Books

all 826 "R" titles

R

  • 2007 Wiley
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    Michael J. Crawley.
    Preface -- 1. Getting started -- 2. Essentials of the R language -- 3. Data input -- 4. Dataframes -- 5. Graphics -- 6. Tables -- 7. Mathematics -- 8. Classical tests -- 9. Statistical modelling -- 10. Regression -- 11. Analysis of variance -- 12. Analysis of covariance -- 13. Generalized linear models -- 14. Count data -- 15. Count data in tables -- 16. Proportion data -- 17. Binary response variables -- 18. Generalized additive models -- 19. Mixed-effects models -- 20. Non-linear regression -- 21. Tree models -- 22. Time series analysis -- 23. Multivariate statistics -- 24. Spatial statistics -- 25. Survival analysis -- 26. Simulation models -- 27. Changing the look of graphics -- References and further reading -- Index.
  • 2012 CRCnetBASE
    Christopher Hay-Jahans.
    "Focusing on user-developed programming, An R Companion to Linear Statistical Models serves two audiences: Those who are familiar with the theory and applications of linear statistical models and wish to learn or enhance their skills in R; and those who are enrolled in an R-based course on regression and analysis of variance. For those who have never used R, the book begins with a self-contained introduction to R that lays the foundation for later chapters.This book includes extensive and carefully explained examples of how to write programs using the R programming language. These examples cover methods used for linear regression and designed experiments with up to two fixed-effects factors, including blocking variables and covariates. It also demonstrates applications of several pre-packaged functions for complex computational procedures"-- Provided by publisher.
  • 2011 ProQuest Safari
    Paul Teetor.
  • Robert A. Muenchen.
  • Click LINK above for Print location/circulation status.
    2006 CRCnetBASE
    Paul Murrell.
  • 2011 CRCnetBASE
    Paul Murrell.
    An introduction to R graphics -- Traditional graphics. Simple usage of traditional graphics -- Customizing traditional graphics -- Grid graphics. Trellis graphics : the lattice package -- The grammar of graphics : the ggplot2 package -- The grid graphics model -- The grid graphics object model -- Developing new graphics functions and objects -- The graphics engine. Graphics formats -- Graphical parameters -- Graphics packages. Graphics extensions -- Plot extensions -- Graphics for categorical data -- Maps -- Node-and-edge graphs -- 3D graphics -- Dynamic and interactive graphics -- Importing graphics -- Combining graphics systems.
  • 2011 ProQuest Safari
    Hrishi V. Mittal.
  • 2010 ProQuest Safari
    Joseph Adler.
  • 2012 CRCnetBASE
    Claus Thorn Ekstrøm.
  • 2009 CRCnetBASE
    Robert Gentleman.
    Also available: Print – 2009
  • 2010
    Ryan Michael Nottingham.
    Rab GTPases are master regulators of membrane trafficking in eukaryotic cells. With GTP bound, they regulate trafficking by recruiting effectors to specific membrane-bound compartments. GTPase-activating proteins (GAPs) stimulate a Rab's intrinsic rate of GTP hydrolysis, thus inactivating the Rab by converting bound GTP to GDP. Regulation of Rab proteins links the formation and breakdown of sequential, Rab-regulated membrane domains in the secretory and endocytic pathways. This thesis presents the characterization of a novel RabGAP, RUTBC1. RUTBC1 binds Rab9 in vitro and in cells through interactions with its N-terminus. Overexpression of RUTBC1 only slightly disrupts MPR trafficking and RUTBC1 does not function as a GAP for Rab9. In vitro biochemical screening of Rab proteins revealed that RUTBC1 has GAP activity toward Rab33b and Rab32. These data suggest that RUTBC1 might function to link inactivation of these Rabs in relation to a Rab9 microdomain, in support of the existence of a Rab cascade at the interface between the Golgi apparatus and endosomes. Depletion of RUTBC1 unexpectedly led to concomitant depletion of Atg16L1. Atg16L1 has an established and essential role in macroautophagy, a highly conserved cellular recycling process. Overexpression of Atg16L1 caused the formation of large puncta in the cytoplasm, which are also labeled by endogenous RUTBC1 and may represent autophagosomes. Atg16L1 is a known Rab33b effector, suggesting that Rab33b, RUTBC1 and Atg16L1 function together to regulate autophagosome formation. Finally, RUTBC2, which is highly related to RUTBC1, also binds specifically to Rab9. In vitro biochemical screening for RUTBC2's Rab substrates showed that RUTBC2 had highest GAP activity toward Rab34 and Rab36, two very similar Rabs thought to play a role in secretion. The difference in substrate specificity between RUTBC1 and RUTBC2 further exemplifies the highly complex integration of diverse membrane trafficking pathways in mammalian cells.
  • 2015 Springer Protocols
    edited by Guangpu Li.
    Rab family of GTPases / Guangpu Li and M. Caleb Marlin -- Bioinformatic approaches to identifying and classifying Rab proteins / Yoan Diekmann and José B. Pereira-Leal -- Rab-NANOPS : FRET biosensors for Rab membrane nanoclustering and prenylation detection in mammalian cells / Arafath Kaja Najumudeen ... [et al.] -- High-throughput assay for profiling the substrate specificity of Rab GTPase-activating proteins / Ashwini K. Mishraand David G. Lambright -- Measuring Rab GTPase-activating protein (GAP) activity in live cells and extracts / Ryan M. Nottingham and Suzanne R. Pfeffer -- Analysis of the interactions between Rab GTPases and class V myosins / Andrew J. Lindsay, Stéphanie Miserey-Lenkei, and Bruno Goud -- Assaying the interaction of the Rab guanine nucleotide exchange protein Sec2 with the upstream Rab, a downstream effector, and a phosphoinositide / Danièle Stalder and Peter J. Novick -- Kinetic activation of Rab8 guanine nucleotide exchange factor Rabin8 by Rab11 / Shanshan Feng ... [et al.] -- Ypt1 and TRAPP interactions : optimization of multicolor bimolecular fluorescence complementation in yeast / Zhanna Lipatova, Jane J. Kim, and Nava Segev -- Identifying a Rab effector on the macroautophagy pathway / Juan Wang ... [et al.] -- Functional analysis of Rab27A and its effector Slp2-a in renal epithelial cells / Takao Yasuda, Paulina S. Mrozowska, and Mitsunori Fukuda -- Small GTPases in acrosomal exocytosis / Matias A. Bustos ... [et al.] -- Rab antibody characterization : comparison of Rab14 antibodies / Andrew J. Lindsay and Mary W. McCaffrey -- Selective visualization of GLUT4 storage vesicles and associated Rab proteins using IRAP-pHluorin / Yu Chen and Jennifer Lippincott-Schwartz -- 3D time-lapse analysis of Rab11/FIP5 complex : spatiotemporal dynamics during apical lumen formation / Anthony Mangan and Rytis Prekeris -- In vitro and in vivo characterization of the Rab11-GAP activity of drosophila Evi5 / Carl Laflamme and Gregory Emery -- Characterization of the role Rab25 in energy metabolism and cancer using extracellular flux analysis and material balance / Shreya Mitra ... [et al.] -- Measurement of Rab35 activity with the GTP-Rab35 trapper RBD35 / Hotaka Kobayashi ... [et al.] -- Analysis of connecdenn 1-3 (DENN1A-C) GEF activity for Rab35 / Patrick D. Allaire, Peter S. McPherson, and Brigitte Ritter -- Assay of Rab17 and its guanine nucleotide exchange factor Rabex-5 in the dendrites of hippocampal neurons / Yasunori Mori and Mitsunori Fukuda -- Methods for analysis of AP-3/Rabin4' in regulation of lysosome distribution / Viorica Ivan and Peter van der Sluijs -- Determination of Rab5 activity in the cell by effector pull-down assay / Yaoyao Qi ... [et al.] -- Identification of the Rab5 binding site in p110[beta] : assays for PI3K[beta] binding to Rab5 / Rachel S. Salamon ... [et al.] -- Role of the Rab5 guanine nucleotide exchange factor, Rme-6, in the regulation of clathrin-coated vesicle uncoating / Elizabeth Smythe -- Differential effects of overexpression of Rab5 and Rab22 on autophagy in PC12 cells with or without NGF / M. Caleb Marlin and Guangpu Li -- Determining the role of Rab7 in constitutive and ligand- mediated epidermal growth factor receptor endocytic trafficking using single cell assays / Brian P. Ceresa -- Visualizing directional Rab7 and TrkA cotrafficking in axons by pTIRF microscopy / Kai Zhang, Praveen D. Chowdary, and Bianxiao Cui -- Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein / Jacob O. Agola ... [et al.].
  • 2007
    [prepared by D. Warrell and J-M Gutierrez].
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Sudhi Ranjan Garg.
    Rabies is the deadliest zoonotic disease that threatens humans and animals on all continents except Antarctica. Asia and Africa are worst affected as more than 95 per cent of rabies associated human deaths occur in these regions. India alone bears about 36 per cent of the global human rabies burden. Dogs are the main transmitters of rabies that potentially threaten over 3 billion people in Asia and Africa. Many developed nations have been able to successfully control dog rabies but continue to face the risk from wildlife including bats.
  • 2013 ScienceDirect
    edited by Alan C. Jackson, University of Manitoba, Winnipeg, MB, Canada.
    History of rabies research -- Rabies virus -- Epidemiology -- Molecular epidemiology -- Rabies in terrestrial animals -- Bat rabies -- Human disease -- Pathogenesis -- Pathology -- Immunology -- Laboratory diagnosis of rabies -- Measures of rabies immunity -- Rabies vaccines -- Next generation of rabies vaccines -- Public health management of humans at risk -- Therapy of human rabies -- Dog rabies and its control -- Rabies control in wild carnivores -- Blueprint for rabies prevention and control -- Future developments and challenges.
  • 2007
    Todd L. Savitt.
    "In Race and Medicine historian Todd Savitt presents revised and updated versions of his seminal essays on the medical history of African Americans in the late nineteenth and early twentieth centuries, especially in the South. This collection examines a variety of aspects of African American medical history, including health and illnesses, medical experimentation, early medical schools and medical professionals, and slave life insurance."--Jacket.
  • 2009 Springer
    [edited by] Samy Bendaya, Jean-Claude Goussard.
  • 2012 Karger
    editor, Diana T. Slaughter-Defoe.
    Introduction / Slaughter-Defoe, D.T -- Through the eyes of a child : the development and consequences of racial stereotypes in black and white children / Bogan, E.D., Slaughter-Defoe, D.T. -- Should stereotype consciousness be taught to children? A discussion informed by Bogan and Slaughter-Defoe's through the eyes of a child. Commentary on Bogan and Slaughter-Defoe / Bigler, R.S., Wright, Y. -- What's not in the box? Historical and population change as contextual features in the study of race-based development of children. Commentary on Bogan and Slaughter-Defoe / Johnson, D.J. -- Media socialization, black media images and black adolescent identity / Adams, V.N., Stevenson, H.C. -- Adolescents, race, and media. Commentary on Adams and Stevenson / Taylor Piotrowski -- Damned if you do and damned if you don't! What are the correct media images for black people in the media and how can we know? Commentary on Adams and Stevenson / Jones, J.M. -- Social media, privacy and identity. Commentary on Adams and Stevenson / Matwyshyn, A.M -- "What does race have to do with math?" Relationships between racial-mathematical socialization, mathematical identity, and racial identity / English-Clarke, T.L., Slaughter-Defoe, D.T., Martin, D.B. -- "What do race and math have to do with each other?" Relationships between racial-mathematical socialization, mathematical identity, and racial identity. Commentary on English-Clarke, Slaughter-Defoe, and Martin / McGee, E. -- The need to incorporate observations of implicit socialization in the contexts of everyday life. Commentary on English-Clarke, Slaughter-Defoe, and Martin / Miller, P.J., Bracey, J.R. -- "What does race have to do with math?" Relationships between racial-mathematical socialization, mathematical identity, and racial identity. Commentary on English-Clarke, Slaughter-Defoe, and Martin / Beale Spencer, M. -- On researching the agency of Africa's young citizens : issues, challenges and prospects for identity development / Nsamenang, A.B. -- On researching the agency of youth : moving beyond traditional theorizing. Commentary on Nsamenang / Thompson, C.I. -- Advancing an African research agenda for child development. Commentary on Nsamenang / Murphy, K.M. -- Epilogue / Slaughter-Defoe, D.T.
  • 2008 Springer
    edited by Ronald Hall.
  • 2012 Thieme Book
    edited by Shailendra Chopra ; series editors, Jonathan Lorenz, Hector Ferral.
  • 2014 Springer
    edited by Koichi Tanigawa, Rethy Kieth Chhem.
    The role of disaster medicine is becoming more important as the frequency and severity of natural and technological disasters increase. The triple disaster that occurred in Fukushima on March 11, 2011 calls for innovation in the training of health care professionals, pre-hospital emergency care providers, and emergency personnel in the management of the medical consequences of radiation disasters. While many books are available on disaster medicine, none is specifically devoted to the role of physicians in the management of patients exposed to radiation leakage from a damaged nuclear power plant. Radiation Disaster Medicine aims to fill this void based on the response to the Fukushima nuclear accident. Each chapter addresses principles and practices of radiation medicine within the specific context of that accident. Topics covered include the role of physicians in radiation disasters, the concepts of external and internal exposure, prehospital and hospital response, disaster behavioral health, and radiation emergency response from the perspective of national and international institutions. Most of the contributors are active educators and researchers in radiation medicine with first-hand experience in dealing with prehospital triage and management of patients within secondary and tertiary care hospitals in Japan. It is hoped that this book will assist in attaining the ultimate goal of radiation disaster medicine: to help the patients.
  • 2007 Springer
    D. Tack, P.A. Gevenois (eds.) ; with contributions by H.T. Abada ... [et al.] ; foreword by A.L. Baert.
  • 2012 Springer
    Denis Tack, Mannudeep K. Kalra, Pierre Alain Gevenois, editors ; foreword by Maximilian F. Reiser.
    Multi-Detector Row CT-Recent Developments, Radiation Dose and Dose Reduction Technologies / Thomas Flohr -- Clinical Expansion of CT and Radiation Dose / Stuart Meeson, Rajesh Patel and Stephen Golding -- Risks from Ionising Radiation / Kenneth H. Chadwick and Hendrik P. Leenhouts -- The Cancer Risk from Low Level Radiation / Bernard L. Cohen -- Image Quality in CT: Challenges and Perspectives / Thomas L Toth -- Radiation Dose Metrics and the Effect of CT Scan Protocol Parameters / Sue Edyvean, Maria Lewis and Alan Britten -- Scan Parameters and CT Radiation Dose / Sarabjeet Singh and Mannudeep K. Kalra -- Optimization of Tube Potential for Radiation Dose Reduction in CT / Lifeng Yu, Joel G. Fletcher and Cynthia H. McCollough -- Conventional and Newer Reconstruction Techniques in CT / Homer Pien, Synho Do, Sarabjeet Singh and Mannudeep K. Kalra -- Image Noise Reduction Filters / Sarabjeet Singh and Mannudeep K. Kalra -- Hardware Developments for Radiation Dose Reduction / Rich Mather -- Application of Shielding in CT Radiation Dose Reduction / Shima Aran, Sarabjeet Singh and Mannudeep K. Kalra -- Radiation Dose: Records and Audits / Tessa S. Cook, William W. Boonn and Woojin Kim -- Collective Radiation Dose from MDCT: Critical Review of Surveys Studies / Georg Stamm. ALARA Concept for MDCT Optimization: What is Reasonable, What is Achievable? / Denis Tack -- Automatic Exposure Control in Multidetector-row CT / Mannudeep K. Kalra -- Patient Centering in MDCT: Dose Effects / Mannudeep K. Kalra and Thomas L. Toth -- Dose Optimization and Reduction in CT of the Brain and Head and Neck Region / Tom Mulkens, Rodrigo Salgado and Patrick Bellinck -- Dose Reduction and Optimization in Computed Tomography of the Chest / Pierre Alain Gevenois and Denis Tack -- Dose Optimization and Reduction in MDCT of the Abdomen / Caroline Keyzer and Denis Tack -- Radiation Dose Optimisation of Cardiac and Vascular MDCT in Adults and Paediatric Patients / Jean François Paul, Caroline Keyzer, Michelle Williams and Denis Tack -- Dose Optimization and Reduction in Musculoskeletal CT Including the Spine / A. Gervaise, P. Teixeira, N. Villani, S. Lecocq and M. Louis, et al. -- Dose Reduction in CT Fluoroscopy / N. Buls, F. Vandenbroucke and J. de Mey -- Dose Optimization and Reduction in CT of Children / Peter Vock, Enno Stranzinger and Rainer Wolf -- CT Scanning in Pregnancy / D. E. Litmanovich and A. A. Bankier -- Radiation Risk Associated with Lung Cancer Screening / Cornelia Schaefer-Prokop, Krijn van Muiswinkel and Mathias Prokop. Dose Reduction in Screening Programs: Colon Cancer Screening / Thierry N. Boellaard, Henk W. Venema and Jaap Stoker -- CT Dose Perspectives and Initiatives of the IAEA / Madan M. Rehani and Olivera Ciraj-Bjelac -- The Image Gently Campaign: Championing Radiation Protection for Children Through Awareness, Educational Resources and Advocacy / Marilyn J. Goske, Michael J. Callahan, Donald P. Frush, Sue C. Kaste and Gregory Morrison, et al. -- CT Radiation Dose and Safety: Perspectives at the U.S. Food and Drug Administration / Stanley H. Stern, Sean Boyd, Kish Chakrabarti, Iacovos S. Kyprianou and Thalia T. Mills, et al. -- ICRP's Role in Patient Dose Management in CT / Madan M. Rehani -- Software for Calculating Dose and Risk / Georg Stamm -- Image Wisely / James A. Brink and E. Stephen Amis -- Guidelines for Appropriate CT Imaging / Kristie M. Guite, J. Louis Hinshaw, Frank N. Ranallo and Fred T. Lee -- Practical Approaches to Dose Reduction: GE Perspective / Roy A. Nilsen -- Dose Reduction in Computed Tomography Siemens Perspective / Christianne Leidecker and Bernhard Schmidt -- CT Radiation Dose: Philips Perspective / Alain Vlassenbroek, Dhruv Mehta and Jeffrey Yanof -- Practical Approaches to Dose Reduction: Toshiba Perspective / Jacob Geleijns and R Irwan.
  • 2012 Springer
    by Horst Aichinger ... [et al.].
  • 2009 Springer
    M. Nakashima ... [et al.], (eds.).
  • 2010 Springer
    Charles L. Sanders.
  • 2012 CRCnetBASE
    Kedar N. Prasad.
    Ch. 1. Growing health concerns with respect to low doses of ionizing radiation : can we prevent and/or mitigate them? -- ch. 2. Physics of radiological weapons and nuclear reactors -- ch. 3. Acute radiation damage by high doses of ionizing radiation in humans -- ch. 4. Long-term damages among survivors of high doses of ionizing radiation -- ch. 5. Prevention and mitigation of acute radiation sickness (ARS) -- ch. 6. Prevention and mitigation of late adverse effects of high radiation doses -- ch. 7. Health risks of low doses of ionizing radiation -- ch. 8. Prevention and mitigation against radiological weapons and nuclear plant accidents -- ch. 9. Prevention and mitigation of damage after low radiation doses -- ch. 10. Implementation plans for prevention and mitigation of radiation injury -- ch. 11. Health risks of nonionizing radiation and their prevention and mitigation.
  • 2013 Springer
    Tapan K. Gupta.
    Nuclear Radiation, Ionization, and Radioactivity -- Radiation Exposure: Consequences, Detection, and Measurements -- Mathematical Modeling of Radiation -- Medical Imaging -- Basic Principles of Radiation Detectors -- Theoretical Approach of Crystal and Film Growths of Materials Used in Medical Imaging System -- Device Fabrication (Scintillators/Radiation Detectors) -- Characterization of Radiation Detectors (Scintillators) Used in Nuclear Medicine -- Instrumentation and Its Applications in Nuclear Medicine.
  • 2008 Springer
    J.J. Lu, L.W. Brady (eds.).
  • 2002 Ovid
    K.S. Clifford Chao, Carlos A. Perez, Luther W. Brady.
    Also available: Print – 2002
  • 2012 Springer
    Murat Beyzadeoglu, Gokhan Ozyigit, Ugur Selek.
    Radiation Physics -- Radiobiology -- Clinical Radiation Oncology -- Central Nervous System Tumors -- Head and Neck Cancers -- Lung Cancer -- Breast Cancer -- Genitourinary System Cancers -- Gynecological Cancers -- Gastrointestinal System Cancers -- Soft Tissue Sarcoma -- Skin Cancer -- Lymphomas and Total Body Irradiation -- Pediatric Tumors -- Rare Tumors and Benign Diseases.
  • 2015 Ovid
    editors Boris Hristov, Steven H. Lin, John P. Christodouleas.
    Pediatrics -- Central nervous system -- Eye -- Head and neck -- Thorax -- Breast -- Gastrointestinal -- Genitourinary -- Gynecology -- Hematology -- Bone -- Soft tissue sarcoma -- Skin -- Palliative -- Benign disease
  • 2008. Springer
    edited by Søren M. Bentzen ... [et al.].
    Also available: Print – 2008
  • 2011 Ovid
    [edited by] K.S. Clifford Chao, Carlos A. Perez, Luther W. Brady, [assistant editor], Tim Marinetti.
    Ideal for on-the-spot consultation, this pocket manual, Radiation Oncology: Management Decisions, provides easily accessible information for residents and practitioners in radiation oncology. It presents the most essential information that is immediately required in the clinical setting. The first eight chapters of the book focus on key basic concepts; the remaining 46 chapters describe treatment regimens for all cancer sites and tumor types. Includes coverage of pain and palliation, and covers all latest therapeutic techniques. This edition includes expanded information on image-guided therapy, 3D techniques, and 4D protocols. The updated cancer staging guidelines have been used throughout the manual. In addition, there is a brand-new chapter devoted to QUANTEC dosage recommendations.
  • 2010 ClinicalKey
    [edited by] James D. Cox, K. Kian Ang.
    Radiation Oncology: Rationale, Technique, Results, by James D. Cox, MD and K. Kian Ang, MD, PhD, provides you with authoritative guidance on the latest methods for using radiotherapy to treat patients with cancer. Progressing from fundamental principles through specific treatment strategies for the cancers of each organ system, it also addresses the effects of radiation on normal structures and the avoidance of complications. This 9th edition covers the most recent indications and techniques in the field, including new developments in proton therapy and intensity-modulated radiotherapy (IMRT). It also features, for the first time, full-color images throughout the text to match those that you see in practice, and uses new color-coded treatment plans to make targets, structures, and doses easier to read at a glance. Evidence from randomized clinical trials is included whenever possible to validate clinical recommendations. The state-of-the-art coverage inside this trusted resource equips you to target cancer as effectively as possible while minimizing harm to healthy tissue. Stands apart as the only book in the field to cover the conceptual framework for the use of radiotherapy by describing the most effective techniques for treatment planning and delivery and presenting the results of each type of therapy. Emphasizes clinical uses of radiation therapy, providing pertinent, easy-to-understand information on state-of-the-art treatments. Includes information useful for non-radiotherapists, making it "recommended reading" for other oncology specialists. Offers a practical, uniform chapter structure to expedite reference.
  • 2013 Springer
    Celine Bicquart Ord, Eric K. Hansen, Charles R. Thomas, Jr, editors.
    Central Nervous System Tumors: Adult and Pediatric -- Skin Cancer -- Head and Neck Cancer -- Lung Cancer -- Tumors of the Mediastinum -- Breast Cancer -- Upper Gastrointestinal Cancers -- Lower Gastrointestinal Cancers -- Urinary System Cancers -- Male Genitourinary Cancer -- Gynecologic Malignancies -- Hematologic Malignancies -- Sarcoma -- Pediatric Non-central Nervous System Cancers -- Benign and Metastatic Disease.
  • 2006 Springer
    E.B. Podgoršak.
  • 2011 Springer
    Marie Claire Cantone, Christoph Hoeschen, editors.
    The role of radiation physics in nuclear medicine -- The molecular imaging pathway to biomedical physics -- Mechanisms of the interactions between radiation and matter -- Principles of monte carlo calculations and codes -- Sealed radionuclide and X-Ray sources in nuclear medicine -- Radiopharmaceutical production -- Research and development of new radiopharmaceuticals -- Basic principles of detection of ionizing radiation used in medical imaging -- Scintillators and semiconductor detectors -- New trends in detectors for medical imaging -- The PET magnifier probe -- Algorithms for image reconstruction -- Biokinetic models for radiopharmaceuticals -- Voxel phantoms for internal dosimetry.
  • 2013 Springer
    Sören Mattsson, Christoph Hoeschen, editors.
    This book explains clearly and in detail all aspects of radiation protection in nuclear medicine. After an introductory chapter on the general role of radiation protection, measurement quantities and units are discussed, and detectors and dosimeters, described. Radiation biology and radiation dosimetry are then addressed, with the inclusion of a chapter specifically devoted to biology and dosimetry for the lens of the eye. Discussion of radiation doses to patients and to embryos, fetuses, and children forms a central part of the book. Phantom models, biokinetic models, calculations, and software solutions are all considered, and a further chapter focuses on quality assurance and reference levels. Occupational exposure also receives detailed attention. Exposure resulting from the production, labeling, and injection of radiopharmaceuticals and from contact with patients is discussed and shielding calculations are explained. The book closes by considering exposure of the public and summarizing the "rules of thumb" for radiation protection in nuclear medicine. This is an ideal textbook for students and a ready source of useful information for nuclear medicine specialists and medical physics experts.
  • 2013 Springer
    Dariusz Leszczynski, editor.
    Methods of proteomics have been shown to be powerful tools in search of target proteins - proteins that respond in cells to an internal or an external stimulus. Proteomics is widely used in biomedical research. However, in radiation biology research, following exposures of living matter to low doses of either ionizing or non-ionizing radiation, proteomics approach is only very slowly gaining support. This book, by presenting the current status of the use of proteomics in radiation biology, will help to attract attention to the field of radiation proteomics.
    Also available: Print – 2013
    Also available: Print – 2013
  • 2007 CRCnetBASE
    Kenneth L. Mossman.
  • 2007 CRCnetBASE
    Max H. Lombardi.
    Also available: Print – 2007
  • 2015 Springer
    Murat Beyzadeoglu, Gokhan Ozyigit, Ugur Selek, editors.
  • 2015 Springer
    Eli D. Ehrenpreis, R. de W. Marsh, William Small, Jr., editors.
    This book provides a state-of-the-art review of the role of radiation therapy in various pelvic malignancies as well as the consequences of the radiation in the pelvic tissues. With sections covering the role of radiation therapy in the various pelvic malignancies, the pathophysiology of radiation related injury and the risk factors that increase the possibility of such an injury, and the latest in medical, endoscopic and surgical therapies for these radiation related complications the text offers a concise yet comprehensive overview of radiation therapy in the human pelvis, its role and the adverse effects on the pelvic organs. Written by experts in the field with readers in mind, Radiation Therapy for Pelvic Malignancy and its Consequences is the first of its kind standalone reference on the subject. ℗ℓ Radiation Therapy for Pelvic Malignancy and its Consequences is of great value to urologists, medical radiation and gynecological oncologists, and gastroenterologists.
  • 2013 Springer
    Armand B. Cognetta Jr., William M. Mendenhall, editors.
    History of radiation therapy in dermatology -- Radiobiology -- Physical aspects of dermatological radiotherapy -- Radiation protection -- Staging of squamous cell carcinoma and basal cell carcinoma -- Acute and chronic cutaneous reactions to radiotherapy -- Efficacy of superficial radiotherapy -- Treatment selection for superficial radiotherapy -- Superficial radiation therapy treatment planning -- Current use of dermatologic radiotherapy in the United States -- Grenz ray therapy -- Radiotherapy for cutaneous squamous and basal cell carcinomas -- Brachytherapy -- Cutaneous merkel cell carcinoma -- Radiotherapy for cutaneous angiosarcoma -- Radiotherapy for dermatofibrosarcoma protuberans -- Squamous and basal cell carcinomas with perineural invasion -- Getting started in superficial radiation for the dermatology practice.
  • 2001 Karger
    volume editor, J.L. Meyer.
    Also available: Print – 2001
  • 2016 Springer
    Amy Heath.
    This book is a comprehensive review and study aid for radiation therapists. Organized in a question-and-answer format, it present clinical features and principles of treatment. Topics include radiation therapy physics, radiobiology, treatment and simulation equipment, principles of patient care, clinical components of cancer care, and cancers of the brain, head and neck region, and respiratory, digestive, urinary, and male and female reproductive systems. It offers over 500 multiple-choice questions with detailed answers and rationales. Radiation Therapy Study Guide is a valuable resource for radiation therapists preparing for certification examinations as well as for practicing therapists in need of a review.
  • 2006 Springer
    edited by William Small, Jr., Gayle E. Woloschak.
    Also available: Print – 2006
  • 2015 Springer
    Renato G. Panizzon, M. Heinrich Seegenschmiedt, editors.
    In this book, leading experts in the dermatological and oncological field describe the use of radiation therapy for the treatment of the full range of dermatological malignancies ? including basal cell carcinoma, squamous cell carcinoma, cutaneous lymphomas, Kaposi's sarcoma, melanoma, and Merkel cell tumor ? as well as those precancerous lesions and non-malignant dermatological disorders which are amenable to radiation therapy. In each case the specific indications for the use of radiotherapy and its application are clearly explained with the aid of numerous high-quality illustrations. In addition, the book provides a concise introduction to physical and radiobiological principles, selection of radiation factors, dose definitions, radiation reactions, and risk assessments. The new edition has been thoroughly revised and updated to reflect advances in practical knowledge and clinical practice. It will be an invaluable source of information on the management of skin tumors and related non-malignant disorders for both dermatologists, oncologists and radiation oncologists.
  • 2014 Springer
    James A. Eastham, Edward M. Schaeffer, editors.
    Radical Prostatectomy: Surgical Perspectives provides surgeons with a comprehensive overview of the anatomical approach to radical prostatectomy, whether done through an open (retropubic) or robotic-assisted laparoscopic approach. All chapters are structured to provide a step-by-step approach to the most technically demanding and most common oncologic procedure in urology surgery. The book includes highly practical presentations of typical surgical patients seen in the clinical practice of urology and relies heavily on illustrations and intraoperative photographs to clearly complement the text. In addition, the book ?includes a detailed description of the management of uncommon but potentially serious intraoperative complications, including major vascular injury, ureteral transaction, and rectotomy. Written by authors from a variety of integrated disciplines, including anesthesia, cardiology, and nursing Radical Prostatectomy: Surgical Perspectives is a unique and valuable resource in the field of urology both for those currently in training and for those already in surgical practices.
  • v. 1-2, 1968-1970.
    Quimby, Edith Hinkley; Silver, Solomon.
    Status: Not Checked OutLane Catalog Record
    [1] Basic physics and instrumentation by E. H. Quimby [and others]--[2] Medicine, by S. S. Silver.
  • 2006
    Eric J. Hall, Amato J. Giaccia.
    Status: Not Checked OutLane Catalog Record
    Physics and chemistry of radiation absorption -- DNA strand breaks and chromosomal aberrations -- Cell survival curves -- Radiosensitivity and cell age in the mitotic cycle -- Repair of radiation damage and the dose-rate effect -- Oxygen effect and reoxygenation -- Linear energy transfer and relative biologic effectiveness -- Acute effects of total-body irradiation -- Radioprotectors -- Radiation carcinogenesis -- Hereditary effects of radiation -- Effects of radiation on the embryo and fetus -- Radiation cataractogenesis -- Doses and risks in diagnostic radiology, interventional radiology and cardiology, and nuclear medicine -- Radiation protection -- Molecular techniques in radiobiology -- Cancer biology -- Dose-response relationships for model normal tissues -- Clinical response of normal tissues -- Model tumor systems -- Cell, tissue, and tumor kinetics -- Time, dose, and fractionation in radiotherapy -- Predictive assays -- Alternative radiation modalities -- Radiosensitizers and bioreductive drugs -- Gene therapy -- Chemotherapeutic agents from the perspective of the radiation biologist -- Hyperthermia.
  • 2012
    Eric J. Hall, Amato J. Giaccia.
    Physics and Chemistry of Radiation Absorption -- Molecular Mechanisms of DNA and Chromosome Damage and Repair -- Cell Survival Curves -- Radiosensitivity and Cell Age in the Mitotic Cycle -- Fractionated Radiation and the Dose-Rate Effect -- Oxygen Effect and Reoxygenation -- Linear Energy Transfer and Relative Biologic Effectiveness -- Acute Radiation Syndrome -- Radioprotectors -- Radiation Carcinogenesis -- Heritable Effects of Radiation -- Effects of Radiation on the Embryo and Fetus -- Radiation Cataractogenesis -- Radiologic Terrorism -- Molecular Imaging -- Doses and Risks in Diagnostic Radiology, Interventional Radiology and Cardiology, and Nuclear Medicine -- Radiation Protection -- Cancer Biology -- Dose-Response Relationships for Model Normal Tissues -- Clinical Response of Normal Tissues -- Model Tumor Systems -- Cell, Tissue, and Tumor Kinetics -- Time, Dose, and Fractionation in Radiotherapy -- Retreatment after Radiotherapy: The Possibilities and the Perils -- Alternative Radiation Modalities -- The Biology and Exploitation of Tumor Hypoxia -- Chemotherapeutic Agents from the Perspective of the Radiation Biologist -- Hyperthermia.
  • 2016 Springer
    Luigi Pirtoli, Giovanni Luca Gravina and Antonio Giordano, editors.
    Introduction and Background -- The "Radio-resistance" of Glioblastoma in the Clinical Setting, and the Present Therapeutic Options -- Radiobiological Hints from Clinical Studies -- Chemo-radiotherapy: Radiation Total Dose and Fractionation -- Clinical Evidence and Radiobiological Background of Particle Radiation Therapy -- Mathematical Modeling of Radiobiological Parameters from Clinical Studies -- Clinical, Pathology and Molecular Prognostic Parameters of Response to Chemo- and Radiotherapy from Clinical Series -- Radiation Tolerance of Normal Brain: QUANTEC 2010 and Beyond -- Basic Knowledge of Glioblastoma Radiobiology -- Molecular Radiobiology and Mathematical Modeling -- Genetic and Epigenetic Determinants in Tumor Initiation and Progression -- Tumor Microenvironment -- Cell Death Pathways, with Special Regard to Ionizing Radiation and Temozolomide Therapy -- mi-RNA Manipulation in Modifying Radiation Sensitivity in Glioblastoma Models -- Glioma Stem-like Cells and Radiation Resistance -- Hypoxia and Radiation Resistance -- Invasiveness and Radiation Failures -- Nanoparticle Technology for Research Radiobiology -- The Molecular Classification of Glioblastoma as a Translational Instrument -- Translational Perspectives for Gene Therapy -- Pre-Clinical Models of Glioblastoma in Radiobiology: Evolving Protocols and Research Methods -- From Molecular to Clinical Radiation Biology -- Perspectives of the Large Data-Bases and Ontologic Models of Correlation of Pre-clinical and Clinical Results -- Conclusive Remarks and Perspectives for Future Research.
  • 2016 Springer
    Minshan Chen, Yaojun Zhang, Wan Y. Lau, editors.
    Diagnosis of small Hepatocellular carcinoma -- Pathobiologic characteristics of small hepatocellular carcinoma -- Radiofrequency ablation systems and operating mechanisms -- Initial Clinical Assessment and Patient Selection -- Percutaneous Radiofrequency Thermal Ablation -- Laparoscopic and Open RFA -- Peri-RFA care and management of complications -- Combined therapies of RFA -- Radiological assessment and follow-up after radiofrequency -- Adjuvant therapy after Radiofrequency Ablation -- Surgery vs Radiofrequecy Ablation for Small Hepatocellular Carcinoma.
  • 2012 Thieme Book
    S. Lowell Kahn [and others].
    "Despite the advent of modern cross-sectional imaging, skeletal radiographs remain at the crux of the initial diagnosis, particularly in the emergency and outpatient settings. The images contained herein represent composite individuals obtained at three-month intervals for the first two years of life and at yearly intervals thereafter. The authors provide a comprehensive set of reference images that document the progressive skeletal development, demonstrating the configuration, density, and relative size of the various body parts for males and females. Given the broad application of radiographs in the clinical setting, this atlas is not only intended for practicing and training radiologists, but for all of those who employ radiographs as part of their practice"--Provided by publisher.
  • 2007 Springer
    Massimo Gallucci, Silvia Capoccia, Alessia Catalucci.
  • v. 1-2, 1919. Google Books
    Fulltext (v.2 1919) Google Books
    by Robert Knox.
    Also available: Print – v. 1-2, 1919.
  • Google Books
    by Walker Overend.
    I. Pulmonary tuberculosis -- II. Non-tuberculous affections.
  • 2016 Springer
    Ken Herrmann, Omgo E. Nieweg, Stephen P. Povoski, editors.
    Part 1 Introduction -- The History of Radioguided Surgery: Early Historical Milestones and the Development of Later Innovative Clinical Applications -- Part 2 Detailed Methodology Part -- Physics of Radioguided Surgery -- The use of intraoperative small and large field of view gamma cameras for radioguided surgery -- Surgical Navigation -- Tracers applied in radioguided surgery -- Radiation Safety and Dosimetry -- Part 3 Clinical Application: Breast -- Radioguided sentinel lymph node mapping and biopsy in breast cancer -- Radioguided Surgery for Non-Palpable Breast Lesions: I-125 Radioactive Seed Localization.- Radioguided Surgery for Non-Palpable Breast Lesions: Technetium-99m Radioguided Occult Lesion Localization (ROLL) -- Part 4 Clinical Application: Skin -- Radioguided sentinel lymph node mapping and biopsy in cutaneous melanoma -- Part 5 Clinical Application: Head and Neck -- Sentinel lymph node mapping and biopsy in oral cancer -- Part 6 Clinical Application: Thyroid and Parathyroid -- Radioguided sentinel lymph node mapping and biopsy in thyroid cancer -- Radioguided Parathyroid Surgery -- Radioguided surgery of thyroid carcinoma recurrences -- Part 7 Clinical Application: Urogenital Tract -- Radioguided sentinel lymph node biopsy and lymphatic mapping in urogenital malignancies -- Radioguided sentinel lymph node mapping and biopsy in Gynaecological malignancies -- Part 8 Clinical Application: Gastrointestinal Tract -- Radioguided sentinel lymph node mapping and biopsy in oesophago-gastric -- Radioguided sentinel lymph node mapping and biopsy in colorectal cancer -- Radioguided surgery in gastro-entero-pancreatic neuroendocrine tumors -- Part 9 Clinical Application: Thoracic -- Radioguided sentinel lymph node mapping and biopsy in non-small-cell lung cancer (NSCLC) -- Radioguided surgery of small pulmonary nodules -- Part 10 Miscellaneous -- Radioguided localization of bone lesions -- Radioguided monitoring of systemic leakage during isolated limb perfusion -- Radioimmunoguided Surgery: Intraoperative radioimmunodetection for the radioguided localization and resection of tumors -- 18F-FDG-Directed Surgery and 18F-FDG-Directed Interventional Procedures -- Part 11 Outlook: New techniques, image fusion, optical imaging -- Fluorescent tracers, hybrid tracers -- Magnetic Advances in Cancer Surgery -- Ultrasound fusion -- Part 12 Examples (conventional techniques and innovations). .
  • 2008 Springer
    edited by Giuliano Mariani, Armando E. Giuliano, H. William Strauss.
    Part I. Chemistry and Physics -- Radiopharmaceuticals for Radioguided Surgery / Esteban Obenaus, Paola A. Erba, Marco Chinol, Christophe Van de Wiele and Gyozo A. Janoki, et al. -- Physical Performance Parameters of Intraoperative Probes / Carlo Chiesa, Francesca Toscano, Mario Mariani and Emilio Bombardieri -- Positron-Sensitive Probes / Schlomo Schneebaum, Richard Essner and Einat Even-Sapir -- Gamma Ray Imaging Probes for Radioguided Surgery and Site-Directed Biopsy / Francesco Scopinaro and Alessandro Soluri -- Radiation Protection in Radioguided Surgery / Edwin C. Glass and Wendy A. Waddington -- Training and Credentialing for Radioguided Surgery / Eric D. Whitman -- Part II. Sentinel Lymph Nodes -- The Anatomy and Physiology of Lymphatic Circulation / Preya Ananthakrishnan, Giuliano Mariani, Luciano Moresco and Armando E. Giuliano -- The Role of Lymph Node Staging for Clinical Decision Making in Patients with Solid Cancers / Fausto Badellino, Ilaria Pastina, Elisa Borsò, Sergio Ricci and H. William Strauss, et al. -- Sentinel Lymph Node Biopsy in Patients with Breast Cancer / Charles E. Cox, John M. Cox, Giuliano Mariani, Caren E.G. Wilkie and Laura B. White, et al. -- Sentinel Lymph Node Biopsy in Cutaneous Melanoma / Jeffrey E. Gershenwald, Roger F. Uren, Giuliano Mariani and John F. Thompson -- Dynamic Sentinel Lymph Node Biopsy in Penile Carcinoma / Simon Horenblas, Bin K. Kroon, Renato A. Valdés Olmos and Omgo E. Nieweg -- Sentinel Lymph Node Biopsy in Cancer of the Head and Neck / Luca Calabrese, David Soutar, Jochen Werner, Roberto Bruschini and Concetta De Cicco, et al. -- Sentinel Lymph Node Biopsy in Gynecologic Malignancies / Emilio Bombardieri, Marco Maccauro, Rosanna Fontanelli, Francesco Raspagliesi and Giovanni Paganelli -- Sentinel Lymph Node Biopsy in Cancers of the Gastrointestinal Tract / Yuko Kitagawa, Sukamal Saha and Masaki Kitajima -- Sentinel Lymph Node Biopsy in Prostatic Cancer / Alexander Winter, Harry Vogt, Dorothea Weckermann, Rolf Harzmann and Friedhelm Wawroschek -- Radioguided Biopsy of the Sentinel Lymph Node in Patients with Non-Small Cell Lung Cancer / Giuseppe Boni, Gianpiero Manca, Franca M. A. Melfi, Marco Lucchi and Alfredo Mussi, et al. -- Sentinel Lymph Node Biopsy in Thyroid Cancer / Massimo Salvatori, Domenico Rubello, Michael J. O'Doherty, Maria Rosa Pelizzo and Giuliano Mariani -- Histopathology of Sentinel Lymph Nodes / Giuseppe Viale, Giovanni Mazzarol and Eugenio Maiorano -- Frozen Section and Imprint Cytology in Sentinel Lymph Node Biopsy for Breast Cancer / Santo V. Nicosia and Charles E. Cox -- Molecular Assessment of Sentinel Lymph Nodes / Farin Amersi, Armando E. Giuliano and Dave S.B. Hoon -- Part III. Occult Lesion Localization -- Where It All Began: The Heritage of Radioimmunoguided Surgery / Fausto Badellino, Mario Roselli, Marzio Perri, Fiorella Guadagni and Giuliano Mariani -- Radioguided Occult Lesion Localization in the Breast / Giovanni Paganelli, Concetta De Cicco, Giovanna Gatti and Alberto Luini -- Minimally Invasive Radioguided Parathyroidectomy in Primary Hyperparathyroidism / James Norman, Domenico Rubello, Armando E. Giuliano and Giuliano Mariani -- Radioguided Surgery of Neuroendocrine Tumors / Richard P. Baum, Sergio Sandrucci and Stefan Adams -- Radioguided Surgery of Solitary Pulmonary Nodules / Giuseppe Boni, Franca M. A. Melfi, Gianpiero Manca, Marco Lucchi and Alfredo Mussi, et al. -- Radioguided Surgery of Occult Lesions in Patients with Thyroid Cancer / Domenico Rubello, Massimo Salvatori, Maria Rosa Pelizzo, Giuseppe Boni and Giuliano Mariani -- Radioguided Bone Lesion Localization / Gianpiero Manca, Giuliano Mariani and Lary A. Robinson.
  • v. 1, 1960.
    v. 1-.
    Status: Not Checked OutLane Catalog Record
    pt. 1. Theory -- pt. 2. Experiments -- pt. 3. Neutron Experiments.
  • 2006 Springer
    L.M. Portnoy.
  • 1979-
    edited by William L. Leonard.
    Status: Not Checked OutLane Catalog Record
    v. 1. 1500 Multiple choice questions and referenced, selected explanatory answers; plus pretest and post-test examinations.
  • 2014 Springer
    Philip Borg, Abdul Rahman Alvi, Nicholas Skipper, Christopher Johns.
    Three years after the publication of the first edition, Radiological Anatomy for FRCR Part 1 remains the best seller in its category based on its faithful representation of the examination. This second edition is designed to reflect the change in exam format introduced in spring 2013. It includes two new chapters as well as some new cases in the remaining chapters and tests. Under the new exam format, candidates will be presented with 100 cases, with a single question per case and a single mark for the correct answer. This book covers all core topics addressed by the exam in a series of tests and includes chapters focussing specifically on paediatric cases and normal anatomical variants. The answers to questions, along with explanations and tips, are supplied at the end of each chapter. Care has been taken throughout to simulate the exam itself. The book aims not to replace the already available literature on radiological anatomy but rather to complement it as a revision guide. It will help candidates to identify the level of anatomical knowledge expected by the Royal College of Radiologists.
  • 2011 Springer
    Philip Borg, Abdul Rahman Alvi.
    The new FRCR part 1 Anatomy examination comprises 20 cases/images, with five questions about each. The cases are labelled 01 to 20 and the five questions are labelled (a) to (e). The authors have set out to emulate this format by gathering 200 cases which, from their experience, are representative of the cases on which candidates will be tested. The book consists of 10 tests with 20 cases each, and 5 stem questions each. The answers, along with an explanation and tips, accompany each test at the end of the chapter. This will help candidates to identify the level of anatomical knowledge expected.
  • 2007 Springer
    Ramon Ribes, Pablo R. Ros.
  • 2006 Springer
    A.S. Devos, J.G. Blickman (eds.) ; with contributions by T. Berrocal ... [et al.] ; foreword by A.L. Baert.
  • 2014 Springer
    editor, Emilio Quaia.
    This book, now in its second edition, provides a comprehensive analysis of imaging of the kidneys, upper urinary tract, and ureters, covering the normal anatomy and anatomic variants as well as all renal and urinary system pathologies. The relevant imaging modalities are first discussed, with detailed description of their applications in the kidney and upper urinary tract. The entire spectrum of kidney pathologies is then presented in a series of detailed chapters with up-to-date references, high-quality images, informative schemes, and figures showing macroscopic and microscopic surgical and pathologic specimens. Chapters relating to the latest innovations in tumor ablation, vascular and nonvascular interventional procedures, and parametric and molecular imaging have been fully updated to reflect progress in these rapidly evolving fields. This book will be of great interest to all radiologists, oncologists, nephrologists, and urologists who are involved in the management of kidney pathologies in their daily clinical practice.
  • 2008 Springer
    V. Donoghue (ed.) ; with contributions by P.G. Bjørnstad ... [et al.]; foreword by A.L. Baert.
    Embryology and Anatomy of the Neonatal Chest / Stephanie Ryan -- Update on Clinical Management of Neonatal Chest Conditions / Anne Twomey -- Computed and Digital Radiography in Neonatal Chest Examination / Amaka C. Offiah -- Hyaline Membrane Disease and Complications of Its Treatment / Veronica Donoghue -- Transient Tachypnoea of the Newborn / Veronica Donoghue -- Meconium Aspiration / Catherine M. Owens -- Diagnostic Imaging of Neonatal Pneumonia / David Manson -- Antenatal Imaging of Chest Malformations / Laurent Garel -- Postnatal Imaging of Chest Malformations / Stephanie Ryan -- Congenital Anomalies of the Neonatal Upper Airway / David Manson -- Computed Tomography of the Central and Peripheral Airways / Alistair D. Calder and Catherine M. Owens -- Ultrasound of the Neonatal Thorax / Ingmar Gassner and Theresa E. Geley -- Ultrasound in Congenital Heart Disease / Colin J. McMahon and Benjamin W. Eidem -- Magnetic Resonance Imaging in Congenital Heart Disease / Christian J. Kellenberger -- Chest Radiography in Congenital Heart Disease / Bjarne Smevik -- Angiocardiography and Intervention in Congenital Heart and Great Vessel Disease / Bjarne Smevik and Per G. Bjørnstad -- Computed Tomography in Congenital Heart Disease / Laureen Sena and Hyun Woo Goo -- Chest Wall Abnormalities which Cause Neonatal Respiratory Distress / Georg F. Eich.
  • 2014 Springer
    edited by John Reidy, Nigel Hacking, Bruce McLucas.
    This book provides a state-of-the-art review of the technical and clinical aspects of the vascular interventional radiological (IR) procedures currently employed in obstetrics and gynaecology. A particular focus is on uterine artery embolisation for fibroid disease, which is contrasted with the main alternative uterus-conserving surgical approach of myomectomy, and with ablation therapy. Detailed consideration is also given to the role of embolisation in a variety of other less common conditions, including arteriovenous malformations, post-partum haemorrhage, abnormal placentation and pelvic congestion syndrome. IR procedures are examined from a critical gynaecological perspective and with regard to surgical alternatives. The authors include leading interventional radiologists and gynaecologists from the United Kingdom, Europe and North America. .
  • 2005 Springer
    editors: A. Kaul, D. Becker ; authors: D. Becker, G. Brix, A. Dalheimer, ... [et al.].
  • 2008 Springer
    Francesco Schiavon, Fabio Grigenti ; with a contribution by Nick van Terheyden, and the collaboration of Riccardo Berletti ... [et al.].
  • 2014 Springer
    Lawrence Lau, Kwan-Hoong Ng, editors.
    Radiological Safety and Quality - Paradigms in Leadership and Innovation is a multi-disciplinary and inter-sectorial collaboration by international experts and leaders from academic institutions, radiology practices, professional organizations, regulatory authorities, UN and international agencies. Established principles and new concepts, challenges and opportunities, and examples of leadership and innovations are discussed to raise awareness, share experience and facilitate development of facility-based or system-wide improvements in radiation safety, quality radiology, and patient care by procedure justification, optimization of protection and imaging data, and incident minimization. The 26 chapters by 53 experts and 11 messages from international organizations and agencies convey a common theme: there is no single panacea to improve radiological safety and quality but on-going leadership, innovation, collaboration, and stakeholder participation are needed.
  • 2013 Springer
    Alberto Tagliafico, Carlo Martinoli ; foreword by Lorenzo Derchi.
    Introduction -- Introduction / Antonio Zicca, Alberto Tagliafico -- Upper limb -- Shoulder / Erica Fisci, Alberto Tagliafico -- Elbow / Alberto Tagliafico, Carlo Martinoli -- Wrist / Alberto Tagliafico, Carlo Martinoli -- Lower limb -- Hip / Alberto Tagliafico, Erica Fisci, Carlo Martinoli -- Knee / Alberto Tagliafico, Carlo Martinoli -- Ankle / Bianca Bignotti, Carlo Martinoli, Alberto Tagliafico -- Spine -- Spine / Erica Fisci, Alberto Tagliafico
  • 2005 Springer
    Nicholas C. Gourtsoyiannis, Pablo R. Ros (eds.).
    Also available: Print – 2005
  • 2010
    editor, William E. Erkonen ; associate editor, Wilbur L. Smith.
    Status: Not Checked OutLane Catalog Record
    Radiography, computed tomography, magnetic resonance imaging, and ultrasonography : principles and indications / William E. Erkonen and Vincent A. Magnotta -- Chest / William E. Erkonen and Brad H. Thompson -- Abdomen / Edmund A. Franken, Jr. -- Pediatric imaging / Wilbur L. Smith -- Musculoskeletal system / William E. Erkonen and Carol A. Boles -- Spine and pelvis / Carol A. Boles --Brain / Wilbur L. Smith -- Head and neck / Yutaka Sato -- Nuclear imaging / David L. Bushnell, Jr. -- Breast imaging / Jeong Mi Park, William E. Erkonen, and Laurie L. Fajardo -- Interventional radiology / Thomas A. Farrell.
  • 2004- Get Password UCSF
    [editor], Henry I. Goldberg; contributors, Marcia McCowin, Steven Ross, Richard Breiman.
    1. Introduction -- 2. Diagnostic Imaging -- 3. Radiation Safety -- 4. X-rays and X-ray Tubes -- 5. Ultrasound -- 6. CT -- 7. MRI -- 8. Nuclear Medicine -- 9. Contrast Materials -- 10. Chest Overview -- 11. Cardiac -- 12. Abdomen -- 13. Acute Abdomen -- 14. Gastrointestinal Tract -- 15. Hepatobiliary System -- 16. Pancreas -- 17. Urinary Tract -- 18. Staging Cancer -- 19. Musculoskeletal -- 20. Severe Trauma Basics -- 21. Mammography -- 22. Interventional -- 23. Neuroradiology -- 24. Acute Care Chest -- 25. Midterm Quiz.
  • 2006 Springer
    by Amit Mehta, Douglas P. Beall.
    Musculoskeletal radiology -- Chest radiology -- Gastrointestinal radiology -- Genitourinary radiology -- Head and neck radiology -- Vascular and interventional -- Nuclear medicine -- Ultrasound -- Pediatrics -- Breast -- Neuroradiology.
  • 2008 ScienceDirect
    David M. Yousem, Norman J. Beauchamp Jr.
    Whether working in a private, group, hospital, and/or university setting, this practical resource delivers to the reader the real-world advice needed to effectively navigate day-to-day financial decisions, equipment and computer systems choices, and interactions with with partners and staff.
  • 2012 Springer
    edited by Kathryn M. Hibbert, Rethy K. Chhem, Teresa Deven, Shih-chang Wang.
    Part 1. Evaluation and Assessment for Non-educators -- The Nature of Professional Expertise / Penelope Engel-Hills and Rethy K. Chhem -- Fundamentals of Assessment and Evaluation: Clarifying Terminology / Kathryn M. Hibbert, Teresa Van Deven and Soveacha Ros -- Competence in the Professions: Expanding Opportunities and Emerging Practices / Kathryn M. Hibbert and Rethy K. Chhem -- Medical Competency in Postgraduate Medical Training Programs / Thomas N. B. Pascual, Soveacha Ros, Penelope Engel-Hills and Rethy K. Chhem -- Part 2. Evaluation and assessment in Radiology education -- Philosophical Considerations in Educational Assessment / Richard B. Gunderman -- Competencies and Experiential Requirements in Radiology Training / Shih-chang Wang -- Accreditation and Evaluation of Programs: The Canadian Perspective / Kenneth A. Harris, Margaret A. Kennedy and Sarah Taber -- Assessment and Evaluation in a Transnational Radiodiagnosis Training Program / Shih-chang Wang -- Part 3. Case Studies: Theory into practice -- Strategies and Actions to Improve Risk Communication Competency in Radiation Medicine / Lawrence S. Lau, Kwan-Hoong Ng and Rethy K. Chhem -- Assessing Clinical Competence in Radiation Oncology Education / Eduardo Rosenblatt, Bruce G. Haffty and Jan Willem Leer -- Measuring Competence of Radiology Education Programs and Residents: The Egyptian Experience / Sahar N. Saleem and Youssriah Y. Sabri -- Assessing Residents in a Nuclear Medicine Physician Training Program: The Philippine Experience / Thomas N. B. Pascual, Jerry M. Obaldo, Teofilo O. L. San Luis and Marcela J. Leus -- Clinical Training in Medical Physics: IAEA Perspective / Ahmed Meghzifene, Donald Mclean, Debbie Van Der Merwe and Brian Thomas -- Assessing Diagnostic Radiology Training: The Singapore Journey / Bien-Soo Tan, Lynette L. S. Teo, Daniel E. S. Wong, Shaun X. J. M. Chan and Kiang-Hiong Tay -- Assessment of Radiation Oncology Medical Physics Residents: The London, Ontario (Canada) Experience / Jacob Van Dyk and Jerry J. Battista.
  • 2009 Springer
    Rethy K. Chhem, Kathryn M. Hibbert, Teresa Van Deven (eds.).
    Introduction: Transforming radiology education through scholarship -- The genesis and application of radiology education: mind the gap -- Scholarship in radiology education -- Today's radiology student: what every radiology training program director needs to know -- Teaching and learning: defining the scholarship of teaching -- Interdisciplinary learning: a stimulant for reflective practice -- Feedback in radiologic education -- The role of mentoring in professional education -- Radiological and biomedical knowledge integration: the ontological way -- Educational insights about professional ethics in radiology -- Learning in practice: new approaches to professional development for radiologists -- Acquiring competencies in radiology: the canMEDS model -- Technologies for teaching: exploring the use of PACS, databases, and teaching files -- Portable imaging systems for interactive teaching of radiography, computed tomography and ultrasound imaging principles -- Medical education research: challenges and opportunities in the scholarship of discovery -- Developing a radiology curriculum for a new medical school in Singapore -- Leadership in radiology education -- The business of radiology education scholarship -- Radiology education in Southeast Asia: current status and pedagogical challenges -- Training of ultrasound doctors and educational reform in West China hospital of Sichuan University, China -- Teaching radiology at the Angkor hospital for children in Siem Reap, Cambodia -- Teaching radiology in Latin America: images from Peru -- Using the world wide web to develop competencies around the globe -- The role of a learned society in promotion and dissemination of knowledge -- Radiology education in the faculty of medicine at Cairo University (Kasr Al-Ainy hospital).
  • 2014 Springer
    Cristina Nanni, Stefano Fanti, Lucia Zanoni.
    Reading PET/CT scans is sometimes challenging. Not infrequently, abnormal findings on CT images are functionally silent and therefore difficult for nuclear medicine practitioners to interpret. Furthermore, in general only a low-dose CT scan is produced as part of the combined PET/CT study, and the resulting CT images may prove suboptimal for image interpretation. This atlas is designed to enable nuclear medicine practitioners who routinely read PET/CT scans to recognize the most common CT abnormalities. Slice-by-slice descriptions are provided of anatomical structures as visualized on CT scans obtained in PET/CT studies. The CT findings that may be detected while reviewing PET/CT scans of various body regions and conditions are then illustrated and fully described. The concluding section of the book is devoted to the principal MRI findings in diseases which cannot be evaluated using PETs/CTs.
  • 2008 Springer
    Evis Sala ... [et al.] ; foreword by Johannes Zacherl.
  • 2015 Springer
    edited by Harjit Singh, Janet A. Neutze, Jonathan R. Enterline.
    This book is a concise introduction to the dynamic field of radiology and provides readers with general examples and brief discussions of basic radiographic principles. Introductory chapters present fundamental scientific concepts underlying the medical use of imaging modalities and technology, including ultrasound, computed tomography, magnetic resonance imaging, and nuclear medicine. Subsequent chapters are organized by anatomic region and imaging modality that highlight the radiologist?s role in diagnosing and treating common disorders. This revised edition is thoroughly updated and includes new or expanded chapters on nuclear medicine and pediatric radiology. Radiology Fundamentals, Fifth Edition, is a premier self-directed learning resource for medical students, non-radiology housestaff, physician assistants, nurse practitioners, radiologist assistants and other allied health professionals.
  • 2012 Springer
    Harjit Singh, Janet A. Neutze, editors.
    Patient Radiation Safety and Risk -- Introduction to Radiology Concepts -- Conventional Radiology -- Ultrasound -- Computed Tomography -- MRI -- Nuclear Medicine -- Cardiovascular and Interventional Radiology -- Heart and Mediastinum -- Lateral Chest -- Pulmonary Mass Lesions -- Air Space Disease -- Interstitial Disease -- Atelectasis -- Pulmonary Vasculature -- Pulmonary Edema -- Pneumothorax -- Miscellaneous Chest Conditions -- Tubes and Lines -- Breast Imaging -- Women's Ultrasound -- Women's Health Interventions -- Abdominal Calcifications -- Abnormal Air Collections in the Abdomen -- Barium Studies of the Upper GI Tract -- Barium Enema & CT Colonography -- Bowel Obstruction -- Inflammatory Bowel Disease -- Defecography -- Intra-abdominal Lymphadenopathy -- The Gallbladder -- Abdominal & Pelvic Pain Evaluation -- Imaging of the Trauma Patient -- Concerning Lesions -- Incidental Lesions -- Radionucleotide Evaluation of GI Bleeding -- Radionucleotide Bone Imaging -- Lung Ventilation and Perfusion Imaging -- Radionucleotide Cardiac Imaging -- F-18 FDG Positron Emission Tomography -- Diagnostic Arteriography -- Pulmonary Arteriography & IVC Filter Placement -- Percutaneous Nephrostomy Placement -- TIPS -- Central Venous Access -- Fractures -- Part 1 -- Fractures -- Part 2 -- Arthritides -- Bone Tumor Characterstics -- CNS Anatomy -- The Cervical Spine -- Head Trauma -- Stroke -- Headache and back pain -- Radiology coming soon.
  • 2014 Springer
    Kyung Soo Lee [and three others].
    Illustrates how to achieve reliable diagnoses when confronted by the different abnormalities, or disease patterns, that may be visualized on CT scans of the chest.
  • 2015 Springer
    Byung Ihn Choi, editor.
    Part 1. Pharynx/Esophagus -- 1. Benign structural and functional abnormality of the esophagus, postop. Complication of the esophagus -- 2. Esophagitis -- 3. Benign and malignant tumor of the esophagus -- Part 2. Stomach/Duodenum -- 4. Benign structural & functional abnormality of the stomach and duodenum -- 5. Inflammatory and infectious diseases of the stomach and duodenum -- 6. Mucosal tumor of the stomach -- 7. Subepithelial tumor of the stomach -- 8. Lymphoma and metastasis of the stomach -- 9. Postoperative change and complications of the stomach and duodenum -- Part 3. Small Bowel -- 10. Benign structural & functional abnormality of the small bowel -- 11. Inflammatory disease of the small bowel -- 12. Vasculitis and ischemic bowel disease -- 13. Small bowel obstruction -- 14. Benign tumor of the small bowel -- 15. Malignant tumor of the small bowel -- Part 4. Colon -- 16. Benign structural & functional abnormality of the colon -- 17. Inflammatory & infectious disease of the colon -- 18. Benign tumor of the colon -- 19. Malignant tumor of the colon -- 20. Postoperative change and complications of the colon -- Part 5. Mesentery, Peritoneum, abdominal wall -- 21. Benign diseases of mesentery and omentum -- 22. Malignant diseases of mesentery and omentum -- 23. Abdominal wall abnormality & hernia.
  • 2012 Springer
    by Seung Hyup Kim.
