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  • The Importance of Rheumatic Diseases, The Satisfaction Of Caring For These Patients -- Pain, Disease and Suffering an Integrated Perspective -- The Structure and Function of the Musculoskeletal System Sources of Pain -- Diagnostic Strategy the Main Syndromes in Rheumatology -- The Standard Enquiry in Rheumatology -- The General Clinical Examination -- Regional Syndromes Neck Pain -- Regional Syndromes The Painful Shoulder -- Regional Syndromes The Elbow And Forearm -- Regional Syndromes the Wrist and Hand -- Regional Syndromes Low Back Pain -- Regional Syndromes The Hip -- Regional Syndromes The Knee -- Regional Syndromes the Foot and Ankle -- Generalized Pain Syndrome Fibromyalgia Osteoarthritis -- Inflammatory Arthritides Diagnostic Strategies -- Monoarthritis -- Chronic, Additive, Symmetrical, Peripheral Polyarthritis -- Chronic, Asymmetrical Oligo- Or Polyarthritis -- Chronic Proximal Oligoarthritis -- Arthritis of the Shoulder and Pelvic Girdles Polymyalgia Rheumatica -- Acute Oligo- or Polyarthritis Febrile Arthritis Arthritis with Mucocutaneous Manifestations -- Inflammatory Low Back Pain -- Systemic Syndromes Connective Tissue Diseases Vasculitis Raynaud's Phenomenon -- Osteoporotic Syndrome Osteoporosis -- Bone Syndrome Bone Diseases -- Rheumatic Symptoms in Children and Adolescents -- Treating Rheumatic Diseases, General Principles -- Drugs Commonly Used in Rheumatic Diseases.
  • 1. Diagnostic Training and Rheumatology Trees -- 2. Explanations of Figures and Case Reports with Individual Therapeutic Options -- 3. Index of Figures (Fig.) and CS with Syndromes (for Self-assessment) -- Appendix: Index of the Solutions to the Syndromes and Diagnostics (for Rapid Diagnosis).
  • Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
  • 1. Articular disorders -- 2. Diseases of the spine -- 3. Soft-tissue rheumatism and related disorders -- 4. Regional arthrological and musculoskeletal syndromes -- 5. Paraneoplastic syndromes (PNS) in rheumatology -- 6. Algorithms in articular and musculoskeletal disorders: integrated diagnostic screening program: staged diagnostics -- 7. Algorithms in arthrological and musculoskeletal disorders -- 8. General symptoms (BVAS = maximum of 3 out of 63 points) -- 9. Involvement of connective tissue structures -- 10. System-/organ involvement -- 11. (Auto) immunological phenomena and serological diagnostics -- 12. Treatment-induced and associated conditions and diseases -- 13. Integrated diagnostic screening program staged diagnostics -- 14. Algorithms for connective tissue disease and vasculitis.
  • Rhinoplasty 2012
    Surgical Anatomy and Physiology of the Nose -- Patient Assessment for Rhinoplasty -- Dynamics of Rhinoplasty -- Primary Rhinoplasty -- Variations in Nasal Osteotomy : Consequences and Technical Nuances -- Tip Sutures -- Achieving Optimal Tip Projection -- Elongation of the Short Nose -- Correction of the Overprojected Nose -- Rhinoplasty on Patients with Cleft Lip Nose Deformity -- Correction of Alar Rim Deformities -- Alar Base Surgery -- Controlling the Nostril Size -- Rhinoplasty and Time Element -- Correcting the Nasal Deformity Resulting from Cocaine Insufflation -- Rhinoplasty in Patients with Thick Skin -- Correcting Deviated Noses, Septoplasty and Turbinectomy -- Rhinoplasty and Ethnicity -- Secondary Rhinoplasty -- Prevention and Management of Rhinoplasty Complications -- Rhinogenic Migraine Headaches.
  • RHO family GTPases 2005
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    "During the Civil War, Union soldiers and Confederate prisoners convalesced in a general army hospital in Portsmouth Grove, Rhode Island. This study details experiences of those who received and provided care, exploring the barbarities of medicine, daily routine, role of citizens, later adventures of former patients/staff, and final resting places of those who died on the grounds"--Provided by publisher.
  • Rhodiola rosea 2014
    Chapter 1. Taxonomy of Rhodiola rosea L., with special attention to molecular analyses of Nunavik (Québec) populations / Alain Cuerrier, Mariannick Archambault, Michel Rapinski, and Anne Bruneau -- Chapter 2. Ethnobotany and conservation of Rhodiola species / Alain Cuerrier, Youri Tendland, and Michel Rapinski -- Chapter 3. Phytochemistry of Rhodiola rosea / Fida Ahmed, Vicky Filion, Ammar Saleem, and John T. Arnason -- Chapter 4. Cultivation of Rhodiola rosea in Europe / Bertalan Galambosi -- Chapter 5. Rhodiola rosea cultivation in Canada and Alaska / Kwesi Ampong-Nyarko -- Chapter 6. Diseases of wild and cultivated Rhodiola rosea / Sheau-Fang Hwang, Stephen E. Strelkov, Kwesi Ampong-Nyarko, and Ron J. Howard -- Chapter 7. Biotechnology of Rhodiola rosea / Zsuzsanna György -- Chapter 8. Pharmacological activities of Rhodiola rosea / Fida Ahmed, Steffany A.L. Bennett, and John T. Arnason -- Chapter 9. Evidence-based efficacy and effectiveness of Rhodiola SHR-5 extract in treating stress- and age- associated disorders / Alexander Panossian and Georg Wikman -- Chapter 10. Rhodiola rosea in psychiatric and medical practice / Patricia L. Gerbarg, Petra A. Illig, and Richard P. Brown -- Chapter 11. Toxicology and safety of Rhodiola rosea / Hugh Semple and Brandie Bugiak -- Chapter 12. Commercialization of Rhodiola rosea / Nav Sharma and Raimar Loebenberg.
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    Structure defines function -- Diversity of cortical functions is provided by inhibition -- Windows on the brain -- A system of rhythms -- Synchronization by oscillation -- The brain's default state -- Perturbation of the default patterns by experience -- The gamma buzz -- Perceptions and actions are brain state-dependent -- Oscillations in the "other cortex" -- Coupling of systems by oscillations -- Tough problems.
  • Ribonuclease P 2010
    History of RNase P and Overview of Its Catalytic Activity -- The Evolution of RNase P and Its RNA -- Over a Decade of Bacterial Ribonuclease P Modeling -- Structural Studies of Ribonuclease P -- Folding of Bacterial RNase P RNA -- Kinetic Mechanism of Bacterial RNase P -- Roles of Metal Ions in RNase P Catalysis -- Challenges in RNase P Substrate Recognition: Considering the Biological Context -- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives -- Eukaryote RNase P and RNase MRP -- RNase P from Organelles -- Human RNase P and Transcription -- RNase P as a Drug Target -- Ribonuclease P as a Tool.
  • Ribonucleases 2011
  • Ribonucleases. Part A-B pt. A-B, 2001.
    pt. B ScienceDirect
  • Ribosomes
  • The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
  • This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers research methods in biomineralization scienceContains sections on such topics as riboswitch discovery and valid.
  • Published in association with the Society for Vascular Surgery (SVS), the newly updated edition of Rich's Vascular Trauma draws on civilian and military authorities from around the world to offer comprehensive and up-to-date coverage of the management of vascular injury. Anatomic patterns of vascular trauma including extremity, torso and cervical injury are reviewed in detail, including the latest techniques to manage non-compressible torso hemorrhage. You'll have access to all of the current innovations across the broad spectrum of vascular trauma, presented in a well-organized fashion that allows you to quickly hone-in on the most important issues in patient care and management.
  • Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.
  • Right heart 2014
    "This comprehensive book describes the structure, function and imaging of the normal right heart both at rest and under the stresses of high altitude and exercise. It continues with a detailed examination of the pathophysiology and pathobiology of right heart dysfunction, both in experimental models and human disease, including congenital heart disease. Right heart dysfunction caused by pulmonary hypertension is discussed in particular detail. The Right Heart brings together a distinguished group of contributors to discuss the advances in the topic that have occurred over the last few years and provides a concise and up-to-date resource for clinicians by compiling this comprehensive state-of-the-art text on the subject, the Editors have created an indispensable reference for future work by those interested in the cardiopulmonary circuit. This book will appeal to respiratory physicians, cardiologists and intensivists, all of whom will share the Editors' belief that the right heart is fundamental to integrated cardiopulmonary performance."
  • Introduction / Massimo Chessa and Alessandro Giamberti -- Anatomy of Tetralogy of Fallot / Carla Frescura and Gaetano Thiene -- Genetics / M. Cristina Digilio, Bruno Dallapiccola and Bruno Marino -- Stem Cells and the Right Ventricle / Luigi Anastasia and Marco Piccoli -- Pathophysiology in Tetralogy of Fallot / Gabriele Egidy Assenza and Michael J. Landzberg -- Tetralogy of Fallot: Late Outcome / Jochen Weil -- Tetralogy of Fallot: the Failing Right Ventricle / Folkert J. Meijboom and Barbara Mulder -- Imaging Evaluation / Claudio Bussadori -- Timing for RVOT Management / Harald Kaemmerer, Andreas Eicken and John Hess -- Percutaneous Pulmonary Valve / Mark S. Turner, Mario Carminati and Philipp Bonhoeffer -- Other Transcatheter Procedures / Massimo Chessa and Gianfranco Butera -- Surgical Pulmonary Valve Implantation / Alessandro Giamberti, Giuseppe Pomè and Alessandro Frigiola -- Other Surgical Procedures / Alessandro Giamberti -- Late Arrhythmias: Current Approaches / Sara Foresti, Maria Cristina Tavera, Pierpaolo Lupo and Riccardo Cappato -- Perioperative Right Ventricular Management / Marco Ranucci.
  • The Right Ventricle in Health and Disease provides a comprehensive and up-to-date database and collection of the available information which describes the structure and function of the normal right ventricle. The right ventricular performance and function reserve has now finally moved to the center of the stage as clinicians recognize that the drugs presently used to treat patients with severe pulmonary hypertension do not necessarily improve the performance of the right ventricle and because the survival depends on the right ventricular function that treatment strategies need to be developed to primarily protect the right ventricle from failing. In-depth chapters discuss right heart function and failure in patients with congenital heart diseases, review modern imaging techniques used to describe right ventricular form and function in patients with right heart failure (including cardiac MRI and PET scanning), describe ventricular interdependence: the left ventricle in pulmonary hypertension and discuss the concept of the sick lung circulation and its contribution to right heart failure. Treatment strategies of chronic right heart failure including drugs and mechanical devices are also discussed.
  • Decisions -- The injury -- Coming to terms with brain injury -- The origins of the vegetative state -- A shift since Quinlan -- Maggie's wishes -- Something happened in Arkansas -- From PVS to MCS -- Leaving the hospital -- Heather's story -- Neuroimaging and neuroscience in the public mind -- Contractures and contradictions : medical necessity and the injured brain -- Minds, monuments, and moments -- Heads and hearts, toil and tears -- What do families want? -- Deep brain stimulation in MCS -- Mending our brains, minding our ethics -- It's still freedom -- Maggie's in town -- When consciousness becomes prosthetic -- The rights of mind -- A call for advocacy.
  • The distribution and biogeography of the ringtailed lemur (Lemur catta) in Madagascar / Steven M. Goodman, Soava V. Rakotoarisoa and Lucienne Wilmé -- A preliminary estimate of Lemur catta population density using satellite imagery / Robert W. Sussman ... [et al.] -- Berenty Reserve : a research site in southern Madagascar / Alison Jolly ... [et al.] -- Beza Mahafaly Special Reserve : a research site in southwestern Madagascar / Robert W. Sussman and Joelisoa Ratsirarson -- Plant species fed on by Lemur catta in gallery forests of the southern domain of Madagascar / Bruno Simmen ... [et al.] -- Tamarind recruitment and long-term stability in the gallery forest at Berenty, Madagascar / Kathryn Blumenfeld-Jones ... [et al.] -- Home ranges of ringtailed lemur troops and the density of large trees at Berenty Reserve, Madagascar / Naoki Koyama ... [et al.] -- The influence of tamarind tree quality and quantity on Lemur catta behavior / Anne S. Mertl-Millhollen ... [et al.] -- Feeding competition between introduced Eulemur fulvus and native Lemur catta during the birth season at Berenty Reserve, southern Madagascar / Susan Pinkus, James N.M. Smith and Alison Jolly -- Tradition and novelty : Lemur catta feeding strategy on introduced tree species at Berenty Reserve / Takayo Soma -- Diet quality and taste perception of plant secondary metabolites by Lemur catta / B. Simmen ... [et al.] -- Territory as bet-hedging : Lemur catta in a rich forest and an erratic climate / Alison Jolly ... [et al.] -- Resource defense in Lemur catta : the importance of group size / R. Ethan Pride ... [et al.] -- Social changes in a wild population of ringtailed lemurs (Lemur catta) at Berenty, Madagascar / Shinichiro Ichino and Naoki Koyama -- Obsession with agonistic power / Michael. E. Pereira -- Male and female ringtailed lemurs' energetic strategy does not explain female dominance / Hantanirina Rasamimanana ... [et al.] -- Male sociality and integration during the dispersal process in Lemur catta : a case study / Lisa Gould -- Patterns of health, disease, and behavior among wild ringtailed lemurs, Lemur catta: effects of habitat and sex / Michelle L. Sauther ... [et al.] -- Bald lemur syndrome and the miracle tree : alopecia associated with Leucaena leucocephala at Berenty Reserve, Madagascar / Graham C. Crawford ... [et al.] -- Temporal change in tooth size among ringtailed lemurs (Lemur catta) at the Beza Mahafaly Special Reserve, Madagascar : effects of an environmental fluctuation / Frank P. Cuozzo and Michelle L. Sauther.
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    Pt. 1. Alchemy and the occult in English cultural and political life. Introduction : alchemy and the occult in England ; The origins of English alchemy and sources for the study of alchemy in fourteenth-century England -- Pt. 2. The Astrology of the earth : the intellectual impact of alchemy in fourteenth-century England. Alchemy and science and philosophy ; Alchemy and the Church ; The Cultural impact of alchemy -- Pt. 3. The Political significance of alchemy. The accession of Edward III ; Alchemical themes in the kingship of Edward III ; Richard II the magus and boy king ; Richard II and the occult ; Conclusion : the Lancastrian reaction.
