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all 1773 "P" titles


  • p53 2011
    TP53 mutations in human cancers : selection versus mutagenesis / Magali Olivier, Audrey Petitjean, Claude Caron de Fromentel, and Pierre Hainaut -- Lessons on p53 from mouse models / Dadi Jiang and Laura D. Attardi -- TP63, TP73 : the guardian's elder brothers / Stephanie Courtois, Pierre Hainaut and Claude Caron de Fromentel -- The regulation of p53 protein function by phosphorylation / Nicola J. Maclaine and Theodore Hupp -- The p53-Mdm2 loop : a critical juncture of stress response / Yaara Levav-Cohen, Zehavit Goldberg, Osnat Alsheich Bartok, Valentina Zuckerman, Sue Haupt and Ygal Haupt -- Cooperation between MDM2 and MDMX in the regulation of p53 / Jeremy Blaydes -- Regulation and function of the original p53-inducible p21 gene / Jennifer A. Fraser -- p53 localization / Carl G. Maki -- Modes of p53 interactions with DNA in the chromatin context / Vladana Vukojevic, Tatiana Yakovleva, and Georgy Bakalkin -- p53's dilemma in transcription : analysis by microarrays / Karuppiah Kannan, Gideon Rechavi and David Givol -- Tumor viruses and p53 / Nobuo Horikoshi -- p53 and immunity / Vikram Narayan, Sarah E. Meek and Kathryn L. Ball.
  • P53 in the clinics 2013
    TP53: Coordinator of the Processes That Underlie the Hallmarks of Cancer / Pierre Hainaut -- The Inheritance of p53 / Lukasz F. Grochola, Jorge Zeron-Medina, Emmanouela Repapi, Alexander E. Finlayson and Ying Cai, et al. -- p53: Guardian of the Metabolome / Masha V. Poyurovsky and Carol Prives -- The p53 Family and Stem Cell Biology / Massimiliano Agostini, Alessandro Rufini, Edward T. W. Bampton, Francesca Bernassola and Gerry Melino, et al. -- Mutant p53-Driven Tumorigenesis / Tamara Terzian and Guillermina Lozano -- Humanised Mouse Models: Targeting the Murine p53 Locus with Human Sequences / Monica Hollstein and Yang Xu -- p53 Models for Mammary Carcinogenesis / Wolfgang Deppert and Genrich Tolstonog -- TP53 Somatic Mutations: Prognostic and Predictive Value in Human Cancers / Magali Olivier -- Assessing TP53 Status in Human Tumors: Lessons from Breast Cancer / Anita Langerød, Magali Olivier and Anne-Lise Børresen-Dale -- TP53 Germline Mutations: Genetics of Li-Fraumeni Syndrome / Doua Bakry and David Malkin -- Tp53 Gene Therapy for Cancer Treatment and Prevention / Robert E. Sobol, Yong-Song Guan, Long-Jiang Li, Wei-Wei Zhang and Zhaohui Peng, et al. -- Upstream Targets in the p53 Pathway / Anna R. McCarthy and Sonia Lain -- p53-Reactivating Molecules as Research Tools and Anticancer Drugs / Vera V. Grinkevich, Andreas Warnecke and Galina Selivanova -- Targeting Mutant p53 for Improved Cancer Therapy / Jinfeng Shen, Vladimir J. N. Bykov and Klas G. Wiman -- p53 Immunotherapy of Cancer / Hakim Echchannaoui and Matthias Theobald -- Designing p53 Trials: A Surgical Oncologists View / Daniela Kandioler, Sonja Kappel and Brigitte Wolf -- p53 in the Clinic: A Pathologist's View / Philippe Bertheau, Jean-François Fléjou, Yves Allory, Pascale Varlet and Sylvie Lantuejoul, et al. -- Genetic Counseling for TP53 Germline Mutations / Maria Isabel Waddington Achatz and Patricia Ashton-Prolla.
  • This book provides an in-depth 'state-of-the-art' critical review of the technique and the applications of flexible and rigid bronchoscopy to infants and children. Written by an international panel of experts, it reviews the technical aspects of the procedure, its common and highly specialized applications as well as its potential alternatives. The chapters are enhanced by a wealth of original figures. A major innovation of the book is the inclusion of online videos from actual bronchoscopies that further illustrate and elaborate on the information provided in the text. The book is addressed to paediatric pulmonologists and otorhinolaryngologists, both experienced and in training, as well as to other personnel who are involved in the performance of the procedures. In addition, it is recommended to pulmonologists for adults and general paediatricians who need to be able to evaluate the usefulness of bronchoscopy for their patients and be aware of its limitations and potential contra-indications.
  • As patients live longer and need to be treated over the long term and the management of pediatric cardiology problems and congenital heart disease moves more into the mainstream, turn to Pediatric Cardiology for current clinical guidance. Trust Dr. Robert Anderson, godfather of cardiac morphology, to bring you coverage of potential cardiovascular anomalies, all potential diseases related to anomalies or developmental problems, and methods for management and treatment. New contributors from all over the world, including 70% new to this edition, present the latest challenges in the field and emphasize the adolescent and post-operative outcomes for management. Now, in full color and with a fully searchable companion website, this leading reference offers you everything you need to treat and manage pediatric heart conditions. A comprehensive and exhaustive reference of fundamental and clinical aspects of heart disease in infancy and childhood. The contributors are well-known experts in the field and the editors are a world class group who have published extensively in the field.