    Part 1. Ultrasound and Transvaginal Ultrasound: Techniques, Normal Findings, and Variations. Introduction / Min Hoan Moon and Jung Sik Kim -- Illustrations / Min Hoan Moon and Jung Sik Kim -- pt. 2. Gynecologic CT and MRI: Techniques and Normal Findings. Introduction / Sung Il Jung and Bohyun Kim -- Illustrations / Sung Il Jung and Bohyun Kim -- pt. 3. Variations and Congenital Anomalies of the Female Genital Tract. Introduction / Jeong Kon Kim -- Illustrations / Jeong Kon Kim -- pt. 4. Uterine Myoma. Introduction / Byung Kwan Park -- Illustrations / Byung Kwan Park -- pt. 5. Adenomyosis. Introduction / Byung Kwan Park -- Illustrations / Byung Kwan Park -- pt. 6. Imaging Evaluation of Uterine Cervical Carcinoma. Introduction / Seung Hyup Kim and Kyung-Sik Cho -- Illustrations / Seung Hyup Kim and Kyung-Sik Cho -- pt. 7. Endometrial Cancer. Introduction / Sung Il Hwang and Seung Hyup Kim -- Illustrations / Sung Il Hwang and Seung Hyup Kim. pt. 8. Miscellaneous Tumors of the Uterus. Introduction / Yu Ri Shin and Sung Eun Rha -- Illustrations / Yu Ri Shin and Sung Eun Rha -- pt. 9. Post-treatment Changes and Recurrence of Uterine Malignancies. Introduction / Dae Chul Jung and Kie Hwan Kim -- Illustrations / Dae Chul Jung and Kie Hwan Kim -- pt. 10. Gestational Trophoblastic Diseases. Introduction / Jae Young Byun and Seung Eun Jung -- Illustrations / Jae Young Byun and Seung Eun Jung -- pt. 11. Miscellaneous Diseases of the Uterus. Introduction / Seung Eun Jung and Jae Young Byun -- Illustrations / Seung Eun Jung and Jae Young Byun -- pt. 12. Ovarian Cysts and Cystic Disease. Introduction / Hyuck Jae Choi -- Illustrations / Hyuck Jae Choi -- pt. 13. Ovarian Tumors: General Considerations and Mode of Spread. Introduction / Min Hoan Moon -- Illustrations / Min Hoan Moon -- pt. 14. Epithelial Tumors of the Ovary. Introduction / Sung Bin Park and Min Hoan Moon -- Illustrations / Sung Bin Park and Min Hoan Moon. pt. 15. Germ Cell Tumors of the Ovary. Introduction / Sun Ho Kim -- Illustrations / Sun Ho Kim -- pt. 16. Sex Cord-Stromal Tumors of the Ovary. Introduction / Jung Suk Sim -- Illustrations / Jung Suk Sim -- pt. 17. Miscellaneous Tumors of the Ovary and Adnexa. Introduction / Chang Kyu Sung and Jung Suk Sim -- Illustrations / Chang Kyu Sung and Jung Suk Sim -- pt. 18. Endometriosis. Introduction / Hyun Lee and Jeong Yeon Cho -- Illustrations / Hyun Lee and Jeong Yeon Cho -- pt. 19. Adnexal Torsion. Introduction / Sung Eun Rha and Young-Hwa Kim -- Illustrations / Sung Eun Rha and Young-Hwa Kim -- pt. 20. Pelvic Inflammatory Disease and Tubo-ovarian Abscess. Introduction / Jeong Yeon Cho -- Illustrations / Jeong Yeon Cho -- pt. 21. Ectopic Pregnancy. Introduction / Min Hoan Moon and Young-Ho Lee -- Illustrations / Min Hoan Moon and Young-Ho Lee. pt. 22. Vagina and Vulva. Introduction / Sun Ho Kim and Bohyun Kim -- Illustrations / Sun Ho Kim and Bohyun Kim -- pt. 23. Vascular Diseases of the Female Pelvis. Introduction / Seong Jin Park -- Illustrations / Seong Jin Park -- pt. 24. Pediatric Gynecologic Diseases. / Introduction / So-Young Yoo and Woo Sun Kim -- Illustrations / So-Young Yoo and Woo Sun Kim -- pt. 25. Nongynecologic Lesions Mimicking Gynecologic Diseases. Introduction / Bum Sang Cho and Seung Hyup Kim -- Illustrations / Bum Sang Cho and Seung Hyup Kim -- pt. 26. Hysterosalpingography. Introduction / Hak Jong Lee -- Illustrations / Hak Jong Lee -- pt. 27. Sonohysterography. Introduction / Eun Ju Lee -- Illustrations / Eun Ju Lee -- pt. 28. Gynecologic Nonvascular Interventions. Introduction / See Hyung Kim and Seung Hyup Kim -- Illustrations / See Hyung Kim and Seung Hyup Kim -- pt. 29. Obstetric and Gynecologic Vascular Interventions. Introduction / Man-Deuk Kim and Jin Wook Chung -- Illustrations.
  • 2014 Springer
    Byung Ihn Choi, editor.
    Radiology Illustrated: Hepatobiliary and Pancreatic Radiology is the first of two volumes that will serve as a clear, practical guide to the diagnostic imaging of abdominal diseases. This volume, devoted to diseases of the liver, biliary tree, gallbladder, pancreas, and spleen, covers congenital disorders, vascular diseases, benign and malignant tumors, and infectious conditions. Liver transplantation, evaluation of the therapeutic response of hepatocellular carcinoma, trauma, and post-treatment complications are also addressed. The book presents approximately 560 cases with more than 2100 carefully selected and categorized illustrations, along with key text messages and tables, that will allow the reader easily to recall the relevant images as an aid to differential diagnosis. At the end of each text message, key points are summarized to facilitate rapid review and learning. In addition, brief descriptions of each clinical problem are provided, followed by both common and uncommon case studies that illustrate the role of different imaging modalities, such as ultrasound, radiography, CT, and MRI.
  • 2014 Springer
    In-One Kim, editor.
    This case-based atlas presents images depicting the findings typically observed when imaging a variety of common and uncommon diseases in the pediatric age group. The cases are organized according to anatomic region, covering disorders of the brain, spinal cord, head and neck, chest, cardiovascular system, gastrointestinal system, genitourinary system, and musculoskeletal system. Cases are presented in a form resembling teaching files, and the images are accompanied by concise informative text. The goal is to provide a diagnostic reference suitable for use in daily routine by both practicing radiologists and radiology residents or fellows. The atlas will also serve as a teaching aide and a study resource, and will offer pediatricians and surgeons guidance on the clinical applications of pediatric imaging.
  • 2014 Springer
    Heung Sik Kang, Joon Woo Lee, Jong Won Kwon.
    Radiology Illustrated: Spine is an up-to-date, superbly illustrated reference in the style of a teaching file that has been designed specifically to be of value in clinical practice. Common, critical, and rare but distinctive spinal disorders are described succinctly with the aid of images highlighting important features and informative schematic illustrations. The first part of the book, on common spinal disorders, is for radiology residents and other clinicians who are embarking on the interpretation of spinal images. A range of key disorders are then presented, including infectious spondylitis, cervical trauma, spinal cord disorders, spinal tumors, congenital disorders, uncommon degenerative disorders, inflammatory arthritides, and vascular malformations. The third part is devoted to rare but clinically significant spinal disorders with characteristic imaging features, and the book closes by presenting practical tips that will assist in the interpretation of confusing cases.
  • 2012 Springer
    Seung Hyup Kim, editor.
    Uroradiology is an up-to-date, image-oriented reference in the style of a teaching file that has been designed specifically to be of value in clinical practice. All aspects of the imaging of urologic diseases are covered, and case studies illustrate the findings obtained with the relevant imaging modalities in both common and uncommon conditions. Most chapters focus on a particular clinical problem, but normal findings, congenital anomalies, and interventions are also discussed and illustrated.In this second edition, the range and quality of the illustrations have been enhanced, and many schematic drawings have been added to help readers memorize characteristic imaging findings through pattern recognition. The accompanying text is concise and informative. Besides serving as an outstanding aid to differential diagnosis, this book will provide a user-friendly review tool for certification or recertification in radiology.
  • 2014 Springer
    D.J. Mollura, Matthew P. Lungren, editors.
    "The only book of its kind to prepare radiology residents interested in working on global health service projects in the developing world Includes information on designing, testing, and deploying clinical strategies adapted for regions with limited resources Presents information technology models to support digital imaging in the developing world This book is designed to increase awareness of the global health problem of lack of access to medical imaging services and presents solutions to overcome disparities in the delivery of radiologic services to the developing world. Featuring an interdisciplinary framework, it discusses economic strategies for sustainable radiology; public health radiology for population-based approaches; clinical model formulation tailored to needs and resources of regions and communities; technology innovation and optimization; and public policy for healthcare system development at the government and international institutional level. It explores the role of radiology in addressing health care disparities and highlights strategies for radiology services planning and implementation in low resource settings. It also provides an overview of the clinical role of medical imaging in the developing world, including epidemiology, disaster response, and specific clinical applications for recognizing and managing illnesses unique to the developing world. Radiology in Global Health: Strategies, Implementation, and Applications examines ways to achieve sustainable long-term imaging strategies for limited resource regions and is a valuable resource for radiologists, radiology residents, radiology technologists, physicians, nurses, and healthcare administrators"--Provided by publisher.
  • 2007 Thieme Book
    Sebastian Lange, Geraldine Walsh ; with a contribution by Michael Montag.
    Concise, systematic atlas to thoracic radiology emphasizing computed tomography. Includes a new chapter on cardiac imaging. For practitioners. Translated from the 3rd German edition: Radiologische Diagnostik der Thoraxerkrankungen, c2005. Halftone and color images and illustrations.
  • 2014 Springer
    Li, Hongjun.
    Molecular Biology of HIV/AIDS and Its Clinical Management -- An Overview of Clinical Immunology of HIV/AIDS -- An Overview of Clinical Microbiology of HIV/AIDS -- Epidemiological Investigation of AIDS -- Pathogenetic and Pathological Mechanism -- Clinical Manifestations of HIV/AIDS Infection -- Laboratory Test and Special Examinations -- Diagnostic Imaging -- AIDS Imaging and Evidence Based Medicine -- Clinical Medication Against HIV/AIDS -- Introduction to Assessment and Monitoring of Critical AIDS -- HIV Related Effect Factors -- HIV/AIDS Related Nervous System Diseases -- HIV/AIDS Related Myeleterosisand Peripheral Neuropathy -- HIV/AIDS Related Eye Diseases -- HIV/AIDS Related Neck Diseases -- HIV/AIDS Related Respiratory Diseases -- HIV/AIDS Related Cardiac Diseases -- HIV/AIDS Related Gastrointestinal Diseases -- HIV/AIDS Related Hepatobiliary, Pancreatic and Splenic Diseases -- HIV/AIDS Related Peritoneal and Retroperitoneal Disease -- HIV/AIDS Related Urogenital Disease -- HIV/AIDS Related Musculoskeletal Diseases -- HIV/AIDS Related Pediatric Diseases -- HIV/AIDS Related Skin Diseases -- Functional Imaging of HIV/AIDS.
  • v.1-2=, 2015 Springer
    vol. 2 Springer
    Hongjun Li, editor.
  • 2013 Springer
    Hongjun Li, Ning Li, editors.
    A novel strain of influenza A (H1N1) virus emerged and an outbreak of influenza A (H1N1) occurred worldwide in 2009 and 2010, posing a severe threat to the health of human beings. The two Editors work together in Beijing You An Hospital, to combat this type of influenza. This book, Radiology of Influenza A (H1N1), is intended to provide first-hand clinical data and its scientific analysis, thus supporting sound clinical practice for influenza A (H1N1) prevention and treatment as well as related scientific research. The authors have collected over 100 critical influenza A (H1N1) virus-infected cases. For cases of influenza A (H1N1) that resulted in death, autopsies were performed for 8 cases after receiving their families' informed consent. Over 200 reports on pathological and histological analysis as well as immunohistochemical and electroscopic analysis were brought together. This book was then compiled by comparing the published data with the present first-hand data. This book includes a wealth of content, including DR, CT and MRI images, pathological and histological figures, and immunohistochemical and electroscopic figures. Related research, clinical and educational needs can be readily satisfied by its detailed data, texts and figures, as well as typical case reports. Li Hongjun, is professor and director of the diagnostic radiology department in Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China. Li Ning, is professor and president of Beijing You An Hospital, affiliated with Capital Medical University, Beijing, China.
  • 2011 Springer
    by Mubin I. Syed and Azim Shaikh.
    Introduction to radiology -- Head and neck -- Thorax -- Abdomen -- Pelvis -- Extremities: general overview -- Upper extremity -- Lower extremity.
  • 2008 Springer
    S. Grampp (ed.) ; with contributions by J.E. Adams ... [et al.] ; foreword by A.L. Baert.
  • 2010 ClinicalKey
    Jonathan J. Dutton.
    "Dr. Jonathan J. Dutton, a world leader in orbital surgery, presents Radiology of the Orbit and Visual Pathways. This new and unique diagnostic guide offers expert advice on the full spectrum of uses of CT and MRI, the two core methods of radiologic imaging of the orbit. An atlas style approach provides the essential text you need to accurately diagnose over 120 of the more common disorders you'll come across in your daily routine, and over 1,100 lavish illustrations enhance your visual guidance. Covering the entire visual pathways from the eye to the occipital cortex, you'll gain thorough knowledge of normal anatomy and how it compares to pathologic findings to confidently diagnose. Plus, with Expert Consult functionality, you'll have easy access to the full text online, as well as all of the book's illustrations at expertconsult.com."--Publisher's website.
  • 2012 Springer
    John Brittenden, Damian J.M. Tolan, editors.
    Introduction to the Post Surgical Abdomen / Alan G. Chalmers, David Macafee, Damian J. M. Tolan and John Brittenden -- The Esophagus / Damian J. M. Tolan, Keith M. Harris, Deepak Prasad and Samir P. Mehta -- The Stomach and Duodenum / Damian J. M. Tolan, Keith M. Harris, Deepak Prasad and Samir P. Mehta -- The Pancreas / Krishna Menon, John Brittenden, Simon McPherson, Nikhil M. Bhuskute and Andrew Smith -- The Biliary Tree / Vamshi P. Jagadesham, Maria Sheridan, J. Peter A. Lodge and John Brittenden -- The Liver / J. Ashley Guthrie, Hajamohideen M. Salahudeen and J. Peter A. Lodge -- The Small Bowel / James C. Lenton, Adeshina S. Fawole, John Brittenden and Damian J. M. Tolan -- The Colon / Chris Macklin, John Brittenden, David Jayne and Damian J. M. Tolan -- Genitourinary System / Christopher Wilkinson.
  • 2008 Springer
    A.H. Freeman, E. Sala (eds.) ; with contributions by K. Balan ... [et al.] ; foreword by A.L. Baert.
  • 2015
    Curtis P. Langlotz.
    Status: Not Checked OutLane Catalog Record
    Chapter 1. Perfect pictures, imperfect prose -- Chapter 2. Expressing an imaging observation -- Chapter 3. Radiology reporting best practices -- Chapter 4. A guide to reporting style -- Chapter 5. Mastering speech recognition -- Chapter 6. Organizing the radiology report -- Chapter 7. The history of radiology reporting -- Chapter 8. Toward structured reporting -- Chapter 9. Standard terminology for the radiology report -- Chapter 10. How to think about imaging information -- Chapter 11. Decision making for diagnostic imaging -- Chapter 12. The future of radiology reporting -- References -- Index -- Disclosures -- Acknowlegments.
  • 2011 Ovid
    Wolfgang Dähnert, M.D., Department of Radiology, Aurora BayCare Medical Center, Green Bay, Wisconsin.
    "The book describes the disease entities, radiologic symptoms., as well as lists of differential diagnosis"--Provided by publisher.
  • 2007 Ovid
    Wolfgang Dähnert.
    Also available: Print – 2007
  • 2006
    [edited by] E. Scott Pretorius, Jeffrey A. Solomon.
    Status: Not Checked OutLane Catalog Record
  • E.Scott Pretorius, Jeffrey A.Solomon.
    Status: Not Checked OutLane Catalog Record
  • 2011 ClinicalKey
    [edited by] E. Scott Pretorius, Jeffrey A. Solomon.
    Also available: Print – 2011
  • 2012 Springer
    Ignac Fogelman, Gopinath Gnanasegaran, Hans van der Wall, editors.
  • 2007 CRCnetBASE
    edited by Michael Poschl, Leo M.L. Nollet.
  • 2013 Springer
    Elena Lazzeri [and others] ; forewords by Christopher J. Palestro and Giovanni Lucignani.
    This atlas fills a gap in the literature by documenting in detail the role of nuclear medicine imaging of infection and inflammation. The pathophysiologic and molecular mechanisms on which radionuclide imaging of infection/inflammation is based are clearly explained, but the prime focus of the book is on the clinical relevance of such procedures. Their impact is demonstrated by a collection of richly illustrated teaching cases that describe the most commonly observed scintigraphic patterns, as well as anatomic variants and technical pitfalls. Due attention is paid to the application of recently developed techniques, including multimodality fusion imaging such as SPECT/CT and PET/CT. Emphasis is placed in particular on the ability of multimodality imaging to increase both the sensitivity and the specificity of radionuclide imaging. This atlas will be an excellent learning tool for residents in nuclear medicine and illuminating for other specialists with an interest in the field. Learning tool especially useful for residents in nuclear medicine and for specialists in nuclear medicine approaching the field. Useful integration for residents and for specialists also in infectious and autoimmune diseases, as well as in orthopedics.
  • 2011 CRCnetBASE
    Lawrence E. Williams.
    "This comprehensive overview details the process of radiopharmaceutical development, from cellular studies to animal experiments to the design and implementation of clinical trials. It examines the relative benefits of various radiopharmaceuticals and provides guidance on dose estimation and agent selection. Utilizing figures of merit for quantitative assessment, it covers standard medical internal radiation dose (MIRD), absorbed dose method for imaging agents, vivo methods for obtaining activity data, errors of activity estimation techniques, phantom-based and patient-based dose estimates and their associated uncertainties, and options available to clinical physicists. Supported by numerous examples from clinical trials, it discusses two and three dimensional estimation processes, including modern hybrid scanners such as SPECT/CT and PET/CT"--Provided by publisher.
  • 2007 Karger
    volume editors, G.T. Szeifert ... [et al.].
  • 2011 Springer
    Lena Specht, Joachim Yahalom (editors).
  • 2008 Springer
    M.H. Seegenschmiedt, H.-B. Makoski, K.-R. Trott, L.W. Brady (eds.).
  • 2015 Springer
    Hans Geinitz, Mack Roach III, Nicholas van As, editors.
    Imaging, delineation and immobilization: MRI and MR-spectroscopy -- PET imaging in prostate cancer -- Phase contrast X-ray imaging- next generation CT imaging -- Organ contouring for IMRT -- General aspects of patient immobilization -- Internal immobilization: From rectal balloon to hyaluronic acid -- Clinical endpoints: Biochemical recurrence? a valuable endpoint? -- Overall and disease-free survival ? too long to wait? -- Late toxicity ? current scoring concepts -- Quality of life: Assessment and Correlates -- Dose escalation and new radiation techniques: Dose escalation ? an update on randomized clinical trials -- IMRT for prostate cancer -- IGRT- how and when -- Tracking in prostate cancer -- Locally advanced disease: Techniques of pelvic lymphatic irradiation -- Prophylactic treatment of the pelvic lymphatics: pro -- Prophylactic treatment of the pelvic lymphatics: contra -- Hormonal therapy and radiation therapy -- randomized and prospective trials -- Treatment of clinically involved lymph nodes -- Hypofractionation: Hypofractionation in prostate cancer- biological aspects -- Hypofractionation: Clinical data -- Simultaneous integrated boost techniques -- Brachytherapy: Principals of 3D, highly conformal brachytherapy -- Seed implantation -- HDR brachytherapy -- Adjuvant treatment and salvage treatment: Target volume definition in postoperative radiotherapy -- Randomized trials for adjuvant radiotherapy -- Salvage radiotherapy after radical prostatectomy -- Salvage prostatectomy after radiotherapy -- Use of protons and heavy ions: Proton therapy for prostate cancer: technological and clinical aspects -- There is evidence for the superiority of protons or heavy ions, pro -- There is evidence for the superiority of protons or heavy ions, contra. .
  • 2006 CRCnetBASE
    Graham Lappin, Simon Temple.
    Radiotracers and drug registration -- Radioactivity and radiotracers -- The study of drug metabolism using radiotracers -- DNA binding, isotope dilution and other uses of radiotracers -- Quantitative whole-body autoradiography (QWBA) -- Scintillation counting -- Statistics in liquid scintillation counting -- Instrumentation for detection of radioactivity -- Sample preparation for liquid scintillation counting -- Biomedical accelerator mass spectrometry -- Positron emission tomography -- Gamma scintigraphy and SPECT.
  • Bruce A. Tate, Lance Carlson, and Curt Hibbs.
  • 2011 Springer
    K.-D. Wolff, F. Hölzle.
    Radial Forearm Flap -- Lateral Arm Flap -- Anterolateral Thigh / Vastus Lateralis Flap -- Latissimus Dorsi Flap -- Scapular Flap -- Fibular Flap -- Klaus-Dietrich Wolff and Frank Hölzle -- Iliac Crest Bone Flap -- Perforator Flaps -- Anterolateral Thigh Perforator Flap -- Soleus Perforator Flap -- Deep Inferior Epigastric Artery Perforator Flap.
  • 2008
    [edited by], Honorio T. Benzon ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • 2008 Springer
    by Monica Baia, Simion Astilean, Traian Iliescu.
  • 2012 Springer
    edited by William S. Spielman, Narayanan Parameswaran.
    Introduction to RAMPs / Narayanan Parameswaran and William S. Spielman -- RAMPs and CGRP receptors / James Barwell ... [et al.] -- Regulation of GPCR trafficking by RAMPs / Jennifer M. Bomberger, Narayanan Parameswaran, and William S. Spielman -- Regulation of calcium sensing receptor trafficking by RAMPs / Tristan Bouschet, Støphane Martin, and Jeremy M. Henley -- Understanding RAMPs through genetically engineered mouse models / Mahita Kadmiel, Kimberly L. Fritz, and Kathleen M. Caron -- RAMPs as drug targets / Patrick M. Sexton ... [et al.] -- RAMP like proteins : RTP and reep family of proteins / Joel Mainland and Hiroaki Matsunami -- Regulation of RAMP expression in diseases / Asha Jacob, Rongqian Wu, and Ping Wang -- Perspectives on some recent studies on RAMPs / Narayanan Parameswaran and William S. Spielman.
    Also available: Print – 2012
  • 2012 CRCnetBASE
    edited by Isabelle Boutron, Philippe Ravaud, David Moher.
    "Nonpharmacological treatments include a wide variety of treatments such as surgery, technical procedures, implantable devices, nonimplantable devices, rehabilitation, psychoteherapy, and behavioral interventions. This book focuses on the methods of assessing nonpharmacological treatments, highlighting specific issues and discussing all possible design of trials. It provides practical examples to underline the issues and solutions in assessing nonpharmacological treatment in trials. Arguably the first book to exclusively explore this topic, it discusses various categories of treatments from surgical procedures to psychotherapy"--Provided by publisher.
  • 2013 CRCnetBASE
    Sin-Ho Jung.
    In cancer research, a traditional phase II trial is designed as a single-arm trial that compares the experimental therapy to a historical control. This simple trial design has led to several adverse issues, including increased false positivity of phase II trial results and negative phase III trials. To rectify these problems, oncologists and biostatisticians have begun to use a randomized phase II trial that compares an experimental therapy with a prospective control therapy.
  • 2016 ClinicalKey
    H.P. Rang, J.M. Ritter, R.J. Flower, G. Henderson.
    What is pharmacology? -- How drugs act : general principles -- How drugs act : molecular aspects -- How drugs act : cellular aspects, excitation, contraction and secretion -- Cell proliferation, apoptosis, repair and regeneration -- Cellular mechanisms : host defence -- Method and measurement in pharmacology -- Absorption and distribution of drugs -- Drug metabolism and elimination -- Pharmacokinetics -- Individual variation, pharmacogenomics and personalised medicine -- Chemical mediators and the autonomic nervous system -- Cholinergic transmission -- Noradrenergic transmission -- 5-Hydroxytryptamine and the pharmacology of migraine -- Purines -- Local hormones 1 : histamine and the biologically active lipids -- Local hormones 2 : peptides and proteins -- Cannabinoids -- Nitric oxide and related mediators -- The heart -- The vascular system -- Atherosclerosis and lipoprotein metabolism -- Haemostasis and thrombosis -- Haemopoietic system and treatment of anaemia -- Anti-inflammatory and immunosuppressant drugs -- Skin -- Respiratory system -- The kidney and urinary system -- The gastrointestinal tract -- The control of blood glucose and drug treatment of diabetes mellitus -- Obesity -- The pituitary and the adrenal cortex -- The thyroid -- The reproductive system -- Bone metabolism -- Chemical transmission and drug action in the central nervous system -- Amino acid transmitters -- Other transmitters and modulators -- Neurodegenerative diseases -- General anaesthetic agents -- Analgesic drugs -- Local anaesthetics and other drugs affecting sodium channels -- Anxiolytic and hypnotic drugs -- Antiepileptic drugs -- Antipsychotic drugs -- Antidepressant drugs -- CNS stimulants and psychotomimetic drugs -- Drug addiction, dependence and abuse -- Basic principles of antimicrobial chemotherapy -- Antibacterial drugs -- Antiviral drugs -- Antifungal drugs -- Antiprotozoal drugs -- Anthelmintic drugs -- Anticancer drugs -- Harmful effects of drugs -- Lifestyle drugs and drugs in sport -- Biopharmaceuticals and gene therapy -- Drug discovery and development.
  • 2012 ClinicalKey
    H P Rang, M M Dale, J M Ritter, R J Flower and G Henderson.
    This edition sets out a clear route through pharmacology for the reader, from a molecular understanding of receptors and drug actions to the clinical use of the most important groups of drugs. It contains everything students need to know about pharmacology in their early years.
  • 2007
    H.P. Rang, M.M. Dale, J.M. Ritter, R.J. Flower.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    Eric S. Rovner, Michelle E. Koski, editors.
    This volume provides practitioners with a practical, easy to read, well organized approach to the performance and analysis of urodynamics in order to optimize their usage clinically. Chapters are structured around specific types of patterns seen on urodynamic tracings. These urodynamic tracings are annotated and fully interpreted by the authors. Multiple examples of each type of tracing are provided with expert commentary. The expert commentary expands on the potential clinical significance of the tracing, provides a differential diagnosis, and, where appropriate, discusses its importance diagnostically, prognostically and the implications for clinical management. The text contains chapters on virtually all the relevant urodynamic findings and clinical conditions seen in practice, including lower urinary tract conditions in both adults and children, neurogenic and non-neurogenic dysfunction, and other commonly seen conditions such as lower urinary tract obstruction, vaginal prolapse, and detrusor overactivity. The material is also presented in a practical manner, with special consideration to the latest national and international guidelines. Written by authorities in the field, Rapid and Practical Interpretation of Urodynamics is a valuable resource that fills a key gap by providing a systematic method of interpretation of urodynamic tracings in an easy to understand textbook that will benefit urologic trainees and experienced urologists alike.
  • 2005 ScienceDirect
    Karen Holtzblatt, Jessamyn Burns Wendell, Shelley Wood.
  • 2008 Springer
    M. Gabriel Khan ; with a foreword by Christopher P. Cannon.
    Also available: Print – 2008
  • 2014 ebrary
    Shona Ross and Sarah Furrows.
    The Rapids are a series of reference and revision pocket books that cover key facts in a simple and memorable way. Each book contains the common conditions that students and newly qualified nurses encounter on the wards, in the community, and on placements. Only the basic core relevant facts are provided to ensure that these books are perfect and concise rapid refreshers. Rapid Infection Control Nursing is an essential read for all frontline nursing staff working in hospitals or community settings. Designed for quick reference, it explores the essential principles of infection.
  • 2007 ClinicalKey
    David Rolston, Craig Nielson.
    Neurology -- Ophthalmology -- Otorhinolaryngology -- Pulmonology -- Cardiology -- Gastroenterology -- Psychiatry -- Rheumatology -- Orthopedics -- Dermatology -- Endocrinology -- Urology -- Obstetrics and gynecology -- Hematology and oncology -- Preventive medicine and misc topics -- Emergency medicine -- Pediatrics -- Surgery -- Radiology -- Infectious disease.
  • 2008 ClinicalKey
    Edward F. Goljan, Karlis I. Sloka.
    Laboratory test interpretation -- Electrolyte and acid-base disorders -- Pulmonary function tests -- Renal function tests -- Red blood cell disorders -- White blood cell disorders -- Hemostasis disorders -- Immunohematology -- Clinical chemistry -- Endocrine testing -- Body fluid analysis -- Clinical immunopathology.
  • 2011 ClinicalKey
    Ken S. Rosenthal, Michael J. Tan.
    "Get the most from your study time, and experience a realistic USMLE simulation with Rapid Review Microbiology and Immunology, 3rd Edition, by Drs. Ken S. Rosenthal and Michael J. Tan. This new reference in the highly rated Rapid Review Series is formatted as a bulleted outline with photographs, tables and figures that address all the microbiology and immunology information you need to know for the USMLE. And with Student Consult functionality, you can become familiar with the look and feel of the actual exam by taking a timed or a practice test online that includes 400 USMLE-style questions."--Publisher's website.
  • 2014 ClinicalKey
    Edward F. Goljan.
    This book is by Edward F. Goljan, MD, makes it easy for you to master all of the pathology material covered on the USMLE Steps 1 and 2. It combines an updated outline-format review of key concepts and hundreds of full-color images and margin notes, PLUS more than 400 USMLE-style online questions! Get all the practice you need to succeed on the USMLEs! New to this edition: Visualize key pathologic concepts and conditions with over 1,000 full-color images, completely reviewed and updated for this new edition.
  • 2012
    Hattie Zhi Chen Dong.
    Visualization of the blood vessel anatomy and the measurement of information related to blood flow play a crucial role in the diagnosis of cardiovascular diseases. Magnetic resonance imaging (MRI) is an especially attractive modality for this purpose because of its ability to provide morphological as well as flow-related information in one exam. Despite technological advances, vascular imaging with MRI is still limited by long scan times, which lead to image artifacts, patient discomfort, and high costs. Novel vascular MRI techniques are proposed in this dissertation that greatly reduce scan times compared to conventional methods (scan times on the order of seconds vs. minutes), while achieving similar image information content. First, an ungated Fourier velocity encoding (FVE) method is introduced for quantitating blood velocities in a few seconds. Accurate quantitation of the peak blood flow velocity can play an important role in assessing the severity of cardiovascular diseases. Next, a non-contrast-enhanced (NCE) magnetic resonance angiography (MRA) technique that provides high-contrast renal angiograms in as short as one heartbeat is developed for imaging renal artery stenosis. NCE MRA generates vessel contrast without the aid of external agents, making it the more comfortable, safer and lower cost alternative to traditional contrast-enhanced MRA. Lastly, an abdominal NCE MRA method for imaging the abdominopelvic arteries within a breath-hold is presented. Extending arterial vessel visualization from the renal region to the entire abdominal region enables the diagnosis of peripheral arterial disease in addition to renal artery stenosis.
  • 1955.
    rédacteur: Alfred Dumont.
    [1] Diagnostic et traitement des hémorragies digestives aiguës / par Fr. Moyson et A. de Scoville avec la collaboration de S. Godart ... [et al.].
  • 2011 Springer
    Nicholas Reed, John Alan Green, David M. Gershenson, Nadeem Siddiqui, Rachel Connor (editors).
    Epidemiology and databases -- Rare and uncommon gynecological cancers: a clinical guide -- The contribution of diagnostic imaging in rare gynecological malignancies -- Mucinous cancers: ovary -- Pseudomyxoma peritonei -- Ovarian clear cell carcinoma -- Clear cell carcinoma of the ovary -- The continuum of serious ovarian tumors of low malignant potential and low-grade serous carcinoma of the ovary -- Sex cord-stromal tumors -- Squamous cell carcinomas arising from dermoids -- Ovarian carcinosarcomas -- Small cell and neuroendocrine cancers of the ovary -- Primary ovarian carcinoids and neuro-endocrine tumors including struma ovarii -- Reed uterine carcinosarcomas -- Leiomyosarcomas of uterus -- Mucinous tumors of the uterine corpus -- Clear cell cancers of uterus -- Small cell and neuroendocrine cancers of the cervix -- Primary malignant melanoma of the vulva and vagina -- Gynecologic cancers in pregnancy: guidelines of an international consensus meeting.
  • 2015 Springer
    Mohamed A. Baky Fahmy.
    Patients with rare diseases, affecting less than 1 in 2000 persons, frequently experience delays or errors in diagnosis, sometimes with tragic consequences. Even after the diagnosis has been established, the quality of health care delivered is often poor. This book, which is both textbook and atlas, covers the full range of rare congenital genitourinary anomalies encountered in males and females, many of which have previously been described only in sporadic case reports. In the case of the more established anomalies, variants are presented. For each anomaly, information is provided on incidence, similar cases, clinical presentation, diagnosis, possible management and outcome. Informative supporting illustrations are presented for each anomaly, and the book will serve as an excellent reference for all pediatricians, urologists and surgeons who are responsible for the care of such patients.
  • 2010 Springer
    Manuel Posada de la Paz, Stephen C. Groft, editors.
    Rare diseases-avoiding misperceptions and establishing realities : the need for reliable epidemiological data / Stephen C. Groft and Manuel Posada de la Paz -- Rare diseases epidemiology research / Manuel Posada de la Paz ... [et al.] -- Evidence-based medicine and rare diseases / Simon Day -- Prevention, diagnosis, and services / Eva Bermejo and María Luisa Martínez-Frías -- The importance of case reports in advancing scientific knowledge of rare diseases / John C. Carey -- Patient registries : utility, validity, and inference / Rachel Richesson and Kendra Vehik -- Biobanking in rare disorders / Hanns Lochmüller and Peter Schneiderat -- Evaluation of the validity and utility of genetic testing for rare diseases / Scott D. Grosse, Lisa Kalman, and Muin J. Khoury -- Population-based surveillance for rare congenital and inherited disorders : models and challenges / Jodi M. Jackson, Krista S. Crider, and Richard S. Olney -- Statistical methods for the geographical analysis of rare diseases / Virgilio Gómez-Rubio and Antonio López-Quílez -- Clinical trials and rare diseases / Joachim Werner Otto Gerss and Wolfgang Köpcke -- A regulatory overview about rare diseases / Jordi Llinares -- Economic considerations in the provision of treatments for rare diseases / Christopher McCabe, Richard Edlin, and Jeff Round -- Rare diseases social epidemiology : analysis of inequalities / Anna Kole and François Faurisson -- Quality of life and rare diseases / Luis Rajmil, Lilisbeth Perestelo-Pérez, and Michael Herdman -- Cost of illness and economic evaluation in rare diseases / Julio López-Bastida and Juan Oliva-Moreno -- The burden of rare cancers in Europe / Gemma Gatta ... [et al.] -- Hereditary channelopathies in neurology / Karin Jurkat-Rott ... [et al.] -- Osteochondral diseases and fibrodysplasia ossificans progressiva / Antonio Morales-Piga and Frederick S. Kaplan -- The prevalence of congenital anomalies in Europe / Helen Dolk, Maria Loane, and Ester Garne -- Rare autoimmune diseases / Arrigo Schieppati and Erica Daina -- Epidemiology of rare anaemias in Europe / Beatrice Gulbis ... [et al.] -- Inherited metabolic rare disease / Teresa Pampols -- The contribution of rare diseases to understanding the epidemiology of neurodevelopmental disabilities / Diana Schendel, Catherine Rice, and Christopher Cunniff -- Creating a European Union framework for actions in the field of rare diseases / Antoni Montserrat Moliner -- National plans and strategies on rare diseases in Europe / Domenica Taruscio, Luciano Vittozzi, and Rumen Stefanov -- Ethical aspects on rare diseases / Luis A. Barrera and Gilberto Cely Galindo -- Advocacy groups and their role in rare diseases research / Mary Dunkle, Wayne Pines, and Peter L. Saltonstall.
    Also available: Print – 2010
  • 2015 Springer
    Meral Özgüc̦, editor.
    This book focuses on predictive, preventative and personalised medicine (PPPM) and how it is related to the healthcare of rare diseases. Readers will discover how advanced rare diseases healthcare provides an excellent "proof-of-principles" for the personalisation of healthcare systems on a global scale. Chapters look at national plans for rare disease, at biobanking, gene identification, rare cancers, virus gene therapy, induced pluripotency for cell therapy amongst other topics. There is a chapter dedicated to personalised medicine for hereditary deafness, and another exploring the complexity of genotype-phenotype correlations. Specific diseases such as Fabry's, Gauchers and mitochondrial cytopathies are highlighted and we look at enzyme replacement therapy in lysosomal storage diseases. This work is part of a series, produced with the involvement of the European Association for Predictive, Preventive and Personalised Medicine. The series focusses on the concept of an integrative medical approach by PPPM. This volume is dedicated to all aspects related to the prediction, prevention and personalised treatments of rare diseases, and in doing so it explores developments relevant to all medical branches. The authors cover ethical considerations, the creation of a robust platform for professional communication, synergies with patient organisations, "doctor-patient" collaboration and a new philosophy of integrative medicine by PPPM. This volume serves as a reference source for scientific and medical centres in the field and can be used both at medical curricula and graduate level in the life sciences. Those who place a special emphasis on healthcare promotion and innovations intended to combat rare diseases, save the affected lives and enhance life quality will all find this book of great value.
  • 2016 Springer
    edited by Lance Pagliaro.
    Rare Genitourinary Tumors offers the reader an up-to-date discussion of the less common neoplasms affecting the urinary tract and reproductive organs. Each authoritative chapter provides and in-depth discussion that is frequently not found in other urologic oncology textbooks. A valuable reference for urologists, oncologists, and those in specialty training, this volume provides ready access to information on etiology, incidence, risk factors, diagnosis, prognosis, insights from molecular pathology and, where applicable, data from clinical trials. The practical treatment guidelines included for each tumor type are written by experts and fully referenced.
  • 2008 Springer
    Stephen M. Ansell, editor.
    Also available: Print – 2008
  • 2016 Springer
    Gabriella Pichert, Chris Jacobs, editors.
    Advances in genetic testing for cancer predisposing genes -- Diagnosis and management of inheritable pheochromocytomas and paragangliomas -- Diagnosis and management of inheritable kidney cancer syndromes -- Diagnosis and management of inheritable pancreatic cancers/melanomas -- Diagnosis and management of inheritable basal cell skin cancer syndromes -- Diagnosis and management of inheritable adrenal cancers -- Diagnosis and management of inheritable thyroid cancers -- Diagnosis and management of inheritable meningiomas/acoustic neuroma -- Diagnosis and management of inheritable gastric cancer syndromes -- Diagnosis and management of inheritable carcinoid syndromes -- Diagnosis and management of inheritable sarcoma syndromes -- Genetic testing for rare cancer syndromes: the wider issues for patients, families and health professionals.
  • 2014 Springer
    Martin Dreyling, Michael E. Williams, editors.
    The past decade has witnessed tremendous progress in the diagnostic and therapeutic approaches to malignant lymphoma as well as in understanding of the underlying molecular pathogenesis. Optimal treatment strategies are now based not only on accurate diagnosis but also on thorough evaluation of clinical and molecular risk factors. Even more importantly, molecular targeted approaches have been shown to be effective in the treatment of distinct lymphoma subtypes. Against this background, clinical management of especially the rare lymphomas remains a challenge for the general oncologist. This book provides a comprehensive overview of current treatment strategies in these rare lymphoma subtypes. Experts in the field from around the world describe the histomorphology in a clinically relevant manner, consider the role of risk factors in detail, and discuss the spectrum of therapeutic approaches. Special emphasis is placed on the translation of molecular science into clinical care, and a disease-specific algorithm is proposed for each entity. This book will prove an excellent resource for both experienced and inexperienced practitioners.
  • 2015 Springer
    Franco Rongioletti, Irina Margaritescu, Bruce R. Smoller, editors ; with the contributors of Werner Kempf.
    This book provides practitioners with a single volume that reviews the clinical and pathologic features of rarely encountered cutaneous neoplasms. The text includes an in-depth discussion of the clinical findings, as well as the histologic and immunologic features of these diseases that are rarely encountered, reported, or recognized. Additional laboratory data used to make and support the diagnoses with some therapeutic and prognostic hints are discussed for each entity. The volume is organized into general categories correlating with the cell(s) of origin. An atlas of clinical manifestations is presented for each entity that will serve as a bedside clinical reference, followed by a series of photomicrographs depicting the histologic changes. In all cases, recent updates on molecular tools helpful in attaining the diagnosis are added to the sections on histology and immunohistochemistry. Rare Malignant Skin Tumors is a valuable bedside reference for the practicing dermatopathologist, general pathologist reviewing skin biopsies, general dermatologists, cutaneous oncologists and Mohs? surgeons.
  • 2015 Springer
    Antonio Lopez-Beltran, Carmen L. Menendez, Rodolfo Montironi, Liang Cheng.
  • 2012 Springer
    edited by Dominik T. Schneider, Ines B. Brecht, Thomas A. Olson, Andrea Ferrari.
    This is the first book to be devoted exclusively to rare tumors in children and adolescents, and its aim is to provide up-to-date information on their diagnosis and clinical management. The opening section of the book addresses general issues including epidemiology, risk factors/etiology, biology and genetics, prevention, early detection, and screening. It also discusses solutions to assist in the management of rare tumors, such as international networking and internet platforms, thus providing the reader with access to the developing clinical network for rare tumors in children. In the second section, specific malignancies are described, with practical guidance on diagnostic workup, multimodal therapy, survival outcome, follow-up, and adverse effects. These chapters are organized by site according to the clinician{u2019}s approach to the patient. Each chapter includes an introduction to the differential diagnostic assessment of tumors at the site in question, encompassing both frequent and rare tumor types. This approach should enable the clinician to take rare entities into account during the diagnostic assessment, so that the initial diagnostic steps are performed optimally. Each chapter goes on to provide detailed therapeutic guidelines for specific rare tumors. The authors are a multidisciplinary group of specialists who have dedicated themselves to this group of tumors. This well-illustrated book will prove an invaluable source of information for all pediatricians and oncologists faced with the often difficult task of diagnosing and treating rare tumors in the pediatric age group.
  • 2006 Springer
    edited by Channing Der.
  • 2014 Springer Protocols
    edited by Lorenza Trabalzini, Saverio Francesco Retta.
    The Ras superfamily of small GTPases : the unlocked secrets / Luca Goitre [and three others] -- A novel method for the production of fully modified K-Ras 4B / Tanmay S. Chavan [and four others] -- Metabolic labeling of Ras with tritiated palmitate to monitor palmitoylation and depalmitoylation / Frederick D. Tsai [and three others] -- Ubiquitination of Rac1 by inhibitors of apoptosis (IAPs) / Tripat Kaur Oberoi-Khanuja and Krishnaraj Rajalingam -- Ras GTPases are both regulators and effectors of redox agents / Elisa Ferro [and four others] -- Biophysical and proteomic characterization strategies for cysteine modifications in Ras GTPases / G. Aaron Hobbs, Harsha P. Gunawardena, and Sharon L. Campbell -- Use of the yeast two-hybrid technology to isolate molecular interactions of Ras GTPases / Elisa Ferro, Eva Baldini, and Lorenza Trabalzini -- Screening for MAPK modulators using an In-Cell Western assay / Simon Schnaiter [and seven others] -- Behavioral methods for the study of the Ras-ERK pathway in memory formation and consolidation : passive avoidance and novel object recognition tests / Raffaele d'Isa, Riccardo Brambilla, and Stefania Fasano -- Functional phosphoproteomics of oncogenic KRAS signaling / Putty-Reddy Sudhir and Jeou-Yuan Chen -- Pull-down assay for analysis of integrin-mediated activation of Rap proteins in adherent platelets / Gianni Francesco Guidetti and Mauro Torti -- Combined pulldown and time-lapse microscopy studies for determining the role of Rap1 in the crosstalk between integrins and cadherins / Luca Goitre and Saverio Francesco Retta -- Fluorescence microscopy study of Rap1 subcellular localization / Luca Goitre, Valentina Cutano, and Saverio Francesco Retta -- An in vitro system to evaluate the scaffold function of the RalA effector protein RalBP1 / David F. Kashatus -- Analysis of the Rit subfamily GTPase-mediated signaling and neuronal differentiation and survival / Geng-Xian Shi and Catherine N. Kaminski -- Immunofluorescence methods in studies of the GTPase Ran and its effectors in interphase and in mitotic cells / Giulia Guarguaglini, Valeria de Turris, and Patrizia Lavia -- High-resolution scanning electron microscopy for the imaging of nuclear pore complexes and Ran-mediated transport / Lihi Shaulov, Boris Fichtman, and Amnon Harel -- Effector recruitment method to study spatially regulated activation of Ras and Rho GTPases / Lauren P. Huff, Molly J. DeCristo, and Adrienne D. Cox -- Real-time visualization and quantification of native Ras activation in single living cells / Christoph Biskup and Ignacio Rubio -- Nanoclustering and heterogeneous membrane diffusion of Ras studied by FRAP and RICS analysis / Camilo Guzmâan, Maja éSolman, and Daniel Abankwa -- Analyzing the roles of Rho GTPases in cancer cell migration with a live cell imaging 3D-morphology-based assay / Audrey Colomba and Anne J. Ridley -- Analysis of Rho GTPase-induced localization of nanoscale adhesions using fluorescence nanoscopy / Annica K.B. Gad [and three others] -- Yeast as a model for Ras signalling / Renata Tisi, Fiorella Belotti, and Enzo Martegani -- Methods to study the Ras2 protein activation state and the subcellular localization of Ras-GTP in Saccharomyces cerevisiae / Sonia Colombo and Enzo Martegani -- Ras proteins signaling in the early metazoan Dictyostelium discoideum / Enrico Bracco and Barbara Pergolizzi.
  • 2009
    George Paxinos, Charles Watson.
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer
    Angela Heiser ; foreword by John H.K. Liu.
  • 2010
    Douglas Scott Jones, II.
    Ligand-receptor interactions govern nearly all cellular processes, and dysregulation leads to a range of diseases including cancer, autoimmune diseases, and regenerative disorders. As such, new strategies to target ligand-receptor interactions for therapeutic applications are an important area of research. To develop enhanced agonists and antagonists of the Met receptor, a critical target in cancer therapy and regenerative medicine, we engineered a fragment of the natural activating ligand (termed NK1). First, NK1 was evolved for improved stability using directed evolution. Then, using the activation mechanism of Met by NK1, the resulting enhanced stability mutants were rationally engineered for either agonistic or antagonistic activity. Next, the rationally engineered mutants were used as 'molecular tools' to provide further insights into NK1 structure and function. Finally, these insights supported additional rational engineering to generate further enhanced agonistic proteins. The antagonistic and agonistic proteins developed in this thesis hold promise as cancer therapeutics and diagnostics or for regenerative medicine applications, respectively. This work also supports native ligands as a promising starting point for development of therapeutic proteins.
  • 2015 CRCnetBASE
    edited by Giuseppe Micieli, Diana Amantea.
    Section 1. Update on the clinical management of stroke patients -- section 2. Clinical needs : diagnosis and brain imaging -- section 3. Lessons from the clinical setting to improve translational approaches -- section 4. Promising therapeutic strategies for acute stroke treatment -- section 5. Novel approaches to promote recovery.
  • 2016 ScienceDirect
    edited by Chalia Vijaya Kumar.
  • 2012 Springer Protocols
    edited by Yi Zheng.
    On setting up and assessing docking simulations for virtual screening / Jacek Biesiada, Aleksey Porollo, and Jaroslaw Meller -- Virtual ligand screening combined with NMR to identify Dvl PDZ domain inhibitors targeting the Wnt signaling / Jufang Shan and Jie J. Zheng -- Rational design of Rho GTPase-targeting inhibitors / Xun Shang and Yi Zheng -- Rational design of peptide ligands against a glycolipid by NMR studies / Wenyong Tong [and others] -- Combinatorial strategy for the acquisition of potent and specific protein tyrosine phosphatase inhibitors / Sheng Zhang [and others] -- Identification of allosteric inhibitors of p21-activated kinase / Julien Viaud and Jeffrey R. Peterson -- Using a modified yeast two-hybrid system to screen for chemical GEF inhibitors / Anne Blangy and Philippe Fort -- Random mutagenesis of peptide aptamers as an optimization strategy for inhibitor screening / Nathalie Bouquier [and others] -- Screening strategy for trapping the inactive conformer of a dimeric enzyme with a small molecule inhibitor / Charles S. Craik and Tina Shahian -- Use of a fluorescent ATP analog to probe the allosteric conformational change in the active site of the protein kinase PDK1 / Valerie Hindie, Laura A. Lopez-Garcia, and Ricardo M. Biondi -- Affinity purification of protein kinases that adopt a specific inactive conformation / Pratistha Ranjitkar and Dustin J. Maly -- Determination of the kinetics and thermodynamics of ligand binding to a specific inactive conformation in protein kinases / Sanjay B. Hari, Pratistha Ranjitkar, and Dustin J. Maly -- Purification and specific assays for measuring APE-1 endonuclease activity / Adrian Esqueda [and others] -- In vitro screening to identify drug-resistant mutations for target-directed chemotherapeutic agents / Mohammad Azam -- Utilizing antagomiR (antisense microRNA) to knock down microRNA in murine bone marrow cells / Chinavenmeni S. Velu and H. Leighton Grimes -- Synthesis, conjugation, and labeling of multifunctional pRNA nanoparticles for specific delivery of siRNA, drugs, and other therapeutics to target cells / Peixuan Guo [and others] -- Mouse models for tumor metastasis / Shengyu Yang, J. Jillian Zhang, and Xin-Yun Huang.
  • 2009
    Michael Nathaniel Cantor.
    Status: Not Checked OutLane Catalog Record
  • 2002 Karger
    volume editors, D. Felix, E. Oestreicher.
    Machine generated contents note: 1 Anatomical Differences in the Peripheral Auditory System of Mammals and Man -- Felix, H. (Zfirich) -- 11 Neurotransmission in the Human Labyrinth -- Schrott-Fischer, A.; Kammen-Jolly, K.; Scholtz, A.W. (Innsbruck); -- Kong, W.-J. (Hua-Zhong); Eybalin, M. (Montpellier) -- 18 Different Action of Memantine and Caroverine on Glutamatergic Transmission in the Mammalian Cochlea -- Oestreicher, E. (Munich/Berne); Ehrenberger, K. (Vienna); Felix, D. (Berne) -- 26 Role of Substance P in the PeripheralVestibular and Auditory System -- Felix, H. (Zirich); Oestreicher, E. (Munich/Berne); Felix, D. (Berne); -- Ehrenberger, K. (Vienna) -- Hair Cells - Ion Channels -- 35 Calcium Channels in Mouse Hair Cells: Function, Properties and Pharmacology -- Engel, J.; Michna, M. (Tiibingen); Platzer, J.; Striessnig, J. (Innsbruck) -- 42 Adrenergic and Muscarinic Control of Cochlear Endolymph Production -- Wangemann, P. (Manhattan) -- 51 Cochlear Blood Flow Regulation -- Wangemann, P. (Manhattan) -- 58 ETA Receptors in the Gerbil Spiral Modiolar Artery -- Scherer, E.Q.; Wangemann, P. (Manhattan) -- Immunology - Cell Cycle -- 66 Immunological Damage to the Inner Ear: Current and Future Therapeutic Strategies -- Ryan, A.F. (San Diego/La Jolla); Pak, K.; Low, W; Battaglia, A.; Mullen, L.; -- Harris, J.P.; Keithley, E.M. (San Diego) -- 75 Pharmacological Influence on Inner Ear Endothelial Cells in Relation to the Pathogenesis of Sensorineural Hearing Loss -- Gloddek, B.; Lamm, K.; Arnold, W. (Munich) -- 84 Mpv17 Mouse Strain -A Model for the Relationship between the Kidney and the Inner Ear -- Meyer zum Gottesberge, A.M.; Balz, V. (Diisseldorf); Felix, H. (Zurich) -- Ototoxicity, Noise and Aging -- 91 Sensitivity to Glutamate Neurotoxicity in Different Developmental Periods of the Rat Cochlea -- Carricondo, F; Bartolome, M.V; Vicente-Torres, M.A.; Fernmndez-Pacheco, P.; -- Rodriguez, T.; Gil-Loyzaga, P. (Madrid) -- 96 Protective Mechanisms of Sound Conditioning -- Niu, X.; Canlon, B. (Stockholm) -- 106 Effects of Aging on C57BL/6J Mice: An Electrophysiological and Morphological Study -- Bartolom6, M.V; del Castillo, E.; L6pez, L.M.; Carricondo, F.; Poch-Broto, J.; -- Gil-Loyzaga, P. (Madrid) -- 112 Effects of Aging on Cochlear MonoamineTurnover -- Vicente-Torres, M.A.; Davila, D.; Mufioz, E.; Gil-Loyzaga, P. (Madrid) -- 116 Degeneration Pattern of Human First-Order Cochlear Neurons -- Felix, H.; Pollak, A. (Zfirich); Gleeson, M. (London); Johnsson, L.-G. (Helsinki) -- 124 The Inner Hair Cell Afferent/Efferent Synapses Revisited: A Basis for New Therapeutic Strategies -- Puel, J.-L.; Ruel, J.; Guitton, M.; Pujol, R. (Montpellier) -- 131 Neurotransmission of the Cochlear Inner Hair Cell Synapse - Implications for Inner Ear Therapy -- Oestreicher, E. (Munich/Berne); Arnold, W. (Munich); Felix, D. (Berne) -- 140 Simulation of Methods for Drug Delivery to the Cochlear Fluids -- Salt, A.N. (St. Louis) -- 149 Transtympanic Endoscopy for Drug Delivery to the Inner Ear Using a New Microendoscope -- Plontke, S.K.-R. (Tuibingen); Plinkert, PK.; Plinkert, B. (Tiibingen/Homburg, Saar); -- Koitschev, A.; Zenner, H.-P.; L6wenheim, H. (Tiibingen) -- 156 Clinical Experience with Caroverine in Inner Ear Diseases -- Ehrenberger, K. (Vienna).
    Also available: Print – 2002
  • 2005 Springer
    Joseph Schatzker, Marvin Tile ; with contributions by T.S. Axelrod, R. Hu, and D.J.G. Stephen.
    Also available: Print – 2005
  • v. 2-6, 1922-23.
    von Fr. Kopsch.
    Status: Not Checked OutLane Catalog Record
    Abt. 2. Knochen, Bänder -- Abt. 3. Muskeln, Gefässe -- Abt. 4. Eingeweide -- Abt. 5/6. Nervensystem, Sinnesorgane : nebst Anhang, Grundzüge der Oberflächen- und Projektions-Anatomie.
  • 2009 ebrary
    Robert Laureno.
    This book is a contribution to the history of neurology and the history of American medicine. Adams, one of the greats of neurology, advanced the fields of neurology, neuropathology, internal medicine, psychiatry, pediatrics, and psychology. Drawing on 50 interviews with Raymond D. Adams and on interviews with 50 other professionals and family members, this book documents his contributions to knowledge, his expansion of the realm of neurology, and his vast impact as an educator and author. Following an introductory chapter, "The Phenomenon of Raymond Adams," the book deals chronologically with the phases of his life, education, and professional work. Another section of the book is arranged by disease categories and related topics, explaining his investigative work and ideas. There is a chapter of summation, analyzing the accomplishment and legacy of Dr. Adams. Numerous appendices include letters of correspondence, a letter of nomination, and extracts of interviews with other neurologists. These documents provide further insight into Adam's personality and work patterns.
  • 2015 Springer
    Fredrick M. Wigley, Ariane L. Herrick, Nicholas A. Flavahan, editors.
  • 2010 Springer
    Kurt Hellmann, Walter Rhomberg, editors.
    "Razoxane and dexrazoxane are two novel drugs with some uniquely useful features. They block cell division at the G2/M border, but nowhere else, so that they have a low toxicity profile. They suppress tumor metastasis and haemorrhages through normalization of pathological blood vessels. Razoxane potentiates radiotherapy especially in the treatment of soft tissue sarcomas and gastrointestinal neoplasms. They protect normal tissues against toxic chemicals, e.g. the myocardium against anthracyclines or subcutaneous tissue against injuries caused by incidental extravasations of anthracyclines. Dexrazoxane is the only drug approved by the FDA/EMEA for the specific purpose of preventing cardiac damage when giving the widely used and effective antitumor anthracyclines. The reduction of cardiotoxicity is achieved without response reduction or reducing of time to progression of tumors. While the full analysis of their actions at the molecular level is not yet completely understood, it seems most likely that it is via an inhibition on the topoisomerase II a. Moreover, the drugs have the ability to chelate several metals including iron, copper or zinc. The protection of normal tissues is nowhere more important than that of brain, and there are indications that the proteins thought to be responsible for the ravages of Alzheimer's disease could be stabilized by one or both these drugs."--P. [4] of cover.
  • 2006 Springer
    [edited by] Maurizio Fanciulli.
    Rb as a positive transcriptional regulator during epithelial differentiation / Chantal E. Crémisi and Linda L. Pritchard -- pRb in the differentiation of normal and neoplastic cells / Deborah Pajalunga, Grazia Camarda and Marco Crescenzi -- Regulation of DNA replication by the retinoblastoma tumor suppressor protein / Erik S. Knudsen and Steven P. Angus -- New insights into transcriptional regulation by Rb : one size no longer fits all / Peggy J. Farnham -- Regulation of Rb function by noncyclin dependent kinases / Jaya Padmanabhan and Srikumar P. Chellappan -- Diverse regulatory functions of the E2F family of transcription factors / Fred Dick and Nicholas Dyson -- Regulation of E2F-responsive genes through histone modifications / Estelle Nicolas, Laetitia Daury and Didier Trouche -- Emerging roles for the retinoblastoma gene family / Jacqueline L. Vanderluit, Kerry L. Ferguson and Ruth S. Slack -- Rb and cellular differentiation / Lucia Latella and Pier Lorenzo Puri.
  • pt. A-C, 1982.
    edited by Harris Busch and Lawrence Rothblum.
    Status: Not Checked OutLane Catalog Record
  • Status: Not Checked OutLane Catalog Record
  • 2014
    Dr. Allan H. Ropper and Brian David Burrell.
    Status: Not Checked OutLane Catalog Record
    "Tell the doctor where it hurts." It sounds simple enough, unless the problem affects the very organ that produces awareness and generates speech. What is it like to try to heal the body when the mind is under attack? In this book, Dr. Allan Ropper and Brian Burrell take the reader behind the scenes at Harvard Medical School's neurology unit to show how a seasoned diagnostician faces down bizarre, life-altering afflictions. Like Alice in Wonderland, Dr. Ropper inhabits a world where absurdities abound: A figure skater whose body has become a ticking time-bomb. A salesman who drives around and around a traffic rotary, unable to get off. A college quarterback who can't stop calling the same play. A child molester who, after falling on the ice, is left with a brain that is very much dead inside a body that is very much alive. A mother of two young girls, diagnosed with ALS, who has to decide whether a life locked inside her own head is worth living. How does one begin to treat such cases, to counsel people whose lives may be changed forever? How does one train the next generation of clinicians to deal with the moral and medical aspects of brain disease? Dr. Ropper and his colleague answer these questions by taking the reader into a rarified world where lives and minds hang in the balance"-- Provided by publisher.
  • 2012 Springer
    Daniel F. Shreeve.
    Machine generated contents note: 1.Introduction -- Format of the Exercise -- What Is Attachment? -- The Place of Attachment in Nature -- The Process of Attachment in Early Childhood -- Definition of Reactive Attachment Disorder (RAD) -- Differential Diagnosis -- Comorbidity -- 2.Vignette of "Jorge" -- pt. 1 Jorge as a Toddler -- Case Point: International Adoption -- pt. 2 Jorge at Preschool Age -- Case Point: Neglect, Growth, and Medical Problems -- pt. 3 Jorge in Kindergarten -- Case Point: The Retrospective Evaluation of Child Abuse -- pt. 4 Jorge in First Grade -- Case Point: Alexythymia and Attachment -- pt. 5 Jorge in Second and Third Grades -- Case Point: Longitudinal Course and the Trait of Indiscriminate Friendliness -- pt. 6 Jorge in fourth and fourth Grades -- Test #1 Case-Related Questions -- 3.Theories for the Origin of RAD -- pt. 1 Biological Basis -- Genetic Coding of Attachment -- Epigenetic Models -- Biological Effect of Maternal Stress -- Maturation and Lesions of Early Limbic Pathways -- Stress Tolerance and the Developing Brain -- Physiological Measurement of Attachment Disorder -- pt. 2 Psychological Factors -- A Deficit Model -- The Application of Joint Attention to Attachment -- Avoidance and Detachment -- The Phenomenon of Shame -- The Impact of Trauma -- pt. 3 Social Origins -- Attachment and Social Impairment -- Theory of Mind and the False Belief Test -- Anticipatory Interactive Planning -- 4.A Discussion and Critique of RAD -- 5.Therapy for RAD -- Test #2 Theory Questions -- B.Matching Section.
  • 2015
    Matt McCarthy.
    Status: Not Checked OutLane Catalog Record
    "This funny, candid memoir about the author's intern year at a New York hospital provides a scorchingly frank look at how doctors are made, taking readers into the critical care unit to see one burgeoning physician's journey from ineptitude to competence. After his professional baseball career failed to launch, Matt McCarthy went to Harvard Medical School and on to a coveted residency slot in New York. But when he almost lost a patient on his first day after making what he believed to be a terrible error, he found himself facing the harsh reality of a new doctor's life--one in which even overachievers find themselves humbled, and in which med school training has little to offer in navigating the emotional rollercoaster of dealing with actual patients. Luckily for McCarthy, his second-year-resident adviser (whom he calls "Baio", owing to a resemblance to a Charles in Charge-era Scott Baio) was an offbeat genius, with a knack for breaking down the complicated process of treating patients. But neither doctor could offer much help to a patient named Barney, who had been living in the hospital while waiting for a new heart, and whom McCarthy slowly befriended over the course of the year in ways that changed his perception of what it means to be a physician. Mixing the tense drama of ER with the screwball humor of Scrubs, McCarthy offers a window on to hospital life that dispenses with sanctimony and self-seriousness while emphasizing the black-comic paradox of becoming a doctor: How do you learn how to save lives in a job where there is no practice? This "One L for doctors" will inspire and entertain physicians and patients alike"-- Provided by publisher.
  • 2011
    Andrew Bruce Holbrook.
    High Intensity Focused Ultrasound (HIFU) is a promising technique for non-invasively destroying tissue deep inside the body, without damage to the skin or intervening tissue. The technique has been performed under both ultrasound and magnetic resonance imaging (MRI) guidance in multiple organ systems, including the uterus, prostate, and brain. Treating unresectable cancers and metastases in the liver is another potential application for HIFU. However the method is currently limited to breath-hold treatments under general anesthesia. The purpose of this work is to build a system for a less-invasive free-breathing MRI-guided real time liver ablation. The three key elements to the system are 1) real-time temperature imaging suitable for the free breathing liver, 2) rapid focal spot localization, and 3) beam steering during free-breathing. For in vivo temperature imaging in the presence of motion, liver motion in 5 normal volunteers was studied. The maximum velocity of the liver was found to be 10.8 mm/s in the superior-inferior direction and 4.23 mm/sec in the anterior-posterior direction. A pulse sequence that allows for high speed, high resolution MR-thermometry utilizing the proton resonant frequency shift (PRF shift) thermometry technique with referenceless image reconstruction was developed. The sequence utilizes outer volume suppression and readout-segmented EPI trajectories to increase the frame rate while not sacrificing resolution. Ablations in a moving phantom moving at speeds of 13 mm/s are compared to static ablations and found to have good agreement. Additionally, SNR characteristics were measured in the liver of normal volunteers, where the average standard deviation was 1.48 degrees C. A HIFU focus must be visualized prior to performing the actual ablation. In static ablations, a non-lethal thermal test spot is performed to calibrate the focus. However, in the liver, perfusion and the need to steer the beam with the motion makes this technique difficult and still require significant energy. The use of MR acoustic radiation force imaging (MR-ARFI) was investigated as a method for visualizing the focus without the high power of a test spot but with the same location accuracy as the thermometry images. The MR-ARFI sequence is a single shot spin echo sequence with an identical readout trajectory to the thermometry sequence that can localize tissue focus displacement in two acquisitions. MR-ARFI displacement maps were compared to foci in ablation thermometry images in both phantoms and in porcine livers. MR-ARFI was found to be effective in focus targeting calibration, with a standard deviation error of only 1.13 mm between displacement and thermal foci in vivo. Using these two sequences and an MR-tracking sequence for HIFU transducer localization, a technique for steering a HIFU focus to a specific target was developed. A lookup table of transducer location, target location, and respiration value measured by an external respiratory belt is created prior to an ablation. The focus location is varified using the gated MR-ARFI pulse sequence discussed prior. During the ablation, the focus is steered based on the lookup table and the current respiration value. This method is investigated by performing steered HIFU ablations in moving phantom experiments and compared to non-steered moving ablations and static ablations. Utilizing this technique, steered HIFU ablations required 1039 J to reach a temperature of 15 degrees C, compared to 7480 J and 921 J for non-steered and static ablations, respectively.
