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  • Cytometry is one of the most rapidly growing methodologies available for basic cell and molecular biology, cytogenetics, immunology, oncology, environmental sciences and also various fields of clinical medicine. This new edition, split into 2 Parts, is an almost completely new book, with nearly all of the chapters devoted to new topics. Like the previous volumes on cytometry published as part of the Methods in Cell Biology series, it provides a comprehensive description of particular cytometric methods and reviews their applications. Chapters present the theoretical foundations of the described methods, their applicability in experimental laboratory and clinical settings, and describes common traps and pitfalls such as problems with data interpretation, comparison with alternative assays, and choosing the optimal assay. Comprehensive presentation of cytometric methods covering theoretical applications, applicability, potential pitfalls, and comparisions to alternative assays. Discusses many new assays developed since the previous edition * Presents recent developments in cytometric intrumentation/technology.
  • Introduction / Jean-Pierre Bocquet-Appel -- From genes to numbers : effective population sizes in human origins / John Hawks -- Assessment of land surveys in Greece : contributions and limitations / Jean-Nicolas Corvisier -- Estimation of an age distribution with its confidence intervals using an iterative Bayesian procedure and a bootstrap sampling approach / Jean-Pierre Bocquet-Appel and Jean-Noël Bacro -- Model life tables for pre-industrial populations : first application in palaeodemography / Isabelle Séguy ... [et al.] -- The Halley band for paleodemographic mortality analysis / Marc A. Luy and Ursula Wittwer-Backofen -- Modeling Paleolithic predator-prey dynamics and the effects of hunting pressure on prey "choice" / Mary C. Stiner ... [et al.] -- The demography of prehistoric fishing/hunting people : a case study of the Upper Columbia area / Nathan B. Goodale, Ian Kuijt, Anna M. Prentiss -- The paleodemography of central Portugal and the Mesolithic-Neolithic transition / Mary Jackes and Christopher Meiklejohn -- The Libben Site : a hunting, fishing, and gathering village from the Eastern Late Woodlands of North America : analysis and implications for palaeodemography and human origins / Richard S. Meindl, Robert P. Mensforth, C. Owen Lovejoy.
  • Section I. Animal models of PD -- Chapter 1. What have we learned from Drosophila models of Parkinson's disease? / Ming Guo -- Chapter 2. Neurotoxic in vivo models of Parkinson's disease: recent advances / Jason R. Cannon, J. Timothy Greenamyre -- Chapter 3. Behavioral analysis of motor and non-motor symptoms in rodent models of Parkinson's disease / Stephen B. Dunnett, Mariah Lelos -- Chapter 4. Genetic mouse models of Parkinson's disease: The state of the art / Iddo Magen, Marie-Françoise Chesselet -- Chapter 5. Viral vector-mediated overexpression of α-synuclein as a progressive model of Parkinson's disease / Ayse Ulusoy, Mickael Decressac, Deniz Kirik, Anders Björklund -- Chapter 6. Modeling neuroinflammatory pathogenesis of Parkinson's disease / Christopher J. Barnum, Malú G. Tansey -- Chapter 7. The MPTP-lesioned non-human primate models of Parkinson's disease. Past, present, and future / Susan H. Fox, Jonathan M. Brotchie -- Section II. Exploring PD with brain imaging. -- Chapter 8. Abnormal metabolic brain networks in Parkinson's disease: from blackboard to bedside / Chris C. Tang, David Eidelberg -- Chapter 9. Imaging the nigrostriatal system to monitor disease progression and treatment-induced complications / Renju Kuriakose, A. Jon Stoessl -- Chapter 10. Brain imaging after neural transplantation / Marios Politis, Paola Piccini -- Chapter 11. Imaging non-motor aspects of Parkinson's disease / David J. Brooks, Nicola Pavese -- Section III. Frontiers in PD treatment -- Chapter 12. Gene therapy for dopamine replacement / Tomas Björklund, Erik Ahlm Cederfjäll, Deniz Kirik -- Chapter 13. Neurotrophic factor therapy for Parkinson's disease / Suresh Babu Rangasamy, Katherine Soderstrom, Roy A.E. Bakay, Jeffrey H. Kordower -- Chapter 14. Neural grafting in Parkinson's disease: Problems and possibilities / Patrik Brundin, Roger A. Barker, Malin Parmar -- CHAPTER 15. Neural grafting in Parkinson's disease: unraveling the mechanisms underlying graft-induced dyskinesia / Emma L. Lane, Anders Björklund, Stephen B. Dunnett, Christian Winkler -- Chapter 16. Deep brain stimulation: state of the art and novel stimulation targets / Francisco A. Ponce, Andres M. Lozano -- Chapter 17. The challenge of non-motor symptoms in Parkinson's disease / K. Ray Chaudhuri, Per Odin.
  • Section I. Genetic and molecular mechanisms of neurodegeneration in PD -- Chapter 1. Identifying PD-causing genes and genetic susceptibility factors: Current approaches and future prospects / Thomas Gasser -- Chapter 2. The impact of genetic research on our understanding of Parkinson's disease / Ian Martin, Valina L. Dawson, Ted M. Dawson -- Chapter 3. Unravelling the role of defective genes / Mark R. Cookson -- Chapter 4. What causes the death of dopaminergic neurons in Parkinson's disease? / D. James Surmeier, Jaime N. Guzman, Javier Sanchez-Padilla, Joshua A. Goldberg -- Chapter 5. Intracellular signalling pathways in dopamine cell death and axonal degeneration / Robert E. Burke -- Chapter 6. Control of mitochondrial integrity in Parkinson's disease / Cristofol Vives-Bauza, Maja Tocilescu, Rosa L.A. deVries, Dana M. Alessi, Vernice Jackson-Lewis, Serge Przedborski -- Chapter 7. Role of post-translational modifications in modulating the structure, function and toxicity of α-synuclein: Implications for Parkinson's disease pathogenesis and therapies / Abid Oueslati, Margot Fournier, Hilal A. Lashuel -- Section II. Cellular and system-level pathophysiology of the basal ganglia in PD -- Chapter 8. The role of dopamine in modulating the structure and function of striatal circuits / D. James Surmeier, Weixing Shen, Michelle Day, Tracy Gertler, Savio Chan, Xianyong Tian, Joshua L. Plotkin -- Chapter 9. Assemblies of glutamate receptor subunits with post-synaptic density proteins and their alterations in Parkinson's disease / Fabrizio Gardoni, Veronica Ghiglieri, Monica di Luca, Paolo Calabresi -- Chapter 10. Pathophysiological roles for purines: Adenosine, caffeine and urate / Micaela Morelli, Anna R. Carta, Anil Kachroo, Michael A. Schwarzschild -- Chapter 11. Maladaptive striatal plasticity in l-DOPA-induced dyskinesia / M. Angela Cenci, Christine Konradi -- Chapter 12. Effects of GPi and STN inactivation on physiological, motor, cognitive and motivational processes in animal models of Parkinson's disease / Christelle Baunez, Paolo Gubellini -- Chapter 13. Computational physiology of the basal ganglia in Parkinson's disease / Michal Rivlin-Etzion, Shlomo Elias, Gali Heimer, Hagai Bergman -- Chapter 14. Neurocomputational models of motor and cognitive deficits in Parkinson's disease / Thomas V. Wiecki, Michael J. Frank.
  • Recent Advances in Prolactin Research summarizes the current knowledge of prolactin (PRL), PRL receptor, PRL-dependent signaling pathways, the role of PRL in oncogenesis and PRL crosstalk with other oncogenic factors. The chapters are written by experts in these fields and focus on identifying and reviewing timely experimental findings that provide new insights into the expanding role of PRL in the pathophysiology associated with a variety of human conditions. Prolactin is a peptide hormone that is best known for its role in lactation. Prolactin also has an influence on hematopoiesis and angiogenesis, and is involved in the regulation of blood clotting through several pathways. Although PRL was discovered more than 80 years ago, the understanding of PRL signaling and its relationship to various pathologies is still very incomplete. PRL is not only a pituitary hormone with an important role in reproduction, but PRL also acts as a cytokine, modulating a wide variety of physiological processes. For example, data gathered during the last decade have demonstrated that locally produced PRL acts as the autocrine/paracrine factor and plays a contributory role during breast oncogenesis. In fact, the scientific and clinical communities have suggested that the manipulation of the PRL axis may lead to the successful treatment of breast cancer. However, recent work has demonstrated that the role of the PRL axis is much more complex than first envisaged.
  • Amoeba provide insight into the origin of virulence in pathogenic fungi / Arturo Casadevall -- Of model hosts and man: using Caenorhabditis elegans, Drosophila melanogaster and Galleria mellonella as model hosts for infectious disease research / Justin Glavis-Bloom, Maged Muhammed, and Eleftherios Mylonakis -- Caenorhabditis elegans as an alternative model to study senescence of host defense and the prevention by immunonutrition / Tomomi Komura ... [et al.] -- Bacterial effectors: learning on the fly / Laurent Boyer ... [et al.] -- Drosophilia asthma model: what the fly tells us about inflammatory diseases of the lung / Thomas Roeder ... [et al.] -- Elucidating the in vivo targets of Photorhabdus toxins in real-time using Drosophilia embryos / Isabella Vlisidou, Nicholas Waterfield, and Will Wood -- Ecological niche modeling as a tool for understanding distributions and interactions of vectors, hosts, and etiologic agents of Chagas disease / Jane Costa and A. Townsend Peterson -- Where simplicity meets complexity: Hydra, a model for host-microbe interactions / René Augustin ... [et al.] -- Tick as a model for the study of primitive complement system / Petr Kopacek, Ondrej Hajdusek, and Veronika Buresova -- Model hosts for the study of oral candidiasis / Juliana Campos Junqueira -- Creating a pro-survival and anti-inflammatory phenotype by modulation of acetylation in models of hemorrhagic and septic shock / Yongqing Li and Hasan B. Alam.
  • Receptor databases and computational websites for ligand binding -- Identification of orphan G protein-coupled receptor ligands using FLIPR assays -- Quantitative analysis of orphan G protein-coupled receptor mRNAs by TaqMan real-time PCR: G2A and GPR4 lysophospholipid receptor expression in leukocytes and in a rat myocardial infarction-heart failure model -- mRNA: detection by in situ and northern hybridization -- Radioligand-binding and molecular-imaging techniques for the quantitative analysis of established and emerging orphan receptor systems -- Measurement of radioligand binding by scintillation proximity assay -- Autoradiography of enzymes, second messenger systems, and ion channels -- Immunocytochemical localization of receptors using light and confocal microscopy with application to the phenotypic characterization of knock-out mice -- Live cell imaging of G protein-coupled receptors --Imaging and characterization of radioligands for positron emission tomography using quantitative phosphor imaging autoradiography -- Dynamic in vivo imaging of receptors in small animals using positron emission tomography.
  • This new volume of Methods in Cell Biology looks at receptor-receptor interactions, with sections on allosteric and effector interactions, crystallization and modeling, measuring receptor-receptor interactions and oligomerization in individual classes. With cutting-edge material, this comprehensive collection is intended to guide researchers of receptor-receptor interactions for years to come.
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    v. 1. General principles and procedures.