  • Print Material
  • The book presents a problem-based, rational approach to the diagnosis of orthopaedic problems in children. It is divided into five sections based on the age at which specific problems may be encountered; the newborn, the neonate and infant, the toddler and the pre-school child, the child in the school-going age and the adolescent. The authors outline a systematic approach to arrive at a tentative diagnosis by asking relevant questions related to the presenting symptom and then performing a thorough clinical examination. They then suggest the most appropriate investigations to confirm the diagnosis. Each chapter deals with the common conditions that may lead to the problem; the rarer causes of the problem are listed at the end.
  • This book provides the reader with a theoretical and practical understanding of two health care delivery models: the patient/child centred care and family-centred care. Both are fundamental to caring for children in healthcare organizations. The authors address their application in a variety of paediatric healthcare contexts, as well as the ethical and legal issues they raise. Each model is increasingly pursued as a vehicle for guiding the delivery of health care in the best interests of children. Such models of health care delivery shape health care policies, programs, facility design, resource allocation decisions and day-to-day interactions among patients, families, physicians and other health care professionals. To maximize the health and ethical benefits these models offer, there must be shared understanding of what the models entail, as well as the ethical and legal synergies and tensions they can create. This book is a valuable resource for paediatricians, nurses, trainees, graduate students, practitioners of ethics and health policy.
  • The peculiarities of infant respiratory physiology / Hammer, J., Eber, E. -- Tidal breathing measurements / Lodrup Carlsen, K.C., Carlsen, K.-H. -- Respiratory mechanics / Davis, S.D., Gappa, M., Rosenfeld, M. -- Forced expiratory flow-volume measurements / Modl, M., Eber, E. -- Infant whole-body plethysmography / Gappa, M., Heulskamp, G. -- Measurement of functional residual capacity and ventilation inhomogeneity by gas dilution techniques / Gustafsson, P.M., Ljungberg, H. -- Techniques for the measurement of lung function in toddlers and preschool children / Hall, G.L., Brookes, I.M. -- Applications and future directions of infant pulmonary function testing / Stocks, J., Lum, S. -- Spirometry: volume-time and flow-volume curves / Eber, E., Zach, M.S. -- Plethysmography and gas dilution techniques / Marchal, F., Schweitzer, C. -- Reference equations for ventilatory function measurements in children from 6 to 16 years / Merkus, P.J.F.M. -- Measurement of bronchial responsiveness in children / Barben, J., Riedler, J. -- Measurements of respiratory muscle function in children / Fauroux, B., Lofaso, F. -- Measurements of thoraco-abdominal asynchrony and work of breathing in children / Newth, C.J.L., Hammer, J. -- Lung diffusion capacity / de Jongste, J.C., Merkus, P.J.F.M., Stam, H. -- Measurement of exhaled nitric oxide / Kharitonov, S.A. -- Measurement of nasal nitric oxide / Corbelli, R., Hammer, J. -- Exhaled breath condensate and other markers in exhaled air / Moeller, A., Kielbasa, B. -- Childhood asthma and wheezing disorders / Basek, P., Straub, D., Wildhaber, J.H. -- Cystic fibrosis / Ratjen, F. -- Lung transplantation in pediatric patients / Tablizo, M.A., Woo, M.S. -- Neuromuscular disorders / Mellies, U., Dohna-Schwake, C. -- Paediatric oncology and bone marrow transplantation / Cerveri, I. ... [et al.] -- Long-term sequelae of neonatal lung disease / Trachsel, D., Coates, A.L. -- Pulmonary function testing in the neonatal and paediatric intensive care unit / Hammer, J., Newth, C.J.L.
  • Evolution, child development and the thyroid : a phylogenetic and ontogenetic introduction to normal thyroid function / Krude, H. -- Human fetal thyroid function / Polak, M. -- The role of thyroid hormones for brain development and cognitive function / Rovet, J. F. -- Neonatal screening for congenital hypothyroidism / Torresani, T. -- Diagnosis, treatment and outcome of congenital hypothyroidism / Van Vliet, G.; Deladoëy, J. -- Clinical genetics of congenital hypothyroidism / Szinnai, G. -- Central hypothyroidism in children / Garcí́a, M., Fernssndez, A., Moreno, J.C. -- Thyroid hormone cell membrane transport defect / Ramos, H.E. -- Resistance to thyroid hormone / Onigata, K., Szinnai, G. -- Iodine deficiency in children / Pearce, E.N. -- Thyroid autoimmunity / Wiersinga, W.M. -- Clinical aspects of Hashimoto's thyroiditis / Radetti, G. -- Graves' disease in children / Léger, J. -- Thyroid nodules and differentiated thyroid cancer / Bauer, A.J. -- Medullary thyroid carcinoma in children / Viola, D., Romei, C.; Elisei, R.
  • Print Material
  • Pain 2006
    Section 1. Pain and neurology -- Section 2. The neurobiology of pain -- Peripheral signaling of pain -- Spinal cord processing -- Supraspinal processing -- Endogenous pain modulation -- Section 3. The pathophysiology of pain -- Section 4. Pain assessment -- Neurophysiological examinations in neuropathic pain -- Section 5. Pain conditions in neurology: peripheral neuropathies -- Pain after nerve injury -- Facial pain -- Polyneuropathies and pain -- Section 6. Pain conditions in neurology: central neuropathic pain -- Section 7. Other pain conditions of neurological interest -- Section 8. Treatment of neuropathic pain -- Subject index.
  • Pain control 2015
    Emerging concepts of pain therapy based on neuronal mechanisms -- The pharmacology of nociceptor priming -- Sodium channels and pain -- Role of nerve growth factor in pain -- Central sensitization in humans: assessment and pharmacology -- Nitric oxide-mediated pain processing in the spinal cord -- The role of the endocannabinoid system in pain -- The role of glia in the spinal cord in neuropathic and inflammatory pain -- Plasticity of inhibition in the spinal cord -- Modulation of peripheral inflammation by the spinal cord -- The relationship between opiods and immune signalling in the spinal cord -- The role of proteases in pain -- Amygdala pain mechanisms -- Itch and pain differences and commonalities -- Index.
