina Lombardi -- Headache disorders and sleep / Antonio Culebras -- Sleep in traumatic brain injury and other acquired central nervous system conditions / Mark W. Mahowald -- Sleep disorders associated with multiple sclerosis / Antonio Culebras -- Sleep disorders and neuromuscular disorders / Antonio Culebras --Stimulant-dependent and hypnotic-dependent sleep disorders / Harold R. Smith.
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  • Sleep physiology -- Extent and health consequences of chronic sleep loss and sleep disorders -- Functional and economic impact of sleep loss and sleep-related disorders -- Improving awareness, diagnosis, and treatment of sleep disorders -- Ensuring adequate diagnosis and treatment : access, capacity, and technology development -- Opportunities to improve career development in somnology -- Bolstering somnology and sleep disorders research programs -- Building sleep programs in academic health centers.
  • Also available: Print – 2006
    Introduction / Hrayr P. Attarian -- Epidemiology of sleep disorders in women / Hrayr P. Attarian -- Workup of female patients with sleep complaints: a guide for mid-level health care providers / Diana Monaghan -- The impact of life cycle on sleep in women / Margaret Moline, Lauren Broch, and Rochelle Zak -- Normal reproductive and endocrine life stages and their impact on different sleep disorders / Rochelle Goldberg -- Delayed sleep phase syndrome in adolescents / John Garcia -- Defining, assessing, and treating adolescent insomnia and related sleep problems / Amy R. Wolfson, Alison Quinn, and Anna Vannucci -- Restless legs syndrome: an overview with an emphasis on women / David M. Hiestand and Barbara Phillips -- Nonhormonal treatments for insomnia / Catherine C. Schuman -- Obstructive sleep apnea-hypopnea syndrome in premenopausal women / Kanika Bagai and Beth A. Malow -- Polycystic ovary syndrome and obstructive sleep apnea / Mira Aubuchon -- Women and excessive daytime sleepiness / Hrayr P. Attarian -- Parasomnias from a woman's health perspective / Carlos H. Schenck and Mark W. Mahowald -- Restless legs syndrome in pregnancy / Keith J. Nagle -- Evaluating insomnia during pregnancy and postpartum / Katherine A. Lee and Aaron B. Caughey -- Pregnancy and obstructive sleep apnea / Helena Schotland -- Restless legs syndrome and menopause / Nancy S. Collins -- Insomnia during menopause: sleep laboratory studies on insomnia associated with postmenopausal syndrome and hormone replacement therapy / Gerda Saletu-Zyhlarz ... [et al.] -- Obstructive sleep apnea and menopause / Grace Pien and Sigrid Veasey.
  • In Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition, a multidisciplinary panel of eminent researchers and practicing clinicians comprehensively updates the multifaceted aspects of sleep disorders in women at different stages of life, illuminating the unique impact that each reproductive and endocrine stage has on both normal sleep and sleep disorders. This title not only introduces primary care physicians and health care providers to the discipline of sleep disorders in women, it also will appeal to a broader set of specialists as it summarizes the latest, cutting-edge research and presents it in a succinct and clinically relevant manner. The goal of this book is to help physicians recognize the symptom patterns of sleep disorders in their female patients, guide them in diagnosing and treating these patients in a timely fashion, and help in the elimination of gender bias in sleep medicine research and care. An invaluable addition to the literature, Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition again fills an important niche by being an accessible, comprehensive, multidisciplinary review on sleep disorders in women.
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    Introduction / William C. Dement -- An overview of normal sleep / Sudhansu Chokroverty -- Sleep deprivation and sleepiness / Sudhansu Chokroverty -- Neurobiology of rapid eye movement and non-rapid eye movement sleep / Robert W. McCarley -- Neurophysiologic mechanisms of slow-wave (non-rapid eye movement) sleep / Mircea Steriade -- Neurotransmitters, neurochemistry, and the clinical pharmacology of sleep / Max Hirshkowitz, Mary Wilcox Rose and Amir Sharafkhaneh -- Physiologic changes in sleep / Sudhansu Chokroverty -- Circadian timing and sleep-wake regulation / Robert Y. Moore -- Sleep and memory consolidation / Matthew P. Walker and Robert Stickgold -- Dreaming in sleep-disordered patients / Rosalind Cartwright -- Polysomnographic technique : an overview / Sharon A. Keenan -- Electroencephalography, electromyography, and electro-oculography : general principles and basic technology / Thaddeus S. Walczak and Sudhansu Chokroverty -- Electrocardiographic technology of cardiac arrhythmias / Daniel M. Shindler and John B. Kostis -- Evaluation and monitoring of respiratory function / Reena Meara and Kingman P. Strohl -- Neuroimaging in sleep and sleep disorders / Martin Desseilles ... [et al.] -- Measurement of sleepiness and alertness : multiple sleep latency test / Thomas Roth and Timothy A. Roehrs -- The maintenance of wakefulness test / Karl Doghramji -- Clinical polysomnography and the evolution of recording and scoring technique / Max Hirshkowitz and Amir Sharafkhaneh -- Approach to the patient with sleep complaints / Sudhansu Chokroverty -- Classification of sleep disorders / Michael J. Thorpy -- Epidemiology of sleep disorders / Maurice Moyses Ohayon and Christian Guilleminault -- Human and animal genetics of sleep and sleep disorders / Stéphanie Maret, Yves Dauvilliers, and Mehdi Tafti -- Nutrition and sleep / Markku Partinen -- Obstructive sleep apnea syndrome / Christian Guilleminault and Michael Zupancic -- Positive airway pressure in the treatment of sleep apnea-hypopnea / Mark H. Sanders ... [et al.] -- Nature and treatment of insomnia / Charles M. Morin and Ruth M. Benca -- Narcolepsy / Christian Guilleminault and Vivien C. Abad -- Motor functions and dysfunctions of sleep / Wayne A. Hening ... [et al.] -- Sleep, breathing, and neurologic disorders / Sudhansu Chokroverty and Pasquale Montagna -- Sleep and epilepsy / Sudhansu Chokroverty and Pasquale Montagna -- Dreaming in neurologic disorders / Mark Solms and Susan Malcolm-Smith -- Sleep in psychiatric disorders / Peter L. Franzen and Daniel J. Buysse -- Sleep disturbances in general medical disorders / Sudhansu Chokroverty -- Circadian rhythm disorders / Mark W. Mahowald and Milton G. Ettinger -- Parasomnias / Jacques Montplaisir ... [et al.] -- Sleep disorders in the elderly / Sudhansu Chokroverty -- Sleep disorders of childhood / Richard Ferber -- Evolution of sleep from birth through adolescence, and sleep-disordered breathing in children / Timothy F. Hoban -- Women's sleep / Helen S. Driver and Eileen P. Sloan -- Sleep-related violence : forensic medicine issues / Mark W. Mahowald and Carlos H. Schenck.
  • Sleep disorders. Part I-II pt. 1-2, 2011.
    pt. 2, 2011 ScienceDirect
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  • Circadian Clock Genes and the Regulation of Sleep / Thomas Curie and Paul Franken -- Clock Genes and Energy Metabolism / Hee-Kyung Hong, Wenyu Huang, Kathryn Moynihan Ramsey, Biliana Marcheva and Joseph Bass -- Neural Circuitry Responsible for Sleep and Wakefulness / Roda Rani Konadhode, Dheeraj Pelluru and Priyattam J. Shiromani -- Feeding as a Reward Mechanism / Ralph J. DiLeone, Nandakumar S. Narayanan and Douglas J. Guarnieri -- Plasticity of Brain Feeding Circuits in Response to Food / Tamas Horvath -- The Neurogenetics of Energy Balance / Martin G. Myers Jr. -- Short Sleep and Obesity Risk in Children / Chantelle N. Hart, Elizabeth S. Kuhl and Elissa Jelalian -- Circadian Misalignment and Sleep Disruption in Shift Work: Implications for Fatigue and Risk of Weight Gain and Obesity / Rachel R. Markwald and Kenneth P. Wright Jr. -- Sleep Apnea and Obesity / Vidya Krishnan and Sanjay R. Patel -- The Connection Between Sleep Loss, Obesity, and Type 2 Diabetes / Silvana Pannain, Guglielmo Beccuti and Eve Van Cauter -- Sleep Disturbances: Impact on Risk and Severity of Diabetes / Kelly A. Holes-Lewis -- Insufficient Sleep and Cardiovascular Disease / Susan Redline -- Clinical Guidelines for the Evaluation of Adults with Obstructive Sleep Apnea / Lawrence J. Epstein -- Pharmacological Treatment of Obesity / Dhiraj G. Kabra, Uma D. Kabra, Matthias H. Tschöp and Susanna Hofmann -- Bariatric Surgery for Treatment of Obesity / Mark J. Perna, Thomas Karl Byrne and Chitharanja C. Pullattrana.
  • A new addition to the Neurology in Practice series, Sleep Medicine in Neurology is a practical guide for neurologists diagnosing and managing sleep disorders in their patients. As a part of the series, various feature boxes are highlighted throughout. ""Tips and Tricks"" give suggestions on how to improve outcomes through practical technique or patient questioning. In addition, ""Caution"" warning boxes supply helpful advice on how to avoid problems and 'Science Revisited' boxes offer quick reminders of the basic science principles necessary for understanding the presented concepts.
  • Behavioral and electrophysiological correlates of sleep and sleep homeostasis -- Genetic dissection of sleep homeostasis -- Sleep deprivation and gene expression -- Sleep and synaptic homeostasis -- Sleep and synaptic plasticity in the developing and adult brain -- Sleep and adult neurogenesis: implications for cognition and mood -- Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms -- A bird's eye view of sleep-dependent memory consolidation -- Neuroimaging studies of sleep and memory in humans -- The role of sleep in human declarative memory consolidation -- Sleep-dependent memory consolidation in healthy aging and mild cognitive impairment -- Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics -- Optogenetic control of hypocretin (orexin) neurons and arousal circuits -- Stress, arousal, and sleep -- Sleep and emotional functions -- Sleep and plasticity in schizophrenia -- Chronically restricted or disrupted sleep as a casula factor in the development of depression -- Sleep deprivation therapy for depression -- Pharmacological treatment of sleep disorders and its relationship with neuroplasticity -- Index.
  • "Human Impact Assessment (HuIA) is a relatively new concept describing an integrated process that encompasses both Health Impact Assessment and Social Impact Assessment and is used to anticipate the effects of programs, projects and decisions on human health and welfare. Sleep occupies approximately one-third of our lives, but its human impact remains largely unrecognized. The prevalence of excessive sleepiness is recognized to be increasing in industrialized societies. Sleepiness and fatigue have high costs in terms of both lives lost and socioeconomic impact. Sleepiness and Human Impact Assessment provides a comprehensive exploration of many different facets of sleepiness in our 24-hour society from the new HuIA point of view. Among the covered issues are the physiology and pathophysiology of sleep, its relationship to daytime alertness, fatigue and drugs, the relevance of sleep-related fatigue in various occupational settings and public safety. This book will be of assistance to physicians, occupational health professionals, ergonomists, researchers and decision-makers as they strive to understand the full significance of sleepiness and to create a culture of accountability in everyday life without sleep-related risks."--Publisher's website.
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  • V. 1: -- Sect. I: Biology of the gastrointestinal tract -- Sect. II: Nutrition in gastroenterology -- Sect. III: Symptoms, signs, and biopsychosocial issues -- Sect. IV: Topics involving multiple organs -- Sect. V: Esophagus -- Sect. VI: Stomach and duodenum -- Sect. VII: Pancreas -- Sect. VIII: Biliary tract -- V. 2: -- Sect. IX: Liver -- Sect. X: Small and large intestine -- Sect. XI: Additional treatments for patients with gastrointestinal and liver disease.
  • Also available: Print – 2005
  • In this book the author describes in detail the history, construction, and examination potential of the slit lamp. In particular, however, he presents a new approach videography that allows the ophthalmologist to document all (!) eye diseases with the slit lamp and a video camera in a practicable, rapid, and affordable manner. The necessary methods, techniques, and equipment, including converging, diverging, and contact lenses, are clearly explained in the text and four didactic videos. The 20 most important videographic settings are described, and recipes for their use are presented, along with diagnostic tips. The accompanying collection of clinical images represents the world's first ever general atlas of ophthalmology from the perspective of the slit lamp. The author has already demonstrated proof of the value of ophthalmological videography in his own practice. It is his hope that this introductory book, with its many images never previously produced with a slit lamp, will stimulate others to exploit the approach's potential.