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  • Part I. Redefinition -- 1. Selenocysteine Biosynthesis, Selenoproteins, and Selenoproteomes / Vadim N. Gladyshev and Dolph L. Hatfield -- 2. Reprogramming the Ribosome for Selenoprotein Expression: RNA Elements and Protein Factors / Marla J. Berry and Michael T. Howard -- 3. Translation of UAG as Pyrrolysine / Joseph A. Krzycki -- 4. Specification of Standard Amino Acids by Stop Codons / Olivier Namy and Jean-Pierre Rousset -- 5. Ribosome “Skipping”: “Stop-Carry On” or “StopGo” Translation / Jeremy D. Brown and Martin D. Ryan -- 6. Recoding Therapies for Genetic Diseases / Kim M. Keeling and David M. Bedwell -- Part II. Frameshifting - Redirection of Linear Readout -- 7. Pseudoknot-Dependent Programmed -1 Ribosomal Frameshifting: Structures, Mechanisms and Models / Ian Brierley, Robert J.C. Gilbert, and Simon Pennell -- 8. Programmed -1 Ribosomal Frameshift in the Human Immunodeficiency Virus of Type 1 / Léa Brakier-Gingras and Dominic Dulude -- 9. Ribosomal Frameshifting in Decoding Plant Viral RNAs / W. Allen Miller and David P. Giedroc -- 10. Programmed Frameshifting in Budding Yeast / Philip J. Farabaugh -- 11. Recoding in Bacteriophages / Roger W. Hendrix -- 12. Programmed Ribosomal -1 Frameshifting as a Tradition: The Bacterial Transposable Elements of the IS3 Family / Olivier Fayet and Marie-Françoise Prère -- 13. Autoregulatory Frameshifting in Antizyme Gene Expression Governs Polyamine Levels from Yeast to Mammals / Ivaylo P. Ivanov and Senya Matsufuji -- 14. Sequences Promoting Recoding Are Singular Genomic Elements / Pavel V. Baranov and Olga Gurvich -- 15. Mutants That Affect Recoding / Jonathan D. Dinman and Michael O'Connor -- 16. The E Site and Its Importance for Improving Accuracy and Preventing Frameshifts / Markus Pech, Oliver Vesper, Hiroshi Yamamoto, Daniel N. Wilson, and Knud H. Nierhaus -- Part III. Discontiguity -- 17. Translational Bypassing - Peptidyl-tRNA Re-pairing at Non-overlapping Sites / Norma M. Wills -- 18. trans-Translation / Kenneth C. Keiler and Dennis M. Lee -- Part IV. Transcription Slippage -- 19. Transcript Slippage and Recoding / Michael Anikin, Vadim Molodtsov, Dmitry Temiakov, and William T. McAllister -- Part V. Appendix -- 20. Computational Resources for Studying Recoding / Andrew E. Firth, Michaël Bekaert, and Pavel V. Baranov.
  • pt. B ScienceDirect
  • This book is intended to help practitioners understand the causes and effects of disordered breathing and to provide strategies and protocols to help restore normal function. Fully updated throughout, this volume has been completely revised to guide the practitioner in the recognition of breathing pattern disorders and presents the latest research findings relating to the condition including a range of completely new techniques - many from an international perspective - to help restore and maintain normal functionality. Video clips on an associated website presents practical examples of the breathing techniques discussed in the book. Carefully prepared by a global team of renowned experts under the guidance of Leon Chaitow Focuses on practical, validated, and clinically relevant information Abundant use of pull-out boxes, line artwork, photographs and tables facilitates ease of understanding Contains clinical cases to ensure full comprehension of the topics explored Suitable for physiotherapists, manual therapists, physical therapists, osteopaths, osteopathic physicians and chiropractors, massage therapists, Pilates and yoga teachers & therapists, Tai chi and Feldenkrais practitioners, athletic coaches and voice-coaches.
  • From Neanderthal to nanobiotech : from plant potions to pharming with plant factories / Christophe Sourrouille ... [et al.] -- Cowpea mosaic virus-based systems for the expression of antigens and antibodies in plants / Frank Sainsbury, Li Liu, and George P. Lomonossoff -- Transient expression of antibodies in plants using syringe agroinfiltration / Marc-André D'Aoust ... [et al.] -- Rapid system for evaluating bioproduction capacity of complex pharmaceutical proteins in plants / Giuliana Medrano ... [et al.] -- Production and localization of recombinant pharmaceuticals in transgenic seeds / Thomas Rademacher, Elsa Arcalis, and Eva Stoger -- Production of antibody fragments in Arabidopsis seeds / Bart Van Droogenbroeck, Kirsten De Wilde, and Ann Depicker -- Production of plantibodies in Nicotiana plants / Marta Ayala ... [et al.] -- Physcomitrella patens : a non-vascular plant for recombinant protein production / David Liénard and Fabien Nogué -- Production of recombinant proteins in suspension-cultured plant cells / Carole Plasson ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals : protocols for expression, purification, or oral delivery and functional evaluation / N. Dolendro Singh, Yi Ding, and Henry Daniell -- Protein body induction : a new tool to produce and recover recombinant proteins in plants / Margarita Torrent, Imma Llop-Tous, and M. Dolors Ludevid -- A case study for plant-made pharmaceuticals comparing different plant expression and production systems / Guy Vancanneyt ... [et al.] -- Glycosylation of antibody therapeutics : optimisation for purpose / Roy Jefferis -- N-glycosylation of plant recombinant pharmaceuticals / Muriel Bardor ... [et al.] -- Companion protease inhibitors to protect recombinant proteins in transgenic plant extracts / Meriem Benchabane ... [et al.] -- Strategies for improving vaccine antigens expression in transgenic plants : fusion to carrier sequences / Jose M. Escribano and Daniel M. Perez-Filgueira -- Immunomodulation of plant function by in vitro selected single-chain Fv intrabodies / Manfred Gahrtz and Udo Conrad -- On-chip detection of low-molecular-weight recombinant proteins in plant crude extracts by SELDI-TOF MS / Amine M. Badri ... [et al.] -- Assessing the risk of undesirable immunogenicity/allergenicity of plant-derived therapeutic proteins / Paul D. Chamberlain -- Biosafety, risk assessment, and regulation of plant-made pharmaceuticals / Penelope A.C. Sparrow and Richard M. Twyman.
  • "Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome, reshuffling the homologous chromosomes by their centromeres, and recombining chromosome arms by crossing-over. In animals, including humans, all this happens during the germ cell formation of eggs and sperm. Due to the reign of meiosis, no child is a true genetic copy of either parent. Questions still open primarily concern the placement of and mutual coordination between neighboring crossover events. The current book addresses these processes and mechanisms in multicellular eukaryotes, such as Drosophila, Anibidopsis, mice and humans. The pioneering model systems of yeasts, as well as evolutionary aspects, will be addressed in a forthcoming volume."--Jacket.
  • Once per life cycle, mitotic nuclear divisions are replaced by meiosis I and II - reducing chromosome number from the diploid level to a haploid genome and recombining chromosome arms by crossing-over. In animals, all this happens during formation of eggs and sperm - in yeasts before spore formation. The mechanisms of reciprocal exchange at crossover/chiasma sites are central to mainstream meiosis. To initiate the meiotic exchange of DNA, surgical cuts are made as a form of calculated damage that subsequently is repaired by homologous recombination. These key events are accompanied by ancillar.
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    Classical mendelian genetics -- Genetics and the phage biologists -- The physicist becomes a phage biologist -- To Paris and back -- Teaching and research at Purdue -- Entering the rII region -- Crossing into the fine structure -- Is gene a dirty word? -- The survival of the "gene".
  • Actin filament dynamics using microfluidics -- Bacterial actin-like proteins: purification and characterization of self-assembly properties -- Quantitative analysis of microtubule self-assembly kinetics and tip structure -- Biochemical reconstitution of the WAVE regulatory complex -- Rotational movement of formins evaluated by using single-molecule fluorescence polarization -- Single-molecule studies of actin assembly and disassembly factors -- Assaying microtubule nucleation of the [gamma]-Tubulin ring complex -- Reconstituting dynamic microtubule polymerization regulation by TOG domain proteins -- Generation of differentially modified microtubules using In Vitro enzymatic approaches -- Engineering defined motor ensembles with DNA origami -- Construction and analyses of elastically coupled multiple-motor systems -- Reconstitution of cortical dynein function -- Reconstitution of microtubule-dependent organnelle transport -- Reconstituting the motility of isolated intracellular cargoes -- Reconstitution of contractile actomyosin arrays -- Directed actin assembly and motility -- In Vitro reconstitution of dynamic microtubules interacting with actin filament networks -- Measuring kinetochore-microtubule interaction In Vitro -- Micropattern-guided assembly of overlapping pairs of dynamic microtubules -- WAVE regulatory complex activation -- Dissecting principles governing actin assembly using yeast extracts -- Xenopus egg ctyoplasm with intact actin -- Glycogen-supplemented mitotic cytosol for analyzing xenopus egg microtubule organization -- Spindle assembly on immmobilized chromatin micropatterns.
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    "The two world wars played an important role in the evolution of plastic and maxillofacial surgery in the first half of the 20th century. This book is about four of the key figures involved. Sir Harold Gillies and Sir Archibald McIndoe were born in Dunedin; McIndoe and Rainsford Mowlem studied medicine at the University of Otago Medical School, and Henry Pickerill was foundation Dean of the University of Otago Dental School. The author describes how these surgeons revolutionised plastic surgery and the treatment of facial trauma, working on soldiers, fighter pilots and civilians disfigured by bombs, shrapnel and burns. Eventually Gillies et al. were supported by a vast surgical enterprise that included surgeons, dentists, anaesthetists, artists and photographers, nurses and orderlies. The text is fully illustrated with photos, drawings and case notes by the surgeons and war artists at military hospitals at Boulogne-sur-Mer, Aldershot and Sidcup in the First World War, and civilian hospitals at East Grinstead, Basingstoke and Hill End in the Second. The book includes a DVD of Rainsford Mowlem performing a variety of plastic operations in 1945. This book is a must for anyone interested in the history of medicine and the treatment of casualties in the two world wars"--From publisher.
  • section A. Introduction and general context -- section B. Reconstructing and using the tree of life -- section C. Taxonomy and systematics of species rich groups (case studies).
  • Surgical anatomy -- Biomechanical remarks -- Special radiology -- Surgical approaches -- Basic principles of reconstruction techniques -- Specific reconstruction techniques of upper cervical spine and craniovertebral junction -- Virtual and real time navigational techniques -- Traumatic atlantooccipital dislocation (AOD) -- Occipital condyle fractures -- Atlas fractures -- Odontoid process fractures -- Fractures of the ring of axis (hangman type fractures) -- Miscellaneous C2 fractures -- Multiple fractures of axis and atlas-axis fracture combinations -- Acute traumatic atlantoasial dislocation (AAD) in adults -- Posttraumatic deformity -- Non-specific inflammation -- Rheumatoid arthritis -- Tumors -- Congenital and developmental abnormalities -- Degenerative disorders -- Surgical failures.
  • World-renowned surgeon Dr. Mark S. Myerson returns with a Second Edition of Reconstructive Foot and Ankle Surgery. This surgical technique reference delivers step-by-step guidance on the essential elements of complex foot and ankle surgery and is packed with full-color illustrations, pearls, and pitfalls. New chapters focus on the complications management of complications, aimed to help you select the right procedure for challenging conditions to ensure optimal outcomes. Learn from one of the very best - world-renowned surgeon Dr. Mark S. Myerson shares his innovative approaches to the reconstructive surgical techniques and complications management most frequently seen in practice. Quickly reference essential topics with a templated, focused format emphasizing procedures rather than basic science.
  • Reconstructive Surgery of the Rectum, Anus and Perineum provides the reader with a didactic discussion of complex problems which require re-operative surgery; including details of preoperative investigation, postoperative follow-up and a detailed operative approach. This comprehensive and detailed text uses a formulated algorithm approach to these complicated cases using operative photographs and composite explanatory line drawings which complement 'how-to' guides in describing the operative technical tips and pitfalls from experienced commentators. Reconstructive Surgery of the Rectum, Anus and Perineum, is written by leading world experts in the field of colorectal surgery and is a valuable and timely resource for colorectal surgeons and colorectal trainees alike. In addition, general surgeons will be interested in the specialist nature of dealing with difficult colorectal complications dealt with in this unique textbook.
