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  • 2006 Springer
    Roy, P.
    Attachment and cell entry of mammalian orthoreovirus / K.M. Guglielmi ... [et al.] -- Early steps in rotavirus cell entry / S. Lopez and C.F. Arias -- Early steps in avian reovirus morphogenesis / J. Benavente and J. Martinez-Costas -- Bluetongue virus assembly and morphogenesis / P. Roy and R. Noad -- Reovirus structure and morphogenesis / K.M. Coombs -- Rotavirus genome replication and morphogenesis : role of the viroplasm / J.T. Patton ... [et al.] -- Rotavirus proteins : structure and assembly / J.B. Pesavento ... [et al.] --- Structural studies on orbivirus proteins and particles / D.I. Stuart and J.M. Grimes -- Rotavirus assembly : an alternative model that utilizes and atypical trafficking pathway / S. Chwetzoff and G. Trugnan.
    Also available: Print – 2006
  • 2006 Springer
    Walsh, William R.
    Tendon repair and regeneration: an overview / Eric M. Bluman, Scott D. Allen, Paul D. Fadale -- Structure and function of ligaments, tendons, and joint capsule / Frederick H. Silver, Joseph W. Freeman, Gino Bradica -- Tendons of the hand: anatomy, repair, healing, and rehabilitation / Paul C. Stephens ... [et al.] -- Evolution of concepts in flexor tendon surgery of the hand / Randip R. Bindra -- Basic science of the shoulder ligaments / Louis J. Soslowsky and Jeffrey S. Cartmell -- History of cruciate ligaments: development of repair and reconstruction / Jon Karlsson -- Rotator cuff / Richard O. Evans, Peter J. Hughes, David H. Sonnabend -- Frozen shoulder / Peter J. Hughes, Richard O. Evans, Jerome A. Goldberg -- Capsular shrinkage of the shoulder: current clinical status / Andrew L. Wallace -- Biomechanical and clinical evaluation of tendons and ligaments / David Hartright ... [et al.] -- Healing of ligament and tendon to bone / Andreas Weiler, Sven Scheffler, Maria Apreleva -- Artificial ligaments / Andrew A. Amis -- Tendon and ligament fixation to bone / Christopher M. Hill, Yuehuei H. An, Frank A. Young -- Tissue engineering strategies for regeneration of the anterior cruciate ligament / Michael G. Dunn -- Gene therapy and ligament healing / Norimasa Nakamura.
  • v. 1-5, 1959-61.
    Martini, Aldo; Martini, Paolo.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012 Karger
    Garrido-Ramos, Manuel A.
    The Repetitive DNA Content of Eukaryotic Genomes / López-Flores, I.; Garrido-Ramos, M.A. -- Telomere Dynamics in Mammals / Silvestre, D.C.; Londoño-Vallejo, A. -- Drosophila Telomeres: an Example of Co-Evolution with Transposable Elements / Silva-Sousa, R.; López-Panadès, E.; Casacuberta, E. -- The Evolutionary Dynamics of Transposable Elements in Eukaryote Genomes / Tollis, M.; Boissinot, S. -- SINEs as Driving Forces in Genome Evolution / Schmitz, J. -- Unstable Microsatellite Repeats Facilitate Rapid Evolution of Coding and Regulatory Sequences / Jansen, A.; Gemayel, R.; Verstrepen, K.J. -- Satellite DNA Evolution / Plohl, M.; Meštrović, N.; Mravinac, B. -- Satellite DNA-Mediated Effects on Genome Regulation / Pezer, Ž.; Brajković, J.; Feliciello, I.; Ugarković, Đ. -- The Birth-and-Death Evolution of Multigene Families Revisited / Eirín-López, J.M.; Rebordinos, L.; Rooney, A.P.; Rozas, J. -- Chromosomal Distribution and Evolution of Repetitive DNAs in Fish / Cioffi, M.B.; Bertollo, L.A.C..
  • 2013 Springer
    Fitzgerald, Paul B.; Daskalakis, Z. Jeff.
    Repetitive transcranial magnetic stimulation (rTMS) treatment is increasingly being used in the management of patients with depression. Since the approval of one rTMS device in the United States in 2008, clinical services using this equipment have become relatively common there, and services are also being developed in a variety of other countries. However, considerable ignorance exists about the treatment in general psychiatric practice. This concise clinical guide will serve as a reference and practical tool for clinicians working with or learning about this treatment technique. The opening chapters provide basic information on the history and development of rTMS treatment and its mechanism of action. Use of the treatment in depression is then addressed in detail, with explanation of the evidence base and discussion of clinical issues such as selection of patients and type of treatment, dose, and treatment duration. Side-effects of treatment are explored, and careful consideration is given to various practical issues concerning the establishment of rTMS treatment programs and the training of clinicians. The final chapters will provides a brief overview of potential rTMS applications in other psychiatric conditions and some background on the use of related treatments, such as transcranial direct current stimulation.
  • 2011 Springer
    Dormitzer, Philip R.; Mandl, Christian W.; Rappuoli, Rino.
    Live vaccines and their role in modern vaccinology / Gordon Dougan, David Goulding, and Lindsay J. Hall -- Live attenuated vaccines : influenza, rotavirus and varicella zoster virus / Harry B. Greenberg and Ann M. Arvin -- Classical live viral vaccines / Thomas P. Monath -- Recombinant live vaccines to protect against the severe acute respiratory syndrome coronavirus / Luis Enjuanes ... [et al.] -- Live-attenuated Shigella vaccines. Is encouraging good enough? / Yves Germani and Philippe J. Sansonetti -- New generation BCG vaccines / Michael V. Tullius and Marcus A. Horwitz -- Basic science paves the way to novel safe and effective pestivirus vaccines / Norbert Tautz and Gregor Meyers -- Live attenuated influenza virus vaccines : NS1 truncation as an approach to virus attenuation / Natalie Pica, Peter Palese, and John Steel -- An attenuated HSV-1 live virus vaccine candidate that is replication competent bu defective in epithelial cell-to-cell and neuronal spread / Elizabeth E. Zumbrun and Harvey M. Frieman -- Live attenuated vaccines for respiratory syncytial virus / Michael N. Teng -- Live attenuated cholera vaccines : flagella and reactogenicity / D. Ewen Cameron and John J. Mekalanos -- Replication-defective herpes simplex virus mutant strains as genital herpes vaccines and vaccine vectors / David M. Knipe -- Nucleic acid-based infections and pseudo-infectious flavivirus vaccines / Justin A. Roby, Roy A. Hall, and Alexander A. Khromykh -- Application of cleavage activation mutants of influenza virus as live vaccines / Juergen Stech and Hans-Dieter Klenk -- Alphavirus particle-based vaccine vectors / Scott J. Balsitis, Clayton W. Beard, and Peter W. Mason -- Recombinant chimeric, live attenuated vaccines against flaviviruses and alphaviruses / Thomas P. Monath.
  • v. 1-3, 1967-. Google Books
    Fulltext (v. 2) Google Books
    Fulltext (v. 2) Google Books
    Also available: Print – v. 1-3, 1967-.
  • v. 1, 1940.
    PrintStatus: Not Checked OutLane Catalog Record
  • Silverchair
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
    Also available: Print – 1970-<2012>
  • v. 1-2, 1994. NIH
    Volume 2 has country-by-country analysis.
  • 1973-
    v. 1. Results of the initial evaluation phase.
  • 2011 WHO
    The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
    Also available: Print – 2011
  • v. 1-<8>, 1985-<1986> Google Books
    v. 1. Executive summary -- v. 2. Crosscutting issues in minority health -- v. 3. Cancer -- v. 4. Cardiovascular and cerebrovascular disease 2 v. -- v. 5. Homicide, suicide, and unintentional injuries -- v. 6. Infant mortality and low birthweight -- v. 7. Chemical dependency and diabetes -- v. 8. Hispanic health issues/Inventory of DHHS programs/Survey of non-federal community.
  • The report includes listings of substances, divided into two categories: known human carcinogens and substances reasonably anticipated to be human carcinogens.
  • NLM
    Stewart, William H.
    Also available: Print – 1967
  • 2006
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007 Springer Protocols
    Anson, Donald S.
    Methodologies for staining and visualization of [beta]-galactosidase in mouse embryos and tissues / Siobhan Loughna and Deborah Henderson -- Immunohistochemical detection of [beta]-galactosidase or green fluorescent protein on tissue sections / Philip A. Seymour and Maike Sander -- Detection of reporter gene expression in murine airways / Maria Limberis, Peter Bell, and James M. Wilson -- Three-dimensional analysis of molecular signals with episcopic imaging techniques / Wolfgang J. Weninger and Timothy J. Mohun -- Fluorescent proteins for cell biology / George H. Patterson -- Detection of GFP during nervous system development in Drosophila melanogaster / Karin Edoff, James S. Dods, and Andrea H. Brand -- Autofluorescent proteins for flow cytometry / Charles G. Bailey and John E. J. Rasko -- Fluorescent protein reporter systems for single-cell measurements / Steven K. Dower, Eva E. Qwarnstrom, and Endre Kiss-Toth -- Subcellular imaging of cancer cells in live mice / Robert M. Hoffman -- Noninvasive imaging of molecular events with bioluminescent reporter genes in living subjects / Pritha Ray and Sanjiv Sam Gambhir -- Green fluorescent protein as a tracer in chimeric tissues : the power of vapor fixation / Harald Jockusch and Daniel Eberhard.
  • 2007 Springer
    Funahashi, S.
  • 2013 IngentaConnect
    Eraso, Yolanda.
    Also available: Print – 2013
  • 2006 Springer
    Leigh, Steven R.; Swedell, Larissa.
    Perspectives on reproduction and life history in baboons / Larissa Swedell & Steven R. Leigh -- Infant mortality, paternity certainty, and female reproductive strategies in hamadryas baboons / Larissa Swedell & Julian Saunders -- Female behavioral strategies of hybrid baboons in the Awash National Park, Ethiopia / Jacinta C. Beehner & Thore J. Bergman -- Hybrid baboons and the origins of the hamadryas male reproductive strategy / Thore J. Bergman -- The social and ecological flexibility of Guinea baboons : implications for Guinea baboon social organization and male strategies / Anh Galat-Luong, Gérard Galat & Suzanne Hagell -- Social organization, reproductive systems, and mediation of baboon endogenous virus (BaEV) copy number in gelada, hamadryas, and other Papio baboons / Monica Uddin, Jane E. Phillips-Conroy & Clifford J. Jolly -- Reproduction, mortality, and female reproductive success in chacma baboons of the Okavango Delta, Botswana / Dorothy L. Cheney ... [et al.] -- Maternal characteristics and offspring growth in chacma baboons : a life-history perspective / Sara E. Johnson -- Whose life is it anyway? Maternal investment, developmental trajectories, and life history strategies in baboons / Louise Barrett, S. Peter Henzi & John E. Lycett -- Ontogeny, life history, and maternal investment in baboons / Steven R. Leigh & Robin M. Bernstein -- Testicular size, developmental trajectories, and male life history strategies in four baboon taxa / Clifford J. Jolly & Jane E. Phillips-Conroy -- The evolutionary past and the research future : environmental variation and life history flexibility in a primate lineage / Susan C. Alberts & Jeanne Altmann.
  • bk. 4-5, 1972.
    Austin, C. R.; Short, R. V.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Germ cells and fertilization.--v. 2. Embryonic and fetal development.--v. 3. Hormones in reproduction.--v. 4. Reproductive patterns.--v. 5. Artificial control of reproduction.--Book 6. The evolution of reproduction. --Book 8. Human sexuality.
  • 2011 ScienceDirect
    Gupta, Ramesh C.
    Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • 2006 ScienceDirect
    Branch, D. Ware; Lockshin, Michael.
  • 2009 Springer
    Chedrese, Pedro J.
    Basis for molecular reproductive biology -- Introduction to the molecular organization of the endocrine/reproductive system -- Extracellular signaling receptors -- Molecules that transmit information into the cell: the intracellular signaling pathways -- Introduction to molecular biology: structure and function of the macromolecules of genetic information -- Regulation of gene expression -- Molecular basis of abnormal phenotype -- Tools of molecular reproductive biology -- Recombinant DNA technology -- Techniques for DNA analysis -- Analyzing gene expression -- DNA microarray analysis -- Computer assisted analysis of genes -- Introduction to gene therapy -- Molecular regulation of reproductive hormones -- GnRH-GnRH-receptor system in the mammalian female reproductive tract -- FSH: one hormone with multiple forms, or a family of multiple hormones -- FSH receptor: one receptor with multiple forms or a family of receptors -- Regulation of the early steps in gonadal steroidogenesis -- Prostaglandins and their mechanisms of action in the cyclic ovary -- Androgens: molecular basis and related disorders -- Leptin as a reproductive hormone -- Neurosteroids and sexual behavior and reproduction -- Molecular regulation of the reproductive organs and tissues -- Autocrine and paracrine regulation of the ovary -- Ovarian endocrine activity: role of follistatin, activin, and inhibin -- Hormonal and molecular regualtion of the cytochrome P450 aromatase gene expression in the ovary -- Epigenetic mechanisms of ovarian gene regulation -- Ovarian function and failure: the role of the oocyte and its molecules -- Molecular control of corpus luteum function -- Molecular landscape of spermatogonial stem cell renewal, meiotic sex chromosome inactivation, and spermatic head shaping.
  • 2010 Springer
    Carrell, Douglas T.; Peterson, C. Matthew.
    Characteristics of a successful R.E.I. clinic and laboratory -- Assisted reproductive technology practice management -- Collaboration within the reproductive endocrinology and infertility practice: integration of laboratory and clinic operations -- Informed consent in advanced reproductive technology -- Reproductive laboratory regulations, certifications and reporting systems -- Successfully integrating the FDA regulations into your practice -- Psychosocial consequences of infertility and treatment -- A live baby or your money back: the marketing of in vitro fertilization procedures -- Ovulation: a molecular view -- Clinical evaluation of female factor infertility -- Polycystic ovary syndrome -- The current status for Metformin use in reproductive medicine -- Clinical aspects of endometriosis -- Common endocrinopathies in reproductive endocrinology -- Acquired uterine factors and infertility -- Mullerian (paramesonephric) anomalies and associated Wolffian (mesonephric) duct malformations -- Recurrent miscarriage -- Laparoscopy in the diagnosis and treatment of female infertility -- Turner syndrome -- Errors in chromosome segregation during oogenesis and early embryogenesis -- An overview of sperm production -- Meiotic recombination and errors during spermatogenesis -- Clinical evaluation and treatment of male factor infertility -- Semen analysis: essentials for the clinician -- Sperm capacitation, the acrosome reaction, and fertilization -- Advanced tests of sperm function -- Genetic testing of male infertility Varicocele and male infertility -- Sperm retrieval techniques -- The clinical utility of the evaluation of sperm chromatin -- Artificial insemination: intrauterine insemination -- Sperm preparation for artificial insemination -- Sperm banking, donation, and transport in the age of assisted reproduction: federal and state regulation -- Reproductive treatment of HIV-1 discordant couples -- Ovulation induction -- Transvaginal sonography in reproductive endocrinology and infertility -- Establishing the IVF laboratory: a systems view -- Preparation and selection of sperm for IVF and ICSI -- The genetic and epigenetic contributions of sperm to early embryogenesis -- Micromanipulation of human oocytes and embryos: applications of intracytoplasmic sperm injection and assisted hatching in infertility treatment -- Embryo culture techniques -- In-vitro maturation of human oocytes -- Integrating preimplantation genetic diagnosis into the ART laboratory -- Evaluation and selection of preimplantation embryos for transfer -- Embryo transfer in IVF: evidence-based clinical practice -- Cryopreservation of human oocytes and embryos -- Preserving fertility -- Ovarian hyperstimulation syndrome -- Pregnancy outcomes in infertile couples -- The impact of complementary medicine on in-vitro fertilization -- Designing a clinical research infrastructure -- Integrating research into a clinical practice -- Research regulations: the role of the Institutional Review Board -- Technology transfer and its role in the practice of reproductive endocrinology and infertility -- The environment and reproduction: endocrine disruption, reproductive impairment, and epigenetics.