  • Slow oscillations in perspective and in detail -- Slow brain oscillations of sleep, resting, state, and vigilance -- Electrophysiological correlates of sleep homeostasis in freely behaving rats -- Involvement of cytokines in slow wave sleep -- Sleep and resting state EEG-profile as heritable endophenotype and during development -- Genetic determination of sleep EEG profiles in healthy humans -- Developmental aspects of sleep slow waves: linking sleep, brain maturation and behavior -- Phasic events during slow oscillations -- Phasic modulation of cortical high-frequency oscillations by pedunculopontine neurons -- Slow oscillations orchestrating fast oscillations and memory consolidation -- Spontaneous neural activity during human non-rapid eye movement sleep -- Thalamocortical and cortico-hippocampal network interactions during slow sleep oscillations -- Neuronal plasticity and thalamocortical sleep and waking oscillations -- Infraslow (<0.1 Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and diseaes states -- Hippocampal-cortical interactions and the dynamics of memory trace reactivation -- Cortica synchronization and travelling of slow oscillations -- Long-range correlation of the membrane potential in neocortical neurons during slow oscillation -- Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves -- Functional beliefs of slow oscillations during sleep -- Sleep and developmental plasticity: not just for kids -- Evoked electrical and cerebral vascular responses during sleep and following sleep deprivation -- Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning -- Infraslow oscillations in resting state network activity during sleep and wakefulness -- Spectral characteristics of resting state networks -- Modulation of the brain's functional network architecture in the transition from wake to sleep -- Spontaneous fMRI activity during resting wakefulness and sleep -- Infraslow oscillations, consciousness and performance -- Hypnotic modulation of resting state mMRI default mode and extrinsic network connectivity -- Multimodal neuroimaging in patients with disorders of consciousness showing functional hemispherectomy -- Roles of multiscale brain activity fluctuations in shaping the variability and dynamics of psychophysical performance.
  • Print Material
    v. 1. Clinical, epidemiological, genetic, and pathological aspects of the spongiform encephalopathies -- v. 2. Pathogenesis, immunology, virology, and molecular biology of the spongiform encephalopathies.
  • Pt. I. Role of Small Animal Imaging -- 1. Noninvasive Imaging for Supporting Basic Research / Pat Zanzonico -- 2. Non-Invasive Imaging in the Pharmaceutical Industry / John C. Waterton -- 3. How to Set Up a Small Animal Imaging Unit / David Stout -- 4. Noninvasive Small Rodent Imaging: Significance for the 3R Principles / Peter Maier -- Pt. II. Study Planning and Animal Preparation -- 5. Institutional Preconditions for Small Animal Imaging / Rene H. Tolba -- 6. Statistical Considerations for Animal Imaging Studies / Hannes-Friedrich Ulbrich -- 7. Animal Anesthesia and Monitoring / Rene H. Tolba -- 8. Drug Administration / Peter Hauff -- Pt. III. Imaging Modalities and Probes -- 9. How to Choose the Right Imaging Modality / Peter Hauff -- 10. X-Ray and X-Ray-CT / Marek Karolczak -- 11. CT Contrast Agents / Hubertus Pietsch -- 12. Small Animal Magnetic Resonance Imaging: Basic Principles, Instrumentation and Practical Issue / Peter Jakob -- 13. MR Contrast Agents / Silvio Aime -- 14. MR Spectroscopy / Markus Becker -- 15. Ultrasound / Catherine Theodoropoulos -- 16. Ultrasound Contrast Agents / Michel Schneider -- 17. PET and SPECT / Sibylle I. Ziegler -- 18. Radiotracer I: Standard Tracer / Uwe Haberkorn -- 19. Radiotracer II: Peptide-Based Radiopharmaceuticals / Clemens Decristoforo -- 20.Optical Imaging / Vasilis Ntziachristos -- 21. Optical Probes / Kai Licha -- 22. Multi-modal Imaging and Image Fusion / Vesna Sossi -- Pt. IV. Ex Vivo Validation Methods -- 23. Ex Vivo and In Vitro Cross Calibration Methods / Thierry Delzescaux -- 24. In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting / David Stout -- pt. V Data Postprocessing -- 25. Qualitative and Quantitative Data Analysis / Volkmar Schulz -- 26. Guidelines for Nuclear Image Analysis / Bernd J. Pichler -- 27.Kinetic Modelling / Jorg van den Hoff -- 28.Data Documentation Systems / Wolfhard Semmler -- Pt. VI. Special Applications -- 29. Imaging in Developmental Biology / Michal Neeman -- 30. Imaging in Gynecology Research / Michael D. Menger -- 31. Imaging in Cardiovascular Research / Sven Hermann -- 32. Imaging in Neurology Research I: Neurooncology / Andreas H. Jacobs -- 33. Imaging in Neurology Research II: PET Imaging of CNS Disorders / Alexander Drzezga -- 34. Imaging in Neurology Research III: Focus on Imaging Neurotransmitter / Wynne K. Schiffer -- 35. Imaging in Oncology Research / Fabian Kiessling -- 36. Imaging in Immunology Research / Owen N. Witte.
  • Reductive activation of dioxygen by copper to generate potent oxidants for multi- electron organic transformations is exploited extensively in biological systems. This thesis focuses on two types of multi-electron oxidants: Cu2O2 complexes and copper complexes with redox-active ligands. The goal of this work is to identify the influence of nitrogen containing ancillary ligands on properties of dioxygen, semiquinone and phenoxyl radical complexes of copper. This work is aimed primarily at synthetic chemists interested in rational design of ligands for creating bio-inspired oxidants and oxidation catalysts. Chapter 1 of this thesis reports the identification of a Density Functional Theory (DFT) protocol for deriving structure-property relationships in Cu2O2 complexes. Chapter 2 of this thesis applies towards modeling electronic spectra, the DFT protocols that were validated in Chapter 1 for modeling thermodynamics. Chapter 3 of this thesis describes the properties and reactivity of Cu2O2 complex generated from a new hybrid permethylated-amine-guanidine ligand based on a 1,3- propanediamine backbone (2L). Chapter 4 of this thesis describes the characterization of an intermediate (C) that is observed in both phenol hydroxylation and catechol oxidation with the SP core supported by N1, N2-di-t-butylethane-1,2-diamine (DBED). Chapter 5 of this thesis describes the influence of sulfanyl substituents on the optical and redox properties of copper-bonded phenoxyls.
  • Also available: Print – 2001
  • Like many fields of science, the future of medicine is frequently predicted by the science fiction writers of today, very much as many of today's medical advances were presaged by science fiction stories of the past. In this book, physician and science fiction author Brad Aiken conveys his own speculations about our medical future through nine highly entertaining and thought-provoking short stories. Touching upon a great variety of themes, including but not limited to telemedicine and remote surgery, vaccination strategies against unknown deathly pathogens, nanomedicine to cure diseases and retard ageing, bionics, cloning and euthanasia, we get a glimpse of what might be awaiting humanity. Yet, in these stories it is always the protagonists, humans after all, who remain at the center stage, not the new technologies. This provides the fictional material with a unique blend of science fiction and social fantasy. It also warns us to be wary of the pitfalls of too much reliance on dehumanizing technology and to make sure it remains our helper, not our master. Last but not least, an extensive scientific essay investigates the interplay between science fiction and both past and current advances in medical sciences and technology, making the link to the fictional material in the book as well as to the relevant scientific literature.
  • Children born small for gestational age : definitions and etiology / Wollmann, H.A. -- Diagnosis and management of in utero growth failure / Odibo, A.O.; Sadovsky, Y. -- Fetal growth restriction and the developmental origins of adult disease hypothesis : experimental studies and biological consequences / Krechowec, S.O.; Thompson, N.M.; Breier, B.H. -- Molecular genetic disorders of fetal growth / Chernausek, S.D. -- Birth weight and later risk of type 2 diabetes / Harder, T. ... [et al.] -- Low birth weight and optimal fetal development : a global perspective / Franko, K.L. ... [et. al.] -- Insulin-like growth factor/growth hormone axis in intrauterine growth and its role in intrauterine growth retardation / Kiess, W. ... [et al.] -- Clinical management of small-for-gestational-age babies / Knüpfer, M. -- Management of short stature in small-for-gestational-age children / Dahlgren, J. -- Puberty and adrenarche in small-for-gestational-age children / Hokken-Koelega, A.C.S. -- Neurological and intellectual consequences of being born small for gestational age / Tuvemo, T.; Lundgren, E.M. -- Low birth weight in developing countries / Qadir, M.; Bhutta, Z.A.
  • pt. B ScienceDirect
    pt. C ScienceDirect
    Also available: Print – pt. A-C, 1995.
    pt. A. Ras family -- pt. B. Rho family -- pt. C. Proteins involved in transport.
  • Small GTPases in disease. Part A-B pt. A-B, 2008.
    pt. B ScienceDirect
    Also available: Print – pt. A-B, 2008.
  • This thesis explores the use of small heat shock proteins as anti-inflammatory therapeutics in the context of neurological diseases, specifically multiple sclerosis (MS) and stroke. The family of small heat shock proteins (sHSPs) has been extensively studied as intracellular molecular chaperones. However, recent studies looking at the role of sHSPs in neurological diseases have demonstrated a near universal upregulation of certain sHSPs in damaged and diseased brains. Initially, it was thought that sHSPs are pathological in these disease states, but transgenic overexpression and exogenous administration of sHSPs in various experimental disease paradigms have shown just the contrary -- that sHSPs are protective, not pathological. In this thesis, I have found that members of the family of sHSPs are protective and therapeutic in mouse models of multiple sclerosis and stroke, experimental autoimmune encephalomyelitis (EAE) and middle cerebral artery occlusion (MCAO), respectively. Alpha B crystallin (cryab), a member of the sHSP family, is elevated in stroke and deficiency of cryab leads to worse disease outcome, illustrating the protective role of alpha B crystallin. Exogenous administration of small heat shock proteins, including alpha B crystallin, decreases disease severity by modulating the immune system. This leads to the conclusion that sHSPs are endogenous anti-inflammatory and neuroprotectant molecules produced after neurological disease, whose beneficial properties can be augmented when administered therapeutically.
  • Minimally invasive joint replacement has become one of the hottest topics in the orthopedic world. In the case of the knee, however, this concept has been widely misunderstood. All too frequently it is taken to mean keyhole surgery in which traditional components are implanted with a shorter surgical time. Such an approach in fact has few benefits and various possible dangers. In this book, international experts discuss truly minimally invasive knee reconstruction techniques that involve tissue-sparing surgery and small implants and permit preservation of both the anterior and the posterior cruciate ligament. These techniques have the key advantage of respecting the physiological joint biomechanics. They also entail minimal removal of bone tissue from the tibia and only a small skin incision that avoids damage to the extensor apparatus. All of the most innovative techniques used in uni- and bicompartmental knee reconstruction are covered in detail, including computer-assisted procedures. Long-term results are reported, and pitfalls, highlighted. The reader will learn how, with careful selection of patients and rigorous surgical technique, compartmental reconstruction offers a valid alternative to total knee replacement.
