• 2009From: Springer
    collection dirigeé par Marc Immenroth, Thorsten Berg, Jürgen Brenner ; auteurs, Gérard Champault, Hendrik Schimmelpenning ; avec le conours de Ann-Katrin Güler, Ute Stefani Haaga.
  • 2015From: Springer
    Changming Sun, Tomasz Bednarz, Tuan D. Pham, Pascal Vallotton, Dadong Wang, editors.
    Signal and image analysis techniques are becoming more widely used in biomedical and life science applications. With an emphasis on applications of computational models for solving modern challenging problems in biomedical and life sciences, this book aims to bring collections of articles from biologists, medical/biomedical and health science researchers together with computational scientists to focus on problems at the frontier of biomedical and life sciences. The goals of this book are to build interactions of scientists across several disciplines and to help industrial users apply advanced computational techniques for solving practical biomedical and life science problems. This book is for users in the fields of biomedical and life sciences who wish to keep abreast with the latest techniques in signal and image analysis. The book presents a detailed description to some of the applications. It can be used by those both at graduate and specialist levels.
    Also available: Print – 2015
  • 2010From: ScienceDirect
    Wim van Drongelen.
    Lomb's algorithm and the Hilbert transform -- Modeling -- Volterra series -- Wiener series -- Poisson-Wiener series -- Decomposition of multichannel data -- Causality.
  • 2010From: CRCnetBASE
    Dževad Belkić, Karen Belkić.
    Chapter 1. Basic Tasks of Signal Processing in Spectroscopy -- Chapter 2. The Role of Quantum Mechanics in Signal Processing -- Chapter 3. Exact Quantum-Mechanical, Pade-Based Recovery of Spectral Parameters -- Chapter 4. Harmonic Transients in Time Signals -- Chapter 5. Signal-Noise Separation via Froissart Doublets -- Chapter 6. Machine Accurate Quantification and Illustrated Signal-Noise Separation -- Chapter 7. Pade Processing for MR Spectra from In Vivo Time Signals -- Chapter 8. Magnetic Resonance in Neuro-Oncology -- Chapter 9. Pade Quantification of Malignant and Benign Ovarian MRS Data -- Chapter 10. Breast Cancer and Non-Malignant Breast Data -- Chapter 11. Multiplet Resonances in MRS Data from Normal and Cancerous Prostate -- Chapter 12. Recapitulation of Pade-Optimized Processing of Biomedical Time Signals.
  • Charles S. Lessard.
  • 2010From: Springer
    edited by Ari Sitaramayya.
  • 2011From: Springer Protocols
    edited by Alexander E. Kalyuzhny.
    Unlike detecting constitutively expressed targets, immunohistochemical detection of labile, low abundance, and short-lived signal transduction molecules can be a very difficult task. In Signal Transduction Immunohistochemistry: Methods and Protocols, IHC experts contribute detailed protocols addressing the numerous challenges of signal-transduction immunohistochemistry (ST-IHC). Beginning with a set of introductory chapters, the volume moves on to cover techniques used for the preservation of antigens and their unmasking, protocols in digital imaging and image analysis of stained cells and tissues, high-throughput data collection and data analysis, and techniques used in neuroscience as well as cancer and stem cell research. Written in the highly successful Methods in Molecular Biology series format, chapters include brief introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Signal Transduction Immunohistochemistry: Methods and Protocols serves as an ideal guide for novices and as a bastion of inspiring ideas to be exploited by experienced researchers on the lookout for new experimental tricks and hints.
  • 2010From: Springer
    edited by Wen-Sheng Wu and Chi-Tan Hu.
    "The poor prognosis and high mortality for cancer patients are majorly ascribed to tumor metastasis, one of the most complicated pathological processes. Elucidation of molecular mechanisms for metastasis is essential for management and prevention of this lethal condition. In the book to be published, we take comprehensive review in regard with the signal mechanisms responsible for triggering a series of phenotypical changes of primary tumor which may lead to final colonization of the tumor in a second home. Specifically, the initial stage of tumor metastasis will be highlighted. The complex tumor microenvironment accumulate a lot of growth factors, inflammatory cytokines and extracellular matrix which may turn into a group of potent metastatic factors. An integrated and sustained signaling induced by these metastatic factors may trigger EMT, migration and invasion of primary tumor into surround tissue. Blockade of these signal pathways is the most effective approach for prevention of tumor metastasis. A lot of clinical trials are under way for this purpose and the outcome are promising. The expert reviews compiled in this book may encourage the researcher in this exciting field for future study."--Back cover
  • Chieh-Yu Lin.
    The cardiovascular system provides blood circulation throughout the body and is essential for our survival. The major components of the circuitry--the heart, the valves, and the vasculature--require precise signaling events for their prenatal morphogenesis and postnatal homeostasis. Here, we describe the role of cell signaling in cardiovascular biology. In the arterial system, VEGF/Vegfr-2 signaling is essential for vascular remodeling. A pulse of VEGF/Vegfr-2 signaling in the vascular adventitia within hours after vascular injury activates Sca1+ tissue stem cells to differentiate into adventitial and neointimal cells, forming the neointima that occludes the vessel. In the myocardium, calcineurin/NFAT signaling controls cardiac fiber orientation and the expression of dystrophin, a-dystrobrevin, and utrophin--components of the dystrophin glycoprotein complex frequently found abnormal in patients with Duchenne, Becker, or other muscular dystrophies. Deletion of calcineurin in the myocardium results in cardiomyopathy, a phenotype similar to that observed in Duchenne muscular dystrophy patients. In the secondary heart field, calcineurin/NFATc1 signaling is required for semilunar valve morphogenesis. Conditional ablation of calcineurin or NFATc1 causes regression of heart valve primordium, leading to complete absence of the aortic and pulmonic valves, severe valve regurgitation, and perinatal lethality. These studies demonstrate novel functions and molecular mechanisms of cell signaling in three facets of cardiovascular biology.
  • 2008From: Springer
    edited by Ashok K. Srivastava, Madhu B. Anand-Srivastava.
    G-protein-coupled receptor signaling -- Implication of G-proteins in cardiocascular diease / Madhu B. Anand-Srivastava -- B-adrenoceptor-linked signal transduction mechanisms in congestive heart failure / Melissa R. Dent...[et al.] -- Cardic G(alpha)s and G(alpha)i modualte sympathetic versus parasympathetic mechanisms on hyperhomocysteinemia / Thoma P. Vacek...[et al.] -- The role of the beta-adrenergic signal transduction pathway in myocardial protection / Johan Moolman...[et al.] -- Angiotensin II signaling in vascular physiology and pathophysiology / Neils Engberding, Kathy K. Greindling -- Angiotensin II signaling: cell growth and apoptosis / Stephen W. Shaffer, Mahmood S. Mozaffari -- Redox signaling -- Thioredoxin signaling in the ischemic heart / Dipak k. Das, Shyamal K. Goswami -- Relationship between redox regulation and B-adrenergic responses in the heart / Belma Turan -- Role of hyperglycemia and redox-induced signaling in vascular complications of diabetes / Ashok K. Srivastava, Madhu B. Anand-Srivastava -- Methylglyoxal and insulin resistance / Lingyun Wu -- Growth factor signaling -- Role of growth factor receptor transactivation in vasoactive peptide-induced signaling pathways in vascular smooth muscle cells / Ali Boullegue, Ashok K. Shrivastava -- Identifying the cellular and molecular events associated with the divergent phenotypes of cardic hypertrophy / Angelino Calderone -- Regulatory role of TGF-B in cardic myofibroblast function and post-MI cardic Fibosis: key roles of Smad7 and c-Ski / Ian M.C. Dixon...[et al.] -- The signaling duel between virus and host: Impact on Coxsackieviral Pathogenesis / Xiaonung Si...[et al.] -- Therapeutic angiogenesis and vasculogenesis for ischemic disease / Nilanjana Maulik -- VEGF signaling: a therapeutic target for cardiovascular disease / Dhanya Handrasekharan Rajalakshmi...[et al.] -- Myristoyl-CoA: protein N-Myristoyltransferase and Myristoyl-CoA binding protein from bovine cardiac muscle / Ponniah Selvakumar, Rajendra K. Sharma -- Calcium signaling -- Ca(2+)/calmodulin-dependent protein kinase II signaling in vascular smooth muscle / Suzanne J. House...[et al.] -- The KCa3.1 channel of endothelial cells as new target for EDHF-based control of cascular tone: from structure to regulation and pharmacological properties / Umberto Banderali...[et al.] -- Adipokine signaling -- Leptin signaling in the cardiovascular system / Morris karmazyn...[et al.] -- AMPK regulation of cardiac metabolism in heart disease / Ding An, Min-Suk Kim, Brian Rodigues.
  • 2008From: CRCnetBASE
    edited by Steven J. Fliesler and Oleg G. Kisselev.
  • 2009From: ScienceDirect
    Bastien D. Gomperts, Ijsbrand M. Kramer, Peter E.R. Tatham.
    "A reference on cellular-signalling processes, Signal Transduction second edition details the sources, key observations, and experiments that set the scene for recent and current scientific endeavour. Beginning with a historical overview, this book discusses how the concept of chemical messengers arose in the early twentieth century and shaped our current understanding of the action of hormones, cytokines, neurotransmitters, and growth factors." "The book further examines more complex signalling cascades, emanating from classic receptors, as well as adhesion molecules, involved in processes such as vision, smell, inflammation, innate and adaptive immunity, glucose homeostasis, cell-fated decisions, cell differentiation, and cell transformation. This revision concludes with a discourse on the targeting of signal-transduction cascades in the treatment of cancer and the structure of protein domains key to the assembly of signalling complexes"--Book jacket.
  • 2011From: Springer Protocols
    edited by Louis M. Luttrell, Stephen S.G. Ferguson.
  • 2016From: ClinicalKey
    IJsbrand M. Kramer.
    Prologue : signal transduction from an historical perspective -- An introduction to signal transduction -- Regulation of muscle contraction by adrenoceptors -- Cholinergic signaling and muscle contraction -- Sensory signal processing; visual transduction and olfaction -- Intracellular calcium -- Bringing the signal into the nucleus : regulation of gene expression -- Nuclear receptors -- Protein kinase c in oncogenic transformation and cell polarity -- Regulation of cell proliferation by receptor tyrosine protein kinases -- Signal transduction to and from adhesion molecules -- WNT signaling and the regulation of cell adhesion and differentiation -- Activation of the innate immune system : the toll-like receptor-4 and signaling through ubiquitinylation -- Chemokines and traffic of white blood cells -- Activating the adaptive immune system : role of non-receptor tyrosine kinases -- Signaling through the insulin receptor : phosphoinositide 3-kinases and AKT -- TGF[beta] and signaling through receptor serine/threonine protein kinases -- Protein phosphatases -- Cell fate determination by notch.
  • 2008From: CRCnetBASE
    edited by Gregory W. Konat.
    Assessing the response of cells to TLR stimulation / Kiyoshi Takeda, Masahiro Yamamoto, and Kenya Honda -- TLR ligands in experimental settings their purity and specificity / Min-Fu Tsan -- Analysis of TLR expression, regulation, and signaling / Hui Xiao, Xiaoxia Li, and Derek W. Abbott -- Intracellular trafficking of toll-like receptors / Harald Husebye ... [et al.] -- The role of small RhoGTPases in TLR signaling / Monica Ruse and Ulla G. Knaus -- Use of engineered [beta]-lactamase fragment complementation to detect the associations of toll-like receptors and signaling adaptors / Hyun-Ku Lee and Peter S. Tobias -- Use of toll-like receptor chimeras to dissect mechanisms of receptor localization and signaling / Tadashi Nishiya and Anthony L. DeFranco -- Engagement of toll-like receptors modulates chemokine receptor signaling / Chong-Shan Shi and John H. Kehrl -- Role of toll-like receptor signaling in central nervous system infections / Tammy Kielian -- The influence of injury on toll-like receptor responses / Thomas J. Murphy ... [et al.].
  • 2011From: Springer
    by José Marín-García ; with contributions by Alexander Ahkmenov.
    Tools to Study Signaling -- Cell-Cycle Signaling, Epigenetics, and Nuclear Function -- Signaling in the Endothelium -- Rapid Signaling Pathways -- Growth Factors Signaling -- Ion Signaling and Electrophysiological Function -- Lipid Signaling Pathways in the Heart -- Heart Mitochondria: A Receiver and Integrator of Signals -- Signaling Pathways in Cardiovascular Development -- Signaling in Congenital Heart Disease -- Signaling in the Aging Heart -- Signaling in Endomyocarditis -- Signaling in Hypertension -- Gene Expression and Signaling Pathways in Myocardial Ischemia -- Signaling in Hypertrophy and Heart Failure -- Signaling in Diabetes and Metabolic Syndrome -- Dysrhythmias/Channelopathies and Signaling Pathways -- Signaling in Atherosclerosis -- Stem Cells Signaling Pathways in the Heart -- Cardioprotection and Signaling Pathways -- Targeting Signaling Pathways -- Signaling and the Frontiers Ahead.
  • Swathi Arur, editor.
  • Vittorio de Franciscis, Laura Cerchia, Bertrand Tavitian, editors.
    PrintStatus: Not Checked OutLane Catalog Record
    Targeting receptor tyrosine kinase mutations in cancer / Mark Pearson and Doriano Fabbro -- The RET proto-oncogene: a valuable target for thyroid cancer therapy / Brigitte M. Pützer -- Inhibitors of HER/erbB receptors: biological bases and clinical applications / Vincenzo Damiano ... [et al.] -- Phosphatases as promising targets for cancer therapy / Marc Creus and Heinz Zoller -- Targeting the mTOR pathway for cancer therapy / Sabita Sankar -- Targeting MAP kinase signaling pathways for the treatment of cancer / Maria Julia Marinissen and Mario Chiariello -- Cell death-based therapy / Gerolama Condorelli ... [et al.] -- Signaling molecules and therapeutic targets in gliomas / Hrvoje Miletic, Parisa Monfared and Andreas H. Jacobs -- Identifying and targeting genes involved in childhood leukemia / Jenny Yeung and Hugh J.M. Brady -- Receptor binding peptides for receptor mediated endoradiotherapy in oncology / Walter Mier, Uwe Haberkorn and Michael Eisenhut.
  • 2012From: Springer
    Alessandro Fatatis, editor.
    This work presents the most advanced discoveries from translational research laboratories directly involved in identifying molecules and signalling pathways that play an instrumental role in metastasis. In contrast to other works, conventionally focused on a single type of tumour, the various chapters in this book provide a broad perspective of the similarities and discrepancies among the dissemination of several solid malignancies. Through recurrent and overlapping references to molecular mechanisms and mediators, the readers will gain knowledge of the common ground in metastasis from a single source. Finally, an introductory chapter provides a clinical perspective of the problems presented by metastatic tumours for diagnosis and treatment. The work presented here is directed to researchers in tumour biology with a developing interest in metastatic dissemination as well as medical and graduate students seeking to expand and integrate the notions acquired in basic cancer biology and oncology courses.
  • 2012From: Springer
    David A. Frank, editor.
    This text describes research suggesting that abnormal activation of signaling pathways is a critical event in cancer pathogenesis, and describes the emerging ability to design small molecules, protein therapeutics, and other forms of targeted cancer therapies.
  • 2010From: Springer
    Jean-François Dufour, Pierre-Alain Clavien (eds.).
  • 2011From: Springer
    Adam B. Glick, Carter Van Waes, editors.
  • 2008From: Springer
    edited by Leoni Villano Bonamin.
  • 2011From: Springer
    Vitomir Šunjić, Michael J. Parnham.
  • 2015From: ProQuest Ebook Central
    editors, Henry M. Adams, Jane Meschan Foy.
    Abdominal distention -- Abdominal pain -- Alopecia and hair shaft anomalies -- Amenorrhea -- Anemia and pallor -- Anxiety -- Ataxia -- Back pain -- Cardiac arrhythmias -- Chest pain -- Constipation -- Cough -- Cyanosis -- Depression -- Diarrhea and steatorrhea -- Disruptive behavior and aggression -- Dizziness and vertigo -- Dysmenorrhea -- Dysphagia -- Dyspnea -- Dysuria -- Edema -- Epistaxis -- Extremity pain -- Facial dysmorphism -- Failure to thrive: pediatric undernutrition -- Family dysfunction -- Fatigue and weakness -- Fever -- Fever of unknown origin -- Foot and leg problems -- Gastrointestinal hemorrhage -- Gender expression and identity issues -- Headache -- Hearing loss -- Heart murmurs -- Hematuria -- Hemoptysis -- Hepatomegaly -- High blood pressure -- Hirsutism, hypertrichosis, and precocious sexual hair development -- Hoarseness -- Hyperhidrosis -- Hypotonia -- Inattention and impulsivity -- Irritabilitya and fussiness -- Jaundice -- Joint pain -- Learning difficulty -- Limp -- Loss of appetite -- Lymphadenopathy -- Macrocephaly -- Medically unexplained symptoms -- Microcephaly -- Nonconvulsive periodic disorders -- Odor (Unusual urine and body) -- Petechiae and purpura -- Polyuria -- Proteinuria -- Pruritus -- Puberty: normal and abnormal -- Rash -- Recurrent infections -- Red eye/pink eye -- School absenteeism and school refusal -- Scrotal swelling and pain -- Self-harm -- Self-stimulating behaviors -- Short stature -- Sleep disturbances (Nonspecific) -- Speech and language concerns -- Splenomegaly -- Stridor -- Substance use: initial approach in primary care -- Symptoms of emotional disturbance in young children -- Syncope -- Temper -- Tics -- Torticollis -- Vaginal bleeding -- Vaginal discharge -- Vomiting -- Weight loss -- Wheezing
  • 2012From: ClinicalKey
    Paul M. Paulman [and others].
    1. Abdominal Pain -- 2. Abnormal Vaginal Bleeding -- 3. Amenorrhea -- 4. Anemia -- 5. Anxiety -- 6. Arthralgia -- 7. Back Pain -- 8. Behavior Problems in Children -- 9. Bleeding and Bruising -- 10. Blood in Stool -- 11. Breast Masses and Nipple Discharge -- 12. Chest Pain -- 13. Child Abuse -- 14. Confusion -- 15. Congestion -- 16. Cough -- 17. Depression -- 18. Diarrhea -- 19. Dizziness -- 20. Earache -- 21. Family Discord -- 22. Fatigue -- 23. Fever -- 24. Headache -- 25. Health Maintenance -- 26. Heartburn -- 27. Hypertension -- 28. Jaundice -- 29. Lower Extremity Pain and Swelling -- 30. Lymphadenopathy -- 31. Menopause --- 32. Neck Pain -- 33. Pelvic or Genital Pain -- 34. Polyuria -- 35. Rashes -- 36. Seizures -- 37. Sexual Dysfunction -- 38. Shortness of Breath -- 39. Sleep Disorders -- 40. Sore Throat -- 41. Substance Abuse -- 42. Urinary Problems -- 43. Vaginal Discharge -- 44. Generalized Weakness -- 45. Weight Change
  • 2008From: Springer
    Werner A. Kaiser.
  • 2010From: ClinicalKey
    Jack J. Kanski.
    Eyelids -- Orbit -- Conjunctiva -- Episclera and sclera -- Cornea -- Anterior chamber -- Intraocular pressure and angle -- Iris -- Pupils -- Lens -- Vitreus -- Optic nerve head -- Fundus -- Ocular motility -- Systemic signs.
  • 2008From: Springer
    Michel Vinogradoff.
  • 2016From: Oxford Medicine Online
    Rebecca Dresser.
    The research ethics system was created without the help of people who know what it is like to be a research subject. This is a serious omission. Experts have overlooked ethical issues that matter to subjects. Silent Partners moves subjects to the forefront, giving them a voice in research ethics.
  • R.R. Sayers [and others].
  • 2015From: Cambridge
    edited by Mark R. Wick, Virginia A. LiVolsi, John D. Pfeifer, Edward B. Stelow, Paul E. Wakely, Jr.
    General philosophy and principles of surgical pathology and cytopathology, including quality and legal issues / Mark R. Wick -- General and special techniques in surgical pathology; cytopathology / Mark R. Wick, Robin D. LeGallo, Edward B. Stelow, and John D. Pfeifer -- Pathology of selected infectious diseases / Mark R. Wick and Margie A. Scott -- Immunological diseases and transplantation pathology / Edward C. Klatt -- The pathology of iatrogenic lesions / Mark R. Wick and Robert E. Fechner -- Differential diagnosis of metastatic tumors / Tarik M. Elsheikh and Jan F. Silverman -- Surgical pathology of non-neoplastic skin disease / Kenneth B. Calder, Wang Cheung, James N. Lampros, and Bruce R. Smoller -- Cutaneous tumors and tumor-like conditions / Mark R. Wick, David J. Glembocki, Mark W. Teague, and James W. Patterson -- Soft tissue tumors / Elizabeth Montgomery -- The breast / John D. Pfeifer, James L. Connolly, Timothy W. Jacobs, and Mark R. Wick -- Lymph nodes and spleen / Karen L. Chang Daniel A. Arber, and Lawrence M. Weiss -- Bone marrow / Nora C.J. Sun, Jun Wang, Sheila X. Zhao and Eric F. Glassy.
  • 2015From: AccessEmergency Medicine
    editor, Scott C. Sherman ; contributing authors, Ghazala Q. Sharieff [and 31 others] ; with illustrations by Susan Gilbert and Catherine Delphia.
    Companion videos presents step-by-step procedures for splinting, arthrocentesis, injections, and reduction of fractures and dislocations. The book's Fracture Index illustrates every posssible fracturee of each bone.
  • 2015From: Springer
    Filippo Castoldi, Davide Blonna, Marco Assom, editors.
    The treatment of humeral fractures is a complex issue and the source of considerable controversy. In the case of fractures of the proximal humerus, early range of motion is the main aim of treatment. If a fracture modifies the anatomy or function of the glenohumeral and scapulothoracic joints, the surgeon must adhere meticulously to treatment principles in order to ensure a satisfactory outcome. Humeral shaft fractures are frequent, accounting for 1% to 3% of all fractures in adults; while excellent functional results have been reported with nonoperative management, open reduction and internal fixation is preferred in specific clinical settings. In contrast, intra-articular fractures of the distal humerus are frequently complex and full functional recovery is difficult to achieve. This volume clearly explains the concepts that are central to an understanding of humeral fractures from the proximal to the distal tip. Indications for different forms of treatment, including nonsurgical, are presented in detail, and all of the commonly used fixation techniques are described with the help of high-quality illustrations. Further important aspects such as complications, rehabilitation, and treatment of sequelae are also fully considered. This book will be an invaluable and comprehensive aid for all surgeons who treat humeral fractures.
  • 2008From: Springer
    Melvin A. Shiffman, Sid J. Mirrafati, Samuel M. Lam, editors ; Chelso G. Cueteaux, associate editor.
  • 2015From: OSO
    Gerd Gigerenzer.
    Statistical illiteracy can have an enormously negative impact on decision making. This book brings together applied and theoretical research on risks and decision making across the fields of medicine, psychology, and economics. Collectively, the chapters demonstrate why the frame in which statistics are communicated is essential for broader understanding and sound decision making, and that understanding risks and uncertainty has wide-reaching implications for daily life.
  • 2015From: ClinicalKey
    Femi Oyebode, MBBS, MD, PHD, FRCPSYCH, Professor of Psychiatry & Consultant Psychiatrist, University of Birmingham, National Centre for Mental Health, Birmingham, UK.
    Fundamental concepts of descriptive psychopathology -- Eliciting the symptoms of mental illness -- Consciousness and disturbed consciousness -- Attention, concentration, orientation, and sleep -- Disturbance of memory -- Disorder of time -- Pathology of perception -- Delusions and other erroneous ideas -- Disorder of the thinking process -- Disorder of speech and language -- Insight -- The disordered self -- Depersonalization -- Disorder of the awareness of the body -- The psychopathology of pain -- Affect and emotional disorders -- Anxiety, panic, irritability, phobia, and obsession -- Disorders of volition and execution -- The expression of disordered personality -- Psychopathology and diagnosis.
  • 2016From: Springer
    Harry Owen.
    1 Introduction -- Part I -- 2 Early Examples of Simulation in Training and Healthcare -- 3 Simulation in Medical Science -- Part II -- 4 Simulation in Obstetrics and Midwifery -- Part III -- 5 Simulators and Teaching Aids Used in Teaching Medicine -- 6 Simulation in Surgery -- 7 Simulation in Oto-, Rhino-, and Laryngology -- 8 Simulation in the Treatment of Eye Disorders -- 9 Simulation in Nursing -- 10 Simulation and Teaching in Resuscitation and Trauma Management -- 11 Simulation in Dentistry and Dental Hygiene -- Index.
  • 2012From: Springer
    Hitendra R.H. Patel, Jean V. Joseph, editors.
    Lessons Learned from the Aviation Industry: Surgical Checklists / Stig Müller and Hitendra R. H. Patel -- Human Factors, Nontechnical Skills, and Surgical Training / Stig Müller, Waleed Al-Singary and Hitendra R. H. Patel -- Current State of Laparoscopic and Robotic Surgery / Jens J. Rassweiler, Marcel Hruza, Thomas Frede and Salvatore Micali -- Simulation and Training in Minimally Invasive Surgery / Sonal Arora, Shabnam Undre and Roger Kneebone -- Value of Virtual Reality in Medical Education / Amina A. Bouhelal, Hitendra R. H. Patel and Bijendra Patel -- The MIMIC Virtual Reality Trainer: Stepping into Three-Dimensional, Binocular, Robotic Simulation / Steven M. Lucas and Chandru P. Sundaram -- Laparoscopic Cholecystectomy Skills Acquisition and Procedural Proficiency in Novices Using Virtual Reality / Amina A. Bouhelal, Hitendra R. H. Patel and Bijendra Patel -- Lesson Learnt from the Military Surgeons Using Simulation in Trauma Surgery / Simon S. Fleming and John-Joe Reilly -- Clinical and Educational Benefits of Surgical Telementoring / Knut Mague Augestad, Taridzo Chomutare, Johan G. Bellika, Andrius Budrionis and Rolv-Ole Lindsetmo, et al. -- Portable Learning and Multimedia in Surgical Training / Narinderjit Singh Kullar, Stig Müller and Hitendra R. H. Patel.
  • 2015From: Cambridge
    edited by Lisa Jacobson, MD, University of Florida College of Medicine, Jacksonville, FL, USA, Yasuharu Okuda, MD, University of Central Florida College of Medicine and Veterans Health Administration, Jacksonville, FL, USA, Steven Godwin, MD, University of Florida College of Medicine, Jacksonville, FL, USA.
    Why SimWars -- What is SimWars -- SimWars: how to succeed -- SimWars debriefing: the art of the show -- SimWars judging: maximizing the educational value of a popular educational modality -- Troubleshooting technology -- Terminal extubation -- Industrial fire victim: burns and cyanide toxicity -- Pool diving accident -- Difficult airway -- house fire -- 'Is there a doctor on the plane?': Airplane anaphylaxis -- Hyperthermia on a cruise ship -- Hypertensive emergency -- Adrenal insufficiency -- 'Raving' altered mental status -- Two patients with altered mental status and cyanosis -- Severe asthma -- High-altitude pulmonary edema with high-altitude cerebral edema -- SCUBA -- air embolism -- LVAD -- Aortic dissection mimicking as STEMI -- Procedural sedation gone wrong in patient with upper GI hemorrhage -- Transfer gone wrong -- NG tube in the trachea -- Septic shock secondary to pneumonia -- AMS/hemorrhagic fever -- Tetany in a home-body piercer -- Pediatric myocarditis -- Neonatal HSV meningo/encephalitis -- Traumatic brain injury -- Status epilepticus -- Intracranial hemorrhage -- Stroke/health information technology case -- Football injury -- cervical spine fracture with neurogenic shock -- Floppy newborn resuscitation -- Post mortem C-section with seizing neonate at delivery -- Shoulder dystocia with postpartum hemorrhage -- Pediatric status epilepticus -- Neonatal cardiac arrest -- Anaphylaxis/boarding patient -- Zofran and long QTc syndrome -- Pediatric death debrief -- Infant abuse and the angry team member -- Intoxicated father with child neglect -- Body packer -- Multiple altered patients with carbon monoxide (CO) poisoning -- HazMat/decontamination response with complicated communication -- Migraines and beta blocker overdose -- Blast injury -- Multi-victim trauma case -- Traumatic head bleed/trephination -- Trapped in the elevator -- I'm never riding rollercoasters again -- Appendix A: Thinking about the cases with ACGME milestones in mind -- Appendix B. Moulage in minutes -- Appendix C. Case images.
  • 2014From: Springer
    [edited by] Jozef Rovensky, Manfred Herold, Martina Vasakova.
    Sine syndromes (SSs) represent atypical forms of inflammatory rheumatic diseases, the courses of which are often severe. While the diagnosis of rheumatic diseases can be determined according to an established set of diagnostic criteria based on clinical characteristics and laboratory parameters, Sine Syndromes do not fulfill the standard criteria used to assist in the classification of patients with rheumatological disorders. This concise book gives an overview of atypical courses in common inflammatory rheumatic diseases such as Wegener's granulomatosis, systemic sclerosis, Sjögren's syndrome, or systemic lupus erythematosus. Each chapter reviews similar cases reported in the literature and presents current data on treatment options. Drawing on their vast clinical experience, the editors provide a series of detailed case reports in order to illustrate the different types of disease. The book is intended to facilitate early diagnosis and effective therapy in patients where a schematic approach may not prove sufficient. Sine Syndromes in Rheumatology will serve as a useful and easily accessible reference for specialists in rheumatology as well as for practitioners in the fields of internal medicine, pediatrics, and orthopedics.
  • 2014From: Springer
    Giusto Pignata, Francesco Corcione, Umberto Bracale, editors.
    Single-access laparoscopic surgery (SALS), performed using a single transumbilical access, has recently proved to bring advantages over other forms of laparoscopic surgery due to the reduction in the number of incisions and the consequent decrease in morbidity, less blood loss and postoperative pain. Furthermore, cosmesis may be improved because incision within the umbilicus renders surgery virtually scarless. Nevertheless, as with all new surgical concepts, questions may be raised regarding safety, usefulness, and appropriateness. This book analyzes the use of SALS for different indications and abdominal surgical procedures based on a careful literature review of the experience of the most important surgical teams employing this approach and also the authors' personal observations. The coverage is broad, encompassing, for example, the role of SALS in appendectomy, repair of abdominal wall defects, cholecystectomy, gastric surgery, nephrectomy, splenectomy, hemicolectomy, and pancreatic, liver, and gynecological surgery. Resident surgeons specializing in laparoscopy, researchers, and related healthcare professionals will find Single-Access Laparoscopic Surgery to be an invaluable source of information in an area which deserves to receive detailed attention.
  • 2016From: Cambridge
    Keith Davies, Christopher Gough, Emma King, Benjamin Plumb, Benjamin Walton.
  • 2012From: Springer Protocols
    edited by Sara Lindström, Helene Andersson-Svahn.
    Introduction : why analyze single cells / Dino Di Carlo, Henry Tat Kwong Tse, and Daniel R. Gossett -- Flow cytometry and microscopy as means of studying single cells : a short introductional overview / Sara Lindstrom -- Identification of enzyme-converted peptide products from single cells using capillary electrophoresis and liquid chromatography-mass spectrometry / Robert B. Brown [and others] -- Laser capture microdissection for gene expression analysis of specific cell populations in single blastocysts / Ward De Spiegelaere, Muriel Filliers, and Ann Van Soom -- Single-cell culture in microwells / Sara Lindstrom and Helene Andersson-Svahn -- Isodielectric separation and analysis of cells / Michael D. Vahey and Joel Voldman -- Single cell electroporation using microfluidic devices / Severine Le Gac and Albert van den Berg -- Perfusion culture of mammalian cells in a microfluidic channel with a built-in pillar array / Chi Zhang -- Padlock probes and rolling circle amplification for detection of repeats and single-copy genes in the single-cell comet assay / Sara Henriksson and Mats Nilsson -- Droplet microfluidics for single-cell analysis / Eric Brouzes -- Screening of antigen-specific antibody-secreting cells / Hiroyuki Kishi [and others] -- Analysis of single eukaryotic cells using raman tweezers / Elsa Correia Faria and Peter Gardner -- Single-cell microinjection technologies / Yan Zhang -- Ultrasonic manipulation of single cells / Martin Wiklund and Bjorn Onfelt -- Expanding the horizons for single-cell applications on lab-on-a-chip devices / Soo Hyeon Kim, Dominique Fourmy, and Teruo Fujii -- Analytical technologies for integrated single-cell analysis of human immune responses / Ayca Yalcın, Yvonne J. Yamanaka, and J. Christopher Love.
  • William Edward O'Gorman.
    Cytokines are essential in the orchestration of effective innate and adaptive immune responses. Immunologists have focused extensively on identifying cytokines, and the cells that produce cytokines, yet there is still little understanding of the complex dynamics that govern cytokine responses in vivo during infection. Chapter 1 provides a general introduction to the cytokine signaling induced by innate and adaptive immune responses. Emphasis is placed on the activation of the signal transducers and activator of transcription (STAT) family of transcription factors by numerous cytokines because monitoring of STAT activation is a sensitive biochemical marker of the cytokine response. Chapter 2 describes the in vivo innate inflammatory response to poxvirus infection. Chapters 3 deals with adaptive immunity and specifically the cytokine responses elicited in vivo by antigen specific T cell activation. Chapter 2 presents experiments demonstrating that early after in vivo exposure to various microbe-associated molecular patterns, STAT1 and STAT3 activation is potently induced in splenic dendritic cells and T cells. Mice with targeted gene deletions were used to identify toll-like receptors (TLRs), interferons, and interleukin-6 (IL-6) as necessary for early STAT activation. These experiments with reductionist microbial ligands demonstrated the feasibility of analyzing the cytokine response to infection with an intact pathogen in vivo. Chapter 2 goes on to describe the innate cytokine response to viral infection in experiments comparing the immune response to two closely related poxviruses: vaccinia and ectromelia (mousepox). Early and robust STAT1 and STAT3 activation was found to strongly correlate with survival of poxvirus infection. In addition, different modes of innate immune recognition distinguished vaccinia from ectromelia infection with toll-like receptor 2 (TLR2) activation being unique to immune recognition of vaccinia and not of ectromelia. These results suggest that different modes of early innate immune recognition could play an essential role in the containment of poxvirus infections and underlie the strict host species specificity of poxviruses. Chapter 3 deals with the paracrine cytokine responses elicited by antigen specific T cell activation in vivo. Using a T cell receptor (TCR) transgenic model we found profound and sustained activation of STAT5 in the Foxp3+ T regulatory cells (T regs) of mice immunized with a model peptide antigen after the adoptive transfer of antigen specific T cells. STAT5 activation in T regulatory cells was found to be interleukin-2 (IL-2) dependent and IL-2 signals elicited T regulatory cell proliferation and enhanced suppressive functions. Infection with vaccinia virus yielded a similar pattern of STAT5 activation in T regulatory cells, and STAT5 signaling was found to be even more potent under conditions of preexisting immune memory. These experiments revealed that antigen specific T-cell activation is intrinsically linked via paracrine IL-2 production to the activation of the polyclonal T reg repertoire, a response mechanism that could prevent autoimmunity. Chapter 3 also describes the regulation of autocrine IL-2 signaling during antigen specific T cell activation. Surprisingly, following TCR stimulation in vivo DO11 T cells did not display potent STAT5 activation even though these cells produced IL-2 and expressed the high affinity IL-2 coreceptor CD25. Only upon secondary TCR stimulation was robust autocrine IL-2 dependent STAT5 activation observed. Overall, these experiments demonstrate the nuances of IL-2/STAT5 signaling across numerous innate and adaptive cells populations revealing that in vivo T regulatory cells are extremely sensitive to antigen specific T cell activation. Targeting IL-2 signals specifically to antigen specific T cells while blocking IL-2 activation of T regs could enhance the efficacy of vaccination.
  • Erin Forbes Simonds.
    The human hematopoietic system is a complex mixture of morphologically and functionally distinct cell types. Using high-dimensional single-cell cytometry, functional behaviors in a wide number of cell types can be monitored simultaneously ("deep profiling"), enabling new insights into the structure and relationships of the overall system. Presented in this dissertation are several incremental technical and informatic steps that contributed to this holistic approach to single-cell biology. Using 30-parameter mass cytometry, deep profiling was used to recover the developmental continuum of healthy bone marrow and create a detailed map of the atypical functionally related cell types in a case of oligoclonal pediatric acute myeloid leukemia. These examples demonstrate the utility of a single-cell deep profiling paradigm in attaining an informative snapshot of healthy and malignant human hematopoiesis.
