Lane Medical Library

TP53 mutations in human cancers : selection versus mutagenesis / Magali Olivier, Audrey Petitjean, Claude Caron de Fromentel, and Pierre Hainaut -- Lessons on p53 from mouse models / Dadi Jiang and Laura D. Attardi -- TP63, TP73 : the guardian's elder brothers / Stephanie Courtois, Pierre Hainaut and Claude Caron de Fromentel -- The regulation of p53 protein function by phosphorylation / Nicola J. Maclaine and Theodore Hupp -- The p53-Mdm2 loop : a critical juncture of stress response / Yaara Levav-Cohen, Zehavit Goldberg, Osnat Alsheich Bartok, Valentina Zuckerman, Sue Haupt and Ygal Haupt -- Cooperation between MDM2 and MDMX in the regulation of p53 / Jeremy Blaydes -- Regulation and function of the original p53-inducible p21 gene / Jennifer A. Fraser -- p53 localization / Carl G. Maki -- Modes of p53 interactions with DNA in the chromatin context / Vladana Vukojevic, Tatiana Yakovleva, and Georgy Bakalkin -- p53's dilemma in transcription : analysis by microarrays / Karuppiah Kannan, Gideon Rechavi and David Givol -- Tumor viruses and p53 / Nobuo Horikoshi -- p53 and immunity / Vikram Narayan, Sarah E. Meek and Kathryn L. Ball.

The peculiarities of infant respiratory physiology / Hammer, J., Eber, E. -- Tidal breathing measurements / Lodrup Carlsen, K.C., Carlsen, K.-H. -- Respiratory mechanics / Davis, S.D., Gappa, M., Rosenfeld, M. -- Forced expiratory flow-volume measurements / Modl, M., Eber, E. -- Infant whole-body plethysmography / Gappa, M., Heulskamp, G. -- Measurement of functional residual capacity and ventilation inhomogeneity by gas dilution techniques / Gustafsson, P.M., Ljungberg, H. -- Techniques for the measurement of lung function in toddlers and preschool children / Hall, G.L., Brookes, I.M. -- Applications and future directions of infant pulmonary function testing / Stocks, J., Lum, S. -- Spirometry: volume-time and flow-volume curves / Eber, E., Zach, M.S. --Plethysmography and gas dilution techniques / Marchal, F., Schweitzer, C. -- Reference equations for ventilatory function measurements in children from 6 to 16 years / Merkus, P.J.F.M. -- Measurement of bronchial responsiveness in children / Barben, J., Riedler, J. -- Measurements of respiratory muscle function in children / Fauroux, B., Lofaso, F. -- Measurements of thoraco-abdominal asynchrony and work of breathing in children / Newth, C.J.L., Hammer, J. -- Lung diffusion capacity / de Jongste, J.C., Merkus, P.J.F.M., Stam, H. -- Measurement of exhaled nitric oxide / Kharitonov, S.A. -- Measurement of nasal nitric oxide / Corbelli, R., Hammer, J. -- Exhaled breath condensate and other markers in exhaled air / Moeller, A., Kielbasa, B. --Childhood asthma and wheezing disorders / Basek, P., Straub, D., Wildhaber, J.H. -- Cystic fibrosis / Ratjen, F. -- Lung transplantation in pediatric patients / Tablizo, M.A., Woo, M.S. -- Neuromuscular disorders / Mellies, U., Dohna-Schwake, C. -- Paediatric oncology and bone marrow transplantation / Cerveri, I. ... [et al.] -- Long-term sequelae of neonatal lung disease / Trachsel, D., Coates, A.L. -- Pulmonary function testing in the neonatal and paediatric intensive care unit / Hammer, J., Newth, C.J.L.

Section 1. Pain and neurology -- Section 2. The neurobiology of pain -- Peripheral signaling of pain -- Spinal cord processing -- Supraspinal processing -- Endogenous pain modulation -- Section 3. The pathophysiology of pain -- Section 4. Pain assessment -- Neurophysiological examinations in neuropathic pain -- Section 5. Pain conditions in neurology: peripheral neuropathies -- Pain after nerve injury -- Facial pain -- Polyneuropathies and pain -- Section 6. Pain conditions in neurology: central neuropathic pain -- Section 7. Other pain conditions of neurological interest -- Section 8. Treatment of neuropathic pain -- Subject index.

Pain management in interventional radiology : an introduction / Jason R. Bauer and Charles E. Ray, Jr. -- Clinical evaluation of low-back pain / Anthony P. Dwyer, Curt Freudenberger, and Vikas V. Patel -- Local anesthetics / Jan Namyslowski -- Functional lumbar spine anatomy : a review / Anthony P. Dwyer ... [et al.] -- Percutaneous vertebroplasty / Mitchell T. Smith and Charles E. Ray, Jr. -- Kyphoplasty / Frances D. Faro, Anthony P. Dwyer, and Vikas V. Patel -- Epidural steroid injections / Brian D. Petersen, Kirkland W. Davis, and James Choi -- Selective nerve root blocks / Brian Petersen, Kirkland W. Davis, and James Choi -- Discography / Charles E. Ray, Jr. and Leo J. Rothbarth -- Facet (zygapophyseal) joint injections / Nick Stence -- Articular interventions in pain management : a general approach / Blaze Cook -- Percutaneous management of visceral pain / Frank Morello -- Embolization of painful neoplasms / Jennifer R. Huddleston and Stephen P. Johnson -- Image-guided ablation of painful osteolyses / David T. Wang and Charles E. Ray, Jr. -- Chronic pelvic pain in women / Derek L. West -- Sedation and analgesia medications / George Behrens, Hector Ferral, and Nilesh H. Patel -- Guidelines for sedation administered by nonanesthesiologists / Iftikhar Ahmad -- Pediatric sedation for radiological imaging studies and interventions / Keira P. Mason -- Nontraditional pain management in interventional radiology / Salomao Faintuch ... [et al.] -- Postprocedural pain control / Stan Zipser.

Mechanistic dissection of pain: from DNA to animal models / Z. David Luo -- Assessment of acute thermal nociception in laboratory Animals / Jeffrey W. Allen and Tony L. Yaksh -- Tissue injury models of persistent nociception in rats / Jeffrey W. Allen and Tony L. Yaksh -- Segmental spinal nerve ligation model of neuropathic pain / Jin Mo Chung, Hee Kee Kim, and Kyungsoon Chung -- Partial sciatic nerve transection / Thies Lindenlaub and Claudia Sommer -- Modeling diabetic sensory neuropathy in rats / Nigel A. Calcutt -- Sciatic inflammatory neuropathy in the rat: surgical procedures, induction of inflammation, and behavioral testing / Erin D. Milligan, Steven F. Marier, and Linda R. Watkins -- A rat pain model of vincristine-induced neuropathy / Emiliano S. Higuera and Z. David Luo -- Loop dialysis catheter: a technology for chronic spinal dialysis in a freely moving rat / Martin Marsala -- Intrathecal catheterization and drug delivery in the rat / Shelle A. Malkmus and Tony L. Yaksh --Trigeminal neuronal recording in animal models of orofacial pain / Koichi Iwata, Yuji Masuda, and Ke Ren -- In vivo electrophysiology of dorsal-horn neurons / Louise C. Stanfa and Anthony H. Dickenson -- Single fiber recording: in vivo and in vitro preparations / Maria Schäfers and David Cain -- Anatomical identification of neurons responsive to nociceptive stimuli / Luc Jasmin and Peter T. Ohara -- Isolation and culture of sensory neurons from the dorsal-root ganglia of embryonic or adult rats / Thomas H. Burkey, Cynthia M. Hingtgen, and Michael R. Vasko -- Primary cultures of neonatal rat spinal cord / Virginia S. Seybold and Lia G. Abrahams -- Single-cell laser capture microdissection and RNA amplification -- Fredrik Kamme ... [et al.] -- Semi-quantitative real-time PCR for pain research / Hong Qing Guo and Sandra R. Chaplan -- Functional genomic analysis in pain research using hybridization arrays / Stephen J. Walker ... [et al.] -- Generation of transgenic mice / Guoping Feng, Jing Lu, and Jimmy Gross -- Knockout mouse models in pain research / Andrée Dierich and Brigitte L. Kieffer.

Introduction --Measuring pain intensity --Measuring pain quality --Measuring pain location --Measuring pain behavior --Measuring pain interference --Measuring sleep quality --Measuring depression --Measuring general physical functioning --Measuring alcohol and drug use --Measuring global improvement and satisfaction with pain care --References.

Introduction to Diabetic Neuropathies -- Classification and Clinical Features -- Diagnosis and Staging -- Management of Neuropathic Pain.

Great plagues of the past and remaining questions / Cheston B. Cunha and Burke A. Cunha -- Identification and interpretation of historical cemeteries linked to epidemics / Dominique Castex -- Archaeological proof of an abrupt mortality crisis : simultaneous deposit of cadavers, simultaneous deaths? / Henri Duday -- Molecular detection of past pathogens / Michel Drancourt and Didier Raoult -- Histologic detection of past pathogens / Hubert Lepidi -- Palaeomicrobiology of tuberculosis / Helen D. Donoghue -- Past leprae / Andreas G. Nerlich and Albert R. Zink -- Archaeology of human pathogens : palaeopathological appraisal of palaeoepidemiology / Olivier Dutour -- Past plague / Michel Drancourt and Didier Raoult -- Typhoid fever epidemic in ancient Athens / Manolis J. Papagrigorakis, Christos Yapijakis and Philippos N. Synodinos -- Dental pulp as a tool for the retrospective diagnosis of infectious diseases / Vu Dang La ... [et al.] -- History of influenza pandemics / Bruno Lina -- Human lice : Pediculus and Pthirus / Kosta Y. Mumcuoglu.

Paleoradiology : history and new developments / Rethy K. Chhem -- Paleoradiologic techniques / George Saab, Rethy K. Chhem, and Richard N. Bohay -- The taphonomic process, biological variation, and x-ray studies / Don R. Brothwell -- Diagnostic paleoradiology for paleopathologists / Rethy K. Chhem, George Saab, and Don R. Brothwell -- Paleoradiology in the service of zoopaleopathology / Don R. Brothwell -- Normal variations in fossils and recent human groups / Don R. Brothwell -- Concluding comments / Rethy K. Chhem and Don R. Brothwell.

Global Palliative Care Issues / Marissa Slaven -- Palliative Care Communication Issues / Joshua Hauser -- Nutritional Palliative Care Issues / Clay M. Anderson -- Psychiatric Palliative Care Issues / Jane E. Loitman and Teresa Deshields -- Cardiac Palliative Care Issues / David Wensel and Drew A. Rosielle -- Pulmonary Palliative Care Issues / Karin B. Porter-Williamson -- GI Palliative Care Issues / Eric Roeland and Gary Buckholz -- Palliative Pain Issues / Miles J. Belgrade -- Palliative Wound and Skin Issues / Cynthia A. Worley -- Issues in the Last Hours / Jane E. Loitman and Christian T. Sinclair.

v. 1. Chapters 1-25 -- v. 2. Chapters 26-54.

Anatomy of the pancreas / Mary Kay Washington -- -- Pathology of the exocrine pancreas / Ralph H. Hruban, Syed Z. Ali -- Molecular genetic alterations in cancer-associated genes / Michiel S. van der Heijden, Scott E. Kern -- Molecular signal pathways in pancreatic cancer / Nabeel Bardeesy -- Pancreatic development / John W. Lin, Steven D. Leach -- Mouse-models of exocrine pancreatic cancer / Eric P. Sandgren -- Epidemiology / Donghui Li, Li Jiao -- Hereditary pancreatitis and its link to pancreatic cancer / Saima Sharif ... [et al.] -- Familial pancreatic cancer / Ralph Hruban ... [et al.] -- Prevention / Marsha L. Frazier -- -- Pancreatic cancer: clinical presentation / Vincent J. Picozzi -- Radiographic imaging: CT/MR/PET / Eric Tamm ... [et al.] -- Endoscopic staging: EUS, ERCP / Richard A. Erickson -- Laparoscopic staging / Olga N. Tucker, Kevin C. Conlon -- Fine-needle aspiration biopsy of the pancreas: indications and interpretations / Gregg A. StaerkelClinical trial design and methodology / Jason A. Konner, Eileen M. O'Reilly -- Supportive care: symptom management / Suresh K. Reddy, Ahmed Elsayem, Rudranath Talukdar -- Supportive care: cachexia and anorexia syndrome / Michael J. Tisdale -- -- Target discovery: genomics/proteomics / Christine A. Iacobuzio-Donahue -- Gene therapy and virotherapy of pancreatic cancer / Masato Yamamoto, David T. Curiel -- Antiangiogenic therapy for pancreatic cancer / Chandrajit P. Raut, Lee M. Ellis -- Vaccines / Daniel A. Laheru, Elizabeth M. Jaffe --Serologic diagnosis of pancreatic cancer / Matthew H. Katz, Abdool R. Moossa, Michael Bouvet -- The Molecular diagnosis of pancreatic cancer / Michael G. Goggins -- -- Pancreaticoduodenectomy / Tina W. F. Yen ... [et al.] -- The Role of total pancreatectomy in the treatment of pancreatic cancer / John D. Christein, Michael B. Farnell -- Distal pancreatectomy / Scott F. Gallagher, Emmanuel E. Zervos, Michel M. Murr -- Pylorus preservation versus standard pancreaticoduodenectomy / Taylor S. Riall, Charles J. Yeo -- Pancreaticoduodenectomy with en bloc vascular resection and reconstruction for localized carcinoma of the pancreas / Charles R. Scoggins, Jeffrey E. Lee, Douglas B. Evans -- Reducing the risk of pancreaticoduodenectomy / Laura A. Lambert, John D. Birkmeyer -- Interventional radiology in the management of postoperative complications / Michael J. Wallace, Stephen McRaeThe Principles of chemoradiation in localized pancreatic cancer / Christopher H. Crane -- Adjuvant and neoadjuvant therapies for resectable pancreatic cancer / Robert A. Wolff -- Postoperative adjuvant therapy and the rationale for the U.S. intergroup trial / Young Kwok, Michael C. Garofalo, William F. Regine -- Intraoperative electron beam irradiation in pancreatic cancer / Christopher G. Willett, Peter J. Biggs, Carlos Fernández-del Castillo -- -- Systemic therapy and chemo-radiotherapy / Ross A. Abrams -- Endoscopic palliation of pancreatic cancer / David Whitaker, Benedict M. Deveraux -- Surgical palliation of pancreatic cancer / Michael L. Kendrick ... [et al.] -- -- Advanced metastatic disease / Marcel Rozencweig, Daniel D. Von HoffTumors of the endocrine system / David S. Klimstra -- Sporadic gastrinoma / Chandu Vemuri, Gerard M. Doherty -- Rare functioning tumors: VIPoma, glucagonoma, somatostatinoma / Geoffrey B. Thompson -- Pancreatic endocrine neoplasms in multiple endocrine neoplasia type 1 / Maria A. Kouvaraki ... {et al.] -- The von Hippel-Landau syndrome / Eric Jonasch -- Non-functioning pancreatic endocrine tumors / Carmen C. Solorzano, Jeffrey E. Lee -- Management of metastatic islet cell carcinoma / James C. Yao, Maria A. Kouvaraki, Sanjay Gupta -- -- Pathology of periampullary tumors / Mari Mino, Gregory Y. Lauwers -- Clinical management of ampullary tumors / Rebekah R. White ... [et al.] -- -- Pathological classification of cystic neoplasms of the pancreas / N. Volkan Adsay -- Imaging of cystic pancreatic tumors / Chusilp Charnsangavej, Eric P. Tamm -- Surgical treatment of cystic neoplasms / Carlos Fernández-del Castillo -- -- Tumors of the distal common bile duct / Jorge Abores-Saavedra.

Introduction to Pancreatic Cytopathology -- Pancreatic Cytopathology: A Pragmatic Approach -- Pancreatic Ductal Adenocarcinoma and Its Variants -- Ancillary Testing for the Diagnosis of Pancreatic Ductal Adenocarcinoma -- Acinar Cell Carcinoma -- Pancreatoblastoma -- Solid-Pseudopapillary Neoplasm -- Pancreatic Endocrine Tumors -- Cystic Muscus-Producing Neoplasia: Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms -- Other Cystic Lesions of the Pancreas -- Inflammatory Disease of the Pancreas -- Secondary Malignancies of the Pancreas.

Part 1. Potential Trials in Acute Pancreatitis -- Acute Pancreatitis in Intensive Care / John Kinsella, Barry Clements, Euan Dickson, Thierry Dugernier and Martin Hughes -- Antibiotic Prophylaxis in Acute Severe Pancreatitis: Should We Have a Further Study? / Jens Werner, Kevin C. P. Conlon, Hjalmar C. van Santvoort, Caroline S. Verbeke and Sakhawat H. Rahman -- Designing an Optimal Study for the Management of Infected Pancreatic Necrosis / Marc G. H. Besselink, Hjalmar C. van Santvoort, Ross Carter, Richard M. Charnley and Damian J. Mole, et al. -- Nutrition in Acute Pancreatitis / Hemant M. Kocher, Christos Dervenis, Attila Oláh, William R. Murray and Barry Clements, et al. -- An Optimal Randomized Study for Pain Control in Acute Pancreatitis / Åke Andrén-Sandberg, Julia V. Mayerle, Ajith K. Siriwardena, David P. Berry and Gareth R. Kirk, et al. -- Part 2. Potential Trials in chronic Pancreatitis -- Endoscopic Versus Surgical Drainage for Chronic Pancreatitis / Stephen P. Pereira, Shivi S. Siva and Colin D. Johnson -- Duodenum-Preserving Pancreatic Resection with Pancreatic Duct Drainage: What Is the Role of Supraduodenal Biliary Drainage? / Emre F. Yekebas, Christos Dervenis, Richard M. Charnley, Bettina M. Rau and Jens Werner, et al. -- Part 3. Potential Trials in Pancreatic Cancer -- Pain Management and Nutritional Support in Nonresectable Pancreatic Cancer / David P. Berry, Richard M. Charnley, Christos Dervenis, Gareth R. Kirk and Francis Regan, et al. -- Endoscopic Therapy in the Palliation of Nonresectable Pancreatic Cancer / Attila Oláh, William R. Murray, Colin J. McKay, Åke Andrén-Sandberg and Sakhawat H. Rahman, et al. -- Pancreatic Endocrine Tumors / Damian J. Mole, Caroline S. Verbeke and Nicholas S. Reed -- The Role of the Systemic Inflammatory Response in Predicting Outcome in Patients with Pancreatic Cancer / Donald C. McMillan -- Part 4. Topic reviews -- Botulinum Toxin and the Sphincter of Oddi / William R. Murray -- The European Study Group for Pancreatic Cancer (ESPAC) Trials / Paula Ghaneh, Khaled Dajani, Michael G. T. Raraty, Robert Suttton and John P. Neoptolemos.

Epidemiology and pathophysiology of acute pancreatitis / Anil B. Nagar and Fred S. Gorelick -- Diagnosis and risk stratification of acute pancreatitis / Frank Burton -- Gallstone pancreatitis / Matthias Kraft and Markus M. Lerch -- Other causes of acute pancreatitis / Charles D. Ulrich -- Treatment of mild acute pancreatitis and prevention of post-ERCP pancreatitis / Michael Morelli and Lehel Somogyi -- Treatment of severe acute pancreatitis / Peter Draganov -- Pancreatic necrosis and infections in patients with acute pancreatitis / Michael L. Kendrick and Michael G. Sarr --Pancreatic fluid collections and pseudocysts in patients with acute pancreatitis / Michael F. Byrne and John Baillie -- Epidemiology of chronic pancreatitis / Albert B. Lowenfels and Patrick Maisonneuve -- Risk, etiology, and pathophysiology of chronic pancreatitis / David C. Whitcomb -- Natural history of chronic pancreatitis / Supot Pongprasobchai and Jonathan E. Clain -- Diagnosis of chronic pancreatitis / Chris E. Forsmark --Treatment of chronic pancreatitis pain: overview and medical management / Phillip P. Toskes -- Endoscopic approach to chronic pancreatitis / Lee McHenry, Glen Lehman, and Stuart Sherman -- Surgery for chronic pancreatitis / Martin D. Smith, Elias Degiannis, and Selwyn M. Vickers --Treatment of exocrine pancreatic insufficiency / Supot Pongprasobchai and Eugene P. DiMagno -- Complications of chronic pancreatitis / John Petersen and Chris E. Forsmark.

Influenza pandemics are unpredictable but recurring events that can have severe consequences on societies worldwide. This revised WHO guidance publication on pandemic influenza preparedness and response acknowledges that pandemic preparedness is centered around health sectors planning but must also be broader. WHO therefore advocates a "whole-of-society" approach to sustainable and ethical pandemic preparedness while focusing in more detail on the role of the health sector. The roles of WHO and national governments are outlined to create a better understanding of how health and non-health sectors, both public and private, all contribute to pandemic preparedness.--Publisher's description.

Pt. 1. Introductory background -- pt. 2. Paradigms in the arts and social sciences -- pt. 3. General-integrative paradigms in psychology -- pt. 4. Particular-specific paradigms in psychology -- pt. 5. Operational paradigms in psychology -- pt. 6. Conclusion.

Parallel and evolutionary approaches to computational biology /Nouhad Rizk --Parallel Monte Carlo simulation of HIV molecular evolution in response to immune surveillance /Jack da Silva --Differential evolutionary algorithms for in vivo dynamic analysis of glycolysis and pentose phosphate pathway in Escherichia coli /Andrei Doncescu --Compute-intensive simulations for cellular models /Kevin Burrage --Parallel computation in simulating diffusion and deformation in human brain /Jun Zhang --Computational molecular biology /Azzedine Boukerche --Special-purpose computing for biological sequence analysis /Bertil Schmidt --Multiple sequence alignment in parallel on a cluster of workstations /Amitava Datta --Searching sequence databases using high performance BLASTs /Xue Wu --Parallel implementations of local sequence alignment: hardware and software /Vipin Chaudhary --Parallel computing in the analysis of gene expression relationships /Robert Martino --Parallel algorithms for solving the fragment assembly problem in DNA strands /Enrique Alba --A cooperative genetic algorithm for knowledge discovery in microarray experiments /Mohammad Khabzaoui --Parallel and distributed computation of large phylogenetic trees /Alexandros P. Stamatakis --Phylogenetic parameter estimation on COWs /Ekkehard Petzold --High-performance phylogeny reconstruction under maximum parsimony /Tiffani Williams --Protein folding with the parallel replica exchange molecular dynamics method /Ruhong Zhou --High performance alignment methods for protein threading /R. Andonov --Parallel evolutionary computations in discerning protein structures /Richard O. Day --A brief Overview of Grid activities for bioinformatics and health applications /Ali Al Mazari --Parallel algorithms for bioinformatics /Shahid H. Bokhari --Cluster and grid infrastructure for computational chemistry and biochemistry /Kim K. Baldridge --Distributed workflows in bioinformatics /Arun Krishnan --Molecular structure determination on a computational and data grid /Russ Miller --GIPSY : a problem solving environment for bioinformatics applications /Rajendra R. Joshi --TaskSpaces : a software framework for parallel bioinformatics on computational grids /Hans De Sterck --The organic grid : self-organizing computation on desktop grids /Arjav J. Chakrvarti --FPGA Computing in modern bioinformatics /H. Simmler --Virtual microscopy : distributed image storage, retrieval, analysis, and visualization /T. Pan

Mating types in paramecium -- General description of the protista and of paramecium -- Methods of studying genetic processes in organisms of the paramecium Aurelia species group -- The determination of mating types in paramecium -- Symbionts and mitochondria of paramecium -- Determination of i-antigens -- Micronuclei and macronuclei -- Ribosomal RNA and DNA -- Cortical morphogenesis -- Behavior -- Epigenetics.

History -- Clinical findings, treatment and prognosis -- Pathogenesis -- Brain (cerebrum) -- Brain (cerebellum and brainstem) -- Spinal cord -- Cranial nerves -- Dorsal root ganglia and peripheral nerves -- Neuromuscular junction and muscle -- Systemic syndromes (with neurologic implications) -- Nuclear/nucleolar antibodies -- Cytoplasmic antibodies -- Synaptic/channel antibodies -- Anti-retinal/optic nerve antibodies -- Thoracic cancers -- Breast/gynecologic/testicular cancer -- Hematologic cancers/miscellaneous solid tumors.

Sequencing strategies for parasite genomes / Daniella Bartholomeu and Najib M. El-Sayed -- Annotation of parasite genomes / Matthew Berriman and Midori Harris -- Parasite genome databases and web-based resources / Christiane Hertz-Fowler and Neil Hall -- Expressed sequence tags: medium-throughput protocols / Claire Whitton ... [et al.] -- Expressed sequence tags: analysis and annotation / John Parkinson and Mark Blaxter -- Positive selection scanning of parasite DNA sequences / Winston A. Hide and Raphael D. Isokpehi -- RACE and RAGE cloning in parasitic microbial eukaryotes / Bryony A. P. Williams and Robert P. Hirt -- Amplified (restriction) fragment length polymorphism (AFLP) analysis / Daniel K. Masiga and C. Michael R. Turner -- Minisatellites and MVR-PCR for the individual identification of parasite isolates / Annette MacLeod -- Analysis of differentially expressed parasite genes and proteins using transcriptomics and proteomics / Daniel C. Gare --Gene expression studies using self-fabricated parasite cDNA microarrays / Karl F. Hoffmann and Jennifer M. Fitzpatrick -- DNA content analysis on microarrays / Upinder Singh, Preetam H. Shah, and Ryan C. MacFarlane -- Typing single-nucleotide polymorphisms in Toxoplasma gondii by allele-specific primer extension and microarray detection / Chunlei Su ... [et al.] -- Transfection of the human malaria parasite plasmodium falciparum / Brendan S. Crabb ... [et al.] -- A PCR-based method for gene deletion and protein tagging in Trypanosoma brucei / George K. Arhin ... [et al.] -- Analysis of gene function in Trypanosoma brucei using RNA interference / Appolinaire Djikeng ... [et al.] -- In vitro shuttle mutagenesis using engineered mariner transposons / Kelly A. Robinson, Sophie Goyard, and Stephen M. Beverley -- Random mutagenesis strategies for construction of large and diverse clone libraries of mutated DNA fragments / Sudsanguan Chusacultanachai and Yongyuth Yuthavong -- Separation, digestion, and cloning of intact parasite chromosomes embedded in agarose / Vanessa Leech, Michael A. Quail, and Sara E. Melville -- Chromosome fragmentation in Leishmania / Pascal Dubessay ... [et al.] --FISH mapping for helminth genomes / Hirohisa Hirai and Yuriko Hirai -- Fiber-FISH: fluorescence in situ hybridization on stretched DNA / Klaus Ersfeld -- Yeast two-hybrid assay for studying protein-protein interactions / Ahmed Osman -- From genomes to vaccines for leishmaniasis / Carmel B. Stober.

"Parasitoids are parasitic insects that kill their insect hosts in immature pre-reproductive stages. Parasitoids are employed in biological control programs worldwide to kill insect pests and are environmentally safe and benign alternatives to chemical pesticides. As resistance to chemical pesticides continues to escalate in many pest populations, attention is now refocusing on biologically based strategies to control pest species in agriculture and forestry as well as insect vector populations that transmit human and animal diseases. Parasitoids are an economically critical element in this equation and in integrated pest management. Viruses have evolved intimate associations with parasitoids, and this book features a large section on symbiotic viruses that are integrated into the wasp chromosomal DNA (polydnaviruses). A separate section on parasitoid venoms, which are of interest to the pharmaceutical and medical communities as well as insect-oriented biologists, is also featured"--Back cover.

Depression / William J. Burke, Steven P. Wengel, and Daryl Bohac -- Anxiety / Hubert H. Fernandez and Tanya Simuni -- Obsessionality / Marie-Andrée Bruneau -- Dementia / Patricia Kavanagh and Karen Marder -- Psychosis / Eric S. Molho and Stewart A. Factor -- Postsurgical behavioral changes / Laurie M. Rilling, John A. Lucas, and Ryan J. Uitti -- Dysphagia / Norman A. Leopold -- Gastric dysfunction / Tanya Gurevich, Amos D. Korczyn, and Nir Giladi -- Intestinal dysfunction / Ronald F. Pfeiffer --Impaired sexual function / Cheryl Waters and Janice Smolowitz -- Urological dysfunction / Carlos Singer -- Cardiovascular autonomic dysfunction / David S. Goldstein -- Thermoregulatory dysfunction / Mark S. LeDoux -- Respiratory dysfunction / Holly A. Shill -- Insomnia / Maria L. Moro-de-Casillas and David E. Riley -- Rapid eye movement sleep behavior disorder / Suzanne Stevens and Cynthia Comella -- Excessive daytime sleepiness / David Hardesty, Daryl Victor, and Steven J. Frucht --Sleep apnea / Cheryl M. Carlucci and Robert A. Hauser -- Visual dysfunction / Robert L. Rodnitzky -- Primary visual and visuocognitive deficits / Ivan Bodis-Wollner and Andrea Antal -- Olfactory dysfunction / Sarah Furtado and Zbigniew K. Wszolek -- Pain syndromes and disorders of sensation / Blair Ford and Ronald F. Pfeiffer -- Oculomotor dysfunction / Parashkev Nachev and Christopher Kennard -- Fatigue / Carol Ewing Garber and Joseph H. Friedman.

An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly Bérubé -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody --Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderón-Garcidueñas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schülte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm.

Pasteurella multocida: Diseases and Pathogenesis /I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler --Pathogenomics of Pasteurella multocida /J. D. Boyce, T. Seemann, B. Adler and M. Harper --The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide /Marina Harper, John D. Boyce and Ben Adler --Pasteurella multocida and Immune Cells /Katharina F. Kubatzky --Molecular Biology of Pasteurella multocida Toxin /Joachim H. C. Orth and Klaus Aktories --Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects /Brenda A. Wilson and Mengfei Ho --Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin /Yasuhiko Horiguchi --The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer /Alistair Lax.

Pathophysiology of anterior knee pain -- Pathophysiology of lateral patellar dislocation -- Natural history of patellofemoral dislocations -- Clinical presentation of patellofemoral disorders -- Clinical examination of the patellofemoral patient -- Standard X-ray examination: patellofemoral disorders -- Patellar height: which index? -- Stress radiographs in the diagnosis of patellofemoral instability -- Computed tomography and arthro-CT scan in patellofemoral disorders -- MRI analysis of patella instability factors -- MRI of the patellofemoral articular cartilage -- Patellofemoral pain syndrome: the value of pinhole and SPECT scintigraphic imaging and quantitative measurements of bone mineral equivalent density with quantitative computed tomography -- Gait analysis in patients with patellofemoral disorders -- Iatrogenic anterior knee pain with special emphasis on the clinical radiographical, histological, ultrastructural and biochemical aspects after anterior cruciate ligament reconstruction using ipsilateral autografts -- Non-operative treatment of patellofemoral pain: role of physical therapy -- Lateral release of the lateral patellofemoral retinaculum: literature review for select patellofemoral disorders -- Medial side patellofemoral anatomy -- Arthroscopic medial reefing in acute patellar dislocation -- Medial reefing in chronic potential patellar instability -- Medial patellofemoral ligament reconstruction -- MPFL reconstruction: the adductor sling approach -- Importance and radiographic identification of the femoral insertion in medial patellofemoral ligament reconstruction -- MPTL (medial patellotibial ligament) reconstruction -- Distal realignment: medialization of tibial tuberosity: the Elmslie-Trillat technique -- Bony surgery distal realignment surgery -- Trochlear lengthening osteotomy with or without elevation of the lateral trochlear facet -- Proximal open trochleoplasty (grooveplasty) -- Deepening trochoplasty for patellar instability -- Arthroscopic deepening trochleoplasty for patella instability -- The role of limb rotational osteotomy -- Long-term results after autologous chondrocyte implantation in cartilage lesions of the patellofemoral joint -- Novel nano-composite multilayered biomaterial for the treatment of patellofemoral cartilage lesions -- Isolated patellofemoral osteoarthritis: natural history and clinical presentation -- The nonoperative treatment of patellofemoral arthritis -- Current concepts regarding tibial tubercle osteotomy -- Isolated patellofemoral osteoarthritis: prosthetic indications -- Post-operative management of surgeries aimed at correcting patellofemoral instability: results of an international surgeon survey -- Errors and complications in patellofemoral surgery -- Trochleoplasty for symptomatic trochlear dysplasia in the skeletally immature patient with review of fetal anatomy -- Patellofemoral disorders in the skeletally immature patients.

Bacterial toxins as immunomodulators / David S. Donaldson and Neil A. Williams -- Innate immune evasion by staphylococci / Karin Ellen Veldkamp and Jos A.G. van Strijp -- Bacterial complement escape / Ilse Jongerius, Sanjay Ram, and Suzan Rooijakkers -- Modulation of innate immune signalling pathways by viral proteins / Orla Mulhern, Barry Harrington, and Andrew G. Bowie -- Viral TNF inhibitors as potential therapeutics / Masmudur M. Rahman, Alexandra R. Lucas, and Grant McFadden -- Lipoxins as an immune-escape mechanism / Fabiana S. Machado and Julio Aliberti -- Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES62 / William Harnett and Margaret M. Harnett -- Helminth-derived immunomodulatory molecules / Poom Adisakwattana ... [et al.] -- Fungal-derived immune modulating molecules / Tania C. Sorrell and Sharon C.A. Chen -- The immunosuppresive tick salivary protein, Salp15 / Ignacio J. Juncadella and Juan Anguita -- The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics / Alexandra Lucas ... [et al.] -- Helminthic therapy : using worms to treat immune-mediated disease / David E. Elliott and Joel V. Weinstock -- Chemokine binding proteins encoded by pathogens / Antonio Alcami and Margarida Saraiva.

Introduction -- Natural ecology and survival in water of mycobacteria of potential public health significance -- Environmental sources of Mycobacterium avium linked to routes of exposure -- Biology of waterborne pathogenic mycobacteria -- Analytical methods for the detection of waterborne and environmental pathogenic mycobacteria -- The Mycobacterium avium subspecies paratuberculosis problem and its relation to the causation of Crohn disease -- Disseminated infection, cervical adenitis and other MAC infections -- Skin, bone and soft tissue infections -- Pulmonary infection in non-HIV infected individuals -- Disease resulting from contaminated equipment and invasive procedures -- Control, treatment and disinfection of Mycobacterium avium complex in drinking water -- Approaches to risk management in priority setting -- References -- Index.

'Each book in the ... series offers a visually-integrated approach to review and is packaged with a CD-ROM, which serves as practice for the USMLE Step 1." -p.vii Preface.

Ch. 1. Enteroviruses -- Ch. 2. Rhinoviruses -- Ch. 3. Influenza viruses -- Ch. 4. Parainfluenza viruses -- Ch. 5. Respiratory syncytial virus (RSV) -- Ch. 6. Herpesviruses: general principles -- Ch. 7. Herpes simplex virus (HSV) types 1 and 2 -- Ch. 8. Cytomegalovirus -- Ch. 9. Epstein-Barr virus (EBV) -- Ch. 10. Varicella-Zoster virus (VZV) -- Ch. 11. Herpesvirus type 6 (HHV-6) -- Ch. 12. Kaposi sarcoma-associated herpesvirus (KSHV, HHV-8) -- Ch. 13. Herpesvirus simiae virus (Herpes B) -- Ch. 14. Adenoviruses -- Ch. 15. Retroviruses: general principles -- Ch. 16. Human immunodeficiency viruses -- Ch. 17. Human T cell leukemia/lymphoma viruses (HTLV-1 and -2) -- Ch. 18. Hepatitis viruses -- Ch. 19. Hemorrhagic fever viruses -- Ch. 20. Hantavirus pulmonary syndrome (HPS) -- Ch. 21. Papillomaviruses -- Ch. 22. Papovaviruses -- Ch. 23. Parvoviruses -- Ch. 24. Neurotropic arthropod-transmitted viruses -- Ch. 25. Rabieviruses -- Ch. 26. Poxviruses -- Ch. 27. Mumps -- Ch. 28. Rubellavirus -- Ch. 29. Rubeola (measles) -- Ch. 30. Transmissible spongiform encephalopathy -- Ch. 31. Lymphocytic choriomeningitis virus (LCMV) -- Ch. 32. Enteric viral disease.

Epidemiology of Mesothelioma -- Molecular Biology -- Serosal Anatomy and Anatomic Distribution of Mesothelioma -- Clinical Aspects of Mesothelioma -- Management of Malignant Serosal Effusions -- Pathologic Diagnosis and Classification of Mesothelioma -- Macroscopic Features of Mesotheliomas -- Classification and Histologic Features of Mesotheliomas -- Differential Diagnosis: Mesothelial Proliferations -- Differential Diagnosis: Other Mesothelial Lesions -- Differential Diagnosis: Nonmesothelial Lesions -- Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas -- Differential Diagnosis: Other Nonmesothelial Tumors.

Examination of the placenta -- Macroscopic features of the delivered placenta -- Microscopic survey -- Placental types -- Early development of the human placenta -- Basic structure of the villous trees -- Architecture of normal villous trees -- Characterization of the developmental stages -- Nonvillous parts and trophoblast invasion -- Involution of placental site; retained placenta -- Anatomy and pathology of the placental membranes -- Anatomy and pathology of the umbilical cord -- Placental shape aberrations -- Histopathologic approach to villous alterations -- Classification of villous maldevelopment -- Erythroblastosis fetalis and hydrops fetalis -- Transplacental hemorrhage, cell transfer, trauma -- Fetal storage disorders -- Maternal diseases complicating pregnancy: diabetes, tumors, preeclampsia, lupus anticoagulant -- Infectious diseases -- Abortion, placentas of trisomies, and immunologic considerations of recurrent reproductive failure -- Molar pregnancies -- Trophoblastic neoplasms -- Benign tumors and chorangiosis -- Multiple pregnancies -- Legal considerations -- Glossary -- Normative values and tables.

Appendix 1: Placental weight -- Appendix 2: Medicolegal aspects of placental pathology.Pathology of the placenta: an introduction and overview -- The development and structure of the placenta -- Physiology of the placenta -- Abnormalities of placentation and of placental development -- Macroscopoic abnormalities of the placenta -- Histological abnormalities of the placenta -- The placenta in pregnancies of abnormal duration -- The placenta in maternal disorders -- The placenta in abnormalities and disorders of the fetus -- The placenta in miscarriage -- Infections and inflammatory lesions of the placenta -- The placenta in multiple pregnancy -- Immunopatholgoy of the placenta -- Non-trophoblastic tumours of the placenta -- Gestational trophoblastic disease -- Pathology of the umbilical cord -- Pathology of the membranes -- Correlation of ultrasonic and pathological findings.

The criminalistics of controlled substances / Joseph P. Bono -- Overview of pathology of drug abuse : scene of death and the autopsy / Charles V. Wetli -- Heart disease / Renu Virmani, Allen P. Burke, Andrew Farb -- Vascular effects of substance abuse / Frank D. Kolodgie, Allen P. Burke, Jagat Narula, Florabel G. Mullick, Renu Virmani -- Myocardial alterations in drug abusers / Steven B. Karch -- Valvular heart disease / Michael D. Bell -- Lung disease / Michael D. Bell -- Disorders of the central nervous system / Michael D. Bell -- Toxicogenetics in drug abuse : pharmacogenomics for toxicology / Robert M. White, Steven H.Y. Wong -- Toxicogenetics in drug abuse : heritable channelopathies and myopathies / Kathryn A. Glatter, Jonica Calkins, Sanjay J. Ayirookuzhi.

The cell : structure, function, and molecular biology / Shankar Vallabhajosula, Seham Mustafa -- Pathophysiology and mechanisms of radiopharmaceutical localization / Shankar Vallabhajosula, Azu Owunwanne -- Basis of ¹⁸F-FDG positron emission tomography imaging / Seham Mustafa, Abbas Alavi, Abdelhamid H. Elgazzar -- Inflammation / Abdelhamid H. Elgazzar, Magda Elmonayeri -- Nuclear hematology / Kshitish C. Das -- Musculoskeletal system / Abdelhamid H. Elgazzar, Dia Shehab -- Thyroid gland / Salil D. Sarkar -- Parathyroid gland / Abdelhamid H. Elgazzar -- Adrenal gland / Sleiman Naddaf, Abdelhamid H. Elgazzar -- Basis of renal scintigraphy / Salil D. Sarkar, Pravin C. Singhal -- Basis of tumor imaging 1 : principles of tumor pathology and biology / Ezzeldin M. Ibrahim, Jaudah A. Al-Maghrabi -- Basis of tumor imaging 2 : scintigraphic and pathophysiologic correlation / Suman Jana, Hussein M. Abdel-Dayem -- Respiratory system / Abdelhamid H. Elgazzar, Moussa Khadada -- Basis of cardiac imaging 1: myocardial contractility and assessment of cardiac function / Sherif I. Heiba, Mohammad Zubaid -- Basis of cardiac imaging 2 : myocardial perfusion, metabolism, infarction, and receptor imaging in coronary artery disease and congestive heart failure / Josef Machac -- Digestive system 1 : gastrointestinal tract / Fuad Hassan, Eman Al-Enizi, Abdelhamid H. Elgazzar -- Digestive system 2 : liver and biliary tract / Chun K. Kim, Borys R. Krynyckyi, Josef Machac -- Basis and clinical application of brain imaging / James M. Mountz, Elmer C. San Pedro -- Basis of antibody imaging and therapy / Lionel S. Zuckier -- Lymphoscintigraphy / Arthur Z. Krasnow, Abdelhamid H. Elgazzar, Nafisah Kazem -- Basis of pediatric genitourinary imaging / Abdelhamid H. Elgazzar -- Basis of therapeutic nuclear medicine / Abdelhamid H. Elgazzar, Abdullatif Al-Bader -- Biological effects of ionizing radiation / Abdelhamid H. Elgazzar, Nafisah Kazem -- Glossary.

Basic cardiac structure and function / Vivek Iyer, Elazer R. Edelman, and Leonard S. Lilly -- The cardiac cycle: mechanisms of heart sounds and murmurs / Nicole Martin and Leonard S. Lilly -- Diagnostic imaging and catheterization / Nicole Martin and Patricia Challender Come -- The electrocardiogram / Lilit Garibyan and Leonard S. Lilly -- Atherosclerosis / James L. Young and Peter Libby -- Ischemic heart disease / Haley Naik, Marc S. Sabatine, and Leonard S. Lilly -- Acute coronary syndromes / Haley Naik, Marc S. Sabatine, and Leonard S. Lilly -- Valvular heart disease / Mia M. Edwards, Patrick T. O'Gara, and Leonard S. Lilly -- Heart failure / Ravi Vikram Shah and Michael A. Fifer -- The cardiomyopathies / Marc N. Wein, G. William Dec, and Leonard S. Lilly -- Mechanisms of cardiac arrhythmias / Hillary K. Rolls ... [et al.] -- Clinical aspects of cardiac arrhythmias / Hillary K. Rolls, William G. Stevenson, and Leonard S. Lilly -- Hypertension / Payman Zamani, Gordon H. Williams, and Leonard S. Lilly -- Diseases of the pericardium / Yanerys Ramos and Leonard S. Lilly -- Diseases of the peripheral vasculature / Arash Mostaghimi and Mark A. Creager -- Congenital heart disease / Vijay G. Sankaran and David W. Brown -- Cardiovascular drugs / Martin W. Schoen ... [et al.].

Basic cardiac structure and function / Ken Young Lin ... [et al.] -- The cardiac cycle : mechanisms of heart sounds and murmurs / Henry Jung and Leonard S. Lilly -- Cardiac imaging and catheterization / Henry Jung, Ken Young Lin, and Patricia Challender Come -- The electrocardiogram / Stephen R. Pomedli and Leonard S. Lilly -- Atherosclerosis / Jordan B. Strom and Peter Libby -- Ischemic heart disease / June-Wha Rhee, Marc S. Sabatine, and Leonard S. Lilly -- Acute coronary syndromes / June-Wha Rhee, Marc S. Sabatine, and Leonard S. Lilly -- Valvular heart disease / Christopher A. Miller, Patrick T. O'Gara, and Leonard S. Lilly --Heart failure / Neal Anjan Chatterjee and Michael A. Fifer -- The cardiomyopathies / Christopher T. Lee, G. William Dec, and Leonard S. Lilly -- Mechanisms of cardiac arrhythmias / Ranliang Hu ... [et al.] -- Clinical aspects of cardiac arrhythmias / Ranliang Hu, William G. Stevenson, and Leonard S. Lilly -- Hypertension / Christopher T. Lee, Gordon H. Williams, and Leonard S. Lilly -- Diseases of the pericardium / Yin Ren and Leonard S. Lilly -- Diseases of the peripheral vasculature / Fan Liang and Mark A. Creager -- Congenital heart disease / David D. Berg and David W. Brown -- Cardiovascular drugs / Cyrus K. Yamin ... [et al.].

1. Pulmonary, ob/gyn, ent, hem/onc -- 2. GI, neurology, rheumatology, endocrinology -- 3. CVS, dermatology, GU, general surgery.