  • How do pain genes affect pain experience? / Marshall Devor -- Conservation of pain genes across evolution / Thang Manh Khuong and G. Greg Neely -- Defining human pain phenotypes for genetic association studies / Christopher Sivert Nielsen -- Genetic contributions to pain and analgesia : interactions with sex and stress / Roger B. Fillingim and Jeffrey S. Mogil -- Monogenic pain disorders / Geoff Woods -- Alternative pre-mRNAsplicing of mu opioid receptor gene: molecular mechanisms underlying the complex actions of mu opioids / Ying-Xian Pan -- Discovering multi-locus associations with complex pain phenotypes / Chia-Ling Kuo, Luda Diatchenko, Dmitri Zaykin -- Overlapping phenotypes : genetic contribution to nausea and pain / Charles C. Horn -- A counterpart to pain : itch / Adam P. Kardon and Sarah E. Ross -- Translating genetic knowledge into clinical practice for musculoskeletal pain conditions / Luda Diatchenko, Shad B. Smith, William Maixner -- The human chronic pain phenome : mapping non-genetic modifiers of the heritable risk / Ze'ev Seltzer, Scott R. Diehl, Hance Clarke and Joel Katz.
  • "Women are affected by many chronic pain conditions in overwhelmingly greater numbers than are men. They are also at higher risk of disability due to pain in all age groups. Addressing this problem with a comprehensive and practical examination of the problem, Pain in Women: A Clinical Guide is an important contribution to the literature on sex-based differences in illness and pain in particular. Developed by a renowned group of experts in pain medicine, this ... title is designed not only to review the basics of the current understanding of the biological differences between the sexes when it comes to pain conditions, but also to provide clinicians in varying fields with a guide that helps elucidate the proposed neuroanatomical and neurophysiological mechanisms that are currently understood to underlie these differences."
  • Print Material
    Pain management in interventional radiology : an introduction / Jason R. Bauer and Charles E. Ray, Jr. -- Clinical evaluation of low-back pain / Anthony P. Dwyer, Curt Freudenberger, and Vikas V. Patel -- Local anesthetics / Jan Namyslowski -- Functional lumbar spine anatomy : a review / Anthony P. Dwyer ... [et al.] -- Percutaneous vertebroplasty / Mitchell T. Smith and Charles E. Ray, Jr. -- Kyphoplasty / Frances D. Faro, Anthony P. Dwyer, and Vikas V. Patel -- Epidural steroid injections / Brian D. Petersen, Kirkland W. Davis, and James Choi -- Selective nerve root blocks / Brian Petersen, Kirkland W. Davis, and James Choi -- Discography / Charles E. Ray, Jr. and Leo J. Rothbarth -- Facet (zygapophyseal) joint injections / Nick Stence -- Articular interventions in pain management : a general approach / Blaze Cook -- Percutaneous management of visceral pain / Frank Morello -- Embolization of painful neoplasms / Jennifer R. Huddleston and Stephen P. Johnson -- Image-guided ablation of painful osteolyses / David T. Wang and Charles E. Ray, Jr. -- Chronic pelvic pain in women / Derek L. West -- Sedation and analgesia medications / George Behrens, Hector Ferral, and Nilesh H. Patel -- Guidelines for sedation administered by nonanesthesiologists / Iftikhar Ahmad -- Pediatric sedation for radiological imaging studies and interventions / Keira P. Mason -- Nontraditional pain management in interventional radiology / Salomao Faintuch ... [et al.] -- Postprocedural pain control / Stan Zipser.
  • No matter what questions arise in practice or while preparing for boards, Pain Management Secrets, 3rd Edition has the answers. A two-color page layout, portable size, and a list of the "Top 100 Secrets" in pain management help you better meet the challenges you face today. You'll find all the features you rely on from the Secrets Series®, a question-and-answer format, lists, mnemonics, tables and an informal tone, that make reference fast and easy. Expedites reference and review with a question-and-answer format, bulleted lists, mnemonics, and practical tips from the authors. Features a two-color page layout, "Key Points" boxes, and lists of useful web sites to enhance your reference power. Presents a chapter containing "Top 100 Secrets", providing you with an overview of essential material for last-minute study or self-assessment. Fits comfortably in the pocket of your lab coat so you have it conveniently on hand at all times.
  • Pain management is a vast subject and is changing rapidly. Finding a good resource for learning, however, is difficult. Most of the available books are lengthy volumes including many details irrelevant to physicians sitting for examinations or assessment. Furthermore, books aimed at assisting preparation for entire anaesthesia exams typically address pain management in only one chapter or a few pages. This book covers the entire curriculum relating to pain management and will make it easy to learn all aspects of the subject by covering key concepts in a reader-friendly manner. It comprises nine concise and simple chapters that aim to impart the maximum information within a limited space. These chapters address anatomy, assessment of pain, diagnosis of pain, pharmacology, non-pharmacological pain management, acute and chronic pain management, pain management in special groups, and special techniques. Pain Management: Essential Topics for Examinations will be an ideal resource for those who plan to sit for examinations, wherever they are based in the world. In addition, it will be an invaluable reference for higher and advanced pain trainees, residents, and physicians working in chronic pain.