  • During the mid- to late-twentieth century, study of the physiology of the developing fetus and newborn infant evolved rapidly to become a major discipline in the biomedical sciences. Initially of interest from a standpoint of function of the placenta and oxygenation of the fetus, the field advanced to explore both normal functional mechanisms as well as pathophysiologic aspects of their regulation. Examples include studying the role and regulation of circulatory vascular anatomic shunts in oxygenation, cardiac function, certain aspects of asphyxia in the fetus and newborn infant, the role of fetal breathing movements, cyclic electroencephalographic activity, and analysis of electronic monitoring of fetal heart rate variability and its significance. Included in this book are reminisces of several dozen individuals who played a vital role in these developments. Overall, this survey considers a number of aspects of the development of the science of fetal and neonatal physiology, and its role in the greatly improved care of pregnant women and their newborn infants.
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    Reasons for risk adjustment / Lisa I. Iezzoni -- Getting started and defining terms / Lisa I. Iezzoni -- Range of risk factors / Lisa I. Iezzoni -- Windows of observation / Amy K. Rosen and Ann M. Borzecki -- Coded data from administrative sources / Lisa I. Iezzoni -- Clinical data from medical records and health information technologies / Lisa I. Iezzoni -- Data from patient surveys / Lisa I. Iezzoni and Karen Donelan -- Conceptual and practical issues in developing risk adjustment methods / Lisa I. Iezzoni -- Validity and reliability of risk adjustment methods / Lisa I. Iezzoni -- Empirically evaluating risk adjustment models / Michael Shwartz and Arlene S. Ash -- Estimating the effect of an intervention from observational data / Michael Shwartz and Arlene S. Ash -- Comparing outcomes across providers / Arlene S. Ash ... [et al.] -- Risk adjustment in pediatric populations / Karen Kuhlthau, Jeanne Van Cleave, and Timothy G. Ferris -- Risk adjustment for mental health care / Anthony P. Weiss and Mark A. Blais -- Risk adjustment and persons with disabilities / Lisa I. Iezzoni -- Risk adjustment for long-term care / Dan Berlowitz and Orna Intrator -- The role of risk adjustment in managing health care organizations / Jennifer Daley -- Final observations / Lisa I. Iezzoni.
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    Choleragenic Vibrio cholerae 01 and 0139 are the causative agent of cholera, a water-and-food-borne disease with epidemic and pandemic potential. This report focuses on the risk of acquiring cholera from warm-water shrimps in international trade. Shrimp is a very important export product from many developing countries but outbreaks of cholera in these countries can have devastating effects on the international markets for their food products. This volume looks at different approaches for assigning the risk associated with choleragenic V. Cholerae in warm-water shrimp in international trade. Qualitative and quantitative approaches to assessing risk were developed and compared and risk estimates were made using the available and relevant data. --Publisher's description.
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    Vibrio vulnificus is one of three pathogenic Vibrio spp. on which FAO and WHO have undertaken risk assessment work. This pathogen is associated primarily with raw oysters but can occur in a variety of seafood products. As well as causing gastrointestinal illness, V. vulnificus can cause primary septicaemia which is a serious and often fatal disease in individuals with chronic pre-existing conditions. This volume provides an approach for undertaking quantitative risk assessment of V. vulnificus in raw oysters. This risk assessment model was also developed to evaluate the effectiveness of various interventions strategies aimed at reducing V. vulnificus levels in oysters and therefore the associated risk of illness.--Publisher's description.
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  • Part 1 : General considerations -- Basic medical malpractice terminology -- The defense attorney -- The plaintiff's attorney -- The trial judge -- The medical expert -- Sequence of events in a medical malpractice lawsuit -- Informed consent -- The five most effective risk prevention strategies -- Revelation of adverse events and the conundrum of an apology -- Part 2 : Risk management in the ophthalmic subspecialties and related fields -- Anesthesia -- Cataract surgery -- Cornea : external disease and contact lenses -- Drugs -- Emergencies -- Glaucoma -- Neuroophthalmology -- Oncology -- Ophthalmic plastic surgery -- Pediatric ophthalmology -- Refractive corneal surgery -- Retina and vitreous -- Uveitis -- Part 3 : Personal and business considerations -- Physician and defendant : living and coping with a double life -- Medical malpractice insurance : selection of companies and policies.
  • "Risk, Liability and Malpractice: What Every Plastic Surgeon Need To Know" is your indispensable guide to maintaining a reputable, safe, successful plastic surgery practice. Authors Phil Haeck, MD and Mark Gorney, MD, two of the best-known and most trusted authorities on this subject, discuss every issue you need to consider, from which procedures carry the highest risk through claims arising from Medi-Spas and unique aspects of providing aesthetic surgery for male patients. Written in a concise and easy-to-read style, this is the book you need to make wise clinical and practice decisions, manage your patients' expectations, avoid complications, and deliver satisfying results. Effectively navigate your toughest legal issues! Must-read chapters include "The Most Risky Procedures in Plastic Surgery," "Claims Arising From Medi-Spas," and "The Unique Aspects of The Male Patient and Aesthetic Surgery." Get advice you can trust! Phil Haeck, MD has been writing Plastic Surgery News's "On Legal Grounds" column for more than five years and is the 2011/2012 president of ASPS. Mark Gorney, MD, a former ASPS president, is a founding member of The Doctors Company, now the country's largest malpractice insurance carrier, and has taught the basics in risk management to thousands of his colleagues. Read it quickly and put it to work in your practice! A concise, practical approach with minimal legal jargon presents the guidance you need in a way that is easy to understand and apply.
  • "Smoking light and low tar brands do not reduce the public health's burden from smoking."
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    Risk and medical innovation : a historical perspective / Thomas Schlich -- To assess and to improve : practitioners' approaches to doubts linked with medical innovations 1720-1920 / Ulrich Tröhler -- Anaesthesia and the evaluation of surgical risk in mid-nineteenth century Britain / Ian Burney -- Redemption, danger and risk : the history of anti-bacterial chemotherapy and the transformation of tuberculin / Christoph Gradmann -- "As safe as milk or sugar water" : perceptions of the risks and benefits of the BCG vaccine in the 1920s and 1930s in France and Germany / Christian Bonah -- From danger to risk : the perception and regulation of X-rays in Switzerland, 1896-1970 / Monika Dommann -- The population as patient : Alice Stewart and the controversy over low-level radiation in the 1950s / Sarah Dry -- To treat or not to treat : drug research and the changing nature of essential hypertension / Carsten Timmermann -- Hormones at risk : cancer and the medical uses of industrially-produced sex steroids in Germany, 1930-1960 / Jean-Paul Gaudillière -- Risk assessment and medical authority in operative fracture care in the 1960 and 1970s / Thomas Schlich -- Assessing the risk and safety of the pill : maternal mortality and the pill / Lara Marks -- Addressing uncertainties : the conceptualization of brain death in Switzerland 1960-2000 / Silke Bellanger and Aline Steinbrecher -- Risk on trial : the interaction of innovation and risk in cancer clinical trials / Peter Keating and Alberto Cambrosio -- BioRisk : interleukin-2 from laboratory to market in the United States and Germany / Arthur Daemmrich -- The redemption of Thalidomide : standardizing the risk of birth defects / Stefan Timmermans and Valerie Leiter.
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    The Heart of the matter : for one family with a five-year-old with chronic disease, normal life is the greatest gift / by Kathryn Roethel -- Bus to nowhere : for Silicon Valley's homeless population, Hotel 22 is an endless ride / by Miranda Simon -- The Good death : "No One Dies Alone" is a volunteer program and a promise / by Ryan Mac -- The Clean room : why did so many IBM employees come down with cancer after working in Silicon Valley? / by Lily Bixler -- Shelter from the storm : in a time of budgetary crisis, abused women still need help / by Kristen Barta -- Punched in the gut : can a family ever recover from an eating disorder? / by Erin Beresini.
  • RNA 2001
  • Introduction / Michael Levitt -- Modeling RNA Molecules / Neocles Leontis and Eric Westhof -- Methods for Predicting RNA Secondary Structure / Kornelia Aigner, Fabian Dre€en and Gerhard Steger -- Why Can't We Predict RNA Structure At Atomic Resolution? / Parin Sripakdeevong, Kyle Beauchamp and Rhiju Das -- Template-Based and Template-Free Modeling of RNA 3D Structure: Inspirations from Protein Structure Modeling / Kristian Rother, Magdalena Rother, Michał Boniecki, Tomasz Puton and Konrad Tomala, et al. -- The RNA Folding Problems: Different Levels of sRNA Structure Prediction / Fredrick Sijenyi, Pirro Saro, Zheng Ouyang, Kelly Damm-Ganamet and Marcus Wood, et al. -- Computational Prediction and Modeling Aid in the Discovery of a Conformational Switch Controlling Replication and Translation in a Plus-Strand RNA Virus / Wojciech K. Kasprzak and Bruce A. Shapiro -- Methods for Building and Refining 3D Models of RNA / Samuel C. Flores, Magdalena Jonikas, Christopher Bruns, Joy P. Ku and Jeanette Schmidt, et al. -- Multiscale Modeling of RNA Structure and Dynamics / Feng Ding and Nikolay V. Dokholyan -- Statistical Mechanical Modeling of RNA Folding: From Free Energy Landscape to Tertiary Structural Prediction / Song Cao and Shi-Jie Chen -- Simulating Dynamics in RNA-Protein Complexes / John Eargle and Zaida Luthey-Schulten -- Quantum Chemical Studies of Recurrent Interactions in RNA 3D Motifs / Jiří Šponer, Judit E. Šponer and Neocles B. Leontis -- Nonredundant 3D Structure Datasets for RNA Knowledge Extraction and Benchmarking / Neocles B. Leontis and Craig L. Zirbel -- Ions in Molecular Dynamics Simulations of RNA Systems / Pascal Auffinger -- Modeling RNA Folding Pathways and Intermediates Using Time-Resolved Hydroxyl Radical Footprinting Data / Joshua S. Martin, Paul Mitiguy and Alain Laederach -- A Top-Down Approach to Determining Global RNA Structures in Solution Using NMR and Small-Angle X-ray Scattering Measurements / Yun-Xing Wang, Jinbu Wang and Xiaobing Zuo -- RNA Structure Determination by Structural Probing and Mass Spectrometry: MS3D / A. E. Hawkins and D. Fabris.
  • RNA and cancer 2013
    Coupling Between Transcription and Alternative Splicing / Ignacio E. Schor, Luciana I. Gómez Acuña, Alberto R. Kornblihtt -- Detection of Alternatively Spliced or Processed RNAs in Cancer Using Oligonucleotide Microarray / Marieta Gencheva ... [et al.] -- Cancer-Associated Perturbations in Alternative Pre-messenger RNA Splicing / Lulzim Shkreta ... [et al.] -- Alternative Splicing of Tumor Suppressors and Oncogenes / Claudia Ghigna, Silvano Riva, Giuseppe Biamonti -- MicroRNAs in Cancer / Jianzhong Jeff Xi -- The Perinucleolar Compartment: RNA Metabolism and Cancer / John T. Norton, Sui Huang -- Regulation of ARE-mRNA Stability by Cellular Signaling: Implications for Human Cancer / Christian Kroun Damgaard, Jens Lykke-Andersen -- Alternative Pre-mRNA Splicing, Cell Death, and Cancer / Kong Ruirui ... [et al.] -- Oligonucleotide Therapeutics in Cancer / Jing Wan, John A. Bauman, Maria Anna Graziewicz, Peter Sazani -- Clinical Perspective on Chemo-Resistance and the Role of RNA Processing / Nancy L. Krett, Shuo Ma, Steven T. Rosen.
  • Three-dimensional reconstruction of trypanosoma brucei editosomes using single-particle electron microscopy / H.U. Goringer ... [et al.] -- Icoda: RNAi-based inducible knock-in system in trypanosoma brucei / G.E. Ringpis, R.H. Lathrop and R. Aphasizhev -- Perturbing a-to-i RNA editing using genetics and homologous recombination / C.J. Staber ... [et al.] -- Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis / H. Sun ... [et al.] -- Biochemical identification of A-to-I RNA editing sites by the inosine chemical erasing (ice) method / M. Sakurai and T. Suzuki -- Identifying mRNA editing deaminase targets by RNA-seq / B.R. Rosenberg, S. Dewell and F.N. Papavasiliou -- Mouse and other rodent models of C to U RNA editing / V. Blanc and N.O. Davidson -- In vivo analysis of RNA editing in plastids / S. Ruf and R. Bock -- Identifying specific trans-factors of RNA editing in plant mitochondria by multiplex single base extension typing / M. Takenaka -- Complementation of mutants in plant mitochondrial RNA editing by protoplast transfection / M. Takenaka and A. Zehrmann -- A high-throughput assay for DNA deaminases / M. Wang, C. Rada and M.S. Neuberger -- Biochemical fractionation and purification of high-molecular-mass apobec3g complexes / Y.L. Chiu -- Analysis of tRNA editing in native and synthetic substrates / J.L. Spears, K.W. Gaston and J.D. Alfonzo -- Post-transcriptional modification of RNAs by artificial box h/aca and box c/d rnps / C. Huang, J. Karijolich and Y.T. Yu -- Functional analysis of noncoding RNAs in trypanosomes: RNA walk, a novel approach to study RNA-RNA interactions between small RNA and its target / C. Wachtel and S. Michaeli -- A post-labeling approach for the characterization and quantification of RNA modifications based on site-directed cleavage by dnazymes / M. Meusburger, M. Hengesbach and M. Helm.
