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  • Systemic versus local renin angiotensin systems: An overview / W.C. DeMello and R.N. Re -- Clinical import of the local renin angiotensin aldosterone systems / E.D. Frohlich -- Renin, prorenin, and the (pro)renin receptor / G. Nguyen and A. Contrepas -- Local renin angiotensin systems in the cardiovascular system / R.N. Re -- Renin-angiotensin-aldosterone system and pathobiology of hypertension / P. Paradis and E.L. Schiffrin -- AT{subscript]1 receptors, angiotensin receptor blockade, and clinical hypertensive disease / R.M. Carey -- Structural and electrophysiological remodeling of the failing heart / W.C. DeMello -- Inhibiting the renin angiotensin aldosterone system in patients with heart failure and myocardial infarction / M.A. Pfeffer -- Left ventricular hypertrophy and treatment with renin angiotensin system inhibition / E.D. Frohlich and J. Díez -- Angiotensin-(1-7), angiotensin-converting enzyme 2, and new components of the renin angiotensin system / A.J. Trask ... [et al.] -- Kinin receptors and ACE inhibitors: An interrelationship / E.G. Erdös, F. Tan and R.A. Skidgel -- Kinins and cardiovascular disease / O.A. Carretero, X.-P. Yang and N.-E. Rhaleb -- CMS and type 2 diabetes mellitus: Bound together by the renin angiotensin aldosterone system / D. Gupta ... [et al.] -- Renin angiotensin aldosterone system and cardiovascular disease / S. Bernard ... [et al.] -- Renin angiotensin system and atherosclerosis / C. Hu and J.L. Mehta -- Renin angiotensin system and aging / L.F. Ferder.
  • Overview of the pancreas -- Physiology of the pancreas -- Common pancreatic disease -- Circulating RAS -- Local RAS -- Pancreatic RAS -- Basic techniques for pancreatic research -- Current research of the RAS in diabetes mellitus -- Current research concerning the RAS in pancreatic stem cells -- Current research of the RAS in pancreatitis and pancreatic cancer.
  • Thoroughly revised and updated, the New Edition of this definitive text explains how to care for neonates using the very latest methods of diagnosis and treatment. This 5th edition represents the state-of-the-art on neonatal care, providing not only detailed pathophysiology and clinical chapters on every condition of the neonate but also comprehensive chapters on the psychosocial aspects of neonatology, such as handling perinatal death and ethical and legal aspects of neonatal care. Contributions from Fetal Medicine experts and Obstetricians provide valuable peripheral information essential to the practice of neonatology. This book is the gold standard for neonatal care and will be an invaluable tool for everyone involved in the care of the neonate. It serves as an authoritative reference for practitioners, a valuable preparation tool for neonatal certification exams, and a useful resource for the entire neonatal care team.
  • Provides tools to assist emergency planners in evaluating the feasibility of, and requirements for, reopening shuttered hospitals in their local communities to expand surge capacity during a mass casualty event
  • Reoperative Hand Surgery is a major contribution to the literature, offering a wide range of reoperative options for challenging problems that face the reconstructive hand surgeon after failed primary surgery. Concise and discussing all of the more common issues that hand surgeons often face in performing revision surgery, this invaluable title is unique in that it looks specifically at the problem of what to do when the original index procedure did not go as planned. Topics covered include the hand, wrist, forearm and elbow, and several sections of the book discuss some of the psychological and social factors that also go into the decision process to reoperate or not. The chapters are tightly focused so that the important aspects to consider for reoperation can be quickly reviewed. There is also a component that discusses how to avoid other pitfalls and to minimize as well as manage any complications that may occur with reoperative procedures. Importantly, the book is replete with original art work to help describe and demonstrate how to perform many reoperative procedures. The artwork is simple and straightforward but yet detailed enough to convey the important steps and aspects for the surgical intervention it is outlining. Developed by renowned experts in the hand surgery field, Reoperative Hand Surgery is an indispensable, state-of-the-art reference, offering the busy hand and upper extremity surgeon easily accessible information relating to the evaluation, diagnosis, and possible surgical interventions for the diagnoses discussed.
  • Attachment and cell entry of mammalian orthoreovirus / K.M. Guglielmi ... [et al.] -- Early steps in rotavirus cell entry / S. Lopez and C.F. Arias -- Early steps in avian reovirus morphogenesis / J. Benavente and J. Martinez-Costas -- Bluetongue virus assembly and morphogenesis / P. Roy and R. Noad -- Reovirus structure and morphogenesis / K.M. Coombs -- Rotavirus genome replication and morphogenesis : role of the viroplasm / J.T. Patton ... [et al.] -- Rotavirus proteins : structure and assembly / J.B. Pesavento ... [et al.] --- Structural studies on orbivirus proteins and particles / D.I. Stuart and J.M. Grimes -- Rotavirus assembly : an alternative model that utilizes and atypical trafficking pathway / S. Chwetzoff and G. Trugnan.
  • Tendon repair and regeneration: an overview / Eric M. Bluman, Scott D. Allen, Paul D. Fadale -- Structure and function of ligaments, tendons, and joint capsule / Frederick H. Silver, Joseph W. Freeman, Gino Bradica -- Tendons of the hand: anatomy, repair, healing, and rehabilitation / Paul C. Stephens ... [et al.] -- Evolution of concepts in flexor tendon surgery of the hand / Randip R. Bindra -- Basic science of the shoulder ligaments / Louis J. Soslowsky and Jeffrey S. Cartmell -- History of cruciate ligaments: development of repair and reconstruction / Jon Karlsson -- Rotator cuff / Richard O. Evans, Peter J. Hughes, David H. Sonnabend -- Frozen shoulder / Peter J. Hughes, Richard O. Evans, Jerome A. Goldberg -- Capsular shrinkage of the shoulder: current clinical status / Andrew L. Wallace -- Biomechanical and clinical evaluation of tendons and ligaments / David Hartright ... [et al.] -- Healing of ligament and tendon to bone / Andreas Weiler, Sven Scheffler, Maria Apreleva -- Artificial ligaments / Andrew A. Amis -- Tendon and ligament fixation to bone / Christopher M. Hill, Yuehuei H. An, Frank A. Young -- Tissue engineering strategies for regeneration of the anterior cruciate ligament / Michael G. Dunn -- Gene therapy and ligament healing / Norimasa Nakamura.
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  • Repetitive DNA 2012
    The Repetitive DNA Content of Eukaryotic Genomes / López-Flores, I.; Garrido-Ramos, M.A. -- Telomere Dynamics in Mammals / Silvestre, D.C.; Londoño-Vallejo, A. -- Drosophila Telomeres: an Example of Co-Evolution with Transposable Elements / Silva-Sousa, R.; López-Panadès, E.; Casacuberta, E. -- The Evolutionary Dynamics of Transposable Elements in Eukaryote Genomes / Tollis, M.; Boissinot, S. -- SINEs as Driving Forces in Genome Evolution / Schmitz, J. -- Unstable Microsatellite Repeats Facilitate Rapid Evolution of Coding and Regulatory Sequences / Jansen, A.; Gemayel, R.; Verstrepen, K.J. -- Satellite DNA Evolution / Plohl, M.; Meštrović, N.; Mravinac, B. -- Satellite DNA-Mediated Effects on Genome Regulation / Pezer, Ž.; Brajković, J.; Feliciello, I.; Ugarković, Đ. -- The Birth-and-Death Evolution of Multigene Families Revisited / Eirín-López, J.M.; Rebordinos, L.; Rooney, A.P.; Rozas, J. -- Chromosomal Distribution and Evolution of Repetitive DNAs in Fish / Cioffi, M.B.; Bertollo, L.A.C..
  • Repetitive transcranial magnetic stimulation (rTMS) treatment is increasingly being used in the management of patients with depression. Since the approval of one rTMS device in the United States in 2008, clinical services using this equipment have become relatively common there, and services are also being developed in a variety of other countries. However, considerable ignorance exists about the treatment in general psychiatric practice. This concise clinical guide will serve as a reference and practical tool for clinicians working with or learning about this treatment technique. The opening chapters provide basic information on the history and development of rTMS treatment and its mechanism of action. Use of the treatment in depression is then addressed in detail, with explanation of the evidence base and discussion of clinical issues such as selection of patients and type of treatment, dose, and treatment duration. Side-effects of treatment are explored, and careful consideration is given to various practical issues concerning the establishment of rTMS treatment programs and the training of clinicians. The final chapters will provides a brief overview of potential rTMS applications in other psychiatric conditions and some background on the use of related treatments, such as transcranial direct current stimulation.
  • Live vaccines and their role in modern vaccinology / Gordon Dougan, David Goulding, and Lindsay J. Hall -- Live attenuated vaccines : influenza, rotavirus and varicella zoster virus / Harry B. Greenberg and Ann M. Arvin -- Classical live viral vaccines / Thomas P. Monath -- Recombinant live vaccines to protect against the severe acute respiratory syndrome coronavirus / Luis Enjuanes ... [et al.] -- Live-attenuated Shigella vaccines. Is encouraging good enough? / Yves Germani and Philippe J. Sansonetti -- New generation BCG vaccines / Michael V. Tullius and Marcus A. Horwitz -- Basic science paves the way to novel safe and effective pestivirus vaccines / Norbert Tautz and Gregor Meyers -- Live attenuated influenza virus vaccines : NS1 truncation as an approach to virus attenuation / Natalie Pica, Peter Palese, and John Steel -- An attenuated HSV-1 live virus vaccine candidate that is replication competent bu defective in epithelial cell-to-cell and neuronal spread / Elizabeth E. Zumbrun and Harvey M. Frieman -- Live attenuated vaccines for respiratory syncytial virus / Michael N. Teng -- Live attenuated cholera vaccines : flagella and reactogenicity / D. Ewen Cameron and John J. Mekalanos -- Replication-defective herpes simplex virus mutant strains as genital herpes vaccines and vaccine vectors / David M. Knipe -- Nucleic acid-based infections and pseudo-infectious flavivirus vaccines / Justin A. Roby, Roy A. Hall, and Alexander A. Khromykh -- Application of cleavage activation mutants of influenza virus as live vaccines / Juergen Stech and Hans-Dieter Klenk -- Alphavirus particle-based vaccine vectors / Scott J. Balsitis, Clayton W. Beard, and Peter W. Mason -- Recombinant chimeric, live attenuated vaccines against flaviviruses and alphaviruses / Thomas P. Monath.
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  • Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
  • Volume 2 has country-by-country analysis.
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    v. 1. Results of the initial evaluation phase.
  • The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.