I. Pulmonary, ob/gyn, ENT, hem/onc -- II. GI, neurology, rheumatology, endocrinology -- III. CV, dermatology, GU, orthopedics, general surgery, peds.

"But doctor, it takes three tests to find the bottom" -- This better not be serious-I've got a plane to catch -- Whew! the tests are negative, and I've got a plane to catch -- Taking my lumps: biopsy blues -- "Once per lethal disease": coping with chemo -- "How can you know I'm in remission?" -- What's so special about fifty-five? -- Graduation to the bone marrow unit -- "Zap it to me": staring into a Hiroshima-dose of radiation -- Hospital arrest -- My re-birthday -- How much risk is too much? -- Can't I stay another day? -- Darth Vader in pink -- A delicate balance -- Size matters -- In cancer, perfect is important -- "I think your kidneys did you a favor" -- A successful partnership -- You and your docs: allies, not adversaries.

Executive summary -- 1. Introduction -- 2. Components of a national health information infrastructure -- 3. Federal leadership and public-private partnerships -- 4. Health care data standards -- 5. Comprehensive patient safety programs in health care settings -- 6. Adverse event analysis -- 7. Near miss analysis -- 8. Patient safety reporting systems and applications -- 9. Standardized reporting.

"With coverage ranging from the influence of professional identity in medicine and problematic nature of "human error", to the psychological and social features that characterize healthcare work, to the safety-critical aspects of interfaces and automation, this book spans the width of the human factors field and its importance for patient safety today. In addition, the book discusses topics such as accountability, just culture, and secondary victimization in the aftermath of adverse events and takes readers to the leading edge of human factors research today: complexity, systems thinking and resilience"--Provided by publisher.

"Each year a vast sum of money is spent on health care around the globe and patient safety has become a serious global public health issue. Filled with up-to-date information, this book demonstrates how to handle patient safety-related problems by using methods developed in the area of engineering. It contains a chapter on mathematical concepts and another chapter on introductory material on safety and human factors considered essential to understand materials presented in subsequent chapters. The author's presentation covers topics in such a manner that readers will require no previous knowledge to understand the concepts"--Provided by publisher.

Integrating State-of-the-Art Computational Modeling with Clinical Practice: The Promise of Numerical Methods / David E. Krummen, Gainyu Oshodi and Sanjiv M. Narayan -- Patient-Specific Modeling of Cardiovascular Dynamics with a Major Role for Adaptation / Theo Arts, Joost Lumens, Wilco Kroon, Dirk Donker and Frits Prinzen, et al. -- Patient-Specific Modeling of Structure and Function of Cardiac Cells / Frank B. Sachse -- Studies of Therapeutic Strategies for Atrial Fibrillation Based on a Biophysical Model of the Human Atria / Laurent Uldry, Nathalie Virag, Jean-Marc Vesin and Lukas Kappenberger -- Patient-Specific Modeling for Critical Care / Maxwell Lewis Neal -- Biomechanical Analysis of Abdominal Aortic Aneurysms / Lambert Speelman, Mariëlle Bosboom, Geert W. H. Schurink and Frans N. v.d. Vosse -- The Cardiac Atlas Project: Towards a Map of the Heart / Michael Backhaus, Jae Do Chung, Brett R. Cowan, Carissa G. Fonseca and Wenchao Tao, et al. -- In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts / Jonathan F. Wenk, Zhihong Zhang, Guangming Cheng, Kay Sun and Joseph C. Walker, et al. -- Modeling of Whole-Heart Electrophysiology and Mechanics: Toward Patient-Specific Simulations / Fijoy Vadakkumpadan, Viatcheslav Gurev, Jason Constantino, Hermenegild Arevalo and Natalia Trayanova -- Personalized Computational Models of the Heart for Cardiac Resynchronization Therapy / Maxime Sermesant and Reza Razavi -- Patient-Specific Modeling of Hypoxic Response and Microvasculature Dynamics / Joanna Nathan and Amina Ann Qutub -- A Computational Framework for Patient-Specific Multi-Scale Cardiac Modeling / Jazmin Aguado-Sierra, Roy C. P. Kerckhoffs, Fred Lionetti, Darlene Hunt and Chris Villongco, et al.

Handling of the lymph node biopsy -- Immunohistology and other diagnostic techniques -- Anatomical and functional components -- Nodular lymphoid infiltrates -- Diffuse lymphoid infiltrations -- Defining microscopic features -- Nodal involvement by leukemias and extranodal lymphomas -- Needle core biopsies and aspirates.

Multiscale data condensation -- Unsupervised feature selection -- Active learning using support vector machine -- Rough-fuzzy case generation -- Rough-fuzzy clustering -- Rough self-organizing map -- Classification, rule generation and evaluation using modular rough-fuzzy MLP.

Review of immunology -- Immunology of IgE-mediated and other hypersensitivity responses -- Biochemical mediators of allergic reactions -- Evaluation and management of immune deficiency in allergy practice -- Evaluation of eosinophilia -- Allergens and other factors important in atopic disease -- Airborne pollen prevalence in the United States -- Diagnosis of immediate hypersensitivity -- Physiologic and biologic evaluation of allergic lung diseases -- Radiologic evaluation of allergic and related diseases of the upper airway -- Radiologic evaluation of allergic and related diseases of the lower airway -- Chronic rhinosinusitis role of rhinoscopy and surgery -- Principles of immunologic management of allergic diseases due to extrinsic antigens -- Anaphylaxis -- Allergy to stinging insects -- Erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis -- Drug allergy -- Food allergies -- Asthma -- The infant and toddler with asthma -- Management of acute severe asthma -- Asthma clinical trials -- Hypersensitivity pneumonitis -- Allergic bronchopulmonary aspergillosis -- Occupational immunlogic lung disease -- Allergic rhinitis -- Nasal polyposis, sinusitis, and nonallergic rhinitis -- Allergic diseases of the eye and ear -- Atopic dermatitis -- Contact dermatitis -- Urticaria, angioedema, and hereditary angioedema -- Approach to the patient with pruritus -- Antihistamines -- β [beta] agonists -- Corticosteroids in treatment of allergic diseases -- Other antiallergic drugs: cromolyn, nedocromil, antileukotrienes, anticholinergics, and theophylline -- Delivery devices for inhaled medications -- Novel immunologic therapies -- Allergic disorders and pregnancy -- Eosinophilic esophagitis -- Chronic cough -- Sleep disorders in the allergic patient -- Management of the psychologically complicated patient -- Controversial and unproved methods in allergy diagnosis and treatment.

Part 1. PCR Fundamentals -- Part 2. Clinical Aspects and Diagnosis of Infectious Disease -- Part 3. PCR Protocols for Bacterial Pathogens -- Part 4. PCR Protocols for Viral Pathogens -- Part 5. PCR Protocols for Fungal and Parasitic Pathogens -- Part 6. Susceptibility Screening.

Conformation-Sensitive Capillary Electrophoresis / Emma Jane Ashton -- Conformation Sensitive Gel Electrophoresis / Marian Hill -- Denaturing HPLC for Mutation Screening / Mike Mitchell, Jacqueline Cutler -- In Situ Detection of Human Papillomavirus DNA After PCR-Amplification / Gerard J. Nuovo -- LATE-PCR and Allied Technologies: Real-Time Detection Strategies for Rapid, Reliable Diagnosis from Single Cells / Kenneth E. Pierce, Lawrence J. Wangh -- Long-PCR Amplification of Human Genomic DNA / Stephen Keeney -- Human Papilloma Virus Strain Detection Utilising Custom-Designed Oligonucleotide Microarrays / Duncan Ayers, Mark Platt, Farzad Javad, Philip J. Day -- Multiplex Ligation-Dependent Probe Amplification (MLPA®) for the Detection of Copy Number Variation in Genomic Sequences / Petra G. Os, Jan P. Schouten -- Screening for Genomic Rearrangements by Multiplex PCR/Liquid Chromatography / Claude Houdayer, Catherine Dehainault, Marion Gauthier-Villars, Dominique Stoppa-Lyonnet -- Mutation Surveyor: Software for DNA Sequence Analysis / Jayne A. Minton, Sarah E. Flanagan, Sian Ellard -- Non-invasive Prenatal Diagnosis / Cathy Meaney, Gail Norbury -- Automated DNA Sequencing / Yvonne Wallis, Natalie Morrell -- Phylogenetic Microarrays for Cultivation-Independent Identification and Metabolic Characterization of Microorganisms in Complex Samples / Alexander Loy, Michael Pester, Doris Steger -- Prenatal Detection of Chromosome Aneuploidy by Quantitative-Fluorescence PCR / Kathy Mann, Erwin Petek, Barbara Pertl -- Use of Robotics in High-Throughput DNA Sequencing / Stephen Keeney -- Detection of Factor V Leiden and Prothrombin c.20210G>A Allele by Roche Diagnostics LightCycler® / Peter C. Cooper -- RT-PCR for the Detection of Translocations in Bone and Soft Tissue Tumours in Formalin-Fixed Paraffin-Embedded Tissues / Ann Williams, D. Chas Mangham -- Detection of Minimal Residual Disease in Leukaemia by RT-PCR / Joanne Mason, Mike Griffiths -- Mutation Detection by Southern Blotting / Gillian Mellars, Keith Gomez.

Setup of a PCR Laboratory / Zaheer Khan -- Long-Range PCR with a DNA Polymerase Fusion / Holly H. Hogrefe, Michael C. Borns -- Isolation of Genomic Insertion Sites of Proviruses Using Splinkerette-PCR-Based Procedures / Bin Yin -- Lariat-Dependent Nested PCR for Flanking Sequence Determination / Daniel J. Park -- CODEHOP PCR and CODEHOP PCR Primer Design / Jeannette P. Staheli, Richard Boyce, Dina Kovarik, Timothy M. Rose -- Sequencing of Difficult DNA Regions by SAM Sequencing / Keith R. Mitchelson -- A Global Single-Cell cDNA Amplification Method for Quantitative Microarray Analysis / Kazuki Kurimoto, Mitinori Saitou -- Quantitation of MicroRNAs by Real-Time RT-qPCR / Caifu Chen, Ruoying Tan, Linda Wong, Richard Fekete, Jason Halsey -- High-Throughput SuperSAGE / Hideo Matsumura, Kentaro Yoshida, Shujun Luo, Detlev H. Krüger, Günter Kahl, Gary P. Schroth, Ryohei Terauchi -- Deep Cap Analysis of Gene Expression / Junpei Kurosawa, Hiromi Nishiyori, Yoshihide Hayashizaki -- Linking Emulsion PCR Haplotype Analysis / James G. Wetmur, Jia Chen -- PAP-LMPCR: An Improved, Sequence-Selective Method for the In Vivo Analysis of Transcription Factor Occupancy and Chromatin Fine Structure / Richard Ingram, Arthur Riggs, Constanze Bonifer -- The Many Faces of MLPA / Thomas Ohnesorg, Erin Turbitt, Stefan J. White -- Assessing Gene-Specific Methylation Using HRM-Based Analysis / Ee Ming Wong, Alexander Dobrovic -- Alu PCR / Maurizio Cardelli -- Asynchronous PCR / Caifu Chen, David Ruff, Jason Halsey -- Novel Applications of PCR Through the Use of DNA Substrates / Stuart M. Wilson -- Enhanced Solid Phase PCR for Increased Loading of Amplicon onto Solid Support / Daniel J. Park -- Application of Blocking Oligonucleotides to Improve Signal-to-Noise Ratio in a PCR / Hege Vestheim, Bruce E. Deagle, Simon N. Jarman -- Asymmetric Overlap Extension PCR Method for Site-Directed Mutagenesis / Yue-Hua Xiao, Yan Pei -- Ribosome Display: A Technology for Selecting and Evolving Proteins from Large Libraries / Birgit Dreier, Andreas Plückthun -- GLOBE: Analysis of DNA-Protein Interaction Analysis / Takaaki Kojima, Hideo Nakano -- PCR DNA-Array Profiling of DNA-Binding Transcription Factor Activities in Adult Mouse Tissues / Yimin Sun, Jing Cheng, Keith R. Mitchelson -- Nucleotide Exchange and Excision Technology DNA Shuffling and Directed Evolution / Janina Speck, Sabine C. Stebel, Katja M. Arndt, Kristian M. Müller.

Optic Nerve: The Glaucomatous Optic Nerve -- Optic Nerve: Clinical Examination -- Optic Nerve: Heidelberg Retinal Tomography -- Optic Nerve: Scanning Laser Polarimetry -- Optic Nerve: Optical Coherence Tomography -- Optic Nerve: Comparison of Technologies -- Optic Nerve: Atypical Nerves and Nerve Findings -- IOP: The Importance of Intraocular Pressure -- IOP: Instruments to Measure IOP -- IOP: Central Corneal Thickness -- IOP: Corneal Hysteresis -- IOP: Target Pressures -- IOP: Fluctuation -- Gonioscopy: Why Do Indentation? -- Visual Fields: Visual Field Test Strategies -- Visual Fields: Fluctuation and Progression -- Visual Fields: Field Interpretation -- Other Tests in Glaucoma: Genetic Testing -- Other Testing in Glaucoma: Optic Nerve Blood Flow I -- Other Tests in Glaucoma: Optic Nerve Blood Flow II -- Other Tests in Glaucoma: Multifocal Visual Evoked Potential -- Risk Factors -- Risk Factors: The Risk Calculator - Medical Treatment: First Line Agents and Monotherapy -- Medical Treatment: The Pregnant and Nursing Woman -- Medical Treatment: Carbonic Anhydrase Inhibitors -- Medical Treatment: Osmotic Agents -- Medical Treatment: Neuroprotection -- Medical Treatment: Treated vs. Untreated Glaucoma and Ocular Hypertension -- Medical Treatment: Adherence and Persistence -- Medical Treatment: Alternative Medicine and Glaucoma -- Procedural Treatments: Laser Trabeculoplasty -- Procedural Treatments: Endoscopic Cyclophotocoagulation -- Procedural Treatments: Transcleral Cyclophotocoagulation -- Procedural Treatments: Trabeculectomy -- Procedural Treatments: Perioperative Medication -- Procedural Treatments: Bleb Needling -- Procedural Treatments: Glaucoma Drainage Devices -- Procedural Treatments: New Surgical Options -- Procedural Treatments: Ex-PRESS Mini Glaucoma Shunt -- Procedural Treatments: Phacotrabeculectomy -- Procedural Treatments: Surgery in End-Stage Glaucoma -- Glaucomas: Managing Normal-Tension Glaucoma -- Glaucomas: Pseudoexfoliation Glaucoma -- Glaucomas: Pigment Dispersion Glaucoma and Angle Recession Glaucoma -- Glaucomas: Sturge Weber Syndrome -- Glaucomas: Glaucoma and the Cornea -- Glaucomas: Uveitic Glaucoma -- Glaucomas: Neovascular Glaucoma -- Pediatric Glaucoma: IOP, Axial Length, and Surgery Indications -- Pediatric Glaucoma: Glaucoma Medications and Steroids -- Pediatric Glaucoma: Angle Surgery and Glaucoma Drainage Devices -- Pediatric Glaucoma: Trabeculectomy and Glaucoma Drainage Devices -- Angle-Closure Glaucoma: Risk Factors -- Angle-Closure Glaucoma: Iridotomy -- Angle-Closure Glaucoma: Imaging -- Angle-Closure Glaucoma: Medical Therapy -- Angle-Closure Glaucoma: Surgical Management of Acute Angle-Closure Glaucoma -- Complications: Hypotony -- Complications: Bleb Leaks -- Complications: Blebitis.

The sound phenomena investigated / J. Hirschberg, T. Szende, P. Koltai -- Review of the literature. historical background / J. Hirschberg -- Patients / J. Hirschberg, P. Koltai, Z. Farkas -- Methods -- Characterization and acoustic description of the most commonly occurring sound signals / T. Szende, J. Hirschberg -- Airway and neurological diseases with pathological sounds.

Office evaluation of the child and adolescent -- Ambiguous genitalia in the newborn -- Vulvovaginal problems in the prepubertal child -- The physiology of puberty -- Precocious puberty -- Delayed puberty -- Amenorrhea in the adolescent -- Dysfunctional uterine bleeding -- Androgen abnormalities in the adolescent girl -- Structural abnormalities of the female reproductive tract -- Gynecologic pain : dysmenorrhea, accute and chronic pelvic pain, endometriosis, and premenstrual syndrome -- Education of the child and adolescent -- Pediatric urology in the pediatric and adolescent girl -- Vulvovaginal complaints in the adolescent -- Bacterial sexually transmitted infections : gonorrhea, chlamydia, pelvic inflammatory disease, and syphilis -- Human immunodeficiency virus in young women -- Human papillomavirus infection in children and adolescents -- Benign and malignant ovarian masses -- The breast : examination and lesions -- Contraception -- Teen pregnancy -- Adolescent sexuality -- Gynecologic issues in young women with chronic diseases -- Sexual abuse in the child and adolescent -- Complementary and alternative medicine for gynecology patients -- Legal issues in pediatric and adolescent gynecology.

1. Bone cell biology: osteoclasts, osteoblasts, osteocytes / Katharine Jähn and Lynda F. Bonewald -- 2. Bone matrix and mineralization / Marc D. McKee and William G. Cole -- 3. Prenatal bone development / Fanxin Long -- 4. Postnatal bone growth: growth plate biology, bone formation, and remodeling / Christa Maes and Henry M. Kronenberg -- 5. Dental development and maturation, from the dental crypt to the final occlusion / Jean-Marc Retrouvey, Michel Goldberg and Stéphane Schwartz -- 6. Parathyroid hormone and calcium homeostasis / John T. Potts and Thomas J. gardella -- 7. Phosphate homeostasis regulatory mechanisms / Clemens Bergwitz and Harald Jüppner -- 8. Vitamin D biology / René St-Arnaud and Marie B. Demay -- 9. Peak bone mass and its regulation / Jean-Philippe Bonjour ... [et al.] -- 10. Pregnancy and lactation / Ann Prentice -- 11. Fetal mineral homeostasis / Christopher S. Kovacs -- 12. Radiology / Judith E. Adams ... [et al.] -- 13. Non-invasive techniques for bone mass measurement / Mary B. Leonard and Laura K. Bachrach -- 14. Assessment of maturation: bone age and pubertal assessment / Noël Cameron and David D. Martin --15. Biochemical markers of bone metabolism / Nick Shaw and Wolfgang Högler -- 16. Pediatric bone histomorphometry / frank Rauch -- 17. A diagnostic approach to skeletal dysplasias / Sheila Unger, Andrea Superti-Furga and David L. Rimoin -- 18. The spectrum of pediatric osteoporosis / Maria Luisa Bianchi and Francis H. Glorieux -- 19. Osteogenesis imperfecta / Francis H. Glorieux and David Rowe -- 20. Sclerosing bone dysplasias / Bram Perdu ... [et al.] -- 21. Parathyroid disorders / Murat Bastepe, Harald Jüppner and Rajesh V. Thakker -- 22. Fibrous dysplasia / Paolo Bianco and Shlomo Wientroub -- 23. Nutritional rickets / John M. Pettifor -- 24. Metabolic bone disease in the neonatal period and its later sequelae / Nick Bishop, Mary Pewtrell and Nick Harvey -- 25. Rickets due to hereditary abnormalities of vitamin D synthesis or action / Anthony A. Portale, Farzana Perwad and Walter L. Miller -- 26. Familial hypophosphatemia and related disorders / Ingrid A. Holm, Michael J. Econs and Thomas O. Carpenter --27. Hereditary tubular disorders of mineral handling / Daniella Magen and Israel Zelikovic -- 28. Hypophosphatasia / michael P. Whyte -- 29. Chronic kidney disease mineral and bone disorder / Katherine Wesseling Perry and Isidro B. Salusky -- 30. Extraskeletal bone formation / Eileen M. Shore and Frederick S. Kaplan.

Anesthetic and peroperative management / Monica A. Stokes -- Monitoring of the pediatric cardiac patient / Carol L. Lake and Harvey L. Edmonds -- Physiology and techniques of extracorporeal circulation in the pediatric patient / James A. DiNardo -- Profound hypothermia and circulatory arrest / James A. DiNardo -- Vital organ preservation during surgery for congenital heart disease / Emad B. Mossad and Ibrahim Farid -- Management of postbypass myocardial dysfunction / Laurie K. Davies -- Hemostasis, coagulation, and transfusion in the pediatric cardiac patient / William C. Oliver, Jr. -- Management of postbypass pulmonary hypertension and respiratory dysfunction / Angus McEwan -- -- Septal and endocardial cushion defects / Julie K. Hudson and Jayant K. Deshpande -- Tetralogy of Fallot / William A. Lell and F. Bennett Pearce -- Transposition of the great vessels / James A. DiNardo --Anomalies of the aortic arch and valve / David A. Rosen and Kathleen R. Rosen -- Anomalies of the pulmonary valve and right ventricular outflow tract / Ian Adatia and Helen Holtby -- Tricuspid atresia / Susan Tebich -- Hypoplastic left heart syndrome / George M. Hoffman and Eckehard A.E. Stuth -- Double-outlet right ventricle / Julie K. Hudson and Jayant K. Deshpande -- Truncus arteriosus / Ian M. McKenzie -- Anomalies of systemic and pulmonary venous return / Carol L. Lake -- Abnormalities of the atrioventricular valves / Victor C. Baum -- Coronary artery anomalies / Monica A. Stokes -- Cardiomyopathies / Ian M. McKenzie and Robert G. Weintraub -- Pulmonary hypertension, persistent fetal circulation, and Eisenmenger Syndrome / Paul B. Baines and Andrew Selby -- Pediatric cardiac and lung transplantation / Linda J. Mason ... [et al.] -- Secondary vascular anomalies and cardiac tumors / Steven M. Auden -- Anesthesia for noncardiac surgery in children and adults with congenital heart disease / David Frankville --History of pediatric cardiac anesthesia / Carol L. Lake -- Pediatric heart disease in the developing world / Annette J.M. Davis -- -- Intrauterine development of the cardiovascular system / Carol L. Lake -- Extrauterine development of the cardiovascular system / Peter D. Booker -- Pediatric anesthesia pharmacology / D. Ryan Cook, Peter J. Davis, and Richard J. Ing -- -- Preoperative evaluation and preparation of the pediatric patient with cardiac disease / Ellise Delphin, Ali Inanc Seçkin, and Roger A. Moore -- Cardiac catheterization and other radiographic examinations / Ingrid Hollinger and Alexander Mittnacht -- Pediatric electrocardiography and cardiac electrophysiology / Kevin P. Walsh -- Pediatric echocardiography / Wyman W. Lai, H. Helen Ko, and Ira A. Parness --Postoperative care / Peter D. Booker -- Postoperative cardiovascular dysfunction: pharmacologic support / Peter D. Booker -- Postoperative respiratory function and its management / Lori A. Aronson and Catherine L. Dent -- Renal, gastrointestinal, hepatic, and neurologic dysfunction / Duncan J. Macrae -- Postoperative pain management in the pediatric cardiac patient / Andrew R. Wolf -- Anesthesia for cardiac procedures in the pediatric intensive care unit / Annette J.M. Davis -- -- Quality in pediatric cardiac anesthesia / D. Ryan Cook and Lisa Faberowski -- Teaching pediatric cardiac anesthesiology / Chris Chin and Alan Jay Schwartz.

Chest Ultrasound (US) / Goya Enriquez, Celestino Aso and Xavier Serres -- The Contribution of Nuclear Medicine to Pulmonary Imaging / Michael J. Gelfand and David L. Gilday -- Helical Multidetector Chest CT / Pilar García-Peña and Catherine M. Owens -- High-Resolution CT of the Lung in Children / Javier Lucaya and Hubert Ducou Le Pointe -- Pulmonary Malformations Beyond the Neonatal Period / Josep M. Mata and Amparo Castellote -- CT of Acute Pulmonary Disease: Infection, Infarction, and Trauma / Lane F. Donnelly -- Pediatric Tuberculosis / Pedro A. Daltro and Eloá Nunez-Santos -- How to Perform and Interpret MR Sleep Studies for Obstructive Sleep Apnea in Children / Lane F. Donnelly -- Foreign Body Aspiration: Imaging Aspects / Benjamin Z. Koplewitz and Jacob Bar-Ziv -- Imaging Evaluation of the Thymus and Thymic Disorders in Children / Donald P. Frush -- Lymphoma - Controversies in Imaging the Chest / Sue C. Kaste -- Chest Tumours Other than Lymphoma / Kieran McHugh -- Thoracic Manifestations of Systemic Diseases / Alan S. Brody -- Radiology of the Chest Wall / Georg F. Eich, Christian J. Kellenberger and Ulrich V. Willi -- Pediatric Cardiac MRI / Rajesh Krishnamurthy and Taylor Chung -- Pediatric Cardiac CT / Laureen Sena, Rajesh Krishnamurthy and Taylor Chung -- Fetal MRI of the Chest / Pedro A. Daltro and Heron Werner -- Neonatal Chest Imaging / Janet L. Strife and Eric J. Crotty.

Family interviewing and history-taking / Richard B. Goldbloom -- Skills for culturally sensitive care / Richard B. Goldbloom -- Assessing physical growth and nutrition / Richard B. Goldbloom -- Evaluating the newborn : diagnostic approach / Alexandra A. Howlett, Krista A. Jangaard -- Assessing congenital anomalies / Mark D. Ludman -- Developmental and behavioral assessment / Sarah E. Shea -- Examining the head and neck / D. Anna Jarvis -- Examining the visual system / G. Robert LaRoche -- Evaluating the respiratory system / Daniel M. Hughes -- Cardiovascular assessment of infants and children / Andrew E. Warren, Douglas L. Roy -- Evaluating gastrointestinal symptoms / Mohsin Rashid -- Surgical assessment of the abdomen / Michael Giacomantonio -- Neurological examination / Joseph M. Dooley -- Psychiatric assessment of children and adolescents / Harriet L. MacMillan, Jan Ellen Fleming, Ellen Jamieson -- Musculoskeletal examination / Bianca A. Lang -- Clinical endocrine evaluation / Elizabeth A. Cummings, Sonia R. Salisbury -- Approaching the adolescent / Alexa L. Bagnell -- Gynecological assessment / Joan B. Wenning -- Assessing the skin / Laura A. Finlayson -- Caring for children with chronic conditions and their families / Richard B. Goldbloom -- Clinical evaluation for possible child abuse / Steven Bellemare -- Assessing the appropriate role for children in health decisions / Nuala P. Kenny, Linda E. Skinner -- Palliative care / Gerri Frager, David LaPierre.

Respiratory system -- Cardiovascular system -- Central nervous system -- Infectious diseases -- Hematology and oncology -- Renal system -- Endocrine system -- Nutrition and the gastrointestinal system -- Immunology -- Metabolic disorders -- Pain management -- Pharmacology and toxicology -- Traumatology -- Statistics -- Ethics.

Fundamentals of Gas Exchange and the Assessment of Oxygenation and Ventilation /John S. Sullivan and Toah A. Nkromah --Oxygen Delivery and Oxygen Consumption in Pediatric Critical Care /Juan A. Gutierrez and Andreas A. Theodorou --Hemodynamics /Scott A. Hagen and Timothy E. Corden --Regional Circulations /Demetris Yannopoulos and Vinay M. Nadkarni --Assessment of Cardiovascular Function /Frank A. Maffei --Overview, Structure and Function of the Nephron /Megan Rashid and George J. Schwartz --Physiology of Skeletal Muscle and the Neuromuscular Junction /Ellen D. Iannoli and Michael P. Eaton --Assessment of Neurologic Function /Elizabeth E. Scarlett, Brandi N. Peachey and Jill M. Gotoff --Endothelial Interactions and Coagulation /Trung C. Nguyen and Joseph A. Carcillo --The Inflammatory Response /Mark W. Hall --Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit /Neal J. Thomas, Mary K. Dahmer and Michael W. Quasney --Conventional Mechanical Ventilation /Joseph D. Tobias --Non-conventional Mechanical Ventilation /Michael D. Dettorre --Mechanical and Electrical Myocardial Support /Sabrina S. L. Tsao, Kendra M. Ward and Denise M. Goodman --Renal Replacement Therapies and Other Extracorporeal Therapies /Andrew L. Schwaderer and Marc B. Lande --Pharmacology /Gretchen L. Brummel and Steven E. Lucking --Cardiovascular Drug Therapy /Frank A. Maffei --Sedation and Analgesia /Richard L. Lambert, Lela W. Brink and Frank A. Maffei.Neuromuscular Blockade /Michael P. Eaton and A. Marika Stone --Use of Blood Products /Jill M. Cholette and Norma B. Lerner --Nutrition in Critical Illness /Margaret A. Satchell --Upper Airway Obstruction /Steven E. Lucking --Severe Asthma /Neal J. Thomas and Frank A. Maffei --Acute Respiratory Distress Syndrome /Frank A. Maffei and Neal J. Thomas --Acute Pulmonary Infections /Karen S. Powers --Circulatory Failure/Shock /Hector R. Wong --Sepsis /Angela Lorts, Timothy T. Cornell and Thomas P. Shanley --Multiple Organ Dysfunction Syndrome /Nikoleta S. Kolovos and Barry P. Markovitz --Disorders of Cardiac Rhythm /William G. Harmon --Post-operative Cardiac Care /Surender Rajasekaran and John C. Ring --Cerebral Resuscitation and Traumatic Brain Injury /Ericka L. Fink, Patrick M. Kochanek and Robert S. B. Clark --Neurological Diseases in Pediatric Critical Care Medicine /Michael J. Bell and Aditi Sharangpani --The Approach to the Critically Ill Infant /Frank A. Maffei --Nosocomial Infections /Elise W. van der Jagt --Fluid/Electrolyte/Acid-Base Abnormalities /Michael L. Moritz --Acute Kidney Injury /William S. Varade and Elif Erkan --Acute Liver Injury and Failure in Children /Richard L. Lambert --Hematology and Oncology in Critical Illness /Leonardo R. Brandão, Scott C. Howard, Kenneth W. Gow, Surender Rajasekaran and Robert F. Tamburro --Critical Care Endocrinology /Kecha A. LynShue and Mark A. Sperling --Metabolic Crises /Paul J. Bellino --Trauma/Burn /Robert E. Cilley and Eric H. Bradburn --Toxicology for the Pediatric Intensivist /L. Eugene Daugherty and Frank A. Maffei.

Volume 1 -- Basic science and principles of diagnosis and treatment -- Neonatal and inherited disorders -- Diseases of mucous membranes and appendageal structures -- Volume 2 -- Reaction patterns -- Neoplasms and systemic diseases -- Infections and infestations -- Injury and responses.

Aerobic fitness: what are we measuring? / N. Armstrong, J.R. Welsman -- Anaerobic fitness tests: what are we measuring? / E. Van Praagh -- Secular changes in pediatric aerobic fitness test performance: the global picture / G.R. Tomkinson, T.S. Olds -- Physical fitness of children and adolescents in the United States: status and secular change / R.M. Malina -- Fitness of Canadian children: range from traditional Inuit to sedentary city dwellers, and assessment of secular changes / R.J. Shephard -- Who are the Eurofittest? / G.R.Tomkinson, T.S. Olds, J. Borms -- Changes in Eurofit test performance of Estonian and Lithuanian children and adolescents (1992-2002) / T. Jürimäe ... [et al.] -- Evolution and variability in fitness test performance of Asian children and adolescents / D.J. Macfarlane, G.R.Tomkinson --Secular changes in aerobic fitness test performance of Australasian children and adolescents / G.R.Tomkinson, T.S. Olds -- Prevalence, trends, and environmental influences on child and youth physical activity -- J. Salmon, A. Timperio -- Evolution of maximal oxygen uptake in children / T.W. Rowland -- Distributional changes in the performance of Australian children on tests of cardiorespiratory endurance / J. Dollman, T.S. Olds -- Declines in aerobic fitness: are they only due to increasing fatness? / T.S. Olds, K. Ridley, G.R. Tomkinson.

Pathogenesis of inflammatory bowel disease / di Nardo, G., Cucchiara, S. -- Epidemiology in pediatric inflammatory bowel disease / Koletzko, S. -- Genetics of inflammatory bowel disease / Cooney, R., Jewell, D. -- Pathology of inflammatory bowel disease in children / Harpaz, N. -- Early-onset inflammatory bowel disease : infant, toddler, and pre-school / Lebenthal, E., Branski, D., Walker-Smith, J.A. -- Radiological and imaging features / Laghi, A. ... [et al.] -- Endoscopic modalities in pediatric inflammatory bowel disease / Venkatesh, K., Thomson, M. -- Approach to clinical diagnosis of inflammatory bowel disease / Bousvaros, A. -- Growth and puberty in inflammatory bowel disease / Savage, M.O., Mark Beattie, R., Sanderson, I.R.S. -- Treatment by enteral nutrition in inflammatory bowel disease / Köglmeier, J., Heuschkel, R. -- Medical therapy for inflammatory bowel disease in children and adolescents / Kappelman, M.D., Rufo, P.A. -- Surgical therapy / McCrudden Erickson, K., Teitelbaum, D.H., Coran, A.G. -- Transition to adult care / Hait, E.J. ... [et al.].

Shut-down interview and relationships -- Medical interview: the opening phase -- History of present illness -- Concluding phase -- Family -- Well-child visit -- Primary care and child mental health -- Sensitive topics: suicidality, child abuse -- Supporting families expressing grief while giving bad news -- Challenging patients -- Wandering interviews -- Using experiential techniques to teach interviewing skills -- Glossary of interviewing terms.

Introduction and historical background: pediatric Hodgkin lymphoma -- Biology and pathology of Hodgkin's disease -- Treatment of pediatric Hodgkin lymphoma -- Treatment of relapsed/refractory Hodgkin lymphoma -- Non-Hodgkin's lymphoma: introduction and historical background -- Biology and pathology of pediatric non-Hodgkin lymphoma -- B-cell lymphoma/ Burkitt lymphoma -- Anaplastic large-cell lymphoma -- Precursor B and precursor T-cell lymphoblastic lymphoma -- Cutaneous T-cell lymphomas and rare T-cell non-Hodgkin lymphomas -- Lymphoproliferative disorders related to immunodeficiencies -- Late effects following lymphoma treatment.

Why Should We Write a Book on Pediatric Metabolic Syndrome? Commentaries from Worldwide Experts /Arthur S. Agatston, Arthur S. Agatston, Arthur S. Agatston, Shari Barkin and Gerald S. Berenson, et al. --Epidemiology of the Metabolic Syndrome in Youth: A Population-to-Clinical-Based Perspective /Sarah E. Messiah, Kristopher L. Arheart and James D. Wilkinson --Perinatal Epidemiology of Metabolic Syndrome Risk Factors /Barbara Luke and Mary L. Hediger --Metabolic Syndrome in Childhood as a Risk Factor for Type 2 Diabetes /Nicola Santoro, Cosimo Giannini and Sonia Caprio --Effects of Metabolic Syndrome on Atherosclerosis in Childhood /Muhammad Yasir Qureshi, Sarah E. Messiah, Tracie L. Miller and Steven E. Lipshultz --Metabolic Syndrome and Associated Kidney Disease /Carolyn L. Abitbol and Wacharee Seeherunvong --Metabolic Syndrome and Related Liver Diseases /Aymin Delgado-Borrego.The Relationship Between Asthma, Sleep Apnea, and Other Respiratory Disorders and Childhood Metabolic Syndrome /Erick Forno and Annabelle Quizon --The Relationship Between Components of the Metabolic Syndrome and Bone Health /Zeina M. Nabhan and Linda A. DiMeglio --The Relationship of Childhood Obesity with Cardiomyopathy and Heart Failure /Muhammad Yasir Qureshi, James D. Wilkinson and Steven E. Lipshultz --Childhood Metabolic Syndrome and Cancer Risk /Stefanie R. Brown and Steven E. Lipshultz --Neurocognitive and Psychological Correlates of Metabolic Syndrome in Childhood /Anna Maria Patino-Fernandez, Amber Daigre and Alan M. Delamater --Genomics of Pediatric Metabolic Syndrome /Evadnie Rampersaud and Maria A. Ciliberti --Physical Activity Assessment and Intervention /Gabriel Somarriba --Nutritional Evaluation and Intervention /Runa Diwadkar Watkins, Daniela Neri and Tracie L. Miller --Pharmacological Therapies of Metabolic Syndrome /Adriana Carrillo-Iregui and Carley Gomez-Meade --Bariatric Surgery to Reverse Metabolic Syndrome in Adolescents /Noor Kassira, Valerie Ann Marks and Nestor de la Cruz-Muñoz --Moving Clinic- and Community-Based Practice into Policy to Address Child Healthy Weight (and Vice Versa) /Danielle Hollar, T. Lucas Hollar and Michelle A. Lombardo.

v. 1. Sections 1-6 -- v. 2. Sections 7-12.

Techniques and methods in pediatric neuroimaging -- Normal development of the neonatal and infant brain, skull, and spine -- Toxic and metabolic brain disorders -- Brain and spine injuries in infancy and childhood -- Congenital malformations of the brain and skull -- The phakomatoses -- Intracranial, orbital, and neck masses of childhood -- Hydrocephalus -- Congenital anomalies of the spine -- Neoplasms of the spine -- Infections of the nervous system -- Anomalies of cerebral vasculature: diagnostic and endovascular considerations.

Techniques and methods in pediatric neuroimaging / Christopher P. Hess and A. James Barkovich -- Normal development of the neonatal and infant brain, skull and, spine / A. James Barkovich and Pratik Mukherjee -- Metabolic, toxic, and inflammatory brain disorders / A. James Barkovich and Zoltan Patay -- Brain and spine injuries in infancy and childhood / Erin Simon Schwartz and Jim Barkovich -- Congenital malformations of the brain and skull / A. James Barkovich and Charles A. Raybaud -- The phakomatoses / Gilbert Vezina and A. James Barkovich -- Intracranial, orbital, and neck masses of childhood / Charles Raybaud and A. James Barkovich -- Hydrocephalus / A. Raybaud and A. James Barkovich -- Congenital anomalies of the spine / Erin Simon Schwartz and A. James Barkovich -- Neoplasms of the spine / A. James Barkovich -- Infections of the developing and mature nervous system / Gary Hedlund and A. James Barkovich -- Anomalies of cerebral vasculature: diagnostic and endovascular considerations / Philip M. Meyers, Van V. Halbach, and A. James Barkovich.

Suggestions for history and physical examination -- Headache -- School problems and attention-deficit hyperactivity disorder -- Abnormal movements -- Behavioral and sleep problems -- Seizures, epilepsy, and related disorders -- Dizziness, fainting, and loss of balance -- Delay or regression of motor development associated with low muscle tone -- Autism and language disorders -- Cerebral palsy (static encephalopathy) and related problems -- Abnormalities of cranial size and shape, hydrocephalus, and spinal dysraphism -- Common neurological complications of trauma -- Stroke, acute paraparesis, and other serious disorders of acute and subacute onset -- Other important neurological syndromes.

Dyslexia / Kytja K.S. Voeller -- Sleep disorders in children / Rafael Pelayo ... [et al.] -- Ischemic stroke in childhood / Peter E. Anderson and Gabrielle A. deVeber -- Neuropsychiatric aspects of blindness and severe visual impairment, and deafness and severe hearing loss in children / Bryan H. King, Peter C. Hauser, and Peter K. Isquith -- Movement disorders / Ergun Y. Uc and Robert L. Rodnitzky -- Epilepsy syndromes in childhood / Rochelle Caplan and Erin Lanphier --Prematurity and cerebral palsy / Agnes Whitaker ... [et al.] -- Traumatic brain injury / Sharon Arffa -- Spina bifida and hydrocephalus / Gregory S. Liptak -- Pediatric brain tumors / David L. Kaye and Patricia K. Duffner.Mental retardation / Suzanne T.P.V. Sundheim, Ruth Mize Myers, and Kytja K.S. Voeller -- Genetic syndromes / Chiara Pantaleoni ... [et al.] -- Neuropsychiatric aspects of autism spectrum disorders and childhood-onset schizophrenia / Natacha Akshoomoff -- Attention deficit-hyperactivity disorder / Kytja K.S. Voeller -- Conduct disorder and sociopathy / Markus J.P. Kruesi and Kevin Gray -- Pediatric mood disorders / Robert A. Kowatch ... [et al.] -- Anxiety disorders / Sanjeev Pathak and Bruce D. Perry -- Eating disorders / David C. Jimerson, Barbara E. Wolfe, and Silke Naab -- Substance use disorders / Oscar G. Bukstein and Ralph E. Tarter.Normal development of the nervous system / Harvey B. Sarnat and Laura Flores-Sarnat -- Normal childhood growth and development of intellect, language, temperament, emotion, and social skills / Marilyn Augustyn -- Clinical neuropsychiatric assessment of children and adolescents / Paul D. Larsen -- Neuropsychological and psychoeducational testing / Renée Lajiness-O'Neill and Isabelle Beaulieu -- Anatomic imaging of the developing human brain / Jay N. Giedd -- Functional imaging of the developing human brain / Harry T. Chugani and Csaba Juhász -- Clinical electrophysiology of the developing human brain / Leslie J. Carver and Martha Ann Bell.Pediatric psychopharmacology / Daniel A. Geller, Paul Hammerness, and Thomas Spencer -- Electroconvulsive therapy in pediatric neuropsychiatry / C. Edward Coffey -- Genetic evaluation, counseling, and treatment / Carol E. Anderson -- Psychological and behavioral interventions / Robert T. Ammerman and Mariah E. Coe -- Psychoeducational interventions in pediatric neuropsychiatry / Jeffrey A. Miller ... [et al.] -- Selected legal issues / Peter S. Latham and Patricia H. Latham.

v. 1. Brain -- v. 2. Head and neck, spine.

Introduction / S.T. Treves -- Central nervous system: pt. 1, Brain / S.T. Treves, Harry T. Chugani, Blaise F.D. Bourgeois ; pt. 2, Cerebrospinal fluid / S.T. Treves, Alvin Kuruc -- Thyroid / Stephen A. Huang -- Calculation of administered doses of iodine 131 in the treatment of thyroid disease / Robert E. Zimmerman -- Lungs / S.T. Treves, Alan B. Packard -- Cardiovascular system / S.T. Treves, Elizabeth D. Blume, Laurie Armsby, Jane W. Newburger, Alvin Kuruc -- Gastroesophageal reflux, gastric emptying, esophageal transit, and pulmonary aspiration / Zvi Bar-Sever -- Gastrointestinal bleeding / S.T. Treves, Richard J. Grand -- Liver and spleen / S.T. Treves, A.G. Jones -- Kidneys / S.T. Treves, William E. Harmon, Alan B. Packard, Alvin Kuruc -- Vesicoureteral reflux / S.T. Treves, Ulrich V. Willi -- Calculation of glomerular filtration rate / Robert E. Zimmerman, Karl Mitchell, Royal T. Davis -- Bone / Leonard P. Connolly, Laura A. Drubach, Susan A. Connolly, S.T. Treves -- Pediatric oncology / Hossein Jadvar, Barry L. Shulkin -- Infection and inflammation / Christopher J. Palestro, Charito Love, Maria B. Tomas -- Magnification / Royal T. Davis, Robert E. Zimmerman, S.T. Treves -- Single positron emission computed tomography / Frederic H. Fahey, Beth A. Harkness -- Positron emission tomography / Frederic H. Fahey, Ramsey D. Badawi -- Radiation risk / S. James Adelstein -- Internal dosimetry / Michael G. Stabin.

Chapter 1. Overview of pediatric nursing -- Chapter 2. Legal and ethical issues -- Chapter 3. The child in context of the family -- Chapter 4. Community and home health nursing -- Chapter 5. School Nursing -- Chapter 6. Theoretical approaches to the growth and development of children -- Chapter 7. Growth and development of the newborn -- Chapter 8. Growth and development of the infant -- Chapter 9. Growth and development of the toddler -- Chapter 10. Growth and development of the preschooler -- Chapter 11. Growth and development of the school-age child -- Chapter 12. Growth and development of the adolescent -- Chapter 13. Child and family communication -- Chapter 14. Pediatric assessment -- Chapter 15. Infectious Diseases -- Chapter 16. Care of children who are hospitalized -- Chapter 17. Chronic conditions -- Chapter 18. Pain management -- Chapter 19. Medication administration -- Chapter 20. Loss and bereavement -- Chapter 21. Fluid and electrolyte alterations -- Chapter 22. Genitourinary alterations -- Chapter 23. Gastrointestinal alterations -- Chapter 24. Respiratory alterations -- Chapter 25. Cardiovascular alterations -- Chapter 26. Hematological alterations -- Chapter 27. Immunologic alterations -- Chapter 28. Endocrine alterations -- Chapter 29. Cellular alterations -- Chapter 30. Integumentary alterations -- Chapter 31. Sensory alterations -- Chapter 32. Neurological alterations -- Chapter 33. Cognitive alterations -- Chapter 34. Musculoskeletal alterations -- Chapter 35. Psychosocial alterations -- Chapter 36. Child abuse and neglect.