  • 2007From: Springer Protocols
    edited by Alan Thornhill.
    Noninvasive metabolic assessment of single cells / David K. Gardner -- Laser capture microdissection for analysis of single cells / Nobuki Nakamura ... [et al.] -- Fluorescence in situ hybridization (FISH) on single cells (sex determination and chromosome rearrangements) / Paul N. Scriven and Caroline Mackie Ogilvie -- Single cell PCR for PGD : methods, strategies, and limitations / Karen Sermon and Martine De Rycke -- Real-time quantitative PCR measurement of male fetal DNA in maternal plasma / Bernhard Zimmermann ... [et al.] -- Cell-free fetal DNA plasma extraction and real-time PCR quantification / Jill L. Maron, Kirby L. Johnson, and Diana W. Bianchi -- LATE-PCR and allied technologies : real-time detection strategies for rapid, reliable diagnosis from single cells / Kenneth E. Pierce and Lawrence J. Wangh -- Efficient isothermal amplification of the entire genome from single cells / Karen V. Schowalter, Jolene R. Fredrickson, and Alan R Thornhill -- Comparative genomic hybridization on single cells / Lucille Voullaire and Leeanda Wilton -- Generation of amplified RNAs and cDNA libraries from single mammalian cells / James Adjaye -- Real-time PCR to measure gene expression in single cells / Dagan Wells -- Gender determination and detection of aneuploidy in single cells using DNA array-based comparative genomic hybridization (array CGH) / Dong Gui Hui, Xin Yuan Guan, and Nicole Hussey -- Microarray technology for mutation analysis of low template DNA samples / Chelsea Salvado and David Cram.
  • Sarah Joann Aerni.
    Complex organisms contain many individual cells that express unique sets of genes. Unraveling the full complexity of organisms requires an understanding of the unique gene expression signatures of individual cells. Obtaining these cellular signatures enables a deeper understanding of the underlying biological processes, including development and aging. Model organisms, such as C. elegans, are ideal platforms for single-cell studies, offering true single-cell resolution. In the nematode, C. elegans, each of its 959 somatic cells are uniquely identifiable in every individual. Through high-resolution 3D imaging of in-situ fluorescent reporters, expression levels can be observed in all 959 cells. The key to making this powerful system a viable source of discovery through large-scale, high-resolution gene expression analysis requires automation of the annotation process. This dissertation describes computational approaches to identifying single-cells to obtain high-resolution gene expression levels in adult C. elegans. These approaches include an image processing pipeline enabling both manual and automatic annotation of images. For the latter, I describe a set of automatic annotation methods developed for single-cell identification in 3D confocal images of adult C. elegans utilizing machine learning approaches. These approaches automatically assign a set of labels to cells based on (1) cell-lineage, (2) tissue type or (3) the anatomical region occupied within the worm. Finally, this dissertation describes the types of biological insights researchers can gain from such high-resolution data. In particular, it develops a novel gene expression analysis method that combines the known cell lineage and expression levels of 96 genes in 363 single-cells in the first larval stage of C. elegans. Together, these methods provide C. elegans researchers with a powerful toolkit for performing single-cell gene expression analysis of worms. This work enables studies in the field of development and, for the first time, aging at the single-cell resolution using automated annotation approaches in the adult worm.
  • 2015From: Springer Protocols
    edited by Anup K. Singh and Aarthi Chandrasekaran.
    Single-cell western blotting -- A microfluidic device for immunoassay-based protein analysis of single E. coli bacteria -- Enzyme-linked immunospot (ELISpot) for single-cell analysis -- Photocleavable DNA barcoding antibodies for multiplexed protein analysis in single cells -- Genome-wide analysis of protein and mRNA copy numbers in single escherichia coli cells with single-molecule sensitivity -- Microfluidic flow cytometry for single-cell protein analysis -- Microfluidic image cytometry for single-cell phenotyping of human pluripotent stem cells -- Characterizing phenotypes and signaling networks of single human cells by mass cytometry -- Multiplexed peptide-MHC tetramer staining with mass cytometry -- Imaging and mapping of tissue constituents at the single-call level using MALDI MSI and quantitative laser scanning cytometry -- SPLIFF: A single-cell method to map protein-protein interactions in time and space -- Microfluidic proximity ligation assay for profiling signaling networks with single-cell resolution -- Dynamics and interactions of individual proteins in the membrane of single, living cells -- Microfluidics-enabled enzyme activity measurement in single cells -- Microfluidic chemical cytometry for enzyme assays of single cells -- Quantitative detection of nucleocytoplasmic transport of native proteins in single cells.
  • 2015From: Springer
    Xiangdong Wang, editor ; honor editors, Xiaoming Chen, Zhihong Sun, Jinglin Xia.
    The volume focuses on the genomics, proteomics, metabolomics, and bioinformatics of a single cell, especially lymphocytes and on understanding the molecular mechanisms of systems immunology. Based on the author?s personal experience, it provides revealing insights into the potential applications, significance, workflow, comparison, future perspectives and challenges of single-cell sequencing for identifying and developing disease-specific biomarkers in order to understand the biological function, activation and dysfunction of single cells and lymphocytes and to explore their functional roles and responses to therapies. It also provides detailed information on individual subgroups of lymphocytes, including cell characters, function, surface markers, receptor function, intracellular signals and pathways, production of inflammatory mediators, nuclear receptors and factors, omics, sequencing, disease-specific biomarkers, bioinformatics, networks and dynamic networks, their role in disease and future prospects. Dr. Xiangdong Wang is a Professor of Medicine, Director of Shanghai Institute of Clinical Bioinformatics, Director of Fudan University Center for Clinical Bioinformatics, Director of the Biomedical Research Center of Zhongshan Hospital, Deputy Director of Shanghai Respiratory Research Institute, Shanghai, China.
  • 2012From: Springer Protocols
    edited by Dirk Saerens and Serge Muyldermans.
    From whole monoclonal antibodies to single domain antibodies : think small / Jean-Luc Teillaud -- Introduction to heavy chain antibodies and derived nanobodies / Cecile Vincke and Serge Muyldermans -- Overview and discovery of IgNARs and generation of VNARs / Stewart D. Nuttall -- Creation of the large and highly functional synthetic repertoire of human VH and Vk domain antibodies / Olga Ignatovich [and others] -- Preparation of a naive library of camelid single domain antibodies / Aurelien Olichon and Ario de Marco -- Selection by phage display of single domain antibodies specific to antigens in their native conformation / Peter Verheesen and Toon Laeremans -- Semiautomated panning of naive camelidae libraries and selection of single-domain antibodies against peptide antigens / Jyothi Kumaran, C. Roger MacKenzie, and Mehdi Arbabi-Ghahroudi -- Pichia surface display : a tool for screening single domain antibodies / Kristof De Schutter and Nico Callewaert -- Bacterial two hybrid : a versatile one-step intracellular selection method / Mireille Pellis, Serge Muyldermans, and Cecile Vincke -- Intracellular antibody capture (IAC) methods for single domain antibodies / Tomoyuki Tanaka and Terence H. Rabbitts -- Selection of functional single domain antibody fragments for interfering with protein-protein interactions inside cells : a 'one plasmid' mammalian two-hybrid system / Tomoyuki Tanaka and Terence H. Rabbitts -- Cell-free selection of domain antibodies by in vitro compartmentalization / Armin Sepp and Andrew Griffiths -- Selection of VHHs under application conditions / Edward Dolk, Theo Verrips, and Hans de Haard -- Isolation and characterization of Clostridium difficile toxin-specific single-domain antibodies / Greg Hussack [and others] -- Selection of VHH antibody fragments that recognize different Ab depositions using complex immune libraries / Rinse Klooster, Kim S. Rutgers, and Silvere M. van der Maarel -- Expression of single-domain antibodies in bacterial systems / Toya Nath Baral and Mehdi Arbabi-Ghahroudi -- Expression of VHHs in Saccharomyces cerevisiae / Andrea Gorlani, Hans de Haard, and Theo Verrips -- Stable expression of chimeric heavy chain antibodies in CHO cells / Vishal Agrawal [and others] -- Production of Camel-Like Antibodies in Plants / Sylvie De Buck [and others] -- Selecting and purifying autonomous human variable heavy (VH) domains / Raffi Tonikian and Sachdev S. Sidhu -- Solubility and stability engineering of human VH domains / Dae Young Kim, Wen Ding, and Jamshid Tanha -- Improvement of proteolytic stability through in silico engineering / Lucy Rutten, Hans de Haard, and Theo Verrips -- Selection of human VH single domains with improved biophysical properties by phage display / Kip Dudgeon [and others] -- Improvement of single domain antibody stability by disulfide bond introduction / Yoshihisa Hagihara and Dirk Saerens -- Characterization of single-domain antibodies with an engineered disulfide bond / Greg Hussack, C. Roger MacKenzie, and Jamshid Tanha -- Affinity maturation of single-domain antibodies by yeast surface display / Akiko Koide and Shohei Koide -- Multivalent display of single-domain antibodies / Jianbing Zhang and C. Roger MacKenzie -- Methods for determining the PK parameters of AlbudAbs[TM] and of long serum half-life drugs made using the AlbudAb[TM] technology / Daniel Rycroft and Lucy J. Holt -- Fluorescent protein specific nanotraps to study protein-protein interactions and histone-tail peptide binding / Garwin Pichler, Heinrich Leonhardt, and Ulrich Rothbauer -- Site-specific labeling of his-tagged nanobodies with 99mTc : a practical guide / Catarina Xavier [and others] -- Nanobody-based chromatin immunoprecipitation / Trong Nguyen Duc [and others] -- User-friendly expression plasmids enable the fusion of VHHs to application-specific tags / Ario de Marco -- Application of single-domain antibodies in tumor histochemistry / Kien T. Maik and C. Roger MacKenzie -- Nanobodies as structural probes of protein misfolding and fibril formation / Erwin De Genst and Christopher M. Dobson -- Molecular imaging using nanobodies : a case study / Nick Devoogdt [and others] -- Case study on live cell apoptosis-assay using lamin-chromobody cell-lines for high-content analysis / Kourosh Zolghadr [and others].
  • 2014From: Springer
    Wai Lun Law, Conor P. Delaney, editors.
    Single Incision Laparoscopic and Transanal Colorectal Surgery provide a comprehensive and state-of-the art review of single incision laparoscopic and transanal colorectal surgery. The text concentrates on surgical techniques and tricks in single incision laparoscopic and transanal surgery with detailed descriptions of the techniques, as well as indications and limitations of the procedures. The newly available evidence on these procedures is emphasized and all procedures are richly illustrated with diagrams and photos. Written by experts in their fields, Single Incision Laparoscopic and Transanal Colorectal Surgery is a valuable resource for general surgeons, colon and rectal surgeons, laparoscopic GI surgeons, surgical residents and fellows in training interested in these two rapidly developing fields in colorectal surgery.
  • 2011From: Springer Protocols
    edited by Erwin J.G. Peterman and Gijs J.L. Wuite.
    Introduction to optical tweezers : background, system designs, and commercial solutions / Joost van Mameren, Gijs J.L. Wuite, and Iddo Heller -- Optical trapping and unfolding of RNA / Katherine H. White and Koen Visscher -- DNA unzipping and force measurements with a dual optical trap / Ismaı̈l Cissé, Pierre Mangeol, and Ulrich Bockelmann -- Probing the force generation and stepping behavior of cytoplasmic dynein / Arne Gennerich and Samara L. Reck-Peterson -- Brief introduction to single-molecule fluorescence methods / Siet M.J.L. van den Wildenberg, Bram Prevo, and Erwin J.G. Peterman -- Fluorescent labeling of proteins / Mauro Modesti -- Fluorescence imaging of single kinesin motors on immobilized microtubules / Till Korten [and others] -- Exploring protein superstructures and dynamics in live bacterial cells using single-molecule and superresolution imaging / Julie S. Biteen, Lucy Shapiro, and W.E. Moerner -- Fluorescence microscopy of nanochannel-confined DNA / Fredrik Persson, Fredrik Westerlund, and Jonas O. Tegenfeldt -- Fluorescence correlation spectroscopy / Patrick Ferrand, Jérôme Wenger, and Hervé Rigneault -- Introduction to atomic force microscopy / Pedro J. de Pablo -- Sample preparation for SFM imaging of DNA, proteins, and DNA-protein complexes / Dejan Ristic, Humberto Sanchez, and Claire Wyman -- Single-molecule protein unfolding and refolding using atomic force microscopy / Thomas Bornschlögl and Matthias Rief -- How to perform a nanoindentation experiment on a virus / Wouter H. Roos -- Magnetic tweezers for single-molecule manipulation / Yeonee Seol and Keir C. Neuman -- Probing DNA topology using tethered particle motion / David Dunlap [and others].
  • Hsiao-lu Lee.
    Since the first successful detection single molecules over two decades ago, single-molecule spectroscopy has developed into a burgeoning field with a wealth of experiments at room temperature and inside living cells. Probing asynchronous and heterogeneous populations in situ, one molecule at a time, is not only desirable, but critical for many biological questions. Further, super-resolution imaging based on sequential imaging of sparse subsets of single molecules, has seen explosive growth within the last five years. This dissertation describes both the application of live-cell single-molecule imaging as an answer to important biological questions, and development and validation of fluorescent probes for targeted super-resolution imaging.
  • 2009From: ScienceDirect
    [edited by] Alex E. Knight.
    The "single molecule" paradigm / Alex E. Knight -- Single molecule studies of myosins / Rachel E. Farrow ... [et al.] -- Single molecule experiments and the kinesin motor protein superfamily : walking hand in hand / Lukas C. Kapitein and Erwin J.G. Peterman -- Force-generating mechanisms of dynein revealed through single molecule studies / Kazuhiro Oiwa and Hiroaki Kojima -- The bacterial flagellar motor / Yoshiyuki Sowa and Richard M. Berry -- Single molecule studies of chromatin structure and dynamics / Sanford H. Leuba and Laurence R. Brewer -- Single molecule studies of nucleic acid enzymes / Samir M. Hamdan and Antoine M. van Oijen -- Single molecule studies of prokaryotic translation / Colin Echeverría Aitken ... [et al.] -- Single ion channels / David Colquhoun, Remigijus Lape, and Lucia Sivilotti -- Single molecule fluorescence in membrane biology / Lydia M. Harriss and Mark I. Wallace -- Single molecule microarray analysis / Jan Hesse ... [et al.].
  • Johan Oscar Lennart Andreasson.
    Kinesin family proteins are nanoscale motors involved in many essential biological processes, such as intracellular transport and cell division. The biological function of most kinesin motors is to use the energy from ATP hydrolysis to move cargo through a crowded cellular environment, quickly taking 8-nm steps along cytoskeletal microtubules. By maintaining its two motor domains (heads) out of phase, kinesin can complete hundreds of steps per encounter with the microtubule, and can do so against pN-scale loads. The physiological role of kinesin is directly related to its movement and in this dissertation I present several single-molecule studies where the force-dependent motion of individual kinesin motors was studied using optical trapping techniques. In humans, the kinesin superfamily includes over forty genes encoding different kinesin proteins, classified into 15 families, and motors from several families were studied in this work. Optical traps use lasers to detect the position of biological molecules, at nm-scale resolution, and to directly manipulate them by applying pN-scale forces. In this dissertation, I present two novel optical traps. The first uses highly linear electro-optic deflection of the laser light to create an instrument with fast feedback that is optimized for work with kinesin motors. The second instrument, an "Optical Torque Wrench", is a trap that can apply both forces and torques on birefringent particles. By controlling the light polarization in the sample plane, the rotation of nanofabricated quartz cylinders can be controlled in real time while the applied torque is measured directly. The functionalized particles can be used to twist DNA or other biological molecules. The kinesin motor domains are coordinated during stepping and the inter-head communication is believed to be conferred by the neck linker, a 14-amino acid structural element connecting the head to the common coiled-coil stalk. By extending this segment, we could examine its role in gating the mechanochemical cycle. A six-amino acid insert in the neck linker of a cysteine-light human kinesin construct led to unexpected ATP-dependent backstepping under load. These observations could be explained by a branched pathway where both ATP unbinding and hydrolysis were gated by the direction of the neck linker. Lengthening the neck linker also led to futile hydrolysis. Further experiments on the effects of neck linker length were done with a series of Drosophila Kinesin-1 mutants, with one to six extra residues in the neck linker. The rate of force-dependent rear head release and the internal strain developed during stepping was determined from force-dependent velocities and we also found that the mechanism of detachment from the microtubule depends on the direction of load. The heterotrimeric Kinesin-2 motors are unique in that they are the only kinesin family motors that consist of two different catalytic domains. Here, the mammalian Kinesin-2, KIF3A/B, was studied in detail by performing optical trapping experiments with both the wild-type dimer and with homodimers (KIF3A/A and KIF3B/B). A pathway that incorporates the individual catalytic cycles for KIF3A and KIF3B could explain all force- and ATP-dependent kinetics and surprisingly we found that the run lengths for KIF3A/B were significantly shorter than for Kinesin-1. Furthermore, motors with the weakly force-dependent KIF3A head "slipped" and exhibited short run lengths that were rescued under no load, indicating that KIF3A/B combines a Kinesin-1-like motor domain (KIF3B) with a unique and "weak" one (KIF3A). Finally, I present motility experiments where force-dependent kinetics were explored for several other kinesin family motors. KIF17 (Kinesin-2) and CENP-E (Kinesin-7) are robust, processive motors whereas KIF4A, a Kinesin-4 motor, is fast but unable to sustain significant loads. These results, together with those for Kinesin-1, KIF3A/B (Kinesin-2), and other motors, show that forces are needed fully reveal the motor characteristics and differences between various kinesin proteins. They also illustrate the remarkable diversity within the kinesin superfamily.
  • 2016From: ScienceDirect
    edited by Maria Spies and Yann R. Chemla.
    Chapter 1. Direct fluorescent imaging of translocation and unwinding by individual DNA helicases -- Chapter 2. Single-molecule imaging with one color fluorescence -- Chapter 3. Measuring membrane protein dimerization equilibrium in lipid bilayers by single-molecule fluorescence microsopy -- Chapter 4. Fluorescent labeling of proteins in whole cell extracts for single-molecule imaging -- Chapter 5. Quantifying the assembly of multicomponent molecular machines by single-molecule total internal reflection fluorescence microscopy -- Chapter 6. How to measure separations and angles between intramolecular fluorescent markers -- Chapter 7. Precisely and accurately inferring single-molecule rate constants -- Chapter 8. Quantification of functional dynamics of membrane proteins reconstituted in nanodiscs membranes by single turnover functional readout -- Chapter 9. Putting Humpty-Dumpty together: clustering the functional dynamics of single biomolecular machines such as the splicosome -- Chapter 10. Single-molecule FRET to measure conformational dynamics of DNA mismatch repair proteins -- Chapter 11. Single-molecule confocal FRET microscopy to dissect conformational changes in the catalytic cycle of DNA topoisomerases -- Chapter 12. Probing the conformational landscape of DNA polymerases using diffusion-based single-molecule FRET -- Chapter 13. Methods for investigating DNA accessibility with single nucleosomes -- Chapter 14. Single-molecule fluorescence studies of fast protein folding -- Chapter 15. Single-molecule multicolor FRET assay for studying structural dynamics of biomolecules -- Chapter 16. A multicolor single-molecule FRET approach to study protein dynamics and interactions simultaneously -- Chapter 17. Interferometric scattering microscopy for the study of molecular motors -- Chapter 18. Enzyme kinetics in femtoliter arrays -- Author index -- Subject index.
  • 2017From: ScienceDirect
    edited by Maria Spies and Yann R. Chemla.
  • 2011From: Springer Protocols
    edited by Gregory I. Mashanov, Christopher Batters.
    Single enzyme studies : a historical perspective / Alex E. Knight -- Functional surface attachment in a sandwich geometry of GFP-labeled motor proteins / Volker Bormuth [and others] -- Studying kinesin's enzymatic cycle using a single-motor confocal motility assay, employing Förster resonance energy transfer / Zdenek Lansky and Erwin J.G. Peterman -- Fluorescence imaging with one nanometer accuracy : in vitro and in vivo studies of molecular motors / Melinda Tonks Hoffman, Janet Sheung, and Paul R. Selvin -- Snapshots of kinesin motors on microtubule tracks / Franck J. Fourniol and Carolyn A. Moores -- Structural and dynamic characterization of biochemical processes by atomic force microscopy/ Frédéric Eghiaian and Iwan A.T. Schaap -- Using optical tweezers to study the fine details of myosin ATPase mechanochemical cycle / Christopher Batters and Claudia Veigel -- Quantum dot labeling strategies to characterize single-molecular motors / Shane R. Nelson, M. Yusuf Ali, and David M. Warshaw -- Imaging individual myosin molecules within living cells / Tatiana A. Nenasheva [and others] -- Single-molecule measurements using microneedles / Toshio Yanagida, Yoshiharu Ishii, and Akihiko Ishijima -- Fluorescent nucleoside triphosphates for single-molecule enzymology / Christopher P. Toseland and Martin R. Webb -- Probing the mechanics of the complete DNA transcription cycle in real-time using optical tweezers / Christoph G. Baumann and Stephen J. Cross -- Single-molecule approach to visualize the unwinding activity of DNA helicases / Natalia Fili [and others] -- Real-time single-molecule observation of green fluorescent protein synthesis by immobilized ribosomes / Ryo Iizuka, Takashi Funatsu, and Sotaro Uemura -- Single-molecule measurements of topoisomerase activity with magnetic tweezers / Yeonee Seol and Keir C. Neuman -- Assembly of recombinant nucleosomes on nanofabricated DNA curtains for single-molecule imaging / Ja Yil Lee and Eric C. Greene -- Simultaneous observation of chemomechanical coupling of a molecular motor / Takayuki Nishizaka, Yuh Hasimoto, and Tomoko Masaike -- Microsecond resolution of single-molecule rotation catalyzed by molecular motors / Tassilo Hornung [and others].
  • Whitney Clara Duim.
    Single-molecule, super-resolution fluorescence microscopy is a powerful technique for studying biological systems because it reveals details beyond the optical diffraction limit (on the 20-100 nm scale) such as structural and conformational heterogeneity. Further, single-molecule imaging measures distributions of behaviors directly through the interrogation of many individual molecules and reports on the nanoscale environment of molecules. Sub-diffraction imaging adds increased resolution to the advantages of fluorescence imaging over the techniques of atomic force microscopy and electron microscopy for studying biological structures, which include imaging of large fields of view in aqueous environments, specific identification of protein(s) of interest by fluorescent labeling, low perturbation of the system, and the ability to image living systems in near real-time (limited by the time required for super-resolution sequential imaging). This dissertation describes the application of single-molecule and super-resolution fluorescence imaging to studying the huntingtin (Htt) protein aggregates that are a hallmark of Huntington's disease and that have been implicated in the pathogenesis of the disease. The intricate nanostructures formed by fibrillar Htt aggregates in vitro and the sub-diffraction widths of individual fibers mark the amyloids as important targets for high-resolution optical imaging. The characterization of Htt aggregate species is critical for understanding the mechanism of Huntington's disease and identifying potential therapies. Following an introduction to single-molecule, super-resolution imaging and Huntington's disease in Chapter 1, Chapter 2 describes the single-molecule methods, experimental techniques, Htt protein sample preparations, and data analysis performed in this dissertation. Chapter 3 discusses the development of super-resolution imaging of Htt protein aggregates and the validation of the images by atomic force microscopy. Chapter 4 continues the study of Htt by one- and two-color super-resolution with imaging of Htt protein aggregates over time from the initial protein monomers to the large aggregate assemblies of amyloid fibers. In Chapter 5, I detail our progress to-date in studying the earliest stages of Htt aggregation using zero-mode waveguide technology. Chapter 6 concludes the dissertation with a discussion of the results from additional projects comprising the effect of chaperonin proteins on Htt aggregation, extension of super-resolution Htt imaging to three dimensions, and cellular imaging of Htt aggregates. The future directions for these exciting projects are summarized with the expectation that research efforts directed in these areas will contribute to our understanding of Htt aggregation and Huntington's disease.
  • Matthew Herbert Larson.
    Transcription by RNAP is highly regulated in both prokaryotic and eukaryotic cells, and the ability of the cell to differentiate and respond to its environment is largely due to this regulation. During elongation, for example, RNAP is known to momentarily halt in response to certain cellular signals, and this pause state has been implicated in the regulation of gene expression in both prokaryotic and eukaryotic organisms. In addition, once RNAP reaches the end of a gene, it must reliably terminate and release the newly-transcribed RNA, providing another potential point of regulation within different cell types. Both of these steps are crucial to ensure proper gene expression. In this dissertation, I focus on transcription elongation by both prokaryotic and eukaryotic RNA polymerases, as well as their regulation through pausing and termination. To probe the role of RNA hairpins in transcriptional pausing, a novel single-molecule "RNA-pulling" assay was used to block the formation of secondary structure in the nascent transcript. Force along the RNA did not significantly affect transcription elongation rates, pause frequencies, or pause lifetimes, indicating that short "ubiquitous" pauses are not a consequence of RNA hairpins. Force-based single-molecule techniques were also used to study the mechanism and energetics of transcription termination in bacteria. The data suggest two separate mechanisms for termination: one that involves hypertranslocation of RNAP along the DNA, and one that involves shearing of the RNA:DNA hybrid within the enzyme. In addition, a quantitative energetic model is presented that successfully predicts the termination efficiency of both wild-type and mutant terminators. Finally, the implementation of a novel optical-trapping assay capable of directly observing transcription by eukaryotic RNA polymerase II (RNAPII) molecules is described. This approach was used to probe the RNAPII nucleotide-addition cycle, as well as the role of the trigger loop (a conserved subdomain) in elongation. The results are consistent with a Brownian ratchet model of elongation which incorporates a secondary NTP binding site, and the trigger loop was found to modulate translocation, NTP binding, and catalysis, as well as substrate selection and mismatch recognition by RNAPII.
  • Peter Caton Anthony.
    Nucleic acids--DNA and RNA--are critical to life, involved in the storage and decoding of genetic information in the cell as well as the regulation and catalysis of specific biological processes. The function of a nucleic acid molecule is determined in large part by the structure it adopts, which in turn depends on its sequence. The mechanisms of sequence-directed nucleic acid folding remain incompletely understood, particularly for large RNA molecules. The work presented in this thesis uses single-molecule optical-trapping techniques to study nucleic acid folding, where reversible folding is induced and measured in individual molecules through the application of force. In Chapter 2 we demonstrate direct measurement of the full folding energy landscapes of DNA hairpins, which comprise a model system for studying nucleic acid secondary structure, and show how such landscapes are sensitive to sequence. In Chapter 3 we study the electrostatics of DNA hairpin folding by measuring trends in folding energies under different ionic conditions and comparing these trends with those predicted by Poisson-Boltzmann theory. Finally, in Chapter 4 we examine folding of the TPP riboswitch aptamer, an RNA molecule with complex secondary structure that also adopts tertiary structure upon binding a small-molecule ligand. We measured the folding energy landscape of the aptamer and perturbations of this landscape resulting from mutations and ligand binding, and propose a kinetic model to describe the coupling between aptamer folding and ligand binding. Taken together, the results presented here demonstrate the usefulness of the energy landscape framework for characterizing nucleic acid folding in conjunction with single-molecule measurements.
  • 2013From: Springer
    Andres F. Oberhauser, editors.
    Single-molecule measurement techniques are providing fundamental information on the structure and function of biomolecules and are becoming an indispensable tool to understand how proteins work. During the last two decades, this field has grown at an almost exponential rate in terms of biological and biophysical applications. Single-molecule techniques have opened new fields of science that are at the crossroads of several disciplines such as biology, physics, chemistry, material science and computer science. These methods are often the approach of choice to clarify and better understand the structure and function of single proteins. This volume consists of up-to-date and comprehensive reviews of important and timely applications of different biological problems tackled by single-molecule methods; it also covers basic principles of operation, experiment and theory.In Single-molecule Studies of Proteins, expert researchers discuss the successful application of single-molecule techniques to a wide range of biological events, such as the imaging and mapping of cell surface receptors, the analysis of the unfolding and folding pathways of single proteins, the analysis interaction forces between biomolecules, the study of enzyme catalysis or the visualization of molecular motors in action. The chapters are aimed at established investigators and post-doctoral researchers in the life sciences wanting to pursue research in the various areas in which single-molecule approaches are important; this volume also remains accessible to advanced graduate students seeking similar research goals.
  • Kirsten Linnea Frieda.
    RNA--a ubiquitous and versatile type of biopolymer that is critically involved in many of life's molecular processes--is produced sequentially in single-stranded form during transcription by RNA polymerase and has the propensity to fold back on itself into interesting structures of functional import. In nature, riboswitches are elegant examples of structured RNA that adopt alternate conformations in response to ligand binding and thereby affect gene expression. We have been able to probe riboswitch conformations in novel detail using single-molecule optical-trapping techniques. These experimental approaches supply a unique perspective on folding since the ability to apply force provides an effective handle on the real-time state of individual RNA molecules and a means of modulating that state. In this dissertation, I focus on three studies that explore adenine riboswitch conformations and mechanisms. Specifically, in the first, we dissect the folding landscape of the aptamer (ligand-binding domain) of an adenine riboswitch. Extending this endeavor to full riboswitch sequences, we probe the interplay of a riboswitch aptamer with its downstream expression platform (which executes the switch's regulatory role), and develop methods to do so both during and after transcription. The second study takes full advantage of the latter ability: In a complete adenine riboswitch controlling transcription, we directly observe cotranscriptional folding of the nascent RNA in which the adopted conformation dictates whether or not to terminate transcription. Finally, in a different adenine riboswitch controlling translation, we investigate switch conformational changes and identify a series of competing structural elements that kinetically trap the riboswitch conformation, implying that the initial, cotranscriptional fold of the riboswitch may determine its gene regulatory state. These efforts enhance our understanding of folding architectures in riboswitches, specifically, and in RNA, more broadly. They further highlight the importance of cotranscriptional folding, providing a novel window into the nascent development of RNA conformations.
  • edited by Paul R. Selvin, Taekjip Ha.
    PrintStatus: Not Checked OutLane Catalog Record
    The new era of biology in singulo / T. Ha and P.R. Selvin -- Single-molecule FRET with total internal reflection microscopy / C. Joo and T. Ha -- In vitro and in vivo FIONA and other acronyms for watching molecular motors walk / P.R. Selvin, T. Lougheed, M.T. Hoffman, H. Park, H. Balci, B.H. Blehm, and E. Toprak -- Colocalization of fluorescent probes: Accurate and precise registration with nanometer resolution / L.S. Churchman and J.A. Spudich -- Alternating-laser excitation of single molecules / A.N. Kapanidis, M. Heilemann, E. Margeat, X. Kong, E. Nir, and S. Weiss -- Orientation and rotational motions of single molecules by polarized total internal reflection fluorescence microscopy / J.F. Beausang, Y. Sun, M.E. Quinlan, J.N. Forkey, and Y.E. Goldman -- Imaging gene expression in living cells at the single-molecule level / J. Xiao, J. Elf, G.-W. Li, J. Yu, and X.S. Xie -- Single-virus tracking in live cells / M.J. Rust, M. Lakadamyali, B. Brandenburg, and X. Zhuang -- Ultrasensitive imaging in live cells using fluorescent quantum dots / S. Courty and M. Dahan -- Imaging real-time gene expression in living systems / A.L. Wells, J.S. Condeelis, R.H. Singer, and D. Zenklusen -- Single-molecule imaging of stochastic signaling events in living cells / S. Matsuoka, Y. Miyanaga, T. Yanagida, and M. Ueda -- Fluorescence correlation spectroscopy in vitro and in vivo / E. Haustein and P. Schwille -- Optical traps to study properties of molecular motors / J.A. Spudich, S.E. Rice, R.S. Rock, T.J. Purcell, and H.M. Warrick -- High-resolution dual-trap optical tweezers with differential detection / C. Bustamante, Y.R. Chemla, and J.R. Moffitt -- Imaging and nanomanipulation of an actomyosin motor / S. Nishikawa, T. Komori, T. Ariga, T. Okada, M. Morimatsu, Y. Ishii, and T. Yanagida -- Single-molecule studies using magnetic traps / T. Lionnet, J.-F. Allemand, A. Revyakin, T.R. Strick, O.A. Saleh, D. Bensimon, and V. Croquette -- Probing polysaccharide and protein mechanics by atomic force microscopy / M. Rabbi and P.E. Marszalek -- Single-molecule analysis of nucleic acids and DNA-protein interactions using nanopores / M. Wanunu and A. Meller -- Single-molecule gold-nanoparticle tracking with high temporal and spatial resolution and without an applied load / A.R. Dunn and J. A. Spudich -- Advances in surface-based assays for single molecules / P.M. Fordyce, M.T. Valentine, and S.M. Block -- Hydrodynamic flow-stretching assay for single-molecule studies of nucleic acid-protein interactions / C.M. Schroeder, P.C. Blainey, S. Kim, and X.S. Xie.
  • 2010From: ScienceDirect
    edited by Nils G. Walter.
    Star polymer surface passivation for single-molecule detection / Jürgen Groll and Martin Moeller -- Azide-specific labeling of biomolecules by Staudinger-Bertozzi ligation: phosphine derivatives of fluorescent probes suitable for single-molecule fluorescence spectroscopy / Anirban Chakraborty ... [et al.] -- Preparation of fluorescent pre-mRNA substrates for an smFRET study of pre-mRNA splicing in yeast / John Abelson, Haralambos Hadjivassiliou and Christine Guthrie -- Nanovesicle trapping for studying weak protein interactions by single-molecule FRET / Jaime J. Benítez, Aaron M. Keller and Peng Chen -- Droplet confinement and fluorescence measurement of single molecules / Lori S. Goldner, Ana M. Jofre and Jianyong Tang -- Single-molecule fluorescence spectroscopy using phospholipid bilayer nanodiscs / Abhinav Nath ... [et al.] -- Single-molecule spectroscopy using microfluidic platforms / Samuel Kim and Richard N. Zare -- Detection of protein-protein interactions in the live cell plasma membrane by quantifying prey redistribution upon bait micropatterning / Julian Weghuber ... [et al.] -- Analysis of complex single-molecule FRET time trajectories / Mario Blanco and Nils G. Walter -- Single-molecule fluorescence studies of intrinsically disordered proteins / Allan Chris M. Ferreon ... [et al.] -- Measuring the energetic coupling of tertiary contacts in RNA folding using single molecule fluorescence resonance energy transfer / Max Greenfield and Daniel Herschlag -- A highly purified, fluorescently labeled in vitro translation system for single-molecule studies of protein synthesis / Jingyi Fei ... [et al.] -- Watching individual proteins acting on single molecules of DNA / Ichiro Amitani ... [et al.] -- DNA curtains for high-throughput single-molecule optical imaging / Eric C. Greene ... [et al.] -- Scanning FCS for the characterization of protein dynamics in live cells / Zdenĕk Petrás̆ek, Jonas Ries and Petra Schwille -- Observing protein interactions and their stoichiometry in living cells by brightness analysis of fluorescence fluctuation experiments / Yan Chen ... [et al.] -- Detection of individual endogenous RNA transcripts in situ using multiple singly labeled probes / Arjin Raj and Sanjay Tyagi -- Single mRNA tracking in live cells / Hye Yoon Park, Adina R. Buxbaum and Robert H. Singer -- Single-molecule sequencing: sequence methods to enable accurate quantitation / Christopher Hart ... [et al.] -- Real-time DNA sequencing from single polymerase molecules / Jonas Korlach ... [et al.].
    Also available: Print – 2010
  • 2010From: ScienceDirect
    edited by Nils G. Walter.
    Also available: Print – 2010
  • 2012From: Springer Protocols
    edited by James L. Keck.