  • 2008 ScienceDirect
    Robert M. Rydzewski.
    The drug discovery business to date -- The drug discovery business to come -- Industrial considerations -- how things get done : the project team -- Project considerations -- Hit generation -- Turning hits into drugs -- Initial properties -- ADME and PK properties -- Toxicity related properties -- A career in drug discovery research.
  • 2015
    authors: Stephen Zuckerman, Katie Merrell, Robert A. Berenson, Nicole Cafarella Lallemand, Jonathan Sunshine.
    The analyses included in this project show that there is not a simple or obvious solution that would realign Medicare payment incentives to promote primary care services. Although we initially considered several approaches to making changes within the RBRVS (e.g., altering global surgical periods or changing payments for component coding), the study of practice expense RVU methods seemed most promising to the technical panel.
  • 2014 Springer
    Francesco Fulvio Faletra...[et al.].
    This book describes the use of real-time three-dimensional transesophageal echocardiography (3D TEE) in percutaneous interventional procedures, underlining its growing role and acceptance among interventional cardiologists, while also considering technique-related weaknesses.
  • M. Tevfik Dorak (ed.).
    An introduction to real-time PCR / Gregory L. Shipley -- Data analysis and reporting / Pamela Scott Adams -- Relative quantification / Michael W. Pfaffl -- Normalization / Jim Huggett, Keertan Dheda and Stephen A. Bustin -- High-throughput primer and probe design / Xiaowei Wang and Brian Seed -- Quantitative analysis of ocular gene expression / Stuart N. Peirson -- Quantitative gene expression by real-time PCR / Thomas D. Schmittgen -- Real-time PCR using SYBR Green / Frederique Ponchel -- High-resolution melting analysis for scanning and genotyping / Virginie Dujols ... [et al.] -- Quantitative analyses of DNA methylation / Lin Zhou and James (Jianming) Tang -- Mitochondrial DNA analysis / Steve E. Durham and Patrick F. Chinnery -- Real-time immuno-PCR / Kristina Lind and Mikael Kubista -- Clinical microbiology / Burcu Cakilci and Mehmet Gunduz -- Clinical virology / David M. Whiley and Theo P. Sloots -- Solid organ transplant monitoring / Omaima M. Sabek -- Real-time PCR applications in hematology / Anne M. Sproul -- Real-time PCR for prenatal diagnosis of monogenic diseases caused by single nucleotide changes / Joanne Traeger-Synodinos, Christina Vrettou and Emmanuel Kanavakis.
  • 2012 Springer
    Annette Vegas, Massimiliano Meineri, Angela Jerath.
    Technology and 3D Imaging -- 3D TEE Basic Views -- Native Cardiac Valves -- Cardiac Prosthetic Valves -- Left and Right Ventricles 3D Imaging -- Cardiomyopathy Ventricles 3D Imaging -- Aorta -- Cardiac Masses 3D Imaging -- Congenital Heart 3D Imaging -- Miscellaneous 3D Imaging.
  • 2006 ebrary
    2006 NAP
    Stephen A. Merrill and Anne-Marie Mazza, editors.
    The patenting and licensing of human genetic material and proteins represents an extension of intellectual property (IP) rights to naturally occurring biological material and scientific information, much of it well upstream of drugs and other disease therapies. This report concludes that IP restrictions rarely impose significant burdens on biomedical research, but there are reasons to be apprehensive about their future impact on scientific advances in this area. The report recommends 13 actions that policy-makers, courts, universities, and health and patent officials should take to prevent the increasingly complex web of IP protections from getting in the way of potential breakthroughs in genomic and proteomic research. It endorses the National Institutes of Health guidelines for technology licensing, data sharing, and research material exchanges and says that oversight of compliance should be strengthened. It recommends enactment of a statutory exception from infringement liability for research on a patented invention and raising the bar somewhat to qualify for a patent on upstream research discoveries in biotechnology. With respect to genetic diagnostic tests to detect patient mutations associated with certain diseases, the report urges patent holders to allow others to perform the tests for purposes of verifying the results.
  • 2011 Springer
    Giuseppe Mancia, Stéphane Laurent, European Society of Hypertension Task Force Members.
    Introduction -- Assessment of subclinical organ damage for stratification of total cardiovascular risk -- Treatment approach -- Treatment strategies -- Therapeutic approach in special conditions -- Treatment of associated risk factors -- New trials needed.
  • 2005 Springer
    E. Marani, J.H.R. Schoen.
  • 2015 Springer
    Louise Cummings.
    This book argues that in order to be truly effective, public health must embrace a group of reasoning strategies that have traditionally been characterized as informal fallacies. It will be demonstrated that these strategies can facilitate judgements about complex public health issues in contexts of uncertainty. The book explains how scientists and lay people routinely resort to the use of these strategies during consideration of public health problems. Although these strategies are not deductively valid, they are nevertheless rationally warranted procedures. Public health professionals must have a sound understanding of these cognitive strategies in order to engage the public and achieve their public health goals. The book draws upon public health issues as wide ranging as infectious diseases, food safety and the potential impact on human health of new technologies. It examines reasoning in the context of these issues within a large-scale, questionnaire-based survey of nearly 900 members of the public in the UK. In addition, several philosophical themes run throughout the book, including the nature of uncertainty, scientific knowledge and inquiry. The complexity of many public health problems demands an approach to reasoning that cannot be accommodated satisfactorily within a general thinking skills framework. This book shows that by developing an awareness of these reasoning strategies, scientists and members of the public can have a more productive engagement with public health problems.
  • 2008 HighWire
    International Commission on Radiation Units and Measurements.
  • 2012 ScienceDirect
    [edited by] Xin-Yuan Liu, Sidney Pestka, Yu-Fang Shi.
    Cancer continues to be one of the major causes of death throughout the developed world, which has led to increased research on effective treatments. Because of this, in the past decade, rapid progress in the field of cancer treatment has been seen. Recent Advances in Cancer Research and Therapy reviews in specific details some of the most effective and promising treatments developed in research centers worldwide. While referencing advances in traditional therapies and treatments such as chemotherapy, this book also highlights advances in biotherapy including research using Interferon and Super.
  • 2011 ScienceDirect
    edited by Zbigniew Darzynkiewicz ... [et al.].
    Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. This new edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay. Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays * Discusses many new assays developed since the previous edition. Presents recent developments in cytometric intrumentation/technology.
  • 2011 ScienceDirect
    edited by Zbigniew Darzynkiewicz ... [et al.].
    Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. This new edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay. Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays. Discusses many new assays developed since the previous edition * Presents recent developments in cytometric intrumentation/technology.
  • 2013 Karger
    editors, Matthew W. Gillman, Peter D. Gluckman, Ron G. Rosenfeld.
  • 2008 Springer
    edited by Jean-Pierre Bocquet-Appel.
    Introduction / Jean-Pierre Bocquet-Appel -- From genes to numbers : effective population sizes in human origins / John Hawks -- Assessment of land surveys in Greece : contributions and limitations / Jean-Nicolas Corvisier -- Estimation of an age distribution with its confidence intervals using an iterative Bayesian procedure and a bootstrap sampling approach / Jean-Pierre Bocquet-Appel and Jean-Noël Bacro -- Model life tables for pre-industrial populations : first application in palaeodemography / Isabelle Séguy ... [et al.] -- The Halley band for paleodemographic mortality analysis / Marc A. Luy and Ursula Wittwer-Backofen -- Modeling Paleolithic predator-prey dynamics and the effects of hunting pressure on prey "choice" / Mary C. Stiner ... [et al.] -- The demography of prehistoric fishing/hunting people : a case study of the Upper Columbia area / Nathan B. Goodale, Ian Kuijt, Anna M. Prentiss -- The paleodemography of central Portugal and the Mesolithic-Neolithic transition / Mary Jackes and Christopher Meiklejohn -- The Libben Site : a hunting, fishing, and gathering village from the Eastern Late Woodlands of North America : analysis and implications for palaeodemography and human origins / Richard S. Meindl, Robert P. Mensforth, C. Owen Lovejoy.
  • 2010 ScienceDirect
    edited by Anders Björklund, M. Angela Cenci.
    Section I. Genetic and molecular mechanisms of neurodegeneration in PD -- Chapter 1. Identifying PD-causing genes and genetic susceptibility factors: Current approaches and future prospects / Thomas Gasser -- Chapter 2. The impact of genetic research on our understanding of Parkinson's disease / Ian Martin, Valina L. Dawson, Ted M. Dawson -- Chapter 3. Unravelling the role of defective genes / Mark R. Cookson -- Chapter 4. What causes the death of dopaminergic neurons in Parkinson's disease? / D. James Surmeier, Jaime N. Guzman, Javier Sanchez-Padilla, Joshua A. Goldberg -- Chapter 5. Intracellular signalling pathways in dopamine cell death and axonal degeneration / Robert E. Burke -- Chapter 6. Control of mitochondrial integrity in Parkinson's disease / Cristofol Vives-Bauza, Maja Tocilescu, Rosa L.A. deVries, Dana M. Alessi, Vernice Jackson-Lewis, Serge Przedborski -- Chapter 7. Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: Implications for Parkinson's disease pathogenesis and therapies / Abid Oueslati, Margot Fournier, Hilal A. Lashuel -- Section II. Cellular and system-level pathophysiology of the basal ganglia in PD -- Chapter 8. The role of dopamine in modulating the structure and function of striatal circuits / D. James Surmeier, Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian, Joshua L. Plotkin -- Chapter 9. Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson's disease / Fabrizio Gardoni, Veronica Ghiglieri, Monica di Luca, Paolo Calabresi -- Chapter 10. Pathophysiological roles for purines: Adenosine, caffeine and urate / Micaela Morelli, Anna R. Carta, Anil Kachroo, Michael A. Schwarzschild -- Chapter 11. Maladaptive striatal plasticity in l-DOPA-induced dyskinesia / M. Angela Cenci, Christine Konradi -- Chapter 12. Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease / Christelle Baunez, Paolo Gubellini -- Chapter 13. Computational physiology of the basal ganglia in Parkinson's disease / Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer, Hagai Bergman -- Chapter 14. Neurocomputational models of motor and cognitive deficits in Parkinson's disease / Thomas V. Wiecki, Michael J. Frank.
  • 2010 ScienceDirect
    edited by Anders Björklund, M. Angela Cenci.
    Section I. Animal models of PD -- Chapter 1. What have we learned from Drosophila models of Parkinson's disease? / Ming Guo -- Chapter 2. Neurotoxic in vivo models of Parkinson's disease: recent advances / Jason R. Cannon, J. Timothy Greenamyre -- Chapter 3. Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease / Stephen B. Dunnett, Mariah Lelos -- Chapter 4. Genetic mouse models of Parkinson's disease: The state of the art / Iddo Magen, Marie-Françoise Chesselet -- Chapter 5. Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease / Ayse Ulusoy, Mickael Decressac, Deniz Kirik, Anders Björklund -- Chapter 6. Modeling neuroinflammatory pathogenesis of Parkinson's disease / Christopher J. Barnum, Malú G. Tansey -- Chapter 7. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future / Susan H. Fox, Jonathan M. Brotchie -- Section II. Exploring PD with brain imaging. -- Chapter 8. Abnormal metabolic brain networks in Parkinson's disease: from blackboard to bedside / Chris C. Tang, David Eidelberg -- Chapter 9. Imaging the nigrostriatal system to monitor disease progression and treatment-induced complications / Renju Kuriakose, A. Jon Stoessl -- Chapter 10. Brain imaging after neural transplantation / Marios Politis, Paola Piccini -- Chapter 11. Imaging non-motor aspects of Parkinson's disease / David J. Brooks, Nicola Pavese -- Section III. Frontiers in PD treatment -- Chapter 12. Gene therapy for dopamine replacement / Tomas Björklund, Erik Ahlm Cederfjäll, Deniz Kirik -- Chapter 13. Neurotrophic factor therapy for Parkinson's disease / Suresh Babu Rangasamy, Katherine Soderstrom, Roy A.E. Bakay, Jeffrey H. Kordower -- Chapter 14. Neural grafting in Parkinson's disease: Problems and possibilities / Patrik Brundin, Roger A. Barker, Malin Parmar -- CHAPTER 15. Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia / Emma L. Lane, Anders Björklund, Stephen B. Dunnett, Christian Winkler -- Chapter 16. Deep brain stimulation: state of the art and novel stimulation targets / Francisco A. Ponce, Andres M. Lozano -- Chapter 17. The challenge of non-motor symptoms in Parkinson's disease / K. Ray Chaudhuri, Per Odin.
  • 2010 Springer
    edited by Patrick C. Hallenbeck.
    Also available: Print – 2010
  • 2014 CRCnetBASE
    edited by Subramanyam Vemulpad and Joanne Jamie.
    Part 1. Relevance of traditional knowledge to biological testing -- part 2. Targeting important diseases using natural products (TK or non-TK based) -- part 3. Molecular biology, genomics, and proteomics : plant centered and person centered -- part 4. Personalized or person-centered medicine.
  • 2015 Springer
    edited by Maria Diakonova, PhD.
    Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
    Also available: Print – 2015
  • 2008 Springer
    Robert E. Anderson, Matthew M. LaVail and Joe G. Hollyfield, editors.
    Also available: Print – 2008
  • 2015 Springer
    Jasmine H. Francis, David H. Abramson, editors.
  • 2008 HighWire
    edited by Francisco Fernández-Avilés.
  • 2011 Karger
    volume editor, Yasuaki Harabuchi ; co-editors, Tatsuya Hayashi, Akihiro Katada.
    Since 1987, the most recent issues on tonsils and mucosal immunity have been discussed regularly at the 'International Symposiums on Tonsils and Mucosal Barriers of the Upper Airways' (ISTMB). This book is a summary of the topics presented during the 7th ISTMB covering both basic and clinical research on tonsils and upper airways. Presented are issues such as immunology and mucosal defense systems, bacteriology and virology, mucosal vaccine for upper airway infections, MALT, NALT and LALT, clinical manifests and pathogenesis of tonsil-related diseases such as IgA nephropathy, palmoplantal pustulosis, reactive arthritis diseases, and more related disorders. Further contributions reflect the association of tonsils with otitis media, allergic diseases in the upper airways, obstructive sleep apnea syndrome, and medical and surgical treatments for tonsil diseases. Otolaryngologists, pediatricians and immunologists who seek to unravel the mystery of the tonsil will find this volume of great assistance on their way to accomplish this task.
  • 2009 Springer
    Samantha J. Richardson, Vivian Cody [editors].
  • 2012 Springer
    Eleftherios Mylonakis, Frederick M. Ausubel, Michael Gilmore, Arturo Casadevall, editors.
    Amoeba provide insight into the origin of virulence in pathogenic fungi / Arturo Casadevall -- Of model hosts and man: using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as model hosts for infectious disease research / Justin Glavis-Bloom, Maged Muhammed, and Eleftherios Mylonakis -- Caenorhabditis elegans as an alternative model to study senescence of host defense and the prevention by immunonutrition / Tomomi Komura ... [et al.] -- Bacterial effectors: learning on the fly / Laurent Boyer ... [et al.] -- Drosophilia asthma model: what the fly tells us about inflammatory diseases of the lung / Thomas Roeder ... [et al.] -- Elucidating the in vivo targets of Photorhabdus toxins in real-time using Drosophilia embryos / Isabella Vlisidou, Nicholas Waterfield, and Will Wood -- Ecological niche modeling as a tool for understanding distributions and interactions of vectors, hosts, and etiologic agents of Chagas disease / Jane Costa and A. Townsend Peterson -- Where simplicity meets complexity: Hydra, a model for host-microbe interactions / René Augustin ... [et al.] -- Tick as a model for the study of primitive complement system / Petr Kopacek, Ondrej Hajdusek, and Veronika Buresova -- Model hosts for the study of oral candidiasis / Juliana Campos Junqueira -- Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock / Yongqing Li and Hasan B. Alam.
    Also available: Print – 2012
  • 2014 Springer
    Jagdish N. Sharma, editor.
    Basic and clinical aspects of bradykinin receptor antagonists -- The kallikrein-kinin pathways in hypertension and diabetes -- Tissue Kallikrein-kinin therapy in hypertension and organ damage -- Renal (tissue) kallikrein-kinin system in the kidney and novel potential drugs for salt-sensitive hypertension -- The Kallikrein-kinin system in diabetic retinopathy -- Genetic manipulation and genetic variation of the Kallikrein Kinin System; impact on cardiovascular and renal diseases.
  • 2005 Wellcome Trust
    edited by L.A. Christie and E.M. Tansey.
  • 2014 Wellcome Trust
    edited by C. Overy and E.M. Tansey.
  • 2012 Springer Protocols
    edited by Anthony P. Davenport.
    Receptor databases and computational websites for ligand binding / Brinda K. Rana, Philip E. Bourne, and Paul A. Insel -- How to use the IUPHAR receptor database to navigate pharmacological data / Chidochangu P. Mpamhanga [and others] -- Radioligand binding assays and their analysis / Janet J. Maguire, Rhoda E. Kuc, and Anthony P. Davenport -- Use of scintillation proximity assay to measure radioligand binding to immobilized receptors without separation of bound from free ligand / Jenny Berry, Molly Price-Jones, and Barbara Killian -- Visualization and analysis of vascular receptors using confocal laser scanning microscopy and fluorescent ligands / Craig J. Daly, Ingela Parmryd, and John C. McGrath -- Dissecting the pharmacology of G protein-coupled receptor signaling complexes using bimolecular fluorescence complementation / Laura E. Kilpatrick and Nicholas D. Holliday -- Live cell imaging of G protein-coupled receptors / Anke Teichmann [and others] -- Characterization of G-protein coupled receptor modulators using homogeneous cAMP assays / Daniel L. Bassoni [and others] -- Measurements of [beta]-arrestin recruitment to activated seven transmembrane receptors using enzyme complementation / Daniel L. Bassoni [and others] -- Quantitative phosphor imaging autoradiography of radioligands for positron emission tomography / Peter Johnstrom, Joseph L. Bird, and Anthony P. Davenport -- Dynamic in vivo imaging of receptors in small animals using positron emission tomography / Peter Johnstrom [and others] -- Cellular localization of receptors using antibodies visualized by light and dual labeling confocal microscopy / Anthony P. Davenport and Rhoda E. Kuc -- Detection of mRNA encoding receptors by in situ and northern hybridization / Alessandra P. Princivalle [and others].
  • 2011 Springer Protocols
    edited by Gary B. Willars and R.A. John Challiss.
    Inducible expression of G protein-coupled receptors in transfected cells / Beryl Koener and Emmanuel Hermans -- Using the Flp-In T-Rex system to regulate GPCR expression / Richard J. Ward, Elisa Alvarez-Curto, and Graeme Milligan -- Viral infection for GPCR expression in eukaryotic cells / Antonio Porcellini, Luisa Iacovelli, and Antonio De Blasi -- Generation of epitope-tagged GPCRs / Yan Huang and Gary B. Willars -- Use of site-directed mutagenesis to study GPCRs / Alex C. Conner [and others] -- Approaches to study GPCR regulation in native systems / Jonathon M. Willets -- Heterologous expression of GPCRs in fission yeast / John Davey and Graham Ladds -- Radioligand binding methods for membrane preparations and intact cells / David B. Bylund and Myron L. Toews -- Quantification of GPCR mRNA using real-time RT-PCR / Trond Brattelid and Finn Olav Levy -- Determining allosteric modulator mechanism of action : integration of radioligand binding and functional assay data / Christopher J. Langmead -- Design and use of fluorescent ligands to study ligand-receptor interactions in single living cells / Stephen J. Briddon, Barrie Kellam, and Stephen J. Hill -- Examining site-specific GPCR phosphorylation / Adrian J. Butcher, Andrew B. Tobin, and Kok Choi Kong -- Ubiquitination of GPCRs / Adriana Caballero and Adriano Marchese -- [35S]GTPgS binding as an index of total G-protein and Ga-subtype-specific activation by GPCRs / Rajendra Mistry, Mark R. Dowling, and R.A. John Challiss -- Using calcium imaging as a readout of GPCR activation / Martin D. Bootman and H. Llewelyn Roderick -- Measuring spatiotemporal dynamics of cyclic AMP signaling in real-time using FRET-based biosensors / Frank Gesellchen [and others] -- Determining the activation of Rho as an index of receptor coupling to G12/13 proteins / Michio Nakaya [and others] -- Use of translocating fluorescent biosensors for real-time monitoring of GPCR-mediated signaling events / Carl P. Nelson and R.A. John Challiss -- Study of GPCR-protein interactions using gel overlay assays and glutathione-S-transferase-fusion protein pull-downs / Ashley E. Brady [and others] -- Study of GPCR-protein interactions by BRET / Martina Kocan and Kevin D.G. Pfleger -- Time resolved FRET strategy with fluorescent ligands to analyze receptor interactions in native tissues : application to GPCR oligomerization / Martin Cottet [and others] -- Peptide affinity purification for the isolation and identification of GPCR-associated protein complexes / Pascal Maurice, Avais M. Daulat, and Ralf Jockers -- Tandem affinity purification and identification of GPCR-associated protein complexes / Avais M. Daulat, Pascal Maurice, and Ralf Jockers -- Identification of GPCR localization in detergent resistant membranes / Ranju Kumari and Anna Francesconi -- Analysis of GPCR localization and trafficking / James N. Hislop and Mark von Zastrow -- Statistical methods in research / Domenico Spina.
  • 2015 Springer Protocols
    edited by Serena Germano.
    Analysis of receptor tyrosine kinase (RTK) phosphorylation by immunoblotting / Martina McDermott and Norma O'Donovan -- Analysis of changes in phosphorylation of receptor tyrosine kinases : antibody arrays / Sweta Rani and Lorraine O'Driscoll -- Analysis of epidermal growth factor receptor dimerization by BS³ cross-linking / Harmony F. Turk and Robert S. Chapkin -- Single-molecule optical methods analyzing receptor tyrosine kinase activation in living cells / Inhee Chung and Ira Mellman -- Evaluation of the dimerization profiles of HER tyrosine kinases by time-resolved Förster resonance energy transfer (TR-FRET) / Evelyne Lopez-Crapez [and three others] -- Applying the proximity ligation assay (PLA) to mouse preimplantation embryos for identifying protein-protein interactions in situ / Ivan Bedzhov and Marc P. Stemmler -- Analysis of receptor tyrosine kinase gene amplification on the example of FGFR1 / Diana Boehm, Anne von Mässenhausen, and Sven Perner -- Quantification of the effects of mutations on receptor tyrosine kinase (RTK) activation in mammalian cells / Lijuan He and Kalina Hristova -- Cell surface biotinylation of receptor tyrosine kinases to investigate intracellular trafficking / Mathieu J.F. Crupi, Douglas S. Richardson, and Lois M. Mulligan -- Studying N-linked glycosylation of receptor tyrosine kinases / Harri M. Itkonen and Ian G. Mills -- Identification of receptor protein tyrosine phosphatases (RPTPs) as regulators of receptor tyrosine kinases (RTKs) using an RPTP siRNA-RTK substrate screen / Hojin Lee and Anton M. Bennett -- Downregulation of receptor tyrosine kinases through ubiquitination : analysis by immunodetection / Noriaki Shimokawa and Noriyuki Koibuchi -- Regulation of receptor tyrosine kinases by miRNA : overexpression of miRNA using lentiviral inducible expression vectors / XiangDong Le, Andrew T. Huang, Yunyun Chen, and Stephen Y. Lai -- Human tumor xenografts in mouse as a model for evaluating therapeutic efficacy of monoclonal antibodies or antibody-drug conjugate targeting receptor tyrosine kinases / Liang Feng [and five others] -- Receptor tyrosine kinase targeting in multicellular spheroids / Susan Breslin and Lorraine O'Driscoll -- Receptor tyrosine kinases and drug resistance : development and characterization of in vitro models of resistance to RTK inhibitors / Claire Corcoran and Lorraine O'Driscoll.
  • 2013 ScienceDirect
    edited by P. Michael Conn.
    This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come.
  • 1979-
    edited by R. D. O'Brien.
    v. 1. General principles and procedures.
  • 1976-
    edited by Jorge R. Pasqualini.
    Status: Not Checked OutLane Catalog Record
  • Google Books
    par Edouard Dulaurier.
    t. 1. Chronologie technique.
    Also available: Print – v. 1, 1859.
  • 2010 Springer
    John F. Atkins, Raymond F. Gesteland, editors.
    Part I. Redefinition -- 1. Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes / Vadim N. Gladyshev and Dolph L. Hatfield -- 2. Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors / Marla J. Berry and Michael T. Howard -- 3. Translation of UAG as Pyrrolysine / Joseph A. Krzycki -- 4. Specification of Standard Amino Acids by Stop Codons / Olivier Namy and Jean-Pierre Rousset -- 5. Ribosome “Skipping”: “Stop-Carry On” or “StopGo” Translation / Jeremy D. Brown and Martin D. Ryan -- 6. Recoding Therapies for Genetic Diseases / Kim M. Keeling and David M. Bedwell -- Part II. Frameshifting - Redirection of Linear Readout -- 7. Pseudoknot-Dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models / Ian Brierley, Robert J.C. Gilbert, and Simon Pennell -- 8. Programmed -1 Ribosomal Frameshift in the Human Immunodeficiency Virus of Type 1 / Léa Brakier-Gingras and Dominic Dulude -- 9. Ribosomal Frameshifting in Decoding Plant Viral RNAs / W. Allen Miller and David P. Giedroc -- 10. Programmed Frameshifting in Budding Yeast / Philip J. Farabaugh -- 11. Recoding in Bacteriophages / Roger W. Hendrix -- 12. Programmed Ribosomal -1 Frameshifting as a Tradition: The Bacterial Transposable Elements of the IS3 Family / Olivier Fayet and Marie-Françoise Prère -- 13. Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals / Ivaylo P. Ivanov and Senya Matsufuji -- 14. Sequences Promoting Recoding Are Singular Genomic Elements / Pavel V. Baranov and Olga Gurvich -- 15. Mutants That Affect Recoding / Jonathan D. Dinman and Michael O'Connor -- 16. The E Site and Its Importance for Improving Accuracy and Preventing Frameshifts / Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, and Knud H. Nierhaus -- Part III. Discontiguity -- 17. Translational Bypassing - Peptidyl-tRNA Re-pairing at Non-overlapping Sites / Norma M. Wills -- 18. trans-Translation / Kenneth C. Keiler and Dennis M. Lee -- Part IV. Transcription Slippage -- 19. Transcript Slippage and Recoding / Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, and William T. McAllister -- Part V. Appendix -- 20. Computational Resources for Studying Recoding / Andrew E. Firth, Michaël Bekaert, and Pavel V. Baranov.
  • pt. A-B, 2003. ScienceDirect
    pt. B ScienceDirect
    edited by Yuan C. Lee, Reiko T. Lee.
    Also available: Print – pt. A-B, 2003.
  • 2012
    Christina Meyer.
    The adaptive immune system is composed of [alpha beta] T cells, [gamma delta] T cells, and B cells, all of which express diverse rearranged antigen receptors and have been conserved together through evolution. [gamma delta] T cells make up the minority of circulating T cells and perform many of the same effector functions as [alpha beta] T cells, including cytotoxic functions and the production of cytokines like IL-17, IFN-[gamma], and IL-4. However, the conservation of [gamma delta] T cells suggests that they fill a non-redundant role in the adaptive immune system. Because their functions overlap, it is likely that [gamma delta] T cells are distinctive from [alpha beta] T cells in the way they are triggered by antigen. These antigenic triggers of [gamma delta] T cells remain poorly defined, but a more thorough knowledge of this repertoire will enhance understanding of the role of [gamma delta] T cells in the immune response. The identification of new [gamma delta] T cell antigens was undertaken, resulting in the discovery of hapten small molecule [gamma delta] T cell ligands and the identification of a diverse group of additional candidate [gamma delta] T cell ligands. With the discovery that [gamma delta] T cell receptors can recognize small molecules in addition to their known large protein ligands, it is clear that [gamma delta] T cells fill a unique role in the adaptive immune system is solidified with a broad capacity for antigen recognition along with all the functionality of T cells, and are uniquely situated to function together with [alpha beta] T cells and B cells in a concerted antigen-specific response.
  • 2014 ScienceDirect
    by Leon Chaitow, Christopher Gilbert, Dinah Bradley.
    This book is intended to help practitioners understand the causes and effects of disordered breathing and to provide strategies and protocols to help restore normal function. Fully updated throughout, this volume has been completely revised to guide the practitioner in the recognition of breathing pattern disorders and presents the latest research findings relating to the condition including a range of completely new techniques - many from an international perspective - to help restore and maintain normal functionality. Video clips on an associated website presents practical examples of the breathing techniques discussed in the book. Carefully prepared by a global team of renowned experts under the guidance of Leon Chaitow Focuses on practical, validated, and clinically relevant information Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Contains clinical cases to ensure full comprehension of the topics explored Suitable for physiotherapists, manual therapists, physical therapists, osteopaths, osteopathic physicians and chiropractors, massage therapists, Pilates and yoga teachers & therapists, Tai chi and Feldenkrais practitioners, athletic coaches and voice-coaches.
  • 2011
    Wang Rui.
    How the human brain processes phonemes has been a subject of interest for linguists and neuroscientists for a long time. Electroencephalography (EEG) offers a promising approach to observe neural activities of phoneme processing in the brain, thanks to its high temporal resolution, low cost and noninvasiveness. The studies on Mismatch Negativity (MMN) effects in EEG activities in the 1990s suggested the existence of a language-specific central phoneme representation in the brain. Recent findings using magnetoencephalograph (MEG) also suggested that the brain encodes the complex acoustic-phonetic information of speech into the representations of phonological features before the lexical information is retrieved. However, very little success has yet been reported in classifying the brain activities associated with phoneme processing. In my work, I proposed a classification framework which incorporates Principal Components Analysis (PCA), cross-validation and support vector machine (SVM) methods. The initial classification rates were not very good. Progress was made by using bootstrap aggregation (Bagging) scheme and introducing phase calculations. To calculate phase, I computed the Discrete Fourier Transform (DFT) of the original time-domain signal and kept the angles of the finite sample of frequencies. The resulting EEG spectral representation contains only the phase and frequency information and ignores the amplitudes. Using this method, the accurate rate of classifying averaged test samples of eight consonants improved from 41% to 51%. Furthermore, the qualitative analysis of the similarities between the EEG representations, derived from the confusion matrices, illustrates the invariance of brain and perceptual representation of phonemes. For brain and perceptual representation of consonants, voicing is the most distinguishable feature among voicing, continuant and place of articulation. And the feature vowel-height is more robust than vowel-backness in both brain and perceptual representation of vowels. By extending and further refining these methods, it is likely significant classification of other phonemes and features can be made.
  • 2012 Springer Protocols
    edited by Graeme L. Conn.
    Purification of RNA expressed in vivo inserted in a tRNA scaffold / Luc Ponchon and Frederic Dardel -- Selective RNase H cleavage of target RNAs from a tRNA scaffold / Luc Ponchon [and others] -- Preparation of long templates for RNA in vitro transcription by recursive PCR / Jessica C. Bowman [and others] -- General protocols for preparation of plasmid DNA template, RNA in vitro transcription, and RNA purification by denaturing PAGE / Jo L. Linpinsel and Graeme L. Conn -- Preparation of short RNA by in vitro transcription / Cheng Lu and Pingwei Li -- Native RNA purification by gel filtration chromatography / Evan P. Booy, Hui Meng, and Sean A. McKenna -- Cis-acting ribozymes for the production of RNA in vitro transcripts with defined 5ʹ and 3ʹ ends / Johanna M. Avis, Graeme L. Conn, and Scott C. Walker -- Trans-acting antigenomic HDV ribozyme for production of in vitro transcripts with homogenous 3ʹ ends / Milena Szafraniec [and others] -- Rapid preparation of RNA samples using DNA-affinity chromatography and DNAzyme methods / Hae-Kap Cheong, Eunha Hwang, and Chaejoon Cheong -- Preparation of lN-GST fusion protein for affinity immobilization of RNA / Genevieve Di Tomasso [and others] -- Affinity purification of RNA using an ARiBo tag / Genevieve Di Tomasso [and others] -- Plasmid template design and in vitro transcription of short RNAs within a "structure cassette" for structure probing experiments / Virginia K. Vachon and Graeme L. Conn -- In vitro transcription of modified RNAs / Stephanie L. Moon and Jeffrey Wilusz -- End-labeling oligonucleotides with chemical tags after synthesis / N. Ruth Zearfoss and Sean P. Ryder -- High-purity enzymatic synthesis of site-specifically modified tRNA / Ya-Ming Hou -- Se-derivatized RNAs for x-ray crystallography / Lina Lin and Zhen Huang -- Biosynthetic preparation of 13C/15N-labeled rNTPs for high-resolution NMR studies of RNAs / Luigi Martino and Maria R. Conte -- Preparative separation of ribonucleoside monophosphates by ion-pair reverse-phase HPLC / Pierre Dagenais and Pascale Legault -- Splint ligation of RNA with T4 DNA ligase / Christopher J. Kershaw and Raymond T. O'Keefe.
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1979
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman, Kivie Moldave.
    Also available: Print – 1983
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman, Kivie Moldave.
    Also available: Print – 1983
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu, Lawrence Grossman.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1987
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1992
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1993
  • ScienceDirect
    edited by Ray Wu.
    Also available: Print – 1993
  • 2012 Springer Protocols
    edited by Argelia Lorence.
    Using folding promoting agents in recombinant protein production : a review / Beatrix Fahnert -- Routine identity confirmation of recombinant proteins by MALDI-TOF mass spectrometry / Brett J. Savary and Prasanna Vasu -- A matter of packaging : influence of nucleosome positioning on heterologous gene expression / María de la Cruz Muñoz-Centeno, Gonzalo Millán-Zambrano, and Sebastián Chávez -- Tools of the trade : developing antibody-based detection capabilities for recombinant proteins / Maureen C. Dolan [and others] -- Heat-shock protein fusion vectors for improved expression of soluble recombinant proteins in Escherichia coli / Christos A. Kyratsous and Christos A. Panagiotidis -- The use of a flagellar export signal for the secretion of recombinant proteins in salmonella / Ferenc Vonderviszt [and others] -- Optimization of purification protocols based on the step-by-step monitoring of the protein aggregates in soluble fractions / Ario de Marco -- Heterologous protein expression by Lactococcus lactis / Julio Villator-Hernández [and others] -- An extended suite of genetic tools for use in bacteria of the halomonadaceae : an overview / Montserrat Argandoña [and others] -- Regulated recombinant protein production in the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Valentina Rippa [and others] -- A novel strategy for the construction of genomic mutants of the antarctic bacterium Pseudoalteromonas haloplanktis TAC125 / Maria Giuliani [and others] -- A new bacterial co-expression system for over-expressing soluble protein and validating protein-protein interaction / Jumei Zeng and Zheng-Guo He -- Heterologous high-level gene expression in the photosynthetic bacterium Rhodobacter capsulatus / Nadine Katzke [and others] -- Plasmid DNA production for therapeutic applications / Alvaro R. Lara and Octavio T. Ramírez -- Recombinant protein production in the eukaryotic protozoan parasite Leishmania tarentolae : a review / Tomoaki Niimi -- Expression of multisubunit proteins in Leishmania tarentolae / Marisa Sugino and Tomoaki Niimi -- Recombinant protein production in yeasts / Diethard Mattanovich [and others] -- Yeasts as a tool for heterologous gene expression / Raja Mokdad-Gargouri [and others] -- The Cre/Lox system : a practical tool to efficiently eliminate selectable markers in fungal endophytes / Simona Florea [and others] -- Aptamer-regulated expression of essential genes in yeast / Beatrix Suess [and others] -- Cloning and expression of hemicellulases from Aspergillus nidulans in Pichia pastoris / Prasanna Vasu, Stefan Bauer, and Brett J. Savary -- A thiamine-regulatable epitope-tagged protein expression system in fission yeast / Tiina Tamm -- Heterologous gene expression by chromosomal integration in fission yeast / Akihisa Matsuyama and Minoru Yoshida -- Genetic engineering of industrial strains of Saccharomyces cerevisiae / Sylvie le Borgne -- Recombinant protein production in plants : challenges and solutions / Elizabeth E. Hood and Deborah V. Vicuna Requesens -- A novel plant cell bioproduction platform for high-yield secretion of recombinant proteins / Jianfeng Xu and Marcia J. Kieliszewski -- Super-promoter :TEV, a powerful gene expression system for tobacco hairy roots / Luis Ñopo [and others] -- Bioseparation of recombinant proteins from plant extract with hydrophobin fusion technology / Jussi J. Joensuu [and others] -- Quality assessment of recombinant proteins produced in plants / Giuliana Medrano [and others] -- Cell-free protein synthesis as a promising expression system for recombinant proteins / Xumeng Ge and Jianfeng Xu -- The use of bacterial artificial chromosomes for recombinant protein production in mammalian cell lines / Leander Blaas [and others] -- Engineering the chaperone network of CHO cells for optimal recombinant protein production and authenticity / Lyne Jossé, C. Mark Smales, and Mick F. Tuite -- High-throughput baculovirus expression in insect cells / Richard B. Hitchman, Robert D. Possee, and Linda A. King -- Recombinant protein expression in milk of livestock species / Zsuzsanna Bösze and László Hiripi.
  • 2012 Springer Protocols
    edited by Roslyn M. Bill.
    Optimising yeast as a host for recombinant protein production (review) / Nicklas Bonander and Roslyn M. Bill -- Which yeast species shall I choose? : Saccharomyces cerevisiae versus Pichia pastoris (review) / Richard A.J. Darby [and others] -- Preparation of Pichia pastoris expression plasmids / Christel Logez [and others] -- Preparation of Saccharomyces cerevisiae expression plasmids / David Drew and Hyun Kim -- Codon optimisation for heterologous gene expression in yeast / Kristina Hedfalk -- Yeast transformation to generate high-yielding clones / Mohammed Jamshad and Richard A.J. Darby -- Screening for high-yielding Pichia pastoris clones : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Screening for high-yielding Saccharomyces cerevisiae clones: using a green fluorescent protein fusion strategy in the production of membrane proteins / David Drew and Hyun Kim -- The effect of antifoam addition on protein production yields / Sarah J. Routledge and Roslyn M. Bill -- Setting up a bioreactor for recombinant protein production in yeast / Sarah J. Routlledge and Michelle Clare -- The implementation of a design of experiments strategy to increase recombinant protein yields in yeast (review) / Nagamani Bora [and others] -- Online analysis and process control in recombinant protein production (review) / Shane M. Palmer and Edmund R.S. Kunji -- Monitoring the biomass accumulation of recombinant yeast cultures : offline estimations of dry cell mass and cell counts / Shane M. Palmer and Edmund R.S. Kunji -- Online monitoring of biomass accumulation in recombinant yeast cultures / Shane M. Palmer and Edmund R.S. Kunji -- Optimising Pichia pastoris induction / Zharain Bawa and Richard A.J. Darby -- Optimizing Saccharomyces cerevisiae induction regimes / David Drew and Hyun Kim -- Large-scale production of membrane proteins in Pichia pastoris : the production of G protein-coupled receptors as a case study / Shweta Singh [and others] -- Large-scale production of secreted proteins in Pichia pastoris / Nagamani Bora -- Disruption of yeast cells to isolate recombinant proteins / Mohammed Jamshad and Richard A.J. Darby.
  • 2009 Springer Protocols
    edited by Loïc Faye and Véronique Gomord.
    From Neanderthal to nanobiotech : from plant potions to pharming with plant factories / Christophe Sourrouille ... [et al.] -- Cowpea mosaic virus-based systems for the expression of antigens and antibodies in plants / Frank Sainsbury, Li Liu, and George P. Lomonossoff -- Transient expression of antibodies in plants using syringe agroinfiltration / Marc-André D'Aoust ... [et al.] -- Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants / Giuliana Medrano ... [et al.] -- Production and localization of recombinant pharmaceuticals in transgenic seeds / Thomas Rademacher, Elsa Arcalis, and Eva Stoger -- Production of antibody fragments in Arabidopsis seeds / Bart Van Droogenbroeck, Kirsten De Wilde, and Ann Depicker -- Production of plantibodies in Nicotiana plants / Marta Ayala ... [et al.] -- Physcomitrella patens : a non-vascular plant for recombinant protein production / David Liénard and Fabien Nogué -- Production of recombinant proteins in suspension-cultured plant cells / Carole Plasson ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals : protocols for expression, purification, or oral delivery and functional evaluation / N. Dolendro Singh, Yi Ding, and Henry Daniell -- Protein body induction : a new tool to produce and recover recombinant proteins in plants / Margarita Torrent, Imma Llop-Tous, and M. Dolors Ludevid -- A case study for plant-made pharmaceuticals comparing different plant expression and production systems / Guy Vancanneyt ... [et al.] -- Glycosylation of antibody therapeutics : optimisation for purpose / Roy Jefferis -- N-glycosylation of plant recombinant pharmaceuticals / Muriel Bardor ... [et al.] -- Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts / Meriem Benchabane ... [et al.] -- Strategies for improving vaccine antigens expression in transgenic plants : fusion to carrier sequences / Jose M. Escribano and Daniel M. Perez-Filgueira -- Immunomodulation of plant function by in vitro selected single-chain Fv intrabodies / Manfred Gahrtz and Udo Conrad -- On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI-TOF MS / Amine M. Badri ... [et al.] -- Assessing the risk of undesirable immunogenicity/allergenicity of plant-derived therapeutic proteins / Paul D. Chamberlain -- Biosafety, risk assessment, and regulation of plant-made pharmaceuticals / Penelope A.C. Sparrow and Richard M. Twyman.
  • 2008 Springer
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    "Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Anibidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume."--Jacket.
  • 2008 Springer
    volume editors, Richard Egel, Dirk-Henner Lankenau.
    Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm - in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillar.
  • 2007
    guest editors: Robert H. Dworkin, Robert W. Johnson, Judith Breuer ... [and others].
  • 2007
  • CDC
  • 2006
    Frederic Lawrence Holmes ; edited by William C. Summers.
    Status: Not Checked OutLane Catalog Record
    Classical mendelian genetics -- Genetics and the phage biologists -- The physicist becomes a phage biologist -- To Paris and back -- Teaching and research at Purdue -- Entering the rII region -- Crossing into the fine structure -- Is gene a dirty word? -- The survival of the "gene".
  • 2014 ScienceDirect
    edited by Ron Vale ; contributors Anna Akhmanova [and seven nine others].
    Actin filament dynamics using microfluidics -- Bacterial actin-like proteins: purification and characterization of self-assembly properties -- Quantitative analysis of microtubule self-assembly kinetics and tip structure -- Biochemical reconstitution of the WAVE regulatory complex -- Rotational movement of formins evaluated by using single-molecule fluorescence polarization -- Single-molecule studies of actin assembly and disassembly factors -- Assaying microtubule nucleation of the [gamma]-Tubulin ring complex -- Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins -- Generation of differentially modified microtubules using In Vitro enzymatic approaches -- Engineering defined motor ensembles with DNA origami -- Construction and analyses of elastically coupled multiple-motor systems -- Reconstitution of cortical dynein function -- Reconstitution of microtubule-dependent organnelle transport -- Reconstituting the motility of isolated intracellular cargoes -- Reconstitution of contractile actomyosin arrays -- Directed actin assembly and motility -- In Vitro reconstitution of dynamic microtubules interacting with actin filament networks -- Measuring kinetochore-microtubule interaction In Vitro -- Micropattern-guided assembly of overlapping pairs of dynamic microtubules -- WAVE regulatory complex activation -- Dissecting principles governing actin assembly using yeast extracts -- Xenopus egg ctyoplasm with intact actin -- Glycogen-supplemented mitotic cytosol for analyzing xenopus egg microtubule organization -- Spindle assembly on immmobilized chromatin micropatterns.
  • ScienceDirect
    edited by James E. Rothman.
    Also available: Print – 1992
  • 2013
    Murray C. Meikle.
    "The two world wars played an important role in the evolution of plastic and maxillofacial surgery in the first half of the 20th century. This book is about four of the key figures involved. Sir Harold Gillies and Sir Archibald McIndoe were born in Dunedin; McIndoe and Rainsford Mowlem studied medicine at the University of Otago Medical School, and Henry Pickerill was foundation Dean of the University of Otago Dental School. The author describes how these surgeons revolutionised plastic surgery and the treatment of facial trauma, working on soldiers, fighter pilots and civilians disfigured by bombs, shrapnel and burns. Eventually Gillies et al. were supported by a vast surgical enterprise that included surgeons, dentists, anaesthetists, artists and photographers, nurses and orderlies. The text is fully illustrated with photos, drawings and case notes by the surgeons and war artists at military hospitals at Boulogne-sur-Mer, Aldershot and Sidcup in the First World War, and civilian hospitals at East Grinstead, Basingstoke and Hill End in the Second. The book includes a DVD of Rainsford Mowlem performing a variety of plastic operations in 1945. This book is a must for anyone interested in the history of medicine and the treatment of casualties in the two world wars"--From publisher.
  • 2007 CRCnetBASE
    edited by Trevor R. Hodkinson, John A.N. Parnell.
    section A. Introduction and general context -- section B. Reconstructing and using the tree of life -- section C. Taxonomy and systematics of species rich groups (case studies).
  • 2011 Springer
    Petr Suchomel, Ondřej Choutka ; with contributions by Jan Hradil ... [et al.].
    Surgical anatomy -- Biomechanical remarks -- Special radiology -- Surgical approaches -- Basic principles of reconstruction techniques -- Specific reconstruction techniques of upper cervical spine and craniovertebral junction -- Virtual and real time navigational techniques -- Traumatic atlantooccipital dislocation (AOD) -- Occipital condyle fractures -- Atlas fractures -- Odontoid process fractures -- Fractures of the ring of axis (hangman type fractures) -- Miscellaneous C2 fractures -- Multiple fractures of axis and atlas-axis fracture combinations -- Acute traumatic atlantoasial dislocation (AAD) in adults -- Posttraumatic deformity -- Non-specific inflammation -- Rheumatoid arthritis -- Tumors -- Congenital and developmental abnormalities -- Degenerative disorders -- Surgical failures.
  • 2010 ClinicalKey
    Mark S. Myerson.
    World-renowned surgeon Dr. Mark S. Myerson returns with a Second Edition of Reconstructive Foot and Ankle Surgery. This surgical technique reference delivers step-by-step guidance on the essential elements of complex foot and ankle surgery and is packed with full-color illustrations, pearls, and pitfalls. New chapters focus on the complications management of complications, aimed to help you select the right procedure for challenging conditions to ensure optimal outcomes. Learn from one of the very best - world-renowned surgeon Dr. Mark S. Myerson shares his innovative approaches to the reconstructive surgical techniques and complications management most frequently seen in practice. Quickly reference essential topics with a templated, focused format emphasizing procedures rather than basic science.
  • 2015 Springer
    Salah Rubayi ; with contributions by Burl R. Wagenheim and Alicia Mcleland.
  • 2016 Thieme-Connect
    Matthew M. Hanasono, Geoffrey L. Robb, Roman J. Skoracki, Peirong Yu.
  • 2013 Springer
    Andrew P. Zbar, Robert D. Madoff, Steven Wexner, editors.
    Reconstructive Surgery of the Rectum, Anus and Perineum provides the reader with a didactic discussion of complex problems which require re-operative surgery; including details of preoperative investigation, postoperative follow-up and a detailed operative approach. This comprehensive and detailed text uses a formulated algorithm approach to these complicated cases using operative photographs and composite explanatory line drawings which complement 'how-to' guides in describing the operative technical tips and pitfalls from experienced commentators. Reconstructive Surgery of the Rectum, Anus and Perineum, is written by leading world experts in the field of colorectal surgery and is a valuable and timely resource for colorectal surgeons and colorectal trainees alike. In addition, general surgeons will be interested in the specialist nature of dealing with difficult colorectal complications dealt with in this unique textbook.
  • 2008 Springer
    edited by Bradley J. Adams and John E. Byrd.
  • 2010 Springer
    edited by Brian G. Czito, Christopher G. Willett.
  • 2005 Springer
    [edited by] Gian Gaetano Delaini ; foreword by R.J. Nicholls.
  • 2013 Springer
    Nicolò de Manzini, editor ; forewords by Gianluigi Melotti, Christiam Meyer.
    This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
  • 2005 Springer
    M.W. Büchler, R.J. Heald, B. Ulrich, J. Weitz (eds.).
    Also available: Print – 2005
  • 2008 Springer
    Donato F. Altomare, Filippo Pucciani (eds.).
  • 2016 Springer
    Gregory W. Randolph, editor.
  • 2015 Springer
    Helena M. Tabery.
    This book on the morphology of corneal surface changes in recurrent erosion syndrome and epithelial edema presents high-magnification images captured in vivo by the method of non-contact photomicrography. Part I of the book, on recurrent erosion syndrome, displays images covering a broad spectrum of epithelial changes, including manifestations of the ongoing underlying pathological process and epithelial activity aimed at elimination of abnormal elements and repair. The dynamics of the interplay between these opposing forces are captured in sequential photographs that are invaluable for interpretation. Case reports illustrate typical features of the disease and document the variability of symptoms and findings in the same individual over time. Also included are images of the appearance and dynamics of corneal stromal infiltrates, a rare but potentially sight-threatening complication. Part II of the book demonstrates typical features of corneal epithelial edema and also covers the occasional contemporaneous occurrence, and dynamics, of various phenomena indistinguishable from those commonly seen in recurrent erosion syndrome. Again, informative case reports are included. The in vivo images displayed in this book, obtained at a higher magnification than that used in standard photography, reveal additional details of epithelial changes. The presented morphology will facilitate understanding of clinical appearances and assist in differential diagnosis.
  • 2007 Springer
    Volker Schumpelick, Robert J. Fitzgibbons (eds.).
  • 2016 Springer
    Asher Bashiri, Avi Harlev, Ashok Agarwal, editors.
    Part I: Introduction to Recurrent Pregnancy Loss -- Recurrent pregnancy loss: definitions, epidemiology, and prognosis -- Implantation, Physiology of Placentation -- Part II: Causes of Recurrent Pregnancy Loss -- Endocrine abnormalities in RPL -- Genetics of recurrent pregnancy loss -- Inherited and Acquired Thrombophilias and Adverse Pregnancy Outcomes -- Immunological causes of recurrent pregnancy loss -- Anatomical aspects in recurrent pregnancy loss -- Male Factors in Recurrent Pregnancy Loss -- Lifestyle and RPL -- The common characteristics between Infertility and recurrent pregnancy loss -- Part III: Management of Recurrent Pregnancy Loss. Contemporary Prevention and treatment of recurrent pregnancy loss -- Part IV: Psychological and Supporting Aspects of Recurrent Pregnancy Loss -- The healthcare giver's perspective -- The importance of emotional support for women with recurrent RPL -- A Patient's Perspective -- Part V: The Future -- New Frontiers in RPL research and treatment.
  • 2012 CRCnetBASE
    Oguz K. Baskurt, Bjorn Neu, Herbert J. Meiselman.
    Ch. 1. Introduction -- ch. 2. Determinants of red blood cell aggregation -- ch. 3. Mechanism of red blood cell aggregation -- ch. 4. Measurement of red blood cell aggregation -- ch. 5. Effect of red blood cell aggregation on in Vitro blood rheology -- ch. 6. Effect of red blood cell aggregation on tube flow -- ch. 7. In Vivo hemodynamics and red blood cell aggregation -- ch. 8. Alterations in red blood cell aggregation -- ch. 9. Comparative aspects of red blood cell aggregation.
  • Silverchair
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Also available: Print – 1970-<2012>
  • 2011
    Scott Carney.
    Status: Not Checked OutLane Catalog Record
    A shocking tour through a macabre global underworld where organs, bones, and live people are bought and sold on the red market. Investigative journalist Scott Carney has spent five years tracing the lucrative and deeply secretive trade in human bodies and body parts. The Red Market reveals the rise, fall, and resurgence of this multibillion-dollar underground trade through history, from early medical study and modern universities to poverty-ravaged Eurasian villages and high-tech Western labs; from body snatchers and surrogate mothers to skeleton dealers and the poor who sell body parts to survive. While local and international law enforcement have cracked down on the market, advances in science have increased the demand for human tissue--ligaments, kidneys, even rented space in women's wombs--leaving little room to consider the ethical dilemmas inherent in the flesh-and-blood trade--From publisher description.
  • 2011
    Kimberly Allison.
    "Dr. Kimberly Allison diagnoses breast cancer for a living. But as a 33-year-old healthy new mother, she never expected to find herself looking at her own malignant cells under the microscope. Like many others diagnosed with cancer, Dr. Allison was starving for stories of other survivors. She wanted to hear someone's tale, to feel their experiences and look for hidden clues to what her own future might hold. Ultimately, the story that Dr. Allison was looking for was found in her own life. Red Sunshine is a memoir about Dr. Allison's sudden journey from physician to patient and her attempt to make the most of this terrifying and unexpected ordeal. Her experience reflects the incredible power of the bonds of friendship and family. It is about paying attention to the magic that is waiting to be uncovered in everyday life. Red Sunshine is an uplifting story of survival in which Dr. Allison shares all the intimate details of her emotional journey with both humor and honesty"-- Provided by publisher.
  • 2013
    by Heidi M. Feldman.
    Status: Not Checked OutLane Catalog Record
    What are disabilities? -- Why focus on children with disabilities? -- What are the challenges in delivering health care to children with disabilities? -- Inclusion -- Contribution -- Health -- Focusing health care on function -- Comprehensive integrated care plans -- Family- and person-centered care -- Care coordination / with Alexis Hansen -- Changing professional education -- Research / with Nathan J. Blum -- Public policy.
  • 2012 Springer
    Venkat R. Machiraju, Hartzell V. Schaff, Lars G. Svensson, editors.
  • 2014 ScienceDirect
    edited by Danyelle M. Townsend, Kenneth D. Tew.
    Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz -- Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki -- Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan -- Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend -- A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper -- Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik -- Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang -- Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.
  • pt. A-B, 2002. ScienceDirect
    pt. B ScienceDirect
    edited by Chandan K. Sen, Lester Packer ; editorial advisory board, John F. Engelhardt ... [et al.].
    Also available: Print – pt. A-B, 2002.
  • 2006
    edited by Isabella Dalle-Donne, Andrea Scaloni, and D. Allan Butterfield.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by Judith P. Klinman.
    Also available: Print – 1995
  • 2008 Springer Protocols
    edited by John T. Hancock.
    The role of redox in signal transduction / John T. Hancock -- The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence / Andrew G. Pinder ... [et al.] -- Detection and measurement of reactive oxygen intermediates in mitocondria and cells / Matthew Whiteman ... [et al.] -- Redox-sensitive green fluorescent protein : probes for dynamic intracellular redox responses : a review / Mark B. Cannon and S. James Remington -- Measuring redox changes in vivo in leaves : prospects and technical challenges / Philip M. Mullineaux and Tracy Lawson -- Imaging of intracellular hydrogen peroxide production with hyper upon stimulation of hela cells with Egf / Kseniya N. Markvicheva ... [et al.] -- Tools to investigate ROS sensitive signalling proteins / Radhika Desikan ... [et al.] -- Methods for preparing crystals of reversibly oxidized proteins : crystallization of protein tyrosine phophatase 1b as an example / Annette Salmeen and David Barford -- Methods for the study of redox-mediated changes in p53 structure and function / Kristine Mann -- Redox regulation and trapping sulphenic acid in the peroxide sensitive human mitochondrial branched chain aminotransferase / Susan M. Hutson ... [et al.] -- Detection of carbonylated proteins in 2-D SDS page separations / Rukhsana Sultana ... [et al.] -- Analysis of global and specific changes in the disulfide proteome using redox 2D-PAGE / Robert C. Cumming -- Protein-thiol oxidation from single proteins to proteome-wide analyses / Natacha Le Moan, Frédérique Tacnet, and Michel B. Toledano -- Analysis of redox relationships in the plant cell cycle : determinations of ascorbate, glutathione, and poly (ADPribose) polymerase (PARP) in plant cell cultures / Christine H. Foyer ... [et al.] -- Generation and detection of S-nitrosothiols / Christian Lindermayr, Simone Sell, and Jörg Durner.
  • 2014 Springer
    Toshiyuki Mori, Giovanni Dapri, editors.
    Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments. Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.
  • Suzanne H. Reuben for the The President's Cancer Panel.
  • 2015 Springer
    Giovanni Landoni, Marta Mucchetti, Alberto Zangrillo, Rinaldo Bellomo, editors.
  • 2014 Springer
    Giovanni Landoni, Laura Ruggeri, Alberto Zangrillo, editors.
    This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists.
  • 2011 Springer
    Arden Handler, Joan Kennelly, Nadine Peacock, editors.
    Introduction: challenges in reducing disparities in reproductive and perinatal outcomes through evidence-based public health -- Methodological approach to assessing the evidence -- Evidence-based public health: origins, assumptions, and cautions -- Access to family planning and induced abortion -- Preconceptional health promotion -- Infertility status and infertility treatment: racial and ethnic disparities -- Public health interventions for perinatal HIV and STI screening in pregnancy -- What is the role of prenatal care in reducing racial and ethnic disparities in pregnancy outcomes? -- Current approaches to reducing premature births and implications for disparity elimination -- Prenatal case management of pregnant women: what is the evidence for its contribution to a reduction of disparities in perinatal outcomes? -- Behavioral treatment methods for pregnant smokers: the evidence base for prenatal care programs and professional practice -- Substance abuse in pregnancy: the impact of screening and treatment on improving perinatal outcomes and reducing racial and ethnic disparities -- The evidence for perinatal depression screening and treatment -- Supplemental nutrition programs during pregnancy and the early postnatal period -- Group prenatal care and doula care for pregnant women -- Contemporary childbirth in the United States: interventions and disparities -- Regionalized perinatal care: an evidence-based intervention in development.
  • 2013 R Soc Chem
    edited by David G. Allen and Michael D. Waters.
    Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • 2015 Springer
    Raj Mathur, editor.
    1. The Challenges of Multiple Pregnancies -- 2. Prognosis of Risks for Offspring of Fertility Treatment -- 3. Ovarian Hyperstimulation Syndrome -- 4. Thromboembolism Associated with Fertility Treatment -- 5. Emotional and Psychosocial Risk Associated with Fertility Treatment -- 6. Regulatory and Legal Risks for Patients.
  • 2012 ClinicalKey
    volume editors, Matthew T. Ranson, Jason E. Pope.
    Complications of Spinal Cord Stimulation -- Complications of Peripheral Nerve Stimulation : Open Technique, Percutaneous Technique, and Peripheral Nerve Field Stimulation -- Complications of Cranial Nerve Stimulation -- Avoidance, Recognition, and Treatment of Complications in Cranial Neuromodulation for Pain -- Complications of Intrathecal Drug Delivery Systems -- Complications of Therapeutic Minimally Invasive Intradiscal Procedures -- Complications Related to Radiofrequency Procedures for the Treatment of Chronic Pain -- Complications of Lumbar Spine Fusion Surgery -- Complications of Nucleus Replacement and Motion-Sparing Technologies -- Complications of Spinal Injections and Surgery for Disc Herniation -- Radiation Safety and Complications of Fluoroscopy, Ultrasonography, and Computed Tomography -- Complications Associated with Head and Neck Blocks, Upper Extremity Blocks, Lower Extremity Blocks, and Differential Diagnostic Blocks -- Complications of Epidural Injections -- Complications of Facet Joint Injections and Medial Branch Blocks -- Complications of Radiofrequency Rhizotomy for Facet Syndrome -- Complications of Sacroiliac Joint Injection and Lateral Branch Blocks, Including Water-Cooled Rhizotomy -- Complications of Percutaneous Vertebral Augmentation : Vertebroplasty and Kyphoplasty -- Complications of Intraarticular Joint Injections and Musculoskeletal Injections.
  • 2007 CRCnetBASE
    edited by David Kilcast and Fiona Angus.
    pt. 1. Dietary salt, health and the consumer -- pt. 2. Strategies for salt reduction in food products -- pt. 3. Reducing salt in particular foods.
  • 2015
    Jeffrey Levi, Laura M. Segal, Anne De Blasi, Alejandra Martin.
    In this report, the Trust for America's Health (TFAH) examines how to help move towards a strong prevention-oriented, continuum-of-care approach to substance misuse -- looking at policies and programs that have a high impact for improving the well-being of America's youth. Section 1 reviews 10 examples of important policy indicators or programs that states may have in place that can have an impact on the well-being of children and youth and/or have been connected with preventing and reducing youth substance misuse. The indicators reflect a range of types of policies that support a prevention-intervention-treatment approach -- from supporting healthier schools and communities to limiting access to substances to providing positive support and treatment. Section 2 featuers recommendations for modernizing the nation's strategy for addressing youth substance misuse by imprementing a research-based public health approach.
  • NLM
    Also available: Print – 1989
  • 2008 Springer
    edited by S.H. Fatemi.
  • 2005 Springer
    edited by K.R.H. von Wild in cooperation with G.A. Brunelli.
    Also available: Print – 2005
  • 2006
    Kay Ann Cassell and Uma Hiremath.
    Status: Not Checked OutLane Catalog Record
  • 2012 Springer
    edited by Rainer Hofmann-Wellenhof, Giovanni Pellacani, Joseph Malvehy, Hans Peter Soyer.
    Part 1. Confocal Reflectance Microscopy - the Essentials -- The Confocal Story -- How Reflectance Confocal Microscopy Works -- A Hands-on Guide to Confocal Imaging -- Part 2. Normal Skin -- Epidermis, Dermis and Epidermal Appendages -- Acral Volar Skin, Facial Skin and Mucous Membrane -- Part 3. Melanocytic lesions -- Semeiology and Pattern Analysis in Melanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Part 4. Melanocytic lesions: Nevi -- Common Nevi -- Atypical/Dysplastic Nevi -- Spitz Nevi -- In Vivo Confocal Reflectance Microscopy of Congenital Melanocytic Nevi -- The Many Faces of Nevi: Blue, "Black" and Recurrent Nevi -- Part 5. Melanocytic lesions: Melanoma -- Superficial Spreading Melanoma -- Melanoma Progression -- Nodular Melanoma -- Lentigo Maligna -- Amelanotic Melanoma -- Part 6. Non-melanocytic Skin Lesions -- Semiology and Pattern Analysis in Nonmelanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Solar Lentigo, Seborrheic Keratosis and Lichen Planus-Like Keratosis -- Basal Cell Carcinoma -- Actinic Keratosis -- Squamous Cell Carcinoma -- Cutaneous Lymphoma -- Potpourri of Nonmelanocytic Skin Lesions -- Part 7. Inflammatory Skin Diseases -- The Semiology and Patterns of Inflammatory Skin Conditions -- Hyperkeratotic Dermatitis -- Spongiotic Dermatitis -- Interface Dermatitis -- Pigmentary Skin Disorders -- Part 8. Monitoring of Skin Lesions and Therapy Control -- Follow-up of Nevi -- Monitoring of Nonsurgical Treatment of Skin Tumors -- Confocal Mosaicing Microscopy in Skin Excisions: Feasibility of Cancer Margin Screening at the Bedside to Guide Mohs Surgery -- Reflectance Confocal Microscopy Applications in Cosmetology -- Part 9. Future Aspects -- Tele-Reflectance Confocal Microscopy -- Automated Diagnosis and Reflectance Confocal Microscopy -- Experimental Applications and Future Directions -- Part 10. Glossary -- Reflectance Confocal Microscopy Imaging: A Glossary of Terminology.