Chapter 1. Overview of pediatric nursing -- Chapter 2. Legal and ethical issues -- Chapter 3. The child in context of the family -- Chapter 4. Community and home health nursing -- Chapter 5. School Nursing -- Chapter 6. Theoretical approaches to the growth and development of children -- Chapter 7. Growth and development of the newborn -- Chapter 8. Growth and development of the infant -- Chapter 9. Growth and development of the toddler -- Chapter 10. Growth and development of the preschooler -- Chapter 11. Growth and development of the school-age child -- Chapter 12. Growth and development of the adolescent -- Chapter 13. Child and family communication -- Chapter 14. Pediatric assessment -- Chapter 15. Infectious Diseases -- Chapter 16. Care of children who are hospitalized -- Chapter 17. Chronic conditions -- Chapter 18. Pain management -- Chapter 19. Medication administration -- Chapter 20. Loss and bereavement -- Chapter 21. Fluid and electrolyte alterations -- Chapter 22. Genitourinary alterations -- Chapter 23. Gastrointestinal alterations -- Chapter 24. Respiratory alterations -- Chapter 25. Cardiovascular alterations -- Chapter 26. Hematological alterations -- Chapter 27. Immunologic alterations -- Chapter 28. Endocrine alterations -- Chapter 29. Cellular alterations -- Chapter 30. Integumentary alterations -- Chapter 31. Sensory alterations -- Chapter 32. Neurological alterations -- Chapter 33. Cognitive alterations -- Chapter 34. Musculoskeletal alterations -- Chapter 35. Psychosocial alterations -- Chapter 36. Child abuse and neglect.

Acute Leukemia / Michael E. Rytting, Mary S. Choroszy, Demetrios Petropoulos and Ka Wah Chan -- Hodgkin Lymphoma and Non-Hodgkin Lymphoma / Ka Wah Chan, Demetrios Petropoulos, Eric L. Chang and Michael E. Rytting -- Brain Tumors: Diagnosis, Surgery and Radiotherapy, and Supportive Care / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, Bartlett D. Moore and Donna R. Copeland -- Brain Tumors: Chemotherapy and Investigational Therapy / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor and Demetrios Petropoulos -- Wilms' Tumor / Norman Jaffe and Margaret G. Pearson -- Neuroblastoma / Joann L. Ater and Laura L. Worth -- Soft-Tissue Tumors / R. Beverly Raney, Richard J. Andrassy, Martin Blakely, Tina V. Fanning and Moshe H. Maor, et al. -- Osteosarcoma / Norman Jaffe and Margaret G. Pearson -- Ewing's Sarcoma / Cynthia E. Herzog, Anita Mahajan and Valerae O. Lewis -- Retinoblastoma / Misha Faustina, Cynthia E. Herzog and Dan S. Gombos -- Differentiated Thyroid Cancer / Rena Vassilopoulou-Sellin -- Medullary Thyroid Carcinoma / Robert F. Gagel -- Melanoma / Cynthia E. Herzog, Hafeez Diwan, Merrick I. Ross and Victor G. Prieto -- Novel Therapeutic Approaches / Sima S. Jeha and Laura L. Worth -- Supportive Care: Myelosuppression / Nidra I. Rodriguez Cruz, Renee M. Madden and Craig A. Mullen -- Supportive Care: Symptom Control / Renee M. Madden, Susannah E. Koontz-Webb, Donna S. Zhukovsky and Craig A. Mullen -- Behavioral Medicine in Cancer Care / Donna R. Copeland and Martha A. Askins -- The Adolescent and Young Adult Program / Sima S. Jeha and Martha A. Askins.

General aspects of childhood leukemia -- Acute lymphoblastic leukemia -- Acute myelogenous leukemia -- Myelodysplastic syndrome -- Myeloproliferative syndromes (chronic myeloproliferative disorders) -- Non-Hodgkin lymphoma -- Hodgkin disease -- Histiocytoses -- Brain tumors -- Neuroblastoma -- Nephroblastoma (Wilms tumor) -- Soft tissue sarcoma -- Osteosarcoma -- Ewing sarcoma family of tumors -- Retinoblastoma -- Germ cell tumors -- Hepatic tumors -- Emergencies in pediatric oncology -- Oncological nursing care -- Psychology and psychosocial issues in children with cancer.

[Volume one contents]: -- 1. Development of ocular refraction: lessons from animal experiments -- 2. Preschool vision screening: is it worthwhile? -- 3. Modern treatment of amblyopia -- 4. Retinopathy of prematurity: molecular mechanism of disease -- 5. Screening for retinopathy of prematurity -- 6. Controversies in the management of infantile cataract -- 7. Management of infantile glaucoma -- 8. Pediatric ocular oncology -- 9. Paediatric electrophysiology: a practical approach -- 10. Clinical and molecular genetic aspects of Leber's congenital amaurosis -- 11. Childhood stationary retinal dysfunction syndromes -- 12. Childhood retinal detachment --13. Eye manifestations of intrauterine infections -- 14. Nonaccidental injury. The pediatric ophthalmologist's role.[Volume two contents]: -- pt. 1. Optic nerve -- 1. Optic neuritis and multiple sclerosis -- 2. Ischemic optic neuropathies -- 3. Optic disc drusen -- 4. Inherited optic neuropathies -- ch. 5. Optic nerve tumours -- 6. Traumatic optic neuropathy ... -- pt. 2. Investigations -- 7. Imaging the nerve fiber layer and optic disc -- 8. Functional neuroanatomy of the human visual system ... -- 9. Investigating visual function with multifocal visual evoked potentials -- pt. 3. Retinal disorders -- 10. Autoimmune retinopathies -- 11. Retinal research : application to clinical practice -- pt. 4. Systemic disease -- 12. Chorioretinal lesions in infectious diseases of neuroophthalmic interest -- 13. Giant cell arteritis -- pt. 5. Oculomotility -- 14. Cerebral control of eye movements -- 15. Chronic progressive external ophthalmoplegia ... -- 16. Treatment of specific types of nystagmus -- pt. 6. Rehabilitation -- 17. Rehabilitation in neuroophthamology.[Volume three contents]: -- Epidemiology of Pediatric Strabismus / Amy E. Green-Simms and Brian G. Mohney -- Changes in Strabismus Over Time: The Roles of Vergence Tonus and Muscle Length Adaptation / David L. Guyton -- A Dissociated Pathogenesis for Infantile Esotropia / Michael C. Brodsky -- The Monofixation Syndrome: New Considerations on Pathophysiology / Kyle Arnoldi -- Visual Cortex Mechanisms of Strabismus: Development and Maldevelopment / Lawrence Tychsen -- Neuroanatomical Strabismus / Joseph L. Demer -- Congenital Cranial Dysinnervation Disorders: Facts and Perspectives to Understand Ocular Motility Disorders / Antje Neugebauer and Julia Fricke -- The Value of Screening for Amblyopia Revisited / Jill Carlton and Carolyn Czoski-Murray -- The Brückner Test Revisited / Michael Gräf -- Amblyopia Treatment 2009 / Michael X. Repka -- Best Age for Surgery for Infantile Esotropia: Lessons from the Early vs. Late Infantile Strabismus Surgery Study / H. J. Simonsz, G. H. Kolling and Early vs. Late Infantile Strabismus Surgery Study Group -- Management of Congenital Nystagmus with and without Strabismus / Anil Kumar, Frank A. Proudlock and Irene Gottlob -- Surgical Management of Dissociated Deviations / Susana Gamio -- Surgical Implications of the Superior Oblique Frenulum / Burton J. Kushner and Megumi Iizuka -- Pearls and Pitfalls in Surgical Management of Paralytic Strabismus / Seyhan B. Özkan -- Modern Treatment Concepts in Graves Disease / Anja Eckstein and Joachim Esser.

Developmental bone biology -- Imaging approaches for epiphyseal assessment -- Developmental dysplasia of the hip -- Legg-Calve-Perthes Disease -- Coxa Vara in developmental and acquired abnormalities of the femur -- Developmental disorders of the knee -- Deformities due to disorders primarily affecting the epiphyses and metaphyses -- Lower extremity length discrepancies -- Skeletal dysplasias -- Epiphyseal and metaphyseal involvement with metabolic, inflammatory, neoplastic, infectious, and hematologic disorders.

Part 1.Trauma Overview --Polytrauma in the Pediatric Patient /Joshua M. Abzug and Martin J. Herman --The Mangled Extremity in Children /Sapan D. Gandhi, Joshua M. Abzug and Martin J. Herman --Compartment Syndrome /Baxter Willis --Part 2.Spine --Cervical Spine Injuries in Children /Steven W. Hwang, Per D. Trobisch, Andrew Jea and Amer F. Samdani --Thoracic and Lumbar Spine Injuries /Hitesh Garg, Joshua Pahys and Patrick J. Cahill --Part 3.Upper Extremity --Supracondylar Humerus Fractures /Joshua M. Abzug, Dan A. Zlotolow and Scott H. Kozin --Upper Extremity Replantation in Children /Joshua M. Abzug, Dan A. Zlotolow and Scott H. Kozin --Part 4.Lower Extremity --Pediatric Hip Fractures and Dislocations /James J. McCarthy, Kenneth J. Noonan and Sapan D. Gandhi --Pediatric Proximal Tibial Fractures with Vascular Compromise /William Hennrikus and Tamara Pylawka --Open Tibia Fractures in Children and Adolescents /Joseph Rosenblatt and Shannon D. Safier --Part 5.Infection --Septic Hip /Peter D. Pizzutillo and Megan Gresh --Necrotizing Fasciitis /Kevin J. Little and Joshua M. Abzug --Part 6.Other --Slipped Capital Femoral Epiphysis /Panagiotis Peter Glavas and B. David Horn.

Antibiotic therapy for acute otitis, rhinosinusitis, and pharyngotonsillitis -- Pediatric hearing assessment -- Speech, voice and, swallowing assessment -- Methicillin-resistant staphylococcus aureus (MRSA) infections of the head and neck in children -- Polysomnography in children -- Otology -- External otitis -- Diagnosis and management of otitis media -- Tympanostomy tubes and otorrhea -- Chronic disorders of the middle ear and mastoid (tympanic membrane perforations and cholesteatoma) -- Congenital hearing loss (sensorineural and conductive) -- Implantable hearing devices -- Rhinology -- Pediatric facial fractures -- Pediatric epistaxis -- Nasal obstruction in the neonate -- Pediatric allergic nose -- Acute and chronic rhinosinusitis -- Head and neck -- Congenital head and neck masses -- Pediatric stridor -- Inflammatory disorders of the pediatric airway -- Tracheostomy in children -- Cleft lip and palate -- Cough -- Hoarseness in children -- Adenotonsillar disease -- Sleep-disordered breathing (SDB) in children -- Pediatric vascular tumors -- Emergencies in pediatric otolaryngology -- Foreign body management -- Deep space neck infections in the pediatric population -- Complications of acute otitis media -- Complications of sinusitis.

section I. Concept of normality -- ch. 1. Describing normality -- ch. 2. General aspects of history taking and interviewing -- section II. Specific aspects of history taking -- ch. 3. Three basic steps in diagnosis -- ch. 4. History taking by systems -- section III. Physical examination -- ch. 5. General physical examination -- ch. 6. Head, neck and sensory organs -- ch. 7. Chest (including heart and lungs) -- ch. 8. Abdomen and genitalia -- ch. 9. Skin -- ch. 10. Musculoskeletal system -- ch. 11. Central nervous system -- section IV. Special examinations -- ch. 12 A. Physical diagnosis of the newborn -- B. The Adolescent -- C. Developmental and behavioral assessment -- D. Physical and sexual abuse.

Providing family-centered care in pediatric physical therapy / Elena M. Spearing -- Development -- Motor development in the normal child / Emilie J. Aubert -- Assessment and testing of infant and child development / Susan K. Brenneman and Jan Stephen Tecklin -- Neurological disorders -- The infant at high-risk for developmental delay / Diane Versaw-Barnes and Audrey Wood --The infant and child with cerebral palsy / Jane Styer-Acevedo -- Spina Bifida / Elena Tappit-Emas -- Traumatic injury to the central nervous system: brain injury / Amy Both -- Traumatic and atraumatic spinal cord injury in pediatrics / Heather Atkinson and Elena M. Spearing -- Neuromuscular disorders in childhood: physical therapy intervention / Allan M. Glanzman and Jean M. Flickinger -- Mental retardation: focus on Down Syndrome / Dolores B. Bertoti and Dale E. Smith -- Adaptive equipment and environmental aids for children with disabilities / Emilie J. Aubert -- Musculoskeletal disorders -- Orthopedic management / Meg Stanger -- Traumatic disorders and sports injuries / Joe Molony and Donna Merckel -- Juvenile idiopathic arthritis / Susan E. Klepper -- Other medical/surgical disorders -- Pediatric oncology / Victoria Gocha Marchese -- Rehabilitation of the child with burns / Suzanne F. Migliore -- Cardiac disorders / Heather Brossman -- Pulmonary disorders in infants and children and their physical therapy management / Jan Stephen Tecklin -- Physical therapy in the educational environment / Karen Yundt Lunnen and Rita F. Geddes.

"Pediatric Radiation Oncology is the definitive text and reference on use of radiation therapy for childhood cancer. The fifth edition reviews all significant recent clinical trials--including, for the first time, significant European clinical trials--and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer"--Provided by publisher.

Chest radiographs -- Lateral neck radiographs -- Abdominal radiographs -- Skull radiographs -- Long bone and extremity radiographs -- CT scan review.

Pediatric imaging / Johan G. (Hans) Blickman -- Chest / Johan G. (Hans) Blickman and Lya Van Die -- Heart / Rajesh Krishnamurthy and Johan G. (Hans) Blickman -- Gastrointestinal tract / Bruce R. Parker and Johan G. (Hans) Blickman -- Accessory organs of digestion / Bruce R. Parker and Johan G. (Hans) Blickman -- Genitourinary tract / Johan G. (Hans) Blickman and Carla Boetes -- Skeletal system / Johan G. (Hans) Blickman and Geert Vanderschueren -- Brain imaging / Patrick D. Barnes -- Spine imaging / Patrick D. Barnes -- Head and neck imaging / Patrick D. Barnes.

Adolescent medicine / Mark F. Ditmar -- Behavior and development / Mark F. Ditmar -- Cardiology / Thomas J Starc, Constance J. Hayes, and Allan J. Hordof -- Dermatology / Kimberly D. Morel, Vivian A. Lombillo, and Maria C. Garzon -- Emergency medicine / Joan Bregstien, Cindy Ganis Roskind, and F. Meridith Sonnett -- Endocrinology / Sharon E. Oberfield, Mary Pat Gallagher, and Daniel Esten Hale -- Gastroenterology / Andrew B. Grossman and Chris A. Liacouras -- Genetics / Kwame Anyane-Yeboa -- Hematology / Steven E. McKenzie -- Immunology / Georg A. Hollander and Anders Fasth -- Infectious diseases / Mark F. Ditmar -- Neonatology / Philip Roth -- Nephrology / Robert L. Seigle and Martin A. Nash -- Neurology / Kent R. Kelley -- Oncology / Richard Aplenc, Emily G. Lipsitz, and Peter C. Adamson -- Orthopedics / Benjamin D. Roye -- Pulmonology / Robert W. Wilmott and Bradley A. Becker -- Rheumatology / Carlos D. Rose ... [et al.].

The History of Sedation -- Procedural Sedation: Let's Review the Basics - The Pediatrician's Perspective -- Sedation Policies, Recommendations, and Guidelines Across the Specialties and Continents -- Sedation Scales and Discharge Criteria: How Do They Differ? Which One to Choose? Do They Really Apply to Sedation? -- Physiological Monitoring for Procedural Sedation: The Routine and Beyond -- The Pediatric Airway: Anatomy, Challenges, and Solutions -- Pediatric Physiology: How Does it Differ from Adults? -- Pharmacology and Clinical Application of Sedatives, Analgesics, and Adjuncts -- Pharmacokinetics and Pharmacodynamics in the Pediatric Population -- Billing and Reimbursement for Sedation Services -- The Pediatric Hospital Medicine Sedation Service: Models, Protocols, and Challenges -- The Anesthesia Directed Sedation Service: Models, Protocols, and Challenges -- Sedation in the Intensive Care Unit: Challenges, Outcomes, and Future Strategies -- Sedation for Pediatric Gastrointestinal Procedures -- Sedation in the Emergency Department: A Complex and Multifactorial Challenge -- Sedation of Pediatric Patients for Dental Procedures -- Pediatric Sedation: The European Experience and Approach -- Pediatric Sedation in the Underdeveloped Third World: An African Perspective: Models, Protocols, and Challenges -- Pediatric Sedatives and the Food and Drug Administration: Challenges, Limitations, and Drugs in Development -- Incidence and Stratification of Adverse Events Associated with Sedation: Is There a Benchmark? -- Medicolegal Risks and Outcomes of Sedation -- Designing a Safe and Reliable Sedation Service: Adopting a Safety Culture -- Intravenous Infusions for Sedation: Rationale, State of the Art, and Future Trends -- Use of Complementary and Alternative Medicine in Pediatric Sedation -- The Future of Pediatric Sedation.

V.1. Pages 1-768 -- v.2. pages 769-1738.

Office urology -- Pediatric urology facts and figures -- Radiographic imaging -- Urinary tract infections -- Voiding dysfunction, urinary incontinence, and urodynamics -- Hematuria: gross and microscopic -- Office procedures -- Genetic diseases and associated urologic manifestations -- Genitalia -- Penis and scrotum: congenital and acquired anomalies -- Hypospadias -- Varicoceles, hernias, and hydroceles -- Testicles: undescended, retractile, and ascended -- Acute scrotum -- Urinary tract -- Hydronephrosis: prenatal and postnatal -- Vesicoureteral reflux -- Urinary tract obstruction -- Tissue engineering and regenerative medicine: current concepts -- Miscellaeous topics -- Adolescent urology -- Laparoscopy in the pediatric population -- Genitourinary tumors -- Genitourinary trauma.

pt. 1. Foundations of collaborative care -- pt. 2. Collaboration with pediatricians in specific settings -- pt. 3. Collaboration with pediatricians in treatment of specific disorders -- pt. 4. Future directions in pharmacological collaboration.

General pediatrics -- The newborn infant -- The cardiovascular system -- The respiratory system -- The gastrointestinal tract -- The urinary tract -- The neuromuscular system -- Infectious diseases and immunology -- Hematologic and neoplastic diseases -- Endocrine, metabolic, and genetic disorders -- The adolescent.

Part I. Function and Dysfunction of the Pelvic Floor and Viscera -- Functional Anatomy of the Pelvic Floor and Lower Urinary Tract / Daniele Perucchini and John O. L. DeLancey -- Neural Control of Pelvic Floor Muscles / David B. Vodušek -- The Effects of Pregnancy and Childbirth on the Pelvic Floor / Kaven Baessler and Bernhard Schüssler -- Muscle Function and Ageing / Brenda Russell and Linda Brubaker -- Urinary Incontinence and Voiding Dysfunction / Annette Kuhn and Bernhard Schüssler -- Pelvic Organ Prolapse / Peggy A. Norton -- Anal Incontinence, Constipation, and Obstructed Defecation / Abdul H. Sultan and A. Muti Abulaffi -- Overactive Pelvic Floor Muscles and Related Pain / Wendy F. Bower -- Part II. Evaluation of the Pelvic Floor -- Clinical Evaluation of the Pelvic Floor Muscles / Diane K. Newman and Jo Laycock -- Examination of Patients with Pelvic Organ Prolapse / Ursula M. Peschers Urodynamics / Ursula M. Peschers -- Applying Urodynamic Findings to Clinical Practice / Christopher K. Payne -- Anorectal Physiology / David Z. Lubowski and Michael L. Kennedy -- Ultrasound Imaging / Kaven Baessler and Heinz Kölbl -- Magnetic Resonance Imaging / Thomas Treumann, Ralf Tunn and Bernhard Schüssler -- Electrophysiology / Clare J. Fowler and David B. Vodušek -- Outcome Measures in Pelvic Floor Rehabilitation / Kate H. Moore and Emmanuel Karantanis -- Part III. Techniques of Pelvic Floor Rehabilitation and Muscle Training -- Concepts of Neuromuscular Rehabilitation and Pelvic Floor Muscle Training / Jo Laycock -- Exercise, Feedback, and Biofeedback / Pauline E. Chiarelli and Kate H. Moore -- Electrical Stimulation / Wendy F. Bower -- Extracorporeal Magnetic Stimulation / Alastair R. Morris and Kate H. Moore -- Devices / Ingrid Nygaard and Peggy A. Norton -- Alternative Methods to Pelvic Floor Muscle Awareness and Training / Kaven Baessler and Barbara E. Bell -- Part IV. Treatment: Condition-Specific Assessment and Approaches -- Behavioral Treatment / Kathryn L. Burgio -- Stress Urinary Incontinence / Jo Laycock -- Evidence for the Effectiveness of Pelvic Floor Muscle Training in the Treatment and Antenatal Prevention of Female Urinary Incontinence / E. Jean C. Hay-Smith and Kate H. Moore -- Postpartum Management of the Pelvic Floor / Pauline E. Chiarelli -- Role of a Perineal Clinic / Ranee Thakar -- Overactive Bladder / Kathryn L. Burgio, Dudley Robinson and Linda Cardozo -- Sexual Dysfunction and the Overactive Pelvic Floor / Wendy F. Bower -- Anal Incontinence and Evacuation Difficulties / Christine Norton -- Incontinence During Sports and Fitness Activities / Alain P. Bourcier -- Pelvic Organ Prolapse - Pessary Treatment / Jane A. Schulz and Elena Kwon -- Part V. What to Do if Physiotherapy Fails? -- Stress Urinary Incontinence: Choice of Surgery / Stuart L. Stanton -- Genital Prolapse: Surgery for Failed Conservative Treatment / Stuart L. Stanton -- The Anal Sphincter / Klaus E. Matzel, Manuel Besendörfer and Stefanie Kuschel.

Part 1: Prehospital care, diagnostic tools and resuscitation strategies -- Part 2: Surgical strategies in Penetrating Trauma to Head, Face, and Neck -- Part 3: Surgical Strategies in Penetrating Trauma to the Chest -- Part 4: Surgical Strategies in Penetrating Trauma to the Abdomen and Pelvis -- Part 5: Surgical strategies in Penetrating Trauma and Orthopedic Injuries -- Part 6: Peripheral Arterial Injuries -- Part 7: Other topics.

Clinical and epidemiological foundations / Eric Taylor -- Biological foundations / Sarah Curran -- Diagnosis and assessment / Kapil Sayal -- Psychological assessment / Jody Warner-Rogers -- Medical investigations and tests / Angie Stevens and Gillian Baird -- Making a case formulation : differential diagnosis and recognizing comorbidity / Wai Chen -- Education and advice / Maxine Sinclair -- Pharmacotherapy in ADHD / Paramala J. Santosh -- Behavioural and cognitive approaches / Maxine Sinclair -- ADHD and sleep disorders / Paul Gringras, Adam Jaffe and Stephen Sheldon -- Aspects of medical management / Eric Taylor and Peter Hill -- ADHD in preschool children / Margaret Thompson and Edmund Sonuga-Barke -- Hyperactivity disorders in children with mental retardation / Emily Simonoff -- The clinical assessment and treatment of ADHD in adults / Phillip J. Asherson and J.J. Sandra Kooij.

HPLC analysis and purification of peptides / Colin T. Mant ... [et al.] -- Identification of proteins based on MS/MS spectra and location of posttranslational modifications / Kathryn L. Stone ... [et al.] -- Determination of phosphorylated and O-glycosylated sites by chemical targeting (CTID) at ambient temperature / Gary M. Hathaway -- Synthesis, biosynthesis, and characterization of transmembrane domains of a G protein-coupled receptor / Fred Naider -- Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors / Janelle L. Lauer-Fields ... [et al.] -- Proteolytic profiling of the extracellular matrix degradome / Diane Baronas-Lowell ... [et al.] -- [Beta]-amyloid protein aggregation / Marcus A. Etienne ... [et al.] -- Radiometal-labeled somatostatin analogs for applications in cancer imaging and therapy / Jason S. Lewis and Carolyn J. Anderson -- Cell-penetrating proline-rich peptidomimetics / Josep Farrera-Sinfreu ... [et al.] -- Peptide-mediated targeting of liposomes to tumor cells / Evonne M. Rezler ... [et al.] -- Peptide-mediated delivery of nucleic acids into mammalian cells / Sébastien Deshayes ... [et al.] -- Broth microdilution antibacterial assay of peptides / Laszlo Otvos and Mare Cudic -- Depsipeptide synthesis / Maciej Stawikowski and Predrag Cudic.

PNAs as novel cancer therapeutics / Luca Mologni and Carlo Gambacorti-Passerini -- Medicinal chemistry of plasmid DNA with peptide nucleic acids : a new strategy for gene therapy / Olivier Zelphati ... [et al.] -- Locked nucleic acids (LNA) and medical applications / Henrik Ørum, Andreas Wolter and Lars Kongsbak -- Peptide nucleic acids as agents to modify target gene expression and function / Gan Wang and Peter M. Glazer -- Peptide nucleic acids : cellular delivery and recognition of DNA and RNA targets / David R. Corey --Receptor-specific targeting with complementary peptide nucleic acids conjugated to peptide analogs and radionuclides / Eric Wickstrom, Mathew L. Thakur and Edward R. Sauter -- Morpholinos and PNAs compared / James E. Summerton -- Chemistry of locked nucleic acids (LNA) : design, synthesis and bio-physical properties / Jesper Wengel ... [et al.] -- Recent applications of RNA interference (RNAi) in mammalian systems / Lisa Scherer and John J. Rossi -- Peptide nucleic acids as epigenetic inhibitors of HIV-1 / Shizuko Sei -- Therapeutic uses of peptide nucleic acids (PNA) in oncology / Nadia Zaffaroni, Raffaella Villa and Marco Folini --The many faces of PNA / Peter E. Nielsen -- Modulation of nucleic acid information processing by PNAs : potential use in anti-viral therapeutics / Lionel Bastide, Bernard Lebleu and Ian Robbins -- Targeted gene delivery : the role of peptide nucleic acid / Kenneth W. Liang, Feng Liu and Leaf Huang -- Imaging gene expression in the brain with peptide nucleic acid (PNA) antisense radiopharmaceuticals and drug targeting technology / Ruben J. Boado and William M. Pardridge --The use of PNAs and their derivatives in mitochondrial gene therapy / Paul M. Smith ... [et al.] -- Gene silencing through RNA interference: potential for therapeutics and functional genomics / David O. Azorsa, Spyro Mousses and Natasha J. Caplen -- Transcriptional activation of human CREB gene promoter using bis-PNA (peptide nucleic acid) / Christopher G. Janson ... [et al.].

Peptide-based drug design : here and now / Laszlo Otvos, Jr. -- Strategies for the discovery, isolation, and characterization of natural bioactive peptides from the immune system of invertebrates / Philippe Bulet -- Sequence analysis of antimicrobial peptides by tandem mass spectrometry / Christin Stegemann and Ralf Hoffmann -- The spot technique : synthesis and screening of peptide macroarrays on cellulose membranes / Dirk F.H. Winkler and William D. Campbell -- Analysis of A[beta] interactions using ProteinChip technology / Eleni Giannakis ... [et al.] -- NMR in peptide drug development / Jan-Christoph Westermann and David J. Craik -- Molecular dynamics simulations of peptides / Jeffrey Copps, Richard F. Murphy and Sandor Lovas -- Short linear cationic antimicrobial peptides : screening, optimizing, and prediction / Kai Hilpert, Christopher D. Fjell and Artem Cherkasov -- Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach : a tool to identify new bacterial targets amenable to the design of novel antibiotics / Marco Scocchi ... [et al.] -- Serum stability of peptides / Håvard Jenssen and Stein Ivar Aspmo -- Preparation of glycosylated amino acids suitable for Fmoc solid-phase assembly / Mare Cudic and Gayle D. Burstein -- Synthesis of O-phosphopeptides on solid phase / David Singer and Ralf Hoffmann -- Peptidomimetics : Fmoc solid-phase pseudopeptide synthesis / Predrag Cudic and Maciej Stawikowski -- Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines / Brandon Y. Chua, Weiguang Zeng and David C. Jackson -- Synthesis of a multivalent, multiepitope vaccine construct / Laszlo Otvos, Jr. -- Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins / Marina V. Backer ... [et al.].

The discipline of radiation oncology -- Biologic basis of radiation therapy -- Molecular cancer and radiation biology -- Molecular pathophysiology of tumors -- Principles of radiologic physics, dosimetry, and treatment planning -- Photon external-beam dosimetry and treatment planning -- Electron-beam therapy: dosimetry, planning, and techniques -- Three-dimensional conformal radiation therapy: physics, treatment planning, and clinical aspects -- Intensity-modulated radiation treatment techniques and clinical applications -- Image-guided radiation therapy -- Altered fractionation schedules -- Late effects of cancer treatment on normal tissues -- Methodology of clinical trials -- Total-body and hemibody irradiation -- Stereotactic radiosurgery and radiotherapy -- Sterotatic irradiation of tumors outside the central nervous system -- Intraoperative radiotherapy -- Particle beam radiotherapy -- Physics and biology of brachytherapy -- Clinical applications of brachytherapy: low-dose-rate and pulse-dose-rate -- The physics and dosimetry of high-dose-rate brachytherapy -- Clinical aspects and applications of high-dose-rate brachytherapy -- Radioimmunoglobulins and nonsealed radionuclide therapy -- Photodynamic therapy -- Radiation oncology in the developing world -- Chemical modifiers of radiation response -- Oncologic imaging/oncologic anatomy -- Hyperthermia -- Basic concepts of chemotherapy and irradiation interaction -- Skin -- Malignant neoplasms associated with the acquired immunodeficiency syndrome -- Primary intracranial neoplasms -- Pituitary -- Spinal canal -- Eye and orbit -- Ear -- The role of combined radiotherapy and chemotherapy in the management of locally advanced squamous carcinoma of the head and neck -- Nasopharynx -- Nasal cavity and paranasal sinuses -- Salivary glands -- Oral cavity cancer -- Oropharynx -- Hypopharynx cancer -- Larynx -- Unusual nonepithelial tumors of the head and neck -- Management of the neck including unknwon primary tumor -- Thyroid -- Lung -- Mediastinum and trachea --Esophageal cancer -- Tumors of the heart and great vessels -- Breast: stage tis -- Early stage breast cancer -- Breast cancer: locally advanced and recurrent disease, postmastectomy radiation, and systemic therapies -- Stomach -- Cancer of the pancreas -- Liver and hepatobiliary tract -- Colon and rectum -- Anal cancer -- Kidney, renal pelvis, and ureter -- Bladder -- Low-risk prostate cancer -- Intermediate- and high-risk prostate cancer -- Testis -- Penis and male urethra -- Uterine cervix -- Endometrium -- Ovary -- Fallopian tube -- Vagina -- Female urethra -- Carcinoma of the vulva -- Retroperitoneum -- Adrenal gland -- Hodgkin lymphoma -- Non-Hodgkin's lymphoma -- Cutaneous T-cell lymphoma -- Leukemia -- Plasma cell myeloma and plasmacytoma -- Osteosarcoma -- Soft tissue sarcomas (excluding retroperitoneum) -- Central nervous system tumors in children -- Wilms' tumor -- Neuroblastoma -- Rhabdomyosarcoma -- Ewing tumor -- Lymphomas in children -- Unusual tumors in childhood -- Radiotherapy of non-malignant diseases -- Endovascular brachytherapy -- Palliation of brain and spinal cord metastases -- Palliation of bone metastases -- Palliation of visceral recurrences and metastases -- Pain management -- Supportive care and quality of life -- Technology assessment, cost benefit, outcome analysis research and evidence-based radiation oncology -- Ethics, professional values, and legal considerations in radiation oncology -- The economics of radiation oncology.

1. Introduction / D. Watson -- 2. Interactions between stress, food and mood / C.R. Markus -- 3. Mood, cognitive function and nutritional and other supplements / P. Clayton -- 4. The Range of medicinal plants influencing mental and physical performance / T.S.C. Li -- 5. Phyto-oestrogens and cognitive function / S. Kreijkamp-Kaspers and Y.T. van der Schouw -- 6. Ginseng / D.D. Kitts and D.G. Popovich -- 7. Ginkgo biloba and Alzheimer's disease / B.D. Oomah -- 8. Functional ingredients in sports drinks / R.J. Maughan -- 9. Pharmacological functions of green tea polyphenols / T.P. Rao, T. Okubo, D-C. Chu and L.R. Juneja -- 10. Caffeine, mental performance and mood / J.E. James --

We provide a broad overview of human brain development with associated malformations and injuries that occur in the period between early embryogenesis and delivery. The aim of this review is to summarize current understanding of the molecular and environmental cues that shape the developing brain. For each developmental stage, we give examples of disorders that arise from genetic and/or environmental insults to illustrate critical points of neurological susceptibility.

Introduction / Melisa M. Adams -- Reproductive Health Issues / Melisa M. Adams -- Maternal Morbidity / Melisa M. Adams -- Maternal Mortality / Melisa M. Adams -- Infant Morbidity / Melisa M. Adams -- The Continuum of Reproductive Loss from Pregnancy Through Infancy / Melisa M. Adams -- Birth Weight, Gestational Duration, and Fetal Growth / Melisa M. Adams -- Conclusion / Melisa M. Adams.

Perinatal patient safety and professional liability issues /Kathleen Rice Simpson --Integrating cultural beliefs and practices when caring for childbearing women and families /Lynn Clark Callister --Physiologic changes of pregnancy /Susan Tucker Blackburn --Psychosocial adaptation to pregnancy and postpartum /Jeanne Watson Driscoll --Antenatal care /Mary Lee Barron --High-risk pregnancy --Labor and birth /Kathleen Rice Simpson --Fetal assessment during labor /Kathleen Rice Simpson --Pain relief and comfort measures in labor /Patricia A. Creehan --Postpartum care /Dotti C. James --Newborn adaptation to extrauterine life /Debbie Askin --Newborn physical assessment --Newborn nutrition /Jill Janke --Common neonatal complications /Patricia Nash and Joan Renaud Smith.

The site includes data and information for each state, the District of Columbia, Puerto Rico and the United States on prenatal care, low birthweight, infant mortality, poverty, health insurance coverage, and other topics related to maternal and child health.

A historical perspective on the psychiatry of motherhood / I. Brockington -- Diagnostic classification of perinatal mood disorders / A. Riecher-Rössler, A. Rohde -- Maternal adversity, vulnerability, and disease / S.G. Matthews, M.J. Meaney -- Behavioral perinatology / P.D. Wadhwa -- Maternal depression: an adverse early environment / A.J. Beach ... [et al.] -- Perinatal infanticide and suicide / M.G. Spinelli -- Relevance of gonadal hormones to perinatal mood and anxiety disorders / A. Ahokas ... [et al.] --Pharmacotherapy for psychiatric disorders in pregnancy / L.E. Ross ... [et al.] -- Maternal depression in the postpartum period: impact of breast-feeding on treatment planning / Z.N. Stowe, K. Ragan, D.J. Newport -- The use of interpersonal psychotherapy for perinatal mood and anxiety disorders / S. Stuart, M.W. O'Hara -- Group psychotherapy for depression in early stages of motherhood / M. Hofecker-Fallahpour, A. Riecher-Rössler -- Alternative treatment strategies for perinatal depression and anxiety / M. O'Higgins, V. Glover, M. Corral.

Role of the Medical Consultant -- Preoperative Testing -- Perioperative Medication Management -- Perioperative Management of Anticoagulation -- Venous Thromboembolism Prophylaxis -- Prevention of Infective Endocarditis (Bacterial Endocarditis Prophylaxis) -- Surgical Site Infection Prophylaxis -- Anesthesiology for the Nonanesthesiologist -- Abdominal Surgery -- Thoracic Surgery -- Vascular Surgery -- Orthopedic Surgery -- Neurosurgery -- Gynecologic Surgery -- Urologic Surgery -- Bariatric Surgery -- Ophthalmic Surgery -- Otolaryngologic Procedures -- Electroconvulsive Therapy -- Cardiac Disease -- Pulmonary Disease -- Endocrine Disease -- Hematologic Disease -- Cancer -- HIV -- Chronic Kidney Disease -- GI Disease -- Rheumatic Disease -- Neurological Disease -- Psychiatric Conditions -- Substance Abuse -- The Pregnant Surgical Patient -- Postoperative Fever -- Postoperative Hypertension/Hypotension -- Postoperative Arrhythmias -- Perioperative Chest Pain/Dyspnea -- Postoperative Pulmonary Complications -- Postoperative Venous Thromboembolism (DVT and PE) -- Postoperative Fluid, Electrolyte, and Acid/Base Disorders -- Postoperative Renal Failure -- Anemia and Bleeding -- Postoperative Jaundice -- Postoperative Stroke and Seizures -- Postoperative Delirium -- Pain Management.

A history of transfusion / Bruce Spiess and Richard K. Spence -- The contemporary economics of transfusion / Timothy J. Hannon and Kathy Paulson Gjerde -- Blood supplies now and in the future / Mike Fitzpatrick -- Medical ethics, transfusion and the standard of practice / Kenneth Kipnis -- Oxygen transport monitoring: the basis for developing transfusion triggers / Kevin Ward and Ivo Torres Filho -- Physiology of anemia and red blood cell transfusion / Howard Corwin and Paul C. Høbert -- Physiology of hemostasis / Wayne L. Chandler -- Platelet physiology: cellular and protein interactions / Christine S. Rinder -- Iron metabolism and erythopoiesis / Kenneth R. Bridges -- New concepts in oxygen transport / Aryeh Shander, Tanuja S. Rijhwani, and Carmine Gianatiempo -- Infectious risks of transfusion / Eberhard W. Fiebig and Michael P. Busch --Immunomodulation by transfusion / Neil Blumberg and Joanna M. Heal -- Serious acute transfusion reactions / Ira A. Shulman and Aryeh Shander -- A surgeon's guide to blood banking and transfusion medicine / Kimberly W. Sanford and Susan D. Roseff -- Blood storage / Ian Chin-Yee and Richard K. Spence -- Quality control and hospital blood utilization / Kathy Walsh-Kaminsky -- Preoperative autologous donation / F. Mercuriali, G. Inghilleri, and Richard K. Spence -- Erythropoetin therapy / Lawrence T. Goodnough -- Hemoglobin based oxygen carriers / Gregory M.T. Hare and C. David Mazer -- Perfluorocarbon emulsions: artificial gas transport media / Bruce D. Spiess -- Initial resuscitation of the hemorrhaging patient / Richard P. Dutton -- Transfusion and coagulation therapy in trauma and burns / James K. Wright, Harriet W. Hopf, and Lewis J. Kaplan --Acute gastrointestinal bleeding and transfusion management / Richard Peterson, Patricia Parce, and Richard K. Spence -- Coagulation in trauma: dilution and massive transfusion / Richard K. Spence and Anthony Martinez -- Coagulation product use in the perioperative period / Richard K. Spence and Aryeh Shander -- Coagulation monitoring in the perioperative period / Linda Shore-Lesserson and Bruce D. Spiess -- Surgery in patients with acquired platelet and clotting deficiencies / Richard K. Spence and Andrew Green -- Surgery in patients with congenital clotting deficiencies / Richard K. Spence and Andrew Green -- Perioperative implications of anticoagulant and antiplatelet therapy / Jeffrey A. Green -- Pharmacological approaches to prevent or decrease bleeding in surgical patients / Jerrold H. Levy -- Fibrin glue and platelet gel / Bruce Searles and Cody Trowbridge --Anesthesia techniques in blood conservation / Aryeh Shander and Tanuja Rijhwani -- Perioperative red cell salvage and autotransfusion / Jonathan H. Waters -- Intraoperative acute nomovolemic hemodilution / Aryeh Shander and Tanuja S. Rijhwani -- Hypothermia and hemorrhage / Richard P. Dutton -- Surgery in patients with red cell disorders: sickle hemoglobinopathies, polycythemia, and autoimmune hemolytic anemia / Imoigele P. Aisiku -- Surgery in the Jehovah's Witness / Richard K. Spence ... [et al.] -- Coagulation, transfusion, and cardiac surgery / Simon S. Body and David S. Morse -- Blood loss and transfusion alternatives in vascular surgery / Richard K. Spence -- Solid organ transplantation / Nicolas Jabbour, S. Ram Kumar, and Singh Gagandeep -- Blood use in orthopedic surgery / E. Michael Keating and John B. Meding --Blood management in obstetrics and gynecology / Arnold J. Friedman -- Hemorrhage in pediatric patients / Thomas V. Whalen -- Transfusion in oncologic surgery / Patricia A. Ford and Jason Mastoris -- Transfusion and coagulation dysfunction in neurosurgery / Robert S. Graham and J. Chris Zacko -- Transfusion and outcome / Bruce D. Spiess, Richard K. Spence, and Aryeh Shander -- The transfusion decision / Bruce D. Spiess, Richard B. Counts, and Steven A. Gould -- Undertransfusion / Richard K. Spence and Aryeh Shander -- A philosophy of blood management / Aryeh Shander, Richard K. Spence, and Bruce D. Spiess.

Normal TEE Views -- Doppler and Hemodynamics -- Ventricles -- Native Valves -- Prosthetic Valves Transcatheter Valves and Valve Repairs -- Aorta -- Congenital Heart Disease -- Variants, Foreign Material, Masses and Endocarditis -- Ventricular Assist Devices and Heart Transplant -- Hypertrophic Obstructive Cardiomyopathy and Diastolic Dysfunction -- Pericardium.

Evolution of endovascular therapy: diagnostics and therapeutics -- Pathophysiology of vascular disease -- Training and credentialing in vascular and endovascular surgery -- Assessment of vascular patients and indications for therapy -- Anesthesia techniques for endovascular surgery -- Intraprocedural monitoring for endovascular procedures -- Safety considerations for endovascular surgery -- Endovascular intervention suite design -- Angioscopy: instrumentation, techniques, and applications -- Duplex-guided balloon angioplasty from the carotid to the plantar arteries -- Intravascular ultrasound imaging -- Biomaterials: considerations for endovascular devices -- Ancillary endovascular equipment: catheters, guidewires, and procedural considerations -- Balloon angioplasty -- Endovascular intervention for lower extremity deep venous thrombosis -- Remote femoral and iliac artery endarterectomy --Intravascular stents -- Intravascular laser technologies -- Endovascular devices for abdominal aortic aneurysms -- Endovascular devices for thoracic aortic aneurysms -- Critical limb ischemia -- Renal stents -- Inferior vena cava filters: the impact of endovascular technology -- Carotid stenting -- Neuroendovascular interventions -- The current status of hybrid repair of thoracoabdominal aortic aneurysms -- Laparoscopic aortic surgery -- Endovenous surgery -- Thoracic outlet syndrome: endoscopic transaxillary first rib approach: 23 years experience (1985-2008) -- Prevention of lesion recurrence in endovascular devices -- Management of the percutaneous puncture site -- Endovascular practice in Asia-Pacific -- Future imaging and guidance for endovascular procedures.

Pathophysiology of nerve injury and electrodiagnostics -- Cervical radiculopathies, brachial plexopathies, and the burner syndrome -- Proximal upper-extremity nerve injuries -- Distal upper-extremity nerve injuries -- Lumbar radiculopathies -- Lower-extremity nerve injuries -- General principles of peripheral nerve injury rehabilitation -- Rehabilitation of upper-extremity nerve injuries -- Rehabilitation in radiculopathies and lower-extremity peripheral nerve injuries.

Basic concepts and glossary of common clinical terms -- Anatomic classification of peripheral nervous system disorders -- Evaluation and management of the patient with peripheral neuropathy -- Electrodiagnostic, imaging, nerve, and skin biopsy investigations in peripheral nerve diseases -- Case presentations illustrating the diagnostic method -- Acute immune-mediated neuropathies -- Chronic immune-mediated neuropathies -- Neuropathies associated with monoclonal gammopathies and cancer -- Infectious and granulomatous neuropathies -- Diabetic and other endocrine neuropathies -- Neuropathies associated with vitamin deficiencies and malabsorption -- Vascular/ischemic neuropathies -- Neuropathies associated with organ failure -- The hereditary neuropathies -- Hereditary metabolic/multisystem disorders with neuropathy -- The toxic neuropathies : principles of general and peripheral neurotoxicology, pharmaceutical agents -- The toxic neuropathies : industrial, occupational, and environmental agents -- Focal neuropathies : nerve injuries, entrapments, and other mononeuropathies -- Plexopathies -- Disorders of peripheral nerve hyperexcitability.

Ch. 1Viewing the peripheral fundus --Ch. 2Anatomy of the peripheral fundus --Ch. 3Developmental anomalies, degeneration, and diseases of the peripheral retina and pars plana --Ch. 4Vitreous degeneration related to peripheral retinal breaks and retinal detachment --Ch. 5Peripheral retinal breaks --Ch. 6Retinal detachment --Ch. 7Proliferative vitreoretinopathy --Ch. 8Choroidal detachment .

