Lane Medical Library

Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.

Volume 2 has country-by-country analysis.

The Food and Agriculture Organization of the United Nations and the World Health Organization convened a Joint Expert Consultation on the Risks and Benefits of Fish Consumption from 25 to 29 January 2010. The tasks of the Expert Consultation were to review data on levels of nutrients (long-chain omega-3 fatty acids) and specific chemical contaminants (methylmercury and dioxins) in a range of fish species and to compare the health benefits of fish consumption and nutrient intake with the health risks associated with contaminants present in fish. The Expert Consultation drew a number of conclusions regarding the health benefits and health risks associated with fish consumption and recommended a series of steps that Member States should take to better assess and manage the risks and benefits of fish consumption and more effectively communicate these risks and benefits to their citizens. The output of the Expert Consultation is a framework for assessing the net health benefits or risks of fish consumption that will provide guidance to national food safety authorities and the Codex Alimentarius Commission in their work on managing risks, taking into account the existing data on the benefits of eating fish. The Expert Consultation concluded the following: Consumption of fish provides energy, protein and a range of other important nutrients, including the long-chain n-3 polyunsaturated fatty acids (LCn3PUFAs). Eating fish is part of the cultural traditions of many peoples. In some populations, fish is a major source of food and essential nutrients. Among the general adult population, consumption of fish, particularly fatty fish, lowers the risk of mortality from coronary heart disease. There is an absence of probable or convincing evidence of risk of coronary heart disease associated with methylmercury. Potential cancer risks associated with dioxins are well below established coronary heart disease benefits from fish consumption. When comparing the benefits of LCn3PUFAs with the risks of methylmercury among women of childbearing age, maternal fish consumption lowers the risk of suboptimal neurodevelopment in their offspring compared with the offspring of women not eating fish in most circumstances evaluated. At levels of maternal exposure to dioxins (from fish and other dietary sources) that do not exceed the provisional tolerable monthly intake (PTMI) of 70 pg/kg body weight established by JECFA (for PCDDs, PCDFs and coplanar PCBs), neurodevelopmental risk for the fetus is negligible. At levels of maternal exposure to dioxins (from fish and other dietary sources) that exceed the PTMI, neurodevelopmental risk for the fetus may no longer be negligible. Among infants, young children and adolescents, the available data are currently insufficient to derive a quantitative framework of the health risks and health benefits of eating fish. However, healthy dietary patterns that include fish consumption and are established early in life influence dietary habits and health during adult life.

The report includes listings of substances, divided into two categories: known human carcinogens and substances reasonably anticipated to be human carcinogens.

Methodologies for staining and visualization of [beta]-galactosidase in mouse embryos and tissues / Siobhan Loughna and Deborah Henderson -- Immunohistochemical detection of [beta]-galactosidase or green fluorescent protein on tissue sections / Philip A. Seymour and Maike Sander -- Detection of reporter gene expression in murine airways / Maria Limberis, Peter Bell, and James M. Wilson -- Three-dimensional analysis of molecular signals with episcopic imaging techniques / Wolfgang J. Weninger and Timothy J. Mohun -- Fluorescent proteins for cell biology / George H. Patterson -- Detection of GFP during nervous system development in Drosophila melanogaster / Karin Edoff, James S. Dods, and Andrea H. Brand -- Autofluorescent proteins for flow cytometry / Charles G. Bailey and John E. J. Rasko -- Fluorescent protein reporter systems for single-cell measurements / Steven K. Dower, Eva E. Qwarnstrom, and Endre Kiss-Toth -- Subcellular imaging of cancer cells in live mice / Robert M. Hoffman -- Noninvasive imaging of molecular events with bioluminescent reporter genes in living subjects / Pritha Ray and Sanjiv Sam Gambhir -- Green fluorescent protein as a tracer in chimeric tissues : the power of vapor fixation / Harald Jockusch and Daniel Eberhard.

Perspectives on reproduction and life history in baboons / Larissa Swedell & Steven R. Leigh -- Infant mortality, paternity certainty, and female reproductive strategies in hamadryas baboons / Larissa Swedell & Julian Saunders -- Female behavioral strategies of hybrid baboons in the Awash National Park, Ethiopia / Jacinta C. Beehner & Thore J. Bergman -- Hybrid baboons and the origins of the hamadryas male reproductive strategy / Thore J. Bergman -- The social and ecological flexibility of Guinea baboons : implications for Guinea baboon social organization and male strategies / Anh Galat-Luong, Gérard Galat & Suzanne Hagell -- Social organization, reproductive systems, and mediation of baboon endogenous virus (BaEV) copy number in gelada, hamadryas, and other Papio baboons / Monica Uddin, Jane E. Phillips-Conroy & Clifford J. Jolly -- Reproduction, mortality, and female reproductive success in chacma baboons of the Okavango Delta, Botswana / Dorothy L. Cheney ... [et al.] -- Maternal characteristics and offspring growth in chacma baboons : a life-history perspective / Sara E. Johnson -- Whose life is it anyway? Maternal investment, developmental trajectories, and life history strategies in baboons / Louise Barrett, S. Peter Henzi & John E. Lycett -- Ontogeny, life history, and maternal investment in baboons / Steven R. Leigh & Robin M. Bernstein -- Testicular size, developmental trajectories, and male life history strategies in four baboon taxa / Clifford J. Jolly & Jane E. Phillips-Conroy -- The evolutionary past and the research future : environmental variation and life history flexibility in a primate lineage / Susan C. Alberts & Jeanne Altmann.

Reproductive toxicology is a complex subject dealing with three components-parent, placenta, and fetus-and the continuous changes that occur in each. Reproductive and Developmental Toxicology is a comprehensive and authoritative resource providing the latest literature enriched with relevant references describing every aspect of this area of science. It addresses a broad range of topics including nanoparticles and radiation, gases and solvents, smoking, alcohol and drugs of abuse, food additives, nutraceuticals and pharmaceuticals, and metals, among others. With a special focus on placental toxicity, this book is the only available reference to connect the three key risk stages, and is the only resource to include reproductive and developmental toxicity in domestic animals, fish, and wildlife.