    Functions of single-strand DNA-binding proteins in DNA replication, recombination, and repair / Aimee H. Marceau -- Structural diversity based on variability in quaternary association. a case study involving eubacterial and related SSBs / S.M. Arif and M. Vijayan -- SSB binding to ssDNA using isothermal titration calorimetry / Alexander G. Kozlov and Timothy M. Lohman -- SSB-DNA binding monitored by fluorescence intensity and anisotropy / Alexander G. Kozlov, Roberto Galletto, and Timothy M. Lohman -- Single-molecule analysis of SSB dynamics on single-stranded DNA / Ruobo Zhou and Taekjip Ha -- Sample preparation methods to analyze DNA-induced structural changes in replication protein A / Chris A. Brosey, Susan E. Tsutakawa, and Walter J. Chazin -- Structural studies of SSB interaction with RecO / Mikhail Ryzhikov and Sergey Korolev -- Investigation of protein-protein interactions of single-stranded DNA-binding proteins by analytical ultracentrifugation / Natalie Naue and Ute Curth -- Ammonium sulfate co-precipitation of SSB and interacting proteins / Aimee H. Marceau -- Analyzing Interactions Between SSB and proteins by the use of fluorescence anisotropy / Duo Lu -- Far western blotting as a rapid and efficient method for detecting interactions between DNA replication and DNA repair proteins / Brian W. Walsh, Justin S. Lenhart, Jeremy W. Schroeder, and Lyle A. Simmons -- Methods for analysis of SSB-protein interactions by SPR / Asher N. Page and Nicholas P. George -- Use of native gels to measure protein binding to SSB / Jin Inoue and Tsutomu Mikawa -- Identification of small molecules that disrupt SSB-protein interactions using a high-throughput screen / Douglas A. Bernstein -- Detection of posttranslational modifications of replication protein A / Cathy S. Hass, Ran Chen, and Marc S. Wold -- Detecting posttranslational modifications of bacterial SSB proteins / Dusica Vujaklija and Boris Macek -- Fluorescent SSB as a reagentless biosensor for single-stranded DNA / Katy Hedgethorne and Martin R. Webb -- Fluorescent single-stranded DNA-binding proteins enable in vitro and in vivo studies / Piero R. Bianco, Adam J. Stanenas, Juan Liu, and Christopher S. Cohan -- Use of fluorescently tagged SSB proteins in in vivo localization experiments / Rodrigo Reyes-Lamothe.
  • 2009From: Springer
    Janine E. Janosky, Shelley L. Leininger, Michael P. Hoerger, Terry M. Libkuman.
  • Kevin David Welsher.
    The near infrared range has long been known to be advantageous for biological imaging and sensing applications. In particular, the second near infrared window (1000 nm -- 1400 nm, NIR II) is characterized by low endogenous autofluorescence and deep tissue penetration due to reduced tissue scatter. To address the dearth of fluorophores in this window, this work focuses on utilizing the intrinsic near infrared photoluminescence of semiconducting single walled carbon nanotubes (SWNTs) to take advantage of this unique spectral region. First, SWNTs are made bio-inert and applied as fluorescent probes for highly specific cellular targeting using antibodies such as Rituxan and Herceptin. These probes were then used for the first whole animal fluorescent imaging using SWNTs in vivo following tail vein injection, including the observation of high SWNT accumulation in tumors. By implementing a surfactant exchange method to improve the fluorescence yield of SWNTs solubilized by phospholipid-polyethylene glycol, high magnification intravital microscopy of tumor vessels beneath thick skin was achieved. Further improvements were made to improve the fluorescence yield of the SWNT probes by utilizing a density gradient separation method which removed poorly fluorescent short tubes and nanotube bundles. Another separation method, ion-exchange chromatography was applied to isolate single chirality SWNTs and perform multicolor NIR imaging in vitro and in vivo. Finally, these bright, biocompatible nanotube fluorophores were used to achieve video rate imaging of mice in vivo during tail vein injection for dynamic contrast enhanced imaging through principal component analysis. The emission in the NIR II region allowed crisp anatomical resolution, confirmed by mock tissue phantom studies and Monte Carlo simulation.
  • 2000From: ScienceDirect
    edited by Lester Packer, Helmut Sies ; editorial advisory board, Jean Cadet ... [et al.]
    Also available: Print – 2000
  • 2015From: Springer
    Ronald Younes, Nabih Nader, Georges Khoury, editors.
    Placement of endosseous implants in the posterior maxilla is often difficult because of a lack of supporting bone. Sinus augmentation procedures have therefore been extensively used for the treatment of the edentulous atrophic posterior maxilla prior to implant placement. This book describes in detail the most widely used sinus grafting techniques as well as some innovative variations, with full coverage of both lateral and crestal approaches. A key aim is to assist the practitioner in selecting the appropriate sinus grafting technique based on the evaluation of a number of parameters that are described in detail and codified in a simple and practical way. Up-to-date information is also provided on grafting materials and on potential complications of sinus augmentation procedures and their treatment.
  • by Botha De Meillon, David H.S. Davis and Felicity Hardy.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2017From: Oxford Medicine Online
    Michael J. Aminoff, MD, DSc, FRCP, Professor of Neurology, School of Medicine, University of California, San Francisco, California.
    An introductory snapshot -- In the beginning -- London and the Great Windmill Street School -- Anatomy of the expression of emotions -- Behind the glories of war -- Swings and roundabouts -- In and out of the central nervous system -- The organization of the nervous system -- Clinical observations on the nervous system -- For God and country -- New classrooms : old struggles -- The ebbing tide -- To each his due.
  • 2016From: Springer Protocols
    edited by Kato Shum and John Rossi.
    Synthesis and conjugation of small interfering ribonucleic neutral SiRNNs / Alexander S. Hamil and Steven F. Dowdy - - Liver-targeted SiRNA delivery using biodegradable poly(amide) polymer conjugates / Stephanie E. Barrett and Erin N. Guidry -- PepFect6 mediated SiRNA delivery into organotypic cultures / Suvarna Dash-Wagh, Ülo Langel, and Mats Ulfendahl -- Highly efficient SiRNA delivery mediated by cationic helical polypeptides and polypeptide-based nanosystems / Lichen Yin, Nan Zheng, and Jianjun Cheng -- Disulfide-bridged cleavable PEGylation of poly- L -lysine for SiRNA delivery / Min Tang ... [et al.] -- Preparation of a cyclic RGD : modified liposomal SiRNA formulation for use in active targeting to tumor and tumor endothelial cells / Yu Sakurai, Tomoya Hada, and Hideyoshi Harashima -- Multifunctional envelope-type nano device containing a pH-sensitive cationic lipid for efficient delivery of short interfering RNA to hepatocytes in vivo / Yusuke Sato, Hideyoshi Harashima, and Michinori Kohara -- Bioreducible poly (beta-amino ester)s for intracellular delivery of SiRNA / Kristen L. Kozielski and Jordan J. Green -- Preparation of polyion complex micelles using block copolymers for SiRNA delivery / Hyun Jin Kim ... [et al.] -- Delivery of small interfering RNAs to cells via exosomes / Jessica Wahlgren ... [et al.] -- Dendrimer nanovectors for SiRNA delivery / Xiaoxuan Liu and Ling Peng -- Chitosan nanoparticles for SiRNA delivery in vitro / Héloïse Ragelle ... [et al.] -- Non-covalently functionalized of single-walled carbon nanotubes by DSPE-PEG-PEI for SiRNA delivery / King Sun Siu ... [et al.] -- SiRNA in vivo-targeted delivery to murine dendritic cells by oral administration of recombinant yeast / Kun Xu ... [et al.] -- TLR9-targeted SiRNA delivery in vivo / Dewan Md Sakib Hossain ... [et al.] -- Aptamer-MiRNA conjugates for cancer cell-targeted delivery / Carla L. Esposito, Silvia Catuogno, and Vittorio de Franciscis -- Method for confirming cytoplasmic delivery of RNA aptamers / David D. Dickey ... [et al.] -- Hapten-binding bispecific antibodies for the targeted delivery of SiRNA and SiRNA-containing nanoparticles / Irmgard S. Thorey ... [et al.] -- Stable delivery of CCR5-directed shRNA into human primary peripheral blood mononuclear cells and hematopoietic stem/progenitor cells via a lentiviral vector / Saki Shimizu, Swati Seth Yadav, and Dong Sung An -- Hepatic delivery of artificial micro RNAs using helper- dependent adenoviral vectors / Carol Crowther, Betty Mowa, and Patrick Arbuthnot -- Intravascular AAV9 administration for delivering RNA silencing constructs to the CNS and periphery / Brett D. Dufour and Jodi L. McBride -- Efficient gene suppression in dorsal root ganglia and spinal cord using adeno-associated virus vectors encoding short-hairpin RNA / Mitsuhiro Enomoto ... [et al.] -- Synthetic SiRNA delivery : progress and prospects / Thomas C. Roberts ... [et al.].
  • 2012From: Springer Protocols
    edited by Debra J. Taxman.
    What parameters to consider and which software tools to use for target selection and molecular design of small interfering RNAs / Olga Matveeva -- Methods for selecting effective siRNA target sequences using a variety of statistical and analytical techniques / Shigeru Takasaki -- Designing functional siRNA with reduced off-target effects / Yuki Naito and Kumiko Ui-Tei -- Design and screening of siRNAs against highly structured RNA targets / Neda Nasheri, John Paul Pezacki, and Selena M. Sagan -- Engineering small interfering RNAs by strategic chemical modification / Jesper B. Bramsen and Jørgen Kjems -- Design, selection, and evaluation of highly specific and functional siRNA incorporating unlocked nucleobase analogs / Narendra Vaish and Pinky Agarwal -- Design, preparation and evaluation of asymmetric small interfering RNA for specific gene silencing in mammalian cells / Chanil Chang [and others] -- Design of nuclease-resistant fork-like small interfering RNA (fsiRNA) / Elena L. Chernolovskaya and Marina A. Zenkova -- Designing dual-targeting siRNA duplexes having two active strands that combine siRNA and MicroRNA-like targeting / Pal Sætrom -- Strategies for designing and Validating immunostimulatory siRNAs / Michael P. Gantier -- Designing efficient and specific endoribonuclease-prepared siRNAs / Vineeth Surendranath [and others] -- Short hairpin RNA-mediated gene silencing / Luke S. Lambeth and Craig A. Smith -- Design of lentivirally expressed siRNAs / Ying Poi Liu and Ben Berkhout -- Bifunctional short hairpin RNA (bi-shRNA) : design and pathway to clinical application / Donald D. Rao [and others] -- Design and chemical modification of synthetic short shRNAs as potent RNAi triggers / Anne Dallas and Brian H. Johnston -- Production and application of long dsRNA in mammalian cells / Katerina Chalupnikova, Jana Nejepinska, and Petr Svoboda -- Design of RNAi reagents for invertebrate model organisms and human disease vectors / Thomas Horn and Michael Boutros -- Construction of shRNA expression plasmids for silkworm cell lines using single-stranded DNA and Bst DNA polymerase / Hiromitsu Tanaka -- Designing effective amiRNA and multimeric amiRNA against plant viruses / Muhammad Fahim and Philip J. Larkin -- Downregulation of plant genes with miRNA-induced gene silencing / Felipe Fenselau de Felippes.
  • Victoria Antonina Rafalski.
    While the adult mammalian brain has a relatively limited regenerative capacity, it does contain pools of neural stem and progenitor cells that can give rise to new neurons and glia. The mechanisms that govern the production of new neurons in the adult brain are beginning to be well understood, but much less is known about the production of other cell lineages, in particular oligodendrocytes, from adult neural stem cells. Given the importance of oligodendrocytes in myelination, how they are generated in the adult brain is a question of fundamental importance for both normal and pathological conditions. Here we show that loss of SIRT1, a deacetylase that is crucial for metabolism and neuroprotection, enhances the production of both neural stem cells and oligodendrocyte progenitor cells in the adult brain and in vitro. Conditional deletion of SIRT1 in adult neural stem cells reveals a cell-autonomous action of SIRT1 in the generation of glia in the niche surrounding the subventricular zone. We find evidence that SIRT1 loss may alter the pool of proliferating oligodendrocyte progenitor cells by controlling the PDGF receptor a (PDGFR a) signaling pathway. SIRT1 loss increases acetylation of lysine 9 of histone H3 at the Pdgfra gene locus, affecting Pdgfra expression and activation of downstream PI3K-Akt and p38 MAPK signaling pathways in adult neural stem and progenitor cells. The observation that a drug-targetable deacetylase and downstream signaling pathways impact oligodendrocyte expansion may facilitate the generation of oligodendrocytes for stem cell therapies to treat injury and demyelinating diseases.
  • 2016From: Springer
    Riekelt H. Houtkooper, editor.
    1. Biochemistry and enzymology of sirtuins -- 2. NAD as a pharmacological tool to boost sirtuin activity -- 3. Protein lysine acylation: abundance, dynamics and function -- 4. SIRT1 in metabolic health and disease -- 5. Deacetylation by SIRT3 relieves inhibition of mitochondrial protein function -- 6. SIRT5 reveals novel enzymatic activities of sirtuins -- 7. Diverse roles of SIRT6 in mammalian healthspan and logevity -- 8. Sirtuins in cancer, emerging role as modulators of metabolic reprogramming -- 9. Sirtuins as metabolic modulators of muscle plasticity -- 10. Sirtuins and aging -- 11. Sirtuins and the circadian clock: epigenetic and metabolic crosstalk -- 12. Sirtuin activation by small molecules -- 13. Sirtuins: a future perspective -- Index.
  • 2013From: Springer Protocols
    edited by Matthew D. Hirschey.
    Introduction: sirtuins in aging and diseases / Leonard Guarente -- Sirtuins in yeast: phenotypes and tools / Scott Tsuchiyama [and four others] -- C. elegans sirtuins / Mohan Viswanathan and Heidi A. Tissenbaum -- Genetic and biochemical tools for investigating sirtuin function in Drosophila melanogaster / Jason G. Wood, Rachel Whitaker, and Stephen L. Helfand -- Generating mammalian sirtuin tools for protein-interaction analysis / Kathleen A. Hershberger [and three others] -- Mass spectrometry-based detection of protein acetylation / Yu Li [and three others] -- SILAC-based quantification of Sirt1-responsive lysine acetylome / Yue Chen, Gozde Colak, and Yingming Zhao -- Targeted quantitation of acetylated lysine peptides by selected reaction monitoring mass spectrometry / Matthew J. Rardin, Jason M. Held, and Bradford W. Gibson -- Identification of deacetylase substrates with the biotin switch approach / J. Will Thompson, Alex Robeson, and Joshua L. Andersen -- Assaying chromatin sirtuins / Lei Zhong [and four others] -- Measurement of sirtuin enzyme activity using a substrate-agnostic fluorometric nicotinamide assay / Basil P. Hubbard and David A. Sinclair -- Detecting sirtuin-catalyzed deacylation reactions using 32P-labeled NAD and thin-layer chromatography / Anita Zhu, Xiaoyang Su, and Hening Lin -- Chemical acetylation and deacetylation / Kristofer S. Fritz -- Accurate measurement of nicotinamide adenine dinucleotide (NAD+) with high-performance liquid chromatography / Jun Yoshino and Shin-ichiro Imai -- In vivo measurement of the acetylation state of sirtuin substrates as a proxy for sirtuin activity / John Dominy, Pere Puigserver, and Carles Cantó -- Oxygen flux analysis to understand the biological function of sirtuins / Dongning Wang [and three others] -- The emerging links between sirtuins and autophagy / In Hye Lee, Jeanho Yun, and Toren Finkel -- Methods to study the role of sirtuins in genome stability / Paloma Martínez-Redondo and Alejandro Vaquero -- Circadian measurements of sirtuin biology / Kathryn Moynihan Ramsey [and five others] -- Utilizing calorie restriction to evaluate the role of sirtuins in healthspan and lifespan of mice / Jessica Curtis and Rafael de Cabo.
  • 2010From: Springer
    R. Nieuwenhuys, J. Voogd, C. Van Huijzen.
  • 2013From: Springer
    Sylvaine Renault, Philippe Duchateau [editors].
    The post-genomic era has brought new challenges and opportunities in all fields of the biology. In this context, several genome engineering technologies have emerged that will help deciphering genes function by as well as improve gene therapy strategies. Genomic modifications such as knock-in, knock-out, knock-down, sequence replacement or modification can today be routinely performed. However, in front of this large palette of methodologies scientists may experience difficulties to gather useful information{u2019}s scattered within the literature. This book aims to present the state of this field from basic mechanisms of site-directed modifications to their applications in a wide range of organisms such as bacteria, yeast, plants, insects, mammals. It will discuss the problems encountered when using the random integration strategy and present the recent advances made in targeted genome modification. Technologies based on Zinc Finger nucleases, Meganucleases, TALEN, CRE and FLP recombinase, {uF06A}C31 integrase, transposases and resolvases are fully detailed with their strengths and weaknesses. All these information{u2019}s will help students and experienced researchers to understand and choose the best technology for their own purposes.
  • 2015From: Springer Protocols
    edited by Arnaud Gautier, Marlon J. Hinner.
    How FlAsH got its dparkle : historical recollections of the biarsenical-tetracysteine tag / B. Albert Griffin, Stephen R. Adams, and Roger Y. Tsien - - Site-specific protein labeling in the pharmaceutical industry : experiences from novartis drug discovery / Lukas Leder -- Getting across the cell membrane : an overview for small molecules, peptides, and proteins / Nicole J. Yang and Marlon J. Hinner -- Considerations and protocols for the synthesis of custom protein labeling probes / Ivan R. Corrêa Jr. -- 2-Cyanobenzothiazole (CBT) condensation for site- specific labeling of proteins at the terminal cysteine residues / Lina Cui and Jianghong Rao -- Fluorescent labeling for patch-clamp fluorometry (PCF) measurements of real-time protein motion in ion channels / Thomas K. Berger and Ehud Y. Isacoff -- Fluorescent labeling of SNAP-tagged proteins in cells / Gražvydas Lukinavičius, Luc Reymond, and Kai Johnsson -- Halotag technology for specific and covalent labeling of fusion proteins / Hélène A. Benink and Marjeta Urh -- Ligation of synthetic peptides to proteins using semisynthetic protein trans-splicing / Julian C.J. Matern ... [et al.] -- Chemical-tag labeling of proteins using fully recombinant split inteins / Anne-Lena Bachmann ... [et al.] -- Phage selection assisted by Sfp phosphopantetheinyl transferase-catalyzed site-specific protein labeling / Bo Zhao ... [et al.] -- Site-specific biotinylation of purified proteins using BirA / Michael Fairhead and Mark Howarth -- Site-specific labeling of proteins via sortase : protocols for the molecular biologist / Maximilian Wei-Lin Popp -- BONCAT: metabolic labeling, click chemistry, and affinity purification of newly synthesized proteomes / Peter Landgraf, Elmer R. Antileo, Erin M. Schuman, and Daniela C. Dieterich -- Genetic encoding of unnatural amino acids for labeling proteins / Kathrin Lang , Lloyd Davis, and Jason W. Chin -- Labeling proteins by affinity-guided DMAP chemistry / Tomonori Tamura and Itaru Hamachi -- Ligand-directed tosyl chemistry for selective native protein labeling in vitro, in cells, and in vivo / Shinya Tsukiji and Itaru Hamachi.
  • 2002From: Knovel
    Richard P. Pohanish, editor.
  • 2007From: CRCnetBASE
    Brian K. Nunnally, John S. McConnell.
    The enormous initial mistake -- The origins of six sigma -- Evolution -- Revolution -- Paradox -- Action and reaction -- Close enough or on target? -- Make more-- faster! -- Case studies -- The camera always lies -- Keeping it simple -- Why use control charts? -- Average and range control charts -- Origins and theory -- Charts for individuals -- Practical considerations -- Improving laboratories -- Beyond compliance.
  • Armando Ricardo Hernández.
    This thesis project describes the synthesis and use of size-expanded ribonucleic acids (xRNAs) as unnatural components in small interfering RNAs (siRNAs), which serve as a novel set of steric probes for investigating and identifying size restrictions that exist in the active site of the RNA-induced silencing complex (RISC), a critical protein complex in the RNA interference (RNAi) mechanism. xRNAs are analogous to natural RNAs, in which they retain canonical Watson Crick base-pairing groups, except their nucleobases are expanded linearly by 2.4 Å via benzo-fusion. In this report, the synthesis of the entire set of four xRNA nucleosides and their photophysical properties are described. Two of the xRNA nucleosides (i.e. rxA and rxU) are then converted to their corresponding phosphoramidites for use in automated RNA synthesis to synthesize various sets of xRNA-substituted siRNA strands for biophysical and biological studies. RNAi activity studies in HeLa cells using a firefly/Renilla luciferase dual reporter assay showed that xRNA substitutions in the antisense strand displayed poor RNAi activity in the middle of the sequence (positions 7-14) but were generally well tolerated near the 5'- and 3'-ends. Most significantly, single xRNA substitutions at the 3'-end showed RNAi activity that was more potent than that of unmodified siRNAs. Thermal denaturation studies revealed small changes in melting temperature (+1.4 to --5.0 °C); xRNA substitutions in the middle were found to be more thermodynamically destabilizing whereas the ends were shown to be stabilizing. Serum stability studies showed that xRNA-containing siRNAs have longer half-lives in human serum than unmodified siRNAs. Finally, xRNA-substituted siRNA strands and duplexes showed interesting position-dependent fluorescent properties, while CD spectroscopy experiments revealed that xRNA-substituted siRNAs does not greatly distort the native A-form helical structure of the duplexes. Taken together, the data demonstrate the utility of xRNA nucleobases as size-expanded mechanistic probes for RNAi research.
  • 2016From: ClinicalKey
    edited by Roberto Gerli ; co-edited by Elena Bartoloni, Alessia Alunno.
    Introduction : history of Sjögren's syndrome -- Clinical features -- Management of Sjögren's syndrome -- Classification criteria for Sjögren's syndrome -- Imaging procedures useful for the diagnosis of Sjögren's syndrome : abnormalities of the major salivary glands -- Sjögren's syndrome--associated lymphoma -- Spontaneous and inducible animal models of Sjögren's syndrome -- Genetics, genomics, gene expression profiling, and epigenetics in Sjögren's syndrome -- Autoantigens and autoantibodies in the pathogenesis of Sjögren's syndrome -- Sjögren's syndrome and environmental factors -- Histology of Sjögren's syndrome -- Glandular epithelium : innocent bystander or leading actor? -- T cells in the pathogenesis of Sjögren's syndrome : more than just Th1 and Th2 -- B lymphocytes in primary Sjögren's syndrome -- Cytokines, chemokines, and the innate immune system in Sjögren's syndrome -- Autoantibodies and autoantigens in Sjögren's syndrome -- Outcome measures in Sjögren's syndrome and perspectives in clinical trial design -- Novel therapeutic strategies in Sjögren's syndrome : b-cell targeting -- Novel therapeutic strategies in Sjögren's syndrome : t-cell targeting -- New biological avenues for Sjögren's syndrome.
  • 2012From: Springer
    Manuel Ramos-Casals, John H. Stone, Haralampos M. Moutsopoulos, editors.
  • 2011From: Springer
    Robert I. Fox, Carla M. Fox, editors.
    Introduction -- A Note from Sweden: Recollection of Henrik Sjögren -- Myths, Pearls, and Tips Regarding Sjögren's Syndrome -- Providing Information to Referring Physicians and Patients -- Current Concepts on Classification Criteria and Disease Status Indexes in Sjögren's Syndrome -- Histopathology and Glandular Biopsies in Sjögren's Syndrome -- Imaging Technology in Sjögren's Syndrome: Non-invasive Evaluation of the Salivary Glands -- Genomics and Viruses in Sjögren's Syndrome -- Autoantibodies and Autoantigens in Sjögren's Syndrome -- B-cell Epitopes of Sjögren's Syndrome-Related Autoantigens Ro/SSA and La/SSB -- Neurobiology and Hormonal Control of Lacrimal and Salivary Gland Function -- Overview of Management of Dry Eye Associated with Sjögren's Syndrome -- Pathogenesis: Emphasis on Dry Eye and the Role of the Lacrimal Functional Unit in Sjögren's Syndrome -- Oral and Dental Manifestations of Sjögren's Syndrome: Current Approaches to Diagnostics and Therapy -- Etiology and Pathogenesis of Sjögren's Syndrome with Special Emphasis on the Salivary Glands -- Otolaryngologic Manifestations of Sjögren's Syndrome -- Extraglandular Manifestations of Sjögren's Syndrome (SS): Dermatologic, Arthritic, Endocrine, Pulmonary, Cardiovascular, Gastroenterology, Renal, Urology, and Gynecologic Manifestations -- Therapy of Dermatologic, Renal, Cardiovascular, Pulmonary, Gynecologic, Gastro-enterologic, Urologic and Fibromyalgia Manifestations Including Special Considerations at the Time of Surgery -- Current Treatment of Extraglandular Manifestations with Disease-Modifying and Immunosuppressive Agents -- Lymphoproliferation and Lymphoma in Sjögren's Syndrome -- Fatigue, Dryness, and Quality of Life as Clinical Trial Outcomes in Primary Sjögren's Syndrome -- The Neurological Manifestations of Sjögren's Syndrome: Diagnosis and Treatment -- New Approaches for the Management of Dry Mouth in Sjögren's Syndrome in Japan -- New Approaches for the Management of Dry Mouth and Dry Eye in Sjögren's Syndrome in Japan Dry Eye Part -- Sjögren's Syndrome in Australia: Clinical Practice and Research -- Primary Sjögren's Syndrome: Report from India -- Sjögren's Syndrome in China -- Sjögren's Syndrome in China -- Sjögren's Syndrome in Israel: A Scientific Point of View -- Looking into the Future-The EULAR Disease Activity Scores: Toward a Consensual Evaluation of Primary Sjögren's Syndrome -- Looking into the Crystal Ball: Initiatives from the Sjögren's Syndrome Foundation That Will Impact Patient Care -- Biological Treatment for Sjögren's Syndrome -- Looking into the Future-Emerging Therapies Based on Pathogenesis -- Into the Future: Autonomic Neuropathy, MicroRNAs, and Gene Therapy.
  • 2016From: Oxford Medicine Online
    edited Wan-Fai Ng.
    Sjögren's Syndrome summarises current understanding of the pathogenesis of the disease, including advances in the genetics, disease mechanisms, clinical diagnosis and assessment, secondary Sjögren's syndrome, and the role of laboratory investigations and imaging.
  • 2014From: Springer
    Graham Hughes, Shirish Sangle, Simon Bowman.
    Sjögren's Syndrome is slowly being recognised as one of the most common auto-immune diseases, and considered pivotal in the spectrum of auto-immune disorders. Sjögren's Syndrome in Clinical Practice is a unique, concise book which explores important insights into Sjögren's links with other conditions and devotes itself to shedding new light on this disease. Aimed at young medics but also suitable for the informed lay reader, physicians and pharma, Sjögren's Syndrome in Clinical Practice will help with the diagnosis and treatment of this increasingly recognised disorder.
  • 2016From: Ovid
    [edited by] Samir N. Khleif, Olivier Rixe, Roland T. Skeel.
  • 2011From: Springer
    Jennifer C. Love, Sharon M. Derrick, Jason M. Wiersema.
    Skeletal examination method -- Skull fractures -- Rib fractures -- Fractures of the vertebral column, sternum, scapulae, and clavicles -- Long bone fractures -- Healing and interpretation -- Natural disease may mimic child abuse.
  • 2014From: Springer Protocols
    edited by Matthew J. Hilton, University of Rochester Medical Center, Rochester, NY, USA.
    Overview of Skeletal Development -- Overview of Skeletal Repair (Fracture Healing and Its Assessment) -- Generation of Closed Transverse Fractures in Small Animals -- The Murine Femoral Bone Graft Model and a Semi-Automated Histomorphometric Analysis Tool -- Surgical Induction of Posttraumatic Osteoarthirits -- A Mouse Model of Flexor Tendon Repair -- Cartilage Explant Cultures -- Renal Capsule Transplantations to Assay Skeletal Angiogenesis -- Whole Mount Skeletal Staining -- Tips and Techniques for Processing and Sectioning Undecalcified Murine Bone Specimens -- Preparation of Thin Sections from Non-fixed and Undecalcified Hard Tissues Using Kawamoto's Film Method (2012) -- Demineralized Murine Skeletal Histology -- Beta-Galactosidase Staining in the Skeleton -- Whole-Mount In Situ Hybridization on Murine Skeletogenic Tissues -- Non-Radioactive In Situ Hybridization on Skeletal Tissue Sections -- Radioactive In Situ Hybridization to Detect Gene Expression in Skeletal Tissue Sections -- Proliferation Assays (BrdU and EdU) on Skeletal Tissue Sections -- TUNEL Assay on Skeletal Tissue Sections to Detect Apoptosis -- Analysis of Chondrogenesis Using Micromass Cultures of Limb Mesenchyme -- Isolation and Culture of Murine Primary Chondrocytes -- Bone Marrow Stromal Cell Assays : In Vitro and In Vivo -- Isolation and Culture of Neonatal Mouse Calvarial Osteoblasts -- RANKL-Based Osteoclastogenic Assays from Murine Bone Marrow Cells -- Hematopoietic Stem Cell Cultures and Assays.
  • Peter M. Tiidus, editor.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006From: Springer
    edited by Roberto Bottinelli and Carlo Reggiani.
  • 2008From: Springer
    edited by Stefano Schiaffino and Terence Partridge.
  • Richard L. Lieber.
    PrintStatus: Not Checked OutLane Catalog Record
  • Felix S. Chew ; with contributions from Liem T. Bui-Mansfield, Catherine C. Roberts, Michael L. Richardson.
    PrintStatus: Not Checked OutLane Catalog Record
    Approach to trauma -- Trauma in adults : upper extremity -- Trauma in adults : axial skeleton -- Trauma in adults : lower extremity -- Trauma in children -- Imaging of fracture treatment and healing -- Approach to bone lesions -- Malignant and aggressive tumors -- Benign lesions -- Metastatic tumors -- Approach to joint disease -- Inflammatory arthritis -- Noninflammatory joint disease -- Developmental and congenital conditions -- Metabolic and systemic conditions -- Infection and marrow disease -- Postsurgical imaging.
  • 2015From: ClinicalKey
    [edited by] Bruce D. Browner, Jesse B. Jupiter, Christian Krettek, Paul A. Anderson.
    The history of fracture treatment -- Global burden of musculoskeletal injuries -- The challenges of orthopaedic trauma care in the developing world -- Biology and enhancement of skeletal repair -- Biomechanics of fractures -- Closed fracture management -- Principles and complications of external skeletal fixation -- Principles of internal fixation -- Evaluation and treatment of the multi-injured trauma patient -- Initial evaluation of the spine in trauma patients -- Damage control orthopaedic surgery : a strategy for the orthopaedic care of the critically injured patient -- Disaster management -- Occupational hazards in the treatment of orthopaedic trauma -- Medical management of the orthopaedic trauma patient -- Evaluation and treatment of vascular injuries -- Compartment syndromes -- Open fractures -- Soft tissue reconstruction -- Gunshot wounds and blast injuries -- Pathologic fractures -- Osteoporotic fragility fractures -- Surgical site infection prevention -- Diagnosis and treatment of complications -- Chronic osteomyelitis -- Nonunions : evaluation and treatment -- Physical impairment ratings for fractures -- Outcome assessment in orthopaedic traumatology -- Professionalism and the economics of orthopaedic trauma care -- Psychological, social, and functional manifestations of orthopaedic trauma and traumatic brain injury * -- Imaging of spinal trauma -- Pathophysiology and emergent treatment of spinal cord injury -- The timing of management of spinal cord injuries -- Craniocervical injuries -- Subaxial cervical spine trauma -- Thoracolumbar fractures -- Fractures in the ankylosed spine -- Osteoporotic spinal fractures -- Avoiding complications in spine trauma patients -- Principles of orthotic management -- Pelvic ring injuries -- Surgical treatment of acetabular fractures -- Fractures and dislocations of the hand -- Fractures and dislocations of the carpus -- Fractures of the distal radius -- Diaphyseal fractures of the forearm -- Trauma to the adult elbow and fractures of the distal humerus -- Fracture of the humeral shaft -- Proximal humerus fractures and glenohumeral dislocations -- Fractures and dislocations of the clavicle -- Scapula and rib fractures -- Replantation -- Hip dislocations -- Medical management of the patient with hip fracture -- Intracapsular hip fractures -- Intertrochanteric hip fractures -- Posttraumatic reconstruction of the hip joint -- Subtrochanteric fractures of the femur -- Femoral shaft fractures -- Fractures of the distal femur -- Patella fractures and extensor mechanism injuries -- Knee dislocations and soft tissue injuries -- Tibial plateau fractures -- Malunions and nonunions about the knee -- Tibial shaft fractures -- Fractures of the tibial pilon -- Malleolar fractures and soft tissue injuries of the ankle -- Foot injuries -- Posttraumatic reconstruction of the foot and ankle -- Periprosthetic fractures of the lower extremity -- Principles of deformity correction -- Limb salvage and reconstruction -- Amputations in trauma.
  • [edited by] Bruce D. Browner ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. General principles, spine, pelvis -- v. 2. Upper extremity, lower extremity.
  • 2008From: CRCnetBASE
    Erin H. Kimmerle, Jose Pablo Baraybar.
    An Epidemiological approach to forensic investigations of violations to international humanitarian and human rights law -- Differential diagnosis of skeletal trauma -- Blasting injuries -- Blunt force trauma -- Skeletal evidence of torture -- Sharp force trauma -- Gunfire injuries -- Variation in gunfire wounds by skeletal region.
  • [edited by] Neil E. Green, Marc F. Swiontkowski.
    Skeletal growth, development, and healing as related to pediatric trauma / Stephen L. Frick, Eric T. Jones -- Physeal injuries / Manoj Ramachandran, David L. Skaggs -- Pathologic fractures in children / Herbert S. Schwartz, Ginger E. Holt -- The multiply injured child / John H. Wilber, George H. Thompson, Jochen Son-Hing -- Fractures with soft tissue injuries / Sanjeev Sabharwal, Fred F. Behrens -- Complications of fractures in children / Robert N. Hensinger -- Outcomes assessment in children with fractures / James G. Wright, Nancy L. Young -- Fractures and dislocations of the forearm, wrist, and hand / Martin Dolan, Peter M. Waters -- Fractures and dislocations about the elbow / Neil E. Green, Nathan L. Van Zeeland -- Fractures and dislocations about the shoulder / James F. Mooney III, Lawrence X. Webb -- Fractures of the spine / Gregory A. Mencio, Clinton J. Devin -- Fractures and dislocations about the hips and pelvis / Marc F. Swiontkowski -- Fractures of the femoral shaft / Jeffrey Shilt -- Fractures and dislocations about the knee / Lewis E. Zionts -- Fractures of the tibula and fibula / George H. Thompson, Jochen Son-Hing -- Fractures and dislocations of the foot and ankle / Alvin H. Crawford, Mohammed J. Al-Sayyad, Charles T. Mehlman -- Nonaccidental trauma / Jeffrey Shilt, Neil E. Green, Kathryn E. Cramer -- Anesthesia and analgesia for the ambulatory management of children's fractures / Eric C. McCarty, Gregory A. Mencio -- Rehabilitation of the child with multiple injuries / Louise Z. Spierre ... [et al.] -- Skeletal trauma in young adults / Kevin Shea, Eric W. Edmonds, Henry Chambers.
  • Robert A. Burton, M.D.
    "What if what we consider to be reason-based, deliberative judgment is really the product of involuntary mental sensations? In A Skeptic's Guide to the Mind, Dr. Robert Burton takes a close look at the key false assumptions that permeate the field of cognitive science and offers a new way of exploring how our brains generate thought. The essential paradox that drives this cutting-edge theory is that the same mechanisms that prevent understanding the mind also generate a sense that we can attain such understanding. In A Skeptic's Guide to the Mind, Burton presents his theory of the 'mental sensory system'--a system that generates the main components of consciousness: a sense of self, a sense of choice and free will, and how we make moral decisions. Bringing together anecdotes, practical thought experiments, and cutting-edge neuroscience to show how these various strands of thought and mental sensations interact, A Skeptic's Guide to the Mind offers a powerful tool for knowing what we can and cannot say about the mind; how to discern good from bad cognitive science studies; and most importantly, how to consider the moral implications of these studies. This is a pathbreaking model for considering the interaction between conscious and unconscious thought."-- Provided by publisher.
  • 2008From: Ovid
    Cathy Thomas Hess.
    Contributors -- Foreword -- pt. 1. Wound care and prevention -- 1. Skin care and wound prevention strategies -- 2. Assessing and documenting chronic wounds -- 3. Types of chronic wounds -- 4. Laboratory values in chronic wound management -- 5. Developing a skin and wound care formulary -- 6. Tissue load management -- 7. Wound care and the regulatory process -- pt. 2. Skin and wound care products -- Skin care products -- Overview -- Antifungals and antimicrobials -- Liquid skin protectants -- Moisture barriers -- Skin cleansers -- Therapeutic moisturizers -- Wound care products -- Dressings and devices -- Overview -- Alginates -- Antimicrobials -- Collagens -- Composites -- Color illustrations -- Contact layers -- Foams -- Hydrocolloids -- Hydrogels -- Specialty absorptives -- Surgical supplies, miscellaneous -- Transparent films -- Wound fillers -- Other products -- Drugs -- Overview -- Products -- pt. 3. Additional dressings and products -- Overview -- Abdominal dressing holders and binders -- Compression bandage systems -- Conforming bandages -- Elastic bandage rolls -- Gauze, impregnated with other than water, normal saline, or hydrogel, without adhesive border -- Gauze, impregnated with water or normal saline, without adhesive border -- Gauze, nonimpregnated, with adhesive border -- Gauze, nonimpregnated, without adhesive border -- Tapes -- Wound cleansers -- Appendices -- A. Body mass index -- B. Wagner ulcer grade classification -- C. Braden scale -- D. Treatment algorithm for pressure ulcers -- E. Treatment algorithm for arterial ulcers -- F. Treatment algorithm for venous ulcers -- G. Treatment algorithm for diabetic ulcers -- H. Treatment algorithm for diabetic ulcer wound care -- I. Laboratory tests to rule out atypical causes of leg ulcers -- J. Ankle-brachial index use in patients with diabetes -- Manufacturer resource guide -- Selected references -- Index.