  • Single molecule imaging of RNA in situ / Mona Batish, Arjun Raj, and Sanjay Tyagi -- FISH and immunofluorescence staining in Chlamydomonas / James Uniacke, Daniel Colón-Ramos, and William Zerges -- High resolution fluorescent in situ hybridization in Drosophila / Eric Lécuyer -- Localization and anchorage of maternal mRNAs to cortical structures of ascidian eggs and embryos using high resolution in situ hybridization / Alexandre Paix, Janet Chenevert, and Christian Sardet -- Visualization of mRNA localization in Xenopus oocytes / James A. Gagnon and Kimberly L. Mowry -- Visualization of mRNA expression in the zebrafish embryo / Yossy Machluf and Gil Levkowitz -- High-resolution fluorescence in situ hybridization to detect mRNAs in neuronal compartments in vitro and in vivo / Sharon A. Swanger, Gary J. Bassell, and Christina Gross -- Localization of mRNA in vertebrate axonal compartments by in situ hybridization / José Roberto Sotelo-Silveira ... [et al.] -- Tiny molecular beacons for in vivo mRNA detection / Diana P. Bratu, Irina E. Catrina, and Salvatore A.E. Marras -- Delivery of molecular beacons for live-cell imaging and analysis of RNA / Antony K. Chen ... [et al.] -- Genetically-encoded fluorescent probes for imaging endogenous mRNA in living cells / Takeaki Ozawa and Yoshio Umezawa -- Visualization of induced RNA in single bacterial cells / Azra Borogovac and Natalia E. Broude -- Visualizing mRNAs in fixed and living yeast cells / Franck Gallardo and Pascal Chartrand -- In vivo visualization of RNA using the U1A-based tagged RNA system / Sunglan Chung and Peter A. Takizawa -- Visualizing endogenous mRNAs in living yeast using m-TAG, a PCR-based RNA aptamer integration method, and fluorescence microscopy / Liora Haim-Vilmovsky and Jeffrey E. Gerst -- Imaging mRNAs in living mammalian cells / Sharon Yunger and Yaron Shav-Tal -- Using the mRNA-MS2/MS2CP-FP system to study mRNA transport during Drosophila oogenesis / Katsiarina Belaya and Daniel St Johnston -- Genome-wide analysis of RNA extracted from isolated mitochondria / Erez Eliyahu, Daniel Melamed and Yoav Arava -- Analyzing mRNA localization to the endoplasmic reticulum via cell fractionation / Sujatha Jagannathan, Christine Nwosu and Christopher V. Nicchitta -- Isolation of mRNAs encoding peroxisomal proteins from yeast using a combined cell fractionation and affinity purification procedure / Gadi Zipor, Cecile Brocard and Jeffrey E. Gerst -- Profiling axonal mRNA transport / Dianna E. Willis and Jeffery L. Twiss -- RNA purification from tumor cell protrusions using porous polycarbonate filters / Jay Shankar and Ivan R. Nabi -- RNA-binding protein immunopurification-microarray (RIP-chip) analysis to profile localized RNAs / Alessia Galgano and André P. Gerber -- RaPID : an aptamer-based mRNA affinity purification technique for the identification of RNA and protein factors present in ribonucleoprotein complexes / Boris Slobodin and Jeffrey E. Gerst -- RIP : an mRNA localization technique / Sabarinath Jayaseelan ... [et al.] -- The dual use of RNA aptamer sequences for affinity purification and localization studies of RNAs and RNA-protein complexes / Scott C. Walker ... [et al.] -- Identifying and searching for conserved RNA localisation signals / Russell S. Hamilton and Ilan Davis -- Computational prediction of RNA structural motifs involved in post-transcriptional regulatory processes / Michal Rabani, Michael Kertesz, and Eran Segal.
  • RNA editing 2008
    Editing reactions from the perspective of RNA structure / Matthias Homann -- Editing of tRNA for structure and function / Juan D. Alfonzo -- RNA editing by adenosine deaminases that act on RNA (ADARs) / Michael F. Jantsch and Marie Öhman -- Insertion/deletion editing in Physarum polycephalum / Jonatha M. Gott and Amy C. Rhee -- RNA editing in plant mitochondria / Mizuki Takenaka ... [et al.] -- RNA editing in chloroplasts / Masahiro Sugiura -- Working together : the RNA editing machinery in Trypanosoma brucei / Jason Carnes and Kenneth Stuart -- RNA editing accessory factors : the example of mHel61p / H. Ulrich Göringer ... [et al.] -- The function of RNA editing in trypanosomes / Torsten Ochsenreiter and Stephen Hajduk -- Evolutionary aspects of RNA editing / Dave Speijer.
  • RNA editing 2007
  • RNA exosome 2011
    "The diversity of RNAs inside living cells is amazing. We have known of the more "classic" RNA species: mRNA, tRNA, rRNA, snRNA and snoRNA for some time now, but in a steady stream new types of molecules are being described as it is becoming clear that most of the genomic information of cells ends up in RNA. To deal with the enormous load of resulting RNA processing and degradation reactions, cells need adequate and efficient molecular machines. The RNA exosome is arising as a major facilitator to this effect. Structural and functional data gathered over the last decade have illustrated the biochemical importance of this multimeric complex and its many co-factors, revealing its enormous regulatory power. By gathering some of the most prominent researchers in the exosome field, it is the aim of the book to introduce this fascinating protein complex and to give a timely and rich account of its many functions"--Provided by publisher.
  • RNA helicases. 1st ed. 2012
    This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases. The contributions in this volume cover the broad scope of methods in the research on these enzymes. Several chapters describe quantitative biophysical and biochemical approaches to study molecular mechanisms and conformational changes of RNA helicases. Further chapters cover structural analysis, examination of co-factor effects on several representative examples, and the analysis of cellular functions of select enzymes. Two chapters outline approaches to the analysis of inhibitors that target RNA helicases. This volume of Methods in Enzymology aims to provide a reference for the diverse, powerful tools used to analyze RNA helicases The contributions in this volume cover the broad scope of methods in the research on these enzymes.
  • The RNA infrastructure : an introduction to ncRNA networks / Lesley J. Collins -- RNA interactions / Manja Marz and Peter F. Stadler -- Plant RNA silencing in viral defence / Vitantonio Pantaleo -- Micrornas as post-transcriptional machines and their interplay with cellular networks / Sarath Chandra Janga and Swathi Vallabhaneni -- Spatiotemporal aspects of microRNA-mediated gene regulation / Joris Pothof and Dik C. van Gent -- Spliceosomal RNA infrastructure : the network of splicing components and their regulation by miRNAs / Lesley J. Collins -- Construction, structure, and dynamics of post-transcriptional regulatory network directed by RNA binding proteins / Sarath Chandra Janga and Nitish Mittal -- Safe keeping the message : mRNP complexes tweaking after transcription / Said Hafidh, Věra Čapková, and David Honys -- Unexpected functions of tRNA and tRNA processing enzymes / Rebecca L. Hurto -- Programmed DNA elimination in tetrahymena : a small RNA mediated genome surveillance mechanism / Kensuke Kataoka and Kazufumi Mochizuki -- Long noncoding RNA and epigenomics / Chandrasekhar Kanduri -- Promoter associated long noncoding RNAs repress transcription through a RNA binding protein TLS / Riki Kurokawa -- RNA networks in prokaryotes I :CRISPRs and riboswitches / Patrick J. Biggs and Lesley J. Collins -- RNA networks in prokaryotes II : tRNA processing and small RNAs / Lesley J. Collins and Patrick J. Biggs -- Localization of the bacterial RNA infrastructure / Kenneth C. Keiler -- Small RNA discovery and characterisation in eukaryotes using high throughput approaches / Helio Pais ... [et al.] -- How old are RNA networks? / Toni Daly, X. Sylvia Chen, and David Penny.
  • RNA interference 2008
    RNA interference in mammalian cell systems / Patrick J. Paddison -- RNAi pathway in C. elegans: the argonautes and collaborators / Marie-Eve L. Boisvert and Martin J. Simard -- Genetics and biochemistry of RNAi in drosophila / Harsh H. Kavi ... [et al.] -- Role of dicer in posttranscriptional RNA silencing / Lukasz Jaskiewicz and Witold Filipowicz -- The mechanism of RNase III action: how dicer dices / Xinhua Ji -- MicroRNA metabolism in plants / Xuemei Chen -- Structure-function relationships among RNA-dependent RNA polymerases / Kenneth K.-S. Ng, Jamie J. Arnold, and Craig E. Cameron -- RNAi-mediated chromatin silencing in fission yeast / Sharon A. White and Robin C. Allshire -- A role for RNAi in heterochromatin formation in drosophila / Nicole C. Riddle and Sarah C.R. Elgin -- RNA mediated transcriptional gene silencing in human cells / Kevin V. Morris -- RNA silencing in mammalian oocytes and early embryos / Petr Svoboda -- Identifying human microRNAs / Isaac Bentwich.
  • RNA interference 2005
  • The Nobel Prize winning discovery that small interfering RNA can be utilised to control cellular gene expression has propelled the field of RNA interference (RNAi) to the forefront of biomedical science as a potential molecular medicine set to revolutionalise disease treatment. Harnessing the molecular mechanisms of RNAi and development of delivery technologies is crucial for its transformation into a therapeutic modality, this dependency is the focus of "RNA Interference from Biology to Therapeutics" that gives a comprehensive overview of RNAi biology and state-of-the-art delivery methods relevant to clinical translation of RNAi therapeutics. Key players and shapers in the fields of RNAi and delivery science have been assembled in a single volume to produce a truly unique interdisciplinary text, making it a "must-read" for both students and experts in, and at the interface of, RNAi, pharmaceutical science and medicine. An attractive feature is the "future perspectives" section within each chapter that allows global leaders the opportunity to express their views on the direction the field is moving. Topics covered in the book include miRNA biology and therapeutic exploitation, exosome delivery and clinical translation."RNA Interference from Biology to Therapeutics" is an up-to-the-minute, highly informative and invaluable text for those actively involved or interested in this fascinating and high-impact field.
  • Chemical modifications to achieve increased stability and sensitive detection of siRNA -- RNA interference in postimplantation mouse embryos -- In ovo RNAi opens new possibilities for functional genomics in vertebrates -- Sect. 4. Gene silencing in model organisms. Practical applications of RNAi in C. elegans -- Inducible RNAi as a forward genetic tool in Trypanosoma brucei -- RNA-mediated gene silencing in fission yeast -- RNA silencing in filamentous fungi: Mucor ciccinelloides as a model organism -- RNAi and gene silencing phenomena mediated by viral suppressors in plants -- Sect. 1. Basic RNAi, siRNA, microRNAs and gene-silencing mechanisms. RNAi beginnings. Overview of the pathway in C. elegans -- Dicer in RNAi: its roles in vivo and utility in vitro -- Genes required for RNA interference -- MicroRNAs: a small contribution from worms -- miRNAs in the brain and the application of RNAi to neurons -- Sect. 2. Design, synthesis of siRNAs. Degign and synthesis of small interfering RNA (siRNA) -- Automated design and high throughput chemical synthesis of siRNA -- Rational design of siRNAs with the Sfold software -- Enzymatic production of small interfering RNAs -- Sect. 3. Vector development and in vivo, in vitro and in ovo delivery methods. Six methods of inducing RNAi in mammalian cells -- Viral delivery of shRNA -- siRNA delivery by lentiviral vectors: design and applications -- Liposomal delivery of siRNAs in mice -- Sect. 5. Drug target validation. Delivering siRNA in vivo for functional genomics and novel therapeutics -- The role of RNA interference in drug target validation: application to Hepatitis C -- RNAi in the drug discovery process -- RNA interference technology in the discovery and validation of druggable targets -- Sect. 6. Therapeutic and drug development. RNAi-mediated silencing of viral gene expression and replication -- RNAi in drug development: practical considerations -- RNA interference studies in liver failure -- RNAi applications in living animal systems -- Sect. 7. High-throughput genome-wide RNAi analysis. High-throughput RNAi by soaking in Caenorhabtis elegans -- Tools for integrative genomics: genome-wide RNAi and expression profiling in Drosophila -- Microarray analysis and RNA silencing to determine genes functionally important in mesothelioma -- High-throughput RNA interference -- Generation of highly specific vector-based shRNAi libraries directed against the entire human genome.
  • 1. RNA polymerases and transcription factors of trypanosomes / Arthur Günzl -- 2. SL RNA biogenesis in kinetoplastids: a long and winding road / Nancy R. Sturm, Jesse R. Zamudio, and David A. Campbell -- 3. Pre-mRNA splicing in trypanosoma brucei: factors, mechanisms, and regulation / Christian Preusser, Nicolas Jaé, Arthur Günzl, and Albrecht Bindereif -- 4. mRNA turnover in trypanosomes / Christine Clayton -- 5. tRNA biogenesis and processing / Jessica L. Spears, Mary Anne T. Rubio, Paul J. Sample, and Juan D. Alfonzo -- 6. rRNA biogensis in trypanosomes / Shulamit Michaeli -- 7. RNA editing in African trypanosomes: a U-ser's G-U-ide / H. Ulrich Göringer -- 8. The RNA interference pathway in trypanosoma brucei / Elisabetta Ullu, Nikolay G. Kolev, Rebecca L. Barnes, and Christian Tschudi -- 9. Translation in trypanosomatids -- 10. Mitochondrial translation in trypanosomatids / Dmitri A. Maslov and Rajendra K. Agrawal -- 11. RNA-Seq analysis of the transcriptome of trypanosoma brucei / Jan Mani, Kapila Gunasekera, and Isabel Roditi.
  • RNA and the cellular biochemistry revisited -- RNA isolation strategies -- The truth about tissues -- Going green : RNA and the molecular biology of plants -- Isolation of polyadenylated RNA -- Quality control for RNA preparations -- Resilient ribonucleases -- Stringency : conditions that influence nucleic acid structure -- Electrophoresis of RNA -- Photodocumentation and image analysis -- Northern analysis -- Nucleic acid probe technology -- Practical nucleic acid hybridization -- Principles of detection -- Quantifications of specific mRNAs by nuclease protection -- Analysis of nuclear RNA -- cDNA synthesis -- RT-PCR : a science and an art form -- Quantitative PCR techniques -- Functional genomics and transcript profiling -- High-throughput analysis of gene expression -- Non-array methods for global analysis of gene expression -- RNAi : take a RISC-role the dicer -- Genomes, transcriptomes, proteomes, and bioinformatics -- An RNA paradigm.
  • RNA methods and protocols 2008
    Springer Protocols
    The transcriptional landscape -- Working with RNA -- Synthesis of RNA by in vitro transcription -- Efficient poly(A)+ RNA selection using LNA oligo(T) capture -- Genome browsers -- Web-based tools for studying RNA structure and function -- Northern blotting analysis -- Rapid amplification of cDNA ends (RACE) -- Fractionation of mRNA based on the length of the poly(A) tail -- Analysis of mutations that influence pre-mRNA splicing -- S1 nuclease analysis of alternatively spliced mRNA -- Promises and challenges in developing RNAi as a research tool and therapy -- Inhibition of gene function in mammalian cells using short-hairpin RNA (shRNA) -- Validation of RNAi by real time PCR -- Profiling RNA polymerase II using the fast chromatin immunoprecipitation method -- The post-transcriptional operon -- RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray (chip) profiling -- Isolation of RNP granules -- Electrophoretic mobility shift assay for characterizing RNA-protein interaction -- Polysome analysis and RNA purification from sucrose gradients -- Prediction of targets for microRNAs -- Outsourcing of experimental work.