  • The report includes listings of substances, divided into two categories: known human carcinogens and substances reasonably anticipated to be human carcinogens.
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  • Reporter genes a practical guide 2007
    Springer Protocols
    Methodologies for staining and visualization of [beta]-galactosidase in mouse embryos and tissues / Siobhan Loughna and Deborah Henderson -- Immunohistochemical detection of [beta]-galactosidase or green fluorescent protein on tissue sections / Philip A. Seymour and Maike Sander -- Detection of reporter gene expression in murine airways / Maria Limberis, Peter Bell, and James M. Wilson -- Three-dimensional analysis of molecular signals with episcopic imaging techniques / Wolfgang J. Weninger and Timothy J. Mohun -- Fluorescent proteins for cell biology / George H. Patterson -- Detection of GFP during nervous system development in Drosophila melanogaster / Karin Edoff, James S. Dods, and Andrea H. Brand -- Autofluorescent proteins for flow cytometry / Charles G. Bailey and John E. J. Rasko -- Fluorescent protein reporter systems for single-cell measurements / Steven K. Dower, Eva E. Qwarnstrom, and Endre Kiss-Toth -- Subcellular imaging of cancer cells in live mice / Robert M. Hoffman -- Noninvasive imaging of molecular events with bioluminescent reporter genes in living subjects / Pritha Ray and Sanjiv Sam Gambhir -- Green fluorescent protein as a tracer in chimeric tissues : the power of vapor fixation / Harald Jockusch and Daniel Eberhard.
  • Perspectives on reproduction and life history in baboons / Larissa Swedell & Steven R. Leigh -- Infant mortality, paternity certainty, and female reproductive strategies in hamadryas baboons / Larissa Swedell & Julian Saunders -- Female behavioral strategies of hybrid baboons in the Awash National Park, Ethiopia / Jacinta C. Beehner & Thore J. Bergman -- Hybrid baboons and the origins of the hamadryas male reproductive strategy / Thore J. Bergman -- The social and ecological flexibility of Guinea baboons : implications for Guinea baboon social organization and male strategies / Anh Galat-Luong, Gérard Galat & Suzanne Hagell -- Social organization, reproductive systems, and mediation of baboon endogenous virus (BaEV) copy number in gelada, hamadryas, and other Papio baboons / Monica Uddin, Jane E. Phillips-Conroy & Clifford J. Jolly -- Reproduction, mortality, and female reproductive success in chacma baboons of the Okavango Delta, Botswana / Dorothy L. Cheney ... [et al.] -- Maternal characteristics and offspring growth in chacma baboons : a life-history perspective / Sara E. Johnson -- Whose life is it anyway? Maternal investment, developmental trajectories, and life history strategies in baboons / Louise Barrett, S. Peter Henzi & John E. Lycett -- Ontogeny, life history, and maternal investment in baboons / Steven R. Leigh & Robin M. Bernstein -- Testicular size, developmental trajectories, and male life history strategies in four baboon taxa / Clifford J. Jolly & Jane E. Phillips-Conroy -- The evolutionary past and the research future : environmental variation and life history flexibility in a primate lineage / Susan C. Alberts & Jeanne Altmann.
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    v. 1. Germ cells and fertilization.--v. 2. Embryonic and fetal development.--v. 3. Hormones in reproduction.--v. 4. Reproductive patterns.--v. 5. Artificial control of reproduction.--Book 6. The evolution of reproduction. --Book 8. Human sexuality.
  • Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.
  • Basis for molecular reproductive biology -- Introduction to the molecular organization of the endocrine/reproductive system -- Extracellular signaling receptors -- Molecules that transmit information into the cell: the intracellular signaling pathways -- Introduction to molecular biology: structure and function of the macromolecules of genetic information -- Regulation of gene expression -- Molecular basis of abnormal phenotype -- Tools of molecular reproductive biology -- Recombinant DNA technology -- Techniques for DNA analysis -- Analyzing gene expression -- DNA microarray analysis -- Computer assisted analysis of genes -- Introduction to gene therapy -- Molecular regulation of reproductive hormones -- GnRH-GnRH-receptor system in the mammalian female reproductive tract -- FSH: one hormone with multiple forms, or a family of multiple hormones -- FSH receptor: one receptor with multiple forms or a family of receptors -- Regulation of the early steps in gonadal steroidogenesis -- Prostaglandins and their mechanisms of action in the cyclic ovary -- Androgens: molecular basis and related disorders -- Leptin as a reproductive hormone -- Neurosteroids and sexual behavior and reproduction -- Molecular regulation of the reproductive organs and tissues -- Autocrine and paracrine regulation of the ovary -- Ovarian endocrine activity: role of follistatin, activin, and inhibin -- Hormonal and molecular regualtion of the cytochrome P450 aromatase gene expression in the ovary -- Epigenetic mechanisms of ovarian gene regulation -- Ovarian function and failure: the role of the oocyte and its molecules -- Molecular control of corpus luteum function -- Molecular landscape of spermatogonial stem cell renewal, meiotic sex chromosome inactivation, and spermatic head shaping.
  • Characteristics of a successful R.E.I. clinic and laboratory -- Assisted reproductive technology practice management -- Collaboration within the reproductive endocrinology and infertility practice: integration of laboratory and clinic operations -- Informed consent in advanced reproductive technology -- Reproductive laboratory regulations, certifications and reporting systems -- Successfully integrating the FDA regulations into your practice -- Psychosocial consequences of infertility and treatment -- A live baby or your money back: the marketing of in vitro fertilization procedures -- Ovulation: a molecular view -- Clinical evaluation of female factor infertility -- Polycystic ovary syndrome -- The current status for Metformin use in reproductive medicine -- Clinical aspects of endometriosis -- Common endocrinopathies in reproductive endocrinology -- Acquired uterine factors and infertility -- Mullerian (paramesonephric) anomalies and associated Wolffian (mesonephric) duct malformations -- Recurrent miscarriage -- Laparoscopy in the diagnosis and treatment of female infertility -- Turner syndrome -- Errors in chromosome segregation during oogenesis and early embryogenesis -- An overview of sperm production -- Meiotic recombination and errors during spermatogenesis -- Clinical evaluation and treatment of male factor infertility -- Semen analysis: essentials for the clinician -- Sperm capacitation, the acrosome reaction, and fertilization -- Advanced tests of sperm function -- Genetic testing of male infertility Varicocele and male infertility -- Sperm retrieval techniques -- The clinical utility of the evaluation of sperm chromatin -- Artificial insemination: intrauterine insemination -- Sperm preparation for artificial insemination -- Sperm banking, donation, and transport in the age of assisted reproduction: federal and state regulation -- Reproductive treatment of HIV-1 discordant couples -- Ovulation induction -- Transvaginal sonography in reproductive endocrinology and infertility -- Establishing the IVF laboratory: a systems view -- Preparation and selection of sperm for IVF and ICSI -- The genetic and epigenetic contributions of sperm to early embryogenesis -- Micromanipulation of human oocytes and embryos: applications of intracytoplasmic sperm injection and assisted hatching in infertility treatment -- Embryo culture techniques -- In-vitro maturation of human oocytes -- Integrating preimplantation genetic diagnosis into the ART laboratory -- Evaluation and selection of preimplantation embryos for transfer -- Embryo transfer in IVF: evidence-based clinical practice -- Cryopreservation of human oocytes and embryos -- Preserving fertility -- Ovarian hyperstimulation syndrome -- Pregnancy outcomes in infertile couples -- The impact of complementary medicine on in-vitro fertilization -- Designing a clinical research infrastructure -- Integrating research into a clinical practice -- Research regulations: the role of the Institutional Review Board -- Technology transfer and its role in the practice of reproductive endocrinology and infertility -- The environment and reproduction: endocrine disruption, reproductive impairment, and epigenetics.
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    Foundations of reproductive epidemiology -- Environments in reproductive epidemiology -- Research process in reproductive epidemiology -- Surveillance in reproductive epidemiology -- Descriptive reproductive health indicators -- Study designs in reproductive epidemiology -- Causal inference in reproductive epidemiology -- Nutrition and reproductive health -- Contraception and reproductive health -- Mercury, lead, environmental estrogens, and reproductive health -- Psychosocial factors and reproductive health -- Early childbearing : trends and consequences -- Cancer risk associated with early and late maternal age at first birth.
  • Principles of cancer treatment: impact on reproduction -- Fertility preservation options for females -- Options for fertility preservation in men and boys with cancer -- Contraception and cancer treatment in young persons -- Sexual health during cancer treatment -- Unique reproductive concerns of young women with breast cancer -- Pregnancy and cancer -- Preimplantation genetic diagnosis for hereditary cancers -- Non-traditional family building planning -- Parenting with cancer I: developmental perspective, communication, and coping -- Parenting with cancer II: parenting at different stages of illness -- Pediatric oncology and reproductive health -- Institutional approaches to implementing fertility preservation for cancer patients -- Patient provider communication and reproductive health -- Fertility preservation in cancer patients: ethical considerations -- Legal issue and of assisted reproductive technologies.
  • Introduction -- Environmental Impact on Reproductive Health, Recent Trends and Developments / P. Nicolopoulou-Stamati and N.J. Lelos. Section 1: The Link Between Reproductive Health and Environment. -- Epidemiological Studies on the Relationship between Semen Quality and Environmental Chemicals: Historic and Contemporary Compounds / R. Hauser and J.D. Meeker -- Environment and Fertility / P. Saldiva. Section 2: Reproductive Health Effects. -- Male Reproductive Status and its Relationship with Man-Made, Hormone-Disrupting Substances: Studies In Flanders, Belgium / W. Dhooge, F. Eertmans, A. Mahmoud, and F. Comhaire -- Potential Impact of the Environment on the Male Reproductive Function: The Example Of Cryptorchidism / E. Huyghe, R. Mieusset and P.F. Thonneau -- Advanced Glycation End Products in Polycystic Ovarian Syndrome / E. Diamanti-Kandarakis, C. Piperi, and P. Nicolopoulou-Stamati -- Oocytes and Ovarian Follicles as Targets of Endocrine Disrupters: Consequences for Reproductive Health / F. Gandolfi, T.A.L. Brevini, and F. Cillo. Section 3: Pollutants And Exposure. -- Non-Pesticide Endocrine Disrupters and Reproductive Health / S. Corsolini -- Medical Drugs Impairing Fertility / N. Pandiyan -- Impact of Air Pollution on Reproductive Health in Northern Bohemia / J. Rubes, S.G. Selevan, R.J. Sram, D.P. Evenson, and S.D. Perreault. Section 4: Policy Instruments And Issues. -- Pesticides as Endocrine Disrupters: Identification of Hazards for Female Reproductive Function / M. Rescia and A. Mantovani -- Assessment of Fertility and Other Health Impacts for Selected Pollutants in Flanders: Opportunities and Limitations / J. De Wit, A. Verspecht and L. Hens -- Problems in Assessing Low Dose Effects of Endocrine Disrupters / A. Gies -- Getting the Message Across - WWFs and ISDEs Perspectives on Communication Strategies to Reduce Exposures to Hazardous Chemicals / G. Lyons and P. Illig -- Environmental Ethics and Fertility in Early Cultures and The Industrial Age / A. Katsivelaki and C.E. Sekeris. Section 5: Regional Aspects. -- Reproductive Health Problems in the Greater Athens Area / D.A. Adamopoulos and E. Koukkou -- Environment and Reproductive Health in Bulgaria / S. Stoyanov and E. Terlemesian.