  • 2002 HighWire
    edited by S. Kaul and A. Lahiri.
    Also available: Print – 2002
  • 2005 Springer
    editors, I. Howard Fine, Mark Packer, Richard S. Hoffman.
    Ch. 1 Crystalline lens as a target for refractive surgery -- Ch. 2 Refractive lens exchange as a refractive surgery modality -- Ch. 3 Biometry for refractive lens surgery -- Ch. 4 Intraocular lens power calculations: correction of defocus -- Ch. 5 IOL calculations following keratorefractive surgery -- Ch. 6 Correction of keratometric astigmatism: incisional surgery -- Ch. 7 STAAR toric IOL -- Ch. 8 Correction of keratometric astigmatism: AcrySof toric IOL -- Ch. 9 Wavefront technology of spherical aberration -- Ch. 10 The Eyeonics Crystalens -- Ch. 11 Presbyopia - cataract surgery with implantation of the accommodative posterior chamber lens ICU -- Ch. 12 Synchrony IOL -- Ch. 13 Sarfarazi elliptical accommodative intraocular lens -- Ch. 14 AcrySof ReStor pseudo-accommodative IOL -- Ch. 15 The Tecnis Multifocal IOL -- 16 Blue-light-filtering intraocular lenses -- Ch. 17 The light-adjustable lens -- Ch. 18 Injectable polymer -- Ch. 19 The vision membrane -- Ch. 20 Bimanual ultrasound phacoemulsification -- Ch. 21 Low ultrasound microincision cataract surgery -- Ch. 22 The Infiniti Vision System -- Ch. 23 The Millenium -- Ch. 24 The Staar Sonic Wave -- Ch. 25 AMO Sovereign with WhiteStar Technology -- Ch. 26 Refractive lens exchange in high myopia: weighing the risks -- Ch. 27 Conclusion: the future of refractive lens surgery -- Subject index. DVD: 1. Transition to bimanual phaco -- 2. Bimanual vertical chop technique #1 -- 3. Bimanual vertical chop technique #2 -- 4. VST torn capsule -- 5. Bimanual post PKP post RK -- 6. Spinoffs of bimanual technology.
    Also available: Print – 2005
  • 2008 ClinicalKey
    edited by F. Hampton Roy.
    1. Bausch & Lomb 217z100 excimer laser platform / Sheraz M. Daya and Marcela Espinosa-Lagana -- 2. Custom LASIK and PRK with the Visx Star Laser / Michael J. Taravella, Richard S. Davidson and Scott A. Thomas -- 3. The LadarVision system / Ronald R. Krueger -- 4. WaveLight Allegretto / Simon Holland and C. David Lin -- 5. Nidek Navex / Mihai Pop and Harkaran S. Bains -- Schwind ESIRIS excimer laser / Diego de Ortueta, Thomas Magnago and Jens Flügge -- 7. Optimized and wavefront-guided corneal refractive surgery using the Carl Zeiss Meditec platform: CRS-Master and MEL 80 excimer laser / Daniel Z. Reinstein et al. -- 8. Multifocal cornea / Gustavo E. Tamayo -- 9. Katana LaserSoft: a solid-state laser for refractive surgery / Matteo Piovella, Fabrizio I. Camesasca and Barbara Kusa -- 10. CustomVis Pulzar Z1 / Tarak Pujara -- 11. Refractive lens exchange / Mark Packer, I. Howard Fine, Richard S. Hoffman and H. Burkhard Dick -- 12. Surgical reversal of presbyopia / Gene W. Zdenek and Jack C. Griffis.
  • 2014 Springer
    Aniyizhai Annamalai, editor.
    "Physicians receive very little training in refugee health. Refugee Health Care is a practical guide providing concise information for busy practitioners. This concise textbook reviews common conditions seen in refugees and some of the recommendations in the book apply to all immigrants. It will be a valuable resource for primary care physicians, psychiatrists, pediatricians, women's health providers and any health care practitioner who treats refugees."--Publisher's website.
  • 2011 Springer
    Ira S. Cohen, Glenn R. Gaudette, editors.
    Inducing embryonic stem cells to become cardiomyocytes / Alexander M. Becker, Michael Rubart, and Loren J. Field -- Regenerating function in vivo with myocytes derived from embryonic stem cells / Priya R. Baraniak and Todd C. McDevitt -- Excitation-contraction coupling, functional properties, and autonomic and hormonal regulation in human embryonic stem cell derived cardiomyocytes / Oshra Sedan and Ofer Binah -- Embryonic stem cell derivatives for cardiac therapy : advantages, limitations, and long-term prospects / Michal Weiler-Sagie and Lior Gepstein -- Methods for differentiation of bone-marrow-derived stem cells into myocytes / Shinji Makino and Keiichi Fukuda -- Homing, survival, and paracrine effects of human mesenchymal stem cells / Sergey Doronin -- Bone marrow cell therapy after myocardial infarction : what have we learned from the clinical trials and where are we going? / Kai C. Wollert -- Evidence for the existence of resident cardiac stem cells / Isotta Chimenti ... [et al.] -- Multiple sources for cardiac stem cells and their cardiogenic potential / Antonio Paolo Beltrami, Daniela Cesselli, and Carlo Alberto Beltrami -- Skeletal muscle stem cells in the spotlight : the satellite cell / Zipora Yablonka-Reuveni and Kenneth Day -- Regenerating mechanical function in vivo with skeletal myoblasts / Todd K. Rosengart and Muath Bishawi -- Methods for inducing pluripotency / Raymond L. Page, Christopher Malcuit, and Tanja Dominko -- Inducible pluripotent stem cells for cardiac regeneration / Naama Zeevi-Levin and Joseph Itskovitz-Eldor -- Induced pluripotent cells for myocardial infarction repair / Timothy J. Nelson and Andre Terzic -- Substrates of cardiac reentrant arrhythmias : the possible role of tissue regeneration and replacement / André G. Kléber -- Integration of stem cells into the cardiac syncytium : formation of gap junctions / Peter R. Brink, Ira S. Cohen, and Richard T. Mathias -- Bradyarrhythmia therapies : the creation of biological pacemakers and restoring atrioventricular node function / Richard B. Robinson -- Tachyarrhythmia therapies : approaches to atrial fibrillation and postinfarction ventricular arrhythmias / J. Kevin Donahue and Kenneth R. Laurita -- Long-term prospects for arrhythmia treatment : advantages and limitations of gene and cell therapies / Michael R. Rosen -- Regenerating blood vessels / Tracy A. Gwyther and Marsha W. Rolle -- Regenerating heart valves / Benedikt Weber and Simon P. Hoerstrup -- Tissue engineering strategies for cardiac regeneration / Amandine F.G. Godier-Furnémont ... [et al.] -- Methods of cell delivery for cardiac repair / Sarah Fernandes and Hans Reinecke -- Tracking of stem cells in vivo / Yingli Fu and Dara L. Kraitchman -- Assessing regional mechanical function after stem cell delivery / Jacques P. Guyette and Glenn R. Gaudette.
  • 2005 Springer
    A. Keating ... [et al.], editors.
  • 2012 ScienceDirect
    David L. Stocum.
  • 2006 ScienceDirect
    David L. Stocum.
  • 2012 Springer
    edited by Rahul Jandial, Mike Y. Chen ; associate editors, Bihong T. Chen, Joseph Ciacci.
    Frontiers of spinal cord and spine repair : experimental approaches for repair of spinal cord injury / Choya Yoon and Mark H. Tuszynski -- Stem cell based strategies for spinal cord injury repair / Alexa Reeves and Hans S. Keirstead -- Strategies for endogenous spinal cord repair : HPMA hydrogel to recruit migrating endogenous stem cells / Araceli Espinosa-Jeffrey ... [et al.] -- Stem cells and spinal cord injury repair / Soheila Karimi-Abdolrezaee and Eftekhar Eftekharpour -- Chronic pain following spinal cord injury / Radi Masri and Asaf Keller -- Repair of radiation damage and radiation injury to the spinal cord / Timothy E. Schultheiss -- Malignancies of the spinal cord / J. Dawn Waters, Encarnacion Maria Navarro Peran, and Joseph Ciacci -- Molecular basis of intervertebral disc degeneration / Dipika Gopal ... [et al.] -- Bioceramics for osteogenesis, molecular and cellular advances / Hande Demirkiran -- Cell-based therapies for spinal fusion / Ronke Olabisi -- Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering / Josh Neman ... [et al.] -- Progenitor cells : role and usage in bone tissue engineering approaches for spinal fusion / Lonnissa H. Nguyen ... [et al.].
    Also available: Print – 2012
  • 2011 Springer
    Gustav Steinhoff, editor.
  • 2015 Springer
    Niranjan Bhattacharya, Phillip George Stubblefield, editors.
    This book represents a major contribution to the emerging science of regenerative medicine using non-fetal sources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have brought together some of the most pre-eminent scientists working on regenerative medicine to share information on currently ongoing work in this area alongside unpublished observations that will help to shape the contours of future therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem Cells discusses the potential clinical and therapeutic applications using non-fetal stem cells as well as providing instruction on the collection, isolation and characterization of stem cells from various non-fetal sources, such as menstrual blood, adipose tissue, breast milk and uprooted decidual teeth. This book will be an invaluable resource for both active researchers and those entering the field. The Editors truly hope that the text will act as a stimulant to professionals and clinical scientists, who may be inspired to further the work of the pioneering scientists who have contributed to this volume.
  • 2013 Springer
    Hossein Baharvand, Nasser Aghdami, editors.
    1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
  • 2014 ScienceDirect
    [edited by] Giuseppe Orlando, Jan Lerut, Shay Soker, Robert J. Stratta.
    Principles of regenerative medicine and cell,tissue and organ bioengineering -- Kidney -- Liver -- Heart -- Small bowel -- Endocrine pancreas and islets of langerhans -- Lung -- Composite tissues allotranplantation -- Immunosuppression-free transplantation in the regenerative medicine era.
  • 2014 Springer
    Linda F. Hogle, editor.
    Regenerative medicine is at a pivotal point. Innovations in the science and the rapid growth of translational medicine are transforming the field just as institutional arrangements are changing, making this an exciting yet unsettled time. Recent court cases and policy initiatives are creating crosscurrents that keep older issues from being settled while introducing new dilemmas. Current research propels collaborations across disciplines and sectors, raising the question of how tensions between the protection of intellectual property and the movement toward "open science" can be negotiated. Other important social, ethical and legal questions arise in the gray areas created by new scientific techniques and pragmatic areas involved in scale-up and testing in humans. The times call for governance that is adaptive to meet the needs of science yet able to maintain public trust. The contributors address these and other vital questions through chapters focusing on topics such as data sharing; patenting of human biological material; and managing collaborations across academic, industry and government sectors as well as across national boundaries. Key research ethics issues are also included such as obtaining consent from biospecimen donors; accessing biorepository data, and considerations in designing preclinical and clinical trial protocols for first-in-human research, including upcoming policy changes. Rather than retracing well-trodden topics, the book points to nascent areas that need to be addressed. Whether working in academia, industry, or government, regenerative medicine scientists and managers need to know how to navigate current and upcoming issues of governance facing the field. Regenerative Medicine Ethics: Governing Research and Knowledge. Practices will be a valuable resource for scientists, policy-makers and students as they plan and execute responsible research.
  • 2014 Springer
    Juichi Ito, editor.
    The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
  • 2015 Springer
    Juichi Ito, editor.
    Preface -- Part 1: Current siguation of the regenerative medicine -- Chapter 1: Current siguation of the regenerative medicine -- Part 2: Development and regeneration of the ear.- Chapter 2: The innner ear -- Chapter 3: Regeneration of the Soft Tissue Defects of the External Auditory Meatus -- Chapter 4: Regeneration of the Tympanic Membrane -- Chapter 5: An approach in regenerative medicine for the treatment of intractable otitis media -- Chapter 6: Peripheral Nerve Regeneration by Tissue Engineering for Prevention of Misdirection -- Part 3: Development and regeneration of the nose and the paranasal sinuses -- Chapter 7: Development and regeneration of the nose and the paranasal sinuses -- Part 4: Development and regeneration of the oral cavity and the pharynx -- Chapter 8: Development and regeneration of the oral cavity and the pharynx -- Part 5: Development and regeneration of the larynx -- Chapter 9: Laryngeal Development -- Chapter 10: Laryngeal framework regeneration -- Chapter 11: Vocal folds Development -- Chapter 12: Regeneration of the vocal fold -- Part 6: Development and regeneration of the head & neck -- Chapter 13: Cranial bone regeneration -- Chapter 14: Salivary gland development and regeneration -- Chapter 15: Regeneration of the Trachea -- Chapter16: Future perspective.
  • 2011 Springer
    Niranjan Bhattacharya, Phillip Stubblefield (editors).
    A massive wastage of the global resources -- Placenta as a source of stem cells and as a key organ for fetomaternal tolerance -- Placenta and umbilical cord in traditional Chinese medicine -- Use of umbilical venous blood on assessing the biochemical variations of acid-base, nutritional and metabolic parameters on growth-retarded fetuses, in comparison with gestational control cases: a study -- Umbilical cord blood transfusion and its therapeutic potentialities -- Autologous placental blood transfusion for the therapy of anemic neonates -- Cord blood: a massive waste of a life-saving resource: a perspective on its current and potential uses -- Clinical experience of cord blood autologous transfusion -- Emergency use of human cord blood -- Hemoglobin-based oxygen carriers in trauma care: the US multicenter prehospital trial -- Placental umbilical cord blood as a true blood substitute with an edge -- Implications of feto-maternal cell transfer in normal pregnancy -- Early reports on the prognostic implications and immunotherapeutic potentials of Cd34 rich cord whole blood transfusion in advanced breast cancer with severe anemia -- Anti-inflammatory effects of human cord blood and its potential implications in neurological disorders -- Transforming "waste" into gold: identification of novel stem cells resources with therapeutic potential in neuromuscular disorders -- Human umbilical cord blood cells for stroke -- Placental umbilical cord blood transfusion for stem cell therapy in neurological diseases -- Umbilical cord and its blood: a perspective on its current and potential use in ophthalmology -- Umbilical vein grafts for lower limb revascularization -- Cord blood stem cells in angiogenesis. Endothelial progenitor cells from cord blood: magic bullets against ischemia? -- Therapeutic potential of placental umbilical cord blood in cardiology -- Stem cell therapy for heart failure using cord blood -- Human umbilical cord blood mononuclear cells in the treatment of acute myocardial infarction -- Umbilical cord-derived mesenchymal stem cells -- Cord blood stem cell expansion ex vivo: current status and future strategies -- Embryonic-like stem cells and the importance of human umbilical cord blood for regenerative medicine -- Use of non-hematopoietic stem cells of fetal origin from cord blood, umbilical cord, and placenta in regeneration medicine -- Animal studies of cord blood and regeneration -- Immune privilege of cord blood -- Combination cellular therapy for regenerative medicine: the stem cell niche -- Use of cord blood in regenerative medicine -- Comparisons between related and unrelated cord blood collection and/or banking for transplantation or research: the UK NHS blood and transplant experience -- Donor and collection-related variables affecting product quality in ex utero cord blood banking -- Cord blood as a source of hematopoietic progenitors for transplantation -- Amniotic fluid and placenta stem cells -- Use of amniotic membrane, amniotic fluid, and placental dressing in advanced burn patients -- Clinical use of amniotic fluid in osteoarthritis: a source of cell therapy -- A study and follow-up (1999-2009) of human fetal neuronal tissue transplants at a heterotopic site outside the brain in cases of advanced idiopathic Parkinsonism -- Ethical issues surrounding umbilical cord blood donation and banking.
  • 2011 ScienceDirect
    2011 ClinicalKey
    edited by Michael S. Goligorsky.
    Chapter 1. Glomerulogenesis and De Novo Nephrogenesis in Medaka Fish: An Evolutionary Approach / Hisashi Hashimoto, Yuko Wakamatsu -- Chapter 2. Renal Organogenesis: Growing a Replacement Kidney In Situ from Transplanted Renal Primordia / Marc R. Hammerman -- Chapter 3. Use of Genetic Mouse Models to Study Kidney Regeneration / Akio Kobayashi, Jeremy S. Duffield -- Chapter 4. Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease / Charles N. Serhan, Catherine Godson -- Chapter 5. Tissue Protection and Regeneration Aided by Erythropoietin and Erythropoietin-derived Peptides / Danilo Fliser -- Chapter 6. Mast Cells in Kidney Regeneration / Eric Daugas, Walid Beghdadi, Ulrich Blank -- Chapter 7. Role of Macrophages in Renal Injury, Repair and Regeneration / Vincent Lee, Qi Cao, Yiping Wang, David C.H. Harris -- Chapter 8. T-cell Contribution to Injury and Regenerative Processes in Kidney Diseases: Focus on Regulatory T Cells / Hye Ryoun Jang, Hamid Rabb -- Chapter 9. Mesenchymal Stem Cells / Benjamin D. Humphreys, Joseph V. Bonventre -- Chapter 10. Endothelial Progenitor Cells and the Kidney / Matthieu Monge, Anton Jan van Zonneveld, Ton J. Rabelink -- Chapter 11. Potential of the Side Population in Regenerative Nephrology / M.H. Little, G.A. Challen -- Chapter 12. Very Small Embryonic-like Stem Cells and Their Potential Relevance for Kidney Homeostasis / Dong-Myung Shin, Rui Liu, Przemyslaw Nowacki, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak -- Chapter 13. Induced Pluripotent Stem Cells / Kenji Osafune, Shinya Yamanaka -- Chapter 14. Methods of Isolation and Culture of Adult Stem Cells / Lindolfo da Silva Meirelles, Nance Beyer Nardi -- Chapter 15. Stem Cell Niche in the Kidney / Laura Lasagni, Elena Lazzeri, Paola Romagnani -- Chapter 16. Bioartificial Stem Cell Niches: Engineering a Regenerative Microenvironment / Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff, Michael S. Goligorsky -- Chapter 17. Imaging of Transplanted and Native Stem Cells / Xiang-Yang Zhu, Martin Rodriguez-Porcel, Lilach O. Lerman -- Chapter 18. Stem Cell Injury and Premature Senescence / Michael S. Goligorsky -- Chapter 19. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway / Nica M. Borradaile, Alanna Watson, J. Geoffrey Pickering -- Chapter 20. Bone Marrow Mesenchymal Stem Cells in Organ Repair and Strategies to Optimize their Efficacy / Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi, Marina Morigi -- Chapter 21. Treatment of Acute Kidney Injury with Allogeneic Mesenchymal Stem Cells: Preclinical and Initial Clinical Data / Florian E. Tögel, Christof Westenfelder -- Chapter 22. Clinical Trials in Renal Regenerative Medicine / Maarten B. Rookmaaker, Jaap A. Joles, Marianne C. Verhaar -- Chapter 23. Potential Risks of Stem Cell Therapies / Uta Kunter, Jürgen Floege -- Chapter 24. Tissue Engineering in Urology / Anthony Atala -- Chapter 25. Ethics in Regenerative Medicine / Svetlana Gavrilov, Donald W. Landry -- Chapter 26. Stem Cell Banking / Vicente Mirabet, Pilar Solves.
  • 2013 Cambridge
    edited by George J. Christ, Karl-Erik Andersson.
    "Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research"--Provided by publisher.
  • 2012 Springer
    David S. Allan, Dirk Strunk, editors.
  • 2012
    George Church & Ed Regis.
    Status: Not Checked OutLane Catalog Record
    From bioplastics to H. sapiens 2.0 -- -3,800 Myr, Late Hadean : at the inorganic/organic interface -- -3,500 Myr, Archean : reading the most ancient texts and the future of living software -- -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be? -- -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum" -- -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering -- -30,000 Yr, Pleistocene Park : engineering extinct genomes -- -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto -- -100 Yr, Anthropocene : the third industrial revolution ; iGEM -- -1 Yr, Holocene : from personal genomes to immortal human components -- Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
  • edited by Paul Kopperman.
    In 1746, Dr. John Buchanan, a recently retired medical officer in the British Army, produced a manuscript, 'Regimental Practice, or a Short History of Diseases common to His Majesties own Royal Regiment of Horse Guards when abroad (Commonly called the Blews).' Revised almost until the time of Buchananan's death in 1767, it was primarily based on the author's observations while surgeon to a cavalry regiment serving in Flanders 1742-1745 during the War of the Austrian Succession. It is presented here as an annotated modern edition of the text.
  • v. 2, 1945-.
    by Charles V. Morrill ...
    Status: Not Checked OutLane Catalog Record
    [v. 1] The upper extremity -- [v. 2] The neck and head -- [v. 3] The abdomen and pelvis -- [v. 4] The thorax and back.
  • v. 1-2, 1955-59.
    Taylor, John Alexander.
    Status: Not Checked OutLane Catalog Record
    pt. 1. Head and neck -- pt. 2. Thoracic limb -- pt. 3. Pelvic limb -- pt. 4. Thorax and abdomen.
  • 2012 Cambridge
    Jeff Gadsden.
    1. Principles of pain management in trauma care -- 2. Acute pain, regional anesthesia and the stress response -- 3. The progression from acute to chronic pain -- 4. Prehospital regional anesthesia -- 5. Regional anesthesia and digital replantation -- 6. Regional anesthesia and compartment syndrome -- 7. Regional anesthesia for blunt chest trauma -- 8. Regional anesthesia, trauma, and complex regional pain syndrome -- 9. Regional anesthesia and combat care -- 10. Regional anesthesia for pediatric trauma -- 11. Regional anesthesia for fractured neck of femur -- 12. Regional anesthesia in the intoxicated trauma patient -- 13. Regional anesthesia for humeral shaft fracture -- 14. Regional anesthesia for burns -- 15. Regional anesthesia, penetrating abdominal trauma and sepsis -- 16. Regional anesthesia in the injured obese patient -- 17. Regional anesthesia and lower extremity trauma -- 18. Regional anesthesia and traumatic limb amputation -- 19. Complications of brachial plexus blockade -- 20. Regional anesthesia and trauma in pregnancy -- 21. Regional anesthesia and the injured athlete.
  • 2007 Springer
    edited by Peter M. Schlag, Ulrike Stein ; foreword by Alexander M.M. Eggermont.
  • 2015 Springer
    Danilo Jankovic, Philip Peng.
    General Considerations -- Head and Neck Region -- Cervical Region -- Shoulder -- Upper extremity -- Elbow and Wrist -- Thoracic Region -- Lumbosacral spine -- Abdominal and Pelvic region -- Lower extremity block -- Lower extremity musculoskeletal injection -- Regional block for children.
  • 2011
    David Yoonsuk Oh.
    T cell development involves stereotyped movements of developing thymocytes through specific stromal microenvironments in thymus, with immature double-negative (DN, CD4-CD8-) and double-positive (DP, CD4+CD8+) thymocytes found in cortex, and mature single-positive (SP, CD4+CD8- or CD4-CD8+) thymocytes in medulla. Critical events occur in each of these locations, notably positive selection, which leads to survival and maturation of DPs and occurs in cortex, and negative selection, which leads to elimination of autoreactive thymocytes and can occur in cortex or medulla depending on the type of antigen. Several key questions remain about the mechanisms underlying these developmental transitions. How are thymocytes properly localized to cortex and medulla? Is there further specialization of stroma within these regions for supporting thymocyte migration or signaling? How do Ca2+ signals, which are critical for both positive and negative selection, differ between these two developmental pathways? In this thesis, we utilize thymic slices, which preserve native stromal architecture and support thymocyte development, to address these questions. Two-photon microscopy of fluorescently labeled thymocytes within slices allows us to non-invasively image the migration, localization, and signaling of single thymocytes in real time, providing a better understanding of how these behaviors are regulated during development and also as a function of location in tissue. In Chapter 2, we address the question of how developing thymocytes are localized to their proper tissue locations in thymus. When layered on the cut surface of slices, purified stages of thymocytes localize to their proper thymic environments, with immature DNs and DPs restricted to cortex, and SPs concentrating in medulla. Remarkably, we find evidence for two distinct mechanisms controlling proper localization of immature versus mature thymocytes. Pre-selection DPs are strictly localized to cortex by their inability to migrate on medullary substrates. SPs localize to medulla via CCR7-dependent chemotaxis, which is directly demonstrated, as well as a novel GPCR-mediated signaling module permitting SP migration on medullary substrates. In Chapter 3, we examine differences in Ca2+ signaling between positive versus negative selection, as well as between distinct locations in thymus, and clarify the role of Ca2+ in controlling motility during negative selection. We find larger Ca2+ signals during early stages of negative selection relative to positive selection, and stronger signaling in response to selecting antigens in the inner cortex near medulla. Sustained Ca2+ signals during negative selection are largely not required for stopping cells, but do contribute to prolonging motile arrest of a proportion of the thymocyte population. Overall these results point to several key events during the transition from cortical DPs to medullary SPs that may enhance the efficiency of selection. As DPs pass through a specialized inner cortical environment, they may become more responsive to peptide ligands leading to positive and negative selection. Stronger Ca2+ signals during negative compared to positive selection in DPs and SPs may help to commit thymocytes to death over maturation. Finally, the ability to migrate in medulla, which thymocytes acquire post-positive selection, may represent an important developmental switch confining pre-selection cells to cortex for further testing against selecting antigens, while permitting post-positive selection thymocytes to undergo an additional layer of testing against tissue-specific antigens, followed by maturation and exit.
  • 2015
    transcribed by T. Bradford Willis, DDS, MSD.
  • 2014 Springer
    by Alexander Schmidt-Richberg.
    Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.
  • 2014
    prepared for Agency for Healthcare Research and Quality, U.S. Department of Health and Human Services ; prepared by Outcome Sciences, Inc., ; senior editors, Richard E. Gliklich, Nancy A. Dryer ; editor, Michelle B. Leavy.
    This User's Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure.
  • Google Books
    Also available: Print – 1964-
  • 2005 Springer
    Eric Vittinghoff ... [et al.].
    Introduction -- Exploratory and descriptive methods -- Basic statistical methods -- Linear regression -- Predictor selection -- Logistic regression -- Survival analysis -- Repeated measures analysis -- Generalized linear models -- Complex surveys -- Summary.
  • 2009 CRCnetBASE
    Michael Panik.
    Review of fundamental of statistics -- Bivariate linear regression and correlation -- Misspecified disturbance terms -- Nonparametric regression -- Logistic regression -- Bayesian regression -- Robust regression -- Fuzzy regression -- Random coefficients regression -- L1 and q-Quantile regression -- Regression in a spatial domain -- Multiple regression -- Normal correlation models -- Ridge regression -- Indicator variables -- Polynomial model estimation -- Semiparametric regression -- Nonlinear regression -- Issues in time series modeling and estimation.
  • 2011
    Manuel Eduardo Lopez, Jr.
    Niemann-Pick disease type C (NPC) is a rare metabolic lysosomal storage disorder (LSD) marked by accumulation of large quantities of cholesterol, lipids and other metabolites in cells. Though the disorder has been extensively explored using various genetic animal models, an understanding of the molecular and cellular pathology of the disease remains limited. A cell-type-specific and regulable rescue mouse model of NPC disease was engineered in order to identify the therapeutically relevant cell type and ascertain the effect of inflammation on disease progression. With the current information presented in this dissertation, a probable road map of NPC disease pathology has been drawn. The road map for NPC may also be applicable to, or act as a template for, other lysosomal storage diseases and neurodegenerative disorders with similar pathologies.
  • 2014 ScienceDirect
    edited by Avi Ashkenazi, Junying Yuan and James A. Wells.
    Examining the molecular mechanism of Bcl-2 family proteins at membranes by fluorescence spectroscopy -- Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry -- The structural biology of BH3-only proteins -- How to analyze mitochondrial morphology in healthy cells and apoptotic cells in Caenorhabditis elegans -- Apoptosis initiation through the cell-extrinsic pathway -- Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway -- Caspase enzymology and activation mechanisms -- Turning on caspases with genetics and small molecules -- A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases -- Measuring caspase activity in vivo -- Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology -- In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe -- Global analysis of cullular proteolysis by selective enzymatic labelling of protein N-termini -- Complementary methods for the indentification of substrates of proteolysis -- Phospholipid scrambling on the plasma membrane -- Studying apoptosis in the zebrafish.
  • 2014 ScienceDirect
    edited by Avi Ashkenazi, James A. Wells and Junying Yuan.
  • 2013 Springer
    David A. Dougan, editor.
    AAA+ proteolytic machines -- Machines of destruction: AAA+ proteases and the adaptors that control them / Eyal Gur, Ralf Ottofueling, David A. Dougan -- The Lon AAA+ protease / Eyal Gur -- FtsH protease-mediated regulation of various cellular functions / Takashi Okuno, Teru Ogura -- Regulatory proteolysis in bacteria -- General and regulatory proteolysis in Bacillus subtilis / Nöel Molière, Kürşad Turgay -- Proteolytic regulation of stress response pathways in Escherichia coli / Dimce Micevski, David A. Dougan -- Regulated proteolysis: control of the Escherichia coli [sigma]E-dependent cell envelope stress response / Sarah E. Barchinger, Sarah E. Ades -- Bacterial proteases and virulence / Dorte Frees, Lone Brøndsted, Hanne Ingmer -- Regulated proteolysis in yeast -- Roles of Cdc48 in regulated protein degradation in yeast / Alexander Buchberger -- The Role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control / Wolfgang Voos, Linda A. Ward, Kaye N. Truscott -- Ubiquitin-like protein modification and protein degradation in microorganisms -- The pup-proteasome system of mycobacterium tuberculosis / Marie I. Samanovic, Huilin Li, K. Heran Darwin -- Archaeal proteasomes and sampylation / Julie A. Maupin-Furlow.
  • 2012
    Weibin Zhang.
    For successful segregation of chromosomes during meiosis, chromosomes have to recognize and align with their correct homologous partners, and then stabilize the homologous alignment with assembly of a proteinaceous structure, called the synaptonemal complex (SC), between them. SC assembly is highly processive and cooperative, yet the SC structure does not distinguish between homologous and nonhomologous associations. Thus SC assembly has to be tightly regulated and coordinated with homologous pairing to ensure that the SC is stabilizing productive homologous associations. Moreover, homologous pairing is accompanied by dramatic chromosome movement and nuclear reorganization of chromosomes into a clustered configuration during C. elegans early meiotic prophase. Subsequently, the clustered chromosomes are redispersed into aligned homologs upon SC assembly. The exact mechanisms involved in regulation and coordination of homologous pairing and synapsis are poorly understood, and this thesis was aimed at gaining a better understanding of the coordination of these two inter-related meiotic events. We identified HAL-2 as a major player in this coordination. We demonstrated that HAL-2 promotes homologous pairing mainly by preventing detrimental effects of SC precursors (SYP proteins). Homologous pairing is not established in hal-2 mutants, and several markers indicative of pairing center-mediated chromosome movement are also absent in hal-2 mutants. Pairing centers (PCs) are cis-acting chromosomal sites that mediate chromosome movement by connecting chromosomes to cytoplasmic microtubules via the conserved SUN-1/ZYG-12 nuclear envelope-spanning complexes. hal-2 mutants also exhibit defective SC assembly, with SYP proteins being loaded inappropriately along single unpaired chromosomes in hal-2 mutants. Moreover markers of PC-mediated chromosome movement and function are coordinately restored in hal-2 mutants by the removal of SYP proteins. Combined with other data, these findings indicate that SYP proteins can inhibit homologous pairing and that HAL-2 promotes pairing largely by antagonizing this inhibition, thus allowing activation and regulation of PC function. Given that HAL-2 concentrates in the nucleoplasm of meiotic germ cells and colocalizes with SYP proteins in nuclear aggregates when SC assembly is prevented, we propose that HAL-2 functions to shepherd SYP proteins prior to licensing of SC assembly, preventing SC precursors from interacting inappropriately with chromosomes and allowing them to accumulate sufficiently for rapid cooperative assembly upon homology verification. In this thesis, we also identified and characterized me16, a hypomorphic allele of scc-3. SCC-3 is a conserved component of the cohesin complex, and the scc-3(me16) mutant was demonstrated to be a partial loss of function mutation by comparative analyses with a null mutant, scc-3(ku263). Besides reduced chromosomal localization of cohesin, scc-3(me16) mutants also display an extended region of clustered chromosomes, incomplete SC assembly and defective recombination. Further, analyses of nuclear aggregates that form in the scc-3(ku263) null mutants led to the findings that components of the lateral elements, including cohesin, colocalize into these nuclear aggregates and that this localization is not dependent on REC-8.
  • 2010
    Sandy Agathe van Gool.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Andrea Elise Hartsock.
    Throughout development cells must go through numerous changes in cell-cell adhesiveness. Within an epithelial layer, cell-cell contacts form and maintenance junctional complexes such as Adherens Junctions, Tight Junctions, and Desmosomes. The Adherens junction (AJ) and Tight junction (TJ) provide important adhesive contacts between neighboring epithelial cells. Although these junctions comprise different proteins, there are similarities in the roles of specialized transmembrane proteins in forming extracellular adhesive contacts between cells, and intracellular links to the actin cytoskeleton and signaling pathways including the regulation of gene transcription. The Adherens junction performs multiple functions including initiation and stabilization of cell--cell adhesion, regulation of the actin cytoskeleton, intracellular signaling and transcriptional regulation. The core of the Adherens junction includes interactions among transmembrane glycoproteins of the classical cadherin superfamily, such as E-cadherin, and the catenin family members including p120-catenin, [Beta]-catenin, and [Alpha]-catenin. Together, these proteins control the formation, maintenance and function of adherens junctions. Tight junctions have been proposed to have two mutually exclusive functions: a fence function which prevents the mixing of membrane proteins between the apical and basolateral membranes; and a gate function which controls the paracellular passage of ions and solutes in-between cells. Tight junctions contain two types of transmembrane proteins, occludins and claudins, which confer these functions, and associated cytoplasmic proteins that may link tight junctions to the actin-cytoskeleton and the adherens junction. Adherens Junction mediated cell--cell adhesion is highly dynamic enabling the reorganization and dispersal of cells, for example, during epithelial-to-mesenchymal transition in normal development and carcinogenesis. p120-Catenin binding to, and Hakai (an E3 ubiquitin ligase)-mediated ubiquitination of the juxtamembrane domain (JMD) of E-cadherin are thought to be involved in regulating E-cadherin internalization and degradation. However, the relationship between these two pathways is not known. The aim of my project was to determine if p120-catenin/E-cadherin and Hakai dependent ubiquitination of E-cadherin are mechanistically linked. We targeted the E-cadherin JMD to mitochondria (WT-JMD) to isolate this domain from the plasma membrane and internalization, and to examine protein modifications and degradation. WT-JMD was targeted to mitochondria, but it did not accumulate there except when proteasome activity was inhibited. We found that WT-JMD was ubiquitinated, and arginine substitution of lysines at position 5 (K5R) and 83 (K83R) resulted in the stable accumulation of mutant JMD at mitochondria. p120-Catenin did not localize, or bind to WT-JMD even upon proteasome inhibition, whereas the K5,83R JMD mutant bound p120-catenin and localized it to mitochondria. Mutation of the p120-catenin binding site in combination with these lysine mutations inhibited p120-catenin bind-ing, but did not decrease JMD stability or its accumulation at mitochondria. Further-more, over-expression of Hakai resulted in inhibition of p120-catenin binding to WT-JMD. Thus, increased stability of JMD lysine mutants was due to inhibition of ubiquitination and not to p120-catenin binding. Finally, mutation of these critical lysines in full length E-cadherin had the same effects on protein stability as mitochondria-targeted E-cadherin JMD. Our results indicate that ubiquitination of the JMD inhibits p120-catenin binding, and targets E-cadherin for degradation via the proteasome. Further work needs to be done to test our hypothesis that p120-catenin stabilizes E-cadherin by masking ubiquitination sites within E-cadherin-JMD.
  • 2009
    Hector Y. Caro-Gonzalez.
    Status: Not Checked OutLane Catalog Record
  • 2012
    Jose Rafael Morillo Prado.
    Many adult tissues with short-lived cells such as blood and skin require a constant replacement of aging cells. This process is often accomplished by adult stem cells, both self-renew and give rise to differentiating progeny. The process of self-renewal and differentiation must be tightly controlled: failure to self-renew results in the loss of the stem cell population, and lack of differentiation impairs tissue function with dire consequences to the organism. The fate decisions of stem cells are guided by the interaction between extracellular signals from the local microenvironment and intrinsic factors that set the state of the cell, many of which are coordinated by transcriptional programs that are, in turn, is controlled by posttranslational modifications of histones or replacement of canonical histones with histone variants. Polycomb group (PcG) proteins partake in the modification of histones and influence the transcriptional state of genes. PcG proteins are involved in transcriptional regulation by inducing the methylation and ubiquitination of histone tails, which maintain the repression of target genes through cell divisions. Emerging evidence indicates that replacement of canonical histones with histone variants is also important in cell fate decisions. Here I show that PcG proteins Psc and Su(z)2 restrict proliferation and maintain the identity of the cyst stem cell (CySC) lineage in the Drosophila testis. Loss of Psc and Su(z)2 gene function in CySC but not in the germline stem cell (GSC) lineage resulted in the formation of a tumor composed of proliferative mutant cells of abnormal identity, likely due to the derepression of the Hox gene Abdominal-B. The resulting formation of tumor-like masses of proliferative cells interfered non-cell autonomously with maintenance of the germline most likely by displacing GSCs from their niche. I also show that the histone variant His2Av is required cell-autonomously for maintenance of adult stem cells in both somatic and germ cell lineages. GSCs lacking His2Av function were lost over time. Surprisingly, GSCs null mutant for His2Av gave rise to germ cells that underwent normal transit amplification divisions and differentiation to spermatocytes and spermatids. Similarly, CySCs lacking His2Av were also lost over time, but were able to give rise to differentiated cyst cells. My results indicate that His2Av and Stat92E likely maintain GSCs and CySCs independently. His2Av mutant GSCs expressed Stat92E and had properly oriented centrosomes, while Stat92E mutant GSCs expressed His2Av. My results expand knowledge chromatin states required for adult stem cell function, showing, for the first time, that a histone variant has a unique role in maintaining stem cells.
  • 2012
    Alicia Roberta Shields.
    Adult stem cells generate short-lived but highly differentiated cells that maintain and repair tissues which exhibit high turnover rates or tissues prone to wear and tear including sperm, skin, blood, intestinal epithelium and muscle. Adult stem cells typically reside in specialized microenvironments or stem cell niches, and a major goal of stem cell biology is to understand how these specialized microenvironments regulate adult stem cell self-renewal, proliferation and differentiation to maintain tissue homeostasis. Drosophila spermatogenesis provides an in vivo model system to investigate how the niche governs adult stem cell behavior. At the apical tip of the Drosophila testis, a cluster of post-mitotic support cells called the hub maintains two adult stem cell populations, germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Hub cells secrete the Unpaired ligand, which activates JAK-STAT signaling in the neighboring GSCs and CySCs. JAK-STAT signaling and coordinated crosstalk between the germ line and soma together maintain GSCs and CySCs within the stem cell niche and direct proper association between their differentiating daughter cells. In this dissertation, I address two questions: (1) how a putative gene target of JAK-STAT influences stem cell self-renewal and maintenance and (2) how a transcriptional co-activator controls stem cell differentiation. To investigate the mechanism by which JAK-STAT signaling regulates GSC maintenance, I probed the function of profilin, a regulator of filamentous actin (F-actin). Profilin had been identified as a STAT target gene in the testis stem cell niche by performing chromatin immunoprecipitation with antibodies against phosphorylated STAT (activated STAT), followed by high throughput sequencing (ChIP-Seq) (Davies et al., submitted). It was already known that profilin mutants lose early germ cells (Gönczy and DiNardo, 1996) but the germline stem cell phenotype had not been characterized. I showed that GSCs were lost throughout development with markedly reduced GSC numbers in testes from late third instar larval hypomorphs and strong loss-of-function profilin mutants. By performing clonal analysis with null profilin alleles, I found that wild-type function of profilin was required cell autonomously for GSC maintenance. GSCs homozygous mutant for profilin detached from the hub and differentiated. F-actin and Adenomatous Polyposis Coli 2 (APC2) localization at the hub-GSC interface was disrupted in testes from profilin mutants. Interestingly, germline specific over-expression of APC2 rescued GSC loss in profilin hypomorphs. My studies suggested that profilin may be indirectly required to stabilize APC2 and [beta]-catenin at E-cadherin-based adherens junctions between hub cells and GSCs. Intercellular conversations between the germ line and the soma regulate the behavior of the stem cells in both lineages. I showed that a mutation in the MED20 gene, which encodes one of the subunits of Mediator, a multiprotein complex that acts as an interface between gene-specific regulatory proteins and the general transcriptional machinery to stimulate transcription, resulted in over-proliferation of both germline stem cells (GSCs) and somatic cyst stem cells (CySCs). Mediator function was required cell autonomously for CySCs to differentiate into somatic cyst cells, and non-autonomously for germ cell differentiation. This study reinforced the importance of crosstalk between stem cell lineages that work together to maintain tissue homeostasis.
  • 2016 Springer
    edited by Sajal Chakraborti, Naranjan S. Dhalla.
  • 2006 Springer
    edited by A-Majid Khatib.
  • 2010
    Craig Betts.
    The centromere is a specialized chromatin domain that is required for kinetochore formation and chromosomal attachment to the mitotic spindle. In higher eukaryotes, centromere identity is independent of the underlying DNA sequence and is thought to be propagated through epigenetic mechanisms. One of the defining features of centromeric chromatin is the presence of the histone H3 variant CENP-A, which is localized exclusively at centromeres. Many fields of evidence suggest that CENP-A incorporation serves as the epigenetic mark maintaining centromere identity. CENP-A loading is under strict temporal control, and unlike conventional histones is uncoupled from DNA replication; instead, CENP-A is loaded exclusively during late anaphase through earl G1 of the cell cycle. Uncovering the mechanisms that control the precise timing and exclusive localization of CENP-A incorporation will deepen our understanding of aspects fundamental to cell division and epigenetics. In order to take an unbiased approach to discovering genes involved in centromeric function, we undertook a whole genome RNAi screen in Drosophila looking for genes whose depletion resulted in a loss of CENP-A phenotype. In our screen, we discovered that the constitutive centromere protein CENP-C and newly discovered protein CAL1 were in a complex with CENP-A and required CENP-A loading. Additionally, we discovered that RNAi of the drosophila homologues of EMI1 and Cyclin A result in a loss of CENP-A through premature activation of the anaphase promoting complex (APC), which we theorized resulted in the destruction of an unidentified APC substrate required for CENP-A loading. Intrigued by the connection between the timing of CENP-A loading and APC activation, we adapted an in-vitro degradation assay to assess the possibility that Drosophila CENP-A, CENP-C, or CAL1 could be our theorized APC substrate. Our assay indicated that these Drosophila proteins are not APC substrates. This finding led us to screen a candidate pool of 20 human proteins implicated in centromere function. Our screen discovered that HsKNL2/M18BP1, an essential centromere protein required for CENP-A loading, is an in-vitro substrate of the anaphase promoting complex. KNL2 degradation is mediated through destruction box (D-Box) and KEN box motifs. Mutation of the KEN and D-Boxes confers stability to KNL2 both in-vitro and in-vivo. Additionally, we discovered that centromeric localization of KNL2 depends on conserved residues in its SANTA (SANT-Associated) domain. Expression of GFP-nondegradable-KNL2 is able to rescue the CENP-A loading defect of KNL2 siRNA, indicating that KNL2 removal by the APC is not required for CENP-A loading. Further experiments are ongoing to characterize the phenotypic effects of KNL2 stabilization, particularly whether KNL2 stabilization is sufficient to decouple CENP-A loading from the cell cycle. We are also testing models to explain KNL2's localization to centromeres during periods of high APC activity and their consequences to centromere function. The discovery that KNL2 is an APC substrate provides a mechanistic link to explain the carefully regulated timing of CENP-A loading. Through a multidisciplinary approach we have assigned novel roles to genes required for CENP-A assembly in Drosophila; we further extended those principles to human biology and have possibly uncovered a mechanistic explanation for CENP-A's unique loading dynamics.
  • Google Books
    Also available: Print – pt. 1, 1972.
  • 2009
    Daniel Joseph Hogan.
    Circumstantial evidence suggests vast post-transcriptional regulatory networks in eukaryotes. There are scores of examples of mRNAs with rich post-transcriptional lives, and dozens of RNA-binding proteins and noncoding RNAs are suggested to have regulatory functions. While eukaryotic genomes encode hundreds of RNA-binding proteins and metazoans also encode dozens to hundreds of regulatory noncoding RNAs, few RNA-binding proteins or regulatory noncoding RNAs have been studied systematically, leaving unanswered basic questions about the scope and organization of post-transcriptional regulation in any eukaryote. First, I present studies aimed at uncovering some of the basic principles of post-transcriptional regulation in eukaryotes, via searching for the RNA targets of 40 proteins in the yeast Saccharomyces cerevisiae: a selective sample of the approximately 600 annotated and predicted RBPs as well as several proteins not annotated as RBPs. Second, I present a simple biochemical approach to identify direct targets of specific microRNAs, important noncoding regulatory RNAs, that regulate protein synthesis of most mammalian mRNAs. Third, I present experiments that uncover the magnitude and respective contributions of translational repression and mRNA decay of microRNA-mediated regulation. These studies apply simple, yet powerful approaches to systematically dissect various aspects of post-transcriptional regulation and uncover a wealth of novel information regarding regulation by RNA-binding proteins and microRNAs.
  • 2009 CRCnetBASE
    edited by Rajesh K. Gaur and John J. Rossi.
    Micro mining : computational approaches to miRNA discovery / Adam Grundhoff -- Animal microRNA gene prediction / Ola Snv?e and Pa<U+030a>l St?rom -- A suite of resources for the study of miRNA ontology and function / Praveen Sethupathy, Molly Megraw, and Artemis G. Hatzigeorgiou -- Regulation of translation and mRNA stability by Hfq-binding small RNAs in Escherichia coli / Hiroji Aiba -- Mechanisms by which microRNAs regulate gene expression in animal cells / Yang Yu and Timothy W. Nilsen -- The microRNAs of C. elegans / Mona J. Nolde and Frank J. Slack -- Isolation and characterization of small RNAs in C. elegans / Chisato Ushida and Yusuke Hokii -- MicroRNA tales in fly development / Utpal Bhadra ... [et al.] -- RNA interference and miRNAs in zebrafish / Alex S. Flynt, Elizabeth J. Thatcher, and James G. Patton -- Biogenesis and function of plant microRNAs / Zoltan Havelda -- Endogenous small RNA pathways in Arabidopsis / Manu Agarwal, Julien Curaba, and Xuemei Chen. How to assay miRNA expression : a technology guide / Mirco Castoldi, Vladimir Benes, and Martina U. Muckenthaler -- Methods to quantify microRNA gene expression / Lori A. Neely -- Regulation of alternative splicing by microRNAs / Rajesh K. Gaur -- Recent progress in polymerase II-mediated intronic microRNA expression systems / Shi-Lung Lin and Shao-Yao Ying -- MicroRNA-based RNA polymerase II expression vectors for RNA interference in mammalian cells / Anne B. Vojtek ... [et al.] -- Transgenic RNAi : a fast and low-cost approach to reverse genetics in mammals / Linghua Qiu and Zuoshang Xu -- Symphony of AIDS : an miRNA-based therapy / Yoichi R. Fujii -- MicroRNAs and cancer : connecting the dots / Sumedha D. Jayasena -- Mammalian transcriptional gene silencing by small RNAs / Daniel H. Kim and John J. Rossi -- Regulation of gene expression by RNA mediated transcriptional gene silencing / Kevin V. Morris.
  • 2007 Springer
    edited by Carole L. Bassett.
  • 2013
    Jaclyn Geok Yueen Lim.
    Adult stem cells are undifferentiated cells that are capable of both self-renewal and differentiation into a variety of specialized cells. Adult stem cell lineages have been identified in several organs including skin, blood, breast, intestine, bladder, skeletal muscle, prostate, and the testes. The changes in homeostatic conditions in these organs caused by tissue turnover or injury rely heavily on the pool of adult stem cells for cell replenishment. Therefore, the activity of adult stem cells must be tightly controlled, and many of these regulations are orchestrated by the stem cell niche, the local microenvironment in which stem cells reside. The fast generation cycle and the genetic tractability of fruit flies make the Drosophila testis stem cell niche an ideal system for the study of adult stem cell regulation. The Drosophila testis maintains two types of stem cells: germline stem cells (GSCs) which give rise to sperm, and cyst stem cells (CySCs) which differentiate into cyst cells that encapsulate germ cells. The somatic cyst cell lineage has been implicated to be required at several stages of spermatogenesis and play pivotal roles in germline proliferation, survival, and differentiation. This dissertation focuses on understanding the role of the cyst cell lineage in GSC maintenance and investigating the mechanisms by which cyst cells direct early germ cell differentiation. Previously, it has been proposed that CySCs are the source of instructive self-renewal cues for GSCs. In contrast to this model, I showed that early germ cells with GSC characteristics can be maintained in the absence of CySCs and cyst cells. These germ cells failed to enter the transit-amplifying program, which is regarded as the first step of differentiation in many adult stem cell lineages. My observations suggest that cyst cells provide a pro-differentiation environment for GSCs, and that this mechanism(s) may be repressed in CySCs which indirectly allow for GSC self-renewal. Encapsulation of germ cells by cyst cells is one of the differentiation-promoting mechanisms imposed by the soma on the germline, and I have uncovered that this process requires activation of the EGFR-Ras-MEK-MAPK pathway in differentiated cyst cells. Furthermore, I also showed that repression of EGFR activation in CySCs is important in maintaining the population of GSCs and CySCs at the niche, as premature activation of the pathway resulted in displacement of GSCs from the hub by somatic cells. Preliminary studies revealed a STAT target gene, Socs36E as a negative regulator of the EGFR pathway in CySCs to prevent out-competition of GSCs by somatic cells. To understand how the somatic cyst cells germline differentiation, I performed two genetic screens: an RNAi screen of genes that caused premature germ cell differentiation when misexpressed in the soma, and a misexpression screen of genes predicted to be cell-surface and secreted proteins. Three promising candidates were identified through these screens: two ribosomal subunits, Rpl13A and RpS10a; and a septate junction component, Neurexin IV. The two ribosomal proteins may be involved in the soma to promote germ cell encapsulation. Neurexin IV however, operates non-cell autonomously in cyst cells to regulate germ cell differentiation into spermatocytes. Together, the results of this dissertation emphasize the importance and complexity of the interaction between adult stem cells and their microenvironment in maintaining tissue homeostasis.
  • 2010
    Kenneth Demire Gibbs, Jr.
    Hematopoiesis is organized as a cellular hierarchy in which long-term self-renewing hematopoietic stem cells (HSC) give rise to all lineages of blood cells for the lifetime of an organism. Following the prospective isolation of mouse HSC in the late 1980s, research over the past two decades has focused on refining the phenotypic compartment where HSC reside, and identifying the numerous cell intrinsic and extrinsic mechanisms important for their maintenance. Many of these pathways are misappropriated in hematopoietic malignancies such as leukemia. It has been proposed that like normal hematopoiesis, leukemia is organized as a cellular hierarchy in which a leukemic stem cell population (LSC) is uniquely able to self-renew and gives rise to the heterogeneous lineages of cells that compose the tumor. This thesis will cover the mechanisms regulating the behavior of normal hematopoietic stem cells and leukemic stem cells. First, phospho-specific flow cytometry was utilized to define the responsiveness of human HSC to cytokine stimulation. This direct biochemical analysis demonstrated that HSC respond directly and rapidly to a broader number of direct stimuli in vitro and in vivo than previously appreciated. This included Granulocyte Colony Stimulating Factor (G-CSF), a cytokine used clinically to mobilize HSC to the peripheral blood prior to bone marrow transplantation. The direct HSC response to G-CSF is shown to affect the behavior of the HSC pool in vitro (causing cell cycle entry and increased proliferation), and in vivo (negatively regulating active hematopoiesis in the short-term). Thus, it is proposed that cytokines, long known to impact the function of mature lineage cells, also are important for the steady-state regulation of HSC activity. Next, two mouse models of AML were utilized to determine the mechanisms important for regulation of LSC activity. It is demonstrated that the catalytic p110[lower case delta] subunit of Phosphoinositide 3-kinase (PI3K), which is constitutively activated and drives proliferation in human AML blasts, is dispensable for de novo leukemogenesis and LSC activity in AML driven by retroviral transfer of MLL-AF9 or HoxA9-Meis1 (H9M) oncogenes into early hematopoietic progenitors. Finally, the LSC in H9M AML are identified. Surprisingly, multiple phenotypic compartments were equally enriched for LSC activity. This was also the case when LSC activity in MLL-AF9 driven AML was assessed. Putative genetic LSC maintenance signatures for each model were also identified. There was both overlap and stark contrast in cell surface phenotypes of the LSC-enriched compartments and the genetic LSC maintenance signatures in these closely related leukemias. These data suggest that like normal hematopoiesis, a hierarchy does exist in which self-renewing cells give rise to terminally differentiated progeny. However, unlike HSC activity, which can be isolated to a single compartment by cell surface phenotype that is commonly regulated between individuals, LSC activity is a cell state that can be independent of surface phenotype and with context-specific regulatory mechanisms.
  • 2011
    Michael Wong.
    Naïve CD4+ T cells are precursor cells that differentiate into distinct lineages of T helper (TH) cells upon cellular activation. The work presented here describe how we identified the soluble factors required for the differentiation of human TH17 and TH9 cells, which are two novel TH subsets implicated in the pathogenesis of various autoimmune and allergic disorders, respectively. We also performed functional analysis with human TH1, TH2 and TH17 cells, demonstrating that different TH cells drive monocytes to differentiate into specialized DC subsets. Collectively, we believe that these data have significant implications for the treatment of inflammatory disorders. In order to determine the factors that drive human TH17 differentiation, we hypothesized that a subset of TLR ligands could induce PBMCs to secrete TH17-polarizing factors. We identified that conditioned media from TLR4- and TLR8/7-stimulated cultures could promote IL-17 production. Using a proteomics screening approach, we demonstrated that a combination of pro-inflammatory cytokines synergistically promote human TH17 differentiation. TH17-polarizing cytokines upregulated the expression of the transcription factor ROR[Gamma]t and drove the expansion of memory TH17 and TH1/17 cells. The data presented in Chapter 2 indicate that the pathways driving murine and human TH17 responses are quite different, which may diminish the value of various mouse studies in the treatment of TH17-driven diseases. In collaboration with the laboratory of Edgar Engleman, we demonstrate that TH cells mediate the differentiation of monocytes into distinct DCs. Importantly, TH17 cells drive the formation of TH17-promoting DCs (DCTh17), whereas TH1 and TH2 cells drive the formation of TH1- and TH2-promoting DCs (DCTh1 and DCTh2), respectively. Blocking the TH1 cytokine IFN-[Gamma] inhibited DCTh1 formation, whereas neutralizing the TH2 cytokines IL-4 and IL-13 inhibited DCTh2 formation. Studies of psoriasis and atopic dermatitis skin lesions indicate that TH cells are closely associated with monocytes and DCs in situ, suggesting that this pathway contributes to disease pathogenesis. These data illustrate a positive feedback loop between TH cells, monocytes and DCs that may contribute to the ongoing inflammation observed in various autoimmune and allergic disorders. In Chapter 4, the factors that promote human TH9 differentiation are characterized, and we provide evidence that IL-21 is a potent enhancer of IL-9 secretion. TH9 cells generated in vitro exhibit a heterogeneous phenotype based on the expression of the transcription factors GATA-3 and Foxp3. Finally, a small population of memory CD4+ T cells cultured under TH17-polarizing conditions secreted IL-9, IL-17 and IFN-[Gamma], suggesting considerable lineage plasticity among human TH cells. Taken together, these data indicate a complex cytokine network in the regulation of human TH17 and TH9 cells.
  • 2015 Springer
    Rodney D. Geisert, Fuller W. Bazer, editors.
    Over the past few decades technological advances in transcriptomics, proteomics, metabolomics, and glycomics, along with the ability to selectively knockout genes of interest, have greatly advanced our understanding of the maternal-conceptus interactions that are essential for the establishment and maintenance of a successful pregnancy. This knowledge provides the basis for new research endeavors to address infertility, embryonic loss and recurrent abortion in humans, captive wild animals and important farm species. This book brings together current reviews from leading experts to address the diversity of mechanisms by which species establish and maintain pregnancy. Implantation in rodents, dogs, pigs, cattle, sheep, horses, primates, humans and embryonic diapause in wild species are discussed. The reviews provide readers with the latest knowledge on the role of the endometrial steroid receptors, adhesion factors, cytokines, interferons, steroids, prostaglandins, growth factors and immune cells involved in the regulation of conceptus development. .
  • 2010
    Eon Joseph Rios.
    Cell surface receptor regulation maintains proper responses to external signals and disregulation of receptors can have drastic effects. We found that RabGEF1, a guanine exchange factor (GEF) for the endocytic regulating small GTPase Rab5, regulates IgE+antigen (Ag)-induced Ras signaling in mast cells and skin homeostasis in vivo. To further understand RabGEF1's role in mast cell function we investigated if RabGEF1 generally regulates mast cell signaling by examining a number of modes of mast cell activation. Like IgE+Ag stimulation, RabGEF1 deficient (-/-) mast cells demonstrated enhanced activation after exposure to stem cell factor (SCF), the ligand for the receptor tyrosine kinase c-kit. Enhanced responses correlated with delayed c-kit and IgE receptor (FcεRI) internalization suggesting a proximal role of RabGEF1 in regulating mast cell signaling events. To dissect the roles of RabGEF1 and its domains in regulating mast cell biology we lentivirally expressed a panel of RabGEF1 mutants in RabGEF1-/- mast cells. We found that RabGEF1 (1) harbors ubiquitin (Ub) ligase activity within an N-terminal A20 zinc finger domain, (2) binds to Ub and localizes to membranes through amino acids 1-150, (3) interacts with Rabaptin-5, a Rab5 effector, through a C-terminal coiled coil (CC) domain and, (4) activates Rab5 with a central VPS9 domain. Despite containing a number of domains, only the VPS9 was crucial to restore wildtype activation of RabGEF1-/- cells after IgE+Ag stimulation. Moreover, lack of the VPS9 or CC domain diminished Rabaptin-5 levels and reduced surface FcεRI and β1 expression on mast cells suggesting that these domains are important for receptor homeostasis. Using shRNA knockdown of Rabaptin-5 we identified a novel role for Rabaptin-5 in maintaining FcεRI and β1 surface expression by increasing surface stability and receptor half-life. The reduced FcεRI and β1 surface levels in Rabaptin-5 deficient cells attenuated sensitivity to antigen induced adhesion, migration, and cytokine production in these cells. Despite Rabaptin-5's in vitro documented role as a Rab5 effector, Rab5 dependant processes (i.e., receptor internalization or endosome fusion) were unaffected by Rabaptin-5 deficiency and challenge the current thoughts of Rab5 processes in intact cells. These data show the importance of receptor trafficking in regulating mast cell activation.
  • 2012
    Simona Rosu.
    Sexually reproducing organisms undergo meiotic recombination to increase genetic diversity and to ensure correct segregation of chromosomes at the first meiotic division. During meiotic recombination, DNA double-strand breaks (DSBs) are deliberately induced, and a subset of the breaks are repaired as inter-homolog crossovers (COs). Inter-homolog COs provide physical connections between homologous chromosomes that enable them to segregate away from each other. Despite reliance on COs for chromosome segregation, few COs are made per chromosome pair, implying mechanisms for robust CO control. In addition, DNA breaks are potentially dangerous lesions, therefore DSB formation and repair must be tightly regulated, both to ensure the formation of COs, but also to protect against deleterious effects. This thesis provides new insights into mechanisms that regulate DSB formation and repair, using the nematode Caenorhabditis elegans as a model organism. CO regulation mechanisms were probed by monitoring the repair outcome of a DSB induced at a defined site at different stages of meiotic progression, in WT and mutant situations. This analysis uncovered a previously unappreciated level of control in restricting CO number, which is to limit the duration of access to the homolog as a repair template. In addition, this work showed that when no competing breaks are present, a single induced DSB is converted to a CO with high efficiency. This feature helps achieve CO assurance. Insights into regulation of DSB formation were uncovered from the identification and characterization of novel protein DSB-2. DSB-2 is required for break formation, but is dispensable for later steps of meiotic recombination. DSB-2 localizes to chromatin during the time of break formation, suggesting it acts to promote competence for DSB formation. Both approaches presented in this thesis uncovered evidence for negative feedback regulatory mechanisms, suggesting a model wherein formation of CO-eligible recombination intermediates signals shutdown of DSB formation as well as shutdown of inter-homolog access. The proposed regulatory networks provide a mechanism to both ensure sufficient breaks and COs are made, and to shut down these processes to prevent deleterious effects as meiosis progresses.
  • 2016 Springer
    Sajal Chakraborti, Naranjan S. Dhalla, editors.
  • 2011 Springer
    edited by Helge Grosshans.
    MicroRNA biogenesis and function : an overview / Rene F. Ketting -- Regulation of pri-miRNA processing through Smads / Akiko Hata and Brandi N. Davis -- Stimulation of pri-miR-18a processing by hnRNP A1 / Gracjan Michlewski, Sonia Guil, and Javier F. Cáceres -- KSRP promotes the maturation of a group of miRNA precursors / Michele Trabucchi ... [et al.] -- Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor / Sally Fujiyama-Nakamura, Kaoru Yamagata, and Shigeaki Kato -- Autoregulatory mechanisms controlling the microprocessor / Robinson Triboulet and Richard I. Gregory -- Regulation of pre-miRNA processing / Nicolas J. Lehrbach and Eric A. Miska -- The effect of RNA editing and ADARs on miRNA biogenesis and function / Bret S.E. Heale, Liam P. Keegan, and Mary A. O'Connell -- MiRNAs need a trim regulation of miRNA activity by trim-NHL proteins / F. Gregory Wulczyn ... [et al.] -- Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression / Nicole-Claudia Meisner and Witold Filipowicz -- Turnover of mature miRNAs and siRNAs in plants and algae / Heriberto Cerutti and Fadia Ibrahim -- MicroRNases and the regulated degradation of mature animal miRNAs / Helge Grosshans and Saibal Chatterjee.
    Also available: Print – 2010
  • 2010
    Michael R. Howitt.
    Microbes can colonize harsh and dynamic environments. Often, this ability depends on rapid responses through directed motility. Members of the Epsilon proteobacteria are found in many 'extreme' environments, including the human stomach. We discovered that Helicobacter pylori establish bacterial colonies deep in the gastric glands, and identified a novel protein, ChePep, necessary to colonize this niche. By tracking the movement of single bacteria we found that mutants lacking ChePep cannot control the rotation of their flagella and swim with abnormally frequent reversals and even sustain bursts of movement backwards. Genetic experiments show that ChePep regulates flagellar rotation through the chemotaxis signaling system. By examining H. pylori within a microscopic pH gradient, we determined that ChePep is critical for normal chemotactic behavior. We expressed ChePep from the zoonotic pathogen Campylobacter jejuni, and the deep sea hydrothermal vent inhabitant Caminibacter mediatlanticus in H. pylori and found that ChePep is functionally conserved across the [epsilon]-proteobacteria. ChePep represents a new family of chemotaxis regulators unique to the [epsilon]-proteobacteria, and illustrates the differing strategies that microbes have evolved to control motility.