Basis for molecular reproductive biology -- Introduction to the molecular organization of the endocrine/reproductive system -- Extracellular signaling receptors -- Molecules that transmit information into the cell: the intracellular signaling pathways -- Introduction to molecular biology: structure and function of the macromolecules of genetic information -- Regulation of gene expression -- Molecular basis of abnormal phenotype -- Tools of molecular reproductive biology -- Recombinant DNA technology -- Techniques for DNA analysis -- Analyzing gene expression -- DNA microarray analysis -- Computer assisted analysis of genes -- Introduction to gene therapy -- Molecular regulation of reproductive hormones -- GnRH-GnRH-receptor system in the mammalian female reproductive tract -- FSH: one hormone with multiple forms, or a family of multiple hormones -- FSH receptor: one receptor with multiple forms or a family of receptors -- Regulation of the early steps in gonadal steroidogenesis -- Prostaglandins and their mechanisms of action in the cyclic ovary -- Androgens: molecular basis and related disorders -- Leptin as a reproductive hormone -- Neurosteroids and sexual behavior and reproduction -- Molecular regulation of the reproductive organs and tissues -- Autocrine and paracrine regulation of the ovary -- Ovarian endocrine activity: role of follistatin, activin, and inhibin -- Hormonal and molecular regualtion of the cytochrome P450 aromatase gene expression in the ovary -- Epigenetic mechanisms of ovarian gene regulation -- Ovarian function and failure: the role of the oocyte and its molecules -- Molecular control of corpus luteum function -- Molecular landscape of spermatogonial stem cell renewal, meiotic sex chromosome inactivation, and spermatic head shaping.

Characteristics of a successful R.E.I. clinic and laboratory -- Assisted reproductive technology practice management -- Collaboration within the reproductive endocrinology and infertility practice: integration of laboratory and clinic operations -- Informed consent in advanced reproductive technology -- Reproductive laboratory regulations, certifications and reporting systems -- Successfully integrating the FDA regulations into your practice -- Psychosocial consequences of infertility and treatment -- A live baby or your money back: the marketing of in vitro fertilization procedures -- Ovulation: a molecular view -- Clinical evaluation of female factor infertility -- Polycystic ovary syndrome -- The current status for Metformin use in reproductive medicine -- Clinical aspects of endometriosis -- Common endocrinopathies in reproductive endocrinology -- Acquired uterine factors and infertility -- Mullerian (paramesonephric) anomalies and associated Wolffian (mesonephric) duct malformations -- Recurrent miscarriage -- Laparoscopy in the diagnosis and treatment of female infertility -- Turner syndrome -- Errors in chromosome segregation during oogenesis and early embryogenesis -- An overview of sperm production -- Meiotic recombination and errors during spermatogenesis -- Clinical evaluation and treatment of male factor infertility -- Semen analysis: essentials for the clinician -- Sperm capacitation, the acrosome reaction, and fertilization -- Advanced tests of sperm function -- Genetic testing of male infertilityVaricocele and male infertility -- Sperm retrieval techniques -- The clinical utility of the evaluation of sperm chromatin -- Artificial insemination: intrauterine insemination -- Sperm preparation for artificial insemination -- Sperm banking, donation, and transport in the age of assisted reproduction: federal and state regulation -- Reproductive treatment of HIV-1 discordant couples -- Ovulation induction -- Transvaginal sonography in reproductive endocrinology and infertility -- Establishing the IVF laboratory: a systems view -- Preparation and selection of sperm for IVF and ICSI -- The genetic and epigenetic contributions of sperm to early embryogenesis -- Micromanipulation of human oocytes and embryos: applications of intracytoplasmic sperm injection and assisted hatching in infertility treatment -- Embryo culture techniques -- In-vitro maturation of human oocytes -- Integrating preimplantation genetic diagnosis into the ART laboratory -- Evaluation and selection of preimplantation embryos for transfer -- Embryo transfer in IVF: evidence-based clinical practice -- Cryopreservation of human oocytes and embryos -- Preserving fertility -- Ovarian hyperstimulation syndrome -- Pregnancy outcomes in infertile couples -- The impact of complementary medicine on in-vitro fertilization -- Designing a clinical research infrastructure -- Integrating research into a clinical practice -- Research regulations: the role of the Institutional Review Board -- Technology transfer and its role in the practice of reproductive endocrinology and infertility -- The environment and reproduction: endocrine disruption, reproductive impairment, and epigenetics.

Foundations of reproductive epidemiology -- Environments in reproductive epidemiology -- Research process in reproductive epidemiology -- Surveillance in reproductive epidemiology -- Descriptive reproductive health indicators -- Study designs in reproductive epidemiology -- Causal inference in reproductive epidemiology -- Nutrition and reproductive health -- Contraception and reproductive health -- Mercury, lead, environmental estrogens, and reproductive health -- Psychosocial factors and reproductive health -- Early childbearing : trends and consequences -- Cancer risk associated with early and late maternal age at first birth.

Principles of cancer treatment: impact on reproduction -- Fertility preservation options for females -- Options for fertility preservation in men and boys with cancer -- Contraception and cancer treatment in young persons -- Sexual health during cancer treatment -- Unique reproductive concerns of young women with breast cancer -- Pregnancy and cancer -- Preimplantation genetic diagnosis for hereditary cancers -- Non-traditional family building planning -- Parenting with cancer I: developmental perspective, communication, and coping -- Parenting with cancer II: parenting at different stages of illness -- Pediatric oncology and reproductive health -- Institutional approaches to implementing fertility preservation for cancer patients -- Patient provider communication and reproductive health -- Fertility preservation in cancer patients: ethical considerations -- Legal issue and of assisted reproductive technologies.

Introduction --Environmental Impact on Reproductive Health, Recent Trends and Developments /P. Nicolopoulou-Stamati and N.J. Lelos.Section 1: The Link Between Reproductive Health and Environment. --Epidemiological Studies on the Relationship between Semen Quality and Environmental Chemicals: Historic and Contemporary Compounds /R. Hauser and J.D. Meeker --Environment and Fertility /P. Saldiva.Section 2: Reproductive Health Effects. --Male Reproductive Status and its Relationship with Man-Made, Hormone-Disrupting Substances: Studies In Flanders, Belgium /W. Dhooge, F. Eertmans, A. Mahmoud, and F. Comhaire --Potential Impact of the Environment on the Male Reproductive Function: The Example Of Cryptorchidism /E. Huyghe, R. Mieusset and P.F. Thonneau --Advanced Glycation End Products in Polycystic Ovarian Syndrome /E. Diamanti-Kandarakis, C. Piperi, and P. Nicolopoulou-Stamati --Oocytes and Ovarian Follicles as Targets of Endocrine Disrupters: Consequences for Reproductive Health /F. Gandolfi, T.A.L. Brevini, and F. Cillo.Section 3: Pollutants And Exposure. --Non-Pesticide Endocrine Disrupters and Reproductive Health /S. Corsolini --Medical Drugs Impairing Fertility /N. Pandiyan --Impact of Air Pollution on Reproductive Health in Northern Bohemia /J. Rubes, S.G. Selevan, R.J. Sram, D.P. Evenson, and S.D. Perreault.Section 4: Policy Instruments And Issues. --Pesticides as Endocrine Disrupters: Identification of Hazards for Female Reproductive Function /M. Rescia and A. Mantovani --Assessment of Fertility and Other Health Impacts for Selected Pollutants in Flanders: Opportunities and Limitations /J. De Wit, A. Verspecht and L. Hens --Problems in Assessing Low Dose Effects of Endocrine Disrupters /A. Gies --Getting the Message Across - WWFs and ISDEs Perspectives on Communication Strategies to Reduce Exposures to Hazardous Chemicals /G. Lyons and P. Illig --Environmental Ethics and Fertility in Early Cultures and The Industrial Age /A. Katsivelaki and C.E. Sekeris.Section 5: Regional Aspects. --Reproductive Health Problems in the Greater Athens Area /D.A. Adamopoulos and E. Koukkou --Environment and Reproductive Health in Bulgaria /S. Stoyanov and E. Terlemesian.