Introduction / Leopold Flohé and J. Robin Harris -- Evolution of the peroxiredoxins / Bernard Knoops, Eléonore Loumaye and Valérie Van Der Eecken -- Structural survey of the peroxiredoxins / P. Andrew Karplus and Andrea Hall -- The catalytic mechanism of peroxiredoxins / Leslie B. Poole -- Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite / Madia Trujillo ... [et al.] -- The peroxiredoxin repair proteins / Thomas J. Jönsson and W. Todd Lowther -- Peroxiredoxins in bacterial antioxidant defense / James M. Dubbs and Skorn Mongkolsuk -- The NADH oxidase-Prx system in Amphibacillus xylanus / Youichi Niimura -- Peroxiredoxin systems in mycobacteria / Timo Jaeger -- Peroxiredoxin systems of protozoal parasites / Marcel Deponte, Stefan Rahlfs and Katja Becker -- The trypanothione system / Luise R. Krauth-Siegel, Marcelo A. Comini and Tanja Schlecker -- Functions of typical 2-Cys peroxiredoxins in yeast / Brian A. Morgan and Elizabeth A. Veal -- The dual function of plant peroxiredoxins in antioxidant defence and redox signaling / Karl-Josef Dietz -- Mitochondrial peroxiredoxins / Zhenbo Cao, J. Gordon Lindsay and Neil W. Isaacs -- Peroxiredoxins in the lung with emphasis on peroxiredoxin VI / Bruno Schremmer ... [et al.] -- Peroxiredoxins in gametogenesis and embryo development / Isabelle Donnay and Bernard Knoops -- Peroxiredoxins in the central nervous system / Fumiyuki Hattori and Shinzo Oikawa -- Stress-induced peroxiredoxins / Tetsuro Ishii and Toru Yanagawa.

Inverted perspectives: triggering change / Tom Munnecke and Robert M. Kolodner -- A window of opportunity / Robert M. Kolodner -- HealthePeople: person-centered, outcomes-driven, virtual health systems / Gary A. Christopherson -- The value of electronic health records / Blackford Middleton -- Personal outcomes in health care / Thomas L. Garthwaite -- Human factors: changing systems, changing behaviors / Marion J. Ball and Judith V. Douglas -- Laying the foundations: information architecture for HealthePeople / James E. Demetriades -- Critical areas of standardization / Jeffrey S. Blair and Simon Cohn -- The role of terminology in future health information systems / Steven H. Brown, Michael J. Lincoln, and Peter L. Elkin --Modeling for health care / Kenneth S. Rubin, Thomas Beale, and Bernd Blobel -- HealthePeople security architecture / Bernd Blobel and John M. Davis -- Open source health systems / Dipak Katra and David Forslund -- Critical standards convergence / Steven Wagner and J. Michael Fitzmaurice -- A European perspective on the cultural and political context for deploying the electronic health record / Angelo Rossi Mori and Gerard Freriks -- Convergence toward the Pan-Canadian electronic health record / Julie Richards, Shari Dworkin, and Nancy Gill -- HealthConnect: a health information network for all Australians / David Rowlands -- The Veterans Health Administration: quality, value, accountability, and information as transforming strategies / Jonathan B. Perlin and Robert M. Kolodner.

The next frontier for user-centered design : making user representations more usable -- The persona lifecycle : a framework for the persona approach -- Phase 1: Family planning (planning a persona effort) -- Phase 2: Conception & gestation (creating personas) -- Phase 3: Birth & maturation (launching and communicating personas) -- Phase 4: Adulthood (using personas) -- Phase 5: Lifetime achievement and retirement (ROI and reuse of personas) -- Contributed chapters: Users, roles and personas / by Larry Constantine -- Storytelling and narrative / by Whitney Quesenbery -- Reality and design maps / by Tamara Adlin & Holly Jamesen -- Marketing versus design personas / by Bob Barlow-Busch -- Why personas work : the psychological evidence / by Jonathan Grudin -- Appendix A: G4K organizational archetype and sample persona -- Appendix B: Example personas from real projects -- Appendix C: Sample image release form.

Another view of psychotherapy? / Herbert J. Schlesinger -- Personality in context : reflections on the contributions of David Shapiro / Paul L. Wachtel -- A new developmental foundation for David Shapiro's work on autonomy and character / E. Virginia Demos -- Two configurations of personality development and psychopathology : etiologic and therapeutic implications / Sidney J. Blatt -- Autonomy and schizophrenia : reflections on an ideal / Louis A. Sass -- Reconceptualizing defense, unconscious processes, and self-knowledge : David Shapiro's contribution / Morris N. Eagle -- Defensive styles of thinking to prevent dreaded states of mind / Mardi J. Horowitz -- Self-deceptive speech : a psycholinguistic view / Michael F. Schober and Peter J. Glick -- Neurotic self-deception as a reproductive strategy / Lawrence Josephs -- David Shapiro's characterology and complex systems theory / Craig Piers -- I don't want to want to : intentionality and craving in addiction / Mindy Greenstein -- Activity, passivity, and the subjective experience of hypomania / Andreas Evdokas and Ali Khadivi -- Appendix A : On two fundamental categories of psychopathology / David Shapiro -- Appendix B : Publications by David Shapiro.

KM and urban health. Knowledge management for the urban health context / M. Chris Gibbons, Rajeev K. Bali, and Nilmini Wickramasinghe -- Healthcare knowledge management : incorporating the tools technologies strategies and process of KM to effect superior healthcare delivery / Nilmini Wickramasinghe -- Knowledge Management in the urban health context : moving towards tacit-to-tacit knowledge transfer / Rajeev K. Bali, Vikram Baskaran, and Raouf N.G. Naguib -- Incorporating KM principles into urban health contexts. A childhood/adolescent knowledge management system for urban area health programs in the District of Columbia / Michael L. Popovich and Xiaohui Zhang -- Urban health in developing countries / Siddharth Agarwal, Aradhana Srivastava, and Sanjeev Kumar -- A pervasive wireless knowledge management solution to address urban health inequalities with indigenous Australians / Nilmini Wickramasinghe, Indrit Troshani, and Steve Goldberg -- The development of a framework to evaluate the management of HIV/AIDS programmes in rural and urban South Africa / Rochelle Sassman ... [et al.] -- The potential of serious games for improving health and reducing urban health inequalities / M. Chris Gibbons -- Measures and metrics for KM and urban health. A scalable and viable strategy for managing organization : typology of intervening into complex healthcare environment for enhancing its continual development / Murako Saito -- Amplifying resonance in organizational learning process : knowledge sharing for overcoming cognitive barriers and for assuring positive action / Murako Saito -- Developing new urban health metrics to reduce the know-do gap in public health / Carlos Castillo-Salgado and Michael Christopher Gibbons -- Recommendations on evaluation and development of useful metrics for urban health / Carlos Castillo-Salgado and M. Chris Gibbons -- Making sense of urban health knowledge / Rajeev K. Bali ... [et al.].

Introduction to a conversation /Jeff Malpas and Norelle Lickiss --Human dignity and human worth /Daniel P. Sulmasy --Human dignity and human being /Jeff Malpas --On human dignity: fragments of an exploration /Norelle Lickiss --Two conceptions of dignity : honour and self-determination /Andrew Brennan and Y.S. Lo --Human dignity and charity /Rosalind Hursthouse --Human dignity: functions and meanings /Doron Shultziner --A brief history of human dignity: idea and application /Milton Lewis --A Journey towards understanding: true and false dignity /Christina Mason --The question of human dignity: doubts and loves and a whisper from where the ruined house once stood /Veronica Brady --Human dignity: a borderline heretical response /Stuart Blackler --Giving the past its dignity /Greg Dening --Dignity and indignity /Nicholas Tarling --Human dignity and the law /Sir Guy Green --On the international legal aspects of human dignity /Don Chalmers and Ryuichi Ida --Doing justice to dignity in the criminal law /Julia Davis --Human dignity: the new phase in international law /Michael Tate --Dignity and health /Martin Tattersall --Human dignity : the perspective of a gynaecological oncologist /Neville F. Hacker --The social origins of dignity in medical care at the end of life /Nicholas Cristakis --Dying with dignity : the story reveals its meaning /Jack Coulehan.

Foreword / Philip Zimbardo -- Preface -- Introduction: Persuasion in the digital age -- Overview of captology -- The functional triad : computers in persuasive roles -- Computers as persuasive tools -- Computers as persuasive media : simulation -- Computers as persuasive social actors -- Credibility and computers -- Credibility and the World Wide Web -- Increasing persuasion through mobility and connectivity -- The ethics of persuasive technology -- Captology : looking forward -- Appendix: Summary of principles.

Overview of healthcare, disease, and disability / Jeffrey Kaye, Tracy Zitzelberger -- Computer science tools and techniques / Martha E. Pollack, Bart Peintner -- Pervasive computing in hospitals / Jakob E. Bardram, Heribert Baldus, Jesus Favela -- Pervasive computing in the home and community / Donald J. Patterson, Henry A. Kautz, Dieter Fox, Lin Liao -- Mobile and personal health and wellness management systems / Elina Mattila, Ilkka Korhonen, Niilo Saranummi --Sensors and wearable technologies for pervasive healthcare / Sungmee Park, Sundaresan Jayaraman -- Assistive technologies / Edmund LoPresti -- Human factors and usability of healthcare systems / Andre Kushniruk, Elizabeth Borycki -- Routes and requirements for realizing pervasive medical devices / Michael P. Craven -- User evaluation in pervasive healthcare / Tim Adlam, Roger Orpwood, Teresa Dunn -- The business of pervasive healthcare / Dadong Wan, Luis E. Taveras.

Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.

Importance of Radiotracers Other than FDG in Oncology / Luigi Mansi, Pier Francesco Rambaldi and Vincenzo Cuccurullo -- Considerations About PET Isotopes / Luigi Mansi, Vincenzo Cuccurullo and Pier Francesco Rambaldi -- Choline PET-CT / Mohsen Farsad, Vincenzo Allegri and Paolo Castellucci -- Methionine PET-CT / Cristina Nanni, Valentina Ambrosini and Stefano Fanti -- Fluoride PET-CT / Roland Hustinx and Catherine Beckers -- Tyrosine PET-CT / Mohsen Farsad and Gabriele Pöpperl -- Somatostatin Receptor PET-CT / Valentina Ambrosini, Paolo Castellucci, GianCarlo Montini and Stefano Fanti -- Acetate PET-CT / Mohsen Farsad, Franca Chierichetti and Stefano Fanti -- Thymidine PET-CT / Ken Herrmann and Andreas Buck -- Dopa PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga -- Imaging of Hypoxia with PET-CT / Tove J. Grönroos, Heikki Minn and Rodney J. Hicks -- Angiogenesis PET Using Radiolabeled RGD Peptides / Keon Wook Kang, Jae Min Jeong and Ambros J. Beer -- Hormonal Receptors PET-CT / Erik F. J. de Vries, Andor W. J. M. Glaudemans, Caroline P. Schröder and Geke A. P. Hospers -- HTP PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga.

Provides fundamental information to all clinicians interested in incorporating PET into their clinical practice and who are involved in the diagnosis, initial staging, and restaging of malignancy. Covers basic principles such as patient preparation, imaging interpretation, and reimbursement, to specific applications for oncologic, cardiac, and neurologic disorders.

Historical review of Peyronie's disease: de la Peyronie to Devine / Emre Akkus -- Epidemiology of Peyronie's disease / Ates Kadioglu and Oner Sanli -- Experimental models for the study of the cellular and molecular pathophysiology of Peyronie's disease / Nestor F. Gonzalez-Cadavid and Jacob Rajfer -- The clinical implications of basic science research in Peyronie's disease / John P. Mulhall -- Evaluation of the man with Peyronie's disease / Jason M. Greenfield and Laurence A. Levine -- Oral treatment of Peyronie's disease / Claudio Teloken, Tulio Graziottin, and Patrick E. Teloken -- Intralesional treatment of Peyronie's disease / Muammer Kendirci, Landon Trost, and Wayne J. G. Hellstrom -- Topical therapy: iontophoresis and electromotive drug administration / Savino M. Di Stasi ... [et al.] -- Topical therapy for Peyronie's disease: ultrasound, laser, gels/creams/solutions / Paul F. Engelhardt and Claus R. Riedl -- Combination nonsurgical therapy / Vincenzo Mirone -- Extracorporeal shockwave therapy in Peyronie's disease / Ekkehard W. Hauck and Wolfgang Weidner --The Nesbit and plication procedures for Peyronie's disease / David J. Ralph -- Penile plication using the 16-dot technique / Robert C. Dean and Tom F. Lue -- Penile straightening with tunica albuginea plication: TAP procedure / Laurence A. Levine -- Incisional corporoplasty for the correction of Peyronie's disease caused penile curvature / Daniel Yachia -- Peyronie's disease: surgical straightening with tunica plication and tunica transfer / Konstantinos Hatzimouratidis and Dimitrios G. Hatzichristou -- A review of plaque incision with focus on temporalis fascia grafts / Martin Gelbard -- Venous patch graft surgery for Peyronie's disease / Robert C. Dean and Tom F. Lue -- Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's disease / L. Dean Knoll -- Penile straightening with plaque incision or partial excision and human pericardial grafting technique / Laurence A. Levine -- Surgical straightening with tunica incision and grafting technique: single relaxing incision based on geometrical principles / Paulo H. Egydio -- Minimally invasive intracorporal incision of Peyronie's plaque / Anthony J. Bella and Gerald B. Brock -- Surgical straightening with penile prosthesis / Steven K. Wilson and Culley C. Carson, III.

Why learn chopping? / David F. Chang -- Horizontal chopping : principles and pearls / Randall J. Olson -- Vertical chopping : principles and pearls / Louis D. "Skip" Nichamin -- Comparing and integrating horizontal and vertical chopping / David F. Chang -- Transitioning to phaco chop : pearls and pitfalls / David F. Chang -- Understanding the phacodynamics of chopping / Barry S. Seibel -- Optimizing machine settings for chopping techniques / David F. Chang -- Optimizing the AMO sovereign for chopping / David F. Chang -- Optimizing the Alcon legacy for chopping / Barry S. Seibel -- Optimizing the Alcon infiniti for chopping / David F. Chang -- Optimizing the Bausch & Lomb millennium for chopping / Barry S. Seibel -- Strategies for the difficult capsulorrhexis / David F. Chang -- Pearls for hydrodissection and hydrodelineation / David F. Chang -- Phaco strategies for complicated cataracts / David F. Chang -- Posterior capsule rupture and vitreous loss : advanced approaches / Louis D. "Skip" Nichamin -- Strategies for managing posterior capsular rupture / David F. Chang -- Microphaco chop : rationale and technique / Randall J. Olson -- Bimanual phaco chop : fluidic strategies / David F. Chang -- Bimanual phaco chop for capsular or zonular defects / David F. Chang.

Avoiding problems with the phacoemulsification machine / William J. Fishkind -- Gas-forced infusion : the solution for surge / Sunita Agarwal -- Mastering the transition to phacoemulsification : avoiding nightmares / Samuel Boyd, Benjamin F. Boyd, Cristela F. Aleman -- Preventing complications using no anesthesia cataract surgery with the karate chop technique / Amar Agarwal -- Using safe horizontal chopping to prevent ruptures / L. Felipe Vejarano, Alejandro Tello -- Principles and paradigms of pediatric cataracts surgery and intraocular lens implantation / Suresh K. Pandey, M. Edward Wilson -- Subluxated cataracts and endocapsular rings / Athiya Agarwal -- Mature cataracts and dyes / Amar Agarwal -- Small pupil phacoemulsification / Amar Agarwal, Soosan Jacob -- Intraoperative floppy iris syndrome / David F. Chang -- Surgical approach to iris reconstruction for iris diaphragm deficiency or dysfunction / Christopher Khng ... [et al.] -- Posterior polar cataracts / Abhay R. Vasavada, Shetal M. Raj -- Combined cataract and glaucoma surgery / Amar Agarwal, Soosan Jacob -- Phacoemulsification and keratoplasty / Javier Mendicute ... [et al.] --Bimanual phacoemulsification : surgical technique / Amar Agarwal -- Microphakonit / Amar Agarwal -- Complications of bimanual phacoemulsification / Amar Agarwal, Mahipal Singh Sachdev, Clement K. Chan.Phacoemulsification for hyperopia and nanophthalmos / Amar Agarwal, R. Sujatha -- Cataract surgery in dry eye / Suresh K. Pandey, Brighu Swamy, Amar Agarwal -- Phacoemulsification in patients with uveitis / Jorge L. Alio, Herminio Negri -- Refractive cataract surgery / Pandelis Papadopoulos -- Complications of phacoemulsification / L. Felipe Vejarano, Alejandro Tello -- Iatrogenic descemetorhexis as a complication of phacoemulsification / Amar Agarwal ... [et al.] -- Posterior capsular rupture / L. Felipe Vejarano, Alejandro Tello -- Intraocular Lens Power calculation in complex cases / Benjamin F. Boyd, Samuel Boyd, Luis W. Lu -- Posterior capsule opacification / Suresh K. Pandey ... [et al.] -- Intraocular Lens opacification / Suresh K. Pandey, Liliana Werner, David J. Apple -- Managing dislocated lens fragments / Clement K. Chan -- Surgical management of the malpositioned intraocular implant /Clement K. Chan ... [et al.] -- Infectious endophthalmitis / Clement K. Chan, Steven G. Lin -- Cystoid macular edema / Soosan Jacob, Amar Agarwal --

Translational medicine: a paradigm shift in modern drug discovery and development: the role of biomarkers / Mark Day, J. Lynn Rutkowski, and Giora Z. Feuerstein -- Natural products in drug discovery: present status and perspectives / Gabriella Molinari -- Protein pharmaceuticals: discovery and preclinical development / Davinder S. Gill -- The role of nanobiotechnology in drug discovery / Kewal K. Jain -- Conotoxin venom peptide therapeutics / Richard J. Lewis -- Shark novel antigen receptors: the next generation of biologic therapeutics? / Caroline Barelle, Davinder Gill, and Keith Charlton -- Immune interventions of human diseases through toll-like receptors / Cevayir Coban, Ken J. Ishii, and Shizuo Akira -- Genome-based vaccine development: a short cut for the future / Danilo Gomes Moriel ... [et al.] -- The antigenome: from protein subunit vaccines to antibody treatments of bacterial infections? / Carmen Giefing, Eszter Nagy, and Alexander von Gabain -- HSV as a vector in vaccine development and gene therapy / Peggy Marconi ... [et al.] -- Virus-like particles as a vaccine delivery system: myths and facts / Polly Roy and Rob Noad -- Applications of bacterial ghosts in biomedicine / Petra Lubitz, Ulrike Beate Mayr, and Werner Lubitz -- Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design / Thomas Ebensen and Carlos A. Guzmøn -- Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS / Aurelio Cafaro ... [et al.] -- New strategies to overcome the drawbacks of currently available flu vaccines / Epifanio Fichera ... [et al.].

Introduction to experimental design -- Comparison of mean values -- Nonparametric methods -- Regression and correlation -- Multivariate methods -- Factorial design of experiments -- Response-surface methodology -- Model-dependent optimization -- Sequential methods and model-independent optimization -- Experimental designs for mixtures -- Artificial neural networks and experimental design.

Strategic project management at the project level / Tony Kennedy -- Strategic project management at the portfolio level / Kevin Bilyard and Des Markland -- Project planning : from basic concepts to systems application / Carl A. Kutzbach, Carole Strong, and Sylvia Walker -- Project management of chemical, analytical, and formulation development / Dieter Krimmer -- Project management in exclusive synthesis / Lukas M.J. von Hippel -- Clinical trials--can they be project managed? / Les Rose -- Regulatory project management / Nicholas Wells -- Teams / Ralph White -- Project management and outsourcing drug development / Jon Court and Mark Fowler -- The project management function / Tony Kennedy.

Statistics in drug development by Christy Chuang-Stein and Ralph D'Agostino -- Modern classification methods for drug discovery by Kjell Johnson and William Rayens -- Model building techniques in drug discovery by Kimberly Crimin and Thomas Vidmar -- Statistical considerations in analytical method validation by Bruno Boulanger, Viswanath Devanaryan, Walthère Dewé, and Wendell Smith -- Some statistical considerations in nonclinical safety assessment by Wherly Hoffman, Cindy Lee, Alan Chiang, Kevin Guo, and Daniel Ness -- Nonparametric methods in pharmaceutical statistics by Paul Juneau -- Optimal design of experiments in pharmaceutical applications by Valerii Fedorov, Robert Gagnon, Sergei Leonov, and Yuehui Wu -- Analysis of human pharmacokinetic data by Scott Patterson and Brian Smith -- Allocation in randomized clinical trials by Olga Kuznetsova and Anastasia Ivanova -- Sample-size analysis for traditional hypothesis testing: concepts and issues by Ralph G. O'Brien and John Castelloe -- Design and analysis of dose-ranging clinical studies by Alex Dmitrienko, Kathleen Fritsch, Janson Hsu, and Stephen Ruberg -- Analysis of incomplete data by Geert Molenberghs, Caroline Beunckens, Herbert Thijs, Ivy Jansen, Geert Verbeke, Michael Kenward, and Kristen Van Steen -- Reliability and validity: Assessing the psychometric properties of rating scales by Douglas Faries and Ilker Yalcin -- Decision analysis in drug development by Carl-Fredrik Burman, Andy Grieve, and Stephen Senn.

Principles of Cancer Treatment / William G. Newman and Fiona H. Blackhall -- Clinical Pharmacology and Anticancer Drugs / Cristina Rodríguez-Antona and Julia Kirchheiner -- Principles of Genetics and Pharmacogenetics / William G. Newman -- Pharmacogenetics in the Management of Breast Cancer / Sacha J. Howell -- Pharmacogenetics in Colorectal Cancer / Roberta Ferraldeschi -- Pharmacogenetics in Lung Cancer / Fiona Blackhall -- Pharmacogenetics and Cancer Treatment in Children / P. Kellie Turner and Gareth J. Veal -- Pharmacogenetics in Palliative Care / Andrew A. Somogyi -- Genetic Predictors of Normal Tissue Response to Radiotherapy / Catharine M.L. West, Gillian C. Barnett, Alison M. Dunning, Rebecca M. Elliott and Neil G. Burnet -- Cancer Pharmacogenetics in Industry / Mireille Cantarini -- Ethical Issues in Pharmacogenetics / Tara Clancy -- Economics of Cancer Pharmacogenetics / Katherine Payne -- Future Advances in Cancer Pharmacogenomics / William G. Newman.

Challenges, opportunities, and evolving landscapes in pharmacogenomics and personalized medicine : an industry perspective / Nadine Cohen and Theresa Frangiosa -- Implementation of pharmacogenomic sample collection in clinical trials / Deborah Sokol Ricci and Monique Franc -- Pharmacogenomics : the regulatory environment and labeling implications / Myong-Jin Kim ... [et al.] -- Applications of pharmacogenomics in drug discovery / Duncan McHale -- Applications of pharmacogenomics in clinical trials / Monique Franc -- Pharmacogenomics applications in drug metabolism : from genotyping to drug label-challenges? / Ann K. Daly -- The genetics of adverse drug reactions : promises and problems / Martin Armstrong -- Strategies and resources for marker selection and genotyping in genetic association studies / Nicole Soranzo, Dong-Jing Fu, and Qingqin S. Li -- Study design and statistical issues in pharmacogenetics research : from candidate genes to genome-wide screens / Nicholas J. Schork, Nathalie Malo, and Eric J. Topol -- Holy SNP, Batman! / Reyna Favis -- Predictive biomarker classifiers in the design of pivotal clinical trials / Richard Simon -- Translation of biomarkers into clinical utility / William L. Trepicchio and George Mulligan -- Pharmacogenomic study feasibility assessment and pharmaceutical business decision-making / Monique Franc and Theresa Frangiosa -- Co-development of drugs and pharmacogenomics-based diagnostics in oncology / Jeffrey S. Ross -- Pharmacogenomics applications in epilepsy / Chantal Depondt -- Pharmacogenomics in Alzheimer's disease / Ramón Cacabelos -- Pharmacogenomics applications in psychiatric disorders / Todd Lencz and Anil K. Malhotra -- Pharmacogenomics in HIV disease / Amalio Telenti -- Pharmacogenomics and cardiovascular drugs / Gérard Siest ... [et al.] -- Pharmacogenomic applications in children / Susan F.A. Grant and Hakon Hakonarson -- Pharmacogenomics of rare and monogenic disorders / Paul D. Maher.

Historical aspects of pharmacogenetics / Werner Kalow -- Pharmacogenomics and the promise of personalized medicine / Vural Ozdemir and Bernard Lerer -- Pharmacogenetics of drug metabolism: two clinically important polymorphic enzymes, CYP2D6 and TPMT / Georgios Panagiotidis and Leif Bertilsson -- Receptors / Wendell W. Weber -- Pharmacogenetics of drug transporters / Catia Marzolini, Rommel G. Tirona, and Richard B. Kim -- Variability in induction of human drug metabolizing enzymes / Allan B. Okey -- Pharmacogenetics and cardiac ion channels / Dan M. Roden -- Interethnic differences in drug response / Werner Kalow -- Clinical perspectives / Urs A. Meyer and David A. Flockhart -- Regulatory perspectives on pharmacogenomics / Lawrence J. Lesko and Janet Woodcock -- Tools of the trade: the technologies and challenges of pharmacogenetics / Glenn A. Miller -- Technologies for the analysis of single nucleotide polymorphisms - an overview / Denis M. Grant -- Molecular diagnostics / Tracy L. Stockley and Peter N. Ray --

ch. 1. Physicochemistry -- ch. 2. Pharmacokinetics -- ch. 3. Absorption -- ch. 4. Distribution -- ch. 5. Clearance -- ch. 6 Renal clearance -- ch. 7. Metabolic (hepatic) clearance -- ch. 8. Toxicity -- ch. 9. Inter-species -- ch. 10. High(er) throughput ADME studies.

SECTION I. Basic Principles -- Chapter 1. Basic Principles / Ronald D. Schoenwald -- SECTION II. Industrial and Regulatory Applications -- Chapter 2. PK/PD Approach / Honghui Zhou -- Chapter 3. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development / Nishit B. Modi -- Chapter 4. Phase I, II, and III FDA Submissions / Mark G. Eller -- Chapter 5. Bioavailability and Bioequivalence / Veneeta Tandon -- SECTION III. Clinical Applications -- Chapter 6. General Approaches to Clinical Pharmacokinetic Monitoring / Ronald A. Herman -- Chapter 7. Aminoglycosides and Other Antibiotics / Michael E. Klepser and Erika J. Ernst -- Chapter 8. Cardiovascular Agents / John M. Dopp and Bradley G. Phillips -- Chapter 9. Psychotropic Agents / Paul J. Perry -- Chapter 10. Theophylline / Bernd Meibohm -- Chapter 11. Anticonvulsant Agents / Gail D. Anderson -- SECTION IV. Research Applications -- Chapter 12. Classical Modeling / David W A. Bourne -- Chapter 13. Noncompartmental Modeling: An Overview / Ronald A. Herman -- Chapter 14. Physiologically Based Pharmacokinetic Models / James M. Gallo -- Chapter 15. Population Pharmacokinetics / Jeffrey S. Barrett -- Chapter 16. The Linear Systems Approach / Peter Veng-Pedersen -- Index.

Pharmacokinetics and pharmacodynamics of injected and inhaled drugs -- Inhaled anesthetics -- Opioid agonists and antagonists -- Barbiturates -- Benzodiazepines -- Nonbarbiturate intravenous anesthetic drugs -- Local anesthetics -- Neuromuscular-blocking drugs -- Anticholinesterase drugs and cholinergic agonists -- Anticholinergic drugs -- Cyclooxygenase-2 inhibitors and nonspecific nonsteroidal antiinflammatory drugs -- Sympathomimetics -- Digitalis and related drugs -- Alpha- and beta-adrenergic receptor antagonists -- Antihypertensive drugs -- Peripheral vasodilators, nitric oxide, and nitrovasodilators -- Cardiac antidysrhythmic drugs -- Calcium-channel blockers -- Drugs used for psychopharmacologic therapy -- Prostaglandins -- Histamine and histamine receptor-antagonists -- Serotonin, plasma kinins, and renin -- Hormones as drugs -- Insulin and oral hypoglycemics -- Diuretics -- Antacids and gastrointestinal prokinetics -- Anticoagulants -- Antimicrobials -- Chemotherapeutic drugs -- Antiepileptic drugs -- Antiepileptic drugs -- Drugs used for treatment of parkinson disease -- Drug treatment of lipid disorders -- Central nervous system stimulants and muscle relaxants -- Vitamins, dietary supplements, and herbal remedies -- Minerals and electrolytes -- Blood components, substitutes and hemostatic drugs -- Enteral and parenteral nutrition -- Antiseptics and disinfectants -- Cell structure and function -- Body fluids -- Central nervous system -- Thermoregulation -- Autonomic nervous system -- Pain -- Systemic circulation -- Microcirculation and lymphatics -- Pulmonary circulation -- Heart -- The electrocardiogram and analysis of cardiac dysrhythmias -- The lungs -- Pulmonary gas exchange and blood transport of gases -- Acid-base balance -- Endocrine system -- Kidneys -- Liver and gastrointestinal tract -- Skeletal and smooth muscle -- Erythrocytes and leukocytes -- Hemostasis and blood coagulation -- Metabolism of nutrients -- Physiology of the newborn and elderly.

Pharmacology -- Pharmacokinetic Principles -- Introduction to Specialist Therapeutics.

What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.

General principles -- The peripheral nervous systems: autonomic and somatic -- The central nervous system -- The cardiovascular system -- The renal system and diuretics -- The respiratory system: asthma and COPD -- Local control substances: autacoids and drugs for inflammatory processes -- The gastrointestinal system and nutrition -- The endocrine system, uterine stimulants, and relaxants -- Anti-infectives -- Cancer chemotherapy and immunosuppressants -- Toxicology.

General Principles of Pharmacology -- The Peripheral Nervous System: Autonomic and Somatic Nervous System Pharmacology -- Central Nervous System Pharmacology -- Cardiovascular Pharmacology -- Renal System and Diuretics Pharmacology -- Respiratory System Pharmacology: Asthma and COPD -- Autacoids and Anti-Inflammatory Pharmacology -- Gastrointestinal and Urinary Tract Pharmacology, Nutrition (Vitamins) -- Endocrine Pharmacology, Uterine Stimulants and Relaxants -- Antimicrobial and Antiviral Pharmacology -- Cancer and Immune System Pharmacology -- Toxicology, Bioterrorism, and Chemical Warfare Agents.

Providing evidence of therapeutic benefit in clinical drug development / Steven Kesten and Theodore J. Witek -- Use of expiratory airflows and lung volumes to assess outcomes in COPD / Gary T. Ferguson -- Exercise testing / Denis E. O'Donnell and Katherine A. Webb -- Sleep-related breathing disturbances in COPD / Walter T. McNicholas -- Airway and alveolar determinants of airflow limitation in COPD / Noe Zamel -- Gas exchange / Antoni Ferrer, Joan Albert Barberá, and Roberto Rodriguez-Roisin -- Genetics of COPD / Jian-Quing He, Ikuma Kasuga, and Peter D. Paré -- Dyspnea / Donald A. Mahler -- Exacerbations of COPD / Jadwiga A. Wedzicha -- Health status measurement in COPD / Paul W. Jones -- Health resource utilization / Mitchell Friedman -- Anticholinergics / Peter J. Barnes -- β-adrenergic receptor agonist bronchodilators in the treatment of COPD / Stephen I. Rennard -- Theophylline and phosphodiesterase inhibitors in COPD / Alicia R. ZuWallack and Richard L. ZuWallack -- Corticosteroids in COPD / Mario Cazzola, Maria Gabriella Matera, and Romain Pauwels -- Antioxidants and protease inhibitors / Mario Cazzola and Maria Gabriella Matera -- An integrated approach to the pharmacological therapy of COPD / Bartolome R. Celli.

Pharmacoepidemiology of diabetes -- New definitions of diabetes: consequences -- The insulin resistance syndrome: concept and therapeutic approaches -- Medical emergencies-diabetic ketoacidosis and hyperosmolar hyperglycaemia -- Notes on the use of glucagon in type 1 diabetes -- Insulin and new insulin analogues, insulin pumps and inhaled insulin in type 1 diabetes -- Insulin and new insulin analogues with focus on type 2 diabetes -- The place of insulin secretagogues in the treatment of type 2 diabetes in the twenty-first century -- Metformin-from devil to angel -- The glitazones, lessons so far -- Antidiabetic combination therapy -- The incretin modulators-incretin mimetics (GLP-1 receptor agonists) and incretin enhancers (DPP-4 inhibitors) -- The role of alpha-glucosidase inhibitors (acarbose) -- Multifactorial intervention in type 2 diabetes -- Obesity and pharmacological treatment -- Management of diabetic dyslipidaemia -- Coronary intervention and ischemic cardioprotection in diabetic patients -- ACE-I and ARB and blood pressure lowering, including effect on renal disease. Treatment of advanced diabetic renal disease -- Aspirin and antiplatelet drugs in the prevention of cardiovascular complications of diabetes -- Glycosylation inhibitors, PKC inhibitors and related interventions against complications -- Diabetic foot ulcers -- Pharmacotherapy in diabetic neuropathy -- Pregnancy-pharmacological problems - Pharmacotherapy of diabetic retinopathy -- Pharmacotherapy in diabetic sexual dysfunction -- A bone perspective -- Achieving guideline control with new pharmacotherapies; albumin-binding by acylation of insulin and GLP-1 -- Pharmacotherapy of diabetes.

Principles of catecholamine biosynthesis, metabolism and release /Schulz, C., Eisenhofer, G.; Lehnert, H. (Magdeburg) --Photogenesis of pheochromocytoma /Isobe, K. ... [et al.] --Genetic basis of pheochromocytoma /Gimm, O.; Koch, C.A. ... [et al.] --Clinical presentation (symptoms and signs) of sporadic and familial chromaffin cell tumours (phaeochromocytomas and paragangliomas) /Kaltsas, G.A.; Papadogias, D.; Grossman, A.B. (London) --Biochemical diagnosis of pheochromocytoma /Eisenhofer, G. (Bethesda, Md.); Lenders, J.W.M. (Nijmegen); Pacak, K. (Bethesda, Md.) --Diagnostic imaging of pheochromocytoma /Pacak, K.; Eisenhofer, G.; Ilias, I. (Bethesda, Md.) --Preoperative and surgical therapy in sporadic and familial pheochromocytoma /Brauckhoff, M; Gimm, O.; Dralle, H. (Halle) --Somatosatin receptors in pheochromocytoma /de Herder, W.W.; Hofland L.J. (Rotterdam) --Malignant pheochromocytoma /Lehnert, H.; Mundshenk, J. (Magdeburg); Hahn, K. (Munich).

This volume covers a wide range of conceptual, epistemological and methodological issues in the philosophy of science raised by reflection upon medical science and practice. Several chapters examine such general meta-scientific concepts as discovery, reduction, theories and models, causal inference and scientific realism as they apply to medicine or medical science in particular. Some discuss important concepts specific to medicine (diagnosis, health, disease, brain death). A topic such as evidence, for instance, is examined at a variety of levels, from social mechanisms for guiding evidence-based reasoning such as evidence-based medicine, consensus conferences, and clinical trials, to the more abstract analysis of experimentation, inference and uncertainty. Some chapters reflect on particular domains of medicine, including psychiatry, public health, and nursing. The contributions span a broad range of detailed cases from the science and practice of medicine, as well as a broad range of intellectual approaches, from conceptual analysis to detailed examinations of particular scientific papers or historical episodes. Chapters view philosophy of medicine from quite different angles Considers substantive cases from both medical science and practice Chapters from a distinguished array of contributors.

Examining stem cell biology from a philosophy of science perspective, this book clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. The first chapters discuss what stem cells are, how experiments identify them, and why these two issues cannot be completely separated. The basic concepts, methods and structure of the field are set out, as well as key limitations and challenges. The second part of the book shows how rigorous explanations emerge from stem cell experiments, and compares these to other kinds of scientific explanation. Model organisms, the role of genes, and the significance of collaboration are also discussed. The last part of the book considers relations to systems biology and clinical medicine, arguing that both the mathematical models of the former, and ethical principles of the latter, are necessary for stem cell biology to deliver on its promises.

A high-resolution two dimensional gel- and pro-Q DPS-based proteomics workflow for phosphoprotein identification and quantitative profiling / Ganesh K. Agrawal and Jay J. Thelen -- Differential phosphoprotein labelling (DIPPL) using ³²P and ³³P / Aviva M. Tolkovsky and Andreas Wyttenbach -- Identification of oxidative stress-induced tyrosine phosphorylated proteins by immunoprecipitation and mass spectrometry / Ma Carmen Duran, Hong-Lin Chan, and John F. Timms -- Enrichment and characterization of phosphopeptides by immobilized metal affinity chromatography (IMAC) and mass spectrometry / Tine E. Thingholm and Ole N. Jensen -- The use of titanium dioxide micro-columns to selectively isolate phosphopeptides from proteolytic digests / Tine E. Thingholm and Martin R. Larsen -- Enrichment and separation of mono- and multiply phosphorylated peptides using sequential elution from IMAC prior to mass spectrometric analysis / Tine E. Thingholm , Ole N. Jensen, and Martin R. Larsen -- Use of stable isotope labeling by amino acids in cell culture (SILAC) for phophotyrosine protein identification and quantitation / Guoan Zhang and Thomas A. Neubert -- Hydrophilic interaction chromatography for fractionation and enrichment of the phosphoproteome / Dean E. McNulty and Roland S. Annan -- SILAC for global phosphoproteomic analysis / Genaro Pimienta, Raghothama Chaerkady, and Akhilesh Pandey -- Quantitative phospho-proteomics based on soluble nanopolymers / Anton Iliuk and W. Andy Tao -- Profiling the tyrosine phosphorylation state using SH2 domains / Kevin Dierck ... [et al.] -- An overview of the qualitative analysis of phosphoproteins by mass spectrometry / Philip R. Gafken -- The analysis of phosphoproteomes by selective labelling and advanced mass spectrometric techniques / Angela Amoresano ... [et al.] -- On-line liquid chromatography electron capture dissociation for the characterization of phosphorylation sites in proteins / Steve M.M. Sweet and Helen J. Cooper -- Quantification of protein phosphorylation by [mu]LC-ICP-MS / Ralf Krüger, Nico Zinn, and Wolf D. Lehmann -- Reverse-phase diagonal chromatography for phosphoproteome research / Kris Gevaert and Joël Vandekerckhove -- Chemical tagging strategies for mass spectrometry-based phospho-proteomics / Alexander Leitner and Wolfgang Lindner -- Antibody array platform to monitor protein tyrosine phosphorylation in mammalian cells / Alicia S. Chung and Y. Eugene Chin -- Protein tyrosine kinase characterization based on fully automated synthesis of (phospho)peptide arrays in microplates / W. Carl Saxinger -- Kinome profiling using peptide arrays in eukaryotic cells / Kaushal Parikh, Maikel P. Peppelenbosch, and Tita Ritsema -- ProMoST : a tool for calculating the pI and molecular mass of phosphorylated and modified proteins on two-dimensional gels / Brian D. Halligan -- Kinase-specific preiction of protein phosphorylation sites / Martin L. Miller and Nikolaj Blom -- Reconstructing regulatory kinase pathways from phosphopeptide data : a bioinformatics approach / Lawrence G. Puente, Robin E.C. Lee, and Lynn A. Megeney.

Purification of PDE6 isozymes from mammalian retina / Dana C. Pentia ... [et al.] -- Cyclic guanosine 5'-monophosphate binding to the regulatory GAF domains of photoreceptor phosphodiesterase / Rick H. Cote -- Renaturation of the catalytic domain of PDE4A expressed in escherichia coli as inclusion bodies / Wito Richter, Thomas Hermsdorf, and Dietrich Dettmer -- Determining the subunit structure of phosphodiesterases using gel filtration and sucrose density gradient centrifugation / Wito Richter -- Crystallization of cyclic nucleotide phosphodiesterases / Hengming Ke, Qing Huai, and Robert X. Xu -- Generation of PDE4 knockout mice by gene targeting / S.-L. Catherine Jin, Anne M. Latour, and Marco Conti -- Immunoprecipitating PDE2 phosphorylated and inactivated by an associated protein kinase / J. Kelley Bentley -- Investigation of extracellular signal-regulated kinase 2 mitogen-actived protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases / Elaine V. Hills, Miles D. Houslay, and George S. Baillie --Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11 / James L. Weeks ... [et al.] -- Analysis of dimerization determinants of the PDE6 catalytic subunits / Khakim G. Muradov, Kimberley K. Boyd, and Nikolai O. Artemyev -- Interaction between catalytic and inhibitory subunits of PDE6 / Nikolai O. Artemyev -- Purification, reconstitution on lipid vesciles and assays of PDE6 and its activator G protein, transducin -- Theodore G. Wensel, Feng He, and Justine A. Malinski.Study of cyclic adenosine monophosphate microdomains in cells / Marco Mongillo ... [et al.] -- High-resolution measurements of cyclic adenosine monophosphate signals in 3D microdomains / Jeffrey W. Karpen and Thomas C. Rich -- Cygnets : in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP / Akira Honda ... [et al.] -- High-throughput screening of phosphodiesterase activity in living cells / Thomas C. Rich and Jeffrey W. Karpen -- Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts / Thèrése Keravis, Rima Thaseldar-Roumié, and Claire Lugnier -- Localization of the cyclic guanosine 3', 5'-monophosphate-hydrolysing phosphodiesterase type 9 in rat brain by nonradioactive in situ hybridization / Wilma C.G. Van Staveren and Marjanne Markerink-Van Ittersum -- Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells / Chen Yan -- Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B / Faiyaz Ahmad ... [et al.] -- Identification of promoter elements in the 5'-flanking region of the murine cyclic nucleotide phosphodiesterase 3B gene / Hanguan Liu ... [et al.] --

Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).

Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).

The Phosphatidylinositol 4-Kinases: Don't Call it a Comeback /Shane Minogue and Mark G. Waugh --PIP Kinases from the Cell Membrane to the Nucleus /Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan and Richard Anderson --The Phospholipase C Isozymes and Their Regulation /Aurelie Gresset, John Sondek and T. Kendall Harden --Phosphoinositide 3-Kinases-A Historical Perspective /Alex Toker --PI3Ks-Drug Targets in Inflammation and Cancer /Matthias Wymann --Phosphoinositide 3-Kinases in Health and Disease /Alessandra Ghigo, Fulvio Morello, Alessia Perino and Emilio Hirsch --Phosphoinositide Phosphatases: Just as Important as the Kinases /Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic and Christina A. Mitchell --The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease /Nicholas R. Leslie, Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal and Clare G. Fedele, et al.

O2-Sensitive Probes Based on Phosphorescent Metalloporphyrins /Ruslan I. Dmitriev and Dmitri B. Papkovsky --O2 Analysis on a Fluorescence Spectrometer or Plate Reader /Alexander V. Zhdanov, James Hynes, Ruslan I. Dmitriev and Dmitri B. Papkovsky --O2 Imaging in Biological Specimens /Andreas Fercher, Alexander V. Zhdanov and Dmitri B. Papkovsky.

Part 1. Propagation of light -- ch. 1. Overview -- ch. 2. Review of optics -- ch. 3. Planar waveguides -- ch. 4. Cylindrical waveguides -- ch. 5. Losses in optical fibers -- ch. 6. Dispersion in optical fibers -- ch. 7. Fiber connections and diagnostics -- ch. 8. Photonic crystal optics -- ch. 9. Nonlinear optics -- Part 2. Generation and Detection of Light -- ch. 10. Review of semiconductor physics -- ch. 11. Light sources -- ch. 12. Light source to waveguide coupling efficiency -- ch. 13. Optical detectors -- ch. 14. Photodiode detectors -- Part 3. Laser light -- ch. 15. Lasers and coherent light -- ch. 16. Optical resonators -- ch. 17. Guassian beam optics -- ch. 18. Stimulated emission and optical gain -- ch. 19. Optical amplifiers -- ch. 20. Laser oscillation -- ch. 21. CW laser characteristics -- ch. 22. Pulsed lasers -- ch. 23. Survey of laser types -- Part 4. Light-based communications -- ch. 24. Optical communications -- Appendix A. Solid angle and the brightness theorem -- Appendix B. Fourier synthesis and the uncertainty relation.