  • 2006
    Everett Hurteau Meyer.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Stephani Sara Dean.
    Status: Not Checked OutLane Catalog Record
  • 2011
    Saul Abraham Villeda.
    Aging in mammals is associated with a decline in the function and regenerative capacity of tissue specific stem cells. In the adult central nervous system the age-related decline of these functional stem/progenitor cells (NPCs), and subsequently neurogenesis, is correlated with impairments in cognitive functions including learning and memory. Interestingly, changes occurring in the systemic milieu of an organism, such as those induced through increased exercise, have been shown to partially mitigate this cellular decline. While previous studies have examined intrinsic molecular mechanisms underlying NPC aging and decreased neurogenesis at the cellular level, a gap still exists in elucidating how age-dependent NPC function is impaired by systemic changes associated with aging. This dissertation addresses the role of the aging systemic milieu in the regulation of adult neurogenesis and cognition, and seeks to identify individual factors responsible in part for the age-related decline. Chapter 1 reviews the cellular process of adult neurogenesis and discusses its regulation during aging by intrinsic and extrinsic factors, as well as its contribution to synaptic plasticity and cognitive functions. Chapter 2 focuses on the age-related decrease in adult neurogenesis and asks whether systemic molecular changes naturally occurring with age contribute to this decline. Using heterochronic parabiosis, in which the circulatory systems of two animals are adjoined, we show that blood-borne factors present in the systemic milieu can inhibit or promote adult neurogenesis in an age dependent fashion in mice. Furthermore, we demonstrate functional relevance for changes occurring in the systemic milieu, as exposing a young animal to an old systemic environment, or to plasma from old mice, decreased synaptic plasticity and impaired spatial learning and memory. Chapter 3 focuses on individual systemic factors and demonstrates that age-related changes in systemic chemokine levels negatively regulate neurogenesis and learning and memory. Using a targeted proteomic screen, we identified a conserved subset of blood borne chemokines - including CCL2/MCP-1 and CCL11/Eotaxin -- whose plasma levels correlate with reduced neurogenesis observed in normal and experimental (i.e. heterochronic parabiosis) aging. Additionally, mimicking an aged systemic environment by increasing the level of CCL11 in the periphery of young adult mice resulted in a decrease in neurogenesis and impaired spatial learning and memory. Chapter 4 focuses on [Beta]2-microglobulin (B2M), another identified systemic factor that increases with aging and negatively correlates with the age-related decline in neurogenesis, and examines its role in regulating adult hippocampal neurogenesis. Using primary cell models we show that exposure to recombinant B2M protein inhibits NPC function and neuronal differentiation in vitro. Furthermore, we show that local exposure of a young adult hippocampus to B2M decreases neurogenesis and impairs cognitive function in vivo. Additionally, we show that the inhibitory effects of B2M are mediated by MHCI. Lastly, using a genetic mouse model that lacks B2M expression we show that neurogenesis is improved in adult animals in an age-dependent manner. Chapter 5 contains a summary and conclusion of the results presented in this dissertation, highlighting the influence of the aging systemic milieu on neuroplasticity and cognition.
  • 2006
    Rachel Gail Henderson.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Odmara Liz Barreto-Chang.
    Electrical activity is a potent trophic factor that promotes the survival of many populations of neurons. L-type calcium channels (LTCs) are particularly effective at promoting survival of neurons during development, in part by activating transcription factors such as CREB. Mutation of the LTC CaV1.2 causes Timothy Syndrome (TS), a disorder characterized by cardiac arrhythmias, webbing of fingers and toes, and autism. The TS mutation leads to loss of voltage-dependent inactivation (VDI) of the channel. Although it is known that VDI is critical for the transition between the open and resting states of the channel, the role that channel inactivation plays in cell signaling and neuronal development is poorly understood. The work in this dissertation shows that the TS mutation impairs CaV1.2-dependent neuronal survival and prevents activation of the transcription factor CREB. By using TS channels that contain pore mutations that prevent Ca2+ flux, we found that the ability of TS channels to cause apoptosis is independent of Ca2+ flux through the channel. Conversely, a novel leucine to proline mutation at position 1368 restores VDI to TS channels and prevents TS-dependent apoptosis and inhibition of CREB. These findings support the idea that CaV1.2 conveys two signals that together regulate activity-dependent neuronal survival and activation of CREB: a signal that depends on the channel conformation and a signal that depends on calcium influx through the channel. These results provide new insights into the mechanisms by which the L-type calcium channels activate transcription and regulate neuronal survival during development.
  • 2005 Springer
    R. Brehm, K. Steger.
  • 2012
    Christopher Paul Arnold.
    Stem cell self-renewal is dynamically regulated in response to extrinsic stimuli, but the intrinsic mechanisms that mediate the effects of these stimuli remain elusive. Emerging evidence suggests that miRNAs, an abundant class of ~22-nt small regulatory RNAs, play key roles in controlling the post-transcriptional genetic programs in stem and progenitor cells. We systematically examined miRNA expression profiles in various normal and aberrant adult tissue-specific stem and progenitor cells. Delineation of miRNAs whose expression correlated with changes in the self-renewal properties during normal development and as the result of mutant perturbations permitted the identification of miRNAs that marked stem to progenitor transition, termed SPT-miRNAs. Expression of SPT-miRNAs correlated with the exit from a self-renewing state as well as reduced self-renewal capacity in various normal and leukemia stem cells, suggesting that they may play a role in post-transcriptional gene silencing of key mediators of stem cell self-renewal. Consistent with this hypothesis, premature expression of a subset of these miRNAs could diminish the reconstitution potential of hematopoietic stem cells (HSCs) and the self-renewal of embryonic stem cells (ESCs). Furthermore, SPT-miRNAs targeted genes necessary for the self-renewal of HSCs, suggesting that up-regulation of these miRNAs permitted the efficient silencing of self-renewal programs during the stem to progenitor transition. Given the functional overlap of SPT-miRNAs in both embryonic and adult stem cells, we hypothesized that the expression of some SPT-miRNAs may be actively repressed by extrinsic signaling cues in stem cells at multiple developmental stages to potentiate their self-renewal. By subjecting ESCs to various culture conditions that diminished their self-renewal efficiency, we observed an up-regulation of a subset of SPT-miRNAs; in particular, members of the miR-181 family. Ectopic expression of this miRNA reduced ESC self-renewal whereas its deletion augmented ESC self-renewal in serum-free medium. These changes in self-renewal were attributable to simultaneous modulation of ESC proliferation and lineage commitment via target interactions with Lin28A, Spry4, and Dusp6. Finally, we found that the BMP-signaling pathway, necessary for the efficient self-renewal of ESCs, played a key role in the suppression of miR-181a. Collectively, these results reveal how extrinsic signaling cues mediate the quantitative post-transcriptional regulation of stem cell self-renewal programs via the modulation of miRNAs. Our study demonstrated one approach to identify and investigate the role of intrinsic regulators and provided novel insight into how to uncover the intrinsic regulators of stem cell self-renewal with implications on manipulation of stem cell expansion ex vivo.
  • 2010
    Daniel Richard Calnan.
    The FoxO family of transcription factors plays an important role in longevity and tumor suppression by regulating the expression of a wide range of target genes. FoxO3 has recently been found to be associated with extreme longevity in humans and to regulate the homeostasis of adult stem cell pools in mammals, which may contribute to longevity. The activity of FoxO3 is controlled by a variety of post-translational modifications that have been proposed to form a 'code' affecting FoxO3 subcellular localization, DNA binding ability, protein-protein interactions and protein stability. Lysine methylation is a key post-translational modification on histones that regulate chromatin accessibility and is a key part of the 'histone code'. However, whether lysine methylation plays a role in modulating FoxO3 activity has never been examined. I found that the methyltransferase Set9 directly methylates FoxO3 in vitro and in cells. Using a combination of tandem mass spectrometry and methyl-specific antibodies, I find that Set9 methylates FoxO3 at a single residue, lysine 271, a site previously known to be deacetylated by Sirt1. Methylation of FoxO3 by Set9 decreases FoxO3 protein stability, while slightly increasing FoxO3 transcriptional activity. The modulation of FoxO3 stability and activity by methylation may be critical for fine-tuning cellular responses to stress stimuli, which may in turn affect FoxO3's ability to promote tumor suppression and longevity. Post-translational modifications control many aspects of FoxO3 activity, including protein stability, subcellular localization and binding partner association. To analyze whether FoxO3 functions primarily alone, or in a complex with other factors, I used size exclusion chromatography to assess the size of the potential FoxO3 protein complexes in cellular extracts. I found that FoxO3 is present in fractions with a relative molecular weight larger ranging from 250 to 700 kDa. Interestingly, the cytoplasmic fraction of FoxO3 appears to be in a larger complex than the nuclear fraction, suggesting that FoxO3 is present in more than one protein complex in cells. To identify novel binding partners of FoxO3 that could be present in these large molecular-weight protein complexes, I conducted a tandem affinity purification (TAP) of dual tagged FoxO3 in HeLa S3 cells followed by liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS) of the elution from the immunoprecipitation. I identified over 1,000 potential FoxO3 binding partners that were not present in the control immunoprecipitation. These candidate binding partners included protein kinases (e.g. mTOR, MAPKs), other tumor suppressors (e.g. p65, p130) and oncogenes (e.g.Myb), as well as proteins that contain a methyl lysine (e.g. WDR17, PHF3) and acetyl lysine (e.g. BAZ2B, BRD1) binding domains. Taken together, these results suggest that FoxO3 functions in large protein complexes that could affect FoxO3 activity. The formation of FoxO3-containing complexes could be triggered by FoxO3 post-translational modifications. By increasing our understanding of the regulation of FoxO3, as well identifying possible interacting proteins, we further our knowledge of the pathways important for both longevity and age related diseases, including cancer.
  • 2010
    Megan Leigh Insco.
    Status: Not Checked OutLane Catalog Record
  • 2006
    Taavi Neklesa.
    Status: Not Checked OutLane Catalog Record
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2000
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • ScienceDirect
    edited by W.E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2001
  • 2006 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2006
  • 2006 ScienceDirect
    edited by William E. Balch, Channing J. Der, Alan Hall.
    Also available: Print – 2006
  • pt. A-B, 2004. ScienceDirect
    pt. B ScienceDirect
    edited by David P. Siderovski.
    Also available: Print – pt. A-B, 2004.
  • 2015 Springer
    Maria Cristina Galli, Mercedes Serabian, editors.
    United States Food and Drug Administration Regulation of Gene and Cell Therapies -- The National Institutes of Health Oversight of Human Gene Transfer Research: Enhancing Science and Safety -- Regulatory Oversight of Cell and Gene Therapy Products in Canada -- Overview of the Regulatory Oversight Implemented by the French Regulatory Authorities for the Clinical Investigation of Gene Therapy and Cell Therapy Products -- Regulation of Clinical Trials with Advanced Therapy Medicinal Products in Germany -- Marketing Regulatory Oversight of Advanced Therapy Medicinal Products (ATMPs) in Europe: The EMA/CAT Perspective -- Requirements for Clinical Trials with Gene Therapy and Transplant Products in Switzerland -- Regulatory Frameworks for Gene and Cell Therapies in Japan -- Regulatory Oversight of Gene Therapy and Cell Therapy -- Regulation of Cell and Gene Therapy Medicinal Products in Taiwan -- Regulatory Oversight of Cell- and Tissue-Based Therapeutic Products and Gene Therapy Products in Singapore -- The Regulatory Pathway for Advanced Cell Therapy and Gene Therapy Products in Brazil: A Road to Be Built -- Index.
    Also available: Print – 2015
  • 2014 Springer Protocols
    edited by Gaetano Vitale and Francesca Mion, Department of Medical and Biological Sciences, University of Udine, Udine, Italy.
  • 2010
    Gwen Liu.
    MicroRNA (miRNA) genes, which encode an abundant class of ~22-nucleotide (nt), evolutionarily conserved small RNAs, control a fundamental layer of genetic programs at the post-transcriptional level. However, little is known about how the activity of miRNA genes is regulated and how the regulatory information controlling their activity is encoded. Interestingly, mature miRNAs can often be classified into large families consisting of members with identical seeds (nucleotides 2 through 8 of the mature miRNAs) and highly homologous ~22-nt mature miRNA sequences, but with divergent sequences and structural elements beyond their mature miRNAs. Here we investigated whether members of a miRNA gene family that encode identical or nearly identical mature miRNAs are functionally interchangeable in vivo and if not, why? We compare the activities of the mir-181 gene family in promoting double positive T cell development and show that miRNA genes that encode identical to nearly identical mature miRNAs can have distinct activities. The differences in activity between mir-181a-1 and mir-181c are largely determined by their unique primary/precursor-miRNA (pri/pre-miRNA) loop nucleotides, and the differences in activity between mir-181a-1 and mir-181b-1 are determined by both the pri/pre-miRNA loop and stem. Furthermore, the organization of mir-181a-1/b-1 in a cluster is important for its full activity. We also show that mir-181 family members can differentially regulate target genes quantitatively, and that some target genes can be upregulated. Taken together, we have demonstrated that regulatory information encoded in a miRNA gene beyond the mature miRNA plays a critical role in controlling the activity of the miRNA gene, suggesting that miRNA family members could have evolved different functions through their divergent miRNA gene sequences and structural elements beyond their mature miRNAs. Although, proteins may have evolved to recognize the structural and sequence elements of the pri/pre-miRNAs, we suggest that the regulatory information encoded in the structured pri/pre-miRNA may be directly interpreted through target and pri/pre-miRNA interactions.
  • 2006 ScienceDirect
    Eric H. Davidson.
  • 2007 Springer
    edited by Setsuro Ebashi and Iwao Ohtsuki.
    Also available: Print – 2007
  • 2009 Springer
    Vinagolu K. Rajasekhar, Mohan C. Vemuri, editors.
  • 2015 Springer Protocols
    2014 Springer Protocols
    edited by Gordon G. Carmichael.
    Diverse functions and mechanisms of mammalian long noncoding RNAs -- Sequence-defined oligoaminoamides for the delivery of siRNAs -- A biochemical approach to identify direct microRNA targets -- Native gel analysis for mammalian microRNPs assembled from pre-microRNAs -- Identification and validation of miRNA target sites within nontraditional miRNA targets -- Fractionation of non-polyadenylated and ribosomal-free RNAs from mammalian cells -- Affinity purification of long noncoding RNA-protein complexes from formaldehyde cross-linked mammalian cells -- RNA pulldown protocol for in vitro detection and identification of RNA-associated proteins -- nRIP-seq: A technique to identify RNA targets of an RNA binding protein on a genome-wide scale -- Analysis of the subcellular distribution of RNA by fluorescence in situ hybridization -- RNA fluorescence in situ hybridization in cultured mammalian cells -- Locating RNAs in situ with FISH-STIC probes -- Rapid and efficient elimination of specific nuclear noncoding RNAs in mammalian cells with antisense oligonucleotides -- On using magnesium and potassium ions in RNA experiments -- Studying the affinity, kinetic stability, and specificity of RNA/protein interactions: SINE ncRNA/Pol II complexes as a model system
  • 2011
    Leticia Cristina Britos Cavagnaro.
    Bacteria have evolved robust systems to sense environmental stimuli and limit proliferation under unfavorable conditions. While bacterial defense mechanisms have been characterized, the integration of environmental signals into the regulation of growth and development remains for the most part a mystery. The goal of this work was to identify the mechanisms by which the aquatic bacterium C. crescentus integrates information from the environment into the regulation of growth and development. I studied the transcript and protein changes that occur in C. crescentus in response to nutritional deprivation. The integration of high-throughput transcriptome and proteome analyses allowed me to obtain a comprehensive view of the process. The transcriptome changes were the starting point for the identification of genetic regulatory pathways involved in the response to environmental challenge. The alternative sigma factor SigT, one of the key regulators identified, was shown to activate the expression of a core set of general starvation-stress response genes that are cell cycle regulated during normal development in C. crescentus, and are candidates to mediate the inhibition of growth and division occurring upon environmental challenge. Furthermore, the SigT pathway was shown to directly integrate information from the environment into the circuit that regulates cell cycle progression, through the post-transcriptional regulation of the CtrA master regulator. The molecular analyses were complemented with cell biology studies, which revealed the differential effects of starvation and osmotic stress on chromosome replication and polar morphogenesis in swarmer cells. Overall, this work contributes to the emerging understanding of how the well-characterized regulatory circuit that controls cell cycle progression in C. crescentus integrates environmental signals.
  • 2006 Cold Spring Harb Lab Press
    SU Catalog (SearchWorks) Click LINK above for Print location/circulation status.
    meeting organized by Bruce Stillman and David Stewart.
    Mechanism and biology of RNAi -- Genome-wide approaches -- Small RNAs in development -- Telomeres and cancer -- End regulation of transcripts -- RNPs and RNA editing -- Biology of short RNAs -- Control of gene expression by noncoding RNAs -- Heterochromatin -- Quality control, messenger RNA turnover, and translational control.
  • 2012 Springer
    Bibekanand Mallick, Zhumur Ghosh, editors.
    pt. 1. Basics -- pt. 2. Methods -- pt. 3. Applications.
  • 2012 Springer
    Wolfgang R. Hess, Anita Marchfelder.
    This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.
  • 2008 Springer
    Shuiping Jiang, editor.
  • 2005 Springer
    Leonie S. Taams, Arne N. Akbar, Marca H.M. Wauben, editors.
    Also available: Print – 2005
  • 2013 Springer
    Kimberly A. Sackheim, editor.
    "Designed in a concise, easy-to-read style for a wide variety of medical occupations, the Rehab Clinical Pocket Guide is the ideal, handy reference for rehabilitation professionals and other health providers. Divided into four sections that cover inpatient care, clinical strategies, outpatient care, and additional diagnostics and therapeutics, this is the first book of its kind to contain all of the relevant clinical information needed on the rehabilitation unit, including specific admission order sets and topics such as medication dosing, consultant recommendations, specific rehabilitation goals and treatments, and even billing details for various diagnoses. The Rehab Clinical Pocket Guide offers all the clinical material needed to properly treat patients and excel in the field of physical medicine and rehabilitation and will prove an indispensable resource for medical students, residents, physicians, therapists and nutritionists."--P. 4 of cover."
  • 1960-
    Eugene J Taylor, editor.
    Status: Not Checked OutLane Catalog Record
  • 2015 CRCnetBASE
    edited by Richard J. Siegert [and] William M.M. Levack.
    Evidence-based goal setting : the trials and tribulations / Levack, W.M.M. & Siegert, R.S. -- Psychology & goal setting : providing a theoretical foundation / Siegert, R.S., O'Connell, C., & Levack, W.M.M -- Ethics & goal setting : providing a moral foundations / Levack, W.M.M., Pickering, N., Siegert, R.S. -- Goal setting as shared decision-making / Playford, D. -- Meaning as a smarter approach to goals in rehabilitation / McPherson, K.M., Kayes, N.M., Kersten, P. -- Goal attainment scaling in adult neurorehabilitation / Ashford, S., Turner-Stokes, L. -- Goal attainment scaling in paediatric rehabilitation / Steenbeek, D., Gorter J.W., Ketelaar, M., Galama, K., Lindeman, E. -- Applying the international classification of function, disability, and health to goal setting in rehabilitation / Rauch, A., Scheel-Sailer, A. -- An occupation-based, client-centred approach to goal planning and measurement / Doig, E., Fleming, J -- A theoretically based approach to goal setting / Scobbie, L., Dixon, D. -- Goal orientation and goal setting as a topic in German medical rehabilitation research / Meyer, T., Pohontsch, N. -- Goal-setting in social competence treatment after brain injury / Hawley, L.A., Newman, J. -- Goal setting in the context of self-management after stroke / Jones, F. -- Goal-setting and older adults / Parsons, J. -- Goal setting in paediatric rehabilitation / Wiart, L. -- Goals and goal-setting for people with aphasia, their family members, and clinicians / Sherratt, S., Worrall, L., Hersh, D., Howe, T., Davidson, B. -- Goal setting for stroke rehabilitation / Rosewilliams, S.B. -- Current trends and future direction for research and clinical practice / Siegert, R.S., and Levack, W.M.M.
  • 2013 Cambridge
    edited by Robert Iansek, Meg E. Morris.
    Functional neuroanatomy and physiology in movement disorders / Nicola Pavese and David J. Brooks -- Pathophysiology of basal ganglia disorders : neurophysiological investigations / Alfredo Berardelli and Antonio Suppa -- Medical management of movement disorders / Louis C.S. Tan and Kulthida Methawasin -- Functional neurosurgery of movement disorders / Travis S. Tierney and Andres M. Lozano -- Peripheral surgical and movement modification-therapies for movement disorders / Barry Rawicki -- The role of physiotherapy in the rehabilitation of people with movement disorders / Lynn Rochester, Sue Lord, and Meg E. Morris -- The role of occupational therapy in the rehabilitation of people with movement disorders / Ana Aragon, Jill Kings, and Diane Playford -- The role of nursing in the rehabilitation of people with movement disorders / Allison F. Williams, Siok Bee Tan, and Victor McConvey -- The role of neuropsychology in the rehabilitation of people with movement disorders / Georg Dirnberger and Marjan Janahshahi -- The role of the speech pathologist in the rehabilitation of people with movement disorders / Deborah Theodoros -- The role of social work in the rehabilitation of people with movement disorders / Ralph Hampson and Lynette Joubert -- Rehabilitation principles in chronic neurological conditions in adults and children / John Olver .. [et al.] -- Rehabilitation of Parkinson's disease / Robert Iansek and Meg E. Morris -- Rehabilitation of parkinsonian syndromes / David R. Williams -- Rehabilitation of Huntington's disease / Belinda Bilney and Alan Pearce -- Rehabilitation of dystonia / Daniele Volpe and Giovanni Abbruzzese -- Rehabilitation of Friedreich ataxia / Sarah Milne [and others] -- Rehabilitation of cerebral palsy / Pam Thomason and H. Kerr Graham -- Rehabilitation of developmental disorders and motor dysfunction / Nicole Rinehart [and others] -- Selection of clinical outcome measures in rehabilitation of people with movement disorders : theory and practice / Jennifer L. McGinley and Mary Danoudis.
  • 2016 Springer
    A.B. Imhoff [and 4 others], eds.
  • v.1-2=, 2011 ClinicalKey
    [edited by] Terri M. Skirven [and three others].
    Vol. 1. Anantomy and Kinesiology -- Examination -- Skin and Soft Tissue Conditions -- Hand Fractures and Joint Injuries -- Tendon Injuries and Tendinopathies -- Nerve Lacerations -- Compression Neuropathies -- Proximal Nerve Conditions -- Surgical Reconstruction for Nerve Injuries -- Vascular and Lymphatic Disorders -- Stiffness of the Hand -- Vol. 2. Common Wrist Injuries -- Common Elbow Injuries -- Common Shouler Conditions -- Complex Traumatic Conditions -- Arthritis and Related Autoimmune Disorders -- Pain -- Special Techniques of Therapist's Intervention -- Orthotic Intervention: Principles and Techniques -- Other Special Populations -- The Injured Worker -- Evidenced-Based Practice: Integrating Clinical Expertise and Systematic Research.
  • 2010 ScienceDirect
    by Emma K. Stokes.
    Outcome measurement and practice -- International classification of functioning, disability and health (ICF) -- How to choose an outcome measure -- Reliability : error in measurement -- Validity -- Measuring change -- Measuring mobility -- Measuring physical activity -- Measuring fatigue -- Measuring neurological conditions and rehabilitation -- Evaluating satisfaction.
  • 2009
    edited by Christine Arenson ... [et al.].
    Status: Not Checked OutLane Catalog Record
  • pt. A-B., 2006
    edited by Mario C. Raviglione.
    Status: Not Checked OutLane Catalog Record
  • 2013
    Paul Farmer [and others].
    "Bringing together the experience, perspective and expertise of Paul Farmer, Jim Yong Kim, and Arthur Kleinman, Reimagining Global Health provides an original, compelling introduction to the field of global health. Drawn from a Harvard course developed by their student Matthew Basilico, this work provides an accessible and engaging framework for the study of global health. Insisting on an approach that is historically deep and geographically broad, the authors underline the importance of a transdisciplinary approach, and offer a highly readable distillation of several historical and ethnographic perspectives of contemporary global health problems.The case studies presented throughout Reimagining Global Health bring together ethnographic, theoretical, and historical perspectives into a wholly new and exciting investigation of global health. The interdisciplinary approach outlined in this text should prove useful not only in schools of public health, nursing, and medicine, but also in undergraduate and graduate classes in anthropology, sociology, political economy, and history, among others"--Provided by publisher.
  • 2011 Springer
    Carsten Nieder, Johannes A. Langendijk, editors.
  • 2010 Springer
    Luciano L'Abate, Mario Cusinato, Eleonora Maino, Walter Colesso, Claudia Scilletta.
    Relational competence the set of traits that allow people to interact with each other effectively enjoys a long history of being recorded, studied, and analyzed. Accordingly, Relational Competence Theory (RCT) complements theories that treat individuals' personality and functioning individually by placing the individual into full family and social context. The ambitious volume Relational Competence Theory: Research and Mental Health Applications opens out the RCT literature with emphasis on its applicability to interventions, and updates the state of research on RCT, examining what is robust and verifiable both in the lab and the clinic. The authors begin with the conceptual and empirical bases for the theory, and sixteen models demonstrate the range of RCT concerns and their clinical relevance, including: socialization settings for relational competence, the ability to control and regulate the self, relationship styles, intimacy and negotiation, the use of practice exercises in prevention and treatment of pathology, appendices featuring the Relational Answers Questionnaire and other helpful tools. Relational Competence Theory both challenges and confirms much of what we know about the range of human relationships, and is important reading for researchers, scholars, and students in personality and social psychology, psychotherapy, and couple and family counseling.
  • Google Books
    Office of Applied Studies.
    Also available: Print – 1999
  • 2007
    edited by Alexander I. Agoulnik.
    Relaxin and related peptides in male reproduction / Alexander I. Agoulnik -- The vascular actions of relaxin / Arundhathi Jeyabalan ... [et al.] -- The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease / Chrishan S. Samuel, Edna D. Lekgabe, and Ishanee Mookerjee -- Relaxin-like ligand receptor systems: are autocrine/paracrine effectors in tumor cells and modulate cancer: progression and tissue invasiveness / Thomas Klonisch ... [et al.] -- Relaxin family peptide and receptor systems in brain: insights from recent anatomical and functional studies / Sherie Ma and Andrew L. Gundlach. The evolution of the relaxin peptide family and their receptors / Tracey N. Wilkinson and Ross A.D. Bathgate -- Relaxin, the relaxin-like factor and their receptors / Christian Schwabe and Erika E. Büllesbach -- Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone" / Richard Ivell, Kee Heng, and Ravinder Anand-Ivell -- Relaxin physiology in the female reproductive tract during pregnancy / Laura J. Parry and Lenka A. Vodstrcil --
  • 2012 Springer
    A. Ravishankar Rao, Guillermo A. Cecchi, editors.
    Introduction -- Adaptation and contraction theory for the synchronization of complex neural networks -- Temporal coding is not only about cooperation, it is also about competition -- Using non-oscillatory dynamics to disambiguate pattern mixtures -- Functional constraints on network topology via generalized sparse -- Evolution of time in neural networks, from the present to the past, and forward to the future -- Synchronization of coupled pulse-type hardware neuron models for CPG model -- A univesal abstract-time platform for real-time neural networks -- Solving complex control tasks via simple rule(s), using chaotic dynamics in a recurrent neural network model -- Time scale analysis of neuronal ensemble data used to feed neural network models -- Simultaneous EEG-fMRI, integrating spatial and temporal resolution -- Erratum to: Time scale analysis of neuronal ensemble data used to feed neural network models.
  • 2013
    William R. Uttal.
    "Cognitive neuroscientists increasingly claim that brain images generated by new brain imaging technologies reflect, correlate, or represent cognitive processes. In this book, William Uttal warns against these claims, arguing that, despite its utility in anatomic and physiological applications, brain imaging research has not provided consistent evidence for correlation with cognition. Uttal bases his argument on an extensive review of the empirical literature, pointing to variability in data not only among subjects within individual experiments but also in the new meta-analytical approach that pools data from different experiments. This inconsistency of results, he argues, has profound implications for the field, suggesting that cognitive neuroscientists have not yet proven their interpretations of the relation between brain activity captured by macroscopic imaging techniques and cognitive processes; what may have appeared to be correlations may have only been illusions of association. He supports the view that the true correlates are located at a much more microscopic level of analysis: the networks of neurons that make up the brain." -- [Publisher-supplied data]
  • 2008 CRCnetBASE
    B.S. Dhillon.
    Basic mathematical concepts -- Introduction to reliability technology, human error, and quality -- Medical device safety and quality assurance -- Medical device software quality assurance and risk assessment -- Medical device maintenance and sources for obtaining medical device-related failure data -- Human error in health care -- Health care human error reporting systems and models for predicting human reliability and error in health care -- Patient safety -- Introduction to quality in health care -- Quality methods for use in health care.
  • 2011 NAP
    Committee on Advancing Pain Research, Care, and Education, Board on Health Sciences Policy, Institute of Medicine of the National Academies.
    1. Introduction -- 2. Pain as a Public Health Challenge -- 3. Care of People with Pain -- 4. Education Challenges -- 5. Research Challenges -- 6. A Blueprint for Transforming Pain Prevention, Care, Education, and Research -- Glossary -- A. Data Sources and Methods -- B. Summary of Written Public Testimony -- C. The Economic Costs of Pain in the United States -- D. Committee and Staff Biographies.
  • 2014 Springer
    Adina Kalet, Calvin L. Chou, editors.
    Defining and Assessing Competence -- An Example of a Remediation Program -- 'She Needs to Read More': Helping trainees who struggle with medical knowledge -- Remediation of Interpersonal and Communication Skills -- Remediation of Physical Exam Skills -- Assessing and Remediating Clinical Reasoning -- Remediating Lapses in Professionalism -- 'You said, I heard': Speaking the subtext in interracial conversations -- Learning Differences and Medical Education -- 'Well, This Is Awkward': Autism Spectrum Disorder in Medical Trainees -- Stress and Distress and Wellness -- Perspectives from a Psychiatrist in an Office of Advising Resources -- The Metacognitive Competency: The key to life-long learning -- Use of Reflection as a Remediation Tool -- Feedback -- Appreciative Coaching: A positive process for remediation -- Preparing Program Directors to Address Unprofessional Behavior -- The View from the Dean's Office -- Preparing to Conduct Remediation -- 'The Prognosis is Poor': When to give up -- A Research Agenda for the Field of Remediation -- Epilogue: A Student's Perspective on Remediation.
  • 2016 ClinicalKey
    [edited by] Christopher B. Wilson, Victor Nizet, Yvonne A. Maldonado, Jack S. Remington, Jerome O. Klein.
    Also available: Print – 2016
  • 2008
    Deveroux Ferguson.
    Status: Not Checked OutLane Catalog Record
  • 2006
    John Henderson.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    John A. Libertino, editor.
    Epidemiology, Screening, and Clinical Staging / Michael J. Lipsky, Christopher M. Deibert -- Molecular Biology and Genetics / Jeff Klomp, Karl Dykema, Bin Tean Teh, Kyle Furge -- Familial and Hereditary Syndromes / Brian Shuch, Peter Pinto -- Pathology of Renal Cell Carcinoma / Fang-Ming Deng, Jonathan Melamed, Ming Zhou -- Imaging of Renal Cancer / Jalil Afnan, Christoph Wald -- Molecular Imaging for Renal Cell Carcinoma / Jian Q. Yu, Yamin Dou -- History of Renal Surgery for Cancer / Kamal Nagpal, Karim Hamawy -- Natural History, Role of Biopsy, and Active Surveillance of Renal Masses / Anthony T. Corcoran, Marc C. Smaldone, Robert G. Uzzo -- Interventional Radiology and Angioinfarction: Transcatheter Embolization of Renal Tumors / Sebastian Flacke, Shams Iqbal -- Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma / Patrick A. Kenney, Christopher G. Wood -- Rationale for Partial Nephrectomy / Nicholas Donin, William Huang -- Objectifying Complexity of Kidney Cancers: Relationships of Tumor Anatomy and Outcomes / Serge Ginzburg, Alexander Kutikov, Robert G. Uzzo -- Open Partial Nephrectomy / Patrick A. Kenney, Matthew F. Wszolek, John A. Libertino -- Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses / Casey G. Kowalik, David Canes, Ali Moinzadeh -- Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava / Chad Wotkowicz, John A. Libertino -- Role of Lymphadenectomy / Prof. Dr. Hein Van Poppel -- Postoperative Surveillance Protocols for Renal Cell Carcinoma / Megan M. Merrill., Jose A. Karam -- Role of Surgery in Locally Recurrent and Metastatic Renal Cancer / Paul Russo -- Outcomes: Prognostic Factors, Models, and Algorithms / Brandon K. Isariyawongse, Michael W. Kattan -- Adjuvant Systemic Therapy, Immunotherapy, and Targeted Treatment / Linda Cerbone, Cora N. Sternberg -- Role for Radiation Therapy in Renal Cancer / Andrea McKee, Arul Mahadevan, Timothy Walsh -- Surgical Management for Transitional Cell Carcinoma of the Upper Tract / Jason R. Gee -- Management of Non-clear Cell Renal Cell Carcinoma / Henry J. Conter, Jose A. Karam, Nizar M. Tannir.
  • 2008 Springer
    Jean J.M.C.H. de la Rosette, Cora N. Sternberg, and Hein P.A. van Poppel (eds.).
  • 2013 Springer
    Steven C. Campbell, Brian I. Rini, editors.
    Part 1. Localized Disease -- Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors / Frédéric D. Birkhäuser, Nils Kroeger and Allan J. Pantuck -- Pathology of Renal Cell Carcinoma / Ming Zhou and Huiying He -- Familial Renal Cell Carcinoma / Simon P. Kim and Bradley C. Leibovich -- Imaging of Renal Cell Carcinoma / Andrei S. Purysko, Erick M. Remer and Brian R. Herts -- Prognostic Factors for Localized Renal Cell Carcinoma / Brian R. Lane -- Part 2. Management of Localized RCC -- Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass Biopsy / Matthew N. Simmons and Steven C. Campbell -- Radical Nephrectomy for Localized Renal Tumors: Optimum Oncological and Renal Functional Considerations / Paul Russo -- Nephron-Sparing Surgery for Renal Cancer / Alon Z. Weizer, Jeffery S. Montgomery and Khaled S. Hafez -- Thermal Ablation / Surena F. Matin and Kamran Ahrar -- Active Surveillance of the Small Renal Mass / Marc C. Smaldone, Daniel Canter, Alexander Kutikov and Robert G. Uzzo -- Part 3. Locally Advanced Disease -- Locally Advanced Renal Cell Carcinoma / Stephen H. Culp and Christopher G. Wood -- Neoadjuvant Targeted Therapy and Consolidative Surgery / Sean P. Stroup and Ithaar H. Derweesh -- Part 4. Advanced Disease -- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects) / Alexandra Arreola and W. Kimryn Rathmell -- Prognostic Factors in Advanced Renal Cell Carcinoma / Michael M. Vickers and Daniel Y. C. Heng -- Integration of Surgery in Metastatic Renal Cancer / Tom Powles and Axel Bex -- Immunotherapy for Renal Cell Carcinoma / Diwakar Davar, Moon Fenton and Leonard J. Appleman -- Targeted Therapy: Vascular Endothelial Growth Factor / Linda Cerbone and Cora N. Sternberg -- Mammalian Target of Rapamycin in Renal Cell Carcinoma / Eric Jonasch and Michel Choueiri -- Palliative and Supportive Care for Renal Cancer / Armida Parala-Metz and Mellar Davis.
  • 2009 Springer
    Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
    Targeted therapy for metastatic renal call carcinoma: overview -- Molecular genetics in inherited renal cell carcinoma: identification of targets in the hereditary syndromes -- Molecular targets in renal tumors: pathologic assessment -- Interferons and interleukin-2: molecular basis of activity and therapeutic results -- The molecular biology of kidney cancer and its clinical translation into treatment strategies -- VEGF: biologic aspects and clinical approaches -- VEGF and PDGF receptors: biologic relevance and clinical approaches to inhibition -- Sunitinib and axitinib in renal cell carcinoma -- Sorafenib in renal cell carcinoma -- Additional tyrosine kinase inhibitors in renal cell carcinoma -- Integrin [alpha]5[beta]1 as a novel therapeutic target in renal cancer -- Carbonic anhydrase IX: biology and clinical approaches -- Monoclonal antibody G250 recognizing carbonic anhydrase IX in renal cell carcinoma: biological and clinical studies -- Chemokines in renal cell carcinoma: implications for tumor angiogenesis and metastasis -- P13K/Akt/mTOR pathway: a growth and proliferation pathway -- EGFR and HER2: relevance in renal cell carcinoma -- Proteasome-NF[kappa]B signaling pathway: relevance in RCC -- The role of hepatocyte growth factor pathway signaling in renal cell carcinoma -- Smac/DIABLO: a proapoptotic molecular target in renal cell cancer -- EphA2: a novel target in renal cell carcinoma -- Restoring host antitumoral immunity: how coregulatory molecules are changing the approach to the management of renal cell carcinoma -- The role of gangliosides in renal cell carcinoma -- Tumour necrosis factor: misnomer and therapeutic target -- Molecular markers for predicting prognosis of renal cell carcinoma -- Adjuvant therapy for renal cell carcinoma: targeted approaches.
  • 2015 Springer
    Ronald M. Bukowski, Robert A. Figlin, Robert J. Motzer, editors.
  • 2012 Springer
    Robert A. Figlin, W. Kimryn Rathmell, Brian I. Rini, editors.
    Pt. 1. Biology of renal cell carcinoma -- pt. 2. Current and future molecular targets for RCC.
  • 2015 Springer
    Richard R. Heuser, Markus Schlaich, Horst Sievert, editors.
    This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.
  • 2014 ScienceDirect
    edited by Kevin W. Finkel, Scott C. Howard.
    Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.
  • 2008 Springer
    Sara Blakeley (ed.).
    Assessment of Renal Function / Mohan Arkanath -- Imaging of Acute Renal Failure - A Problem-Solving Approach for Intensive Care Unit Physicians / Tom Sutherland -- Drug-Induced Renal Injury / Sara Blakeley -- Acute Kidney Injury / Sara Blakeley -- Medical Management of Acute Renal Failure / Nerina Harley -- Acute Renal Failure in the Surgical Patient / Marlies Ostermann -- Rhabdomyolysis and Compartment Syndrome / Laurie Tomlinson and Stephen Holt -- Multisystem Causes of Acute Renal Failure / Tim Leach -- Therapeutic Plasma Exchange / Tim Leach -- Renal Replacement Therapy / John H. Reeves -- Technical Aspects of Renal Replacement Therapy / Sara Blakeley -- End-Stage Renal Disease / Emile Mohammed -- Clinical Hyperkalemia and Hypokalemia / Harn-Yih Ong -- Clinical Hyponatremia and Hypernatremia / Himangsu Gangopadhyay -- Clinical Metabolic Acidosis and Alkalosis / Sara Blakeley.
  • 2014 Springer
    Tatjana Antic, Jerome B. Taxy.
    Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
  • 2014
    Helmut G. Rennke, M.D., professor of pathology, Harvard Medical School and Harvard-MIT Division of Health Sciences and Technology, Department of Pathology, Brigham & Women's Hospital, Boston, Massachusetts, Bradley M. Denker, M.D., associate professor of medicine, Harvard Medical School, Renal Division, Department of Medicine, Beth Israel Deaconess Medical Center, chief of nephrology, Harvard-Vanguard Medical Associates, Boston, Massachusetts.
    Status: Not Checked OutLane Catalog Record
    This text offers medical students a case-based approach to learning the mechanisms of renal disease. Each chapter covers a disease, beginning with a patient case and followed by a discussion of the pathophysiology of the disease. Issues of differential diagnosis and therapy are linked to pathophysiologic mechanisms. Short questions interspersed throughout the text require students to apply their knowledge. Detailed answers to the questions are included. New to this edition: Full-color artwork and design. New color photomicrographs of clinical conditions. Additional end-of-chapter summaries. Up-to-date information based on new medical findings.
  • 2007
    Helmut G. Rennke, Bradley M. Denker.
    Status: Not Checked OutLane Catalog Record
    Review of renal physiology -- Regulation of salt and water balance -- Disorders of water balance : hyponatremia, hypernatremia, and polyuria -- Edematous states and the use of diuretics -- Acid-base physiology and metabolic alkalosis -- Metabolic acidosis -- Disorders of potassium balance -- Urinalysis and approach to the patient with renal disease -- Pathogenesis of major glomerular and vascular diseases -- Progression of chronic renal failure -- Acute renal failure -- Signs and symptoms of chronic renal failure -- Tubulointerstitial diseases.
  • 2013 Springer
    Larry K. Golightly, Isaac Teitelbaum, Tyree H. Kiser, Dimitriy A. Levin, Gerard R. Barber, Michael A. Jones, Nancy M. Stolpman, Katherine S. Lundin, editors.
    As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes.This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
  • 2013 ClinicalKey
    Bruce M. Koeppen, Bruce A. Stanton.
    Physiology of body fluids -- Structure and function of the kidneys -- Glomerular filtration and renal blood flow -- Renal transport mechanisms: NaCI and water reabsorption along the nephron -- Regulation of body fluid osmolality: regulation of water balance -- Regulation of extracellular fluid volume and NaCI balance -- Regulation of potassium balance -- Regulation of acid-base balance -- Regulation of calcium and phosphate homeostasis -- Physiology of diuretic action -- App. A: Integrative case studies -- App. B: Normal laboratory values -- App. C: Nephron function -- App. D: Answers to self-study problems -- App. E: Answers to integrative case studies -- App. F: Review examination.
  • 2007
    edited by Bruce M. Koeppen, Bruce A. Stanton.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Kathy Pritchard-Jones, Jeffrey S. Dome, editors.
    This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
  • 2014 Springer
    Lilach O. Lerman, Stephen C. Textor, editors.
    This book describes the recent advances in the understanding of the development and management of renal vascular disease (RVD). Current perspectives regarding the epidemiology of atherosclerotic RVD, its clinical manifestations, and the interaction with injury pathways related to the kidney have evolved considerably, and the widespread introduction of non-invasive methods for identification of RVD using ultrasound, CT, and MR imaging has allowed more facile identification of these diseases than ever before. Renal Vascular Disease provides an accessible, up-to-date summary of the pathophysiology and management of RVD. The clinical paradigms that are emerging in the field, both in regards to RVD and its role in chronic kidney disease (CKD), cardiovascular risk, and the cardiorenal syndromes are discussed in this comprehensive text, making it an essential resource for clinicians and investigators who tackle the challenges of RVD.
  • 2009 Springer
    Walmor C. DeMello, Edward D. Frohlich, editors.
    Systemic versus local renin angiotensin systems: An overview / W.C. DeMello and R.N. Re -- Clinical import of the local renin angiotensin aldosterone systems / E.D. Frohlich -- Renin, prorenin, and the (pro)renin receptor / G. Nguyen and A. Contrepas -- Local renin angiotensin systems in the cardiovascular system / R.N. Re -- Renin-angiotensin-aldosterone system and pathobiology of hypertension / P. Paradis and E.L. Schiffrin -- AT{subscript]1 receptors, angiotensin receptor blockade, and clinical hypertensive disease / R.M. Carey -- Structural and electrophysiological remodeling of the failing heart / W.C. DeMello -- Inhibiting the renin angiotensin aldosterone system in patients with heart failure and myocardial infarction / M.A. Pfeffer -- Left ventricular hypertrophy and treatment with renin angiotensin system inhibition / E.D. Frohlich and J. Díez -- Angiotensin-(1-7), angiotensin-converting enzyme 2, and new components of the renin angiotensin system / A.J. Trask ... [et al.] -- Kinin receptors and ACE inhibitors: An interrelationship / E.G. Erdös, F. Tan and R.A. Skidgel -- Kinins and cardiovascular disease / O.A. Carretero, X.-P. Yang and N.-E. Rhaleb -- CMS and type 2 diabetes mellitus: Bound together by the renin angiotensin aldosterone system / D. Gupta ... [et al.] -- Renin angiotensin aldosterone system and cardiovascular disease / S. Bernard ... [et al.] -- Renin angiotensin system and atherosclerosis / C. Hu and J.L. Mehta -- Renin angiotensin system and aging / L.F. Ferder.
  • 2010 Springer
    Po Sing Leung.
    Overview of the pancreas -- Physiology of the pancreas -- Common pancreatic disease -- Circulating RAS -- Local RAS -- Pancreatic RAS -- Basic techniques for pancreatic research -- Current research of the RAS in diabetes mellitus -- Current research concerning the RAS in pancreatic stem cells -- Current research of the RAS in pancreatitis and pancreatic cancer.
    Also available: Print – 2010
  • 2012 ClinicalKey
    editor, Janet M. Rennie.
    Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods of diagnosis and treatment. This 5th edition represents the state-of-the-art on neonatal care, providing not only detailed pathophysiology and clinical chapters on every condition of the neonate but also comprehensive chapters on the psychosocial aspects of neonatology, such as handling perinatal death and ethical and legal aspects of neonatal care. Contributions from Fetal Medicine experts and Obstetricians provide valuable peripheral information essential to the practice of neonatology. This book is the gold standard for neonatal care and will be an invaluable tool for everyone involved in the care of the neonate. It serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal certification exams, and a useful resource for the entire neonatal care team.
  • Google Books
    Perlmann, Alfred.
    Also available: Print – v. 1, 1914.
  • 2006
    prepared for Agency for Healthcare Research and Quality ; prepared by Abt Associates Inc., Andrea Hassol, Project Director and Co-Investigator, Partners Healthcare System, Richard Zane.
    Provides tools to assist emergency planners in evaluating the feasibility of, and requirements for, reopening shuttered hospitals in their local communities to expand surge capacity during a mass casualty event
  • 2012 Springer
    Scott F.M. Duncan, editor.
    Reoperative Hand Surgery is a major contribution to the literature, offering a wide range of reoperative options for challenging problems that face the reconstructive hand surgeon after failed primary surgery. Concise and discussing all of the more common issues that hand surgeons often face in performing revision surgery, this invaluable title is unique in that it looks specifically at the problem of what to do when the original index procedure did not go as planned. Topics covered include the hand, wrist, forearm and elbow, and several sections of the book discuss some of the psychological and social factors that also go into the decision process to reoperate or not. The chapters are tightly focused so that the important aspects to consider for reoperation can be quickly reviewed. There is also a component that discusses how to avoid other pitfalls and to minimize as well as manage any complications that may occur with reoperative procedures. Importantly, the book is replete with original art work to help describe and demonstrate how to perform many reoperative procedures. The artwork is simple and straightforward but yet detailed enough to convey the important steps and aspects for the surgical intervention it is outlining. Developed by renowned experts in the hand surgery field, Reoperative Hand Surgery is an indispensable, state-of-the-art reference, offering the busy hand and upper extremity surgeon easily accessible information relating to the evaluation, diagnosis, and possible surgical interventions for the diagnoses discussed.
  • 2008 Springer
    edited by Steven Teich, Donna A. Caniano.
  • 2009 Springer
    edited by Richard P. Billingham, Kathleen Kobashi, William Peters.
  • 2006 Springer
    Polly Roy (ed.).
    Attachment and cell entry of mammalian orthoreovirus / K.M. Guglielmi ... [et al.] -- Early steps in rotavirus cell entry / S. Lopez and C.F. Arias -- Early steps in avian reovirus morphogenesis / J. Benavente and J. Martinez-Costas -- Bluetongue virus assembly and morphogenesis / P. Roy and R. Noad -- Reovirus structure and morphogenesis / K.M. Coombs -- Rotavirus genome replication and morphogenesis : role of the viroplasm / J.T. Patton ... [et al.] -- Rotavirus proteins : structure and assembly / J.B. Pesavento ... [et al.] --- Structural studies on orbivirus proteins and particles / D.I. Stuart and J.M. Grimes -- Rotavirus assembly : an alternative model that utilizes and atypical trafficking pathway / S. Chwetzoff and G. Trugnan.
    Also available: Print – 2006
  • 2006 Springer
    edited by William R. Walsh.
    Tendon repair and regeneration: an overview / Eric M. Bluman, Scott D. Allen, Paul D. Fadale -- Structure and function of ligaments, tendons, and joint capsule / Frederick H. Silver, Joseph W. Freeman, Gino Bradica -- Tendons of the hand: anatomy, repair, healing, and rehabilitation / Paul C. Stephens ... [et al.] -- Evolution of concepts in flexor tendon surgery of the hand / Randip R. Bindra -- Basic science of the shoulder ligaments / Louis J. Soslowsky and Jeffrey S. Cartmell -- History of cruciate ligaments: development of repair and reconstruction / Jon Karlsson -- Rotator cuff / Richard O. Evans, Peter J. Hughes, David H. Sonnabend -- Frozen shoulder / Peter J. Hughes, Richard O. Evans, Jerome A. Goldberg -- Capsular shrinkage of the shoulder: current clinical status / Andrew L. Wallace -- Biomechanical and clinical evaluation of tendons and ligaments / David Hartright ... [et al.] -- Healing of ligament and tendon to bone / Andreas Weiler, Sven Scheffler, Maria Apreleva -- Artificial ligaments / Andrew A. Amis -- Tendon and ligament fixation to bone / Christopher M. Hill, Yuehuei H. An, Frank A. Young -- Tissue engineering strategies for regeneration of the anterior cruciate ligament / Michael G. Dunn -- Gene therapy and ligament healing / Norimasa Nakamura.
  • v. 1-5, 1959-61.
    Martini Aldo e Martini Paolo collaboratori, Rivosecchi Vittorio, Balestra Ester.
    Status: Not Checked OutLane Catalog Record
  • 2012 Karger
    volume editor, Manuel A. Garrido-Ramos.
    The Repetitive DNA Content of Eukaryotic Genomes / López-Flores, I.; Garrido-Ramos, M.A. -- Telomere Dynamics in Mammals / Silvestre, D.C.; Londoño-Vallejo, A. -- Drosophila Telomeres: an Example of Co-Evolution with Transposable Elements / Silva-Sousa, R.; López-Panadès, E.; Casacuberta, E. -- The Evolutionary Dynamics of Transposable Elements in Eukaryote Genomes / Tollis, M.; Boissinot, S. -- SINEs as Driving Forces in Genome Evolution / Schmitz, J. -- Unstable Microsatellite Repeats Facilitate Rapid Evolution of Coding and Regulatory Sequences / Jansen, A.; Gemayel, R.; Verstrepen, K.J. -- Satellite DNA Evolution / Plohl, M.; Meštrović, N.; Mravinac, B. -- Satellite DNA-Mediated Effects on Genome Regulation / Pezer, Ž.; Brajković, J.; Feliciello, I.; Ugarković, Đ. -- The Birth-and-Death Evolution of Multigene Families Revisited / Eirín-López, J.M.; Rebordinos, L.; Rooney, A.P.; Rozas, J. -- Chromosomal Distribution and Evolution of Repetitive DNAs in Fish / Cioffi, M.B.; Bertollo, L.A.C..
  • 2013 Springer
    Paul B Fitzgerald, Z. Jeff Daskalakis.
    Repetitive transcranial magnetic stimulation (rTMS) treatment is increasingly being used in the management of patients with depression. Since the approval of one rTMS device in the United States in 2008, clinical services using this equipment have become relatively common there, and services are also being developed in a variety of other countries. However, considerable ignorance exists about the treatment in general psychiatric practice. This concise clinical guide will serve as a reference and practical tool for clinicians working with or learning about this treatment technique. The opening chapters provide basic information on the history and development of rTMS treatment and its mechanism of action. Use of the treatment in depression is then addressed in detail, with explanation of the evidence base and discussion of clinical issues such as selection of patients and type of treatment, dose, and treatment duration. Side-effects of treatment are explored, and careful consideration is given to various practical issues concerning the establishment of rTMS treatment programs and the training of clinicians. The final chapters will provides a brief overview of potential rTMS applications in other psychiatric conditions and some background on the use of related treatments, such as transcranial direct current stimulation.
  • 2011 Springer
    Philip R. Dormitzer, Christian W. Mandl, Rino Rappuoli, editors.
    Live vaccines and their role in modern vaccinology / Gordon Dougan, David Goulding, and Lindsay J. Hall -- Live attenuated vaccines : influenza, rotavirus and varicella zoster virus / Harry B. Greenberg and Ann M. Arvin -- Classical live viral vaccines / Thomas P. Monath -- Recombinant live vaccines to protect against the severe acute respiratory syndrome coronavirus / Luis Enjuanes ... [et al.] -- Live-attenuated Shigella vaccines. Is encouraging good enough? / Yves Germani and Philippe J. Sansonetti -- New generation BCG vaccines / Michael V. Tullius and Marcus A. Horwitz -- Basic science paves the way to novel safe and effective pestivirus vaccines / Norbert Tautz and Gregor Meyers -- Live attenuated influenza virus vaccines : NS1 truncation as an approach to virus attenuation / Natalie Pica, Peter Palese, and John Steel -- An attenuated HSV-1 live virus vaccine candidate that is replication competent bu defective in epithelial cell-to-cell and neuronal spread / Elizabeth E. Zumbrun and Harvey M. Frieman -- Live attenuated vaccines for respiratory syncytial virus / Michael N. Teng -- Live attenuated cholera vaccines : flagella and reactogenicity / D. Ewen Cameron and John J. Mekalanos -- Replication-defective herpes simplex virus mutant strains as genital herpes vaccines and vaccine vectors / David M. Knipe -- Nucleic acid-based infections and pseudo-infectious flavivirus vaccines / Justin A. Roby, Roy A. Hall, and Alexander A. Khromykh -- Application of cleavage activation mutants of influenza virus as live vaccines / Juergen Stech and Hans-Dieter Klenk -- Alphavirus particle-based vaccine vectors / Scott J. Balsitis, Clayton W. Beard, and Peter W. Mason -- Recombinant chimeric, live attenuated vaccines against flaviviruses and alphaviruses / Thomas P. Monath.
  • v. 1-3, 1967-. Google Books
    Fulltext (v. 2) Google Books
    Fulltext (v. 2) Google Books
    Also available: Print – v. 1-3, 1967-.
  • v. 1, 1940.
    Status: Not Checked OutLane Catalog Record
  • Silverchair
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Also available: Print – 1970-<2012>
  • v. 1-2, 1994. NIH
    Human Embryo Research Panel.
    Volume 2 has country-by-country analysis.
  • 1973-
    v. 1. Results of the initial evaluation phase.
  • 2011 WHO
    The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
    Also available: Print – 2011
  • v. 1-<8>, 1985-<1986> Google Books
    v. 1. Executive summary -- v. 2. Crosscutting issues in minority health -- v. 3. Cancer -- v. 4. Cardiovascular and cerebrovascular disease 2 v. -- v. 5. Homicide, suicide, and unintentional injuries -- v. 6. Infant mortality and low birthweight -- v. 7. Chemical dependency and diabetes -- v. 8. Hispanic health issues/Inventory of DHHS programs/Survey of non-federal community.
  • The report includes listings of substances, divided into two categories: known human carcinogens and substances reasonably anticipated to be human carcinogens.
  • NLM
    Submitted by William H. Stewart, surgeon general, Public Health Service.
    Also available: Print – 1967
  • vol. 1-2=, 2015
  • 2006
    Status: Not Checked OutLane Catalog Record
  • 2007
    Status: Not Checked OutLane Catalog Record
  • 2007 Springer Protocols
    edited by Donald S. Anson.
    Methodologies for staining and visualization of [beta]-galactosidase in mouse embryos and tissues / Siobhan Loughna and Deborah Henderson -- Immunohistochemical detection of [beta]-galactosidase or green fluorescent protein on tissue sections / Philip A. Seymour and Maike Sander -- Detection of reporter gene expression in murine airways / Maria Limberis, Peter Bell, and James M. Wilson -- Three-dimensional analysis of molecular signals with episcopic imaging techniques / Wolfgang J. Weninger and Timothy J. Mohun -- Fluorescent proteins for cell biology / George H. Patterson -- Detection of GFP during nervous system development in Drosophila melanogaster / Karin Edoff, James S. Dods, and Andrea H. Brand -- Autofluorescent proteins for flow cytometry / Charles G. Bailey and John E. J. Rasko -- Fluorescent protein reporter systems for single-cell measurements / Steven K. Dower, Eva E. Qwarnstrom, and Endre Kiss-Toth -- Subcellular imaging of cancer cells in live mice / Robert M. Hoffman -- Noninvasive imaging of molecular events with bioluminescent reporter genes in living subjects / Pritha Ray and Sanjiv Sam Gambhir -- Green fluorescent protein as a tracer in chimeric tissues : the power of vapor fixation / Harald Jockusch and Daniel Eberhard.
  • 1919
    I. Reports of the Special Committee upon the manufacture, biological testing, and clinical administration of salvarsan and of its substitutes -- II. Toxic effects following the employment of arsenobenzol preparations.
  • 2007 Springer
    S. Funahashi (ed.).
  • 2013 IngentaConnect
    Yolanda Eraso.
    Introduction -- Part I. The medical record: 1. Mothers and the first medical concerns -- 2. Towards a taxonomy of maternal bodies: biotypology, eugenics and Argentine nationalism (1930-1946) -- Part II. The textual record: 3. The Catholic press and the strategic uses of the Marian cult -- 4. The liberal press and the political uses of the maternal -- 5. Fictionalised mothers: absence, fear, and rebellion in literary representations -- Part III. The visual record: 6. Photojournalism and the question of maternal visualisation before the technologies of visualisation -- 7. The subjectivity of the mother according to the artistic gaze -- Epilogue.
    Also available: Print – 2013
  • 2006 Springer
    edited by Larissa Swedell and Steven R. Leigh.
    Perspectives on reproduction and life history in baboons / Larissa Swedell & Steven R. Leigh -- Infant mortality, paternity certainty, and female reproductive strategies in hamadryas baboons / Larissa Swedell & Julian Saunders -- Female behavioral strategies of hybrid baboons in the Awash National Park, Ethiopia / Jacinta C. Beehner & Thore J. Bergman -- Hybrid baboons and the origins of the hamadryas male reproductive strategy / Thore J. Bergman -- The social and ecological flexibility of Guinea baboons : implications for Guinea baboon social organization and male strategies / Anh Galat-Luong, Gérard Galat & Suzanne Hagell -- Social organization, reproductive systems, and mediation of baboon endogenous virus (BaEV) copy number in gelada, hamadryas, and other Papio baboons / Monica Uddin, Jane E. Phillips-Conroy & Clifford J. Jolly -- Reproduction, mortality, and female reproductive success in chacma baboons of the Okavango Delta, Botswana / Dorothy L. Cheney ... [et al.] -- Maternal characteristics and offspring growth in chacma baboons : a life-history perspective / Sara E. Johnson -- Whose life is it anyway? Maternal investment, developmental trajectories, and life history strategies in baboons / Louise Barrett, S. Peter Henzi & John E. Lycett -- Ontogeny, life history, and maternal investment in baboons / Steven R. Leigh & Robin M. Bernstein -- Testicular size, developmental trajectories, and male life history strategies in four baboon taxa / Clifford J. Jolly & Jane E. Phillips-Conroy -- The evolutionary past and the research future : environmental variation and life history flexibility in a primate lineage / Susan C. Alberts & Jeanne Altmann.
  • bk. 4-5, 1972.
    edited by C. R. Austin and R. V. Short ; illus. by John R. Fuller.
    Status: Not Checked OutLane Catalog Record
    v. 1. Germ cells and fertilization.--v. 2. Embryonic and fetal development.--v. 3. Hormones in reproduction.--v. 4. Reproductive patterns.--v. 5. Artificial control of reproduction.--Book 6. The evolution of reproduction. --Book 8. Human sexuality.
  • 2011 ScienceDirect
    edited by Ramesh Gupta.
    Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • 2006 ScienceDirect
    edited by Michael Lockshin and D. Ware Branch.
  • 2009 Springer
    Pedro J. Chedrese, editor.
    Basis for molecular reproductive biology -- Introduction to the molecular organization of the endocrine/reproductive system -- Extracellular signaling receptors -- Molecules that transmit information into the cell: the intracellular signaling pathways -- Introduction to molecular biology: structure and function of the macromolecules of genetic information -- Regulation of gene expression -- Molecular basis of abnormal phenotype -- Tools of molecular reproductive biology -- Recombinant DNA technology -- Techniques for DNA analysis -- Analyzing gene expression -- DNA microarray analysis -- Computer assisted analysis of genes -- Introduction to gene therapy -- Molecular regulation of reproductive hormones -- GnRH-GnRH-receptor system in the mammalian female reproductive tract -- FSH: one hormone with multiple forms, or a family of multiple hormones -- FSH receptor: one receptor with multiple forms or a family of receptors -- Regulation of the early steps in gonadal steroidogenesis -- Prostaglandins and their mechanisms of action in the cyclic ovary -- Androgens: molecular basis and related disorders -- Leptin as a reproductive hormone -- Neurosteroids and sexual behavior and reproduction -- Molecular regulation of the reproductive organs and tissues -- Autocrine and paracrine regulation of the ovary -- Ovarian endocrine activity: role of follistatin, activin, and inhibin -- Hormonal and molecular regualtion of the cytochrome P450 aromatase gene expression in the ovary -- Epigenetic mechanisms of ovarian gene regulation -- Ovarian function and failure: the role of the oocyte and its molecules -- Molecular control of corpus luteum function -- Molecular landscape of spermatogonial stem cell renewal, meiotic sex chromosome inactivation, and spermatic head shaping.
  • 2010 Springer
    Douglas T. Carrell, C. Matthew Peterson, eds.
    Characteristics of a successful R.E.I. clinic and laboratory -- Assisted reproductive technology practice management -- Collaboration within the reproductive endocrinology and infertility practice: integration of laboratory and clinic operations -- Informed consent in advanced reproductive technology -- Reproductive laboratory regulations, certifications and reporting systems -- Successfully integrating the FDA regulations into your practice -- Psychosocial consequences of infertility and treatment -- A live baby or your money back: the marketing of in vitro fertilization procedures -- Ovulation: a molecular view -- Clinical evaluation of female factor infertility -- Polycystic ovary syndrome -- The current status for Metformin use in reproductive medicine -- Clinical aspects of endometriosis -- Common endocrinopathies in reproductive endocrinology -- Acquired uterine factors and infertility -- Mullerian (paramesonephric) anomalies and associated Wolffian (mesonephric) duct malformations -- Recurrent miscarriage -- Laparoscopy in the diagnosis and treatment of female infertility -- Turner syndrome -- Errors in chromosome segregation during oogenesis and early embryogenesis -- An overview of sperm production -- Meiotic recombination and errors during spermatogenesis -- Clinical evaluation and treatment of male factor infertility -- Semen analysis: essentials for the clinician -- Sperm capacitation, the acrosome reaction, and fertilization -- Advanced tests of sperm function -- Genetic testing of male infertility Varicocele and male infertility -- Sperm retrieval techniques -- The clinical utility of the evaluation of sperm chromatin -- Artificial insemination: intrauterine insemination -- Sperm preparation for artificial insemination -- Sperm banking, donation, and transport in the age of assisted reproduction: federal and state regulation -- Reproductive treatment of HIV-1 discordant couples -- Ovulation induction -- Transvaginal sonography in reproductive endocrinology and infertility -- Establishing the IVF laboratory: a systems view -- Preparation and selection of sperm for IVF and ICSI -- The genetic and epigenetic contributions of sperm to early embryogenesis -- Micromanipulation of human oocytes and embryos: applications of intracytoplasmic sperm injection and assisted hatching in infertility treatment -- Embryo culture techniques -- In-vitro maturation of human oocytes -- Integrating preimplantation genetic diagnosis into the ART laboratory -- Evaluation and selection of preimplantation embryos for transfer -- Embryo transfer in IVF: evidence-based clinical practice -- Cryopreservation of human oocytes and embryos -- Preserving fertility -- Ovarian hyperstimulation syndrome -- Pregnancy outcomes in infertile couples -- The impact of complementary medicine on in-vitro fertilization -- Designing a clinical research infrastructure -- Integrating research into a clinical practice -- Research regulations: the role of the Institutional Review Board -- Technology transfer and its role in the practice of reproductive endocrinology and infertility -- The environment and reproduction: endocrine disruption, reproductive impairment, and epigenetics.