  • Pain management. 2nd ed. 2011
    Conceptual Framework for Understanding Pain in the Human -- Anatomy of the Pain Processing System -- Dynamics of the Pain Processing System -- Central Pain Modulation -- History and Physical Examination of the Patient in Pain -- Patterns of Common Pain Syndromes -- Rational Use of Laboratory Testing -- Radiography -- Fluoroscopy -- Nuclear Medicine Techniques for Pain Management -- Computed Tomography -- A Practical Approach to Radiation Protection -- Magnetic Resonance Imaging -- Intervertebral Disc Stimulation Provocation Discography -- Myelography -- Epidurography -- Neural Blockade for the Diagnosis of Pain -- Differential Neural Blockade for the Diagnosis of Pain -- Spinal Canal Endoscopy -- Electromyography and Nerve Conduction Velocity Testing -- Evoked Potential Testing -- The Measurement of Pain: Objectifying the Subjective -- Neuropathic Pain: Neuropsychiatric, Diagnostic And Management Considerations -- Management of Acute and Postoperative Pain -- Burn Pain -- Sickle Cell Pain -- Acute Headache -- Evaluation and Treatment of Peripheral Neuropathies -- Acute Herpes Zoster and Post Herpetic Neuralgia -- Complex Regional Pain Syndrome Type I: Reflex Sympathetic Dystrophy -- Complex Regional Pain Syndrome Type II: Causalgia -- Phantom Pain Syndromes -- Identification and Treatment of Cancer Pain Syndromes -- Radiation Therapy in the Management of Cancer Pain -- Neural Blockade with Local Anesthetics and Steroids in the Management of Cancer Pain -- Neural Blockade with Neurolytic Agents in the Management of Cancer Pain -- The Role of Spinal Opioids in the Management of Cancer Pain -- Neurosurgery in the Management of Cancer Pain -- Palliative Care in the Management of Cancer Pain -- Common Sports Injuries -- Fibromyalgia -- Painful Neuropathies Including Entrapment Syndromes -- Osteoarthritis and Related Disorders -- The Connective Tissue Diseases -- Polymyalgia Rheumatica -- Migraine Headache -- Tension-Type Headache -- Cluster Headache -- Medication Overuse Headache -- Trigeminal Neuralgia -- Glossopharngeal Neuralgia -- Giant Cell Arteritis -- Pain of Ocular and Periocular Origin -- Pain of the Ear, Nose, Sinuses, and Throat -- Occipital Neuralgia -- Reflex Sympathetic Dystrophy of the Face -- Cervical Facet Syndrome -- Cervical Radiculopathy -- Brachial Plexopathy -- Cervical Myelopathy -- Cervical Dystonia -- Arthritis Pain of the Shoulder -- Disorders of the Rotator Cuff -- Acromioclavicular Joint Pain -- Subdeltoid Bursitis -- Biceps Tendinitis -- Scapulocostal Syndrome -- Tennis Elbow -- Golfer's Elbow -- Olecranon and Cubital Bursitis -- Entrapment Neuropathies of the Elbow and Forearm -- Arthritis of the Wrist and Hand -- Carpal Tunnel Syndrome -- DeQuervain's Tenosynovitis -- Dupuytren's Contracture -- Trigger Finger and Trigger Thumb -- Glomus Tumor of the Hand -- Chest Wall Pain Syndromes -- Thoracic Radiculopathy -- Painful Disorders of the Respiratory System -- Postmastectomy Pain -- Post-Thoracotomy Pain -- Mononeuritis Multiplex -- Abdominal Wall Pain Syndromes -- Acute and Chronic Pancreatitis -- Ilioinguinal, Iliohypostric, and Genitofemoral Neuralgia -- Low Back Pain -- Osteoporosis -- Lumbar Radiculopathy -- Lumbar Facet Syndrome -- Occupational Back Pain -- Infections of the Spine -- Arachnoiditis and Related Conditions -- Spondylosis and Spondylolisthesis -- Sacroiliac Joint Pain and Related Disorders -- Failed Back Surgery Syndrome -- Pelvic Girdle and Low Back Pain in Pregnancy -- Pelvic Girdle and Low Back Pain in Pregnancy -- Postoperative Deformities of the Dural Sac -- Osteitis Pubis -- Piriformis Syndrome -- Orchialgia -- Vulvadynia -- Coccyodynia -- Proctalgia Fugax -- Proctalgia Fugax -- Gluteal and Ischiogluteal Bursitis -- Trochanteric Bursitis -- Biceps Tendinitis -- Meralgia Paresthetica -- Femoral and Saphenous Neuropathy -- Obturator Neuropathy -- Painful Conditions of the Knee -- Bursitis Syndromes of the Knee -- Baker's Cyst -- Quadriceps Expansion Syndrome -- Arthritis of the Ankle and Foot -- Achilles Teninitis and Bursitis and Other Painful Conditions of the Ankle -- Morton's Neuroma and Other Painful Conditions of the Foot -- Hallux Valgus, Bunion, Bunionette, and Other Painful Conditions of the Toe -- Plantar Fascitis -- Simple Analgesics -- Nonsteroidal Anti-Inflammatory Drugs and the Cox-2 Inhibitors -- Opioid Analgesics -- Role of Antidepressants in the Management of Pain -- Anticonvulsant Compounds -- Centrally Acting Skeletal Muscle Relaxants and Associated Drugs -- Topical and Systemic Local Anesthetics -- Alternative Pain Medicine -- Limitations of Pharmacologic Pain Management -- Psychological Interventions -- Biofeedback -- Hypnosis -- Relaxation Techniques and Guided Imagery -- Therapeutic Heat and COld In the Management of Pain -- Hydrotherapy -- Hydrotherapy -- Transcutaneous Electrical Nerve Stimulation -- Osteopathic Manipulative Treatment of the Chronic Pain Patient -- Nociceptors, Pain and Spinal Manipulation -- Acupuncture -- Prolotherapy -- Atlanto-Occipital Block -- Atlantoaxial Injection -- Sphenopalatine Ganglion Block -- Greater and Lesser Occipital Nerve Block -- Third Occipital Nerve Block -- Gasserian Ganglion Block -- Blockade of the Trigeminal Nerve and Its Branches -- Glossopharyngeal Nerve Block -- Vagus Nerve Block -- Phrenic Nerve Block -- Cervical Plexus Block -- Stellate Ganglion Block -- Cervical Facet Block -- Cervical Epidural Nerve Block -- Lysis of Cervical Epidural Adhesions: Racz Technique -- Brachial Plexus Block -- Neural Blockade of the Peripheral Nerves of