  • RNA modification 2015
    Methodology for the high-throughput identification and characterization of tRNA variants that are substrates for a tRNA decay pathway -- Nucleoside analysis by hydrophilic interaction liquid chromatography coupled with mass spectrometry -- A platform for discovery and quantification of modified ribonucleosides in RNA: application to stress-induced reprogramming of tRNA modifications -- Recogniion of specified RNA modifications by the innate immune system -- Kinetic analysis of tRNA methyltransferases -- Preparation of human nuclear RNA m6A methyltransferases and demethylases and biochemical characterization of their catalytic activity -- Transcriptome-wide mapping of N6-methyladenosine by m6A-Seq -- Probing RNA modification status at single-nucleotide resolution in total RNA -- High-resolution mapping of N6-methyladenosine in transcriptome and genome using a photo-crosslinking-assisted strategy -- Pseudouridine in mRNA: incorporation, detection, and recoding -- Pseudo-Seq: genome-wide detection of pseudouridine modifications in RNA -- Pseudouridine chemical labeling and profiling -- Experimental approaches for target profiling of RNA cytosine methyltranferases -- RNA 5-methylcytosine analysis by bisulfite sequencing -- Biochemical and transcriptome-wide identification of A-to-I RNA editing sites by ICE-Seq -- Radical SAM-mediated methylation of ribosomal RNA.
  • RNA modification 2007
  • Section 1. Introduction : principles and fundamentals of RNA nanotechnology -- section 2. RNA folding, structure, and motifs in RNA nanoparticle assembly -- section 3. RNA computation and structure prediction for RNA nanoparticle construction -- section 4. RNA chemistry for nanoparticle synthesis, conjugation, and labeling -- section 5. Single-molecule and biophysical techniques in RNA nanostructure analysis -- section 6. Methods for the assembly of RNA nanoparticles -- section 7. RNA nanoparticles for therapy of cancer, viral infections, and genetic diseases -- section 8. RNA nanotechnology for diagnostic applications -- section 9. Application of RNA aptamers in RNA nanotechnology and therapeutics -- section 10. Application of miRNAs in RNA nanotechnology and therapeutics -- section 11. Application of siRNAs in RNA nanotechnology and therapeutics.
  • pt. D ScienceDirect
  • Detection of microRNAs and assays to monitor microRNA activities in vivo and in vitro / Marianthi Kiriakidou ... [et al.] -- High-throughput analysis of microRNA gene expression using sensitive probes / Mouldy Sioud and Øystein Røsok -- Modification of human U1 snRNA for inhibition of gene expression at the level of pre-mRNA / Peng Liu ... [et al.]. Identification of components of RNAi pathways using the tandem affinity purification method / Mikiko C. Siomi and Haruhiko Siomi -- Separation of Drosophila RNA silencing complexes by native gel electrophoresis / John W. Pham and Erik J. Sontheimer -- Preparation and analysis of drosha / Yoontae Lee and V. Narry Kim -- RNA interference in Caenorhabditis elegans / Nathaniel R. Dudley and Bob Goldstein -- Down-regulating gene expression by RNA interference in Trypanosoma brucei / Christine E. Clayton ... [et al.] -- Analysis of double-stranded RNA and small RNAs involved in RNA-mediated transcriptional gene silencing / M. Florian Mette ... [et al.] -- Strategies for the design of random siRNA libraries and the selection of anti-GFP siRNAs / Mouldy Sioud and Sébastien Wälchli -- Silencing gene expression with dicer-generated siRNA pools / Jason W. Myers and James E. Ferrell Jr. -- Inhibition of gene expression in vivo using multiplex siRNA / Sung-Suk Chae and Timothy Hla -- Gene silencing by a DNA vector based RNAi technology / Guangchao Sui and Yang Shi -- Plasmid-based RNA interference: construction of small-hairpin RNA expression vectors / Scott Q. Harper and Beverly L. Davidson -- SiRNA delivery in vivo / Mouldy Sioud -- Peptide-based strategy for siRNA delivery into mammalian cells / Federica Simeoni ... [et al.] -- Lentiviral vector delivery of siRNA and shRNA encoding genes into cultured and primary hematopoietic cells / Mingjie Li and John J. Rossi -- Exon-specific RNA interference: a tool to determine the functional relevance of proteins encoded by alternatively spliced mRNAs / Alicia M. Celotto, Joo-Won Lee, and Brenton R. Graveley -- Immunoprecipitation of microRNPs and directional cloning of microRNAs / Elisavet Maniataki, Maria Dels Angels De Planell Saguer, and Zissimos Mourelatos --
  • The key features of RNA silencing / Kuniaki Saito ... [et al.] -- Selected strategies for the delivery of siRNA in vitro and in vivo / Sandra D. Laufer ... [et al.] -- RNAi suppression and its application / Xiaoping Yi, Rui Lu -- Strategies to prevent siRNA-triggered cellular toxicity / Matthias Bauer -- RNAi in malignant brain tumors: relevance to molecular and translational research / Mitsutoshi Nakada ... [et al.] -- Silencing Huntington's disease gene with RNAi / Yu Zhang, Robert M. Friedlander -- Application of Dicer-substrate siRNA in pain research / Philippe Sarret ... [et al.] -- RNAi treatment of HIV-1 infection / Karin J. von Eije, Ben Berkhout -- Application of RNA interference to treat conditions associated with dysregulation of transient receptor potential vanilloid 1 channel / Vickram Ramkumar ... [et al.] -- Harnessing RNAi-based functional genomics to unravel the molecular complexity underlying skin pigment variation / Hsiang Ho ... [et al.] -- mRNA structure and its effects on posttranscriptional gene silencing / Stephen I. Rudnick, Veenu Aishwarya, Alan M. Gewirtz -- Antisense RNA-mediated regulation of the p53 tumor suppressor / Marianne Farnebo, Klas G. Wiman -- Antisense oligonucleotides: insights from preclinical studies and clinical trials / Doreen Kunze, Kai Kraemer, Susanne Fuessel -- What can the new hammerhead ribozyme structures teach us about design? / William G. Scott -- microRNA biogenesis and its impact on RNA interference / Stefanie Grund, Sven Diederichs -- MicroRNAs in epithelial antimicrobial immunity / Jun Liu ... [et al.] -- Emerging roles of long noncoding RNAs in gene expression and intracellular organization / Tetsuro Hirose -- Noncoding RNAs as therapeutic targets / Maciej Szymański, Jan Barciszewski -- Noncoding RNAs at H19/IGF2 locus: role in imprinting, gene expression, and associated pathologies / Nahalie Berteaux, Nathalie Spruyt, Eric Adriaenssens.
  • Print Material
  • 1. Isolation of a sequence-specific RNA binding protein, polypyrimidine tract binding protein using RNA affinity chromatography / Shalini Sharma -- 2. An affinity oligonucleotide displacement strategy to purify ribonucleoprotein complexes applied to human telomerase /Isabel Kurth, Gaël Cristofari, Joachim Lingner -- 3. RNA affinity tags for the rapid purification and investigation of RNAs and RNA-protein complexes / Scott C. Walker ... [et al.] -- 4. Assembly and glycerol gradient isolation of yeast spliceosomes containing transcribed or synthetic U6 SnRNA / Ken Dery, Shyue-Lee Yean, Ren-Jang Lin -- 5. Purification of ribonucleoproteins using peptide-elutable antibodies and other affinity techniques / Scott Stevens -- 6. CLIP: cross-linking and immunoprecipitation of in vivo RNA targets of RNA binding proteins / Kirk B Jensen, Robert B. Darnell -- 7. Quantitative analysis of protein-RNA interactions by gel mobility shift / Sean P. Ryder, Michael I. Recht, James R. Williamson -- 8. Monitoring assembly of ribonucleoprotein complexes by isothermal titration calorimetry / Michael I. Recht, Sean P. Ryder, James R. Williamson -- 9. Characterization of RNA-protein interactions by phosphorothioate footprinting and its applications to the ribosome / A. Ozlem Tastan Bishop, ... [et al.] -- 10. In vivo analysis of ribonucleoprotein complexes using nucleotide analog interference mapping / Lara Weinstein Szewczak -- 11. T7 RNA polymerase mediated incorporation of 8-N3AMP into RNA for studying protein-RNA interactions / Rajesh Gaur -- 12. A simple crosslinking method, CLAMP, to map the sites of RNA contacting domains within a protein / Hiren Banerjee, Ravinder Singh -- 13. Proteins specifically modified with a chemical nuclease as probes of RNA-protein interaction / Oliver A. Ken, Andrew M. MacMillan -- 14. RNA-protein crosslink mapping using TEV protease / Ian A. Turner, ... [et al.] -- 15 Structural analysis of protein-RNA interactions with mass spectrometry / Mamuka Kvaratskhelia, Stuart F.J. Le Grice -- 16. Analysing RNA-protein cross-linking sites in unlabeled ribonucleoprotein complexes by mass spectrometry / Henning Urlaub, Eva Kühn-Hölsken, Reinhard Lührmann -- 17. In vitro selection of random RNA fragments to identify protein binding sites within large RNAs / Ulrich Stelzl, Knud H. Nierhaus -- 18. Immunoprecipitation analysis to study RNA-protein interactions in xenopus oocytes / Naoto Mabuchi, Kaoru Masuyama, Mutsuhito Ohno -- 19. Mapping the regions of RNase P catalytic RNA that are potentially in close contact with its protein cofactor / Phong Trang, Fenyong Liu -- 20. Quantification of microRNAs, splicing isoforms, and homologous mRNAs with the invader assay / Peggy S. Eis, Mariano Garcia-Blanco -- 21. Analysis of RNA structure and RNA-protein interactions in mammalian cells by use of terminal transferase-dependent PCR / Hsiu-Hua Chen, Jeanne LeBon, Arthur D. Riggs -- 22. Duplex unwinding and RNP remodeling with RNA helicases / Eckhard Jankowsky, Margaret E. Fairman -- 23. Preparation of efficient splicing extracts from whole cells, nuclei, and cytoplasmic fractions / Naoyuki Kataoka, Gideon Dreyfuss -- 24. Designing and utilization of siRNAs targeting RNA-binding proteins / Dong-Ho Kim, Mark Behlke, John J. Rossi -- 25. The use of saccharomyces cerevisiae proteomic libraries to identify RNA-modifying proteins / Jane E. Jackman, Eric M. Phizicky.
  • RNAi design and application 2008
    Springer Protocols
  • RNAi technology 2011
    "RNA interference (RNAi) is a system within living cells that helps to control active genes and their activity level. Two types of small RNA molecules--microRNA (miRNA) and small interfering RNA (siRNA)--are central to RNA interference. The discovery of RNAi was preceded first by observations of transcriptional inhibition by antisense RNA expressed in transgenic plants and more directly by reports of unexpected outcomes in experiments performed by plant scientists in the U.S. and The Netherlands in the early 1990s. RNAi technology are used for large-scale screens that systematically shut down each gene in the cell, which can help identify the components necessary for a particular cellular process or an event such as cell division. Exploitation of the pathway is also a promising tool in biotechnology and medicine. This book reviews the selective and robust effect of RNAi on gene expression which makes it a valuable research tool, both in cell culture and in living organisms because synthetic dsRNA introduced into cells can induce suppression of specific genes of interest. This book will introduce new technology in the study of RNA interference in microorganisms, plants and animals."--Provided by publisher.
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  • The lung -- Head and neck -- Gastrointestinal tract -- Liver and biliary tract -- Pancreas -- Kidney -- The lower urinary tract and male genital system -- Female genital tract -- The breast -- The endocrine system -- The skin -- Bones, joints, and soft-tissue tumors -- Peripheral nerve and skeletal muscle -- Central nervous system -- The eye -- Final review and assessment.
  • Print Material
    Cell injury, cell death, and adaptations -- Acute and chronic inflammation -- Tissue repair : regeneration, healing, and fibrosis -- Hemodynamic disorders, thrombosis, and shock -- Diseases of the immune system -- Neoplasia / Thomas P. Stricker, Vinay Kumar -- Environmental and nutritional diseases -- General pathology of infectious diseases -- The blood vessels -- The heart / Frederick J. Schoen, Richard N. Mitchell -- The hematopoietic and lymphoid systems / Jon C. Aster -- The lung / Anirban Maitra, Vinay Kumar -- The kidney and its collecting system / Charles E. Alpers , Agnes B. Fogo -- The oral cavity and gastrointestinal tract -- The liver, gallbladder, and biliary tract -- The pancreas -- The male genital system -- The female genital system / Anthony Montag, Vinay Kumar -- The endocrine system / Anirban Maitra -- The musculoskeletal system -- The skin / Alexander J.F. Lazar -- The nervous system / Matthew P. Frosch.
  • This medical textbook's unbeatable author team helps you efficiently master the core concepts you need to know for your courses and USMLE exams. New interior design with a more modern look. Artwork revised and updated for a more modern look and more three-dimensional feel. Targeted Therapy boxes included - provides clinical information on appropriate therapy related to the disease under discussion. All photomicrographs and gross photos reviewed and improved to ensure excellent quality.
  • Print Material
  • Vital signs and patient monitoring techniques -- Respiratory procedures -- Cardiac procedures -- Vascular techniques and volume support -- Anesthetic and analgesic techniques -- Soft tissue procedures -- Gastrointestinal procedures -- Musculoskeletal procedures -- Genitourinary, obstetric, and gynecologic procedures -- Neurologic procedures -- Ophtalmologic, otolaryngologic, and dental procedures -- Special procedures.