  • 2010
    Merrill, Ray.
    PrintStatus: Not Checked OutLane Catalog Record
    Foundations of reproductive epidemiology -- Environments in reproductive epidemiology -- Research process in reproductive epidemiology -- Surveillance in reproductive epidemiology -- Descriptive reproductive health indicators -- Study designs in reproductive epidemiology -- Causal inference in reproductive epidemiology -- Nutrition and reproductive health -- Contraception and reproductive health -- Mercury, lead, environmental estrogens, and reproductive health -- Psychosocial factors and reproductive health -- Early childbearing : trends and consequences -- Cancer risk associated with early and late maternal age at first birth.
  • 2012 Springer
    Quinn, Gwendolyn P.; Vadaparampil, Susan T.; Zebrack, Brad.
    Principles of cancer treatment: impact on reproduction -- Fertility preservation options for females -- Options for fertility preservation in men and boys with cancer -- Contraception and cancer treatment in young persons -- Sexual health during cancer treatment -- Unique reproductive concerns of young women with breast cancer -- Pregnancy and cancer -- Preimplantation genetic diagnosis for hereditary cancers -- Non-traditional family building planning -- Parenting with cancer I: developmental perspective, communication, and coping -- Parenting with cancer II: parenting at different stages of illness -- Pediatric oncology and reproductive health -- Institutional approaches to implementing fertility preservation for cancer patients -- Patient provider communication and reproductive health -- Fertility preservation in cancer patients: ethical considerations -- Legal issue and of assisted reproductive technologies.
    Also available: Print – 2012
  • 2007 Springer
    Hens, Luc; Howard, Vyvyan; Nicolopoulou-Stamati, P.
    Introduction -- Environmental Impact on Reproductive Health, Recent Trends and Developments / P. Nicolopoulou-Stamati and N.J. Lelos. Section 1: The Link Between Reproductive Health and Environment. -- Epidemiological Studies on the Relationship between Semen Quality and Environmental Chemicals: Historic and Contemporary Compounds / R. Hauser and J.D. Meeker -- Environment and Fertility / P. Saldiva. Section 2: Reproductive Health Effects. -- Male Reproductive Status and its Relationship with Man-Made, Hormone-Disrupting Substances: Studies In Flanders, Belgium / W. Dhooge, F. Eertmans, A. Mahmoud, and F. Comhaire -- Potential Impact of the Environment on the Male Reproductive Function: The Example Of Cryptorchidism / E. Huyghe, R. Mieusset and P.F. Thonneau -- Advanced Glycation End Products in Polycystic Ovarian Syndrome / E. Diamanti-Kandarakis, C. Piperi, and P. Nicolopoulou-Stamati -- Oocytes and Ovarian Follicles as Targets of Endocrine Disrupters: Consequences for Reproductive Health / F. Gandolfi, T.A.L. Brevini, and F. Cillo. Section 3: Pollutants And Exposure. -- Non-Pesticide Endocrine Disrupters and Reproductive Health / S. Corsolini -- Medical Drugs Impairing Fertility / N. Pandiyan -- Impact of Air Pollution on Reproductive Health in Northern Bohemia / J. Rubes, S.G. Selevan, R.J. Sram, D.P. Evenson, and S.D. Perreault. Section 4: Policy Instruments And Issues. -- Pesticides as Endocrine Disrupters: Identification of Hazards for Female Reproductive Function / M. Rescia and A. Mantovani -- Assessment of Fertility and Other Health Impacts for Selected Pollutants in Flanders: Opportunities and Limitations / J. De Wit, A. Verspecht and L. Hens -- Problems in Assessing Low Dose Effects of Endocrine Disrupters / A. Gies -- Getting the Message Across - WWFs and ISDEs Perspectives on Communication Strategies to Reduce Exposures to Hazardous Chemicals / G. Lyons and P. Illig -- Environmental Ethics and Fertility in Early Cultures and The Industrial Age / A. Katsivelaki and C.E. Sekeris. Section 5: Regional Aspects. -- Reproductive Health Problems in the Greater Athens Area / D.A. Adamopoulos and E. Koukkou -- Environment and Reproductive Health in Bulgaria / S. Stoyanov and E. Terlemesian.
  • 2006
    PrintStatus: Not Checked OutLane Catalog Record
    About these guidelines -- Introduction -- Indicators-an overview in the context of global monitoring -- Generation, interpretation and analysis of the shortlisted national reproductive health indicators -- 1. Total fertility rate -- 2. Contraceptive prevalence -- 3. Maternal mortality ratio -- 4. Antenatal care coverage -- 5. Births attended by skilled health personnel -- 6. Availability of basic essential obstetric care -- 7. Availability of comprehensive essential obstetric care -- 8. Perinatal mortality rate -- 9. Prevalence of low birth weight -- 10. Prevalence of positive syphilis serology in pregnant women -- 11. Prevalence of anaemia in women -- 12. Percentage of obstetric and gynaecological admissions owing to abortion -- 13. Reported prevalence of women with genital mutilation -- 14. Prevalence of infertility in women -- 15. Reported incidence of urethritis in men -- 16. Prevalence of HIV infection in pregnant women -- 17. Knowledge of HIV-related preventive practices -- Annex 1. Millennium Development Goals and associated targets -- Annex 2. The selection criteria for the shortlist of indicators.
  • 2014 Springer
    Brown, Janine L.; Comizzoli, Pierre; Holt, W. V.
    Part 1. Introduction. Reproductive science as an essential component of conservation biology / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- "Mayday mayday mayday", the Millennium Ark is sinking? / Steven L. Monfort -- Part 2. The big picture: can species survive and adapt in a changing world? Climate change, extinction risks, and reproduction of terrestrial vertebrates / Cynthia Carey -- Impacts of endocrine disrupting chemicals on reproduction in wildlife / Emmelianna Kumar and William V. Holt -- The role of genomics in conservation and reproductive sciences / Warren E. Johnson and Klaus Koepfli -- The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction / Agustín F. Fernández, Estela García Toraño, Rocío González Urdinguio, Abel Gayo Lana, Ignacio Arnott Fernández, and Mario F. Fraga -- The black-footed ferret: on the brink of recovery? / Rachel M. Santymire, Travis M. Livieri, Heather Branvold-Faber, and Paul E. Marinari -- Comparative reproductive biology of elephants / Janine L. Brown -- The koala (Phascolarctos cinereus): a case study in the development of reproductive technology in a marsupial / Stephen D. Johnston and William V. Holt -- Reproduction and advances in reproductive studies in carnivores / Katarina Jewgenow and Nucharin Songsasen -- Methods to examine reproductive biology in free-ranging, fully-marine mammals / Janet M. Lanyon and Elizabeth A. Burgess -- Amphibian declines in the twenty-first century: why we need assisted reproductive technologies / John Clulow, Vance L. Trudeau, and Andrew J. Kouba -- The reality, use and potential for cryopreservation of coral reefs / Mary Hagedorn and Rebecca Spindler -- Recent advances and prospects in germplasm preservation of rare and endangered species / Pierre Comizzoli and William V. Holt -- Sperm DNA fragmentation and its role in wildlife conservation / Jaime Gosálvez, William V. Holt, and Stephen D. Johnston -- Somatic cells, stem cells, and induced pluripotent stem cells: how do they now contribute to conservation? / Gabriela F. Mastromonaco, L. Antonio González-Grajales, Melissa Filice, and Pierre Comizzoli -- Biosafety in embryos and semen cryopreservation, storage, management and transport / A. Bielanski -- Fertility control in wildlife: review of current status, including novel and future technologies / Deborah Garside, Ayman Gebril, Manal Alsaadi, and Valerie A. Ferro -- Cloning the mammoth: a complicated task or just a dream? / Pasqualino Loi, Joseph Saragusty, and Grazyna Ptak -- Conclusions: environmental change, wildlife conservation and reproduction / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- Index.
    Also available: Print – 2014
  • 2015 Springer
    Li, Tin-Chiu; Metwally, Mostafa.
    This evidence-based book examines the role of reproductive surgery in the current age of IVF and in modern medical practice. The authors provide a detailed insight into surgical techniques and where such practices stand relative to other fertility treatments such as assisted conception techniques. Reproductive Surgery in Assisted Conception is a useful reference book for current practicing reproductive surgeons as well as those training in the field. It is also invaluable to other fertility practitioners wishing to gain more insight into how and when surgical intervention may be used as either a standalone fertility treatment or to improve success rates of other fertility treatments.
  • 2009 Springer
    Simonstein, Frida.
    Current status of assisted reproductive techniques (ART) / Ariel Revel -- The medicalization of reproduction : a 30 year retrospective / Søren Holm -- Conceiving a new right to procreate / Marleen Eijkholt -- 'Can't avoid it, can't afford it' : assisted reproduction in Israel and Bulgaria / Frida Simonstein and Ekaterina Balabanova -- Assisted reproduction in developing countries : the debate at a turning point / Effy Vayena -- Ethical and socio-cultural aspects that influence ART in Latin America / Ester Polak de Fried -- Women, work, and children : is there a solution? / Daniel Callahan -- Between fecklessness and selfishness : is there a biologically optimal time for motherhood? / Anna Smajdor -- Gendered futures : reproduction and production in women's lives / Harriet Bradley -- Is transferred parental responsibility legitimately enforceable? / Matti Häyry -- Reproduction, responsibility and rationality / Tom Buller -- Male or female we will create them : the ethics of sex selection for non-medical reasons / David Heyd -- Artificial reproductive technologies and the advent of the artificial womb / Frida Simonstein -- Human before sex : Ectogenesis as a way to equality / Tuija Takala -- The glass womb / Iain Brassington -- A survey of people's attitude towards the artificial womb and ectogenesis in Israel / Frida Simonstein and Michal Mashiach-Eizenberg.
  • 2013
    Brady, Jennifer Jean; Blau, Helen M.; Chen, Chang-Zheng; Sarnow, P.; Wernig, Marius.
    Reprogramming of somatic nuclei to a pluripotent state can be achieved by two approaches: somatic cell nuclear transfer (cloning) and transcription factor transduction to generate induced pluripotent stem cells (iPS). Early molecular events in reprogramming are not well understood, in large part due to the inefficiency of nuclear transfer and iPS generation. This inefficiency has led to the hypothesis that early reprogramming is a stochastic rather than a deterministic process. We hypothesized that iPS generation could be improved by the identification of early molecular events and pathways that may enhance reprogramming. In order to model reprogramming of fibroblasts towards pluripotency, we generated mouse embryonic stem cell X human fibroblast heterokaryons in which somatic cell pluripotency gene activation and promoter demethylation occurs rapidly and without cell division. We show that heterokaryon cell fusion based reprogramming is rapid and extensive, and that active DNA demethylation of the somatic OCT4 and NANOG promoters requires Activation Induced Deaminase. Heterokaryon bi-species RNA- Seq identified a role for a secreted factor which enhanced iPS generation and could replace constitutive viral expression of the reprogramming factor c-Myc. These data demonstrate that heterokaryons can serve as a discovery tool for novel reprogramming factors and that findings in cell fusion based reprogramming can inform early events in iPS generation. Mixed species heterokaryons are an attractive model system for investigating mechanisms of active DNA demethylation in the context of the mammalian genome and provide a viable approach for investigating early events in cellular reprogramming.
  • 2012 Springer
    Chen, Jian; Quinn, Peter J.; Wang, Xiaoyuan.
    "Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation."--Publisher's description.
  • 2012
    Vierbuchen, Thomas Scott; Beachy, Philip Arden; Chang, Howard Y.; Wernig, Marius; Wysocka, Joanna.
    Cellular differentiation and lineage commitment are considered to be robust and irreversible processes during development. However, recent work has shown that mouse and human fibroblasts can be reprogrammed to a pluripotent state with a combination of four transcription factors. This raised the question of whether transcription factors could directly induce other defined somatic cell fates, and not only an undifferentiated state. We hypothesized that combinatorial expression of neural-lineage-specific transcription factors could directly convert fibroblasts into neurons. Starting from a pool of nineteen candidate genes, we identified a combination of only three factors, Ascl1, Brn2 (also called Pou3f2) and Myt1l that suffice to rapidly and efficiently convert mouse embryonic and postnatal fibroblasts into functional neurons in vitro. These induced neuronal (iN) cells express multiple neuron-specific proteins, generate action potentials and form functional synapses. Similar methods can also convert human fibroblasts to functional iN cells, by forced expression of Ascl1, Brn2, Myt1l and NeuroD1. Generation of iN cells from non-neural lineages could have important implications for studies of neural development, neurological disease modelling and regenerative medicine.
  • 2006 ScienceDirect
    Møller, Aage R.
  • 2005 Springer
    Ueno, Ei.
  • 2010 WHO
    "This overview outlines the statutory background for WHO's research, identifies the milestones in health research over five decades, and discusses issues of both process and programs. This report also includes accounts of regional efforts in health research"--Publisher's description. African region; Eastern Mediterranean region; European region; South East Asia region; Western Pacific region; Pan American Health Organization
    Also available: Print – 2010
  • 2014 ebrary
    Ray, Joyce M.