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  • This book gives an updated and detailed overview of diagnostic and therapeutic strategies for rectal cancer. Rectal cancer has become an increasing and serious disease in western countries, mainly linked to lifestyle and bad alimentation habits. This specific cancer is not only a threat to the lifespan of patients, but also has a heavy impact on quality of life, due to its implications in the fecal, urinary and sexual functions. Recent guidelines of prevention and early diagnosis, as well as current and future diagnostic and staging work-up, are here presented in a clear and convincing way, linking each topic to the therapeutic options arising from the staging and including a chapter on the molecular evaluation of the tumor. To complete the multifaceted approach to this particular pathology, a large part is devoted to the in-hospital care of rectal cancer patients, beginning from the fast-track procedures and the enhanced recovery systems, up to the in-depth description of the available of surgical techniques, including salvage situations, accidents, complications, and their treatment. A final chapter will be dedicated to the follow-up policy and its advantages.
  • This book on the morphology of corneal surface changes in recurrent erosion syndrome and epithelial edema presents high-magnification images captured in vivo by the method of non-contact photomicrography. Part I of the book, on recurrent erosion syndrome, displays images covering a broad spectrum of epithelial changes, including manifestations of the ongoing underlying pathological process and epithelial activity aimed at elimination of abnormal elements and repair. The dynamics of the interplay between these opposing forces are captured in sequential photographs that are invaluable for interpretation. Case reports illustrate typical features of the disease and document the variability of symptoms and findings in the same individual over time. Also included are images of the appearance and dynamics of corneal stromal infiltrates, a rare but potentially sight-threatening complication. Part II of the book demonstrates typical features of corneal epithelial edema and also covers the occasional contemporaneous occurrence, and dynamics, of various phenomena indistinguishable from those commonly seen in recurrent erosion syndrome. Again, informative case reports are included. The in vivo images displayed in this book, obtained at a higher magnification than that used in standard photography, reveal additional details of epithelial changes. The presented morphology will facilitate understanding of clinical appearances and assist in differential diagnosis.
  • Ch. 1. Introduction -- ch. 2. Determinants of red blood cell aggregation -- ch. 3. Mechanism of red blood cell aggregation -- ch. 4. Measurement of red blood cell aggregation -- ch. 5. Effect of red blood cell aggregation on in Vitro blood rheology -- ch. 6. Effect of red blood cell aggregation on tube flow -- ch. 7. In Vivo hemodynamics and red blood cell aggregation -- ch. 8. Alterations in red blood cell aggregation -- ch. 9. Comparative aspects of red blood cell aggregation.
  • Red book online
    Silverchair
    Red Book Online is the online home of the Report of the AAP Committee on Infectious Diseases. Offering instant Web-based access, Includes complete text of the Red Book, plus the complete visual library of images from the Visual Red Book on CD-ROM and more.
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    A shocking tour through a macabre global underworld where organs, bones, and live people are bought and sold on the red market. Investigative journalist Scott Carney has spent five years tracing the lucrative and deeply secretive trade in human bodies and body parts. The Red Market reveals the rise, fall, and resurgence of this multibillion-dollar underground trade through history, from early medical study and modern universities to poverty-ravaged Eurasian villages and high-tech Western labs; from body snatchers and surrogate mothers to skeleton dealers and the poor who sell body parts to survive. While local and international law enforcement have cracked down on the market, advances in science have increased the demand for human tissue--ligaments, kidneys, even rented space in women's wombs--leaving little room to consider the ethical dilemmas inherent in the flesh-and-blood trade--From publisher description.
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    What are disabilities? -- Why focus on children with disabilities? -- What are the challenges in delivering health care to children with disabilities? -- Inclusion -- Contribution -- Health -- Focusing health care on function -- Comprehensive integrated care plans -- Family- and person-centered care -- Care coordination / with Alexis Hansen -- Changing professional education -- Research / with Nathan J. Blum -- Public policy.
  • Reactive oxygen species in normal and tumor stem cells / Daohong Zhou, Lijian Shao and Douglas R. Spitz -- Emerging regulatory paradigms in glutathione metabolism / Yilin Liu, Annastasia S. Hyde, Melanie A. Simpson, and Joseph J. Barycki -- Gamma-glutamyl transpeptidase: redox regulation and drug resistance / Marie H. Hanigan -- Pleiotropic functions of glutathione S-transferase P / Jie Zhang, Christina Grek, Zhi-Wei Ye, Yefim Manevich, Kenneth D. Tew and Danyelle M. Townsend -- A comparison of reversible versus irreversible protein glutathionylation / Danyelle M. Townsend, Volodymyr I. Lushchak and Arthur J. L. Cooper -- Glutathione transferases in the bioactivation of azathioprine / Olof Modén and Bengt Mannervik -- Thioredoxin and hematological malignancies / Ningfei An and Yubin Kang -- Role of the Keap1-Nrf2 pathway in cancer / Hanna M Leinonen, Emilia Kansanen, Petri Pölönen, Merja Heinäniemi and Anna-Liisa Levonen.
  • Redox cell biology and genetics. Part A-B pt. A-B, 2002.
    ScienceDirect
    pt. B ScienceDirect
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  • The role of redox in signal transduction / John T. Hancock -- The measurement of nitric oxide and its metabolites in biological samples by ozone-based chemiluminescence / Andrew G. Pinder ... [et al.] -- Detection and measurement of reactive oxygen intermediates in mitocondria and cells / Matthew Whiteman ... [et al.] -- Redox-sensitive green fluorescent protein : probes for dynamic intracellular redox responses : a review / Mark B. Cannon and S. James Remington -- Measuring redox changes in vivo in leaves : prospects and technical challenges / Philip M. Mullineaux and Tracy Lawson -- Imaging of intracellular hydrogen peroxide production with hyper upon stimulation of hela cells with Egf / Kseniya N. Markvicheva ... [et al.] -- Tools to investigate ROS sensitive signalling proteins / Radhika Desikan ... [et al.] -- Methods for preparing crystals of reversibly oxidized proteins : crystallization of protein tyrosine phophatase 1b as an example / Annette Salmeen and David Barford -- Methods for the study of redox-mediated changes in p53 structure and function / Kristine Mann -- Redox regulation and trapping sulphenic acid in the peroxide sensitive human mitochondrial branched chain aminotransferase / Susan M. Hutson ... [et al.] -- Detection of carbonylated proteins in 2-D SDS page separations / Rukhsana Sultana ... [et al.] -- Analysis of global and specific changes in the disulfide proteome using redox 2D-PAGE / Robert C. Cumming -- Protein-thiol oxidation from single proteins to proteome-wide analyses / Natacha Le Moan, Frédérique Tacnet, and Michel B. Toledano -- Analysis of redox relationships in the plant cell cycle : determinations of ascorbate, glutathione, and poly (ADPribose) polymerase (PARP) in plant cell cultures / Christine H. Foyer ... [et al.] -- Generation and detection of S-nitrosothiols / Christian Lindermayr, Simone Sell, and Jörg Durner.
  • Reduced port laparoscopic surgery is a fast-developing topic for the laparoscopic surgeon, with the emergence of a number of new techniques as well as new instruments. Edited by surgeons who have pioneered the single-incision approach, this volume provides extensive information for the beginning surgeon, examining different operation techniques and covering the advantages and pitfalls of reduced port laparoscopic surgery. In addition, the text provides the foundation for new ideas to further develop skills for the advanced laparoscopic surgeon.
  • This book describes the techniques, strategies, and drugs that have been demonstrated by well-documented randomized trials to influence survival in the perioperative setting. It takes into consideration all types of adult surgery and will be relevant to the evaluation of any patient undergoing an operative procedure. Each chapter focuses on a specific procedure, device, or drug. The scope is accordingly wide, with coverage of topics as diverse as chlorhexidine oral rinse, clonidine therapy, insulin infusion, intra-aortic balloon pump support, leukodepletion, neuraxial anesthesia, and noninvasive respiratory support, to name but a few. In addition, the risks and benefits of using a web-based consensus process (as in this book) to identify effective means of reducing perioperative mortality are discussed. The clear text is supported by "how to do" sections and "key points" boxes that provide easily accessible practical information. Written by acknowledged international experts, Reducing Mortality in the Perioperative Period will be of interest for a wide variety of specialists, including surgeons, cardiologists, anesthesiologists, and intensivists.
  • Introduction: challenges in reducing disparities in reproductive and perinatal outcomes through evidence-based public health -- Methodological approach to assessing the evidence -- Evidence-based public health: origins, assumptions, and cautions -- Access to family planning and induced abortion -- Preconceptional health promotion -- Infertility status and infertility treatment: racial and ethnic disparities -- Public health interventions for perinatal HIV and STI screening in pregnancy -- What is the role of prenatal care in reducing racial and ethnic disparities in pregnancy outcomes? -- Current approaches to reducing premature births and implications for disparity elimination -- Prenatal case management of pregnant women: what is the evidence for its contribution to a reduction of disparities in perinatal outcomes? -- Behavioral treatment methods for pregnant smokers: the evidence base for prenatal care programs and professional practice -- Substance abuse in pregnancy: the impact of screening and treatment on improving perinatal outcomes and reducing racial and ethnic disparities -- The evidence for perinatal depression screening and treatment -- Supplemental nutrition programs during pregnancy and the early postnatal period -- Group prenatal care and doula care for pregnant women -- Contemporary childbirth in the United States: interventions and disparities -- Regionalized perinatal care: an evidence-based intervention in development.
  • 1. The Challenges of Multiple Pregnancies -- 2. Prognosis of Risks for Offspring of Fertility Treatment -- 3. Ovarian Hyperstimulation Syndrome -- 4. Thromboembolism Associated with Fertility Treatment -- 5. Emotional and Psychosocial Risk Associated with Fertility Treatment -- 6. Regulatory and Legal Risks for Patients.
  • Complications of Spinal Cord Stimulation -- Complications of Peripheral Nerve Stimulation : Open Technique, Percutaneous Technique, and Peripheral Nerve Field Stimulation -- Complications of Cranial Nerve Stimulation -- Avoidance, Recognition, and Treatment of Complications in Cranial Neuromodulation for Pain -- Complications of Intrathecal Drug Delivery Systems -- Complications of Therapeutic Minimally Invasive Intradiscal Procedures -- Complications Related to Radiofrequency Procedures for the Treatment of Chronic Pain -- Complications of Lumbar Spine Fusion Surgery -- Complications of Nucleus Replacement and Motion-Sparing Technologies -- Complications of Spinal Injections and Surgery for Disc Herniation -- Radiation Safety and Complications of Fluoroscopy, Ultrasonography, and Computed Tomography -- Complications Associated with Head and Neck Blocks, Upper Extremity Blocks, Lower Extremity Blocks, and Differential Diagnostic Blocks -- Complications of Epidural Injections -- Complications of Facet Joint Injections and Medial Branch Blocks -- Complications of Radiofrequency Rhizotomy for Facet Syndrome -- Complications of Sacroiliac Joint Injection and Lateral Branch Blocks, Including Water-Cooled Rhizotomy -- Complications of Percutaneous Vertebral Augmentation : Vertebroplasty and Kyphoplasty -- Complications of Intraarticular Joint Injections and Musculoskeletal Injections.
  • pt. 1. Dietary salt, health and the consumer -- pt. 2. Strategies for salt reduction in food products -- pt. 3. Reducing salt in particular foods.
  • Toxicity testing is used to assess the safety or hazards presented by substances such as industrial chemicals, consumer products, and pharmaceuticals. At present, many methods involve laboratory animals. Alternative procedures, some involving human cell-based technologies, are now being developed which reduce, refine, or replace animal usage and minimize the pain and distress caused. These new tests must protect public health and the environment at least as well as currently accepted methods. This book describes the ever-expanding "toolbox" of methods available to assess toxicity. Such techniques often result from our growing understanding of the biochemical and cellular pathways that mediate toxicity mechanisms. This permits evaluations of information generated from several sources to generate a "weight of evidence". By combining in silico, in vitro, and ex vivo methods with technologies that rely on biochemical- and cell-based in vitro assays, toxicologists are developing mechanistically based alternatives to live animal experimentation. This text also explores the complexities associated with adequate validation, and the assessment of test reliability and relevance. It provides an essential reference source for postgraduates, academics and industrialists working in this rapidly changing area.