  • Laparoscopic and robotic instrumentation for urologic reconstructive surgery in adults -- Instrumentation during pediatric robotic anastomoses and reconstruction -- Instrumentation during pediatric laparoscopic robotic anastomoses and reconstruction -- Adult laparoscopic partial nephrectomy for renal cell carcinoma -- Adult robotic-assisted partial nephrectomy for renal cell carcinoma -- Pediatric laparoscopic and robotic upper pole nephrectomy for nonfunctioning moieties -- Adult laparoscopic and robotic-assisted pyeloplasty for ureteropelvic junction obstruction -- Pediatric laparoscopic (infant, pre-pubertal, and teenager) pyeloplasty for ureteropelvic junction obstruction -- Pediatric robotic (infant, pre-pubertal, and teenager) pyeloplasty for ureteropelvic junction obstruction -- Laparoscopic ureteroureterostomy and correction of ureteral defects -- Robotic ureteroureterostomy and correction of ureteral defects -- Robotic radical cystectomy and use of intestinal segments for reconstruction in the adult patient -- Laparoscopic bladder augmentation and creation of continent-catheterizable stomas in the pediatric patient -- Laparoscopic ureteral reimplant surgery to correct reflux disease -- Robotic ureteral reimplant surgery to correct reflux disease -- Laparoscopoic and robotic orchiopexy for the impalpable undescended testicle -- Laparoscopic anastomoses and bladder neck reconstruction following radical prostatectomy -- Robotic anastomoses and bladder neck reconstruction following radical prostatectomy -- The role of NOTES and LESS in minimally invasive reconstructive urological surgery -- Laparoscopy and robotics in stress urinary incontinence and pelvic reconstructive surgery.
  • Robotic Cardiac Surgery is a comprehensive guide to robotic/totally endoscopic cardiac surgery. The book is intended to provide in-depth information regarding the history of robotic surgical systems, their components and principles. It emphasizes patient selection, perioperative management, anesthesia considerations and management, operative techniques and management, postoperative care and results. Extensive, detailed photographs and illustrations of different kinds of robotic surgery are also included. It provides cardiac surgeons, cardiac anesthesiologists, and perfusionists with a comprehensive review of current robotic cardiac surgeries and related knowledge.
  • Robotic Donor Nephrectomy - A Practical Guide is a user friendly manual aimed to give both novice and mature urologists a clear and comprehensive description of robot-assisted laparoscopic donor nephrectomy through a step-by-step approach. Novel techniques such as the Laparo-Endoscopic Single-Site (LESS) surgery are examined and the editors also look at the well established multi-ports techniques using the da Vinci Surgical system. Robotic Donor Nephrectomy - A Practical Guide will help young urologists gain better understanding of the techniques of robotic-assisted surgery, and support older urologists in 'crossing the border' towards laparoscopic surgery, particularly for delicate procedures such as the donor nephrectomy.
  • Part I: Robotic Technology and Instrumentation -- Robotic Technology and Ancillary Instruments in Renal Surgery -- Preoperative Preparation and Positioning for Robotic Renal Surgery -- Part II: Nephrectomy -- Robotic Simple and Radical Nephrectomy -- Robotic Donor Nephrectomy: Hand-Assisted Technique -- Robotic Nephrectomy for Complex Tumors -- Part III: Partial Nephrectomy -- Robotic Partial Nephrectomy: Basic Principles and Techniques -- Robot-Assisted Partial Nephrectomy: Complex Tumors and Evolving Techniques -- Near-Infrared Fluorescence Imaging in Robotic Partial Nephrectomy -- Part IV: Upper Urinary Tract Surgery -- Robotic Pyeloplasty -- Robotic Nephroureterectomy -- Robotic Ureteral Resection and Reconstruction for Urothelial Tumors and Benign Disease -- Part V: Pediatric Robotic Renal and Ureteral Surgery -- Upper Tract Obstruction -- Vesicoureteral Reflux and Ureteral Reimplantation -- Part VI: Advanced and Evolving Robotic Renal Techniques -- Retroperitoneal Robotic Kidney Surgery -- Single-Incision Robotic Renal and Ureteral Surgery.
  • Robotic surgery 2014
    1. Overview of robotic surgery -- 2. The de Vinci Surgical® systesm -- 3. Development of robotic systems -- 4. Robotic surgery in urology -- 5. Robotic gastrectomy for gastric cancer -- 6. Esophageal cancer surgery: robotic esophagectomy - 7. Lateral pelvic node dissection for advanced rectal cancer: current debates and use of the robotic approach -- 8. Cardiac surgery: overview -- 9. Robotically assisted totally endoscopic coronary artery bypass grafting -- 10. Robotic surgery for mitral valve disease -- 11. Robotic surgery in general thoracic surgery -- 12. Robot-assisted thyroidectomy.
  • Robotic Surgery of the Bladder is a dedicated resource to understanding and mastering the concepts and practical aspects of robotic bladder surgery. The volume provides an introduction to urologists interested in initiating robotic radical cystectomy by providing them background, concepts, steps, and tools and tricks to introduce robotic radical cystectomy into their clinical practice, all in a safe, stepwise, and organized manner. For the more experienced robotic surgeon, the text serves as a resource for more advanced applications and techniques. The volume is also accompanied by many still images and a DVD of video clips. Written by experts in the field, Robotic Surgery of the Bladder is a comprehensive resource that maintains the time-tested oncologic principles of bladder cancer surgery, while introducing the advantages that exist with robotic-assisted approaches.
  • Robotic Surgery of the Head and Neck is the first comprehensive guide for otolaryngologists who wish to perform robotic head and neck surgery. Edited by leaders in the field, this book focuses on how improved access, visualization, and flexibility of the technology have greatly expanded the capabilities of the head and neck surgeon to treat diseases transorally or through small incisions in the skin. Starting with an overview of minimally invasive surgery in the head and neck, and moving to discussions of anatomic considerations for these procedures and the future applications of robotic surgery for otolaryngologists, Robotic Surgery of the Head and Neck explores the exciting progress of robotic technologies, bringing physicians closer to achieving the benefits of traditional surgery with the least amount of disruption to the patient.
  • This book describes the current applications of the robotic system in general surgery, focusing on the technical aspects of the procedures most commonly performed by this means. It provides a comprehensive overview of the state of the art in robotic surgery and presents the most recently available evidence as documented in the literature. The opening chapters review robotic platforms, discuss the general advantages, limitations, and strategies of robotic surgery, and identify challenges and critical elements when setting up a robotic program. The full range of applications of the robotic system is then covered, encompassing thoracic, esophageal, gastric, hepatobiliopancreatic, splenic, colorectal, endocrine, and transplantation surgery. Detailed attention is also paid to innovative applications and future trends in the robotic platform, with inclusion of a special chapter on fluorescence imaging during robotic procedures. The book closes by considering aspects related to credentialing and privileging, such as mentoring, proctoring, and teaching modules for residents and fellows. Against the background of increasing acceptance of the robotic surgery system across the globe, this book will be invaluable for all general surgeons. There is no doubt that within general surgery the system will continue to flourish on account of its undoubted technical advantages, which minimize most of the intrinsic shortcomings of laparoscopy.
  • Pt. 1. Introduction to robotic surgery -- Pt. 2. Robotic surgery of the prostate -- Pt. 3. Kidney and adrenals -- Pt. 4. Bladder cancer -- Pt. 5. Pediatric urology -- Pt. 6. Robotic microsurgery -- Pt. 7. Allied health -- Pt. 8. Executive.
  • Part I: Kidneys -- Surgical Anatomy of Kidneys and Adrenals -- Robotic Kidney Surgery -- Partial Resection of the Kidney for Renal Cancer -- Robotic Nephroureterectomy -- Robotic Pyeloplasty -- Part II: Adrenals -- Robotic Adrenal Surgery -- Part III: Pelvis -- Surgical Anatomy of Pelvic Lymph Nodes -- Robotic-Assisted Pelvic Lymph Node Dissection -- Pelvic Lymphadenectomy for Localised Prostate Cancer and Robot-Assisted Radical Prostatectomy -- Part IV: Bladder -- Surgical Anatomy of the Bladder -- Robotic-Assisted Radical Cystectomy for Bladder Cancer in the Female -- Male Robot-Assisted Radical Cystectomy -- Robotic-Assisted Intracorporeal Urinary Diversion -- Technique of Extracorporeal Urinary Diversion -- Robot-Assisted Laparoscopic Ureteral Reimplantation -- Part V: Prostate -- Surgical Anatomy of the Prostate for Radical Prostatectomy -- Anatomical Aspects of the Neurovascular Bundle in Prostate Surgery -- Part VI: Benign Disease -- Robotic Adenomectomy -- Part VII: Radical Prostatectomy -- Trans- and Extraperitoneal Approach for Robotic-Assisted Radical Prostatectomy -- Radical Prostatectomy: Anterior Approach -- Robotic Prostatectomy: The Posterior Approach -- Bladder Neck Dissection During Robotic-Assisted Laparoscopic Radical Prostatectomy -- Techniques of Nerve Sparing in Robot-Assisted Radical Prostatectomy -- Antegrade Robot-Assisted Radical Prostatectomy: Factors Impacting Potency Preservation -- Allogenic Nerve Interposition During Non-Nerve-Sparing Robot-Assisted Radical Prostatectomy -- The Apical Dissection -- Posterior Reconstruction of the Rhabdosphincter -- The Urethrovesical Anastomosis -- Robotic-Assisted Laparoscopic Radical Salvage Prostatectomy -- Outcome Measures After Robot-Assisted Radical Prostatectomy -- Urinary Incontinence After Robotic-Assisted Laparoscopic Radical Prostatectomy -- Part VIII: Reconstructive Urology -- Paediatric Pelvic Exenteration -- Robot-Assisted Laparoscopy for Genital Organ Prolapse -- Robot-Assisted Laparoscopic Repair of Supratrigonal Vesicovaginal Fistulae with Peritoneal Flap Inlay -- Robotic Surgical Training: Imparting Necessary Skills to Future Urologic Surgeons.
  • Robotics in General Surgery provides a comprehensive review of the current applications of the robotic platform in all the general surgery subspecialties. Additionally, for each subspecialty it serves as a procedure-oriented instruction manual in terms of technical details of procedures, including fundamentals of robot positioning and trocar placement, step-by-step description of procedures, comprehensive discussions of advantages, limitations, indications, and relative contraindications of using the robotic approach. The text also discusses the challenges and steps to overcoming these challenges in transitioning from a minimally invasive to a robotic practice/surgeon. Lastly, this volume addresses emerging technology in robotics and the impact that the robotics platform will have on not only practice of surgery, but also in the education of surgeons at all levels. Written by experts in the field of robotic surgery, Robotics in General Surgery is a valuable resource for general surgeons of all levels including residents, fellows and surgeons already in practice.
  • The History of Robotic Surgery -- Robotic Instrumentation and Operating Room Setup -- Port Placement in Robotic Urologic Surgery -- Achieving Efficiency in the Operating Room: Step by Step -- Laparoscopy vs. Robotics: Ergonomics -- Does It Matter? -- Anesthetic Considerations for Robotic Urologic Surgery -- The Development of a Robotic Urology Program in the UK -- Robotic Urologic Surgery: How to Make an Effective Robotic Program -- Witnessing the Transition of Open to Robotic Surgery -- Patient-Side Surgeons: The Unsung Heroes of Robotic Surgery -- Training in Robotic Urologic Surgery -- Animal Laboratory Training: Current Status and How Essential Is It? -- Training of Operating Room Technician and Nurses in Robotic Surgery -- Impact of Virtual Reality Simulators in Training of Robotic Surgery -- Training, Credentialing, and Hospital Privileging for Robotic Urological Surgery -- Research in Urologic Oncology in an Era of Minimally Invasive Surgery -- Databases and Data Management for Robotic Surgery -- The Role of Scientific Journals in Disseminating New Technology -- Predicting Robotic Utilization in Urologic Disease: An Epidemiology-Based Model -- Development of the Vattikuti Institute Prostatectomy: Historical Perspective and Technical Nuances -- Transferring Knowledge of Anatomical Dissection from the Laboratory to the Patient: An Australian Perspective -- Robot-Assisted Radical Prostatectomy: A Prostate Surgeon's Perspective -- Cautery-Free Technique of Robot-Assisted Radical Prostatectomy: Impact on Nerve Preservation and Long-Term Outcome on Recovery of Sexual Function -- Current Concepts in Cavernosal Neural Anatomy and Imaging and Their Implications for Nerve-Sparing Radical Prostatectomy -- Robot-Assisted Radical Prostatectomy for Large Glands and Median Lobe -- Extraperitoneal Robot-Assisted Radical Prostatectomy: Simulating the Gold Standard -- The Retrograde Extraperitoneal Approach: Robotic Retrograde Extraperitoneal Laparoscopic Prostatectomy (RRELP). Technical Modifications for Robotic Prostatectomy -- Robotic Radical Prostatectomy: Cancer Control and Implications of Margin Positivity -- Techniques to Improve Urinary Continence Following Robot-Assisted Radical Prostatectomy -- Penile Rehabilitation After Robotic Radical Prostatectomy: The Best Strategy -- Laparoscopy or Robotic Radical Prostatectomy: Pros and Cons -- Complications of Robotic Prostatectomy -- Robotic Urologic Surgery: Robotic-Assisted Adrenalectomy -- Robot-Assisted Laparoscopic Radical Nephrectomy and Nephroureterectomy -- Robot-Assisted Partial Nephrectomy -- Robotic Urologic Surgery: Robot-Assisted Partial Nephrectomy -- Robotic Donor Nephrectomy: Technique and Outcomes -- An European Perspective -- Robot-Assisted Laparoscopic Pyeloplasty -- Robotic Surgery for Urolithiasis -- Ureteral Reconstruction Utilizing Robotic-Assisted Techniques -- Robotic or Laparoscopic Renal Surgery: Pros and Cons -- Robot-Assisted Radical Cystectomy in Male: Technique of Spaces -- Robotic-Assisted Laparoscopic Anterior Pelvic Exenteration for Bladder Cancer in the Female -- Robotic-Assisted Laparoscopic Extended Pelvic Lymph Node Dissection for Bladder Cancer -- Robot-Assisted Intracorporeal Ileal Conduit -- Robotic Urinary Diversion: Technique, Current Status, and Outcomes -- Robotic Bladder Surgery Complications: Prevention and Management -- Robotic Surgery for Ureteral Anomalies in Children -- Robotic Surgery of the Kidney in Children -- Robotic Bladder Surgery in Children -- Robotic Surgery in Urogynecology -- Robotic Repair of Vesico-vaginal Fistula -- Robotic Surgery in Male Infertility (Robotic-Assisted Microsurgery) -- Treater to Target: Experiences of a Prostate Cancer Participant -- My Prostate Cancer -- Telementoring and Telesurgery in Urology -- Robotic Systems: Past, Present, and Future.
  • This new reference is the first of its kind devoted to the exploding area of robotic-assisted urologic surgery. It covers setting up robotics and instrumentation, as well as adapting laparoscopic equipment to this exciting new technology. It also guides you through a full range of robotic procedures including prostatectomy, which is experiencing significant success and patient satisfaction by using robotic technology, as well as nephrectomy, adrenalectomy, vasovasostomy, and pediatric procedures. Full color illustrations help familiarize you with the latest surgical techniques and instrumentation. Cuts patient recovery time in half with coverage of robotic assisted prostatectomy. Covers all urologic procedures that are adaptable to robotic technology with chapters on cystectomy, nephrectomy, prostatectomy, vasovasostomy, and adrenalectomy. Offers full color images of procedures to enhance surgical concepts.