    It has become increasingly accepted that important digital data must be retained and shared in order to preserve and promote knowledge, advance research in and across all disciplines of scholarly endeavor, and maximize the return on investment of public funds. To meet this challenge, colleges and universities are adding data services to existing infrastructures by drawing on the expertise of information professionals who are already involved in the acquisition, management and preservation of data in their daily jobs. Data services include planning and implementing good data management practices, thereby increasing researchers' ability to compete for grant funding and ensuring that data collections with continuing value are preserved for reuse. This volume provides a framework to guide information professionals in academic libraries, presses, and data centers through the process of managing research data from the planning stages through the life of a grant project and beyond. It illustrates principles of good practice with use-case examples and illuminates promising data service models through case studies of innovative, successful projects and collaborations.
  • 2013 Springer
    Smith, Daron; Wood, Dan.
    Research in Clinical Practice is a neat, pocket-sized reference guide examining how to get the most from actively participating in research. Including how to begin, avoiding pitfalls, whom to approach and what questions to ask - all significant practicalities for conducting research in the reader's area of interest. Each reader will learn how to make the best use of such a valuable time. Written by two experienced surgeons, both of whom achieved post graduate research degrees, Research in Clinical Practice, is an essential tool for clinicians embarking on a research project as well as those who are new to supervising researchers.
  • 1979-
    Simmons, Roberta G.
    PrintStatus: Not Checked OutLane Catalog Record
  • Springer, 2005
    Istrail, Sorin; Kasif, Simon; Mesirov, Jill; Miyano, Satoru; Pevzner, Pavel; Waterman, Michael S.
  • Springer, 2007
    Huang, Haiyan; Speed, T. P.
  • 2008 Springer
    Vingron, Martin; Wong, Limsoon.
  • Springer, 2006
    Apostolico, Alberto; Guerra, Concettina; Istrail, Sorin; Pevzner, Pavel; Waterman, Michael S.
  • 1979-
    Scheffler, Richard M.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008 Stanf Univ
    Topics include self-Management, self-Efficacy, health Status, and some diabetes-specific scales.
  • 2013 ScienceDirect
    De Yoreo, Jim.
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.
  • 2013 Springer
    Eliades, Theodore.
    The orthodontic literature includes many articles on basic science and engineering research techniques, but clinicians are typically unfamiliar with the principles underlying these techniques and may also lack the background knowledge required for a full appreciation of their role. This book comprehensively reviews a wide array of the research methods most frequently encountered in the literature, encompassing the areas of materials science and clinical and biological research. The various methods and techniques are carefully described, and their indications and limitations are explained. All of the information is up to date, reflecting latest developments.For practicing professionals, Research Methods in Orthodontics will be an ideal introduction to instrumental analysis and basic science research methods in the field. It will also serve as an excellent reference guide for researchers. By familiarizing orthodontists with the basics of research methods, the book will boost their ability to keep pace with developments in treatment approaches, materials, and techniques and assist in the transfer of relevant future findings into practice.
  • 2007
    Addington-Hall, Julia M.; Bruera, Eduardo D.; Higginson, Irene; Payne, Sheila.
    PrintStatus: Not Checked OutLane Catalog Record
    Ethical and practice issues in qualitative research / Frances Sheldon and Anita Sargeant -- Evaluating qualitative research / Michelle Crossley -- Mixed methods for evaluation research / Christine Ingleton and Sue Davies -- Ethnography / Jane Seymour -- Documentary analysis and policy / Margaret O'Connor -- How to develop a research question / Laura Kelly and Patrick Stone -- Writing a research proposal / Chris Todd -- How to gain research ethics approval / Peter Speck -- How to use a statistician / Malcolm Campbell -- How to write a paper / Julia M. Addington-Hall. Principles of designing clinical trials in palliative care / Michael I. Bennett -- Ethical and practical issues in designing and conducting clinical trials in palliative care / Yolanda Zuriarrain Reyna, Michael I. Bennett, and Eduardo Bruera -- Survey design / Julia M. Addington-Hall -- Survey research : methods of data collection, questionnaire design, and piloting / Julia M. Addington-Hall -- Experimental and quasi-experimental designs / Massimo Costantini and Irene J. Higginson -- Outcome measurement / Irene J. Higginson and Richard Harding -- Systematic reviews / Marjolein Gysels and Irene J. Higginson -- Qualitative methods of data collection and analysis / Sheila Payne --
  • 2013 ebrary
    Redman, Barbara Klug.
  • pt. A-B, 2011. ScienceDirect
    pt. B ScienceDirect
    Klotz, Martin G.; Stein, Lisa Y.
    Also available: Print – pt. A-B, 2011.
  • 2010 Karger
    Brewitt, H.
    Trefoil factor family peptide 3 at the ocular surface / Schulze, U.; Sel, S.; Paulsen, F.P. -- Cationic amino acid transporters and [beta]-defensins in dry eye syndrome / Jäger, K. ... [et al.] -- Antimicrobial peptides as a major part of the innate immune defense at the ocular surface / Garreis, F.; Gottschalt, M.; Paulsen, F.P. -- Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT) / Knop, N.; Knop, E. -- Intravital multidimensional real-time imaging of the conjunctival immune system / Gehlsen, U.; Hüttmann, G.; Steven, P. -- Generation of two- and three-dimensional lacrimal gland constructs / Schrader, S. ... [et al.] -- Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency / Pauklin, M. ... [et al.] -- Laser scanning confocal microscopy for conjunctival epithelium imaging / Jürgens, C. ... [et al.] -- Pollen enzymes degrade human tear fluid and conjunctival cells : an approach to understanding seasonal non-allergic conjunctivitis / Rabensteiner, D.F. ... [et al.] -- Towards a new in vitro model of dry eye : the ex vivo eye irritation test / Spöler, F.; Frentz, M.; Schrage, N.F. -- The lid margin is an underestimated structure for preservation of ocular surface health and development of dry eye disease / Knop, E. ... [et al.] -- Diagnostic markers of sjögrenʹs syndrome / Witte, T. -- Hyperosmolarity of the tear film in dry eye syndrome / Messmer, E.M.; Bulgen, M.; Kampik, A. -- Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action / Springs, C.
  • 2002 ScienceDirect
    Ogden, Thomas E.; Goldberg, Israel A.
    Part One: Beginning grantsmanship -- 1. The NIH and other sources of research support -- 2. A strong proposal -- 3. Proposal review -- 4. The R01 research grant -- 5. The abstract and specific aims -- 6. Background and significance -- 7. Preliminary studies -- 8. Research design and methods -- 9. The budget -- 10. Biographical sketch, research support, and resources -- 11. Human subjects -- 12. Animal subjects -- 13. Consortiums, contracts, consultants, and collaborators -- 14. Literature cited and appendixes -- 15. Revision of an unfunded proposal -- 16. Competing renewal of R01 projects (progress reports) -- 17. Proposal submission and supplementary materials -- 18. Your first grant award (R, F, or K) -- 19. Advice for beginners in academia. -- Part two: Advanced grantsmanship -- 20. Small business grants -- 21. Program project grants (P01) -- 22. Center grants -- 23. Construction grants -- 24. T32 institutional research training program grants -- 25. Instrumentation grants -- Appendix -- A. Information sources: private foundation and government web sites, and study section contacts -- B. Summary statements, reviewer comments, assignment, award, and triage letters -- C. Examples of figures from preliminary data -- D. Examples of design format -- E. Instructions to reviewers concerning human subjects -- F. Suggested reading.
  • 2015 ScienceDirect
    Suckow, Mark A.; Yates, Bill J.
    Ch. 1. Human subjects research protections -- Ch. 2. Investigational new drug and device exemption process -- Ch. 3. The institutional animal care and use committee -- Ch. 4. Biological hazards and select agents -- Ch. 5. Radiological hazards and lasers -- Ch. 6. Controlled substances: maintaining institutional compliance -- Ch. 7. Export controls and US research universities -- Ch. 8. Data management and research integrity -- Ch. 9. Intellectual property -- Ch. 10. Financial conflicts of interest in research -- Ch. 11. Good laboratory practices (GLPs) -- Ch. 12. Human embryonic stem cell research oversight: a confluence of voluntary self-regulation and shifting policy initiatives -- Index.
  • 2011 ebrary
    "Comprehensive research and a highly trained workforce are essential for the improvement of health and health care both nationally and internationally. Over the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph. D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum."--Publisher's description.
  • 2007
  • 2000
  • 2012 Springer
    Castanho, Miguel A. R. B.; Güner-Akdoğan, Gül.
  • 2014 AccessSurgery
    DaRosa, Debra A.; George, Brian C.; Harken, Alden H.; Klamen, Debra L.
    "Resident Readiness: General Surgery prepares you for success during your surgical internship. Inside is a full range of scenarios you may experience during your residency, supported by comprehension questions with detailed answer explanations and tips to help you remember. You will also learn the clinical problem-solving process so you can think quickly on your feet, especially when time is critical. With the book's step-by-step guidance, you will gain the confidence you need to perform at your best on Day One of your residency"-- Provided by publisher.
  • 2007
    Kirpalani, Haresh M.; Moore, Aideen M.; Perlman, Max.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2011 Springer
    Gwyther, Lisa P.; Resnick, Barbara; Roberto, Karen A.
    Resilience: definitions, ambiguities, and applications -- Successful aging and resilience: applications for public health and health care -- Resilience and personality disorders in older age -- What do we know about resilience in older adults?: an exploration of some facts, factors, and facets -- Psychological resilience -- Physiological resilience -- Using the arts to promote resiliency among persons with dementia and their caregivers -- Promoting worker resilience over the lifecourse -- Resilience in aging: cultural and ethnic perspectives -- Civic engagement: policies and programs to support a resilient aging society -- Strengthened by the spirit: religion, spirituality, and resilience through adulthood and aging -- Resilience in chronic illness -- The relationship between resilience and motivation -- The association between resilience and survival among Chinese elderly -- Fostering resilience in dementia through narratives: contributions of multimedia technologies -- Building resilience in mild cognitive impairment and early-stage dementia: innovative approaches to intervention and outcome evaluation -- African-American caregivers finding resilience through faith -- The age-friendly New York City project: an environmental intervention to increase aging resilience -- Promoting resilience in small-scale, homelike residential care settings for older people with dementia: experiences from the Netherlands and the United States -- A geriatric mobile crisis response team: a resilience-promoting program to meet the mental health needs of community-residing older people -- Optimizing resilience in the 21st century -- Resilience in the workplace: job conditions that buffer negative attitudes toward older workers.
  • 2011 Springer
    Pierce, Katherine J.; Zand, Debra H.
    (Publisher-supplied data) Historically, the diagnosis of deafness in a child has been closely associated with profound disability, including such typical outcomes as unmet potential and a life of isolation. A major shift away from this negative view has led to improved prospects for deaf children. Resilience in Deaf Children emphasizes not only the capability of deaf individuals to withstand adversity, but also their positive adaptation through interactions with parents, peers, school, and community. In this engaging volume, leading researchers and professionals pay particular attention to such issues as attachment, self-concept, and social competence, which are crucial to the development of all young people. In addition, the volume offers strategies for family members, professionals, and others for promoting the well-being of deaf children and youth. Coverage includes: Attachment formation among deaf infants and their primary caregivers. Deaf parents as sources of positive development and resilience for deaf infants. Enhancing resilience to mental health disorders in deaf school children. Strength-based guidelines for improving the developmental environments of deaf children and youth. Community cultural wealth and deaf adolescents resilience. Self-efficacy in the management of anticipated work-family conflict as a resilience factor among young deaf adults. Resilience in Deaf Children is essential reading for researchers, clinicians, and graduate students in clinical child, school, and developmental psychology as well as for allied researchers and professionals in such disciplines as school counseling, occupational therapy, and social work.
  • 2008 Springer
    Kirillov, Igor A.; Pasman, H. J.
  • 2013 Springer
    Bonavida, Benjamin.
    Introduction and generation of chimeric and humanized mAbs -- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment -- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs -- Mechanisms of antibodies-mediated responses, in vitro and in vivo -- Molecular Pathways -- Molecular Signatures -- Identification of resistance targets for intervention -- Various chemicals that can sensitize resistant tumor cells -- Other mAbs -- Proteasome inhibitors -- Divalent mAbs -- Antibodies coupled to chemical inhibitors -- Antibodies coupled to cytokines -- Nanoparticles with mAbs.
  • 2014 CRCnetBASE
    Ciccolo, Joseph T.; Kraemer, William J.
    "Resistance training is a form of strength training in which each effort is performed against a specific, opposing force generated by resistance. Increasing evidence-based research highlights the importance of not only aerobic exercise, but resistance training in the prevention, management, and treatment of many chronic conditions. This book presents research on the benefits of resistance training for chronic diseases/disorders. Chapters cover resistance training to treat cardiovascular disease, metabolic diseases, cancer, orthopedic diseases, and neuromuscular disorders"-- Provided by publisher.
  • 2013 Springer
    Mancia, Giuseppe.
    A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.
  • 2008 Springer
    Rossi, Adriano G.; Sawatzky, Deborah A.
    Also available: Print – 2008
  • 2005 Ovid
    Lo, Bernard.
    An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Confusing ethical distinctions -- Ethics committees and case consultations -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Incentives for physicians to decrease services -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Testing for genetic conditions -- Ethical issues in public health emergencies.
    Also available: Print – 2005
  • 2013 Ovid
    Lo, Bernard.