  • The Expanding World of Small Molecule Microarrays / Mahesh Uttamchandani and Shao Q. Yao -- Construction of Photo-Cross-Linked Microarrays of Small Molecules / Naoki Kanoh -- Small Molecule Microarray : Functional-Group Specific Immobilization of Small Molecules / Hyang Yeon Lee and Seung Bum Park -- Detecting Protein-Small Molecule Interactions Using Fluorous Small Molecule Microarrays / Arturo J. Vegas and Angela N. Koehler -- A Method for Small Molecule Microarray-Based Screening for the Rapid Discovery of Affinity-Based Probes / Haibin Shi, Mahesh Uttamchandani, and Shao Q. Yao -- Nanodroplet Chemical Microarrays and Label-Free Assays / Dhaval Gosalia and Scott L. Diamond -- Nanodroplet Microarrays for High-Throughput Enzyme Screening / Kang L.D. Aw, Shao Q. Yao, and Mahesh Uttamchandani. The Application of the Chemical Array for Biological Study / Isao Miyazaki, Siro Simizu, and Hiroyuki Osada -- Peptide Arrays with a Chip / Alexander Nesterov, Edgar Dörsam, Yun-Chien Cheng, Christopher Schirwitz, Frieder Märkle, Felix Löffler, Kai König, Volker Stadler, Ralf Bischoff, and Frank Breitling -- In situ Chemical Modification of Peptide Microarrays : Characterization by Desorption/Ionization on Silicon Nanowires / Gaëlle Piret, Herv Drobecq, Carine Rouanet, Karim Chemlal, Anne-Sophie Debrie, Jean-Michel Hougardy, Françoise Mascart, Camille Locht, and Oleg Melnyk -- Peptide Microarrays on Coated Silicon Slides for Highly Sensitive Antibody Detection / Marina Cretich, Francesco Damin, Renato Longhi, Cecilia Gotti, Clelia Galati, Lucio Renna, and Marcella Chiari. Antibody Signatures Defined by High-Content Peptide Microarray Analysis / Antonia Masch, Johannes Zerweck, Ulf Reimer, Holger Wenschuh, and Mike Schutkowski -- High Density Peptide Microarrays for Proteome-Wide Fingerprinting of Kinase Activities in Cell Lysates / Alexandra Thiele, Matthias Weiwad, Johannes Zerweck, Gunter Fischer, and Mike Schutkowski -- A Peptide Microarray for Detecting Protein Kinase Activity in Cell Lysates / Xiaoming Han and Yoshiki Katayama -- Chemical Microarrays Constructed by Selective Attachment of Hydrazide-Conjugated Substances to Epoxide Surfaces and Their Applications / Sungjin Park, Myung-Ryul Lee, and Injae Shin -- A Microarray-Based Method to Perform Nucleic Acid Selections / Olga Aminova and Matthew D. Disney.
  • Protein kinase inhibitors -- Imatinib mesylate -- Erlotinib -- Axitinib -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358): a novel combined pan-aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor -- BI_2536: targeting the mitotic kinase polo-like kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L): Telomerase-based cancer therapy -- GDC-0449: targeting the hedgehog signaling pathway.
  • Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
  • Introduction -- Inheritance of small supernumerary marker chromosomes -- Formation of small supernumerary marker chromosomes -- Small supernumerary marker chromosomes in genetic diagnostics and counseling -- Small supernumerary marker chromosomes known to be correlated with specific syndromes -- Centric small supernumerary marker chromosomes -- Neocentric small supernumerary marker chromosomes by chromosome -- Multiple small supernumerary marker chromosomes -- Small supernumerary marker chromosomes additionally to other chromosomal rearrangements -- Complex small supernumerary marker chromosomes -- Small supernumerary marker chromosomes and tumors -- Appendix: Patient organizations in connection with small supernumerary marker chromosomes -- Glossary.
  • Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions / M.J. Adler, A.G. Jamieson and Andrew D. Hamilton -- Small-molecule inhibitors of IL-2/IL-2R : Lessons learned and applied / C.G. Wilson and M.R. Arkin -- Small molecule inhibitors of the human papillomavirus E1-E2 interaction / P.W. White, Anne-Marie Faucher and Nathalie Goudreau -- Design of small-molecule Smac mimetics as IAP antagonists / Shaomeng Wang -- Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule / Benjamin D. Zeitlin and Jacques E. Nör -- Small-molecule modulators of c-Myc/Max and Max/Max interactions / Thorsten Berg -- Small-molecule inhibitors of the p53-MDM2 interaction / Binh T. Vu and Lyubomir Vassilev.
  • "Scientifically known as Variola major, the deadliest form of smallpox has plagued mankind since 'time immemorial.' This text chronicles the worldwide effects of the killer disease, with particular emphasis on the 19th and 20th centuries, including the devastations of the "speckled disease" during great armed conflicts"--Provided by publisher.
  • "Planning, conducting, and publishing the results of your clinical research can be a long and arduous journey. The SMART Approach to Spine Clinical Research presents and explains the many interrelated components essential to spine clinical research in an easily accessible way, guiding you step-by-step through the principles and methods of planning and evaluating clinical research."--Cover.
  • The team physician and general care of the athlete / Jennifer Hart -- Medical issues in the athlete / Jennifer Hart -- Shoulder / S. Raymond Golish ... [et al.] -- Elbow / Luke S. Oh -- Wrist & hand / Jack Ingari -- Knee / Mark D. Miller -- Hip, pelvis and thigh / Brian D. Busconi & Robert M. Masella -- Ankle and foot / Anish R. Kadakia & David Joos -- Head and spine / Sanjitpal S. Gill & Katey A. Dorweiler -- Sports medicine research and statistics / Joseph M. Hart.
  • Smith & Tanagho's General urology 2013 (18th ed.)
    Also available: Print – <2013>
  • A practical guide for anaesthetists and other health care professionals involved in the perioperative period. This sixth edition has been thoroughly updated and reorganised to reflect current anaesthetic practice and the basic sciences that directly underpin it. The inclusion of several new chapters continues to ensure complete coverage of key and evolving areas and new, experienced authors also add a fresh perspective to this edition.
  • 2011 ClinicalKey
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  • The Medical Interview -- Data-Gathering and Relationship-Building Skills -- The Beginning of the Interview: Patient-Centered Interviewing -- Symptom-Defining Skills -- The Middle of the Interview: Clinician-Centered Interviewing -- Step 11: The End of the Interview -- Adapting the Interview to Different Situations and Other Practical Issues -- The Clinician-Patient Relationship -- Summarizing and Presenting the Patient's Story.
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  • This medical reference book provides you with complete and authoritative, yet accessible guidance to help accurately diagnose these human disorders, establish prognoses, and provide appropriate management and genetic counseling. Recognize the visual signs of each environmental and genetic abnormality by consulting more than 1,500 full-color photographs and illustrations, many from the personal collections of Drs. Smith and Jones. Find all the answers you need about normal and abnormal morphogenesis, minor anomalies and their relevance, clinical approaches to specific diagnoses, and normal standards of measurement for the entire spectrum of human malformation syndromes. Efficiently identify genetic disorders in your patients with the inclusion of nearly 20 recently recognized entities/syndromes, as well as new chapters on Microdeletions and Microduplication Syndromes.
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  • Also available: Print – 2007
  • Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases. Second, it is unique with respect to scope of the discussion of the unusual characteristics of the immune response which occurs in these patients. Third, it includes knowledge being gained from translational research conducted through clinical trials at several Medical Schools in the United States. Not only is this research providing information about novel drugs and therapies, but it is also advancing our understanding of the genetics of these diseases. This work will illuminate the molecular basis for these diseases, and hopefully will permit us to individualize the therapies for these diseases.
  • From nicotine dependence to genetic determinants of smoking -- State of the art of smoking habits in the world -- Smoking-related diseases epidemiology -- Smoking-related cancer epidemiology -- Classical determinants of smoking initiation -- Smoking prevention in the communities -- Smoking prevention through mass media campaigns -- How to tackle smoking at the population level -- Smoking among health professionals -- Basic principles of smoking cessation techniques -- Smoking cessation among different settings -- Media and smoking cessation -- Ethical aspects of tobacco smoking -- Economic issues related to tobacco smoking -- Appendix.
  • Also available: Print – 2005
  • Viscosity -- Law of Poiseuille -- Bernoulli's equation -- Turbulence -- Arterial stenosis -- Resistance -- Inertance -- Oscillatory flow theory -- Law of Laplace -- Elasticity -- Compliance -- Cardiac muscle mechanics -- The pressure-volume relation -- The pump function graph -- Cardiac work, energy and power -- Cardiac oxygen consumption and hemodynamics -- Cardiac power and ventriculo-arterial coupling -- The coronary circulation -- Assessing ventricular function -- Wave travel and velocity -- Wave travel and reflection -- Waveform analysis -- Arterial input impedance -- The arterial windkessel -- Distributed models and tube models -- Transfer of pressure -- Mechanotransduction and vascular remodeling -- Blood flow and arterial disease -- Determinants of pressure and flow -- Comparative physiology -- Times and sines: Fourier analysis -- Basic hemodynamic elements -- Vessel segment -- Wave speed and characteristic impedance -- Basic aspects -- Books for reference -- Symbols -- Units and conversion factors.
  • Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. An additional booklet containing 100 tables on muscles and nerves supports systematic study. Volume 1 "General Anatomy and Musculoskeletal System" includes the following topics: General Anatomy Trunk Upper Extremity Lower Extremity.
  • Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. Volume 3 "Head, Neck and Neuroanatomy" includes the following topics: HeadEyeEarNeckBrain and Spinal Cord.
  • Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. An additional booklet containing 100 tables on muscles and nerves supports systematic study Volume 2 "Internal Organs" includes the following topics: Viscera of the Thorax, Viscera of the Abdomen Pelvis, and Retroperitoneal Space.
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    v. 1. The household survey in Indianapolis -- v. 2. The intensive study : purpose, scope, methods, and partial results.
  • This volume brings together research into diverse aspects of social anxiety and its clinical form, social phobia, in adolescents. Development of the condition, clinical manifestations, and evidence-based prevention and treatment strategies are all addressed, with emphasis on ways in which adolescent development and the broader family and peer context are reflected in the manifestation and treatment of symptoms. The first part of the book reviews epidemiological, neurobiological, and sociopsychological research on vulnerability factors that aim to clarify why both social anxiety and phobia intensify in adolescence. The second part focuses on the phenomenology of social anxiety and phobia in different developmental contexts and provides the reader with a review of developmentally-appropriate evidence-based assessment methods. For example, this section includes chapters on social anxiety in the school environment and in romantic relationships, social phobia in the clinical setting. The third section reviews the psychosocial prevention and treatment options for adolescent social anxiety as well as the psychopharmacological treatment of social phobia. Social Anxiety and Phobia in Adolescents will be informative and interesting for all child and adolescent psychiatrists, clinical psychologists, and psychotherapists as well as for school psychologists and counsellors.
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    Based on a lifetime of pioneering research, preeminent naturalist Edward O. Wilson gives us a new history of human evolution, presented in an elegant and provocative narrative that promises to have reverberations in fields as diverse as anthropology and social psychology, neuroscience and 21st-century intellectual and religious history. Wilson begins by addressing three "fundamental questions" of religion and philosophy that have fascinated thinkers for centuries: Where did we come from? What are we? Where are we going? Writing that "the origin of modern humanity was a stroke of luck, good for our species for a while, bad for most of the rest of life forever," Wilson traces the rise of Homo sapiens from its infancy, drawing on his remarkable knowledge of biology and social behavior to present us with the clearest explanation ever produced as to the origin of the human condition. Wilson also reveals how "group selection" can be the only model for explaining man's origins and domination, and warns that it has now accelerated--through unregulated and untrammeled growth--to such a point that the planet as we know it is being threatened.--From publisher description. From the most celebrated heir to Darwin comes a groundbreaking book on evolution, the summa work of Edward O. Wilson's legendary career.
  • Also available: Print – 2011
    "The thirteen case studies presented in this publication describe experiences with implementing public health programs that intend to address social determinants and to have a great impact on health equity. They also document the real-life challenges in implementing such programs, including the challenges in scaling up, managing policy changes, managing intersectoral processes, adjusting design and ensuring sustainability"--Publisher's description.
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    "Serious disparities continue to exist especially with regard to African-American men who continue to suffer disproportionately from poor health when compared to other racial, ethnic, and gender groups in the United States. This book covers the most important issues relating to social determinants of health and also offers viable strategies for reducing health disparities." --Excerpts from publisher description.