  • "The present book initiates the concept of robust response surface designs, along with the relevant regression and positive data analysis techniques. Response surface methodology (RSM), well-known in literature, is widely used in every field of science and technology such as Biology, Natural (Physical/Chemical), Environmental, Medical, Agricultural, Quality engineering etc. RSM is the most popular experimental data generating, modeling and optimization technique in every field of science. It is a particular case of robust response surface methodology (RRSM). RSM has many limitations, and RRSM aims to overcome many of such limitations. Thus, RRSM will be much better than RSM. It is intended for anyone who knows basic concepts of experimental designs and regression analysis. This is the first unique book on RRSM. Every chapter is unique regarding its contents, presentation and organization. Problems on robust response surface designs such as rotatability, slope-rotatability, weak rotatability, optimality, and along with the method of estimation of model parameters, positive data analysis techniques are considered in this book. Some real examples on lifetime responses, resistivity, replicated measures, medical, demography, hydrogeology data etc., are analysed. Some examples (considered in this book) on design of experiments do not satisfy the classical assumptions of response surface methodology."-- Provided by publisher.
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    "In the first half of the twentieth century, reformers attempted to use the knowledge and practices of the laboratory sciences to transform medicine radically. Change was to be effected through medicine's major institutions: hospitals were to be turned into businesses and united to university-based medical schools. American ideas and money were major movers of these reforms. The Rockefeller Foundation supported these changes worldwide. Reform, however, was not always welcomed. In Britain many old hospitals and medical schools stood by their educational and healing traditions. Further, American ideals were often seen as part of a larger transatlantic threat to British ways of life. In Edinburgh, targeted by reformers as an important centre for training doctors for the Empire, reform was resisted on the grounds that the city had sound methods of education and patient care matured over time. This resistance was part of an anxiety about a wholesale invasion by American culture that was seen to be destroying Edinburgh's cherished values and traditions. These latter in turn were seen to stem from a distinct Scottish way of life. This book examines this culture clash through attempts to introduce the laboratory sciences, particularly biochemistry, into the Edinburgh medical world of the 1920s."--Jacket.
  • Biomechanics of fixation and fractures / Allan F. Tencer -- Classification of fractures / Douglas R. Dirschl and Lisa K. Cannada-- Management of the multiply injured patient / Hans-Christoph Pape and Peter Giannoudis -- The epidemiology of fractures. pt. 1. Overview of epidemiology / Charles M. Court-Brown and Benjamin C. Caesar -- pt. 2. Experience in the United States / Kenneth J. Koval and Michael Cooley -- Nonoperative fracture treatment / John F. Connolly -- Principles of internal fixation / Christian Krettek and Thomas Gösling -- Principles of external fixation / J. Tracy Watson -- Bone and joint healing / Joseph A. Buckwalter, Thomas A. Einhorn and J.L. Marsh -- Bone grafting and enhancement of fracture repair / Sanjeev Kakar, Eleftherios Tsiridis, and Thomas A. Einhorn -- Outcome studies in trauma / Mohit Bhandari -- Imaging considerations in orthopaedic trauma / Andrew H. Schmidt and Kerry M. Kallas -- Initial management of open fractures / Steven A. Olson and Mark C. Willis -- Acute compartment syndrome / Margaret M. McQueen -- Penetrating trauma / Edward A. Perez -- War wounds, limb salvage, and traumatic amputations / Paul J. Dougherty -- Bone and soft tissue reconstruction / Lior Heller and L. Scott Levin -- Systemic complications / David C. Templeman and William A. Marinelli -- Local complications / Kirti D. Moholkar and Bruce H. Ziran -- Osteoporotic fractures / Magnus K. Karlsson, Karl Obrant and Per Olof Josefsson -- Pathologic fractures / Kristy L. Weber -- Stress fractures / David C. Teague -- Periprosthetic fractures. pt. 1. Periprosthetic fractures of the elbow and shoulder / Robert H. Cofield ... [et al.] -- pt. 2. Periprosthetic fractures about total hip and total knee replacements / Jay D. Mabrey -- Computer-aided orthopaedic surgery in skeletal trauma / Meir Liebergall, Rami Mosheiff, and Leo Joskowicz -- Fractures and dislocations of the hand / Mark H. Henry -- Fractures and dislocations of the carpus / Christian Gaebler -- Fractures of the distal radius and ulna / David S. Ruch -- Fractures of the shafts of the radius and ulna / Ralph Hertel and Dominique A. Rothenfluh -- Fractures and dislocations of the elbow / David Ring -- Fractures of the distal humerus / C. Michael Robinson -- Fractures of the shaft of the humerus / Michael D. McKee -- Fractures of the proximal humerus / Jon J. P. Warner, John G. Costouros and Christian Gerber -- Fractures of the clavicle / Mark D. Lazarus and Carl Seon -- Fractures of the scapula / Kenneth P. Butters -- Subluxations and dislocations about the glenohumeral joint / Young W. Kwon and Joseph D. Zuckerman -- Acromioclavicular joint injuries / Leesa M. Galatz and Gerald R. Williams, Jr. -- Injuries to the sternoclavicular joint / Gregory J. Gilot, Michael A. Wirth and Charles A. Rockwood, Jr. -- Principles of spine trauma care / Sohail K. Mirza, Carlo Bellabarba and Jens R. Chapman -- Injuries of the craniocervical junction / Carlo Bellabarba, Sohail D. Mirza and Jens R. Chapman -- Fractures and dislocations of the lower cervical spine / Christopher M. Bono -- Fractures and dislocations of the thoracolumbar spine / Robert K. Eastlack and Christopher M. Bono -- Fractures of the pelvic ring / Adam J. Starr and A. Steven Malekzadeh -- Fractures of the acetabulum / Mark C. Reilly -- Hip dislocations and fractures of the femoral head / Paul Tornetta III -- Fractures of the neck of the femur / Ross K. Leighton -- Intertrochanteric fractures / Kenneth J. Koval and Robert V. Cantu -- Subtrochanteric fractures / Kwok-sui Leung -- Fractures of the shaft of the femur / Sean E. Nork -- Fractures of the distal femur / Peter J. OBrien ... [et al.] -- Fractures of the patella and injuries to the extensor mechanism / Robert M. Harris -- Fractures of the proximal tibia / Kenneth A. Egol and Kenneth J. Koval -- Dislocations and fracture-dislocations of the knee / Robert C. Schenck, Jr., James P. Stannard, and Daniel C. Wascher -- Fractures of the tibia and fibula / Charles M. Court-Brown -- Ankle fractures / J.L. Marsh and Charles L. Saltzman -- Fractures of the talus / David W. Sanders -- Fractures of the calcaneus / Roy W. Sanders and Michael P. Clare -- Fractures and dislocations of the midfoot and forefoot / John S. Early.
  • "The 8th edition of Rockwood and Green's Fractures in Adults continues with the changes that were instituted in the 7th edition. In this edition there are two more chapters and 61 new authors drawn from three continents and eleven different countries... In addition, many of the new authors represent the next generation of orthopaedic trauma surgeons who will be determining the direction of trauma management over the next two or three decades"-- Provided by publisher.
  • Incidence of fractures in children / Kaye E. Wilkins and Alaric J. Aroojis -- The biologic aspects of children's fractures / Cory J. Xian and Bruce K. Foster -- Pain relief and related concerns in children's fractures / Joseph R. Furman -- Management of the multiply injured child / Robert M. Kay and Vernon T. Tolo -- Physeal injuries and growth disturbances / Karl E. Rathjen and John G. Birch -- Pathologic fractures associated with tumors and unique conditions of the musculoskeletal system / John P. Dormans and John M. Flynn -- Child abuse / Robert M. Campbell, Jr. and Timothy Schrader -- Fractures and dislocations of the hand and carpus in children / Scott H. Kozin and Peter M. Waters -- Fractures of the distal radius and ulna / Peter M. Waters and Alexander D. Mih -- Injuries to the shafts of the radius and ulna / Charles T. Mehlman and Eric J. Wall -- Fractures of the proximal radius and ulna / Robert E. Eilert and Mark A. Erickson -- Monteggia fracture-dislocation in children / José F. de la Garza -- The elbow region: general concepts in the pediatric patient / James H. Beaty and James R. Kasser -- Supracondylar fractures of the distal humerus / James R. Kasser and James H. Beaty -- The elbow: physeal fractures, apophyseal injuries of the distal humerus, osteonecrosis of the trochlea, and t-condylar fractures / James H. Beaty and James R. Kasser -- Dislocations of the elbow / Anthony A. Stans and Stephen D. Heinrich -- Proximal humerus, scapula, and clavicle / John F. Sarwark, Erik C. King, and Scott J. Luhmann -- Cervical spine injuries in children / William C. Warner, Jr. and Daniel J. Hedequist -- Thoracolumbar spine fractures / Peter O. Newton -- Fractures of the pelvis / Roger F. Widmann -- Fractures and traumatic dislocations of the hip in children / R. Dale Blasier and Laurie O. Hughes -- Femoral shaft fractures / James R. Kasser and James H. Beaty -- Extra-articular injuries of the knee / David L. Skaggs -- Intra-articular injuries of the knee / Mininder S. Kocher -- Fractures of the shaft of the tibia and fibula / Stephen D. Heinrich and James F. Mooney III -- Distal tibial and fibular fractures / R. Jay Cummings -- Fractures and dislocations of the foot / James G. Jarvis and Paul J. Moroz.
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    Epidemiology of fractures in children -- The biologic aspects of children's fractures -- Pain relief and related concerns in children's fractures -- Management of the multiply injured child -- Physeal injuries and growth disturbances -- Pathologic fractures associated with tumors and unique conditions of the musculoskeletal system -- The orthopaedic recognition of child maltreatment -- Fractures and dislocations of the hand and carpus in children -- Fractures of the distal radius and ulna -- Injuries to the shafts of the radius and ulna -- Fractures of the proximal radius and ulna -- Monteggia fracture-dislocation in children -- The elbow region: general concepts in the pediatric patient -- Supracondylar fractures of the distal humerus -- The elbow: physeal fractures, apophyseal injuries of the distal humerus, osteonecrosis of the trochlea, and T-condylar fractures -- Dislocation of the elbow -- Proximal humerus, scapula, and clavicle -- Cervical spine injuries in children -- Thoracolumbar spine fractures -- Fractures of the pelvis -- Fractures and traumatic dislocations of the hip in children -- Femoral shaft fractures -- Extra-articular injuries of the knee -- Intra-articular injuries of the knee -- Fractures of the shaft of the tibia and fibula -- Distal tibial and fibular fractures -- Fractures and dislocations of the foot.
  • "For the gold-standard resource on pediatric fractures, reach for Rockwood and Wilkins' Fractures in Children. Written by leading orthopaedic surgeons from around the world, the revised and expanded 8th edition of this classic bestselling text presents complete, up-to-date coverage of all types of children's fractures. A must-read for pediatric orthopedic surgeons and orthopedic residents. Features: NEW expanded coverage of pain medicine and casting; NEW 6 new authors from around the world; NEW time-saving outline template for easy quick-reference. Step-by-step instructions and expert guidance on numerous operative and management techniques. Author's Preferred Technique section includes algorithms explaining why the author chose that procedure. Pearls and Pitfalls and preventive measures listed for all procedures. NEW 13 full length procedural videos. Casting, remodeling and unique features of children's fractures. Now with the print edition, enjoy the bundled interactive eBook edition, offering tablet, smartphone, or online access to: Complete content with enhanced navigation, A powerful search that pulls results from content in the book, your notes, and even the web, Cross-linked pages, references, and more for easy navigation, Highlighting tool for easier reference of key content throughout the text, Ability to take and share notes with friends and colleagues, Quick reference tabbing to save your favorite content for future use, 13 full length procedural videos"--Provided by publisher.
  • This book introduces transplantation in rodents as useful tools used in studying transplant immunobiology. Several solid organs (kidney, heart, liver) transplant models in rodents are described in this book. It can help surgical quality and save surgical time. The first part of the book provides a review of rodent transplant tolerance induction, the role of gender and body-weight in rodent transplantation, surgical instruments and organ preservation solutions. In the second part of the book, various organ-transplantation techniques in rodents are discussed in individual chapters. This book presents uniform surgical procedures in mouse and rats, which produce comparable data, efficiently enhancing the translational research from bench to non-human primates and beyond. It will be of great value to transplant researchers, research fellows and clinicians in many surgical specialties. Editor Weihua Gong is an Associate Professor at the Department of Surgery, the 2nd Affiliated Hospital of Zhejiang University, China.
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    Innate immunity -- Specific acquired immunity -- Antibodies -- Membrane receptors for antigen -- The primary interaction with antigen -- Immunological methods and applications -- The anatomy of the immune response -- Lymphocyte activation -- The production of effectors -- Control mechanisms -- Ontogeny and phylogeny -- Adversarial strategies during infection -- Vaccines -- Immunodeficiency -- Hypersensitivity -- Transplantation -- Tumor immunology -- Autoimmune diseases.
  • Part I: Evolution and Development of Missions -- Medical Missions: A Short History from There to Here -- The Evolution of Surgical and Humanitarian Missions -- The Global Burden of Surgical Need -- Comparative Economics of Anesthesia Care and the Global Anesthesia Workforce -- Planning a Mission, Fundraising, and Building a Team: The Kybele Experience -- Organizing and Developing Universal Anesthetic Equipment -- Materials Management -- What do Patients and Communities Expect of a Medical Mission? -- Anesthesia in Resource-Poor Settings: The Mďecins sans Frontir̈es Experience -- Quality Care: Maintaining Safety Through Minimum Standards -- Legal and Ethical Issues in Global Health: A Trip through the Vagaries of Truth and Culture -- Part II: Specific Case Related Implementation -- Strategies for Patient Assessment and Scheduling -- Postoperative Follow-up and Quality Maintenance -- Women?s Rights and the Right to Pain Relief in Surgery and Labor -- Saving Sight In Developing Countries -- Cardiac Anaesthesthesia in Low Resource Settings -- Anesthesia Considerations for Facial Deformity Repair in Lesser Developed Countries -- Implementing a Regional Anesthesiology Service in a Low Resource Setting -- The Management of Pain in Less Developed Countries -- Living the Mission in Serbia and Other Less Affluent Worlds -- Anesthetic Management During the Lebanese Civil War -- Trauma, War, And Managing Vascular And Orthopedic Injuries -- Emergency Deployment in Disaster Areas -- Part III: Education at Home and Abroad -- Missions as a Part of Medical Education and the Residency Curriculum -- Global Health Programs in Academic Centers.- Closing the Professional Gap in Europe Through Education -- The Role of the Visiting Anesthesiologist in In-Country Education -- Letters (Lessons) from Around the World (Vignettes) -- The Future of Anesthesiology and Global Health in a Connected World.