  • Print Material
  • Part 1. Confocal Reflectance Microscopy - the Essentials -- The Confocal Story -- How Reflectance Confocal Microscopy Works -- A Hands-on Guide to Confocal Imaging -- Part 2. Normal Skin -- Epidermis, Dermis and Epidermal Appendages -- Acral Volar Skin, Facial Skin and Mucous Membrane -- Part 3. Melanocytic lesions -- Semeiology and Pattern Analysis in Melanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Part 4. Melanocytic lesions: Nevi -- Common Nevi -- Atypical/Dysplastic Nevi -- Spitz Nevi -- In Vivo Confocal Reflectance Microscopy of Congenital Melanocytic Nevi -- The Many Faces of Nevi: Blue, "Black" and Recurrent Nevi -- Part 5. Melanocytic lesions: Melanoma -- Superficial Spreading Melanoma -- Melanoma Progression -- Nodular Melanoma -- Lentigo Maligna -- Amelanotic Melanoma -- Part 6. Non-melanocytic Skin Lesions -- Semiology and Pattern Analysis in Nonmelanocytic Lesions -- Dermoscopic and Histopathologic Correlations -- Solar Lentigo, Seborrheic Keratosis and Lichen Planus-Like Keratosis -- Basal Cell Carcinoma -- Actinic Keratosis -- Squamous Cell Carcinoma -- Cutaneous Lymphoma -- Potpourri of Nonmelanocytic Skin Lesions -- Part 7. Inflammatory Skin Diseases -- The Semiology and Patterns of Inflammatory Skin Conditions -- Hyperkeratotic Dermatitis -- Spongiotic Dermatitis -- Interface Dermatitis -- Pigmentary Skin Disorders -- Part 8. Monitoring of Skin Lesions and Therapy Control -- Follow-up of Nevi -- Monitoring of Nonsurgical Treatment of Skin Tumors -- Confocal Mosaicing Microscopy in Skin Excisions: Feasibility of Cancer Margin Screening at the Bedside to Guide Mohs Surgery -- Reflectance Confocal Microscopy Applications in Cosmetology -- Part 9. Future Aspects -- Tele-Reflectance Confocal Microscopy -- Automated Diagnosis and Reflectance Confocal Microscopy -- Experimental Applications and Future Directions -- Part 10. Glossary -- Reflectance Confocal Microscopy Imaging: A Glossary of Terminology.
  • Ch. 1 Crystalline lens as a target for refractive surgery -- Ch. 2 Refractive lens exchange as a refractive surgery modality -- Ch. 3 Biometry for refractive lens surgery -- Ch. 4 Intraocular lens power calculations: correction of defocus -- Ch. 5 IOL calculations following keratorefractive surgery -- Ch. 6 Correction of keratometric astigmatism: incisional surgery -- Ch. 7 STAAR toric IOL -- Ch. 8 Correction of keratometric astigmatism: AcrySof toric IOL -- Ch. 9 Wavefront technology of spherical aberration -- Ch. 10 The Eyeonics Crystalens -- Ch. 11 Presbyopia - cataract surgery with implantation of the accommodative posterior chamber lens ICU -- Ch. 12 Synchrony IOL -- Ch. 13 Sarfarazi elliptical accommodative intraocular lens -- Ch. 14 AcrySof ReStor pseudo-accommodative IOL -- Ch. 15 The Tecnis Multifocal IOL -- 16 Blue-light-filtering intraocular lenses -- Ch. 17 The light-adjustable lens -- Ch. 18 Injectable polymer -- Ch. 19 The vision membrane -- Ch. 20 Bimanual ultrasound phacoemulsification -- Ch. 21 Low ultrasound microincision cataract surgery -- Ch. 22 The Infiniti Vision System -- Ch. 23 The Millenium -- Ch. 24 The Staar Sonic Wave -- Ch. 25 AMO Sovereign with WhiteStar Technology -- Ch. 26 Refractive lens exchange in high myopia: weighing the risks -- Ch. 27 Conclusion: the future of refractive lens surgery -- Subject index. DVD: 1. Transition to bimanual phaco -- 2. Bimanual vertical chop technique #1 -- 3. Bimanual vertical chop technique #2 -- 4. VST torn capsule -- 5. Bimanual post PKP post RK -- 6. Spinoffs of bimanual technology.
  • Refractive surgery 2008
    ClinicalKey
    1. Bausch & Lomb 217z100 excimer laser platform / Sheraz M. Daya and Marcela Espinosa-Lagana -- 2. Custom LASIK and PRK with the Visx Star Laser / Michael J. Taravella, Richard S. Davidson and Scott A. Thomas -- 3. The LadarVision system / Ronald R. Krueger -- 4. WaveLight Allegretto / Simon Holland and C. David Lin -- 5. Nidek Navex / Mihai Pop and Harkaran S. Bains -- Schwind ESIRIS excimer laser / Diego de Ortueta, Thomas Magnago and Jens Flügge -- 7. Optimized and wavefront-guided corneal refractive surgery using the Carl Zeiss Meditec platform: CRS-Master and MEL 80 excimer laser / Daniel Z. Reinstein et al. -- 8. Multifocal cornea / Gustavo E. Tamayo -- 9. Katana LaserSoft: a solid-state laser for refractive surgery / Matteo Piovella, Fabrizio I. Camesasca and Barbara Kusa -- 10. CustomVis Pulzar Z1 / Tarak Pujara -- 11. Refractive lens exchange / Mark Packer, I. Howard Fine, Richard S. Hoffman and H. Burkhard Dick -- 12. Surgical reversal of presbyopia / Gene W. Zdenek and Jack C. Griffis.
  • "Physicians receive very little training in refugee health. Refugee Health Care is a practical guide providing concise information for busy practitioners. This concise textbook reviews common conditions seen in refugees and some of the recommendations in the book apply to all immigrants. It will be a valuable resource for primary care physicians, psychiatrists, pediatricians, women's health providers and any health care practitioner who treats refugees."--Publisher's website.
  • Inducing embryonic stem cells to become cardiomyocytes / Alexander M. Becker, Michael Rubart, and Loren J. Field -- Regenerating function in vivo with myocytes derived from embryonic stem cells / Priya R. Baraniak and Todd C. McDevitt -- Excitation-contraction coupling, functional properties, and autonomic and hormonal regulation in human embryonic stem cell derived cardiomyocytes / Oshra Sedan and Ofer Binah -- Embryonic stem cell derivatives for cardiac therapy : advantages, limitations, and long-term prospects / Michal Weiler-Sagie and Lior Gepstein -- Methods for differentiation of bone-marrow-derived stem cells into myocytes / Shinji Makino and Keiichi Fukuda -- Homing, survival, and paracrine effects of human mesenchymal stem cells / Sergey Doronin -- Bone marrow cell therapy after myocardial infarction : what have we learned from the clinical trials and where are we going? / Kai C. Wollert -- Evidence for the existence of resident cardiac stem cells / Isotta Chimenti ... [et al.] -- Multiple sources for cardiac stem cells and their cardiogenic potential / Antonio Paolo Beltrami, Daniela Cesselli, and Carlo Alberto Beltrami -- Skeletal muscle stem cells in the spotlight : the satellite cell / Zipora Yablonka-Reuveni and Kenneth Day -- Regenerating mechanical function in vivo with skeletal myoblasts / Todd K. Rosengart and Muath Bishawi -- Methods for inducing pluripotency / Raymond L. Page, Christopher Malcuit, and Tanja Dominko -- Inducible pluripotent stem cells for cardiac regeneration / Naama Zeevi-Levin and Joseph Itskovitz-Eldor -- Induced pluripotent cells for myocardial infarction repair / Timothy J. Nelson and Andre Terzic -- Substrates of cardiac reentrant arrhythmias : the possible role of tissue regeneration and replacement / André G. Kléber -- Integration of stem cells into the cardiac syncytium : formation of gap junctions / Peter R. Brink, Ira S. Cohen, and Richard T. Mathias -- Bradyarrhythmia therapies : the creation of biological pacemakers and restoring atrioventricular node function / Richard B. Robinson -- Tachyarrhythmia therapies : approaches to atrial fibrillation and postinfarction ventricular arrhythmias / J. Kevin Donahue and Kenneth R. Laurita -- Long-term prospects for arrhythmia treatment : advantages and limitations of gene and cell therapies / Michael R. Rosen -- Regenerating blood vessels / Tracy A. Gwyther and Marsha W. Rolle -- Regenerating heart valves / Benedikt Weber and Simon P. Hoerstrup -- Tissue engineering strategies for cardiac regeneration / Amandine F.G. Godier-Furnémont ... [et al.] -- Methods of cell delivery for cardiac repair / Sarah Fernandes and Hans Reinecke -- Tracking of stem cells in vivo / Yingli Fu and Dara L. Kraitchman -- Assessing regional mechanical function after stem cell delivery / Jacques P. Guyette and Glenn R. Gaudette.
  • Frontiers of spinal cord and spine repair : experimental approaches for repair of spinal cord injury / Choya Yoon and Mark H. Tuszynski -- Stem cell based strategies for spinal cord injury repair / Alexa Reeves and Hans S. Keirstead -- Strategies for endogenous spinal cord repair : HPMA hydrogel to recruit migrating endogenous stem cells / Araceli Espinosa-Jeffrey ... [et al.] -- Stem cells and spinal cord injury repair / Soheila Karimi-Abdolrezaee and Eftekhar Eftekharpour -- Chronic pain following spinal cord injury / Radi Masri and Asaf Keller -- Repair of radiation damage and radiation injury to the spinal cord / Timothy E. Schultheiss -- Malignancies of the spinal cord / J. Dawn Waters, Encarnacion Maria Navarro Peran, and Joseph Ciacci -- Molecular basis of intervertebral disc degeneration / Dipika Gopal ... [et al.] -- Bioceramics for osteogenesis, molecular and cellular advances / Hande Demirkiran -- Cell-based therapies for spinal fusion / Ronke Olabisi -- Clinical efficacy of stem cell mediated osteogenesis and bioceramics for bone tissue engineering / Josh Neman ... [et al.] -- Progenitor cells : role and usage in bone tissue engineering approaches for spinal fusion / Lonnissa H. Nguyen ... [et al.].
  • 1. Cell Therapy for Neurodegenerative Disorders / Ilyas Singec -- 2. New Prospects for Neural Stem Cell Therapies of Nervous System Diseases Toward the Establishment of Atypical Ectopic Perivascular Stem Cell Niches / Clara Alfaro-Cervello, Chiara Cossetti, Elena Giusto, Matteo Donegà and Stefano Pluchino -- 3. Cultured Limbal Epithelial Stem Cell Therapy for Ocular Surface Diseases / Hannah J. Levis, Julie T. Daniels and Sajjad Ahmad -- 4. Keratinocyte Stem Cells: Biology and Clinical Applications / Carlo Pincelli and Alessandra Marconi -- 5. Cardiac Regeneration with Stem Cells / Beatriz Pelacho, Manuel Mazo, Sheyla Montori, Ana Maria Simon-Yarza, Juan Jose Gavira, Maria J. Blanco-Prieto and Felipe Prósper -- 6. Development of Biological Approaches to Improve Muscle Healing After Injury and Disease / Jonathan D. Proto and Johnny Huard -- 7 Mesenchymal Stem Cells in Bone and Cartilage Regeneration / Mohamadreza Baghaban Eslaminejad, Elham Zomorodian and Fatemeh Bagheri -- 8. Pancreatic Reprogramming / Juan Domínguez-Bendala -- 9. Pancreatic Regeneration in the Face of Diabetes / Zeeshan Ahmad -- 10. Regenerative Therapies for Liver Diseases / Amar Deep Sharma, Ina Rittelmeyer, Tobias Cantz and Michael Ott -- 11. Clinical Studies of Cell Therapy for Liver Cirrhosis / James A. Thomas and Stuart J. Forbes -- 12. Stem Cell Applications for the Treatment of Gastrointestinal System Diseases / Jacobo Trebol Lopez, Tihomir Georgiev-Hristov, Mariano García-Arranz and Damián García-Olmo -- 13. Germ Line Stem Cells: A Promising Alternative Source for Stem-Cell-Based Therapies in Regenerative Medicine / Ellen Goossens and Herman Tournaye -- 14. Cord Blood Stem Cells and Regenerative Medicine / David T. Harris.