the Upper Extremity -- Suprascapular Nerve Block -- Thoracic Epidural Nerve Block -- Intercostal Nerve Block -- Splanchnic and Celiac Plexus Nerve Block -- Lumbar Epidural Injections -- Subarachnoid Neurolytic Block -- Lumbar Facet Block -- Lumbar Sympathetic Nerve Block -- Ilioinguinal-Iliohypogastric Nerve Block -- Lateral Femoral Cutaneous Nerve Block -- Obturator Nerve Block -- Caudal Epidural Nerve Block -- Lysis of Epidural Adhesions: The Racz Technique -- Hypogastric Nerve and Ganglion Impar Block -- Injection of the Sacroiliac Joint -- Neural Blockade of the Peripheral Nerves of the Lower Extremity -- Peripheral Nerve Stimulation -- Spinal Cord Stimulation -- Implantable Drug Delivery Systems: Practical Considerations -- Complications of Neuromodulation -- Neuroadenolysis of the Pituitary Gland -- Radiofrequency Lesioning -- Cryoneurolysis -- Vertebroplasty and Kyphoplasty -- Intradiskal Electrothermal Annuloplasty -- Percutaneous Discectomy-Automated Technique -- Percutaneous Laser Discectomy -- Percutaneous Fusion Techniques.
  • 2011 ClinicalKey
    Section I. Basic Principles of Procedures -- Section II. Soft Tissue & Joint Injections -- Section III. Complementary & Alternative Medical Procedures -- Section IV. Peripheral Nerve Blocks -- Section V. Spine -- Section VI. Physical Modalities for Pain Management.
  • Pain review 2009
    Dr. Steven Waldman, a noted authority in the multidisciplinary field of pain management, has assembled an excellent study guide for certifying or recertifying in pain management. A keyword-oriented review of the specialty, it offers the consistent approach and editorial style that make Dr. Waldman's books and atlases some of the most widely read in the field. An easy-access, templated approach helps you to access desired information quickly, and clear illustrations make difficult concepts easier to understand. Covering an exhaustive list of known and defined pain syndromes classified by body region, this is the one must-have book for anyone preparing for examinations. Expert Consult functionality allows you to access the entire contents of the book from any Internet connection. Provides a keyword-oriented review of pain medicine that closely follows the board style of examination and study. Maintains a consistent approach and editorial style as a single-authored text by noted authority Steven D. Waldman, MD. Utilizes a templated format so you access the information you need quickly and easily. Makes difficult concepts easier to understand using clear conceptual illustrations. Creates a virtual one-stop shop with an exhaustive list of known and defined pain syndromes classified by body region.
  • Introduction -- Measuring pain intensity -- Measuring pain quality -- Measuring pain location -- Measuring pain behavior -- Measuring pain interference -- Measuring sleep quality -- Measuring depression -- Measuring general physical functioning -- Measuring alcohol and drug use -- Measuring global improvement and satisfaction with pain care -- References.
  • This book presents a contemporary review of the field of Pain Therapeutics, including the historical medicines which still dominate standard of care treatments, as well as the new mechanisms and combinations/reformulations that have dominated the regulatory approvals over the last decade. In addition this book provides a deep review of the key biological mechanisms currently under investigation for their utility into the treatment of pain, such as ion channels, opiates and others. Additional discussion highlights the current challenges of pain research, covering a range of topics from difficulties in identifying new targets from pre-clinical models to the current regulatory and commercial challenges. This background sets the scene for recent scientific changes in pain research, such as the drive for genetic validation of targets and the derivation of human cell platforms from stem cells. Finally the book covers the discovery and development stories for two pain products approved in the last decade. These case studies for Lyrica and the Butrans patch, will give insight into the discovery and development challenges and successes for both an oral and non-oral product.
  • This book focuses on the reciprocal interactions between pain, emotion and cognition. International experts report on their findings, clinical experience and the most recent literature on the complex relations between these three domains. Clinical, psychological, behavioral and neuroimaging approaches converge towards aiding patients suffering from pain, cognitive impairment or emotional distress. Beyond the pathophysiological aspects of pain, difficulties encountered with patients are analyzed and strategies are proposed to optimize treatment, doctor-patient relationships, and patient well-being. This work will appeal to a broad readership, from clinical medical practitioners to psychologists, nurses and pain specialists.
  • There has been a step change in pain control in recent years thanks to improved imaging that allows for greater targeting of analgesia technique. However these procedures are not yet fully incorporated into practice. This book will take real-life photos from procedural steps allied to 3D CT anatomic scans to show the procedures towards effective pain management. Structured by anatomical location, the book will cover all the important interventional pain procedures in practice.
  • Introduction to Diabetic Neuropathies -- Classification and Clinical Features -- Diagnosis and Staging -- Management of Neuropathic Pain.