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    About these guidelines -- Introduction -- Indicators-an overview in the context of global monitoring -- Generation, interpretation and analysis of the shortlisted national reproductive health indicators -- 1. Total fertility rate -- 2. Contraceptive prevalence -- 3. Maternal mortality ratio -- 4. Antenatal care coverage -- 5. Births attended by skilled health personnel -- 6. Availability of basic essential obstetric care -- 7. Availability of comprehensive essential obstetric care -- 8. Perinatal mortality rate -- 9. Prevalence of low birth weight -- 10. Prevalence of positive syphilis serology in pregnant women -- 11. Prevalence of anaemia in women -- 12. Percentage of obstetric and gynaecological admissions owing to abortion -- 13. Reported prevalence of women with genital mutilation -- 14. Prevalence of infertility in women -- 15. Reported incidence of urethritis in men -- 16. Prevalence of HIV infection in pregnant women -- 17. Knowledge of HIV-related preventive practices -- Annex 1. Millennium Development Goals and associated targets -- Annex 2. The selection criteria for the shortlist of indicators.
  • Part 1. Introduction. Reproductive science as an essential component of conservation biology / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- "Mayday mayday mayday", the Millennium Ark is sinking? / Steven L. Monfort -- Part 2. The big picture: can species survive and adapt in a changing world? Climate change, extinction risks, and reproduction of terrestrial vertebrates / Cynthia Carey -- Impacts of endocrine disrupting chemicals on reproduction in wildlife / Emmelianna Kumar and William V. Holt -- The role of genomics in conservation and reproductive sciences / Warren E. Johnson and Klaus Koepfli -- The epigenetic basis of adaptation and responses to environmental change: perspective on human reproduction / Agustín F. Fernández, Estela García Toraño, Rocío González Urdinguio, Abel Gayo Lana, Ignacio Arnott Fernández, and Mario F. Fraga -- The black-footed ferret: on the brink of recovery? / Rachel M. Santymire, Travis M. Livieri, Heather Branvold-Faber, and Paul E. Marinari -- Comparative reproductive biology of elephants / Janine L. Brown -- The koala (Phascolarctos cinereus): a case study in the development of reproductive technology in a marsupial / Stephen D. Johnston and William V. Holt -- Reproduction and advances in reproductive studies in carnivores / Katarina Jewgenow and Nucharin Songsasen -- Methods to examine reproductive biology in free-ranging, fully-marine mammals / Janet M. Lanyon and Elizabeth A. Burgess -- Amphibian declines in the twenty-first century: why we need assisted reproductive technologies / John Clulow, Vance L. Trudeau, and Andrew J. Kouba -- The reality, use and potential for cryopreservation of coral reefs / Mary Hagedorn and Rebecca Spindler -- Recent advances and prospects in germplasm preservation of rare and endangered species / Pierre Comizzoli and William V. Holt -- Sperm DNA fragmentation and its role in wildlife conservation / Jaime Gosálvez, William V. Holt, and Stephen D. Johnston -- Somatic cells, stem cells, and induced pluripotent stem cells: how do they now contribute to conservation? / Gabriela F. Mastromonaco, L. Antonio González-Grajales, Melissa Filice, and Pierre Comizzoli -- Biosafety in embryos and semen cryopreservation, storage, management and transport / A. Bielanski -- Fertility control in wildlife: review of current status, including novel and future technologies / Deborah Garside, Ayman Gebril, Manal Alsaadi, and Valerie A. Ferro -- Cloning the mammoth: a complicated task or just a dream? / Pasqualino Loi, Joseph Saragusty, and Grazyna Ptak -- Conclusions: environmental change, wildlife conservation and reproduction / William V. Holt, Janine L. Brown, and Pierre Comizzoli -- Index.
  • This evidence-based book examines the role of reproductive surgery in the current age of IVF and in modern medical practice. The authors provide a detailed insight into surgical techniques and where such practices stand relative to other fertility treatments such as assisted conception techniques. Reproductive Surgery in Assisted Conception is a useful reference book for current practicing reproductive surgeons as well as those training in the field. It is also invaluable to other fertility practitioners wishing to gain more insight into how and when surgical intervention may be used as either a standalone fertility treatment or to improve success rates of other fertility treatments.
  • "Metabolic engineering has been developed over the past 20 years to become an important tool for the rational engineering of industrial microorganisms. This book has a particular interest in the methods and applications of metabolic engineering to improve the production and yield of a variety of different metabolites. The overall goal is to achieve a better understanding of the metabolism in different microorganisms, and provide a rational basis to reprogram microorganisms for improved biochemical production. This book brings together contributions from leading researchers at the cutting edge of these topics. The subject matter is divided into two sections. The first section deals with novel and emerging methods for redesigning microorganisms exploiting systems biology and gene regulation. The second discusses practical aspects of metabolic engineering for over production of a variety of valuable chemicals and materials by fermentation."--Publisher's description.
  • "This overview outlines the statutory background for WHO's research, identifies the milestones in health research over five decades, and discusses issues of both process and programs. This report also includes accounts of regional efforts in health research"--Publisher's description. African region; Eastern Mediterranean region; European region; South East Asia region; Western Pacific region; Pan American Health Organization
  • It has become increasingly accepted that important digital data must be retained and shared in order to preserve and promote knowledge, advance research in and across all disciplines of scholarly endeavor, and maximize the return on investment of public funds. To meet this challenge, colleges and universities are adding data services to existing infrastructures by drawing on the expertise of information professionals who are already involved in the acquisition, management and preservation of data in their daily jobs. Data services include planning and implementing good data management practices, thereby increasing researchers' ability to compete for grant funding and ensuring that data collections with continuing value are preserved for reuse. This volume provides a framework to guide information professionals in academic libraries, presses, and data centers through the process of managing research data from the planning stages through the life of a grant project and beyond. It illustrates principles of good practice with use-case examples and illuminates promising data service models through case studies of innovative, successful projects and collaborations.
  • Research in Clinical Practice is a neat, pocket-sized reference guide examining how to get the most from actively participating in research. Including how to begin, avoiding pitfalls, whom to approach and what questions to ask - all significant practicalities for conducting research in the reader's area of interest. Each reader will learn how to make the best use of such a valuable time. Written by two experienced surgeons, both of whom achieved post graduate research degrees, Research in Clinical Practice, is an essential tool for clinicians embarking on a research project as well as those who are new to supervising researchers.
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  • Topics include self-Management, self-Efficacy, health Status, and some diabetes-specific scales.
  • This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers research methods in biomineralization science, and includes sections on such topics as determining solution chemistry, structure and nucleation; probing structure and dynamics at surfaces; and interfaces mapping biomineral and morphology and ultrastructure.
  • The orthodontic literature includes many articles on basic science and engineering research techniques, but clinicians are typically unfamiliar with the principles underlying these techniques and may also lack the background knowledge required for a full appreciation of their role. This book comprehensively reviews a wide array of the research methods most frequently encountered in the literature, encompassing the areas of materials science and clinical and biological research. The various methods and techniques are carefully described, and their indications and limitations are explained. All of the information is up to date, reflecting latest developments.For practicing professionals, Research Methods in Orthodontics will be an ideal introduction to instrumental analysis and basic science research methods in the field. It will also serve as an excellent reference guide for researchers. By familiarizing orthodontists with the basics of research methods, the book will boost their ability to keep pace with developments in treatment approaches, materials, and techniques and assist in the transfer of relevant future findings into practice.
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    Ethical and practice issues in qualitative research / Frances Sheldon and Anita Sargeant -- Evaluating qualitative research / Michelle Crossley -- Mixed methods for evaluation research / Christine Ingleton and Sue Davies -- Ethnography / Jane Seymour -- Documentary analysis and policy / Margaret O'Connor -- How to develop a research question / Laura Kelly and Patrick Stone -- Writing a research proposal / Chris Todd -- How to gain research ethics approval / Peter Speck -- How to use a statistician / Malcolm Campbell -- How to write a paper / Julia M. Addington-Hall. Principles of designing clinical trials in palliative care / Michael I. Bennett -- Ethical and practical issues in designing and conducting clinical trials in palliative care / Yolanda Zuriarrain Reyna, Michael I. Bennett, and Eduardo Bruera -- Survey design / Julia M. Addington-Hall -- Survey research : methods of data collection, questionnaire design, and piloting / Julia M. Addington-Hall -- Experimental and quasi-experimental designs / Massimo Costantini and Irene J. Higginson -- Outcome measurement / Irene J. Higginson and Richard Harding -- Systematic reviews / Marjolein Gysels and Irene J. Higginson -- Qualitative methods of data collection and analysis / Sheila Payne --
  • pt. B ScienceDirect
  • Trefoil factor family peptide 3 at the ocular surface / Schulze, U.; Sel, S.; Paulsen, F.P. -- Cationic amino acid transporters and [beta]-defensins in dry eye syndrome / Jäger, K. ... [et al.] -- Antimicrobial peptides as a major part of the innate immune defense at the ocular surface / Garreis, F.; Gottschalt, M.; Paulsen, F.P. -- Regulation of the inflammatory component in chronic dry eye disease by the eye-associated lymphoid tissue (EALT) / Knop, N.; Knop, E. -- Intravital multidimensional real-time imaging of the conjunctival immune system / Gehlsen, U.; Hüttmann, G.; Steven, P. -- Generation of two- and three-dimensional lacrimal gland constructs / Schrader, S. ... [et al.] -- Midterm results of cultivated autologous and allogeneic limbal epithelial transplantation in limbal stem cell deficiency / Pauklin, M. ... [et al.] -- Laser scanning confocal microscopy for conjunctival epithelium imaging / Jürgens, C. ... [et al.] -- Pollen enzymes degrade human tear fluid and conjunctival cells : an approach to understanding seasonal non-allergic conjunctivitis / Rabensteiner, D.F. ... [et al.] -- Towards a new in vitro model of dry eye : the ex vivo eye irritation test / Spöler, F.; Frentz, M.; Schrage, N.F. -- The lid margin is an underestimated structure for preservation of ocular surface health and development of dry eye disease / Knop, E. ... [et al.] -- Diagnostic markers of sjögrenʹs syndrome / Witte, T. -- Hyperosmolarity of the tear film in dry eye syndrome / Messmer, E.M.; Bulgen, M.; Kampik, A. -- Novel ocular lubricant containing an intelligent delivery system: details of its mechanism of action / Springs, C.