About these guidelines -- Introduction -- Indicators-an overview in the context of global monitoring -- Generation, interpretation and analysis of the shortlisted national reproductive health indicators -- 1. Total fertility rate -- 2. Contraceptive prevalence -- 3. Maternal mortality ratio -- 4. Antenatal care coverage -- 5. Births attended by skilled health personnel -- 6. Availability of basic essential obstetric care -- 7. Availability of comprehensive essential obstetric care -- 8. Perinatal mortality rate -- 9. Prevalence of low birth weight -- 10. Prevalence of positive syphilis serology in pregnant women -- 11. Prevalence of anaemia in women -- 12. Percentage of obstetric and gynaecological admissions owing to abortion -- 13. Reported prevalence of women with genital mutilation -- 14. Prevalence of infertility in women -- 15. Reported incidence of urethritis in men -- 16. Prevalence of HIV infection in pregnant women -- 17. Knowledge of HIV-related preventive practices -- Annex 1. Millennium Development Goals and associated targets -- Annex 2. The selection criteria for the shortlist of indicators.

"This overview outlines the statutory background for WHO's research, identifies the milestones in health research over five decades, and discusses issues of both process and programs. This report also includes accounts of regional efforts in health research"--Publisher's description.African region; Eastern Mediterranean region; European region; South East Asia region; Western Pacific region; Pan American Health Organization

Introduction to research / Carol Noll Hoskins and Carla Mariano -- The research question / Carol Noll Hoskins and Carla Mariano -- A review of the literature: using online and print sources / Barbara Carty, Susan Kaplan Jacobs, Carol Noll Hoskins, and Carla Mariano -- Theoretical and conceptual frameworks / Carol Noll Hoskins and Carla Mariano -- Research designs / Carol Noll Hoskins and Carla Mariano -- Sampling methods: basic issues and concepts / Joseph Giacquinta and Carla Mariano -- Principles of measurement / Carol Noll Hoskins -- Development of quantitative methods / Carol Noll Hoskins -- Data analysis and interpretation / Carol Noll Hoskins and Carla Mariano -- Product of the inquiry: the research report / Carol Noll Hoskins and Carla Mariano -- Guide to critique of quantitative research with examples and practice studies / Carol Noll Hoskins -- Guide to critique of qualitative research with examples and practice studies / Carla Mariano.

Topics include self-Management, self-Efficacy, health Status, and some diabetes-specific scales.

Ethical and practice issues in qualitative research / Frances Sheldon and Anita Sargeant -- Evaluating qualitative research / Michelle Crossley -- Mixed methods for evaluation research / Christine Ingleton and Sue Davies -- Ethnography / Jane Seymour -- Documentary analysis and policy / Margaret O'Connor -- How to develop a research question / Laura Kelly and Patrick Stone -- Writing a research proposal / Chris Todd -- How to gain research ethics approval / Peter Speck -- How to use a statistician / Malcolm Campbell -- How to write a paper / Julia M. Addington-Hall.Principles of designing clinical trials in palliative care / Michael I. Bennett -- Ethical and practical issues in designing and conducting clinical trials in palliative care / Yolanda Zuriarrain Reyna, Michael I. Bennett, and Eduardo Bruera -- Survey design / Julia M. Addington-Hall -- Survey research : methods of data collection, questionnaire design, and piloting / Julia M. Addington-Hall -- Experimental and quasi-experimental designs / Massimo Costantini and Irene J. Higginson -- Outcome measurement / Irene J. Higginson and Richard Harding -- Systematic reviews / Marjolein Gysels and Irene J. Higginson -- Qualitative methods of data collection and analysis / Sheila Payne --

Part One: Beginning grantsmanship -- 1. The NIH and other sources of research support -- 2. A strong proposal -- 3. Proposal review -- 4. The R01 research grant -- 5. The abstract and specific aims -- 6. Background and significance -- 7. Preliminary studies -- 8. Research design and methods -- 9. The budget -- 10. Biographical sketch, research support, and resources -- 11. Human subjects -- 12. Animal subjects -- 13. Consortiums, contracts, consultants, and collaborators -- 14. Literature cited and appendixes -- 15. Revision of an unfunded proposal -- 16. Competing renewal of R01 projects (progress reports) -- 17. Proposal submission and supplementary materials -- 18. Your first grant award (R, F, or K) -- 19. Advice for beginners in academia. -- Part two: Advanced grantsmanship -- 20. Small business grants -- 21. Program project grants (P01) -- 22. Center grants -- 23. Construction grants -- 24. T32 institutional research training program grants -- 25. Instrumentation grants -- Appendix -- A. Information sources: private foundation and government web sites, and study section contacts -- B. Summary statements, reviewer comments, assignment, award, and triage letters -- C. Examples of figures from preliminary data -- D. Examples of design format -- E. Instructions to reviewers concerning human subjects -- F. Suggested reading.

1. Violence against women as a health and development issue -- 2. Ethical considerations for researching violence against women -- 3. Developing a research strategy -- 4. Quantitative approaches to research -- 5. Qualitative approaches to research -- 6. The challenge of defining and measuring violence in quantitative research -- 7. Developing a sampling strategy -- 8. Tools for collecting quantitative data -- 9. Tools for collecting qualitative data -- 10. Building your research team -- 11. In the field -- 12. Analyzing quantitative data -- 13. Analyzing qualitative data -- 14. From research to action -- Appendix 1. The WHO Violence Against Women Instrument -- Appendix 2. Training exercises for interviewers -- Appendix 3. Suggested resources.