  • Painful diabetic polyneuropathy is the most common and disturbing of painful conditions experienced by people with diabetes. As the diabetes rate continues to grow, the number of people suffering from painful diabetic polyneuropathy will as well - increasing both patient suffering and demands on healthcare resources. Painful Diabetic Polyneuropathy covers all aspects of these painful disorders from pathophysiology and diagnosis, treatment and prevention, future approaches and the nursing perspective, to billing issues and the patient's experience.
  • 1. Functional maturation of PAKs from unicellular to multicellular organisms / Masato Okada, Graham Cote, Ramesh K. Jha, and Hiroshi Maruta -- 2. Oncogenicity of PAKs and their substrates / Hong He and Hiroshi Maruta -- 3. Natural or synthetic therapeutics that block PAKs / Hiroshi Maruta, Shanta M. Messerli, and Ramesh K. Jha -- 4. PAK1-3 in infectious diseases / Hiroshi Maruta -- 5. PAK1 in brain diseases or disorders / Hiroshi Maruta and Shanta M. Messerli -- 6. PAK1 in Alzheimer's and Huntington's diseases / Qui-Lan Ma, Fusheng Yang, Sally A. Frautschy, and Greg M. Cole -- 7. PAK1 controls the lifespan / Sumino Yamase and Hiroshi Maruta -- 8. 3D structure and physiological regulation of PAKs / Stefan Knapp.
  • Great plagues of the past and remaining questions / Cheston B. Cunha and Burke A. Cunha -- Identification and interpretation of historical cemeteries linked to epidemics / Dominique Castex -- Archaeological proof of an abrupt mortality crisis : simultaneous deposit of cadavers, simultaneous deaths? / Henri Duday -- Molecular detection of past pathogens / Michel Drancourt and Didier Raoult -- Histologic detection of past pathogens / Hubert Lepidi -- Palaeomicrobiology of tuberculosis / Helen D. Donoghue -- Past leprae / Andreas G. Nerlich and Albert R. Zink -- Archaeology of human pathogens : palaeopathological appraisal of palaeoepidemiology / Olivier Dutour -- Past plague / Michel Drancourt and Didier Raoult -- Typhoid fever epidemic in ancient Athens / Manolis J. Papagrigorakis, Christos Yapijakis and Philippos N. Synodinos -- Dental pulp as a tool for the retrospective diagnosis of infectious diseases / Vu Dang La ... [et al.] -- History of influenza pandemics / Bruno Lina -- Human lice : Pediculus and Pthirus / Kosta Y. Mumcuoglu.
  • Paleoradiology : history and new developments / Rethy K. Chhem -- Paleoradiologic techniques / George Saab, Rethy K. Chhem, and Richard N. Bohay -- The taphonomic process, biological variation, and x-ray studies / Don R. Brothwell -- Diagnostic paleoradiology for paleopathologists / Rethy K. Chhem, George Saab, and Don R. Brothwell -- Paleoradiology in the service of zoopaleopathology / Don R. Brothwell -- Normal variations in fossils and recent human groups / Don R. Brothwell -- Concluding comments / Rethy K. Chhem and Don R. Brothwell.
  • "This topical and timely text provides valuable insights into the choices and experiences of palliative and end of life care for young people with cancer and other life limiting illnesses. With a focus on palliative care provision across a range of different clinical settings, this comprehensive new resource explores care in the home, the hospice and hospital. It looks at how and where families and young people can access palliative care, and what support is offered to attain their preferred place of death. Bereavement support for families is discussed, as well as a discussion of multi-disciplinary work, interagency co-operation and resource issues. This will be essential reading for community children's nurses, specialist palliative care teams, children's hospices, school nurses, social workers and student nurses as well as families"--Provided by publisher.
  • Print Material
    Overview -- Trajectories and prognostication in emergency care -- Rapid palliative care assessment -- Cancer emergencies -- Malignant pain -- Non-malignant pain -- Symptom management -- Spiritual suffering and bereavement -- Communication -- Resuscitation, family presence, and last hours of living -- Hospice -- Legal and ethical issues of palliative care in the emergency.
  • Palliative care 2006
  • Global Palliative Care Issues / Marissa Slaven -- Palliative Care Communication Issues / Joshua Hauser -- Nutritional Palliative Care Issues / Clay M. Anderson -- Psychiatric Palliative Care Issues / Jane E. Loitman and Teresa Deshields -- Cardiac Palliative Care Issues / David Wensel and Drew A. Rosielle -- Pulmonary Palliative Care Issues / Karin B. Porter-Williamson -- GI Palliative Care Issues / Eric Roeland and Gary Buckholz -- Palliative Pain Issues / Miles J. Belgrade -- Palliative Wound and Skin Issues / Cynthia A. Worley -- Issues in the Last Hours / Jane E. Loitman and Christian T. Sinclair.
  • Introduction to Palliative Care -- Communication Skills -- Breaking Bad News -- Symptom Control -- Palliative Care Emergencies -- Advance Care Planning -- Ethical Issues -- Prescribing in Palliative Care.
  • Palliative care provides comprehensive support for severely affected patients with any life-limiting or life-threatening diagnosis. To do this effectively, it requires a disease-specific approach as the patients? needs and clinical context will vary depending on the underlying diagnosis. Experts in the field of palliative care and oncology describe in detail the needs of patients with advanced cancer in comparison to those with non-cancer disease and also identify the requirements of patients with different cancer entities. Basic principles of symptom control are explained, with careful attention to therapy for pain associated with either the cancer or its treatment and to symptom-guided antineoplastic therapy. Complex therapeutic strategies for palliative cancer patients are highlighted that involve both cancer- and symptom-directed options and address a range of therapeutic aims. Issues relating to drug use in palliative cancer care are fully explored, and a separate section is devoted to care in the final phase. A range of organizational and policy issues are also discussed, and the book concludes by considering likely future developments in palliative care for cancer patients. Palliative Care in Oncology will be of particular interest to palliative care physicians who are interested in broadening the scope of their disease-specific knowledge, as well as to oncologists who wish to learn more about modern palliative care concepts relevant to their day-to-day work with cancer patients.