  • Part One: Beginning grantsmanship -- 1. The NIH and other sources of research support -- 2. A strong proposal -- 3. Proposal review -- 4. The R01 research grant -- 5. The abstract and specific aims -- 6. Background and significance -- 7. Preliminary studies -- 8. Research design and methods -- 9. The budget -- 10. Biographical sketch, research support, and resources -- 11. Human subjects -- 12. Animal subjects -- 13. Consortiums, contracts, consultants, and collaborators -- 14. Literature cited and appendixes -- 15. Revision of an unfunded proposal -- 16. Competing renewal of R01 projects (progress reports) -- 17. Proposal submission and supplementary materials -- 18. Your first grant award (R, F, or K) -- 19. Advice for beginners in academia. -- Part two: Advanced grantsmanship -- 20. Small business grants -- 21. Program project grants (P01) -- 22. Center grants -- 23. Construction grants -- 24. T32 institutional research training program grants -- 25. Instrumentation grants -- Appendix -- A. Information sources: private foundation and government web sites, and study section contacts -- B. Summary statements, reviewer comments, assignment, award, and triage letters -- C. Examples of figures from preliminary data -- D. Examples of design format -- E. Instructions to reviewers concerning human subjects -- F. Suggested reading.
  • "Comprehensive research and a highly trained workforce are essential for the improvement of health and health care both nationally and internationally. Over the past 40 years the National Research Services Award (NRSA) Program has played a large role in training the workforce responsible for dramatic advances in the understanding of various diseases and new insights that have led to more effective and targeted therapies. In spite of this program, the difficulty obtaining jobs after the postdoc period has discouraged many domestic students from pursuing graduate postdoc training. In the United States, more than 50 percent of the postdoc workforce is made up of individuals who obtained their Ph. D.s from other countries. Indeed, one can make a strong argument that the influx of highly trained and creative foreigners has contributed greatly to U.S. science over the past 70 years. Research Training in the Biomedical, Behavioral, and Clinical Research Sciences discusses a number of important issues, including: the job prospects for postdocs completing their training; questions about the continued supply of international postdocs in an increasingly competitive world; the need for equal, excellent training for all graduate students who receive NIH funding; and the need to increase the diversity of trainees. The book recommends improvements in minority recruiting, more rigorous and extensive training in the responsible conduct of research and ethics, increased emphasis on career development, more attention to outcomes, and the requirement for incorporating more quantitative thinking in the biomedical curriculum."--Publisher's description.
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    1. Violence against women as a health and development issue -- 2. Ethical considerations for researching violence against women -- 3. Developing a research strategy -- 4. Quantitative approaches to research -- 5. Qualitative approaches to research -- 6. The challenge of defining and measuring violence in quantitative research -- 7. Developing a sampling strategy -- 8. Tools for collecting quantitative data -- 9. Tools for collecting qualitative data -- 10. Building your research team -- 11. In the field -- 12. Analyzing quantitative data -- 13. Analyzing qualitative data -- 14. From research to action -- Appendix 1. The WHO Violence Against Women Instrument -- Appendix 2. Training exercises for interviewers -- Appendix 3. Suggested resources.
  • "Resident Readiness: General Surgery prepares you for success during your surgical internship. Inside is a full range of scenarios you may experience during your residency, supported by comprehension questions with detailed answer explanations and tips to help you remember. You will also learn the clinical problem-solving process so you can think quickly on your feet, especially when time is critical. With the book's step-by-step guidance, you will gain the confidence you need to perform at your best on Day One of your residency"-- Provided by publisher.
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  • Resilience: definitions, ambiguities, and applications -- Successful aging and resilience: applications for public health and health care -- Resilience and personality disorders in older age -- What do we know about resilience in older adults?: an exploration of some facts, factors, and facets -- Psychological resilience -- Physiological resilience -- Using the arts to promote resiliency among persons with dementia and their caregivers -- Promoting worker resilience over the lifecourse -- Resilience in aging: cultural and ethnic perspectives -- Civic engagement: policies and programs to support a resilient aging society -- Strengthened by the spirit: religion, spirituality, and resilience through adulthood and aging -- Resilience in chronic illness -- The relationship between resilience and motivation -- The association between resilience and survival among Chinese elderly -- Fostering resilience in dementia through narratives: contributions of multimedia technologies -- Building resilience in mild cognitive impairment and early-stage dementia: innovative approaches to intervention and outcome evaluation -- African-American caregivers finding resilience through faith -- The age-friendly New York City project: an environmental intervention to increase aging resilience -- Promoting resilience in small-scale, homelike residential care settings for older people with dementia: experiences from the Netherlands and the United States -- A geriatric mobile crisis response team: a resilience-promoting program to meet the mental health needs of community-residing older people -- Optimizing resilience in the 21st century -- Resilience in the workplace: job conditions that buffer negative attitudes toward older workers.
  • (Publisher-supplied data) Historically, the diagnosis of deafness in a child has been closely associated with profound disability, including such typical outcomes as unmet potential and a life of isolation. A major shift away from this negative view has led to improved prospects for deaf children. Resilience in Deaf Children emphasizes not only the capability of deaf individuals to withstand adversity, but also their positive adaptation through interactions with parents, peers, school, and community. In this engaging volume, leading researchers and professionals pay particular attention to such issues as attachment, self-concept, and social competence, which are crucial to the development of all young people. In addition, the volume offers strategies for family members, professionals, and others for promoting the well-being of deaf children and youth. Coverage includes: Attachment formation among deaf infants and their primary caregivers. Deaf parents as sources of positive development and resilience for deaf infants. Enhancing resilience to mental health disorders in deaf school children. Strength-based guidelines for improving the developmental environments of deaf children and youth. Community cultural wealth and deaf adolescents resilience. Self-efficacy in the management of anticipated work-family conflict as a resilience factor among young deaf adults. Resilience in Deaf Children is essential reading for researchers, clinicians, and graduate students in clinical child, school, and developmental psychology as well as for allied researchers and professionals in such disciplines as school counseling, occupational therapy, and social work.
  • Introduction and generation of chimeric and humanized mAbs -- mAbs targeted against cancer cells and antibodies targeted against the tumor microenvironment -- Antibodies directed against different major cancers: Effects when used alone or in combination with drugs -- Mechanisms of antibodies-mediated responses, in vitro and in vivo -- Molecular Pathways -- Molecular Signatures -- Identification of resistance targets for intervention -- Various chemicals that can sensitize resistant tumor cells -- Other mAbs -- Proteasome inhibitors -- Divalent mAbs -- Antibodies coupled to chemical inhibitors -- Antibodies coupled to cytokines -- Nanoparticles with mAbs.
  • "Resistance training is a form of strength training in which each effort is performed against a specific, opposing force generated by resistance. Increasing evidence-based research highlights the importance of not only aerobic exercise, but resistance training in the prevention, management, and treatment of many chronic conditions. This book presents research on the benefits of resistance training for chronic diseases/disorders. Chapters cover resistance training to treat cardiovascular disease, metabolic diseases, cancer, orthopedic diseases, and neuromuscular disorders"-- Provided by publisher.
  • A growing number of people suffer from so-called resistant hypertension, that is to say, high blood pressure that does not respond to treatment. This disorder is of great current interest and importance for public health, being a common clinical problem faced by both primary care clinicians and specialists. Furthermore, as older age and obesity are among the strongest risk factors for uncontrolled hypertension, the incidence of resistant hypertension will likely increase as the population becomes more elderly and heavier. While the prognosis of resistant hypertension is unknown, cardiovascular risk is undoubtedly increased since patients often have a history of long-standing, severe hypertension complicated by multiple other cardiovascular risk factors. This volume, compiled by a panel of world-renowned experts, offers a comprehensive exploration of resistant hypertension, covering epidemiology, complex diagnostic aspects, and the therapeutic options currently available, with due attention to overall treatment strategies. New therapeutic agents and procedures, such as renal denervation and baroreceptor stimulation, are also described. In addition, the book addresses the economic aspects of resistant hypertension and the role of the different professional figures, from GPs to hypertension specialists, in dealing with it.
  • An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Confusing ethical distinctions -- Ethics committees and case consultations -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Incentives for physicians to decrease services -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Testing for genetic conditions -- Ethical issues in public health emergencies.
  • Section I. Fundamentals of clinical ethics -- An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- Section II. Shared decision making -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Section III. Decisions about life-sustaining interventions -- Confusing ethical distinctions -- Ethics consultations and ethics committees -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Section IV. The doctor-patient relationship -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Section V. Conflicts of interest -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Measures to control health care costs -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Section VI. Ethical issues in clinical specialties -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Ethical issues in genomic medicine -- Ethical issues in public health emergencies -- Ethical issues in cross-cultural care.
  • "Every day clinicians encounter ethical dilemmas that have a direct impact on patient care. This timely Fourth Edition will give you expert guidance in approaching a wide range of ethical dilemmas and developing an action plan even when competing points of view have equal merit. Most chapters include real-life sample cases that the author walks through, discussing the salient issues and how to approach them." "This useful resource is a must-read for medical students and practicing professionals at every level of experience!"--BOOK JACKET.
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    Full text print version of RDA offers a snapshot that serves as an offline access point to RDA.
  • The book blends basic and clinical research on respiratory carcinogensis. The contributions tackle a variety of respiratory-related cancers, notably non-small cell lung carcinoma, pleural mesothelioma, mediastinal tumors, or larynx cancer. The focus is on the search for novel molecular markers, derived from easily accessible tissues in clinical settings, such as the serum or bronchoalveolar lavage fluid, which could help diagnose cancer at an early stage and have a prognostic therapeutic value. The transcriptional mechanisms which endow cells with the capacity for unlimited proliferation are considered, with silencing of tumor suppressor genes is the exemplar. Chapters provide insight into a variety of cancer-related disorders of the respiratory tract, novel ways of differential diagnosis and treatment. The aim is to bring the current clinical procedures into alignment with the latest basic research findings. The book is a text for respiratory researchers, clinicians, and pathologists.