    "Every day clinicians encounter ethical dilemmas that have a direct impact on patient care. This timely Fourth Edition will give you expert guidance in approaching a wide range of ethical dilemmas and developing an action plan even when competing points of view have equal merit. Most chapters include real-life sample cases that the author walks through, discussing the salient issues and how to approach them." "This useful resource is a must-read for medical students and practicing professionals at every level of experience!"--BOOK JACKET.
  • 2009 Ovid
    Lo, Bernard.
    Section I. Fundamentals of clinical ethics -- An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- Section II. Shared decision making -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Section III. Decisions about life-sustaining interventions -- Confusing ethical distinctions -- Ethics consultations and ethics committees -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Section IV. The doctor-patient relationship -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Section V. Conflicts of interest -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Measures to control health care costs -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Section VI. Ethical issues in clinical specialties -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Ethical issues in genomic medicine -- Ethical issues in public health emergencies -- Ethical issues in cross-cultural care.
  • 2011
    Hu, Qicong; Nachury, Maxence; Nelson, W. J.; Pringle, John R.
    Septins are a conserved family of polymerizing GTP/GDP-binding proteins that were discovered in budding yeast as the scaffold for cytokinesis machinery and required for polarized membrane growth. In mammalian cells, they play diverse roles in cytokinesis, cell morphogenesis and as scaffolds and diffusion barriers. Septins are also implicated in many human diseases including cancer and neuropathies. In epithelial cells, formation and maintenance of cell polarity depend on protein sorting from the trans-Golgi network (TGN) and vesicle delivery to the plasma membrane. We show that in epithelial cells septin 2 (SEPT2) fibers colocalize with polyglutamylated (polyGlu) microtubule tracks where vesicles containing apical or basolateral proteins exit, and that SEPT2 maintains polyGlu-microtubule tracks and impedes the binding of tubulin to microtubule-associated protein 4 (MAP4) to facilitate vesicle transport. SEPT2 depletion gives rise to intracellular accumulation of apical and basolateral membrane proteins, a loss of polyGlu-microtubules, and fibroblast-shaped cells. Therefore, SEPT2 is required for polarized epithelia biogenesis. Small molecules that reversibly perturb septin organization and function would be valuable tools for dissecting septin functions and could be used for therapeutic treatment of septin-related diseases. Forchlorfenuron (FCF) is a plant cytokinin previously shown to disrupt septin localization in budding yeast. We show that FCF alters septin assembly in vitro without affecting either actin or tubulin polymerization. In live mammalian cells, FCF dampens septin dynamics, and induces the assembly of abnormally large septin structures. FCF has a low level of cytotoxicity, and these effects are reversed upon FCF wash-out. Significantly, FCF treatment induces mitotic and cell migration defects that phenocopy the effects of septin-depletion by siRNA. FCF would be a promising tool to study mammalian septin organization and functions. In animal cells, the primary cilium transduces extracellular signals through signaling receptors localized in the ciliary membrane, but how these ciliary membrane proteins are retained in the cilium is unknown. We found that ciliary membrane proteins were highly mobile, but their diffusion was impeded at the base of the cilium by a diffusion barrier. SEPT2 localized at the base of the ciliary membrane. SEPT2 depletion resulted in loss of ciliary membrane protein localization and Sonic hedgehog signal transduction, and inhibited ciliogenesis. Thus, SEPT2 is part of a diffusion barrier at the base of the ciliary membrane and is essential for retaining receptor-signaling pathways in the primary cilium. Having demonstrated that there is a diffusion barrier at the base of the primary cilium and ciliary membrane protein is highly mobile in the ciliary membrane, I sought to determine the unknown dynamics and mechanism of ciliary membrane proteins trafficking on ciliary membrane at single molecule level. Here, I used monovalent streptavidin-conjugated fluorophores to image a single ciliary membrane receptor on the ciliary membrane of live cell and resolve their dynamics. The ciliary membrane receptor appears to travel on ciliary membrane by intraflagellar trafficking (IFT) and more efforts are being devoted into studying the mechanisms for ciliary membrane trafficking.
  • 2006
    Hahn, S.; Kielhorn, J.; Koppenhöfer, J.; Mangelsdorf, Inge; Wibbertmann, A.
  • 2005 Springer
    Durairaj, Raj B.
  • 2012
    Alistar, Sabina Stefania; Bendavid, Eran; Brandeau, Margaret L.; Owens, Douglas K.
    Operations research and mathematical modeling can play a key role in informing high-cost, high-impact health policy decisions. This dissertation describes my research on resource allocation for infectious disease control. Resource allocation is especially difficult in this context because epidemics are nonlinear (preventing one infection now may prevent scores of future infections); interventions usually do not have additive effects; the relationship between investment and outcomes is generally nonlinear and epidemics vary across settings in terms of transmission modes and key risk groups. Hence, the problem of resource allocation for epidemic control is complex and cannot be solved by intuition alone. Decision makers have little guidance in choosing investment portfolios that will provide the maximum health benefits for their particular setting. In Chapter 1, I discuss the gap between the theory and the practice of resource allocation for epidemic control, and identify the key features necessary for a model to be useful in practice. In theoretical work presented in Chapter 2, I address the gap between epidemiological measures and the resource allocation decision. I present a new theoretical framework that quantifies the effects of investment in treatment and prevention interventions on a key epidemiological parameter, the reproductive rate of infection, which measures an outbreak's potential for becoming an epidemic. The approach uses production functions to account for nonlinearities of intervention scale-up effects. I develop analytical results characterizing the optimal solution and present illustrative examples with data for Uganda and Russia. I also present a simple structural estimation technique for evaluating the shape of production functions based on real-world data. In Chapter 3 I develop a dynamic compartmental model of interventions for HIV control in mixed HIV epidemics. I apply the model to analyze the tradeoffs between scaling up methadone substitution therapy for injection drug users and antiretroviral treatment for HIV-infected individuals in Ukraine, a representative case. I show that methadone is an economically attractive option for HIV control, and that excluding drug users from HIV programs significantly limits the benefits that can be obtained by scaling up these interventions. In Chapter 4 I describe a spreadsheet-based planning tool I have created in collaboration with the Joint United Nations Programme on HIV/AIDS (UNAIDS). The REACH (Resource Allocation for Control of HIV) model is designed for use by planners around the world in evaluating investment portfolios for HIV control. The tool is easy to use, includes optimization capability, and accounts for non-additive and nonlinear effects of interventions. I present illustrative implementation of the model for three settings (Uganda, Ukraine and Saint Petersburg, Russia). I also describe my ongoing work with UNAIDS decision makers to test and implement the model for regional and country-level HIV resource allocation. I conclude in Chapter 5 with remarks on the significance of the work and directions for future research.
  • 2010
    PrintStatus: Not Checked OutLane Catalog Record
    Full text print version of RDA offers a snapshot that serves as an offline access point to RDA.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.
    Also available: Print – 2015
  • 2007
    Beachey, Will.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    Dexter, James R.; Gold, Philip M.; Wilkins, Robert L.
    PrintStatus: Not Checked OutLane Catalog Record
    Introduction to patient assessment / Robert L. Wilkins, Philip M. Gold -- Introduction to respiratory failure / Robert L. Wilkins, James R. Dexter -- Asthma / Robert L. Wilkins, Philip M. Gold -- Chronic obstructive pulmonary disease / Robert L. Wilkins, Philip M. Gold -- Cystic fibrosis / N. Lennard Specht -- Hemodynamic monitoring and shock / Robert L. Wilkins, James R. Dexter -- Pulmonary thromboembolic disease / James R. Dexter -- Heart failure / Arthur B. Marshak, George H. Hicks -- Smoke inhalation injury and burns / George H. Hicks, Carl A. Eckrode -- Near drowning / William F. Galvin -- Acute respiratory distress syndrome / Robert L. Wilkins, James R. Dexter -- Chest trauma / George H. Hicks, Carl A. Eckrode -- Postoperative atelectasis / Thomas P. Malinowski -- Interstitial lung disease / N. Lennard Specht -- Neuromuscular diseases / N. Lennard Specht, Rebekah Bartos Specht -- Bacterial pneumonia / Robert L. Wilkins, James R. Dexter -- Pneumonia in the immunocompromised patient / Philip M. Gold, N. Lennard Specht -- Sleep disordered breathing / Enrique Gil -- Tuberculosis / James R. Dexter, Robert L. Wilkins -- Lung cancer / Gregory A.B. Cheek -- Appendix A: Normal laboratory values -- Appendix B: GOLD standards for diagnosing and treating patients with COPD -- Appendix C: Websites useful for learning information about the diagnosis and treatment of lung diseases.
  • 2009 Springer
    McLuckie, Angela.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.
    Also available: Print – 2015
  • 2015 Springer
    Pokorski, Mieczyslaw.
    Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children / Wrotek, T. Jackowska, and K. Pawlik -- Detection of respiratory tract pathogens with molecular biology methods / Wozniak-Kosek, J. Kosek, and B. Zielnik-Jurkiewicz -- Classical against molecular-genetic methods for susceptibility testing of antituberculotics / I. Porvaznik, J. Mokry, and I. Solovic -- Does customer information fulfill MEDDEV criteria in cases of product problems of in vitro diagnostics for infection testing? / Jürgen Hannig and Rüdiger Siekmeier -- Sodium and copeptin levels in children with community acquired pneumonia / August Wrotek, Teresa Jackowska, and Katarzyna Pawlik -- Etiological factors causing lower respiratory tract infections isolated from hospitalized patients / A. Guzek, Z. Rybicki, K. Korzeniewski, K. Mackiewicz, E. Saks, A. Chciałowski, and E. Zwolińska -- Antibiotic consumption pattern in the neonatal special care unit before and after implementation of the hospital's antibiotic policy / Nitsch-Osuch, D. Kurpas, E. Kuchar, K. Życińska, T. Zielonka, and K. Wardyn -- Respiratory tract infections in children in primary healthcare in Poland / E. Kuchar, K. Miśkiewicz, L. Szenborn, and D. Kurpas -- Impact of updated European consensus guidelines on the management of neonatal respiratory distress syndrome on clinical outcome of preterm infants / S. Smolarova, L. Kocvarova, K. Matasova, M. Zibolen, and A. Calkovska -- Index.
    Also available: Print – 2015
  • 2009- Springer
    Rounds, Sharon.
  • 2013 ScienceDirect
    McConnell, Alison.
    Respiratory Muscle Training: theory and practice is the world's first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts - theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge - and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (www.physiobreathe.com), which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via www.physiotec.ca), which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. Introductory overviews of respiratory and exercise physiology, as well as training theory Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation Evidence-based guidance on the implementation of inspiratory muscle resistance training Over 150 functional exercises that incorporate a breathing challenge www.physiobreathe.com - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec's RMT exercise module (via www.physiotec.ca)
  • 2008
    West, John B.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013 Springer
    Pokorski, Mieczyslaw.
    Also available: Print – 2013
  • 2013 Springer
    Pokorski, Mieczyslaw.
    Also available: Print – 2013
  • 2007 ScienceDirect
    Cane, Patricia.
  • 2008 Springer
    Lucangelo, Umberto.
  • 2009 Springer
    Shanley, Thomas P.; Wheeler, Derek S.; Wong, Hector R.
    Respiratory physiology -- Disorders of the pediatric chest -- Respiratory monitoring -- Bronchoscopy in the pediatric intensive care unit -- Acute lung injury and acute respiratory distress syndrome -- Mechanical ventilation -- Ventilator-induced lung injury -- Prone positioning -- High-frequency oscillatory ventilation -- Pulmonary surfactant: biology and therapy -- Nitric oxide -- Extracorporeal life support for children with acute respiratory failure -- Diseases of the upper respiratory tract -- Congenital airway and respiratory tract anomalies -- Status asthmaticus -- Bronchiolitis -- Pneumonia and empyema -- Pediatric lung transplantation -- Neuromuscular respiratory failure -- Diseases of the pulmonary vascular system.
  • 2015 Springer
    Pokorski, Mieczyslaw.
    This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.
    Also available: Print – 2015
  • 2013 WHO
    A health-care provider is likely to be the first professional contact for survivors of intimate partner violence or sexual assault. Evidence suggests that women who have been subjected to violence seek health care more often than non-abused women, even if they do not disclose the associated violence. They also identify health-care providers as the professionals they would most trust with disclosure of abuse. These guidelines are an unprecedented effort to equip healthcare providers with evidence-based guidance as to how to respond to intimate partner violence and sexual violence against women. They also provide advice for policy makers, encouraging better coordination and funding of services, and greater attention to responding to sexual violence and partner violence within training programmes for health care providers. The guidelines are based on systematic reviews of the evidence, and cover: 1. identification and clinical care for intimate partner violence 2. clinical care for sexual assault 3. training relating to intimate partner violence and sexual assault against women 4. policy and programmatic approaches to delivering services 5. mandatory reporting of intimate partner violence. The guidelines aim to raise awareness of violence against women among health-care providers and policy-makers, so that they better understand the need for an appropriate health-sector response. They provide standards that can form the basis for national guidelines, and for integrating these issues into health-care provider education.
    Also available: Print – 2013
  • 2008
    Chen, Chun-Chun.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2014 Springer
    Arnaldi, Simone.