Assay of photoinhibition of photosystem II and protease activity / Yasusi Yamamoto ... [et al.] -- Thermoluminescence: a technique for probing photosystem II / Prafullachandra V. Sane -- Detection of free radicals and reactive oxygen species / Éva Hideg -- Stabilization of photosynthetic materials / Régis Rouillon, Pierre Euzet, and Robert Carpentier -- Determination of phosphoproteins in higher plant thylakoids / Eva-Mari Aro, Anne Rokka, and Alexander V. Vener -- Identifying photoprotection mutants in Arabidopsis thaliana / Jan Bart Rossel, Abby Cuttriss, and Barry J. Pogson -- A simple method for chloroplast transformation in Chlamydomonas reinhardtii / Velupillai M. Ramesh, Scott E. Bingham, and Andrew N. Webber -- The Construction of gene knockouts in the Cyanobacterium Synechocystis sp. PCC 6803 / Julian J. Eaton-Rye -- Gene inactivation in the cyanobacterium Synechococcus sp. PCC 7002 and the green sulfur bacterium Chlorobium tepidum using in vitro-made DNA constructs and natural transformation / Niels-Ulrik Frigaard, Yumiko Sakuragi, and Donald A. Bryant.Fractionation of thylakoid membranes into grana and stroma thylakoids / Juan Cuello and María José Quiles -- Isolation of photosystem I particles from spinach / Tetsuo Hiyama -- Rapid isolation and purification of photosystem I chlorophyll-binding protein from Chlamydomonas reinhardtii / Velupillai M. Ramesh and Andrew N. Webber -- Isolation of photosystem II-enriched membranes and the oxygen-evolving complex subunit proteins from higher plants / Yasusi Yamamoto, Shinsuke Sakuma, and Jian-Ren Shen -- Isolation of functional photosystem II core particles from the Cyanobacterium synechocystis sp. PCC 6803 / Dmitrii Vavilin -- Isolation of photosystem I reaction center preparation from spinach / Tetsuo Hiyama -- Isolation of photosystem II reaction center complexes from plants -- Michael Seibert, Inmaculada Yruela, and Rafael Picorel -- Isolation of photosystem I reaction center subunit polypeptides from spinach / Tetsuo Hiyama -- Purification and crystallization of the cytochrome b6f complex in oxygenic photosynthesis / Huamin Zhang and William A. Cramer -- Purification of plastocyanin and cytochrome C6 from plants, green algae, and cyanobacteria / José A. Navarro, Manuel Hervás, and Miguel A. De la Rosa --Preparation of native and recombinant light-harvesting chlorophyll-a/b complex / Wolfgang Rühle and Harald Paulsen -- Isolation and characterization of lamellar aggregates of LHCII and LHCII-lipid macro-assemblies with light-inducible structural transitions / Ilian Simidjiev, Zsuzsanna Vácrkonyi, and Gyozo Garab -- Separation, purification and characterization of polypeptide composition of subcomplexes of the main light-harvesting chlorophyll a/b-protein complex of photosystem II / Grzegorz Jackowski -- Isolation of CP43 and CP47 photosystem II proximal antenna complexes from plants / Rafael Picorel, Miguel Alfonso, and Michael Seibert -- The determination and quantification of photosynthetic pigments by reverse phase high-performance liquid chromatography, thin-layer chromatography, and spectroscopy / Tessa Pocock, Marianna Król, and Norman P. A. Huner -- Isolation and identification of chloroplast lipids / Norihiro Sato and Mikio Tsuzuki -- DNA adducts with chlorophyll and chlorophyllin as antimutagenic agents: synthesis, stability, and structural features / Heidar-Ali Tajmir-Riahi, Jean-Francois Neault, and Stravoula Diamantoglou -- Incorporation and analysis of LHCII in model systems / Wieslaw I. Gruszecki -- Photosystem II reconstitution into proteoliposomes: structure-function characterization / Mário Fragata -- Extraction of the functional manganese and calcium from photosystem II / Joel Freeman, Garth Hendry, and Tom Wydrzynski --

From gene-scale to genome-scale phylogenetics : the data flood in, but the challenges remain / Antonis Rokas and Stylianos Chatzimanolis -- Phylogenomic analysis of chromosome sorting and painting / Roscoe Stanyon and Gary Stone -- FISH for mapping single copy genes / Terje Raudsepp and Bhanu P. Chowdhary -- Construction of radiation hybrid panels / John E. Page and William J. Murphy -- Survey sequencing and radiation hybrid mapping to construct comparative maps / Christophe Hitte ... [et al.] -- Construction of high-resolution comparative maps in mammals using BAC-end sequences / Denis M. Larkin and Harris A. Lewin -- Amniote phylogenomics : testing evolutionary hypotheses with BAC library scanning and targeted clone analysis of large-scale sequences from reptiles / Andrew M. Shedlock, Daniel E. Janes, and Scott V. Edwards -- Comparative physical mapping : universal overgo hybridization probe design and BAC library hybridization / James W. Thomas -- Phylogenomic resources at the UCSC Genome Browser / Kate Rosenbloom ... [et al.] -- Computational tools for the analysis of rearrangements in mammalian genomes / Glenn Tesler and Guillaume Bourque -- Computational reconstruction of ancestral DNA sequences / Mathieu Blanchette ... [et al.] -- Sequencing and phylogenomic analysis of whole mitochondrial genomes of animals / Rafael Zardoya and Mónica Suárez -- Retroposons : genetic footrpints on the evolutionary paths of life / Hidenori Nishihara and Norihiro Okada -- LINE-1 elements : analysis by FISH and nucleotide sequences / Paul D. Waters ... [et al.] -- Identification of cryptic sex chromosomes and isolation of X- and Y-borne genes / Paul D. Waters ... [et al.]

Vascular Deficiency --Disuse --Infection --Tumor --Metabolic --Neural --Cold Injury (Frostbite) --Heat Injury (Burns) --Electric Injuries --Compression --Distraction --Stress --Irradiation --Light Waves --Sound Waves --Shock Waves --Atmospheric Pressure --Oxygen --Developmental --Surgical --Unknown.

Promotes value of lifelong moderate exercise.

Epidemiology of overweight/obesity and cancer risk -- Epidemiology of physical activity and cancer risk -- Energetics and cancer: exploring a road less traveled -- Calorie restriction, exercise, and colon cancer prevention: a mechanistic perspective -- Mechanisms linking obesity to cancer risk -- Mechanisms underlying the effects of physical activity on cancer -- Physical activity, weight control, and cancer prognosis.

pt. 1. Principles of biophysical inquiry -- pt. 2. Foundations -- pt. 3. Building a model of biomolecular structure -- pt. 4. Function and action biological state space -- pt. 5. Methods for the measuring structure and function -- pt. 6. Physical constants.

Ch. 1. Introduction, p. 1-18 -- Ch. 2. Syntheses of Macromolecular Compounds, p. 19-51 -- Ch. 3. Distribution of Molecular Weight, p. 52-66 -- Ch. 4. Macromolecular Thermodynamics, p. 67-95 -- Ch. 5. Chain Configurations, p. 96-126 -- Ch. 6. Liquid Crystals, p. 127-149 -- Ch. 7. Rubber Elasticity, p. 150-164 -- Ch. 8. Viscosity and Viscoelasticity, p. 165-197 -- Ch. 9. Osmotic Pressure, p. 198-222 -- Ch. 10. Diffusion, p. 223-242 -- Ch. 11. Sedimentation, p. 243-266 -- Ch. 12. Optical Rotatory Dispersion and Circular Dichroism, p. 267-283 -- Ch. 13. High-Performance Liquid Chromatography and Electrophoresis, p. 284-319 -- Ch. 14. Light Scattering, p. 320-347 -- Ch. 15. Fourier Series, p. 348-370 -- Ch. 16. Small-Angle X-Ray Scattering, Neutron Scattering, and Laser Light Scattering, p. 371-398 -- Ch. 17. Electronic and Infrared Spectroscopy, p. 399-435 -- Ch. 18. Protein Molecules, p. 436-454 -- Ch. 19. Nuclear Magnetic Resonance, p. 455-496 -- Ch. 20. X-Ray Crystallography, p. 497-534.

Chest inspection, palpation, and percussion / Salvatore Mangione -- Lung auscultation / Salvatore Mangione -- The abdomen / Salvatore Mangione -- Male genitalia, hernias, and rectal exam / Salvatore Mangione -- Pelvic examination / Salvatore Mangione -- Lymph nodes / Salvatore Mangione -- Neurologic examination / Enrica Arnaudo and Michael D. Kim -- Bedside diagnosis of coma / Salvatore Mangione -- The musculoskeletal system / Salvatore Mangione -- The extremities / Salvatore Mangione.Top 100 secrets -- General appearance, facies, and body habitus / Salvatore Mangione -- Vital signs / Salvatore Mangione -- The skin / Salvatore Mangione -- Eye examination / Salvatore Mangione -- The ear / Salvatore Mangione -- Nose and mouth / Salvatore Mangione -- Neck examination / Salvatore Mangione -- Thyroid gland / Salvatore Mangione -- Breast examination / Salvatore Mangione -- Cardiovascular physical exam / Salvatore Mangione -- Heart sounds and extra-sounds / Salvatore Mangione -- Cardiac auscultation murmurs / Salvatore Mangione --

General inspection and vital signs -- Dermatology-- Head, ears, eyes nose, and throat -- Pulmonary/critical care -- Cardiovascular System -- Gastrointestinal system -- Renal and genitourinary system -- Endocrinology -- Hematology and oncology -- Rheumatology -- Musculoskeletal system -- Neurology -- Geriatrics -- Infectious diseases -- Obstetrics and gynecology -- Pediatrics and neonatology -- Bonus chapter: The ten toughest physical diagnosis question ever written -- High yield facts.

Part I: An introduction to aging -- Part II: Physical changes in structure, capacity, and endurance -- Part III: Motor coordination, motor control, and skill -- Part IV: Physical-psychosocial relationships -- Part V: Physical performance and achievement.

The physiatric history and physical examination -- Examination of the pediatric patient -- Adult neurogenic communication disorders -- Psychological assessment and intervention in rehabilitation -- Gait analysis: technology and clinical applications -- Impairment rating and disability determination -- Neurologic and musculoskeletal imaging studies -- Quality and outcome measures for medical rehabilitation -- Electrodiagnostic medicine I: fundamental principles -- Electrodiagnostic medicine II: clinical evaluation and findings -- Electrodiagnostic medicine III: case studies -- Rehabilitation and prosthetic restoration in upper limb amputation -- Rehabilitation and prosthetic restoration in lower limb amputation -- Upper limb orthotic devices -- Lower limb orthotic devices -- Spinal orthoses -- Wheelchairs and seating systems -- Therapeutic exercise -- Manipulation, traction, and massage -- Physical agent modalities -- Electrical stimulation -- Integrative medicine in rehabilitation -- Computer assistive devices and environmental controls -- Peripheral joint and soft tissue injection techniques -- Spinal injection techniques -- Achieving functional independence -- Rehabilitation of patients with swallowing disorders -- Management of bladder dysfunction -- Neurogenic bowel: dysfunction and rehabilitation -- Spasticity management --Sexuality dysfunction and disability -- Prevention and management of chronic wounds -- Cardiac rehabilitation -- Pulmonary rehabilitation -- Employment of persons with disabilities -- Rheumatic diseases -- Common neck problems -- Musculoskeletal disorders of the upper limb -- Musculoskeletal disorders of the lower limb -- Low back pain -- Osteoporosis -- Chronic pain -- Muscle pain syndromes -- Sports medicine -- Occupational rehabilitation -- Motor neuron diseases -- Rehabilitation of patients with neuropathies -- Myopathic disorders -- Traumatic brain injury -- Stroke syndromes -- Degenerative movement disorders of the central nervous system -- Multiple sclerosis -- Cerebral palsy -- Myelominingocele and other spinal dysraphisms -- Spinal cord injury -- Lower limb peripheral vascular disease -- Cancer rehabilitation -- Burn rehabilitation -- Geriatric rehabilitation -- Transplantation of organs: rehabilitation to maximize outcomes -- International physical medicine and rehabilitation.

pt. 1. Getting started as physician-scientist. -- Beginnings -- Is a physician-scientist career right for you? -- Training as a physician-scientist -- pt. 2. Launching your career as a physician-scientist. -- Getting a job -- Appointments, tenure, promotions, and sabbaticals -- Teaching -- Administration -- Research -- pt. 3. Building your career as a physician-scientist. -- Writing -- Publishing -- Grants -- Grantsmanship -- Peer review of grant applications -- Managing your team, time, and money -- Mentorship -- Lectures and presentations -- Relations with industry -- pt. 4. Parting words of advice : putting it all together. -- Balancing research, clinical activities, and family life -- Improving the physician-scientist pathway -- Concluding remarks.

Goals for your investment returns -- The magnificence of compound interest -- Arrogance, ego, and greed -- The mark -- It's not much, I can afford to lose it -- Define specific goals -- Thrift -- Invest in what you know -- Make your own investment decisions -- Documents required for financial security -- The importance of relationships -- Paying daily bills -- Your home -- Funding your children's education -- Insurance -- Funding retirement -- Who can you trust -- The malevolence of debt -- The perniciousness of fees -- Tips : real opportunities or useless information -- Areas where caution is essential or that should be completely avoided -- Yes or no -- Dealing with bankers -- Asset allocation and diversification -- How to identify real investment opportunities -- When to buy -- When to sell -- Stocks, bonds, and mutual funds -- Real estate other than your home -- Other types of investments -- Obtaining investment information -- Investment strategies of the pros -- Some miscellaneous tidbits of advice.

" ... explains and describes the applications of philosophy, logic and critical thinking in particular, in medicine."--Back cover.

Introduction. False dichotomy versus genuine choice : the argument over physician-assisted dying / Margaret P. Battin, Timothy E. Quill -- pt. 1. Perspectives on mercy, nonabandonment, autonomy, and choice -- 1. The quality of mercy / Marcia Angell -- 2. Nonabandonment : a central obligation for physicians / Timothy E. Quill, Christine K. Cassel -- 3. The role of autonomy in choosing physician aid in dying / Thomas Preston, Martin Gunderson, David J. Mayo -- 4. Disability and physician-assisted dying / Andrew I. Batavia -- 5. When suffering patients seek death / Eric J. Cassell -- pt. 2. Clinical, philosophical, and religious issues about the ending of life -- 6.Why do people seek physician-assisted death? / Robert A. Pearlman, Helene Starks -- 7. Doctor-patient communication about physician-assisted suicide / Anthony L. Back -- 8. When hastened death is neither killing nor letting die / Tom L. Beauchamp -- 9. Physician-assisted suicide as a last-resort option at the end of life / Dan W. Brock -- 10. Death : a friend to be welcomed, not an enemy to be defeated / John Shelby Spong -- pt. 3. Open practice in a legally tolerant environment -- 11. The Oregon experience / Linda Ganzini -- 12. The distortion of cases in Oregon / Peter Goodwin -- 13. A model that integrates assisted dying with excellent end-of-life care / Barbara Coombs Lee -- 14. Thirty years' experience with euthanasia in the Netherlands : focusing on the patient as a person / Johannes J.M. van Delden, Jaap J.F. Visser, Els Borst-Eilers -- 15. The death of my father / Herman H. van der Kloot Meijburg -- 16. Assisted death in the Netherlands : physicians at the bedside when help is requested / Gerrit K. Kimsma, Evert van Leeuwen -- pt. 4. Political and legal ferment -- 18. Legal advocacy to improve care and expand options at the end of life / Kathryn L. Tucker -- 19. Physician-assisted suicide : shifting the focus from means to ends / Alan Meisel -- 20. Choice in dying : a political and constitutional context / Sylvia A. Law -- 21. Hastening death : the seven deadly sins of status quo / Charles H. Baron -- Conclusion. Excellent palliative care as the standard, physician-assisted dying as a last resort / Timothy E. Quill, Margaret P. Battin.

Physicians at war: the dual-loyalties challenge /Fritz Allhoff --Dual-loyalty and human rights in health professional practice: proposed guidelines and institutional mechanisms /International Dual-Loyalty Working Group --Guidelines to prevent the malevolent use of physicians in war /Michael E. Frisina --Dual disloyalties: law and medical ethics at Guantanamo Bay /Jonathan H. Marks --Toward a framework for military health ethics /Gervase Pearce, Peter Saul --Physician involvement in hostile interrogations /Fritz Allhoff --Indecent medicine revisited: considering physician involvement in torture /Richard Matthews --Torture and the regulation of the health care professions /John Lunstroth --Is medicine a pacifist vocation or should doctors help build bombs? /Michael L. Gross --Thecase against doctor involvement in weapons design and development /Vivienne Nathanson --Armed conflict and value conflict: case studies in biological weapons /Michael J. Selgelid --Ethics and the dual-use dilemma in the life sciences /Seumas Miller, Michael J. Selgelid --Triage priorities and military physicians /Marcus P. Adams --Medical neutrality and political activism: physicians' roles in conflict situations /Justin M. List.

Principles of cancer chemotherapy -- Chemotherapeutic and biologic drugs -- Guidelines for chemotherapy and dosing modifications -- Common chemotherapy regimens in clinical practice -- Antiemetic agents for the treatment of chemotherapy-induced nausea and vomiting.

William Petty 1623-1687 / by Norman D. McMillan -- Robert Boyle 1627-1691 / by D. Thorburn Burns -- William Molyneux 1656-1698 / by Patrick Wayman and Norman D. McMillan -- Nicholas Callan 1799-1864 / by Niall E. McKeith -- William Parsons, Earl of Rosse 1800-1867 / by Bob Strunz -- Humphrey Lloyd 1800-1881 / by James G. O'Hara -- Thomas Grubb 1800-1878 and Howard Grubb 1844-1931 / by Andrew Whitaker -- William Rowan Hamilton 1805-1865 / by John J. O'Connor and Edmund F. Robertson -- James MacCullagh 1809-1847 / by James G. O'Hara -- Thomas Andrews 1813-1885 / by D. Thorburn Burns -- George Gabriel Stokes 1819-1903 / by Alastair Wood -- John Tyndall 1820-1893 / by Norman D. McMillan -- Samuel Haughton 1821-1897 / by Norman D. McMillan -- William Thomson, Lord Kelvin 1824-1907 / by Mark McCartney -- George Johnstone Stoney 1826-1911 / by James G. O'Hara -- George Francis FitzGerald 1851-1901 / by John J. O'Connor and Edmund F. Robertson --John Joly 1857-1933 / by Denis Weaire and Stephen Coonan -- Joseph Larmor 1857-1942 / by Raymond Flood -- Frederick Thomas Trouton 1863-1922 / by James G. O'Hara -- John Sealy Edward Townsend 1868-1957 / by Mark McCartney -- John A. McClelland 1870-1920 / by Thomas C. O'Connor -- Erwin Schrodinger 1887-1961 / by Andrew Whitaker -- Cornelius Lanczos 1893-1974 / by Barbara Gellai -- John Synge 1897-1995 / by Petros S. Florides -- John Desmond Bernal 1901-1971 / by Roy Johnston -- Ernest Walton 1903-1995 / by Brian Cathcart -- Walter Heitler 1904-1981 / by David Glass -- Sir William McCrea 1904-1999 / by Iwan Williams -- Cormac O Ceallaigh 1912-1996 / by Mark McCartney -- David Bates 1916-1994 / by Ray Flannery -- John Stewart Bell 1928-1990 / by Andrew Whitaker -- Lochlainn O Raifeartaigh 1933-2000 / by Siddhartha Sen -- Index of names.

ch. 1. Introduction, p. 1-3 -- ch. 2. Liquid Surfaces, p. 4-25 -- ch. 3. Thermodynamics of Interfaces, p. 26-41 -- ch. 4. The Electric Double Layer, p. 42-56 -- ch. 5. Effects at Charged Interfaces, p. 57-79 -- ch. 6. Surface Forces, p. 80-117 -- ch. 7. Contact Angle Phenomena and Wetting, p. 118-144 -- ch. 8. Solid Surfaces, p. 145-176 -- ch. 9. Adsorption, p. 177-205 -- ch. 10. Surface Modification, p. 206-221 -- ch. 11. Friction, Lubrication, and Wear, p. 223-245 -- ch. 12. Surfactants, Micelles, Emulsions, and Foams, p. 246-279 -- ch. 13. Thin Films on Surfaces of Liquids, p. 280-298 -- ch. 14. Solutions to Exercises, p. 299-320 -- A. Analysis of Diffraction Patterns, p. 321-329 -- B. Symbols and Abbreviations, p. 331-334.

Structure of Matter -- Radioactive Decay -- Kinetics of Radioactive Decay -- Statistics of Radiation Counting -- Production of Radionuclides -- Interaction of Radiation with Matter -- Gas-Filled Detectors -- Scintillation and Semiconductor Detectors -- Gamma Cameras -- Performance Parameters of Gamma Cameras -- Digital Computers in Nuclear Medicine -- Single Photon Emission Computed Tomography -- Positron Emission Tomography -- Internal Radiation Dosimetry -- Radiation Biology -- Radiation Regulations and Protection.

What is nuclear medicine? -- Basic atomic and nuclear physics -- Modes of radioactive decay -- Decay of radioactivity -- Radionuclide and radiopharmaceutical production -- Interaction of radiation with matter -- Radiation detectors -- Electronic instrumentation for radiation detection systems -- Nuclear counting statistics -- Pulse-height spectrometry -- Problems in radiation detection and measurement -- Counting systems -- The gamma camera : basic principles -- The gamma camera : performance characteristics -- Image quality in nuclear medicine -- Tomographic reconstruction in nuclear medicine -- Single photon emission computed tomography -- Positron emission tomography -- Hybrid imaging : SPECT/CT and PET/CT -- Digital image processing in nuclear medicine -- Tracer kinetic modeling -- Internal radiation dosimetry -- Radiation safety and health physics.

Terminology, the standard human, and scaling -- Statics of the body -- Motion -- Mechanical properties of the body -- Muscles -- Metabolism: energy, heat, work, and power -- Fluid pressure, fluid flow in the body, and motion in fluids -- Cardiovascular system -- Lungs and breathing -- Sound, speech, and hearing -- Light, eyes, and vision -- Electrical and magnetic properties -- Feedback and control -- Appendix A. Symbols and units -- Appendix B. Locator of major anatomical and anthropometric information -- Appendix C. Differential equations -- Appendix D. Similar model systems -- Appendix E. Biophysics of the human body.

Recent Developments in the Molecular Taxonomy of Fungi / Roland W.S. Weber -- Sordaria macrospora, a Model System for Fungal Development / Ulrich Kück, Stefanie Pöggeler, Minou Nowrousian, Nicole Nolting and Ines Engh -- Inteins - Selfish Elements in Fungal Genomes / Skander Elleuche and Stefanie Pöggeler -- Apoptosis in Fungal Development and Ageing / Diana Brust, Andrea Hamann and Heinz D. Osiewacz -- Communication of Fungi on Individual, Species, Kingdom, and Above Kingdom Levels / Ursula Kües and Mónica Navarro-González -- Yeast Killer Toxins: Fundamentals and Applications / Friedhelm Meinhardt and Roland Klassen -- Evolutionary and Ecological Interactions of Mould and Insects / Marko Rohlfs, Monika Trienens, Ulrike Fohgrub and Frank Kempken -- Endophytic Fungi, Occurrence and Metabolites / Daniela Weber -- Fungal Origin of Ergoline Alkaloids Present in Dicotyledonous Plants (Convolvulaceae) / Eckhard Leistner and Ulrike Steiner -- Secondary Metabolites of Basidiomycetes / Anja Schüffler and Timm Anke -- Identification of Fungicide Targets in Pathogenic Fungi / Andrew J. Foster and Eckhard Thines -- Helminth Electron Transport Inhibitors Produced by Fungi / Rokuro Masuma, Kazuro Shiomi and Satoshi Ōmura -- Cyclic Peptides and Depsipeptides from Fungi / Heidrun Anke and Luis Antelo -- Fungal Genome Mining and Activation of Silent Gene Clusters / Axel A. Brakhage, Sebastian Bergmann, Julia Schuemann, Kirstin Scherlach and Volker Schroeckh, et al. -- Non-Ribosomal Peptide Synthetases of Fungi / Katrin Eisfeld -- Biosynthesis of Fungal Polyketides / Julia Schuemann and Christian Hertweck -- Physiological and Molecular Aspects of Ochratoxin A Biosynthesis / Rolf Geisen and Markus Schmidt-Heydt -- Genetic and Metabolic Engineering in Filamentous Fungi / Jochen Schmid, Ulf Stahl and Vera Meyer.

Part I. Overview of Chloride Transporters and Channels -- Part II. Current Methods for Studying Chloride Regulation -- Part III. From Cloning to Structure, Function and Regulation of Chloride Transporters and Channels -- Part IV. Cation-Chloride Cotransporters in Neural Function and Dysfunction -- Part V. Cation-Chloride Cotransport in Choroid Plexus and Blood-Brain Barrier.

Measuring endogenous electric fields / Richard Nuccitelli -- Investigation systems to study the biological effects of weak physiological electric fields / Francis X. Hart -- Endogenous bioelectric signals as morphogenetic controls of development, regeneration, and neoplasm / Michael Levin -- Stem cell physiological responses to noninvasive electrical stimulation / Igor Titushkin ... [et al.] -- Electrical signals control corneal epithelial cell physiology and wound repair / Colin D. McCaig -- Physiological electric fields can direct keratinocyte migration and promote healing in chronic wounds / Christine E. Pullar -- Electrical control of angiogenesis / Entong Wang ... [et al.] -- Inflammatory cell electrotaxis / Francis Lin and Christine E. Pullar -- Effects of DC electric fields on migration of cells of the musculoskeletal system / Najmuddin J. Gunja, Clark T. Hung, and J. Chlöe Bulinski -- Neuronal growth cone guidance by physiological DC electric fields / Ann M. Rajnicek -- Can applied voltages be used to produce spinal cord regeneration and recovery in humans? / Richard Ben Borgens -- Bioelectricty of cancer : voltage-gated ion channels and direct-current electric fields / Mustafa B. A. Djamgoz.

Maternal Exercise Throughout Gestation and Fetal Development --Effects of Maternal Exercise on Labor and Delivery --Fetal and Postnatal Growth and Development --Effect on Postnatal Health and Beyond --What are the Barriers to and What is OK for an Exercise Study --Conclusions.

V. I. Sect. I. Basic cell physiology, genetics, and growth of the GI tract. Transcription and epigenetic regulation / Juanita L. Merchant -- Post-translational processing of gastrointestinal peptides / Graham S. Baldwin -- Genetic tools in gastrointestinal diseases / Clara Abraham and Judy Cho -- Signaling pathways induced by G-protein-coupled receptors / Enrique Rozengurt -- Transgenic animal models of gastrointestinal function / Marie-Pier Tetreault and Jonathan P. Katz -- Gastrointestinal function / Marie-Pier Tetreault and Jonathan P. Katz -- Gastrointestinal peptides: gastrin, cholecystokinin, somatostatin, and ghrelin / Celia Chao and Mark R. Hellmich -- Postpyloric gastrointestinal peptides / Guillermo A. Ggomez, Ella W. Englander, and George H. Greeley, Jr. -- Growth factors in the gastrointestinal tract / John F. Kuemmerle -- Developmental signaling networks: WNT/[beta]-catenin signaling in the gastrointestinal tract / Guido T. Bommer and Eric R. Fearon -- Hedgehog signaling in gastrointestinal morphogenesis and morphostasis / Willemijn A. van Dop and Gijs R. van den Brink -- Notch pathway regulation of intestinal cell fate / Kelli L. Van Dussen, Peter J. Dempsey, and Linda C. Samuelson --Stem cells in the gastrointestinal tract / Nicholas A. Wright -- Programmed cell death in the gastrointestinal tract / Leonard R. Johnson and Ramesh M. Ray -- Molecular physiology of gastrointestinal function during development / Hua Xu, James F. Collins, and Fayez K. Ghishan -- The cell cycle / Vincent W. Yang -- Sect. II. Neurogastroenterology. Development of the enteric nervous system / Heather M. Young, Donald F. Newgreen, and Hideki Enomoto -- Cellular physiology of gastrointestinal smooth muscle / Khalil N. Bitar ... [et al.] -- Organization and electrophysiology of interstitial cells of cajal and smooth muscle cells in the gastrointestinal tract / Kenton M. Sanders, Sang Don Koh, and Sean M. Ward -- Enteric nervous system structure and neurochemistry related to function and neuropathology / Daniel P. Poole and John B. Furness -- Physiology of prevertebral sympathetic ganglia / Joseph H. Szurszewski and David R. Linden -- Cellular neurophysiology of enteric neurons / Jackie D. Wood -- Integrative functions of the enteric nervous system / Jackie D. Wood -- Processing of gastrointestinal sensory signals in the brain / Steven J. Coen, Anthony R. Hobson, and Qasim Aziz --Innervation of the gastrointestinal tract by spinal and vagal afferent nerves / Stuart M. Brierley ... [et al.] -- Neuroimaging of brain-gut interactions in functional gastrointestinal disorders / Kirsten Tillisch ... [et al.] -- The neurobiology of gustation: taste buds and transduction processes / Scott Herness -- Enteric neural regulation of mucosal secretion / Joel C. Bornstein, Rachel M. Gwynne, and Henrik Sjövall -- Hypothalamic-pituitary-adrenal axis in gastrointestinal physiology / Shin Fukudo -- Neural regulation of gastrointestinal blood flow / Peter Holzer -- Neuromuscular function in the biliary tract / Gary M. Mawe ... [et al.] -- Brainstem control of the gastric function / Richard C. Rogers and Gerlinda E. Hermann -- Physiology of aerodigestive reflexes in neonates and adults / Sudarshan R. Jadcherla and Reza Shaker -- Motor function of the pharynx, the esophagus, and its sphincters / Ravinder K. Mittal -- Neurophysiologic mechanisms of gastric reservoir function / Jan Tack -- Physiology of the antral pump and gastric emptying / Christopher K. Rayner, Geoffrey S. Hebbard, and Michael Horowitz -- Neurophysiologic mechanisms of human large intestinal motility / Adil E. Bharucha and Simon J.H. Brookes --Neuromuscular physiology of the pelvic floor / Arnold Wald -- Sect. III. Host defense mechanisms. tight junctions and theintestinal barrier / Thomas Y. ma, James M. Anderson, and Jerrold R. Turner -- Biology of gut immunoglobulins / Finn-Eirik Johansen ... [et al.] -- Gastrointestinal microbial ecology with perspectives on health and disease / Merritt G. Gillilland, vincent B. Young, and Gary B. Huffnagle -- Mucsoal bacterial recognition and signaling systems in the intestine / masayuki Fukata and Maria T. Abreu -- Mucosal restitution and repair / D. Brent Polk and Mark R. Frey -- Gastroduodenal mucosal defense / Maggie Ham ... [et al.] -- V. II. Sect. IV. Physiology of secretion. Paneth cells / André J. Ouellette -- Salivary gland secretion / Marcelo A. Catalán, Kiran S. Ambatipudi, and James E. Melvin -- The cell biology of gastric acid secretion / Curtis Okamoto ... [et al.] -- Regulation of gastric acid secretion / Mitchell L. schubert -- Gastroduodenal bicarbonate secretion / Ursula Seidler and Markus Sjöblom -- Structure-function relationships in the pancreatic acinar cell / Fred S. Gorelick and James D. Jamieson -- Stimulus-secretion coupling in pancreatic acinar cells / John A. Williams and David I. Yule --Cell physiology of pancreatic ducts / Barry E. Argent ... [et al.] -- Regulation of pancreatic secretion / Rodger A. Liddle -- Bile formation and the enterohepatic circulation / Paul A. Dawson -- Mechanisms of hepatocyte organic anion transport / Allan W. Wolkoff -- Mechanisms of hepatocyte detoxification / Donald J. Messner, Karen F. Murray, and Kris V. Kowdley -- Sect. V. Digestion and absorption. Physiology of cholangiocytes / Anatoliy I. Masyuk, Tatyana V. Masyuk, and Nicholas F. LaRusso -- Molecular mechanisms of protein sorting in polarized epithelial cells / Bernardo Ortega and Paul A. Welling -- Sugar absorption / Ernest M. Wright ... [et al.] -- Protein digestion andabsorption / Vadivel Ganapathy -- Enterocyte fatty acid handling proteins and chylomicron formation / Charles M. Mansbach, II and Nada A. Abumrad -- Genetic regulation of intestinal lipid transport and metabolism / Zhouji Chen and Nicholas O. Davidson -- Digestion and intestinal absorption of dietary carotenoids and vitamin A / Earl H. Harrison -- 1,25-dihydroxyvitamin D3: synthesis, actions, and genome-scale mechanisms in the intestine and colon /J. Wesley Pike and Mark B. Meyer --Mechanisms and regulation of intestinal absorption of water-soluble vitamins: cellular and molecular aspects / Hamid M. Said and Ebba Nexo -- Water transport in the gastrointestinal tract / Jay R. Thiagarajah and A.S. Verkman -- Na+/H+ exchange in mammalian digestive tract / Pawel R. Kiela and Fayez K. Ghishan -- Intestinal antion absorption / Ravinder K. Gill ... [et al.] -- cAMP sensor epac and gastrointestinal function / Oleg G. Chepurny ... [et al.] -- Ion channels of the epithelia of the gastrointestinal tract / John Cuppoletti and Danuta H. Malinowska -- Molecular mechanisms of intestinal transport of calcium, phosphate, and magnesium / Pawel R. Kiela, James F. Collins, and Fayez K. Ghishan -- Molecular mechanisms of intestinal iron transport / James F. Collins and Gregory J. Anderson -- Sect. VI. Consequences of disregulated physiology. Trace element absorption and transport / Robert J. Cousins -- The gastrointestinal tract and control of food intake / Guillaume de Lartigue and Helen E. Raybould -- Effects of stress on intestinal mucosal functions / Johan D. Söderholm -- Enteric neurobiology of stress / Sumei Liu and Jackie D. Wood --Mechanisms of helicobacter pylori-induced gastric inflammation / Dawn A. Israel and Richard M. Peek, Jr. -- Physiology of host-pathogen interactions / Kim Hodges and Gail Hecht -- Mechanisms and consequences of intestinal inflammation / Derek M. McKay and Wallace K. MacNaughton -- Recruitment of inflammatory and immune cells in the gut: physiology and pathophysiology / D. Neil Granger, Christopher G. Kevil, and Matthew B. Grisham -- Mechanisms of GI malignancies /John P. Lynch and Anil K. Rustgi -- Pathophysiology underlying the irritable bowel syndrome / Jackie D. Wood -- Pathophysiology of diarrhea and its clinical implications / Rana F. Ammoury and Fayez K. Ghishan.

"Preface The aim of this book is to show that many aspects of human physiology lend themselves to numerical analysis. Many ways of monitoring physiological function also rely on an understanding of physics and engineering to appreciate fully how they operate. The book arises out of an undergraduate course in medical biophysics and a postgraduate course in biomedical instrumentation the authors were involved in for many years. Although the emphasis is on numerical analysis only, a basic knowledge of mathematics is assumed and every effort is made to supplement mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes involved. Most of the chapters have a range of numerical tutorial problems with, in most cases, worked solutions. These are based on examination questions at the middle and senior undergraduate level. For some of the material, the computational package MATLABʼ offers a convenient way to gain insight into some of the more advanced mathematical analysis of physiological or of clinical monitoring systems. Suitable MATLAB code is provided where this might aid understanding. I acknowledge the help of colleagues in the preparation of this book. Particular chapters have been authored as follows: Anthony Bartel, Per Line, Peter Cadusch, Joseph Ciorciari, David and Sheila Crewther, John Patterson , Mark Schier, Bruce Thompson. In addition, others have been associated with teaching the course over many years. These include: Peter Alabaster, David Liley, Ric Roberts and David Simpson"--Provided by publisher.

High-Yield Facts -- General Principles: Cellular Physiology -- General Principles: Multisystem Processes -- Physiology of the Hematopoietic and Lymphoreticular Systems -- Neurophysiology -- Musculoskeletal Physiology -- Respiratory Physiology -- Cardiovascular Physiology -- Gastrointestinal Physiology -- Renal and Urinary Physiology -- Reproductive Physiology -- Endocrine Physiology.

Cell physiology -- Neurophysiology -- Cardiovascular physiology -- Respiratory physiology -- Renal and acid-base physiology -- Gastrointestinal physiology -- Endocrine physiology.

Technophysiology, evolution, and aging : towards a new image of aging / Paola S. Timiras -- Are there age-related changes in flavonoid bioavailability? / C-Y. Oliver Chen and Jeffrey B. Blumberg -- Trends in the analysis of phytochemicals : flavonoids and carotenoids / Eunmi Koh and Alyson E. Mitchell -- Anti-inflammatory botanicals : a case study of genetic screens as part of a pharmacogenomic approach / Moul Dey ... [et al.] -- Characteristics and functions of lutein and zeaxanthin within the human retina / Billy R. Hammond, Jr. and Lisa M. Renzi -- Phytochemicals and the aging brain / Stephane Bastianetto and Remi Quirion -- Green tea : skin care and skin diseases / Stephen D. Hsu -- Pomegranate phenolics antioxidant activities protect against cardiovascular diseases / Michael Aviram, Mira Rosenblat, and Bianca Fuhrman -- Customizing dietary recommendations by genotype in the era of genomics / Sina Vakili, Grace Jooyoung Shin, and Marie A. Caudill -- Development of a botanical combination product for allergy symptoms / Marc Lemay ... [et al.] -- Genotype-selective inhibition of IL-1 by botanicals : a nutrigenetics proof of principle / R. Keith Randolph.

Absorption and metabolism of anthocyanins and other phenolics in human subjects / Ronald L. Prior -- Absorption and metabolism of the dietary phytochemical, quercetin / Gary Williamson -- Pharmacokinetics and bioavailability of green tea catechins / H-H. Sherry Chow -- The importance of in vivo metabolism of polyphenols and their biological action / Stephen Barnes -- Cancer prevention by phytochemicals, modulation of cell cycle / Diane F. Birt -- Cancer chemoprevention by phytopolyphenols including flavanoids and flavonoids through modulating signal transduction pathways / Jen-Kun Lin -- Gene regulation by glucosinolate hydrolysis products / Elizabeth H. Jeffery -- Healthy food vs. phytosterol fortified foods for primary prevention of coronary artery disease / Douglas S. Lewis -- Vascular effects of resveratrol / Joseph M. Wu -- Development of a mixture of dietary carotenoids as cancer chemopreventive agents: C57BL/6J mice as a useful animal model for efficacy studies with carotenoids / Frederick Khachik -- Chemoprevention of colon cancer by curcumin / Bandaru S. Rdddy.

Nutritional genomics / Ruan M. Elliott, James R. Bacon, and Yongping Bao -- Methods to study bioavailability of phytochemicals / Birgit Holst and Gary Williamson -- Characterization of polyphenol metabolites /Andrea J. Day, Joseph A. Rothwell, and Michael R.A. Morgan -- Microarray profiling of gene expression patterns of genistein in tumor cells / Ching Li and Biehuoy Shieh -- Gene regulatory activity of Ginkgo biloba L. / Gerald Rimbach, Rainer Cermak, and Siegfried Wolffram -- Cancer chemoprevention with sulforaphane, a dietary isothiocyanate / Yuesheng Zhang -- Phytochemicals protect against heterocyclic amine-induced DNA adduct formation / Yongping Bao and James R. Bacon -- Organosulfur-garlic compounds and cancer prevention / John Milner -- Polymethylated flavonoids: cancer preventive and therapeutic potentials derived from anti-inflammatory and drug metabolism-modifying properties / Akira Murakami and Hajime Ohigashi -- Biochemical and molecular mechanisms of cancer chemoprevention by tea and tea polyphenols / Jen-Kun Lin -- The role of flavonoids in protection against cataract / Julie Sanderson and W. Russell McLauchlan -- Effects of oltipraz on phase 1 and phase 2 xenobiotic-metabolizing enzymes / Sophie Langouet, Fabrice Morel and Andre Guillouzo -- Future perspectives in phytochemical and health research / Yongping Bao and Roger Fenwick.

Effect of Lifestyle, Aging, and Phytochemicals on the Onset of Neurological Disorders --Beneficial Effects of Extra Virgin Olive Oil (n-9 Fatty Acids) on Neurological Disorders --Beneficial Effects of Flaxseed Oil (n-3 Fatty Acids) on Neurological Disorders --Beneficial Effects of Flavonoids on Neurological Disorders --Beneficial Effects of Green Tea Catechins on Neurological Disorders --Beneficial Effects of Curcumin on Neurological Disorders --Beneficial Effects of Resveratrol on Neurological Disorders --Beneficial Effects of Ginkgo biloba in Neurological Disorders --Beneficial Effects of Garlic Components on Neurological Disorders --Beneficial Effects of Propolis on Neurological Disorders --Perspective and Direction for Future Research on Phytochemicals in Neurological Disorders.

Generic Comments on Isoflavones and Other Phytoestrogens -- Chapter 1. Brief Historical Overview of Isoflavone Research / Mark Messina -- Chapter 2. Soy Isoflavones as Functional Ingredients in Women's Health / Clare M. Hasler and Susan Kundrat -- Chapter 3. Isoflavone Supplements: Arguments For and Against Their Use / Mark Messina -- Chapter 4. Industrial Processing and Preparation of Isoflavones / Eric T Gugger -- Food Sources and Composition of Phytoestrogens -- Chapter 5. Human Dietary Sources of Phytoestrogens and Methods of Determination / Chung-Ja C. Jackson and H.P. Vasantha Rupasinghe -- Chapter 6. Tables of Isoflavone, Coumestan, and Lignan Data / Chung-Ja C. Jackson and G. Sarwar Gilani -- Measurement Methodology of Phytoestrogens in Blood and Tissues -- Chapter 7. Analysis of Phytoestrogens in Biological Samples by Mass Spectrometry / Jeevan K. Prasain, Chao-Cheng Wang, and Stephen Barnes -- Chapter 8. Measurement Methodology for Phytoestrogens in Blood and Urine / Mariko Uehara -- Chapter 9. Metabolism and Disposition of Genistein, the Principal Soy Isoflavone / Daniel R. Doerge, Richard H. Luecke, and John F Young -- Digestion, Absorption and Metabolism of Isoflavones -- Chapter 10. Digestion, Absorption and Metabolism of Isoflavones / Roger A. King -- Cellular Mechanism of Action, Including Estrogen Receptors -- Chapter 11. Cellular Mechanisms of Action Including Estrogen Receptors: ER[alpha] and [beta] / Sari Mäkelä and Jan-Åke Gustafsson -- Chapter 12. Effects of Phytoestrogens on Bone Cells: Genomic and Nongenomic Mechanisms / Xiaowei Chen and John J.B. Anderson -- Cardiovascular Effects -- Chapter 13. Epidemiology of Soy Isoflavones and Cardiovascular Disease / M.Z. Vitolins, M.S. Anthony, and G.L. Burke -- Chapter 14. Soy/Isoflavones and Risk Factors for Cardiovascular Disease / Mary S. Anthony -- Chapter 15. Soy Proteins, Isoflavones, Cardiovascular Risk Factors, and Chronic Disease / David J.A. Jenkins, Cyril WC. Kendall, and Augustine Marchie -- Chapter 16. Lipoprotein Effects of Soybean Phytoestrogens / Sandra R. Teixeira and John W Erdman, Jr. -- Chapter 17. Effects of Free (Aglycone) Phytoestrogens and Metabolites on Cardiovascular Functions and Cancer / Paul Nestel and Alan Husband -- Skeletal Effects -- Chapter 18. Association Between Soy and/or Isoflavones and Bone: Evidence from Epidemiologic Studies / Mary S. Anthony, John J.B. Anderson, and D. Lee Alekel -- Chapter 19. Skeletal Effects of Phytoestrogens in Humans: Bone Mineral Density and Bone Markers / John J.B. Anderson and D. Lee Alekel -- Chapter 20. Skeletal Effects of Phytoestrogens: Rodent Models: Diet / Bahram H. Arjmandi and Brenda J. Smith -- Cancer -- Chapter 21. Phytoestrogens and Cancer: Epidemiologic Evidence / Anna H. Wu -- Chapter 22. Flaxseed Lignans: Health Benefits, Bioavailability, and Safety / Lilian U. Thompson and Wendy E. Ward -- Chapter 23. Phytoestrogens, Estrogens and Risk of Colon Cancer / Maurice R. Bennink and Elizabeth A. Rondini -- Chapter 24. Phytoestrogen Actions in the Breast and Uterus / Charles E. Wood, Stephen Barnes, and J. Mark Cline -- Chapter 25. Induction of Apoptosis by Genistein: Potential Applications in Cancer Prevention and Treatment / Andreas I. Constantinou -- Renal Effects -- Chapter 26. Phytoestrogens: Diabetic Nephropathy / Tammy J. Stephenson and James W Anderson -- Premenopausal Hormone Effects -- Chapter 27. Hormonal Effects of Phytoestrogens in Premenopausal Women / Alison M. Duncan, William R. Phipps, and Mindy S. Kurzer -- Postmenopausal, Potential Alternative to Traditional HRT -- Chapter 28. Phytoestrogens: Effects on Menopausal Symptoms / Fabien S. Dalais -- Chapter 29. Use of Soy Isoflavones as an Alternative to Traditional Hormone Replacement Therapy / Mara Z. Vitolins, Mary S. Anthony, and Gregory L. Burke -- Safety and Potential Toxicity -- Chapter 30. Deleterious Effects of Genistein Follow Exposure During Critical Stages of Development / Retha R. Newbold, Wendy Jefferson, Elizabeth Padilla-Banks, and Bill Bullock -- Chapter 31. Evaluation of Phytoestrogen Safety and Toxicity in Rodent Models That Include Developmental Exposure / Barry Delclos -- Chapter 32. The Health Consequences of Soy Infant Formula, Soy Protein Isolate, and Isoflavones / Thomas M. Badger, Martin J.J. Ronis, Reza Hakkak, and Sohelia Korourian -- Chapter 33. Public Health Implications of Dietary Phytoestrogens / Joel Rotstein, and G. Sarwar Gilani.