  • Chapter 1. Introduction / Jonathan Wells, Simon Strickland, and Kevin Laland -- Chapter 2. An Introduction to evolutionary models of human social behavior / Kevin Laland and Gillian Brown -- 3. How niche construction contributes to human gene-culture coevolution / John Odling-Smee -- Chapter 4. State and value : a perspective from behavioral ecology / John M. McNamara and Alasdair I. Houston -- Chapter 5. An Agnostic view of memes / Robert Aunger -- Chapter 6. Biological ends and human social information transmission / Jonathan Wells and Simon Strickland -- Chapter 7. The Significance of socially transmitted information for nutrition and health in the great ape Clade / Andrew Whiten -- Chapter 8. Language : costs and benefits of a specialized system for social information transmission / Daniel Nettle -- Chapter 9. The Evolution of social information transmission in Homo / Steven Mithen -- Chapter 10. From cultural history to cultural evolution : an archaeological perspective on social information transmission / Stephen Shennan -- Chapter 11. The Uptake of modern contraception in a Gambian community : the diffusion of an innovation over 25 years / Ruth Mace, Nadine Allal, Rebecca Sear, and Andrew Prentice -- Chapter 12. Sex without birth or death : a comparison of two international humanitarian movements / John Cleland and Susan Watkins -- Chapter 13. Smoking and the new health education in Britain, 1950s-1970s / Virginia Berridge and Kelly Loughlin -- Chapter 14. The Demographic and health impact of the one child family policy / Therese Hesketh -- Chapter 14. Social trends and psychopathology / Roland Littlewood -- Chapter 16. Epilogue : memory, tradition, and teleology / Simon Strickland.
  • This report sets out to illuminate the different ways people seek health information as well as how people use online social tools to share knowledge with loved ones, fellow patients, and caregivers.
  • Social media has been clearly changing the way medicine is practiced and healthcare is delivered. Medical professionals must be able to meet the special needs of technology-aware patients and use digital technologies in their work and communications properly. Each physician should find the tools that will assist them in their workflow, and patients need to be educated how to use the internet. It is the responsibility of medical professionals to contribute to this process. The constantly evolving digital world must be used in the practice of medicine to improve the care of patients. However, the only way to do so effectively is via evidence-based, meaningful and strategic use. Social Media in Clinical Practice provides practical guidance in this mission and is thus essential reading for all medical personal looking into approaching this for the first time.
  • Measures national progress in delivering social and environmental value to citizens. Includes statistical rankings by country in various areas, including health and wellbeing. It is designed as a complement to GDP and other economic indicators to provide a more holistic understanding of countries' overall performance.
  • People with severe physical disabilities who have non-technical backgrounds are unlikely candidates to be able to operate vocational assistive robots. Such robotic devices have been costly, complex, programmable only by experts, and prohibitive to user changes. This dissertation describes the design approach created in the development of a small desktop robot system called the Professional Vocational Assistant Robot (ProVAR). ProVAR deals explicitly with the social aspects of human-robot interaction to help individuals with tetraplegia to use the robot. This design approach was heavily influenced by the theory of Social Responses to Communication Technologies (SRCT) and by psychology research that shows the power of a team in complex command, design and learning scenarios. The SRCT concept holds that people's reactions and interactions with computers and other new media entities follow the same social rules used in human-human interactions. If those reactions can be enhanced, the success of assistive robotic systems dependent on them can also be increased. The leveraging of social responses can increase tolerance for the robotic systems' difficulties, and thus increase the chance of adoption and sustained use of the assistive devices by lay users not experienced in computers, robots, or mechanical control devices. A new theory, growing out of SRCT, was proposed. "Social Responses to Somatic Technology" (SRST) guided the development of ProVAR. It is based on a robot users perception that a somatic, e.g., robotic, technology device is, in fact, a social entity. As does a human social entity, each technological social entity consists of two components: the "body" and the "mind." The ProVAR System was designed with two complete social entities, or personalities; both induce social responses. Each of ProVAR's two personalities is expected to maintain a personal relationship with the users, in this case, with an individual with severe physical disabilities and with the occupational therapist responsible for his/her rehabilitation. ProVAR's graphical user interface, named "Jiminey, " is primarily considered by the user to be a mind: a smart consultant/coach. ProVAR's robotic arm, "Pinocchio, " is primarily perceived by the user to be a body: the down-to-earth do'er itself. Even though each of these social entities does have both a body and a mind, each personality's different dominant characteristic allows the user to perceive that he/she is functioning as a teammate with two other distinct entities. These three partners work together to help manage and take advantage of the special capabilities of the ProVAR System to complete desired tasks. During Experiment 1, ProVAR showed 100% of novice users able independently to execute both preprogrammed tasks and also the more complicated manipulation of existing tasks and creation of new ones. ProVAR's SRST-inspired design is effective, with seven of eight metrics positively ranked by users. One additional finding showed that training first on the user interface alone without the presence of the robotic arm was not time effective. A further examination of the application of the SRST concept of "Social Entity = Body + Mind" was done in Experiment 2, studying the effect of the body and the mind of the robotic arm being perceived not to be co-located but in separate locations. Results showed that usability was ranked higher by the study participants if the arm (the body) was perceived as autonomous, i.e., controlling itself (by its mind) with an internal inboard computer, rather than the arm being remote-controlled, i.e., teleoperated (by its mind), in a computer located in another room.
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    What is social software? -- Blogs -- Blogs in libraries : practical applications -- RSS -- Wikis -- Online communities -- Social networking -- Social bookmarking and collaborative filtering -- Tools for synchronous online reference -- The mobile revolution -- Podcasting -- Screencasting and vodcasting -- Gaming -- What will work @ your library -- Keeping up : a primer -- Future trends in social software.
  • Chapter 1: Introduction to socio-ecological dimensions of infectious diseases and health in Southeast Asia. -- Part 1: Infectious Diseases and Societies -- Chapter 2: Climate, environment and epidemic febrile diseases: A view from Chinese medicine -- Chapter 3: Long life of people living with HIV/AIDS and the practice of medical power -- Chapter 4: Socio-environmental global changes and infectious diseases: Interdisciplinary approach applied to tourism studies -- Part 2: Socio-Ecosystems and Health -- Chapter 5: Heavy metals contamination in the ecosystem of Mae Tang reservoir in Northern Thailand -- Chapter 6: Water and health: What is the risk and visible burden of the exposure to environmental contaminations? Insights from a questionnaire-based survey in Northern Thailand -- Chapter 7: Melioidosis in Laos -- Part 3: Global Changes, Land Use Changes and Vector-Borne Diseases -- Chapter 8: Adaptation of mosquito vectors to salinity and its impact on mosquito-borne disease transmission in the South and Southeast Asian tropics -- Chapter 9: The malaria landscape: Mosquitoes, transmission, landscape, insecticide resistance and integrated control in Thailand -- Chapter 10: Rubber plantations as a mosquito box amplification in South and South-East Asia -- Part 4: Monitoring and Data Acquisition -- Chapter 11: Rescuing public health data -- Chapter 12: The new science of metagenomics and the challenges of its use in both developed and developing countries -- Chapter 13: Barcoding, biobanking, e banking: From ecological to ethical and legal aspects. Insights from the PathodivSEA project -- Part 5: Managing Health Risks -- Chapter 14: Methods for prioritization of diseases: Case study of zoonoses in South-East Asia -- Chapter 15: Managing global risks: Vietnamese poultry farmers and avian flu -- Chapter 16: The OIE Strategy to address threats at the interface between humans, animals and ecosystems -- Part 6: Developing Strategies -- Chapter 17: Business for biodiversity and ecosystem services -- Chapter 18: Bridging the gap between conservation and health -- Chapter 19: Implementation of the One health strategy. Lessons learnt from community based natural resource programs for communities' empowerment and equity within an Eco health approach.
  • This book provides a comprehensive examination of the complex issues surrounding the regulation of the medical profession. It offers up-to-date information on the current legislative framework and institutional arrangements surrounding the regulation in the United Kingdom. Well organized and written in an accessible way, it offers an insight into key sociological theories surrounding medical regulation. It gives a historically situated analysis of the contemporary relationship between medicine, the state and the public, and an overview of relevant social scientific research. Case studies highlight the practical or applied circumstances in which issues can occur. Readers will gain insight into possible future directions for medical governance.
  • "The Sociology of Medical Screening: Critical Perspectives, New Directions presents a series of readings that provide an up-to-date overview of the diverse sociological issues relating to population-based medical screening. Features new research data in most of the contributions. Includes contributions from eminent sociologists such as David Armstrong, Stefan Timmermans, and Alison Pilnick. Represents one of the only collections to specifically address the sociology of medical screening"--Provided by publisher.
  • Also available: Print – 2013
  • Also available: Print – 2005
  • This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on soft tissue augmentation techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offer step-by-step advice on proper techniques, pitfalls, and tricks of the trade-so you can refine and hone your skills ... and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of traditional and new fillers-edited by pioneers in the field, Drs. Alastair and Jean Carruthers. Implement the newest procedures into your practice immediately and confidently-with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Get the best results from permanent fillers that stimulate the body's own collagen, new hypoallergenic fillers, injectable Zyderm and Zyplast collagen, and Gore-Tex chin, lip and cheek implants -all with one concise, accessible volume. Visualize techniques clearly with a wealth of color illustrations and photographs that depict cases as they appear in practice. Browse the fully searchable text online at, along with expanded video content and downloadable images.
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  • Also available: Print – 2011
  • Nature, distribution, and origin of soil materials in the forensic comparison of soils / Robert W. Fitzpatrick -- Cadaver decomposition and soil: processes / David O. Carter and Mark Tibbett -- The role of soil organisms in terrestrial decomposition / David W. Hopkins -- Soil fungi associated with graves and latrines: towards a forensic mycology / Naohiko Sagara, Takashi Yamanaka, and Mark Tibbett -- The role of invertebrates in terrestrial decomposition: forensic applications / Ian R. Dadour and Michelle L. Harvey -- The decomposition of hair in the buried body environment / Andrew S. Wilson -- The decomposition of materials associated with buried cadavers / Robert C. Janaway -- Decomposition chemistry in a burial environment / Shari L. Forbes -- Potential determinants of postmortem and postburial interval of buried remains / Shari l. Forbes -- Principles and methodologies of measuring microbial activity and biomass in soil / Phil Brookes -- Methods of characterizing and fingerprinting soils for forensic application / Lorna A. Dawson ... [et al.].
  • Also available: Print – 1997
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    List of illustrations -- Foreword -- Preface -- Acknowledgments -- Introduction: Fuller's arrival in Germany, 1905 -- The beginning: John Lewis Fuller, Norfolk, Virginia, 1830 -- A new life in Africa: Monrovia, 1852 -- In pursuit of a dream: North Carolina, 1889 -- Learning and teaching: Boston, 1897 -- The science of German: Munich, 1904 -- The doctor and the sculptor: Westboro, 1906 -- Pioneer in American psychiatry: Framingham, 1909 -- Contributions to science and medicine: Westborough, 1911 -- The later years: Framingham, 1933 -- Recognition of accomplishments: Boston, 1974 -- Epilogue: Washington DC, 2001 -- Appendix: publications of Solomon Carter Fuller -- Notes -- About the author -- Index.
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    1. The Genetics Revolution in the Life Sciences -- pt. I. TRANSMISSION GENETICS -- 2. Single-Gene Inheritance -- 3. Independent Assortment of Genes -- 4. Mapping Eukaryote Chromosomes by Recombination -- 5. The Genetics of Bacteria and Their Viruses -- 6. Gene Interaction -- pt. II. FROM DNA TO PHENOTYPE -- 7. DNA: Structure and Replication -- 8. RNA: Transcription and Processing -- 9. Proteins and Their Synthesis -- 10. Gene Isolation and Manipulation -- 11. Regulation of Gene Expression in Bacteria and Their Viruses -- 12. Regulation of Gene Expression in Eukaryotes -- 13. The Genetic Control of Development -- 14. Genomes and Genomics -- pt. III. MUTATION, VARIATION, AND EVOLUTION -- 15. The Dynamic Genome: Transposable Elements -- 16. Mutation, Repair, and Recombination -- 17. Large-Scale Chromosomal Changes -- 18. Population Genetics -- 19. The Inheritance of Complex Traits -- 20. Evolution of Genes and Traits.
  • This book details a model of consciousness supported by scientific experimental data from the human brain. It presents how the Corollary Discharge of Attention Movement (CODAM) neural network model allows for a scientific understanding of consciousness as well as provides a solution to the Mind-Body problem. The book provides readers with a general approach to consciousness that is powerful enough to lead to the inner self and its ramifications for the vast range of human experiences. It also offers an approach to the evolution of human consciousness and features chapters on mental disease (especially schizophrenia) and on meditative states (including drug-induced states of mind). Solving the Mind-Body Problem bridges the gap that exists between philosophers of mind and the neuroscience community, allowing the enormous weight of theorizing on the nature of mind to be brought to earth and put under the probing gaze of the scientific facts of life and mind.