  • A short introduction to disease emergence / Nicholas Johnson -- Patterns of foot-and-mouth disease virus distribution in Africa / Miriam B. Casey [and eleven others] -- Paroviruses of carnivores / Andrew B. Allison and Colin R. Parrish -- Rabies / Conrad Freuling [and four others] -- Lassa fever / Elisabeth Fichet-Calvet -- Henipaviruses / Glenn A. Marsh and Lin-Fa Wang -- The role of birds in the spread of West Nile virus / Paul Gale and Nicholas Johnson -- Rift Valley fever virus / Janusz T. Paweska and Petrus Jansen van Vuren -- From simian to human immunodeficiency viruses (SIV to HIV) / Denis M. Tebit and Eric J. Arts -- Hantavirus emergence in rodents, insectivores and bats / Mathias Schlegel [and four others] -- Nipah virus / David T.S. Hayman and Nicholas Johnson -- Synthesis / Philip R. Wakeley, Sarah North and Nicholas Johnson.
  • Mechanisms of apoptosis during reovirus infection / P. Clarke ... [et al.] -- Poliovirus, pathogenesis of poliomyelitis, and apoptosis / B. Blondel ... [et al.] -- Neuronal cell death in alphavirus encephalomyelitis / D. E. Griffin -- HSV-induced apoptosis in herpes encephalitis / L. Aurelian -- The role of apoptosis in defense against baculovirus infection in insects / R. J. Clem -- The role of host cell death in Salmonella infections / D. G. Guiney -- Role of macrophage apoptosis in the pathogenesis of Yersinia / Y. Zhang, J. B. Bliska -- Entamoeba histolytica activates host cell caspases during contact-dependent cell killing / D. R. Boettner, W. A. Petri -- Interactions between malaria and mosquitoes : the role of apoptosis in parasite establishment and vector response to infection / H. Hurd, V. Carter, A. Nacer -- Apoptosis and its modulation during infection with Toxoplasma gondii : molecular mechanisms and role in pathogenesis / C. G. K. Luder, U. Gross -- Modulation of the immune response in the nervous system by rabies virus / M. Lafon -- Apoptotic cells at the crossroads of tolerance and immunity / M. Skoberne ... [et al.].
  • Role of Capsaicin in Cancer Prevention -- Role of Death Receptors Belonging to the TNF Family in Capsaicin-Induced Apoptosis of Tumor Cells -- Role of Capsaicin in Prostate Cancer -- Capsaicin and the Urinary Bladder -- Inhibition of Pancreatitis and Carcinogenesis by Capsaicin -- Cytochrome P450-Dependent Modification of Capsaicinoids: Pharmacological Inactivation and Bioactivation Mechanisms -- The Cancer-Suppressing and -Promoting Actions of Capsaicin -- Oxidative Stress by Capsaicin in Cancer.
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    v. 1. Hypertension.
  • This new volume in the series Emerging Infectious Diseases of the 21st Century is a novel book on the role of microbes in the pathogenesis of common and disabling non-infectious diseases. New insights have emerged over the past several years suggesting that our commensal microflora of the gut is extremely important in regulating physiological and immune functions of the body. Covered are the perturbations of the normal composition of our endogenous microbiota, influenced by diet and genetic predispositions, as well as the mechanisms to produce common disorders such as obesity, diabetes, irritable bowel syndrome, colon cancer, and atherosclerotic vascular diseases. Also explored is the evidence suggesting that predisposition to increasingly common afflictions such as asthma and multiple sclerosis is influenced, in combination with our genetic composition, by early life exposure to environmental microbes and the time of onset of common viral infections. Chapters provide the most recent information on these disorders with regards to epidemiology, current concepts on pathogenesis and mechanisms of their biology, recent research and data on the role of microbes, analysis of their validity, and conclusive remarks and areas for future research. The Role of Microbes in Common Non-Infectious Diseases is an excellent resource for both physicians and investigators from a broad range of disciplines that will help to stimulate new concepts of disease pathogenesis, and lead to the unraveling of their mechanisms of diseases and to novel treatments. About the Author Ignatius [Bill] Fong is a Professor of Medicine at the University of Toronto and he is an author/ editor of 8 previously published books on Infectious Diseases. His research interests include topics in clinical infectious disease, HIV infection, and microbial-induced or -associated atherosclerosis.
  • Section 1. Introduction -- section 2. Oxidative stress and genetic polymorphism -- section 3. Oxidative stress in transmissible chronic diseases -- section 4. Oxidative stress in metabolic diseases -- section 5. Oxidative stress in autoimmune and neurodegenerative diseases -- section 6. Oxidative stress in cancer and cachexia.
  • It is now well known that proteases are found everywhere, in viruses and bacteria as well as in all human, animal and plant cells, and play a role in a variety of biological functions ranging from digestion, fertilization, development to senescence and death. Under physiological conditions the ability of proteases is regulated by endogenous inhibitors. However, when the activity of proteases is not regulated appropriately, disease processes can result, as seen in Alzheimer's disease, cancer metastasis and tumor progression, inflammation and atherosclerosis. Thus it is evident that there is an absolute need for a tighter control of proteolytic activities in different cells and tissues. Aimed at graduate students and researchers with an interest in cellular proteolytic events, Role of Proteases in Cellular Dysfunctions is the second book on Proteases in this series. The book consists of three parts in specified topics based on current literatures for a better understanding for the readers with respect to their subject-wise interests. The first section of this book covers a brief idea about the neuronal disorders and the involvement of proteases such as calpains, caspases and matrix metalloproteases (MMPs). The second section covers the deadly disease cancer and its relation to ubiquitin-proteosomal system, MMPs and serine proteases. The last section is about the role of proteases such as calpains, MMPs and serine protease as well as urokinase type plasminogen activator receptor (uPAR) in causing cardiovascular defects.
  • To examine how purchasers and payers interact with the various components of the clinical research enterprise and to understand their perspective on what vision of the enterprise should be.
  • Interdiction of sphingolipid metabolism to improve standard cancer therapies -- Diverse functions of ceramide in cancer cell death and proliferation -- Cermaide glycosylation catalyzed by glucosylceramide synthase and cancer drug resistance -- Use of acid sphingomyelinase for cancer therapy -- Hypoxia therapeuric resistance and sphingosine 1-phosphate -- Therapeutic potential of targeting SK1 in human cancers -- Sphinogosine kinase 1 in cancer -- Natural products as platforms for the design of sphingolipid-related anticancer agents.
  • This book is designed for advanced students and researchers in cell biology, biochemistry, molecular biology, medicine in general, and cancer in particular. It provides the latest data on the transcriptome of the mammary gland in order to establish the molecular and cellular biology of differentiation leading to cancer prevention. The authors have based their work on the epidemiological evidence that early first full term pregnancy is a protective factor in humans against breast cancer and using this knowledge have developed in vivo and in vitro experimental systems that have demonstrated mechanistically how the differentiation takes place. The transcriptoma analysis of the female breast shows that an early first full term pregnancy reprograms the organ by imprinting a genomic signature that differs according to reproductive history. This reprogramming takes place at the chromatin level by changing the transcriptional process. The modification of the transcriptional control is due to the expression of non-coding RNA sequences and post-transcriptional control driven by the spliceosome. The plasticity of the genome of the human breast makes possible this reprogramming that is not only induced by the physiological process of pregnancy but by the use of hormones mimicking pregnancy. The role of stem cells and their reprogramming during differentiation are presented as a new paradigm in breast cancer prevention.
  • Root genomics 2011
    With the predicted increase of the human population and the subsequent need for larger food supplies, root health in crop plants could play a major role in providing sustainable highly productive crops that can cope with global climate changes. While the essentiality of roots and their relation to plant performance is broadly recognized, less is known about their role in plant growth and development. "Root Genomics" examines how various new genomic technologies are rapidly being applied to the study of roots, including high-throughput sequencing and genotyping, Tilling, transcription.
  • V. 1 -- Introduction -- Gross techniques in surgical pathology -- Special techniques in surgical pathology -- Skin -- dermatoses -- Skin -- tumors and tumorlike conditions -- Oral cavity and oropharynx -- Mandible and maxilla -- Respiratory tract -- nasal cavity, paranasal sinuses, and nasopharynx -- Respiratory tract -- larynx and trachea -- Respiratory tract -- lung and pleura -- Mediastinum -- Thyroid gland (with giovanni tallini) -- Parathyroid glands -- Gastrointestinal tract -- esophagus -- Gastrointestinal tract -- stomach -- Gastrointestinal tract -- small bowel -- Gastrointestinal tract -- appendix -- Gastrointestinal tract -- large bowel -- Gastrointestional tract -- anus -- Major and minor salivary glands -- Liver -- non-neoplastic diseases -- Liver -- tumors and tumorlike conditions -- Gallbladder and extrahepatic bile ducts -- Pancreas and ampullary region -- Adrenal gland and other paraganglia -- Urinary tract -- kidney, renal pelvis, and ureter: non-neoplastic diseases -- Urinary tract -- kidney, renal pelvis, and ureter: pediatric tumors and tumorlike conditions/adult tumors and tumorlike conditions -- Urinary tract -- bladder -- Male reproductive system -- prostate and seminal vesicles -- Male reproductive system -- testis -- Male reproductive system -- testicular adnexa -- Male reproductive system -- penis and scrotum -- V. 2 -- Female reproductive system -- vulva -- Female reproductive system -- vagina -- Female reproductive system -- uterus: cervix -- Female reproductive system -- uterus: corpus -- Female reproductive system -- fallopian tube -- Female reproductive system -- ovary -- Female reproductive system -- placenta -- Breast -- Lymph nodes -- Spleen -- Bone marrow -- Bone and joints -- Soft tissues -- Peritoneum, retroperitoneum, and related structures -- Cardiovascular system -- heart -- Cardiovascular system -- arteries -- Cardiovascular system -- veins -- Cardiovascular system -- lymph vessels -- Central nervous system -- Pituitary gland -- Eye and ocular adnexa -- Ear.
  • "This best-selling emergency department reference is now in its thoroughly updated Fifth Edition. The foremost authorities provide practical information on over 600 clinical problems in a fast-access two-page outline format that's perfect for on-the-spot consultation during care in the emergency department.Coverage of each disorder includes clinical presentation, pre-hospital, diagnosis, treatment, disposition, and ICD-9 coding. Icons enable practitioners to quickly spot the information they need. This edition provides up-to-date information on topics such as emerging infections, new protocols, and new treatments"--Provided by publisher.
  • Ch. 1. Anatomy and physiologic morphology -- Ch. 2. Abnormalities of mammary growth and development -- Ch. 3. Inflammatory and reactive tumors -- Ch. 4. Specific infections -- Ch. 5. Papilloma and related benign tumors -- Ch. 6. Myoepithelial neoplasms -- Ch. 7. Adenosis and microglandular adenosis -- Ch. 8. Fibroepithelial neoplasms -- Ch. 9. Ductal hyperplasia: ordinary and atypical -- Ch. 10. Precancerous breast disease: epidemiologic, pathologic, and clinical considerations -- Ch. 11. In Situ (intraepithelial) carcinoma: an overview -- Ch. 12. Staging of breast carcinoma -- Ch. 13. Intraductal carcinoma -- Ch. 14. Invasive duct carcinoma: assessment of prognosis, morphologic prognostic markers, and tumor growth rate -- Ch. 15. Tubular carcinoma -- Ch. 16. Papillary carcinoma -- Ch. 17. Medullary carcinoma -- Ch. 18. Carcinoma with metaplasia -- Ch. 19. Squamous carcinoma -- Ch. 20. Mucinous carcinoma -- Ch. 21. Apocrine carcinoma -- Ch. 22. Mammary carcinoma with endocrine features -- Ch. 23. Small cell (oat cell) carcinoma -- Ch. 24. Secretory carcinoma -- Ch. 25. Mammary carcinoma with osteoclast-like. giant cells -- Ch. 26. Cystic hypersecretory carcinoma and cystic hypersecretory hyperplasia -- Ch. 27. Adenoid cystic carcinoma -- Ch. 28. Cribriform carcinoma -- Ch. 29. Lipid-rich carcinoma -- Ch. 30. Gylcogen-rich carcinoma -- Ch. 31. Invasive micropapillary carcinoma -- Ch. 32. Paget's disease of the nipple -- Ch. 33. Lobular carcinoma In Situ and atypical lobular hyperplasia -- Ch. 34. Invasive lobular carcinoma -- Ch. 35. Unusual clinical presentations of carcinoma -- Ch. 36. Metastases in the breast from nonmammary malignant neoplasms -- Ch. 37. Benign proliferative lesions of the male breast -- Ch. 38. Carcinoma of the male breast -- Ch. 39. Breast tumors in children -- Ch. 40. Benign mesenchymal neoplasms -- Ch. 41. Sarcoma -- Ch. 42. Lymphoid and hematopoietic tumors -- Ch. 43. Pathologic effects of therapy -- Ch. 44. Cutaneous neoplasms -- Ch. 45. The pathology of axillary and intramammary lymph nodes -- Ch. 46. Pathologic examination of breast and lymph node specimens.