Introduction : distinction between Pichia pastoris and other expression systems / James M. Cregg -- Vectors and strains for expression / Joan Lin-Cereghino and Geoff P. Lin-Cereghino -- DNA-mediated transformation / James M. Cregg -- Rational design and optimization of fed-batch and continuous fermentation / Wenhui Zhag, Mehmet Inan, and Michael M. Meagher -- Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) protein (Na-ASP1) / Mehmet Inan ... [et al.] -- Purification of the N- and C-terminal subdomains of recombinant heavy chain fragment C of botulinum neurotoxin serotype C / Jicai Huang ... [et al.] -- Rapid screening of chromatography resins for the purification of proteins / Sandra E. Ríos, Erin M. Giaccone, and Tillman U. Gerngross -- Characterization of O-linked saccharides on glycoproteins / Roger K. Bretthauer -- Modification of the N-glycosylation pathway to produce homogeneous human-like glycans using glycoswitch plasmids / Wouter Vervecken ... [et al.] -- N-linked glycan characterization of heterologous proteins / Huijan Li ... [et al.] -- Heavy labeling of recombinant proteins / Eric Rodriguez -- Selenomethionine labeling of recombinant proteins / Anna M. Larsson and T. Alwyn Jones -- Selective isotopic labeling of recombinant proteins using amino acid auxotroph strains / James W. Whittaker -- Classical genetics / Ilya Tolstorukov and James M. Cregg -- Identification of pexophagy genes by restriction enzyme-mediated integration / Laura A. Schroder, Benjamin S. Glick, and William A. Dunn, Jr. -- Characterization of protein-protein interactions : application to the understanding of peroxisome biogenesis / Sebastien Leon ... [et al.] -- Localization of proteins and organelles using fluorescence microscopy / Jean-Claude Farre ... [et al.] -- Fluorescence microscopy and thin-section electron microscopy / Benjamin S. Glick.

A history of the science of pigmentation / Sidney N. Klaus -- Comparative anatomy and physiology of pigment cells in nonmammalian tissues / Joseph T. Bagnara & Jiro Matsumoto -- General biology of mammalian pigmentation / Walter C. Quevedo Jr. & Thomas J. Holstein -- Extracutaneous melanocytes / Raymond E. Boissy & Thomas J. Hornyak -- Regulation of melanoblast migration and differentiation / David M. Parichy, Mark V. Reedy, & Carol A. Erickson -- Melanoblast development and associated disorders / Richard A. Spritz -- Biogenesis of melanosomes / Raymond E. Boissy, Marjan Huizing, & William A. Gahl -- Melanosome trafficking and transfer / Glynis A. Scott -- Melanosome processing in keratinocytes / H. Randolph Byers -- The regulation of melanin formation / Vincent J. Hearing -- The tyrosinase gene family / William S. Oetting & Vijayasaradhi Setaluri -- Molecular regulation of melanin formation: melanosome transporter proteins / Murray H. Brilliant -- Transcriptional regulation of melanocyte function / Kazuhisa Takeda & Shigeki Shibahara -- Enzymology of melanin formation / Francisco Solano & José C. García-Borrón -- Chemistry of melanins / Shosuke Ito & Kazumasa Wakamatsu -- The physical properties of melanins / Tadeusz Sarna & Harold A. Swartz -- Photobiology of melanins / Antony R. Young -- Toxicological aspects of melanin and melanogenesis / Edward J. Land, Christopher A. Ramsden & Patrick A. Riley -- Regulation of pigment type switching by agouti, melanocortin signaling, attractin, and mahoganoid / Gregory S. Barsh -- Human pigmentation: its regulation by ultraviolet light and by endocrine, paracrine and autocrine factors / Zalfa Abdel-Malek & Ana Luisa Kadekaro -- Paracrine interactions of melanocytes in pigmentary disorders / Genji Imokawa -- Growth factor receptors and signal transduction regulating the proliferation and differentiation of melanocytes / Ruth Halaban & Gisela Moellmann -- Aging and senescence of melanocytes / Debdutta Bandyopadhyay & Estela E. Medrano -- The genetics of melanoma / Vanessa C. Gray-Schopfer & Dorothy C. Bennett -- The transformed phenotype of melanocytes / Dong Fang & Meenhard Herlyn --A more precise lexicon for pigmentation, pigmentary disorders, and "chromatic" abnormalities / James J. Nordlund ... [et al.] -- The normal color of human skin / James J. Nordlund & Jean-Paul Ortonne -- Mechanisms that cause abnormal skin color / Jean-Paul Ortonne & James J. Nordlund -- Genetic hypomelanoses: disorders characterized by congenital white spotting-piebaldism, Waardenburg syndrome, and related genetic disorders of melanocyte development-clinical aspects / Richard A. Spritz -- Genetic hypomelanoses: acquired depigmentation -- Genetic hypomelanoses: generalized hypopigmentation -- Genetic hypomelanoses: localized hypopigmentation -- Genetic hypomelanoses: disorders characterized by hypopigmentation of hair -- Metabolic, nutritional and endocrine disorders -- Chemical, pharmacologic and physical agents causing hypomelanoses -- Infectious hypomelanoses / Jean-Philippe Lacour-- Inflammatory hypomelanoses / Jean-Philippe Lacour -- Hypomelanoses associated with melanocytic neoplasia / Lieve Brochez, Barbara Boone, & Jean-Marie Naeyaert -- Miscellaneous hypomelanoses: depigmentation -- Miscellaneous hypomelanoses: hypopigmentation -- Miscellaneous hypomelanoses: extracutaneous loss of pigmentation -- Hypochromia without hypomelanosis / Jean-Philippe Lacour --Genetic epidermal syndromes: disorders characterized by generalized hyperpigmentation -- Genetic epidermal syndromes: disorders characterized by reticulated hyperpigmentation -- Genetic epidermal syndromes with Café-au-Lait macules -- Genetic epidermal pigmentation with lentigines -- Genetic epidermal syndromes: localized hyperpigmentation -- Genetic epidermal syndromes: disorders of aging -- Congenital epidermal hypermelanoses -- Acquired epidermal hypermelanoses -- Hypermelanosis associated with gastrointestinal disorders -- Acquired and congenital dermal hypermelanosis -- Mixed epidermal and dermal hypermelanoses and hyperchromias -- Drug-induced or -related pigmentation -- The melanocyte system of the nails and its disorders -- Pigmentary abnormalities and discolorations of the mucous membranes / John C. Maize, Jr. & John C. Maize, Sr. -- Common benign neoplasms of melanocytes -- Rare benign neoplasms of melanocytes -- Topical treatment of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Chemophototherapy of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- UVB therapy for pigmentary disorders / Thierry Passeron & Jean-Paul Ortonne -- Sunscreens and cosmetics / James J. Nordlund & Rebat M. Halder -- Surgical treatments of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Laser treatment of pigmentary disorders / Rebat M. Halder, Lori M. Hobbs, & James J. Nordlund.

Statistical analysis of pineal tumors based on the data of brain tumor registry of Japan / Shibui, S., Nomura, K. -- Pathology of pineal parenchymal tumors / Sato, K., Kubota, T. -- Occipital transtentorial approach and combined treatments for pineal parenchymal tumors / Tsumanuma, I., Tanaka, R., Fujii, Y. -- Role of stereotactic radiosurgery in the management of pineal parenchymal tumors -- Kano, H. ... [et al.] -- Pathology of intracranial germ cell tumors / Sato, K., Takeuchi, H., Kubota, T. -- Pineal germ cell tumors / Matsutani, M. -- Strategy of combined treatment of germ cell tumors / Sawamura, Y. -- Radiation therapy for intracranial germ cell tumors / Aoyama, H. -- Stereotactic radiosurgery for pineal and related tumors / Mori, Y. ... [et al.] -- Management of central nervous system germinoma : proposal for a modern strategy / Shibamoto, Y. -- Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy / Sugiyama, K. ... [et al.].

Why it matters -- Tackling hospital-acquired infections -- Moving closer to the patient -- Reducing medication errors -- Eliminating the wait -- Applying best practices -- Transforming a medical specialty.

Role of transcranial approaches in the treatment of sellar and suprasellar lesions / Maartens, N.F.; Kaye, A.H -- Extended transsphenoidal approach / Dumont, A.S. ... [et al.] -- Image guidance in pituitary surgery / Asthagiri, A.R.; Laws, E.R. Jr.; Jane, J.A. Jr. -- Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas / Frank, G.; Pasquini, E. -- Diagnosis and management of pediatric sellar lesions / Jagannathan, J.; Dumont, A.S.; Jane, J.A. Jr. -- The craniopharyngioma / Oskouian, R.J.; Samii, A.; Laws, E.R. Jr. -- Rathke's cleft cysts / Kanter, A.S. ... [et al.] -- Treatment of Cushing's disease : a retrospective clinical study of the latest 100 cases / Hofmann, B.M.; Fahlbusch, R. -- Stereotactic radiosurgery for pituitary adenomas : a review of the literature and our experience / Sheehan, J.P. ... [et al.] -- Neuropathological considerations of pituitary adenomas / Asthagiri, A.; Lopes, M.B.S. -- Anesthetic and critical care management of patients undergoing pituitary surgery / Burton, C.M.; Nemergut, E.C. -- Vascular injury and transsphenoidal surgery / Oskouian, R.J.; Kelly, D.F.; Laws, E.R. Jr.

Implication of pituitary tropic status on tumor development / I. Donangelo, S. Melmed -- Anterior pituitary cell renewal during the estrous cycle / M. Candolfi ... [et al.] -- Bone morphogenetic protein-4 control of pituitary pathophysiology / D. Giacomini ... [et al.] -- Genesis of prolactinomas: studies using estrogen-treated animals / D.K. Sarkar -- Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma / C. Cristina ... [et al.] -- Vasoinhibins: a family of n-terminal prolactin fragments that inhibit angiogenesis and vascular function / C. Clapp ... [et al.] -- Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes / J. Drouin -- Long-term follow-up of prolactinomas: should dopamine agonist treatment be life-long? / M. Guitelman -- Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions / F. Broglio ... [et al.] -- Regulating of growth hormone sensitivity by sex steroids: implications for therapy / K.K.Y. Ho ... [et al.] -- Acromegaly: molecular expression of somatostatin receptor subtypes and treatment outcome / M.D. Bronstein -- Gene therapy in the neuroendocrine system / C.B. Hereñú ... [et al.] -- Ectopic ACTH syndrome / A.M. Isidori, G.A. Kaltsas, A.B. Grossman -- Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function / A.F. De Nicola ... [et al.] -- New aspects in the diagnosis and treatment of Cushing disease / M. Labeur ... [et al.].

Chapter 1. Pituitary Development / Jacques Drouin -- Chapter 2. Hypothalamic Regulation of Anterior Pituitary Function / Anat Ben-Shlomo, Shlomo Melmed -- Chapter 3. Adrenocorticotropin / Oulu Wang, Joseph A. Majzoub -- Chapter 4. Growth Hormone / Vivien S. Herman-Bonert, Shlomo Melmed -- Chapter 5. Prolactin / Mary P. Gillam, Mark E. Molitch -- Chapter 6. Thyroid-stimulating Hormone / Virginia D. Sarapura, David F. Gordon, Mary H. Samuels -- Chapter 7. Gonadotropin Hormones / Ursula B. Kaiser -- Chapter 8. The Posterior Pituitary / Daniel G. Bichet -- Chapter 9. The Hypothalamus / Glenn D. Braunstein -- Chapter 10. Anterior Pituitary Failure / John D. Carmichael -- Chapter 11. Pituitary Function in Systemic Disorders / Harold E. Carlson -- Chapter 12. The Pituitary Gland in Pregnancy and the Puerperium / Harold E. Carlson -- Chapter 13. Drugs and Pituitary Function / Harold E. Carlson -- Chapter 14. Acromegaly / Shlomo Melmed -- Chapter 15. Prolactinoma / Mary P. Gillam, Mark E. Molitch -- Chapter 16. Cushing's disease / Xavier Bertagna, Laurence Guignat, Marie-Charles Raux-Demay, Brigitte Guilhaume, François Girard -- Chapter 17. Thyrotropin-Secreting Pituitary Tumors / Vanessa Rouach, Yona Greenman -- Chapter 18. Gonadotroph Adenomas / Peter J. Snyder -- Chapter 19. Nonpituitary Tumors of the Sellar Region / Olga Moshkin, Steffen Albrecht, Juan M. Bilbao, Kalman Kovacs -- Chapter 20. Pituitary Imaging / Marcel M. Maya, Barry D. Pressman -- Chapter 21. Pituitary Surgery / Rudolf Fahlbusch, Michael Buchfelder.

Pivot table fundamentals and ground rules -- Creating your first pivot table -- Customizing your pivot table -- Controlling the way you view your pivot data -- Performing calculations within your pivot tables -- Creating and using pivot charts -- Analyzing disparate data sources with pivot tables -- Taking your pivot tables to the web -- Working with and analyzing olap data sources -- Enhancing pivot reports with macros -- Using vba to create pivot tables -- Common pivot table issues and questions -- A pivot table function map.

The EMBL nucleotide sequence and genome reviews databases / Peter Sterk ... [et al.] -- Using GenBank / David Wheeler -- A collection of plant-specific genomic data and resources at NCBI / Tatiana Tatusova, Brian Smith-White, and James Ostell -- UniProtKB/Swiss-Prot / Emmanuel Boutet ... [et al.] -- Plant database resources at The Institute for Genomic Research / Agnes P. Chan... [et al.] -- MIPS plant genome information resources / Manuel Spannagl ...[et al.] -- HarvEST / Timothy J. Close ... [et al.] -- The TAIR database / Rebecca L. Poole -- AtEnsEMBL / Nick James ... [et al.] -- Accessing integrated Brasica genetic and genomic data using the BASC server / Christopher G. Love and David Edwards -- Leveraging model legume information to find candidate genes for soybean sudden death syndrome using the Legume Information System / Michael D. Gonzales ... [et al.] -- Legume resources : MtDB and Medicago.org / Ernest F. Retzel ... [et al.] -- BGI-RIS V2 / Ximiao He and Jun Wang -- GrainGenes / Helen O'Sullivan -- Gramene / Doreen Ware -- MaizGDB / Carolyn J. Lawrence -- BarleyBase/PLEXdb / Roger P. Wise ... [et al.] -- Reaping the benefits of SAGE / Stephen J. Robinson ... [et al.] -- Methods for analysis of gene expression in plants using MPSS / Kan Nobuta, Kalyan Vemaraju, and Blake C. Meyers -- Metabolomics data analysis, visualization, and integration / Lloyd W. Sumner, Ewa Urbanczyk-Wochniak, and Corey D. Broeckling -- KEGG bioinformatics resource for plant genomics research / Ali Masoudi-Nejad ... [et al.] -- International Crop Information System for germplasms data management / Arllet Portugal ... [et al.] -- Automated discovery of single nucleotide polymorphism and simple sequence repeat molecular genetic markers / Jacqueline Batley, Erica Jewell, and David Edwards -- Methods for gene ontology annotation / Emily Dimmer ... [et al.] -- Gene structure annotation at PlantGDB / Volker Brendel -- An introduction to BioPerl / Jason E. Stajich.

Recent advances in plant transformation -- Engineering the plastid genome of nicotiana sylvestris, a diploid model species for plastid genetics -- Homologous recombination in plants : An antireview -- Chromosome painting for plant biotechnology -- Plant B chromosomes -- Telomere truncation in plants -- Engineered plant minichromosomes -- Method for bxb1-mediated site-specific integration in planta -- Targeted mutagenesis in arabidopsis using zinc-finger nucleases -- Vectors and methods for hairpin RNA and artificial microRNA-mediated gene silencing in plants -- Recombinant protein expression in nicotiana -- Chromosome analysis and sorting using flow cytometry -- Super-stretched pachytene chromosomes for plant molecular cytogenetic mapping -- Cytological dissection of the triticeae chromosomes by the gametocidal system -- Development and use of oat-maize chromosome additions and radiation hybrids -- Enhancer trapping in plants -- Chromatin beacons : Global sampling of chromatin physical properties using chromatin charting lines -- Transposable elements as catalysts for chromosome rearrangements.

Growth protocols for model plants in developmental biology / Lars Hennig -- Grafting as a research tool / Colin G.N. Turnbull -- Virus-induced gene silencing as a reverse genetics tool to study gene function / Steven Bernacki ... [et al.] -- The CRE/lox system as a tool for developmental studies at the cell and tissue level / Guy Wachsman and Renze Heidstra -- Inducible gene expression systems for plants / Lorenzo Borghi -- Trichome development in Arabidopsis / Joachim F. Uhrig and Martin Hülskamp -- Phenotyping the development of leaf area in Arabidopsis thaliana / Sarah J. Cookson ... [et al.] -- Analyzing shoot apical meristem development / Cristel C. Carles ... [et al.] -- Analyzing floral meristem development / Elisa Fiume ... [et al.] -- Female gametophytic mutants : diagnosis and characterization / Ronny Völz and Rita Gross-Hardt -- Pollen tube development / Mark A. Johnson and Benedikt Kost -- Analysis of root meristem size development / Serena Perilli and Sabrina Sabatini -- Phenotypic characterization of photomorphogenic responses during plant development / Thomas Kretsch -- Kinematic analysis of cell division and expansion / Bart Rymen ... [et al.] -- Flowering time control / Yvonne Möller-Steinbach, Cristina Alexandre, and Lars Hennig -- mRNA detection by whole mount in situ hybridization (WISH) or sectioned tissue in situ hybridization (SISH) in Arabidopsis / Yvonne Stahl and Rüdiger Simon -- Immunolocalization of proteins in plants / Michael Sauer and Jiří Friml -- Detection of small non-coding RNAs / Tamas Dalmay -- Quantitative real time PCR in plant developmental biology / Vivien Exner -- Luciferase and green fluorescent protein reporter genes as tools to determine protein abundance and intracellular dynamics / András Viczián and Stefan Kircher -- Fluorescence-activated cell sorting in plant developmental biology / Anjali S. Iyer-Pascuzzi and Philip N. Benfey -- Laser microdissection of paraffin-embedded plant tissues for transcript profiling / Robert C. Day -- Utilizing bimolecular fluorescence complementation (BiFC) to assay protein-protein interaction in plants / Nir Ohad and Shaul Yalovsky -- The split luciferase complementation assay / Naohiro Kato and Jason Jones -- Co-immunoprecipitation and protein blots / Erika Isono and Claus Schwechheimer -- Probing protein-protein interactions with FRET-FLIM / Christoph Bücherl ... [et al.] -- Plant chromatin immunoprecipitation / Corina B.R. Villar and Claudia Köhler -- Immunocytological analysis of chromatin in isolated nuclei / Penka Pavlova ... [et al.] -- Bisulphite sequencing of plant genomic DNA / Ernst Aichinger and Claudia Köhler.

Zygotic embryo culture : an overview /Tegan M. Haslam and Edward C. Yeung --In vitro fertilization with rice gametes: production of zygotes and zygote and embryo culture /Takashi Okamoto --Canola zygotic embryo culture /Nicole S. Ramesar-Fortner and Edward C. Yeung --Immature seeds and embryos of Medicago truncatula cultured in vitro /Sergio J. Ochatt --In vitro culture and germination of terrestrial asian orchid seeds /Yung-I. Lee --In vitro culture of coconut (Cocos nucifera L.) zygotic embryos /Florent Engelmann, Bernard Malaurie, and Oulo N'Nan --Immature embryo rescue and culture /Xiuli Shen, Fred G. Gmitter, Jr., and Jude W. Grosser --Chickpea hybridization using in vitro techniques /Nalini Mallikarjuna and Fred J. Muehlbauer --Muskmelon embryo rescue techniques using in vitro embryo culture /Hector Gordon Nunez-Palenius, Rafael Ramirez-Malagon, and Neftali Ochoa-Alejo --Phaseolus immature embryo rescue technology /Pascal Geerts ... [et al.] --Wide crossing in lentil through embryo rescue /Richard Fratini and Maria L. Ruiz --Generation of interspecific hybrids of Trifolium using embryo rescue techniques /Ajoy Kumar Roy, Devendra Ram Malaviya and Pankaj Kaushal --Cryopreservation of embryos : an overview /Florent Engelmann --Cryogenic technologies for the long-term storage of Citrus germplasm /Anna De Carlo, Maurizio Lambardi, and Elif Aylin Ozudogru --Cryopreservation of zygotic embryonic axes and somatic embryos of european chestnut /Ana M. Vieitez, M. Carmen San-Jose and Elena Corredoira --Cryopreservation of Ilex immature zygotic embryos /Luis Mroginski ... [et al.] --Use of zygotic embryos as explants for in vitro propagation : an overview /Mohamed Elhiti and Claudio Stasolla --Somatic embryogenesis and plant regeneration in the culture of Arabidopsis thaliana (L.) heynh. immature zygotic embryos /Malgorzata D. Gaj -- Pine somatic embryogenesis using zygotic embryos as explants /Gerald S. Pullman and Kylie Bucalo --Micropropagation of Phalaenopsis orchids via protocorms and protocorm-like bodies /Kee Yoeup Paek, Eun Joo Hahn, and So Young Park --Genetic transformation protocols using zygotic embryos as explants : an overview /Muhammad Tahir, Ejaz A. Waraich, and Claudio Stasolla --Genetic transformation using maize immature zygotic embryos /Bronwyn Frame ... [et al.] --Biolistic-mediated transformation protocols for maize and pearl millet using pre-cultured immature zygotic embryos and embryogenic tissue /Martha M. O'Kennedy, Hester C. Stark and Nosisa Dube --Agrobacterium tumefaciens-mediated genetic transformation of cereals using immature embryos /Ashok K. Shrawat and Allen G. Good.

Arabidopsis embryogenesis / Soomin Park and John J. Harada -- Maize embryogenesis / Pilar Fontanet and Carlos M. Vicient -- Spruce embryogenesis / Sara von Arnold and David Clapham -- In vitro fertilization with isolated higher plant gametes / Erhard Kranz, Yoichiro Hoshino, and Takashi Okamoto -- In vitro culture of Arabidopsis embryos / Michael Sauer and Jiří Friml -- Culture and time-lapse tracking of barley microspore-derived embryos / Simone de F. Maraschin ... [et al.] -- Isolation of embryo-specific mutants in Arabidopsis : plant transformation / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Isolation of embryo-specific mutants in Arabidopsis : genetic and phenotypic analysis / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Laser-capture microdissection to study global transcriptional changes during plant embryogenesis / Stuart A. Casson, Matthew W.B. Spencer, and Keith Lindsey -- Promoter trapping system to study embryogenesis / Robert Blanvillain and Patrick Gallois -- Visualization of auxin gradients in embryogenesis / Michael Sauer and Jiří Friml -- Intercellular trafficking of macromolecules during embryogenesis / Insoon Kim and Patricia C. Zambryski -- Immunolocalization of proteins in somatic embryos : applications for studies on the cytoskeleton / Andrei P. Smertenko and Patrick J. Hussey -- Detection of programmed cell death in plant embryos / Lada H. Filonova, María F. Suárez, and Peter V. Bozhkov.

Paleopolyploidy and its impact on the structure and function of modern plant genomes / A.H. Paterson -- Genomic history and gene family evolution in angiosperms: challenges and opportunities / J. Sampedro, D. Cosgrove -- The evolutionary position of subfunctionalization, downgraded / M. Freeling -- Grass genome structure and evolution / J. Messing, J.L. Bennetzen -- Phylogenetic insights into the pace and pattern of plant genome size evolution / C.E. Grover, J.S. Hawkins, J.F. Wendel -- Plant transposable elements / J.M. Deragon, J.M. Casacuberta, O. Panaud -- Plant sex chromosomes / D. Charlesworth -- Plant centromeres / J.C. Lamb ... [et al.] -- MiRNAs in the plant genome: all things great and small / B.C. Meyers, P.J. Green, C. Lu -- Recent insights into the evolution of genetic diversity of maize / A. Rafalski, S. Tingey -- The rice genome structure as a trail from the past to beyond / T. Sasaki.

Role of model plant species / Richard Flavell -- New technologies for ultra-high throughput genotyping in plants / Nikki Appleby, David Edwards, and Jacqueline Batley -- Genetic maps and the use of synteny / Chris Duran, David Edwards, and Jacqueline Batley -- A simple TAE-based method to generate large insert BAC libraries from plant species / Bu-Jun Shi, J. Perry Gustafson, and Peter Langridge -- Transcript profiling and expression level mapping / Elena Potokina, Arnis Druka, and Michael J. Kearsey -- Methods for functional proteomic analyses / Christof Rampitsch and Natalia V. Bykova -- Stable transformation of plants / Huw D. Jones and Caroline A. Sparks -- Transient transformation of plants / Huw D. Jones, Angela Doherty, and Caroline A. Sparks -- Bridging the gene-to-function knowledge gap through functional genomics / Stephen J. Robinson and Isobel A.P. Parkin -- Heterologous and cell-free protein expression systems / Naser Farrokhi ... [et al.] -- Functional genomics and structural biology in the definition of gene function / Maria Hrmova and Geoffrey B. Fincher -- In situ analysis of gene expression in plants / Sinéad Drea ... [et al.] -- Plant and crop databases / David E. Matthews, Gerard R. Lazo, and Olin D. Anderson -- Plant genome annotation methods / Shu Ouyang ... [et al.] -- Molecular plant breeding : methodology and achievements / Rajeev K. Varshney ... [et l.] -- Practical delivery of genes to the marketplace / David A. Fischhoff and Molly N. Cline -- Ecological genomics of natural plant populations : the Israeli perspective / Eviatar Nevo -- Genome sequencing approaches and successes / Michael Imelfort ... [et al.]

1. Using reverse genetics to develop small knockout collections for specific biological questions / J. Northey and P. McCourt -- 2. Visualizing auxin transport routes in Arabidopsis leaf primordial / Danielle Marcos and Thomas Berleth -- 3. Gene expression analyses for elucidating mechanisms of hormonal action in plants / George W. Bassel and Nicholas J. Provart -- 4. Measurement of plant hormones by liquid chromatography-mass spectrometry / Stacey J. Owen and Suzanne R. Abrams -- 5. Measurement of abscisic acid and gibberellins by gas chromatography/mass spectrometry / Masanori Okamoto ... [et al.] -- 6. Pull-down assays for plant hormone research / Stefab Kepinski -- 7. Binding assays for brassinosteroid receptors / Ana Caño-Delgado and Zhi-Yong Wang -- 8. Binding assays for abscisic acid receptors / Fawzi A. Razem and Robert D. Hill -- 9. Cytokinin sensing systems using microorganisms / Masayuki Higuchi, Tatsuo Kakimoto and Takeshi Mizuno -- 10. Hormone-binding assay using living bacteria expressing eukaryotic receptors / Georgy A. Romanov and S.N. Lomin -- 11. Discovery of plant microRNAs and short-interfering RNAs by deep parallel sequencing / Padmanabhan Chellappan and Hailing Jin -- 12. The use of chemical genomics to investigate pathways intersecting auxin-dependent responses and endomembrane trafficking in Arabidopsis thaliana / Lorena Norambuena, Glenn R. Hicks and Natasha V. Raikhel.

v. 1. The background.

Total protein extraction with TCA-acetone / Valérie Méchin, Catherine Damerval, and Michel Zivy -- Phenol extraction of proteins for proteomic studies of recalcitrant plant tissues / Mireille Faurobert, Esther Pelpoir, and Jamila Chaïb -- Protein extraction from cereal seeds / Gérard Branlard and Emmanuelle Blancel -- Protein extraction from xylem and phloem sap / Julia Kehr and Martijn Rep -- Protein extraction from woody plants / Christophe Plomion and Céline Lalanne -- Isolation of chloroplast proteins from Arabidopsis thaliana for proteome analysis / Klaas J. van Wijk, Jean-Benoit Peltier, and Lisa Giacomelli -- Isolation and subfractionation of plant mitochondria for proteomic analysis / Holger Eubel, Joshua L. Heazlewood, and A. Harvey Millar -- Extraction of nuclear proteins from root meristematic cells / Fernando González-Camacho and Francisco Javier Medina -- Isolation of nuclear proteins / Setsuko Komatsu -- Isolation of cell wall proteins from Medicago sativa stems / Bonnie S. Watson and Lloyd W. Sumner -- Plant plasma membrane protein extraction and solubilization for proteomic analysis / Véronique Santoni -- Detergents and chaotropes for protein solubilization before two-dimensional electrophoresis / Thierry Rabilloud ... [et al.] -- Two-dimensional electrophoresis for plant proteomics / Walter Weiss and Angelika Görg -- Visible and fluorescent staining of two-dimensional gels / François Chevalier, Valérie Rofidal, and Michel Rossignol -- Two-dimensional differential in-gel electrophoresis (DIGE) of leaf and roots of Lycopersicon esculentum / Matthew Keeler ... [et al.] -- Quantitative analysis of 2D gels / Michel Zivy -- Multivariate data analysis of proteome data / Kåre Engkilde, Susanne Jacobsen, and Ib Søndergaard -- Edman sequencing of plant proteins from 2D gels / Setsuko Komatsu -- Peptide mass fingerprinting: identification of proteins by MALDI-TOF / Nicolas Sommerer, Delphine Centeno, and Michel Rossignol -- Protein identification using nano liquid chromatography-tandem mass spectrometry / Luc Negroni -- Two-dimensional nanoflow liquid chromatography-tandem mass spectrometry of proteins extracted from rice leaves and roots / Linda Breci and Paul A. Haynes -- Separation, identification, and profiling of membrane proteins by GFC/IEC/SDS-PAGE and MALDI TOF MS / Wojciech Szponarski ... [et al.] -- The PROTICdb database for 2-DE proteomics / Olivier Langella, Michel Zivy, and Johann Joets -- Identification of phosphorylated proteins / Maria V. Turkina and Alexander V. Vener -- Plant proteomics and glycosylation / Anne-Catherine Fitchette ... [et al.] -- Blue-native gel electrophoresis for the characterization of protein complexes in plants / Jesco Heinemeyer, Dagmar Lewejohann, and Hans-Peter Braun -- Electroelution of intact proteins from SDS-PAGE gels and their subsequent MALDI-TOF MS analysis / Zhentian Lei ... [et al.] -- Generation of plant protein microarrays and investigation of antigen-antibody interactions / Birgit Kersten and Tanja Feilner -- Phosphorylation studies using plant protein microarrays / Tanja Feilner and Birgit Kersten.

Analysis of High-Throughput Sequencing Data / Shrinivasrao P. Mane, Thero Modise, Bruno W. Sobral -- Identification of Plant microRNAs Using Expressed Sequence Tag Analysis / Taylor P. Frazier, Baohong Zhang -- Microarray Data Analysis / Saroj K. Mohapatra, Arjun Krishnan -- Setting Up Reverse Transcription Quantitative-PCR Experiments / Madana M. Ambavaram, Andy Pereira -- Virus-Induced Gene Silencing in Nicotiana benthamiana and Other Plant Species / Andrew Hayward, Meenu Padmanabhan, S. P. Dinesh-Kumar -- Agroinoculation and Agroinfiltration: Simple Tools for Complex Gene Function Analyses / Zarir Vaghchhipawala, Clemencia M. Rojas, Muthappa Senthil-Kumar, Kirankumar S. Mysore -- Full-Length cDNA Overexpressor Gene Hunting System (FOX Hunting System) / Mieko Higuchi, Youichi Kondou, Takanari Ichikawa, Minami Matsui -- Activation Tagging with En/Spm-I /dSpm Transposons in Arabidopsis / Nayelli Marsch-Martínez, Andy Pereira -- Activation Tagging and Insertional Mutagenesis in Barley / Michael A. Ayliffe, Anthony J. Pryor -- Methods for Rice Phenomics Studies / Chyr-Guan Chern, Ming-Jen Fan, Sheng-Chung Huang, Su-May Yu, Fu-Jin Wei, Cheng-Chieh Wu, Arunee Trisiriroj, Ming-Hsing Lai, Shu Chen, Yue-Ie C. Hsing -- Development of an Efficient Inverse PCR Method for Isolating Gene Tags from T-DNA Insertional Mutants in Rice / Sung-Ryul Kim, Jong-Seong Jeon, Gynheung An -- Transposon Insertional Mutagenesis in Rice / Narayana M. Upadhyaya, Qian-Hao Zhu, Ramesh S. Bhat -- Reverse Genetics in Medicago truncatula Using Tnt1 Insertion Mutants / Xiaofei Cheng, Jiangqi Wen, Million Tadege, Pascal Ratet, Kirankumar S. Mysore -- Screening Arabidopsis Genotypes for Drought Stress Resistance / Amal Harb, Andy Pereira -- Protein Tagging for Chromatin Immunoprecipitation from Arabidopsis / Stefan Folter -- Yeast One-Hybrid Screens for Detection of Transcription Factor DNA Interactions / Pieter B. Ouwerkerk, Annemarie H. Meijer -- Plant Metabolomics by GC-MS and Differential Analysis / Joel L. Shuman, Diego F. Cortes, Jenny M. Armenta, Revonda M. Pokrzywa, Pedro Mendes, Vladimir Shulaev -- Gramene Database: A Hub for Comparative Plant Genomics / Pankaj Jaiswal.

Multiple dimensions in plant signal transduction : an overview / Jorge J. Casal -- Phenotyping of Arabidopsis mutants for developmental effects of gene deletions / Cordelia Bolle -- Phenotyping of abiotic responses and hormone treatment in Arabidopsis / Cordelia Bolle -- Accurate real-time reverse transcription quantitative PCR / Marco Klatte and Petra Bauer -- Probing spatio-temporal intracellular calcium variations in plants / Axel Mithöfer, Christian Mazars, and Massimo E. Maffei -- Dynamic redox measurements with redox-sensitive GFP in plants by confocal laser scanning microscopy / Andreas J. Meyer and Thorsten Brach -- Imaging reactive oxygen species in vivo / Steven M. Driever ... [et al.] -- Identification of thioredoxin targeted proteins using thioredoxin single cysteine mutant-immobilized resin / Ken Motohashi, Patrick G.N. Romano, and Toru Hisabori -- Determination of in vivo protein phosphorylation in photosynthetic membranes / Julia P. Vainonen, Alexander V. Vener, and Eva-Mari Aro -- Examining protein stability and its relevance for plant growth and development / Claus Schwechheimer ... [et al.] -- Probing circadian rhythms in Chlamydomonas rheinhardtii by functional proteomics / Volker Wagner and Maria Mittag -- Bimolecular fluorescence complementation (BiFC) to study protein-protein interactions in living plant cells / Katia Schütze, Klaus Harter, and Christina Chaban -- Fluorescence cross-correlation spectroscopy of plant proteins / Hideki Muto, Masataka Kinjo, and Kotaro T. Yamamoto -- The determination of protein-protein interactions by the mating-based split-ubiquitin-system (mbSUS) / Christopher Grefen, Petr Obrdlik, and Klaus Harter -- Functional complementation of yeast mutants to study plant signalling pathways / Norbert Mehlmer, Elisabeth Scheikl-Pourkhalil, and Markus Teige -- Phosphatase activities analyzed by in vivo expressions / Alois Schweighofer, Zahra Ayatollahi, and Irute Meskiene -- Chromatin immunoprecipitation experiments to investigate in vivo binding of Arabidopsis transcription factors to target sequences / Benjamin Fode and Christiane Gatz -- Fluorescence-based electrophoretic mobility shift assay in the analysis of DNA-binding proteins / Sebastian Steiner and Thomas Pfannschmidt -- Analysis of plant regulatory DNA sequences by the yeast-one-hybrid assay / Dierk Wanke and Klaus Harter -- Analysis of plant regulatory DNA sequences by transient protoplast assays and computer aided sequence evaluation / Kenneth W. Berendzen, Klaus Harter, and Dierk Wanke -- RNA protein interaction mediating post-transcriptional regulation in the circadian system / Jan C. Schöning and Dorothee Staiger.

The use of protoplasts to study innate immune responses / Ping He, Libo Shan, and Jen Sheen -- Marker-exchange mutagenesis and complementation strategies for the gram-negative bacteria Xanthomonas oryzae pv. oryzae / Sang-Won Lee and Pamela C. Ronald -- Whole-genome analysis to identify type III-secreted effectors / Boris A. Vinatzer and Jean T. Greenberg -- In planta expression of oomycete and fungal genes / Thirumala-Devi Kanneganti, Edgar Huitema, and Sophien Kamoun -- Use of nipponbare bac clones for physical mapping of an R gene locus in rice / Jong-Seong Jeon and Pamela C. Ronald -- Agrobacterium-mediated transformation to create an insertion library in magnaporthe grisea / Sara L.Tucker and Marc J. Orbach -- Identification of components in disease-resistance signaling in arabidopsis by map-based cloning / Yuelin Zhang, Jane Glazebrook, and Xin Li -- Yeast two-hybrid approaches to dissecting the plant defense response / Mawsheng Chern, Todd Richter, and Pamela C. Ronald -- Use of rolling-circle amplification for large-scale yeast two-hybrid analyses / Xiaodong Ding, Yan Zhang, and Wen-Yuan Song -- Preparative denaturing isoelectric focusing for enhancing sensitivity of proteomic studies / Antonio Serna-Sanz, Greg Rairdan, and Scott C. Peck --Use of massively parallel signature sequencing to study genes expressed during the plant defense response / Blake C. Meyers, Christian D. Haudenschild, and Kalyan Vemaraju -- Use of microarray analysis to dissect the plant defense response / Jane Glazebrook -- Use of robust long-serial analysis of gene expression to identify novel fungal and plant genes involved in host-pathogen interactions / Malali Gowda ... [et al.] -- Analysis of gene function in rice through virus-induced gene silencing / Xin Shun Ding, C. Srinivasa Rao, and Richard S. Nelson -- Use of RNA interference to dissect defense-signaling pathways in rice / Chuansheng Mei, Xiangjun Zhou, and Yinong Yang -- Virus-induced gene silencing in plant roots / Isgouhi Kaloshian -- Methods for engineering resistance to plant viruses / Mysore R. Sudarshana, Gourgopal Roy, and Bryce W. Falk -- Development of genetically engineered resistant papaya for papaya ringspot virus in a timely manner: a comprehensive and successful approach / Savarni Tripathi, Jon Suzuki, and Dennis. Gonsalves.

Plant vaccines: an immunological perspective / D.C. Hooper -- Display of peptides on the surface of tobacco mosaic virus particles / M.L. Smith ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality / S. Chebolu and H. Daniell -- Production of antibodies in plants: approaches and perspectives / K. Ko, R. Brodzik and Z. Steplewski -- Plant production of veterinary vaccines and therapeutics / R.W. Hammond and L.G. Nemchinov -- Plant-based oral vaccines: results of human trials / C.O. Tacket.

v. 1. General principles -- v. 2. The head and neck, part 1 -- v. 3. The head and neck, part 2 -- v. 4. Pediatric plastic surgery -- v. 5. Tumors of the head, neck, and skin -- v. 6. Trunk and lower extremity -- v. 7. The hand and upper limb, part 1 -- v. 8. The hand and upper limb, part 2.

Ch. 1Introduction: Plasticity in the visual system: from genes to circuits --Pt. IRetinal and thalamic plasticity --Ch. 2Synaptic plasticity and structural remodeling of rod and cone cells --Ch. 3Retinal remodeling: circuitry revisions triggered by photoreceptor degeneration --Ch. 4Retinal plasticity and interactive cellular remodeling in retinal detachment and reattachment --Ch. 5Experience-dependent rewiring of retinal circuitry: involvement of immediate early genes --Ch. 6Attentional activation of cortico-reticulo-thalamic pathways revealed by Fos imaging --Pt. IICortical plasticity --Ch. 7Neuromodulatory transmitters in sensory processing and plasticity in the primary visual cortex --Ch. 8Critical calcium-regulated biochemical and gene expression programs involved in experience-dependent plasticity --Ch. 9The molecular biology of sensory map plasticity in adult mammals --Ch. 10Plasticity of retinotopic maps in visual cortex of cats and monkeys after lesions of the retina or primary visual cortex --Ch. 11Intra-cortical inhibition in the regulation of receptive field properties and neural plasticity in the primary visual cortex --Ch. 12Plasticity in V1 induced by perceptual learning --Ch. 13Investigating higher order cognitive functions in the dorsal (magnocellular) stream of visual processing --Ch. 14Dopamine-dependent associative learning of workload-predicting cues in the temporal lobe of the monkey --Pt. IIITheoretical considerations --Ch. 15Linking visual development and learning to information processing: pre-attentive and attentive brain dynamics --Ch. 16Conclusion: a unified theoretical framework for plasticity in visual circuitry.

Platelet physiology / Martin Quinn -- Platelet integrins and signaling / Karlheinz Peter -- Platelet adhesion / Brian Savage and Zaverio M. Ruggeri -- Structure-function of the platelet cytoskeleton / Elaine L. Bearer -- Platelets and inflammation / Meinrad Gawaz -- Platelet signal-dependent protein synthesis / Stephan Lindemann ... [et al.] -- Phosphoproteomics of human platelets / Katrin Marcus and Helmut E. Meyer -- Platelet function studies / Dermot Cox -- Platelet function under flow / José A. López, Ian del Conde, and Jing-Fei Dong -- Pharmacodynamics of GPIIb-IIIa receptor blockade / Lisa K. Jennings and Melanie M. White -- Prostanoid generation in platelet function: assessment and clinical relevance / Bianca Rocca and Carlo Patrono -- Platelets and prothrombin / Michael Kalafatis ... [et al.] -- Markers of platelet activation and granule secretion / Alan D. Michelson and Mark I. Furman -- Genomic and proteomic analysis of platelets: clinical applications / Andrew Maree and James McRedmond -- Antiplatelet agents / Jacqueline Saw and David J. Moliterno -- Assessing platelet function in clinical trials / Neil Kleiman.

v. 1. Functional assays -- v. 2. Perspectives and techniques.

Pathophysiology of signs and symptoms of coma -- Examination of the comatose patient -- Structural causes of stupor and coma -- Specific causes of structural coma -- Multifocal, diffuse, and metabolic brain diseases causing delirium, stupor, or coma -- Psychogenic unresponsiveness -- Approach to management of the unconscious patient -- Brain death -- Prognosis in coma and related disorders of consciousness, mechanisms underlying outcomes, and ethical considerations.

History of infusion therapy -- Minimizing risk and improving performance -- Nursing role and responsibilities -- Application of infusion nurses society standards of practice -- Anatomy and physiology applied to infusion therapy -- Laboratory tests and values -- Fluid and electrolyte balance -- Principles of parenteral fluid administration -- Complications and interventions -- Evidence-based infusion practice -- Infusion equipment and safety -- Peripheral infusion therapy techniques -- Short peripheral access -- Central venous access -- Alternate access -- Parenteral nutrition -- Transfusion therapy -- Pharmacology applied to infusion therapy -- Antineoplastic therapy -- Pain management -- Pediatric intravenous therapy -- Infusion therapy in an older adult patient -- Infusion therapy in alternate clinical settings: cost factors and treatment modalities -- The future of infusion nursing.

Moral casuistry, medical research, and innovation, and rabbinical decision-making /Mark J. Cherry and Ana Smith Iltis --SECTION I PLURALISTIC MORAL CASUISTRY --Notes toward a pluralistic professional medical ethics /Laurence B. Mccullough --Ethics and a deep moral ambiguity /Kevin WM. Wildes --Moral judgement and the ideal intuitor : dealing with moral confusion and moral disagreement /Janet Malek --Casuistry naturalized /Maureen Kelley --SECTION II JEWISH MEDICAL ETHICS --Intuitionism, divine commands, and natural law /Andrew Lustig --In case : Contingency and particularity in bioethics : Discursive method and clinical midrash brief notes on a lesson from my teacher Baruch Brody /Laurie Zoloth --The Euthyphyro's dilemma reconsidered : a variation on a theme from Brody on halakhic method /H. Tristram Englehardt, Jr. --SECTION III BIOMEDICAL PUBLIC POLICY --The Good (philosophy), the bad (public policy) and the ugliness of blaming families for ineffectual treatments /Robert M. Arnold --Is withholding artificial nutrition and hydration from PVS Patients active euthanasia? /Loretta M. Kopelman --SECTION IV CRITICAL APPLICATION AND ANALYSIS --The virtue of integrity in Baruch Brody's moral framework /J. CLint Parker --Paradigms, practices and politics : ethics and the language of the human embryo transfer/donation/rescue/adopition /Sarah-Vaughan Brakman -- Brody on Passive and Active Euthanasia /F. M. Kamm --SECTION V RESPONSE TO FRIENDS AND CRITICISMS --Comments on the Essays /Baruch A. Brody.

The advent of type-specific antipneumococcal serotherapy -- A "specific" specific and the turbid age of applied immunology -- Fundamental tensions: clinical "proof" and clinical resistance -- The Massachusetts experiment and New (York) tensions -- The new standard, the new deal, and the pneumonia control programs -- Histology of a revolution -- A "modern" revolution: the limits and uses of controlled clinical trials -- The dismantling of pneumonia as a public health concern.