  • 2006From: Springer
    Barbara A. Gilchrest, Jean Krutmann, eds.
    1. Recent Demographic Changes and Consequences for Dermatology / Ursula Krämer and Tamara Schikowski, p. 1-8 -- 2. Clinical and Histological Features of Intrinsic versus Extrinsic Skin Aging / Mina Yaar, p. 9-21 -- 3. Ethnic Differences in Skin Aging / Erwin Tschachler and Frederique Morizot, p. 23-31 -- 4. Photoaging of Skin / Jean Krutmann and Barbara Gilchrest, p. 33-43 -- 5. Premature Skin Aging by Infrared Radiation, Tobacco Smoke and Ozone / Peter Schroeder, Stefan Schieke and Akimichi Morita, p. 45-53 -- 6. The Role of Hormones in Intrinsic Aging / Christos Zouboulis and Evgenia Makrantonaki, p. 55-64 -- 7. Permeability and Antioxidant Barriers in Aged Epidermis / Jens Thiele, Chantal Barland, Ruby Ghadially and Peter Elias, p. 65-79 -- 8. Clarifying the Vitamin D Controversy: The Health Benefits of Supplementation by Diet Versus Sunshine / Deon Wolpowitz and Barbara Gilchrest, p. 81-102 -- 9. Modern Photoprotection of Human Skin / Jean Krutmann and Daniel Yarosh, p. 103-112 -- 10. Vitamins and Polyphenols in Systemic Photoprotection / Wilhelm Stahl, Hasan Mukhtar, Farrukh Afaq and Helmut Sies, p. 113-121 -- 11. Hormone Replacement Therapy and Skin Aging / Glenda Hall and Tania Phillips, p. 123-132 -- 12. Skin Aging in Three Dimensions / Niels Krejci-Papa and Robert Langdon, p. 133-142 -- 13. Retinoid Therapy for Photoaging / Laure Rittié, Gary Fisher and John Voorhees, p. 143-156 -- 14. Topical Photodynamic Therapy / Dany Touma and Rolf-Markus Szeimies, p. 157-166 -- 15. Botulinum Toxin, Fillers, Peels: The Scientific View / Nanna Schürer, p. 167-184 -- 16. Lasers / Roland Kaufmann and Christian Beier, p. 185-194.
    Also available: Print – 2006
  • 2016From: Karger
    volume editor, Tove Agner.
    Filaggrin and skin barrier function -- Stratum Corneum lipids: their role for the skin barrier function in healthy subjects and atopic dermatitis patients -- Importance of tight junctions in relation to skin barrier function -- Antimicrobial peptides, infections and the skin barrier -- Biological variation in skin barrier function: from A (atopic dermatitis) to X (xerosis) -- Methods for the assessment of barrier function -- In vivo raman confocal spectroscopy in the investigation of the skin barrier -- Irritants and skin barrier function -- Skin barrier function and allergens -- Penetration through the skin barrier -- Treatments improving skin barrier function -- Standards for the protection of skin barrier function -- The role of the skin barrier in occupational skin diseases -- Wet work and barrier function -- Saving the barrier by prevention.
  • 2013From: CRCnetBASE
    edited by Toyoko Imae.
    1. Structure and functionality of the skin / Ichiro Hatta -- 2. Response for external stimulation on the skin / Masaki Ujihara and Toyoko Imae -- 3. Beautification of the skin / Satoshi Amano, Tomonobu Ezure, and Toshii Iida -- 4. Skin bioscience : a molecular approach / Yoshimitsu Kuroyanagi.
  • 2014From: Springer
    Alfonso Baldi, Paola Pasquali, Enrico Spugnini editors.
    Skin Cancer: A Practical Approach presents a comprehensive and up to date overview on skin cancer. With an emphasis on practical aspects that will set the basis for guidelines of treatment, the volume presents different diagnostic tools to help physicians obtain the proper diagnosis. Written by a worldwide base of experts selected on their recognized expertise on the different themes discussed, Skin Cancer: A Practical Approach is a valuable resource for investigators in the field of skin cancer, including pathologists, medical and surgical oncologists, dermatologists, general surgeons, and veterinary oncologists.
  • 2011From: Springer
    Reinhard Dummer ... [et al.], (editors).
    The dramatic increase in the incidence of skin cancers is a major concern worldwide and relates not only to melanoma but also to other cancers, including Merkel cell and basal cell carcinomas. Recently, the WHO has summarized the genetic and pathologic features of skin cancers in its book series. However, the WHO's proposed classification of certain disease entities, such as basal cell carcinomas, is still novel for many dermatologists. This book covers the entire spectrum of cutaneous malignancies in accordance with the new WHO classification. Epidemiology, pathogenesis, diagnosis, and therapy are all reviewed in detail, and care is taken to link the diagnostic and genetic features to optimized therapeutic strategies.-- Provided by publisher.
  • [edited by] Robert A. Schwartz.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009From: Springer
    edited by Eggert Stockfleth ... [et al.].
    Also available: Print – 2009
  • 2010From: Springer
    Deborah F. MacFarlane, editor.
    Biopsy techniques and interpretation / Deborah F. MacFarlane and Ronald P. Rapini -- Topical therapies for nonmelanoma skin cancers / Abel Torres and Tejas Desai -- Chemical peels for precancerous skin lesions / Gary D. Monheit and Chad L. Prather -- Photodynamic therapy / Nathalie C. Zeitouni, Allan Oseroff, and David J. Najarian -- Intralesional and perilesional treatment of skin cancers / Christopher J. Arpey, Nicole M. Annest, Stephen B. Tucker, Ronald P. Rapini, and Deborah F. MacFarlane -- Electrodesiccation and curettage / Gloria F. Graham -- Cryosurgery / Gloria F. Graham -- Optimizing surgical outcomes / Thomas Stasko and Amy Ross -- Anesthesia / Susannah L. Collier and George J. Hruza -- Excision techniques, staples, and sutures / Mollie A. MacCormack -- Mohs surgery / Desiree Ratner and Jennifer L. MacGregor -- Cutaneous flaps / Tatyana Humphreys -- Techniques in skin grafting / Deborah F. MacFarlane -- Nail surgery and malignant tumors of the nail unit / Deborah F. MacFarlane and Richard K. Scher -- Practical management of melanoma / Mark F. Naylor -- Skin cancer in skin of color / Brooke A. Jackson -- Management of skin cancers in solid organ transplant recipients / John Carucci and Dariush Moussai -- Imaging of head and neck skin cancer / Komal Shah, Jane Onufer, and Deborah F. MacFarlane -- Radiation oncology in skin cancer treatment / Susan L. McGovern and Matthew T. Ballo -- When to refer out / Daniel M. Siegel, Laura T. Cepeda, and Deborah F. MacFarlane -- Chemoprevention of skin cancer / Fiona Zwald and David Lambert.
  • edited by Ulrik Ringborg ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2016From: Springer
    Barbara Fowble, Sue S. Yom, Florence Yuen, Sarah Arron, editors.
    Scope of the Problem -- Anatomy of the Skin and Pathophysiology of Radiation Dermatitis -- Types of Radiation-Related Skin Reactions -- Skin Care Products Used During Radiation Therapy -- Head and Neck Cancer -- Thoracic Cancers -- Breast Cancer -- Gastrointestinal Cancer -- Genitourinary Cancer -- Gynecologic Cancer -- Central Nervous System -- Pediatrics -- Sarcoma -- Skin Cancer -- Locally Advanced Cancers.
  • 2011From: ClinicalKey
    Thomas P. Habif, James L. Campbell, M. Shane Chapman, James G.H. Dinulos, Kathryn A. Zug.
    Also available: Print – 2011
  • 2014From: Springer
    John C. Hall, editor.
    As the number of surviving immune suppressed patients continues to rise, skin manifestations of patients have become increasingly important. AIDS patients, and renal, heart, liver, bone marrow, and lung transplant patients are now living longer and immunosuppressive drugs are being used more frequently. Diabetes is rising in the US and around the world, offering its own unique brand of immune suppressed skin diseases. The skin may be the earliest sign of these conditions and be the organ showing the most profound, earliest, and treatment limiting side effects. Skin Diseases in the Immunocompromised is the most comprehensive book on the topic available. It elucidates the signs of immune suppressed skin diseases to afford early diagnosis and management of this ever-increasing diverse group of illnesses. Organized for easy access, this book will be an essential resource for residents and fellows in dermatology and infectious diseases medical professionals.
  • 2006From: ScienceDirect
    edited by Piercarlo Sarzi-Puttini ... [et al.].
  • 2014From: Springer
    Marco Matucci-Cerinic, Daniel Furst, David Fiorentino, editors.
    Rheumatologic diseases are highly associated with clinical symptoms of the skin, nails, and mucosal membranes. This book provides the practicing rheumatologist with a rapid, easy to consult reference to help interpret the nature of these cutaneous lesions and then quickly decide upon the appropriate follow-up tests. Utilizing an abundance of informative photographs, it contains all of the essential information needed for early diagnosis and treatment. This comprehensive guide properly orients the practitioner within the challenging world of rheumatologic disorders of the skin and gives insight into when consultation with a dermatologist is advisable.
  • 2015From: Springer
    Miranda A. Farage, Kenneth W. Miller, Nancy Fugate Woods, Howard I. Maibach, editors.
    An era of global population aging is upon us. By 2030, one in eight people will be over age 65. Since women generally live longer than men, the health and welfare of postmenopausal women will become a significant public health concern. This book offers a comprehensive review of the life changes associated with menopause, both at the dermatological and physiological level (e.g., hormonal, immunological) and at the subcellular level. It critically examines the dermatological, biological, and clinical challenges to postmenopausal health and well-being and the current and emerging therapeutic interventions. The authors advocate a holistic approach, emphasizing the need to view the menopause as a life transition with various facets rather than as a series of distinct medical conditions to be managed. Our goal is to offer a comprehensive resource to the researchers, clinicians, physicians, and helping professions whose mission is to promote the health and well-being of women around the world.
  • 2015From: Springer
    Luc Teot, Sylvie Meaume, Sadanori Akita, William J. Ennis, Veronique Del Marmol, editors.
    In recent years, wound care has gained increasing recognition as a distinct medical specialty. An understanding of the complex mechanisms involved in wound healing facilitates efficient assessment and treatment of patients with wounds, and skin necrosis can be considered the starting point in the entire healing process. This book is the first to discuss skin necrosis as a symptom related to a broad range of pathologies. Richly illustrated, it primarily provides therapeutic strategies and treatment algorithms for different clinical contexts. All chapters were written by renowned specialists in their respected fields and include detailed sample cases and essential take-home messages. In light of the highly interdisciplinary nature of wound management, Skin Necrosis offers an invaluable resource for wound care practitioners and health care professionals across the fields of surgery, dermatology, internal medicine, and nursing.
  • 2013From: Springer
    Andrew F. Alexis, Victoria H. Barbosa, editors ; foreword by A. Paul Kelly.
    This book serves as a practical guide to the diagnosis and treatment of common skin disorders in patients with skin of color. Emphasizing practical insights into diagnosis and treatment of skin and hair disorders in darker skinned patient populations, Skin of Color offers a detailed discussion of the nuances of treating skin of color. Topics of discussion include: management of acne, keloids, melasma, postinflammatory hyperpigmentation, acne keloidalis nuchae, alopecias, and the safe and effective use of chemical peels, laser procedures, and injectable fillers and toxins in skin of color patients.
  • 2007From: Karger
    volume editors, S. Schliemann, P. Elsner.
    Also available: Print – 2007
  • 2008From: WHO
    Also available: Print – 2008
  • 2013From: Springer Protocols
    edited by Kursad Turksen.
    Interfollicular epidermal stem cells : boosting and rescuing from adult skin / Mariana T. Cerqueira, Ana M. Frias, Rui L. Reis and Alexandra P. Marques -- Isolation and cultivation of human scalp interfollicular epidermal stem cells / Longmei Zhao and Basil M. Hantash -- Isolation of hair follicle bulge stem cells from YFP-expressing reporter mice / Kerry-Ann Nakrieko, Timothy S. Irvine, and Lina Dagnino -- Analysis of bulge stem cells from the epidermis using flow cytometry / Rehan M. Villani, Mehmet Deniz Akyuz, Michaela T. Niessen and Carien M. Niessen -- Lineage tracing of hair follicle stem cells in epidermal whole mounts / Monika Petersson, Daniela Frances, and Catherin Niemann -- Isolation and characterization of cutaneous epithelial stem cells / Uffe B. Jensen, Soosan Ghazizadeh, and David M. Owens -- Identification and analysis of epidermal stem cells from primary mouse keratinocytes / Youliang Wang and Xiao Yang -- Monitoring the cycling activity of cultured human keratinocytes using a CFSE-based dye tracking approach / Loubna Chadli, Emmanuelle Cadio, Pierre Vaigot, Michèle T. Martin and Nicolas O. Fortunel -- Quantification of cyclobutane pyrimidine dimers in human epidermal stem cells / M. Ruetze, S. Gallinat, H. Wenck and A. Knott -- Analysis of gene expression in skin using laser capture microdissection / Briana Lee, Mikhail Geyfman, Bogi Andersen and Xing Dai -- Qualitatively monitoring binding and expression of the transcription factor Sp1 as a useful tool to evaluate the reliability of primary cultured epithelial stem cells in tissue reconstruction / Manon Gaudreault, Danielle Larouche, Lucie Germain, and Sylvain L. Guérin -- Genetic manipulation of keratinocyte stem cells with lentiviral vectors / Masahito Yasuda, David J. Clayppl, Erika Guevara, Dennis R. Roop and Jiang Chen -- Using 3D culture to investigate the role of mechanical signaling in keratinocyte stem cells / Lee Wallace and Julia Reichelt -- In vivo transplantation assay at limiting dilution to identify the intrinsic tissue reconstitutive capacity of keratinocyte stem cells and their progeny / Holger Schlüter and Pritinder Kaur -- Melanoblasts as multipotent cells in murine skin / Tsutomu Motohashi and Takahiro Kunisada -- Generation of human melanocytes from induced pluripotent stem cells / Shigeki Ohta, Yoichi Imaizumi, Wado Akamatsu, Hideyuki Okano and Yutaka Kawakami -- Cellular populations isolated from newborn mouse skin including mesenchymal stem cells / Lauren Kimlin and Victoria Virador -- Isolation, characterization, and differentiation of human multipotent dermal stem cells / Ling Li, Mizuho Fukunaga-Kalabis, and Meenhard Herlyn -- Isolation and differentiation of hair follicle-derived dermal precursors / Andrew Hagner and Jeff Biernaskie -- Isolation of mesenchymal stem cells from human dermis / Tsutomu Soma, Jiro Kishimoto, and David Fisher -- Skin-derived mesenchymal stem cells : isolation, culture, and characterization / M. Orciani and R. Di Primio -- Isolation and establishment of hair follicle dermal papilla cell cultures / Karl Gledhill, Aaron Gardner, and Colin A.B. Jahoda -- Enrichment of oral mucosa and skin keratinocyte progenitor/stem cells / Kenji Izumi, Cynthia L. Marcelo, and Stephen E. Feinberg -- Skin stem cells / Keita Inoue and Kotaro Yoshimura.
  • 2005From: ScienceDirect
    volume editor, Mark P. Mattson.
    Also available: Print – 2005
  • 2011From: Springer
    edited by Axel Hutt.
    Sleep and anesthesia resemble in many ways at a first glance. The most prominent common feature of course is the loss of consciousness, i.e. the loss of awareness of external stimuli. However a closer look at the loss of consciousness reveals already a difference between sleep and anesthesia: anesthesia is induced by an anesthetic drug whereas we may fall asleep without external cause. Other questions may arise about the difference of the two effects: do we dream during surgery under anesthesia, do we feel pain during sleep? Essentially, we may ask: what is common and what are the differences.
  • edited by Carole L. Marcus ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014From: Cambridge
    Professor Gregory Stores, MD, MA, FRCPsych, FRCP, Emeritus Professor of Developmental Neuropsychiatry, Department of Psychiatry, University of Oxford, Oxford, UK.
    1. General outline of sleep and its disorders in children and adolescents -- 2. Special considerations regarding sleep disturbance in children with a neurodevelopmental disorder -- 3. Main comorbid conditions in neurodevelopmental disorders capable of contributing to sleep disturbance -- 4. Sleep disturbance in specific neurodevelopmental disorders.
  • 2017From: ScienceDirect
    edited by Mitchell G. Miglis.
    Anatomy and physiology of normal sleep / L. Schneider -- Anatomy and physiology of the circadian system / R.P. Najjar, J.M. Zeitzer -- The functions of sleep and the effects of sleep deprivation / E.H. During, M. Kawai -- Sleep and cognitive impairment / B.R. Peters, S.J. Sha, K. Yaffe -- Sleep and movement disorders / L. Ashbrook, E.H. During -- Sleep and stroke / G.J. Meskill, C. Guilleminault -- Sleep and epilepsy / B. Razavi, R.S. Fisher -- Central nervous system hypersomnias / J. Cheung, C.M. Ruoff, E. Mignot -- Sleep and multiple sclerosis / D.J. Kimbrough, T.J. Braley -- Sleep and neuromuscular disease / S. Sakamuri, J.W. Day -- Sleep and headache / M. O'Hare, R.P. Cowan -- Sleep and the autonomic nervous system / M.G. Miglis.
  • 2008From: Springer
    edited by Joris C. Verster, S.R. Pandi-Perumal, David L. Streiner.
  • 2006From: Springer
    [edited by] Malcolm Lader, Daniel P. Cardinali, S.R. Pandi-Perumal.
    GABA[subscript A] receptor subtypes in sedation and hypnosis / Esa R. Korpi -- Sleep hippocampal theta rhythm and sensory processing / Marisa Pedemonte and Ricardo A. Velluti -- Monoaminergic mechanisms in the regulation of sleep-wakefulness: special emphasis on preoptic noradrenergic system / Vijay Ramesh and Velayudhan Mohan Kumar -- REM sleep function and brain monoamine regulation: an application of the search activity concept / Vadim S. Rotenberg -- Role of wakefulness area in the brainstem reticular formation in regulating rapid eye movement sleep / Birendra N. Mallick ... [et al.] -- The mechanistic relationship between NREM sleep and anesthesia / Laura E. Nelson, Nicholas P. Franks, and Mervyn Maze -- Time-dependent psychotropic drug effects: hints of pharmacochronomics, broader than circadian time structures / Haruo Nagayama ... [et al.] -- Melatonin interaction with BZ-Gaba[subscript A] receptors: implications for sleep induction / Lennard P. Niles -- Melatonin: a chronobiotic that not only shifts rhythms / Dieter Kunz and Richard Mahlberg -- Melatonin and human sleep / Irina V. Zhdanova -- Melatonin efficacy to treat circadian alterations of sleep in Alzheimer's disease / Daniel P. Cardinali ... [et al.] -- Pharmacotherapy for seasonal affective disorder / Timo Partonen -- Use and discontinuation of hypnosedative medications / Mirko Petrovic -- Long-term use of sleeping pills in chronic insomnia / Milton Kramer -- Risks of chronic hypnotic use / Daniel F. Kripke -- Effects of psychotropics on driving performance / Henry J. Moller, Colin M. Shapiro, and Leonid Kayumov -- Diagnosis, pathophysiology and treatment of hypersomnias / Sebastiaan Overeem and Michel Billiard -- Chronic disease and sleep architecture pharmacotherapeutic considerations / James J. Herdegen -- Benzodiazepines for sedation in infants and children / Eugene Ng and Vibhuti Shah -- The pharmacological management of fatigue and sleepiness in affective disorders / Karl Doghramji -- Next-day residual effects of sleeping medications on driving ability: a review of the literature / Joris C. Verster, Marinus N. Verbaten, and Edmund R. Volkerts -- Sleep and pain / Wilfred R. Pigeon, Hyung Park, and Michael J. Sateia -- Head injuries and sleep / Chanth Seyone and Babita Kara -- Psychopharmacological management of restless legs syndrome and periodic limb movements in sleep / Raed Hawa ... [et al.] -- A comparison of visual analog scale and categorical ratings in assessing the patient's estimate of sleep quality / Nava Zisapel, Ricardo Tarrasch, and Moshe Laudon -- The pharmacostrategy of treating sleep disorders in Parkinsonism / Jean-Jacques Askenasy -- The neuropharmacology of nightmares / J.F. Pagel -- The night eating syndrome / Grethe Seta Birketvedt and Jon R. Florholmen -- Drug effects on dreaming / Mehmet Yucel Agargun and Hanefi Ozbek -- Sleep problems in primary care / Alan G. Wade -- SSRIs and sleep in man / Sue J. Wilson and David J. Nutt -- Sleep and antipsychotic drugs in schizophrenia patients / Jaime M. Monti and Daniel Monti -- Sleep and epilepsy: from interrelationships to influence of antiepileptic drugs / Antonio Martins da Silva ... [et all.] -- Herbal medicines and sleep / Marcello Spinella.
  • 2006From: Karger
    volume editors, Winfried J. Randerath, Bernd M. Sanner, Virend K. Somers.
    Electrical stimulation of the upper airways muscles / Randerath, W.J. -- Cardiac pacemaker therapy in sleep apnea / Schichtl, T., Pfeifer, M. -- Surgical treatment for obstructive sleep apnea / Boudewyns, A.N., Van de Heyning, P.H. -- Alternative therapies for obstructive sleep apnea syndrome : behavioral and pharmacological options / Smith, I.E. -- Central sleep apnea, hypoventilation syndromes, and periodic breathing disorders / Caples, S.M., Somers, V.K. -- Cardiovascular complications of sleep-related breathing disorders / Naughton, M.T., Sanner, B.M. -- Sleep-related breathing disorders in children / Amin, R.S. ... [et al.] -- Sleep-related breathing disorders in the elderly / Cooke, J.R., Ancoli-Israel, S. -- Sleep-disordered breathing in pregnancy / Sullivan, C.E., Edwards, N. Obstructive sleep apnea-hypopnea syndrome definitions of pathophysiology / De Backer, W. -- Oxidative stress--the culprit of obstructive sleep apnea syndrome / Lavie, L., Lavie, P. -- Genetics aspects of the obstructive sleep apnea/hypopnea syndrome / Riha, R.L. -- Upper airway muscles in obstructive respiratory sleep disorders / Svanborg, E. -- Obstructive sleep apnea : clinical presentation, diagnosis, and treatment / Yim, S., Jordan, A., Malhotra, A. -- Automatic positive airway pressure titration and treatment / Randerath, W.J. -- Treatment humidification in sleep-related breathing disorders / Benjafield, A.V., Richards, G.N. -- Oral appliances in the treatment of obstructive sleep apnea and snoring / Marklund, M. Sleep disorders and their classification--an overview / Lévy, P., Viot-Blanc, V., Pépin, J.-L -- Physiology of sleep and dreaming / Penzel, T., Kesper, K. -- Physiology of breathing during sleep / Schäfer, T. -- Physiology of the cardiovascular, endocrine, and renal systems during sleep / Peter, J.G., Fietze, I. -- History and questionnaires / Rühle K.-H. -- Objectifying sleepiness / Hein, H. -- Portable monitoring systems / Hein, H. -- Polysomnography / Penzel, T. -- Nasal, lung, and cardiovascular function tests / Galetke, W. -- Upper airway imaging in sleep apnea syndrome / Pinto Basto, R., Rodenstein, D.O. -- Upper airway obstruction in snoring and upper airway resistance syndrome / Kirkness, J.P. ... [et al.].
    Also available: Print – 2006
  • edited by T. Douglas Bradley, John S. Floras.
    PrintStatus: Not Checked OutLane Catalog Record
    Diurnal molecular rhythms : unrecognized critical determinants of cardiovascular health and disease / Michael J. Sole and Tami A. Martino -- Lower brainstem mechanisms of cardiorespiratory integration / Patrice G. Guyenet -- Mechanical interactions between the respiratory and circulatory systems / Sheldon Magder -- Respiratory and cardiac activity during sleep onset / John Trinder and Christian L. Nicholas -- Physiological effects of sleep on the cardiovascular system / Richard L. Horner -- Sleep apnea and alterations in glucose metabolism / Naresh M. Punjabi -- Oxidative stress, inflammation, and vascular function in obstructive sleep apnea syndrome / John Garvey ... [et al.] -- Obesity, sleep apnea, and the cardiorespiratory effects of leptin / Kenneth R. McGaffin and Christopher P. O'Donnell -- Influence of sleep and sleep apnea on autonomic control of the cardiovascular system / Krzystof Narkiewicz -- Epidemiological evidence for an association between sleep apnea, hypertension and cardiovascular disease / Yamini S. Levitzky and Susan Redline -- Treatment of hypertension in sleep apnea / Oded Friedman and Alexander G. Logan -- Sleep apnea and cardiac arrhythmias / Richard S.T. Leung and Clodagh M. Ryan -- Obstructive sleep apnea and atherosclerosis / Geraldo Lorenzi-Filho and Luciano F. Drager -- Sleep apnea and stroke / Massimiliano M. Siccoli and Claudio L. Bassetti -- Circadian rhythm of cardiac and cerebrovascular ischemic events / Dan Sprajja and Apoor S. Gami -- Quantitative models of periodic breathing and Cheyne-Stokes respiration / Michael C.K. Khoo -- Pathophysiological interactions between sleep apnea and heart failure / Dai Yamino, John S. Floras, and T. Douglas Bradley -- Prevalence and prognostic significance of obstructive and central sleep apnea in heart failure / Paula A. Lanfranchi -- Treatment of obstructive and central sleep apnea in patients with heart failure / Matthew T. Naughton and Michael Arzt.
  • 2009From: ClinicalKey
    [edited by] Michael Friedman.
    A multi-disciplinary approach that covers both the surgical and non-surgical interventions for sleep apnea and snoring. Full-color line drawings illustrate key concepts and create a comprehensive way of learning surgical techniques. Provides quick, easy access to the most up-to-date surgical and non surgical interventions for sleep apnea and snoring. Includes contributions from leaders in neurology, pulmonology, psychiatry, otolaryngology, and oral & maxillofacial surgery. Covers new and innovative procedures including ZPP (Zeta palatopharyngoplasty), Transpalatal Advancement Pharyngoplasty and Minimally invasive submucosal glossectomy. Details when and why surgery is necessary, and how to perform a successful operation for snoring and sleep apnea.
  • 2015From: CRCnetBASE
    edited by William Olds.
    Machine generated contents note: pt. I Introduction: The Watch Inside all of Us -- 1. Regulation of Prokineticin 2 Expression by Light and the Circadian Clock / Qun-Yong Zhou -- 2. Circadian Signatures in Rat Liver: From Gene Expression to Pathways / Ioannis P. Androulakis -- 3. Body Weight, Metabolism, and Clock Genes / Sandra M.F. Villares -- pt. II Metabolism at Night versus the Morning -- 4. Circadian Desynchrony Promotes Metabolic Disruption in a Mouse Model of Shiftwork / Henrik Oster -- 5. Circadian Rhythms and Obesity in Mammals / Oren Froy -- 6. Food and the Circadian Activity of the Hypothalamic-Pituitary-Adrenal Axis / A.C. Moreira -- 7. Circadian and Dark-Pulse Activation of Orexin/Hypocretin Neurons / Hugh D. Piggins -- 8. Meal Time Shift Disturbs Circadian Rhythmicity Along with Metabolic and Behavioral Alterations in Mice / Sehyung Cho -- 9.A Metabolic--Transcriptional Network Links Sleep and Cellular Energetics in the Brain / Jonathan P. Wisor -- pt. III Effects of Artificial Light and Sleep Disruption on Metabolism -- 10. Pathophysiology and Pathogenesis of Circadian Rhythm Sleep Disorders / Kazuo Mishima -- 11. Shift Work, Jet Lag, and Female Reproduction / Megan M. Mahoney -- 12.A New Approach to Understanding the Impact of Circadian Disruption on Human Health / John D. Bullough -- 13. Waking and Sleeping in the Rat Made Obese Through a High-Fat Hypercaloric Diet / Roberto Amici -- 14. Effect of Sleep Deprivation on Brain Metabolism of Depressed Patients / William E. Bunney, Jr.
  • 2014From: Springer
    Matt T. Bianchi, editor.
    The cognitive and behavioral implications of sleep deprivation have been noted in the medical literature for many years. In addition, emerging research continues to demonstrate the contribution of sleep deprivation to some of the most common and costly health conditions today. Sleep Deprivation and Disease provides clinically relevant scientific information to help clinicians, public health professionals, and researchers recognize the ramifications of sleep deprivation across a broad spectrum of health topics. This timely reference covers sleep physiology, experimental approaches to sleep deprivation and measurement of its consequences, as well as health and operational consequences of sleep deprivation. Clinical challenges and areas of uncertainty are also presented in order to encourage future advancements in sleep medicine and help patients avoid the outcomes associated with the myriad causes of sleep deprivation.
  • 2012From: Cambridge
    edited by Nancy Wesensten.
    Provides a critical review of stimulant medication literature regarding stimulant efficacy for restoring/maintaining cognition during sleep loss.
  • 2012From: Springer
    Leila Kheirandish-Gozal, David Gozal, editors.
    Part 1. The Normal Upper Airway -- Upper Airway Structure During Development / Seung Hoon Lee -- Functional Aspects and Upper Airway Control During Wakefulness and Sleep / Neriel Katz, Tamar Etzioni and Giora Pillar -- Lymphadenoid Tissues in the Upper Airway / Jinkwan Kim and David Gozal -- The Nasal Airway / Fuad M. Baroody -- Part 2. Sleep During Development -- Neural Mechanisms of Sleep and Circadian Rhythms / Edgar Garcia-Rill -- EEG and Sleep During Development / Raffaele Ferri, Luana Novelli and Oliviero Bruni -- Autonomic Cardiovascular Regulation During Sleep / Anna Vlahandonis, Lisa M. Walter, Stephanie R. Yiallourou and Rosemary S.C. Horne -- Arousal: Ontology, Functional Anatomy, Methodology, and Consequences / Eliot S. Katz -- Metabolic and Hormonal Regulation During Sleep / Riva Tauman -- Chemoreceptors, Breathing, and Sleep / John L. Carroll, Supriya K. Jambhekar and David F. Donnelly -- Pathophysiology of Pediatric Obstructive Sleep Apnea: Putting It All Together / Eliot S. Katz -- Part 3. Diagnostic Assessment of Sleep and Breathing in Children -- Clinical Evaluation of the Pediatric Patient / Hari P.R. Bandla -- Actigraphy / Hawley E. Montgomery-Downs and Lisa J. Meltzer -- Abbreviated/Portable Recordings / Luigi Ferini-Strambi -- Overnight Sleep Study and MSLT / Jyoti Krishna -- Upper Airway Imaging in Children with Obstructive Sleep Apnea Syndrome / Raanan Arens and Sanghun Sin -- The "Omics" Future: Genomics, Transcriptomics, and Proteomics / Sina A. Gharib -- Pediatric Sleep-Disordered Breathing: Criteria and Spectrum of Disease / Karen Spruyt -- Part 4. SDB in Children -- Apnea of Prematurity / Christian F. Poets -- Epidemiologic Aspects of Pediatric OSA Around the World / Athanasios Kaditis -- Obesity and Sleep / Edward O. Bixler, Alexandros N. Vgontzas, Marina Tsaoussoglou and Susan L. Calhoun -- Obstructive Sleep Apnea in Children with Down Syndrome / Dennis Rosen -- Children with Neuromuscular Disorders / Aviv D. Goldbart -- Sleep Problems in Children with Sickle Cell Disease / Umakanth Khatwa, Alia Bazzy-Asaad and Sanjeev V. Kothare -- Children with Craniofacial Syndromes / Wendy Estrellado-Cruz and Robert C. Beckerman -- Epilepsy, Headache, and Sleep-Disordered Breathing / Martina Vendrame and Sanjeev V. Kothare -- Sleep and Breathing in Cystic Fibrosis / Amanda J. Piper -- Asthma and Obstructive Sleep Apnea / Leila Kheirandish-Gozal -- Central Hypoventilation Syndromes / Iris A. Perez, Thomas G. Keens and Sally L. Davidson Ward -- Health-Care Utilization and Pediatric Obstructive Sleep Apnea / Ariel Tarasiuk and Haim Reuveni -- Gastroesophageal Reflux and Sleep-Disordered Breathing / Hari P.R. Bandla and Aparna R. Rao -- Part 5. Consequences of SDB in Children -- Behavioral Morbidity in Pediatric Sleep-Disordered Breathing / Elise K. Hodges, Barbara True Felt, Bruno J. Giordani and Ronald D. Chervin -- Neurocognitive Function and Learning in Children with Sleep-Disordered Breathing / Karen Spruyt -- Brain Regulatory Mechanisms Underlying Breathing: Insights for Sleep Pathology / Ronald M. Harper, Rajesh Kumar, Paul M. Macey, Jennifer A. Ogren and Mary A. Woo -- Cardiovascular Implications / Rakesh Bhattacharjee and Leila Kheirandish-Gozal -- Metabolic Consequences of Sleep Disorders / David Gozal -- Enuresis and Obstructive Sleep Apnea in Children / Oscar Sans Capdevila and Maria Eugenia Russi Delfraro -- Part 6. Treatment of SDB -- Adenotonsillectomy / Rakesh Bhattacharjee -- Corticosteroids and Leukotriene Modifiers in Pediatric SDB / Aviv D. Goldbart and Leila Kheirandish-Gozal -- CPAP Treatment in Children / Dafna Ofer and Carole L. Marcus -- Mandibular Advancement Devices / Maria Pia Villa and Silvia Miano -- Diaphragmatic Pacing in Infants and Children with Congenital Central Hypoventilation Syndrome / Anthony C. Chin, Donald B. Shaul, Pallavi P. Patwari, Thomas G. Keens and Anna S. Kenny, et al.
  • edited by Antonio Culebras.
    PrintStatus: Not Checked OutLane Catalog Record
    Concept of sleep medicine and of neurosomnology / Antonio Culebras -- Disorders of development and maturation of sleep / Stephen H. Sheldon -- Sleep disorders associated with mental retardation / Michael J. Rack -- Insomnia in neurology / Federica Provini, Carolina Lombardi, and Elio Lugaresi -- Delayed sleep phase disorder and other circadian rhythm sleep disorders / Baruch El-Ad -- Narcolepsy / Claudio L. Bassetti -- Secondary narcolepsy / Thomas E. Scammell -- Hypocretin, hypothalamic system / Christian R. Baumann and Claudio L. Bassetti -- Idiopathic hypersomnia and recurrent hypersomnia / Douglas B. Kirsch and Ronald D. Chervin -- Motor disorders of sleep: periodic, aperiodic, and rhythmic motor disorders / Roberto Vetrugno and Pasquale Montagna -- Restless legs syndrome / Renata Egatz, Belen Cabrero, and Diego Garcia-Borreguero -- Periodic leg movements of sleep / Diego Garcia-Borreguero, Oscar Larrosa, and Renata Egatz -- Sleep in Parkinson's disease / Robert L. Rodnitzky -- Epilepsy and sleep / Bradley V. Vaughn and O'Neill F. D'Cruz -- Somnambulism, somniloquy, and sleep terrors / Rosalia Silvestri -- Rapid eye movement sleep behavior disorder / Mark W. Mahowald and Carlos H. Schenck -- Obstructive and nonobstructive sleep apnea: the neurological perspective / Gulcin Benbir and Christian Guilleminault -- Sleep apnea and stroke / Antonio Culebras -- Sleep disturbances in dementia and other neurodegenerative -- disorders / Alon Y. Avidan -- Autonomic dysfunctions in sleep disorders / Pietro Cortelli and Carolina Lombardi -- Headache disorders and sleep / Antonio Culebras -- Sleep in traumatic brain injury and other acquired central nervous system conditions / Mark W. Mahowald -- Sleep disorders associated with multiple sclerosis / Antonio Culebras -- Sleep disorders and neuromuscular disorders / Antonio Culebras --Stimulant-dependent and hypnotic-dependent sleep disorders / Harold R. Smith.