  • 2011 ClinicalKey
    Find out all you need to know about providing high-quality care to patients with serious illnesses from the 2nd edition of Palliative Care: Core Skills and Clinical Competencies. Drs. Linda L. Emanuel and S. Lawrence Librach, leaders in the field, address the clinical, physical, psychological, cultural, and spiritual dimensions that are integral to the care of the whole patient. They give you a broad understanding of the core clinical skills and competencies needed to effectively approach patient assessment, care of special populations, symptom control, ethical issues, and more. Clearly written in a user-friendly, high-yield format with convenient online access, this resource is your ultimate guidebook to the burgeoning practice of palliative medicine. Improve your pain management and symptom management skills with a better understanding of best practices in palliative care. Quickly review specific treatment protocols for both malignant and non-malignant illnesses, including HIV/AIDS, heart failure, renal failure, pulmonary disease, and neurodegenerative disease. Better understand and manage the common and unique challenges associated with delivering palliative care in various social settings, such as the ICU, hospice, and the home; and to diverse populations, such as children, elders, and vulnerable members of society.
  • Palliative medicine 2009
  • Section I. Palliative management -- Introduction to palliation -- Characteristics of palliation -- Nodal points in decision-making -- Common deficiencies in palliative management -- Common themes in palliation practice -- Section II. Major discomforts in advanced neurological illness -- Fatigue -- Problems with muscles and movement -- Bulbar symptoms -- Respiratory symptoms -- Gastrointestinal symptoms -- Urological symptoms -- Pain -- Cognitive, behavioural and psychological symptoms -- Miscellaneous symptoms -- Section III. Major neurological conditions requiring palliation -- Cerebrovascular diseases : stroke -- Demyelinating diseases -- Parkinson's disease and related disorders -- Dementia -- Amyotrophic lateral sclerosis (motor neurone disease) -- Incurable infections of the nervous system -- Muscular dystrophy -- Neuropathies -- Huntington's disease -- Cerebral neoplasms -- Sequelae of traumatic brain injury -- Section IV. Ethical Issues -- Consent and decision-making -- Advance directives -- Proxy decision-making -- Ethical issues in states of disordered consciousness -- Terminal sedation -- Euthanasia -- Section V. Appendices.
  • Palliative surgery 2014
    Palliative surgery can greatly contribute to improving symptom control and quality of life for terminal cancer patients. Owing to the advanced stage of the disease, however, this type of surgery is also associated with significant morbidity and mortality. It is therefore important for surgeons to have a sound understanding of the medical and scientific background underlying treatment decisions in palliative surgery, a foundation that this book provides. The opening chapters examine the relationship between palliative medicine and palliative surgery and address general issues including pain management and anesthesiological considerations. The role of palliative surgery in a wide range of disease settings is then thoroughly explored, including detailed information on surgical techniques and their indications and outcomes. This book will be an invaluable resource for all who wish to learn more about the emerging role of palliative surgery.
  • Introduction: Rationale for Precision Medicine Clinical Trials.- The Key Role of Pathology in the Context of Precision Medicine Trials -- Basis for Molecular Genetics in Cancer -- Microarrays Based Molecular Profiling to Identify Genomic Alterations -- High Throughput Technologies: DNA and RNA Sequencing Strategies and Potential -- Bioinformatics for Precision Medicine in Oncology -- Assessment of Biomarkers? Predictive Value of Efficacy -- Designs for Evaluating Precision Medicine Trials -- Conclusions and Perspectives: Challenges for the Clinical Implementation of Precision Medicine Trials.
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    "Panaceia's Daughters provides the first book-length study of noblewomen's healing activities in early modern Europe. Drawing on rich archival sources, Alisha Rankin demonstrates that numerous German noblewomen were deeply involved in making medicines and recommending them to patients, and many gained widespread fame for their remedies. Turning a common historical argument on its head, Rankin maintains that noblewomen's pharmacy came to prominence not in spite of their gender but because of it. Rankin demonstrates the ways in which noblewomen's pharmacy was bound up in notions of charity, class, religion, and household roles, as well as in expanding networks of knowledge and early forms of scientific experimentation. The opening chapters place noblewomen's healing within the context of cultural exchange, experiential knowledge, and the widespread search for medicinal recipes in early modern Europe. Case studies of renowned healers Dorothea of Mansfeld and Anna of Saxony then demonstrate the value their pharmacy held in their respective roles as elderly widow and royal consort, while a study of the long-suffering Duchess Elisabeth of Rochlitz emphasizes the importance of experiential knowledge and medicinal remedies to the patient's experience of illness." --Publisher's description.
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  • Pancreatic cancer 2008
  • Pancreatic cancer 2010
    v. 1. Chapters 1-25 -- v. 2. Chapters 26-54.