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    Introduction to patient assessment / Robert L. Wilkins, Philip M. Gold -- Introduction to respiratory failure / Robert L. Wilkins, James R. Dexter -- Asthma / Robert L. Wilkins, Philip M. Gold -- Chronic obstructive pulmonary disease / Robert L. Wilkins, Philip M. Gold -- Cystic fibrosis / N. Lennard Specht -- Hemodynamic monitoring and shock / Robert L. Wilkins, James R. Dexter -- Pulmonary thromboembolic disease / James R. Dexter -- Heart failure / Arthur B. Marshak, George H. Hicks -- Smoke inhalation injury and burns / George H. Hicks, Carl A. Eckrode -- Near drowning / William F. Galvin -- Acute respiratory distress syndrome / Robert L. Wilkins, James R. Dexter -- Chest trauma / George H. Hicks, Carl A. Eckrode -- Postoperative atelectasis / Thomas P. Malinowski -- Interstitial lung disease / N. Lennard Specht -- Neuromuscular diseases / N. Lennard Specht, Rebekah Bartos Specht -- Bacterial pneumonia / Robert L. Wilkins, James R. Dexter -- Pneumonia in the immunocompromised patient / Philip M. Gold, N. Lennard Specht -- Sleep disordered breathing / Enrique Gil -- Tuberculosis / James R. Dexter, Robert L. Wilkins -- Lung cancer / Gregory A.B. Cheek -- Appendix A: Normal laboratory values -- Appendix B: GOLD standards for diagnosing and treating patients with COPD -- Appendix C: Websites useful for learning information about the diagnosis and treatment of lung diseases.
  • Respiratory health 2015
    The tracheobronchial tree is open to the environment surrounding the body. Respiration has thus the essential bearing on general morbidity, vulnerability to disease and immunity. Further, respiratory function shapes the neuropsychological responses to succumbing to disease, controls the mind-to-body interaction and sets the perception of quality of life. The chapters of this book deal with the preventable drivers of poor respiratory health, the role of health information technology, the improvement in health care delivery and the integration of respiratory health and behavioral health services. Innovative strategies to promote prevention, care coordination and care integration as well as to align disease acceptance and quality of life measures also are tackled. Maintaining respiratory health is of rising research interest as a way of preventing a disease or a non pharmacological therapeutic succor. The book will be of interest to clinicians, family practitioners and medical researchers.
  • Soluble urokinase plasminogen activator receptor: an indicator of pneumonia severity in children / Wrotek, T. Jackowska, and K. Pawlik -- Detection of respiratory tract pathogens with molecular biology methods / Wozniak-Kosek, J. Kosek, and B. Zielnik-Jurkiewicz -- Classical against molecular-genetic methods for susceptibility testing of antituberculotics / I. Porvaznik, J. Mokry, and I. Solovic -- Does customer information fulfill MEDDEV criteria in cases of product problems of in vitro diagnostics for infection testing? / Jürgen Hannig and Rüdiger Siekmeier -- Sodium and copeptin levels in children with community acquired pneumonia / August Wrotek, Teresa Jackowska, and Katarzyna Pawlik -- Etiological factors causing lower respiratory tract infections isolated from hospitalized patients / A. Guzek, Z. Rybicki, K. Korzeniewski, K. Mackiewicz, E. Saks, A. Chciałowski, and E. Zwolińska -- Antibiotic consumption pattern in the neonatal special care unit before and after implementation of the hospital's antibiotic policy / Nitsch-Osuch, D. Kurpas, E. Kuchar, K. Życińska, T. Zielonka, and K. Wardyn -- Respiratory tract infections in children in primary healthcare in Poland / E. Kuchar, K. Miśkiewicz, L. Szenborn, and D. Kurpas -- Impact of updated European consensus guidelines on the management of neonatal respiratory distress syndrome on clinical outcome of preterm infants / S. Smolarova, L. Kocvarova, K. Matasova, M. Zibolen, and A. Calkovska -- Index.
  • Respiratory Muscle Training: theory and practice is the world's first book to provide an "everything-you-need-to-know" guide to respiratory muscle training (RMT). Authored by an internationally-acclaimed expert, it is an evidence-based resource, built upon current scientific knowledge, as well as experience at the cutting-edge of respiratory training in a wide range of settings. The aim of the book is to give readers: 1) an introduction to respiratory physiology and exercise physiology, as well as training theory; 2) an understanding of how disease affects the respiratory muscles and the mechanics of breathing; 3) an insight into the disease-specific, evidence-based benefits of RMT; 4) advice on the application of RMT as a standalone treatment, and as part of a rehabilitation programme; and finally, 5) guidance on the application of functional training techniques to RMT. The book is divided into two parts - theory and practice. Part I provides readers with access to the theoretical building blocks that support practice. It explores the evidence base for RMT as well as the different methods of training respiratory muscles and their respective efficacy. Part II guides the reader through the practical implementation of the most widely validated form of RMT, namely inspiratory muscle resistance training. Finally, over 150 "Functional" RMT exercises are described, which incorporate a stability and/or postural challenge - and address specific movements that provoke dyspnoea. Respiratory Muscle Training: theory and practice is supported by a dedicated website (, which provides access to the latest information on RMT, as well as video clips of all exercises described in the book. Purchasers will also receive a three-month free trial of the Physiotec software platform (via, which allows clinicians to create bespoke training programmes (including video clips) that can be printed or emailed to patients. Introductory overviews of respiratory and exercise physiology, as well as training theory Comprehensive, up-to-date review of respiratory muscle function, breathing mechanics and RMT Analysis of the interaction between disease and respiratory mechanics, as well as their independent and combined influence upon exercise tolerance Analysis of the rationale and application of RMT to over 20 clinical conditions, e.g., COPD, heart failure, obesity, mechanical ventilation Evidence-based guidance on the implementation of inspiratory muscle resistance training Over 150 functional exercises that incorporate a breathing challenge - access up-to-date information, video clips of exercises and a three-month free trial of Physiotec's RMT exercise module (via
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    Structure and function: how the architecture of the lung subserves its function -- Ventilation: how gas gets to the alveoli -- Diffusion: how gas gets across the blood-gas barrier -- Blood flow and metabolism: how the pulmonary circulation removes gas from the lung and alters some metabolites -- Ventilation-perfusion relationships: how matching of gas and blood determines gas exchange -- Gas transport by the blood: how gases are moved to the peripheral tissues -- Mechanics of breathing: how the lung is supported and moved -- Control of ventilation: how gas exchange is regulated -- Respiratory system under stress: how gas exchange is accomplished during exercise, at low and high pressures, and at birth -- Tests of pulmonary function: how respiratory physiology is applied to measure lung function.
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  • Respiratory physiology -- Disorders of the pediatric chest -- Respiratory monitoring -- Bronchoscopy in the pediatric intensive care unit -- Acute lung injury and acute respiratory distress syndrome -- Mechanical ventilation -- Ventilator-induced lung injury -- Prone positioning -- High-frequency oscillatory ventilation -- Pulmonary surfactant: biology and therapy -- Nitric oxide -- Extracorporeal life support for children with acute respiratory failure -- Diseases of the upper respiratory tract -- Congenital airway and respiratory tract anomalies -- Status asthmaticus -- Bronchiolitis -- Pneumonia and empyema -- Pediatric lung transplantation -- Neuromuscular respiratory failure -- Diseases of the pulmonary vascular system.
  • This volume provides a modern look on the age-old influenza infection and the preventive role of anti-influenza shots. Influenza pandemic outbreaks are unrelenting despite the growing understanding of the molecular basis of viral infection and its spreads. A leap in medical technologies has revolutionized the design of new influenza vaccines. The chapters cover vaccination strategies in various age-groups of people and provide the extensive amount of knowledge on the immune response to influenza vaccination in a spectrum of disease conditions.
  • A health-care provider is likely to be the first professional contact for survivors of intimate partner violence or sexual assault. Evidence suggests that women who have been subjected to violence seek health care more often than non-abused women, even if they do not disclose the associated violence. They also identify health-care providers as the professionals they would most trust with disclosure of abuse. These guidelines are an unprecedented effort to equip healthcare providers with evidence-based guidance as to how to respond to intimate partner violence and sexual violence against women. They also provide advice for policy makers, encouraging better coordination and funding of services, and greater attention to responding to sexual violence and partner violence within training programmes for health care providers. The guidelines are based on systematic reviews of the evidence, and cover: 1. identification and clinical care for intimate partner violence 2. clinical care for sexual assault 3. training relating to intimate partner violence and sexual assault against women 4. policy and programmatic approaches to delivering services 5. mandatory reporting of intimate partner violence. The guidelines aim to raise awareness of violence against women among health-care providers and policy-makers, so that they better understand the need for an appropriate health-sector response. They provide standards that can form the basis for national guidelines, and for integrating these issues into health-care provider education.
  • This book disentangles the complex meanings of responsibility in nanotechnology development by focusing on its theoretical and empirical dimensions. The notion of responsibility is extremely diversified in the public discourse of nanoscale technologies. Addressed are major disciplinary perspectives working on nanotechnology, e.g. philosophy, sociology, and political science, as well as the major multidisciplinary areas relevant to the innovation process, e.g. technology assessment and ethics. Furthermore, the interplay between such expertises, disciplines, and research programmes in providing a multidisciplinary understanding of responsibility is emphasized.
  • Scientific research and ethics -- Ethical decision making -- Data acquisition and management -- Mentoring and collaboration -- Collaboration between academia and private industry -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The protection of human subjects in research -- Protecting vulnerable human subjects in research -- Genetics, cloning, and stem cell research -- International research.