  • 2006From: NAP
    Committee on Sleep Medicine and Research, Board on Health Sciences Policy ; Harvey R. Colten and Bruce M. Altevogt, editors.
    Sleep physiology -- Extent and health consequences of chronic sleep loss and sleep disorders -- Functional and economic impact of sleep loss and sleep-related disorders -- Improving awareness, diagnosis, and treatment of sleep disorders -- Ensuring adequate diagnosis and treatment : access, capacity, and technology development -- Opportunities to improve career development in somnology -- Bolstering somnology and sleep disorders research programs -- Building sleep programs in academic health centers.
  • 2013From: Springer
    edited by Hrayr P. Attarian, Mari Viola-Saltzman.
    In Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition, a multidisciplinary panel of eminent researchers and practicing clinicians comprehensively updates the multifaceted aspects of sleep disorders in women at different stages of life, illuminating the unique impact that each reproductive and endocrine stage has on both normal sleep and sleep disorders. This title not only introduces primary care physicians and health care providers to the discipline of sleep disorders in women, it also will appeal to a broader set of specialists as it summarizes the latest, cutting-edge research and presents it in a succinct and clinically relevant manner. The goal of this book is to help physicians recognize the symptom patterns of sleep disorders in their female patients, guide them in diagnosing and treating these patients in a timely fashion, and help in the elimination of gender bias in sleep medicine research and care. An invaluable addition to the literature, Sleep Disorders in Women: A Guide to Practical Management, 2nd Edition again fills an important niche by being an accessible, comprehensive, multidisciplinary review on sleep disorders in women.
  • [edited by] Sudhansu Chokroverty.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction / William C. Dement -- An overview of normal sleep / Sudhansu Chokroverty -- Sleep deprivation and sleepiness / Sudhansu Chokroverty -- Neurobiology of rapid eye movement and non-rapid eye movement sleep / Robert W. McCarley -- Neurophysiologic mechanisms of slow-wave (non-rapid eye movement) sleep / Mircea Steriade -- Neurotransmitters, neurochemistry, and the clinical pharmacology of sleep / Max Hirshkowitz, Mary Wilcox Rose and Amir Sharafkhaneh -- Physiologic changes in sleep / Sudhansu Chokroverty -- Circadian timing and sleep-wake regulation / Robert Y. Moore -- Sleep and memory consolidation / Matthew P. Walker and Robert Stickgold -- Dreaming in sleep-disordered patients / Rosalind Cartwright -- Polysomnographic technique : an overview / Sharon A. Keenan -- Electroencephalography, electromyography, and electro-oculography : general principles and basic technology / Thaddeus S. Walczak and Sudhansu Chokroverty -- Electrocardiographic technology of cardiac arrhythmias / Daniel M. Shindler and John B. Kostis -- Evaluation and monitoring of respiratory function / Reena Meara and Kingman P. Strohl -- Neuroimaging in sleep and sleep disorders / Martin Desseilles ... [et al.] -- Measurement of sleepiness and alertness : multiple sleep latency test / Thomas Roth and Timothy A. Roehrs -- The maintenance of wakefulness test / Karl Doghramji -- Clinical polysomnography and the evolution of recording and scoring technique / Max Hirshkowitz and Amir Sharafkhaneh -- Approach to the patient with sleep complaints / Sudhansu Chokroverty -- Classification of sleep disorders / Michael J. Thorpy -- Epidemiology of sleep disorders / Maurice Moyses Ohayon and Christian Guilleminault -- Human and animal genetics of sleep and sleep disorders / Stéphanie Maret, Yves Dauvilliers, and Mehdi Tafti -- Nutrition and sleep / Markku Partinen -- Obstructive sleep apnea syndrome / Christian Guilleminault and Michael Zupancic -- Positive airway pressure in the treatment of sleep apnea-hypopnea / Mark H. Sanders ... [et al.] -- Nature and treatment of insomnia / Charles M. Morin and Ruth M. Benca -- Narcolepsy / Christian Guilleminault and Vivien C. Abad -- Motor functions and dysfunctions of sleep / Wayne A. Hening ... [et al.] -- Sleep, breathing, and neurologic disorders / Sudhansu Chokroverty and Pasquale Montagna -- Sleep and epilepsy / Sudhansu Chokroverty and Pasquale Montagna -- Dreaming in neurologic disorders / Mark Solms and Susan Malcolm-Smith -- Sleep in psychiatric disorders / Peter L. Franzen and Daniel J. Buysse -- Sleep disturbances in general medical disorders / Sudhansu Chokroverty -- Circadian rhythm disorders / Mark W. Mahowald and Milton G. Ettinger -- Parasomnias / Jacques Montplaisir ... [et al.] -- Sleep disorders in the elderly / Sudhansu Chokroverty -- Sleep disorders of childhood / Richard Ferber -- Evolution of sleep from birth through adolescence, and sleep-disordered breathing in children / Timothy F. Hoban -- Women's sleep / Helen S. Driver and Eileen P. Sloan -- Sleep-related violence : forensic medicine issues / Mark W. Mahowald and Carlos H. Schenck.
  • pt. 1-2, 2011.From: ScienceDirect
    pt. 2, 2011From: ScienceDirect
    edited by Pasquale Montagna and Sudhansu Chokroverty.
  • edited by Carole L. Marcus ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012From: Springer
    Priyattam Shiromani...[et al.], editors.
    Circadian Clock Genes and the Regulation of Sleep / Thomas Curie and Paul Franken -- Clock Genes and Energy Metabolism / Hee-Kyung Hong, Wenyu Huang, Kathryn Moynihan Ramsey, Biliana Marcheva and Joseph Bass -- Neural Circuitry Responsible for Sleep and Wakefulness / Roda Rani Konadhode, Dheeraj Pelluru and Priyattam J. Shiromani -- Feeding as a Reward Mechanism / Ralph J. DiLeone, Nandakumar S. Narayanan and Douglas J. Guarnieri -- Plasticity of Brain Feeding Circuits in Response to Food / Tamas Horvath -- The Neurogenetics of Energy Balance / Martin G. Myers Jr. -- Short Sleep and Obesity Risk in Children / Chantelle N. Hart, Elizabeth S. Kuhl and Elissa Jelalian -- Circadian Misalignment and Sleep Disruption in Shift Work: Implications for Fatigue and Risk of Weight Gain and Obesity / Rachel R. Markwald and Kenneth P. Wright Jr. -- Sleep Apnea and Obesity / Vidya Krishnan and Sanjay R. Patel -- The Connection Between Sleep Loss, Obesity, and Type 2 Diabetes / Silvana Pannain, Guglielmo Beccuti and Eve Van Cauter -- Sleep Disturbances: Impact on Risk and Severity of Diabetes / Kelly A. Holes-Lewis -- Insufficient Sleep and Cardiovascular Disease / Susan Redline -- Clinical Guidelines for the Evaluation of Adults with Obstructive Sleep Apnea / Lawrence J. Epstein -- Pharmacological Treatment of Obesity / Dhiraj G. Kabra, Uma D. Kabra, Matthias H. Tschöp and Susanna Hofmann -- Bariatric Surgery for Treatment of Obesity / Mark J. Perna, Thomas Karl Byrne and Chitharanja C. Pullattrana.
  • 2015From: Springer
    Sudhansu Chokroverty, Michel Billiard, editors.
    Preface -- Acknowledgements -- Introduction -- I. Evolution of Sleep Medicine by Historical Periods -- Sleep in Ancient Egypt -- Sleep Medicine in the Arab Islamic Civilization -- Sleep Medicine in Ancient and Traditional India -- Sleep Medicine in Ancient and Traditional China -- Sleep in the Biblical Period -- Sleep in the New Testament -- The Greco-Roman Period -- The Aztec, Maya, and Inca Civilizations -- II. Sleep Medicine from the Medieval Period to the 19th Century -- Sleep Medicine in the Middle Ages and the Renaissance -- Sleep in the 17th and 18th Centuries -- III. The Early Evolution of Modern Sleep Medicine -- The Evolution of Sleep Medicine in the 19th and the Early 20th Century -- The History of Polysomnography: Tool of Scientific Discovery -- IV. Sleep Medicine Societies, Professional Societies, and Journals -- A History Behind the Development of Sleep Medicine and Sleep Societies -- Development of Sleep Medicine in Europe -- Evolution of Sleep Medicine in Japan -- History of Japanese Clinical Sleep Medicine -- Sleep Medicine around the World (Beyond North American and European Continents) -- V. Sleep Disorders in Historic Diseases -- Cholera -- Encephalities Lethargica -- African Sleeping Sickness -- Sleep and HIV Disease -- VI. Historical Milestones of Individual Sleep Disorders -- Evolution of the Classification of Sleep Disorders -- History of Epidemiological Research in Sleep Medicine -- The Insomnias: Historical Evolution -- VII. Neurological Sleep Disorders -- Narcolepsy ? Cataplexy Syndrome and Symptomatic Hypersomnia -- Idiopathic Hypersomnia -- Kleine-Levin Syndrome -- Movement Disorders in Sleep -- History of Restless Legs Syndrome, Recently Named Willis-Ekbom Disease -- Sleep and Stroke -- Sleep in Neurodegenerative Diseases -- Sleep, Cognitive Dysfunction, and Dementia -- Fatal Familial Insomnia and Agrypnia Excitata: Insights into Human Prion Disease Genetics and the Anatomo-Physiology of Wake and Sleep Behaviours -- Epilepsy and Sleep -- Sleep Disorders after Traumatic Brain Injury: Milestones in Perspective -- Headache Syndromes and Sleep -- VIII. Psychiatric and Psychological Sleep Disorders -- Depression -- Schizophrenia and Psychosis -- Bipolar Disorder -- IX. Respiratory Diseases -- A Short History of Obstructive Sleep Apnea Syndrome -- Upper Airway Resistance Syndrome: A Short History -- Restrictive and Obstructive Lung Diseases and Sleep Disorders -- NREM Arousal Parasomnias -- REM Sleep Behavior Disorder -- Chronobiology and Sleep -- X. Medical Disorders and Sleep -- Cardiovascular Disease and Sleep Dysfunction -- Nonrestorative Sleep, Musculoskeletal Pain, Fatigue in Rheumatic Disorders and Allied Syndromes: A Historical Perspective -- Sleep and Pain: Milestones and Advances from Research -- Endocrine-Metabolic Disorders and Sleep Medicine -- The Gut and Sleep -- Impotence and Erectile Problems in Sleep Medicine -- Women?s Health and Sleep Disorders -- XI. Miscellaneous Important Aspects -- The Emergence of Pediatric Sleep Medicine -- Sleep Disorders, Cognition, Accidents, and Performance -- Sleep Deprivation: Societal Impact and Long Term Consequences -- Sleep Models -- XII. Evolution of Treatment and Investigative Approaches in Sleep Medicine -- A History of Non-Pharmacological Treatments for Insomnia -- The Pharmacological Treatment of Sleep Disorders -- Psychological Treatment of Insomnia: The Evolution of Behavior Therapy and Cognitive Behavior Therapy -- Modafinil: Development and Use of the Compound -- Phylogeny in Sleep Medicine -- Gamma-Hyroxybutyrate (Sodium Oxybate): From the Initial Synthesis to the Treatment of Narcolepsy Cataplexy and Beyond -- Development and Impact of Brain Imaging Techniques.
  • 2014From: Wiley
    edited by Douglas B. Kirsch.
    A new addition to the Neurology in Practice series, Sleep Medicine in Neurology is a practical guide for neurologists diagnosing and managing sleep disorders in their patients. As a part of the series, various feature boxes are highlighted throughout. ""Tips and Tricks"" give suggestions on how to improve outcomes through practical technique or patient questioning. In addition, ""Caution"" warning boxes supply helpful advice on how to avoid problems and 'Science Revisited' boxes offer quick reminders of the basic science principles necessary for understanding the presented concepts.
  • 2015From: ClinicalKey
    Richard B. Berry, Mary H. Wagner.
  • 2015From: Springer
    Peter Meerlo, Ruth M. Benca, Ted Abel, editors.
    Behavioral and electrophysiological correlates of sleep and sleep homeostasis -- Genetic dissection of sleep homeostasis -- Sleep deprivation and gene expression -- Sleep and synaptic homeostasis -- Sleep and synaptic plasticity in the developing and adult brain -- Sleep and adult neurogenesis: implications for cognition and mood -- Animal studies on the role of sleep in memory: from behavioral performance to molecular mechanisms -- A bird's eye view of sleep-dependent memory consolidation -- Neuroimaging studies of sleep and memory in humans -- The role of sleep in human declarative memory consolidation -- Sleep-dependent memory consolidation in healthy aging and mild cognitive impairment -- Adenosine, caffeine, and performance: from cognitive neuroscience of sleep to sleep pharmacogenetics -- Optogenetic control of hypocretin (orexin) neurons and arousal circuits -- Stress, arousal, and sleep -- Sleep and emotional functions -- Sleep and plasticity in schizophrenia -- Chronically restricted or disrupted sleep as a casula factor in the development of depression -- Sleep deprivation therapy for depression -- Pharmacological treatment of sleep disorders and its relationship with neuroplasticity -- Index.
  • 2013From: Cambridge
    edited by Antonio Culebras.
    Overview of sleep and stroke / Antonio Culebras -- Sleep apnea, oxidative stress, proinflammatory vascular risk factors, and endothelial disease / Slava Berger, Lena Lavie -- Sleep apnea, autonomic dysfunction, and vascular diseases / Pietro Cortelli, Federica Provini -- Sleep apnea and hypertension : a clinical perspective / Nishida Barot, Clete A. Kushida -- Sleep apnea, stroke risk factors, and the arousal response / Mark Eric Dyken, George B. Richerson, Kyoung Bin Im -- Sleep apnea and atrial fibrillation / Apoor S. Gami -- Patent foramen ovale, obstructive sleep apnea, and its association with ischemic stroke / Alejandro M. Forteza -- Pathogenesis of cerebral small-vessel disease in obstructive sleep apnea / Gustavo C. Román -- Sleep apnea and acute stroke deterioration / Kristian Barlinn, Andrei V. Alexandrov -- Effect of continuous positive airway pressure on stroke risk factors and stroke / Malcolm Kohler, John R. Stradling -- Rehabilitation of stroke and sleep apnea / Behrouz Jafari, Vahid Mohsenin -- Restless legs syndrome, periodic limb movements in sleep, and vascular risk factors / Federica Provini -- Physician as patient / Harold R. Smith.
  • 2014From: Springer
    Sergio Garbarino, Lino Nobili, Giovanni Costa, editors.
    "Human Impact Assessment (HuIA) is a relatively new concept describing an integrated process that encompasses both Health Impact Assessment and Social Impact Assessment and is used to anticipate the effects of programs, projects and decisions on human health and welfare. Sleep occupies approximately one-third of our lives, but its human impact remains largely unrecognized. The prevalence of excessive sleepiness is recognized to be increasing in industrialized societies. Sleepiness and fatigue have high costs in terms of both lives lost and socioeconomic impact. Sleepiness and Human Impact Assessment provides a comprehensive exploration of many different facets of sleepiness in our 24-hour society from the new HuIA point of view. Among the covered issues are the physiology and pathophysiology of sleep, its relationship to daytime alertness, fatigue and drugs, the relevance of sleep-related fatigue in various occupational settings and public safety. This book will be of assistance to physicians, occupational health professionals, ergonomists, researchers and decision-makers as they strive to understand the full significance of sleepiness and to create a culture of accountability in everyday life without sleep-related risks."--Publisher's website.
  • 2015From: Springer
    Raman K. Malhotra, editor.
  • 2016From: ClinicalKey
    [edited by] Mark Feldman, Lawrence S. Friedman, Lawrence J. Brandt.
    V. 1: -- Sect. I: Biology of the gastrointestinal tract -- Sect. II: Nutrition in gastroenterology -- Sect. III: Symptoms, signs, and biopsychosocial issues -- Sect. IV: Topics involving multiple organs -- Sect. V: Esophagus -- Sect. VI: Stomach and duodenum -- Sect. VII: Pancreas -- Sect. VIII: Biliary tract -- V. 2: -- Sect. IX: Liver -- Sect. X: Small and large intestine -- Sect. XI: Additional treatments for patients with gastrointestinal and liver disease.
  • 2005From: Springer
    edited by Haruo Sugi.
    Also available: Print – 2005
  • 2014From: Springer
    Marcus-Matthias Gellrich ; with a contribution by Dieter Schmidt ; English translation by Carole Gustely Cürten.
    In this book the author describes in detail the history, construction, and examination potential of the slit lamp. In particular, however, he presents a new approach videography that allows the ophthalmologist to document all (!) eye diseases with the slit lamp and a video camera in a practicable, rapid, and affordable manner. The necessary methods, techniques, and equipment, including converging, diverging, and contact lenses, are clearly explained in the text and four didactic videos. The 20 most important videographic settings are described, and recipes for their use are presented, along with diagnostic tips. The accompanying collection of clinical images represents the world's first ever general atlas of ophthalmology from the perspective of the slit lamp. The author has already demonstrated proof of the value of ophthalmological videography in his own practice. It is his hope that this introductory book, with its many images never previously produced with a slit lamp, will stimulate others to exploit the approach's potential.
  • 2011From: ScienceDirect
    edited by Eus J. W. van Someren, Ysbrand D. Van Der Werf, Pieter R. Roelfsema, Huibert D. Mansvelder and Fernanado H. Lopes Da Silva.
    Slow oscillations in perspective and in detail -- Slow brain oscillations of sleep, resting, state, and vigilance -- Electrophysiological correlates of sleep homeostasis in freely behaving rats -- Involvement of cytokines in slow wave sleep -- Sleep and resting state EEG-profile as heritable endophenotype and during development -- Genetic determination of sleep EEG profiles in healthy humans -- Developmental aspects of sleep slow waves: linking sleep, brain maturation and behavior -- Phasic events during slow oscillations -- Phasic modulation of cortical high-frequency oscillations by pedunculopontine neurons -- Slow oscillations orchestrating fast oscillations and memory consolidation -- Spontaneous neural activity during human non-rapid eye movement sleep -- Thalamocortical and cortico-hippocampal network interactions during slow sleep oscillations -- Neuronal plasticity and thalamocortical sleep and waking oscillations -- Infraslow (<0.1 Hz) oscillations in thalamic relay nuclei: basic mechanisms and significance to health and diseaes states -- Hippocampal-cortical interactions and the dynamics of memory trace reactivation -- Cortica synchronization and travelling of slow oscillations -- Long-range correlation of the membrane potential in neocortical neurons during slow oscillation -- Temporal dynamics of cortical sources underlying spontaneous and peripherally evoked slow waves -- Functional beliefs of slow oscillations during sleep -- Sleep and developmental plasticity: not just for kids -- Evoked electrical and cerebral vascular responses during sleep and following sleep deprivation -- Reduction of nocturnal slow-wave activity affects daytime vigilance lapses and memory encoding but not reaction time or implicit learning -- Infraslow oscillations in resting state network activity during sleep and wakefulness -- Spectral characteristics of resting state networks -- Modulation of the brain's functional network architecture in the transition from wake to sleep -- Spontaneous fMRI activity during resting wakefulness and sleep -- Infraslow oscillations, consciousness and performance -- Hypnotic modulation of resting state mMRI default mode and extrinsic network connectivity -- Multimodal neuroimaging in patients with disorders of consciousness showing functional hemispherectomy -- Roles of multiscale brain activity fluctuations in shaping the variability and dynamics of psychophysical performance.
  • edited by Stanley B. Prusiner, William J. Hadlow.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Clinical, epidemiological, genetic, and pathological aspects of the spongiform encephalopathies -- v. 2. Pathogenesis, immunology, virology, and molecular biology of the spongiform encephalopathies.
  • 2006From: Springer
    edited by Peter ten Dijke and Carl-Henrik Heldin.
  • 2011From: Springer
    Fabian Kiessling, Bernd J. Pichler, editors. ; Peter Hauff, co-editor.
    Pt. I. Role of Small Animal Imaging -- 1. Noninvasive Imaging for Supporting Basic Research / Pat Zanzonico -- 2. Non-Invasive Imaging in the Pharmaceutical Industry / John C. Waterton -- 3. How to Set Up a Small Animal Imaging Unit / David Stout -- 4. Noninvasive Small Rodent Imaging: Significance for the 3R Principles / Peter Maier -- Pt. II. Study Planning and Animal Preparation -- 5. Institutional Preconditions for Small Animal Imaging / Rene H. Tolba -- 6. Statistical Considerations for Animal Imaging Studies / Hannes-Friedrich Ulbrich -- 7. Animal Anesthesia and Monitoring / Rene H. Tolba -- 8. Drug Administration / Peter Hauff -- Pt. III. Imaging Modalities and Probes -- 9. How to Choose the Right Imaging Modality / Peter Hauff -- 10. X-Ray and X-Ray-CT / Marek Karolczak -- 11. CT Contrast Agents / Hubertus Pietsch -- 12. Small Animal Magnetic Resonance Imaging: Basic Principles, Instrumentation and Practical Issue / Peter Jakob -- 13. MR Contrast Agents / Silvio Aime -- 14. MR Spectroscopy / Markus Becker -- 15. Ultrasound / Catherine Theodoropoulos -- 16. Ultrasound Contrast Agents / Michel Schneider -- 17. PET and SPECT / Sibylle I. Ziegler -- 18. Radiotracer I: Standard Tracer / Uwe Haberkorn -- 19. Radiotracer II: Peptide-Based Radiopharmaceuticals / Clemens Decristoforo -- 20.Optical Imaging / Vasilis Ntziachristos -- 21. Optical Probes / Kai Licha -- 22. Multi-modal Imaging and Image Fusion / Vesna Sossi -- Pt. IV. Ex Vivo Validation Methods -- 23. Ex Vivo and In Vitro Cross Calibration Methods / Thierry Delzescaux -- 24. In Vitro Methods for In Vivo Quantitation of PET and SPECT Imaging Probes: Autoradiography and Gamma Counting / David Stout -- pt. V Data Postprocessing -- 25. Qualitative and Quantitative Data Analysis / Volkmar Schulz -- 26. Guidelines for Nuclear Image Analysis / Bernd J. Pichler -- 27.Kinetic Modelling / Jorg van den Hoff -- 28.Data Documentation Systems / Wolfhard Semmler -- Pt. VI. Special Applications -- 29. Imaging in Developmental Biology / Michal Neeman -- 30. Imaging in Gynecology Research / Michael D. Menger -- 31. Imaging in Cardiovascular Research / Sven Hermann -- 32. Imaging in Neurology Research I: Neurooncology / Andreas H. Jacobs -- 33. Imaging in Neurology Research II: PET Imaging of CNS Disorders / Alexander Drzezga -- 34. Imaging in Neurology Research III: Focus on Imaging Neurotransmitter / Wynne K. Schiffer -- 35. Imaging in Oncology Research / Fabian Kiessling -- 36. Imaging in Immunology Research / Owen N. Witte.
  • 2007From: Springer
    [editors], Roberto Di Mizio, Mariano Scaglione.
  • Pratik Verma.
    Reductive activation of dioxygen by copper to generate potent oxidants for multi- electron organic transformations is exploited extensively in biological systems. This thesis focuses on two types of multi-electron oxidants: Cu2O2 complexes and copper complexes with redox-active ligands. The goal of this work is to identify the influence of nitrogen containing ancillary ligands on properties of dioxygen, semiquinone and phenoxyl radical complexes of copper. This work is aimed primarily at synthetic chemists interested in rational design of ligands for creating bio-inspired oxidants and oxidation catalysts. Chapter 1 of this thesis reports the identification of a Density Functional Theory (DFT) protocol for deriving structure-property relationships in Cu2O2 complexes. Chapter 2 of this thesis applies towards modeling electronic spectra, the DFT protocols that were validated in Chapter 1 for modeling thermodynamics. Chapter 3 of this thesis describes the properties and reactivity of Cu2O2 complex generated from a new hybrid permethylated-amine-guanidine ligand based on a 1,3- propanediamine backbone (2L). Chapter 4 of this thesis describes the characterization of an intermediate (C) that is observed in both phenol hydroxylation and catechol oxidation with the SP core supported by N1, N2-di-t-butylethane-1,2-diamine (DBED). Chapter 5 of this thesis describes the influence of sulfanyl substituents on the optical and redox properties of copper-bonded phenoxyls.
  • 2001From: NAP
    Charles H. Evans, Jr. and Suzanne T. Ildstad, editors ; Committee on Strategies for Small-Number-Participant Clinial Research Trials, Board on Health Sciences Policy, Institute of Medicine.
    Also available: Print – 2001
  • 2014From: Springer
    Brad Aiken.
    Like many fields of science, the future of medicine is frequently predicted by the science fiction writers of today, very much as many of today's medical advances were presaged by science fiction stories of the past. In this book, physician and science fiction author Brad Aiken conveys his own speculations about our medical future through nine highly entertaining and thought-provoking short stories. Touching upon a great variety of themes, including but not limited to telemedicine and remote surgery, vaccination strategies against unknown deathly pathogens, nanomedicine to cure diseases and retard ageing, bionics, cloning and euthanasia, we get a glimpse of what might be awaiting humanity. Yet, in these stories it is always the protagonists, humans after all, who remain at the center stage, not the new technologies. This provides the fictional material with a unique blend of science fiction and social fantasy. It also warns us to be wary of the pitfalls of too much reliance on dehumanizing technology and to make sure it remains our helper, not our master. Last but not least, an extensive scientific essay investigates the interplay between science fiction and both past and current advances in medical sciences and technology, making the link to the fictional material in the book as well as to the relevant scientific literature.
  • 2009From: Karger
    volume editors, Wieland Kiess, Steven D. Chernausek, Anita C.S. Hokken-Koelega.
    Children born small for gestational age : definitions and etiology / Wollmann, H.A. -- Diagnosis and management of in utero growth failure / Odibo, A.O.; Sadovsky, Y. -- Fetal growth restriction and the developmental origins of adult disease hypothesis : experimental studies and biological consequences / Krechowec, S.O.; Thompson, N.M.; Breier, B.H. -- Molecular genetic disorders of fetal growth / Chernausek, S.D. -- Birth weight and later risk of type 2 diabetes / Harder, T. ... [et al.] -- Low birth weight and optimal fetal development : a global perspective / Franko, K.L. ... [et. al.] -- Insulin-like growth factor/growth hormone axis in intrauterine growth and its role in intrauterine growth retardation / Kiess, W. ... [et al.] -- Clinical management of small-for-gestational-age babies / Knüpfer, M. -- Management of short stature in small-for-gestational-age children / Dahlgren, J. -- Puberty and adrenarche in small-for-gestational-age children / Hokken-Koelega, A.C.S. -- Neurological and intellectual consequences of being born small for gestational age / Tuvemo, T.; Lundgren, E.M. -- Low birth weight in developing countries / Qadir, M.; Bhutta, Z.A.
  • 2015From: Springer
    Ulrich Spandau, Zoran Tomic.
  • 2012From: Springer
    Herbert Blumberg, M. Valerie Kent, A. Paul Hare, Martin F. Davies.
  • pt. A-C, 1995.From: ScienceDirect
    pt. BFrom: ScienceDirect
    pt. CFrom: ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    pt. A. Ras family -- pt. B. Rho family -- pt. C. Proteins involved in transport.
    Also available: Print – pt. A-C, 1995.
  • pt. A-B, 2008.From: ScienceDirect
    pt. BFrom: ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – pt. A-B, 2008.
  • Sara Elaine Brownell.
    This thesis explores the use of small heat shock proteins as anti-inflammatory therapeutics in the context of neurological diseases, specifically multiple sclerosis (MS) and stroke. The family of small heat shock proteins (sHSPs) has been extensively studied as intracellular molecular chaperones. However, recent studies looking at the role of sHSPs in neurological diseases have demonstrated a near universal upregulation of certain sHSPs in damaged and diseased brains. Initially, it was thought that sHSPs are pathological in these disease states, but transgenic overexpression and exogenous administration of sHSPs in various experimental disease paradigms have shown just the contrary -- that sHSPs are protective, not pathological. In this thesis, I have found that members of the family of sHSPs are protective and therapeutic in mouse models of multiple sclerosis and stroke, experimental autoimmune encephalomyelitis (EAE) and middle cerebral artery occlusion (MCAO), respectively. Alpha B crystallin (cryab), a member of the sHSP family, is elevated in stroke and deficiency of cryab leads to worse disease outcome, illustrating the protective role of alpha B crystallin. Exogenous administration of small heat shock proteins, including alpha B crystallin, decreases disease severity by modulating the immune system. This leads to the conclusion that sHSPs are endogenous anti-inflammatory and neuroprotectant molecules produced after neurological disease, whose beneficial properties can be augmented when administered therapeutically.
  • 2013From: Springer
    Norberto Confalonieri, Sergio Romagnoli, editors.
    Minimally invasive joint replacement has become one of the hottest topics in the orthopedic world. In the case of the knee, however, this concept has been widely misunderstood. All too frequently it is taken to mean keyhole surgery in which traditional components are implanted with a shorter surgical time. Such an approach in fact has few benefits and various possible dangers. In this book, international experts discuss truly minimally invasive knee reconstruction techniques that involve tissue-sparing surgery and small implants and permit preservation of both the anterior and the posterior cruciate ligament. These techniques have the key advantage of respecting the physiological joint biomechanics. They also entail minimal removal of bone tissue from the tibia and only a small skin incision that avoids damage to the extensor apparatus. All of the most innovative techniques used in uni- and bicompartmental knee reconstruction are covered in detail, including computer-assisted procedures. Long-term results are reported, and pitfalls, highlighted. The reader will learn how, with careful selection of patients and rigorous surgical technique, compartmental reconstruction offers a valid alternative to total knee replacement.
  • 2015From: Springer
    Walter Sekundo, editor.
  • 2011From: Springer
    Lyubomir Vassilev, David Fry, editors.
    Hydrogen-bonded synthetic mimics of protein secondary structure as disruptors of protein-protein interactions / M.J. Adler, A.G. Jamieson and Andrew D. Hamilton -- Small-molecule inhibitors of IL-2/IL-2R : Lessons learned and applied / C.G. Wilson and M.R. Arkin -- Small molecule inhibitors of the human papillomavirus E1-E2 interaction / P.W. White, Anne-Marie Faucher and Nathalie Goudreau -- Design of small-molecule Smac mimetics as IAP antagonists / Shaomeng Wang -- Small-molecule inhibitors reveal a new function for Bcl-2 as a proangiogenic signaling molecule / Benjamin D. Zeitlin and Jacques E. Nör -- Small-molecule modulators of c-Myc/Max and Max/Max interactions / Thorsten Berg -- Small-molecule inhibitors of the p53-MDM2 interaction / Binh T. Vu and Lyubomir Vassilev.
  • 2010From: Springer Protocols
    edited by Mahesh Uttamchandani, Shao Q. Yao.
    The Expanding World of Small Molecule Microarrays / Mahesh Uttamchandani and Shao Q. Yao -- Construction of Photo-Cross-Linked Microarrays of Small Molecules / Naoki Kanoh -- Small Molecule Microarray : Functional-Group Specific Immobilization of Small Molecules / Hyang Yeon Lee and Seung Bum Park -- Detecting Protein-Small Molecule Interactions Using Fluorous Small Molecule Microarrays / Arturo J. Vegas and Angela N. Koehler -- A Method for Small Molecule Microarray-Based Screening for the Rapid Discovery of Affinity-Based Probes / Haibin Shi, Mahesh Uttamchandani, and Shao Q. Yao -- Nanodroplet Chemical Microarrays and Label-Free Assays / Dhaval Gosalia and Scott L. Diamond -- Nanodroplet Microarrays for High-Throughput Enzyme Screening / Kang L.D. Aw, Shao Q. Yao, and Mahesh Uttamchandani. The Application of the Chemical Array for Biological Study / Isao Miyazaki, Siro Simizu, and Hiroyuki Osada -- Peptide Arrays with a Chip / Alexander Nesterov, Edgar Dörsam, Yun-Chien Cheng, Christopher Schirwitz, Frieder Märkle, Felix Löffler, Kai König, Volker Stadler, Ralf Bischoff, and Frank Breitling -- In situ Chemical Modification of Peptide Microarrays : Characterization by Desorption/Ionization on Silicon Nanowires / Gaëlle Piret, Herv Drobecq, Carine Rouanet, Karim Chemlal, Anne-Sophie Debrie, Jean-Michel Hougardy, Françoise Mascart, Camille Locht, and Oleg Melnyk -- Peptide Microarrays on Coated Silicon Slides for Highly Sensitive Antibody Detection / Marina Cretich, Francesco Damin, Renato Longhi, Cecilia Gotti, Clelia Galati, Lucio Renna, and Marcella Chiari. Antibody Signatures Defined by High-Content Peptide Microarray Analysis / Antonia Masch, Johannes Zerweck, Ulf Reimer, Holger Wenschuh, and Mike Schutkowski -- High Density Peptide Microarrays for Proteome-Wide Fingerprinting of Kinase Activities in Cell Lysates / Alexandra Thiele, Matthias Weiwad, Johannes Zerweck, Gunter Fischer, and Mike Schutkowski -- A Peptide Microarray for Detecting Protein Kinase Activity in Cell Lysates / Xiaoming Han and Yoshiki Katayama -- Chemical Microarrays Constructed by Selective Attachment of Hydrazide-Conjugated Substances to Epoxide Surfaces and Their Applications / Sungjin Park, Myung-Ryul Lee, and Injae Shin -- A Microarray-Based Method to Perform Nucleic Acid Selections / Olga Aminova and Matthew D. Disney.
  • 2010From: Springer
    Uwe M. Martens (ed.).
    Protein kinase inhibitors -- Imatinib mesylate -- Erlotinib -- Axitinib -- Lapatinib -- Sorafenib -- Sunitinib -- Dasatinib -- Nilotinib -- Bosutinib -- Epigenetic modifiers -- Decitabine -- 5-Azacytidine/Azacitidine -- Cell cycle inhibitors -- Bortezomib -- Temsirolimus -- Danusertib (formerly PHA-739358): a novel combined pan-aurora kinases and third generation Bcr-Abl tyrosine kinase inhibitor -- BI_2536: targeting the mitotic kinase polo-like kinase 1 (Plk1) -- Other novel agents -- Imetelstat (GRN163L): Telomerase-based cancer therapy -- GDC-0449: targeting the hedgehog signaling pathway.
  • 2014From: Springer
    Uwe M. Martens, editor.
    Extensive research into the molecular mechanisms of cancer has heralded a new age of targeted therapy. The field of personalized cancer therapy is now growing rapidly, and the progress being made will result in significant changes in the treatment algorithms for cancer patients. Numerous novel targets that are crucial for the survival of cancer cells can be attacked by small molecules such as protein tyrosine kinase inhibitors. This book, written by acknowledged experts, discusses in detail the most recent developments in targeted cancer therapy using small molecules. A wide range of small molecules is covered, including, in addition to tyrosine kinase inhibitors, mTOR, proteasome, and multikinase inhibitors, among others. For each molecule, aspects such as chemical structure, mechanism of action, drug targets, drug interactions, preclinical studies, clinical trials, treatment applications, and toxicity are discussed.
  • 2015From: Springer Protocols
    edited by Mathieu Rederstorff.
    Small non-coding RNAs : a quick look in the rearview mirror / Guillaume Clerget, Yoann Abel, and Mathieu Rederstorff -- Alcoholic precipitation of small non-coding RNAs / Guillaume Clerget, Valérie Bourguignon-Igel, and Mathieu Rederstorff -- Quantification and quality control of a small non-coding RNA preparation / Virginie Marchand and Christiane Branlant -- Impact of RNA isolation protocols on RNA detection by Northern blotting / Katrin Damm [and seven others] -- Improved Northern blot detection of small RNAs using EDC crosslinking and DNA/LNA probes / Katrin Damm [and seven others] -- Direct cloning of double-stranded RNAs / Manli Shen [and three others] -- Detection and labeling of small non-coding RNAs by splinted ligation / Gabrielle Bourgeois [and three others] -- Fluorescence in situ hybridization of small non-coding RNAs / Valentin Vautrot [and three others] -- RT-qPCR-based quantification of small non-coding RNAs / Fjoralba Zeka, Pieter Mestdagh, and Jo Vandesompele -- Stem-loop RT-PCR based quantification of small non-coding RNAs / Véronique Salone and Mathieu Rederstorff -- miR-RACE : an effective approach to accurately determine the sequence of computationally identified miRNAs / Chen Wang and Jinggui Fang -- Probing small non-coding RNAs structures / Jean-Vincent Philippe [and three others] -- cDNA library generation for the analysis of small RNAs by high-throughput sequencing / Jennifer Gebetsberger, Roger Fricker, and Norbert Polacek -- CLIP-Seq to discover transcriptome-wide imprinting of RNA binding proteins in living cells / Jérôme Saulière and Hervé Le Hir -- Microarray analysis of small non-coding RNAs / Michael Karbiener and Marcel Scheideler -- RML-RACE, PPM-RACE, and qRT-PCR : an integrated strategy to accurately validate miRNA target genes / Chen Wang and Jinggui Fang -- Dual luciferase gene reporter assays to study miRNA function / Thomas Clément, Véronique Salone, and Mathieu Rederstorff -- Gene expression knockdown by transfection of siRNAs into mammalian cells / Yoann Abel and Mathieu Rederstorff -- Efficient and selective knockdown of small non-coding RNAs / Xue-Hai Liang, Wen Shen, and Stanley T. Crooke -- Cell-SELEX : in vitro selection of synthetic small specific ligands / Helena Dickinson [and three others] -- Small non-coding RNAs and aptamers in diagnostics and therapeutics / Marissa Leonard, Yijuan Zhang, and Xiaoting Zhang.