  • Principles of regenerative medicine and cell,tissue and organ bioengineering -- Kidney -- Liver -- Heart -- Small bowel -- Endocrine pancreas and islets of langerhans -- Lung -- Composite tissues allotranplantation -- Immunosuppression-free transplantation in the regenerative medicine era.
  • Regenerative medicine is at a pivotal point. Innovations in the science and the rapid growth of translational medicine are transforming the field just as institutional arrangements are changing, making this an exciting yet unsettled time. Recent court cases and policy initiatives are creating crosscurrents that keep older issues from being settled while introducing new dilemmas. Current research propels collaborations across disciplines and sectors, raising the question of how tensions between the protection of intellectual property and the movement toward "open science" can be negotiated. Other important social, ethical and legal questions arise in the gray areas created by new scientific techniques and pragmatic areas involved in scale-up and testing in humans. The times call for governance that is adaptive to meet the needs of science yet able to maintain public trust. The contributors address these and other vital questions through chapters focusing on topics such as data sharing; patenting of human biological material; and managing collaborations across academic, industry and government sectors as well as across national boundaries. Key research ethics issues are also included such as obtaining consent from biospecimen donors; accessing biorepository data, and considerations in designing preclinical and clinical trial protocols for first-in-human research, including upcoming policy changes. Rather than retracing well-trodden topics, the book points to nascent areas that need to be addressed. Whether working in academia, industry, or government, regenerative medicine scientists and managers need to know how to navigate current and upcoming issues of governance facing the field. Regenerative Medicine Ethics: Governing Research and Knowledge. Practices will be a valuable resource for scientists, policy-makers and students as they plan and execute responsible research.
  • The research described in this book represents important steps toward understanding the development of inner ear medicine and new perspectives in regenerative medicine, including efficacy in cochlear implants and various other treatments. The book depicts the mechanisms that underlie inner ear diseases, their experimental models, and proposals for new strategies to treat their symptoms. As well, the exciting future prospects for dealing with the very common problem of inner ear diseases are explained. These disorders occur among many people and include sensorineural hearing loss (SNHL), sudden deafness, senile deafness, noise-induced deafness, tinnitus, dizziness-vertigo, and Ménière's disease. In Japan alone, there are more than 6 million deaf patients including those with middle-range deafness. There is currently no effective treatment, and regardless of the underlying cause, the damage has been considered irreversible. However, the results of recent research show that these patients actually can recover. The study of hair cells, spiral ganglion neurons, and stem cells for inner ear diseases such as SNHL, tinnitus, dizziness, and vertigo is at the forefront of regenerative medicine and may provide solutions to some of these problems. The information presented here makes this book a valuable professional reference work for all doctors and researchers in the field of otolaryngology who focus on regenerative treatments for inner ear diseases.
  • This book represents a major contribution to the emerging science of regenerative medicine using non-fetal sources of stem cells. The Editors, Dr Niranjan Bhattacharya and Professor Phillip Stubblefield, have brought together some of the most pre-eminent scientists working on regenerative medicine to share information on currently ongoing work in this area alongside unpublished observations that will help to shape the contours of future therapies. Regenerative Medicine: Using Non-Fetal Sources of Stem Cells discusses the potential clinical and therapeutic applications using non-fetal stem cells as well as providing instruction on the collection, isolation and characterization of stem cells from various non-fetal sources, such as menstrual blood, adipose tissue, breast milk and uprooted decidual teeth. This book will be an invaluable resource for both active researchers and those entering the field. The Editors truly hope that the text will act as a stimulant to professionals and clinical scientists, who may be inspired to further the work of the pioneering scientists who have contributed to this volume.
  • A massive wastage of the global resources -- Placenta as a source of stem cells and as a key organ for fetomaternal tolerance -- Placenta and umbilical cord in traditional Chinese medicine -- Use of umbilical venous blood on assessing the biochemical variations of acid-base, nutritional and metabolic parameters on growth-retarded fetuses, in comparison with gestational control cases: a study -- Umbilical cord blood transfusion and its therapeutic potentialities -- Autologous placental blood transfusion for the therapy of anemic neonates -- Cord blood: a massive waste of a life-saving resource: a perspective on its current and potential uses -- Clinical experience of cord blood autologous transfusion -- Emergency use of human cord blood -- Hemoglobin-based oxygen carriers in trauma care: the US multicenter prehospital trial -- Placental umbilical cord blood as a true blood substitute with an edge -- Implications of feto-maternal cell transfer in normal pregnancy -- Early reports on the prognostic implications and immunotherapeutic potentials of Cd34 rich cord whole blood transfusion in advanced breast cancer with severe anemia -- Anti-inflammatory effects of human cord blood and its potential implications in neurological disorders -- Transforming "waste" into gold: identification of novel stem cells resources with therapeutic potential in neuromuscular disorders -- Human umbilical cord blood cells for stroke -- Placental umbilical cord blood transfusion for stem cell therapy in neurological diseases -- Umbilical cord and its blood: a perspective on its current and potential use in ophthalmology -- Umbilical vein grafts for lower limb revascularization -- Cord blood stem cells in angiogenesis. Endothelial progenitor cells from cord blood: magic bullets against ischemia? -- Therapeutic potential of placental umbilical cord blood in cardiology -- Stem cell therapy for heart failure using cord blood -- Human umbilical cord blood mononuclear cells in the treatment of acute myocardial infarction -- Umbilical cord-derived mesenchymal stem cells -- Cord blood stem cell expansion ex vivo: current status and future strategies -- Embryonic-like stem cells and the importance of human umbilical cord blood for regenerative medicine -- Use of non-hematopoietic stem cells of fetal origin from cord blood, umbilical cord, and placenta in regeneration medicine -- Animal studies of cord blood and regeneration -- Immune privilege of cord blood -- Combination cellular therapy for regenerative medicine: the stem cell niche -- Use of cord blood in regenerative medicine -- Comparisons between related and unrelated cord blood collection and/or banking for transplantation or research: the UK NHS blood and transplant experience -- Donor and collection-related variables affecting product quality in ex utero cord blood banking -- Cord blood as a source of hematopoietic progenitors for transplantation -- Amniotic fluid and placenta stem cells -- Use of amniotic membrane, amniotic fluid, and placental dressing in advanced burn patients -- Clinical use of amniotic fluid in osteoarthritis: a source of cell therapy -- A study and follow-up (1999-2009) of human fetal neuronal tissue transplants at a heterotopic site outside the brain in cases of advanced idiopathic Parkinsonism -- Ethical issues surrounding umbilical cord blood donation and banking.
  • 2011 ClinicalKey
    Chapter 1. Glomerulogenesis and De Novo Nephrogenesis in Medaka Fish: An Evolutionary Approach / Hisashi Hashimoto, Yuko Wakamatsu -- Chapter 2. Renal Organogenesis: Growing a Replacement Kidney In Situ from Transplanted Renal Primordia / Marc R. Hammerman -- Chapter 3. Use of Genetic Mouse Models to Study Kidney Regeneration / Akio Kobayashi, Jeremy S. Duffield -- Chapter 4. Endogenous Anti-inflammatory and Proresolving Lipid Mediators in Renal Disease / Charles N. Serhan, Catherine Godson -- Chapter 5. Tissue Protection and Regeneration Aided by Erythropoietin and Erythropoietin-derived Peptides / Danilo Fliser -- Chapter 6. Mast Cells in Kidney Regeneration / Eric Daugas, Walid Beghdadi, Ulrich Blank -- Chapter 7. Role of Macrophages in Renal Injury, Repair and Regeneration / Vincent Lee, Qi Cao, Yiping Wang, David C.H. Harris -- Chapter 8. T-cell Contribution to Injury and Regenerative Processes in Kidney Diseases: Focus on Regulatory T Cells / Hye Ryoun Jang, Hamid Rabb -- Chapter 9. Mesenchymal Stem Cells / Benjamin D. Humphreys, Joseph V. Bonventre -- Chapter 10. Endothelial Progenitor Cells and the Kidney / Matthieu Monge, Anton Jan van Zonneveld, Ton J. Rabelink -- Chapter 11. Potential of the Side Population in Regenerative Nephrology / M.H. Little, G.A. Challen -- Chapter 12. Very Small Embryonic-like Stem Cells and Their Potential Relevance for Kidney Homeostasis / Dong-Myung Shin, Rui Liu, Przemyslaw Nowacki, Janina Ratajczak, Magda Kucia, Mariusz Z. Ratajczak -- Chapter 13. Induced Pluripotent Stem Cells / Kenji Osafune, Shinya Yamanaka -- Chapter 14. Methods of Isolation and Culture of Adult Stem Cells / Lindolfo da Silva Meirelles, Nance Beyer Nardi -- Chapter 15. Stem Cell Niche in the Kidney / Laura Lasagni, Elena Lazzeri, Paola Romagnani -- Chapter 16. Bioartificial Stem Cell Niches: Engineering a Regenerative Microenvironment / Glenn D. Prestwich, Tammer Ghaly, Philip Brudnicki, Brian Ratliff, Michael S. Goligorsky -- Chapter 17. Imaging of Transplanted and Native Stem Cells / Xiang-Yang Zhu, Martin Rodriguez-Porcel, Lilach O. Lerman -- Chapter 18. Stem Cell Injury and Premature Senescence / Michael S. Goligorsky -- Chapter 19. Regeneration and Aging: Regulation by Sirtuins and the NAD+ Salvage Pathway / Nica M. Borradaile, Alanna Watson, J. Geoffrey Pickering -- Chapter 20. Bone Marrow Mesenchymal Stem Cells in Organ Repair and Strategies to Optimize their Efficacy / Christodoulos Xinaris, Barbara Imberti, Giuseppe Remuzzi, Marina Morigi -- Chapter 21. Treatment of Acute Kidney Injury with Allogeneic Mesenchymal Stem Cells: Preclinical and Initial Clinical Data / Florian E. Tögel, Christof Westenfelder -- Chapter 22. Clinical Trials in Renal Regenerative Medicine / Maarten B. Rookmaaker, Jaap A. Joles, Marianne C. Verhaar -- Chapter 23. Potential Risks of Stem Cell Therapies / Uta Kunter, Jürgen Floege -- Chapter 24. Tissue Engineering in Urology / Anthony Atala -- Chapter 25. Ethics in Regenerative Medicine / Svetlana Gavrilov, Donald W. Landry -- Chapter 26. Stem Cell Banking / Vicente Mirabet, Pilar Solves.