    This book disentangles the complex meanings of responsibility in nanotechnology development by focusing on its theoretical and empirical dimensions. The notion of responsibility is extremely diversified in the public discourse of nanoscale technologies. Addressed are major disciplinary perspectives working on nanotechnology, e.g. philosophy, sociology, and political science, as well as the major multidisciplinary areas relevant to the innovation process, e.g. technology assessment and ethics. Furthermore, the interplay between such expertises, disciplines, and research programmes in providing a multidisciplinary understanding of responsibility is emphasized.
  • 2009 OSO
    Shamoo, Adil E.; Resnik, David B.
    Scientific research and ethics -- Ethical decision making -- Data acquisition and management -- Mentoring and collaboration -- Collaboration between academia and private industry -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The protection of human subjects in research -- Protecting vulnerable human subjects in research -- Genetics, cloning, and stem cell research -- International research.
  • Flanders, Jon.
  • 2012
    Chen, Michael Cunyuan; Gotlib, Ian H.; Knutson, Brian; Wagner, Anthony D.
    Insomnia is a prevalent and costly disorder of sleep-related distress, yet little is known about its etiology. To better understand the neurobiology underlying insomnia, we examined resting state and directed sleep brain activity in insomniacs and healthy controls using simultaneous blood oxygen level-dependent (BOLD) signal functional magnetic resonance imaging (fMRI) and electroencephalography (EEG). Using dual regression analysis of BOLD signal brain networks derived from independent component analysis, we found increased coactivation of the insula in salience networks in insomniacs compared to healthy controls. This increase was accompanied by altered EEG power in insomniacs compared to healthy controls, as well as altered BOLD connectivity signatures of EEG frequency bands. These results suggest that aberrant connectivity of the insula and salience networks contribute to neural dysfunction in insomnia.
  • 2009 ClinicalKey
    Hening, Wayne A.
    Introduction -- General introduction: Restless Legs Syndrome as a neurological conundrum -- Patient's perspective -- From 1685 to 2008: an introduction to Restless Legs Syndrome -- Restless Legs Syndrome as a movement disorder -- Restless Legs Syndrome and nocturnal myoclonus (periodic limb movements during sleep) -- Clinical science of Restless Legs Syndrome -- Basic science of Restless Legs Syndrome -- Epidemiology and genetics -- Epidemiology of Restless Legs Syndrome -- Genetics of Restless Legs Syndrome -- Pathophysiology -- Iron metabolic system -- Iron dysregulation in Restless Legs Syndrome -- Brain's dopaine systems and their relevance to Restless Legs Syndrome -- Neuroimaging in Restless Legs Syndrome -- Circadian rhythm of Restless Legs Syndrome -- Spinal cord, dopamine, opiates, and Restless Legs Syndrome -- Clinical science of Restless Legs Syndrome -- Diagnosis -- Diagnosis of Restless Legs Syndrome -- Differential diagnosis of Restless Legs Syndrome -- Periodic limb movements in sleep -- Sleep laboratory diagnosis of Restless Legs Syndrome -- Actigraph assessment of periodic leg movements and Restless Legs Syndrome -- Assessment of Restless Legs Syndrome features with standardized methods -- Comorbidities and special populations -- Restless Legs Syndrome and periodic limb movement disorder in childhood and adolescence -- Restless Legs Syndrome and pregnancy -- Restless Legs Syndrome and periodic limb movements in the elderly with and without dementia -- Restless Legs Syndrome in medical disorders -- Restless Legs Syndrome in neurological disorders -- Is the manifestation of the Restless Legs Syndrome related to a pain mechanism? -- Restless Legs Syndrome and psychiatric disorders -- Management -- Introduction to management of Restless Legs Syndrome -- Nonpharmacological considerations and treatment of Restless Legs Syndrome -- Dopaminergic therapy of Restless Legs Syndrome -- Opioid agents in the treatment of Restless Legs Syndrome -- Anticonvulsants in the treatment of Restless Legs Syndrome -- Iron treatment -- Additional agents and miscellaneous therapies -- Management of Restless Legs Syndrome in the hospital and during surgery -- Restless Legs Syndrome morbidity: sleep and quality of life -- History of the Restless Legs Syndrome Foundation.
  • 2006 Springer
    Brundin, Patrik; Olanow, C. W.
  • v. 2-, 1971- Springer
    Beermann, W.; Hennig, Wolfgang; Nover, Lutz; Oostra, Ben A.; Richter, Dietmar; Scheer, U.; Tiedge, Henri.
  • 2009 Wellcome Trust
    Crowther, S. M.; Reynolds, L. A.; Tansey, E. M.
  • 2009 Springer
    Shanley, Thomas P.; Wheeler, Derek S.; Wong, Hector R.
    Emergency Medical Services for Children / Derek S. Wheeler and Tom LeMaster -- Pediatric Cardiopulmonary Resuscitation / Vinay M. Nadkarni and Robert A. Berg -- Supplemental Oxygen and Bag-Valve-Mask Ventilation / Patricia Abboud, Jennifer Raake, and Derek S. Wheeler -- Assessment and Management of the Pediatric Airway / Derek S. Wheeler, James P. Spaeth, Renuka Mehta, Suriyanarayana P. Hariprakash, and Peter N. Cox -- Vascular Access / Jennifer Kaplan and Richard J. Brilli -- Shock: An Overview / Joseph A. Carcillo, Derek S. Wheeler, Neil W. Kooy, and Thomas P. Shanley -- Acute Respiratory Failure / Jennifer L. Turi and Ira M. Cheifetz -- Pediatric Transport Medicine / Derek S. Wheeler and W. Bradley Poss -- Withdrawal of Life Support / Kathleen L. Meert and Ashok P. Sarnaik -- Brain Death / Sam D. Shemie -- The Pathophysiology of Brain Death and Care of the Potential Organ Donor / Sam D. Shemie.
  • 2014 Springer
    Antonelli, Massimo; Gullo, A.; Ristagno, Giuseppe.
    Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.
  • 2006 CRCnetBASE
    Aggarwal, Bharat B.; Shishodia, Shishir.
  • 2008 Springer
    Hoyningen-Huene, Paul; Sankey, Howard; Soler, Lena.
  • 2012 Springer
    Dunn, James R.; O'Campo, Patricia.
    Explanations, philosophy and theory in health inequalities research: towards a critical realist approach -- Values and social epidemiologic research -- Population-based data and community empowerment -- Differences that matter -- Context -- Place-based stress and chronic disease: a systems view of environmental determinants -- How goes the neighbourhood? Rethinking neighbourhoods and health research in social epidemiology -- Application of two schools of social theory to neighbourhood, place and health research -- Locating politics in social epidemiology -- Research tools in action -- Structural violence and structural vulnerability within the risk environment: theoretical and methodological perspectives for a social epidemiology of HIV risk among injection drug users and sex workers -- Realist review methods for complex health problems -- Addressing health equalities in social epidemiology: learning from evaluation(s) -- Making a difference -- Knowledge translation and social epidemiology: taking power, politics and values seriously -- Community-academic partnerships and social change -- Producing more relevant evidence: applying a social epidemiology research agenda to public health practice.
  • 2010 Springer
    Cummings, Louise.
  • 2008 ClinicalKey
    Rogers, Adam H.; Duker, Jay S.
    Diabetes -- Age-related macular degeneration -- Vascular obstructions -- Pediatric -- Trauma -- Tumors -- Retinal detachment and allied diseases -- Vitreous -- Macular diseases -- Retinal dystrophies -- White dot syndromes -- Inflammatory diseases -- Infectious diseases.
  • 2009 ClinicalKey
    Bhavsar, Abdhish R.
    1 Scleral buckling surgery -- 2 Vitrectomy surgery -- 3 23-gauge vitrectomy -- 4 25-gauge vitrectomy -- 5 Epiretinal membrane surgery -- 6 Macular hole surgery -- 7 Proliferative diabetic retinopathy and vitreous hemorrhage -- 8 Surgical management for open-globe injuries -- 9 Surgery for proliferative vitreoretinopathy -- 10 Surgery for submacular hemorrhage -- 11 Intravitreal injections -- 12 Pneumatic retinopexy -- 13 Fluid-air exchange/fluid-gas exchange -- 14 Drainage of choroidal hemorrhage, detachment, or effusion s-- 15 Vitreous implants -- 16 Vitreous biopsy for endophthalmitis or cytology -- 17 Treatment of advanced retinopathy of prematurity: peripheral retinal ablation -- 18 Scleral buckle surgery for retinal detachment associated with neonatal retinopathy of prematurity -- 19 Vitrectomy surgery for retinopathy of prematurity -- 20 Surgery for intraocular tumors -- 21 Vitrectomy technology and techniques.
  • 2009 Thieme Book
    Tabandeh, Homayoun; Goldberg, Morton F.
    Retina in Systemic Disease: A Color Manual of Ophthalmoscopy is a practical reference for using ophthalmoscopy to recognize the retinal manifestations of systemic diseases and to confidently develop a diagnosis on the basis of such findings. Divided into three main sections, the book opens with a discussion of anatomy and the normal fundus and then provides straightforward, step-by-step instructions of examination techniques with valuable pearls on how to optimize the visualization of the retina. Numerous chapters in the second section of the book present the major clinical signs in the retina with concise lists of conditions associated with each sign. The third section provides comprehensive coverage of various systemic disorders, enabling the clinician to rapidly locate information useful for diagnosis, staging, and treatment. Each chapter in this section provides a brief description of the disorder, fundus features, additional ophthalmic features, and where appropriate, management techniques and differential diagnosis.
  • v.1-3, 2013 ClinicalKey
    Ryan, Stephen J.
    Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
  • v. 1-3, 2006.
    Ryan, Stephen J.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1. Basic science, inherited retinal disease, and tumors -- v. 2. Medical retina -- v. 3. Surgical retina.
  • 2008 Springer
    Penn, J. S.
    1. Cellular and molecular mechanisms of retinal angiogenesis / M.A. Behzadian et. al -- 2. Animal models of choroidal neovascularization / M.L. Clark, J.A. Fowler, and J.S. Penn -- 3. Rodent models of oxygen-induced retinopathy / S.E. Yanni, G.W. McCollum, and J.S. Penn -- 4. Animal models of diabetic retinopathy / T.S. Kern -- 5. Neovascularization in models of branch retinal vein occlusion / R.P. Danis and D.P. Bingaman -- 6. Vasculogenesis and angiogenesis in formation of the human retinal vasculature / T. Chan-Ling -- 7. IGF-1 and retinopathy / L.E.H. Smith -- 8. Hypoxia and retinal neovascularization / B.A. Berkowitz -- 9. Hypoxia inducible Factor-1 and VEGF induction / A. Madan -- 10. The role of protein kinase C in diabetic retinal vascular abnormalities / J.K. Sun and G.L. King -- 11. Eph receptor tyrosine kinases: modulators of angiogenesis / J. Chen, D. Brantley-Siders, and J.S. Penn -- 12. Adenosine in retinal vasculogenesis and angiogenesis in oxygen-induced retinopathy / G.A. Lutty and D.S. McLeod -- 13. The regulation of retinal angiogenesis by cyclooxygenase and the prostanoids / G.W. McCollum and J.S. Penn -- 14. Extracellular proteinases in ocular angiogenesis / A. Das and P.G. McGuire -- 15. Oxygen-independent angiogenic stimuli / J.M. Holmes, D.A. Leske, and W.L. Lanier -- 16. Growth factor synergy in angiogenesis / A.V. Ljubimov -- 17. Pigment epithelium derived factor and angiogenesis / J. Amaral and S.P. Becerra -- 18. Circulating endothelial progenitor cells and adult vasculogenesis / S. Caballero, N. Sengupta, L.C. Shaw, and M.B. Grant -- 19. Retinopathy of prematurity / D.L. Phelps -- 20. Angiogenesis in sickle cell retinopathy / G.A. Lutty and D.S. McLeod -- 21. Diabetic retinopathy / R.N. Frank -- 22. Systems for drug delivery to the posterior segment of the eye / A.L. Weiner and D.A. Marsh -- 23. Novel therapeutic strategies for posterior segment neovascularization / D.P. Bingaman, X. Gu, A.M. Timmers, and A. Davis -- 24. Choroidal neovascularization in age-related macular degeneration- from mice to man / L. Berglin.
  • 2013 Springer
    Arevalo, J. Fernando.
    This book presents the current information on retinal and choroidal manifestations of systemic diseases from leading experts in the field and is intended for ophthalmologists, retina specialists, uveitis and ocular oncology specialists. The topics discussed in this book are not all inclusive, but include retinal and choroidal manifestations of AIDS, diffuse unilateral subacute neuroretinitis (DUSN), posterior pole manifestations of cycticercosis, toxocariasis, tuberculosis, toxoplasmosis, viral diseases, fungal diseases, endogenous endophthalmitis, sarcoidosis, diabetic retinopathy, and many more.
  • 2010 ClinicalKey
    Yannuzzi, Lawrence A.
    Over 5,000 illustrations of the latest imaging and research findings essential for effective diagnosis of retinal disorders populate this atlas. A unique page layout consisting of optimally positioned panoramic images, magnified photos, and histopathological specimens illustrate key manifestations, giving you the best visual display of each disease. In addition, composite images using different retinal imaging modalities, including the latest in optical coherence tomography (OCT), fluorescein angiography, indocyanine green (ICG), and fundus autofluorescence display how a disease appears in each imaging modality, allowing you to compare imaging methods and gain a better understanding of each disorder.
  • 2007 Springer
    Barnstable, Colin J.; Tombran-Tink, Joyce.
    Coping with retinal degeneration : a patient's view / Gordon Cousins and James Cape -- Epidemiology of age-related macular degeneration early in the 21st century / Jie Jin Wang, Paul Mitchell, and Ronald Klein -- Leber congenital amaurosis : a hereditary childhood form of blindness and a model to elucidate retinal physiology and development / Robert K. Koenekoop -- Macular degeneration : aging changes and novel therapies / Peter E. Liggett and Alejandro J. Lavaque -- Stargardt disease : from gene discovery to therapy / Rando Allikmets -- X-linked juvenile retinoschisis / Bernhard H. F. Weber and Ulrich Kellner -- Retinal degeneration in Usher syndrome / David S. Williams -- Mouse models of retinitis pigmentosa / Bo Chang ... [et al.] -- The impact of diabetes on neuronal, glial, and vascular cells of the retina : implications for the pathogenesis of diabetic retinopathy / Sylvia B. Smith -- Statins and age-related maculopathy / Gerald McGwin, Jr. and Cynthia Owsley -- The role of drusen in macular degeneration and new methods of quantification / R. Theodore Smith and Umer F. Ahmad -- RPE lipofuscin : formation, properites, and relevance to retinal degeneration / Janet R. Sparrow -- Genetic modifiers that affect phenotypic expression of retinal diseases / Malia M. Edwards ... [et al.] -- X-linked retinal dystrophies and microtubular functions within the retina / Alan F. Wright and Xinhua Shu -- Synaptic remodeling in retinal degeneration / You-Wei Peng and Fulton Wong -- On the suppression of photoreceptor cell death in retinitis pigmentosa / Fiona Kernan ... [et al.] -- Cell-based therapies to restrict the progress of photoreceptor degeneration / Raymond D. Lund and Shaomei Wang -- Current status of IPE transplantation and its potential as a cell-based therapy for age-related macular degeneration and retinal dystrophies / Makoto Tamai -- Recent results in retinal transplantation give hope for restoring vision / Robert B. Aramant, Norman D. Radtke, and Magdalene J. Seiler -- Stem cells and retinal transplantation / Joanne Yau ... [et al.] -- Application of encapsulated cell technology for retinal degenerative diseases / Weng Tao and Rong Wen -- Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leber's congenital amaurosis / Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger -- The use of neuroprotective factors in retinal degenerations / Joyce Tombran-Tink and Colin J. Barnstable -- Carbonic anhydrase inhibitors as a possible therapy for RP17, an autosomal dominant retinitis pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response / George Rebello, Jacquie Greenberg, and Raj Ramesar -- Macular Degeneration- an addendum / Joyce Tombran-Tink and Colin J. Barnstable.