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  • Restless legs syndrome 2009
    Introduction -- General introduction: Restless Legs Syndrome as a neurological conundrum -- Patient's perspective -- From 1685 to 2008: an introduction to Restless Legs Syndrome -- Restless Legs Syndrome as a movement disorder -- Restless Legs Syndrome and nocturnal myoclonus (periodic limb movements during sleep) -- Clinical science of Restless Legs Syndrome -- Basic science of Restless Legs Syndrome -- Epidemiology and genetics -- Epidemiology of Restless Legs Syndrome -- Genetics of Restless Legs Syndrome -- Pathophysiology -- Iron metabolic system -- Iron dysregulation in Restless Legs Syndrome -- Brain's dopaine systems and their relevance to Restless Legs Syndrome -- Neuroimaging in Restless Legs Syndrome -- Circadian rhythm of Restless Legs Syndrome -- Spinal cord, dopamine, opiates, and Restless Legs Syndrome -- Clinical science of Restless Legs Syndrome -- Diagnosis -- Diagnosis of Restless Legs Syndrome -- Differential diagnosis of Restless Legs Syndrome -- Periodic limb movements in sleep -- Sleep laboratory diagnosis of Restless Legs Syndrome -- Actigraph assessment of periodic leg movements and Restless Legs Syndrome -- Assessment of Restless Legs Syndrome features with standardized methods -- Comorbidities and special populations -- Restless Legs Syndrome and periodic limb movement disorder in childhood and adolescence -- Restless Legs Syndrome and pregnancy -- Restless Legs Syndrome and periodic limb movements in the elderly with and without dementia -- Restless Legs Syndrome in medical disorders -- Restless Legs Syndrome in neurological disorders -- Is the manifestation of the Restless Legs Syndrome related to a pain mechanism? -- Restless Legs Syndrome and psychiatric disorders -- Management -- Introduction to management of Restless Legs Syndrome -- Nonpharmacological considerations and treatment of Restless Legs Syndrome -- Dopaminergic therapy of Restless Legs Syndrome -- Opioid agents in the treatment of Restless Legs Syndrome -- Anticonvulsants in the treatment of Restless Legs Syndrome -- Iron treatment -- Additional agents and miscellaneous therapies -- Management of Restless Legs Syndrome in the hospital and during surgery -- Restless Legs Syndrome morbidity: sleep and quality of life -- History of the Restless Legs Syndrome Foundation.
  • Emergency Medical Services for Children / Derek S. Wheeler and Tom LeMaster -- Pediatric Cardiopulmonary Resuscitation / Vinay M. Nadkarni and Robert A. Berg -- Supplemental Oxygen and Bag-Valve-Mask Ventilation / Patricia Abboud, Jennifer Raake, and Derek S. Wheeler -- Assessment and Management of the Pediatric Airway / Derek S. Wheeler, James P. Spaeth, Renuka Mehta, Suriyanarayana P. Hariprakash, and Peter N. Cox -- Vascular Access / Jennifer Kaplan and Richard J. Brilli -- Shock: An Overview / Joseph A. Carcillo, Derek S. Wheeler, Neil W. Kooy, and Thomas P. Shanley -- Acute Respiratory Failure / Jennifer L. Turi and Ira M. Cheifetz -- Pediatric Transport Medicine / Derek S. Wheeler and W. Bradley Poss -- Withdrawal of Life Support / Kathleen L. Meert and Ashok P. Sarnaik -- Brain Death / Sam D. Shemie -- The Pathophysiology of Brain Death and Care of the Potential Organ Donor / Sam D. Shemie.
  • Resuscitation is a two-stage process comprising the achievement/maintenance of spontaneous circulation and post-resuscitation management. The approach is complex and multifaceted and entails the integration of new physiological insights, pharmacological options, and technological advances. The purpose of this volume, written by top experts in the field, is to promote, share, and disseminate new advances in resuscitation and post-resuscitation care. The issues addressed are wide ranging and of great topical interest or controversy. They include priorities of intervention, quality of resuscitation, use of mechanical supports, new defibrillation strategies, prevention of organ damage, strategies in cases of sudden cardiac death, new pharmacological treatments, and post-resuscitation care, including temperature management and prediction and improvement of outcome after cardiac arrest. Particular attention is devoted to up-to-date evidence from the most recent experimental and clinical trials on resuscitation science and to gold standard evidence-based resuscitation and post-resuscitation treatments and interventions. In addition, organizational models and integrated care systems for trauma are considered, and critical care education and the process of guideline development are reviewed.
  • Explanations, philosophy and theory in health inequalities research: towards a critical realist approach -- Values and social epidemiologic research -- Population-based data and community empowerment -- Differences that matter -- Context -- Place-based stress and chronic disease: a systems view of environmental determinants -- How goes the neighbourhood? Rethinking neighbourhoods and health research in social epidemiology -- Application of two schools of social theory to neighbourhood, place and health research -- Locating politics in social epidemiology -- Research tools in action -- Structural violence and structural vulnerability within the risk environment: theoretical and methodological perspectives for a social epidemiology of HIV risk among injection drug users and sex workers -- Realist review methods for complex health problems -- Addressing health equalities in social epidemiology: learning from evaluation(s) -- Making a difference -- Knowledge translation and social epidemiology: taking power, politics and values seriously -- Community-academic partnerships and social change -- Producing more relevant evidence: applying a social epidemiology research agenda to public health practice.
  • Retina 2008
    Diabetes -- Age-related macular degeneration -- Vascular obstructions -- Pediatric -- Trauma -- Tumors -- Retinal detachment and allied diseases -- Vitreous -- Macular diseases -- Retinal dystrophies -- White dot syndromes -- Inflammatory diseases -- Infectious diseases.
  • 1 Scleral buckling surgery -- 2 Vitrectomy surgery -- 3 23-gauge vitrectomy -- 4 25-gauge vitrectomy -- 5 Epiretinal membrane surgery -- 6 Macular hole surgery -- 7 Proliferative diabetic retinopathy and vitreous hemorrhage -- 8 Surgical management for open-globe injuries -- 9 Surgery for proliferative vitreoretinopathy -- 10 Surgery for submacular hemorrhage -- 11 Intravitreal injections -- 12 Pneumatic retinopexy -- 13 Fluid-air exchange/fluid-gas exchange -- 14 Drainage of choroidal hemorrhage, detachment, or effusion s-- 15 Vitreous implants -- 16 Vitreous biopsy for endophthalmitis or cytology -- 17 Treatment of advanced retinopathy of prematurity: peripheral retinal ablation -- 18 Scleral buckle surgery for retinal detachment associated with neonatal retinopathy of prematurity -- 19 Vitrectomy surgery for retinopathy of prematurity -- 20 Surgery for intraocular tumors -- 21 Vitrectomy technology and techniques.
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    v. 1. Basic science, inherited retinal disease, and tumors -- v. 2. Medical retina -- v. 3. Surgical retina.
  • Retina. 5th ed. v.1-3, 2013
    Unequalled in scope, depth, and clinical precision, Retina, 5th Edition keeps you at the forefront of today's new technologies, surgical approaches, and diagnostic and therapeutic options for retinal diseases and disorders. Comprehensively updated to reflect everything you need to know regarding retinal diagnosis, treatment, development, structure, function, and pathophysiology, this monumental ophthalmology reference work equips you with expert answers to virtually any question you may face in practice. Benefit from the extensive knowledge and experience of esteemed editor Dr. Stephen Ryan, five expert co-editors, and a truly global perspective from 358 other world authorities across Europe, Asia, Australasia the Americas.Examine and evaluate the newest diagnostic technologies and approaches that are changing the management of retinal disease, including future technologies which will soon become the standard.Put the very latest scientific and genetic discoveries, diagnostic imaging methods, drug therapies, treatment recommendations, and surgical techniques to work in your practice.
  • 1. Cellular and molecular mechanisms of retinal angiogenesis / M.A. Behzadian et. al -- 2. Animal models of choroidal neovascularization / M.L. Clark, J.A. Fowler, and J.S. Penn -- 3. Rodent models of oxygen-induced retinopathy / S.E. Yanni, G.W. McCollum, and J.S. Penn -- 4. Animal models of diabetic retinopathy / T.S. Kern -- 5. Neovascularization in models of branch retinal vein occlusion / R.P. Danis and D.P. Bingaman -- 6. Vasculogenesis and angiogenesis in formation of the human retinal vasculature / T. Chan-Ling -- 7. IGF-1 and retinopathy / L.E.H. Smith -- 8. Hypoxia and retinal neovascularization / B.A. Berkowitz -- 9. Hypoxia inducible Factor-1 and VEGF induction / A. Madan -- 10. The role of protein kinase C in diabetic retinal vascular abnormalities / J.K. Sun and G.L. King -- 11. Eph receptor tyrosine kinases: modulators of angiogenesis / J. Chen, D. Brantley-Siders, and J.S. Penn -- 12. Adenosine in retinal vasculogenesis and angiogenesis in oxygen-induced retinopathy / G.A. Lutty and D.S. McLeod -- 13. The regulation of retinal angiogenesis by cyclooxygenase and the prostanoids / G.W. McCollum and J.S. Penn -- 14. Extracellular proteinases in ocular angiogenesis / A. Das and P.G. McGuire -- 15. Oxygen-independent angiogenic stimuli / J.M. Holmes, D.A. Leske, and W.L. Lanier -- 16. Growth factor synergy in angiogenesis / A.V. Ljubimov -- 17. Pigment epithelium derived factor and angiogenesis / J. Amaral and S.P. Becerra -- 18. Circulating endothelial progenitor cells and adult vasculogenesis / S. Caballero, N. Sengupta, L.C. Shaw, and M.B. Grant -- 19. Retinopathy of prematurity / D.L. Phelps -- 20. Angiogenesis in sickle cell retinopathy / G.A. Lutty and D.S. McLeod -- 21. Diabetic retinopathy / R.N. Frank -- 22. Systems for drug delivery to the posterior segment of the eye / A.L. Weiner and D.A. Marsh -- 23. Novel therapeutic strategies for posterior segment neovascularization / D.P. Bingaman, X. Gu, A.M. Timmers, and A. Davis -- 24. Choroidal neovascularization in age-related macular degeneration- from mice to man / L. Berglin.
  • This book presents the current information on retinal and choroidal manifestations of systemic diseases from leading experts in the field and is intended for ophthalmologists, retina specialists, uveitis and ocular oncology specialists. The topics discussed in this book are not all inclusive, but include retinal and choroidal manifestations of AIDS, diffuse unilateral subacute neuroretinitis (DUSN), posterior pole manifestations of cycticercosis, toxocariasis, tuberculosis, toxoplasmosis, viral diseases, fungal diseases, endogenous endophthalmitis, sarcoidosis, diabetic retinopathy, and many more.
  • Retinal atlas 2010
    Over 5,000 illustrations of the latest imaging and research findings essential for effective diagnosis of retinal disorders populate this atlas. A unique page layout consisting of optimally positioned panoramic images, magnified photos, and histopathological specimens illustrate key manifestations, giving you the best visual display of each disease. In addition, composite images using different retinal imaging modalities, including the latest in optical coherence tomography (OCT), fluorescein angiography, indocyanine green (ICG), and fundus autofluorescence display how a disease appears in each imaging modality, allowing you to compare imaging methods and gain a better understanding of each disorder.