Resilience: definitions, ambiguities, and applications -- Successful aging and resilience: applications for public health and health care -- Resilience and personality disorders in older age -- What do we know about resilience in older adults?: an exploration of some facts, factors, and facets -- Psychological resilience -- Physiological resilience -- Using the arts to promote resiliency among persons with dementia and their caregivers -- Promoting worker resilience over the lifecourse -- Resilience in aging: cultural and ethnic perspectives -- Civic engagement: policies and programs to support a resilient aging society -- Strengthened by the spirit: religion, spirituality, and resilience through adulthood and aging -- Resilience in chronic illness -- The relationship between resilience and motivation -- The association between resilience and survival among Chinese elderly -- Fostering resilience in dementia through narratives: contributions of multimedia technologies -- Building resilience in mild cognitive impairment and early-stage dementia: innovative approaches to intervention and outcome evaluation -- African-American caregivers finding resilience through faith -- The age-friendly New York City project: an environmental intervention to increase aging resilience -- Promoting resilience in small-scale, homelike residential care settings for older people with dementia: experiences from the Netherlands and the United States -- A geriatric mobile crisis response team: a resilience-promoting program to meet the mental health needs of community-residing older people -- Optimizing resilience in the 21st century -- Resilience in the workplace: job conditions that buffer negative attitudes toward older workers.

(Publisher-supplied data) Historically, the diagnosis of deafness in a child has been closely associated with profound disability, including such typical outcomes as unmet potential and a life of isolation. A major shift away from this negative view has led to improved prospects for deaf children. Resilience in Deaf Children emphasizes not only the capability of deaf individuals to withstand adversity, but also their positive adaptation through interactions with parents, peers, school, and community. In this engaging volume, leading researchers and professionals pay particular attention to such issues as attachment, self-concept, and social competence, which are crucial to the development of all young people. In addition, the volume offers strategies for family members, professionals, and others for promoting the well-being of deaf children and youth. Coverage includes: Attachment formation among deaf infants and their primary caregivers.Deaf parents as sources of positive development and resilience for deaf infants.Enhancing resilience to mental health disorders in deaf school children.Strength-based guidelines for improving the developmental environments of deaf children and youth.Community cultural wealth and deaf adolescents resilience.Self-efficacy in the management of anticipated work-family conflict as a resilience factor among young deaf adults.Resilience in Deaf Children is essential reading for researchers, clinicians, and graduate students in clinical child, school, and developmental psychology as well as for allied researchers and professionals in such disciplines as school counseling, occupational therapy, and social work.

An approach to ethical dilemmas in patient care -- Overview of ethical guidelines -- Informed consent -- Promoting the patient's best interests -- Confidentiality -- Avoiding deception and nondisclosure -- Keeping promises -- An approach to decisions about clinical interventions -- Futile interventions -- Decision-making capacity -- Refusal of treatment by competent, informed patients -- Standards for decisions when patients lack decision-making capacity -- Surrogate decision making -- Persistent disagreements over care -- Confusing ethical distinctions -- Ethics committees and case consultations -- Do not attempt resuscitation orders -- Tube and intravenous feedings -- Physician-assisted suicide and active euthanasia -- The persistent vegetative state -- Determination of death -- Legal rulings on life-sustaining interventions -- Overview of the doctor-patient relationship -- Refusal to care for patients -- Gifts from patients to physicians -- Sexual contact between physicians and patients -- Secret information about patients -- Clinical research -- Overview of conflicts of interest -- Bedside rationing of health care -- Incentives for physicians to increase services -- Incentives for physicians to decrease services -- Gifts from drug companies -- Disclosing errors -- Impaired colleagues -- Ethical dilemmas students and house staff face -- Ethical issues in pediatrics -- Ethical issues in surgery -- Ethical issues in obstetrics and gynecology -- Ethical issues in psychiatry -- Ethical issues in organ transplantation -- Testing for genetic conditions -- Ethical issues in public health emergencies.

Introduction to patient assessment / Robert L. Wilkins, Philip M. Gold -- Introduction to respiratory failure / Robert L. Wilkins, James R. Dexter -- Asthma / Robert L. Wilkins, Philip M. Gold -- Chronic obstructive pulmonary disease / Robert L. Wilkins, Philip M. Gold -- Cystic fibrosis / N. Lennard Specht -- Hemodynamic monitoring and shock / Robert L. Wilkins, James R. Dexter -- Pulmonary thromboembolic disease / James R. Dexter -- Heart failure / Arthur B. Marshak, George H. Hicks -- Smoke inhalation injury and burns / George H. Hicks, Carl A. Eckrode -- Near drowning / William F. Galvin -- Acute respiratory distress syndrome / Robert L. Wilkins, James R. Dexter -- Chest trauma / George H. Hicks, Carl A. Eckrode -- Postoperative atelectasis / Thomas P. Malinowski -- Interstitial lung disease / N. Lennard Specht -- Neuromuscular diseases / N. Lennard Specht, Rebekah Bartos Specht -- Bacterial pneumonia / Robert L. Wilkins, James R. Dexter -- Pneumonia in the immunocompromised patient / Philip M. Gold, N. Lennard Specht -- Sleep disordered breathing / Enrique Gil -- Tuberculosis / James R. Dexter, Robert L. Wilkins -- Lung cancer / Gregory A.B. Cheek -- Appendix A: Normal laboratory values -- Appendix B: GOLD standards for diagnosing and treating patients with COPD -- Appendix C: Websites useful for learning information about the diagnosis and treatment of lung diseases.

Structure and function: how the architecture of the lung subserves its function -- Ventilation: how gas gets to the alveoli -- Diffusion: how gas gets across the blood-gas barrier -- Blood flow and metabolism: how the pulmonary circulation removes gas from the lung and alters some metabolites -- Ventilation-perfusion relationships: how matching of gas and blood determines gas exchange -- Gas transport by the blood: how gases are moved to the peripheral tissues -- Mechanics of breathing: how the lung is supported and moved -- Control of ventilation: how gas exchange is regulated -- Respiratory system under stress: how gas exchange is accomplished during exercise, at low and high pressures, and at birth -- Tests of pulmonary function: how respiratory physiology is applied to measure lung function.