  • Also available: Print – 2006
    Nuclear remodeling and nuclear reprogramming for making transgenic pigs by nuclear transfer / Randall S. Prather -- Somatic cell nuclei in cloning : strangers traveling in a foreign land / Keith E. Latham, Shaorong Gao, and Zhiming Han -- Cloning cattle : the methods in the madness / Bjørn Oback and David N. Wells -- Centrosome inheritance after fertilization and nuclear transfer in mammals / Qing-Yuan Sun and Heide Schatten -- Developmental, behavioral, and physiological phenotype of cloned mice / Kellie L.K. Tamashiro ... [et al.] -- Nucleolar remodeling in nuclear transfer embryos / Jozef Laurincik and Poul Maddox-Hyttel -- Somatic cell nuclear transfer (SCNT) in mammals : the cytoplast and its reprogramming activities / Josef Fulka, Jr. and Helena Fulka -- Mitochondrial DNA inheritance after SCNT / Stefan Hiendleder -- Activation of fertilized and nuclear transfer eggs / Christopher Malcuit and Rafael A. Fissore.
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    1. Introduction: Narrativitzing the body -- 2. The Patient's body in Indian medical literature -- 3. Fever -- 4. Miscarriage -- 5. The King's disease -- 6. The Joy of life [Jīvānandanam] of Ānandarāyamakhin -- 7. Conclusion: Medical narratives and the narrativized patient.
  • Also available: Print – 2010
  • Also available: Print – 2010
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  • Also available: Print – 2002
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    Formation and differentiation of avian somite derivatives / Bodo Christ and Martin Scaal -- Avian somitogenesis : translating time and space into pattern / Beate Brand-Saberi, Stefan Rudloff, and Anton J. Gamel -- Genetic analysis of somite formation in laboratory fish models / Christoph Winkler and Harun Elmasri -- Old wares and new : five decades of investigation of somitogenesis in Xenopus laevis / Duncan B. Sparrow -- Role of delta "like" in mammalian somitogenesis and vertebral column formation / Gavin Chapman and Sally L. Dunwoodie -- Mesp-family genes are required for segmental patterning and segmental border formation / Yumiko Saga and Yu Takahashi -- BHLH proteins and their role in somitogenesis / Miguel Maroto ... [et al.] -- Mouse mutations disrupting somitogenesis and vertebral patterning / Kenro Kusumi, William Sewell, and Megan L. O'Brien -- Defective somitogenesis and abnormal vertebral segmentation in man / Peter D. Turnpenny.
  • This thesis encompasses three projects at the intersection of genetics, behavior, and neurobiology in the fruitfly, Drosophila melanogaster. The major work presented is an investigation of the afferent auditory system in D. melanogaster. The afferent auditory system of D. melanogaster arises from the Johnston's Organ in the second antennal segment, from which mechanosensory neurons project to a protocerebral region known as the Antennomechanosensory and Motor Complex (AMMC). The antennal mechanosensory system in Drosophila is used in multiple contexts, including vestibular mechanosensation, wind sensitivity, and courtship hearing. During courtship, male flies present a stereotypic pulse song as well as a hum-like sine-song to female flies; these stimuli are species-specific and critical to female receptivity. Using a large enhancer-Gal4 collection, I identify 12 candidate cell types within the AMMC, divided into 7 types of projection neurons as well as 5 types of local AMMC interneurons. I tested each of these cell types for its effect on courtship hearing by testing the effect of neuronal silencing on a) female receptivity, and b) a male locomotor response (Song-Induced Locomotion). These tests reveal that the activity of one class of projection neuron (aPN1), and one class of local interneuron (aLN(al)) are critical to courtship hearing in both male and female flies. Other cell types appear to be dispensable for courtship hearing, and may play a role in non-courtship related mechanosensation. To help confirm that these phenotypes are not specific to neuronal silencing, I also hyperactivated each cell type using the temperature-sensitive dTrpA1 reagent; these results confirm that aPN1 and aLN(al) alone are necessary for courtship hearing. Overall this work identifies a set of parallel pathways from the AMMC leading to the ventrolateral protocerebrum (VLPR), but reveal that only one of these pathways is necessary for courtship hearing. The structure of this circuit is analogous to the multi-lineage projection identified in D. melanogaster olfaction, in which a parallel pathways share a common projection but carry independent information. In addition to this work, I also discuss an investigation of the role of abnormal-chemosensory jump 6 (acj6) on escape behaviors, as well as an investigation of the expression of doublesex (dsx) in the nervous system.
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    Introduction -- Ultrasound -- Transducers -- Instruments -- Doppler principles -- Artifacts -- Performance and safety -- Review.
  • Sorting and Recycling Endosomes provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. In recent years, the importance of endosomes as a sorting and recycling compartment has become increasingly appreciated. As such, scientists from various fields of cell biology, membrane traffic, and beyond, see the needs to communicate and learn about the methods used to investigate the dynamics and functions of endosomes. This book brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling. This volume covers the approaches necessary to study the key components that mediate the generation and transport of membrane-bounded carriers from the endosomes, and how membrane trafficking machinery is coordinated with cytoskeletons during these processes. In addition to studies carried out in mammalian cells, other model systems such as worm and yeast are also included.
  • Introduction to sound source localization / Richard R. Fay and Arthur N. Popper -- Directional hearing in insects / Daniel Robert -- Sound source localization by fishes / Richard R. Fay -- Directional hearing in nonmammalian tetrapods / Jakob Christensen-Dalsgaard -- Comparative mammalian sound localization / Charles H. Brown and Bradford J. May -- Development of the auditory centers responsible for sound localization / M. Fabiana Kubke and Catherine E. Carr -- Interaural correlation as the basis of a working model of binaural processing: an introduction / Constantine Trahiotis, Leslie R. Bernstein, Richard M. Stern, and Thomas N. Buell -- Models of sound localization / H. Steven Colburn and Abhijit Kulkarni.
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    Paleopathology and primitive medicine -- The Middle East in antiquity -- China and India in antiquity -- Greece -- Rome and Byzantium -- Europe, 500-1500 -- Medicine in the Muslim world and the Americas, 700-1500 -- The Renaissance and the scientific revolution: technical and theoretical change -- Europe, 1500-1800: health, disease, trauma, and society -- The nineteenth century: the development and spread of Western medicine -- The nineteenth century: change and upheaval -- The twentieth century: advances and challenges -- The twentieth century: new enemies, old nemeses -- A brave new century: dilemmas in twenty-first-century medicine.
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    Women living with HIV -- The Cape Coloured community -- A support group for HIV-positive women in Cape Town -- Marginalizing the marginalized through multiple stigmas -- Disclosure for better or worse -- Staking a claim as normal through work and relationships with men -- Care work -- Care work and violent men -- Women's bodies -- Lessons for the world.
  • Also available: Print – 1971
  • Also available: Print – 1973
  • As America's most populous state goes, so goes the nation. And within that state, the 38 counties comprising South Texas--a highly populated, largelyHispanicarea characterized by high uninsured rates and low numbers of health care providers--are emblematic of nationwide crises in public health. The South Texas Health Status Review: A Health Disparities Roadmapbrings health care disparities to light in instructive detail. Over thirty key health conditions and risk factors, such as breast cancer, diabetes, obesity, tuberculosis, smoking and alcohol use, lead exposure, birth defects, and homicide rates, are analyzed by age, sex, race/ethnicity, and location (urban or rural), and the results compared with the rest of Texas and the nation as a whole. A section on conclusions and recommendations outlines factors contributing to these conditions and offers suggestions for improvement. These important data should stimulate further population studies and provide impetus for targeted public health interventions and community outreach programs to reduce health inequities and advance care access in the state and the U.S. at large. Major health issues covered in the report include: Communicable diseases Cancer incidence and mortality Maternal and child health Chronic diseases Behavioral risk factors in adults Environmental health issues Suicide, homicide, and vehicular mortality The South Texas Health Status Reviewcontains valuable lessons for researchers in health promotion and health disparities, as well as community health professionals. Policymakers involved in reducing health disparities will find it especially useful.
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  • Chapter 1. Historical Aspects -- Introduction -- Importance of Soy Protein Products -- Chapter 2. Definitions and Methods of Preparation -- Introduction -- Soy Flours and Grits -- Partially Defatted Extruded-Expelled Soy Flours -- Textured Soy Flour -- Soy Protein Concentrates -- Textured Soy Protein Concentrates -- Soy Protein Isolates -- Structured Isolates -- Speciality Soy Foods and Ingredients -- Chapter 3. Protein Quality and Human Nutrition -- Introduction -- Factors Affecting Protein Quality -- Amino Acid Composition -- Amino Acid Requirements -- Digestibility -- Protein Digestibility-Corrected Amino Acid Score (PDCAAS) -- Evaluation of Soy Protein Products in Human Nutrition -- Evaluation of Soy Protein Products in Specific Foods -- Infant Formulas -- Meats and Fish -- Special Nutritional Products -- Mixtures of Soy Bean and Cereal Grains and Alternate -- Protein Sources -- Mineral Content and Mineral Bioavailability -- Sodium -- Bioavailability of Minerals (excluding Iron) -- Bioavailability of Iron -- Calories -- Nutritional Significance of Protease Inhibitors -- Chapter 4. Health and Soy Protein -- Introduction -- Coronary Heart Disease -- Calorie Control -- Dietary Fiber -- Additional Nutritional Issues -- Carbohydrates and Flactulence -- Immunochemical Properties -- Safety, Microbiology, and Sanitation Toxic Factors -- Microbiology and Sanitation -- Chapter 5. Functionality of Soy Proteins -- Introduction -- Functionality of Soy Protein Ingredients -- Soy Flours and Grits -- Soy Protein Concentrates -- Soy Protein Isolates -- Soy Protein Hydrolyzates -- Texture and Structured Soy Protein Products -- Textured Soy Flours and Concentrates -- Structured Isolates -- Chapter 6. Uses in Food Systems -- Introduction -- Bakery Products -- Milk Replacers -- Bread and Rolls -- Specialty Bread -- Cakes and Cake Mixes -- Cookies, Crackers, Biscuits, Pancakes, and Sweet Pastry -- Doughnuts -- Pasta Products -- Breakfast Cereals -- Dairy-Type Products -- Beverages and Toppings -- Infant Formulas and Special Nutritional Products -- Milk Replacers For Young Animals -- Meat Products -- Emulsified Meat Products -- Coarsely Chopped (Ground) Meats -- School Lunch and Military Uses -- Canned Meats -- Whole Muscle Meats -- Poultry Products -- Seafood Products -- Analog Products -- Miscellaneous Foods -- Chapter 7. Regulations Regarding Usage -- Introduction -- Meat and Poultry Products -- Bakery Products and Pasta -- Dairy Products and Margarine/Edible Spreads -- Formulated Foods -- Chapter 8. Future Considerations -- Introduction -- Economics -- References.
  • "The study of mathematical cognition and the ways in which the ideas of space, time and number are encoded in brain circuitry has become a fundamental issue for neuroscience. How such encoding differs across cultures and educational level is of further interest in education and neuropsychology. This rapidly expanding field of research is overdue for an interdisciplinary volume such as this, which deals with the neurological and psychological foundations of human numeric capacity. A uniquely integrative work, this volume provides a much needed compilation of primary source material to researchers from basic neuroscience, psychology, developmental science, neuroimaging, neuropsychology and theoretical biology."--Publisher's description.
  • Cerebral palsy detection : from John Little to the present / Giovanni Cioni, Paola B. Paolicelli -- Guide to the interpretation of cerebral palsy / Adriano Ferrari, Silvia Alboresi -- Functional diagnosis in infants and in very young children : early predictive signs / Giovanni Cioni, Andrea Guzzetta, Vittorio Belmonti -- Motor defects / Adriano Ferrari -- Perceptive defects / Adriano Ferrari -- Praxic organization disorders / Simonetta Muzzini, Federico Posteraro, Roberta Leonetti -- Visual and oculomotor disorders / Andrea Guzzetta ... [et al.] -- Neuropsychological evaluation / Daniels Brizzolara, Paola Brovedani, Giovanni Ferretti -- Emotional, behavioral and social disorders in children and adolescents with cerebral palsy / Gabriele Masi, Paolo Brovedani -- Observing interactions / Sandra Maestro -- Critical aspects of classifications / Adriano Ferrari -- Kinematic classification / Adriano Ferrari -- Tetraplegic forms / Adriano Ferrari ... [et al.] -- Dysperceptive forms / Silvia Alboresi ... [et al.] -- Forms of diplegia / Adriano Ferrari ... [et al.] -- Forms of hemiplegia / Giovanni Cioni ... [et al.].