  • Coping with retinal degeneration : a patient's view / Gordon Cousins and James Cape -- Epidemiology of age-related macular degeneration early in the 21st century / Jie Jin Wang, Paul Mitchell, and Ronald Klein -- Leber congenital amaurosis : a hereditary childhood form of blindness and a model to elucidate retinal physiology and development / Robert K. Koenekoop -- Macular degeneration : aging changes and novel therapies / Peter E. Liggett and Alejandro J. Lavaque -- Stargardt disease : from gene discovery to therapy / Rando Allikmets -- X-linked juvenile retinoschisis / Bernhard H. F. Weber and Ulrich Kellner -- Retinal degeneration in Usher syndrome / David S. Williams -- Mouse models of retinitis pigmentosa / Bo Chang ... [et al.] -- The impact of diabetes on neuronal, glial, and vascular cells of the retina : implications for the pathogenesis of diabetic retinopathy / Sylvia B. Smith -- Statins and age-related maculopathy / Gerald McGwin, Jr. and Cynthia Owsley -- The role of drusen in macular degeneration and new methods of quantification / R. Theodore Smith and Umer F. Ahmad -- RPE lipofuscin : formation, properites, and relevance to retinal degeneration / Janet R. Sparrow -- Genetic modifiers that affect phenotypic expression of retinal diseases / Malia M. Edwards ... [et al.] -- X-linked retinal dystrophies and microtubular functions within the retina / Alan F. Wright and Xinhua Shu -- Synaptic remodeling in retinal degeneration / You-Wei Peng and Fulton Wong -- On the suppression of photoreceptor cell death in retinitis pigmentosa / Fiona Kernan ... [et al.] -- Cell-based therapies to restrict the progress of photoreceptor degeneration / Raymond D. Lund and Shaomei Wang -- Current status of IPE transplantation and its potential as a cell-based therapy for age-related macular degeneration and retinal dystrophies / Makoto Tamai -- Recent results in retinal transplantation give hope for restoring vision / Robert B. Aramant, Norman D. Radtke, and Magdalene J. Seiler -- Stem cells and retinal transplantation / Joanne Yau ... [et al.] -- Application of encapsulated cell technology for retinal degenerative diseases / Weng Tao and Rong Wen -- Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leber's congenital amaurosis / Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger -- The use of neuroprotective factors in retinal degenerations / Joyce Tombran-Tink and Colin J. Barnstable -- Carbonic anhydrase inhibitors as a possible therapy for RP17, an autosomal dominant retinitis pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response / George Rebello, Jacquie Greenberg, and Raj Ramesar -- Macular Degeneration- an addendum / Joyce Tombran-Tink and Colin J. Barnstable.
  • Part 1. AMD: Basic Mechanisms, Inflammation and Immunity -- Part 2. Neuroprotection, Drugs and Novel Protective Therapies -- Part 3. Gene Therapy -- Part 4. Blood Vessels, Angiogenesis, and Neovascularization -- Part 5. Genotype/Phenotype -- Part 6. New Animal Models of Retinal Degeneration -- Part 7. Analysis of Retinal Degeneration by Imaging and Functional Testing -- Part 8. Mechanisms of Retinal Degeneration -- Part 9. Retinal Development, Physiology, Cell and Molecular Biology.
  • Molecular genetics and candidate genes -- Diagnostic, clinical, cytopathological, and physiologic aspects of retinal degeneration -- Animal models of retinal degeneration -- Gene therapy and neuroprotection -- Usher syndrome -- Stem cells, transplantation, and retinal repair -- Induced retinal degenerations.
  • "This book will contain the proceedings of the XV International Symposium on Retinal Degeneration (RD2012). A majority of those who will speak and present posters at the meeting will contribute to this volume. The blinding diseases of inherited retinal degenerations have no treatments, and age-related macular degeneration has no cures, despite the fact that it is an epidemic among the elderly, with 1 in 3-4 affected by the age of 70. The RD Symposium will focus on the exciting new developments aimed at understanding these diseases and providing therapies for them. Since most major scientists in the field of retinal degenerations attend the biennial RD Symposia, they are known by most as the “best” and “most important” meetings in the field. The volume will present representative state-of-the-art research in almost all areas of retinal degenerations, ranging from cytopathologic, physiologic, diagnostic and clinical aspects; animal models; mechanisms of cell death; candidate genes, cloning, mapping and other aspects of molecular genetics; and developing potential therapeutic measures such as gene therapy and neuroprotective agents for potential pharmaceutical therapy."--Publisher's website.
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    Sect. I Imaging modalities: basic principles and interpretation -- Sect. II Macular diseases -- Sect. III Retinal vascular diseases -- Sect. IV Inflammatory and infectious diseases -- Sect. V Other retinal diseases -- Sect. VI Tumors -- Sect. VII Optic nerve disorders.
  • I. Pathogenesis of retinal vascular disease -- 1 Functional anatomy, fine structure and basic pathology -- 2 Retinal vascular development -- 3 Retinal angiogenesis and growth factors -- 4 Hematopoietic stem cells in vascular development and ocular neovascularization -- 5 Inflammation as a stimulus for vascular leakage and proliferation -- 6 The neuronal influence on retinal vascular pathology -- 7 Hypoxia in the pathogenesis of retinal disease -- 8 Blood retinal barrier -- 9 Retinal blood flow -- 10 Genetic approach to retinal vascular disease -- II. General concepts in the diagnosis and treatment of retinal vascular disease -- 11 A practical guide to fluorescein angiography -- 12 Optical coherence tomography in the diagnosis of retinal vascular disease -- 13 General concepts in laser treatment for retinal vascular disease -- 14 The role of photodynamic therapy in retinal vascular disease -- 15 Cryosurgery in retinal vascular disease -- 16 Vitrectomy in retinal vascular disease: surgical principles -- 17 Treatment of rubeotic secondary glaucoma -- 18 Intravitreal injections: guidelines to minimize the risk of endophthalmitis -- III. Pathology, clinical course and treatment of retinal vascular diseases -- 19 Grading of diabetic retinopathy -- 20 Retinopathy of prematurity -- 21 Vascular occlusive disease -- 22 Vascular abnormalities -- 23 Vasculopathy after treatment of choroidal melanoma -- 24 Vasculopathies with acute systemic diseases -- 25 Inflammatory vascular disease -- 26 Hypertensive retinopathies -- 27 Sickle cell retinopathy and hemoglobinopathies -- 28 Vascular tumors of the retina.
  • Anatomy and Pathologic Anatomy of Retinal Vein Occlusions -- Pathophysiology of Retinal Vein Occlusions -- Genetics of Retinal Vein Occlusions -- Classification of Retinal Vein Occlusion -- Epidemiology of Retinal Vein Occlusions -- Systemic and Ocular Associations of Retinal Vein Occlusions -- The Clinical Picture and Natural History of Retinal Vein Occlusions -- Ancillary Testing in the Management of Retinal Vein Occlusions -- Ischemia and Retinal Vein Occlusions -- Posterior Segment Neovascularization in Retinal Vein Occlusion -- Anterior Segment Neovascularization in Retinal Vein Occlusion -- Macular Edema in Retinal Vein Occlusion -- Treatment of Retinal Vein Occlusions -- Retinal Vein Occlusions in the Young -- Failed and Unadopted Treatments for Retinal Vein Occlusions -- Case Studies in Retinal Vein Occlusion.
  • Retinoblastoma 2010
  • Clinical advances and emerging treatment strategies / Timothy G. Murray -- Laboratory discoveries in retinoblastoma / Samuel K. Houston & Timothy G. Murray -- Incidence, prevalence and epidemiology / Ricardo Garza & Dan S. Gombos -- Clinical features and diagnosis of retinoblastoma / Matthew A. Cunningham & H. Culver Boldt -- Genetics of retinoblastoma and genetic counseling / Jessica Moline & Arun D. Singh -- Anesthetic considerations for children with retinoblastoma / Jacqueline Tutiven & Michael M. Vigoda -- Radiation therapy in retinoblastoma / Shiv C. Desai, Derek M. Isrow & Arnold M. Markoe -- Chemotherapy in the management of retinoblastoma / Ziad A. Khatib & Wenliang Geng -- Retinoblastoma treatment / Samuel K. Houston & Timothy G. Murray -- Treatment of extraocular and metastatic retinoblastoma / Ira J. Dunkel & Guillermo L. Chantada -- Second malignancies and other long-term effects in retinoblastoma survivors / Annette C. Moll, Jennifer van Dijk, Machteld I. Bosscha, Charlotte J. Dommering, Pim de Graaf, W. Arjenne Kors & Flora E. van Leeuwen -- Visual rehabilitation for retinoblastoma / D/ Wilkin Parke & Aaron Gold -- Retinoblastoma in the developing world / Vikas Khetan, Sabyasachi Sengupta, Fariooz P. Manjandavida & Santosh G. Honavar -- Index.
  • Anatomical Aspects of the Extra- and Retroperitoneal Space / Ahmed E. Ghazi and Jean V. Joseph -- Essential Instruments in Laparoscopic and Robotic Surgery / Ty T. Higuchi and Matthew T. Gettman -- Upper Tract Retroperitoneal Access Techniques / Ahmed E. Ghazi and Jean V. Joseph -- Laparoscopic and Robotic Adrenalectomy / Edmund Y. Ko, Richard T. Schlinkert and Mitchell R. Humphreys -- Retroperitoneoscopic Simple and Radical Nephrectomy / Guillaume Ploussard, Andras Hoznek, Laurent Salomon, Claude C. Abbou and Alexandre de la Taille -- Laparoscopic and Robotic Partial Nephrectomy / Lori M. Dulabon and Michael D. Stifelman -- Retroperitoneal Robotic Partial Nephrectomy / James R. Porter -- Laparoscopic and Robotic Mid and Distal Ureteral Reconstructive Surgery / Alireza Moinzadeh -- Robot-Assisted Laparoscopic Nephroureterectomy / Sijo J. Parekattil, Hany N. Atalah and Li-Ming Su -- Laparoscopic Pelvic Lymphadenectomy in Prostate Cancer / Evangelos Liatsikos, Minh Do, Panagiotis Kallidonis, Iason Kyriazis and Alan McNeil, et al. -- Laparoscopic Simple Prostatectomy / Xavier Cathelineau, Rafael E. Sanchez-Salas, Eric Barret, Francois Rozet and Marc Galiano, et al. -- Extraperitoneal Laparoscopic Radical Prostatectomy / Sarah P. Psutka and Douglas M. Dahl -- Robot-Assisted Extraperitoneal Laparoscopic Prostatectomy / Thomas T. Hoang, Satya B. Allaparthi and Ingolf A. Tuerk -- Laparoendoscopic Single-Site Retroperitoneal Surgery / Michael A. White and Jihad H. Kaouk -- On the Horizon / Jean V. Joseph and Hitendra R. H. Patel.