  • 2010
    Ray M. Merrill.
    Status: Not Checked OutLane Catalog Record
    Foundations of reproductive epidemiology -- Environments in reproductive epidemiology -- Research process in reproductive epidemiology -- Surveillance in reproductive epidemiology -- Descriptive reproductive health indicators -- Study designs in reproductive epidemiology -- Causal inference in reproductive epidemiology -- Nutrition and reproductive health -- Contraception and reproductive health -- Mercury, lead, environmental estrogens, and reproductive health -- Psychosocial factors and reproductive health -- Early childbearing : trends and consequences -- Cancer risk associated with early and late maternal age at first birth.
  • 2009 Cambridge
    edited by Sean Kehoe, Lyn Chitty, Tessa Homfray.
    Genetic aetiology of infertility / Amu Bashamboo, Celia Ravel and Ken McElreavy -- Disorders of sex development / Lin Lin and John C. Achermann -- Preimplantation genetic diagnosis : current practice and future possibilities / Alison Lashwood and Tarek El-Toukhy -- Ethical aspects of saviour siblings : procreative reasons and the treatment of children / Mark Sheehan -- Epigenetics, assisted reproductive technologies and growth restriction / Jennifer M. Frost [and others] -- Fetal stem cell surgery / Jennifer Ruam, Michael Ting and Nicholas Fisk -- Prenatal gene therapy / Khalil Abi-Nader and Anna David -- Ethical aspects of stem cell therapy and gene therapy / Søren Holm -- Fetal dysmorphology : the role of the geneticist in the fetal medicine unit in targeting diagnostic tests / Tessa Homfray -- Fetal karotyping : what should we be offering and how? / John Crolla -- Non-invasive prenatal diagnosis : the future of prenatal genetic diagnosis? / Lyn Chitty, Gail Norbury and Helen White -- Non-invasive prenatal diagnosis for fetal blood group status / Geoff Daniels [and others] -- Selective termination of pregnancy and preimplantation genetic diagnosis : some ethical issues in the interpretation of legal criteria / rosamund Scott -- Implementation and auditing of new genetics and tests : translating genetic tests into practice in the NHS / Rob Elles and Ian Frayling -- New advances in prenatal genetic testing : the parent perspective / Jane Fisher -- Informed consent : what should we be doing? / Jenny Hewison and Louise Bryant -- Consensus views arising from the 57th Study Group : reproductive genetics.
  • 2012 Springer
    Gwendolyn P. Quinn, Susan T. Vadaparampil, editors ; foreword by Brad Zebrack.
    Principles of cancer treatment: impact on reproduction -- Fertility preservation options for females -- Options for fertility preservation in men and boys with cancer -- Contraception and cancer treatment in young persons -- Sexual health during cancer treatment -- Unique reproductive concerns of young women with breast cancer -- Pregnancy and cancer -- Preimplantation genetic diagnosis for hereditary cancers -- Non-traditional family building planning -- Parenting with cancer I: developmental perspective, communication, and coping -- Parenting with cancer II: parenting at different stages of illness -- Pediatric oncology and reproductive health -- Institutional approaches to implementing fertility preservation for cancer patients -- Patient provider communication and reproductive health -- Fertility preservation in cancer patients: ethical considerations -- Legal issue and of assisted reproductive technologies.
    Also available: Print – 2012
  • 2007 Springer
    edited by P. Nicolopoulou-Stamati, L. Hens, and C.V. Howard.
    Introduction -- Environmental Impact on Reproductive Health, Recent Trends and Developments / P. Nicolopoulou-Stamati and N.J. Lelos. Section 1: The Link Between Reproductive Health and Environment. -- Epidemiological Studies on the Relationship between Semen Quality and Environmental Chemicals: Historic and Contemporary Compounds / R. Hauser and J.D. Meeker -- Environment and Fertility / P. Saldiva. Section 2: Reproductive Health Effects. -- Male Reproductive Status and its Relationship with Man-Made, Hormone-Disrupting Substances: Studies In Flanders, Belgium / W. Dhooge, F. Eertmans, A. Mahmoud, and F. Comhaire -- Potential Impact of the Environment on the Male Reproductive Function: The Example Of Cryptorchidism / E. Huyghe, R. Mieusset and P.F. Thonneau -- Advanced Glycation End Products in Polycystic Ovarian Syndrome / E. Diamanti-Kandarakis, C. Piperi, and P. Nicolopoulou-Stamati -- Oocytes and Ovarian Follicles as Targets of Endocrine Disrupters: Consequences for Reproductive Health / F. Gandolfi, T.A.L. Brevini, and F. Cillo. Section 3: Pollutants And Exposure. -- Non-Pesticide Endocrine Disrupters and Reproductive Health / S. Corsolini -- Medical Drugs Impairing Fertility / N. Pandiyan -- Impact of Air Pollution on Reproductive Health in Northern Bohemia / J. Rubes, S.G. Selevan, R.J. Sram, D.P. Evenson, and S.D. Perreault. Section 4: Policy Instruments And Issues. -- Pesticides as Endocrine Disrupters: Identification of Hazards for Female Reproductive Function / M. Rescia and A. Mantovani -- Assessment of Fertility and Other Health Impacts for Selected Pollutants in Flanders: Opportunities and Limitations / J. De Wit, A. Verspecht and L. Hens -- Problems in Assessing Low Dose Effects of Endocrine Disrupters / A. Gies -- Getting the Message Across - WWFs and ISDEs Perspectives on Communication Strategies to Reduce Exposures to Hazardous Chemicals / G. Lyons and P. Illig -- Environmental Ethics and Fertility in Early Cultures and The Industrial Age / A. Katsivelaki and C.E. Sekeris. Section 5: Regional Aspects. -- Reproductive Health Problems in the Greater Athens Area / D.A. Adamopoulos and E. Koukkou -- Environment and Reproductive Health in Bulgaria / S. Stoyanov and E. Terlemesian.
  • 2006
    Reproductive Health and Research, World Health Organization.
    Status: Not Checked OutLane Catalog Record
    About these guidelines -- Introduction -- Indicators-an overview in the context of global monitoring -- Generation, interpretation and analysis of the shortlisted national reproductive health indicators -- 1. Total fertility rate -- 2. Contraceptive prevalence -- 3. Maternal mortality ratio -- 4. Antenatal care coverage -- 5. Births attended by skilled health personnel -- 6. Availability of basic essential obstetric care -- 7. Availability of comprehensive essential obstetric care -- 8. Perinatal mortality rate -- 9. Prevalence of low birth weight -- 10. Prevalence of positive syphilis serology in pregnant women -- 11. Prevalence of anaemia in women -- 12. Percentage of obstetric and gynaecological admissions owing to abortion -- 13. Reported prevalence of women with genital mutilation -- 14. Prevalence of infertility in women -- 15. Reported incidence of urethritis in men -- 16. Prevalence of HIV infection in pregnant women -- 17. Knowledge of HIV-related preventive practices -- Annex 1. Millennium Development Goals and associated targets -- Annex 2. The selection criteria for the shortlist of indicators.
  • 2014 Springer
    William V. Holt, Janine L. Brown, Pierre Comizzoli, editors.
    Part 1. Introduction. Reproductive science as an essential component of conservation biology / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- "Mayday mayday mayday", the Millennium Ark is sinking? / Steven L. Monfort -- Part 2. The big picture: can species survive and adapt in a changing world? Climate change, extinction risks, and reproduction of terrestrial vertebrates / Cynthia Carey -- Impacts of endocrine disrupting chemicals on reproduction in wildlife / Emmelianna Kumar and William V. Holt -- The role of genomics in conservation and reproductive sciences / Warren E. Johnson and Klaus Koepfli -- The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction / Agustín F. Fernández, Estela García Toraño, Rocío González Urdinguio, Abel Gayo Lana, Ignacio Arnott Fernández, and Mario F. Fraga -- The black-footed ferret: on the brink of recovery? / Rachel M. Santymire, Travis M. Livieri, Heather Branvold-Faber, and Paul E. Marinari -- Comparative reproductive biology of elephants / Janine L. Brown -- The koala (Phascolarctos cinereus): a case study in the development of reproductive technology in a marsupial / Stephen D. Johnston and William V. Holt -- Reproduction and advances in reproductive studies in carnivores / Katarina Jewgenow and Nucharin Songsasen -- Methods to examine reproductive biology in free-ranging, fully-marine mammals / Janet M. Lanyon and Elizabeth A. Burgess -- Amphibian declines in the twenty-first century: why we need assisted reproductive technologies / John Clulow, Vance L. Trudeau, and Andrew J. Kouba -- The reality, use and potential for cryopreservation of coral reefs / Mary Hagedorn and Rebecca Spindler -- Recent advances and prospects in germplasm preservation of rare and endangered species / Pierre Comizzoli and William V. Holt -- Sperm DNA fragmentation and its role in wildlife conservation / Jaime Gosálvez, William V. Holt, and Stephen D. Johnston -- Somatic cells, stem cells, and induced pluripotent stem cells: how do they now contribute to conservation? / Gabriela F. Mastromonaco, L. Antonio González-Grajales, Melissa Filice, and Pierre Comizzoli -- Biosafety in embryos and semen cryopreservation, storage, management and transport / A. Bielanski -- Fertility control in wildlife: review of current status, including novel and future technologies / Deborah Garside, Ayman Gebril, Manal Alsaadi, and Valerie A. Ferro -- Cloning the mammoth: a complicated task or just a dream? / Pasqualino Loi, Joseph Saragusty, and Grazyna Ptak -- Conclusions: environmental change, wildlife conservation and reproduction / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- Index.
    Also available: Print – 2014
  • 2015 Springer
    Mostafa Metwally, Tin-Chiu Li, editors.
    This evidence-based book examines the role of reproductive surgery in the current age of IVF and in modern medical practice. The authors provide a detailed insight into surgical techniques and where such practices stand relative to other fertility treatments such as assisted conception techniques. Reproductive Surgery in Assisted Conception is a useful reference book for current practicing reproductive surgeons as well as those training in the field. It is also invaluable to other fertility practitioners wishing to gain more insight into how and when surgical intervention may be used as either a standalone fertility treatment or to improve success rates of other fertility treatments.
  • 2009 Springer
    Frida Simonstein, editor.
    Current status of assisted reproductive techniques (ART) / Ariel Revel -- The medicalization of reproduction : a 30 year retrospective / Søren Holm -- Conceiving a new right to procreate / Marleen Eijkholt -- 'Can't avoid it, can't afford it' : assisted reproduction in Israel and Bulgaria / Frida Simonstein and Ekaterina Balabanova -- Assisted reproduction in developing countries : the debate at a turning point / Effy Vayena -- Ethical and socio-cultural aspects that influence ART in Latin America / Ester Polak de Fried -- Women, work, and children : is there a solution? / Daniel Callahan -- Between fecklessness and selfishness : is there a biologically optimal time for motherhood? / Anna Smajdor -- Gendered futures : reproduction and production in women's lives / Harriet Bradley -- Is transferred parental responsibility legitimately enforceable? / Matti Häyry -- Reproduction, responsibility and rationality / Tom Buller -- Male or female we will create them : the ethics of sex selection for non-medical reasons / David Heyd -- Artificial reproductive technologies and the advent of the artificial womb / Frida Simonstein -- Human before sex : Ectogenesis as a way to equality / Tuija Takala -- The glass womb / Iain Brassington -- A survey of people's attitude towards the artificial womb and ectogenesis in Israel / Frida Simonstein and Michal Mashiach-Eizenberg.
  • 2013
    Jennifer Jean Brady.
    Reprogramming of somatic nuclei to a pluripotent state can be achieved by two approaches: somatic cell nuclear transfer (cloning) and transcription factor transduction to generate induced pluripotent stem cells (iPS). Early molecular events in reprogramming are not well understood, in large part due to the inefficiency of nuclear transfer and iPS generation. This inefficiency has led to the hypothesis that early reprogramming is a stochastic rather than a deterministic process. We hypothesized that iPS generation could be improved by the identification of early molecular events and pathways that may enhance reprogramming. In order to model reprogramming of fibroblasts towards pluripotency, we generated mouse embryonic stem cell X human fibroblast heterokaryons in which somatic cell pluripotency gene activation and promoter demethylation occurs rapidly and without cell division. We show that heterokaryon cell fusion based reprogramming is rapid and extensive, and that active DNA demethylation of the somatic OCT4 and NANOG promoters requires Activation Induced Deaminase. Heterokaryon bi-species RNA- Seq identified a role for a secreted factor which enhanced iPS generation and could replace constitutive viral expression of the reprogramming factor c-Myc. These data demonstrate that heterokaryons can serve as a discovery tool for novel reprogramming factors and that findings in cell fusion based reprogramming can inform early events in iPS generation. Mixed species heterokaryons are an attractive model system for investigating mechanisms of active DNA demethylation in the context of the mammalian genome and provide a viable approach for investigating early events in cellular reprogramming.
  • 2012 Springer
    Xiaoyuan Wang, Jian Chen, Peter J. Quinn, editors.
    "Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation."--Publisher's description.
  • 2012
    Thomas Scott Vierbuchen.
    Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. However, recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Similar methods can also convert human fibroblasts to functional iN cells, by forced expression of Ascl1, Brn2, Myt1l and NeuroD1. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
  • 2006 ScienceDirect
    edited by Aage R. Møller.
  • v. 1-6, 1967-78. Karger
  • 2005 Springer
    E. Ueno ... [et al.], eds.
  • 2010 WHO
    "This overview outlines the statutory background for WHO's research, identifies the milestones in health research over five decades, and discusses issues of both process and programs. This report also includes accounts of regional efforts in health research"--Publisher's description. African region; Eastern Mediterranean region; European region; South East Asia region; Western Pacific region; Pan American Health Organization
    Also available: Print – 2010
  • 2014 ebrary
    edited by Joyce M. Ray.
    It has become increasingly accepted that important digital data must be retained and shared in order to preserve and promote knowledge, advance research in and across all disciplines of scholarly endeavor, and maximize the return on investment of public funds. To meet this challenge, colleges and universities are adding data services to existing infrastructures by drawing on the expertise of information professionals who are already involved in the acquisition, management and preservation of data in their daily jobs. Data services include planning and implementing good data management practices, thereby increasing researchers' ability to compete for grant funding and ensuring that data collections with continuing value are preserved for reuse. This volume provides a framework to guide information professionals in academic libraries, presses, and data centers through the process of managing research data from the planning stages through the life of a grant project and beyond. It illustrates principles of good practice with use-case examples and illuminates promising data service models through case studies of innovative, successful projects and collaborations.
  • 2013 Cambridge
    [edited by] Gary L. Comstock.
    "Ordinarily, responsible conduct of research (RCR) 'training' consists of lectures accompanied by generic exercises on 'core' topics. Research Ethics takes a novel, philosophical approach to the RCR and the teaching of moral decision-making. Part I introduces egoism and explains that it is in the individuals own interest to avoid misconduct, fabrication of data, plagiarism and bias. Part II takes up contractualism and covers issues of authorship, peer review and responsible use of statistics. Part III introduces moral rights as the basis of informed consent, the use of humans in research, mentoring, intellectual property and conflicts of interests. Part IV uses two-level utilitarianism to explore the possibilities and limits of the experimental use of animals, duties to the environment and future generations, and the social responsibilities of researchers. This book replaces mind-numbing rote exercises with an adventure in moral imagination and is an essential guide for graduate students in all disciplines"-- Provided by publisher.
  • 2013 Springer
    Daron Smith, Dan Wood.
    Research in Clinical Practice is a neat, pocket-sized reference guide examining how to get the most from actively participating in research. Including how to begin, avoiding pitfalls, whom to approach and what questions to ask - all significant practicalities for conducting research in the reader's area of interest. Each reader will learn how to make the best use of such a valuable time. Written by two experienced surgeons, both of whom achieved post graduate research degrees, Research in Clinical Practice, is an essential tool for clinicians embarking on a research project as well as those who are new to supervising researchers.
  • 1979-
    editor : Roberta G. Simmons.
    Status: Not Checked OutLane Catalog Record
  • Springer, 2005
    Satoru Miyano, Jill Mesirov, Simon Kasif, Sorin Istrail, Pavel Pevzner, Michael Waterman (eds.).
  • Springer, 2007
    Terry Speed, Haiyan Huang (eds.).
  • 2008 Springer
    Martin Vingron, Limsoon Wong (eds.).
  • Springer, 2006
    Alberto Apostolico, Concettina Guerra, Sorin Istrail, Pavel Pevzner, Michael Waterman (eds.).
  • 1979-
    Editor: Richard M. Scheffler.
    Status: Not Checked OutLane Catalog Record
  • 2008 Stanf Univ
    Topics include self-Management, self-Efficacy, health Status, and some diabetes-specific scales.
  • 2013 ScienceDirect
    volume editor, Jim De Yoreo.
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.
  • 2013 Springer
    Theodore Eliades, editor ; foreword by T.M. Graber.
    The orthodontic literature includes many articles on basic science and engineering research techniques, but clinicians are typically unfamiliar with the principles underlying these techniques and may also lack the background knowledge required for a full appreciation of their role. This book comprehensively reviews a wide array of the research methods most frequently encountered in the literature, encompassing the areas of materials science and clinical and biological research. The various methods and techniques are carefully described, and their indications and limitations are explained. All of the information is up to date, reflecting latest developments.For practicing professionals, Research Methods in Orthodontics will be an ideal introduction to instrumental analysis and basic science research methods in the field. It will also serve as an excellent reference guide for researchers. By familiarizing orthodontists with the basics of research methods, the book will boost their ability to keep pace with developments in treatment approaches, materials, and techniques and assist in the transfer of relevant future findings into practice.
  • 2007
    [edited by] Julia M. Addington-Hall, Eduardo Bruera, Irene J. Higginson, Sheila Payne.
    Status: Not Checked OutLane Catalog Record
    Ethical and practice issues in qualitative research / Frances Sheldon and Anita Sargeant -- Evaluating qualitative research / Michelle Crossley -- Mixed methods for evaluation research / Christine Ingleton and Sue Davies -- Ethnography / Jane Seymour -- Documentary analysis and policy / Margaret O'Connor -- How to develop a research question / Laura Kelly and Patrick Stone -- Writing a research proposal / Chris Todd -- How to gain research ethics approval / Peter Speck -- How to use a statistician / Malcolm Campbell -- How to write a paper / Julia M. Addington-Hall. Principles of designing clinical trials in palliative care / Michael I. Bennett -- Ethical and practical issues in designing and conducting clinical trials in palliative care / Yolanda Zuriarrain Reyna, Michael I. Bennett, and Eduardo Bruera -- Survey design / Julia M. Addington-Hall -- Survey research : methods of data collection, questionnaire design, and piloting / Julia M. Addington-Hall -- Experimental and quasi-experimental designs / Massimo Costantini and Irene J. Higginson -- Outcome measurement / Irene J. Higginson and Richard Harding -- Systematic reviews / Marjolein Gysels and Irene J. Higginson -- Qualitative methods of data collection and analysis / Sheila Payne --
  • 2013 ebrary
    Barbara K. Redman.
  • pt. A-B, 2011. ScienceDirect
    pt. B ScienceDirect
    edited by Martin G. Klotz.
    Also available: Print – pt. A-B, 2011.
  • 2010 Karger
    volume editor, Horst Brewitt.
    Trefoil factor family peptide 3 at the ocular surface / Schulze, U.; Sel, S.; Paulsen, F.P. -- Cationic amino acid transporters and [beta]-defensins in dry eye syndrome / Jäger, K. ... [et al.] -- Antimicrobial peptides as a major part of the innate immune defense at the ocular surface / Garreis, F.; Gottschalt, M.; Paulsen, F.P. -- Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT) / Knop, N.; Knop, E. -- Intravital multidimensional real-time imaging of the conjunctival immune system / Gehlsen, U.; Hüttmann, G.; Steven, P. -- Generation of two- and three-dimensional lacrimal gland constructs / Schrader, S. ... [et al.] -- Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency / Pauklin, M. ... [et al.] -- Laser scanning confocal microscopy for conjunctival epithelium imaging / Jürgens, C. ... [et al.] -- Pollen enzymes degrade human tear fluid and conjunctival cells : an approach to understanding seasonal non-allergic conjunctivitis / Rabensteiner, D.F. ... [et al.] -- Towards a new in vitro model of dry eye : the ex vivo eye irritation test / Spöler, F.; Frentz, M.; Schrage, N.F. -- The lid margin is an underestimated structure for preservation of ocular surface health and development of dry eye disease / Knop, E. ... [et al.] -- Diagnostic markers of sjögrenʹs syndrome / Witte, T. -- Hyperosmolarity of the tear film in dry eye syndrome / Messmer, E.M.; Bulgen, M.; Kampik, A. -- Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action / Springs, C.
  • 2015 ScienceDirect
    edited by Mark A. Suckow, University of Notre Dame, Office of Research Notre Dame, IN, USA ; Bill J. Yates, University of Pittsburgh, Department of Otolaryngology Pittsburgh, PA, USA.
    Ch. 1. Human subjects research protections -- Ch. 2. Investigational new drug and device exemption process -- Ch. 3. The institutional animal care and use committee -- Ch. 4. Biological hazards and select agents -- Ch. 5. Radiological hazards and lasers -- Ch. 6. Controlled substances: maintaining institutional compliance -- Ch. 7. Export controls and US research universities -- Ch. 8. Data management and research integrity -- Ch. 9. Intellectual property -- Ch. 10. Financial conflicts of interest in research -- Ch. 11. Good laboratory practices (GLPs) -- Ch. 12. Human embryonic stem cell research oversight: a confluence of voluntary self-regulation and shifting policy initiatives -- Index.
  • 2011 ebrary
    Committee to Study the National Needs for Biomedical, Behavioral, and Research Personnel, Board on Higher Education and Workforce, Policy and Global Affairs, National Research Council of the National Academies.
    "Comprehensive research and a highly trained workforce are essential for the improvement of health and health care both nationally and internationally. Over the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph. D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum."--Publisher's description.
  • 2007
  • 2000
  • 2012 Springer
    Miguel A.R.B. Castanho, Gül Güner-Akdogan, editors.
  • 2012 ebrary
    Joan C. Williams.
    Opt out or pushed out? -- One sick child away from being fired -- Masculine norms at work -- Reconstructive feminism and feminist theory -- The class culture gap -- Culture wars as class conflict.
  • 2014 AccessSurgery
    Debra L. Klamen, Alden H. Harken, Brian C. George, Debra A. DaRosa.
    "Resident Readiness: General Surgery prepares you for success during your surgical internship. Inside is a full range of scenarios you may experience during your residency, supported by comprehension questions with detailed answer explanations and tips to help you remember. You will also learn the clinical problem-solving process so you can think quickly on your feet, especially when time is critical. With the book's step-by-step guidance, you will gain the confidence you need to perform at your best on Day One of your residency"-- Provided by publisher.
  • 2007
    [edited by] Haresh Kirpalani, Aideen M. Moore, Max Perlman.
    Status: Not Checked OutLane Catalog Record
  • 2012 Cambridge
    written by Steven M. Southwick, Dennis S. Charney.
    "Many of us will be struck by one or more major traumas sometime in our lives. Perhaps you have been a victim of sexual abuse, domestic violence or assault. Perhaps you were involved in a serious car accident. Perhaps you are a combat veteran. Maybe you were on the beach in Thailand during a tsunami, or in New Orleans during Hurricane Katrina. Or maybe, you are among the millions who have suffered a debilitating disease, lost a loved one or lost your job. This inspiring book identifies ten key ways to weather and bounce back from stress and trauma. Incorporating the latest scientific research and dozens of interviews with trauma survivors, it provides a practical guide to building emotional, mental and physical resilience. Written by experts in post-traumatic stress, this book provides a vital and successful roadmap for overcoming the adversities we all face at some point in our lives"-- Provided by publisher.
  • 2011 Springer
    Barbara Resnick, Lisa P. Gwyther, Karen A. Roberto, editors.
    Resilience: definitions, ambiguities, and applications -- Successful aging and resilience: applications for public health and health care -- Resilience and personality disorders in older age -- What do we know about resilience in older adults?: an exploration of some facts, factors, and facets -- Psychological resilience -- Physiological resilience -- Using the arts to promote resiliency among persons with dementia and their caregivers -- Promoting worker resilience over the lifecourse -- Resilience in aging: cultural and ethnic perspectives -- Civic engagement: policies and programs to support a resilient aging society -- Strengthened by the spirit: religion, spirituality, and resilience through adulthood and aging -- Resilience in chronic illness -- The relationship between resilience and motivation -- The association between resilience and survival among Chinese elderly -- Fostering resilience in dementia through narratives: contributions of multimedia technologies -- Building resilience in mild cognitive impairment and early-stage dementia: innovative approaches to intervention and outcome evaluation -- African-American caregivers finding resilience through faith -- The age-friendly New York City project: an environmental intervention to increase aging resilience -- Promoting resilience in small-scale, homelike residential care settings for older people with dementia: experiences from the Netherlands and the United States -- A geriatric mobile crisis response team: a resilience-promoting program to meet the mental health needs of community-residing older people -- Optimizing resilience in the 21st century -- Resilience in the workplace: job conditions that buffer negative attitudes toward older workers.
  • 2011 Springer
    Debra H. Zand, Katherine J. Pierce, editors.
    (Publisher-supplied data) Historically, the diagnosis of deafness in a child has been closely associated with profound disability, including such typical outcomes as unmet potential and a life of isolation. A major shift away from this negative view has led to improved prospects for deaf children. Resilience in Deaf Children emphasizes not only the capability of deaf individuals to withstand adversity, but also their positive adaptation through interactions with parents, peers, school, and community. In this engaging volume, leading researchers and professionals pay particular attention to such issues as attachment, self-concept, and social competence, which are crucial to the development of all young people. In addition, the volume offers strategies for family members, professionals, and others for promoting the well-being of deaf children and youth. Coverage includes: Attachment formation among deaf infants and their primary caregivers. Deaf parents as sources of positive development and resilience for deaf infants. Enhancing resilience to mental health disorders in deaf school children. Strength-based guidelines for improving the developmental environments of deaf children and youth. Community cultural wealth and deaf adolescents resilience. Self-efficacy in the management of anticipated work-family conflict as a resilience factor among young deaf adults. Resilience in Deaf Children is essential reading for researchers, clinicians, and graduate students in clinical child, school, and developmental psychology as well as for allied researchers and professionals in such disciplines as school counseling, occupational therapy, and social work.
  • 2008 Springer
    edited by Hans J. Pasman and Igor A. Kirillov.
  • 2013 Springer
    Benjamin Bonavida, editor.
    Introduction and generation of chimeric and humanized mAbs -- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment -- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs -- Mechanisms of antibodies-mediated responses, in vitro and in vivo -- Molecular Pathways -- Molecular Signatures -- Identification of resistance targets for intervention -- Various chemicals that can sensitize resistant tumor cells -- Other mAbs -- Proteasome inhibitors -- Divalent mAbs -- Antibodies coupled to chemical inhibitors -- Antibodies coupled to cytokines -- Nanoparticles with mAbs.
  • 2014 CRCnetBASE
    editors, Joseph T. Ciccolo and William J. Kraemer.
    "Resistance training is a form of strength training in which each effort is performed against a specific, opposing force generated by resistance. Increasing evidence-based research highlights the importance of not only aerobic exercise, but resistance training in the prevention, management, and treatment of many chronic conditions. This book presents research on the benefits of resistance training for chronic diseases/disorders. Chapters cover resistance training to treat cardiovascular disease, metabolic diseases, cancer, orthopedic diseases, and neuromuscular disorders"-- Provided by publisher.
  • 2013 Springer
    Giuseppe Mancia, editor.
    A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.
  • 2008 Springer
    Adriano G. Rossi, Deborah A. Sawatzky, editors.
    Also available: Print – 2008
  • 2005 Ovid
    Bernard Lo.
    An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Confusing ethical distinctions -- Ethics committees and case consultations -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Incentives for physicians to decrease services -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Testing for genetic conditions -- Ethical issues in public health emergencies.
    Also available: Print – 2005
  • 2013 Ovid
    Bernard Lo.
    "Every day clinicians encounter ethical dilemmas that have a direct impact on patient care. This timely Fourth Edition will give you expert guidance in approaching a wide range of ethical dilemmas and developing an action plan even when competing points of view have equal merit. Most chapters include real-life sample cases that the author walks through, discussing the salient issues and how to approach them." "This useful resource is a must-read for medical students and practicing professionals at every level of experience!"--BOOK JACKET.
  • 2009 Ovid
    Bernard Lo.
    Section I. Fundamentals of clinical ethics -- An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- Section II. Shared decision making -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Section III. Decisions about life-sustaining interventions -- Confusing ethical distinctions -- Ethics consultations and ethics committees -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Section IV. The doctor-patient relationship -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Section V. Conflicts of interest -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Measures to control health care costs -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Section VI. Ethical issues in clinical specialties -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Ethical issues in genomic medicine -- Ethical issues in public health emergencies -- Ethical issues in cross-cultural care.
  • 2011
    Qicong Hu.
    Septins are a conserved family of polymerizing GTP/GDP-binding proteins that were discovered in budding yeast as the scaffold for cytokinesis machinery and required for polarized membrane growth. In mammalian cells, they play diverse roles in cytokinesis, cell morphogenesis and as scaffolds and diffusion barriers. Septins are also implicated in many human diseases including cancer and neuropathies. In epithelial cells, formation and maintenance of cell polarity depend on protein sorting from the trans-Golgi network (TGN) and vesicle delivery to the plasma membrane. We show that in epithelial cells septin 2 (SEPT2) fibers colocalize with polyglutamylated (polyGlu) microtubule tracks where vesicles containing apical or basolateral proteins exit, and that SEPT2 maintains polyGlu-microtubule tracks and impedes the binding of tubulin to microtubule-associated protein 4 (MAP4) to facilitate vesicle transport. SEPT2 depletion gives rise to intracellular accumulation of apical and basolateral membrane proteins, a loss of polyGlu-microtubules, and fibroblast-shaped cells. Therefore, SEPT2 is required for polarized epithelia biogenesis. Small molecules that reversibly perturb septin organization and function would be valuable tools for dissecting septin functions and could be used for therapeutic treatment of septin-related diseases. Forchlorfenuron (FCF) is a plant cytokinin previously shown to disrupt septin localization in budding yeast. We show that FCF alters septin assembly in vitro without affecting either actin or tubulin polymerization. In live mammalian cells, FCF dampens septin dynamics, and induces the assembly of abnormally large septin structures. FCF has a low level of cytotoxicity, and these effects are reversed upon FCF wash-out. Significantly, FCF treatment induces mitotic and cell migration defects that phenocopy the effects of septin-depletion by siRNA. FCF would be a promising tool to study mammalian septin organization and functions. In animal cells, the primary cilium transduces extracellular signals through signaling receptors localized in the ciliary membrane, but how these ciliary membrane proteins are retained in the cilium is unknown. We found that ciliary membrane proteins were highly mobile, but their diffusion was impeded at the base of the cilium by a diffusion barrier. SEPT2 localized at the base of the ciliary membrane. SEPT2 depletion resulted in loss of ciliary membrane protein localization and Sonic hedgehog signal transduction, and inhibited ciliogenesis. Thus, SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium. Having demonstrated that there is a diffusion barrier at the base of the primary cilium and ciliary membrane protein is highly mobile in the ciliary membrane, I sought to determine the unknown dynamics and mechanism of ciliary membrane proteins trafficking on ciliary membrane at single molecule level. Here, I used monovalent streptavidin-conjugated fluorophores to image a single ciliary membrane receptor on the ciliary membrane of live cell and resolve their dynamics. The ciliary membrane receptor appears to travel on ciliary membrane by intraflagellar trafficking (IFT) and more efforts are being devoted into studying the mechanisms for ciliary membrane trafficking.
  • 2006
    first draft prepared by Drs. S. Hahn, J. Kielhorn, J. Koppenhöfer, A. Wibbertmann, and I. Mangelsdorf. ... [et al.].
  • 2005 Springer
    Raj B. Durairaj.
  • 2012
    Sabina Stefania Alistar.
    Operations research and mathematical modeling can play a key role in informing high-cost, high-impact health policy decisions. This dissertation describes my research on resource allocation for infectious disease control. Resource allocation is especially difficult in this context because epidemics are nonlinear (preventing one infection now may prevent scores of future infections); interventions usually do not have additive effects; the relationship between investment and outcomes is generally nonlinear and epidemics vary across settings in terms of transmission modes and key risk groups. Hence, the problem of resource allocation for epidemic control is complex and cannot be solved by intuition alone. Decision makers have little guidance in choosing investment portfolios that will provide the maximum health benefits for their particular setting. In Chapter 1, I discuss the gap between the theory and the practice of resource allocation for epidemic control, and identify the key features necessary for a model to be useful in practice. In theoretical work presented in Chapter 2, I address the gap between epidemiological measures and the resource allocation decision. I present a new theoretical framework that quantifies the effects of investment in treatment and prevention interventions on a key epidemiological parameter, the reproductive rate of infection, which measures an outbreak's potential for becoming an epidemic. The approach uses production functions to account for nonlinearities of intervention scale-up effects. I develop analytical results characterizing the optimal solution and present illustrative examples with data for Uganda and Russia. I also present a simple structural estimation technique for evaluating the shape of production functions based on real-world data. In Chapter 3 I develop a dynamic compartmental model of interventions for HIV control in mixed HIV epidemics. I apply the model to analyze the tradeoffs between scaling up methadone substitution therapy for injection drug users and antiretroviral treatment for HIV-infected individuals in Ukraine, a representative case. I show that methadone is an economically attractive option for HIV control, and that excluding drug users from HIV programs significantly limits the benefits that can be obtained by scaling up these interventions. In Chapter 4 I describe a spreadsheet-based planning tool I have created in collaboration with the Joint United Nations Programme on HIV/AIDS (UNAIDS). The REACH (Resource Allocation for Control of HIV) model is designed for use by planners around the world in evaluating investment portfolios for HIV control. The tool is easy to use, includes optimization capability, and accounts for non-additive and nonlinear effects of interventions. I present illustrative implementation of the model for three settings (Uganda, Ukraine and Saint Petersburg, Russia). I also describe my ongoing work with UNAIDS decision makers to test and implement the model for regional and country-level HIV resource allocation. I conclude in Chapter 5 with remarks on the significance of the work and directions for future research.
  • 2012 AccessMedicine
    Andrew L. Lechner, George M. Matuschak, David S. Brink.
    Respiratory system nomenclature and ambient conditions / Andrew J. Lechner -- Development and functional anatomy of the lungs and airways / David S. Brink and Andrew J. Lechner -- Mechanisms of O₂ and CO₂ transport by erythrocytes / Andrew J. Lechner -- Principles of lung ventilation and spirometry / Andrew J. Lechner -- Surfactant biology and lung compliance / Andrew J. Lechner and Mary M. Mayo -- Integrated respiratory system compliance and the work of breathing / Andrew J. Lechner -- Pulmonary circulation and capillary fluid dynamics / Andrew J. Lechner -- Ventilation/perfusion matching and estimating alveolar ventilation / Andrew J. Lechner -- Alveolar O₂ and CO₂ exchange, physiological shunt, and acid-base balance / Andrew J. Lechner -- Airway and parenchymal defense mechanisms / Andrew J. Lechner and George M. Matuschak -- Central and peripheral neural controls of respiration / W. Michael Panneton and Andrew J. Lechner -- Importance and derivation of aerobic capacity / Gerald S. Zavorsky and Andrew J. Lechner -- Respiratory responses to extreme environments / Gerald S. Zavorsky and Andrew J. Lechner -- Conduct and interpretation of the basic chest exam / William C. Mootz and George M. Matuschak -- Interpreting chest x-rays, CT scans, and MRIs / Ashutosh Sachdeva and George M. Matuschak -- Pulmonary function testing, plethysmography, and pulmonary diffusing capacity / Gerald S. Zavorsky and Andrew J. Lechner -- Blood gas analyses and their interpretation / Mary M. Mayo and Andrew J. Lechner -- Diagnostic flexible bronchoscopy / David A. Stoeckel and George M. Matuschak -- Evaluating sputum and pleural effusions / Mary M. Mayo and Andrew J. Lechner -- Pathology of obstructive pulmonary diseases / David S. Brink and Andrew J. Lechner -- Diagnosis and management of asthma / Joseph R.D. Espiritu and George M. Matuschak -- Management of chronic obstructive pulmonary diseases / Joseph R.D. Espiritu and George M. Matuschak -- Pathology of restrictive lung diseases / David S. Brink -- Management of restrictive lung diseases / Ravi P. Nayak and George M. Matuschak -- Management of sleep-related breathing disorders / Joseph R.D. Espiritu and George M. Matuschak -- Pathology of atelectatic, vascular, and iatrogenic diseases of the lungs and pleural space / David S. Brink -- Pulmonary embolism / Ashutosh Sachdeva and George M. Matuschak -- Acute lung injury and the acute respiratory distress syndrome: pathophysiology and treatment / George M. Matuschak and Andrew J. Lechner -- Pathophysiology and diseases of the pleural space / George M. Matuschak and Andrew J. Lechner -- Principles and goals of mechanical ventilation / Dayton Dmello and George M. Matuschak -- Pathology of lung tumors / David S. Brink -- Lung cancer / David A. Stoeckel and George M. Matuschak -- Diseases of the upper airways and sinuses / David S. Brink and Andrew J. Lechner -- Pathology of lung infections / David S. Brink -- Management of pneumonias / David A. Stoeckel and George M. Matuschak -- Mycobacterial diseases in the lung / Ashutosh Sachdeva and George M. Matuschak -- Congenital anomalies of the respiratory system / Gary M. Albers and Andrew J. Lechner -- Presentation and management of cystic fibrosis / Blakeslee E. Noyes and Andrew J. Lechner -- Neonatal respiratory distress syndrome and sudden infant death syndrome / Robert E. Fleming, W. Michael Panneton, and Andrew J. Lechner -- Lower respiratory tract infections in children / Blakeslee E. Noyes and George M. Matuschak.
  • 2015 Springer
    Mieczyslaw Pokorski, editor.
    The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.
    Also available: Print – 2015
  • 2007
    by Will Beachey.
    Status: Not Checked OutLane Catalog Record
  • 2016 Springer
    edited by Mieczyslaw Pokorski.
    The Stress Reaction: a Historical Perspective, O. Rom, and A.Z. Reznick -- The Environmental Domain of Quality of Life in Patients with Chronic Respiratory Diseases, D. Kurpas, K. Szwamel, and B. Mroczek -- Incidence and Clinical Course of Respiratory Viral Coinfections in Children Aged 0-59 Months, A .Nitsch-Osuch, E. Kuchar, A. Topczewska-Cabanek, K. Wardyn, K. Życińska, and L. Brydak -- Antibiotic Prescription Practices among Children with Influenza, A. Nitsch-Osuch, E. Gyrczuk, A. Wardyn, K. Życinska, and L. Brydak -- Antigenic Drift of A/H3N2/ Virus and Circulation of Influenza-Like Viruses During the 2014/2015 Influenza Season in Poland, K. Bednarska, E. Hallmann-Szelińska, K. Kondratiuk, and L.B. Brydak -- Growing Antibiotic Resistance in Fatal Cases of Staphylococcal Pneumonia in the Elderly, J. Yayan, and K. Rasche -- Polymorphism of FCGR2A, FCGR2C, and FCGR3B Genes in the Pathogenesis of Sarcoidosis, M. Typiak, K. Rębala, M. Dudziak, J.M. Słomiński, and A. Dubaniewicz -- Chronic Cough as a Female Gender Issue, N. Kavalcikova-Bogdanova, T. Buday, W.J. Song, and J. Plevkova -- Treatment Options for Central Sleep Apnea: Comparison of Ventilator, Oxygen, and Drug Therapies, J. Yayan, and K. Rasche -- The Guinea Pig Sensitized by House Dust Mite: a Model of Experimental Cough Studies, T. Buday, S. Gavliakova, J. Mokry, I. Medvedova, N. Kavalcikova-Bogdanova, and J. Plevkova -- Index.
    Also available: Print – 2016
  • 2007
    [edited by] Robert L. Wilkins, James R. Dexter, Philip M. Gold.
    Status: Not Checked OutLane Catalog Record
    Introduction to patient assessment / Robert L. Wilkins, Philip M. Gold -- Introduction to respiratory failure / Robert L. Wilkins, James R. Dexter -- Asthma / Robert L. Wilkins, Philip M. Gold -- Chronic obstructive pulmonary disease / Robert L. Wilkins, Philip M. Gold -- Cystic fibrosis / N. Lennard Specht -- Hemodynamic monitoring and shock / Robert L. Wilkins, James R. Dexter -- Pulmonary thromboembolic disease / James R. Dexter -- Heart failure / Arthur B. Marshak, George H. Hicks -- Smoke inhalation injury and burns / George H. Hicks, Carl A. Eckrode -- Near drowning / William F. Galvin -- Acute respiratory distress syndrome / Robert L. Wilkins, James R. Dexter -- Chest trauma / George H. Hicks, Carl A. Eckrode -- Postoperative atelectasis / Thomas P. Malinowski -- Interstitial lung disease / N. Lennard Specht -- Neuromuscular diseases / N. Lennard Specht, Rebekah Bartos Specht -- Bacterial pneumonia / Robert L. Wilkins, James R. Dexter -- Pneumonia in the immunocompromised patient / Philip M. Gold, N. Lennard Specht -- Sleep disordered breathing / Enrique Gil -- Tuberculosis / James R. Dexter, Robert L. Wilkins -- Lung cancer / Gregory A.B. Cheek -- Appendix A: Normal laboratory values -- Appendix B: GOLD standards for diagnosing and treating patients with COPD -- Appendix C: Websites useful for learning information about the diagnosis and treatment of lung diseases.
  • 2009 Springer
    [edited by] A. McLuckie.
  • 2015 Springer
    Mieczyslaw Pokorski, editor.
    The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.
    Also available: Print – 2015
  • 2015 Springer
    Mieczyslaw Pokorski, editor.
    Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children / Wrotek, T. Jackowska, and K. Pawlik -- Detection of respiratory tract pathogens with molecular biology methods / Wozniak-Kosek, J. Kosek, and B. Zielnik-Jurkiewicz -- Classical against molecular-genetic methods for susceptibility testing of antituberculotics / I. Porvaznik, J. Mokry, and I. Solovic -- Does customer information fulfill MEDDEV criteria in cases of product problems of in vitro diagnostics for infection testing? / Jürgen Hannig and Rüdiger Siekmeier -- Sodium and copeptin levels in children with community acquired pneumonia / August Wrotek, Teresa Jackowska, and Katarzyna Pawlik -- Etiological factors causing lower respiratory tract infections isolated from hospitalized patients / A. Guzek, Z. Rybicki, K. Korzeniewski, K. Mackiewicz, E. Saks, A. Chciałowski, and E. Zwolińska -- Antibiotic consumption pattern in the neonatal special care unit before and after implementation of the hospital's antibiotic policy / Nitsch-Osuch, D. Kurpas, E. Kuchar, K. Życińska, T. Zielonka, and K. Wardyn -- Respiratory tract infections in children in primary healthcare in Poland / E. Kuchar, K. Miśkiewicz, L. Szenborn, and D. Kurpas -- Impact of updated European consensus guidelines on the management of neonatal respiratory distress syndrome on clinical outcome of preterm infants / S. Smolarova, L. Kocvarova, K. Matasova, M. Zibolen, and A. Calkovska -- Index.
    Also available: Print – 2015
  • 2016 Springer
    Mieczyslaw Pokorski, editor.
    Molecular characteristics of influenza virus Type B lineages circulating in Poland / K. Bednarska, E. Hallmann-Szelińska, K. Kondratiuk, D. Rabczenko, and L.B. Brydak -- Obstructive sleep apnea is realted to increased arterial stiffness in ultrasound speckle-tracking analysis / I. Tuleta, D. Skowasch, J. Krycki, C. Pizarro, C. Hammerstingl, M. Weber, N. Schahab, G. Nickenig, C. Schaefer, and S. Pingel -- Sclerostin in obstructive sleep apnea / M. Kosacka, I. Porębska, and A. Brzecka -- Atherosclerotic vessel changes in sarcoidosis / I. Tuleta, S. Pingel, L. Biener, C. Pizarro, C. Hammerstingl, C. Öztürk, N. Schahab, C. Grohé, G. Nickenig, C. Schaefer, and D. Skowasch -- Asthma and COPD: similarities and differences in the pathophysiology, diagnosis and therapy / Josef Yayan and Kurt Rasche -- Intracellular and extracellular cytokines in A549 cells and THP1 cells exposed to cigarette smoke / A. Holownia, P. Wielgat, E. Rysiak, and J.J. Braszko -- Frequency of rare Alpha-1 antitrypsin variants in Polish patients with chronic respiratory disorders / K. Duk, A. Zdral, B. Szumna, A. Roży, and J. Chorostowska-Wynimko -- Influence of body shape composition on respiratory function in adult women / Z. Czapla, A. John, A. Szwed, T. Hané, M. Durda, J. Ratajczak, and E. Barłóg -- Concurrent validity and reliability of a new balance scale used in older adults / Oz Zur, Tamar Shaki, and Eli Carmeli -- Quality of care for patients with chronic respiratory diseases: data for accreditation plan in primary healthcare / Donata Kurpas, Katarzyna Szwamel, and Bożena Mroczek -- Index.
    Also available: Print – 2016
  • 2009- Springer
    Rounds, Sharon.
  • 2013 ScienceDirect
    Alison McConnell ; foreword by Rik Gosselink ; illustrations by Bruce Hogarth.
    Respiratory Muscle Training: theory and practice is the world's first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts - theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge - and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (www.physiobreathe.com), which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via www.physiotec.ca), which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. Introductory overviews of respiratory and exercise physiology, as well as training theory Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation Evidence-based guidance on the implementation of inspiratory muscle resistance training Over 150 functional exercises that incorporate a breathing challenge www.physiobreathe.com - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec's RMT exercise module (via www.physiotec.ca)
  • 2008
    John B. West.
    Status: Not Checked OutLane Catalog Record
  • 2013 Springer
    Mieczyslaw Pokorski, editor.
    Also available: Print – 2013
  • 2013 Springer
    Mieczyslaw Pokorski, editor.
    Also available: Print – 2013
  • 2007 ScienceDirect
    editor, Patricia Cane.
  • 2008 Springer
    [edited by] Umberto Lucangelo ... [et al.].
  • 2009 Springer
    Derek S. Wheeler, Hector R. Wong, and Thomas P. Shanley, (eds.).
    Respiratory physiology -- Disorders of the pediatric chest -- Respiratory monitoring -- Bronchoscopy in the pediatric intensive care unit -- Acute lung injury and acute respiratory distress syndrome -- Mechanical ventilation -- Ventilator-induced lung injury -- Prone positioning -- High-frequency oscillatory ventilation -- Pulmonary surfactant: biology and therapy -- Nitric oxide -- Extracorporeal life support for children with acute respiratory failure -- Diseases of the upper respiratory tract -- Congenital airway and respiratory tract anomalies -- Status asthmaticus -- Bronchiolitis -- Pneumonia and empyema -- Pediatric lung transplantation -- Neuromuscular respiratory failure -- Diseases of the pulmonary vascular system.
  • 2015 Springer
    edited by Mieczyslaw Pokorski.
    This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.
    Also available: Print – 2015
  • 2016 Springer
    Mieczyslaw Pokorski, editor.
    Growth, nutritional status, and pulmonary function in children with chronic recurrent bronchitis -- Next-generation sequencing of 5' untranslated region of hepatitis C virus in search of minor viral variant in a patient who revealed new genotype while on antiviral treatment -- Swelling of erectile nasal tissue induced by human sexual pheromone -- Influenza vaccination coverage rate for medical staff: influence of hospital-based vaccination campaign -- Relationships between tobacco abuse and self-assessment of health -- The role of inspiratory muscle training in the process of rehabilitation of patients with chronic obstructive pulmonary disease -- Socioeconomic effects of chronic obstructive pulmonary disease from the public payer's perspective in Poland -- Costs of treatment of chronic obstructive pulmonary disease -- Coexpression of galanin and nestin in the chemoreceptor cells of the human carotid body -- Prosthetic rehabilitation of patients after surgical treatment of maxillary tumors with respect to upper airway protection -- Respiratory toxicity of dimethyl sulfoxide.
    Also available: Print – 2016
  • 2013 WHO
    A health-care provider is likely to be the first professional contact for survivors of intimate partner violence or sexual assault. Evidence suggests that women who have been subjected to violence seek health care more often than non-abused women, even if they do not disclose the associated violence. They also identify health-care providers as the professionals they would most trust with disclosure of abuse. These guidelines are an unprecedented effort to equip healthcare providers with evidence-based guidance as to how to respond to intimate partner violence and sexual violence against women. They also provide advice for policy makers, encouraging better coordination and funding of services, and greater attention to responding to sexual violence and partner violence within training programmes for health care providers. The guidelines are based on systematic reviews of the evidence, and cover: 1. identification and clinical care for intimate partner violence 2. clinical care for sexual assault 3. training relating to intimate partner violence and sexual assault against women 4. policy and programmatic approaches to delivering services 5. mandatory reporting of intimate partner violence. The guidelines aim to raise awareness of violence against women among health-care providers and policy-makers, so that they better understand the need for an appropriate health-sector response. They provide standards that can form the basis for national guidelines, and for integrating these issues into health-care provider education.
    Also available: Print – 2013
  • 2008
    Chun-Chun Chen.
    Status: Not Checked OutLane Catalog Record
  • 2014 Springer
    Simone Arnaldi, Arianna Ferrari, Paolo Magaudda, Frances Marin, editors.
    This book disentangles the complex meanings of responsibility in nanotechnology development by focusing on its theoretical and empirical dimensions. The notion of responsibility is extremely diversified in the public discourse of nanoscale technologies. Addressed are major disciplinary perspectives working on nanotechnology, e.g. philosophy, sociology, and political science, as well as the major multidisciplinary areas relevant to the innovation process, e.g. technology assessment and ethics. Furthermore, the interplay between such expertises, disciplines, and research programmes in providing a multidisciplinary understanding of responsibility is emphasized.
  • 2009 OSO
    Adil E. Shamoo and David B. Resnik.
    Scientific research and ethics -- Ethical decision making -- Data acquisition and management -- Mentoring and collaboration -- Collaboration between academia and private industry -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The protection of human subjects in research -- Protecting vulnerable human subjects in research -- Genetics, cloning, and stem cell research -- International research.
  • Jon Flanders.
  • 2012
    Michael Cunyuan Chen.
    Insomnia is a prevalent and costly disorder of sleep-related distress, yet little is known about its etiology. To better understand the neurobiology underlying insomnia, we examined resting state and directed sleep brain activity in insomniacs and healthy controls using simultaneous blood oxygen level-dependent (BOLD) signal functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Using dual regression analysis of BOLD signal brain networks derived from independent component analysis, we found increased coactivation of the insula in salience networks in insomniacs compared to healthy controls. This increase was accompanied by altered EEG power in insomniacs compared to healthy controls, as well as altered BOLD connectivity signatures of EEG frequency bands. These results suggest that aberrant connectivity of the insula and salience networks contribute to neural dysfunction in insomnia.
  • 2009 ClinicalKey
    [edited by] Wayne A. Hening [and others].
    Introduction -- General introduction: Restless Legs Syndrome as a neurological conundrum -- Patient's perspective -- From 1685 to 2008: an introduction to Restless Legs Syndrome -- Restless Legs Syndrome as a movement disorder -- Restless Legs Syndrome and nocturnal myoclonus (periodic limb movements during sleep) -- Clinical science of Restless Legs Syndrome -- Basic science of Restless Legs Syndrome -- Epidemiology and genetics -- Epidemiology of Restless Legs Syndrome -- Genetics of Restless Legs Syndrome -- Pathophysiology -- Iron metabolic system -- Iron dysregulation in Restless Legs Syndrome -- Brain's dopaine systems and their relevance to Restless Legs Syndrome -- Neuroimaging in Restless Legs Syndrome -- Circadian rhythm of Restless Legs Syndrome -- Spinal cord, dopamine, opiates, and Restless Legs Syndrome -- Clinical science of Restless Legs Syndrome -- Diagnosis -- Diagnosis of Restless Legs Syndrome -- Differential diagnosis of Restless Legs Syndrome -- Periodic limb movements in sleep -- Sleep laboratory diagnosis of Restless Legs Syndrome -- Actigraph assessment of periodic leg movements and Restless Legs Syndrome -- Assessment of Restless Legs Syndrome features with standardized methods -- Comorbidities and special populations -- Restless Legs Syndrome and periodic limb movement disorder in childhood and adolescence -- Restless Legs Syndrome and pregnancy -- Restless Legs Syndrome and periodic limb movements in the elderly with and without dementia -- Restless Legs Syndrome in medical disorders -- Restless Legs Syndrome in neurological disorders -- Is the manifestation of the Restless Legs Syndrome related to a pain mechanism? -- Restless Legs Syndrome and psychiatric disorders -- Management -- Introduction to management of Restless Legs Syndrome -- Nonpharmacological considerations and treatment of Restless Legs Syndrome -- Dopaminergic therapy of Restless Legs Syndrome -- Opioid agents in the treatment of Restless Legs Syndrome -- Anticonvulsants in the treatment of Restless Legs Syndrome -- Iron treatment -- Additional agents and miscellaneous therapies -- Management of Restless Legs Syndrome in the hospital and during surgery -- Restless Legs Syndrome morbidity: sleep and quality of life -- History of the Restless Legs Syndrome Foundation.
  • 2016 Springer
    Jorge Perdigão.
    1. Endodontic considerations for the restoration of endodontically treated teeth --2. Effect of endodontic treatment procedures on canal shape and mechanical properties of a tooth -- 3. Restoring the endodontically treated tooth: treatment planning considerations -- 4. Fiber-reinforced dental materials in the restoration of root-canal treated teeth -- 5. Biomechanical principles of root canal-treated-teeth restored with fiber-reinforced resin posts -- 6. Fiber-reinforced resin posts (fiber posts) -- 7. Adhesion to root dentin: a challenging task -- 8. Methods for increasing the longevity of adhesion to root canal dentin -- 9. Selection of luting materials for bonding fiber posts -- 10. Provisional restorations -- 11. Cast dowel and core -- 12. Clinical sequence.
  • 2006 Springer
    Patrik Brundin, C. Warren Olanow, editors.
  • v. 2-, 1971- Springer
    Beermann, W.; Hennig, Wolfgang; Kloc, Malgorzata; Kubiak, Jacek Z.; Nover, Lutz; Oostra, Ben A.; Richter, Dietmar; Scheer, U.; Tiedge, Henri.
  • Yate, Martin John.
    Status: Not Checked OutLane Catalog Record
  • 2009 Wellcome Trust
    edited by S.M. Crowther, L.A. Reynolds and E.M. Tansey.
  • 2009 Springer
    Derek S. Wheeler, Hector R. Wong, and Thomas P. Shanley, (eds.).
    Emergency Medical Services for Children / Derek S. Wheeler and Tom LeMaster -- Pediatric Cardiopulmonary Resuscitation / Vinay M. Nadkarni and Robert A. Berg -- Supplemental Oxygen and Bag-Valve-Mask Ventilation / Patricia Abboud, Jennifer Raake, and Derek S. Wheeler -- Assessment and Management of the Pediatric Airway / Derek S. Wheeler, James P. Spaeth, Renuka Mehta, Suriyanarayana P. Hariprakash, and Peter N. Cox -- Vascular Access / Jennifer Kaplan and Richard J. Brilli -- Shock: An Overview / Joseph A. Carcillo, Derek S. Wheeler, Neil W. Kooy, and Thomas P. Shanley -- Acute Respiratory Failure / Jennifer L. Turi and Ira M. Cheifetz -- Pediatric Transport Medicine / Derek S. Wheeler and W. Bradley Poss -- Withdrawal of Life Support / Kathleen L. Meert and Ashok P. Sarnaik -- Brain Death / Sam D. Shemie -- The Pathophysiology of Brain Death and Care of the Potential Organ Donor / Sam D. Shemie.
  • 2014 Springer
    Antonino Gullo, Giuseppe Ristagno, editors ; foreword by Massimo Antonelli.
    Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.
  • 2006 CRCnetBASE
    edited by Bharat B. Aggarwal and Shishir Shishodia.
  • 2008 Springer
    edited by Léna Soler, Howard Sankey, and Paul Hoyningen-Huene.
  • 2012 Springer
    Patricia O'Campo, James R. Dunn, editors.
    Explanations, philosophy and theory in health inequalities research: towards a critical realist approach -- Values and social epidemiologic research -- Population-based data and community empowerment -- Differences that matter -- Context -- Place-based stress and chronic disease: a systems view of environmental determinants -- How goes the neighbourhood? Rethinking neighbourhoods and health research in social epidemiology -- Application of two schools of social theory to neighbourhood, place and health research -- Locating politics in social epidemiology -- Research tools in action -- Structural violence and structural vulnerability within the risk environment: theoretical and methodological perspectives for a social epidemiology of HIV risk among injection drug users and sex workers -- Realist review methods for complex health problems -- Addressing health equalities in social epidemiology: learning from evaluation(s) -- Making a difference -- Knowledge translation and social epidemiology: taking power, politics and values seriously -- Community-academic partnerships and social change -- Producing more relevant evidence: applying a social epidemiology research agenda to public health practice.
  • 2010 Springer
    Louise Cummings.
  • 2008 ClinicalKey
    by Adam H. Rogers, Jay S. Duker.
    Diabetes -- Age-related macular degeneration -- Vascular obstructions -- Pediatric -- Trauma -- Tumors -- Retinal detachment and allied diseases -- Vitreous -- Macular diseases -- Retinal dystrophies -- White dot syndromes -- Inflammatory diseases -- Infectious diseases.
  • 2009 ClinicalKey
    edited by Abdhish R. Bhavsar.
    1 Scleral buckling surgery -- 2 Vitrectomy surgery -- 3 23-gauge vitrectomy -- 4 25-gauge vitrectomy -- 5 Epiretinal membrane surgery -- 6 Macular hole surgery -- 7 Proliferative diabetic retinopathy and vitreous hemorrhage -- 8 Surgical management for open-globe injuries -- 9 Surgery for proliferative vitreoretinopathy -- 10 Surgery for submacular hemorrhage -- 11 Intravitreal injections -- 12 Pneumatic retinopexy -- 13 Fluid-air exchange/fluid-gas exchange -- 14 Drainage of choroidal hemorrhage, detachment, or effusion s-- 15 Vitreous implants -- 16 Vitreous biopsy for endophthalmitis or cytology -- 17 Treatment of advanced retinopathy of prematurity: peripheral retinal ablation -- 18 Scleral buckle surgery for retinal detachment associated with neonatal retinopathy of prematurity -- 19 Vitrectomy surgery for retinopathy of prematurity -- 20 Surgery for intraocular tumors -- 21 Vitrectomy technology and techniques.
  • 2009 Thieme Book
    Homayoun Tabandeh, Morton F. Goldberg.
    Retina in Systemic Disease: A Color Manual of Ophthalmoscopy is a practical reference for using ophthalmoscopy to recognize the retinal manifestations of systemic diseases and to confidently develop a diagnosis on the basis of such findings. Divided into three main sections, the book opens with a discussion of anatomy and the normal fundus and then provides straightforward, step-by-step instructions of examination techniques with valuable pearls on how to optimize the visualization of the retina. Numerous chapters in the second section of the book present the major clinical signs in the retina with concise lists of conditions associated with each sign. The third section provides comprehensive coverage of various systemic disorders, enabling the clinician to rapidly locate information useful for diagnosis, staging, and treatment. Each chapter in this section provides a brief description of the disorder, fundus features, additional ophthalmic features, and where appropriate, management techniques and differential diagnosis.
  • v.1-3, 2013 ClinicalKey
    editor-in-chief, Stephen J. Ryan.
    Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
  • v. 1-3, 2006.
    editor-in-chief, Stephen J. Ryan.
    Status: Not Checked OutLane Catalog Record
    v. 1. Basic science, inherited retinal disease, and tumors -- v. 2. Medical retina -- v. 3. Surgical retina.
  • 2008 Springer
    edited by J.S. Penn.
    1. Cellular and molecular mechanisms of retinal angiogenesis / M.A. Behzadian et. al -- 2. Animal models of choroidal neovascularization / M.L. Clark, J.A. Fowler, and J.S. Penn -- 3. Rodent models of oxygen-induced retinopathy / S.E. Yanni, G.W. McCollum, and J.S. Penn -- 4. Animal models of diabetic retinopathy / T.S. Kern -- 5. Neovascularization in models of branch retinal vein occlusion / R.P. Danis and D.P. Bingaman -- 6. Vasculogenesis and angiogenesis in formation of the human retinal vasculature / T. Chan-Ling -- 7. IGF-1 and retinopathy / L.E.H. Smith -- 8. Hypoxia and retinal neovascularization / B.A. Berkowitz -- 9. Hypoxia inducible Factor-1 and VEGF induction / A. Madan -- 10. The role of protein kinase C in diabetic retinal vascular abnormalities / J.K. Sun and G.L. King -- 11. Eph receptor tyrosine kinases: modulators of angiogenesis / J. Chen, D. Brantley-Siders, and J.S. Penn -- 12. Adenosine in retinal vasculogenesis and angiogenesis in oxygen-induced retinopathy / G.A. Lutty and D.S. McLeod -- 13. The regulation of retinal angiogenesis by cyclooxygenase and the prostanoids / G.W. McCollum and J.S. Penn -- 14. Extracellular proteinases in ocular angiogenesis / A. Das and P.G. McGuire -- 15. Oxygen-independent angiogenic stimuli / J.M. Holmes, D.A. Leske, and W.L. Lanier -- 16. Growth factor synergy in angiogenesis / A.V. Ljubimov -- 17. Pigment epithelium derived factor and angiogenesis / J. Amaral and S.P. Becerra -- 18. Circulating endothelial progenitor cells and adult vasculogenesis / S. Caballero, N. Sengupta, L.C. Shaw, and M.B. Grant -- 19. Retinopathy of prematurity / D.L. Phelps -- 20. Angiogenesis in sickle cell retinopathy / G.A. Lutty and D.S. McLeod -- 21. Diabetic retinopathy / R.N. Frank -- 22. Systems for drug delivery to the posterior segment of the eye / A.L. Weiner and D.A. Marsh -- 23. Novel therapeutic strategies for posterior segment neovascularization / D.P. Bingaman, X. Gu, A.M. Timmers, and A. Davis -- 24. Choroidal neovascularization in age-related macular degeneration- from mice to man / L. Berglin.
  • 2013 Springer
    J. Fernando Arévalo, editor.
    This book presents the current information on retinal and choroidal manifestations of systemic diseases from leading experts in the field and is intended for ophthalmologists, retina specialists, uveitis and ocular oncology specialists. The topics discussed in this book are not all inclusive, but include retinal and choroidal manifestations of AIDS, diffuse unilateral subacute neuroretinitis (DUSN), posterior pole manifestations of cycticercosis, toxocariasis, tuberculosis, toxoplasmosis, viral diseases, fungal diseases, endogenous endophthalmitis, sarcoidosis, diabetic retinopathy, and many more.