    Also available: Print – 2007
  • 2012 Springer
    Anderson, Robert E.; Ash, John D.; Grimm, Christian; Hollyfield, Joe G.; LaVail, Matthew M.
    Part 1. AMD: Basic Mechanisms, Inflammation and Immunity -- Part 2. Neuroprotection, Drugs and Novel Protective Therapies -- Part 3. Gene Therapy -- Part 4. Blood Vessels, Angiogenesis, and Neovascularization -- Part 5. Genotype/Phenotype -- Part 6. New Animal Models of Retinal Degeneration -- Part 7. Analysis of Retinal Degeneration by Imaging and Functional Testing -- Part 8. Mechanisms of Retinal Degeneration -- Part 9. Retinal Development, Physiology, Cell and Molecular Biology.
    Also available: Print – 2012
  • 2006 Springer
    Anderson, Robert E.; Hollyfield, Joe G.; LaVail, Matthew M.
    Molecular genetics and candidate genes -- Diagnostic, clinical, cytopathological, and physiologic aspects of retinal degeneration -- Animal models of retinal degeneration -- Gene therapy and neuroprotection -- Usher syndrome -- Stem cells, transplantation, and retinal repair -- Induced retinal degenerations.
    Also available: Print – 2006
  • 2010 Springer
    Anderson, Robert E.; Hollyfield, Joe G.; LaVail, Matthew M.
    Also available: Print – 2010
  • 2016 Springer
    Anderson, Robert E.; Ash, John D.; Grimm, Christian; Hollyfield, Joe G.; LaVail, Matthew M.; Rickman, Catherine Bowes.
    Also available: Print – 2016
  • 2014 Springer
    Anderson, Robert E.; Ash, John D.; Grimm, Christian; Hollyfield, Joe G.; LaVail, Matthew M.; Rickman, Catherine Bowes.
    "This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy."--Publisher's website.
    Also available: Print – 2014
  • 2006
    Huang, David.
    PrintStatus: Not Checked OutLane Catalog Record
    Sect. I Imaging modalities: basic principles and interpretation -- Sect. II Macular diseases -- Sect. III Retinal vascular diseases -- Sect. IV Inflammatory and infectious diseases -- Sect. V Other retinal diseases -- Sect. VI Tumors -- Sect. VII Optic nerve disorders.
  • 2016 Karger
    Do, Diana V.; Farah, Michel Eid; Mieler, William F.; Nguyen, Quan Dong; Rodrigues, Eduardo Büchele.
  • 2007 Springer
    Joussen, A. M.
    I. Pathogenesis of retinal vascular disease -- 1 Functional anatomy, fine structure and basic pathology -- 2 Retinal vascular development -- 3 Retinal angiogenesis and growth factors -- 4 Hematopoietic stem cells in vascular development and ocular neovascularization -- 5 Inflammation as a stimulus for vascular leakage and proliferation -- 6 The neuronal influence on retinal vascular pathology -- 7 Hypoxia in the pathogenesis of retinal disease -- 8 Blood retinal barrier -- 9 Retinal blood flow -- 10 Genetic approach to retinal vascular disease -- II. General concepts in the diagnosis and treatment of retinal vascular disease -- 11 A practical guide to fluorescein angiography -- 12 Optical coherence tomography in the diagnosis of retinal vascular disease -- 13 General concepts in laser treatment for retinal vascular disease -- 14 The role of photodynamic therapy in retinal vascular disease -- 15 Cryosurgery in retinal vascular disease -- 16 Vitrectomy in retinal vascular disease: surgical principles -- 17 Treatment of rubeotic secondary glaucoma -- 18 Intravitreal injections: guidelines to minimize the risk of endophthalmitis -- III. Pathology, clinical course and treatment of retinal vascular diseases -- 19 Grading of diabetic retinopathy -- 20 Retinopathy of prematurity -- 21 Vascular occlusive disease -- 22 Vascular abnormalities -- 23 Vasculopathy after treatment of choroidal melanoma -- 24 Vasculopathies with acute systemic diseases -- 25 Inflammatory vascular disease -- 26 Hypertensive retinopathies -- 27 Sickle cell retinopathy and hemoglobinopathies -- 28 Vascular tumors of the retina.
    Also available: Print – 2007
  • 2012 Springer
    Browning, David J.
    Anatomy and Pathologic Anatomy of Retinal Vein Occlusions -- Pathophysiology of Retinal Vein Occlusions -- Genetics of Retinal Vein Occlusions -- Classification of Retinal Vein Occlusion -- Epidemiology of Retinal Vein Occlusions -- Systemic and Ocular Associations of Retinal Vein Occlusions -- The Clinical Picture and Natural History of Retinal Vein Occlusions -- Ancillary Testing in the Management of Retinal Vein Occlusions -- Ischemia and Retinal Vein Occlusions -- Posterior Segment Neovascularization in Retinal Vein Occlusion -- Anterior Segment Neovascularization in Retinal Vein Occlusion -- Macular Edema in Retinal Vein Occlusion -- Treatment of Retinal Vein Occlusions -- Retinal Vein Occlusions in the Young -- Failed and Unadopted Treatments for Retinal Vein Occlusions -- Case Studies in Retinal Vein Occlusion.
  • 2010 Springer
    Rodríguez-Gallego, Carlos; Wilson, Matthew W.
  • 2013 Future Med
    Murray, Timothy G.
    Clinical advances and emerging treatment strategies / Timothy G. Murray -- Laboratory discoveries in retinoblastoma / Samuel K. Houston & Timothy G. Murray -- Incidence, prevalence and epidemiology / Ricardo Garza & Dan S. Gombos -- Clinical features and diagnosis of retinoblastoma / Matthew A. Cunningham & H. Culver Boldt -- Genetics of retinoblastoma and genetic counseling / Jessica Moline & Arun D. Singh -- Anesthetic considerations for children with retinoblastoma / Jacqueline Tutiven & Michael M. Vigoda -- Radiation therapy in retinoblastoma / Shiv C. Desai, Derek M. Isrow & Arnold M. Markoe -- Chemotherapy in the management of retinoblastoma / Ziad A. Khatib & Wenliang Geng -- Retinoblastoma treatment / Samuel K. Houston & Timothy G. Murray -- Treatment of extraocular and metastatic retinoblastoma / Ira J. Dunkel & Guillermo L. Chantada -- Second malignancies and other long-term effects in retinoblastoma survivors / Annette C. Moll, Jennifer van Dijk, Machteld I. Bosscha, Charlotte J. Dommering, Pim de Graaf, W. Arjenne Kors & Flora E. van Leeuwen -- Visual rehabilitation for retinoblastoma / D/ Wilkin Parke & Aaron Gold -- Retinoblastoma in the developing world / Vikas Khetan, Sabyasachi Sengupta, Fariooz P. Manjandavida & Santosh G. Honavar -- Index.
  • 2011
    Leong, Hwei Xian; Butcher, Eugene C.; Contag, Christopher H.; Engleman, Edgar G.; Negrin, Robert S.
    In the Adenomatous Polyposis Coli Multiple intestinal neoplasia (APCMin/+) mouse model of Familial Adenomatous Polyposis (FAP), T helper 17 (Th17) cells mediate tumor-promoting intestinal inflammation, but the underlying cause of inflammation is unknown. We find that in contrast to wild type lamina propria dendritic cells (LPDCs), which maintain intestinal tolerance by inducing TReg formation, APCMin/+ LPDCs instead induce Th17 formation. The reprogramming of LPDCs is due to a local deficit of the vitamin A metabolite, retinoic acid (RA), which results from insufficient synthesis and excessive breakdown of RA by gut associated Raldh and CYP enzymes, respectively. Exposure of APCMin/+ LPDCs to RA in vitro neutralizes their inflammatory phenotype. Treatment of mice with Liarozole, a CYP inhibitor, restores intestinal RA, eliminates Th17 inflammation and markedly reduces adenoma formation, whereas a vitamin A-deficient diet exacerbates disease. Elevated IL-17 and dysregulated vitamin A metabolism were also observed in FAP adenomas, suggesting that the same mechanism responsible for tumor-promoting intestinal inflammation in APCMin/+ mice applies to humans.
  • ScienceDirect
    Packer, Lester.
    Also available: Print – 1990
  • 1990 ScienceDirect
    Packer, Lester.
    Also available: Print – 1990
  • 2011 Springer
    Joseph, Jean V.; Patel, Hitendra R. H.
    Anatomical Aspects of the Extra- and Retroperitoneal Space / Ahmed E. Ghazi and Jean V. Joseph -- Essential Instruments in Laparoscopic and Robotic Surgery / Ty T. Higuchi and Matthew T. Gettman -- Upper Tract Retroperitoneal Access Techniques / Ahmed E. Ghazi and Jean V. Joseph -- Laparoscopic and Robotic Adrenalectomy / Edmund Y. Ko, Richard T. Schlinkert and Mitchell R. Humphreys -- Retroperitoneoscopic Simple and Radical Nephrectomy / Guillaume Ploussard, Andras Hoznek, Laurent Salomon, Claude C. Abbou and Alexandre de la Taille -- Laparoscopic and Robotic Partial Nephrectomy / Lori M. Dulabon and Michael D. Stifelman -- Retroperitoneal Robotic Partial Nephrectomy / James R. Porter -- Laparoscopic and Robotic Mid and Distal Ureteral Reconstructive Surgery / Alireza Moinzadeh -- Robot-Assisted Laparoscopic Nephroureterectomy / Sijo J. Parekattil, Hany N. Atalah and Li-Ming Su -- Laparoscopic Pelvic Lymphadenectomy in Prostate Cancer / Evangelos Liatsikos, Minh Do, Panagiotis Kallidonis, Iason Kyriazis and Alan McNeil, et al. -- Laparoscopic Simple Prostatectomy / Xavier Cathelineau, Rafael E. Sanchez-Salas, Eric Barret, Francois Rozet and Marc Galiano, et al. -- Extraperitoneal Laparoscopic Radical Prostatectomy / Sarah P. Psutka and Douglas M. Dahl -- Robot-Assisted Extraperitoneal Laparoscopic Prostatectomy / Thomas T. Hoang, Satya B. Allaparthi and Ingolf A. Tuerk -- Laparoendoscopic Single-Site Retroperitoneal Surgery / Michael A. White and Jihad H. Kaouk -- On the Horizon / Jean V. Joseph and Hitendra R. H. Patel.
  • 2008 Springer
    Christen, Yves; Gage, F.
  • 2013
    Chuong, Edward Bo-yi; Baker, Julie C.; Bustamante, Carlos; Sherlock, Gavin; Sidow, Arend.
    The placenta plays a fundamental role supporting pregnancy in all mammals, but exhibits unexpected and striking morphological and physiological variation across species. The rapid evolutionary diversification of the mammalian placenta is hypothesized to be a product of recurrent genetic conflict between parent and offspring. In this work, I investigate the genetic basis of rapid placenta evolution by using high-throughput genomic approaches, and address three major issues in placental biology. First, given that highly conserved genes govern placental development, the molecular mechanisms underlying the rapid diversification of placental morphology have remained unresolved. Our study reveals that the genome-wide regulatory landscape of placental development is highly divergent between closely related species, strongly implicating non-coding regulatory evolution as the major force driving placental morphological diversity. Second, endogenous retroviruses (ERVs) that are normally repressed throughout the embryo are rampantly expressed in the placenta, but the biological rationale--if any-- behind this apparent paradox has been unclear. We demonstrate that species-specific ERVs serve as a major source of functional enhancers during placental development, which provides a clear mechanism where placental ERV activity may facilitate the evolutionary diversification of placental morphology. Finally, our findings suggest a novel evolutionary model where placental ERVs provide an adaptive benefit under parent-offspring conflict. Given that genetic conflict predicts rapid diversifying evolution to maintain maximal fitness, we propose that placental ERVs act to dramatically increase the developmental evolvability of the placenta by serving as a rapidly evolving, epigenetically restricted source of polymorphic regulatory elements.
  • ScienceDirect
    Kuo, Lawrence C.; Shafer, Jules A.
    Also available: Print – 1994
  • 2011 Springer
    Dudley, Jaquelin.
    Chapter 1: Overview of Retrovirology -- Chapter 2: Mechanisms of Oncogenesis by Retroviruses -- Chapter 3: Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses -- Chapter 4: Genetics of Host Resistance to Retroviruses and Cancer -- Chapter 5: Endogenous Retroviruses and Cancer -- Chapter 6: Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer -- Chapter 7: Cancers Induced by Piscine Retroviruses -- Chapter 8: The Immune Response to Oncogenic Retroviruses -- Chapter 9: Retrovirus-induced Immunodeficiency and Cancer.
  • 2006 Springer
    Ogden, Richard C.; Skowron, Gail.
    Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren -- Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler -- Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens -- Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels -- Nucleotide analogs / Craig J. Hoesley -- Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters -- Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard ... [et al.] -- Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt -- Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis -- Mitochondrial toxicity and lipodystrophy / Grace McComsey -- Nevirapine / David Asmuth and Richard Pollard -- Efavirenz / Graeme J. Moyle and Brian Conway -- Delavirdine / Brian Conway -- Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich -- Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha -- New reverse transcriptase inhibitors in development / Rudi Pauwels -- Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande.
  • 2010 CRCnetBASE
    Rea, William J.; Patel, Kalpana.
    Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.
  • 2015 CRCnetBASE
    Rea, William J.; Patel, Kalpana.
  • 2010
    Gallardo, Andre; Berry, Valerie.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    Bhatt, Nandan; Ibsen, Kenneth.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007
    Rosner, Mitchell H.; Lazar, Andrew E.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2010
    Rosner, Mitchell H.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2006
    Lazo, John S.; Glorioso, Joseph C.; Pitt, Bruce R.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2015 Springer
    Amestoy, William.
  • 2014 (13th ed.) AccessMedicine
    12th ed., 2012 AccessMedicine
    Levinson, Warren.
    Also available: Print – 2006-<2014>
  • 2012 (24th ed.) AccessMedicine
    Barrett, Kim E.; Ganong, William F.
    Also available: Print – 1985-<2016>
  • 2013 Ovid
    Brinker, Mark R.
  • 2012 ClinicalKey
    Miller, Mark D.
    "At all levels of orthopaedic training and practice, Review of Orthopaedics , by Mark D. Miller, MD, is an ideal, state-of-the-art resource for efficient review of key orthopaedic knowledge and board prep. Thoroughly updated, this edition helps you ensure your mastery of the very latest scientific and clinical information."--Publisher's website.
  • 2008
    Hart, Jennifer A.; Miller, Mark D.
    Basic sciences / Mark R. Brinker, Daniel P. O'Connor -- Pediatric orthopaedics / Todd A. Milbrandt, Daniel J. Sucato -- Sports medicine / Joshua A. Baumfeld, Jennifer A. Hart, Mark D. Miller -- Adult reconstruction / Edward J. McPherson -- Disorders of the foot and ankle / Gregory J. Roehrig, MD ... [et al.] -- Hand, upper extremity, and microvascular / Lance M. Brunton, A. Bobby Chhabra -- Spine / William C. Lauerman, Bradley Graw -- Pathology / Frank J. Frassica, Deborah A. Frassica, Edward F. McCarthy -- Rehabilitation: gait, amputations, prosthetics, orthotics / Frank A. Gottschalk -- Trauma / James P. Stannard ... [et al.] -- Anatomy / Franklin D. Shuler -- Principles of practice and statistics / S. Raymond Golish, Mark DeHart.