  • "Regenerative medicine is broadly defined as the repair or replacement of damaged cells, tissues, and organs. It is a multidisciplinary effort in which technologies derive from the fields of cell, developmental, and molecular biology; chemical and material sciences (i.e., nanotechnology); engineering; surgery; transplantation; immunology; molecular genetics; physiology; and pharmacology. As regenerative medicine technologies continue to evolve and expand across the boundaries of numerous scientific disciplines, they remain at the forefront of the translational research frontier with the potential to radically alter the treatment of a wide variety of disease and dysfunction. The goal of this book is to draw attention to the critical role that the pharmacological sciences will undeniably play in the advancement of these treatments. This book is invaluable for advanced students, postdoctoral fellows, researchers new to the field of regenerative medicine/tissue engineering, and experienced investigators looking for new research avenues. This is the first state-of-the-art book in this rapidly evolving field of research"--Provided by publisher.
  • Print Material
    From bioplastics to H. sapiens 2.0 -- -3,800 Myr, Late Hadean : at the inorganic/organic interface -- -3,500 Myr, Archean : reading the most ancient texts and the future of living software -- -500 Myr, Cambrian : the mirror world and the explosion of diversity ; How fast can evolution go and how diverse can it be? -- -360 Myr, Carboniferous : "the best substitute for petroleum is petroleum" -- -60 Myr, Paleocene : emergence of mammalian immune system ; Solving the health care crisis through genome engineering -- -30,000 Yr, Pleistocene Park : engineering extinct genomes -- -10,000 Yr, Neolithic : industrial revolutions ; The agricultural revolution and synthetic genomics ; The BioFab Manifesto -- -100 Yr, Anthropocene : the third industrial revolution ; iGEM -- -1 Yr, Holocene : from personal genomes to immortal human components -- Epigenetic epilogue. +1 Yr, the end of the beginning, transhumanism, and the Panspermia Era : societal risks and countermeasures.
  • Print Material
    [v. 1] The upper extremity -- [v. 2] The neck and head -- [v. 3] The abdomen and pelvis -- [v. 4] The thorax and back.
  • Print Material
    pt. 1. Head and neck -- pt. 2. Thoracic limb -- pt. 3. Pelvic limb -- pt. 4. Thorax and abdomen.
  • "Never before has essential guidance been so quick and convenient to access on the go! "Regional Anesthesia and Pain Management: Handbook and iPod" truly puts the answers you need at your fingertips. Under the superb leadership of Series Editor Lee A. Fleisher, MD, experts from the University of Pennsylvania present practical coverage of regional anesthesia and pain management in a concise, at-a-glance manner. A consistent, bulleted format and concise images make it remarkably easy to review and learn even the most difficult procedures and quickly resolve thorny clinical questions. Whether you consult the pocket-sized handbook, or download the content onto your standard click-wheel iPod, you'll be amazed how easy it is to look up vital information quickly."--Publisher's website.
  • Various applications in the field of pulmonary image analysis require a registration of CT images of the lung. For example, a registration-based estimation of the breathing motion is employed to increase the accuracy of dose distribution in radiotherapy. Alexander Schmidt-Richberg develops methods to explicitly model morphological and physiological knowledge about respiration in algorithms for the registration of thoracic CT images. The author focusses on two lung-specific issues: on the one hand, the alignment of the interlobular fissures and on the other hand, the estimation of sliding motion at the lung boundaries. He shows that by explicitly considering these aspects based on a segmentation of the respective structure, registration accuracy can be significantly improved.
  • This User's Guide is intended to support the design, implementation, analysis, interpretation, and quality evaluation of registries created to increase understanding of patient outcomes. For the purposes of this guide, a patient registry is an organized system that uses observational study methods to collect uniform data (clinical and other) to evaluate specified outcomes for a population defined by a particular disease, condition, or exposure, and that serves one or more predetermined scientific, clinical, or policy purposes. A registry database is a file (or files) derived from the registry. Although registries can serve many purposes, this guide focuses on registries created for one or more of the following purposes: to describe the natural history of disease, to determine clinical effectiveness or cost-effectiveness of health care products and services, to measure or monitor safety and harm, and/or to measure quality of care. Registries are classified according to how their populations are defined. For example, product registries include patients who have been exposed to biopharmaceutical products or medical devices. Health services registries consist of patients who have had a common procedure, clinical encounter, or hospitalization. Disease or condition registries are defined by patients having the same diagnosis, such as cystic fibrosis or heart failure.
  • Introduction -- Exploratory and descriptive methods -- Basic statistical methods -- Linear regression -- Predictor selection -- Logistic regression -- Survival analysis -- Repeated measures analysis -- Generalized linear models -- Complex surveys -- Summary.
  • Review of fundamental of statistics -- Bivariate linear regression and correlation -- Misspecified disturbance terms -- Nonparametric regression -- Logistic regression -- Bayesian regression -- Robust regression -- Fuzzy regression -- Random coefficients regression -- L1 and q-Quantile regression -- Regression in a spatial domain -- Multiple regression -- Normal correlation models -- Ridge regression -- Indicator variables -- Polynomial model estimation -- Semiparametric regression -- Nonlinear regression -- Issues in time series modeling and estimation.
  • Time series following generalized linear models -- Regression models for binary time series -- Regression models for categorical time series -- Regression models for count time series -- Other models and alternative approaches -- State space models -- Prediction and interpolation -- Appendix: Elements of stationary processes.
  • Examining the molecular mechanism of Bcl-2 family proteins at membranes by fluorescence spectroscopy -- Photoreactive stapled peptides to identify and characterize BCL-2 family interaction sites by mass spectrometry -- The structural biology of BH3-only proteins -- How to analyze mitochondrial morphology in healthy cells and apoptotic cells in Caenorhabditis elegans -- Apoptosis initiation through the cell-extrinsic pathway -- Using RNAi screening technologies to interrogate the extrinsic apoptosis pathway -- Caspase enzymology and activation mechanisms -- Turning on caspases with genetics and small molecules -- A multipronged approach for compiling a global map of allosteric regulation in the apoptotic caspases -- Measuring caspase activity in vivo -- Single-molecule sensing of caspase activation in live cells via plasmon coupling nanotechnology -- In vivo monitoring of caspase activation using a fluorescence resonance energy transfer-based fluorescent probe -- Global analysis of cullular proteolysis by selective enzymatic labelling of protein N-termini -- Complementary methods for the indentification of substrates of proteolysis -- Phospholipid scrambling on the plasma membrane -- Studying apoptosis in the zebrafish.
  • AAA+ proteolytic machines -- Machines of destruction: AAA+ proteases and the adaptors that control them / Eyal Gur, Ralf Ottofueling, David A. Dougan -- The Lon AAA+ protease / Eyal Gur -- FtsH protease-mediated regulation of various cellular functions / Takashi Okuno, Teru Ogura -- Regulatory proteolysis in bacteria -- General and regulatory proteolysis in Bacillus subtilis / Nöel Molière, Kürşad Turgay -- Proteolytic regulation of stress response pathways in Escherichia coli / Dimce Micevski, David A. Dougan -- Regulated proteolysis: control of the Escherichia coli [sigma]E-dependent cell envelope stress response / Sarah E. Barchinger, Sarah E. Ades -- Bacterial proteases and virulence / Dorte Frees, Lone Brøndsted, Hanne Ingmer -- Regulated proteolysis in yeast -- Roles of Cdc48 in regulated protein degradation in yeast / Alexander Buchberger -- The Role of AAA+ proteases in mitochondrial protein biogenesis, homeostasis and activity control / Wolfgang Voos, Linda A. Ward, Kaye N. Truscott -- Ubiquitin-like protein modification and protein degradation in microorganisms -- The pup-proteasome system of mycobacterium tuberculosis / Marie I. Samanovic, Huilin Li, K. Heran Darwin -- Archaeal proteasomes and sampylation / Julie A. Maupin-Furlow.
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  • Micro mining : computational approaches to miRNA discovery / Adam Grundhoff -- Animal microRNA gene prediction / Ola Snv?e and Pa<U+030a>l St?rom -- A suite of resources for the study of miRNA ontology and function / Praveen Sethupathy, Molly Megraw, and Artemis G. Hatzigeorgiou -- Regulation of translation and mRNA stability by Hfq-binding small RNAs in Escherichia coli / Hiroji Aiba -- Mechanisms by which microRNAs regulate gene expression in animal cells / Yang Yu and Timothy W. Nilsen -- The microRNAs of C. elegans / Mona J. Nolde and Frank J. Slack -- Isolation and characterization of small RNAs in C. elegans / Chisato Ushida and Yusuke Hokii -- MicroRNA tales in fly development / Utpal Bhadra ... [et al.] -- RNA interference and miRNAs in zebrafish / Alex S. Flynt, Elizabeth J. Thatcher, and James G. Patton -- Biogenesis and function of plant microRNAs / Zoltan Havelda -- Endogenous small RNA pathways in Arabidopsis / Manu Agarwal, Julien Curaba, and Xuemei Chen. How to assay miRNA expression : a technology guide / Mirco Castoldi, Vladimir Benes, and Martina U. Muckenthaler -- Methods to quantify microRNA gene expression / Lori A. Neely -- Regulation of alternative splicing by microRNAs / Rajesh K. Gaur -- Recent progress in polymerase II-mediated intronic microRNA expression systems / Shi-Lung Lin and Shao-Yao Ying -- MicroRNA-based RNA polymerase II expression vectors for RNA interference in mammalian cells / Anne B. Vojtek ... [et al.] -- Transgenic RNAi : a fast and low-cost approach to reverse genetics in mammals / Linghua Qiu and Zuoshang Xu -- Symphony of AIDS : an miRNA-based therapy / Yoichi R. Fujii -- MicroRNAs and cancer : connecting the dots / Sumedha D. Jayasena -- Mammalian transcriptional gene silencing by small RNAs / Daniel H. Kim and John J. Rossi -- Regulation of gene expression by RNA mediated transcriptional gene silencing / Kevin V. Morris.
  • MicroRNA biogenesis and function : an overview / Rene F. Ketting -- Regulation of pri-miRNA processing through Smads / Akiko Hata and Brandi N. Davis -- Stimulation of pri-miR-18a processing by hnRNP A1 / Gracjan Michlewski, Sonia Guil, and Javier F. Cáceres -- KSRP promotes the maturation of a group of miRNA precursors / Michele Trabucchi ... [et al.] -- Hormonal repression of miRNA biosynthesis through a nuclear steroid hormone receptor / Sally Fujiyama-Nakamura, Kaoru Yamagata, and Shigeaki Kato -- Autoregulatory mechanisms controlling the microprocessor / Robinson Triboulet and Richard I. Gregory -- Regulation of pre-miRNA processing / Nicolas J. Lehrbach and Eric A. Miska -- The effect of RNA editing and ADARs on miRNA biogenesis and function / Bret S.E. Heale, Liam P. Keegan, and Mary A. O'Connell -- MiRNAs need a trim regulation of miRNA activity by trim-NHL proteins / F. Gregory Wulczyn ... [et al.] -- Properties of the regulatory RNA-binding protein HuR and its role in controlling miRNA repression / Nicole-Claudia Meisner and Witold Filipowicz -- Turnover of mature miRNAs and siRNAs in plants and algae / Heriberto Cerutti and Fadia Ibrahim -- MicroRNases and the regulated degradation of mature animal miRNAs / Helge Grosshans and Saibal Chatterjee.
  • pt. B ScienceDirect
  • Regulatory RNAs 2006
    Cold Spring Harb Lab Press
    Mechanism and biology of RNAi -- Genome-wide approaches -- Small RNAs in development -- Telomeres and cancer -- End regulation of transcripts -- RNPs and RNA editing -- Biology of short RNAs -- Control of gene expression by noncoding RNAs -- Heterochromatin -- Quality control, messenger RNA turnover, and translational control.
  • pt. 1. Basics -- pt. 2. Methods -- pt. 3. Applications.