Respiratory physiology -- Disorders of the pediatric chest -- Respiratory monitoring -- Bronchoscopy in the pediatric intensive care unit -- Acute lung injury and acute respiratory distress syndrome -- Mechanical ventilation -- Ventilator-induced lung injury -- Prone positioning -- High-frequency oscillatory ventilation -- Pulmonary surfactant: biology and therapy -- Nitric oxide -- Extracorporeal life support for children with acute respiratory failure -- Diseases of the upper respiratory tract -- Congenital airway and respiratory tract anomalies -- Status asthmaticus -- Bronchiolitis -- Pneumonia and empyema -- Pediatric lung transplantation -- Neuromuscular respiratory failure -- Diseases of the pulmonary vascular system.

Scientific research and ethics -- Ethical decision making -- Data acquisition and management -- Mentoring and collaboration -- Collaboration between academia and private industry -- Authorship -- Publication and peer review -- Misconduct in research -- Intellectual property -- Conflicts of interest and scientific objectivity -- The use of animals in research -- The protection of human subjects in research -- Protecting vulnerable human subjects in research -- Genetics, cloning, and stem cell research -- International research.

Emergency Medical Services for Children / Derek S. Wheeler and Tom LeMaster -- Pediatric Cardiopulmonary Resuscitation / Vinay M. Nadkarni and Robert A. Berg -- Supplemental Oxygen and Bag-Valve-Mask Ventilation / Patricia Abboud, Jennifer Raake, and Derek S. Wheeler -- Assessment and Management of the Pediatric Airway / Derek S. Wheeler, James P. Spaeth, Renuka Mehta, Suriyanarayana P. Hariprakash, and Peter N. Cox -- Vascular Access / Jennifer Kaplan and Richard J. Brilli -- Shock: An Overview / Joseph A. Carcillo, Derek S. Wheeler, Neil W. Kooy, and Thomas P. Shanley -- Acute Respiratory Failure / Jennifer L. Turi and Ira M. Cheifetz -- Pediatric Transport Medicine / Derek S. Wheeler and W. Bradley Poss -- Withdrawal of Life Support / Kathleen L. Meert and Ashok P. Sarnaik -- Brain Death / Sam D. Shemie -- The Pathophysiology of Brain Death and Care of the Potential Organ Donor / Sam D. Shemie.

What is heart failure and what are the treatment options? Complex questions / Jonathan Sackner-Bernstein -- Cardiac resynchronization therapy / David L. Hayes -- Electrocardiogram interpretation with biventricular pacing devices / Samuel J. Asirvatham -- Biventricular device implantation / Samuel J. Asirvatham -- Optimization of biventricular devices / Samuel J. Asirvatham, David L. Hayes -- What echocardiography may offer cardiac resynchronization therapy / Theodore P. Abraham -- Implantable defibrillators and combined ICD-resynchronization therapy in patients with heart failure / Paul J. Wang, David L. Hayes -- Future of cardiac resynchronization / David L. Hayes ... [et al.].

Explanations, philosophy and theory in health inequalities research: towards a critical realist approach -- Values and social epidemiologic research -- Population-based data and community empowerment -- Differences that matter -- Context -- Place-based stress and chronic disease: a systems view of environmental determinants -- How goes the neighbourhood? Rethinking neighbourhoods and health research in social epidemiology -- Application of two schools of social theory to neighbourhood, place and health research -- Locating politics in social epidemiology -- Research tools in action -- Structural violence and structural vulnerability within the risk environment: theoretical and methodological perspectives for a social epidemiology of HIV risk among injection drug users and sex workers -- Realist review methods for complex health problems -- Addressing health equalities in social epidemiology: learning from evaluation(s) -- Making a difference -- Knowledge translation and social epidemiology: taking power, politics and values seriously -- Community-academic partnerships and social change -- Producing more relevant evidence: applying a social epidemiology research agenda to public health practice.

v. 1. Basic science, inherited retinal disease, and tumors -- v. 2. Medical retina -- v. 3. Surgical retina.

1.Cellular and molecular mechanisms of retinal angiogenesis /M.A. Behzadian et. al --2.Animal models of choroidal neovascularization /M.L. Clark, J.A. Fowler, and J.S. Penn --3.Rodent models of oxygen-induced retinopathy /S.E. Yanni, G.W. McCollum, and J.S. Penn --4.Animal models of diabetic retinopathy /T.S. Kern --5.Neovascularization in models of branch retinal vein occlusion /R.P. Danis and D.P. Bingaman --6.Vasculogenesis and angiogenesis in formation of the human retinal vasculature /T. Chan-Ling --7.IGF-1 and retinopathy /L.E.H. Smith --8.Hypoxia and retinal neovascularization /B.A. Berkowitz --9.Hypoxia inducible Factor-1 and VEGF induction /A. Madan --10.The role of protein kinase C in diabetic retinal vascular abnormalities /J.K. Sun and G.L. King --11.Eph receptor tyrosine kinases: modulators of angiogenesis /J. Chen, D. Brantley-Siders, and J.S. Penn --12.Adenosine in retinal vasculogenesis and angiogenesis in oxygen-induced retinopathy /G.A. Lutty and D.S. McLeod --13.The regulation of retinal angiogenesis by cyclooxygenase and the prostanoids /G.W. McCollum and J.S. Penn --14.Extracellular proteinases in ocular angiogenesis /A. Das and P.G. McGuire --15.Oxygen-independent angiogenic stimuli /J.M. Holmes, D.A. Leske, and W.L. Lanier --16.Growth factor synergy in angiogenesis /A.V. Ljubimov --17.Pigment epithelium derived factor and angiogenesis /J. Amaral and S.P. Becerra --18.Circulating endothelial progenitor cells and adult vasculogenesis /S. Caballero, N. Sengupta, L.C. Shaw, and M.B. Grant --19.Retinopathy of prematurity /D.L. Phelps --20.Angiogenesis in sickle cell retinopathy /G.A. Lutty and D.S. McLeod --21.Diabetic retinopathy /R.N. Frank --22.Systems for drug delivery to the posterior segment of the eye /A.L. Weiner and D.A. Marsh --23.Novel therapeutic strategies for posterior segment neovascularization /D.P. Bingaman, X. Gu, A.M. Timmers, and A. Davis --24.Choroidal neovascularization in age-related macular degeneration- from mice to man /L. Berglin.