  • 2006From: Springer
    Wolfgang Nellen, Christian Hammann (eds.).
  • 2012From: Springer
    Thomas Liehr ; with contributions by Unique (the rare chromosome disorder support group).
    Introduction -- Inheritance of small supernumerary marker chromosomes -- Formation of small supernumerary marker chromosomes -- Small supernumerary marker chromosomes in genetic diagnostics and counseling -- Small supernumerary marker chromosomes known to be correlated with specific syndromes -- Centric small supernumerary marker chromosomes -- Neocentric small supernumerary marker chromosomes by chromosome -- Multiple small supernumerary marker chromosomes -- Small supernumerary marker chromosomes additionally to other chromosomal rearrangements -- Complex small supernumerary marker chromosomes -- Small supernumerary marker chromosomes and tumors -- Appendix: Patient organizations in connection with small supernumerary marker chromosomes -- Glossary.
  • 2013From: ProQuest Ebook Central
    S.L. Kotar and J.E. Gessler.
    "Scientifically known as Variola major, the deadliest form of smallpox has plagued mankind since 'time immemorial.' This text chronicles the worldwide effects of the killer disease, with particular emphasis on the 19th and 20th centuries, including the devastations of the "speckled disease" during great armed conflicts"--Provided by publisher.
  • 2013From: Thieme eNeurosurgery
    Michael J Lee, Daniel C. Norvell, Joseph R. Dettori, Andrea C. Skelly, Jens R. Chapman.
    "Planning, conducting, and publishing the results of your clinical research can be a long and arduous journey. The SMART Approach to Spine Clinical Research presents and explains the many interrelated components essential to spine clinical research in an easily accessible way, guiding you step-by-step through the principles and methods of planning and evaluating clinical research."--Cover.
  • 2007From: CRCnetBASE
    edited by George K. Knopf, Amarjeet S. Bassi.
  • 2013Limited to 1 simultaneous usersFrom: ProQuest Ebook Central
    Art Sobczak.
    The smart calling concept. Cold calling is dumb, but prospecting is necessary : smart calling is the answer -- Pre-call planning. Creating your possible value proposition ; Intelligence gathering : making your calls smart -- Using social engineering to gather intelligence ; Setting smart call objectives and never being rejected again ; More smart ideas for prior to your call -- Creating and placing the smart call. How to be smart with voice mail ; Working with screeners, gatekeepers, and assistants? ; Opening statements : what to avoid to minimize resistance ; Creating interest with your smart call opening statement ; Handling early resistance on your smart calls ; Using smart questions ; The more important side of the question : listening ; Recommending the next step ; Getting commitment for the next action ; Wrapping up calls and setting up the next action -- Putting it all together. How to sound smart : effective telephone communication ; Getting and staying motivated ; More smart calling success tips ; A smart call case study and makeovers.
  • 2008From: CRCnetBASE
    edited by Igor Galaev, Bo Mattiasson.
  • 2013 (18th ed.)From: AccessSurgery
    Lue, Tom F.; McAninch, Jack W.; Smith, Donald R.; Tanagho, Emil A.
    Also available: Print – <2013>
  • 2013From: ClinicalKey
    [edited by] Alan R. Aitkenhead, Iain K. Moppett, Jonathan P. Thompson.
    A practical guide for anaesthetists and other health care professionals involved in the perioperative period. This sixth edition has been thoroughly updated and reorganised to reflect current anaesthetic practice and the basic sciences that directly underpin it. The inclusion of several new chapters continues to ensure complete coverage of key and evolving areas and new, experienced authors also add a fresh perspective to this edition.
  • 2012From: Springer
    Evan H. Black...[et al.], editors.
  • 2006From: CRCnetBASE
    edited by H. John Smith.
  • 2011From: ScienceDirect
    [edited by] Peter J. Davis, Franklyn P. Cladis, Etsuro K. Motoyama.
  • 2017From: ClinicalKey
    [edited by] Peter J. Davis, Franklyn P. Cladis.
    1. Special characteristics of pediatric anesthesia -- 2. Behavioral development -- 3. Respiratory physiology -- 4. Cardiovascular physiology -- 5. Regulation of fluids and electrolytes -- 6. Thermoregulation: physiology and perioperative disturbances -- 7. Developmental pharmacology -- 8. Intravenous agents -- 9. Inhaled anesthetic agents -- 10. Local anesthetic agents -- 11. Opiods -- 12. Neuromuscular blocking agents -- 13. Anesthetic adjuncts -- 14. Psychological aspects of pediatric anesthesia -- 15. Perioperative preparation -- 16. Equipment -- 17. Pediatric anesthesia monitoring -- 18. Airway management -- 19. Induction, maintenance, and recovery -- 20. Blood conservation and transfusion medicine -- 21. Pain management -- 22. Regional anesthesia -- 23. Neonatology for anesthesiologists -- 24. Anesthesia for general surgery in the neonate -- 25. Anesthesia for fetal surgery -- 26. Anesthesia for congenital heart surgery -- 27. Congenital cardiac anesthesia: nonbypass procedures -- 28. Anesthesia for neurosurgery -- 29. Anesthesia for thoracic surgery -- 30. Anesthesia for general abdominal and urologic surgery -- 31. Anesthesia for pediatric otorhinolaryngologic surgery -- 32. Anesthesia for pediatric plastic surgery -- 33. Anesthesia for pediatric orthopedic surgery -- 34. Anesthesia for ophthalmic surgery -- 35. Anesthesia for organ transplantation -- 36. Anesthesia for conjoined twins -- 37. Anesthesia for the pediatric trauma patient -- 38. Anesthesia for burn injuries -- 39. Anesthesia for pediatric dentistry -- 40. Anesthesia and sedation for pediatric procedures outside the operating room -- 41. Pediatric sedation -- 42. Anesthesia for same-day surgery -- 43. Anesthesia for surgical missions -- 44. Endocrine disorders -- 45. Respiratory disorders -- 46. Cardiovascular disorders -- 47. Hematology and coagulation disorders -- 48. Oncologic disorders -- 49. Genetic muscle disorders -- 50. Malignant hyperthermia -- 51. Pediatric obesity -- 52. Special pediatric disorders -- 53. Dermatology for the anesthesiologist -- 54. Cardiopulmonary resuscitation -- 55. Critical care medicine -- 56. Cardiac intensive care unit -- 57. Safety and outcome in pediatric anesthesia -- 58. History of pediatric anesthesia -- 59. Medicolegal and ethical aspects -- 60. Statistics -- 60a. Pediatric drug dosages -- 60b. Growth curves -- 60c. Normal pulmonary function values -- 60d. Index of syndromes and their pediatric anesthetic implications -- Abbreviations.
  • McAninch, Jack W.; Smith, Donald R.; Tanagho, Emil A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012From: AccessMedicine
    Auguste H. Fortin VI, Francesca C. Dwamena, Richard M. Frankel, Robert C. Smith.
    The Medical Interview -- Data-Gathering and Relationship-Building Skills -- The Beginning of the Interview: Patient-Centered Interviewing -- Symptom-Defining Skills -- The Middle of the Interview: Clinician-Centered Interviewing -- Step 11: The End of the Interview -- Adapting the Interview to Different Situations and Other Practical Issues -- The Clinician-Patient Relationship -- Summarizing and Presenting the Patient's Story.
  • 2016From: ClinicalKey
    John M. Graham, Jr., Pedro A. Sanchez-Lara.
  • John M. Graham, Jr.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013From: ClinicalKey
    Kenneth Lyons Jones, MD., Professor of Pediatrics, Chief, Division of Dysmorphology and Teratology, University of California, San Diego, School of Medicine, La Jolla, California, Marilyn C. Jones, Professor of clinical Pediatrics, Department of Pediatrics, University of California, San Diego, School of Medicine, La Jolla, California, Clinical Service Chief, Division of Genetics, Rady Children's Hospital, San Diego, California, Miguel Del Campo, Assistant Professor, Ciècias Experimentals i de la Salut, Universitat Pompeu Fabra, Consultant in Clinical Genetics, Programa de Medicina Molecular i Genètica, Hospital Vall d'Hebron, Barcelona, Spain.
    This medical reference book provides you with complete and authoritative, yet accessible guidance to help accurately diagnose these human disorders, establish prognoses, and provide appropriate management and genetic counseling. Recognize the visual signs of each environmental and genetic abnormality by consulting more than 1,500 full-color photographs and illustrations, many from the personal collections of Drs. Smith and Jones. Find all the answers you need about normal and abnormal morphogenesis, minor anomalies and their relevance, clinical approaches to specific diagnoses, and normal standards of measurement for the entire spectrum of human malformation syndromes. Efficiently identify genetic disorders in your patients with the inclusion of nearly 20 recently recognized entities/syndromes, as well as new chapters on Microdeletions and Microduplication Syndromes.
  • 2007From: IARC
    Also available: Print – 2007
  • 2013From: Springer
    Thomas J. Rogers, Gerard J. Criner, William D. Cornwell, editors.
    Smoking and Lung Inflammation is the first book directly related to chronic lung inflammation of its kind in several respects. First, the it focuses on both basic and clinical research on COPD, and the inflammatory mechanisms that function in these diseases. Second, it is unique with respect to scope of the discussion of the unusual characteristics of the immune response which occurs in these patients. Third, it includes knowledge being gained from translational research conducted through clinical trials at several Medical Schools in the United States. Not only is this research providing information about novel drugs and therapies, but it is also advancing our understanding of the genetics of these diseases. This work will illuminate the molecular basis for these diseases, and hopefully will permit us to individualize the therapies for these diseases.
  • 2013From: Springer
    Giuseppe La Torre.
    From nicotine dependence to genetic determinants of smoking -- State of the art of smoking habits in the world -- Smoking-related diseases epidemiology -- Smoking-related cancer epidemiology -- Classical determinants of smoking initiation -- Smoking prevention in the communities -- Smoking prevention through mass media campaigns -- How to tackle smoking at the population level -- Smoking among health professionals -- Basic principles of smoking cessation techniques -- Smoking cessation among different settings -- Media and smoking cessation -- Ethical aspects of tobacco smoking -- Economic issues related to tobacco smoking -- Appendix.
  • 2010From: Springer
    Nicolaas Westerhof, Nikolaos Stergiopulos, Mark I.M. Noble.
    Viscosity -- Law of Poiseuille -- Bernoulli's equation -- Turbulence -- Arterial stenosis -- Resistance -- Inertance -- Oscillatory flow theory -- Law of Laplace -- Elasticity -- Compliance -- Cardiac muscle mechanics -- The pressure-volume relation -- The pump function graph -- Cardiac work, energy and power -- Cardiac oxygen consumption and hemodynamics -- Cardiac power and ventriculo-arterial coupling -- The coronary circulation -- Assessing ventricular function -- Wave travel and velocity -- Wave travel and reflection -- Waveform analysis -- Arterial input impedance -- The arterial windkessel -- Distributed models and tube models -- Transfer of pressure -- Mechanotransduction and vascular remodeling -- Blood flow and arterial disease -- Determinants of pressure and flow -- Comparative physiology -- Times and sines: Fourier analysis -- Basic hemodynamic elements -- Vessel segment -- Wave speed and characteristic impedance -- Basic aspects -- Books for reference -- Symbols -- Units and conversion factors.
  • 2013From: ClinicalKey
    edited by F. Paulsen and J. Waschke ; translated by T. Klonisch and S. Hombach-Klonisch.
    Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. An additional booklet containing 100 tables on muscles and nerves supports systematic study. Volume 1 "General Anatomy and Musculoskeletal System" includes the following topics: General Anatomy Trunk Upper Extremity Lower Extremity.
  • 2013From: ClinicalKey
    edited by F. Paulsen and J. Waschke ; translated by T. Klonisch and S. Hombach-Klonisch.
    Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book and the Internet content concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. Volume 3 "Head, Neck and Neuroanatomy" includes the following topics: HeadEyeEarNeckBrain and Spinal Cord.
  • 2013From: ClinicalKey
    edited by F. Paulsen and J. Waschke ; translated by T. Klonisch and S. Hombach-Klonisch.
    Sobotta - Atlas of Human Anatomy: the exam atlas for understanding, learning, and training anatomy The English-language Sobotta Atlas with English nomenclature is specifically adapted to the needs of preclinical medical students. Right from the start, the book concentrate on exam-relevant knowledge. The new study concept simplifies learning-understanding-training: Descriptive legends help the student identify the most important features in the figures. Clinical examples present anatomical details in a wider context. All illustrations have been optimized, and the lettering reduced to a minimum. An additional booklet containing 100 tables on muscles and nerves supports systematic study Volume 2 "Internal Organs" includes the following topics: Viscera of the Thorax, Viscera of the Abdomen Pelvis, and Retroperitoneal Space.
  • 2016From: Springer
    Stelios Stylianidis, editor.
    Preface -- A Brief History of Social Psychiatry -- Psychiatric Epidemiology and its Applications in Social Psychiatry -- Global Mental Health -- Psychiatric Reform in Europe -- Psychiatric Reform in Greece -- Psychoanalysis and public psychiatric care -- Mental Health Promotion: good practice in community settings -- Social Exclusion and Mental Health in Metropolitan Athens -- Psychosocial Rehabilitation and the Recovery Model: Applications in residential units in the community -- Mobile Mental Health Units in the Cyclades Islands: Mental Health Care for Adults -- Mobile Mental Health Units in the Cyclades Islands: Mental Health Care for Children and Adolescents -- A Modern Day Care Centre in Athens -- ACT and Home Care -- Counselling and Psychodynamic Psychotherapy in community settings -- Mental Health Care of itinerant populations in the community -- Modern Technologies and Social Psychiatry -- Domestic Violence and Mental Health Services in the community: Management and Evaluation -- Sexuality in individuals with severe mental illness at PSR units -- Evaluating Social Psychiatry Services -- Implications of the Socioeconomic Crisis for Staff in Community PSR units: the case of an NGO -- Staff Evaluation and Organizational Culture in Mental Health Units -- Participation and Empowerment of Users and Families -- Involuntary Hospitalization: Legal context, Epidemiology and Outcome -- Mental Health and the Financial Crisis.
  • 2008From: CRCnetBASE
    edited by Carole L. Jurkiewicz, Murphy J. Painter.
  • 2015From: Springer
    Klaus Ranta, Annette M. La Greca, Luis-Joaquin Garcia-Lopez, Mauri Marttunen, editors.
    This volume brings together research into diverse aspects of social anxiety and its clinical form, social phobia, in adolescents. Development of the condition, clinical manifestations, and evidence-based prevention and treatment strategies are all addressed, with emphasis on ways in which adolescent development and the broader family and peer context are reflected in the manifestation and treatment of symptoms. The first part of the book reviews epidemiological, neurobiological, and sociopsychological research on vulnerability factors that aim to clarify why both social anxiety and phobia intensify in adolescence. The second part focuses on the phenomenology of social anxiety and phobia in different developmental contexts and provides the reader with a review of developmentally-appropriate evidence-based assessment methods. For example, this section includes chapters on social anxiety in the school environment and in romantic relationships, social phobia in the clinical setting. The third section reviews the psychosocial prevention and treatment options for adolescent social anxiety as well as the psychopharmacological treatment of social phobia. Social Anxiety and Phobia in Adolescents will be informative and interesting for all child and adolescent psychiatrists, clinical psychologists, and psychotherapists as well as for school psychologists and counsellors.
  • 2008From: Springer
    edited by Ichiro Kawachi, S.V. Subramanian, Daniel Kim.
  • William C. Cockerham.
    PrintStatus: Not Checked OutLane Catalog Record
  • Edward O. Wilson.
    Based on a lifetime of pioneering research, preeminent naturalist Edward O. Wilson gives us a new history of human evolution, presented in an elegant and provocative narrative that promises to have reverberations in fields as diverse as anthropology and social psychology, neuroscience and 21st-century intellectual and religious history. Wilson begins by addressing three "fundamental questions" of religion and philosophy that have fascinated thinkers for centuries: Where did we come from? What are we? Where are we going? Writing that "the origin of modern humanity was a stroke of luck, good for our species for a while, bad for most of the rest of life forever," Wilson traces the rise of Homo sapiens from its infancy, drawing on his remarkable knowledge of biology and social behavior to present us with the clearest explanation ever produced as to the origin of the human condition. Wilson also reveals how "group selection" can be the only model for explaining man's origins and domination, and warns that it has now accelerated--through unregulated and untrammeled growth--to such a point that the planet as we know it is being threatened.--From publisher description. From the most celebrated heir to Darwin comes a groundbreaking book on evolution, the summa work of Edward O. Wilson's legendary career.
  • 2011From: WHO
    editors Erik Blas, Johannes Sommerfeld and Anand Sivasankara Kurup.
    "The thirteen case studies presented in this publication describe experiences with implementing public health programs that intend to address social determinants and to have a great impact on health equity. They also document the real-life challenges in implementing such programs, including the challenges in scaling up, managing policy changes, managing intersectoral processes, adjusting design and ensuring sustainability"--Publisher's description.
    Also available: Print – 2011
  • Henrie M. Treadwell, Clare Xanthos, Kisha B. Holden, editors.
    PrintStatus: Not Checked OutLane Catalog Record
    "Serious disparities continue to exist especially with regard to African-American men who continue to suffer disproportionately from poor health when compared to other racial, ethnic, and gender groups in the United States. This book covers the most important issues relating to social determinants of health and also offers viable strategies for reducing health disparities." --Excerpts from publisher description.
  • 2014From: OSO
    Jonathan Gratch and Stacy Marsella.
    Preface -- Contributors -- Introduction / Jonathan Gratch & Stacy Marsella -- On the Sociality of Emotion-Eliciting Appraisals: Two Aspects / Craig A. Smith [and] Leslie D. Kirby -- Processes of Emotional Meaning and Response Coordination / Brian Parkinson -- Challenge, Threat and Social Influence in Digital Immersive Virtual Environments / Jim Blascovich -- Requirements for a process model of appraisal from a social functional perspective / Stacy Marsella, Jonathan Gratch -- Modeling Theory of Mind and Cognitive Appraisal with Decision-Theoretic Agents / David V. Pynadath, Mei Si, [and] Stacy C. Marsella -- Automatic Facial Expression Recognition / Jacob Whitehill, Marian Stewart Bartlett, [and] Javier R. Movellan -- Toward effective automatic recognition systems of emotion in speech / Carlos Busso, Murtaza Bulut, [and] Shrikanth Narayanan -- The Role of Context in Affective Behavior Understanding / Louis-Philippe Morency -- Computational Models of Expressive Behaviors for a Virtual Agent / Radoslaw Niewiadomski, Sylwia Julia Hyniewska, [and] Catherine Pelachaud -- Early Emotional Communication: Novel Approaches to Interaction / Daniel S. Messinger, Mohammad H.Mahoor, Sy-Miin Chow, J. D. Haltigan, StevenCadavid, [and] Jeffrey F. Cohn -- Using social agents to explore theories of rapport and emotional resonance / Jonathan Gratch, Sin-Hwa Kang, [and] Ning Wang -- index.
  • Susannah Fox.
    This report sets out to illuminate the different ways people seek health information as well as how people use online social tools to share knowledge with loved ones, fellow patients, and caregivers.
  • 2017From: Oxford Medicine Online
    edited by Jeff French.
    The case for social marketing in public health / Jeff French -- Key principal, concepts, and techniques of social marketing / Jeff French -- Social marketing planning / Jeff French -- Evaluation of social marketing programmes / Adam Crosier and Dominic McVey -- Social marketing and public health strategy / Jeff French -- Behaviour and how to influence it / Jeff French -- Generating insight and building segmentation models in social marketing / Dominic McVey and Adam Crosier -- Commissioning social marketing / Jeff French -- Social marketing on a small budget / Jeff French -- Building social programme coalitions / Jeff French -- Ethical issues in social marketing / Lynne Eagle, Stephan Dahl, and David Low -- Using digital and social media platforms for social marketing / Melissa K. Blair -- Social franchising: Strengthening health systems through private sector approaches / Julie McBride, Kim Longfield, Dana Sievers, and Dominic Montagu.
  • 2013From: Springer
    Bertalan Meskó.
    Social media has been clearly changing the way medicine is practiced and healthcare is delivered. Medical professionals must be able to meet the special needs of technology-aware patients and use digital technologies in their work and communications properly. Each physician should find the tools that will assist them in their workflow, and patients need to be educated how to use the internet. It is the responsibility of medical professionals to contribute to this process. The constantly evolving digital world must be used in the practice of medicine to improve the care of patients. However, the only way to do so effectively is via evidence-based, meaningful and strategic use. Social Media in Clinical Practice provides practical guidance in this mission and is thus essential reading for all medical personal looking into approaching this for the first time.
  • 2013From: Springer
    Peter A. Hall, editor.
  • by Michael E. Porter and Scott Stern ; with Michael Green.
    Measures national progress in delivering social and environmental value to citizens. Includes statistical rankings by country in various areas, including health and wellbeing. It is designed as a complement to GDP and other economic indicators to provide a more holistic understanding of countries' overall performance.
  • 2016From: Cambridge
    edited by Judith A. Hall, Northeastern University, Marianne Schmid Mast, University of Lausanne, Tessa V. West, New York University.
    Part I: Domains of accurate interpersonal perception -- Part II: Correlates of interpersonal accuracy -- Part III: Conclusions.
  • James Joseph Wagner.
    People with severe physical disabilities who have non-technical backgrounds are unlikely candidates to be able to operate vocational assistive robots. Such robotic devices have been costly, complex, programmable only by experts, and prohibitive to user changes. This dissertation describes the design approach created in the development of a small desktop robot system called the Professional Vocational Assistant Robot (ProVAR). ProVAR deals explicitly with the social aspects of human-robot interaction to help individuals with tetraplegia to use the robot. This design approach was heavily influenced by the theory of Social Responses to Communication Technologies (SRCT) and by psychology research that shows the power of a team in complex command, design and learning scenarios. The SRCT concept holds that people's reactions and interactions with computers and other new media entities follow the same social rules used in human-human interactions. If those reactions can be enhanced, the success of assistive robotic systems dependent on them can also be increased. The leveraging of social responses can increase tolerance for the robotic systems' difficulties, and thus increase the chance of adoption and sustained use of the assistive devices by lay users not experienced in computers, robots, or mechanical control devices. A new theory, growing out of SRCT, was proposed. "Social Responses to Somatic Technology" (SRST) guided the development of ProVAR. It is based on a robot users perception that a somatic, e.g., robotic, technology device is, in fact, a social entity. As does a human social entity, each technological social entity consists of two components: the "body" and the "mind." The ProVAR System was designed with two complete social entities, or personalities; both induce social responses. Each of ProVAR's two personalities is expected to maintain a personal relationship with the users, in this case, with an individual with severe physical disabilities and with the occupational therapist responsible for his/her rehabilitation. ProVAR's graphical user interface, named "Jiminey, " is primarily considered by the user to be a mind: a smart consultant/coach. ProVAR's robotic arm, "Pinocchio, " is primarily perceived by the user to be a body: the down-to-earth do'er itself. Even though each of these social entities does have both a body and a mind, each personality's different dominant characteristic allows the user to perceive that he/she is functioning as a teammate with two other distinct entities. These three partners work together to help manage and take advantage of the special capabilities of the ProVAR System to complete desired tasks. During Experiment 1, ProVAR showed 100% of novice users able independently to execute both preprogrammed tasks and also the more complicated manipulation of existing tasks and creation of new ones. ProVAR's SRST-inspired design is effective, with seven of eight metrics positively ranked by users. One additional finding showed that training first on the user interface alone without the presence of the robotic arm was not time effective. A further examination of the application of the SRST concept of "Social Entity = Body + Mind" was done in Experiment 2, studying the effect of the body and the mind of the robotic arm being perceived not to be co-located but in separate locations. Results showed that usability was ranked higher by the study participants if the arm (the body) was perceived as autonomous, i.e., controlling itself (by its mind) with an internal inboard computer, rather than the arm being remote-controlled, i.e., teleoperated (by its mind), in a computer located in another room.
  • Meredith G. Farkas.
    PrintStatus: Not Checked OutLane Catalog Record
    What is social software? -- Blogs -- Blogs in libraries : practical applications -- RSS -- Wikis -- Online communities -- Social networking -- Social bookmarking and collaborative filtering -- Tools for synchronous online reference -- The mobile revolution -- Podcasting -- Screencasting and vodcasting -- Gaming -- What will work @ your library -- Keeping up : a primer -- Future trends in social software.
  • 2015From: Springer
    Serge Morand, Jean-Pierre Dujardin, Régine Lefait-Robin, Chamnarn Apiwathnasorn, editors.
    Chapter 1: Introduction to socio-ecological dimensions of infectious diseases and health in Southeast Asia. -- Part 1: Infectious Diseases and Societies -- Chapter 2: Climate, environment and epidemic febrile diseases: A view from Chinese medicine -- Chapter 3: Long life of people living with HIV/AIDS and the practice of medical power -- Chapter 4: Socio-environmental global changes and infectious diseases: Interdisciplinary approach applied to tourism studies -- Part 2: Socio-Ecosystems and Health -- Chapter 5: Heavy metals contamination in the ecosystem of Mae Tang reservoir in Northern Thailand -- Chapter 6: Water and health: What is the risk and visible burden of the exposure to environmental contaminations? Insights from a questionnaire-based survey in Northern Thailand -- Chapter 7: Melioidosis in Laos -- Part 3: Global Changes, Land Use Changes and Vector-Borne Diseases -- Chapter 8: Adaptation of mosquito vectors to salinity and its impact on mosquito-borne disease transmission in the South and Southeast Asian tropics -- Chapter 9: The malaria landscape: Mosquitoes, transmission, landscape, insecticide resistance and integrated control in Thailand -- Chapter 10: Rubber plantations as a mosquito box amplification in South and South-East Asia -- Part 4: Monitoring and Data Acquisition -- Chapter 11: Rescuing public health data -- Chapter 12: The new science of metagenomics and the challenges of its use in both developed and developing countries -- Chapter 13: Barcoding, biobanking, e banking: From ecological to ethical and legal aspects. Insights from the PathodivSEA project -- Part 5: Managing Health Risks -- Chapter 14: Methods for prioritization of diseases: Case study of zoonoses in South-East Asia -- Chapter 15: Managing global risks: Vietnamese poultry farmers and avian flu -- Chapter 16: The OIE Strategy to address threats at the interface between humans, animals and ecosystems -- Part 6: Developing Strategies -- Chapter 17: Business for biodiversity and ecosystem services -- Chapter 18: Bridging the gap between conservation and health -- Chapter 19: Implementation of the One health strategy. Lessons learnt from community based natural resource programs for communities' empowerment and equity within an Eco health approach.
  • 2012From: Springer
    John Martyn Chamberlain.
    This book provides a comprehensive examination of the complex issues surrounding the regulation of the medical profession. It offers up-to-date information on the current legislative framework and institutional arrangements surrounding the regulation in the United Kingdom. Well organized and written in an accessible way, it offers an insight into key sociological theories surrounding medical regulation. It gives a historically situated analysis of the contemporary relationship between medicine, the state and the public, and an overview of relevant social scientific research. Case studies highlight the practical or applied circumstances in which issues can occur. Readers will gain insight into possible future directions for medical governance.
  • 2013From: Wiley
    edited by Natalie Armstrong and Helen Eborall.
    "The Sociology of Medical Screening: Critical Perspectives, New Directions presents a series of readings that provide an up-to-date overview of the diverse sociological issues relating to population-based medical screening. Features new research data in most of the contributions. Includes contributions from eminent sociologists such as David Armstrong, Stefan Timmermans, and Alison Pilnick. Represents one of the only collections to specifically address the sociology of medical screening"--Provided by publisher.
  • 2013From: Springer
    edited by Lucio Annunziato.
    Also available: Print – 2013
  • 2005From: Springer
    Kevin Coward, Mark D. Baker, editors.
    Also available: Print – 2005
  • 2006From: CRCnetBASE
    W.C.K. Poon, D. Andelman, [editors].
  • 2017From: ClinicalKey
    Jean Carruthers, Alastair Carruthers, Jeffrey S. Dover, Murad Alam.
  • edited by John A. Persing, Gregory R.D. Evans.
    PrintStatus: Not Checked OutLane Catalog Record
  • Yingxu Wang.
  • 2008From: CRCnetBASE
    Julio Sanchez, Maria P. Canton.
  • 2011From: Springer
    Hamid R. Arabnia, Quoc-Nam Tran, editors.
    Also available: Print – 2011
  • 2008From: CRCnetBASE
    edited by Mark Tibbett and David O. Carter.
    Nature, distribution, and origin of soil materials in the forensic comparison of soils / Robert W. Fitzpatrick -- Cadaver decomposition and soil: processes / David O. Carter and Mark Tibbett -- The role of soil organisms in terrestrial decomposition / David W. Hopkins -- Soil fungi associated with graves and latrines: towards a forensic mycology / Naohiko Sagara, Takashi Yamanaka, and Mark Tibbett -- The role of invertebrates in terrestrial decomposition: forensic applications / Ian R. Dadour and Michelle L. Harvey -- The decomposition of hair in the buried body environment / Andrew S. Wilson -- The decomposition of materials associated with buried cadavers / Robert C. Janaway -- Decomposition chemistry in a burial environment / Shari L. Forbes -- Potential determinants of postmortem and postburial interval of buried remains / Shari l. Forbes -- Principles and methodologies of measuring microbial activity and biomass in soil / Phil Brookes -- Methods of characterizing and fingerprinting soils for forensic application / Lorna A. Dawson ... [et al.].
  • 2009From: Springer
    Véronique Blanchet, Agnès Brabant.
  • 2008From: Springer
    Eckart Eich.
  • 1997From: ScienceDirect
    edited by Gregg B. Fields.
    Also available: Print – 1997
  • David Scott, Elaine A. Sia, Mirjana Brockett, William D. Fixsen, Diane K. Lavitt.
    PrintStatus: Not Checked OutLane Catalog Record
    1. The Genetics Revolution in the Life Sciences -- pt. I. TRANSMISSION GENETICS -- 2. Single-Gene Inheritance -- 3. Independent Assortment of Genes -- 4. Mapping Eukaryote Chromosomes by Recombination -- 5. The Genetics of Bacteria and Their Viruses -- 6. Gene Interaction -- pt. II. FROM DNA TO PHENOTYPE -- 7. DNA: Structure and Replication -- 8. RNA: Transcription and Processing -- 9. Proteins and Their Synthesis -- 10. Gene Isolation and Manipulation -- 11. Regulation of Gene Expression in Bacteria and Their Viruses -- 12. Regulation of Gene Expression in Eukaryotes -- 13. The Genetic Control of Development -- 14. Genomes and Genomics -- pt. III. MUTATION, VARIATION, AND EVOLUTION -- 15. The Dynamic Genome: Transposable Elements -- 16. Mutation, Repair, and Recombination -- 17. Large-Scale Chromosomal Changes -- 18. Population Genetics -- 19. The Inheritance of Complex Traits -- 20. Evolution of Genes and Traits.
  • 2007From: Springer
    [edited by] Patrick Augustijns, Marcus Brewster.
  • 2013From: Springer
    John G. Taylor.
    This book details a model of consciousness supported by scientific experimental data from the human brain. It presents how the Corollary Discharge of Attention Movement (CODAM) neural network model allows for a scientific understanding of consciousness as well as provides a solution to the Mind-Body problem. The book provides readers with a general approach to consciousness that is powerful enough to lead to the inner self and its ramifications for the vast range of human experiences. It also offers an approach to the evolution of human consciousness and features chapters on mental disease (especially schizophrenia) and on meditative states (including drug-induced states of mind). Solving the Mind-Body Problem bridges the gap that exists between philosophers of mind and the neuroscience community, allowing the enormous weight of theorizing on the nature of mind to be brought to earth and put under the probing gaze of the scientific facts of life and mind.
  • 2006From: Springer
    edited by Peter Sutovsky.
    Nuclear remodeling and nuclear reprogramming for making transgenic pigs by nuclear transfer / Randall S. Prather -- Somatic cell nuclei in cloning : strangers traveling in a foreign land / Keith E. Latham, Shaorong Gao, and Zhiming Han -- Cloning cattle : the methods in the madness / Bjørn Oback and David N. Wells -- Centrosome inheritance after fertilization and nuclear transfer in mammals / Qing-Yuan Sun and Heide Schatten -- Developmental, behavioral, and physiological phenotype of cloned mice / Kellie L.K. Tamashiro ... [et al.] -- Nucleolar remodeling in nuclear transfer embryos / Jozef Laurincik and Poul Maddox-Hyttel -- Somatic cell nuclear transfer (SCNT) in mammals : the cytoplast and its reprogramming activities / Josef Fulka, Jr. and Helena Fulka -- Mitochondrial DNA inheritance after SCNT / Stefan Hiendleder -- Activation of fertilized and nuclear transfer eggs / Christopher Malcuit and Rafael A. Fissore.
    Also available: Print – 2006
  • 2006From: Springer
    volume editors, A. Mujib, J. Šamaj.
  • Anthony Cerulli.
    1. Introduction: Narrativitzing the body -- 2. The Patient's body in Indian medical literature -- 3. Fever -- 4. Miscarriage -- 5. The King's disease -- 6. The Joy of life [Jīvānandanam] of Ānandarāyamakhin -- 7. Conclusion: Medical narratives and the narrativized patient.
  • 2012From: Springer Protocols
    edited by Shree Ram Singh.
    Current thoughts on the therapeutic potential of stem cell / Pranela Rameshwar -- Unique FACS method to isolate stem cells in planarian / Tetsutaro Hayashi and Kiyokazu Agata -- Identification of neural dtem cells in the Drosophila larval brain / Mo Weng, Hideyuki Komori, and Cheng-Yu Lee -- Generation and staining of intestinal stem cell lineage in adult midgut / Shree Ram Singh [and others] -- Developing a quantitative in vivo tissue reconstitution assay to assess the relative potency of candidate populations of mouse oesophageal epithelial cells / Daniel Croagh [and others] -- Identification, isolation, and culture of intestinal epithelial stem cells from murine intestine / A.D. Gracz, B.J. Puthoff, and S.T. Magness -- Isolation and characterization of distal lung progenitor cells / Barbara Driscoll [and others] -- Transplantation of mouse fetal liver cells for analyzing the function of hematopoietic stem and progenitor cells / Kristbjorn Orri Gudmundsson, Steven W. Stull, and Jonathan R. Keller -- Convenient and efficient enrichment of the CD133+ liver cells from rat fetal liver as a source of liver stem/progenitor cells / Weihui Liu, Nan You, and Kefeng Dou -- Assessing the potential clinical utility of transplantations of neural and mesenchymal stem cells for treating neurodegenerative diseases / Laurent Lescaudron [and others] -- Functional identification of neural stem cell-derived oligodendrocytes / Sofia Grade [and others] -- Stem/progenitor cells in murine mammary gland : isolation and functional characterization / Abhik Bandyopadhyay, Qiaoxiang Dong, and Lu-Zhe Sun -- Reporter assay to detect transfer and targeting of miRNAs in stem cell-breast cancer co-cultures / Steven J. Greco, Shyam A. Patel, and Pranela Rameshwar -- Isolation, culture, and osteogenic/chondrogenic differentiation of bone marrow-derived mesenchymal stem cells / Susanne Grassel, Sabine Stockl, and Zsuzsa Jenei-Lanzl -- Obtaining freshly isolated and cultured mesenchymal stem cells from human adipose tissue / Andrew C. Boquest and Philippe Collas -- Collection, processing, and banking of umbilical cord blood stem cells for transplantation and regenerative medicine / Michael S. Badowski and David T. Harris -- Generation of functional islets from human umbilical cord and placenta derived mesenchymal stem cells / Sachin Kadam, Vijayendran Govindasamy, and Ramesh Bhonde -- Isolation and characterization of human prostate Stem/Progenitor Cells / Changyong Guo, Baohui Zhang, and Isla P. Garraway -- Isolation and expansion of adult cardiac stem/progenitor cells in the form of cardiospheres from human cardiac biopsies and murine hearts / Isotta Chimenti [and others] -- Isolation and differentiation of human cardiomyocyte progenitor cells into cardiomyocytes / Anke M. Smits, Angelique A. van Oorschot, and Marie-Jose Goumans -- Isolation, expansion, and characterization of human islet-derived progenitor cells / Mugdha V. Joglekar and Anandwardhan A. Hardikar -- Isolation and characterization of resident mesenchymal stem cells in human glomeruli / Stefania Bruno and Giovanni Camussi -- Endothelial colony-forming progenitor cell isolation and expansion / Nicole A. Hofmann, Andreas Reinisch, and Dirk Strunk -- Isolation and characterization of stem cell-enriched human and canine hair follicle keratinocytes / Manabu Ohyama and Tetsuro Kobayashi -- Human salivary gland stem cells : isolation, propagation, and characterization / Silke Schwarz and Nicole Rotter -- Identification, isolation, characterization, and banking of human dental pulp stem cells / Virginia Tirino [and others] -- Isolation and differentiation potential of fibroblast-like stromal cells derived from human skin / Hsing-I Huang and Chung-Zu Wu -- Immortalization of human mesenchymal stromal cells with telomerase and red fluorescence protein expression / Chao-Ling Yao and Shiaw-Min Hwang -- Genetic modification of mesenchymal stem cells / Andreia Escosteguy Vargas [and others] -- Methodology, biology and clinical applications of human mesenchymal stem cells / Melissa Camassola [and others] -- In vitro production of enucleated red blood cells from hematopoietic stem and progenitor cells / Kenichi Miharada and Yukio Nakamura -- Methods for cancer stem cell detection and isolation / Virginia Tirino [and others] -- Biocompatible nanoparticle labeling of stem cells and their distribution in brain / Ashish K. Rehni [and others].