  • Statistical analysis of spatial structure in microbial communities / Rima B. Franklin, Aaron L. Mills -- Bacterial interactions at the microscale - linking habitat to function in soil / Naoise Nunan ... [et. al] -- Spatial distribution of bacteria at the microscale in soil / Arnaud Dechesne, Céline Pallud, Geneviève L. Grundmann -- Analysis of spatial patterns of rhizoplane colonization / Guy R. Knudsen, Louise-Marie Dandurand -- Microbial distributions and their potential controlling factors in terrestrial subsurface environments / R. Michael Lehman -- Spatial organisation of soil fungi / Karl Ritz -- Spatial heterogeneity of planktonic microorganisms in aquatic systems / Bernadette Pinel-Alloul, Anas Ghadouani -- The interrelationship between the spatial distribution of microorganisms and vegetation in forest soils / Sherry J. Morris, William J. Dress.
  • GIS concepts and operations -- GIS and geographic data -- Spatial analysis software and methods -- Point pattern methods of disease analysis -- Areal methods of disease analysis -- Interpolation and associative analysis -- Initiating a GIS project in spatial epidemiology -- Current GIS research in health care and disease analyses.
  • Not only do biological systems consist of an extraordinarily complex cast of molecules, these molecules are well-organized in space: first into compartments, which form cells, which act in concert as tissues, which finally make up organisms. This thesis focuses on specific examples of how complicated biological systems create and maintain their intricate spatial organization. The tools of mathematical modeling have greatly assisted scientists' understanding of spatial patterning. In particular, models can help to distill a complicated phenomenon into its core logic. Chapter 1 is an overview of two types of spatial phenomena, Turing patterns and trigger waves, in which a relatively simple mathematical model is able to capture the most salient characteristics of the spatial pattern. Chapter 2 details how trigger waves of mitotic activity help to spatially coordinate the events of mitosis across the relatively large Xenopus laevis egg. We present a simple mathematical model that shows the plausibility of such waves, as well as a detailed experimental study on the existence and dynamics of such waves in Xenopus eggs and extracts. In Chapter 3, I discuss methods that greatly enhance the ability to visualize Xenopus extract using fluorescence microscopy. Traditional methods are only able to visualize a fixed cell cycle state or a single transition from one state to another. The method presented takes advantage of the fact that Xenopus extracts execute many more cell cycles on Teflon versus other materials such as glass and polydimethylsiloxane (PDMS). Using a Teflon-coated glass coverslip, we were able to achieve high-resolution imaging using spinning disk confocal microscopy on extracts that can execute multiple (about six at a minimum) cell cycles.
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  • Positive and negative feedback loops are two of the most ubiquitous network motifs in biological systems. When a positive feedback loop and a negative feedback loop are coupled together, rich dynamics can emerge. Among these, oscillations in time and space, and pulses of protein activity are some of the commonly observed phenomena in a biological system. In this thesis, we started by computationally study the benefit of a positive feedback in an oscillator, and concluded that oscillators running on interlinked positive-and-negative feedback loops are more robust and tunable in period than the oscillators with only the negative feedback. We then focused on the Xenopus laevis embryonic cell cycle oscillator, a well characterized biochemical oscillator that runs on interlinked positive-and-negative feedback loops. We identified a transition of oscillator topology during Xenopus early development, from the long first cell cycle that depends critically on Wee1/Cdc25 mediated positive feedback, to the short subsequent cell cycles in which the positive feedback is dispensable. Using the human neutrophil-like HL60 cells, we studied the spatiotemporal dynamics of cytoskeleton proteins. We identified a perfect coupling between the protruding front and the retracting rear of a migrating HL60 cells. Myosin exhibits dynamic flashes at the rear of the cell, and the time scale of the flashes depends on local positive and negative feedback loops. When the duration of the myosin flashes is perturbed, the cell exhibits difficulties in turning and has inefficient chemotaxis. We also performed a statistical study comparing the shape and migration dynamics of HL60 cells, and provided evidence of a close correlation between the two phenotypes. Our results showed that the spatiotemporal protein dynamics allowed by proper regulation of interlinked positive-and-negative feedback loops is important in many examples in biology.
  • This volume is a cutting-edge review of the latest findings on key scientific and clinical issues in hypertension, with an integration of different new specific topics into the general knowledge of how to understand the pathophysiology and correctly diagnose and treat this chronic condition, which still represents the first cause of death in the world.Among the topics included in the book the reader will find some forms of hypertension which are frequently encountered in clinical practice and on which new important evidence is available, such as high-normal blood pressure (also termed pre-hypertension), white-coat and masked hypertension, and high blood pressure in the elderly and the very elderly. These emerging aspects are discussed in detail, along with chapters on issues of great current interest, such as the way to assess and how to treat asymptomatic organ damage, emerging cardiovascular risk factors such as short and long-term blood pressure variability, cognitive impairment and dementia. The book also deals with the changing concepts in the management of hypertension and antihypertensive pharmacotherapy, and addresses specific topics which are rarely discussed in clinical medicine volumes, including hypertension in post-menopausal women, hormonal replacement therapy, inflammatory disorders, sexual dysfunction with treatment, and the effect of Ramadan fasting on blood pressure. This ready to hand but encompassing volume proves to be a comprehensive updating tool to professionals and clinical practitioners managing patients with hypertension.
  • Special Procedures in Foot and Ankle Surgery is designed for foot and ankle surgeons who desire to take their skill set to the next level. Advanced surgical techniques are highlighted for some of the more difficult problems encountered by foot and ankle surgeons such as Charcot deformity, chronic tendinopathies, osteochondral lesions, total ankle arthroplasty, tumors, adult flatfoot, cavus and Rheumatoid foot. The latest techniques, including endoscopic approaches are highlighted. This book is designed for all levels of foot and ankle surgeons to better care for their patients.
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    Pattern recognition by B cells: the role of antigen repetitiveness versus toll-like receptors -- The multifunctional role of antibodies in the protective resonse to bacterial T cell-independent antigens -- The important anddiverse roles of antibodies in the host response to Borrelia infections -- A distinct role for B1b lymphocytes in T cell-independent immunity -- Secretory immunity following mutans streptococcal infection or immunization.
  • 1. What We Know About Factors Affecting Medical Student & Resident Career Decisions -- 2. Study Aims, Questions, Methods, Limitations -- 3. Outcomes of Current Physician Training -- 4. Debt -- 5. Title VII Effect, Personal Interests, and Experiences in Medical School -- 6. Return on Investment -- 7. Conclusions and Recommendations -- Appendices.
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    This illustrated reference is a practical guide to the use of arthrography in conjunction with MRI and CT for accurate diagnosis of musculoskeletal injuries and diseases. The opening general principles section includes chapters on arthrographic appearance of arthritides, basic techniques, therapeutic injections, tenosynography, and ultrasound-guided aspiration. Subsequent sections focus on the shoulder, elbow, wrist, hip, sacroiliac joint, knee, ankle, and foot. Each section includes an explanation of arthrographic procedures and pitfalls; an atlas of relevant articular anatomy; diagnostic criteria and differential diagnoses for specific injuries and diseases; and a chapter on postoperative findings. The format features succinct, bulleted text and hundreds of illustrations with detailed legends.
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    Also available: Print – v. 1-2., 1895-
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    In this comprehensive work, John S. Wilkins traces the history of the idea of "species" from antiquity to today, providing a new perspective on the relationship between philosophical and biological approaches.--[Book cover].
  • This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: Gene expression in colon cancer tissue Epigenetics in human acute kidney injury Embryologically relevant candidate genes in MRKH patients DNA methylation in common skeletal disorders Causal relat.
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    v. 1. Bacterial, fungal, parasitic.
  • The systems-based approach to proteomics and chemical proteomics / Daniel S. Sem -- Similarities in protein binding sites / Hugo O. Villar, Mark R. Hansen, and Richard Kho -- Survey of spectral techniques used to study proteins / Daniel S. Sem -- Capillary electrophoresis, mass spectrometry for characterization of peptides and proteins / Christian Neusüss and Matthias Pelzing -- Protein and peptide analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (Maldi MS/MS) / Emmanuelle Sachon and Ole Nørregaard Jensen -- Characterization of glycosylated proteins by mass spectrometry using microcolumns and enzymatic digestion / Per Hägglund and Martin R. Larsen -- Surface-enhanced laser desorption/ionization protein biochip technology for proteomics research and assay development / Scot R. Weinberger ... [et al.] -- An approach to the reproducibility of SELDI profiling / Walter S. Liggett ... [et al.] -- Mass spectrometric applications in immunoproteomics / Anthony W. Purcell ... [et al.] -- Near-infrared fluorescence detection of antigen-antibody interactions on microarrays / Sakanyan Vehary and Yeretssian Garabet -- Application of shotgun proteomics to transcriptional regulatory pathways / Amber L. Mosley and Michael P. Washburn -- Electrophoretic NMR of protein mixtures and its proteomic applications / Qiuhong He, Sunitha B. Thakur, and Jeremy Spater -- Characterizing proteins and proteomes using isotope-coded mass spectrometry / Uma Kota and Michael B. Goshe -- Surface plasmon resonance biosensors’ contributions to proteome mapping / Rebecca L. Rich and David G. Myszka -- Application of in-cell NMR spectrocopy to investigation of protein behavior and ligand-protein interaction inside living cells / Volker Dötsch -- An overview of metabonomics techniques and applications / John C. Lindon, Elaine Holmes, and Jeremy K. Nicholson -- NMR-based structural proteomics / John L. Markley -- Leveraging x-ray structural information in gene family-based drug discovery: application to protein kinases / Marc Jacobs ... [et al.] -- EPR spectroscopy in genome-wide expression studies / Richard Cammack -- Summary of chapters and future prospects for spectral techniques in proteomics / Daniel S. Sem.
  • v. 2, 2006 Springer
    v. 3, 2006 Springer
    v. 4, 2006 Springer
    v. 5, 2006 Springer
    v. 6, 2006 Springer
    v. 1. Cholestanes, ergostanes, withanolides, stigmastane -- v. 2. Stigmastanes, furostanes, spirtostanes-- v. 3. Spirostanes, bufanolides, cardenolides-- v. 4. Cardenolides and pregnanes -- v. 5. Pregnanes, androstanes, and miscellaneous -- v. 6. Miscellaneous steroids and indexes.
  • Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage.
  • No evidence for killer sperm or other selective interactions between human spermatozoa in ejaculates of different males in vitro (1999) / Harry D.M. Moore, M. Martin & Tim R. Burkhead -- Psychological adaptation to human sperm competition (2002) / Todd K. Shackelford ... [et al.] -- Semen displacement as a sperm competition strategy in humans (2004) / Gordon G. Gallup & Rebecca L. Burch -- Human female orgasm and male fluctuating asymmetry (1995) / Randy Thornhill, Steve W. Gangestad & Randall Comer. Sperm competition in humans / Nicholas Pound, Todd K. Shackelford, Aaron T. Goetz -- Why are there so many tiny sperm? Sperm competition and the maintenance of two sexes (1982) / Geoffrey A. Parker -- Sperm competition, male prudence, and sperm-limited females (2002) / Nina Wedell, Matthew J.G. Gage & Geoffrey A. Parker -- Human sperm competition (1984) / Robert L. Smith -- "Kamikaze" sperm in mammals? (1988) / R. Robin Baker & Mark A. Bellis -- Deformed sperm are probably not adaptive (1989) / Alexander H. Harcourt -- Elaboration of the kamikaze sperm hypothesis: a reply to Harcourt (1989) / R. Robin Baker & Mark A. Bellis -- Number of sperm in human ejaculates varies in accordance with sperm competition theory (1989) / R. Robin Baker & Mark A. Bellis -- Do females promote sperm competition? Data for humans (1990) / Mark A. Bellis & R. Robin Baker -- Human sperm competition: ejaculate adjustment by males and the function of masturbation (1993) / R. Robin Baker & Mark A. Bellis -- Human sperm competition: ejaculate manipulation by females and a function for the female orgasm (1993) / R. Robin Baker & Mark A. Bellis --
  • Also available: Print – v. 1., 1911-
  • Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • Also available: Print – 2011
    Sphingolipid metabolism and analysis in metabolic disease / Sarah E. Brice and L. Ashley Cowart -- Sphingolipids and cardiovascular diseases : lipoprotein metabolism, atherosclerosis and cardiomyopathy / Xian Cheng Jiang, Ira J. Goldberg, and Tae Sik Park -- Heart sphingolipids in health and disease / Marcin Baranowski and Jan Grski -- Blood sphingolipids in homeostasis and pathobiology / Samar M. Hammad -- Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity / Fahumiya Samad ... [et al.] -- Sphingolipids and hepatic steatosis / Benjamin T. Bikman and Scott A. Summers -- Glycosphingolipids and insulin resistance / Johannes M. Aerts ... [et al.] -- Glycosphingolipids and kidney disease / Andrew R. Mather and Leah J. Siskind -- Sphingolipid synthetic pathways are major regulators of lipid homeostasis / Tilla S. Worgall.