History / Marnae C. Ergil -- Fundamental theory of Chinese medicine / Kevin V. Ergil -- Diagnosis in Chinese medicine / Kevin V. Ergil -- Acupuncture / Marnae C. Ergil -- Tui na / Michael McCarthy and Kevin V. Ergil -- Traditional Chinese pharmacotherapy / Simon Becker -- Chinese dietetic / Mary Garvey -- Qi gong / Anne Reinard and Yves Réquéna -- Tai ji quan / Douglas Wile -- Acupuncture research : an overview / Stephen Birch.

Includes skull and oral tumor images

Examination -- Imaging and patient position -- Parasternal long-axis view -- Parasternal short-axis view -- Apical windows -- Suprasternal window -- Subcostal window -- M-mode and Doppler echocardiography -- M-mode -- Doppler -- Cardiac abnormalities -- Valvular heart disease -- Coronary heart disease -- Cardiomyopathies -- Prosthetic valves -- Carditis -- Septal defects -- Hypertensive heart diseases -- Intracardiac masses.

At a glance -- General anatomy -- Bones -- Sutures, joints, ligaments -- Muscles -- Tendon sheaths and bursae -- Alimentary system -- Respiratory system -- Urogenital system -- Abdominopelvic cavity -- Endocrine glands -- Heart -- Arteries -- Veins -- Lymphoid system -- Meninges -- Spinal cord -- Brain -- Cranial nerves -- Spinal nerves -- Autonomic nervous system -- Sense organs -- Skin and its appendages.

Anatomy / M. Grueb -- Optical system and physiology / M. Grueb -- Lids / M. Grueb -- Lacrimal apparatus / J. Mielke -- Orbit / J.M. Rohrbach, D. Holland -- Strabismus / H.-S. Walter -- Conjunctiva / J. M. Rohrbach -- Cornea / J. Mielke -- Sclera / T. Schlote -- Choroid and iris / T. Schlote -- Lens / J.M. Rohrbach -- Glaucoma / M. Grueb -- Retina and vitreous body / F. Gelisken -- Macula / U. Schneider -- Optic nerve and optic pathway / P. Weckerle -- Drug-induced ocular side-effects / T. Schlote -- Eye diseases in developing countries / J. Mielke.

White lesions -- Red lesions -- Black and brown lesions -- Vesiculobullous lesions -- Ulcerative lesions -- Papillary lesions -- Gingival enlargement -- Soft-tissue tumors -- Soft-tissue cysts -- Bone swellings -- Neck swellings -- Lip lesions.

v. 1. Head and neck -- v. 2. Thorax, heart, abdomen, and pelvis -- v. 3. Spine, extremities, joints.

In this fully up-to-date Second Edition, experts in Chinese medicine explain how traditional Chinese tongue diagnosis can be used in daily practice to complement conventional Western methods. The guide begins with a brief introduction to the history, anatomy, physiology, and methodology of tongue diagnosis followed by basic techniques and systematic procedures for identifying the manifold individual characteristics of the tongue's shape and its many modifications. Full-color photographs of tongues then demonstrate a variety of clinical scenarios to help readers develop a holistic approach to diagnosis.

Neck pain and shooting arm pain -- Shoulder pain -- Elbow pain -- Wrist and hand pain -- Low back pain, hip pain, and shooting leg pain -- Knee pain -- Ankle pain -- Foot pain.

Acid-base and electrolyte disorders / Mildred Lam -- Cardiovascular system / Stephen N. Adler -- Endocrine/metabolic system / Thomas A. Murphy -- Gastrointestinal and hepatic systems / Wendell K. Clarkston, Patricia Sanchez, and Bruce R. Bacon -- Genitourinary system / Mildred Lam -- Hematologic system / Kyung-Whan Min -- Infectious disease / Debra Adler-Klein -- Integument / Dianne B. Gasbarra -- Musculoskeletal system / Dianne B. Gasbarra -- Nervous system / Stephen N. Adler -- Respiratory system / Dianne B. Gasbarra -- Human immunodeficiency virus infection / Debra Adler-Klein.

History and physical examination -- Laboratory assessment -- Arthrocentesis and synovial fluid analysis -- Imaging techniques -- Monarticular joint disease -- Polyarticular joint disease -- Regional rheumatic pain syndromes -- Fibromyalgia and diffuse pain syndromes -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Psoriatic arthritis -- Ankylosing spondylitis -- Reactive and enteropathic arthritis -- Osteoarthritis -- Calcium pyrophosphate dehydrate, hydroxyapatite, and miscellaneous crystals -- Infectious disorders -- Systemic lupus erythematosus -- Antiphospholipid syndrome -- Systemic sclerosis -- Idiopathic inflammatory myopathies -- Metabolic myopathies -- Sjogren's syndrome -- Vasculitides -- Behcet's syndrome -- Adult Still's disease -- Autoinflammatory disorders/periodic syndromes -- Less common arthropathies -- Complex regional pain syndrome -- Osteonecrosis -- Paget's disease -- Osteoporosis -- Therapeutic injection -- Nonsteroidal anti-inflammatory drugs -- Glucocorticoids -- Operative treatment -- Complementary and alternative therapies.

Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.

Enzymes in poly(ADP-ribose) metabolism / Ralph G. Meyer ... [et al.] -- PARP-2: structure-function relationship / Valørie Schreiber ... [et al.] -- Targeting the poly(ADP-ribose) glycohydrolase (PARG) gene in mammals / Ulrich Cortes and Zhao-Qi Wang -- DNA damage signaling through poly(ADP-ribose) / Maria Malanga and Felix R. Althaus -- Roles of poly(ADP-ribose) metabolism in the regulation of centrosome duplication and in the maintenance of neuronal integrity / Masanao Miwa ... [et al.] -- Functional interactions of PARP-1 with p53 / Rafael Alvarez-Gonzalez ... [et al.] -- Dynamic interaction between PARP-1, PCNA and p21waf1/cip1 / Ennio Prosperi and A. Ivana Scovassi -- Parp-1 as novel coactivator of NF-kB in inflammatory disorders / Paul O. Hassa and Michael O. Hottiger -- PARP and epigenetic regulation / Paola Caiafa -- PARP and the release of apoptosis-inducing factor from mitochondria / Suk Jin Hong, Ted M. Dawson and Valina L. Dawson -- Genome degradation by DNAS1L3 endonuclease: a key PARP-1-regulated event in apoptosis / A. Hamid Boulares, Alexander G. Yakovlev and Mark E. Smulson --NAD-metabolism and regulatory functions / Mathias Ziegler -- PARP-1 and the shape of cell death / Laszlø Virøg -- Poly(ADP-ribose) polymerase (PARP) and excitotoxicity / Domenico E. Pellegrini-Giampietro, Alberto Chiarugi and Flavio Moroni -- Poly(ADP-ribose) polymerase and ischemia-reperfusion injury / Prabal K. Chatterjee and Christoph Thiemermann -- Role of poly(ADP-ribose) polymerase activation in the pathogenesis of inflammation and circulatory shock / Csaba Szabø -- Role of poly-ADP-ribosylation in cancer development / Mitsuko Masutani ... [et al.] -- PARP inhibitors and cancer therapy / Nicola J. Curtin -- Poly(ADP-ribosyl)ation and aging / Sascha Beneke and Alexander Bürkle.

Polyamine structure and synthetic analogs / Patrick M. Woster -- Acute increases in intracellular putrescine lead to the increase in steady-state levels of c-fos, c-jun, RING3, and Id-1 mRNAs / Allan A. Ancheta, Leo Hawel III, and Craig V. Byus -- Polyamine-dependent early cellular signals and cell proliferation / Stina M. Oredsson -- Cellular signals mediating growth arrest after polyamine depletion / Jian-Ying Wang -- Role of polyamines in the regulation of chromatin acetylation / Cheryl A. Hobbs and Susan K. Gilmour -- Role of polyamines in regulation of sequence-specific DNA binding activity / Sripriya Venkiteswaran, Thresia Thomas, and T.J. Thomas -- Polyamine metabolism and the hypertrophic heart / Lisa M. Shantz and Emanuele Giordano -- Influence of polyamines on breast cancer biology / Andrea Manni -- Polyamines in regulation of prostatic cell growth / Raymond G. Schipper ... [et al.] --Polyamines and cytoskeletal regulation during intestinal epithelial restitution / Ramesh M. Ray and Leonard R. Johnson -- Regulation of Kv channel activity and intercellular junctions by polyamines in intestinal epithelial cells / Jaladanki N. Rao and Jian-Ying Wang -- Polyamine block of Kir channels: toward a molecular picture / Harley T. Kurata and Colin G. Nichols -- Regulation of ornithine decarboxylase expression / Lo Persson -- Evidence for a multistep model for eukaryotic polyamine transport / Richard Poulin ... [et al.] -- Bacterial and eukaryotic transport systems / Kazuei Igarashi and Keiko Kashiwagi -- Regulation of S-adenosylmethionine decarboxylase / Colin Hanfrey -- Genetic engineering of polyamine catabolism in transgenic mice and rats / Juhani Jänne ... [et al.].Polyamines in kidney biology / Joseph Satriano -- Polyamines in pulmonary vascular biology / Jack W. Olson and Mark N. Gillespie -- Recent advances in the understanding of mammalian polyamine catabolism: the regulation and potential role of polyamine catabolism in drug response and disease processes / Robert A. Casero, Jr. ... [et al.] -- Cellular signaling and polyamines in the control of apoptosis in intestinal epithelial cells / Leonard R. Johnson and Ramesh M. Ray -- The role of ornithine decarboxylase in Myc-induced tumorigenesis / Jonas A. Nilsson and John L. Cleveland -- Protective effect of polyamines on NSAID-induced injury and apoptosis / Heather M. Wallace and Alun Hughes -- Role of polyamines in the control of the immune response in the brain / Denis Soulet and Serge Rivest -- Implication of polyamines in apoptosis of immunoresponse cells / Rupesh Chaturvedi and Keith T. Wilson -- Polyamines and cancer / Ajit K. Verma -- Polyamine pools and cancer prevention / Eugene W. Gerner and David E. Stringer --

Part I. Polymers as Biomaterials -- 1. Polysaccharides as Biomaterials / Severian Dumitriu -- 2. Biomimetics / Weiyuan John Kao -- 3. Silicones for Pharmaceutical and Biomedical Applications / Haissam S. El-Zaim and John P. Heggers -- 4. Biodegradable Polymers as Drug Carrier Systems / Abraham J. Domb, Neeraj Kumar, Tzviel Sheskin, Alfonso Bentolila, Joram Slager, and Doron Teomim -- 5. Biodegradable Biomaterials Having Nitric Oxide Biological Activity / C.C. Chu -- 6. Hydrogels for Biomedical and Pharmaceutical Applications / Akio Kishida and Yoshito Ikada -- 7. Mucoadhesive Polymers / Andreas Bernkop-Schnürch -- 8. Polymers for Tissue Engineering Scaffolds / Howard W.T. Matthew -- 9. Chitosan: Structure-Properties Relationship and Biomedical Applications / Alain Domard and Monique Domard -- 10. Chitosan-Based Delivery Systems: Physicochemical Properties and Pharmaceutical Applications / Radi Hejazi and Monsoor Amiji -- 11. Immobilization of Active Biopolymers from Cold Plasma-Functionalized Surfaces for the Creation of Molecular Recognition and Molecular Manufacturing Systems / Ferencz Denes and Sorin Manolache -- 12. Advances in Designed Multivalent Bioconjugates with Dendritic Structure / Bogdan Comanita -- 13. Biocompatibility of Elastomers / D.J. Chauvel-Lebret, P. Auroy, and M. Bonnaure-Mallet -- 14. Control of Cell-Biomaterial Interactions / Danielle C. Giliberti, Kyle K. White, and Kay C Dee -- Part II. Medical and Pharmaceutical Applications of Polymers -- 15. Polymeric Systems for Ophthalmic Drug Delivery / O. Felt, S. Einmahl, P. Furrer, V. Baeyens, and R. Gurny -- 16. Dental and Maxillofacial Surgery Applications of Polymers ? A. Bascones, J. M. Vega, N. Olmo, J. Turnay, J.G. Gavilanes, and M.A. Lizarbe -- 17. Biomaterials in Bum and Wound Dressings / Robert L. Sheridan, Jeffrey R. Morgan, and Rashid Mohammad -- 18. Dermocosmetic Applications of Polymeric Biomaterials / P. Corvi Mora and P.G. Baraldi -- 19. Textile-Based Biomaterials for Surgical Applications / C.C. Chu -- 20. Bioabsorbable Polymers for Medical Applications with an Emphasis on Orthopedic Surgery / Pentti U. Rokkanen -- 21. Polymers for Artificial Joints / Naohide Tomita, Kazuya Nagata, and Hiroshi Fujita -- 22. Polymeric Occluders in Tilting Disc Heart Valve Prostheses / G.S. Bhuvaneshwar, A.V. Ramani, and K.B. Chandran -- 23. Blood-Contacting Polymers / T. Avramoglou, J. Jozefonvicz, and M. Jozefowicz -- 24. Surface Modification of Dacron Vascular Grafts: Incorporation of Antithrombin and Mitogenic Properties / Matthew D. Phaneuf Martin J. Bide, William C. Quist, and Frank W. LoGerfo -- 25. Antithrombin-Heparin Complexes / Leslie R. Berry, Maureen Andrew, and Anthony K.C. Chan -- 26. Adhesives for Medical Applications / lain Webster and Peter J. West -- 27. Glucose-Sensitive Hydrogel Membranes / Jin Ho Lee, Jung Ju Kim, and Kinam Park -- 28. Polymeric Micro- and Nanoparticles as Drug Carriers / G. Barratt, G. Couarraze, P. Couvreur, C. Dubernet, E. Fattal, R. Gref, D. Labarre, P. Legrand, G. Ponchel, and C. Vauthier -- 29. Liposomes in Drug Delivery / Yuan-Peng Zhang, Boris Ceh, and Danilo D. Lasic -- 30. Liposomes for Cancer Therapy Applications / Lawrence D. Mayer, Rajesh Krishna, and Marcel B. Bally -- 31. Systemic Cancer Therapy Using Polymer-Based Prodrugs and Progenes / Leonard W. Seymour -- 32. Anticancer Drug Conjugates with Macromolecular Carriers / F. Kratz, A. Warnecke, K. Riebeseel, and P.C.A. Rodrigues -- 33. Enzyme-Prodrug Therapies of Cancer / Richard J. Knox, Roger G. Melton, and Ronit Satchi -- 34. New Lipid/DNA Complexes for Gene Delivery / Kenneth W. Liang and Leaf Huang -- 35. Gene Delivery by Cationic Liposome-DNA Complexes / Nejat Düzgüneş, Sérgio Simões, Pedro Pires, and Maria C. Pedroso de Lima -- 36. Biological Stimulus-Responsive Hydrogels / Takashi Miyata and Tadashi Uragami -- 37. Biocompatible Polymers in Liver-Targeted Gene Delivery Systems / Edwin C. Ouyang, George Y. Wu, and Catherine H. Wu -- 38. Bioartificial Pancreas / Riccardo Calafiore -- 39. Transdermal Delivery of Drugs / B.B. Michniak and A. El-Kattan -- 40. Drug Delivery via Mucosal Routes / Nimit Worakul and Joseph R. Robinson -- 41. Bioadhesive Drug Delivery Systems / A. David Woolfson, R. Karl Malcolm, Paul A. McCarron, and David S. Jones -- 42. Recent Developments in Drug Delivery to the Nervous System -- Dusica Maysinger, Radoslav Savic, Joseph Tam, Christine Allen, and Adi Eisenberg -- 43. Glucose-Mediated Insulin Delivery from Implantable Polymers / Larry R. Brown -- 44. Drug Targeting to the Kidney: The Low-Molecular-Weight Protein Approach / R.F.G. Haverdings, R.J. Kok, M. Haas, F. Moolenaar, D. de Zeeuw, and D.K.F. Meijer.

"In a carefully crafted, multidisciplinary, skillfully focused format, this book covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. It features small, readable monographs that provide a brief description of the evolving role of a particular material, and present topics in highly integrated, well-balanced, authoritatively prepared segments on materials processing and in vitro and in vivo evaluation, complete with case studies"--Provided by publisher.

Polymyalgia Rheumatica and Giant Cell Arteritis - an overview with a focus on important factors contributing to the severity of the disease / Jozef Rovenský, Burkhard F. Leeb, Viera Štvrtinová, Richard Imrich and Juraj Duda -- Polymyalgia Rheumatica, Temporal Arteritis and Occurrence of Malignant Tumors / Jozef Rovenský and Alena Tuchyňová -- Coronary involvement and atherosclerosis in Giant Cell Arteritis / Viera Štvrtinová, Jozef Rovenský and Alena Tuchyňová -- T cells and their role in Polymyalgia Rheumatica and Giant Cell Arteritis / Stanislava Blažíčková and Jozef Rovenský -- Cytokines in Polymyalgia Rheumatica and Giant Cell Arteritis / Jozef Rovenský and Richard Imrich -- Genetic factors in Giant Cell Arteritis and Polymyalgia Rheumatica / Vladimír Bošák -- Polymyalgia rheumatica (PMR) and vascular complications / Viera Štvrtinová, Svetoslav Štvrtina and Jozef Rovenský -- Chronobiology of Polymyalgia Rheumatica and Giant Cell Arteritis / Howard Bird -- Histopathology of Giant Cell (temporal) Arteritis - changes in aorta / Svetoslav Štvrtina and Jozef Rovenský -- Ultrasonography in Polymyalgia Rheumatica and/or Giant Cell Arteritis / Peter Poprac and Jozef Rovenský -- Therapy of Polymyalgia Rheumatica and Giant Cell Arteritis / Jozef Rovenský and Richard Imrich -- Diagnostic Criteria, Treatment, and Monitoring of Polymyalgia Rheumatica/Giant Cell Arteritis / Burkhard F. Leeb, Thomas Nothnagl, Martin Steindl and Bernhard Rintelen.

Polyomaviruses and human diseases / Nasimul Ahsan and Keerti V. Shah -- Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV) / Wendy A. Knowles -- Phylogenomics and molecular evolution of polyomaviruses / Keith A. Crandall ... [et al.] -- Virus receptors and tropism / Aarthi Ashok and Walter J. Atwood -- Serological cross reactivity between polyomavirus capsids / Raphael P. Viscidi and Barbara Clayman -- Molecular genetics of the BK virus / Christopher L. Cubitt -- Serological diagnosis of human polyomavirus infection / Annika Lundstig and Joakim Dillner -- Human polyomavirus JC and BK persistent infection / Kristina Doerries -- Immunity and autoimmunity induced by polyomaviruses / Ole Petter Rekvig, Signy Bendiksen, and Ugo Moens -- The pathobiology of polyomavirus virus infection in man / Parmjeet Randhawa, Abhay Vats, and Ron Shapiro -- Polymoavirus-associated nephropathy in renal transplantation / Hans H. Hirsch ... [et al.] -- BK virus and immunosuppressive agents / Irfan Agha and Daniel C. Brennan -- BK virus infection after non-renal transplantation / Martha Pavlakis, Abdolreza Haririan, and David K. Klassen -- Latent and productive polyomavirus infections of renal allografts / Volker Nickeleit, Harsharan K. Singh, and Michael J. Mihatsch -- Urine cytology findings of polyomavirus infections / Harsharan K. Singh ... [et al.] -- Diagnosis and treatment of BK virus-associated transplant nephropathy / Abhay Vats, Parmjeet S. Randhawa, and Ron Shapiro -- Pharmacotherapeutic options for the management of human polyomaviruses / Julie Roskopf ... [et al.] -- Leflunomide in solid organ transplantation and polyoma virus infection / Michelle A. Josephson ... [et al.] -- JC virus can infect human immune and nervous system progenitor cells / Jean Hou, Pankaj Seth, and Eugene O. Major -- The polyomavirus, JCV, and its involvement in human disease / Kamel Khalili, Jennifer Gordon, and Martyn K. White -- Transforming activities of JC virus early proteins / Richard J. Frisque, Catherine Hofstetter, and Shiva K. Tyagarajan -- Polyomavirus in human cancer development / Winston Lee and Erik Langhoff -- BK virus, JC virus, and simian virus 40 infection in humans and association with human tumors / Giuseppe Barbanti-Brodano ... [et al.] -- Epidemiologic studies of polyomaviruses and cancer / Dana E.M. Rollison.

Polyploidy, aneuploidy, and the evolution of cancer / Lauren M.F. Merlo ... [et al.] -- Molecular mechanisms and function of the spindle checkpoint : a guardian of the chromosome stability / Daisuke Ito and Tomohiro Matsumoto -- Understanding cytokinesis failure / Guillaume Normand and Randall W. King -- DNA damage and polyploidization / Jeremy P.H. Chow and Randy Y.C. Poon -- Role of the p53 family in stabilizing the genome and preventing polyploidization / Flaminia Talos and Ute M. Moll -- Centrosomes, polyploidy, and cancer / Anette Duensing and Stefan Duensing -- Polyploidy : mechanisms and cancer promotion in hematopoietic and other cells / Hao G. Nguyen and Katya Ravid -- Polyploidization of liver cells / Séverine Celton-Morizur and Chantal Desdouets -- Analysis of cellular DNA content by flow and laser scanning cytometry / Zbigniew Darzynkiewicz, H. Dorota Halicka, and Hong Zhao.

Pomegranate phytochemicals / Navindra P. Seeram ... [et al.] -- Antioxidative properties of pomegranate : in vitro studies / Mira Rosenblat and Michael Aviram -- Bioavailability of pomegranate polyphenols / Francisco A. Tomas-Barberan, Navindra P. Seeram, and Juan Carlos Espin -- Protection against cardiovascular disease / Bianca Fuhrman and Michael Aviram -- Protection against stroke / Marva I. Sweeney-Nixon -- Anticancer potential of pomegranate / Shishir Shishodia ... [et al.] -- Molecular mechanisms of chemoprevention of cancer by pomegranate / Deeba Syed ... [et al.] -- Pomegranate and prostate cancer chemoprevention / John T. Leppert and Allan J. Pantuck -- Accessment of estrogenicity of pomegranate in an in vitro bioassay / Diane M. Harris, Emily Besselink, and Navindra P. Seeram -- Absence of significant estrogenic effects in the postmenopausal population / Michelle P. Warren ... [et al.] -- Antimicrobial activities of pomegranate / G.K. Jayaprakasha, P.S. Negi, B.S. Jena -- Commercialization of pomegranates : fresh fruit, beverages, and botanical extracts / Navindra P. Seeram, Yanjun Zhang, and David Heber -- Pomegranates: a botanical perspective / David W. Still -- Postharvest biology and technology of pomegranates / Adel A. Kader.

Antecedents: poverty and early poverty care programs -- Precursors to Medicare and Medicaid -- War on poverty and the genesis of Medicaid -- Hard-to-reach groups -- Redefining health -- Charity care and comprehensive reform under Nixon -- Health planning and community medicine in the 1970s -- Health and welfare reform in the Carter White House -- Block grants and the new federalism -- Recovering the cuts, managed care, and comprehensive reform -- Managed Medicaid, AIDS, and the Clinton health bill.

"Assess the effects of tobacco control programs or public policy changes on smoking behavior."

Thinking like a population geneticist -- Genotype frequencies -- Genetic drift and effective population size -- Population structure and gene flow -- Mutation -- Fundamentals of natural selection -- Further models of natural selection -- Molecular evolution -- Quantitative trait variation and evolution -- The Mendelian basis of quantitative trait variation -- Historical and synthetic topics.

Bridging the divide: population mobility and the emergence of disease. Demographic and epidemiological perspectives of human movement / Yorghos Apostolopoulos and Sevil Sönmez -- Key themes pertinent to migration, health, and disease. Population mobility and the geography of microbial threats / Mary E. Wilson -- Health barriers and inequities for migrants / Elizabeth Ioannidi-Kapolou -- Social networks, social capital, and HIV risks among migrants / Varda Soskolne -- Labor induced migration and disease diffusion. Economic migrants and health vulnerability / Mark N. Lurie -- Military personnel: on the move and vulnerable/AIDS to HIV and other STIs / Stuart J. Kingma and Rodger D. Yeager -- Selling sex in the era of AIDS: mobile sexworkers and STI/HIV risks / Natalya Timoshkina, Anthony P. Lombardo, and Lynn McDonald -- Tracing the diffusion of infectious diseases in the transport sector / Yorghos Apostolopoulos and Sevil Sönmez -- Forced migration: a public health catastrophe. War, refugees, migration, and public health: do infectious diseases matter? / Frederick M. Burkle -- Natural disasters, climate change, and the health of mobile populations / Jonathan D. Mayer -- Leisure migration and health concerns: a paradox or inevitability? Casual sex in the sun makes the holiday: young tourists' perspectives / Eugenia Wickens and Sevil Sönmez -- In search of the exotic: sex tourism and disease risks / Sevil Sönmez, Eugenia Wickens, and Yorghos Apostolopoulos -- New directions in migration health and medicine. Mapping and modeling disease risk among mobile populations / Henry G. Mwambi and Khangelani Zuma -- Ethical and legal issues impacting migrant health / Sana Loue -- Migration in a mobile world: health, population mobility, and emerging disease / Brian D. Gushulak and Douglas W. MacPherson.

Overview --Environmental issues: health care systems, politics and policy, and access --Health administration: systems, policy and management --How politics makes health policy --Poverty and the ethics of equitable access and quality --Critical organization & management elements --The tough work of leadership --Developing networks to deal with complex health care problems --Management information systems for clinicians: design and function --Medical care quality: double track thinking and action --Quality care and academic medical centers: the need for physician --Listening to stakeholders input - interviews, focus groups surveys and direct observation --Lessons learned from hospital mergers --Finance, economics, and insurance --Its not about the money: financing and payment of physician services --Understanding health insurance --Implementing cost control in healthcare --Physicain rewards in the academic medical center --The future --Design and redesign of the health systems' futures --Need for health policy education in the medical curriculum --Healthy communities: past, present, and future.

Part 1. The Transition -- Attire -- The Little Black Book -- Communications -- Surgery Suite Etiquette -- The Clinics -- Rounds -- Difficult People -- Documentation -- Presentations -- The Mortality and Morbidity Conference -- The 80-Hour Week -- The Boards -- The Interview -- Medical - Legal -- HIPAA -- Assorted Affairs -- Part 2. The Transition -- The Mentor's Wrap-Up.

Portal hypertension: a history / Adrian Reuben and Roberto J. Groszmann -- Anatomy and vascular biology of the cells in the portal circulation / Massimo Pinzani and Francesco Vizzutti -- Cell and molecular mechanisms of increased intrahepatic resistance and hemodynamic correlates / Don C. Rockey -- Molecular mechanisms of systemic vasodilation and hyperdynamic circulatory state of cirrhosis / Richard Moreau and Didier Lebrec -- Mechanisms of sodium retention, ascites formation, and renal dysfunction in cirrhosis / Andrés Cárdenas and Pere Ginès -- Hepatic hemodynamics in portal hypertension: compliance, hepatic arterial buffer response, hepatorenal syndrome, and liver regeneration / W. Wayne Lautt and Zhi Ming --Neovascularization, angiogenesis and vascular remodeling in portal hypertension / Manuel Morales-Ruiz and Wladimiro Jiménez -- Mechanisms of cardiopulmonary hemodynamics and dysfunction in portal hypertension / Michael B. Fallon -- Measurement of hepatic venous pressure gradient: methods, interpretation, and pitfalls / G. Pomier-Layrargues and P. Michel Huet -- Evaluation of portal hemodynamics using indicator dilution and noninvasive techniques / Juerg Reichen -- Endoscopic assessment of portal hypertension including variceal pressure measurement: methods, interpretation and pitfalls / Angel Escorsell and Jaime Bosch --Clinical features and natural history of variceal hemorrhage: implications for surveillance and screening / Juan G. Abraldes and Jaime Bosch -- Management strategies for the prophylaxis and treatment of esophageal variceal rupture: an overview / Roberto de Franchis -- Pharmacologic therapy for the management of esophageal varices: biology and utility of available agents / Norman D. Grace and Richard S. Tilson -- Endoscopic treatment for bleeding esophageal varices / John P. Cello -- Surgical therapies for management: surgical shunts and liver transplantation / J. Michael Henderson -- Transjugular intrahepatic portasystemic stent-shunt: technical considerations and clinical utility in the management of variceal hemorrhage / Dhiraj Tripathi ... [et al.] -- Clinical features and management of gastric varices, portal hypertensive gastropathy, and ectopic varices / Charmaine A. Stewart and Patrick S. Kamath -- Ascites: clinical features, diagnosis and natural history / Sakib Karim Khalid and Guadalupe Garcia-Tsao -- Management of ascites / Florence Wong -- Spontaneous bacterial peritonitis and other infections in cirrhosis / Rosa Maria Morillas and Ramon Planas -- Diagnosis and management of hepatorenal syndrome / Kevin Moore -- Pregnancy and portal hypertension / Bimaljit Sandhu and Arun J. Sanyal --Causes and management of portal hypertension in the pediatric population / Frederick C. Ryckman, Maria H. Alonso and Greg Tiao -- Noncirrhotic portal hypertension and portal vein thrombosis / Shiv K. Sarin and Manav Wadhavan -- Hepatic venous outflow obstruction: Budd-Chiari syndrome and Veno-Occlusive disease / Hugo E. Vargas and Thomas D. Boyer -- Pulmonary complications associated with portal hypertension / Karen L. Swanson and Michael J. Krowka -- Health status assessment and economic analyses in cirrhosis and portal hypertension / Jayant A. Talwalkar and W. Ray Kim -- Future treatments: antifibrotic agents, nitric oxide donors, and gene therapy in the treatment of portal hypertension / Meena B. Bansal and Scott L. Friedman.

Anoverview of prevention with people living with HIV /Richard J. Wolitski ... [et al.] --HIV diagnosis and risk behavior /Lance S. Weinhardt --HIV disclosure and safer sex /Jane M. Simoni, David W. Pantalone --HIV-positive gay and bisexual men /Jeffrey T. Parsons --HIV-positive and HCV-positive drug users /Steffanie A. Strathdee, Thomas L. Patterson --Young people living with HIV /Amy Elkavich ... [et al.] --Interventions in community settings /Lisa R. Metsch, Lauren K. Gooden, David W. Purcell --Interventions in clinical settings /Susan M. Kiene, Jeffrey D. Fisher, William A. Fisher --International perspectives /Jonathan Elford ... [et al.]

Walking with hope and dharma : are dogs enlightened? Are Humans? -- The costs and benefits of obliviousness : growing up in the 1950s -- Nine bad things that almost happened, and many more that did : getting to the other side of trauma -- What is the opposite of trauma? : the positive power of transformational grace -- Can there ever be enough me? : narcissism and the positive death of self -- What does it mean to live an "extraordinary life"?

Bioinformatics approaches for studying untranslated regions of mRNAs / Paramjeet S. Bagga -- Identification of mRNA polyadenylation sites in genomes using cDNA sequences, expressed sequence tags, and trace / Ju Youn Lee, Ji Yeon Park, and Bin Tian -- Bioinformatic tools for studying post-transcriptional gene regulation : the UAlbany TUTR Collection and other informatic resources / Francis Doyle ... [et al.] -- In-line probing analysis of riboswitches / Elizabeth E. Regulski and Ronald R. Breaker -- Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs / Dale L. Beach and Jack D. Keene -- Advances in RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray profiling / Timothy E. Baroni ... [et al.] -- Biosensors for RNA aptamers-protein interaction / Sara Tombelli, Maria Minunni, and Marco Mascini -- A tethering approach to study proteins that activate mRNA turnover in human cells / Sandra L. Clement and Jens Lykke-Andersen -- RNA analysis by biosynthetic tagging using a 4-thiouracil and uracil phosphoribosyltransferase / Gusti M. Zeiner ... [et al.] -- Efficient 5' cap-dependent RNA purification : use in identifying and studying subsets of RNA / Edyta Z. Bajak and Curt H. Hagedorn -- Enrichment of alternatively spliced isoforms / Julian P. Venables --In vivo methods to assess polyadenylation efficiency / Lisa K. Hague, Tyra Hall-Pogar, and Carol S. Lutz -- Monitoring the temporal and spatial distribution of RNA in living yeast cells / Roy M. Long and Carl R. Urbinati -- Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells / Samuel B. Stephens ... [et al.] -- In vivo and in vitro analysis of poly(A) length effects on mRNA translation / Jing Peng, Elizabeth L. Murray, and Daniel R. Schoenberg -- A ribosomal density-mapping procedure to explore ribosome positions along translating mRNAs / Naama Eldad and Yoav Arava -- Identification of changes in gene expression by quantitation of mRNA levels / Wendy M. Olivas -- Application of the Invader® RNA assay to the polarity of vertebrate mRNA decay / Elizabeth L. Murray and Daniel R. Schoenberg -- Development of an in vitro mRNA decay system in insect cells / Kevin Sokoloski, John R. Anderson, and Jeffrey Wilusz -- Using synthetic precursor and inhibitor miRNAs to understand miRNA function / Lance P. Ford and Angie Cheng -- A step-by-step procedure to analyze the efficacy of siRNA using real-time PCR / Angie Cheng, Charles L. Johnson, and Lance P. Ford.

STAR trek: an introduction to STAR family proteins and review of quaking (QKI) / Karen Artzt and Jiang I. Wu -- The STAR family member: QKI and cell signaling / Yue Feng and Andrew Bankston -- Insights into the structural basis of RNA : recognition by STAR domain proteins / Sean P. Ryder and Francesca Massi -- Post-translational regulation of STAR proteins and effects on their biological functions / Claudio Sette -- Expression and fuctions of the STAR proteins Sam68 and T-STAR in mammalian spermatogenesis / Ingrid Ehrmann and David J. Elliott -- The role of quaking in mammalian embryonic development / Monica J. Justice and Karen K. Hirschi -- Drosophila STAR proteins: what can be learned from flies? / Talila Volk -- C. elegans STAR proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development / Min-Ho Lee and Tim Schedl -- The branchpoint binding protein: in and out of the spliceosome cycle / Brian C. Rymond -- Reaching for the STARs: linking RNA binding proteins to diseases / Stéphane Richard.

Disulfide bond mapping by cyanylation-induced cleavage and mass spectrometry / Jiang Wu -- Detection of post-translational modifications by fluorescent staining of two-dimensional gels / Archana M. Jacob and Chris W. Turck -- Identification of protein phosphorylation sites by advanced LC-ESI-MS/Ms methods / Christoph Weise and Christof Lenz -- Analysis of tyrosine-O-sulfation / Jens R. Bundegaard ... [et al.] -- [alpha]-amidated peptides : approaches for analysis / Gregory P. Mueller and William J. Driscoll -- [gamma]-glutamate and [beta]-hydroxyaspartate in proteins / Francis J. Castellino, Victoria A. Ploplis, and Li Zhang -- Lysine hydroxylation and cross-linking of collagen / Mitsuo Yamauchi and Masashi Shiiba -- Mass spectrometric determination of protein ubiquitination / Carol E. Parker ... [et al.] -- Analysis of sumoylation / Andrea Pichler -- Detection and analysis of protein ISGylation / Tomoharu Takeuchi and Hideyoshi Yokosawa -- Analysis of methylation, acetylation, and other modifications in bacterial ribosomal proteins / Randy J. Arnold, William Running, and James P. Reilly -- Analysis of S-acytlation of proteins / Michael Veit, Evgeni Ponimaskin, and Michael F.G. Schmidt -- Metabolic labeling and structural analysis of glycosylphosphatidylinositols from parasitic protozoa / Nahid Azzouz, Peter Gerol, and Ralph T. Schwarz -- 2-dimensional electrophoresis : detection of glycosylation and influence on spot pattern / Klemens Löster and Christoph Kannicht -- Carbohydrate composition analysis of glycoproteins by HPLC using highly fluorescent anthanilic acid (AA) tag / George N. Saddic, Shirish T. Dhume, and Kalyan R. Anumula -- Enzymatical hydrolysis of N-glycans from glycoproteins and fluorescent labeling by 2-aminobenzamide (2-AB) / Rolf Nuck -- Separation of N-glycans by HPLC / Martin Gohlke and Véronique Blanchard -- Enzymatic sequence analysis of N-glycans by exoglycosidase cleavage and mass spectrometry--detection of Lewis X structures / Christoph Kannicht, Detlef Grunow, and Lothar Lucka -- Immunochemical methods for the rapid screening of the O-glycosidically linked N-acetylglucosamine modification of proteins / Michael Ahrend ... [et al.] -- Analysis of O-glycosylation / Juan J. Calvete and Libia Sanz -- Characterization of site-specific N-glycosylation / Katalin F. Medzihradszky -- Monitoring glycosylation of therapeutic glycoproteins for consistency by HPLC using highly fluorescent anthranilic acid (AA) tag / Shirish T. Dhume, George N. Saddic, and Kalyan R. Anumula -- Comparability and monitoring immunogenic N-linked oligosaccharides from recombinant monoclonal antibodies from two different cell lines using HPLC with fluorescence detection and mass spectrometry / Bruce R.. Kilgore ... [et al.] -- Mass spectrometry and HPLC with fluorescent detection-based orthogonal approaches to characterize N-linked oligosaccharides of recombinant monoclonal antibodies / Adam W. Lucka ... [et al.] -- Web-based computational tools for the prediction and analysis of post-translational modifications of proteins / Vladimir A. Ivanisenko, Dmitry A. Afonnikov, and Nikolay A. Kolchanov.

Introduction / Vikas R. Dharnidharka, Michael Green and Steven Webber -- Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD) / Douglas W. Hanto -- Epidemiology of PTLD / Vikas R. Dharnidharka -- The Biology of Epstein-Barr Virus and Posttransplant Lymphoproliferative Disease / Olivia M. Martinez -- Epstein-Barr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders / Jutta K. Preiksaitis -- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder / Upton D. Allen -- Pathology / Steven H. Swerdlow -- Prognostic Factors for PTLD / Tapan Maniar and Donald Tsai -- Treatment of PTLD / Steven A. Webber -- Prevention of Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation / Michael Green and Marian Michaels -- Organ Specific Issues of PTLD - Kidney / Sophie Caillard -- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients / Jaime Pineda and George V. Mazariegos -- Heart and Lung Transplantation / Silke Wiesmayr and Steven A. Webber -- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT) / Thomas G. Gross -- Research Priorities and Future Directions / Vikas R. Dharnidharka, Michael Green and Steven A. Webber.

Post-traumatic stress disorder: definition, prevalence, and risk factors / Terence M. Keane, Brian P. Marx, and Denise M. Sloan -- The amygdala and the neural pathways of fear / Jacek Dębiec and Joseph LeDoux -- Physiology of the amygdala: implications for PTSD / Donald G. Rainnie and Kerry J. Ressler -- Counteracting molecular pathways regulating the reduction of fear: implications for the treatment of anxiety diseases / Andre Fischer and Li-Huei Tsai -- Memory in PTSD: a neurocognitive approach / Mieke Verfaellie and Jennifer J. Vasterling -- Toward animal models of post-traumatic stress disorder / Hagit Cohen and Gal Richter-Levin -- PTSD: from neurons to networks / Rajnish P. Rao ... [et al.] -- Arousal neurons in the brain / Priyattam J. Shiromani and Carlos Blanco-Centurion -- Hyperarousal and post-traumatic stress disorder: a role for the hypocretin system / Matt Carter and Luis de Lecea -- The locus coeruleus-noradrenergic system and stress: implications for post-traumatic stress disorder / Craig W. Berridge -- Effect of stress on sleep and its relationship to post-traumatic stress disorder / L.D. Sanford and X. Tang -- Stress hormones and PTSD / Rachel Yehuda -- Low basal cortisol and startle responding as possible biomarkers of PTSD: the influence of internalizing and externalizing comorbidity / Mark W. Miller, Erika J. Wolf, Laura Fabricant, and Nathan Stein -- Functional neuroimaging in post-traumatic stress disorder / Israel Liberzon and Sarah N. Garfinkel -- The amygdala in post-traumatic stress disorder / Lisa M. Shin -- Pharmacologic treatment of PTSD / Murray A. Raskind -- Guided imagery as a therapeutic tool in post-traumatic stress disorder / Jennifer L. Strauss, Patrick S. Calhoun, and Christine E. Marx -- Virtual reality exposure therapy for combat-related PTSD / Albert Rizzo ... [et al.].

Introduction to postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Specimen selection, collection, preservation, and security / Bradford R. Hepler and Daniel S. Isenschmid -- Common methods in postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Strategies for postmortem toxicology investigation / edited and revised by Henrik Druid -- Quality assurance in postmortem toxicology / Wilmo Andollo -- Interpretation of postmortem drug levels / Graham R. Jones.

Diagnosing postpolio syndrome: inclusion and exclusion criteria -- Evaluating and treating symptomatic postpolio patients -- The interdisciplinary team assessment -- Electrophysiology of postpolio syndrome -- Joint and muscle pain -- Postpolio fatigue -- Postpolio pulmonary dysfunction -- Speech and swallowing in postpolio syndrome -- Exercise in the treatment of postpolio syndrome -- Physical therapy in the management of chronic poliomyelitis and postpolio syndrome -- Aquatic therapy for polio survivors -- Screening and treatment of the polio foot and ankle -- Gait, orthoses, footwear, and assistive devices -- Powered mobility for polio survivors -- The role of occupational therapy in the management of polio survivors -- Energy conservation and pacing -- Aging with polio -- Psychological well-being of polio survivors.

Identifying transcriptional regulatory regions using reporter genes and DNA-protein interactions by chromatin immunoprecipitation / Lezanne Ooi and Ian C. Wood -- Quantitative RT-PCR methods for investigation of low copy potassium channel gene expresssion in native murine arteries / Alex Cheong, Samuel J. Fountain, and David J. Beech -- Cloning of potassium chanel splice variants from tissues and cells / Lie Chen and Michael J. Shipston -- Chemiluminescence assays to investigate membrane expression and clathrin-mediated endocytosis of KATP channels / Andrew J. Smith and Asipu Sivaprasadarao -- Investigation of KATP channel endocytosis by immunofluorescence / Andrew J. Smith and Asipu Sivaprasadarao -- Investigation of KATP channel endocytosis and cell surface density by biotinylation and western blotting / Andrew J. Smith and Asipu Sivaprasadarao -- Lipid microdomains and K+ channel compartmentation : detergent and non-detergent-based methods for the isolation and characterisation of cholesterol-enriched lipid rafts / Laura J. Sampson and Caroline Dart -- Determination of phosphoinositide binding to K+ channel subunits using a protein-lipid overlay assay / Alison M. Thomas and Andrew Tinker -- Protein complex analysis of native brain potassium channels by proteomics / Guillaume Sandoz and Florian Lesage -- Xenopus oocytes as a heterologous expression system for studying ion channels with the patch-clamp technique / Paolo Tammaro, Kenju Shimomura, and Peter Proks -- Whole-cell recording using the perforated patch clamp technique / Jonathan D. Lippiat -- Recording the activity of ATP-sensitive K+ channels in open-cell cell-attached configuration / Andrei I. Tarasov -- Planar patch clamp : advances in electrophysiology / Andrea Brüggemann ... [et al.] -- Analysing steroid modulation of BKCa channels reconstituted into planar lipid bilayers / Heidi de Wet, Jonathan D. Lippiat, and Marcus Allen -- Using bioluminescence resonance energy transfer to measure ion channel assembly / Gina M. Whitaker and Eric A. Accili -- The use of FRET microscopy to elucidate steady state channel conformational rearrangements and G protein interaction with the GIRK channels / Adi Raveh, Inbal Riven, and Eitan Reuveny -- The voltage-clamp fluorometry technique / Chris S. Gandhi and Riccardo Olcese -- Identification of mutations in the Kir6.2 subunit of the KATP channel / Sarah E. Flanagan and Sian Ellard -- Modulation of potassium ion channel proteins utilising antibodies / Mark L. Dallas, Susan A. Deuchars, and Jim Deuchars -- Fluorescence-based Tl+-influx assays as a novel approach for characterization of small-conductance CA²⁺-activated K+ channel modulators / Susanne Jørgensen, Tina H. Johansen, and Tino Dyhring -- Rubidium efflux as a tool for the pharmacological characterisation of compounds with BK channel opening properties / Neil G. McKay, Robert W. Kirby, and Kim Lawson -- Recording hERG potassium currents and assessing the effects of compounds using the whole-cell patch-clamp technique / Ray M. Helliwell.

The conceptual underpinnings of statistical power -- Strategies for increasing statistical power -- General guidelines for conducting a power analysis -- The t-test for independent samples -- The paired t-test -- One-way between subjects analysis of variance -- One-way between subjects analysis of covariance -- One-way repeated measures analysis of variance -- Interaction effects for factorial analysis of variance -- Power analysis for more complex designs -- Other power analytic issues and resources for addressing them.