  • 2006From: ScienceDirect
    edited by Fred Nyberg.
  • 2010From: IARC
    Also available: Print – 2010
  • 2010From: IARC
    Also available: Print – 2010
  • Ridenour, Nina.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2002From: IARC
    Also available: Print – 2002
  • edited by Miguel Maroto, Neil V. Whittock.
    Formation and differentiation of avian somite derivatives / Bodo Christ and Martin Scaal -- Avian somitogenesis : translating time and space into pattern / Beate Brand-Saberi, Stefan Rudloff, and Anton J. Gamel -- Genetic analysis of somite formation in laboratory fish models / Christoph Winkler and Harun Elmasri -- Old wares and new : five decades of investigation of somitogenesis in Xenopus laevis / Duncan B. Sparrow -- Role of delta "like" in mammalian somitogenesis and vertebral column formation / Gavin Chapman and Sally L. Dunwoodie -- Mesp-family genes are required for segmental patterning and segmental border formation / Yumiko Saga and Yu Takahashi -- BHLH proteins and their role in somitogenesis / Miguel Maroto ... [et al.] -- Mouse mutations disrupting somitogenesis and vertebral patterning / Kenro Kusumi, William Sewell, and Megan L. O'Brien -- Defective somitogenesis and abnormal vertebral segmentation in man / Peter D. Turnpenny.
  • Alexander Gray Vaughan.
    This thesis encompasses three projects at the intersection of genetics, behavior, and neurobiology in the fruitfly, Drosophila melanogaster. The major work presented is an investigation of the afferent auditory system in D. melanogaster. The afferent auditory system of D. melanogaster arises from the Johnston's Organ in the second antennal segment, from which mechanosensory neurons project to a protocerebral region known as the Antennomechanosensory and Motor Complex (AMMC). The antennal mechanosensory system in Drosophila is used in multiple contexts, including vestibular mechanosensation, wind sensitivity, and courtship hearing. During courtship, male flies present a stereotypic pulse song as well as a hum-like sine-song to female flies; these stimuli are species-specific and critical to female receptivity. Using a large enhancer-Gal4 collection, I identify 12 candidate cell types within the AMMC, divided into 7 types of projection neurons as well as 5 types of local AMMC interneurons. I tested each of these cell types for its effect on courtship hearing by testing the effect of neuronal silencing on a) female receptivity, and b) a male locomotor response (Song-Induced Locomotion). These tests reveal that the activity of one class of projection neuron (aPN1), and one class of local interneuron (aLN(al)) are critical to courtship hearing in both male and female flies. Other cell types appear to be dispensable for courtship hearing, and may play a role in non-courtship related mechanosensation. To help confirm that these phenotypes are not specific to neuronal silencing, I also hyperactivated each cell type using the temperature-sensitive dTrpA1 reagent; these results confirm that aPN1 and aLN(al) alone are necessary for courtship hearing. Overall this work identifies a set of parallel pathways from the AMMC leading to the ventrolateral protocerebrum (VLPR), but reveal that only one of these pathways is necessary for courtship hearing. The structure of this circuit is analogous to the multi-lineage projection identified in D. melanogaster olfaction, in which a parallel pathways share a common projection but carry independent information. In addition to this work, I also discuss an investigation of the role of abnormal-chemosensory jump 6 (acj6) on escape behaviors, as well as an investigation of the expression of doublesex (dsx) in the nervous system.
  • Frederick W. Kremkau ; with contributions by Flemming Forsberg.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction -- Ultrasound -- Transducers -- Instruments -- Doppler principles -- Artifacts -- Performance and safety -- Review.
  • 2015From: ScienceDirect
    edited by Wei Guo.
    Sorting and Recycling Endosomes provides the latest information on endosomes, the receiving compartment for endocytosed cargos, and the donor compartment and sorting station for cargos designated to lysosomes, Golgi, or plasma membrane. In recent years, the importance of endosomes as a sorting and recycling compartment has become increasingly appreciated. As such, scientists from various fields of cell biology, membrane traffic, and beyond, see the needs to communicate and learn about the methods used to investigate the dynamics and functions of endosomes. This book brings together specialists from the field who contribute their expertise on a broad range of biomedical topics that will provide ideal reading for researchers interested in endosomal sorting and recycling. This volume covers the approaches necessary to study the key components that mediate the generation and transport of membrane-bounded carriers from the endosomes, and how membrane trafficking machinery is coordinated with cytoskeletons during these processes. In addition to studies carried out in mammalian cells, other model systems such as worm and yeast are also included.
  • 2009From: Springer
    Patrick Ben Soussan, Eric Dudoit.
  • 2011From: Springer
    Luciano L'Abate.
  • 2008From: Springer
    edited by P. Michael Conn.
  • edited by Robin L. Anderson.
    PrintStatus: Not Checked OutLane Catalog Record
    Paleopathology and primitive medicine -- The Middle East in antiquity -- China and India in antiquity -- Greece -- Rome and Byzantium -- Europe, 500-1500 -- Medicine in the Muslim world and the Americas, 700-1500 -- The Renaissance and the scientific revolution: technical and theoretical change -- Europe, 1500-1800: health, disease, trauma, and society -- The nineteenth century: the development and spread of Western medicine -- The nineteenth century: change and upheaval -- The twentieth century: advances and challenges -- The twentieth century: new enemies, old nemeses -- A brave new century: dilemmas in twenty-first-century medicine.
  • Anna Aulette-Root, Floretta Boonzaier, and Judy Aulette.
    Women living with HIV -- The Cape Coloured community -- A support group for HIV-positive women in Cape Town -- Marginalizing the marginalized through multiple stigmas -- Disclosure for better or worse -- Staking a claim as normal through work and relationships with men -- Care work -- Care work and violent men -- Women's bodies -- Lessons for the world.
  • 1971From: Google Books
    compiled by Division of Health Facilities in collaboration with the Advisory Hospital Council.
    Also available: Print – 1971
  • 1973From: Google Books
    compiled by Bureau of Health Facilities and Services in collaboration with the Advisory Hospital Council.
    Also available: Print – 1973
  • 2013From: Springer
    edited by Amelie G. Ramirez, Ian M. Thompson, Leonel Vela.
    As America's most populous state goes, so goes the nation. And within that state, the 38 counties comprising South Texas--a highly populated, largelyHispanicarea characterized by high uninsured rates and low numbers of health care providers--are emblematic of nationwide crises in public health. The South Texas Health Status Review: A Health Disparities Roadmapbrings health care disparities to light in instructive detail. Over thirty key health conditions and risk factors, such as breast cancer, diabetes, obesity, tuberculosis, smoking and alcohol use, lead exposure, birth defects, and homicide rates, are analyzed by age, sex, race/ethnicity, and location (urban or rural), and the results compared with the rest of Texas and the nation as a whole. A section on conclusions and recommendations outlines factors contributing to these conditions and offers suggestions for improvement. These important data should stimulate further population studies and provide impetus for targeted public health interventions and community outreach programs to reduce health inequities and advance care access in the state and the U.S. at large. Major health issues covered in the report include: Communicable diseases Cancer incidence and mortality Maternal and child health Chronic diseases Behavioral risk factors in adults Environmental health issues Suicide, homicide, and vehicular mortality The South Texas Health Status Reviewcontains valuable lessons for researchers in health promotion and health disparities, as well as community health professionals. Policymakers involved in reducing health disparities will find it especially useful.
  • PrintStatus: Not Checked OutLane Catalog Record
  • 2016From: Springer
    Arnauld E. Nicogossian, Richard S. Williams, Carolyn L. Huntoon, Charles R. Doarn, James D. Polk, Victor S. Schneider, editors.
    PART I. Introduction to space medicine -- 1. Evolution of human capabilities and space medicine -- 2. The environment of space exploration -- 3. Living and working in space: an overview of physiological adaptation, performance, and health risks -- PART II. Spacecraft Environments -- 4. Toxicology -- 5. Microbiology -- 6. Acoustics and audition -- 7. Radiation health and protection -- PART III. Space Flight and Crew Health: Adaptation, Pathophysiology, Rehabilitation, and Countermeasures -- 8. Cardiopulmonary system: aeromedical considerations -- 9. Neurology -- 10. Regulatory physiology -- 11. Metabolism and nutrition -- 12. Clinical pharmacology and therapeutics -- 13. Musculoskeletal adaptation to space flight -- 14. Behavioral health and performance -- PART IV. Occupational Health and Safety Issues in Space Flight -- 15. Prinicples of crew health monitoring and care -- 16. International dimension of space medicine -- PART V. Ground-based and academic training programs -- 17. Simulations and analogs (test-beds) -- 18. Training in space medicine -- PART VI. Future Perspectives -- 19. Commercial space tourism and space as a biomedical laboratory.
  • 2008From: Springer
    by Nick Kanas, Dietrich Manzey.
  • 2011From: ScienceDirect
    edited by Stanislas Dehaene and Elizabeth M. Brannon.
    "The study of mathematical cognition and the ways in which the ideas of space, time and number are encoded in brain circuitry has become a fundamental issue for neuroscience. How such encoding differs across cultures and educational level is of further interest in education and neuropsychology. This rapidly expanding field of research is overdue for an interdisciplinary volume such as this, which deals with the neurological and psychological foundations of human numeric capacity. A uniquely integrative work, this volume provides a much needed compilation of primary source material to researchers from basic neuroscience, psychology, developmental science, neuroimaging, neuropsychology and theoretical biology."--Publisher's description.
  • 2008From: Springer
    G. Baier, B. Schraven, U. Zügel, A. von Bonin, editors.
  • 2010From: Springer
    Adriano Ferrari, Giovanni Cioni.
    Cerebral palsy detection : from John Little to the present / Giovanni Cioni, Paola B. Paolicelli -- Guide to the interpretation of cerebral palsy / Adriano Ferrari, Silvia Alboresi -- Functional diagnosis in infants and in very young children : early predictive signs / Giovanni Cioni, Andrea Guzzetta, Vittorio Belmonti -- Motor defects / Adriano Ferrari -- Perceptive defects / Adriano Ferrari -- Praxic organization disorders / Simonetta Muzzini, Federico Posteraro, Roberta Leonetti -- Visual and oculomotor disorders / Andrea Guzzetta ... [et al.] -- Neuropsychological evaluation / Daniels Brizzolara, Paola Brovedani, Giovanni Ferretti -- Emotional, behavioral and social disorders in children and adolescents with cerebral palsy / Gabriele Masi, Paolo Brovedani -- Observing interactions / Sandra Maestro -- Critical aspects of classifications / Adriano Ferrari -- Kinematic classification / Adriano Ferrari -- Tetraplegic forms / Adriano Ferrari ... [et al.] -- Dysperceptive forms / Silvia Alboresi ... [et al.] -- Forms of diplegia / Adriano Ferrari ... [et al.] -- Forms of hemiplegia / Giovanni Cioni ... [et al.].
  • 2007From: Springer
    edited by Rima B. Franklin and Aaron L. Mills.
    Statistical analysis of spatial structure in microbial communities / Rima B. Franklin, Aaron L. Mills -- Bacterial interactions at the microscale - linking habitat to function in soil / Naoise Nunan ... [et. al] -- Spatial distribution of bacteria at the microscale in soil / Arnaud Dechesne, Céline Pallud, Geneviève L. Grundmann -- Analysis of spatial patterns of rhizoplane colonization / Guy R. Knudsen, Louise-Marie Dandurand -- Microbial distributions and their potential controlling factors in terrestrial subsurface environments / R. Michael Lehman -- Spatial organisation of soil fungi / Karl Ritz -- Spatial heterogeneity of planktonic microorganisms in aquatic systems / Bernadette Pinel-Alloul, Anas Ghadouani -- The interrelationship between the spatial distribution of microorganisms and vegetation in forest soils / Sherry J. Morris, William J. Dress.
  • 2009From: CRCnetBASE
    Poh Chin Lai, Fun Mun So, Ka Wing Chan.
    GIS concepts and operations -- GIS and geographic data -- Spatial analysis software and methods -- Point pattern methods of disease analysis -- Areal methods of disease analysis -- Interpolation and associative analysis -- Initiating a GIS project in spatial epidemiology -- Current GIS research in health care and disease analyses.
  • Jeremy B. Chang.
    Not only do biological systems consist of an extraordinarily complex cast of molecules, these molecules are well-organized in space: first into compartments, which form cells, which act in concert as tissues, which finally make up organisms. This thesis focuses on specific examples of how complicated biological systems create and maintain their intricate spatial organization. The tools of mathematical modeling have greatly assisted scientists' understanding of spatial patterning. In particular, models can help to distill a complicated phenomenon into its core logic. Chapter 1 is an overview of two types of spatial phenomena, Turing patterns and trigger waves, in which a relatively simple mathematical model is able to capture the most salient characteristics of the spatial pattern. Chapter 2 details how trigger waves of mitotic activity help to spatially coordinate the events of mitosis across the relatively large Xenopus laevis egg. We present a simple mathematical model that shows the plausibility of such waves, as well as a detailed experimental study on the existence and dynamics of such waves in Xenopus eggs and extracts. In Chapter 3, I discuss methods that greatly enhance the ability to visualize Xenopus extract using fluorescence microscopy. Traditional methods are only able to visualize a fixed cell cycle state or a single transition from one state to another. The method presented takes advantage of the fact that Xenopus extracts execute many more cell cycles on Teflon versus other materials such as glass and polydimethylsiloxane (PDMS). Using a Teflon-coated glass coverslip, we were able to achieve high-resolution imaging using spinning disk confocal microscopy on extracts that can execute multiple (about six at a minimum) cell cycles.
  • 2007From: Springer
    edited by Fred Mast and Lutz Jäncke.
  • Tony Yu-Chen Tsai.
    Positive and negative feedback loops are two of the most ubiquitous network motifs in biological systems. When a positive feedback loop and a negative feedback loop are coupled together, rich dynamics can emerge. Among these, oscillations in time and space, and pulses of protein activity are some of the commonly observed phenomena in a biological system. In this thesis, we started by computationally study the benefit of a positive feedback in an oscillator, and concluded that oscillators running on interlinked positive-and-negative feedback loops are more robust and tunable in period than the oscillators with only the negative feedback. We then focused on the Xenopus laevis embryonic cell cycle oscillator, a well characterized biochemical oscillator that runs on interlinked positive-and-negative feedback loops. We identified a transition of oscillator topology during Xenopus early development, from the long first cell cycle that depends critically on Wee1/Cdc25 mediated positive feedback, to the short subsequent cell cycles in which the positive feedback is dispensable. Using the human neutrophil-like HL60 cells, we studied the spatiotemporal dynamics of cytoskeleton proteins. We identified a perfect coupling between the protruding front and the retracting rear of a migrating HL60 cells. Myosin exhibits dynamic flashes at the rear of the cell, and the time scale of the flashes depends on local positive and negative feedback loops. When the duration of the myosin flashes is perturbed, the cell exhibits difficulties in turning and has inefficient chemotaxis. We also performed a statistical study comparing the shape and migration dynamics of HL60 cells, and provided evidence of a close correlation between the two phenotypes. Our results showed that the spatiotemporal protein dynamics allowed by proper regulation of interlinked positive-and-negative feedback loops is important in many examples in biology.
  • 2012From: Springer
    Adel E. Berbari, Giuseppe Mancia, editors.
    This volume is a cutting-edge review of the latest findings on key scientific and clinical issues in hypertension, with an integration of different new specific topics into the general knowledge of how to understand the pathophysiology and correctly diagnose and treat this chronic condition, which still represents the first cause of death in the world.Among the topics included in the book the reader will find some forms of hypertension which are frequently encountered in clinical practice and on which new important evidence is available, such as high-normal blood pressure (also termed pre-hypertension), white-coat and masked hypertension, and high blood pressure in the elderly and the very elderly. These emerging aspects are discussed in detail, along with chapters on issues of great current interest, such as the way to assess and how to treat asymptomatic organ damage, emerging cardiovascular risk factors such as short and long-term blood pressure variability, cognitive impairment and dementia. The book also deals with the changing concepts in the management of hypertension and antihypertensive pharmacotherapy, and addresses specific topics which are rarely discussed in clinical medicine volumes, including hypertension in post-menopausal women, hormonal replacement therapy, inflammatory disorders, sexual dysfunction with treatment, and the effect of Ramadan fasting on blood pressure. This ready to hand but encompassing volume proves to be a comprehensive updating tool to professionals and clinical practitioners managing patients with hypertension.
  • 2013From: Springer
    Amol Saxena, editor.
    Special Procedures in Foot and Ankle Surgery is designed for foot and ankle surgeons who desire to take their skill set to the next level. Advanced surgical techniques are highlighted for some of the more difficult problems encountered by foot and ankle surgeons such as Charcot deformity, chronic tendinopathies, osteochondral lesions, total ankle arthroplasty, tumors, adult flatfoot, cavus and Rheumatoid foot. The latest techniques, including endoscopic approaches are highlighted. This book is designed for all levels of foot and ankle surgeons to better care for their patients.
  • 2007From: Springer
    Tim Manser, editor.
    Pattern recognition by B cells: the role of antigen repetitiveness versus toll-like receptors -- The multifunctional role of antibodies in the protective resonse to bacterial T cell-independent antigens -- The important anddiverse roles of antibodies in the host response to Borrelia infections -- A distinct role for B1b lymphocytes in T cell-independent immunity -- Secretory immunity following mutans streptococcal infection or immunization.
    Also available: Print – 2007
  • [the Robert Graham Center: Policy Studies in Family Medicine and Primary Care ; Robert L. Phillips, Jr., Martey S. Dodoo, Stephen Petterson, Imam Xierali, Andrew Bazemore, Bridget Teevan, Keisa Bennett, Cindy Legagneur, JoAnn Rudd ; and Julie Phillips, Michigan State University College of Human Medicine ; Josiah Macy, Jr. Foundation Grant B07-09 ...].
    1. What We Know About Factors Affecting Medical Student & Resident Career Decisions -- 2. Study Aims, Questions, Methods, Limitations -- 3. Outcomes of Current Physician Training -- 4. Debt -- 5. Title VII Effect, Personal Interests, and Experiences in Medical School -- 6. Return on Investment -- 7. Conclusions and Recommendations -- Appendices.
  • Julia Crim.
    PrintStatus: Not Checked OutLane Catalog Record
    This illustrated reference is a practical guide to the use of arthrography in conjunction with MRI and CT for accurate diagnosis of musculoskeletal injuries and diseases. The opening general principles section includes chapters on arthrographic appearance of arthritides, basic techniques, therapeutic injections, tenosynography, and ultrasound-guided aspiration. Subsequent sections focus on the shoulder, elbow, wrist, hip, sacroiliac joint, knee, ankle, and foot. Each section includes an explanation of arthrographic procedures and pitfalls; an atlas of relevant articular anatomy; diagnostic criteria and differential diagnoses for specific injuries and diseases; and a chapter on postoperative findings. The format features succinct, bulleted text and hundreds of illustrations with detailed legends.
  • v. 1-2.From: Google Books
    Fulltext (v. 2)From: Google Books
    nach Vorlesungen bearb. von Dr. Wilhelm v. Leube ...
    Also available: Print – v. 1-2.
  • 1895-From: Google Books
    nach vorlesungen bearb. von dr. Wilhelm v. Leube ...
    Also available: Print – v. 1, 1895.
  • John S. Wilkins.
    In this comprehensive work, John S. Wilkins traces the history of the idea of "species" from antiquity to today, providing a new perspective on the relationship between philosophical and biological approaches.--[Book cover].
  • 2014From: CRCnetBASE
    edited by Kasirajan Ayyanathan, PhD.
    This new volume on gene expression and epigenetics discusses environmental effects related to specific gene expression. The book also shows methods for bioinformatic analysis of the epigenome. The book is broken into two sections: the first looks at eukaryotic DNA methylation and the second addresses how to integrate genomic medicine into clinical practice. The book includes chapters on these topics: Gene expression in colon cancer tissue Epigenetics in human acute kidney injury Embryologically relevant candidate genes in MRKH patients DNA methylation in common skeletal disorders Causal relat.
  • Linh Nguyen Pham.
    PrintStatus: Not Checked OutLane Catalog Record
  • Matthew Phil Klassen.
    PrintStatus: Not Checked OutLane Catalog Record
  • 1975-From: Google Books
    Center for Disease Control, Biological Products Division, Diagnostic Products Evaluation Branch.
    v. 1. Bacterial, fungal, parasitic.
    Also available: Print – 1975-
  • 2007From: CRCnetBASE
    edited by Daniel S. Sem.
    The systems-based approach to proteomics and chemical proteomics / Daniel S. Sem -- Similarities in protein binding sites / Hugo O. Villar, Mark R. Hansen, and Richard Kho -- Survey of spectral techniques used to study proteins / Daniel S. Sem -- Capillary electrophoresis, mass spectrometry for characterization of peptides and proteins / Christian Neusüss and Matthias Pelzing -- Protein and peptide analysis by matrix-assisted laser desorption/ionization tandem mass spectrometry (Maldi MS/MS) / Emmanuelle Sachon and Ole Nørregaard Jensen -- Characterization of glycosylated proteins by mass spectrometry using microcolumns and enzymatic digestion / Per Hägglund and Martin R. Larsen -- Surface-enhanced laser desorption/ionization protein biochip technology for proteomics research and assay development / Scot R. Weinberger ... [et al.] -- An approach to the reproducibility of SELDI profiling / Walter S. Liggett ... [et al.] -- Mass spectrometric applications in immunoproteomics / Anthony W. Purcell ... [et al.] -- Near-infrared fluorescence detection of antigen-antibody interactions on microarrays / Sakanyan Vehary and Yeretssian Garabet -- Application of shotgun proteomics to transcriptional regulatory pathways / Amber L. Mosley and Michael P. Washburn -- Electrophoretic NMR of protein mixtures and its proteomic applications / Qiuhong He, Sunitha B. Thakur, and Jeremy Spater -- Characterizing proteins and proteomes using isotope-coded mass spectrometry / Uma Kota and Michael B. Goshe -- Surface plasmon resonance biosensors’ contributions to proteome mapping / Rebecca L. Rich and David G. Myszka -- Application of in-cell NMR spectrocopy to investigation of protein behavior and ligand-protein interaction inside living cells / Volker Dötsch -- An overview of metabonomics techniques and applications / John C. Lindon, Elaine Holmes, and Jeremy K. Nicholson -- NMR-based structural proteomics / John L. Markley -- Leveraging x-ray structural information in gene family-based drug discovery: application to protein kinases / Marc Jacobs ... [et al.] -- EPR spectroscopy in genome-wide expression studies / Richard Cammack -- Summary of chapters and future prospects for spectral techniques in proteomics / Daniel S. Sem.
  • v. 1-6, 2006.From: Springer
    v. 2, 2006From: Springer
    v. 3, 2006From: Springer
    v. 4, 2006From: Springer
    v. 5, 2006From: Springer
    v. 6, 2006From: Springer
    edited by Viqar Uddin Ahmad and Anwer Basha.
    v. 1. Cholestanes, ergostanes, withanolides, stigmastane -- v. 2. Stigmastanes, furostanes, spirtostanes-- v. 3. Spirostanes, bufanolides, cardenolides-- v. 4. Cardenolides and pregnanes -- v. 5. Pregnanes, androstanes, and miscellaneous -- v. 6. Miscellaneous steroids and indexes.
  • 2012From: Springer Protocols
    edited by Wlodek M. Bujalowski.
    Fluorescence lifetime imaging comes of age how to do it and how to interpret it / Yi-Chun Chen, Bryan Q. Spring, and Robert M. Clegg -- Forster resonance energy transfer and trapping in selected systems : analysis by Monte-Carlo simulation / P. Bojarski, A. Synak, L. Kułak, S. RangeIowa-Jankowska, A. Kubicki, and B. Grobelna -- Molecular organization of polyene antibiotic amphotericin B studied by means of fluorescence technique / Wieslaw I. Gruszecki, Rafal Luchowski, Piotr Wasko, Zygmunt Gryczynski, and Ignacy Gryczynski -- Spectroscopic probes of RNA structure and dynamics / Kathleen B. Hall -- Fluorescence methods to study DNA translocation and unwinding kinetics by nucleic acid motors / Christopher J. Fischer, Eric J. Tomko, Colin G. Wu, and Timothy M. Lohman -- Fluorescence intensity, anisotropy, and transient dynamic quenching stopped-flow kinetics / Wlodek M. Bujalowski and Maria J. Jezewska -- Using structure-function constraints in FRET studies of large macromolecular complexes / Wlodek M. Bujalowski and Maria J. Jezewska -- Illuminating allostery in metal sensing transcriptional regulators / Nicholas E. Grossoehme and David P. Giedroc -- Fluorescence-based biosensors / Maria Strianese, Maria Staiano, Giuseppe Ruggiero, TullioLabella, Claudio Pellecchia, and Sabato D'Auria -- Metal-enhanced Immunoassays / Ignacy Gryczynski, Rafal Luchowski, Evgenia G. Matveeva, Tanya Shtoyko, Pabak Sarkar, Julian Borejdo, Irina Akopova, and Zygmunt Cryczynski -- Initial stages of angiosperm greening monitored by low-temperature fluorescence spectra and fluorescence lifetimes / Beata Mysliwa-Kurdziel, Anna Stecka, and Kazimierz Strzalka -- Activation of the mammalian cells by using light-sensitive ion channels / Mandy Siu Yu Lung, Paul Pilowsky, and Ewa M. Goldys -- Detection of specific strains of viable bacterial pathogens by using RNA bead assays and flow cytometry with 2100 Bioanalyzer / Philip Butterworth, Henrique T.M.C.M. Baltar, Martin Kratzmeier, and Ewa M. Goldys -- Photosynthetic antenna complex LHCII studied with novel fluorescence techniques / Wieslaw I. Gruszecki, Rafal Luchowski, Wojciech Grudzinski, Zygmunt Gryczynski, and Ignacy Gryczynski -- Analysis of RNA folding and ribonucleoprotein assembly by single-molecule fluorescence spectroscopy / Goran Pljevaljčić, Rae Robertson-Anderson, Edwin van der Schans, and David Miller -- Single-molecule force spectroscopy of polycystic kidney disease proteins / Liang Ma, Meixiang Xu, and Andres F. Oberhauser -- Single molecule detection approach to muscle study : kinetics of a single cross-bridge during contraction of Muscle / Julian Borejdo, Danuta Szczesna-Cordary, Priya Muthu, Prasad Metticolla, Rafal Luchowski, Zygmunt Gryczynski, and Ignacy Gryczynski -- Single-molecule optical-trapping measurements with DNA anchored to an array of gold nanoposts / D. Hern Paik and Thomas T. Perkins -- Electro-optical analysis of macromolecular structure and dynamics / Dietmar Porschke -- Cryoradiolysis and cryospectroscopy for studies of heme-oxygen intermediates in cytochromes P450 / I.G. Denisov, Y.V. Grinkova, and S.G. Sligar.
  • 2013From: Cambridge
    edited by Philip Hasleton and Douglas B. Flieder.
    "Fully rewritten and updated for the 6th edition. All recognized diseases of the lungs are discussed and illustrated with extensive, high-quality color images. Each chapter includes practical, clear and concise diagnostic features, including immunohistochemistry, molecular tests and differential diagnoses, while rare entities are discussed and illustrated in detail. This thoroughly reworked edition includes new classification schemes and the latest understanding of the pathophysiology and molecular aspects of a wide range of diseases. Non-neoplastic diseases are presented according to epidemiology, genetics, clinical manifestations, radiographic findings, pathology, cytology, laboratory findings, pathogenesis, differential diagnosis, prognosis and natural history. Neoplasms are discussed according to cell or origin with sections devoted to genetics, molecular findings and clinicopathologic correlations."--Provided by publisher [abridged].
  • 2016From: Springer
    Mariano G. Buffone, editor.
    Preface -- The acrosome reaction: a historical perspective -- The acrosomal matrix -- Role of ion channels in the sperm acrosome reaction -- The molecules of sperm exocytosis -- Sperm capacitation and acrosome reaction in mammalian sperm -- Lipid regulation of acrosome exocytosis -- Role of actin cytoskeleton during mammalian sperm acrosomal exocytosis -- Site of mammalian sperm acrosome reaction.
  • 2011From: Springer
    Armand Zini, Ashok Agarwal, editors.
    Sperm DNA damage is common and has been associated with reduced rates of conception, impaired embryonic development and increased risk of miscarriage. Although the exact causes of sperm DNA damage are unknown, it is clear that infertile men possess substantially higher levels of sperm DNA damage than do fertile men. Written by leading, internationally renowned clinicians and basic scientists with expertise in sperm DNA, Sperm Chromatin: Biological and Clinical Applications in Male Infertility and Assisted Reproduction provides readers with a thoughtful and comprehensive review of the biological and clinical significance of sperm DNA damage.
  • 2006From: Springer
    Todd K. Shackelford, Nicholas Pound, editors.
    No evidence for killer sperm or other selective interactions between human spermatozoa in ejaculates of different males in vitro (1999) / Harry D.M. Moore, M. Martin & Tim R. Burkhead -- Psychological adaptation to human sperm competition (2002) / Todd K. Shackelford ... [et al.] -- Semen displacement as a sperm competition strategy in humans (2004) / Gordon G. Gallup & Rebecca L. Burch -- Human female orgasm and male fluctuating asymmetry (1995) / Randy Thornhill, Steve W. Gangestad & Randall Comer. Sperm competition in humans / Nicholas Pound, Todd K. Shackelford, Aaron T. Goetz -- Why are there so many tiny sperm? Sperm competition and the maintenance of two sexes (1982) / Geoffrey A. Parker -- Sperm competition, male prudence, and sperm-limited females (2002) / Nina Wedell, Matthew J.G. Gage & Geoffrey A. Parker -- Human sperm competition (1984) / Robert L. Smith -- "Kamikaze" sperm in mammals? (1988) / R. Robin Baker & Mark A. Bellis -- Deformed sperm are probably not adaptive (1989) / Alexander H. Harcourt -- Elaboration of the kamikaze sperm hypothesis: a reply to Harcourt (1989) / R. Robin Baker & Mark A. Bellis -- Number of sperm in human ejaculates varies in accordance with sperm competition theory (1989) / R. Robin Baker & Mark A. Bellis -- Do females promote sperm competition? Data for humans (1990) / Mark A. Bellis & R. Robin Baker -- Human sperm competition: ejaculate adjustment by males and the function of masturbation (1993) / R. Robin Baker & Mark A. Bellis -- Human sperm competition: ejaculate manipulation by females and a function for the female orgasm (1993) / R. Robin Baker & Mark A. Bellis --
  • 2012From: Springer Protocols
    edited by Douglas T. Carrell, Kenneth I. Aston.
    Methods for sperm concentration determination / Lars Bjorndahl -- Methods of sperm vitality assessment / Sergey I. Moskovtsev and Clifford L. Librach -- Hypo-osmotic swelling test for evaluation of sperm membrane integrity / Sivakumar Ramu and Rajasingam S. Jeyendran -- Sperm morphology classification : a rational method for schemes adopted by the World Health Organization / Susan A. Rothmann [and others] -- Sperm morphology assessment using strict (tygerberg) criteria / Roelof Menkveld -- Methods for direct and indirect antisperm antibody testing / Hiroaki Shibahara and Junko Koriyama -- Manual methods for sperm motility assessment / David Mortimer and Sharon T. Mortimer -- Computer-aided sperm analysis (CASA) of sperm motility and hyperactivation / David Mortimer and Sharon T. Mortimer -- Hemizona assay for assessment of sperm function / Sergio Oehninger, Mahmood Morshedi, and Daniel Franken -- Sperm penetration assay for the assessment of fertilization capacity / Kathleen Hwang and Dolores J. Lamb -- Methods for the assessment of sperm capacitation and acrosome reaction excluding the sperm penetration assay / Christopher J. De Jonge and Christopher L.R. Barratt -- Sperm DNA fragmentation analysis using the TUNEL assay / Rakesh Sharma, Jayson Masaki, and Ashok Agarwal -- Sperm DNA damage measured by comet assay / Luke Simon and Douglas T. Carrell -- Sperm chromatin structure assay (SCSA) / Donald P. Evenson -- Sperm aneuploidy testing using fluorescence in situ hybridization / Benjamin R. Emery -- Flow cytometric methods for sperm assessment / Vanesa Robles and Felipe Martinez-Pastor -- Human y chromosome microdeletion analysis by PCR multiplex protocols identifying only clinically relevant AZF microdeletions / Peter H. Vogt and Ulrike Bender -- Sperm cryopreservation methods / Tiffany Justice and Greg Christensen -- Density gradient separation of sperm for artificial insemination / David Mortimer and Sharon T. Mortimer -- Recovery, isolation, identification, and preparation of spermatozoa from human testis / Charles H. Muller and Erin R. Pagel -- Enhancement of sperm motility using pentoxifylline and platelet-activating factor / Shilo L. Archer and William E. Roudebush -- Intracytoplasmic morphology-selected sperm injection / Luke Simon, Aaron Wilcox, and Douglas T. Carrell -- Sperm selection for ICSI using annexin V / Sonja Grunewald and Uwe Paasch -- Sperm selection for ICSI using the hyaluronic acid binding assay / Mohammad Hossein Nasr-Esfahani and Tavalaee Marziyeh -- sperm selection based on electrostatic charge / Luke Simon, Shao-qin Ge, and Douglas T. Carrell -- Sex-sorting sperm using flow cytometry/cell sorting / Duane L. Garner, K. Michael Evans, and George E. Seidel -- Assessment of spermatogenesis through staging of seminiferous tubules / Marvin L. Meistrich and Rex A. Hess -- Immunohistochemical approaches for the study of spermatogenesis / Cathryn A. Hogarth and Michael D. Griswold -- Ultrastructural analysis of testicular tissue and sperm by transmission and scanning electron microscopy / Hector E. Chemes -- Assessment of oxidative stress in sperm and semen / Anthony H. Kashou, Rakesh Sharma, and Ashok Agarwal -- Improved chemiluminescence assay for measuring antioxidant capacity of seminal plasma / Charles H. Muller, Tiffany K.Y. Lee, and Michalina A. Montano -- Methods of sperm DNA extraction for genetic and epigenetic studies / Jeanine Griffin -- Isolating mRNA and small noncoding RNAs from human sperm / Robert J. Goodrich, Ester Anton, and Stephen A. Krawetz -- Review of genome-wide approaches to study the genetic basis for spermatogenic defects / Kenneth I. Aston and Donald F. Conrad -- Methods for the analysis of the sperm proteome / Sara de Mateo, Josep Maria Estanyol, and Rafael Oliva -- Methodology of aniline blue staining of chromatin and the assessment of the associated nuclear and cytoplasmic attributes in human sperm / Leyla Sati and Gabor Huszar -- Isolation of sperm nuclei and nuclear matrices from the mouse, and other Rodents / W. Steven Ward -- Protamine extraction and analysis of human sperm protamine 1/protamine 2 ratio using acid gel electrophoresis / Lihua Liu, Kenneth I. Aston, and Douglas T. Carrell -- Analysis of gene-specific and genome-wide sperm DNA methylation / Saher Sue Hammoud, Bradley R. Cairns, and Douglas T. Carrell -- Evaluating the localization and DNA binding complexity of histones in mature sperm / David Miller and Agnieszka Paradowska -- In vitro spermatogenesis using an organ culture technique / Tetsuhiro Yokonishi [and others] -- Testicular tissue grafting and male germ cell transplantation / Jose R. Rodriguez-Sosa, Lin Tang, and Ina Dobrinski -- Transgenic modification of spermatogonial stem cells using lentiviral vectors / Christina Tenenhaus Dann -- Methods for sperm-mediated gene transfer / Marialuisa Lavitrano, Roberto Giovannoni, and Maria Grazia Cerrito -- Phenotypic sssessment of male fertility status in transgenic animal models / David M. de Kretser and Liza O'Donnell.