  • Also available: Print – 2010
    An overview of sphingolipid metabolism : from synthesis to breakdown / Christopher R. Gault, Lina M. Obeid, and Yusuf A. Hannun -- Sphingolipid transport / Laura Riboni, Paola Giussani and Paola Viani -- Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) / Jacek Bielawski ... [et al.] -- Ceramide synthases : roles in cell physiology and signaling / Johnny Stiban, Rotem Tidhar and Anthony H. Futerman -- Tales and mysteries of the enigmatic sphingomyelin synthase family / Joost C.M. Holthuis and Chiara Luberto -- Ceramide in stress response / Mariana N. Nikolova-Karakashian and Krassimira A. Rozenova -- Animal models for studying the pathophysiology of ceramide / Toshihiko Kawamori -- Ceramide 1-phosphate in cell survival and inflammatory signaling / Antonio Gómez-Muñoz ... [et al.] -- Ceramide-1-phosphate in phagocytosis and calcium homeostasis / Vania Hinkovska-Galcheva and James A. Shayman -- Extracellular and intracellular actions of sphingosine-1-phosphate / Graham M. Strub ... [et al.] -- Glucosylceramide in humans / Maria C. Messner and Myles C. Cabot -- Gangliosides as regulators of cell membrane organization and functions / Sandro Sonnino and Alessandro Prinetti -- Cancer treatment strategies targeting sphingolipid metabolism / Babak Oskouian and Julie D. Saba -- Therapeutic strategies for diabetes and complications : a role for sphingolipids? / Todd E. Fox and Mark Kester -- Roles for sphingolipids in Saccharomyces cerevisiae / Robert C. Dickson -- Sphingolipid signaling in fungal pathogens / Ryan Rhome and Maurizio Del Poeta -- Sphingolipids in parasitic protozoa / Kai Zhang, James D. Bangs and Stephen M. Beverley -- Biosynthesis of sphingolipids in plants (and some of their functions) / Simone Zäuner, Philipp Ternes, and Dirk Warnecke -- Computational analysis of sphingolipid pathway systems / Eberhard O. Voit, Fernando Alvarez-Vasquez, and Yusuf A. Hannun.
  • Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • Also available: Print – 2014
    "This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses."--Publisher's website.
  • Spine systems science : a primer on the systems approach / N. Peter Reeves, Jacek Cholewicki -- Computational models for trunk trajectory planning and load distribution : a test-bed for studying various clinical adaptation and motor control strategies of low back pain patients / Mohamad Parnianpour -- Mechanical changes in the spine in back pain / Greg Kawchuk -- Spine function and low-back pain : interactions of active and passive structures / Jaap H. van Dieen, Idsart Kingma -- Adaptation and rehabilitation: from motoneurones to motor cortex and -- Behaviour / Paul W. Hodges -- Opinions on the links between back pain and motor control : the disconnect -- Between clinical practice and research / Stuart McGill -- The kinesiopathologic model and mechanical low back pain / Linda R. Van Dillen, Shirley A. Sahrmann, Barbara J. Norton -- The relationship between control of the spine and low back pain : a clinical -- Researcher's perspective / Julie A. Hides -- Existing muscle synergies and low back pain : a case for preventative -- Intervention / Jack P. Callaghan, Erika Nelson-Wong -- Trunk muscle control and back pain : chicken, egg, neither or both? / G. Lorimer Moseley -- Altered variability in proprioceptive postural strategy in people with recurrent low back pain / Simon Brumagne ... [et al.] -- Proprioceptive contributions from paraspinal muscle spindles to the relationship between control of the trunk and back pain / Joel G. Pickar -- Time-dependent mechanisms that impair muscle protection of the spine / Patricia Dolan, Michael A. Adams -- Effectiveness of exercise therapy for chronic non-specific low-back pain / Marienke van Middelkoop .... [et al.] -- How can models of motor control be useful for understanding low back pain? (summary chapter 1) / N. Peter Reeves ... [et al.] -- Targeting interventions to patients : development and evaluation (summary chapter 2) / Linda van Dillen, Maurits van Tulder -- Motor control changes and low-back pain, cause or effect? (summary chapter 3) / Jaap H. van Dieen, G. Lorimer Moseley, Paul W. Hodges -- What is the relation between proprioception and low back pain? (summary chapter 4) / Simon Brumagne, Patricia Dolan, Joel G. Pickar -- Motor control of the spine and changes in pain : debate about the extrapolation from research observations of motor control strategies to effective treatments for back pain (summary chapter 5) / Paul W. Hodges, Stuart McGill, Julie A. Hides -- Integrated clinical approach to motor control interventions in low back and pelvic pain / Paul W. Hodges ... [et al.].
  • The organization of the spinal cord / Charles Watson and Gulgun Kayalioglu -- Development of the spinal cord / Kens WS Ashwell -- The vertebral column and spinal meninges / Gulgun Kayalioglu -- The spinal nerves / Gulgun Kayalioglu -- The spinal cord blood vessels / Oscar U. Scremin -- Cytoarchitecture of the spinal cord / Claire Heise and Gulgun Kayalioglu -- Localization of motoneurons in the spinal cord / Steve McHanwell and Charles Watson -- Spinal autonomic preganglionic neurons: the visceral efferent system of the spinal cord / Colin R. Anderson, Janet R. Keast and Elspeth M. McLachlan -- Central nervous system control of micturition / Gert Holstege and Han Collewijn -- Projections from the spinal cord to the brain / Gulgun Kayalioglu -- Projections from the brain to the spinal cord / Charles Watson and Alan R. Harvey -- The propriospinal system / Amanda C. Conta and Dennis J. Stelzner -- Spinal cord transmitter substances / Claire Heise and Gulgun Kayalioglu -- Spinal cord injury: experimental animal models and relation to human therapy / Stuart I. Hodgetts, Giles W. Plant and Alan R. Harvey -- Atlas of the rat spinal cord / Charles Watson ... [et al.] -- Atlas of the mouse spinal cord / Charles Watson ... [et al.] -- Toward a spinal cord ontology / Charles Watson and Amandeep Sidhu.
  • Presents authorataive coverage of state-of-the-art techniques for diagnosing and managing tumors of the spine and spinal cord. Covers fundamentals of spinal cord anatomy and the pathology of spinal tumors to evaluation, diagnosis, and treatment techniques for specific spinal tumors.
  • Spinal cord injury 2012
    Spinal Cord Injuries, the newest volume in the Handbook of Clinical Neurology series, offers a comprehensive and detailed overview of the rapidly evolving science and treatment of spinal cord injury. Advances in neuroimaging, surgical treatment and application of electrical stimulation are dramatically impacting the treatment and outcome of these injuries. It provides a clear introduction to the core science of spinal cord injury, as well as to exciting research investigating new treatment options. Coverage includes brain-machine interfaces, transcranial stimulation, new pharmacological strategies, use of olfactory ensheathing cells, stem cells and precursor cells, gene therapy and molecular target discovery. This volume is a great resource for neuroscience and clinical neurology research specialists and practicing neurologists seeking a clear reference to the science and treatment of spinal cord injury. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities .
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    Section I. Spinal cord injuries in patients -- Section II. Spinal cord injuries in animal models -- Section III. Neuroprotection and transplantation -- Section IV. Molecular targets to promote axon regeneration in the CNS.
  • 1. The History and Overview of Spinal Deformity -- 2. Measuring Value in Spinal Deformity Care -- 3. Intraoperative Neuromonitoring in Spinal Deformity Surgery -- 4. Anatomy and Evaluation of Spinal Alignment -- 5. Anatomical Variants with Spinal Deformity -- 6. The Importance of the Sacrum and Pelvis in Deformity Evaluation and Treatment -- 7. The Lenke Classification System for Adolescent Idiopathic Scoliosis -- 8. Principles of Sagittal Plane Deformity -- 9. Principles of Coronal Plane Deformity -- 10. Flexible versus Fixed Spinal Deformity -- 11. The Natural History of Spinal Deformity -- 12. Congenital Scoliosis -- 13. Early-Onset Scoliosis -- 14. Neuromuscular Scoliosis -- 15. Anterior Surgery for Thoracic Scoliosis -- 16. Posterior Approach in Thoracic Deformity -- 17. Lateral Interbody Fusion Approaches in Spinal Deformity -- 18. Anterior-Posterior Surgery for Spinal Deformity -- 19. Minimally Invasive Surgery for Adult Spinal Deformities -- 20. Scheuermann Kyphosis -- 21. Technological Advances in Spinal Deformity -- 22. Surgery for Adult Spinal Deformity -- 23. Osteotomies and Vertebral Column Resections for Complex Spinal Deformities -- 24. Adult Spinal Deformity Revision Surgery -- 25. Surgical Treatment of Spondylolisthesis -- 26. Prevention and Treatment of Posttraumatic Deformity of the Thoracolumbar Spine -- 27. Bracing and Nonoperative Treatment of Spinal Deformity.
  • Spinal imaging 2008
    Thieme Book
    1. Congenital malformations -- Arnold-Chiari malformation -- Lumbarization and sacralization -- Diastematomyelia -- Tethering -- Sacrococcygeal teratoma -- Meningocele, myelomeningocele -- Vertebral malformations -- Klippel-Feil syndrome -- Kyphosis -- Scheuermann disease -- Scoliosis -- Malrotation -- 2. Trauma -- Spinal injury-magerl classification -- Vertebral fractures-causes -- Dens fracture -- Flexion fracture of the cervical spine -- Burst fracture of the spine -- Chance fracture (seat belt fracture) -- Jefferson fracture -- Hangmans's fracture -- Spinal cord trauma -- Syringohydromyelia -- Anterior subluxation -- Insufficiency fracture of the sacrum -- Stress phenomena in the spine -- Stress fractures in ankylosing spondylitis -- 3. Degenerative disorders -- Disk degeneration -- Degenerative disk disease modic I -- Degenerative disk disease modic II -- Spondylosis deformans-modic III -- Disk herniation -- Bulge, protrusion, extrusion, sequestration -- Disk calcification and vacuum phenomenon -- Facet joint degeneration -- Uncovertebral osteoarthritis -- Synovial cyst -- Hypertroply of the ligamenta flava -- Baastrup disease -- Spongylolisthesis and pseudospondylolisthesis -- Degenerative spinal stenosis -- Diffuse idiopathic skeletal hyperostosis -- 4. Inflammatory disorders -- Rheumatoid arthritis -- Rheumatoid arthritis-chronic trauma -- Psoriatic spondyloarthropathy -- Reiter syndrome -- Ankylosing spondylarthropathy -- Ankylosing spondylitis-ligament calcification and bamboo spine -- Ankylosing psondylitis-fractures --Acute bacterial spondylitis -- Tuberculous spondylitis -- Epidural abscess -- Granulomatous inflammations of the spinal cord -- Arachnoiditis -- Acute transverse myelitis -- Spinal Multiple sclerosis --; 5. Tumors -- Hemangioma -- Osteoid osteoma -- Osteoblastoma -- Osteochondroma -- Aneurysmal bone cyst -- Giant cell tumor -- Langerhans cell histiocytosis -- Malignant tumors -- Bone metastases -- Multiple myeloma -- Chordoma -- Ewing sarcoma -- Lymphoma -- Nerve sheath tumors -- Leptomeningeal and intramedullary metastases -- Meningioma -- Ependymoma -- Astrocytoma -- Hemangioblastoma -- 6. Vascular disorders -- Epidural hematoma -- Arteriovenous malformation -- Arterial spinal cord infarction -- 7. Postoperative disorders -- Failed back surgery syndrome -- CSF fistula -- Peridural fibrosis -- Rapidly progressive osteoarthritis (after intersegmental fusion) -- Complications of spinal instrumentation -- 8. Metabolic disorders -- Senile and postmenopausal osteoporosis -- Paget disease -- Spinal epidural lipomatosis.