  • 2012 Ovid
    Huda, Walter.
    X-ray production -- X-ray interactions -- Projection radiography I -- Projection radiography II -- Computed tomography -- Image quality -- Radiobiology/patient dosimetry -- Radiation protection -- Nuclear medicine -- Ultrasound -- Magnetic resonance.
    Also available: Print – 2010
  • 1967
    Young, Marjorie A. C.
    [1] What people know, believe, and do about health. -- [4] Patient education. -- [6] School health education.
  • 2012 Springer
    Colburn, Nona T.
    The Musculoskeletal System -- Mediators of Rheumatic Pathology -- Immunity -- Genetics -- Rheumatoid Arthritis -- Psoriatic Arthritis -- Systemic Lupus Erythematosus (SLE) -- Arthritis Associated with Calcium-Containing Crystals -- Gout -- Vasculitides -- Systemic Sclerosis and Related Syndromes -- Sjögren's Syndrome -- Behcet's Disease -- Relapsing Polychondritis -- Antiphospholipid Syndrome -- Adult Still's Disease -- Therapeutic Injections for Rheumatic Diseases -- Nonsteroidal Anti-inflammatory Drugs -- Corticosteroids -- Disease-Modifying Antirheumatic Drugs -- Cytotoxic and Immunoregulatory Agents -- Biologic Agents -- Osteoporosis -- Metabolic Bone Disorders -- Paget's Disease of Bone -- Osteonecrosis -- Hypertrophic Osteoarthropathy -- Storage and Deposition Diseases -- Amyloidoses -- The Autoinflammatory Diseases.
  • 2006 Springer
    Cathey, Lamont; Greene, Frederick L.; Mostafa, Gamal.
  • NAP
    Kalsbeek, William D.; Wunderlich, Gooloo S.
  • NAP
  • 2005 NAP
  • Rand
    Hilborne, Lee H.; Golomb, Beatrice Alexandra.
    v. 1. Infectious diseases.
  • NAP
  • 2015 Ovid
    Chern, Kenneth C.; Saidel, Michael.
    Fundamentals / Michael A. Saidel, Ashley Rohr -- Embryology and anatomy / Megan E. Collins -- Optics / Kenneth Chern -- Neuro-ophthalmology / Jeffrey Nichols -- Pediatrics and strabismus / Megan E. Collins -- Plastics / Marcus J. Ko, Wendy W. Lee -- Pathology / Marcus Marcet -- Uveitis / David M. Hinkle -- Glaucoma / Shuchi Patel -- Cornea / Kenneth Chern and Michael Saidel -- Lens/cataract / Kenneth Chern and Edward Koo -- Retina and vitreous / Alok Bansal, Rahul Khurana and Louis Chang.
  • 2006 Springer
    Buerstedde, Jean-Marie; Takeda, Shunichi.
    Ch. 1. DT40 gene disruptions: a how-to for the design and the construction of targeting vectors / Hiroshi Arakawa and Jean-Marie Buerstedde -- Ch. 2. Immunoglobulin gene conversion or hypermutation: That's the question / Jean-Marie Buerstedde and Hiroshi Arakawa -- Ch. 3. Genome resources for the DT40 community / Randolph B Caldwell and Andrzej M. Kierzek -- Ch. 4. Chromosome engineering in DT40 cells and mammalian centromere function / William R.A. Brown ... [et al.] -- Ch. 5. Function of recQ family helicase in genome stability / Masayuki Seki, Shusuke Tada and Takemi Enomoto -- Ch. 6. Genetic analysis of apoptotic execution / Sandrine Ruchaud ... [et al.] -- Ch. 7. The DT40 system as a tool for analyzing kinetochore assembly / Masahiro Okada, Tesuya Hori and Tatsuo Fukagawa -- Ch. 8. Analysing the DNA damage and replication checkpoints in DT40 cells / Michael D Rainey, George Zachos, and David AF Gillespie -- Ch. 9. Using DT40 to study clathrin function / Frank R. Wettey and Antony P. Jackson -- Ch. 10. Genetic analysis OF B cell signaling / Hisaaki Shinohara and Tomohiro Kurosaki -- Ch. 11. DT40 mutants: a model to study transcriptional regulation of B cell development and function / Jukka Alinikula, Olli Lassila and Kalle-Pekka Nera -- Ch. 12. Transcription and RNA processing factors play complex roles IN DT40 cells / Stephanie Bush and James L. Manley -- Ch. 13. Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions / Hidehiko Kikuchi ... [et al.] -- Ch. 14. Analysis of gene expression, copy number and palindrome formation with a DT40 enriched cDNA Microarray / Paul E. Neima ... [et al.] -- Ch. 15. Analysis of DNA replication damage bypass and its role in immunoglobulin repertoire development / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 16. The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 17. Calcium signaling, ion channels and more / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- Ch. 18. Phenotypic analysis of cellular responses to DNA damage / Helfrid Hochegger and Shunichu Takeda -- Ch. 19. ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells / Ken-ichi Yamamoto, Masahiko Kobayashi and Hiroko Shimizu -- METHOD 1. Stable transfection of DT40 / Julian E. Sale -- METHOD 2. Basic cell culture conditions / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 3. Excision of floxed-DNA sequences by transient induction of Mer-Cre-Mer / Hiroshi Arakawa -- METHOD 4. Immunoglobulin gene conversion and hypermutation assay by FACS / Hiroshi Arakawa -- METHOD 5. Target screening by PCR / Hiroshi Arakawa -- METHOD 6. Mitotic index determination by flow cytometry / David AF Gillespie and Mark Walker -- METHOD 7. Centrifugal elutriation as a means of cell cycle phase separation and synchronization / David AF Gillespie and Catarina Henriques -- METHOD 8. Preparation of genomic DNA for microarray-based comparative genome hybridization / Robert Kimmel, Amalia Icreverzi, Paul Neiman -- METHOD 9. Analysis of cellular Mg2+ in DT40 cells / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- METHOD 10. Transient transfection of DT40 / Roger Franklin & Julian E. Sale -- METHOD 11. Retroviral transduction of DT40 / Felix Randow & Julian E. Sale -- METHOD 12. Colony survival assay / Laura. J. Simpson & Julian E. Sale -- METHOD 13. Subcloning DT40 by limiting dilution / Jean-Marie Buerstedde -- METHOD 14. Subnuclear immunofluorescence / Dávid Szüts & Julian E. Sale -- METHOD 15. Sister chromatid exchange assay / Laura J. Simpson & Julian E. Sale -- METHOD 16. 2D cell cycle analysis / Roger Franklin & Julian E. Sale -- METHOD 17. Purification of tap-tagged proteins by two-step pull down from DT40 cells / Hiroyuki Kitao and Minoru Takata -- METHOD 18. Synchronization of cells / Eiichiro Sonoda -- METHOD 19. Tranfection of DT40 cells / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 20. Luciferase reporter assay / Frank R. Wettey and Antony P. Jackson -- METHOD 21. Indirect immunofluorescence microscopy / Frank R. Wettey and Antony P. Jackson -- METHOD 22. Quantification of receptor-mediated endocytosis / Frank R. Wettey and Antony P. Jackson -- METHOD 23. Measurement of DNA synthesis and strand breaks using alkaline sucrose density gradient centrifugation / Kouichi Yamada and Jun Takezawa -- METHOD 24. Fractionation of nuclear and cytoplasmic proteins from DT40 cell lines / Yan-Dong Wang and Randolph B Caldwell.
  • 2012 Springer
    Geddes, Chris D.
  • 2010 Springer
    Geddes, Chris D.
  • Hirons, Jean L.; Kuhagen, Judith A.; Reynolds, Regina.
  • 2014 Springer
    Marx, Robert.
    Although anterior cruciate ligament (ACL) reconstruction has a high success rate, a substantial number of patients are left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique provides detailed strategies for planning and executing revision ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons cover the diagnosis of failed ACL reconstruction, patient evaluation, preoperative planning for revision ACL surgery, and complex technical considerations.
  • 2007 Springer
    Le Béguec, Pierre; Sieber, Hans-Peter.
  • 2005 Springer
    Bono, James V.; Scott, Richard D.
  • 2014 Cambridge
    Cummings, Constance A.; Kirmayer, Laurence J.; Lemelson, Robert.
  • 1977-
    Schneider, Daniel E.
    PrintStatus: Not Checked OutLane Catalog Record
  • 1976-
    Wilbur, C. Keith.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013
    This report is being released in conjunction with the Robert Wood Johnson Foundation's Care About Your Care initiative, which is devoted to improving care transitions when people leave the hospital. It looks at the issue of readmissions in two ways: by the numbers and through the eyes of the people who live them.
  • Paxinos, George.
  • 2009 NICE
    The summary of the published clinical guideline on Rheumatoid arthritis. It links to the published guidance and key documents.
  • 2012 Springer
    Ebringer, A.
  • 2009 ClinicalKey
    Hochberg, Marc C.
    This reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It provides the latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures-disease activity, joint assessment, imaging, and more-for expert diagnosis and monitoring of disease progression.
  • 2011 Springer
    Benenson, E. V.
    1. Diagnostic Training and Rheumatology Trees -- 2. Explanations of Figures and Case Reports with Individual Therapeutic Options -- 3. Index of Figures (Fig.) and CS with Syndromes (for Self-assessment) -- Appendix: Index of the Solutions to the Syndromes and Diagnostics (for Rapid Diagnosis).
  • 2010 Springer
    Silva, J. A. P. da; Woolf, Anthony D.
    The Importance of Rheumatic Diseases, The Satisfaction Of Caring For These Patients -- Pain, Disease and Suffering an Integrated Perspective -- The Structure and Function of the Musculoskeletal System Sources of Pain -- Diagnostic Strategy the Main Syndromes in Rheumatology -- The Standard Enquiry in Rheumatology -- The General Clinical Examination -- Regional Syndromes Neck Pain -- Regional Syndromes The Painful Shoulder -- Regional Syndromes The Elbow And Forearm -- Regional Syndromes the Wrist and Hand -- Regional Syndromes Low Back Pain -- Regional Syndromes The Hip -- Regional Syndromes The Knee -- Regional Syndromes the Foot and Ankle -- Generalized Pain Syndrome Fibromyalgia Osteoarthritis -- Inflammatory Arthritides Diagnostic Strategies -- Monoarthritis -- Chronic, Additive, Symmetrical, Peripheral Polyarthritis -- Chronic, Asymmetrical Oligo- Or Polyarthritis -- Chronic Proximal Oligoarthritis -- Arthritis of the Shoulder and Pelvic Girdles Polymyalgia Rheumatica -- Acute Oligo- or Polyarthritis Febrile Arthritis Arthritis with Mucocutaneous Manifestations -- Inflammatory Low Back Pain -- Systemic Syndromes Connective Tissue Diseases Vasculitis Raynaud's Phenomenon -- Osteoporotic Syndrome Osteoporosis -- Bone Syndrome Bone Diseases -- Rheumatic Symptoms in Children and Adolescents -- Treating Rheumatic Diseases, General Principles -- Drugs Commonly Used in Rheumatic Diseases.
  • 2015 ClinicalKey
    Hochberg, Marc C.; Silman, Alan J.; Smolen, Josef S.; Weinblatt, Michael E.; Weisman, Michael H.
    Stay current in the ever-changing discipline of rheumatology with clear, reliable guidance from Hochberg's Rheumatology, one of the most respected and trusted sources in the field. Designed to meet the needs of the practicing clinician, this medical reference book provides extensive, authoritative coverage of rheumatic diseases from basic scientific principles to practical points of clinical management in a lucid, logical, user-friendly manner. Track disease progression and treat patients more effectively with the information on genetic findings, imaging outcomes, cell and biologic therapies, rheumatoid arthritis, and SLE. Incorporate recent findings about pathogenesis of disease; imaging outcomes for specific diseases like RA, osteoarthritis, and spondyloarthropathies; cell and biologic therapies; and other timely topics.
  • 2011 Springer
    Benenson, E. V.
    1. Articular disorders -- 2. Diseases of the spine -- 3. Soft-tissue rheumatism and related disorders -- 4. Regional arthrological and musculoskeletal syndromes -- 5. Paraneoplastic syndromes (PNS) in rheumatology -- 6. Algorithms in articular and musculoskeletal disorders: integrated diagnostic screening program: staged diagnostics -- 7. Algorithms in arthrological and musculoskeletal disorders -- 8. General symptoms (BVAS = maximum of 3 out of 63 points) -- 9. Involvement of connective tissue structures -- 10. System-/organ involvement -- 11. (Auto) immunological phenomena and serological diagnostics -- 12. Treatment-induced and associated conditions and diseases -- 13. Integrated diagnostic screening program staged diagnostics -- 14. Algorithms for connective tissue disease and vasculitis.
  • NGC
  • 2007 Springer
    Kountakis, Stilianos E.; Önerci, Metin.
  • 2009 Springer
    Stucker, Frederick J.
  • 2012 ClinicalKey
    Guyuron, Bahman.
    Surgical Anatomy and Physiology of the Nose -- Patient Assessment for Rhinoplasty -- Dynamics of Rhinoplasty -- Primary Rhinoplasty -- Variations in Nasal Osteotomy : Consequences and Technical Nuances -- Tip Sutures -- Achieving Optimal Tip Projection -- Elongation of the Short Nose -- Correction of the Overprojected Nose -- Rhinoplasty on Patients with Cleft Lip Nose Deformity -- Correction of Alar Rim Deformities -- Alar Base Surgery -- Controlling the Nostril Size -- Rhinoplasty and Time Element -- Correcting the Nasal Deformity Resulting from Cocaine Insufflation -- Rhinoplasty in Patients with Thick Skin -- Correcting Deviated Noses, Septoplasty and Turbinectomy -- Rhinoplasty and Ethnicity -- Secondary Rhinoplasty -- Prevention and Management of Rhinoplasty Complications -- Rhinogenic Migraine Headaches.
  • 2008 Springer
    Kennedy, David W.; Thaler, Erica R.
  • 2005 Springer
    Manser, Ed.
  • 2012 Springer Protocols
    Rivero-Crespo, Francisco.
    Historical overview of Rho GTPases -- Rho GTPases: Deciphering the evolutionary history of a complex protein family -- Biochemical assays to characterize Rho GTPases -- How to analyze bacterial toxins targeting Rho GTPases -- Assessing ubiquitylation of Rho GTPases in mammalian cells -- Posttranslational lipid modification of Rho family small GTPases -- Analysis of the role of RhoGDI1 and isoprenylation in the degradation of RhoGTPases -- A quantitative fluorometric approach for measuring the interaction of RhoGDI with membranes and Rho GTPases -- Rho GTPases and cancer cell transendothelial migration -- Quantitative and robust assay to measure cell-cell contact assembly and maintenance -- Rho GTPase knockout induction in primary keratinocytes from adult mice -- Rho GTPase techniques in osteoclastogenesis -- Assessment of Rho GTPase signaling during neurite outgrowth -- Assessment of the role for Rho family GTPases in nadph oxidase activation -- Multiplex imaging of Rho family GTPase activities in living cells -- FRET-based imaging of rac and cdc42 activation during fc-receptor-mediated phagocytosis in macrophages -- High-throughput flow cytometry bead-based multiplex assay for identification of Rho GTPase inhibitors -- Functional analysis of Rho GTPase activation and inhibition in a bead-based miniaturized format -- Use of phage display for the identification of molecular sensors specific for activated Rho -- Identification of new interacting partners for atypical Rho GTPases: A silac-based approach -- Using zebrafish for studying Rho GTPases signaling in vivo -- Analysis of Rho GTPase function in axon pathfinding using caenorhabditis elegans -- Protocol for ex vivo incubation of drosophila primary post-embryonic haemocytes for real-time analyses -- Analysis of Rho GTPase activation in saccharomyces cerevisiae -- Assaying Rho GTPase-dependent processes in dictyostelium discoideum -- FRAP-based analysis of Rho GTPase-dependent polar exocytosis in pollen tubes.
  • 2010 Springer
    Golen, Kenneth van.
  • Grzyb, Frank L.
    "During the Civil War, Union soldiers and Confederate prisoners convalesced in a general army hospital in Portsmouth Grove, Rhode Island. This study details experiences of those who received and provided care, exploring the barbarities of medicine, daily routine, role of citizens, later adventures of former patients/staff, and final resting places of those who died on the grounds"--Provided by publisher.