Coping with retinal degeneration : a patient's view / Gordon Cousins and James Cape -- Epidemiology of age-related macular degeneration early in the 21st century / Jie Jin Wang, Paul Mitchell, and Ronald Klein -- Leber congenital amaurosis : a hereditary childhood form of blindness and a model to elucidate retinal physiology and development / Robert K. Koenekoop -- Macular degeneration : aging changes and novel therapies / Peter E. Liggett and Alejandro J. Lavaque -- Stargardt disease : from gene discovery to therapy / Rando Allikmets -- X-linked juvenile retinoschisis / Bernhard H. F. Weber and Ulrich Kellner -- Retinal degeneration in Usher syndrome / David S. Williams -- Mouse models of retinitis pigmentosa / Bo Chang ... [et al.] -- The impact of diabetes on neuronal, glial, and vascular cells of the retina : implications for the pathogenesis of diabetic retinopathy / Sylvia B. Smith -- Statins and age-related maculopathy / Gerald McGwin, Jr. and Cynthia Owsley -- The role of drusen in macular degeneration and new methods of quantification / R. Theodore Smith and Umer F. Ahmad -- RPE lipofuscin : formation, properites, and relevance to retinal degeneration / Janet R. Sparrow -- Genetic modifiers that affect phenotypic expression of retinal diseases / Malia M. Edwards ... [et al.] -- X-linked retinal dystrophies and microtubular functions within the retina / Alan F. Wright and Xinhua Shu -- Synaptic remodeling in retinal degeneration / You-Wei Peng and Fulton Wong --On the suppression of photoreceptor cell death in retinitis pigmentosa / Fiona Kernan ... [et al.] -- Cell-based therapies to restrict the progress of photoreceptor degeneration / Raymond D. Lund and Shaomei Wang -- Current status of IPE transplantation and its potential as a cell-based therapy for age-related macular degeneration and retinal dystrophies / Makoto Tamai -- Recent results in retinal transplantation give hope for restoring vision / Robert B. Aramant, Norman D. Radtke, and Magdalene J. Seiler -- Stem cells and retinal transplantation / Joanne Yau ... [et al.] -- Application of encapsulated cell technology for retinal degenerative diseases / Weng Tao and Rong Wen -- Effective treatment for the canine RPE65 null mutation, a hereditary retinal dystrophy comparable to human Leber's congenital amaurosis / Kristina Narfström, Gregory E. Tullis, and Mathias Seeliger -- The use of neuroprotective factors in retinal degenerations / Joyce Tombran-Tink and Colin J. Barnstable -- Carbonic anhydrase inhibitors as a possible therapy for RP17, an autosomal dominant retinitis pigmentosa associated with the R14W mutation, apoptosis, and the unfolded protein response / George Rebello, Jacquie Greenberg, and Raj Ramesar -- Macular Degeneration- an addendum / Joyce Tombran-Tink and Colin J. Barnstable.

Molecular genetics and candidate genes -- Diagnostic, clinical, cytopathological, and physiologic aspects of retinal degeneration -- Animal models of retinal degeneration -- Gene therapy and neuroprotection -- Usher syndrome -- Stem cells, transplantation, and retinal repair -- Induced retinal degenerations.

Part 1. AMD: Basic Mechanisms, Inflammation and Immunity -- Part 2. Neuroprotection, Drugs and Novel Protective Therapies -- Part 3. Gene Therapy -- Part 4. Blood Vessels, Angiogenesis, and Neovascularization -- Part 5. Genotype/Phenotype -- Part 6. New Animal Models of Retinal Degeneration -- Part 7. Analysis of Retinal Degeneration by Imaging and Functional Testing -- Part 8. Mechanisms of Retinal Degeneration -- Part 9. Retinal Development, Physiology, Cell and Molecular Biology.

Sect. IImaging modalities: basic principles and interpretation --Sect. IIMacular diseases --Sect. IIIRetinal vascular diseases --Sect. IVInflammatory and infectious diseases --Sect. VOther retinal diseases --Sect. VITumors --Sect. VIIOptic nerve disorders.

I. Pathogenesis of retinal vascular disease -- 1 Functional anatomy, fine structure and basic pathology -- 2 Retinal vascular development -- 3 Retinal angiogenesis and growth factors -- 4 Hematopoietic stem cells in vascular development and ocular neovascularization -- 5 Inflammation as a stimulus for vascular leakage and proliferation -- 6 The neuronal influence on retinal vascular pathology -- 7 Hypoxia in the pathogenesis of retinal disease -- 8 Blood retinal barrier -- 9 Retinal blood flow -- 10 Genetic approach to retinal vascular disease -- II. General concepts in the diagnosis and treatment of retinal vascular disease -- 11 A practical guide to fluorescein angiography -- 12 Optical coherence tomography in the diagnosis of retinal vascular disease -- 13 General concepts in laser treatment for retinal vascular disease -- 14 The role of photodynamic therapy in retinal vascular disease -- 15 Cryosurgery in retinal vascular disease -- 16 Vitrectomy in retinal vascular disease: surgical principles -- 17 Treatment of rubeotic secondary glaucoma -- 18 Intravitreal injections: guidelines to minimize the risk of endophthalmitis --III. Pathology, clinical course and treatment of retinal vascular diseases -- 19 Grading of diabetic retinopathy -- 20 Retinopathy of prematurity -- 21 Vascular occlusive disease -- 22 Vascular abnormalities -- 23 Vasculopathy after treatment of choroidal melanoma -- 24 Vasculopathies with acute systemic diseases -- 25 Inflammatory vascular disease -- 26 Hypertensive retinopathies -- 27 Sickle cell retinopathy and hemoglobinopathies -- 28 Vascular tumors of the retina.

Anatomy and Pathologic Anatomy of Retinal Vein Occlusions --Pathophysiology of Retinal Vein Occlusions --Genetics of Retinal Vein Occlusions --Classification of Retinal Vein Occlusion --Epidemiology of Retinal Vein Occlusions --Systemic and Ocular Associations of Retinal Vein Occlusions --The Clinical Picture and Natural History of Retinal Vein Occlusions --Ancillary Testing in the Management of Retinal Vein Occlusions --Ischemia and Retinal Vein Occlusions --Posterior Segment Neovascularization in Retinal Vein Occlusion --Anterior Segment Neovascularization in Retinal Vein Occlusion --Macular Edema in Retinal Vein Occlusion --Treatment of Retinal Vein Occlusions --Retinal Vein Occlusions in the Young --Failed and Unadopted Treatments for Retinal Vein Occlusions --Case Studies in Retinal Vein Occlusion.