  • 1911-From: Google Books
    nach Vorlesungen bearbeitet von Wilhelm v. Leube.
    Also available: Print – v. 1.
  • 2006From: Springer
    Y. Hirabayashi, Y. Igarashi, A.H. Merrill, Jr., (eds.).
  • 2013From: Springer
    Erich Gulbins, Irina Petrache, editors.
    Sphingolipids are lipid components of the plasma membrane in eukaryotic cells. They have an important function in signaling mechanisms in the cell. This book on sphingolipids provides insights into the basics of sphingolipid biology and drug development, with a particular emphasis on the sphingolipid derivative ceramide. In the first part basic functions of sphingolipids are described, as well as the genetics of important enzymes, sphingolipid metabolism and synthesis. The second part of this first volume focuses on drug development and pharmacology. The book is intended for scientists in pharmacology, biochemistry and cell biology with a focus on biomedical research as well as for clinicians working in pharmacology, oncology, cardiology, neurology and infectious disease. Together with Volume 216 by the same editors, the collection represents a unique, comprehensive work on sphingolipids, providing information on both sphingolipids' basic biology (including synthesis, metabolism and cell biology) and their important function in a (patho-)physiological context.
  • 2011From: Springer
    edited by L. Ashley Cowart.
    Sphingolipid metabolism and analysis in metabolic disease / Sarah E. Brice and L. Ashley Cowart -- Sphingolipids and cardiovascular diseases : lipoprotein metabolism, atherosclerosis and cardiomyopathy / Xian Cheng Jiang, Ira J. Goldberg, and Tae Sik Park -- Heart sphingolipids in health and disease / Marcin Baranowski and Jan Grski -- Blood sphingolipids in homeostasis and pathobiology / Samar M. Hammad -- Adipose tissue and ceramide biosynthesis in the pathogenesis of obesity / Fahumiya Samad ... [et al.] -- Sphingolipids and hepatic steatosis / Benjamin T. Bikman and Scott A. Summers -- Glycosphingolipids and insulin resistance / Johannes M. Aerts ... [et al.] -- Glycosphingolipids and kidney disease / Andrew R. Mather and Leah J. Siskind -- Sphingolipid synthetic pathways are major regulators of lipid homeostasis / Tilla S. Worgall.
    Also available: Print – 2011
  • 2010From: Springer
    edited by Charles Chalfant, Maurizio Del Poeta.
    An overview of sphingolipid metabolism : from synthesis to breakdown / Christopher R. Gault, Lina M. Obeid, and Yusuf A. Hannun -- Sphingolipid transport / Laura Riboni, Paola Giussani and Paola Viani -- Sphingolipid analysis by high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) / Jacek Bielawski ... [et al.] -- Ceramide synthases : roles in cell physiology and signaling / Johnny Stiban, Rotem Tidhar and Anthony H. Futerman -- Tales and mysteries of the enigmatic sphingomyelin synthase family / Joost C.M. Holthuis and Chiara Luberto -- Ceramide in stress response / Mariana N. Nikolova-Karakashian and Krassimira A. Rozenova -- Animal models for studying the pathophysiology of ceramide / Toshihiko Kawamori -- Ceramide 1-phosphate in cell survival and inflammatory signaling / Antonio Gómez-Muñoz ... [et al.] -- Ceramide-1-phosphate in phagocytosis and calcium homeostasis / Vania Hinkovska-Galcheva and James A. Shayman -- Extracellular and intracellular actions of sphingosine-1-phosphate / Graham M. Strub ... [et al.] -- Glucosylceramide in humans / Maria C. Messner and Myles C. Cabot -- Gangliosides as regulators of cell membrane organization and functions / Sandro Sonnino and Alessandro Prinetti -- Cancer treatment strategies targeting sphingolipid metabolism / Babak Oskouian and Julie D. Saba -- Therapeutic strategies for diabetes and complications : a role for sphingolipids? / Todd E. Fox and Mark Kester -- Roles for sphingolipids in Saccharomyces cerevisiae / Robert C. Dickson -- Sphingolipid signaling in fungal pathogens / Ryan Rhome and Maurizio Del Poeta -- Sphingolipids in parasitic protozoa / Kai Zhang, James D. Bangs and Stephen M. Beverley -- Biosynthesis of sphingolipids in plants (and some of their functions) / Simone Zäuner, Philipp Ternes, and Dirk Warnecke -- Computational analysis of sphingolipid pathway systems / Eberhard O. Voit, Fernando Alvarez-Vasquez, and Yusuf A. Hannun.
    Also available: Print – 2010
  • 2013From: Springer
    Erich Gulbins, Irina Petrache, editors.
    Sphingolipids in Cancer. Sphingosine Kinase/Sphingosine 1-Phosphate Signaling in Cancer Therapeutics and Drug Resistance / Shanmugam Panneer Selvam, Besim Ogretmen -- Using ASMase Knockout Mice to Model Human Diseases / Guoqiang Hua, Richard Kolesnick -- New Perspectives on the Role of Sphingosine 1-Phosphate in Cancer / Susan Pyne, Nigel J. Pyne -- Sphingolipids and Response to Chemotherapy / Marie-Thérèse Dimanche-Boitrel, Amélie Rebillard -- Lung Cancer and Lung Injury: The Dual Role of Ceramide / Tzipora Goldkorn, Samuel Chung, Simone Filosto -- Sphingolipids' Role in Radiotherapy for Prostate Cancer / Carla Hajj, Adriana Haimovitz-Friedman -- Sphingolipids in Cardio-Reno-vascular Diseases. Sphingolipid Metabolism and Atherosclerosis / Xian-Cheng Jiang, Jing Liu -- Cardiovascular Effects of Sphingosine-1-Phosphate (S1P) / Bodo Levkau -- Cross Talk Between Ceramide and Redox Signaling: Implications for Endothelial Dysfunction and Renal Disease / Pin-Lan Li, Yang Zhang -- Sphingolipids in Inflammation, Infection and Lung Diseases. Sphingolipids in Lung Endothelial Biology and Regulation of Vascular Integrity / Taimur Abbasi, Joe G. N. Garcia -- Sphingolipids in Acute Lung Injury / Stefan Uhlig, Yang Yang -- The Involvement of Sphingolipids in Chronic Obstructive Pulmonary Diseases / Irina Petrache, Daniela N. Petrusca -- Ceramide in Cystic Fibrosis / Heike Grassmé, Joachim Riethmüller, Erich Gulbins -- Regulation of the Sphingosine Kinase/Sphingosine 1-Phosphate Pathway / K. Alexa Orr Gandy, Lina M. Obeid -- Bacterial Infections and Ceramide / Heike Grassmé, Katrin Anne Becker -- Viral Infections and Sphingolipids / Jürgen Schneider-Schaulies, Sibylle Schneider-Schaulies -- Ceramide in Plasma Membrane Repair / Annette Draeger, Eduard B. Babiychuk -- Sphingolipids and Inflammatory Diseases of the Skin / Burkhard Kleuser, Lukasz Japtok -- Sphingolipids in Obesity, Type 2 Diabetes, and Metabolic Disease / S. B. Russo, J. S. Ross, L. A. Cowart -- Sphingolipids in Neuro-psychiatry and Muscle Diseases. Neuronal Forms of Gaucher Disease / Einat B. Vitner, Anthony H. Futerman Sphingolipids in Neuroinflammation / Laura Davies, Klaus Fassbender, Silke Walter -- Sphingolipids in Psychiatric Disorders and Pain Syndromes / C. Mühle, M. Reichel, E. Gulbins, J. Kornhuber -- Role of Sphingosine 1-Phosphate in Skeletal Muscle Cell Biology / Paola Bruni, Chiara Donati.
  • 2012From: Springer Protocols
    edited by Alice Pébay, Kursad Turksen.
    Biochemical methods for quantifying sphingolipids : ceramide, sphingosine, sphingosine kinase-1 activity, and sphingosine-1-phosphate / Leyre Brizuela and Olivier Cuvillier -- Isoform-selective assays for sphingosine kinase activity / Melissa R. Pitman, Duyen H. Pham, and Stuart M. Pitson -- Quantification of sphingosine-1-phosphate and related sphingolipids by liquid chromatography coupled to tandem mass spectrometry / Constantin Bode and Markus H. Gräler -- Cleanup method for mass spectrometry of sphingosine-1-phosphate in blood and solid tissues using a phosphate capture molecule / Jun-ichi Morishige, Tamotsu Tanaka, and Kiyoshi Satouchi -- Immunohistochemical detection of sphingosine-1-phosphate and sphingosine kinase-1 in human tissue samples / Barbara Visentin, Gary Reynolds, and Roger Sabbadini -- Assessment of sphingosine-1-phosphate activity in biological samples by receptor internalization and adherens junction formation / Hideru Obinata and Timothy Hla -- High-throughput assays to measure intracellular Ca2+ mobilization in cells that express recombinant S1P receptor subtypes / William J. Valentine and Gabor Tigyi -- Quantifying sphingosine-1-phosphate-dependent activation of the RhoGTPases / Matt D. Medlin, Joan M. Taylor, and Christopher P. Mack -- Optimized protocols to analyze sphingosine-1-phosphate signal transduction pathways during acrosomal exocytosis in human sperm / Silvia A. Belmonte and Laila Suhaiman -- Use of intravital microscopy and in vitro chemotaxis assays to study the roles of sphingosine-1-phosphate in bone homeostasis / Taeko Ishii [and others] -- Assessment of sphingosine-1-phosphate receptor expression and associated intracellular signaling cascades in primary cells of the human central nervous system / Veronique E. Miron [and others] -- Sphingosine-1-phosphate signaling in skeletal muscle cells / Elisabetta Meacci, Francesca Bini, and Chiara Battistini -- Maintenance of human embryonic stem cells by sphingosine-1-phosphate and platelet-derived growth factor / Raymond C.B. Wong, Martin F. Pera, and Alice Pébay -- Ceramide and sphingosine-1-phosphate signaling in embryonic stem cell differentiation / Erhard Bieberich -- Sphingosine-1-phosphate signaling in neural progenitors / Phillip Callihan and Shelley B. Hooks -- Utilizing sphingosine-1-phosphate to stimulate sprouting angiogenesis / Shih-Chi Su and Kayla J. Bayless.
  • 2014From: Springer
    Michael B.A. Oldstone, Hugh Rosen, editors.
    "This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses."--Publisher's website.
    Also available: Print – 2014
  • 2016From: Springer
    Luigi Manfrè, editor.
    Imaging -- Biomechanics -- Symptoms -- CT/X-ray guided technique in lumbar spinal canal stenosis: Spacers -- CT/X-ray guided technique in lumbar spinal canal stenosis: MILD -- CT/X-ray guided technique in lumbar foramina stenosis.
  • 2013From: ScienceDirect
    edited by Paul W. Hodges, Jacek Cholewicki, Jaap H. van Dieën.
    Spine systems science : a primer on the systems approach / N. Peter Reeves, Jacek Cholewicki -- Computational models for trunk trajectory planning and load distribution : a test-bed for studying various clinical adaptation and motor control strategies of low back pain patients / Mohamad Parnianpour -- Mechanical changes in the spine in back pain / Greg Kawchuk -- Spine function and low-back pain : interactions of active and passive structures / Jaap H. van Dieen, Idsart Kingma -- Adaptation and rehabilitation: from motoneurones to motor cortex and -- Behaviour / Paul W. Hodges -- Opinions on the links between back pain and motor control : the disconnect -- Between clinical practice and research / Stuart McGill -- The kinesiopathologic model and mechanical low back pain / Linda R. Van Dillen, Shirley A. Sahrmann, Barbara J. Norton -- The relationship between control of the spine and low back pain : a clinical -- Researcher's perspective / Julie A. Hides -- Existing muscle synergies and low back pain : a case for preventative -- Intervention / Jack P. Callaghan, Erika Nelson-Wong -- Trunk muscle control and back pain : chicken, egg, neither or both? / G. Lorimer Moseley -- Altered variability in proprioceptive postural strategy in people with recurrent low back pain / Simon Brumagne ... [et al.] -- Proprioceptive contributions from paraspinal muscle spindles to the relationship between control of the trunk and back pain / Joel G. Pickar -- Time-dependent mechanisms that impair muscle protection of the spine / Patricia Dolan, Michael A. Adams -- Effectiveness of exercise therapy for chronic non-specific low-back pain / Marienke van Middelkoop .... [et al.] -- How can models of motor control be useful for understanding low back pain? (summary chapter 1) / N. Peter Reeves ... [et al.] -- Targeting interventions to patients : development and evaluation (summary chapter 2) / Linda van Dillen, Maurits van Tulder -- Motor control changes and low-back pain, cause or effect? (summary chapter 3) / Jaap H. van Dieen, G. Lorimer Moseley, Paul W. Hodges -- What is the relation between proprioception and low back pain? (summary chapter 4) / Simon Brumagne, Patricia Dolan, Joel G. Pickar -- Motor control of the spine and changes in pain : debate about the extrapolation from research observations of motor control strategies to effective treatments for back pain (summary chapter 5) / Paul W. Hodges, Stuart McGill, Julie A. Hides -- Integrated clinical approach to motor control interventions in low back and pelvic pain / Paul W. Hodges ... [et al.].
  • 2009From: ScienceDirect
    editors, Charles Watson, George Paxinos, Gulgun Kayalioglu.
    The organization of the spinal cord / Charles Watson and Gulgun Kayalioglu -- Development of the spinal cord / Kens WS Ashwell -- The vertebral column and spinal meninges / Gulgun Kayalioglu -- The spinal nerves / Gulgun Kayalioglu -- The spinal cord blood vessels / Oscar U. Scremin -- Cytoarchitecture of the spinal cord / Claire Heise and Gulgun Kayalioglu -- Localization of motoneurons in the spinal cord / Steve McHanwell and Charles Watson -- Spinal autonomic preganglionic neurons: the visceral efferent system of the spinal cord / Colin R. Anderson, Janet R. Keast and Elspeth M. McLachlan -- Central nervous system control of micturition / Gert Holstege and Han Collewijn -- Projections from the spinal cord to the brain / Gulgun Kayalioglu -- Projections from the brain to the spinal cord / Charles Watson and Alan R. Harvey -- The propriospinal system / Amanda C. Conta and Dennis J. Stelzner -- Spinal cord transmitter substances / Claire Heise and Gulgun Kayalioglu -- Spinal cord injury: experimental animal models and relation to human therapy / Stuart I. Hodgetts, Giles W. Plant and Alan R. Harvey -- Atlas of the rat spinal cord / Charles Watson ... [et al.] -- Atlas of the mouse spinal cord / Charles Watson ... [et al.] -- Toward a spinal cord ontology / Charles Watson and Amandeep Sidhu.
  • 2006From: Thieme eNeurosurgery
    [edited by] Curtis A. Dickman, Michael G. Fehlings, Ziya L. Gokaslan.
    Presents authorataive coverage of state-of-the-art techniques for diagnosing and managing tumors of the spine and spinal cord. Covers fundamentals of spinal cord anatomy and the pathology of spinal tumors to evaluation, diagnosis, and treatment techniques for specific spinal tumors.
  • 2012From: ScienceDirect
    edited by Joost Verhaagen and John W. McDonald.
    Spinal Cord Injuries, the newest volume in the Handbook of Clinical Neurology series, offers a comprehensive and detailed overview of the rapidly evolving science and treatment of spinal cord injury. Advances in neuroimaging, surgical treatment and application of electrical stimulation are dramatically impacting the treatment and outcome of these injuries. It provides a clear introduction to the core science of spinal cord injury, as well as to exciting research investigating new treatment options. Coverage includes brain-machine interfaces, transcranial stimulation, new pharmacological strategies, use of olfactory ensheathing cells, stem cells and precursor cells, gene therapy and molecular target discovery. This volume is a great resource for neuroscience and clinical neurology research specialists and practicing neurologists seeking a clear reference to the science and treatment of spinal cord injury. Comprehensive coverage of the latest scientific understanding of spinal cord injuries Detailed coverage of current treatment best practices and potential future treatments Connects leading edge research programs to future treatment opportunities .
  • 1965-66, 1972, 1977From: Google Books
    Fulltext (1966)From: Google Books
    Fulltext (1972)From: Google Books
    Fulltext (1977)From: Google Books
  • 2002From: ScienceDirect
    edited by L. McKerracher, G. Doucet, S. Rossignol.
    Section I. Spinal cord injuries in patients -- Section II. Spinal cord injuries in animal models -- Section III. Neuroprotection and transplantation -- Section IV. Molecular targets to promote axon regeneration in the CNS.
    Also available: Print – 2002
  • 2014From: Thieme eNeurosurgery
    [edited by] Robert F. Heary, Todd J. Albert.
    1. The History and Overview of Spinal Deformity -- 2. Measuring Value in Spinal Deformity Care -- 3. Intraoperative Neuromonitoring in Spinal Deformity Surgery -- 4. Anatomy and Evaluation of Spinal Alignment -- 5. Anatomical Variants with Spinal Deformity -- 6. The Importance of the Sacrum and Pelvis in Deformity Evaluation and Treatment -- 7. The Lenke Classification System for Adolescent Idiopathic Scoliosis -- 8. Principles of Sagittal Plane Deformity -- 9. Principles of Coronal Plane Deformity -- 10. Flexible versus Fixed Spinal Deformity -- 11. The Natural History of Spinal Deformity -- 12. Congenital Scoliosis -- 13. Early-Onset Scoliosis -- 14. Neuromuscular Scoliosis -- 15. Anterior Surgery for Thoracic Scoliosis -- 16. Posterior Approach in Thoracic Deformity -- 17. Lateral Interbody Fusion Approaches in Spinal Deformity -- 18. Anterior-Posterior Surgery for Spinal Deformity -- 19. Minimally Invasive Surgery for Adult Spinal Deformities -- 20. Scheuermann Kyphosis -- 21. Technological Advances in Spinal Deformity -- 22. Surgery for Adult Spinal Deformity -- 23. Osteotomies and Vertebral Column Resections for Complex Spinal Deformities -- 24. Adult Spinal Deformity Revision Surgery -- 25. Surgical Treatment of Spondylolisthesis -- 26. Prevention and Treatment of Posttraumatic Deformity of the Thoracolumbar Spine -- 27. Bracing and Nonoperative Treatment of Spinal Deformity.
  • 2008From: Thieme Book
    [edited by] Herwig Imhof ; with contributions by Benjamin Halpern, Andreas M. Herneth, Klaus M. Friedrich, Michael Matzner, Christina Mueller-Mang, Iris-Melanie Noebauer-Huhmann, Daniela Prayer, Oliver Sommer, Florian Wolf ; translator: John Grossman ; illustrator, Emil Wolfgang Hanns.
    1. Congenital malformations -- Arnold-Chiari malformation -- Lumbarization and sacralization -- Diastematomyelia -- Tethering -- Sacrococcygeal teratoma -- Meningocele, myelomeningocele -- Vertebral malformations -- Klippel-Feil syndrome -- Kyphosis -- Scheuermann disease -- Scoliosis -- Malrotation -- 2. Trauma -- Spinal injury-magerl classification -- Vertebral fractures-causes -- Dens fracture -- Flexion fracture of the cervical spine -- Burst fracture of the spine -- Chance fracture (seat belt fracture) -- Jefferson fracture -- Hangmans's fracture -- Spinal cord trauma -- Syringohydromyelia -- Anterior subluxation -- Insufficiency fracture of the sacrum -- Stress phenomena in the spine -- Stress fractures in ankylosing spondylitis -- 3. Degenerative disorders -- Disk degeneration -- Degenerative disk disease modic I -- Degenerative disk disease modic II -- Spondylosis deformans-modic III -- Disk herniation -- Bulge, protrusion, extrusion, sequestration -- Disk calcification and vacuum phenomenon -- Facet joint degeneration -- Uncovertebral osteoarthritis -- Synovial cyst -- Hypertroply of the ligamenta flava -- Baastrup disease -- Spongylolisthesis and pseudospondylolisthesis -- Degenerative spinal stenosis -- Diffuse idiopathic skeletal hyperostosis -- 4. Inflammatory disorders -- Rheumatoid arthritis -- Rheumatoid arthritis-chronic trauma -- Psoriatic spondyloarthropathy -- Reiter syndrome -- Ankylosing spondylarthropathy -- Ankylosing spondylitis-ligament calcification and bamboo spine -- Ankylosing psondylitis-fractures --Acute bacterial spondylitis -- Tuberculous spondylitis -- Epidural abscess -- Granulomatous inflammations of the spinal cord -- Arachnoiditis -- Acute transverse myelitis -- Spinal Multiple sclerosis --; 5. Tumors -- Hemangioma -- Osteoid osteoma -- Osteoblastoma -- Osteochondroma -- Aneurysmal bone cyst -- Giant cell tumor -- Langerhans cell histiocytosis -- Malignant tumors -- Bone metastases -- Multiple myeloma -- Chordoma -- Ewing sarcoma -- Lymphoma -- Nerve sheath tumors -- Leptomeningeal and intramedullary metastases -- Meningioma -- Ependymoma -- Astrocytoma -- Hemangioblastoma -- 6. Vascular disorders -- Epidural hematoma -- Arteriovenous malformation -- Arterial spinal cord infarction -- 7. Postoperative disorders -- Failed back surgery syndrome -- CSF fistula -- Peridural fibrosis -- Rapidly progressive osteoarthritis (after intersegmental fusion) -- Complications of spinal instrumentation -- 8. Metabolic disorders -- Senile and postmenopausal osteoporosis -- Paget disease -- Spinal epidural lipomatosis.
  • 2007From: Springer
    J.W.M. Van Goethem, L. van den Hauwe, P.M. Parizel (eds.) ; with contributions by P.R. Algra ... [et al.] ; foreword by A.L. Baert.
  • 2009From: Thieme eNeurosurgery
    Theodoros Theodoridis, Juergen Kraemer [editors].
    1. Basic principles -- 2. Diagnostics -- 3. Causal orthopedic pain therapy -- 4. Symptomatic pain therapy -- 5. The spine : anatomy, nociception, and the distribution of pain signals -- 6. Special orthopedic injection therapy : contraindications and patient information -- 7. Cervical injection therapy -- 8. Thoracic injection therapy -- 9. Lumbar injection therapy -- 10. General and specific complications and treatment measures -- 11. Multimodal spinal therapy -- 12. Summary.
  • 2012From: ClinicalKey
    volume editors, Marc A. Huntoon, Honorio T. Benzon, Samer Narouze ; video editor, Samer Narouze.
    Sect. I. General considerations. 1. History of spine injections / Sheryl L. Johnson and Kevin E. Vorenkamp -- 2. Therapeutic agents for spine injection: local anesthetics, steroids, and contrast media / Matthew J. Pingree and Marc A. Huntoon -- 3. Fluoroscopy, ultrasonography, computed tomography, and radiation safety / Stanley Golovac -- Sect. II. Peripheral nerve blocks. 4. Differential diagnostic nerve blocks / Jerald Garcia, I. Elias Veizi, and Salim M. Hayek -- 5. Head and neck blocks / Samer Narouze -- 6. Upper extremity peripheral nerve blockade / Hugh M. Smith and Christopher M. Duncan -- 7. Lower limb blacks / Padraig Mahon and Colin J.L. McCartney -- 8. Cervical and lumbar sympathetic blocks / Samer Narouze and Sean Graham -- 9. Nerve destruction for the alleviation of visceral pain / Kacey A. Montgomery and Robert W. Hurley -- 10. Peripheral applications of ultrasonography for chronic pain / Philip Peng -- Sect. III. Injections for back pain. 11. Therapeutic epidural injections: interlaminar and transoraminal / Marc A. Huntoon and Abram H. Burgher -- 12. Facet (zygapophyseal) intraarticular joint injections: cervical, lumbar, and thoracic / Jason E. Pope and Jianguo Cheng -- 13. Medial branch blocks: cervical, thoracic, and lumbar / Seth A. Waldman, Vinita Parikh, and Dawood Sayed -- 14. Radiofrequency rizotomy for facet syndrome / Jan van Zundert ... [et al.] -- 15. Sacroiliac joint injections and lateral branch blocks, including water-cooled neurotomy / Bryan S. Williams -- 16. Pulsed radiofrequency / Khalid Malik and Honorio T. Benzon -- 17. Discogenic pain and discography for spinal injections / Stanley Golovac -- 18. Minimally invasive intradiscal procedures for the treatment of discogenic lower back and leg pain / Leonardo Kapural and Dawn A. Sparks -- 19. Vertebral augmentation / Tristan C. Pico, Basem Hamid, and Allen W. Burton -- 20. Ultrasound-guided lumbar spine injections / Manfred Greher -- 21. Ultrasound-guided cervical spine injections / Samer Narouze -- 22. Musculoskeletal injections: iliopsoas, quadratus lumborum, piriformis, and trigger point injections / Anne Marie McKenzie-Brown, Kiran Chekka, and Honorio T. Benzon -- 23. Ultrasound-guided and fluoroscopically guided joint injections / Steve J. Wisniewski and Mark-Friedrich B. Hurdle.
  • 2014From: Springer
    Lyle Micheli, Cynthia Stein, Michael O'Brien, Pierre d'Hemecourt, editors.
    Spinal Injuries and Conditions in Young Athletes provides a comprehensive, in-depth review of the mechanisms and management of back injuries and problems occurring in this ever-growing and active population. Led by Dr. Lyle Micheli and his co-editors, an award-winning group of orthopedists discusses and explores common adolescent spine injuries and procedures, in addition to breakthroughs in gene therapy, tissue engineering, and complex operations. As spine surgery is among the most complex and challenging procedures performed in orthopedics, special considerations and procedures are required in pediatric populations. Since many corrective surgeries run the risk of arthritis later in life, particular efforts must be made in young populations to prevent future injury in a child's adolescence and young adulthood while maximizing return-to-play potential. Chapters cover acute spinal injuries, concussions, overuse injuries, spinal malformations, tumors, infections and inflammatory diseases across the range of athletics, including swimming and combat sports. Spinal Injuries and Conditions in Young Athletes provides an immeasurable guide for back surgery in pediatric populations and will be a go-to resource for practitioners and residents in pediatric orthopedics and sports medicine.
  • 2015From: Springer
    Luigi Manfrè, editor.
    This easy-to-consult guide describes new minimally invasive procedures for the treatment of spinal instability that are accompanied by fewer complications and side-effects, reduce the risks of anesthesia, and lower costs. Clear accounts of a range of CT, X-ray, and MRI guided techniques are provided, including radiofrequency ablation in facet syndrome, cervical spine fusion, posterior and anterior lumbar spine fusion, and lumbosacral fusion. A brief but comprehensive introduction is included on biomechanics, relevant clinical syndromes, and diagnostic imaging. Like other books in the Springer series New Procedures in Spinal Interventional Neuroradiology, this practice-oriented volume will fill a significant gap in the literature and meet the need expressed by a large number of specialists (interventional neuroradiologists and radiologists, neurosurgeons, and orthopedists) for a topical and handy guide that specifically illustrates the presently available materials and methods.
  • 2015From: Springer
    Yan Wang, Oheneba Boachie-Adjei, Lawrence Lenke, editors.
    Spinal osteotomy techniques have been dramatically applied as a standard method for severe and rigid spinal deformity. Although clinical results indicate that patients who undergo osteotomy procedures typically experience well deformity correction and ameliorate the clinical appearance, aggressive peri-operative risks and follow-up complications are not rare. More meticulous and standard indication selection, osteotomy plan design and complication prevention strategy and outcome evaluation are critically needed for surgeon majored in spine deformity. The book Spinal Osteotomy is divided into sections that focus on principles of spinal osteotomy, technical and case illustration and outcomes and complications as well as computer navigation and other latest techniques. Each section is heavily illustrated and clearly written for ease of understanding. Orthopedic surgeons, neurosurgeon residents and fellows who want to focus on spinal deformity correction will find this instructive and invaluable. Editor Yan Wang is a professor and dean of orthopedics department, Chinese PLA general hospital, China. Oheneba Boachie-Adjei, MD, is Chief of the Scoliosis Service, Hospital for Special Surgery, New York, NY, USA. Lawrence G. Lenke MD, is Professor and Chief of the Department of Orthopedic Surgery, Washington University School of Medicine, St. Louis, MO, USA.
  • 2006From: Thieme Book
    [edited by] Victor N. Cassar-Pullicino, Herwig Imhof ; with contributions by R. Bodley [and others].
    Offers information needed to maximize the potential of ultrasound in daily practice. Topics include nephrology, urology, the urogenital tract in the child, non-ultrasound imaging of the urogenital tract, oncological management of tumors of the urogenital tract, and more.
  • 2007From: Ovid
    [edited by] Eric D. Schwartz, Adam E. Flanders.
    Pathophysiology of spinal cord injury / B. Timothy Himes -- The neurological evaluation and medical management of acute spinal cord injury / Anthony S. Burns and Ralph J. Marino -- Surgical treatment of spinal injury / Daniel R. Fassett and James S. Harrop -- Controversies in clearing the spine / C. Craig Blackmore and Ken F. Linnau -- Plain film radiography and computed tomography of the cervical spine. Part I. Normal anatomy and spinal injury identification / Alejandro Zuluaga Santamaria and Diego B. Núñez, Jr. -- Plain film radiography and computed tomography of the cervical spine. Part II. Classification and subtypes of spinal injury / Alejandro Zuluaga Santamaria and Diego B. Núñez, Jr. -- Imaging of thoracolumbar spinal injury / George Koulouris, Amy Y.I. Ting, and William B. Morrison -- Magnetic resonance imaging of acute spinal trauma / Adam E. Flanders -- Imaging of pediatric spinal trauma / Avrum N. Pollock and Stephen M. Henesch -- Postoperative spinal imaging / Ashwini D. Sharan, Hana Choe, and Laura Snyder -- Imaging of the previously injured spinal cord / Steven Falcone -- Experimental therapies for spinal cord injury / Marion Murray -- Experimental techniques of spinal imaging / Eric D. Schwartz.
  • 2011From: Thieme eNeurosurgery
    [edited by] Alexander R. Vaccaro, Michael G. Fehlings, Marcel F. Dvorak.
    Evidence-based medicine: outcomes assessment -- Fundamental principles and clinical assessment -- Imaging -- Problem-based approach to the principles of spinal injury management -- Upper cervical injuries and their management -- Subaxial cervical spine injuries and their management -- Thoracolumbar spine injuries and their management -- Rehabilitation following spinal injury and late complications -- Emerging techniques and translational research
  • 2009From: Thieme eNeurosurgery
    [edited by] Jens R. Chapman, Joseph R. Dettori, Daniel C. Norvell.
    1. Spine classification systems to spine disease severity measures : a paradigm shift -- 2. Method for identifying and evaluating spine severity measures -- 3. What makes a quality severity measure? -- 4. How the severity measures are displayed in this book -- 5. Spine disease severity measures -- 6. Spine trauma severity measures -- 7. Going beyond classification systems : new horizons for adolescent idiopathic scoliosis.
  • 2016From: Oxford Medicine Online
    edited by Shivani Gupta, Daniel M. Sciubba, Mark M. Mikhael, Savvas Nicolaou.
    This volume features multi-modality imaging studies and management guidance of spine pathologies for the consulting radiologist as well as the neurologist, orthopedist, or emergency clinician diagnosing and managing spinal patients.
  • Brian C. Bowen, Alfonso Rivera, Efrat Saraf-Lavi.
    PrintStatus: Not Checked OutLane Catalog Record
  • Efrat Saraf-Lavi.
  • Bowen, Brian C.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007From: Thieme eNeurosurgery
    Jens R. Chapman, Beate P. Hanson, Joseph R. Dettori, Daniel C. Norvell.
    Outcomes instruments that attempt to assess the function and quality of life in patients suffering from various spine conditions are on the increase. This book sets out to evaluate and summarize over 100 outcomes instruments for the spine and its associated diseases.
  • 2015From: Thieme-Connect
    [edited by] Peter C. Gerszten, Samuel Ryu.
    Radiobiology of radiosurgery / Jae Ho Kim and Stephen Brown -- Clinical spinal cord tolerance to radiosurgery / Simon S. Lo [and 10 others] -- Management of spinal cord toxicity / Samuel Ryu, Steve Brown, and Jae Ho Kim -- Histopathologic examination of spinal lesions after radiosurgery / Nathan T. Zwagerman [and 6 others] -- Stereotactic spine radiotherapy : image guidance and patient immobilization / Max Dahele and Ben Slotman -- Treatment planning for spine radiosurgery / David Schlesinger, K. Martin Richardson, Kelly M. Spencer, Brian Winey, and Jason Sheehan -- Quality assurance and treatment delivery / Fang-fang Yin, Zheng Chang, and Justus Adamson -- Contemporary devices for spinal radiosurgery / Christoph Fürweger [and 5 others] -- Imaging, target delineation, and dose prescription / Eric Chang, Omar Ragab, Sukhjeet Batth, Shelly Bian, and Lydia Nng -- Radiosurgery for the re-treatment of progressive spine metastases / Andrew A. Kanner and Benjamin W. Corn -- Clinical outcomes after spinal radiosurgery / Peter C. Gerszten and John C. Flickinger -- Clinical outcomes of pain and quality of life after spinal radiosurgery / Lily Angelov, Sam Chao, and John Suh -- Radiosurgery for spinal canal compromise and spinal cord compression / Richard A. Rammo, Ian Y. Lee, Jack P. Rock, and Samuel Ryu -- Postoperative radiosurgery and minimally invasive surgical techniques / Tobias A. Mattei [and 7 others] -- Radiosurgery and percutaneous cement augmentation / Michael Decuypere and Jason A. Weaver -- Treatment failure, complications, and their management / Nicolaus Andratschke and Matthias Guckenberger -- Patient evaluation and treatment selection for spinal canal compromise / Samuel Ryu and Mark Bilsky -- Radiosurgery for benign extramedullary tumors of the spine / Iris C. Gibbs, Navjot Chaudhary, Steven D. Chang, Robert L. Dodd, and John R. Adler, Jr -- Radiosurgical treatment of spinal chordomas / James P. Caruso, Mark H. Bilsky, Josh Yamada, and Ilya Laufer -- The role of radiosurgery in the treatment of primary malignant spine and spinal cord tumors / Moon-Jun Sohn, Dong-Joon Lee, and Hye-Ran Lee -- Radiosurgery for spinal cord arteriovenous malformations / Maziyar A. Kalani, Iris C. Gibbs, John R. Adler, Jr., and Steven D. Chang -- Multidisciplinary approach for the evaluation and treatment of metastatic spinal tumors / Ganesh M. Shankar, Kevin Oh, Kristina Shultz, and John H. Shin.
  • founding editors, Richard H. Rothman and Frederick A. Simeone.
    PrintStatus: Not Checked OutLane Catalog Record

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Derived from Current Medical Diagnosis & Treatment, AccessMedicine's Quick Medical Diagnosis & Treatment provides topic reviews with key diagnostic and treatment features for more than 500 diseases.

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed Plus is a clinical information resource used to answer questions quickly at the point-of-care. Easy-to-interpret Levels of Evidence help clinicians rapidly determine the quality of the available evidence.

Biomedical and pharmacological abstracting and indexing database of published literature, by Elsevier. Embase® contains over 32 million records from over 8,500 currently published journals (1947-present) and is noteworthy for its extensive coverage of the international pharmaceutical and alternative/complementary medicine literature.

Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialties.Provides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.

Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.

Stanford Medicine

Lane Medical Library