  • 2010 ClinicalKey
    Lawrence A. Yannuzzi.
    Over 5,000 illustrations of the latest imaging and research findings essential for effective diagnosis of retinal disorders populate this atlas. A unique page layout consisting of optimally positioned panoramic images, magnified photos, and histopathological specimens illustrate key manifestations, giving you the best visual display of each disease. In addition, composite images using different retinal imaging modalities, including the latest in optical coherence tomography (OCT), fluorescein angiography, indocyanine green (ICG), and fundus autofluorescence display how a disease appears in each imaging modality, allowing you to compare imaging methods and gain a better understanding of each disorder.
  • 2012 Springer Protocols
    edited by Bernhard H.F. Weber and Thomas Langmann.
    Identification and Analysis of Inherited Retinal Disease Genes / Kornelia Neveling [and others] -- Mouse Models for Studies of Retinal Degeneration and Diseases / Bo Chang -- Retinal Fundus Imaging in Mouse Models of Retinal Diseases / Anne F. Alex, Peter Heiduschka, and Nicole Eter -- Functional Phenotyping of Mouse Models with ERG / Naoyuki Tanimoto, Vithiyanjali Sothilingam, and Mathias W. Seeliger -- Phenotyping of Mouse Models with OCT / M. Dominik Fischer, Ahmad Zhour, and Christoph J. Kernstock -- Light Damage as a Model of Retinal Degeneration / Christian Grimm and Charlotte E. Remé -- N -Methyl-D-Aspartate (NMDA)-Mediated Excitotoxic Damage: A Mouse Model of Acute Retinal Ganglion Cell Damage / Roswitha Seitz and Ernst R. Tamm -- Generation of Transgenic X. laevis Models of Retinal Degeneration / Beatrice M. Tam [and others] -- Analysis of Photoreceptor Degeneration in the Zebrafish Danio rerio / Holger Dill [and others] -- Analysis of Optokinetic Response in Zebrafish by Computer-Based Eye Tracking / Sabina P. Huber-Reggi [and others] -- Analysis of the Drosophila Compound Eye with Light and Electron Microscopy / Monalisa Mishra and Elisabeth Knu -- Cell-Specific Markers for the Identification of Retinal Cells by Immunofluorescence Microscopy / Christiana L. Cheng, Hidayat Djajadi, and Robert S. Molday -- A Method of Horizontally Sliced Preparation of the Retina / Ryosuke Enoki and Amane Koizumi -- Detection of DNA Fragmentation in Retinal Apoptosis by TUNEL / Francesca Doonan and Thomas G. Cotter -- High-Throughput RNA In Situ Hybridization in Mouse Retina / Seth Blackshaw -- Assessment of Mitochondrial Damage in Retinal Cells and Tissues Using Quantitative Polymerase Chain Reaction for Mitochondrial DNA Damage and Extracellular Flux Assay for Mitochondrial Respiration Activity / Stuart G. Jarrett [and others] -- Analysis of Photoreceptor Rod Outer Segment Phagocytosis by RPE Cells In Situ / Saumil Sethna and Silvia C. Finnemann -- Ca2+Microfluorimetry in Retinal Müller Glial Cells / Antje Wurm, Thomas Pannicke, and Andreas Reichenbach -- Functional Analysis of Retinal Microglia and Their Effects on Progenitors / Debra A. Carter, Balini Balasubramaniam, and Andrew D. Dick -- Analysis of Photoreceptor Outer Segment Phagocytosis by RPE Cells in Culture / Yingyu Mao and Silvia C. Finnemann -- Ca2+-Imaging Techniques to Analyze Ca2+ Signaling in Cells and to Monitor Neuronal Activity in the Retina / Olaf Strauss -- Double Chromatin Immunoprecipitation: Analysis of Target Co-occupancy of Retinal Transcription Factors / Guang-Hua Peng and Shiming Chen -- Quantifying the Activity of cis-Regulatory Elements in the Mouse Retina by Explant Electroporation / Cynthia L. Montana, Connie A. Myers, and Joseph C. Corbo -- Optimized Technique for Subretinal Injections in Mice / Regine Mühlfriedel [and others] -- Adeno-Association Viral Vectors for Gene Therapy of Inherited Retinal Degenerations / John G. Flannery and Meike Visel -- Barrier Modulation in Drug Delivery to the Retina / Matthew Campbell, Marian M. Humphries, and Peter Humphries.
  • 2007 Springer
    edited by Joyce Tombran-Tink and Colin J. Barnstable.
    Coping with retinal degeneration : a patient's view / Gordon Cousins and James Cape -- Epidemiology of age-related macular degeneration early in the 21st century / Jie Jin Wang, Paul Mitchell, and Ronald Klein -- Leber congenital amaurosis : a hereditary childhood form of blindness and a model to elucidate retinal physiology and development / Robert K. Koenekoop -- Macular degeneration : aging changes and novel therapies / Peter E. Liggett and Alejandro J. Lavaque -- Stargardt disease : from gene discovery to therapy / Rando Allikmets -- X-linked juvenile retinoschisis / Bernhard H. F. Weber and Ulrich Kellner -- Retinal degeneration in Usher syndrome / David S. Williams -- Mouse models of retinitis pigmentosa / Bo Chang ... [et al.] -- The impact of diabetes on neuronal, glial, and vascular cells of the retina : implications for the pathogenesis of diabetic retinopathy / Sylvia B. Smith -- Statins and age-related maculopathy / Gerald McGwin, Jr. and Cynthia Owsley -- The role of drusen in macular degeneration and new methods of quantification / R. Theodore Smith and Umer F. Ahmad -- RPE lipofuscin : formation, properites, and relevance to retinal degeneration / Janet R. Sparrow -- Genetic modifiers that affect phenotypic expression of retinal diseases / Malia M. Edwards ... [et al.] -- X-linked retinal dystrophies and microtubular functions within the retina / Alan F. Wright and Xinhua Shu -- Synaptic remodeling in retinal degeneration / You-Wei Peng and Fulton Wong -- On the suppression of photoreceptor cell death in retinitis pigmentosa / Fiona Kernan ... [et al.] -- Cell-based therapies to restrict the progress of photoreceptor degeneration / Raymond D. Lund and Shaomei Wang -- Current status of IPE transplantation and its potential as a cell-based therapy for age-related macular degeneration and retinal dystrophies / Makoto Tamai -- Recent results in retinal transplantation give hope for restoring vision / Robert B. Aramant, Norman D. Radtke, and Magdalene J. Seiler -- Stem cells and retinal transplantation / Joanne Yau ... [et al.] -- Application of encapsulated cell technology for retinal degenerative diseases / Weng Tao and Rong Wen -- Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leber's congenital amaurosis / Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger -- The use of neuroprotective factors in retinal degenerations / Joyce Tombran-Tink and Colin J. Barnstable -- Carbonic anhydrase inhibitors as a possible therapy for RP17, an autosomal dominant retinitis pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response / George Rebello, Jacquie Greenberg, and Raj Ramesar -- Macular Degeneration- an addendum / Joyce Tombran-Tink and Colin J. Barnstable.
    Also available: Print – 2007
  • 2012 Springer
    Matthew M. LaVail, John D. Ash, Robert E. Anderson, Joe G. Hollyfield, Christian Grimm, editors.
    Part 1. AMD: Basic Mechanisms, Inflammation and Immunity -- Part 2. Neuroprotection, Drugs and Novel Protective Therapies -- Part 3. Gene Therapy -- Part 4. Blood Vessels, Angiogenesis, and Neovascularization -- Part 5. Genotype/Phenotype -- Part 6. New Animal Models of Retinal Degeneration -- Part 7. Analysis of Retinal Degeneration by Imaging and Functional Testing -- Part 8. Mechanisms of Retinal Degeneration -- Part 9. Retinal Development, Physiology, Cell and Molecular Biology.
    Also available: Print – 2012
  • 2006 Springer
    edited by Joe G. Hollyfield, Robert E. Anderson, and Matthew M. LaVail.
    Molecular genetics and candidate genes -- Diagnostic, clinical, cytopathological, and physiologic aspects of retinal degeneration -- Animal models of retinal degeneration -- Gene therapy and neuroprotection -- Usher syndrome -- Stem cells, transplantation, and retinal repair -- Induced retinal degenerations.
    Also available: Print – 2006
  • 2010 Springer
    Robert E. Anderson, Joe G. Hollyfield, Matthew M. LaVail, editors.
    Also available: Print – 2010
  • 2016 Springer
    editors: Catherine Bowes Rickman, Matthwe M. LaVail, Robert E. Anderson, Christian Grimm, Joe Hollyfiels, John Ash.
    Also available: Print – 2016
  • 2014 Springer
    John D. Ash, Christian Grimm, Joe G. Hollyfield, Robert E. Anderson, Matthew M. LaVail, Catherine Bowes Rickman, editors.
    "This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy."--Publisher's website.
    Also available: Print – 2014
  • 2012 Springer Protocols
    edited by Shu-Zhen Wang.
    Conditional control of gene expression in the mouse retina / Qian Ding and Lin Gan -- Generation of transgenic Xenopus using restriction enzyme-mediated integration / Mohammad Haeri and Barry E. Knox -- In vivo functional analysis of transcription factor : response element interaction using transgenic Xenopus laevis / Heithem M. El-Hodiri, Yi Pan, and Lisa E. Kelly -- Subretinal delivery and electroporation in pigmented and nonpigmented adult mouse eyes / John M. Nickerson [and others] -- In ovo eye electroporation / Teri L. Belecky-Adams, Scott R. Hudson, and Sarika Tiwari -- Targeted microinjection of synthetic mRNAs to alter retina gene expression in Xenopus embryos / Sally A. Moody -- Testing retina fate commitment in Xenopus by blastomere deletion, transplantation, and explant culture / Sally A. Moody -- Application of Cre-loxP recombination for lineage tracing of adult zebrafish retinal stem cells / Rajesh Ramachandran [and others] -- Fate tracing of neurogenin2-expressing cells in the mouse retina using CreER(TM) : LacZ / Wenxin Ma and Shu-Zhen Wang -- In vitro explant culture and related protocols for the study of mouse retinal development / Kangxin Jin and Mengqing Xiang -- In vitro biochemical assays to monitor rhodopsin function / Joshua Sammons and Alecia K. Gross -- Transfection of primary embryonic chicken retinal cells using cationic lipid / Yi-Wen Hsieh and Xian-Jie Yang -- Production of high-titer RCAS retrovirus / Run-Tao Yan and Shu-Zhen Wang -- Chick retinal pigment epithelium transdifferentiation assay for proneural activities / Shu-Zhen Wang and Run-Tao Yan -- Studying the generation of regenerated retinal neuron from muller glia in the mouse eye. / Mike O. Karl and Thomas A. Reh -- Production and transplantation of retinal cells from human and mouse embryonic stem cells / Anna La Torre [and others] -- Light-induced photoreceptor degeneration in the Retina of the zebrafish / Scott Taylor [and others] -- Microarray-based gene profiling analysis of muller glia-derived retinal stem cells in light-damaged retinas from adult zebrafish / Zhao Qin and Pamela A. Raymond -- Measuring rodent electroretinograms to assess retinal function / Molly E. Clark and Timothy W. Kraft -- Functional imaging of retinal photoreceptors and inner neurons using stimulus-evoked intrinsic optical signals / Xin-Cheng Yao and Yi-Chao Li -- Use of laser capture microdissection for analysis of retinal mRNA/miRNA Expression and DNA Methylation / Laszlo Hackler Jr [and others] -- Revealing looping organization of mammalian photoreceptor genes using chromosome conformation capture (3C) assays / Guang-Hua Peng and Shiming Chen -- Retinal transcriptome profiling by directional next-generation sequencing using 100 ng of total RNA / Matthew J. Brooks, Harsha Karur Rajasimha, and Anand Swaroop -- Exome sequencing : capture and sequencing of all human coding regions for disease gene discovery / Rinki Ratna Priya [and others] -- Determination of posttranslational modifications of photoreceptor differentiation factor NRL : focus on SUMOylation / Jerome E. Roger, Jacob Nellissery, and Anand Swaroop.
  • 2006
    [edited by] David Huang ... [et al.].
    Status: Not Checked OutLane Catalog Record
    Sect. I Imaging modalities: basic principles and interpretation -- Sect. II Macular diseases -- Sect. III Retinal vascular diseases -- Sect. IV Inflammatory and infectious diseases -- Sect. V Other retinal diseases -- Sect. VI Tumors -- Sect. VII Optic nerve disorders.
  • 2016 Karger
    volume editors, Quan Dong Nguyen, Eduardo B. Rodrigues, Michel Eid Farah, William F. Mieler, Diana V. Do.
  • 2007 Springer
    A.M. Joussen ... [et al.] (eds).
    I. Pathogenesis of retinal vascular disease -- 1 Functional anatomy, fine structure and basic pathology -- 2 Retinal vascular development -- 3 Retinal angiogenesis and growth factors -- 4 Hematopoietic stem cells in vascular development and ocular neovascularization -- 5 Inflammation as a stimulus for vascular leakage and proliferation -- 6 The neuronal influence on retinal vascular pathology -- 7 Hypoxia in the pathogenesis of retinal disease -- 8 Blood retinal barrier -- 9 Retinal blood flow -- 10 Genetic approach to retinal vascular disease -- II. General concepts in the diagnosis and treatment of retinal vascular disease -- 11 A practical guide to fluorescein angiography -- 12 Optical coherence tomography in the diagnosis of retinal vascular disease -- 13 General concepts in laser treatment for retinal vascular disease -- 14 The role of photodynamic therapy in retinal vascular disease -- 15 Cryosurgery in retinal vascular disease -- 16 Vitrectomy in retinal vascular disease: surgical principles -- 17 Treatment of rubeotic secondary glaucoma -- 18 Intravitreal injections: guidelines to minimize the risk of endophthalmitis -- III. Pathology, clinical course and treatment of retinal vascular diseases -- 19 Grading of diabetic retinopathy -- 20 Retinopathy of prematurity -- 21 Vascular occlusive disease -- 22 Vascular abnormalities -- 23 Vasculopathy after treatment of choroidal melanoma -- 24 Vasculopathies with acute systemic diseases -- 25 Inflammatory vascular disease -- 26 Hypertensive retinopathies -- 27 Sickle cell retinopathy and hemoglobinopathies -- 28 Vascular tumors of the retina.
    Also available: Print – 2007
  • 2012 Springer
    David J. Browning.
    Anatomy and Pathologic Anatomy of Retinal Vein Occlusions -- Pathophysiology of Retinal Vein Occlusions -- Genetics of Retinal Vein Occlusions -- Classification of Retinal Vein Occlusion -- Epidemiology of Retinal Vein Occlusions -- Systemic and Ocular Associations of Retinal Vein Occlusions -- The Clinical Picture and Natural History of Retinal Vein Occlusions -- Ancillary Testing in the Management of Retinal Vein Occlusions -- Ischemia and Retinal Vein Occlusions -- Posterior Segment Neovascularization in Retinal Vein Occlusion -- Anterior Segment Neovascularization in Retinal Vein Occlusion -- Macular Edema in Retinal Vein Occlusion -- Treatment of Retinal Vein Occlusions -- Retinal Vein Occlusions in the Young -- Failed and Unadopted Treatments for Retinal Vein Occlusions -- Case Studies in Retinal Vein Occlusion.
  • 2010 Springer
    Carlos Rodriguez-Galindo, Matthew W. Wilson, editors.
  • 2013 Future Med
    editor, Timothy G. Murray.
    Clinical advances and emerging treatment strategies / Timothy G. Murray -- Laboratory discoveries in retinoblastoma / Samuel K. Houston & Timothy G. Murray -- Incidence, prevalence and epidemiology / Ricardo Garza & Dan S. Gombos -- Clinical features and diagnosis of retinoblastoma / Matthew A. Cunningham & H. Culver Boldt -- Genetics of retinoblastoma and genetic counseling / Jessica Moline & Arun D. Singh -- Anesthetic considerations for children with retinoblastoma / Jacqueline Tutiven & Michael M. Vigoda -- Radiation therapy in retinoblastoma / Shiv C. Desai, Derek M. Isrow & Arnold M. Markoe -- Chemotherapy in the management of retinoblastoma / Ziad A. Khatib & Wenliang Geng -- Retinoblastoma treatment / Samuel K. Houston & Timothy G. Murray -- Treatment of extraocular and metastatic retinoblastoma / Ira J. Dunkel & Guillermo L. Chantada -- Second malignancies and other long-term effects in retinoblastoma survivors / Annette C. Moll, Jennifer van Dijk, Machteld I. Bosscha, Charlotte J. Dommering, Pim de Graaf, W. Arjenne Kors & Flora E. van Leeuwen -- Visual rehabilitation for retinoblastoma / D/ Wilkin Parke & Aaron Gold -- Retinoblastoma in the developing world / Vikas Khetan, Sabyasachi Sengupta, Fariooz P. Manjandavida & Santosh G. Honavar -- Index.
  • 2011
    Hwei Xian Leong.
    In the Adenomatous Polyposis Coli Multiple intestinal neoplasia (APCMin/+) mouse model of Familial Adenomatous Polyposis (FAP), T helper 17 (Th17) cells mediate tumor-promoting intestinal inflammation, but the underlying cause of inflammation is unknown. We find that in contrast to wild type lamina propria dendritic cells (LPDCs), which maintain intestinal tolerance by inducing TReg formation, APCMin/+ LPDCs instead induce Th17 formation. The reprogramming of LPDCs is due to a local deficit of the vitamin A metabolite, retinoic acid (RA), which results from insufficient synthesis and excessive breakdown of RA by gut associated Raldh and CYP enzymes, respectively. Exposure of APCMin/+ LPDCs to RA in vitro neutralizes their inflammatory phenotype. Treatment of mice with Liarozole, a CYP inhibitor, restores intestinal RA, eliminates Th17 inflammation and markedly reduces adenoma formation, whereas a vitamin A-deficient diet exacerbates disease. Elevated IL-17 and dysregulated vitamin A metabolism were also observed in FAP adenomas, suggesting that the same mechanism responsible for tumor-promoting intestinal inflammation in APCMin/+ mice applies to humans.
  • ScienceDirect
    edited by Lester Packer.
    Also available: Print – 1990
  • 1990 ScienceDirect
    edited by Lester Packer.
    Also available: Print – 1990
  • 2011 Springer
    Jean V. Joseph, Hitendra R.H. Patel, editors.
    Anatomical Aspects of the Extra- and Retroperitoneal Space / Ahmed E. Ghazi and Jean V. Joseph -- Essential Instruments in Laparoscopic and Robotic Surgery / Ty T. Higuchi and Matthew T. Gettman -- Upper Tract Retroperitoneal Access Techniques / Ahmed E. Ghazi and Jean V. Joseph -- Laparoscopic and Robotic Adrenalectomy / Edmund Y. Ko, Richard T. Schlinkert and Mitchell R. Humphreys -- Retroperitoneoscopic Simple and Radical Nephrectomy / Guillaume Ploussard, Andras Hoznek, Laurent Salomon, Claude C. Abbou and Alexandre de la Taille -- Laparoscopic and Robotic Partial Nephrectomy / Lori M. Dulabon and Michael D. Stifelman -- Retroperitoneal Robotic Partial Nephrectomy / James R. Porter -- Laparoscopic and Robotic Mid and Distal Ureteral Reconstructive Surgery / Alireza Moinzadeh -- Robot-Assisted Laparoscopic Nephroureterectomy / Sijo J. Parekattil, Hany N. Atalah and Li-Ming Su -- Laparoscopic Pelvic Lymphadenectomy in Prostate Cancer / Evangelos Liatsikos, Minh Do, Panagiotis Kallidonis, Iason Kyriazis and Alan McNeil, et al. -- Laparoscopic Simple Prostatectomy / Xavier Cathelineau, Rafael E. Sanchez-Salas, Eric Barret, Francois Rozet and Marc Galiano, et al. -- Extraperitoneal Laparoscopic Radical Prostatectomy / Sarah P. Psutka and Douglas M. Dahl -- Robot-Assisted Extraperitoneal Laparoscopic Prostatectomy / Thomas T. Hoang, Satya B. Allaparthi and Ingolf A. Tuerk -- Laparoendoscopic Single-Site Retroperitoneal Surgery / Michael A. White and Jihad H. Kaouk -- On the Horizon / Jean V. Joseph and Hitendra R. H. Patel.
  • 2008 Springer
    Fred Gage, Yves Christen, (eds.).
  • 2013
    Edward Bo-yi Chuong.
    The placenta plays a fundamental role supporting pregnancy in all mammals, but exhibits unexpected and striking morphological and physiological variation across species. The rapid evolutionary diversification of the mammalian placenta is hypothesized to be a product of recurrent genetic conflict between parent and offspring. In this work, I investigate the genetic basis of rapid placenta evolution by using high-throughput genomic approaches, and address three major issues in placental biology. First, given that highly conserved genes govern placental development, the molecular mechanisms underlying the rapid diversification of placental morphology have remained unresolved. Our study reveals that the genome-wide regulatory landscape of placental development is highly divergent between closely related species, strongly implicating non-coding regulatory evolution as the major force driving placental morphological diversity. Second, endogenous retroviruses (ERVs) that are normally repressed throughout the embryo are rampantly expressed in the placenta, but the biological rationale--if any-- behind this apparent paradox has been unclear. We demonstrate that species-specific ERVs serve as a major source of functional enhancers during placental development, which provides a clear mechanism where placental ERV activity may facilitate the evolutionary diversification of placental morphology. Finally, our findings suggest a novel evolutionary model where placental ERVs provide an adaptive benefit under parent-offspring conflict. Given that genetic conflict predicts rapid diversifying evolution to maintain maximal fitness, we propose that placental ERVs act to dramatically increase the developmental evolvability of the placenta by serving as a rapidly evolving, epigenetically restricted source of polymorphic regulatory elements.
  • ScienceDirect
    edited by Lawrence C. Kuo, Jules A. Shafer.
    Also available: Print – 1994
  • 2011 Springer
    Jaquelin Dudley, editor.
    Chapter 1: Overview of Retrovirology -- Chapter 2: Mechanisms of Oncogenesis by Retroviruses -- Chapter 3: Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses -- Chapter 4: Genetics of Host Resistance to Retroviruses and Cancer -- Chapter 5: Endogenous Retroviruses and Cancer -- Chapter 6: Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer -- Chapter 7: Cancers Induced by Piscine Retroviruses -- Chapter 8: The Immune Response to Oncogenic Retroviruses -- Chapter 9: Retrovirus-induced Immunodeficiency and Cancer.
  • 2016 Springer
    Mark Frankle, Scott Marberry, Derek Pupello, editors.
    Part I: History of Reverse Shoulder Arthroplasty -- Origins of Reverse Shoulder Arthroplasty and Common Misconceptions -- Part II: Biomechanics and Basic Science of Selected Leading Research Centers -- Shoulder Biomechanics: Charité University of Medicine, Berlin, Germany -- Biomechanics of the Reverse Shoulder Arthroplasty -- Reverse Shoulder Biomechanics: The Research Performed at the Foundation for Orthopaedic Research and Education (FORE) -- Design Optimization and Prosthesis Classification: Bordeaux-Merignac Sport Clinic, Bordeaux-Merignac, France -- Motion and Muscular Function after Reverse Shoulder Arthroplasty -- Biomechanics of the Normal and Reverse Shoulder -- Biomechanics of the Reverse Total Shoulder Replacement: The Hospital for Special Surgery Perspective -- Analysis of Reverse Total Shoulder Arthroplasty Biomechanics Using a Dynamic Shoulder Simulator -- Biomechanics of Reverse Shoulder Arthroplasty: Contribution of Computer Modelling -- Kinematic Analyses of Patients with Reverse Shoulder Arthroplasty -- Implant Retrieval: Drexel University, Philadelphia, Pennsylvania, USA -- Part III: Clinical Uses -- Reverse Shoulder Arthroplasty for Massive Rotator Cuff Tears Without Glenohumeral Arthritis -- Massive Rotator Cuff Arthropathy with Glenohumeral Arthritis -- Intact Rotator Cuff -- Reverse Shoulder Arthroplasty in the Setting of Proximal Humeral Fracture -- Reverse Shoulder Arthroplasty in the Setting of Scapula Fractures -- RSA with Glenoid Bone Loss -- Reverse Shoulder Arthroplasty in Patients with Preoperative Deltoid Impairment -- Reverse Total Shoulder Arthroplasty in the Setting of Infection -- Reverse Shoulder Arthroplasty in the Setting of Proximal Humeral Bone Loss -- Conversion of Failed Hemiarthroplasty to Reverse Total Shoulder Arthroplasty: Indications, Techniques, and Outcomes -- Reverse Prosthesis and the Failed Total Shoulder Arthroplasty -- Revision Reverse Total Shoulder Arthroplasty -- Proximal Humerus Tumors -- Massive Irreparable Rotator Cuff Tears: How to Rebalance the Cuff-Deficient Shoulder? -- Influence of Arm Lengthening in Reverse Shoulder Arthroplasty -- How to Handle the Humeral Side -- Rehabilitation and Activity Expectations following RSA -- Complications Associated with RSA -- Part IV: Current Industry Devices and Surgical Techniques -- Arthrex Univers ReversTM Shoulder Prosthesis -- Aston Medical Duocentric® Reversed Prosthesis: Proposition of New Glenoid Component Design to Prevent Scapular Neck Notching -- The Biomet Comprehensive© Reverse Total Shoulder System: Design Considerations and Surgical Techniques -- Depuy Synthes: Joint Reconstruction: DELTA XTEND Reverse Shoulder Prosthesis -- DJO Surgical ReverseTM Shoulder Prosthesis (RSPTM) -- Design Features and Surgical Technique of The Scultra II Reverse Prosthesis -- Evolutis UNIC Reverse Shoulder Prosthesis -- Exactech Equinoxe RTSA Platform Shoulder System Design Rationale -- FH Orthopedics Arrow Universal Shoulder Prosthesis -- Verso® Stemless Bone Preserving Reverse Geometry Total Shoulder Replacement: (Innovative Design Orthopaedics Ltd.) -- The Integra® TitanTM Reverse Shoulder System -- The SMR ® Shoulder System of Lima Corporate -- Mathys Affinis® Inverse -- The Bayley/Walker Prosthesis: Stanmore Implants Worldwide -- Tornier Aequalis AscendTM Flex Convertible Shoulder System -- Zimmer Reverse Total Shoulder Arthroplasty -- Part V: Economic Value -- Value and Reverse Total Shoulder Arthroplasty: The Foundation for Orthopaedic Research and Education Perspective -- Value and Reverse Total Shoulder Arthroplasty: The Boston Shoulder Institute Perspective.
  • 2006 Springer
    edited by Gail Skowron, Richard Ogden ; foreword by Joep M.A. Lange.
    Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren -- Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler -- Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens -- Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels -- Nucleotide analogs / Craig J. Hoesley -- Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters -- Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard ... [et al.] -- Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt -- Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis -- Mitochondrial toxicity and lipodystrophy / Grace McComsey -- Nevirapine / David Asmuth and Richard Pollard -- Efavirenz / Graeme J. Moyle and Brian Conway -- Delavirdine / Brian Conway -- Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich -- Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha -- New reverse transcriptase inhibitors in development / Rudi Pauwels -- Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande.
  • 2010 CRCnetBASE
    William J. Rea, Kalpana Patel.
    Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.
  • 2015 CRCnetBASE
    William J. Rea, Kalpana Patel.
  • 2010
    Andre Gallardo, Valerie Berry.
  • 2007
    editor, Kenneth Ibsen ; co-editor, Nandan Bhatt.
    Status: Not Checked OutLane Catalog Record
  • 2007
    Mitchell H. Rosner, Andrew E. Lazar.
    Status: Not Checked OutLane Catalog Record
  • 2010
    Mitchell H. Rosner.
    Status: Not Checked OutLane Catalog Record
  • 2006
    John S. Lazo, Bruce R. Pitt, Joseph C. Glorioso III.
    Status: Not Checked OutLane Catalog Record
  • 2015 Springer
    William Amestoy.
  • 2016 (14th ed.) AccessMedicine
    13th ed., 2014 AccessMedicine
    Levinson, Warren.
    Also available: Print – 2006-<2016>
  • 2016 (25th ed.) AccessMedicine
    24th ed., 2012 AccessMedicine
    Barrett, Kim E.; Ganong, William F.
    Also available: Print – 1985-<2016>
  • 2013 Ovid
    [edited by] Mark R. Brinker.
  • 2008
    [edited by] Mark D. Miller ; associate editor-in-chief Jennifer A. Hart.
    Basic sciences / Mark R. Brinker, Daniel P. O'Connor -- Pediatric orthopaedics / Todd A. Milbrandt, Daniel J. Sucato -- Sports medicine / Joshua A. Baumfeld, Jennifer A. Hart, Mark D. Miller -- Adult reconstruction / Edward J. McPherson -- Disorders of the foot and ankle / Gregory J. Roehrig, MD ... [et al.] -- Hand, upper extremity, and microvascular / Lance M. Brunton, A. Bobby Chhabra -- Spine / William C. Lauerman, Bradley Graw -- Pathology / Frank J. Frassica, Deborah A. Frassica, Edward F. McCarthy -- Rehabilitation: gait, amputations, prosthetics, orthotics / Frank A. Gottschalk -- Trauma / James P. Stannard ... [et al.] -- Anatomy / Franklin D. Shuler -- Principles of practice and statistics / S. Raymond Golish, Mark DeHart.
  • 2016 Ovid
    Walter Huda.
    "This book remains focused on imaging using X-rays (i.e., projection radiography, fluoroscopy, and CT), as well as nuclear medicine, ultrasound, and MR"--Provided by publisher.
  • 2012 Ovid
    Walter Huda.
    X-ray production -- X-ray interactions -- Projection radiography I -- Projection radiography II -- Computed tomography -- Image quality -- Radiobiology/patient dosimetry -- Radiation protection -- Nuclear medicine -- Ultrasound -- Magnetic resonance.
    Also available: Print – 2010
  • 1967
    [by] Marjorie A.C. Young.
    [1] What people know, believe, and do about health. -- [4] Patient education. -- [6] School health education.
  • 2012 Springer
    Nona T. Colburn.
    The Musculoskeletal System -- Mediators of Rheumatic Pathology -- Immunity -- Genetics -- Rheumatoid Arthritis -- Psoriatic Arthritis -- Systemic Lupus Erythematosus (SLE) -- Arthritis Associated with Calcium-Containing Crystals -- Gout -- Vasculitides -- Systemic Sclerosis and Related Syndromes -- Sjögren's Syndrome -- Behcet's Disease -- Relapsing Polychondritis -- Antiphospholipid Syndrome -- Adult Still's Disease -- Therapeutic Injections for Rheumatic Diseases -- Nonsteroidal Anti-inflammatory Drugs -- Corticosteroids -- Disease-Modifying Antirheumatic Drugs -- Cytotoxic and Immunoregulatory Agents -- Biologic Agents -- Osteoporosis -- Metabolic Bone Disorders -- Paget's Disease of Bone -- Osteonecrosis -- Hypertrophic Osteoarthropathy -- Storage and Deposition Diseases -- Amyloidoses -- The Autoinflammatory Diseases.
  • 2006 Springer
    Gamal Mostafa, Lamont Cathey, Frederick Greene, editors.
  • 2005 NAP
    Committee on Reviewing the HIVNET 012 Perinatal HIV Prevention Study, Board on Population Health and Public Health Practice, Institute of Medicine of the National Academies.
  • Rand
    Lee H. Hilborne, Beatrice Alexandra Golomb.
    v. 1. Infectious diseases.
  • 2015 Ovid
    [edited by] Kenneth C. Chern, MD, Michael A. Saidel.
    Fundamentals / Michael A. Saidel, Ashley Rohr -- Embryology and anatomy / Megan E. Collins -- Optics / Kenneth Chern -- Neuro-ophthalmology / Jeffrey Nichols -- Pediatrics and strabismus / Megan E. Collins -- Plastics / Marcus J. Ko, Wendy W. Lee -- Pathology / Marcus Marcet -- Uveitis / David M. Hinkle -- Glaucoma / Shuchi Patel -- Cornea / Kenneth Chern and Michael Saidel -- Lens/cataract / Kenneth Chern and Edward Koo -- Retina and vitreous / Alok Bansal, Rahul Khurana and Louis Chang.
  • 2006 Springer
    edited by Jean-Marie Buerstedde and Shunichi Takeda.
    Ch. 1. DT40 gene disruptions: a how-to for the design and the construction of targeting vectors / Hiroshi Arakawa and Jean-Marie Buerstedde -- Ch. 2. Immunoglobulin gene conversion or hypermutation: That's the question / Jean-Marie Buerstedde and Hiroshi Arakawa -- Ch. 3. Genome resources for the DT40 community / Randolph B Caldwell and Andrzej M. Kierzek -- Ch. 4. Chromosome engineering in DT40 cells and mammalian centromere function / William R.A. Brown ... [et al.] -- Ch. 5. Function of recQ family helicase in genome stability / Masayuki Seki, Shusuke Tada and Takemi Enomoto -- Ch. 6. Genetic analysis of apoptotic execution / Sandrine Ruchaud ... [et al.] -- Ch. 7. The DT40 system as a tool for analyzing kinetochore assembly / Masahiro Okada, Tesuya Hori and Tatsuo Fukagawa -- Ch. 8. Analysing the DNA damage and replication checkpoints in DT40 cells / Michael D Rainey, George Zachos, and David AF Gillespie -- Ch. 9. Using DT40 to study clathrin function / Frank R. Wettey and Antony P. Jackson -- Ch. 10. Genetic analysis OF B cell signaling / Hisaaki Shinohara and Tomohiro Kurosaki -- Ch. 11. DT40 mutants: a model to study transcriptional regulation of B cell development and function / Jukka Alinikula, Olli Lassila and Kalle-Pekka Nera -- Ch. 12. Transcription and RNA processing factors play complex roles IN DT40 cells / Stephanie Bush and James L. Manley -- Ch. 13. Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions / Hidehiko Kikuchi ... [et al.] -- Ch. 14. Analysis of gene expression, copy number and palindrome formation with a DT40 enriched cDNA Microarray / Paul E. Neima ... [et al.] -- Ch. 15. Analysis of DNA replication damage bypass and its role in immunoglobulin repertoire development / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 16. The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 17. Calcium signaling, ion channels and more / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- Ch. 18. Phenotypic analysis of cellular responses to DNA damage / Helfrid Hochegger and Shunichu Takeda -- Ch. 19. ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells / Ken-ichi Yamamoto, Masahiko Kobayashi and Hiroko Shimizu -- METHOD 1. Stable transfection of DT40 / Julian E. Sale -- METHOD 2. Basic cell culture conditions / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 3. Excision of floxed-DNA sequences by transient induction of Mer-Cre-Mer / Hiroshi Arakawa -- METHOD 4. Immunoglobulin gene conversion and hypermutation assay by FACS / Hiroshi Arakawa -- METHOD 5. Target screening by PCR / Hiroshi Arakawa -- METHOD 6. Mitotic index determination by flow cytometry / David AF Gillespie and Mark Walker -- METHOD 7. Centrifugal elutriation as a means of cell cycle phase separation and synchronization / David AF Gillespie and Catarina Henriques -- METHOD 8. Preparation of genomic DNA for microarray-based comparative genome hybridization / Robert Kimmel, Amalia Icreverzi, Paul Neiman -- METHOD 9. Analysis of cellular Mg2+ in DT40 cells / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- METHOD 10. Transient transfection of DT40 / Roger Franklin & Julian E. Sale -- METHOD 11. Retroviral transduction of DT40 / Felix Randow & Julian E. Sale -- METHOD 12. Colony survival assay / Laura. J. Simpson & Julian E. Sale -- METHOD 13. Subcloning DT40 by limiting dilution / Jean-Marie Buerstedde -- METHOD 14. Subnuclear immunofluorescence / Dávid Szüts & Julian E. Sale -- METHOD 15. Sister chromatid exchange assay / Laura J. Simpson & Julian E. Sale -- METHOD 16. 2D cell cycle analysis / Roger Franklin & Julian E. Sale -- METHOD 17. Purification of tap-tagged proteins by two-step pull down from DT40 cells / Hiroyuki Kitao and Minoru Takata -- METHOD 18. Synchronization of cells / Eiichiro Sonoda -- METHOD 19. Tranfection of DT40 cells / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 20. Luciferase reporter assay / Frank R. Wettey and Antony P. Jackson -- METHOD 21. Indirect immunofluorescence microscopy / Frank R. Wettey and Antony P. Jackson -- METHOD 22. Quantification of receptor-mediated endocytosis / Frank R. Wettey and Antony P. Jackson -- METHOD 23. Measurement of DNA synthesis and strand breaks using alkaline sucrose density gradient centrifugation / Kouichi Yamada and Jun Takezawa -- METHOD 24. Fractionation of nuclear and cytoplasmic proteins from DT40 cell lines / Yan-Dong Wang and Randolph B Caldwell.
  • 2012 Springer
    Chris D. Geddes, editor.
  • 2010 Springer
    Chris D. Geddes, editor.
  • 2014 Springer
    Robert G. Marx, editor.
    Although anterior cruciate ligament (ACL) reconstruction has a high success rate, a substantial number of patients are left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique provides detailed strategies for planning and executing revision ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons cover the diagnosis of failed ACL reconstruction, patient evaluation, preoperative planning for revision ACL surgery, and complex technical considerations.
  • 2007 Springer
    Pierre Le Béguec, Hans-Peter Sieber ; introduction by Erwin W. Morscher.
  • 2005 Springer
    James V. Bono, Richard D. Scott, editors ; forewords by Chitranjan S. Ranawat and Roderick H. Turner.
  • 2014 Cambridge
    edited by Laurence J. Kirmayer, Robert Lemelson, Constance A. Cummings.
  • 1977-
    by Daniel E. Schneider.
    Status: Not Checked OutLane Catalog Record
  • 1976-
    by C. Keith Wilbur.
    Status: Not Checked OutLane Catalog Record
  • 2013
    This report is being released in conjunction with the Robert Wood Johnson Foundation's Care About Your Care initiative, which is devoted to improving care transitions when people leave the hospital. It looks at the issue of readmissions in two ways: by the numbers and through the eyes of the people who live them.
  • George Paxinos ... [et al.].
  • 2009 NICE
    The summary of the published clinical guideline on Rheumatoid arthritis. It links to the published guidance and key documents.
  • 2012 Springer
    Alan Ebringer.
  • 2009 ClinicalKey
    [edited by] Marc C. Hochberg [and others].
    This reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It provides the latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures-disease activity, joint assessment, imaging, and more-for expert diagnosis and monitoring of disease progression.
  • 2011 Springer
    Efim Benenson.
    1. Diagnostic Training and Rheumatology Trees -- 2. Explanations of Figures and Case Reports with Individual Therapeutic Options -- 3. Index of Figures (Fig.) and CS with Syndromes (for Self-assessment) -- Appendix: Index of the Solutions to the Syndromes and Diagnostics (for Rapid Diagnosis).
  • 2010 Springer
    José António Pereira da Silva, Anthony D. Woolf.
    The Importance of Rheumatic Diseases, The Satisfaction Of Caring For These Patients -- Pain, Disease and Suffering an Integrated Perspective -- The Structure and Function of the Musculoskeletal System Sources of Pain -- Diagnostic Strategy the Main Syndromes in Rheumatology -- The Standard Enquiry in Rheumatology -- The General Clinical Examination -- Regional Syndromes Neck Pain -- Regional Syndromes The Painful Shoulder -- Regional Syndromes The Elbow And Forearm -- Regional Syndromes the Wrist and Hand -- Regional Syndromes Low Back Pain -- Regional Syndromes The Hip -- Regional Syndromes The Knee -- Regional Syndromes the Foot and Ankle -- Generalized Pain Syndrome Fibromyalgia Osteoarthritis -- Inflammatory Arthritides Diagnostic Strategies -- Monoarthritis -- Chronic, Additive, Symmetrical, Peripheral Polyarthritis -- Chronic, Asymmetrical Oligo- Or Polyarthritis -- Chronic Proximal Oligoarthritis -- Arthritis of the Shoulder and Pelvic Girdles Polymyalgia Rheumatica -- Acute Oligo- or Polyarthritis Febrile Arthritis Arthritis with Mucocutaneous Manifestations -- Inflammatory Low Back Pain -- Systemic Syndromes Connective Tissue Diseases Vasculitis Raynaud's Phenomenon -- Osteoporotic Syndrome Osteoporosis -- Bone Syndrome Bone Diseases -- Rheumatic Symptoms in Children and Adolescents -- Treating Rheumatic Diseases, General Principles -- Drugs Commonly Used in Rheumatic Diseases.
  • 2015 ClinicalKey
    [edited by] Marc C. Hochberg, Alan J. Silman, Josef S. Smolen, Michael E. Weinblatt, Michael H. Weisman.
    Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
  • 2011 Springer
    Efim Benenson.
    1. Articular disorders -- 2. Diseases of the spine -- 3. Soft-tissue rheumatism and related disorders -- 4. Regional arthrological and musculoskeletal syndromes -- 5. Paraneoplastic syndromes (PNS) in rheumatology -- 6. Algorithms in articular and musculoskeletal disorders: integrated diagnostic screening program: staged diagnostics -- 7. Algorithms in arthrological and musculoskeletal disorders -- 8. General symptoms (BVAS = maximum of 3 out of 63 points) -- 9. Involvement of connective tissue structures -- 10. System-/organ involvement -- 11. (Auto) immunological phenomena and serological diagnostics -- 12. Treatment-induced and associated conditions and diseases -- 13. Integrated diagnostic screening program staged diagnostics -- 14. Algorithms for connective tissue disease and vasculitis.
  • 2007 Springer
    Stilianos Kountakis, Metin Önerci (eds.).
  • 2009 Springer
    edited by F.J. Stucker ... [et al.].
  • 2012 ClinicalKey
    Bahman Guyuron.
    Surgical Anatomy and Physiology of the Nose -- Patient Assessment for Rhinoplasty -- Dynamics of Rhinoplasty -- Primary Rhinoplasty -- Variations in Nasal Osteotomy : Consequences and Technical Nuances -- Tip Sutures -- Achieving Optimal Tip Projection -- Elongation of the Short Nose -- Correction of the Overprojected Nose -- Rhinoplasty on Patients with Cleft Lip Nose Deformity -- Correction of Alar Rim Deformities -- Alar Base Surgery -- Controlling the Nostril Size -- Rhinoplasty and Time Element -- Correcting the Nasal Deformity Resulting from Cocaine Insufflation -- Rhinoplasty in Patients with Thick Skin -- Correcting Deviated Noses, Septoplasty and Turbinectomy -- Rhinoplasty and Ethnicity -- Secondary Rhinoplasty -- Prevention and Management of Rhinoplasty Complications -- Rhinogenic Migraine Headaches.
  • 2008 Springer
    Erica R. Thaler, David W. Kennedy, editors.
  • 2015 Springer Protocols
    edited by David A. Jans, Monash University, Melbourne, VIC, Australia, Reena Ghildyal, University of Canberra, ACT, Australia.
    Classification and evolution of human rhinoviruses / Ann C. Palmenberg and James E. Gern -- Nested-RT-PCR and multiplex RT-PCR for diagnosis of rhinovirus infection in clinical samples / Xuelian Yu and Reena Ghildyal -- Molecular identification and quantification of human rhinoviruses in respiratory samples / Wai-Ming Lee ... [et al.] -- Molecular genotyping of human rhinovirus by using PCR and sanger sequencing / Wei Wang ... [et al.] -- Growth of human rhinovirus in H1-HeLa cell suspension culture and purification of virions / Wai-Ming Lee ... [et al.] -- Propagation of rhinovirus-C strains in human airway epithelial cells differentiated at air-liquid interface / Shamaila Ashraf, Rebecca Brockman-Schneider, and James E. Gern -- Infectivity assays of human rhinovirus-A and -B serotypes / Wai-Ming Lee ... [et al.] -- Application of FCS in studies of rhinovirus receptor binding and uncoating / Shushan Harutyunyan ... [et al.] -- Capillary electrophoresis, gas-phase electrophoretic mobility molecular analysis, and electron microscopy : effective tools for quality assessment and basic rhinovirus research / Victor U. Weiss ... [et al.] -- Proteases of human rhinovirus : role in infection / Lora M. Jensen ... [et al.] -- Protocol to express and isolate HRV16 3C protease for use in protease assays / Lora M. Jensen, Erin J. Walker, and Reena Ghildyal -- Reverse genetics system for studying human rhinovirus infections / Wai-Ming Lee ... [et al.] -- Reverse genetic engineering of the human rhinovirus serotype 16 genome to introduce an antibody-detectable tag / Erin J. Walker, Lora M. Jensen, and Reena Ghildyal -- Mouse models of rhinovirus infection and airways disease / Nathan W. Bartlett, Aran Singanayagam, and Sebastian L. Johnston.
  • 2005 Springer
    edited by Ed Manser.
  • 2012 Springer Protocols
    edited by Francisco Rivero.
    Historical overview of Rho GTPases -- Rho GTPases: Deciphering the evolutionary history of a complex protein family -- Biochemical assays to characterize Rho GTPases -- How to analyze bacterial toxins targeting Rho GTPases -- Assessing ubiquitylation of Rho GTPases in mammalian cells -- Posttranslational lipid modification of Rho family small GTPases -- Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases -- A quantitative fluorometric approach for measuring the interaction of RhoGDI with membranes and Rho GTPases -- Rho GTPases and cancer cell transendothelial migration -- Quantitative and robust assay to measure cell-cell contact assembly and maintenance -- Rho GTPase knockout induction in primary keratinocytes from adult mice -- Rho GTPase techniques in osteoclastogenesis -- Assessment of Rho GTPase signaling during neurite outgrowth -- Assessment of the role for Rho family GTPases in nadph oxidase activation -- Multiplex imaging of Rho family GTPase activities in living cells -- FRET-based imaging of rac and cdc42 activation during fc-receptor-mediated phagocytosis in macrophages -- High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors -- Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format -- Use of phage display for the identification of molecular sensors specific for activated Rho -- Identification of new interacting partners for atypical Rho GTPases: A silac-based approach -- Using zebrafish for studying Rho GTPases signaling in vivo -- Analysis of Rho GTPase function in axon pathfinding using caenorhabditis elegans -- Protocol for ex vivo incubation of drosophila primary post-embryonic haemocytes for real-time analyses -- Analysis of Rho GTPase activation in saccharomyces cerevisiae -- Assaying Rho GTPase-dependent processes in dictyostelium discoideum -- FRAP-based analysis of Rho GTPase-dependent polar exocytosis in pollen tubes.
  • 2010 Springer
    Kenneth van Golen, editor.
  • Frank L. Grzyb ; foreword by Robert C. Rubel.
    "During the Civil War, Union soldiers and Confederate prisoners convalesced in a general army hospital in Portsmouth Grove, Rhode Island. This study details experiences of those who received and provided care, exploring the barbarities of medicine, daily routine, role of citizens, later adventures of former patients/staff, and final resting places of those who died on the grounds"--Provided by publisher.
  • 2014 CRCnetBASE
    edited by Alain Cuerrier, Kwesi Ampong-Nyarko.
    Chapter 1. Taxonomy of Rhodiola rosea L., with special attention to molecular analyses of Nunavik (Québec) populations / Alain Cuerrier, Mariannick Archambault, Michel Rapinski, and Anne Bruneau -- Chapter 2. Ethnobotany and conservation of Rhodiola species / Alain Cuerrier, Youri Tendland, and Michel Rapinski -- Chapter 3. Phytochemistry of Rhodiola rosea / Fida Ahmed, Vicky Filion, Ammar Saleem, and John T. Arnason -- Chapter 4. Cultivation of Rhodiola rosea in Europe / Bertalan Galambosi -- Chapter 5. Rhodiola rosea cultivation in Canada and Alaska / Kwesi Ampong-Nyarko -- Chapter 6. Diseases of wild and cultivated Rhodiola rosea / Sheau-Fang Hwang, Stephen E. Strelkov, Kwesi Ampong-Nyarko, and Ron J. Howard -- Chapter 7. Biotechnology of Rhodiola rosea / Zsuzsanna György -- Chapter 8. Pharmacological activities of Rhodiola rosea / Fida Ahmed, Steffany A.L. Bennett, and John T. Arnason -- Chapter 9. Evidence-based efficacy and effectiveness of Rhodiola SHR-5 extract in treating stress- and age- associated disorders / Alexander Panossian and Georg Wikman -- Chapter 10. Rhodiola rosea in psychiatric and medical practice / Patricia L. Gerbarg, Petra A. Illig, and Richard P. Brown -- Chapter 11. Toxicology and safety of Rhodiola rosea / Hugh Semple and Brandie Bugiak -- Chapter 12. Commercialization of Rhodiola rosea / Nav Sharma and Raimar Loebenberg.
  • 2015 Springer Protocols
    edited by Beata Jastrzebska.
    G protein-coupled receptor rhodopsin : a historical perspective / Lukas Hofmannand Krzysztof Palczewski -- Rhodopsin purification from dark-adapted bovine retina / Elise Blankenship and David T. Lodowski -- Mammalian expression, purification, and crystallization of rhodopsin variants / Daniel Mattle [and 4 others] -- Imaging of rhodopsin crystals with two-photon microscopy / Grazyna Palczewska and David Salom -- Functional stability of rhodopsin in a bicelle system : evaluating G protein activation by rhodopsin in bicelles / Ali I. Kaya, T.M. Iverson, and Heidi E. Hamm -- Rhodopsin-arrestin-1 interaction in bicelles / Qiuyan Chen [and 7 others] -- Detection of structural waters and their role in structural dynamics of rhodopsin activation / Liwen Wang and Mark R. Chance -- Probing conformational changes in rhodopsin using hydrogen-deuterium exchange coupled to mass spectrometry / Tivadar Orban and Yaroslav Tsybovsky -- Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange / David T. Lodowski and Masaru Miyagi -- Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium NMR spectroscopy / Andrey V. Struts [and 3 others] -- Sequential structural changes in rhodopsin occurring upon photoactivation / Naoki Kimata [and 4 others.] -- Dynamic single-molecule force spectroscopy of rhodopsin in native membranes / Paul S.-H. Park and Daniel J. Müller -- High-resolution atomic force microscopy imaging of Rhodopsin in rod outer segment disk membranes / Patrick D. Bosshart, Andreas Engel, and Dimitrios Fotiadis -- Detection of rhodopsin dimerization in situ by PIE-FCCS, a time-resolved fluorescence spectroscopy / Adam W. Smith -- Oligomeric state of rhodopsin within rhodopsin-transducin complex probed with succinylated concanavalin A / Beata Jastrzebska -- Quantification of arrestin-rhodopsin binding stoichiometry / Ciara C.M. Lally and Martha E. Sommer -- Rhodopsin transient complexes investigated by systems biology approaches / Daniele Dell'Orco -- Three-dimensional architecture of murine rod cilium revealed by cryo-EM / Theodore G. Wenseland Jared C. Gilliam -- Monitoring of rhodopsin trafficking and mistrafficking in live photoreceptors / Kerrie H. Lodowski and Yoshikazu Imanishi -- Measurements of rhodopsin diffusion within signaling membrane microcompartments in live photoreceptors / Mehdi Najafi and Peter D. Calvert -- Kinetics of rhodopsin's chromophore monitored in a single photoreceptor / Leopold Adler IV [and 3 others] -- Supplementation with vitamin A derivatives to rescue vision in animal models of degenerative retinal diseases / Lindsay Perusek, Akiko Maeda, and Tadao Maeda -- Sustained delivery of retinoids to prevent photoreceptor death / Peter H. Tang and Rosalie K. Crouch -- High-throughput screening assays to identify small molecules preventing photoreceptor degeneration caused by the rhodopsin P23H mutation / Yuanyuan Chen and Hong Tang -- Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin / Brian P. Rossmiller, Renee C. Ryals, and Alfred S. Lewin.
  • 2006
    György Buzsáki.
    Structure defines function -- Diversity of cortical functions is provided by inhibition -- Windows on the brain -- A system of rhythms -- Synchronization by oscillation -- The brain's default state -- Perturbation of the default patterns by experience -- The gamma buzz -- Perceptions and actions are brain state-dependent -- Oscillations in the "other cortex" -- Coupling of systems by oscillations -- Tough problems.
  • 2010 Springer
    Fenyong Liu, Sidney Altman, editors.
    History of RNase P and Overview of Its Catalytic Activity -- The Evolution of RNase P and Its RNA -- Over a Decade of Bacterial Ribonuclease P Modeling -- Structural Studies of Ribonuclease P -- Folding of Bacterial RNase P RNA -- Kinetic Mechanism of Bacterial RNase P -- Roles of Metal Ions in RNase P Catalysis -- Challenges in RNase P Substrate Recognition: Considering the Biological Context -- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives -- Eukaryote RNase P and RNase MRP -- RNase P from Organelles -- Human RNase P and Transcription -- RNase P as a Drug Target -- Ribonuclease P as a Tool.
  • 2011 Springer
    Allen W. Nicholson (ed.).
  • pt. A-B, 2001. ScienceDirect
    pt. B ScienceDirect
    edited by Allen W. Nicholson.
    Also available: Print – pt. A-B, 2001.
  • 2012 Springer Protocols
    edited by Julie A. Douthwaite and Ronald H. Jackson.
    Ribosome display : a perspective / Andreas Plückthun -- Preparation and testing of E. coli S30 in vitro transcirption translation extracts / James F. Zawada -- Eurkaryotic ribosome display selection using rabbit reticulocyte lysate / Julie A Douthwaite -- Stabilized ribosome display for in vitro selection / Shuta Hara [and others] -- Eukaryotic ribosome display with in situ DNA recovery / Mingyue He [and others] -- mRNA display using covalent coupling of mRNA to translated proteins / Rong Wang, Steve W. Cotten, and Rihe Liu -- SNAP display : in vitro rotein evolution in microdroplets / Miriam Kaltenbach and Florian Hollfelder -- cDNA display : rapid stabilization of mRNA display / Shingo Ueno and Naoto Nemoto -- Optimisation of antibody affinity by ribosome display using error-prone or site-directed mutagenesis / Leeanne Lewis and Chris Lloyd -- Affinity maturation of phage display antibody populations using ribosome display / Maria A. Groves and Adrian A. Nickson -- Evolution of protein stability using ribosome display / Andrew Buchanan -- Selection of lead antibodies from naive ribosome display antibody libraries / Peter Ravn -- Evolution of disulfide-rich peptide aptamers using cDNA display / Yuki Mochizuki and Naoto Nemoto -- Peptide screening using PURE ribosome display / Hiroyuki Ohashi [and others] -- Rapid selection of high-affinity binders using ribosome display / Birgit Dreier and Andreas Plückthun -- mRNA display-based selections using synthetic peptide and natural protein libraries / Steve W. Cotten [and others] -- Identification of candidate vaccine genes using ribosome display / Liancheng Lei -- Ribosome display for the selection of Sac7d scaffolds / Barbara Mouratou [and others] -- Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers / Patrick C. Reid [and others] -- Update on pure translation display with unnatural amino acid incorporation / R. Edward Watts and Anthony C. Forster -- In vitro selection of unnatural cyclic peptide libraries via mRNA display / Zhong Ma and Matthew C.T. Hartman -- Optimization of CAT-354, a therapeutic antibody directed against interleukin-13, using ribosome display / George Thom and Ralph Minter -- Affinity maturation and functional dissection of a humanised anti-RAGE monoclonal antibody by ribosome display / Simon E. Hufton.
  • ScienceDirect
    edited by Harry F. Noller, Jr., Kivie Moldave.
    Also available: Print – 1988
  • 2011 Springer
    Marina V. Rodnina, Wolfgang Wintermeyer, Rachel Green, editors.
    The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
  • 2014 ScienceDirect
    edited by Donald H. Burke-Aguero.
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers research methods in biomineralization scienceContains sections on such topics as riboswitch discovery and valid.
  • 2015 ScienceDirect
    edited by Donald H. Burke-Agüero.
  • 2012 Springer Protocols
    edited by Jörg S. Hartig.
    Introduction -- Characterization of hammerhead ribozyme reactions -- Mechanistic analysis of the hepatitis delta virus (HDV) ribozyme: Methods for RNA preparation, structure mapping, solvent isotope effects, and co-transcriptional cleavage -- Kinetic characterization of hairpin ribozyme variants -- Characterization of RNase p rna activity -- Group I intron ribozymes -- Kinetic characterization of group II intron folding and splicing -- Mechanism and distribution of glmS ribozymes -- Structure-based search and in vitro analysis of self-cleaving ribozymes -- Discovery of rna motifs using a computational pipeline that allows insertions in paired regions and filtering of candidate sequences -- Crystallographic analysis of small ribozymes and riboswitches -- Functional dynamics of RNA ribozymes studied by NMR spectroscopy -- Deoxyribozyme-based, semisynthetic access to stable peptidyl-trnas exemplified by tRNA(Val) carrying a macrolide antibiotic resistance peptide -- Probing functions of the ribosomal peptidyl transferase center by nucleotide analog interference -- Single molecule fret characterization of large ribozyme folding -- Metal ion-RNA interactions studied via multinuclear NMR -- Analysis of catalytic RNA structure and function by nucleotide analog interference mapping -- In vitro selection of metal ion-selective dnazymes -- Selecting allosteric ribozymes -- Screening effective target sites on mRNA: A ribozyme library approach -- A computational approach to predict suitable target sites for trans-acting minimal hammerhead ribozymes -- Targeting mRNAs by engineered sequence-specific RNase p ribozymes -- Target-induced SOFA-HDV ribozyme -- Ribozyme-mediated trans insertion-splicing into target RNAs -- Developing fluorogenic RNA-cleaving dnazymes for biosensing applications -- Development of trainable deoxyribozyme-based game playing automaton -- Rational design and tuning of ribozyme-based devices -- In vivo screening of ligand-dependent hammerhead ribozymes -- Flexizymes as a tRNA acylation tool facilitating genetic code reprogramming.
  • 2013 Springer Protocols
    edited by Yinong Yang.
    Rice artificial hybridization for genetic analysis / Xueyan Sha -- Fluorescence in situ hybridization techniques for cytogenetic and genomic analyses / Jason G. Walling, Wenli Zhang, and Jiming Jiang -- Generation of rice mutants by chemical mutagenesis / Thomas H. Tai -- TILLING and ecotilling for rice / Jennifer L. Cooper [and others] -- Functional characterization of rice genes using a gene-indexed T-DNA insertional mutant population / Ki-Hong Jung and Gynheung An -- QTL analysis and map-based cloning of salt tolerance gene in rice / Ji-Ping Gao and Hong-Xuan Lin -- Site-specific gene integration in rice / Vibha Srivastava -- Transcriptome profiling analysis using rice oligonucleotide microarrays / Ki-Hong Jung and Pamela C. Ronald -- Cloning of small RNAs for the discovery of novel microRNAs in plants / Guru Jagadeeswaran and Ramanjulu Sunkar -- Global identification of small RNA targets in plants by sequencing sliced ends of messenger RNAs / Yong-Fang Li and Ramanjulu Sunkar -- Artificial microRNAs for specific gene silencing in rice / Norman Warthmann [and others] -- Rice proteomic analysis : sample preparation for protein identification / Ganesh Kumar Agrawal [and others] -- Quantification of jasmonic and salicylic acids in rice seedling leaves / Kyoungwon Cho [and others] -- Analysis of insect-induced volatiles from rice / Nan Zhao [and others] -- Phenotypic and physiological evaluation for drought and salinity stress responses in rice / Utlwang Batlang [and others] -- Phenotypic, physiological, and molecular evaluation of rice chilling stress response at the vegetative stage / Benildo G. de los Reyes [and others] -- Analysis of rice root hair morphology using cryo-scanning electron microscopy / Zhiming Yu -- Inoculation and virulence assay for bacterial blight and bacterial leaf streak of rice / Bing Yang and Adam Bogdanove -- Inoculation and scoring methods for rice sheath blight disease / Yulin Jia [and others] -- Molecular approaches to improve rice abiotic stress tolerance / Junya Mizoi and Kazuko Yamaguchi-Shinozaki -- Molecular strategies to improve rice disease resistance / Emily E. Helliwell and Yinong Yang -- Molecular strategies to engineer transgenic rice seed compartments for large-scale production of plant-made pharmaceuticals / Trevor Greenham and Illimar Altosaar.
  • 2016 ClinicalKey
    [edited by] Todd E. Rasmussen, MD, FACS, Colonel, USAF MC, Director, U.S. Combat Casualty Care Research Program, Fort Dietrick, Maryland, Harris B. Shumacker, Jr. Professor of Surgery, The Norman M. Rich Department of Surgery, Uniformed Services University of the Health Sciences, Bethesda, Maryland, Attending Vascular & Trauma Surgeon, Veterans Administration Medical Center & University of Maryland Shock Trauma Center, Baltimore, Maryland, Nigel R.M. Tai, QHS, MS, FRCS(Gen), Colonel, L/RAMC, Clinical Director, Trauma Services, Royal London Hospital, Barts Health NHS Trust, London, United Kingdom, Senior Lecturer, Academic Department of Military Surgery and Trauma, Royal Centre for Defense Medicine, Birmingham, United Kingdom, Consultant Surgeon, 16 Medical Regiment, Colchester, Essex, United Kingdom.
    Published in association with the Society for Vascular Surgery (SVS), the newly updated edition of Rich's Vascular Trauma draws on civilian and military authorities from around the world to offer comprehensive and up-to-date coverage of the management of vascular injury. Anatomic patterns of vascular trauma including extremity, torso and cervical injury are reviewed in detail, including the latest techniques to manage non-compressible torso hemorrhage. You'll have access to all of the current innovations across the broad spectrum of vascular trauma, presented in a well-organized fashion that allows you to quickly hone-in on the most important issues in patient care and management.
  • 2012 Springer
    Nicholas J. Mantis, editor.
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • 2014 Springer
    Sean P. Gaine, Robert Naeije, Andrew John Peacock, editors.
    "This comprehensive book describes the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. It continues with a detailed examination of the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease. Right heart dysfunction caused by pulmonary hypertension is discussed in particular detail. The Right Heart brings together a distinguished group of contributors to discuss the advances in the topic that have occurred over the last few years and provides a concise and up-to-date resource for clinicians by compiling this comprehensive state-of-the-art text on the subject, the Editors have created an indispensable reference for future work by those interested in the cardiopulmonary circuit. This book will appeal to respiratory physicians, cardiologists and intensivists, all of whom will share the Editors' belief that the right heart is fundamental to integrated cardiopulmonary performance."
  • 2008 Springer
    Ronald Eisenberg and Alexander Margulis.
  • Annie E. Casey Foundation.
  • 2012 Springer
    Massimo Chessa, Alessandro Giamberti, editors ; foreword by Gary D. Webb.
    Introduction / Massimo Chessa and Alessandro Giamberti -- Anatomy of Tetralogy of Fallot / Carla Frescura and Gaetano Thiene -- Genetics / M. Cristina Digilio, Bruno Dallapiccola and Bruno Marino -- Stem Cells and the Right Ventricle / Luigi Anastasia and Marco Piccoli -- Pathophysiology in Tetralogy of Fallot / Gabriele Egidy Assenza and Michael J. Landzberg -- Tetralogy of Fallot: Late Outcome / Jochen Weil -- Tetralogy of Fallot: the Failing Right Ventricle / Folkert J. Meijboom and Barbara Mulder -- Imaging Evaluation / Claudio Bussadori -- Timing for RVOT Management / Harald Kaemmerer, Andreas Eicken and John Hess -- Percutaneous Pulmonary Valve / Mark S. Turner, Mario Carminati and Philipp Bonhoeffer -- Other Transcatheter Procedures / Massimo Chessa and Gianfranco Butera -- Surgical Pulmonary Valve Implantation / Alessandro Giamberti, Giuseppe Pomè and Alessandro Frigiola -- Other Surgical Procedures / Alessandro Giamberti -- Late Arrhythmias: Current Approaches / Sara Foresti, Maria Cristina Tavera, Pierpaolo Lupo and Riccardo Cappato -- Perioperative Right Ventricular Management / Marco Ranucci.