Anatomical Aspects of the Extra- and Retroperitoneal Space / Ahmed E. Ghazi and Jean V. Joseph -- Essential Instruments in Laparoscopic and Robotic Surgery / Ty T. Higuchi and Matthew T. Gettman -- Upper Tract Retroperitoneal Access Techniques / Ahmed E. Ghazi and Jean V. Joseph -- Laparoscopic and Robotic Adrenalectomy / Edmund Y. Ko, Richard T. Schlinkert and Mitchell R. Humphreys -- Retroperitoneoscopic Simple and Radical Nephrectomy / Guillaume Ploussard, Andras Hoznek, Laurent Salomon, Claude C. Abbou and Alexandre de la Taille -- Laparoscopic and Robotic Partial Nephrectomy / Lori M. Dulabon and Michael D. Stifelman -- Retroperitoneal Robotic Partial Nephrectomy / James R. Porter -- Laparoscopic and Robotic Mid and Distal Ureteral Reconstructive Surgery / Alireza Moinzadeh -- Robot-Assisted Laparoscopic Nephroureterectomy / Sijo J. Parekattil, Hany N. Atalah and Li-Ming Su -- Laparoscopic Pelvic Lymphadenectomy in Prostate Cancer / Evangelos Liatsikos, Minh Do, Panagiotis Kallidonis, Iason Kyriazis and Alan McNeil, et al. -- Laparoscopic Simple Prostatectomy / Xavier Cathelineau, Rafael E. Sanchez-Salas, Eric Barret, Francois Rozet and Marc Galiano, et al. -- Extraperitoneal Laparoscopic Radical Prostatectomy / Sarah P. Psutka and Douglas M. Dahl -- Robot-Assisted Extraperitoneal Laparoscopic Prostatectomy / Thomas T. Hoang, Satya B. Allaparthi and Ingolf A. Tuerk -- Laparoendoscopic Single-Site Retroperitoneal Surgery / Michael A. White and Jihad H. Kaouk -- On the Horizon / Jean V. Joseph and Hitendra R. H. Patel.

Structural studies on HIV reverse transcriptase related to drug discovery / David K. Stammers and Jingshan Ren -- Zidovudine, lamivudine, and abacavir / Monica Carten and Harold Kessler -- Stavudine, didanosine, and zalcitabine / Gail Skowron, Sapna Chowdhry and Michael R. Stevens -- Emtricitabine / Gail Skowron, Jeffrey Bratberg and Rudi Pauwels -- Nucleotide analogs / Craig J. Hoesley -- Resistance to nucleoside and nucleotide reverse transcriptase inhibitors / Nancy Shulman and Mark Winters -- Pharmacokinetics of reverse transcriptase inhibitors / Patrick Hoggard ... [et al.] -- Peripheral neuropathy associated with nucleoside reverse transcriptase inhibitor therapy / Bruce A. Cohen and Russell Bartt -- Mitochondrial dysfunction and nucleoside reverse transcriptase inhibitor therapy: a pathophysiological perspective / William Lewis -- Mitochondrial toxicity and lipodystrophy / Grace McComsey -- Nevirapine / David Asmuth and Richard Pollard -- Efavirenz / Graeme J. Moyle and Brian Conway -- Delavirdine / Brian Conway -- Resistance to non-nucleoside reverse transcriptase inhibitors / F. Ramzi Asfour and Richard Haubrich -- Vertical transmission of HIV and therapeutic interventions / Susan Cu-Uvin, Arlene Bardeguez and Carla Chibwesha -- New reverse transcriptase inhibitors in development / Rudi Pauwels -- Antiretroviral drugs for millions / Allan Ronald, Ellie Katabira and Merle Sande.

Chapter 1. The Physiologic Basis of Homeostasis -- Section. Amplification Systems -- Chapter 2. Nervous System -- Chapter 3. Immune System -- Chapter 4. Endocrine System.

Basic sciences / Mark R. Brinker, Daniel P. O'Connor -- Pediatric orthopaedics / Todd A. Milbrandt, Daniel J. Sucato -- Sports medicine / Joshua A. Baumfeld, Jennifer A. Hart, Mark D. Miller -- Adult reconstruction / Edward J. McPherson -- Disorders of the foot and ankle / Gregory J. Roehrig, MD ... [et al.] -- Hand, upper extremity, and microvascular / Lance M. Brunton, A. Bobby Chhabra -- Spine / William C. Lauerman, Bradley Graw -- Pathology / Frank J. Frassica, Deborah A. Frassica, Edward F. McCarthy -- Rehabilitation: gait, amputations, prosthetics, orthotics / Frank A. Gottschalk -- Trauma / James P. Stannard ... [et al.] -- Anatomy / Franklin D. Shuler -- Principles of practice and statistics / S. Raymond Golish, Mark DeHart.

X-ray production -- X-ray interactions -- Projection radiography I -- Projection radiography II -- Computed tomography -- Image quality -- Radiobiology/patient dosimetry -- Radiation protection -- Nuclear medicine -- Ultrasound -- Magnetic resonance.

The Musculoskeletal System -- Mediators of Rheumatic Pathology -- Immunity -- Genetics -- Rheumatoid Arthritis -- Psoriatic Arthritis -- Systemic Lupus Erythematosus (SLE) -- Arthritis Associated with Calcium-Containing Crystals -- Gout -- Vasculitides -- Systemic Sclerosis and Related Syndromes -- Sjögren's Syndrome -- Behcet's Disease -- Relapsing Polychondritis -- Antiphospholipid Syndrome -- Adult Still's Disease -- Therapeutic Injections for Rheumatic Diseases -- Nonsteroidal Anti-inflammatory Drugs -- Corticosteroids -- Disease-Modifying Antirheumatic Drugs -- Cytotoxic and Immunoregulatory Agents -- Biologic Agents -- Osteoporosis -- Metabolic Bone Disorders -- Paget's Disease of Bone -- Osteonecrosis -- Hypertrophic Osteoarthropathy -- Storage and Deposition Diseases -- Amyloidoses -- The Autoinflammatory Diseases.

v. 1. Infectious diseases.