Anesthetic management of cardiac transplantation / Zachariah Thomas, Anne L. Rother, and Charles D. Collard -- Arrhythmia, rhythm management devices, and catheter and surgical ablation / Jerry C. Luck -- Coagulation management during and after cardiopulmonary bypass / Linda Shore-Lesserson, Jay C. Horrow, and Glenn P. Gravlee -- Surgical ventricular restoration and remodeling / Benjamin C. Sun and Glenn P. Gravlee -- Cardiopulmonary bypass circuits: design and use / Alfred H. Stammers ... [et al.] -- Pathophysiology of cardiopulmonary bypass / Eugene A. Hessel, II and Joseph N. Ghansah -- Devices for cardiac support and replacement / Benjamin C. Sun, Ronald Harter, and Glenn P. Gravlee -- Intraoperative myocardial protection / John W. C. Entwistle, III and Andrew S. Wechsler -- Protection of the brain during cardiac surgery / John M. Murkin and Ivan Iglesias -- Anesthetic management for thoracic aortic aneurysms and dissections / Amanda A. Fox and John R. Cooper, Jr. -- Anesthetic management for surgery of the lungs and mediastinum / Peter Slinger and Erin A. Sullivan -- Pain management for cardiothoracic procedures / Mark Stafford-Smith and Thomas M. McLoughlin, Jr.The cardiac surgical patient / Donald E. Martin and Charles E. Chambers -- Cardiovascular drugs / Jeffrey R. Balser, John F. Butterworth, and David R. Larach -- Monitoring the cardiac surgical patient / Mark A. Gerhardt and Thomas M. Skeehan -- Transesophageal echocardiography / Jack S. Shanewise -- Induction of anesthesia / Michael B. Howie and Glenn P. Gravlee -- Anesthetic management in the precardiopulmonary bypass period / Anand R. Mehta, Mark E. Romanoff, and Michael G. Licina -- Anesthestic management during cardiopulmonary bypass / Neville M. Gibbs and David R. Larach -- The postcardiopulmonary bypass period: weaning to ICU transport / Mark E. Romanoff and Roger L. Royster -- Postoperative care of the cardiac surgical patient / Mark A. Gerhardt -- Anesthetic management of myocardial revascularization / Gary Okum and Jay C. Harrow -- Anesthetic management for the surgical treatment of valvular heart disease / Mikhail R. Sukernik and Donald E. Martin -- Alternative approaches to cardiac surgery with and without cardiopulmonary bypass / James Ramsay, Michael G. Licina, and Anand R. Mehta -- Anesthetic management for patients with congenital heart disease / Laurie K. Davies and Daniel G. Knauf --

Section I. Preventive Cardiology -- Chapter 1. Prevention of Cardiovascular Disease / Maulik Shah and Reza Ardehali -- Chapter 2. Dyslipidemia / Karim Sallam and Reza Ardehali -- Chapter 3. Hypertension / Christopher Woods and Richard Lafayette -- Section II. Coronary Artery Disease -- Chapter 4. Stable Angina / Joshua Lehrer and William F. Fearon -- Chapter 5. Unstable Angina and Non-ST Elevation Myocardial Infarction / Joshua Lehrer and David P. Lee -- Chapter 6. ST-Elevation Myocardial Infarction / Yen Tibayan -- Section III. Heart Failure -- Chapter 7. Care of the Cardiomyopathic Patient / Nicholas J. Leeper, Reza Ardehali and Michael Fowler -- Chapter 8. Pulmonary Hypertension and Right Heart Failure / Matthew T. Wheeler and Roham T. Zamanian -- Chapter 9. Heart Transplantation / Jesus Almendral, Robert Maranda and Sharon Hunt -- Section IV. Valvular and Vascular Disease -- Chapter 10. Valvular Heart Disease / Reza Ardehali and Ingela Schnittger -- Chapter 11. Diseases of the Aorta / Michael Ho and David Liang -- Chapter 12. Peripheral Vascular Disease / Andrew Wilson, Reza Ardehali and John Cooke -- Section V. Arrhythmias and Sudden Cardiac Death -- Chapter 13. Atrial Fibrillation and Flutter / Marco Perez and Amin Al-Ahmad -- Chapter 14. Supraventricular Tachycardia / Marco Perez and Paul Zei -- Chapter 15. Ventricular Tachycardia / Jeffrey Hsing and Henry Hsia -- Chapter 16. Bradycardia / Jeffrey Hsing and Paul Wang ---- Chapter 17. Syncope / Farheen Shirazi and Karen Friday -- Section VI. Cardiovascular Disease in Special Populations -- Chapter 18. Congenital Heart Disease / Patrick Yue -- Chapter 19. Cardiology Consultation and Management of Perioperative Complications / Azar Mehdizadeh and Stanley G. Rockson -- Chapter 20. Management of Pre- and Post-Cardiac Surgery Patients / Mohammad Haghdoost and Ramin Beygui -- Section VII. Specialized Testing and Therapeutics -- Chapter 21. Adult Advanced Cardiac Life Support / Anurag Gupta and Amin Al-Ahmad -- Chapter 22. ECG Interpretation / Marco Perez and Victor F. Froelicher -- Chapter 23. Transthoracic and Transesophageal Echocardiography / Shahriar Heidary and Ingela Schnittger -- Chapter 24. Noninvasive Stress Testing / Arvindh Kanagasundram and Victor F. Froelicher -- Chapter 25. Cardiac MRI and CT / Chandra Katikireddy and Michael V. McConnell -- Chapter 26. Clinical Cardiac Hemodynamics / Shirley Park and Euan Ashley -- Chapter 27. Percutaneous Interventions / Aiden O'Loughlin and Alan Yeung -- Chapter 28. Pacemakers and ICD Troubleshooting / Marco Perez and Paul Wang -- Chapter 29. Introduction to Electrophysiology Studies / Ronald Lo and Henry Hsia.

Local anesthetics / Christopher M. Bernards -- Local anesthetic clinical pharmacology / Christopher M. Bernards -- Complications of regional anesthesia / Christopher M. Bernards -- Premedication and monitoring / Michael F. Mulroy -- Equipment / Michael F. Mulroy -- Spinal anesthesia / Francis V. Salinas -- Epidural anesthesia / Christopher M. Bernards -- Caudal anesthesia / Michael F. Mulroy -- Intercostal and terminal nerve anesthesia of the trunk / Michael F. Mulroy -- Paravertebral block / Christopher M. Bernards -- Sympathetic blockade / Christopher M. Bernards -- Brachial plexus blocks / Susan B. McDonald -- Intravenous regional anesthesia / Susan B. McDonald -- Peripheral nerve blocks of the upper extremity / Susan B. McDonald -- Lumbar plexus blocks / Francis V. Salinas -- Sacral plexus-sciatic nerve blocks / Francis V. Salinas -- Airway / Michael F. Mulroy -- Head and face / Christopher M. Bernards -- Cervical plexus blocks / Michael F. Mulroy -- Ophthalmic anesthesia / Susan B. McDonald -- Pediatric regional anesthesia / Kathleen L. Larkin -- Ambulatory surgery / Michael F. Mulroy -- Postoperative pain management / Susan B. McDonald.

Chapter 1. Bacterial Communities by Location and Function -- Chapter 2. Common Bacteriologically Initiated Events -- Chapter 3. Bacteria Are Everywhere -- Chapter 4. Preliminary Differentiation of Alpha Bacterial Consorms -- Chapter 5. Environmental Dynamics of Bacterial Consorms -- Chapter 6. Bacterial Consormial Challenges -- Chapter 7. Detailed Identification of Bacterial Consorms -- Chapter 8. Biochemical Methods for Identification of Consorms -- Chapter 9. Identifying Bacterial Consorms Using BART -- Chapter 10. Introduction to Grid-Formatted Bacteriological Atlas -- Chapter 11. Defining Bacterial Consorms in Gridded Atlas Format -- Chapter 12. Natural Bacteriological Consorms.

Computational methods for protein structure prediction / I.A. Cymerman ... [et al.] -- "Meta" approaches to protein structure prediction / J.M. Bujnicki, D. Fischer -- From molecular modeling to drug design / M. Cohen-Gonsaud ... [et al.] -- Structure determination of macromolecular complexes by experiment and computation / F. Alber, N. Eswar, A. Sali -- Modeling protein folding pathways / C. Bystroff, Y. Shao -- Structural bioinformatics and NMR structure determination / J.P. Linge, M. Nilges -- Bioinformatics-guided identification and experimental characterization of novel RNA methytransferases / J.M. Bujnicki ... [et al.] -- Finding missing tRNA modification genes: a comparative genomics goldmine / V. de Crécy-Lagard -- Evolution and function of processosome, the complex that assembles ribosomes in eukaryotes: clues from comparative sequence analysis / A. Mushegian -- Bioinformatics-guided experimental characterization of mismatch-repair enzymes and their relatives / P. Friedhoff -- Predicting functional residues in DNA glycosylases by analysis of structure and conservation / D.O. Zharkov.

What is data mining and what can it do? -- The data mining process -- Problem definition (Step 1) -- Data evaluation (Step 2) -- Feature extraction and enhancement (Step 3) -- Prototyping plan and model development (Step 4) -- Model evaluation (Step 5) -- Implementation (Step 6) -- Supervised learning Genre section 1 - Detecting and characterizing known patterns -- Forensic analysis Genre Section 2 -Detecting, characterizing, and exploiting hidden patterns -- Genre Section 3 - Knowledge : Its acquisition, representation, and use.

Motivation for design control and validation -- Design control requirements -- Design transfer and process validation -- Quality system for design control -- Measuring design control program effectiveness -- Medical device reliability overview -- Reliability plan -- Risk analysis and FMEA -- Designing-in reliability -- Reliability and design verification -- Reliability and design validation.

Evidence-based physiotherapy : what, why and how? -- What do I need to know? -- What constitutes evidence? -- Finding the evidence -- Can I trust this evidence? -- What does this evidence mean for my practice? -- Clinical guidelines as a resource for evidence-based physiotherapy -- When and how should new therapies be introduced into clinical practice? -- Making it happen -- Am I on the right track?

The endoscopy unit and staff -- Staff -- Facilities -- Management and behaviour -- Documentation -- Educational resources -- Equipment -- A brief history -- Endoscopes -- Endoscopic accessories -- Ancillary equipment -- Energy sources -- Equipment maintenance -- Infection control -- Cleaning and disinfection -- Patient care -- Indications for upper endoscopy -- Patient preparation -- Risks, unplanned events (complications) -- Predicting and reducing risks -- Monitoring -- Medications and sedation practice -- Recovery and discharge -- Risk management -- Diagnostic upper endoscopy techniques -- Endoscope handling -- Passing the endoscope -- Routine diagnostic survey -- Problems during endoscopy -- Recognition of lesions -- Specimen collection -- Endoscopy in special circumstances -- Therapeutic upper endoscopy -- Benign esophageal strictures -- Achalasia -- Esophageal cancer palliation -- Gastric and duodenal stenosis -- Gastric and duodenal polyps and tumors -- Foreign bodies -- Acute bleeding -- Enteral nutrition -- Colonoscopy and flexible sigmoidoscopy.

The endoscopy unit and staff -- Endoscopic equipment -- Patient care, risks, and safety -- Upper endoscopy : diagnostic techniques -- Therapeutic upper endoscopy -- Colonoscopy and flexible sigmoidoscopy -- Therapeutic colonoscopy -- Resources and links.

Indications for pacing -- Pacemaker technology -- Principles of pacemaker-myocardial interaction -- Programmability and specialized circuits -- Types of pacemakers and hemodynamics of pacing -- Dual-chamber pacing : special considerations -- Cardiac resynchronization therapy -- Rate-modulated pacing -- Implantable cardioverter defibrillator and antitachycardia pacing -- Pacemaker implantation -- Follow-up of the patient who has received a pacemaker.

Understanding and Maintaining the Cryostat / Philip Hyam -- Gross Examination of Tissues in the Frozen Section Room / Stephen R. Peters -- Embedding of Tissue for Frozen Section / Stephen R. Peters -- Cutting the Frozen Section / Stephen R. Peters -- Variables Affecting the Cutting Properties of Tissues and the Resulting Artifacts / Stephen R. Peters -- Fixation, Staining and Coverslipping of Frozen Section Slides / Stephen R. Peters and Catherine Susan Delia -- Microscopic Interpretation in the Frozen Section Setting / Stephen R. Peters -- Frozen Section Techniques Used in Mohs Micrographic Surgery / Barbara Beck and Stephen R. Peters -- Frozen Section Technique in the Animal Research Setting / Charles W. Scouten.

Introduction to near-infrared spectra -- Alkanes and cycloalkanes -- Alkenes and alkynes -- Aromatic compounds -- Hydroxyl containing compounds -- Water -- Carbonyls -- Amines and amides -- P-H and S-H -- Carbohydrates -- Amino acids, peptides, and proteins -- Synthetic polymers and rubbers -- History of near-infrared (NIR) applications.

Section 1. The palliative care approach -- Section 2. Cultural diversity in end-of-life care -- Section 3. Approach to the patient -- Section 4. Predicting life expectancy -- Section 5. Delivery of palliative care -- Section 6. Terminal care -- Section 7. Nonpain symptom management -- Section 8. Pain control -- Section 9. Palliative interventions -- Section 10. The palliative pediatric patient -- Section 11. Charting -- Section 12. Ethics at the end of life.

"This practical guide is written for the emergency department physician who cares for adults and children concurrently and provides all the information needed to diagnose and treat a wide variety of common and uncommon pediatric disorders. Each chapter takes a clinical perspective, emphasizing differences in adult and pediatric disease process and management. Key facts, special considerations, and pearls and pitfalls are highlighted, providing rapid access to vital knowledge in emergency situations. Sections are dedicated to specific pediatric populations, including neonates, adolescents, and children with special health care needs. High-quality photographs, illustrations and diagrams enhance the text throughout and tutorials cover pediatric imaging, pediatric EKG interpretation, procedural sedation, and procedures. Written by pediatric and emergency medicine specialists and subspecialty experts, this is a must-have text for emergency medicine physicians and trainees, as well as family practice health care practitioners"--Provided by publisher.

Role of psychiatric factors in medical practice / Roger Lowell McRoberts III -- Psychiatric interview and database / Richard J. Goldberg -- Medical evaluation of psychiatric symptoms / Richard J. Goldberg -- Delirium, dementia, and other cognitive disorders / Sandra A. Jacobson -- Alzheimer's disease: diagnosis and treatment / Richard J. Goldberg -- Depression: identification and diagnosis / Michael A. Posternak and Mark Zimmerman -- Antidepressants / Michael A. Posternak and Mark Zimmerman -- Bipolar disorder and mood-stabilizing drugs / Christine J. Truman -- Anxiety disorders: diagnosis and management / Richard J. Goldberg and Donn Posner -- Treatment of anxiety: medications and therapies / Richard J. Goldberg, Donn Posner, and Mark Zimmerman -- Sleep problems and the use of hypnotics / Richard P. Millman -- Psychotic symptoms, schizophrenia, and antipsychotic agents / Moataz M. Ragheb -- Somatoform disorders / Colin J. Harrington -- Behavioral emergencies forensic issues / Ali Kazim -- Alcohol and substance abuse / Michael D. Stein -- Electroconvulsive therapy / David A. Solomon -- Personality disorders / Daniela A. Boerescu -- Eating disorders, obesity, and nicotine dependence / Mark B. Elliot -- Sexual disorders / John P. Wincze -- The P450 system: drug interactions / Richard J. Goldberg -- Child and adolescent psychiatry / Joseph V. Penn -- Formulary.

The language of the pedigree -- Practical inheritance -- Getting to the roots : recording the family tree -- Directed medical-genetic family history questions : separating the trees from the forest -- Using a pedigree to recognize individuals with an increased susceptibility to cancer -- Medical verification of family history, and resources for patients to record their genetic family histories -- The challenge of family history and adoption -- Family history and assisted reproductive technologies -- Genetic counseling : where to turn, what to expect, and the pedigree as a psychosocial assessment and counseling tool -- Pedigree predicaments.

The gynecologic examination / Pamela Charney -- Sexuality / Sharon J. Parish and William H. Salazar -- Menstrual disorders and abnormal bleeding / Shawn Kurtcheff and Mark Gibson -- Premenstrual syndrome / Janice Ryden -- Contraception / Alison B. Edelman -- Spontaneous and induced abortion / Laura D. Castleman and Paul D. Blumenthal -- Cervical cancer prevention / Auguste H. Fortin VI -- Vaginitis and sexually transmitted diseases / Roxanne Jamshidi and Jonathan Zenilman -- Gynecologic emergencies / Kindra Larson, Dee Fenner, and Janice Ryden -- Urinary incontinence / Lisa Granville and Dee Fenner -- Endometriosis / John C. Petrozza -- Chronic pelvic pain / Candace N. Howe and Andrea J. Rapkin -- Evaluation of pelvic masses / Anita L. Nelson, Robert M Sinow, and Monica Hau Hien Le -- Hysterectomy and alternatives / Mary T. Jacobson -- Menopause / Anne W. Moulton, Mary H. Hohenhaus, and Michelle Stozek Anvar -- Menopausal hormone therapy : benefits, risks and regimens / Rebekah Wang-Cheng and Ann Butler Nattinger -- Diseases of the vulva / Paula Zook -- Breast cancer screening and management of common breast problems / Leah Wolfe -- Preconception care / Joyce A. Sackey and Gerda Ellen Tapelband -- Infertility / Bert Scoccia and Janice Ryden -- Intimate partner violence / Joslyn W. Fisher, Amy Weil, and Christina Nicolaidis -- Lesbian health issues / Audrey S. Koh and Anne Rosenthal.

Part I.Instrumentation /Instrumentation /Kazuya Akahoshi --Part II.Ultrasound Catheter Probe /Ultrasound Catheter Probe (UCP) /Kazuya Akahoshi and Masaru Kubokawa --Part III.Radial Endoscopic Ultrasonography (EUS) /Basic Scanning Methods of Radial EUS /Kazuya Akahoshi --Radial EUS of the Esophagus and Mediastinum /Kazuya Akahoshi --Radial EUS of the Stomach /Kazuya Akahoshi --Radial EUS of the Anus and Rectum /Kazuya Akahoshi --Radial EUS of Pancreatico-Biliary System /Kazuya Akahoshi --Part IV.Linear EUS /Basic Scanning Techniques of Linear EUS /Amol Bapaye and Advay Aher --Linear EUS of the Esophagus and Mediastinum /Amol Bapaye and Advay Aher --Linear EUS of the Stomach /Amol Bapaye and Advay Aher --Linear EUS of the Anorectum /Amol Bapaye and Advay Aher --Linear EUS of the Pancreas, Biliary Tract and Liver /Amol Bapaye and Advay Aher --Part V.Endoscopic Ultrasonography-Guided Fine Needle Aspiration (EUS-FNA) /Techniques of EUS-FNA /Amol Bapaye and Advay Aher --Cytopathological Aspects of EUS-FNA /Vijayshri Pethe-Bhide and Amol Bapaye --EUS-FNA of the Esophagus and Mediastinum /Amol Bapaye and Advay Aher --EUS-FNA of Lesions of the Pancreas, Biliary Tract, and Liver /Amol Bapaye and Advay Aher --EUS-FNA for Submucosal Tumor /Kazuya Akahoshi and Masafumi Oya --Part VI.Interventional EUS /EUS Guided Drainage of Pancreatic Pseudocysts (PPC's), Abscesses and Fluid Collections (PFC's) /Amol Bapaye and Advay Aher --EUS Guided Biliary and Pancreatic Duct Interventions /Amol Bapaye and Advay Aher --EUS Guided Celiac Plexus Interventions /Rajkumar Wadhwa and Amol Bapaye --EUS Guided Anorectal Interventions.

v. 1. Cranial approaches, vascular, traumas, cerebrospinal fluid, infections -- v. 2. Intracranial tumors, intraoperative explorations, pediatrics -- v. 3. Spine, functional, peripheral nerves, education.

A. Introduction -- B. Passive or active pharmacovigilance? -- C. Spontaneous reporting -- D. Cohort event monitoring -- E. Data processing -- F. Special types of event -- G. Relationship/causality assessment -- H. Signal identification -- I. Strengthening the signal -- J. Identifying risk factors -- K. Analyses -- L. Differences between spontaneous reporting and cohort event monitoring -- M. Organization -- N. Communication -- Annex.

An overview of the management of thyroid cancer -- The UK evidence-based guidelines for the management of thyroid cancer: key recommendations -- Thyroid cancer multidisciplinary team and the organisational paradigm -- Thyroid cancer form the perspective of a patient -- The role of the specialist nurse -- The role of the clinical psychologist -- Thyroid nodules -- Thyroid cancer and the general practitioner -- The role of pathologist -- Thyroid cancer and the endocrinologist -- The specialist endocrine surgeon -- Initial thyroid surery for patient with differentiated thyroid carcinoma -- Management of cervical lymph nodes in differentiated thyroid cancer -- Complications of thyroid surgery -- Non-surgical management of thyroid cancer -- Fertility following treatment with iodine-131 for thyroid cancer -- Recombinant human TSH (rhTSH): use in papillary and follicular thyroid cancer -- Thyroglobulin -- Follow-up of patients with differentiated thyroid carcinoma --- Management of differentiated thyroid carcinoma patients with negative whole-body radioiodine scans and elevated serum thyroglobulin levels -- Medullary thyroid cancer: diagnosis and management -- Nonmedullary thyroid cancer and the role of the geneticist -- Thyroid cancer in childhood -- Radiation-induced thyroid cancer: lessons from Chernobyl -- The use of stable potassium iodide (KI) in the event of a nuclear emergency -- Ultrasound of the thyroid -- Diagnostic nuclear medicine investigations in the management of thyroid cancer -- CT and MRI in thyroid cancer -- Papillary microcarcinoma of the thyroid -- Rare thyroid cancers -- Management of anaplastic thyroid cancer -- Specialist palliative care for anaplastic thyroid carcinoma -- Emerging therapies for thyroid cancer -- Clinical trials for thyroid carcinoma: past, present, and future.

The normal foot -- The high-risk foot -- The ulcerated foot -- The infected foot -- The necrotic foot -- The unsalvageable foot.

Part 1.Setting Up and Running an IVF Laboratory /Building the Laboratory /Dean E. Morbeck and Marlena Duke --Air Quality Management /Johan Guns, Ronny Janssens and Martine Vercammen --Organizational Aspects of the Laboratory in a Tertiary Care ART Center /Nancy L. Bossert and Christopher De Jonge --Quality Control Management /William R. Boone and H. Lee Higdon --Daily, Weekly, and Regular Preparations for the IVF Laboratory /Michael A. Britt and Klaus E. Wiemer --Risk and Safety in the IVF Clinic /Peter Sjoblom and Julius Hreinsson --Journey of Human Gametes In Vitro: 1978-2010 /Zeev Shoham.Part 2.IVF Laboratory Equipment and Culture Systems --Essential Instruments and Disposable Supplies for an IVF Laboratory /Leslie Weikert, Christa Fralick and Klaus E. Wiemer --Co2 and Low-O2 Incubators /Marius Meintjes --IVF Workstations /Nicolas Prados and Alex C. Varghese --Culture Media in IVF: Decisions for the Laboratory /Jason E. Swain and Thomas B. Pool.Part 3.In Vitro Fertilization --Oocyte Denuding /Roberta Maggiulli, Filippo Ubaldi and Laura Rienzi --Assessment of Oocyte Quality /Basak Balaban, Turgay Barut and Bulent Urman --Polarization Microscopy /Markus Montag, Maria Köster and Hans van der Ven --Cumulus Cell Gene Expression in Assessment of Oocyte Quality /Dagan Wells.Part 4.Embryo Culture Methods --Short Culture: Day 1/Day 2/Day 3 Embryo Culture /Patrick Quinn --Extended Culture in IVF /David K. Gardner and Michelle Lane --In Vitro Maturation of Human Oocytes /Baris Ata, Jack Huang and Ri-Cheng Chian --In Vivo Embryo Culture Device /Claude Ranoux --Microfluidics for Gamete Manipulation and Embryo Culture /Gary D. Smith, Charles Bormann and Shuichi Takayama.Part 5.Sperm Processing and Selection --Sperm Assessment: Traditional Approaches and Their Indicative Value /Margot Flint, Fanuel Lampiao, Ashok Agarwal and Stefan S. du Plessis --Sperm Assessment: Novel Approaches and Their Indicative Value /De Yi Liu, Harold Bourne, Claire Garrett, Gary N. Clarke and Shlomi Barak, et al. --Sperm Processing for IVF /Ralf Henkel --PESA/TESA/TESE Sperm Processing /Sandro C. Esteves and Sidney Verza --Processing Sperm Samples in HIV-Positive Patients /Thamara Viloria, Marcos Meseguer, Antonio Pellicer, José Remohí and Nicolás Garrido --Intracytoplasmic Morphologically Selected Sperm Injection /P. Vanderzwalmen, Magnus Bach, Batsuren Baramsai, A. Neyer and Delf Schwerda, et al. --Sperm Testing and ICSI Selection by Hyaluronic Acid Binding: The Hyaluronic Acid-Coated Glass Slide and Petri Dish in the Andrology and IVF Laboratories /Gabor Huszar --Electrophoretic Sperm Separation /Steven Fleming and John Aitken --Magnetic-Activated Cell Sorting of Human Spermatozoa /Enver Kerem Dirican --Polscope-Based Sperm Selection /Luca Gianaroli, Cristina Magli, Andor Crippa, Giorgio Cavallini and Eleonora Borghi, et al..Part 6.Insemination Procedures --Intrauterine Insemination /Gautam N. Allahbadia and Rubina Merchant --Conventional IVF Insemination /Liesl Nel-Themaat, Thomas Elliott, Ching-Chien Chang, Graham Wright and Zsolt Peter Nagy --Intracytoplasmic Sperm Injection /Gianpiero D. Palermo, Queenie V. Neri, Devin Monahan, Takumi Takeuchi and Peter N. Schlegel, et al. --Mechanism of Human Oocyte Activation During ICSI and Methodology for Overcoming Low or Failed Fertilization /Dmitri Dozortsev and Mohammad Hossein Nasr-Esfahani.Part 7.Micromanipulators and Micromanipulation --Hydraulic Manipulators for ICSI /Hubert Joris --Research Instruments Micromanipulators /Steven Fleming and Catherine Pretty --Eppendorf Micromanipulator: Setup and Operation of Electronic Micromanipulators /Ehab Abu-Marar and Safa Al-Hasani --The Leica Microsystems' IMSI System /Christiane Wittemer, Bruno Laborde, Frederic Ribay and Stephane Viville --Automated Robotic Intracytoplasmic Sperm Injection /Zhe Lu, Xinyu Liu, Xuping Zhang, Clement Leung and Navid Esfandiari, et al. --Oocyte Treatment and Preparation for Microinjection /Thomas Ebner --Livestock Production via Micromanipulation /Akira Onishi and Anthony C. F. Perry.Part 8.Embryo Evaluation, Grading, and Assisted Hatching --Pronuclear Scoring in Human In Vitro Fertilization /Lynette Scott --Cumulative Morphological Assessment of Embryo Quality /Barry Behr and Aparna Hegde --Metabolomics: The ViaMetrics-E Procedure for Assessing Embryo Viability /D. Sakkas, L. Botros, M. Henson, K. Judge and P. Roos --Oxygen Consumption as an Indicator of Oocyte and Embryo Viability /Ana S. Lopes --Gene Expression Changes During Human Early Embryo Development: New Applications for Embryo Selection /Samir Hamamah, Said Assou, Imène Boumela and Hervé Dechaud --Amino Acid Turnover as a Biomarker of Embryo Viability /Christine Leary, Danielle G. Smith, Henry J. Leese and Roger G. Sturmey --Real-Time Embryo Monitoring Device for Embryo Selection /Gábor Vajta and Thorir Hardarson --Assisted Hatching in IVF /Itziar Belil and Anna Veiga.Part 9.Biopsy Procedures on Oocytes and Embryos --Polar Body Biopsy /Markus Montag, Maria Köster, K. van der Ven and Hans van der Ven --Cleavage-Stage Embryo Biopsy /Alan R. Thornhill --Embryo Biopsy for PGD: Current Perspective /Steven J. McArthur, Don Leigh, Maria Traversa, James Marshall and Robert P. S. Jansen --Microarrays and CGH for PGD of Chromosome Abnormalities and Gene Defects /Gary Harton and Santiago Munné.Part 10.Cryopreservation --Sperm Cryopreservation /Fabio Firmbach Pasqualotto, Eleonora Bedin Pasqualotto, Edson Borges and Ashok Agarwal --Slow Freezing of Oocytes /Giovanni Coticchio and Lucia De Santis --Vitrification: Research in Animal Models /Gábor Vajta --Oocyte Vitrification /Ana Cobo --Slow Freezing of Embryos /Liesl Nel-Themaat, Ching-Chien Chang, Thomas Elliott, Patricia Bernal and Graham Wright, et al. --Vitrification of Embryos /Juergen Liebermann, Joe Conaghan, Zsolt Peter Nagy and Michael Tucker --Directional Freezing of Reproductive Cells, Tissues, and Organs /Amir Arav --Ovarian Tissue Cryopreservation /Jennifer L. Kulp, J. Ryan Martin and Pasquale Patrizio.Part 11.Embryo Transfer --Assessment of Uterine Receptivity /Hakan Cakmak and Hugh S. Taylor --Single Embryo Transfer /Thorir Hardarson and Matts Wikland --Ultrasound-Guided Embryo Transfer (Abdominal/Vaginal): An Evidence-Based Evaluation /Ahmed M. Abou-Setta --Cumulus-Aided Embryo Transfer /Firuza R. Parikh, Nandkishor J. Naik, Dattatray J. Naik and Dhanajaya Kulkarni.Part 12.Management and Regulation in the ART Laboratory --Data Management in the ART Laboratory: Requirements and Solutions /Timothy Brown, Bruce R. Gilbert and Bruce R. Gilbert --Regulation, Licensing, and Accreditation of the ART Laboratory /Doris Baker --Legislation in the United Kingdom /Rachel Cutting --Regulation, Licensing, and Accreditation of the ART Laboratory in Europe /Julius Hreinsson and Peter Sjoblom --Regulation, Licensing, and Accreditation of ART Laboratories in India /B. N. Chakravarty and Rita Modi --Troubleshooting in the Clinical Embryology Laboratory: The Art of Problem-Solving in ART /Kathryn J. Go, Jay C. Patel and Rick Dietz.Part 13.Special Topics --The Role of Mitochondria in the Establishment of Developmental Competence in Early Human Development /Jonathan Van Blerkom --Nuclear and Cytoplasmic Transfer: Human Applications and Concerns /Josef Fulka and Helena Fulka --Cytoskeletal Architecture of Human Oocytes with Focus on Centrosomes and Their Significant Role in Fertilization /Heide Schatten, Vanesa Y. Rawe and Qing-Yuan Sun --Molecular Mining of Follicular Fluid for Reliable Biomarkers of Human Oocyte and Embryo Developmental Competence /Jonathan Van Blerkom.

ch. 1. Introduction, p. 1-7 -- ch. 2. Basic Sampling Techniques, p. 9-58 -- ch. 3. Further Use of Auxiliary Information, p. 59-110 -- ch. 4. Handling Nonsampling Errors, p. 111-129 -- ch. 5. Linearization and Sample Reuse in Variance Estimation, p. 131-186 -- ch. 6. Model-Assisted Estimation for Domains, p. 187-213 -- ch. 7. Analysis of One-Way and Two-Way Tables, p. 215-255 -- ch. 8. Multivariate Survey Analysis, p. 257-298 -- ch. 9. More Detailed Case Studies, p. 299-329.

Periarticular ligamentous tissue: a biochemical and physiologic assessment /David Amiel, Sakae Sano --Meniscus /Julie A. dodds, Steven P. Arnoczky --Articular cartilage: a brief review of its structure, function, and repair /Wayne H. Akeson, William Bugbee --Skeletal muscle and tendon /Thomas M. Best, John J. Wilson --Cervical spine injuries in the athlete /Rahul Banerjee, Michael P. Bradley, Mark A. Palumbo, Paul D. Fadale --The thoracolumbar spine /Donald Chow --Functional spinal rehabilitation /Lorraine Hendry --Scapulothoracic dysfunction, burners, stingers, thoracic outlet syndrome, and miscellaneous nerve injuries /Marc R. Safran, Anthony C. Luke --Head injures and concussion /Andrew d. Pearle, Ronnie Barnes, Russell F. Warren --Shoulder anatomy and biomechanics /Dawn L. Swarm, Andrew T. Mahar, Derek W. Weichel, Robert A. Pedowitz --Shoulder impingement /James Patrick Tasto, John K. Locke --Shoulder labral tears and instability /George F. Hatch III, John G. costouros, Peter J. MIllett, Jon J.P. Warner --The rotator cuff /Richard K.N. Ryu, Graham R. Hurvitz --Cartilage /Coarlos A. Guanche --Pectoralis major tendon ruptures /George K. Bal, Carl J. Bansamania --Acute injuries: shoulder fractures and acromioclavicular and sternoclavicular joint injuries /Robert Talac, Joel J. Smith --Adhesive capsulitis /Scott P. Fischer, Serge Kaska --Arthroscopic rotator cuff repair /James C. Esch, Jeffrey W. Taborlane --Thermal treatment, sutures, knots, and bone anchors /Robert A. Pedowitz --Throwing injuries /Walter A. Thomas, Heinz R. Hoenecke, Jan Fronek --Principles of shoulder rehabilitation /Benjamin D. Rubin --Elbow injuries /Ronald M. Selby, Marc R. Safran, Stephen J. O'Brien --Injuries of the wrist and hand /Ethan R. Wiesler, Jian Shen, Anastasios Papadonikolakis --Anatomy and kinematics of the hip /Mark R. Hutchinson, John Hung, J.W. Thomas Byrd --Hip arthroscopy /Michael H. Dienst --Intra-articular lesions /Aaron A. Bare, Carlos A. Guanche --Hip morphology and related pathology /J.W. Thomas Byrd --Extra-articular lesions /Aaron A. Bare, Carlos A. Guanche --Snapping hip syndrome /J.W. Thomas Byrd --Occult groin injuries: athletic pubalgia, sports hernia, and osteitis pubis /Michael B. Gerhardt, John A. Brown, Eric Giza --Sports related boney lesions of the hip: fractures, stress fractures, avulsion, AVN, dislocation, and subluxation /Carlos A.M. Higuera, Joshua M. Polster, Wael K. Barsoum, Viktor E. Krebs --Basic science of the knee /Donald H. Hohnson, Paul Johnson, Ali Alsuwaidi --The anterior cruciate ligament --Anterior cruciate reconstruction /Andrew Pickle, Aaron Campbell, Donald H. Johnson --Posterior mini-incision ACLR hamstring harvest /Chadwick Prodromos --Anatomic double bundle anterior cruciate ligament reconstruction /Steven B. Cohen, James Starman, Freddie H. Fu --Ligament injury and pain management /R. Lance Synder, Eric C. McCarty --Medial collateral ligament /Donald H. Johnson --Posterior cruciate ligament and posterolateral reconstruction /Gregory C. Fanelli -Posterior curciate ligament reconstruction with the posterior inlay graft /Donald H. Johnson --The ACL PCL injured (dislocated) knee /Gregory C. Fanellis, Daniel R. Orcutt, Justin D. Harris, David Zijerdi, Craig J. Edson --The meniscus /Monika Voleshy, Donald H. Johnson --Meniscus allografts /Walter R. Shelton --Patellar problems in athletes /Jeffrey Halbrecht --Fractures - tibial plateau, distal femur, patella, avulsions of the intercondylar eminence, Osgood-Schlatter disease /James H. Lubowitz, Wylie S. Elson, Dan Guttmann --Tendon disorders /William D. Stanish, Horacio Yepes, Amro Al-Hibshi --Chondral injuries and osteoarthritis --Chondral injuries in the knee /F. Alan Barber --Osteochondritis dissecans on the knee /Dawn L. Swarm, Robert A. PedowitzCartilage transplantation /Alberto Gobbi, Ramces A. Francisco --High tibial osteotomy /Tim Spalding, Price A.M. Gallie --Unicompartmental knee replacement /Jack M. Bert --Anterior cruciate ligament reconstruction with patellar tendon autograft: principles of rehabilitation /K. Donald Shelbrourne, Cairon Pfennig, Scott E. Lawrance --Leg, ankle, and foot: history, physical, and investigations /Kevin J. Wing, Alastair Younger --Muscle strains and contusions /Michael P. Swords, Douglas P. Dietzel --Chronic compartment syndrome /Robert A. Pdeowitz, Derek W. Weichel --Instability of the ankle /Murray J. Penner --Treatment of osteochondral lesions of the talar dome /James W. Stone --Tendon disorders in the lower extremity /Mark A. Glazebrook --Stress fractures of the athletic leg, ankle, and foot /Donald R. Boahy, Jonathan P. Cornelius, John G. Anderson --Ligamentous lisfranc joint injuries: leg - ankle - foot: midfoot injuries, lisfranc /Michael S. Aronow --Hallux valgus in the athlete /Walter J. Pedowitz, David I. Pedowitz --Stress fractures in athletes /Kurt P. Spindler, Michael S. George, Christopher C. Kaeding, Annunziato Amendola --Female issues in sport: risk factors and prevention of ACL injuries /Ligament injuries in children and adolescents /Patrick S. Brannan, Henry G. Chambers --Environmental issues for the athlete /Mark D. Bracker, Margoire Delo, Elise T. Gordon, Judy R. Schauer --Team physician issues; preparticipation evaluation /Bernie Lalonde --Running on the field /Richard Hawkins --Traveling team physician /Chadwick Prodromos --Mass participation events /Helen D. Iams, James Williams --Team physician consensus statement --Sideline preparedness for the team physician --Team physician and conditioning of athletes for sports --Team physician and return to play issues --Female athlete issues for the team physician.

Primary Prevention of Genetic Disorders and Place of Preimplantation Diagnosis --Approaches to Preimplantation Diagnosis --Preimplation Diagnosis for Single-Gene Disorders --PGD for HLA Typing --Preimplantation Diagnosis for Chromosomal Disorders --Clinical Outcome of Preimplantation Genetic Diagnosis --Preimplantation Diagnosis and Establishment of Disease and Individual Specific Human Embryonic Stem Cell Lines --Social, Ethical, and Legal Aspects.

v. 1. Respiratory failure -- v. 2. Disease management.

Architecture of the basic physiologic recorder -- Analog and digital signals -- Signals in the frequency domain -- Filters -- Techniques for event and feature detection -- Alternative techniques for rate estimation -- Signal averaging for noise reduction -- Data compression -- Image processing -- Electrocardiography -- Intravascular and intracardiac pressure measurement -- Blood pressure and pulse oximetry -- Coronary angiography -- Echocardiography -- Nuclear cardiology: SPECT and PET -- Magnetic resonance imaging -- Computed tomography -- ECG telemetry and long term electrocardiography -- Intracardiac electrograms -- Advanced signal processing applications of the ECG: T-wave alternans, heart rate variability, and the signal averaged ECG -- Digital stethoscopes.

SQL and relational database management -- Designing databases -- Creating and filling a database -- Selecting data from the database -- Sorting data and other selection techniques -- Grouping data and reporting from it -- Joining tables for comprehensive data analysis -- Structuring queries with subqueries -- Creating and using views -- Security, transactions, performance, and integrity -- Solving business problems.

1.Introduction --1.1.Types of Data --1.2.Descriptive Statistics/Data Summaries --1.3.Graphical and Tabular Representation --1.4.Population and Sample --1.5.Estimation and Testing Hypothesis --1.6.Normal Distribution --1.7.Nonparametric Methods --1.8.Some Useful Concepts --2.Qualitative Data --2.1.One Sample --2.1.1.Binary Data --2.1.2.t Categorical Responses --2.2.Two Independent Samples --2.2.1.Two Proportions --2.2.2.Odds Ratio and Relative Risk --2.2.3.Logistic Regression with One Dichotomous Explanatory Variable --2.2.4.Cochran-Mantel-Haenszel Test for a 2 x 2 Table --2.2.5.t Categorical Responses --2.3.Paired Two Samples --2.3.1.Binary Responses --2.3.2.t Categorical Responses --2.4.k Independent Samples --2.4.1.k Proportions --2.4.2.Logistic Regression When the Explanatory Variable Is Not Dichotomous2.4.3.CMH Test --2.4.4.t Categorical Responses --2.5.Cochran's Test --2.6.Ordinal Data --2.6.1.Row Mean Score Test --2.6.2.Cochran-Armitage Test --2.6.3.Measures of Association --2.6.4.Ridit Analysis --2.6.5.Weighted Kappa --2.6.6.Ordinal Logistic Regression --2.6.6.1.Two Samples --2.6.6.2.k Samples --3.Continuous Normal Data --3.1.One Sample --3.2.Two Samples --3.2.1.Independent Samples --3.2.1.1.Means --3.2.1.2.Variances --3.2.2.Paired Samples --3.3.k Independent Samples --3.3.1.One-Way Analysis of Variance --3.3.1.1.Variance --3.3.2.Covariance Analysis --3.4.Multivariate Methods --3.4.1.Correlation, Partial, and Intraclass Correlation --3.4.2.Hotelling's T2 --3.4.2.1.One Sample --3.4.2.2.Two Samples --3.4.3.One-Way Multivariate Analysis of Variance --3.4.4.Profile Analysis --3.4.5.Discriminant Functions --3.4.6.Cluster Analysis --3.4.7.Principal Components3.4.8.Factor Analysis --3.4.9.Canonical Correlation --3.5.Multifactor ANOVA --3.5.1.Crossed Factors --3.5.2.Tukey 1 df for Nonadditivity --3.5.3.Nested Factors --3.6.Variance Components --3.7.Split Plot Designs --3.8.Latin Square Design --3.9.Two-Treatment Crossover Design --4.Nonparametric Methods --4.1.One Sample --4.1.1.Sign Test --4.1.2.Wilcoxon Signed-Rank Test --4.1.3.Kolmogorov Goodness of Fit --4.1.4.Cox and Stuart Test --4.2.Two Samples --4.2.1.Wilcoxon-Mann-Whitney Test --4.2.2.Mood's Median Test --4.2.3.Kolmogorov-Smirnov --4.2.4.Equality of Variances --4.3.k Samples --4.3.1.Kruskal-Wallis Test --4.3.2.Median Test --4.3.3.Jonckheere Test --4.4.Transformations --4.5.Friedman Test --4.6.Association Measures --4.6.1.Spearman Rank Correlation --4.6.2.Kendall's Tau --4.6.3.Kappa Statistic --4.7.Censored Data4.7.1.Kaplan-Meier Survival Distribution Function --4.7.2.Wilcoxon (Gehan) and Log-Rank Test --4.7.3.Life-Table (Acturial Method) --5.Regression --5.1.Simple Regression --5.2.Polynomial Regression --5.3.Multiple Regressions --5.3.1.Multicollinearity --5.3.2.Dummy Variables --5.3.3.Interaction --5.3.4.Variable Selection --5.4.Diagnostics --5.4.1.Outliers --5.4.2.Influential Observations --5.4.3.Durbin-Watson Statistic --5.5.Weighted Regression --5.6.Logistic Regression --5.6.1.Dichotomous Logistic Regression --5.6.2.Multinomial Logistic Model --5.6.3.Cumulative Logistic Model --5.7.Poisson Regression --5.8.Robust Regression --5.9.Nonlinear Regression --5.10.Piecewise Regression --5.11.Accelerated Failure Time (AFT) Model --5.12.Cox Regression --5.12.1.Proportional Hazards Model --5.12.2.Proportional Hazard Assumption --5.12.3.Stratified Cox Model5.12.4.Time-Varying Covariates --5.12.5.Competing Risks --5.13.Parallelism of Regression Equations --5.14.Variance-Stabilizing Transformations --5.15.Ridge Regression --5.16.Local Regression (LOESS) --5.17.Response Surface Methodology: Quadratic Model --5.18.Mixture Designs and Their Analysis --5.19.Analysis of Longitudinal Data: Mixed Models --6.Miscellaneous Topics --6.1.Missing Data --6.2.Diagnostic Errors and Human Behavior --6.2.1.Introduction --6.2.2.Independent Samples --6.2.2.1.Two Independent Samples --6.2.2.2.k Independent Samples --6.2.3.Two Dependent Samples --6.2.4.Finding the Threshold for a Screening Variable --6.2.5.Analyzing Response Data with Errors --6.2.6.Responders' Anonymity --6.3.Density Estimation --6.3.1.Parametric Density Estimation --6.3.2.Nonparametric Univariate Density Estimation --6.3.3.Bivariate Kernel Estimator --6.4.Robust Estimators6.5.Jackknife Estimators --6.6.Bootstrap Method --6.7.Propensity Scores --6.8.Interim Analysis and Stopping Rules --6.8.1.Stopping Rules --6.8.2.Conditional Power --6.9.Microarrays and Multiple Testing --6.9.1.Microarrays --6.9.2.Multiple Testing --6.10.Stability of Products --6.11.Group Testing --6.12.Correspondence Analysis --6.13.Classification Regression Trees --6.14.Multidimensional Scaling --6.15.Path Analysis --6.16.Choice-Based Conjoint Analysis --6.16.1.Availability Designs and Cross Effects --6.16.2.Pareto-Optimal Choice Sets --6.16.3.Mixture-Amount Designs --6.17.Meta-Analysis --6.17.1.Homogeneity of the Effect Sizes --6.17.2.Combining the p-Values.