  • Chapter 1: Overview of Retrovirology -- Chapter 2: Mechanisms of Oncogenesis by Retroviruses -- Chapter 3: Deregulation of Signal Transduction Pathways by Oncogenic Retroviruses -- Chapter 4: Genetics of Host Resistance to Retroviruses and Cancer -- Chapter 5: Endogenous Retroviruses and Cancer -- Chapter 6: Retroviruses and Insights into Cancer: Retroviral Regulatory/Accessory Genes and Cancer -- Chapter 7: Cancers Induced by Piscine Retroviruses -- Chapter 8: The Immune Response to Oncogenic Retroviruses -- Chapter 9: Retrovirus-induced Immunodeficiency and Cancer.
  • Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren -- Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler -- Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens -- Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels -- Nucleotide analogs / Craig J. Hoesley -- Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters -- Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard ... [et al.] -- Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt -- Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis -- Mitochondrial toxicity and lipodystrophy / Grace McComsey -- Nevirapine / David Asmuth and Richard Pollard -- Efavirenz / Graeme J. Moyle and Brian Conway -- Delavirdine / Brian Conway -- Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich -- Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha -- New reverse transcriptase inhibitors in development / Rudi Pauwels -- Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande.
  • Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.
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  • Review of medical microbiology and immunology 2014 (13th ed.)
    12th ed., 2012 AccessMedicine
  • Review of medical physiology 2012 (24th ed.)
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    Basic sciences / Mark R. Brinker, Daniel P. O'Connor -- Pediatric orthopaedics / Todd A. Milbrandt, Daniel J. Sucato -- Sports medicine / Joshua A. Baumfeld, Jennifer A. Hart, Mark D. Miller -- Adult reconstruction / Edward J. McPherson -- Disorders of the foot and ankle / Gregory J. Roehrig, MD ... [et al.] -- Hand, upper extremity, and microvascular / Lance M. Brunton, A. Bobby Chhabra -- Spine / William C. Lauerman, Bradley Graw -- Pathology / Frank J. Frassica, Deborah A. Frassica, Edward F. McCarthy -- Rehabilitation: gait, amputations, prosthetics, orthotics / Frank A. Gottschalk -- Trauma / James P. Stannard ... [et al.] -- Anatomy / Franklin D. Shuler -- Principles of practice and statistics / S. Raymond Golish, Mark DeHart.
  • "At all levels of orthopaedic training and practice, Review of Orthopaedics , by Mark D. Miller, MD, is an ideal, state-of-the-art resource for efficient review of key orthopaedic knowledge and board prep. Thoroughly updated, this edition helps you ensure your mastery of the very latest scientific and clinical information."--Publisher's website.
  • X-ray production -- X-ray interactions -- Projection radiography I -- Projection radiography II -- Computed tomography -- Image quality -- Radiobiology/patient dosimetry -- Radiation protection -- Nuclear medicine -- Ultrasound -- Magnetic resonance.
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    [1] What people know, believe, and do about health. -- [4] Patient education. -- [6] School health education.
  • The Musculoskeletal System -- Mediators of Rheumatic Pathology -- Immunity -- Genetics -- Rheumatoid Arthritis -- Psoriatic Arthritis -- Systemic Lupus Erythematosus (SLE) -- Arthritis Associated with Calcium-Containing Crystals -- Gout -- Vasculitides -- Systemic Sclerosis and Related Syndromes -- Sjögren's Syndrome -- Behcet's Disease -- Relapsing Polychondritis -- Antiphospholipid Syndrome -- Adult Still's Disease -- Therapeutic Injections for Rheumatic Diseases -- Nonsteroidal Anti-inflammatory Drugs -- Corticosteroids -- Disease-Modifying Antirheumatic Drugs -- Cytotoxic and Immunoregulatory Agents -- Biologic Agents -- Osteoporosis -- Metabolic Bone Disorders -- Paget's Disease of Bone -- Osteonecrosis -- Hypertrophic Osteoarthropathy -- Storage and Deposition Diseases -- Amyloidoses -- The Autoinflammatory Diseases.
  • v. 1. Infectious diseases.
  • Ch. 1. DT40 gene disruptions: a how-to for the design and the construction of targeting vectors / Hiroshi Arakawa and Jean-Marie Buerstedde -- Ch. 2. Immunoglobulin gene conversion or hypermutation: That's the question / Jean-Marie Buerstedde and Hiroshi Arakawa -- Ch. 3. Genome resources for the DT40 community / Randolph B Caldwell and Andrzej M. Kierzek -- Ch. 4. Chromosome engineering in DT40 cells and mammalian centromere function / William R.A. Brown ... [et al.] -- Ch. 5. Function of recQ family helicase in genome stability / Masayuki Seki, Shusuke Tada and Takemi Enomoto -- Ch. 6. Genetic analysis of apoptotic execution / Sandrine Ruchaud ... [et al.] -- Ch. 7. The DT40 system as a tool for analyzing kinetochore assembly / Masahiro Okada, Tesuya Hori and Tatsuo Fukagawa -- Ch. 8. Analysing the DNA damage and replication checkpoints in DT40 cells / Michael D Rainey, George Zachos, and David AF Gillespie -- Ch. 9. Using DT40 to study clathrin function / Frank R. Wettey and Antony P. Jackson -- Ch. 10. Genetic analysis OF B cell signaling / Hisaaki Shinohara and Tomohiro Kurosaki -- Ch. 11. DT40 mutants: a model to study transcriptional regulation of B cell development and function / Jukka Alinikula, Olli Lassila and Kalle-Pekka Nera -- Ch. 12. Transcription and RNA processing factors play complex roles IN DT40 cells / Stephanie Bush and James L. Manley -- Ch. 13. Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions / Hidehiko Kikuchi ... [et al.] -- Ch. 14. Analysis of gene expression, copy number and palindrome formation with a DT40 enriched cDNA Microarray / Paul E. Neima ... [et al.] -- Ch. 15. Analysis of DNA replication damage bypass and its role in immunoglobulin repertoire development / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 16. The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 17. Calcium signaling, ion channels and more / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- Ch. 18. Phenotypic analysis of cellular responses to DNA damage / Helfrid Hochegger and Shunichu Takeda -- Ch. 19. ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells / Ken-ichi Yamamoto, Masahiko Kobayashi and Hiroko Shimizu -- METHOD 1. Stable transfection of DT40 / Julian E. Sale -- METHOD 2. Basic cell culture conditions / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 3. Excision of floxed-DNA sequences by transient induction of Mer-Cre-Mer / Hiroshi Arakawa -- METHOD 4. Immunoglobulin gene conversion and hypermutation assay by FACS / Hiroshi Arakawa -- METHOD 5. Target screening by PCR / Hiroshi Arakawa -- METHOD 6. Mitotic index determination by flow cytometry / David AF Gillespie and Mark Walker -- METHOD 7. Centrifugal elutriation as a means of cell cycle phase separation and synchronization / David AF Gillespie and Catarina Henriques -- METHOD 8. Preparation of genomic DNA for microarray-based comparative genome hybridization / Robert Kimmel, Amalia Icreverzi, Paul Neiman -- METHOD 9. Analysis of cellular Mg2+ in DT40 cells / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- METHOD 10. Transient transfection of DT40 / Roger Franklin & Julian E. Sale -- METHOD 11. Retroviral transduction of DT40 / Felix Randow & Julian E. Sale -- METHOD 12. Colony survival assay / Laura. J. Simpson & Julian E. Sale -- METHOD 13. Subcloning DT40 by limiting dilution / Jean-Marie Buerstedde -- METHOD 14. Subnuclear immunofluorescence / Dávid Szüts & Julian E. Sale -- METHOD 15. Sister chromatid exchange assay / Laura J. Simpson & Julian E. Sale -- METHOD 16. 2D cell cycle analysis / Roger Franklin & Julian E. Sale -- METHOD 17. Purification of tap-tagged proteins by two-step pull down from DT40 cells / Hiroyuki Kitao and Minoru Takata -- METHOD 18. Synchronization of cells / Eiichiro Sonoda -- METHOD 19. Tranfection of DT40 cells / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 20. Luciferase reporter assay / Frank R. Wettey and Antony P. Jackson -- METHOD 21. Indirect immunofluorescence microscopy / Frank R. Wettey and Antony P. Jackson -- METHOD 22. Quantification of receptor-mediated endocytosis / Frank R. Wettey and Antony P. Jackson -- METHOD 23. Measurement of DNA synthesis and strand breaks using alkaline sucrose density gradient centrifugation / Kouichi Yamada and Jun Takezawa -- METHOD 24. Fractionation of nuclear and cytoplasmic proteins from DT40 cell lines / Yan-Dong Wang and Randolph B Caldwell.
  • Although anterior cruciate ligament (ACL) reconstruction has a high success rate, a substantial number of patients are left with unsatisfactory results. Revision ACL Reconstruction: Indications and Technique provides detailed strategies for planning and executing revision ACL reconstructions. Concise chapters by a leading group of international orthopedic surgeons cover the diagnosis of failed ACL reconstruction, patient evaluation, preoperative planning for revision ACL surgery, and complex technical considerations.
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  • This report is being released in conjunction with the Robert Wood Johnson Foundation's Care About Your Care initiative, which is devoted to improving care transitions when people leave the hospital. It looks at the issue of readmissions in two ways: by the numbers and through the eyes of the people who live them.
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  • The summary of the published clinical guideline on Rheumatoid arthritis. It links to the published guidance and key documents.
  • This reference provides current insights into the etiology, diagnosis and management of rheumatoid arthritis. Leading international authorities in RA examine all of the latest scientific and clinical developments in understanding and managing this challenging disease, including new concepts in pathogenesis, epidemiology, risk factors, imaging, clinical outcomes and treatment. It provides the latest understanding of the pathogenesis of rheumatoid arthritis, including molecular pathways/mechanisms, and genetic and environmental factors that instigate and drive the disease. Includes comprehensive coverage of clinical features of rheumatoid arthritis including articular, peri-articular and extra-articular manifestations, comorbidities, and outcome measures-disease activity, joint assessment, imaging, and more-for expert diagnosis and monitoring of disease progression.

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