  • This book provides a comprehensive and up-to-date collection of review articles focusing on RNA-mediated regulation in prokaryotes. The various modes of action include the direct interaction with proteins, direct sensing of metabolites or of physical parameters, and the interaction with RNAs to stimulate or prevent binding of ribosomes or to stimulate degradation. Written by leading experts in the field, the book covers small RNA functions, RNA thermometers, riboswitches, the diversity of small RNA-guided CRISPR-Cas defense systems and selected RNA chaperons in both prokaryotic domains, bacteria and archaea. Recent advances towards the computational identification of regulatory RNAs and their targets are included and particular attention is paid to small RNA in pathogenic bacteria. This volume is the only one exclusively covering regulatory RNAs in the prokaryotic domains to date, making it essential literature for anyone interested in RNA function and gene regulation and a valuable resource for teaching these concepts.
  • "Designed in a concise, easy-to-read style for a wide variety of medical occupations, the Rehab Clinical Pocket Guide is the ideal, handy reference for rehabilitation professionals and other health providers. Divided into four sections that cover inpatient care, clinical strategies, outpatient care, and additional diagnostics and therapeutics, this is the first book of its kind to contain all of the relevant clinical information needed on the rehabilitation unit, including specific admission order sets and topics such as medication dosing, consultant recommendations, specific rehabilitation goals and treatments, and even billing details for various diagnoses. The Rehab Clinical Pocket Guide offers all the clinical material needed to properly treat patients and excel in the field of physical medicine and rehabilitation and will prove an indispensable resource for medical students, residents, physicians, therapists and nutritionists."--P. 4 of cover."
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  • Vol. 1. Anantomy and Kinesiology -- Examination -- Skin and Soft Tissue Conditions -- Hand Fractures and Joint Injuries -- Tendon Injuries and Tendinopathies -- Nerve Lacerations -- Compression Neuropathies -- Proximal Nerve Conditions -- Surgical Reconstruction for Nerve Injuries -- Vascular and Lymphatic Disorders -- Stiffness of the Hand -- Vol. 2. Common Wrist Injuries -- Common Elbow Injuries -- Common Shouler Conditions -- Complex Traumatic Conditions -- Arthritis and Related Autoimmune Disorders -- Pain -- Special Techniques of Therapist's Intervention -- Orthotic Intervention: Principles and Techniques -- Other Special Populations -- The Injured Worker -- Evidenced-Based Practice: Integrating Clinical Expertise and Systematic Research.
  • Outcome measurement and practice -- International classification of functioning, disability and health (ICF) -- How to choose an outcome measure -- Reliability : error in measurement -- Validity -- Measuring change -- Measuring mobility -- Measuring physical activity -- Measuring fatigue -- Measuring neurological conditions and rehabilitation -- Evaluating satisfaction.
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    Americans with Disabilities Act and accessibility issues (including wheelchair information) -- Musculoskeletal anatomy, orthopedics, and orthopedic therapy -- Neuroanatomy, neurology, and neurologic therapy -- Pulmonary anatomy and pulmonary therapy -- Vascular anatomy, cardiology, and cardiac rehabilitation -- Pediatrics -- Geriatrics -- Measurement, assessment, and outcomes -- Kinesiology and gait -- Prosthetics and orthotics -- Psychology and psychiatry -- Electromagnetic, thermal modalities, and electrotherapy -- Massage and soft tissue techniques -- General medicine (including oncology and AIDS) -- Pharmacology -- Burns -- Reference tables and conversion charts -- Translations : useful expressions.
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    "Bringing together the experience, perspective and expertise of Paul Farmer, Jim Yong Kim, and Arthur Kleinman, Reimagining Global Health provides an original, compelling introduction to the field of global health. Drawn from a Harvard course developed by their student Matthew Basilico, this work provides an accessible and engaging framework for the study of global health. Insisting on an approach that is historically deep and geographically broad, the authors underline the importance of a transdisciplinary approach, and offer a highly readable distillation of several historical and ethnographic perspectives of contemporary global health problems.The case studies presented throughout Reimagining Global Health bring together ethnographic, theoretical, and historical perspectives into a wholly new and exciting investigation of global health. The interdisciplinary approach outlined in this text should prove useful not only in schools of public health, nursing, and medicine, but also in undergraduate and graduate classes in anthropology, sociology, political economy, and history, among others"--Provided by publisher.
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    Analytic framework / Lu Ann Aday -- Fundamental determinants of population health / Kathryn M. Cardarelli ... [et al.] -- Sustainable development / Sondip K. Mathur, Carl S. Hacker, Lu Ann Aday -- Human development / Barbara J. Low ... [et al.] -- Economic development / Luisa Franzini ... [et al.] -- Community development and public health / Cynthia Warrick ... [et al.] -- Toward a healthy (re)public / Lu Ann Aday ... [et al.].
  • Relational competence the set of traits that allow people to interact with each other effectively enjoys a long history of being recorded, studied, and analyzed. Accordingly, Relational Competence Theory (RCT) complements theories that treat individuals' personality and functioning individually by placing the individual into full family and social context. The ambitious volume Relational Competence Theory: Research and Mental Health Applications opens out the RCT literature with emphasis on its applicability to interventions, and updates the state of research on RCT, examining what is robust and verifiable both in the lab and the clinic. The authors begin with the conceptual and empirical bases for the theory, and sixteen models demonstrate the range of RCT concerns and their clinical relevance, including: socialization settings for relational competence, the ability to control and regulate the self, relationship styles, intimacy and negotiation, the use of practice exercises in prevention and treatment of pathology, appendices featuring the Relational Answers Questionnaire and other helpful tools. Relational Competence Theory both challenges and confirms much of what we know about the range of human relationships, and is important reading for researchers, scholars, and students in personality and social psychology, psychotherapy, and couple and family counseling.
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    Relaxin and related peptides in male reproduction / Alexander I. Agoulnik -- The vascular actions of relaxin / Arundhathi Jeyabalan ... [et al.] -- The effects of relaxin on extracellular matrix remodeling in health and fibrotic disease / Chrishan S. Samuel, Edna D. Lekgabe, and Ishanee Mookerjee -- Relaxin-like ligand receptor systems: are autocrine/paracrine effectors in tumor cells and modulate cancer: progression and tissue invasiveness / Thomas Klonisch ... [et al.] -- Relaxin family peptide and receptor systems in brain: insights from recent anatomical and functional studies / Sherie Ma and Andrew L. Gundlach. The evolution of the relaxin peptide family and their receptors / Tracey N. Wilkinson and Ross A.D. Bathgate -- Relaxin, the relaxin-like factor and their receptors / Christian Schwabe and Erika E. Büllesbach -- Diverse signalling mechanisms used by relaxin in natural cells and tissues: the evolution of a "neohormone" / Richard Ivell, Kee Heng, and Ravinder Anand-Ivell -- Relaxin physiology in the female reproductive tract during pregnancy / Laura J. Parry and Lenka A. Vodstrcil --
  • Introduction -- Adaptation and contraction theory for the synchronization of complex neural networks -- Temporal coding is not only about cooperation, it is also about competition -- Using non-oscillatory dynamics to disambiguate pattern mixtures -- Functional constraints on network topology via generalized sparse -- Evolution of time in neural networks, from the present to the past, and forward to the future -- Synchronization of coupled pulse-type hardware neuron models for CPG model -- A univesal abstract-time platform for real-time neural networks -- Solving complex control tasks via simple rule(s), using chaotic dynamics in a recurrent neural network model -- Time scale analysis of neuronal ensemble data used to feed neural network models -- Simultaneous EEG-fMRI, integrating spatial and temporal resolution -- Erratum to: Time scale analysis of neuronal ensemble data used to feed neural network models.
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    "Cognitive neuroscientists increasingly claim that brain images generated by new brain imaging technologies reflect, correlate, or represent cognitive processes. In this book, William Uttal warns against these claims, arguing that, despite its utility in anatomic and physiological applications, brain imaging research has not provided consistent evidence for correlation with cognition. Uttal bases his argument on an extensive review of the empirical literature, pointing to variability in data not only among subjects within individual experiments but also in the new meta-analytical approach that pools data from different experiments. This inconsistency of results, he argues, has profound implications for the field, suggesting that cognitive neuroscientists have not yet proven their interpretations of the relation between brain activity captured by macroscopic imaging techniques and cognitive processes; what may have appeared to be correlations may have only been illusions of association. He supports the view that the true correlates are located at a much more microscopic level of analysis: the networks of neurons that make up the brain." -- [Publisher-supplied data]
  • Basic mathematical concepts -- Introduction to reliability technology, human error, and quality -- Medical device safety and quality assurance -- Medical device software quality assurance and risk assessment -- Medical device maintenance and sources for obtaining medical device-related failure data -- Human error in health care -- Health care human error reporting systems and models for predicting human reliability and error in health care -- Patient safety -- Introduction to quality in health care -- Quality methods for use in health care.
  • 1. Introduction -- 2. Pain as a Public Health Challenge -- 3. Care of People with Pain -- 4. Education Challenges -- 5. Research Challenges -- 6. A Blueprint for Transforming Pain Prevention, Care, Education, and Research -- Glossary -- A. Data Sources and Methods -- B. Summary of Written Public Testimony -- C. The Economic Costs of Pain in the United States -- D. Committee and Staff Biographies.
  • Defining and Assessing Competence -- An Example of a Remediation Program -- 'She Needs to Read More': Helping trainees who struggle with medical knowledge -- Remediation of Interpersonal and Communication Skills -- Remediation of Physical Exam Skills -- Assessing and Remediating Clinical Reasoning -- Remediating Lapses in Professionalism -- 'You said, I heard': Speaking the subtext in interracial conversations -- Learning Differences and Medical Education -- 'Well, This Is Awkward': Autism Spectrum Disorder in Medical Trainees -- Stress and Distress and Wellness -- Perspectives from a Psychiatrist in an Office of Advising Resources -- The Metacognitive Competency: The key to life-long learning -- Use of Reflection as a Remediation Tool -- Feedback -- Appreciative Coaching: A positive process for remediation -- Preparing Program Directors to Address Unprofessional Behavior -- The View from the Dean's Office -- Preparing to Conduct Remediation -- 'The Prognosis is Poor': When to give up -- A Research Agenda for the Field of Remediation -- Epilogue: A Student's Perspective on Remediation.
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  • Epidemiology, Screening, and Clinical Staging / Michael J. Lipsky, Christopher M. Deibert -- Molecular Biology and Genetics / Jeff Klomp, Karl Dykema, Bin Tean Teh, Kyle Furge -- Familial and Hereditary Syndromes / Brian Shuch, Peter Pinto -- Pathology of Renal Cell Carcinoma / Fang-Ming Deng, Jonathan Melamed, Ming Zhou -- Imaging of Renal Cancer / Jalil Afnan, Christoph Wald -- Molecular Imaging for Renal Cell Carcinoma / Jian Q. Yu, Yamin Dou -- History of Renal Surgery for Cancer / Kamal Nagpal, Karim Hamawy -- Natural History, Role of Biopsy, and Active Surveillance of Renal Masses / Anthony T. Corcoran, Marc C. Smaldone, Robert G. Uzzo -- Interventional Radiology and Angioinfarction: Transcatheter Embolization of Renal Tumors / Sebastian Flacke, Shams Iqbal -- Unified Approaches to Surgery and Systemic Therapy for Renal Cell Carcinoma / Patrick A. Kenney, Christopher G. Wood -- Rationale for Partial Nephrectomy / Nicholas Donin, William Huang -- Objectifying Complexity of Kidney Cancers: Relationships of Tumor Anatomy and Outcomes / Serge Ginzburg, Alexander Kutikov, Robert G. Uzzo -- Open Partial Nephrectomy / Patrick A. Kenney, Matthew F. Wszolek, John A. Libertino -- Minimally Invasive Partial Nephrectomy and Ablative Procedures for Small Renal Masses / Casey G. Kowalik, David Canes, Ali Moinzadeh -- Surgery for Renal Cell Carcinoma with Thrombus Extension into the Vena Cava / Chad Wotkowicz, John A. Libertino -- Role of Lymphadenectomy / Prof. Dr. Hein Van Poppel -- Postoperative Surveillance Protocols for Renal Cell Carcinoma / Megan M. Merrill., Jose A. Karam -- Role of Surgery in Locally Recurrent and Metastatic Renal Cancer / Paul Russo -- Outcomes: Prognostic Factors, Models, and Algorithms / Brandon K. Isariyawongse, Michael W. Kattan -- Adjuvant Systemic Therapy, Immunotherapy, and Targeted Treatment / Linda Cerbone, Cora N. Sternberg -- Role for Radiation Therapy in Renal Cancer / Andrea McKee, Arul Mahadevan, Timothy Walsh -- Surgical Management for Transitional Cell Carcinoma of the Upper Tract / Jason R. Gee -- Management of Non-clear Cell Renal Cell Carcinoma / Henry J. Conter, Jose A. Karam, Nizar M. Tannir.