Ch. 1. DT40 gene disruptions: a how-to for the design and the construction of targeting vectors / Hiroshi Arakawa and Jean-Marie Buerstedde -- Ch. 2. Immunoglobulin gene conversion or hypermutation: That's the question / Jean-Marie Buerstedde and Hiroshi Arakawa -- Ch. 3. Genome resources for the DT40 community / Randolph B Caldwell and Andrzej M. Kierzek -- Ch. 4. Chromosome engineering in DT40 cells and mammalian centromere function / William R.A. Brown ... [et al.] -- Ch. 5. Function of recQ family helicase in genome stability / Masayuki Seki, Shusuke Tada and Takemi Enomoto -- Ch. 6. Genetic analysis of apoptotic execution / Sandrine Ruchaud ... [et al.] -- Ch. 7. The DT40 system as a tool for analyzing kinetochore assembly / Masahiro Okada, Tesuya Hori and Tatsuo Fukagawa -- Ch. 8. Analysing the DNA damage and replication checkpoints in DT40 cells / Michael D Rainey, George Zachos, and David AF Gillespie -- Ch. 9. Using DT40 to study clathrin function / Frank R. Wettey and Antony P. Jackson -- Ch. 10. Genetic analysis OF B cell signaling / Hisaaki Shinohara and Tomohiro Kurosaki --Ch. 11. DT40 mutants: a model to study transcriptional regulation of B cell development and function / Jukka Alinikula, Olli Lassila and Kalle-Pekka Nera -- Ch. 12. Transcription and RNA processing factors play complex roles IN DT40 cells / Stephanie Bush and James L. Manley -- Ch. 13. Participation of histones, histone modifying enzymes and histone chaperones in vertebrate cell functions / Hidehiko Kikuchi ... [et al.] -- Ch. 14. Analysis of gene expression, copy number and palindrome formation with a DT40 enriched cDNA Microarray / Paul E. Neima ... [et al.] -- Ch. 15. Analysis of DNA replication damage bypass and its role in immunoglobulin repertoire development / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 16. The fanconi anemia pathway promotes homologous recombination repair in DT40 cell line / Julian E. Sale, Anna-Laura Ross and Laura J. Simpson -- Ch. 17. Calcium signaling, ion channels and more / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- Ch. 18. Phenotypic analysis of cellular responses to DNA damage / Helfrid Hochegger and Shunichu Takeda -- Ch. 19. ATM, a paradigm for a stress-responsive signal transducer in higher vertebrate cells / Ken-ichi Yamamoto, Masahiko Kobayashi and Hiroko Shimizu --METHOD 1. Stable transfection of DT40 / Julian E. Sale -- METHOD 2. Basic cell culture conditions / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 3. Excision of floxed-DNA sequences by transient induction of Mer-Cre-Mer / Hiroshi Arakawa -- METHOD 4. Immunoglobulin gene conversion and hypermutation assay by FACS / Hiroshi Arakawa -- METHOD 5. Target screening by PCR / Hiroshi Arakawa -- METHOD 6. Mitotic index determination by flow cytometry / David AF Gillespie and Mark Walker -- METHOD 7. Centrifugal elutriation as a means of cell cycle phase separation and synchronization / David AF Gillespie and Catarina Henriques -- METHOD 8. Preparation of genomic DNA for microarray-based comparative genome hybridization / Robert Kimmel, Amalia Icreverzi, Paul Neiman -- METHOD 9. Analysis of cellular Mg2+ in DT40 cells / Anne-Laure Perraud, Carsten Schmitz, Andrew M. Scharenberg -- METHOD 10. Transient transfection of DT40 / Roger Franklin & Julian E. Sale -- METHOD 11. Retroviral transduction of DT40 / Felix Randow & Julian E. Sale -- METHOD 12. Colony survival assay / Laura. J. Simpson & Julian E. Sale -- METHOD 13. Subcloning DT40 by limiting dilution / Jean-Marie Buerstedde --METHOD 14. Subnuclear immunofluorescence / Dávid Szüts & Julian E. Sale -- METHOD 15. Sister chromatid exchange assay / Laura J. Simpson & Julian E. Sale -- METHOD 16. 2D cell cycle analysis / Roger Franklin & Julian E. Sale -- METHOD 17. Purification of tap-tagged proteins by two-step pull down from DT40 cells / Hiroyuki Kitao and Minoru Takata -- METHOD 18. Synchronization of cells / Eiichiro Sonoda -- METHOD 19. Tranfection of DT40 cells / Huseyin Saribasak and Hiroshi Arakawa -- METHOD 20. Luciferase reporter assay / Frank R. Wettey and Antony P. Jackson -- METHOD 21. Indirect immunofluorescence microscopy / Frank R. Wettey and Antony P. Jackson -- METHOD 22. Quantification of receptor-mediated endocytosis / Frank R. Wettey and Antony P. Jackson -- METHOD 23. Measurement of DNA synthesis and strand breaks using alkaline sucrose density gradient centrifugation / Kouichi Yamada and Jun Takezawa -- METHOD 24. Fractionation of nuclear and cytoplasmic proteins from DT40 cell lines / Yan-Dong Wang and Randolph B Caldwell.

The summary of the published clinical guideline on Rheumatoid arthritis. It links to the published guidance and key documents.

Articular disorders -- Diseases of the spine -- Soft-tissue rheumatism and related disorders -- Regional arthrological and musculoskeletal syndromes -- Paraneoplastic syndromes (PNS) in rheumatology -- Algorithms in articular and musculoskeletal disorders: integrated diagnostic screening program: staged diagnostics -- Algorithms in arthrological and musculoskeletal disorders -- General symptoms (BVAS = maximum of 3 out of 63 points) -- Involvement of connective tissue structures -- System-/organ involvement -- (Auto) immunological phenomena and serological diagnostics -- Treatment-induced and associated conditions and diseases -- Integrated diagnostic screening program staged diagnostics -- Algorithms for connective tissue disease and vasculitis.

The Importance of Rheumatic Diseases, The Satisfaction Of Caring For These Patients -- Pain, Disease and Suffering an Integrated Perspective -- The Structure and Function of the Musculoskeletal System Sources of Pain -- Diagnostic Strategy the Main Syndromes in Rheumatology -- The Standard Enquiry in Rheumatology -- The General Clinical Examination -- Regional Syndromes Neck Pain -- Regional Syndromes The Painful Shoulder -- Regional Syndromes The Elbow And Forearm -- Regional Syndromes the Wrist and Hand -- Regional Syndromes Low Back Pain -- Regional Syndromes The Hip -- Regional Syndromes The Knee -- Regional Syndromes the Foot and Ankle -- Generalized Pain Syndrome Fibromyalgia Osteoarthritis -- Inflammatory Arthritides Diagnostic Strategies -- Monoarthritis -- Chronic, Additive, Symmetrical, Peripheral Polyarthritis -- Chronic, Asymmetrical Oligo- Or Polyarthritis -- Chronic Proximal Oligoarthritis -- Arthritis of the Shoulder and Pelvic Girdles Polymyalgia Rheumatica -- Acute Oligo- or Polyarthritis Febrile Arthritis Arthritis with Mucocutaneous Manifestations -- Inflammatory Low Back Pain -- Systemic Syndromes Connective Tissue Diseases Vasculitis Raynaud's Phenomenon -- Osteoporotic Syndrome Osteoporosis -- Bone Syndrome Bone Diseases -- Rheumatic Symptoms in Children and Adolescents -- Treating Rheumatic Diseases, General Principles -- Drugs Commonly Used in Rheumatic Diseases.