  • 2014 CRCnetBASE
    Ampong-Nyarko, Kwesi; Cuerrier, Alain.
    Chapter 1. Taxonomy of Rhodiola rosea L., with special attention to molecular analyses of Nunavik (Québec) populations / Alain Cuerrier, Mariannick Archambault, Michel Rapinski, and Anne Bruneau -- Chapter 2. Ethnobotany and conservation of Rhodiola species / Alain Cuerrier, Youri Tendland, and Michel Rapinski -- Chapter 3. Phytochemistry of Rhodiola rosea / Fida Ahmed, Vicky Filion, Ammar Saleem, and John T. Arnason -- Chapter 4. Cultivation of Rhodiola rosea in Europe / Bertalan Galambosi -- Chapter 5. Rhodiola rosea cultivation in Canada and Alaska / Kwesi Ampong-Nyarko -- Chapter 6. Diseases of wild and cultivated Rhodiola rosea / Sheau-Fang Hwang, Stephen E. Strelkov, Kwesi Ampong-Nyarko, and Ron J. Howard -- Chapter 7. Biotechnology of Rhodiola rosea / Zsuzsanna György -- Chapter 8. Pharmacological activities of Rhodiola rosea / Fida Ahmed, Steffany A.L. Bennett, and John T. Arnason -- Chapter 9. Evidence-based efficacy and effectiveness of Rhodiola SHR-5 extract in treating stress- and age- associated disorders / Alexander Panossian and Georg Wikman -- Chapter 10. Rhodiola rosea in psychiatric and medical practice / Patricia L. Gerbarg, Petra A. Illig, and Richard P. Brown -- Chapter 11. Toxicology and safety of Rhodiola rosea / Hugh Semple and Brandie Bugiak -- Chapter 12. Commercialization of Rhodiola rosea / Nav Sharma and Raimar Loebenberg.
  • 2015 Springer Protocols
    Jastrzebska, Beata.
    G protein-coupled receptor rhodopsin : a historical perspective / Lukas Hofmannand Krzysztof Palczewski -- Rhodopsin purification from dark-adapted bovine retina / Elise Blankenship and David T. Lodowski -- Mammalian expression, purification, and crystallization of rhodopsin variants / Daniel Mattle [and 4 others] -- Imaging of rhodopsin crystals with two-photon microscopy / Grazyna Palczewska and David Salom -- Functional stability of rhodopsin in a bicelle system : evaluating G protein activation by rhodopsin in bicelles / Ali I. Kaya, T.M. Iverson, and Heidi E. Hamm -- Rhodopsin-arrestin-1 interaction in bicelles / Qiuyan Chen [and 7 others] -- Detection of structural waters and their role in structural dynamics of rhodopsin activation / Liwen Wang and Mark R. Chance -- Probing conformational changes in rhodopsin using hydrogen-deuterium exchange coupled to mass spectrometry / Tivadar Orban and Yaroslav Tsybovsky -- Analysis of conformational changes in rhodopsin by histidine hydrogen-deuterium exchange / David T. Lodowski and Masaru Miyagi -- Investigation of rhodopsin dynamics in its signaling state by solid-state deuterium NMR spectroscopy / Andrey V. Struts [and 3 others] -- Sequential structural changes in rhodopsin occurring upon photoactivation / Naoki Kimata [and 4 others.] -- Dynamic single-molecule force spectroscopy of rhodopsin in native membranes / Paul S.-H. Park and Daniel J. Müller -- High-resolution atomic force microscopy imaging of Rhodopsin in rod outer segment disk membranes / Patrick D. Bosshart, Andreas Engel, and Dimitrios Fotiadis -- Detection of rhodopsin dimerization in situ by PIE-FCCS, a time-resolved fluorescence spectroscopy / Adam W. Smith -- Oligomeric state of rhodopsin within rhodopsin-transducin complex probed with succinylated concanavalin A / Beata Jastrzebska -- Quantification of arrestin-rhodopsin binding stoichiometry / Ciara C.M. Lally and Martha E. Sommer -- Rhodopsin transient complexes investigated by systems biology approaches / Daniele Dell'Orco -- Three-dimensional architecture of murine rod cilium revealed by cryo-EM / Theodore G. Wenseland Jared C. Gilliam -- Monitoring of rhodopsin trafficking and mistrafficking in live photoreceptors / Kerrie H. Lodowski and Yoshikazu Imanishi -- Measurements of rhodopsin diffusion within signaling membrane microcompartments in live photoreceptors / Mehdi Najafi and Peter D. Calvert -- Kinetics of rhodopsin's chromophore monitored in a single photoreceptor / Leopold Adler IV [and 3 others] -- Supplementation with vitamin A derivatives to rescue vision in animal models of degenerative retinal diseases / Lindsay Perusek, Akiko Maeda, and Tadao Maeda -- Sustained delivery of retinoids to prevent photoreceptor death / Peter H. Tang and Rosalie K. Crouch -- High-throughput screening assays to identify small molecules preventing photoreceptor degeneration caused by the rhodopsin P23H mutation / Yuanyuan Chen and Hong Tang -- Gene therapy to rescue retinal degeneration caused by mutations in rhodopsin / Brian P. Rossmiller, Renee C. Ryals, and Alfred S. Lewin.
  • 2006
    Buzsáki, G.
    PrintStatus: Not Checked OutLane Catalog Record
    Structure defines function -- Diversity of cortical functions is provided by inhibition -- Windows on the brain -- A system of rhythms -- Synchronization by oscillation -- The brain's default state -- Perturbation of the default patterns by experience -- The gamma buzz -- Perceptions and actions are brain state-dependent -- Oscillations in the "other cortex" -- Coupling of systems by oscillations -- Tough problems.
  • 2010 Springer
    Altman, Sidney; Liu, Fenyong.
    History of RNase P and Overview of Its Catalytic Activity -- The Evolution of RNase P and Its RNA -- Over a Decade of Bacterial Ribonuclease P Modeling -- Structural Studies of Ribonuclease P -- Folding of Bacterial RNase P RNA -- Kinetic Mechanism of Bacterial RNase P -- Roles of Metal Ions in RNase P Catalysis -- Challenges in RNase P Substrate Recognition: Considering the Biological Context -- Archaeal RNase P: A Mosaic of Its Bacterial and Eukaryal Relatives -- Eukaryote RNase P and RNase MRP -- RNase P from Organelles -- Human RNase P and Transcription -- RNase P as a Drug Target -- Ribonuclease P as a Tool.
  • 2011 Springer
    Nicholson, Allen W.
  • pt. A-B, 2001. ScienceDirect
    pt. B ScienceDirect
    Nicholson, Allen W.
    Also available: Print – pt. A-B, 2001.
  • 2012 Springer Protocols
    Douthwaite, Julie A.; Jackson, Ronald H.
    Ribosome display : a perspective / Andreas Plückthun -- Preparation and testing of E. coli S30 in vitro transcirption translation extracts / James F. Zawada -- Eurkaryotic ribosome display selection using rabbit reticulocyte lysate / Julie A Douthwaite -- Stabilized ribosome display for in vitro selection / Shuta Hara [and others] -- Eukaryotic ribosome display with in situ DNA recovery / Mingyue He [and others] -- mRNA display using covalent coupling of mRNA to translated proteins / Rong Wang, Steve W. Cotten, and Rihe Liu -- SNAP display : in vitro rotein evolution in microdroplets / Miriam Kaltenbach and Florian Hollfelder -- cDNA display : rapid stabilization of mRNA display / Shingo Ueno and Naoto Nemoto -- Optimisation of antibody affinity by ribosome display using error-prone or site-directed mutagenesis / Leeanne Lewis and Chris Lloyd -- Affinity maturation of phage display antibody populations using ribosome display / Maria A. Groves and Adrian A. Nickson -- Evolution of protein stability using ribosome display / Andrew Buchanan -- Selection of lead antibodies from naive ribosome display antibody libraries / Peter Ravn -- Evolution of disulfide-rich peptide aptamers using cDNA display / Yuki Mochizuki and Naoto Nemoto -- Peptide screening using PURE ribosome display / Hiroyuki Ohashi [and others] -- Rapid selection of high-affinity binders using ribosome display / Birgit Dreier and Andreas Plückthun -- mRNA display-based selections using synthetic peptide and natural protein libraries / Steve W. Cotten [and others] -- Identification of candidate vaccine genes using ribosome display / Liancheng Lei -- Ribosome display for the selection of Sac7d scaffolds / Barbara Mouratou [and others] -- Charging of tRNAs using ribozymes and selection of cyclic peptides containing thioethers / Patrick C. Reid [and others] -- Update on pure translation display with unnatural amino acid incorporation / R. Edward Watts and Anthony C. Forster -- In vitro selection of unnatural cyclic peptide libraries via mRNA display / Zhong Ma and Matthew C.T. Hartman -- Optimization of CAT-354, a therapeutic antibody directed against interleukin-13, using ribosome display / George Thom and Ralph Minter -- Affinity maturation and functional dissection of a humanised anti-RAGE monoclonal antibody by ribosome display / Simon E. Hufton.
  • ScienceDirect
    Moldave, Kivie; Noller, Harry F.
    Also available: Print – 1988
  • 2011 Springer
    Green, Rachel; Rodnina, Marina V.; Wintermeyer, Wolfgang.
    The ribosome is a macromolecular machine that synthesizes proteins with a high degree of speed and accuracy. Our present understanding of its structure, function and dynamics is the result of six decades of research. This book collects over 40 articles based on the talks presented at the 2010 Ribosome Meeting, held in Orvieto, Italy, covering all facets of the structure and function of the ribosome. New high-resolution crystal structures of functional ribosome complexes and cryo-EM structures of translating ribosomes are presented, while partial reactions of translation are examined in structural and mechanistic detail, featuring translocation as a most dynamic process. Mechanisms of initiation, both in bacterial and eukaryotic systems, translation termination, and novel details of the functions of the respective factors are described. Structure and interactions of the nascent peptide within, and emerging from, the ribosomal peptide exit tunnel are addressed in several articles. Structural and single-molecule studies reveal a picture of the ribosome exhibiting the energy landscape of a processive Brownian machine. The collection provides up-to-date reviews which will serve as a source of essential information for years to come.
  • 2014 ScienceDirect
    Burke, Donald H.
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in riboswitch discovery and validation, synthesis and sample prep methods for large RNAs, riboswitch structure and function methods, folding pathways and dynamics, and ligand interactions and thermodynamics.Continues the legacy of this premier serial with quality chapters authored by leaders in the fieldCovers research methods in biomineralization scienceContains sections on such topics as riboswitch discovery and valid.
  • 2015 ScienceDirect
    Burke, Donald H.
  • 2013 Springer Protocols
    Yang, Yinong.
    Rice artificial hybridization for genetic analysis / Xueyan Sha -- Fluorescence in situ hybridization techniques for cytogenetic and genomic analyses / Jason G. Walling, Wenli Zhang, and Jiming Jiang -- Generation of rice mutants by chemical mutagenesis / Thomas H. Tai -- TILLING and ecotilling for rice / Jennifer L. Cooper [and others] -- Functional characterization of rice genes using a gene-indexed T-DNA insertional mutant population / Ki-Hong Jung and Gynheung An -- QTL analysis and map-based cloning of salt tolerance gene in rice / Ji-Ping Gao and Hong-Xuan Lin -- Site-specific gene integration in rice / Vibha Srivastava -- Transcriptome profiling analysis using rice oligonucleotide microarrays / Ki-Hong Jung and Pamela C. Ronald -- Cloning of small RNAs for the discovery of novel microRNAs in plants / Guru Jagadeeswaran and Ramanjulu Sunkar -- Global identification of small RNA targets in plants by sequencing sliced ends of messenger RNAs / Yong-Fang Li and Ramanjulu Sunkar -- Artificial microRNAs for specific gene silencing in rice / Norman Warthmann [and others] -- Rice proteomic analysis : sample preparation for protein identification / Ganesh Kumar Agrawal [and others] -- Quantification of jasmonic and salicylic acids in rice seedling leaves / Kyoungwon Cho [and others] -- Analysis of insect-induced volatiles from rice / Nan Zhao [and others] -- Phenotypic and physiological evaluation for drought and salinity stress responses in rice / Utlwang Batlang [and others] -- Phenotypic, physiological, and molecular evaluation of rice chilling stress response at the vegetative stage / Benildo G. de los Reyes [and others] -- Analysis of rice root hair morphology using cryo-scanning electron microscopy / Zhiming Yu -- Inoculation and virulence assay for bacterial blight and bacterial leaf streak of rice / Bing Yang and Adam Bogdanove -- Inoculation and scoring methods for rice sheath blight disease / Yulin Jia [and others] -- Molecular approaches to improve rice abiotic stress tolerance / Junya Mizoi and Kazuko Yamaguchi-Shinozaki -- Molecular strategies to improve rice disease resistance / Emily E. Helliwell and Yinong Yang -- Molecular strategies to engineer transgenic rice seed compartments for large-scale production of plant-made pharmaceuticals / Trevor Greenham and Illimar Altosaar.
  • 2016 ClinicalKey
    Rasmussen, Todd E.; Rich, Norman M.; Tai, Nigel R. M.
    Published in association with the Society for Vascular Surgery (SVS), the newly updated edition of Rich's Vascular Trauma draws on civilian and military authorities from around the world to offer comprehensive and up-to-date coverage of the management of vascular injury. Anatomic patterns of vascular trauma including extremity, torso and cervical injury are reviewed in detail, including the latest techniques to manage non-compressible torso hemorrhage. You'll have access to all of the current innovations across the broad spectrum of vascular trauma, presented in a well-organized fashion that allows you to quickly hone-in on the most important issues in patient care and management.
  • 2012 Springer
    Mantis, Nicholas J.
    Interaction of Ricin and Shiga Toxins with Ribosomes -- How Ricin and Shiga Toxin Reach the Cytosol of Target Cells: Retrotranslocation from the Endoplasmic Reticulum -- Ricin and Shiga Toxins: Effects on Host Cell Signal Transduction -- Pathogenesis of Shiga-Toxin Producing Escherichia coli -- Shiga Toxin Pathogenesis: Kidney Complications and Renal Failure -- The Induction of Apoptosis by Shiga Toxins and Ricin -- Small-Molecule Inhibitors of Ricin and Shiga Toxins -- Immunity to Ricin: Fundamental Insights into Toxin-Antibody Interactions -- Animal Models of Ricin Toxicosis -- Ricin Vaccine Development.

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A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more.

Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.

MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available.Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.

Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences.

Includes cited reference searching, citation maps, and an analyze tool.

Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not.

Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.

Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.

Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities.

In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.

A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.

A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines.

Over 10,000 notes outline the status of specific infections within each country.

Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.

Provides online, full-text access to Springer's journal titles as well as journals from other publishers.

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Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.
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