  • Part 1. Localized Disease -- Etiology of Renal Cell Carcinoma: Incidence, Demographics, and Environmental Factors / Frédéric D. Birkhäuser, Nils Kroeger and Allan J. Pantuck -- Pathology of Renal Cell Carcinoma / Ming Zhou and Huiying He -- Familial Renal Cell Carcinoma / Simon P. Kim and Bradley C. Leibovich -- Imaging of Renal Cell Carcinoma / Andrei S. Purysko, Erick M. Remer and Brian R. Herts -- Prognostic Factors for Localized Renal Cell Carcinoma / Brian R. Lane -- Part 2. Management of Localized RCC -- Assessment of Oncologic Risk for Clinical Stage T1 Renal Tumors and the Emerging Role of Renal Mass Biopsy / Matthew N. Simmons and Steven C. Campbell -- Radical Nephrectomy for Localized Renal Tumors: Optimum Oncological and Renal Functional Considerations / Paul Russo -- Nephron-Sparing Surgery for Renal Cancer / Alon Z. Weizer, Jeffery S. Montgomery and Khaled S. Hafez -- Thermal Ablation / Surena F. Matin and Kamran Ahrar -- Active Surveillance of the Small Renal Mass / Marc C. Smaldone, Daniel Canter, Alexander Kutikov and Robert G. Uzzo -- Part 3. Locally Advanced Disease -- Locally Advanced Renal Cell Carcinoma / Stephen H. Culp and Christopher G. Wood -- Neoadjuvant Targeted Therapy and Consolidative Surgery / Sean P. Stroup and Ithaar H. Derweesh -- Part 4. Advanced Disease -- Biology of Renal Cell Carcinoma (Vascular Endothelial Growth Factor, Mammalian Target of Rapamycin, Immune Aspects) / Alexandra Arreola and W. Kimryn Rathmell -- Prognostic Factors in Advanced Renal Cell Carcinoma / Michael M. Vickers and Daniel Y. C. Heng -- Integration of Surgery in Metastatic Renal Cancer / Tom Powles and Axel Bex -- Immunotherapy for Renal Cell Carcinoma / Diwakar Davar, Moon Fenton and Leonard J. Appleman -- Targeted Therapy: Vascular Endothelial Growth Factor / Linda Cerbone and Cora N. Sternberg -- Mammalian Target of Rapamycin in Renal Cell Carcinoma / Eric Jonasch and Michel Choueiri -- Palliative and Supportive Care for Renal Cancer / Armida Parala-Metz and Mellar Davis.
  • Pt. 1. Biology of renal cell carcinoma -- pt. 2. Current and future molecular targets for RCC.
  • This book examines renal pathophysiology and the rationale for renal denervation (RDN), a minimally invasive, endovascular catheter based procedure using radiofrequency ablation for the treatment of resistant hypertension, a leading cause of morbidity and mortality in western civilization. In addition, the possible long term benefits and risks of this new therapy are discussed together with a description of the myriad of currently available devices and approaches involved in the evolution of this treatment. Lastly, the book focuses on the cost effectiveness of renal denervation and future directions for other possible benefits. Written by world renowned leaders in the field, Renal Denervation will be of immediate use to cardiologists, nephrologists and urologists as well as allied health professionals, device companies and anyone working in this field.
  • Renal Disease in Cancer Patients is a translational reference detailing the nephrological problems unique to patients with cancer in an organized and authoritative fashion. This book provides a common language for nephrologists, oncologists, hematologists, and other clinicians who treat cancer patients, to discuss the development of renal diseases in the context of cancer and options for their optimum diagnosis, management, and treatment. With the advent of better supportive care and the era of personalized medicine, patients with cancer are living longer, and oncologists and nephrologists now recognize the serious consequences of renal disease among these patients. Designed especially with this new need in mind, Renal Disease in Cancer Patients presents the various renal diseases affecting cancer patients in a single, authoritative volume. The book covers topics in radiation nephritis, obstructive nephropathy, drug nephropathy, graft-versus-host disease, and more. Covers clinical description, diagnostics, management, and treatment throughout along with genetics, animal models, and pathology in specific chaptersSummarizes all renal diseases unique to cancer patients in a single reference. Provides a resource for oncologists and nephrologists, as well as general internal and family medicine practitioners, and physicians in training.
  • Assessment of Renal Function / Mohan Arkanath -- Imaging of Acute Renal Failure - A Problem-Solving Approach for Intensive Care Unit Physicians / Tom Sutherland -- Drug-Induced Renal Injury / Sara Blakeley -- Acute Kidney Injury / Sara Blakeley -- Medical Management of Acute Renal Failure / Nerina Harley -- Acute Renal Failure in the Surgical Patient / Marlies Ostermann -- Rhabdomyolysis and Compartment Syndrome / Laurie Tomlinson and Stephen Holt -- Multisystem Causes of Acute Renal Failure / Tim Leach -- Therapeutic Plasma Exchange / Tim Leach -- Renal Replacement Therapy / John H. Reeves -- Technical Aspects of Renal Replacement Therapy / Sara Blakeley -- End-Stage Renal Disease / Emile Mohammed -- Clinical Hyperkalemia and Hypokalemia / Harn-Yih Ong -- Clinical Hyponatremia and Hypernatremia / Himangsu Gangopadhyay -- Clinical Metabolic Acidosis and Alkalosis / Sara Blakeley.
  • Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis provides a comprehensive review of cytology and all the morphologic correlates, including their respective limitations, related to a broad spectrum of renal neoplasms with special emphasis on cyto-histo correlation. The book also discusses related usual radiologic appearances, gross features and possible targeted therapies where appropriate. The volume features an integrated approach that provides step-by-step guidance in the morphologic evaluation of renal neoplasms. Furthermore, all chapters are written by experts who deal with this type of specimen in their daily practice and have insights into the pathology as well as the clinical aspects of these tumors. Illustrated with high quality color microphotographs and formatted for ease of use in the lab, Renal Neoplasms: An Integrative Approach to Cytopathologic Diagnosis is a helpful guide to everyday pathology practice, especially for pathologists who rarely encounter this type of specimen.
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    Review of renal physiology -- Regulation of salt and water balance -- Disorders of water balance : hyponatremia, hypernatremia, and polyuria -- Edematous states and the use of diuretics -- Acid-base physiology and metabolic alkalosis -- Metabolic acidosis -- Disorders of potassium balance -- Urinalysis and approach to the patient with renal disease -- Pathogenesis of major glomerular and vascular diseases -- Progression of chronic renal failure -- Acute renal failure -- Signs and symptoms of chronic renal failure -- Tubulointerstitial diseases.
  • As the population of patients with acute or chronic kidney disease grows, healthcare professionals need a resource that optimizes drug effectiveness while minimizing potential toxicity. Renal Pharmacotherapy is a comprehensive listing of dosage recommendations for patients with compromised renal function. This up-to-date and evidence-based reference closes several identified knowledge gaps concerning medications eliminated by the kidneys. Conveniently listed alphabetically by generic drug name, each drug has its own face page featuring typical dosing ranges, alternative dosing adjustments by strata of renal function, specific dosing for dialysis and other dosing schemes.This work will satisfy the dosing information needs of busy physicians involved in pharmacotherapy for patients with kidney disease, as well as pharmacists, nurses and students.
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  • Physiology of body fluids -- Structure and function of the kidneys -- Glomerular filtration and renal blood flow -- Renal transport mechanisms: NaCI and water reabsorption along the nephron -- Regulation of body fluid osmolality: regulation of water balance -- Regulation of extracellular fluid volume and NaCI balance -- Regulation of potassium balance -- Regulation of acid-base balance -- Regulation of calcium and phosphate homeostasis -- Physiology of diuretic action -- App. A: Integrative case studies -- App. B: Normal laboratory values -- App. C: Nephron function -- App. D: Answers to self-study problems -- App. E: Answers to integrative case studies -- App. F: Review examination.
  • This book provides a comprehensive overview of the biological basis of renal tumors in childhood and the clinical approaches to their treatment. Recent advances in our understanding of the molecular genetics of Wilms and other renal tumors are placed in their clinical context, including the differing treatment approaches of immediate surgery or pre-operative chemotherapy. The challenges in applying this knowledge to improve risk stratification and to incorporate biologically targeted agents into front-line therapy are discussed. In addition, the current state of thinking of the two major clinical trial groups in these diseases is presented. All of the authors are experts from Europe and North America, and the book has been written specifically as an easy reference for the practising clinician and the research scientist. It lays the basis for understanding the future direction of clinical and translational research to improve outcomes in patients with childhood renal tumors and will prove indispensable for those treating or researching into these diseases.
  • This book describes the recent advances in the understanding of the development and management of renal vascular disease (RVD). Current perspectives regarding the epidemiology of atherosclerotic RVD, its clinical manifestations, and the interaction with injury pathways related to the kidney have evolved considerably, and the widespread introduction of non-invasive methods for identification of RVD using ultrasound, CT, and MR imaging has allowed more facile identification of these diseases than ever before. Renal Vascular Disease provides an accessible, up-to-date summary of the pathophysiology and management of RVD. The clinical paradigms that are emerging in the field, both in regards to RVD and its role in chronic kidney disease (CKD), cardiovascular risk, and the cardiorenal syndromes are discussed in this comprehensive text, making it an essential resource for clinicians and investigators who tackle the challenges of RVD.
  • Systemic versus local renin angiotensin systems: An overview / W.C. DeMello and R.N. Re -- Clinical import of the local renin angiotensin aldosterone systems / E.D. Frohlich -- Renin, prorenin, and the (pro)renin receptor / G. Nguyen and A. Contrepas -- Local renin angiotensin systems in the cardiovascular system / R.N. Re -- Renin-angiotensin-aldosterone system and pathobiology of hypertension / P. Paradis and E.L. Schiffrin -- AT{subscript]1 receptors, angiotensin receptor blockade, and clinical hypertensive disease / R.M. Carey -- Structural and electrophysiological remodeling of the failing heart / W.C. DeMello -- Inhibiting the renin angiotensin aldosterone system in patients with heart failure and myocardial infarction / M.A. Pfeffer -- Left ventricular hypertrophy and treatment with renin angiotensin system inhibition / E.D. Frohlich and J. Díez -- Angiotensin-(1-7), angiotensin-converting enzyme 2, and new components of the renin angiotensin system / A.J. Trask ... [et al.] -- Kinin receptors and ACE inhibitors: An interrelationship / E.G. Erdös, F. Tan and R.A. Skidgel -- Kinins and cardiovascular disease / O.A. Carretero, X.-P. Yang and N.-E. Rhaleb -- CMS and type 2 diabetes mellitus: Bound together by the renin angiotensin aldosterone system / D. Gupta ... [et al.] -- Renin angiotensin aldosterone system and cardiovascular disease / S. Bernard ... [et al.] -- Renin angiotensin system and atherosclerosis / C. Hu and J.L. Mehta -- Renin angiotensin system and aging / L.F. Ferder.

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