  • 2015 Springer
    Norbert F. Voelkel, Dietmar Schranz, editors.
    The Right Ventricle in Health and Disease provides a comprehensive and up-to-date database and collection of the available information which describes the structure and function of the normal right ventricle. The right ventricular performance and function reserve has now finally moved to the center of the stage as clinicians recognize that the drugs presently used to treat patients with severe pulmonary hypertension do not necessarily improve the performance of the right ventricle and because the survival depends on the right ventricular function that treatment strategies need to be developed to primarily protect the right ventricle from failing. In-depth chapters discuss right heart function and failure in patients with congenital heart diseases, review modern imaging techniques used to describe right ventricular form and function in patients with right heart failure (including cardiac MRI and PET scanning), describe ventricular interdependence: the left ventricle in pulmonary hypertension and discuss the concept of the sick lung circulation and its contribution to right heart failure. Treatment strategies of chronic right heart failure including drugs and mechanical devices are also discussed.
  • 2015 Cambridge
    Joseph J. Fins.
    Decisions -- The injury -- Coming to terms with brain injury -- The origins of the vegetative state -- A shift since Quinlan -- Maggie's wishes -- Something happened in Arkansas -- From PVS to MCS -- Leaving the hospital -- Heather's story -- Neuroimaging and neuroscience in the public mind -- Contractures and contradictions : medical necessity and the injured brain -- Minds, monuments, and moments -- Heads and hearts, toil and tears -- What do families want? -- Deep brain stimulation in MCS -- Mending our brains, minding our ethics -- It's still freedom -- Maggie's in town -- When consciousness becomes prosthetic -- The rights of mind -- A call for advocacy.
  • 2012
    Johanna Roberta Schaub.
    Primary cilia have critical sensory and signaling roles in development and disease. These functions rely on the proper localization of structural and signaling proteins to the cilium. Ciliary trafficking is the movement of proteins to, within, and from the cilium, processes that are regulated by several classes of proteins, for example: endo- and exocytic machinery, diffusion barriers, and motor proteins. To understand how ciliary trafficking is regulated we used gene expression data from multi-ciliated cells to identify two proteins involved in ciliary trafficking: the Rilp-like proteins Rilpl1 and Rilpl2. We took three approaches to characterizing these proteins: 1) examining localization of Rilpl1 and Rilpl2 in mammalian cells, 2) determining the phenotype of cells depleted of Rilpl1 and/or Rilpl2, and 3) identifying interaction partners. We found that Rilpl2 is up-regulated during ciliogenesis and localizes to the centrosome and primary cilium. Rilpl1 also localizes to the primary cilium and is a distal mother centriole protein with cell-cycle dependent localization. Additionally, Rilp-like proteins form dynamic tubules from the base of the cilium, which are microtubule dependent and induced by disruption of the actin network. Depletion of Rilpl1 and/or Rilpl2 from ciliated cells leads to an accumulation of signaling proteins in the ciliary membrane and disrupts epithelial cell organization in three-dimensional culture. We also determined that both Rilpl1 and Rilpl2 interact with Rab36. Taken together, our data suggest that Rilp-like proteins control ciliary protein content through the regulation of ciliary protein removal.
  • 2006 ScienceDirect
    edited by Thomas Barrett, Paul-Pierre Pastoret, and William P. Taylor.
  • 2006 Springer
    edited by Alison Jolly ... [et al.].
    The distribution and biogeography of the ringtailed lemur (Lemur catta) in Madagascar / Steven M. Goodman, Soava V. Rakotoarisoa and Lucienne Wilmé -- A preliminary estimate of Lemur catta population density using satellite imagery / Robert W. Sussman ... [et al.] -- Berenty Reserve : a research site in southern Madagascar / Alison Jolly ... [et al.] -- Beza Mahafaly Special Reserve : a research site in southwestern Madagascar / Robert W. Sussman and Joelisoa Ratsirarson -- Plant species fed on by Lemur catta in gallery forests of the southern domain of Madagascar / Bruno Simmen ... [et al.] -- Tamarind recruitment and long-term stability in the gallery forest at Berenty, Madagascar / Kathryn Blumenfeld-Jones ... [et al.] -- Home ranges of ringtailed lemur troops and the density of large trees at Berenty Reserve, Madagascar / Naoki Koyama ... [et al.] -- The influence of tamarind tree quality and quantity on Lemur catta behavior / Anne S. Mertl-Millhollen ... [et al.] -- Feeding competition between introduced Eulemur fulvus and native Lemur catta during the birth season at Berenty Reserve, southern Madagascar / Susan Pinkus, James N.M. Smith and Alison Jolly -- Tradition and novelty : Lemur catta feeding strategy on introduced tree species at Berenty Reserve / Takayo Soma -- Diet quality and taste perception of plant secondary metabolites by Lemur catta / B. Simmen ... [et al.] -- Territory as bet-hedging : Lemur catta in a rich forest and an erratic climate / Alison Jolly ... [et al.] -- Resource defense in Lemur catta : the importance of group size / R. Ethan Pride ... [et al.] -- Social changes in a wild population of ringtailed lemurs (Lemur catta) at Berenty, Madagascar / Shinichiro Ichino and Naoki Koyama -- Obsession with agonistic power / Michael. E. Pereira -- Male and female ringtailed lemurs' energetic strategy does not explain female dominance / Hantanirina Rasamimanana ... [et al.] -- Male sociality and integration during the dispersal process in Lemur catta : a case study / Lisa Gould -- Patterns of health, disease, and behavior among wild ringtailed lemurs, Lemur catta: effects of habitat and sex / Michelle L. Sauther ... [et al.] -- Bald lemur syndrome and the miracle tree : alopecia associated with Leucaena leucocephala at Berenty Reserve, Madagascar / Graham C. Crawford ... [et al.] -- Temporal change in tooth size among ringtailed lemurs (Lemur catta) at the Beza Mahafaly Special Reserve, Madagascar : effects of an environmental fluctuation / Frank P. Cuozzo and Michelle L. Sauther.
  • 2005 Springer
    [edited by] Pierre Savagner.
  • Jonathan Hughes.
    Pt. 1. Alchemy and the occult in English cultural and political life. Introduction : alchemy and the occult in England ; The origins of English alchemy and sources for the study of alchemy in fourteenth-century England -- Pt. 2. The Astrology of the earth : the intellectual impact of alchemy in fourteenth-century England. Alchemy and science and philosophy ; Alchemy and the Church ; The Cultural impact of alchemy -- Pt. 3. The Political significance of alchemy. The accession of Edward III ; Alchemical themes in the kingship of Edward III ; Richard II the magus and boy king ; Richard II and the occult ; Conclusion : the Lancastrian reaction.
  • 2013 Springer
    Lawrence D. Longo ; foreword by John R.G. Challis.
    During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal breathing movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance. Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants.
  • 2013
    Lisa I. Iezzoni, editor.
    Reasons for risk adjustment / Lisa I. Iezzoni -- Getting started and defining terms / Lisa I. Iezzoni -- Range of risk factors / Lisa I. Iezzoni -- Windows of observation / Amy K. Rosen and Ann M. Borzecki -- Coded data from administrative sources / Lisa I. Iezzoni -- Clinical data from medical records and health information technologies / Lisa I. Iezzoni -- Data from patient surveys / Lisa I. Iezzoni and Karen Donelan -- Conceptual and practical issues in developing risk adjustment methods / Lisa I. Iezzoni -- Validity and reliability of risk adjustment methods / Lisa I. Iezzoni -- Empirically evaluating risk adjustment models / Michael Shwartz and Arlene S. Ash -- Estimating the effect of an intervention from observational data / Michael Shwartz and Arlene S. Ash -- Comparing outcomes across providers / Arlene S. Ash ... [et al.] -- Risk adjustment in pediatric populations / Karen Kuhlthau, Jeanne Van Cleave, and Timothy G. Ferris -- Risk adjustment for mental health care / Anthony P. Weiss and Mark A. Blais -- Risk adjustment and persons with disabilities / Lisa I. Iezzoni -- Risk adjustment for long-term care / Dan Berlowitz and Orna Intrator -- The role of risk adjustment in managing health care organizations / Jennifer Daley -- Final observations / Lisa I. Iezzoni.
  • 2007 Springer
    edited by Manfred S. Green, Jonathan Zenilman, Dani Cohen, Itay Wiser, and Ran D. Balicer.
  • 2009
    Status: Not Checked OutLane Catalog Record
  • 2009
    Status: Not Checked OutLane Catalog Record
  • 2011
    "Vibrio parahaemolyticus are common causes of diarrhoeal disease worldwide. These marine micro-organisms, native in estuarine waters globally, concentrate in the gut of filter-feeding molluscan shellfish, such as oysters, clams and mussels. Raw and undercooked seafood, including finfish, represent the principal vehicle of transmission to humans. This volume considers the applicability of an assessment of the public health impact of raw oyster consumption, developed in one country, to assess the public health risk associated with the consumption of raw oysters harvested in other countries where different growing and harvesting scenarios might exist. The approach is also applied to bloody clams and finfish to establish if such a risk assessment can also be adapted to other types of shellfish and finfish. This work is therefore divided in three parts focusing on (i) risk assessment of Vibrio parahaemolyticus in raw oysters, (ii) risk assessment of Vibrio parahaemolyticus in bloody clam and (iii) risk assessment of Vibrio parahaemolyticus in finfish. As well as providing insights on the risks associated with consumption of these commodities, the work also addresses how to make maximum use of existing and/or limited resources"--P. [4] of cover.
  • 2009
    World Health Organization, Food and Agriculture Organization of the United Nations.
    Status: Not Checked OutLane Catalog Record
  • 2011 ClinicalKey
    Phil Haeck, Mark Gorney.
    "Risk, Liability and Malpractice: What Every Plastic Surgeon Need To Know" is your indispensable guide to maintaining a reputable, safe, successful plastic surgery practice. Authors Phil Haeck, MD and Mark Gorney, MD, two of the best-known and most trusted authorities on this subject, discuss every issue you need to consider, from which procedures carry the highest risk through claims arising from Medi-Spas and unique aspects of providing aesthetic surgery for male patients. Written in a concise and easy-to-read style, this is the book you need to make wise clinical and practice decisions, manage your patients' expectations, avoid complications, and deliver satisfying results. Effectively navigate your toughest legal issues! Must-read chapters include "The Most Risky Procedures in Plastic Surgery," "Claims Arising From Medi-Spas," and "The Unique Aspects of The Male Patient and Aesthetic Surgery." Get advice you can trust! Phil Haeck, MD has been writing Plastic Surgery News's "On Legal Grounds" column for more than five years and is the 2011/2012 president of ASPS. Mark Gorney, MD, a former ASPS president, is a founding member of The Doctors Company, now the country's largest malpractice insurance carrier, and has taught the basics in risk management to thousands of his colleagues. Read it quickly and put it to work in your practice! A concise, practical approach with minimal legal jargon presents the guidance you need in a way that is easy to understand and apply.
  • 2016 Springer
    Walter Merkle, editor.
    Why do we wrong, although we want to do right?- Current view of German Authorities -- Human behavior in process management -- Successful strategies to detect and avoid failures -- Risk management in aviation -- Risk management in medicine ? principles -- Risk management in the US medicine -- Systemic coaching of staff as risk management tool -- CIRS (Critical Incident Reporting System) -- OTAS (Observational Teamwork Assessment for Surgery) -- FMEA (Failure Mode and Effects Analysis) -- TTO (Team Time Out) -- Peer-Review.- CRM (Crew Ressource Management).- Law aspects-Germany -- Law aspects -- Europe -- Law Aspects -- USA -- Insurances problems -- Implementation of risk management in hospitals -- Economic aspects of risk management -- ISO in medical risk management.
  • 2008 Springer
    Marvin F. Kraushar, editor.
    Part 1 : General considerations -- Basic medical malpractice terminology -- The defense attorney -- The plaintiff's attorney -- The trial judge -- The medical expert -- Sequence of events in a medical malpractice lawsuit -- Informed consent -- The five most effective risk prevention strategies -- Revelation of adverse events and the conundrum of an apology -- Part 2 : Risk management in the ophthalmic subspecialties and related fields -- Anesthesia -- Cataract surgery -- Cornea : external disease and contact lenses -- Drugs -- Emergencies -- Glaucoma -- Neuroophthalmology -- Oncology -- Ophthalmic plastic surgery -- Pediatric ophthalmology -- Refractive corneal surgery -- Retina and vitreous -- Uveitis -- Part 3 : Personal and business considerations -- Physician and defendant : living and coping with a double life -- Medical malpractice insurance : selection of companies and policies.
  • 2006
    edited by Thomas Schlich and Ulrich Tröhler.
    Status: Not Checked OutLane Catalog Record
    Risk and medical innovation : a historical perspective / Thomas Schlich -- To assess and to improve : practitioners' approaches to doubts linked with medical innovations 1720-1920 / Ulrich Tröhler -- Anaesthesia and the evaluation of surgical risk in mid-nineteenth century Britain / Ian Burney -- Redemption, danger and risk : the history of anti-bacterial chemotherapy and the transformation of tuberculin / Christoph Gradmann -- "As safe as milk or sugar water" : perceptions of the risks and benefits of the BCG vaccine in the 1920s and 1930s in France and Germany / Christian Bonah -- From danger to risk : the perception and regulation of X-rays in Switzerland, 1896-1970 / Monika Dommann -- The population as patient : Alice Stewart and the controversy over low-level radiation in the 1950s / Sarah Dry -- To treat or not to treat : drug research and the changing nature of essential hypertension / Carsten Timmermann -- Hormones at risk : cancer and the medical uses of industrially-produced sex steroids in Germany, 1930-1960 / Jean-Paul Gaudillière -- Risk assessment and medical authority in operative fracture care in the 1960 and 1970s / Thomas Schlich -- Assessing the risk and safety of the pill : maternal mortality and the pill / Lara Marks -- Addressing uncertainties : the conceptualization of brain death in Switzerland 1960-2000 / Silke Bellanger and Aline Steinbrecher -- Risk on trial : the interaction of innovation and risk in cancer clinical trials / Peter Keating and Alberto Cambrosio -- BioRisk : interleukin-2 from laboratory to market in the United States and Germany / Arthur Daemmrich -- The redemption of Thalidomide : standardizing the risk of birth defects / Stefan Timmermans and Valerie Leiter.
  • 2009 Springer
    rédacteurs: M. Fieschi ... [et al.].
  • 2010
    edited by Glenn Frankel ; designed by Kelly Dubeau.
    Status: Not Checked OutLane Catalog Record
    The Heart of the matter : for one family with a five-year-old with chronic disease, normal life is the greatest gift / by Kathryn Roethel -- Bus to nowhere : for Silicon Valley's homeless population, Hotel 22 is an endless ride / by Miranda Simon -- The Good death : "No One Dies Alone" is a volunteer program and a promise / by Ryan Mac -- The Clean room : why did so many IBM employees come down with cancer after working in Silicon Valley? / by Lily Bixler -- Shelter from the storm : in a time of budgetary crisis, abused women still need help / by Kristen Barta -- Punched in the gut : can a family ever recover from an eating disorder? / by Erin Beresini.
  • 2008 Springer Protocols
    edited by Henrik Nielsen.
    The transcriptional landscape -- Working with RNA -- Synthesis of RNA by in vitro transcription -- Efficient poly(A)+ RNA selection using LNA oligo(T) capture -- Genome browsers -- Web-based tools for studying RNA structure and function -- Northern blotting analysis -- Rapid amplification of cDNA ends (RACE) -- Fractionation of mRNA based on the length of the poly(A) tail -- Analysis of mutations that influence pre-mRNA splicing -- S1 nuclease analysis of alternatively spliced mRNA -- Promises and challenges in developing RNAi as a research tool and therapy -- Inhibition of gene function in mammalian cells using short-hairpin RNA (shRNA) -- Validation of RNAi by real time PCR -- Profiling RNA polymerase II using the fast chromatin immunoprecipitation method -- The post-transcriptional operon -- RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray (chip) profiling -- Isolation of RNP granules -- Electrophoretic mobility shift assay for characterizing RNA-protein interaction -- Polysome analysis and RNA purification from sucrose gradients -- Prediction of targets for microRNAs -- Outsourcing of experimental work.
  • 2012 Springer Protocols
    edited by Hailing Jin, Walter Gassmann.
    SuperSAGE : powerful serial analysis of gene expression / Hideo Matsumura [and others] -- Northern blot analysis for expression profiling of mRNAs and small RNAs / Ankur R. Bhardwaj [and others] -- Construction of RNA-seq libraries from large and microscopic tissues for the illumina sequencing platform / Hagop S. Atamian and Isgouhi Kaloshian -- Strand-specific RNA-seq applied to malaria samples / Nadia Ponts, Duk-Won D. Chung, and Karine G. Le Roch -- RNA in situ hybridization in Arabidopsis / Miin-Feng Wu and Doris Wagner -- Laser microdissection of cells and isolation of high-quality RNA after cryosectioning / Marta Barcala, Carmen Fenoll, and Carolina Escobar -- Detection and quantification of alternative splicing variants using RNA-seq / Douglas W. Bryant Jr, Henry D. Priest, and Todd C. Mockler -- Separating and analyzing sulfur-containing RNAs with Organomercury Gels / Elisa Biondi and Donald H. Burke -- RNAse mapping and quantitation of RNA isoforms / Lakshminarayan K. Venkatesh, Olufemi Fasina, and David J. Pintel -- Detection and quantification of viral and satellite RNAs in plant hosts / Sun-Jung Kwon, Jang-Kyun Seo, and A.L.N. Rao -- In situ detection of mature miRNAs in plants using LNA-modified DNA probes / Xiaozhen Yao, Hai Huang, and Lin Xu -- Small RNA isolation and library construction for expression profiling of small RNAs from neurospora and fusarium using illumina high-throughput deep sequencing / Gyungsoon Park and Katherine A. Borkovich -- Isolation and profiling of protein-associated small RNAs / Hongwei Zhao [and others] -- New virus discovery by deep sequencing of small RNAs / Kashmir Singh, Ravneet Kaur, and Wenping Qiu -- Global assembly of expressed sequence tags / Foo Cheung -- Computational analysis of RNA-seq / Scott A. Givan, Christopher A. Bottoms, and William G. Spollen -- Identification of microRNAs and natural antisense transcript-originated endogenous siRNAs from small-RNA deep sequencing data / Weixiong Zhang [and others].
  • 2013 Springer
    edited by Jane Wu.
    Coupling Between Transcription and Alternative Splicing / Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt -- Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray / Marieta Gencheva ... [et al.] -- Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing / Lulzim Shkreta ... [et al.] -- Alternative Splicing of Tumor Suppressors and Oncogenes / Claudia Ghigna, Silvano Riva, Giuseppe Biamonti -- MicroRNAs in Cancer / Jianzhong Jeff Xi -- The Perinucleolar Compartment: RNA Metabolism and Cancer / John T. Norton, Sui Huang -- Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer / Christian Kroun Damgaard, Jens Lykke-Andersen -- Alternative Pre-mRNA Splicing, Cell Death, and Cancer / Kong Ruirui ... [et al.] -- Oligonucleotide Therapeutics in Cancer / Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani -- Clinical Perspective on Chemo-Resistance and the Role of RNA Processing / Nancy L. Krett, Shuo Ma, Steven T. Rosen.
    Also available: Print – 2013
  • 2011 Springer Protocols
    edited by Ruslan Aphasizhev.
    Three-dimensional reconstruction of trypanosoma brucei editosomes using single-particle electron microscopy / H.U. Goringer ... [et al.] -- Icoda: RNAi-based inducible knock-in system in trypanosoma brucei / G.E. Ringpis, R.H. Lathrop and R. Aphasizhev -- Perturbing a-to-i RNA editing using genetics and homologous recombination / C.J. Staber ... [et al.] -- Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis / H. Sun ... [et al.] -- Biochemical identification of A-to-I RNA editing sites by the inosine chemical erasing (ice) method / M. Sakurai and T. Suzuki -- Identifying mRNA editing deaminase targets by RNA-seq / B.R. Rosenberg, S. Dewell and F.N. Papavasiliou -- Mouse and other rodent models of C to U RNA editing / V. Blanc and N.O. Davidson -- In vivo analysis of RNA editing in plastids / S. Ruf and R. Bock -- Identifying specific trans-factors of RNA editing in plant mitochondria by multiplex single base extension typing / M. Takenaka -- Complementation of mutants in plant mitochondrial RNA editing by protoplast transfection / M. Takenaka and A. Zehrmann -- A high-throughput assay for DNA deaminases / M. Wang, C. Rada and M.S. Neuberger -- Biochemical fractionation and purification of high-molecular-mass apobec3g complexes / Y.L. Chiu -- Analysis of tRNA editing in native and synthetic substrates / J.L. Spears, K.W. Gaston and J.D. Alfonzo -- Post-transcriptional modification of RNAs by artificial box h/aca and box c/d rnps / C. Huang, J. Karijolich and Y.T. Yu -- Functional analysis of noncoding RNAs in trypanosomes: RNA walk, a novel approach to study RNA-RNA interactions between small RNA and its target / C. Wachtel and S. Michaeli -- A post-labeling approach for the characterization and quantification of RNA modifications based on site-directed cleavage by dnazymes / M. Meusburger, M. Hengesbach and M. Helm.
  • 2015 Springer Protocols
    edited by Ernesto Picardi.
    Free energy minimization to predict RNA secondary structures and computational RNA design / Alexander Churkin, Lina Weinbrand, and Danny Barash -- RNA secondary structure prediction from multi-aligned sequences / Michiaki Hamada -- Simple protocol for the inference of RNA global pairwise alignments / Eugenio Mattei, Manuela Helmer-Citterich, and Fabrizio Ferrè -- De novo secondary structure motif discovery using RNA profile / Federico Zambelli and Giulio Pavesi -- Drawing and editing the secondary structure(s) of RNA / Yann Ponty and Fabrice Leclerc -- Modeling and predicting RNA three-dimensional structures / Jérôme Waldispühl and Vladimir Reinharz -- Fast prediction of RNA-RNA interaction using heuristic algorithm / Soheila Montaseri -- Quality control of RNA-Seq experiments / Xing Li ... [and 3 others] -- Accurate mapping of RNA-Seq data / Kin Fai Au -- Quantifying entire transcriptomes by aligned RNA-Seq data / Raffaele A. Calogero and Francesca Zolezzi -- Transcriptome assembly and alternative splicing analysis / Paola Bonizzoni ... [and 5 others] -- Detection of post-transcriptional RNA editing events / Ernesto Picardi ... [and 3 others] -- Prediction of miRNA targets / Anastasis Oulas ... [and 6 others] -- Using deep sequencing data for identification of editing sites in mature miRNAs / Shahar Alon and Eli Eisenberg -- NGS-trex : an automatic analysis workflow for RNA-seq data / Ilenia Boria ... [and 3 others] -- e-DNA meta-barcoding : from NGS raw data to taxonomic profiling / Fosso Bruno, Marzano Marinella, and Monica Santamaria -- Deciphering metatranscriptomic data / Evguenia Kopylova ... [and 6 others] -- RIP-seq data analysis to determine RNA-protein associations / Federico Zambelli and Giulio Pavesi -- ViennaRNA eeb services / Andreas R. Gruber, Stephan H. Bernhart, and Ronny Lorenz -- Exploring the RNA editing potential of RNA-Seq data by ExpEdit / Mattia D'Antonio ... [and 4 others] -- Guideline for the annotation of UTR regulatory elements in the UTRsite collection / Matteo Giulietti ... [and 3 others] -- Rfam : annotating families of non-coding RNA sequences / Jennifer Daub ... [and 3 others] -- ASPicDB : a database web tool for alternative splicing analysis / Mattia D'Antonio ... [and 5 others] -- Analysis of alternative splicing events in custom gene datasets by AStalavista / Sylvain Foissac and Michael Sammeth -- Computational design of artificial RNA molecules for gene regulation / Alessandro Laganà ... [and 6 others].
  • 2012 Springer
    Neocles Leontis, Eric Westhof, editors.
    Introduction / Michael Levitt -- Modeling RNA Molecules / Neocles Leontis and Eric Westhof -- Methods for Predicting RNA Secondary Structure / Kornelia Aigner, Fabian Dre€en and Gerhard Steger -- Why Can't We Predict RNA Structure At Atomic Resolution? / Parin Sripakdeevong, Kyle Beauchamp and Rhiju Das -- Template-Based and Template-Free Modeling of RNA 3D Structure: Inspirations from Protein Structure Modeling / Kristian Rother, Magdalena Rother, Michał Boniecki, Tomasz Puton and Konrad Tomala, et al. -- The RNA Folding Problems: Different Levels of sRNA Structure Prediction / Fredrick Sijenyi, Pirro Saro, Zheng Ouyang, Kelly Damm-Ganamet and Marcus Wood, et al. -- Computational Prediction and Modeling Aid in the Discovery of a Conformational Switch Controlling Replication and Translation in a Plus-Strand RNA Virus / Wojciech K. Kasprzak and Bruce A. Shapiro -- Methods for Building and Refining 3D Models of RNA / Samuel C. Flores, Magdalena Jonikas, Christopher Bruns, Joy P. Ku and Jeanette Schmidt, et al. -- Multiscale Modeling of RNA Structure and Dynamics / Feng Ding and Nikolay V. Dokholyan -- Statistical Mechanical Modeling of RNA Folding: From Free Energy Landscape to Tertiary Structural Prediction / Song Cao and Shi-Jie Chen -- Simulating Dynamics in RNA-Protein Complexes / John Eargle and Zaida Luthey-Schulten -- Quantum Chemical Studies of Recurrent Interactions in RNA 3D Motifs / Jiří Šponer, Judit E. Šponer and Neocles B. Leontis -- Nonredundant 3D Structure Datasets for RNA Knowledge Extraction and Benchmarking / Neocles B. Leontis and Craig L. Zirbel -- Ions in Molecular Dynamics Simulations of RNA Systems / Pascal Auffinger -- Modeling RNA Folding Pathways and Intermediates Using Time-Resolved Hydroxyl Radical Footprinting Data / Joshua S. Martin, Paul Mitiguy and Alain Laederach -- A Top-Down Approach to Determining Global RNA Structures in Solution Using NMR and Small-Angle X-ray Scattering Measurements / Yun-Xing Wang, Jinbu Wang and Xiaobing Zuo -- RNA Structure Determination by Structural Probing and Mass Spectrometry: MS3D / A. E. Hawkins and D. Fabris.
  • 2011 Springer Protocols
    edited by Jeffrey E. Gerst.
    Single molecule imaging of RNA in situ / Mona Batish, Arjun Raj, and Sanjay Tyagi -- FISH and immunofluorescence staining in Chlamydomonas / James Uniacke, Daniel Colón-Ramos, and William Zerges -- High resolution fluorescent in situ hybridization in Drosophila / Eric Lécuyer -- Localization and anchorage of maternal mRNAs to cortical structures of ascidian eggs and embryos using high resolution in situ hybridization / Alexandre Paix, Janet Chenevert, and Christian Sardet -- Visualization of mRNA localization in Xenopus oocytes / James A. Gagnon and Kimberly L. Mowry -- Visualization of mRNA expression in the zebrafish embryo / Yossy Machluf and Gil Levkowitz -- High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo / Sharon A. Swanger, Gary J. Bassell, and Christina Gross -- Localization of mRNA in vertebrate axonal compartments by in situ hybridization / José Roberto Sotelo-Silveira ... [et al.] -- Tiny molecular beacons for in vivo mRNA detection / Diana P. Bratu, Irina E. Catrina, and Salvatore A.E. Marras -- Delivery of molecular beacons for live-cell imaging and analysis of RNA / Antony K. Chen ... [et al.] -- Genetically-encoded fluorescent probes for imaging endogenous mRNA in living cells / Takeaki Ozawa and Yoshio Umezawa -- Visualization of induced RNA in single bacterial cells / Azra Borogovac and Natalia E. Broude -- Visualizing mRNAs in fixed and living yeast cells / Franck Gallardo and Pascal Chartrand -- In vivo visualization of RNA using the U1A-based tagged RNA system / Sunglan Chung and Peter A. Takizawa -- Visualizing endogenous mRNAs in living yeast using m-TAG, a PCR-based RNA aptamer integration method, and fluorescence microscopy / Liora Haim-Vilmovsky and Jeffrey E. Gerst -- Imaging mRNAs in living mammalian cells / Sharon Yunger and Yaron Shav-Tal -- Using the mRNA-MS2/MS2CP-FP system to study mRNA transport during Drosophila oogenesis / Katsiarina Belaya and Daniel St Johnston -- Genome-wide analysis of RNA extracted from isolated mitochondria / Erez Eliyahu, Daniel Melamed and Yoav Arava -- Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation / Sujatha Jagannathan, Christine Nwosu and Christopher V. Nicchitta -- Isolation of mRNAs encoding peroxisomal proteins from yeast using a combined cell fractionation and affinity purification procedure / Gadi Zipor, Cecile Brocard and Jeffrey E. Gerst -- Profiling axonal mRNA transport / Dianna E. Willis and Jeffery L. Twiss -- RNA purification from tumor cell protrusions using porous polycarbonate filters / Jay Shankar and Ivan R. Nabi -- RNA-binding protein immunopurification-microarray (RIP-chip) analysis to profile localized RNAs / Alessia Galgano and André P. Gerber -- RaPID : an aptamer-based mRNA affinity purification technique for the identification of RNA and protein factors present in ribonucleoprotein complexes / Boris Slobodin and Jeffrey E. Gerst -- RIP : an mRNA localization technique / Sabarinath Jayaseelan ... [et al.] -- The dual use of RNA aptamer sequences for affinity purification and localization studies of RNAs and RNA-protein complexes / Scott C. Walker ... [et al.] -- Identifying and searching for conserved RNA localisation signals / Russell S. Hamilton and Ilan Davis -- Computational prediction of RNA structural motifs involved in post-transcriptional regulatory processes / Michal Rabani, Michael Kertesz, and Eran Segal.
  • 2008 Springer
    H. Ulrich Göringer (ed.).
    Editing reactions from the perspective of RNA structure / Matthias Homann -- Editing of tRNA for structure and function / Juan D. Alfonzo -- RNA editing by adenosine deaminases that act on RNA (ADARs) / Michael F. Jantsch and Marie Öhman -- Insertion/deletion editing in Physarum polycephalum / Jonatha M. Gott and Amy C. Rhee -- RNA editing in plant mitochondria / Mizuki Takenaka ... [et al.] -- RNA editing in chloroplasts / Masahiro Sugiura -- Working together : the RNA editing machinery in Trypanosoma brucei / Jason Carnes and Kenneth Stuart -- RNA editing accessory factors : the example of mHel61p / H. Ulrich Göringer ... [et al.] -- The function of RNA editing in trypanosomes / Torsten Ochsenreiter and Stephen Hajduk -- Evolutionary aspects of RNA editing / Dave Speijer.
  • 2007 ScienceDirect
    edited by Jonatha M. Gott.
    Also available: Print – 2007
  • 2011 Springer
    edited by Torben Heick Jensen.
    "The diversity of RNAs inside living cells is amazing. We have known of the more "classic" RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of the book to introduce this fascinating protein complex and to give a timely and rich account of its many functions"--Provided by publisher.
    Also available: Print – 2011
  • 2014 Springer Protocols
    edited by Christina Waldsich.
    Predicting RNA Structure: Advances and Limitations -- Cis-Acting 5' Hammerhead Optimization for In Vitro Transcription of Highly Structured RNAs -- RNA Structural Analysis by Enzymatic Digestion -- A Mutate-and-Map Protocol for Inferring Base Pairs in Structured RNA -- Mapping RNA Structure In Vitro Using Nucleobase-Specific Probes -- Massively Parallel RNA Chemical Mapping with a Reduced Bias MAP-Seq Protocol -- Probing RNA Folding by Hydroxyl Radical Footprinting -- Monitoring Global Structural Changes and Specific Metal Binding Sites in RNA by In-Line Probing and Tb(III) Cleavage -- Chemical Probing of RNA in Living Cells -- A Chemogenetic Approach to Study the Structural Basis of Protein-Facilitated RNA Folding -- Applying UV Crosslinking to Study RNA-Protein Interactions in Multicomponent Ribonucleoprotein Complexes -- The Kinetics of Ribozyme Cleavage: A Tool to Analyze RNA Folding as a Function of Catalysis -- RNA Catalytic Activity as a Probe of Chaperone-Mediated RNA Folding -- Evaluation of RNA Chaperone Activity In Vivo and In Vitro Using Misfolded Group I Ribozymes -- RNA Conformational Changes Analyzed by Comparative Gel Electrophoresis -- Detecting RNA Tertiary Folding by Sedimentation Velocity Analytical Ultracentrifugation -- RNA Folding Dynamics Using Laser Assisted Single-Molecule Refolding -- RNA Refolding Studied by Light-Coupled NMR Spectroscopy -- Exploring RNA Oligomerization and Ligand Binding by Fluorescence Correlation Spectroscopy and Small Angle X-Ray Scattering.
  • 2012 ScienceDirect
    edited by Eckhard Jankowsky.
    This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes.
  • 2016 Springer Protocols
    edited by Zdravka Medarova.
    Imaging functional nucleic acid delivery to skin / Roger L. Kaspar ... [et al.] -- In vivo magnetic resonance imaging of small interfering RNA nanodelivery to pancreatic islets / Ping Wang and Anna Moore -- Magnetic resonance spectroscopy of siRNA-based cancer therapy / Marie-France Penet ... [et al.] -- Targeted delivery with imaging assessment of siRNA expressing nanocassettes into cancer / Wei Chen and Lily Yang -- Analyses of tumor burden in vivo and metastasis ex vivo using luciferase-expressing cancer cells in an orthotopic mouse model of neuroblastoma / Frances L. Byrne, Joshua A. McCarroll, and Maria Kavallaris -- Indium-labeling of siRNA for small animal SPECT imaging / Steven Jones and Olivia Merkel -- Imaging of electrotransferred siRNA / Muriel Golzio and Justin Teissié -- Whole-body scanning PCR, a tool for the visualization of the in vivo biodistribution pattern of endogenous and exogenous oligonucleotides in rodents / Julien A. Boos and Iwan Beuvink -- siRNA nanoparticles for ultra-long gene silencing in vivo / Seung Koo Lee and Ching-Hsuan Tung -- Sensing miRNA : signal amplification by cognate RISC for intracellular detection of miRNA in live cells / Amol Kavishwar and Zdravka Medarova -- Molecular beacon-based microRNA imaging during neurogenesis / Jonghwan Lee and Soonhag Kim -- Hypoxia-responsive copolymer for siRNA delivery / Federico Perche ... [et al.] -- Controlling RNA expression in cancer using iron oxide nanoparticles detectable by MRI and in vivo optical imaging / Zdravka Medarova, Mustafa Balcioglu, and Mehmet V. Yigit -- Microvesicles : isolation, characterization for in vitro and in vivo procedures / Karmele Valencia and Fernando Lecanda -- Positive bioluminescence imaging of microRNA expression in small animal models using an engineered genetic-switch expression system, RILES / Patrick Baril and Chantal Pichon -- MicroRNA imaging in combination with diagnostic ultrasound and bubble liposomes for microRNA delivery / Yoko Endo-Takahashi ... [et al.].
  • 2011 Springer
    edited by Lesley J. Collins.
    The RNA infrastructure : an introduction to ncRNA networks / Lesley J. Collins -- RNA interactions / Manja Marz and Peter F. Stadler -- Plant RNA silencing in viral defence / Vitantonio Pantaleo -- Micrornas as post-transcriptional machines and their interplay with cellular networks / Sarath Chandra Janga and Swathi Vallabhaneni -- Spatiotemporal aspects of microRNA-mediated gene regulation / Joris Pothof and Dik C. van Gent -- Spliceosomal RNA infrastructure : the network of splicing components and their regulation by miRNAs / Lesley J. Collins -- Construction, structure, and dynamics of post-transcriptional regulatory network directed by RNA binding proteins / Sarath Chandra Janga and Nitish Mittal -- Safe keeping the message : mRNP complexes tweaking after transcription / Said Hafidh, Věra Čapková, and David Honys -- Unexpected functions of tRNA and tRNA processing enzymes / Rebecca L. Hurto -- Programmed DNA elimination in tetrahymena : a small RNA mediated genome surveillance mechanism / Kensuke Kataoka and Kazufumi Mochizuki -- Long noncoding RNA and epigenomics / Chandrasekhar Kanduri -- Promoter associated long noncoding RNAs repress transcription through a RNA binding protein TLS / Riki Kurokawa -- RNA networks in prokaryotes I :CRISPRs and riboswitches / Patrick J. Biggs and Lesley J. Collins -- RNA networks in prokaryotes II : tRNA processing and small RNAs / Lesley J. Collins and Patrick J. Biggs -- Localization of the bacterial RNA infrastructure / Kenneth C. Keiler -- Small RNA discovery and characterisation in eukaryotes using high throughput approaches / Helio Pais ... [et al.] -- How old are RNA networks? / Toni Daly, X. Sylvia Chen, and David Penny.
  • 2008 Springer
    Patrick J. Paddison, Peter K. Vogt, editors.
    RNA interference in mammalian cell systems / Patrick J. Paddison -- RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard -- Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi ... [et al.] -- Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz -- The mechanism of RNase III action: how dicer dices / Xinhua Ji -- MicroRNA metabolism in plants / Xuemei Chen -- Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron -- RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire -- A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin -- RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris -- RNA silencing in mammalian oocytes and early embryos / Petr Svoboda -- Identifying human microRNAs / Isaac Bentwich.
    Also available: Print – 2008
  • 2005 ScienceDirect
    edited by David R. Engelke, John J. Rossi.
    Also available: Print – 2005
  • 2015 Springer Protocols
    edited by Mouldy Sioud.
    RNA interference : mechanisms, technical challenges, and therapeutic opportunities / Mouldy Sioud -- Nanostructured RNAs for RNA interference / Yuko Nakashima [and others] -- One long oligonucleotide or two short oligonucleotides based shRNA construction and expression / Xue-jun Wang and Sheng-qi Wang -- PLGA microspheres encapsulating siRNA / Giuseppe De Rosa and Giuseppina Salzano -- Magnetic nanoparticle and magnetic field assisted siRNA delivery in vitro / Olga Mykhaylyk [and others] -- Cytoplasmic delivery of siRNAs to monocytes and dendritic cells via electroporation / Mouldy Sioud -- Delivery of siRNAs to cancer cells via bacteria / Omar Ahmed, Andrea Krühn, and Hermann Lage -- Microwell array-mediated delivery of lipoplexes containing nucleic acids for enhanced therapeutic efficacy / Yun Wu, Daniel Gallego-Perez, and L. James Lee -- Modulating the tumor microenvironment with RNA interference as a cancer treatment strategy / Karin Zins [and others] -- Targeted in vivo delivery of siRNA and an endosome- releasing agent to hepatocytes / Magdolna G. Sebestyén [and others] -- Cell-internalization SELEX : method for identifying cell- internalizing RNA aptamers for delivering siRNAs to target cells / William H. Thiel [and others] -- Strategies for siRNA navigation to desired cells / Mouldy Sioud -- Use of guanidinopropyl-modified siRNAs to silence gene expression / Maximilian C.R. Buff [and others] -- Therapy of respiratory viral infections with intranasal siRNAs / Sailen Barik and Patrick Lu -- Engineering therapeutic cancer vaccines that activate antitumor immunity / Per Ole Iversen and Mouldy Sioud -- Immunosuppressive factor blockade in dendritic cells via siRNAs results in objective clinical responses / Mouldy Sioud, Anne Mobergslien, and Stein Sæbøe-Larssen -- Targeting bcr-abl transcripts with siRNAs in an imatinib- resistant chronic myeloid leukemia patient : challenges and future directions / Michael Koldehoff -- Facile method for interfering with off-target silencing mediated by the sense strand / Anne Mobergslien and Mouldy Sioud -- Overcoming the challenges of siRNA activation of innate immunity : design better therapeutic siRNAs / Mouldy Sioud -- Gene silencing in vitro and in vivo using intronic microRNAs / Jia Han Deng [and others] -- In silico identification of novel endo-siRNAs / Andrew Schuster [and others] -- Computer-assisted annotation of small RNA transcriptomes / Nicole Ortogero [and others] -- miR-CATCH : microRNA capture affinity technology / Sebastian Vencken [and others] -- Roles of MicroRNAs in cancers and development / Shigeru Takasaki -- Targeting microRNAs to withstand cancer metastasis / Valentina Profumo [and others] -- Urinary microRNAs as a new class of noninvasive biomarkers in oncology, nephrology, and cardiology / Hana Mlcochova [and others] -- Magnetic bead-based isolation of exosomes / Morten P. Oksvold, Axl Neurauter, and Ketil W. Pedersen -- Modified 2'-ribose small RNAs function as toll-like receptor-7/8 antagonists / Mouldy Sioud.
  • 2013 Springer
    Kenneth A. Howard, editor.
    The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment. Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of "RNA Interference from Biology to Therapeutics" that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a "must-read" for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the "future perspectives" section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation."RNA Interference from Biology to Therapeutics" is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.
  • 2011 Springer Protocols
    edited by Scott Q. Harper.
    Designing hairpin-based RNAi shuttles / Yu Shen -- Rapid cloning and validation of microRNA shuttle vectors : a practical guide / Ryan L. Boudreau [and others] -- Use of small noncoding RNAs to silence transcription in human cells / Kevin V. Morris -- Delivery strategies for RNAi to the nervous system / Kevin D. Foust and Brian K. Kaspar -- Cloning small RNAs / Eric J. Devor and Lingyan Huang -- Profiling the miRNome : detecting global miRNA expression levels with DNA microarrays / Peter White -- High-throughput profiling of mature microRNA by real-time PCR / Jinmai Jiang [and others] -- In situ detection of microRNAs in paraffin-embedded, formalin-fixed tissues : different methodologies and co-localization with possible targets / Gerard J. Nuovo [and others] -- Tracing of siRNAs inside cells by FRET imaging / Markus Hirsch [and others] -- Application of RIP-chip for the identification of miRNA targets / Lu Ping Tan, Anke van den Berg, and Joost L. Kluiver.
  • 2005 MyiLibrary
    edited by Krisharao Appasani ; forewords by Andrew Fire and Marshall Nirenberg.
    Chemical modifications to achieve increased stability and sensitive detection of siRNA -- RNA interference in postimplantation mouse embryos -- In ovo RNAi opens new possibilities for functional genomics in vertebrates -- Sect. 4. Gene silencing in model organisms. Practical applications of RNAi in C. elegans -- Inducible RNAi as a forward genetic tool in Trypanosoma brucei -- RNA-mediated gene silencing in fission yeast -- RNA silencing in filamentous fungi: Mucor ciccinelloides as a model organism -- RNAi and gene silencing phenomena mediated by viral suppressors in plants -- Sect. 1. Basic RNAi, siRNA, microRNAs and gene-silencing mechanisms. RNAi beginnings. Overview of the pathway in C. elegans -- Dicer in RNAi: its roles in vivo and utility in vitro -- Genes required for RNA interference -- MicroRNAs: a small contribution from worms -- miRNAs in the brain and the application of RNAi to neurons -- Sect. 2. Design, synthesis of siRNAs. Degign and synthesis of small interfering RNA (siRNA) -- Automated design and high throughput chemical synthesis of siRNA -- Rational design of siRNAs with the Sfold software -- Enzymatic production of small interfering RNAs -- Sect. 3. Vector development and in vivo, in vitro and in ovo delivery methods. Six methods of inducing RNAi in mammalian cells -- Viral delivery of shRNA -- siRNA delivery by lentiviral vectors: design and applications -- Liposomal delivery of siRNAs in mice -- Sect. 5. Drug target validation. Delivering siRNA in vivo for functional genomics and novel therapeutics -- The role of RNA interference in drug target validation: application to Hepatitis C -- RNAi in the drug discovery process -- RNA interference technology in the discovery and validation of druggable targets -- Sect. 6. Therapeutic and drug development. RNAi-mediated silencing of viral gene expression and replication -- RNAi in drug development: practical considerations -- RNA interference studies in liver failure -- RNAi applications in living animal systems -- Sect. 7. High-throughput genome-wide RNAi analysis. High-throughput RNAi by soaking in Caenorhabtis elegans -- Tools for integrative genomics: genome-wide RNAi and expression profiling in Drosophila -- Microarray analysis and RNA silencing to determine genes functionally important in mesothelioma -- High-throughput RNA interference -- Generation of highly specific vector-based shRNAi libraries directed against the entire human genome.
    Also available: Print – 2005
  • 2014 Springer Protocols
    edited by M. Lucrecia Alvarez, Mahtab Nourbakhsh.
    Part I Structural RNA mapping -- Full-length characterization of transcribed genomic region -- Rapid mapping of RNA 3 and 5 ends -- Single nucleotide mapping of RNA 5 and 3 ends -- Analysis of RNA secondary structure -- Tertiary structure mapping of the Pri-miRNA miR-17-92 -- In situ hybridization detection of miRNA using LNA [trademark] oligonucleotides -- Quantification of miRNAs by a simple and specific qPCR method -- RNA isolation for small RNA next-generation sequencing from acellular biofluids -- Sequencing small RNA : introduction and data analysis fundamentals -- Measuring expression levels of small regulatory RNA molecules from body fluids and formalin-fixed, paraffin-embedded samples -- MicroRNA profiling in plasma or serum using quantitative RT-PCR -- MicroRNA profiling of exosomes isolated from biofluids and conditioned media -- Isolation of urinary exosomes for RNA biomarker discovery using a simple, fast, and highly scalable method -- Part II Functional RNA mapping -- Identification of actively translated mRNAs -- Mapping of internal ribosome entry sites (IRES) -- Mapping of protein binding RNA elements -- Purification of RNA-binding proteins -- De novo approach to classify protein-coding and noncoding transcripts based on sequence composition -- Computational methods to predict long noncoding RNA functions based on co-expression network -- MicroRNA biogenesis : dicing assay -- Faster experimental validation of microRNA targets using cold fusion cloning and a dual firefly-Renilla luciferase reporter assay -- Experimental validation of predicted mammalian microRNAs of mirtron origin -- A guide for miRNA target prediction and analysis using web-based applications -- Tapping microRNA regulation networks through integrated analysis of microRNA-mRNA high-throughput profiles -- miRWalk database for miRNA-target interactions -- A schematic workflow for collecting information about the interaction between copy number variants and microRNAs using existing resources -- SYBR green and TaqMan quantitative PCR arrays : expression profile of genes relevant to a pathway or a disease state -- Comprehensive meta-analysis of microRNA expression using a robust rank aggregation approach.
  • 2012 Springer
    Albrecht Bindereif, editor.
    1. RNA polymerases and transcription factors of trypanosomes / Arthur Günzl -- 2. SL RNA biogenesis in kinetoplastids: a long and winding road / Nancy R. Sturm, Jesse R. Zamudio, and David A. Campbell -- 3. Pre-mRNA splicing in trypanosoma brucei: factors, mechanisms, and regulation / Christian Preusser, Nicolas Jaé, Arthur Günzl, and Albrecht Bindereif -- 4. mRNA turnover in trypanosomes / Christine Clayton -- 5. tRNA biogenesis and processing / Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, and Juan D. Alfonzo -- 6. rRNA biogensis in trypanosomes / Shulamit Michaeli -- 7. RNA editing in African trypanosomes: a U-ser's G-U-ide / H. Ulrich Göringer -- 8. The RNA interference pathway in trypanosoma brucei / Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, and Christian Tschudi -- 9. Translation in trypanosomatids -- 10. Mitochondrial translation in trypanosomatids / Dmitri A. Maslov and Rajendra K. Agrawal -- 11. RNA-Seq analysis of the transcriptome of trypanosoma brucei / Jan Mani, Kapila Gunasekera, and Isabel Roditi.
  • 2010 ScienceDirect
    Robert E. Farrell Jr.
    RNA and the cellular biochemistry revisited -- RNA isolation strategies -- The truth about tissues -- Going green : RNA and the molecular biology of plants -- Isolation of polyadenylated RNA -- Quality control for RNA preparations -- Resilient ribonucleases -- Stringency : conditions that influence nucleic acid structure -- Electrophoresis of RNA -- Photodocumentation and image analysis -- Northern analysis -- Nucleic acid probe technology -- Practical nucleic acid hybridization -- Principles of detection -- Quantifications of specific mRNAs by nuclease protection -- Analysis of nuclear RNA -- cDNA synthesis -- RT-PCR : a science and an art form -- Quantitative PCR techniques -- Functional genomics and transcript profiling -- High-throughput analysis of gene expression -- Non-array methods for global analysis of gene expression -- RNAi : take a RISC-role the dicer -- Genomes, transcriptomes, proteomes, and bioinformatics -- An RNA paradigm.
  • 2015 ScienceDirect
    He, Chuan.
    Methodology for the high-throughput identification and characterization of tRNA variants that are substrates for a tRNA decay pathway -- Nucleoside analysis by hydrophilic interaction liquid chromatography coupled with mass spectrometry -- A platform for discovery and quantification of modified ribonucleosides in RNA: application to stress-induced reprogramming of tRNA modifications -- Recogniion of specified RNA modifications by the innate immune system -- Kinetic analysis of tRNA methyltransferases -- Preparation of human nuclear RNA m6A methyltransferases and demethylases and biochemical characterization of their catalytic activity -- Transcriptome-wide mapping of N6-methyladenosine by m6A-Seq -- Probing RNA modification status at single-nucleotide resolution in total RNA -- High-resolution mapping of N6-methyladenosine in transcriptome and genome using a photo-crosslinking-assisted strategy -- Pseudouridine in mRNA: incorporation, detection, and recoding -- Pseudo-Seq: genome-wide detection of pseudouridine modifications in RNA -- Pseudouridine chemical labeling and profiling -- Experimental approaches for target profiling of RNA cytosine methyltranferases -- RNA 5-methylcytosine analysis by bisulfite sequencing -- Biochemical and transcriptome-wide identification of A-to-I RNA editing sites by ICE-Seq -- Radical SAM-mediated methylation of ribosomal RNA.
  • 2007 ScienceDirect
    edited by Jonatha M. Gott.
    Also available: Print – 2007
  • 2014 CRCnetBASE
    edited by Peixuan Guo, Farzin Haque.
    Section 1. Introduction : principles and fundamentals of RNA nanotechnology -- section 2. RNA folding, structure, and motifs in RNA nanoparticle assembly -- section 3. RNA computation and structure prediction for RNA nanoparticle construction -- section 4. RNA chemistry for nanoparticle synthesis, conjugation, and labeling -- section 5. Single-molecule and biophysical techniques in RNA nanostructure analysis -- section 6. Methods for the assembly of RNA nanoparticles -- section 7. RNA nanoparticles for therapy of cancer, viral infections, and genetic diseases -- section 8. RNA nanotechnology for diagnostic applications -- section 9. Application of RNA aptamers in RNA nanotechnology and therapeutics -- section 10. Application of miRNAs in RNA nanotechnology and therapeutics -- section 11. Application of siRNAs in RNA nanotechnology and therapeutics.
  • 2015 Springer Protocols
    edited by Peixuan Guo, Farzin Haque.
  • pt. C-D, 2003. ScienceDirect
    pt. D ScienceDirect
    edited by Sankar Adhya, Susan Garges.
    Also available: Print – pt. C-D, 2003.
  • 2016 Springer
    Gene W. Yeo, editor.
    Ribonucleic acid (RNA) binding proteins currently number in the thousands and defects in their function are at the heart of diseases such as cancer and neurodegeneration. RNA binding proteins have become implicated in the intricate control of surprisingly diverse biological settings, such as circadian rhythm, stem cell self-renewal, oncogenesis and germ cell development. This book surveys a range of genome-wide and systems approaches to studying RNA binding proteins, the importance of RNA binding proteins in development, cancer and circadian rhythm. .
  • ScienceDirect
    edited by James E. Dahlberg, John N. Abelson.
    Also available: Print – 1989
  • ScienceDirect
    edited by James E. Dahlberg, John N. Abelson.
    Also available: Print – 1990
  • 2015 Springer Protocols
    edited by Marc Boudvillain.
  • 2015 Springer Protocols
    edited by Luc Ponchon.
    Method to predict the 3D structure of an RNA scaffold / Xiaojun Xu and Shi-Jie Chen -- Post-crystallization improvement of RNA crystal diffraction quality / Jinwei Zhang and Adrian R. Ferré-D'Amaré -- Expression and purification of RNA-protein complexes in Escherichia coli / Margueritte El Khouri and others -- Production of homogeneous recombinant RNA using a tRNA scaffold and hammerhead ribozymes / Frank H.T. Nelissen, Hans A. Heus, and Sybren S. Wijmenga -- In vivo production of small recombinant RNAs embedded in a 5S rRNA-derived protective scaffold / Victor G. Stepanov and George E. Fox -- Detection of RNA-protein interactions using tethered RNA affinity capture / Hidekazu Iioka and Ian G. Macara -- Universal method for labeling native RNA in live bacterial cells / Irina Smolina and Natalia Broude -- Live cell imaging using riboswitch-spinach tRNA fusions as metabolite-sensing fluorescent biosensors / Colleen A. Kellenberger, Zachary F. Hallberg, and Ming C. Hammond -- RNA scaffold : designed to co-localize enzymes / ZJU_China Team (iGEM 2012) and Ming Chen -- Artificial ligase ribozymes isolated by a "Design and Selection" strategy / Shigeyoshi Matsumura and Yoshiya Ikawa -- Engineering aptazyme switches for conditional gene expression in mammalian cells utilizing an in vivo screening approach / Charlotte Rehm, Benedikt Klauser, and Jörg S. Hartig -- Aptazyme-based riboswitches and logic gates in mammalian cells / Yoko Nomura and Yohei Yokobayashi -- Design and characterization of topological small RNAs / Jack Hassall and others -- Folding RNA-protein complex into designed nanostructures / Tomonori Shibata and others -- Simple method for constructing RNA triangle, square, pentagon by tuning interior RNA 3WJ angle from 60° to 90° or 108° / Emil F. Khisamutdinov and others -- RNA-mediated CdS-based nanostructures / Vinit Kumar and Anil Kumar -- Effective method for specific gene silencing in Escherichia coli using artificial small RNA / Geunu Bak and others.
  • 2014 Springer Protocols
    edited by Jan Gorodkin, Walter L. Ruzzo.
    The existence of genes for RNA molecules not coding for proteins (ncRNAs) has been recognized since the 1950's, but until recently, aside from the critically important ribosomal and transfer RNA genes, most focus has been on protein coding genes. However, a long series of striking discoveries, from RNA's ability to carry out catalytic function, to discovery of riboswitches, microRNAs and other ribo-regulators performing critical tasks in essentially all living organisms, has created a burgeoning interest in this primordial component of the biosphere. However, the structural characteristics and evolutionary constraints on RNA molecules are very different from those of proteins, necessitating development of a completely new suite of informatic tools to address these challenges. In RNA Sequence, Structure, Function: Computational and Bioinformatic Methods, expert researchers in the field describe a substantial and relevant fraction of these methodologies from both practical and computational/algorithmic perspectives. Focusing on both of these directions addresses both the biologist interested in knowing more about RNA bioinformatics as well as the bioinformaticist interested in more detailed aspects of the algorithms. Written in the highly successful Methods in Molecular Biology series format, the chapters include the kind of detailed description and implementation advice that is crucial for getting optimal results. Thorough and intuitive, RNA Sequence, Structure, Function: Computational and Bioinformatic Methods aids scientists in continuing to study key methods and principles of RNA bioinformatics.
  • 2005 Springer Protocols
    edited by Gordon G. Carmichael.
    Detection of microRNAs and assays to monitor microRNA activities in vivo and in vitro / Marianthi Kiriakidou ... [et al.] -- High-throughput analysis of microRNA gene expression using sensitive probes / Mouldy Sioud and Øystein Røsok -- Modification of human U1 snRNA for inhibition of gene expression at the level of pre-mRNA / Peng Liu ... [et al.]. Identification of components of RNAi pathways using the tandem affinity purification method / Mikiko C. Siomi and Haruhiko Siomi -- Separation of Drosophila RNA silencing complexes by native gel electrophoresis / John W. Pham and Erik J. Sontheimer -- Preparation and analysis of drosha / Yoontae Lee and V. Narry Kim -- RNA interference in Caenorhabditis elegans / Nathaniel R. Dudley and Bob Goldstein -- Down-regulating gene expression by RNA interference in Trypanosoma brucei / Christine E. Clayton ... [et al.] -- Analysis of double-stranded RNA and small RNAs involved in RNA-mediated transcriptional gene silencing / M. Florian Mette ... [et al.] -- Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs / Mouldy Sioud and Sébastien Wälchli -- Silencing gene expression with dicer-generated siRNA pools / Jason W. Myers and James E. Ferrell Jr. -- Inhibition of gene expression in vivo using multiplex siRNA / Sung-Suk Chae and Timothy Hla -- Gene silencing by a DNA vector based RNAi technology / Guangchao Sui and Yang Shi -- Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors / Scott Q. Harper and Beverly L. Davidson -- SiRNA delivery in vivo / Mouldy Sioud -- Peptide-based strategy for siRNA delivery into mammalian cells / Federica Simeoni ... [et al.] -- Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells / Mingjie Li and John J. Rossi -- Exon-specific RNA interference: a tool to determine the functional relevance of proteins encoded by alternatively spliced mRNAs / Alicia M. Celotto, Joo-Won Lee, and Brenton R. Graveley -- Immunoprecipitation of microRNPs and directional cloning of microRNAs / Elisavet Maniataki, Maria Dels Angels De Planell Saguer, and Zissimos Mourelatos --
  • 2010 Springer
    Volker A. Erdmann, Jan Barciszewski, editors.
    The key features of RNA silencing / Kuniaki Saito ... [et al.] -- Selected strategies for the delivery of siRNA in vitro and in vivo / Sandra D. Laufer ... [et al.] -- RNAi suppression and its application / Xiaoping Yi, Rui Lu -- Strategies to prevent siRNA-triggered cellular toxicity / Matthias Bauer -- RNAi in malignant brain tumors: relevance to molecular and translational research / Mitsutoshi Nakada ... [et al.] -- Silencing Huntington's disease gene with RNAi / Yu Zhang, Robert M. Friedlander -- Application of Dicer-substrate siRNA in pain research / Philippe Sarret ... [et al.] -- RNAi treatment of HIV-1 infection / Karin J. von Eije, Ben Berkhout -- Application of RNA interference to treat conditions associated with dysregulation of transient receptor potential vanilloid 1 channel / Vickram Ramkumar ... [et al.] -- Harnessing RNAi-based functional genomics to unravel the molecular complexity underlying skin pigment variation / Hsiang Ho ... [et al.] -- mRNA structure and its effects on posttranscriptional gene silencing / Stephen I. Rudnick, Veenu Aishwarya, Alan M. Gewirtz -- Antisense RNA-mediated regulation of the p53 tumor suppressor / Marianne Farnebo, Klas G. Wiman -- Antisense oligonucleotides: insights from preclinical studies and clinical trials / Doreen Kunze, Kai Kraemer, Susanne Fuessel -- What can the new hammerhead ribozyme structures teach us about design? / William G. Scott -- microRNA biogenesis and its impact on RNA interference / Stefanie Grund, Sven Diederichs -- MicroRNAs in epithelial antimicrobial immunity / Jun Liu ... [et al.] -- Emerging roles of long noncoding RNAs in gene expression and intracellular organization / Tetsuro Hirose -- Noncoding RNAs as therapeutic targets / Maciej Szymański, Jan Barciszewski -- Noncoding RNAs at H19/IGF2 locus: role in imprinting, gene expression, and associated pathologies / Nahalie Berteaux, Nathalie Spruyt, Eric Adriaenssens.
  • 2008 Springer
    edited by Volker A. Erdmann, Wolfgang Poller, Jan Barciszewski.
  • 2006 Springer
    contributors: A. Adler ... [et al.] ; editors: Volker Erdmann, Jürgen Brosius and Jan Barciszewski.
  • 2008 ScienceDirect
    edited by Lynne E. Maquat, Cecilia M. Arraiano.
    Also available: Print – 2008
  • 2008 ScienceDirect
    edited by Lynne E. Maquat, Megerditch Kiledjian.
    Also available: Print – 2008
  • 2008 ScienceDirect
    edited by Lynne E. Maquat, Megerditch Kiledjian.
    Also available: Print – 2008
  • edited by Raymond F. Gesteland, Thomas R. Cech, John F. Atkins.
  • 2008 Springer Protocols
    edited by Sailen Barik.
  • 2011 Springer Protocols
    edited by Hiroaki Kodama, Atsushi Komamine.
    Overview of plant RNAi / Yuichiro Watanabe -- Caveat of RNAi in plants : the off-target effect / Muthappa Senthil-Kumar and Kirankumar S. Mysore -- Plant gateway vectors for RNAi as a tool for functional genomic studies / Toshiya Muranaka -- Heat-inducible RNAi for gene functional analysis in plants / Frederic Masclaux and Jean-Philippe Galaud -- Gene function analysis by artificial microRNAs in Physcomitrella patens / Basel Khraiwesh [and others] -- Virus-induced gene silencing in ornamental plants / Cai-Zhong Jiang, Jen-Chih Chen, and Michael Reid -- Local RNA silencing mediated by agroinfiltration / Jutta Maria Helm, Elena Dadami, and Kriton Kalantidis -- Direct transfer of synthetic double-stranded RNA into protoplasts of Arabidopsis thaliana / Ha-il Jung, Zhiyang Zhai, and Olena K. Vatamaniuk -- Detection of long and short double-stranded RNAs / Toshiyuki Fukuhara [and others] -- Quantitative stem-loop RT-PCR for detection of microRNAs / Erika Varkonyi-Gasic and Roger P. Hellens -- Large-scale sequencing of plant small RNAs / William P. Donovan, Yuanji Zhang, and Miya D. Howell -- Computational prediction of plant miRNA targets / Ying-Hsuan Sun [and others] -- Bisulfite sequencing for cytosine-methylation analysis in plants / Nazmul Haque and Masamichi Nishiguchi -- Using nuclear run-on transcription assays in RNAi studies / Basel Khraiwesh -- Proteomic analysis of RNA interference induced knockdown plant / Sang Yeol Lee and Kyun Oh Lee -- Comparative analysis of phosphoprotein expression using 2D-DIGE / Tomoya Asano and Takumi Nishiuchi.
  • 2011 CRCnetBASE
    editors, R.K. Gaur, Yedidya Gafni, P. Sharma, V.K. Gupta.
    "RNA interference (RNAi) is a system within living cells that helps to control active genes and their activity level. Two types of small RNA molecules--microRNA (miRNA) and small interfering RNA (siRNA)--are central to RNA interference. The discovery of RNAi was preceded first by observations of transcriptional inhibition by antisense RNA expressed in transgenic plants and more directly by reports of unexpected outcomes in experiments performed by plant scientists in the U.S. and The Netherlands in the early 1990s. RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals."--Provided by publisher.
  • ScienceDirect
    edited by Daniel W. Celander, John N. Abelson.
    Also available: Print – 2000
  • ScienceDirect
    edited by Daniel W. Celander, John N. Abelson.