  • Spinal injection techniques 2009
    Thieme eNeurosurgery
    1. Basic principles -- 2. Diagnostics -- 3. Causal orthopedic pain therapy -- 4. Symptomatic pain therapy -- 5. The spine : anatomy, nociception, and the distribution of pain signals -- 6. Special orthopedic injection therapy : contraindications and patient information -- 7. Cervical injection therapy -- 8. Thoracic injection therapy -- 9. Lumbar injection therapy -- 10. General and specific complications and treatment measures -- 11. Multimodal spinal therapy -- 12. Summary.
  • Sect. I. General considerations. 1. History of spine injections / Sheryl L. Johnson and Kevin E. Vorenkamp -- 2. Therapeutic agents for spine injection: local anesthetics, steroids, and contrast media / Matthew J. Pingree and Marc A. Huntoon -- 3. Fluoroscopy, ultrasonography, computed tomography, and radiation safety / Stanley Golovac -- Sect. II. Peripheral nerve blocks. 4. Differential diagnostic nerve blocks / Jerald Garcia, I. Elias Veizi, and Salim M. Hayek -- 5. Head and neck blocks / Samer Narouze -- 6. Upper extremity peripheral nerve blockade / Hugh M. Smith and Christopher M. Duncan -- 7. Lower limb blacks / Padraig Mahon and Colin J.L. McCartney -- 8. Cervical and lumbar sympathetic blocks / Samer Narouze and Sean Graham -- 9. Nerve destruction for the alleviation of visceral pain / Kacey A. Montgomery and Robert W. Hurley -- 10. Peripheral applications of ultrasonography for chronic pain / Philip Peng -- Sect. III. Injections for back pain. 11. Therapeutic epidural injections: interlaminar and transoraminal / Marc A. Huntoon and Abram H. Burgher -- 12. Facet (zygapophyseal) intraarticular joint injections: cervical, lumbar, and thoracic / Jason E. Pope and Jianguo Cheng -- 13. Medial branch blocks: cervical, thoracic, and lumbar / Seth A. Waldman, Vinita Parikh, and Dawood Sayed -- 14. Radiofrequency rizotomy for facet syndrome / Jan van Zundert ... [et al.] -- 15. Sacroiliac joint injections and lateral branch blocks, including water-cooled neurotomy / Bryan S. Williams -- 16. Pulsed radiofrequency / Khalid Malik and Honorio T. Benzon -- 17. Discogenic pain and discography for spinal injections / Stanley Golovac -- 18. Minimally invasive intradiscal procedures for the treatment of discogenic lower back and leg pain / Leonardo Kapural and Dawn A. Sparks -- 19. Vertebral augmentation / Tristan C. Pico, Basem Hamid, and Allen W. Burton -- 20. Ultrasound-guided lumbar spine injections / Manfred Greher -- 21. Ultrasound-guided cervical spine injections / Samer Narouze -- 22. Musculoskeletal injections: iliopsoas, quadratus lumborum, piriformis, and trigger point injections / Anne Marie McKenzie-Brown, Kiran Chekka, and Honorio T. Benzon -- 23. Ultrasound-guided and fluoroscopically guided joint injections / Steve J. Wisniewski and Mark-Friedrich B. Hurdle.
  • Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.
  • Spinal instability 2015
    This easy-to-consult guide describes new minimally invasive procedures for the treatment of spinal instability that are accompanied by fewer complications and side-effects, reduce the risks of anesthesia, and lower costs. Clear accounts of a range of CT, X-ray, and MRI guided techniques are provided, including radiofrequency ablation in facet syndrome, cervical spine fusion, posterior and anterior lumbar spine fusion, and lumbosacral fusion. A brief but comprehensive introduction is included on biomechanics, relevant clinical syndromes, and diagnostic imaging. Like other books in the Springer series New Procedures in Spinal Interventional Neuroradiology, this practice-oriented volume will fill a significant gap in the literature and meet the need expressed by a large number of specialists (interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists) for a topical and handy guide that specifically illustrates the presently available materials and methods.
  • Provides a complete guide to all contemporary forms of spinal implant systems. It not only highlights the newest devices, but also the clinical guidelines needed to choose and apply the best implant for any surgical situation. Along with an all-inclusive list of the spinal instruments available today, the book offers direct comparisons of each system to help make an informed and confident selection. Includes valuable tips on insertion techniques and complication avoidance to maximize success in the operating room. And, thousands of graphics ensure a lucid understanding of all implants and their applications.
  • Spinal osteotomy 2015
    Spinal osteotomy techniques have been dramatically applied as a standard method for severe and rigid spinal deformity. Although clinical results indicate that patients who undergo osteotomy procedures typically experience well deformity correction and ameliorate the clinical appearance, aggressive peri-operative risks and follow-up complications are not rare. More meticulous and standard indication selection, osteotomy plan design and complication prevention strategy and outcome evaluation are critically needed for surgeon majored in spine deformity. The book Spinal Osteotomy is divided into sections that focus on principles of spinal osteotomy, technical and case illustration and outcomes and complications as well as computer navigation and other latest techniques. Each section is heavily illustrated and clearly written for ease of understanding. Orthopedic surgeons, neurosurgeon residents and fellows who want to focus on spinal deformity correction will find this instructive and invaluable. Editor Yan Wang is a professor and dean of orthopedics department, Chinese PLA general hospital, China. Oheneba Boachie-Adjei, MD, is Chief of the Scoliosis Service, Hospital for Special Surgery, New York, NY, USA. Lawrence G. Lenke MD, is Professor and Chief of the Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
  • Pathophysiology of spinal cord injury / B. Timothy Himes -- The neurological evaluation and medical management of acute spinal cord injury / Anthony S. Burns and Ralph J. Marino -- Surgical treatment of spinal injury / Daniel R. Fassett and James S. Harrop -- Controversies in clearing the spine / C. Craig Blackmore and Ken F. Linnau -- Plain film radiography and computed tomography of the cervical spine. Part I. Normal anatomy and spinal injury identification / Alejandro Zuluaga Santamaria and Diego B. Núñez, Jr. -- Plain film radiography and computed tomography of the cervical spine. Part II. Classification and subtypes of spinal injury / Alejandro Zuluaga Santamaria and Diego B. Núñez, Jr. -- Imaging of thoracolumbar spinal injury / George Koulouris, Amy Y.I. Ting, and William B. Morrison -- Magnetic resonance imaging of acute spinal trauma / Adam E. Flanders -- Imaging of pediatric spinal trauma / Avrum N. Pollock and Stephen M. Henesch -- Postoperative spinal imaging / Ashwini D. Sharan, Hana Choe, and Laura Snyder -- Imaging of the previously injured spinal cord / Steven Falcone -- Experimental therapies for spinal cord injury / Marion Murray -- Experimental techniques of spinal imaging / Eric D. Schwartz.
  • Offers information needed to maximize the potential of ultrasound in daily practice. Topics include nephrology, urology, the urogenital tract in the child, non-ultrasound imaging of the urogenital tract, oncological management of tumors of the urogenital tract, and more.
  • Evidence-based medicine: outcomes assessment -- Fundamental principles and clinical assessment -- Imaging -- Problem-based approach to the principles of spinal injury management -- Upper cervical injuries and their management -- Subaxial cervical spine injuries and their management -- Thoracolumbar spine injuries and their management -- Rehabilitation following spinal injury and late complications -- Emerging techniques and translational research
  • 1. Spine classification systems to spine disease severity measures : a paradigm shift -- 2. Method for identifying and evaluating spine severity measures -- 3. What makes a quality severity measure? -- 4. How the severity measures are displayed in this book -- 5. Spine disease severity measures -- 6. Spine trauma severity measures -- 7. Going beyond classification systems : new horizons for adolescent idiopathic scoliosis.
  • Print Material
  • Also available: Print – 2014
  • Print Material
  • Outcomes instruments that attempt to assess the function and quality of life in patients suffering from various spine conditions are on the increase. This book sets out to evaluate and summarize over 100 outcomes instruments for the spine and its associated diseases.
  • Radiobiology of radiosurgery / Jae Ho Kim and Stephen Brown -- Clinical spinal cord tolerance to radiosurgery / Simon S. Lo [and 10 others] -- Management of spinal cord toxicity / Samuel Ryu, Steve Brown, and Jae Ho Kim -- Histopathologic examination of spinal lesions after radiosurgery / Nathan T. Zwagerman [and 6 others] -- Stereotactic spine radiotherapy : image guidance and patient immobilization / Max Dahele and Ben Slotman -- Treatment planning for spine radiosurgery / David Schlesinger, K. Martin Richardson, Kelly M. Spencer, Brian Winey, and Jason Sheehan -- Quality assurance and treatment delivery / Fang-fang Yin, Zheng Chang, and Justus Adamson -- Contemporary devices for spinal radiosurgery / Christoph Fürweger [and 5 others] -- Imaging, target delineation, and dose prescription / Eric Chang, Omar Ragab, Sukhjeet Batth, Shelly Bian, and Lydia Nng -- Radiosurgery for the re-treatment of progressive spine metastases / Andrew A. Kanner and Benjamin W. Corn -- Clinical outcomes after spinal radiosurgery / Peter C. Gerszten and John C. Flickinger -- Clinical outcomes of pain and quality of life after spinal radiosurgery / Lily Angelov, Sam Chao, and John Suh -- Radiosurgery for spinal canal compromise and spinal cord compression / Richard A. Rammo, Ian Y. Lee, Jack P. Rock, and Samuel Ryu -- Postoperative radiosurgery and minimally invasive surgical techniques / Tobias A. Mattei [and 7 others] -- Radiosurgery and percutaneous cement augmentation / Michael Decuypere and Jason A. Weaver -- Treatment failure, complications, and their management / Nicolaus Andratschke and Matthias Guckenberger -- Patient evaluation and treatment selection for spinal canal compromise / Samuel Ryu and Mark Bilsky -- Radiosurgery for benign extramedullary tumors of the spine / Iris C. Gibbs, Navjot Chaudhary, Steven D. Chang, Robert L. Dodd, and John R. Adler, Jr -- Radiosurgical treatment of spinal chordomas / James P. Caruso, Mark H. Bilsky, Josh Yamada, and Ilya Laufer -- The role of radiosurgery in the treatment of primary malignant spine and spinal cord tumors / Moon-Jun Sohn, Dong-Joon Lee, and Hye-Ran Lee -- Radiosurgery for spinal cord arteriovenous malformations / Maziyar A. Kalani, Iris C. Gibbs, John R. Adler, Jr., and Steven D. Chang -- Multidisciplinary approach for the evaluation and treatment of metastatic spinal tumors / Ganesh M. Shankar, Kevin Oh, Kristina Shultz, and John H. Shin.
  • Spine. 3rd ed. v. 1-2, 1992.
    Print Material
  • Spine secrets plus. 2nd ed. 2012
    2012 ClinicalKey
  • Fully revises second edition, keeping its focus on presenting surgical techniques of both common and uncommon procedures written by prestigious contributing specialists, and maintaining its approach of demonstrating step-by-step surgical instructions, including tips, pearls, pitfalls and "rescues", making this new edition an even more invaluable resource and guide for all those operating on the spine. Includes new chapters on minimally invasive exposure and fixation techniques of posterior spine, percutaneous cement augmentation techniques (including vertebroplasty and kyphoplasty), and bone grafting and reconstruction.

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