  • Anatomy and physiologic morphology -- Abnormalities of mammary development and growth -- Inflammatory and reactive tumors -- Specific infections -- Papilloma and related benign lesions -- Myoepithelial neoplasms -- Adenosis and microglandular adenosis -- Fibroepithelial neoplasms -- Ductal hyperplasia: usual and atypical -- Precarcinomatous breast disease: epidemiologic, pathologic, and clinical considerations -- Ductal carcinoma In Situ -- Invasive ductal carcinoma: assessment of prognosis with morphologic and biologic markers -- Tubular carcinoma -- Papillary carcinoma -- Medullary carcinoma -- Carcinoma with metaplasia and low-grade adenosquamous carcinoma -- Squamous carcinoma -- Mucinous carcinoma -- Apocrine carcinoma -- Mammary carcinomas with endocrine features -- Small cell carcinoma -- Secretory carcinoma -- Mammary carcinoma with osteoclast-like giant cells -- Cystic hypersecretory carcinoma and cystic hypersecretory hyperplasia -- Adenoid cystic carcinoma -- Invasive cribriform carcinoma -- Lipid-rich carcinoma -- Glycogen-rich carcinoma -- Invasive micropapillary carcinoma -- Paget disease of the nipple -- Lobular carcinoma In Situ and atypical lobular hyperplasia -- Invasive lobular carcinoma -- Unusual clinical presentation of carcinoma -- Metastases in the breast from nonmammary neoplasms -- Benign proliferative lesions of the male breast -- Carcinoma of the male breast -- Breast tumors in children -- Benign mesenchymal neoplasms -- Sarcoma -- Lymphoid and hematopoietic neoplasms of the breast -- Pathologic effects of therapy -- Cutaneous neoplasms -- The pathology of axillary and intramammary lymph nodes -- Pathologic examination of breast and lymph node specimens, including sentinel lymph nodes -- Molecular classification and testing of breast carcinoma.
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  • Fundamental clinical concepts -- Critical management principles -- Cardinal presentations -- Trauma -- General concepts -- System injuries -- Orthopedic lesions -- Soft tissue injuries -- Violence and abuse -- Medicine and surgery -- Head and neck disorders -- Pulmonary system -- Cardiac system -- Vascular system -- Gastrointestinal system -- Genitourinary and gynecologic systems -- Neurology -- Psychiatric and behavioral disorders -- Immunologic and inflammatory -- Hematology and oncology -- Metabolism and endocrinology -- Infectious diseases -- Environment and toxicology -- Environment -- Toxicology -- Special populations -- The pediatric patient -- The pregnant patient -- The geriatric patient -- The patient with compromised immune function -- The patient with an organ transplant -- The alcoholic and substance abuse patient -- The developmentally or physically disabled patient -- The problem patient -- Emergency medical services -- The practice of emergency medicine -- Bonus online content -- Youth, violence, and street gangs -- Medical literature and evidence-based medicine -- Multiculturalism and care delivery -- Bioethics -- End of life -- Emergency medical treatment and active labor act and medicolegal issues -- Wellness, stress, and the impaired physician.
  • Epidemiology, genetics, and biological factors of rotator cuff tears / Longo, U.G. ... [et al.] -- Biomechanics of the rotator cuff : European perspective / Longo, U.G. ... [et al.] -- Role of biomechanics in rotator cuff pathology : North American perspective / Karas, V.; Cole, B.J.; Wang, V.M. -- The scapula in rotator cuff disease / Ben Kibler, W. -- Instability and rotator cuff tear / Porcellini, G. ... [et al.] -- Growth factors and tendon healing / Oliva, F. ... [et al.] -- Autologous blood products in rotator cuff repair / Mei-Dan, O.; Carmont, M.R. -- Tendinopathy of the long head of the biceps / Snyder, G.M.; Mair, S.D.; Lattermann, C. -- Conservative treatment and rotator cuff tear progression / Longo, U.G. ... [et al.] -- Operative management of partial- and full-thickness rotator cuff tears -- Franceschi, F. ... [et al.] -- Subscapularis tears / Longo, U.G. ... [et al.] -- Single- and double-row repair for rotator cuff tears -- biology and mechanics / Papalia, R. ... [et al.] -- Arthroscopic transosseous rotator cuff repair / Longo, U.G. ... [et al.] -- Treatment options for chronic retracted degenerative rotator cuff tears / Deering, S.J.; Mair, S.D.; Lattermann, C. -- Synthetic augmentation in massive rotator cuff tears / Longo, U.G. ... [et al.] -- Understanding and preventing complications in repairing rotator cuff tears / Osti, L. ... [et al.].
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    V. I. Basic science. Diagnosis. Surgical anatomy and surgical approaches. Spinal fusion and instrumentation. The child's spine. Arthritis and inflammatory disorders -- V. II. Cervical degenerative disorders. Thoracic and lumbar disc disease. Spinal stenosis. Adult deformity. Spine trauma. Afflictions of the vertebrae. Spinal cord. Complications. Failed surgery. Rehabilitation.
  • Rothman-Simeone The Spine. 6th ed. v. 1-2, 2011.
    v. 1. Basic science -- Diagnosis -- Surgical anatomy and approaches -- The child's spine -- Arthritis and inflammatory disorders -- Cervical degenerative disorders -- Thoracic and lumbar disc disease -- Minimally invasive surgery -- v. 2. Spinal stenosis -- Spinal fusion and instrumentation -- Adult deformity -- Spine trauma -- Afflictions of the vertebrae -- Spinal cord -- Complications -- Failed surgery -- Chronic pain/rehabilitation.
  • Infectious diseases -- Parasitic diseases -- Nutritional diseases -- Disorders of protein metabolism -- Disorders of carbohydrate metabolism -- Disorders of lipid metabolism -- Hematologic and cardiovascular disorders -- Dermatologic disorders -- Connective tissue disorders -- Skeletal disorders -- Phakomatoses -- Neurologic disorders -- Neoplasms -- Mechanical and nonmechanical injuries -- Unclassified diseases or conditions -- Anterior chamber -- Choroid -- Conjunctiva -- Cornea -- Extraocular muscles -- Eyelids -- Globe -- Intraocular pressure -- Iris and ciliary body -- Lacrimal system -- Lens -- Macula -- Optic nerve -- Orbit -- Retina -- Sclera -- Vitreous.
  • RT-PCR protocols 2002
    Springer Protocols
  • Rubella viruses 2007
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    Inflammation / Hedwig S. Murphy -- Repair, regeneration, and fibrosis / Gregory C. Sephel, Stephen C. Woodward -- Immunopathology / Jeffrey S. Warren, Douglas P. Bennett, Roger J. Pomerantz -- Neoplasia / Antonio Giordano ... [et al.] -- Developmental and genetic diseases / Anthony A. Killeen, Emanuel Rubin, David S. Strayer -- Hemodynamic disorders / Bruce M. McManus, Michael F. Allard, Robert Yanagawa -- Environmental and nutritional pathology / David S. Strayer, Emanuel Rubin -- Infectious and parasitic diseases / David A. Schwartz ... [et al.] -- Blood vessels / Avrum I. Gotlieb -- The heart / Jeffrey E. Saffitz -- The respiratory system / Mary Beth Beasley, William D. Travis, Emanuel Rubin -- The gastrointestinal tract / Frank A. Mitros, Emanuel Rubin -- The liver and biliary system / Raphael Rubin, Emanuel Rubin -- The pancreas / Gregory Y. Lauwers, Mari Mino-Kenudson, Raphael Rubin -- The kidney / J. Charles Jennette -- The lower urinary tract and male reproductive system / Ivan Damjanov -- The female reproductive system / Stanley J. Robboy, Maria J. Merino, George L. Mutter -- The breast / Ann D. Thor, Adeboye O. Osunkoya -- Hematopathology / Roland Schwarting, Steven McKenzie, Raphael Rubin -- The endocrine system / Maria Merino ... [et al.] -- Obesity, diabetes mellitus, metabolic syndrome / Barry J. Goldstein, Serge Jabbour, Kevin Furlong -- The amyloidoses / Robert Kisilevsky -- The skin / Craig A. Storm, David E. Elder -- The head and neck / Bruce M. Wenig -- Bones and joints / Benjamin L. Hoch, Michael J. Klein, Alan L. Schiller -- Skeletal muscle / Lawrence C. Kenyon, Mark T. Curtis -- The nervous system / John Q. Trojanowski, Lawrence Kenyon, Thomas W. Bouldin -- The eye / Gordon K. Klintworth -- Cytopathology / Hormoz Ehya, Marluce Bibbo.
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  • Incorporating and balancing advancing subspecialization is a significant challenge of modern surgery. The changes of surgical education and early subspecialization is a smaller spectrum of experience of graduating surgeons joining the rural workforce. Surgeons working in rural and remote hospitals, however, must be proficient in the great breadth of current surgical practice and face a number of challenges and demands that are specific to rural surgery. This textbook provides an update on the evidence and surgical techniques for the experienced rural surgeon and most importantly is a guideline for younger surgeons and surgical trainees joining the general surgical workforce in rural and remote areas around the world.
  • Surgical physiology -- Acute and critical care -- Soft tissue, hernia, and breast -- Endocrine surgery -- Alimentary tract -- Liver, biliary tract, pancreas, and spleen -- Cardiovascular and thoracic -- Subspecialties for the general surgeon -- Fundamentals of surgical technology -- Practice of surgery
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    Includes 80 biobibliographies of German, Baltic and Russian personal physicians.
  • Published in association with the Society for Vascular Surgery, Rutherford's Vascular Surgery presents state-of-the-art updates on all aspects of vascular health care. Extensively revised by many new authors to meet the needs of surgeons, interventionalists, and vascular medicine specialists, this medical reference book incorporates medical, endovascular and surgical treatment, as well as diagnostic techniques, decision making and fundamental vascular biology. Master the latest developments, techniques, and approaches with thorough updates on endovascular applications, vascular access, imaging, non-operative management, and much more.View clinical and physical findings and operative techniques more vividly with a full-color layout and images.Get answers you can depend on. Rutherford's delivers the world's most trusted information on all major areas of vascular health care, is written by international experts, and includes up-to-date bibliographies and annotated recommended references.
  • Part 1. Personal Views -- A Personal View / James M. Ryan -- A Personal Experience / Damian Douglas Keene -- The War in West Philadelphia / John P. Pryor -- Part 2. Weapons, Blast and Ballistics -- How Guns Work / Mark Byers, Kerry Starkey and Peter F. Mahoney -- The Effects of Bullets / Donald H. Jenkins -- Bombs, Mines, and Fragmentation / Toney W. Baskin and John B. Holcomb -- Cluster Munitions / Henry Dowlen -- Shaped Charges and Explosively Formed Projectiles / Jonathan Morrison and Peter F. Mahoney -- Suicide Bombs / Piers R. J. Page and Ian Greaves -- Blast Injury / Emrys Kirkman, Neal Jacobs, Giles R. Nordmann, Stuart Harrisson and Peter F. Mahoney, et al. -- Ballistic Protection / Alan Hepper, Daniel Longhurst, Graham Cooper and Philip Gotts -- Forensic Aspects of Ballistic Injury / Jeanine Vellema and Hendrik Scholtz -- Part 3. Trauma Systems -- Civilian Trauma Systems / Jason Smith -- The UK Military Trauma System / Timothy J. Hodgetts -- Part 4. Prehospital and the Emergency Room -- Triage / Rob Russell -- Prehospital Care / Mark Byers, John-Joe Reilly and Peter F. Mahoney -- Emergency Department Management / Jason Smith -- Imaging Triage for Ballistic Trauma / Jon David Simmons and Tracy R. Bilski -- Part 5. Advanced Resuscitation and Anaesthesia, Section -- Damage Control Resuscitation / Adam J. Brooks and Bryan A. Cotton -- Battlefield Analgesia / Aaron D. Nelson and Dominic J. Aldington -- Anesthesia for the Ballistic Casualty / Craig C. McFarland -- Regional Anesthesia for the Ballistic Trauma Victim / Dan Connor -- Part 6. Clinical Care -- Damage Control Surgery: Concepts / Mark J. Midwinter and Adam J. Brooks -- Management of Ballistic Trauma to the Head / Geoffrey S. F. Ling, Chris J. Neal and James M. Ecklund -- Spinal Injury / Neil Buxton -- Eyes / Robert A. H. Scott -- Maxillofacial Ballistic Injuries / Andrew Martin Monaghan -- Neck Injury / Matthew J. Borkon and Bryan A. Cotton -- Damage Control / Benjamin Braslow, Adam J. Brooks and C. William Schwab -- Management of Vascular Trauma / Kate Brown and Nigel Tai -- Damage Control Part III: Definitive Reconstruction / Steven R. Allen, Adam J. Brooks, Patrick M. Reilly and Bryan A. Cotton -- Penetrating Genitourinary Trauma / Jay J. Doucet and David B. Hoyt -- Burns / Alan Kay -- Management of Extremity Injuries / David E. Hinsley and Jon Clasper -- Ballistic Trauma in Children / Graeme Pitcher -- Ballistic Trauma in Pregnancy / Michael J. Socher and Peter E. Nielsen -- Managing Ballistic Injury in the NGO Environment / Ari K. Leppäniemi -- Part 7. Critical Care -- Critical Care for Ballistic Trauma in Austere Environments / Christian B. Swift and Geoffrey S. F. Ling -- Transfer and Evacuation / Robert D. Tipping and Jonathan Vollam -- Critical Care Management: The Patient with Ballistic Trauma / Tim Nutbeam and Damian Douglas Keene -- Critical Care Nursing at Role Four / Clare Dutton -- The Role of Nutrition in the Treatments of Injured Military Personnel / Susan Duff, Susan Price and Jennifer Gray -- Part 8. Reconstruction & Rehabilitation -- Role 4 and Reconstruction / Steven L. A. Jeffery and Keith Porter -- Conflict Rehabilitation / John Etherington -- Part 9. And Finally -- Have You Read MASH? / Peter F. Mahoney.
  • Sect. 1. Optical Imaging Technologies. Fluorescein angiography : basic principles and interpretation / Robert N. Johnson, et al. -- Clinical applications of diagnostic indocyanine green angiography / Giovanni Staurenghi, Ferdinando Bottoni, and Andrea Giani -- Optical coherence tomography / Carlos Alexandre de Amorim Garcia Filho, et al. -- Autofluorescence imaging / Monika Fleckenstein, Steffen Schmitz-Valckenberg, and Frank G. Holz -- Advanced imaging technologies / Pearse A. Keane, Humberto Ruiz-Garcia, and SriniVas R. Sadda -- Image processing / Michael Abramoff and Christine N. Kay -- Sect. 2. Retinal Diagnostics. Electrogenesis of the electroretinogram / Laura J. Frishman -- Clinical Electrophysiology / Yozo Miyake and Kei Shinoda -- Diagnostic ophthalmic ultrasound / Rudolf F. Guthoff, Leanne T Labriola, and Oliver Stachs -- Color vision and night vision / Dingcai Cao -- Visual acuity and contrast sensitivity / Gary S. Rubin -- Visual fields in retinal disease / Rajeev S. Ramchandran and Steven E. Feldon.

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