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    Anatomy of the pancreas / Mary Kay Washington -- -- Pathology of the exocrine pancreas / Ralph H. Hruban, Syed Z. Ali -- Molecular genetic alterations in cancer-associated genes / Michiel S. van der Heijden, Scott E. Kern -- Molecular signal pathways in pancreatic cancer / Nabeel Bardeesy -- Pancreatic development / John W. Lin, Steven D. Leach -- Mouse-models of exocrine pancreatic cancer / Eric P. Sandgren -- Epidemiology / Donghui Li, Li Jiao -- Hereditary pancreatitis and its link to pancreatic cancer / Saima Sharif ... [et al.] -- Familial pancreatic cancer / Ralph Hruban ... [et al.] -- Prevention / Marsha L. Frazier -- -- Pancreatic cancer: clinical presentation / Vincent J. Picozzi -- Radiographic imaging: CT/MR/PET / Eric Tamm ... [et al.] -- Endoscopic staging: EUS, ERCP / Richard A. Erickson -- Laparoscopic staging / Olga N. Tucker, Kevin C. Conlon -- Fine-needle aspiration biopsy of the pancreas: indications and interpretations / Gregg A. Staerkel Clinical trial design and methodology / Jason A. Konner, Eileen M. O'Reilly -- Supportive care: symptom management / Suresh K. Reddy, Ahmed Elsayem, Rudranath Talukdar -- Supportive care: cachexia and anorexia syndrome / Michael J. Tisdale -- -- Target discovery: genomics/proteomics / Christine A. Iacobuzio-Donahue -- Gene therapy and virotherapy of pancreatic cancer / Masato Yamamoto, David T. Curiel -- Antiangiogenic therapy for pancreatic cancer / Chandrajit P. Raut, Lee M. Ellis -- Vaccines / Daniel A. Laheru, Elizabeth M. Jaffe -- Serologic diagnosis of pancreatic cancer / Matthew H. Katz, Abdool R. Moossa, Michael Bouvet -- The Molecular diagnosis of pancreatic cancer / Michael G. Goggins -- -- Pancreaticoduodenectomy / Tina W. F. Yen ... [et al.] -- The Role of total pancreatectomy in the treatment of pancreatic cancer / John D. Christein, Michael B. Farnell -- Distal pancreatectomy / Scott F. Gallagher, Emmanuel E. Zervos, Michel M. Murr -- Pylorus preservation versus standard pancreaticoduodenectomy / Taylor S. Riall, Charles J. Yeo -- Pancreaticoduodenectomy with en bloc vascular resection and reconstruction for localized carcinoma of the pancreas / Charles R. Scoggins, Jeffrey E. Lee, Douglas B. Evans -- Reducing the risk of pancreaticoduodenectomy / Laura A. Lambert, John D. Birkmeyer -- Interventional radiology in the management of postoperative complications / Michael J. Wallace, Stephen McRae The Principles of chemoradiation in localized pancreatic cancer / Christopher H. Crane -- Adjuvant and neoadjuvant therapies for resectable pancreatic cancer / Robert A. Wolff -- Postoperative adjuvant therapy and the rationale for the U.S. intergroup trial / Young Kwok, Michael C. Garofalo, William F. Regine -- Intraoperative electron beam irradiation in pancreatic cancer / Christopher G. Willett, Peter J. Biggs, Carlos Fernández-del Castillo -- -- Systemic therapy and chemo-radiotherapy / Ross A. Abrams -- Endoscopic palliation of pancreatic cancer / David Whitaker, Benedict M. Deveraux -- Surgical palliation of pancreatic cancer / Michael L. Kendrick ... [et al.] -- -- Advanced metastatic disease / Marcel Rozencweig, Daniel D. Von Hoff Tumors of the endocrine system / David S. Klimstra -- Sporadic gastrinoma / Chandu Vemuri, Gerard M. Doherty -- Rare functioning tumors: VIPoma, glucagonoma, somatostatinoma / Geoffrey B. Thompson -- Pancreatic endocrine neoplasms in multiple endocrine neoplasia type 1 / Maria A. Kouvaraki ... {et al.] -- The von Hippel-Landau syndrome / Eric Jonasch -- Non-functioning pancreatic endocrine tumors / Carmen C. Solorzano, Jeffrey E. Lee -- Management of metastatic islet cell carcinoma / James C. Yao, Maria A. Kouvaraki, Sanjay Gupta -- -- Pathology of periampullary tumors / Mari Mino, Gregory Y. Lauwers -- Clinical management of ampullary tumors / Rebekah R. White ... [et al.] -- -- Pathological classification of cystic neoplasms of the pancreas / N. Volkan Adsay -- Imaging of cystic pancreatic tumors / Chusilp Charnsangavej, Eric P. Tamm -- Surgical treatment of cystic neoplasms / Carlos Fernández-del Castillo -- -- Tumors of the distal common bile duct / Jorge Abores-Saavedra.
  • This book provides a thorough overview of the detection of PCNs using modern imaging techniques and a clear guide to the recognition of the different subtypes of PCN based on their radiologic and histopathologic features. This volume will serve as an excellent aid to the selection of optimal therapeutic strategies based on preoperative diagnosis. A further important feature is the emphasis placed on radiologic, clinical, and surgical correlations. Pancreatic cystic neoplasms (PCNs) have been increasingly recognized during the past decade, mainly because of the widespread use of modern imaging modalities for the investigation of often unrelated abdominal symptoms. The three most common subtypes of PCN are serous cystic neoplasms, mucinous cystic neoplasms, and intraductal papillary mucinous neoplasms. These subtypes have distinct radiologic and histopathological features, and their biological behavior differs greatly. Accurate preoperative diagnosis is of prime importance in selecting the optimal therapeutic strategy: while serous cystic neoplasms are almost always benign, and may be treated conservatively, mucinous cystic neoplasms and intraductal papillary mucinous neoplasms have malignant potential, warranting an aggressive surgical approach, i.e., pancreatectomy. Pancreatic Cystic Neoplasms will be of great interest to surgeons, gastroenterologists, radiologists, oncologists, and pathologists, and also to internists and residents in these specialties.
  • Introduction to Pancreatic Cytopathology -- Pancreatic Cytopathology: A Pragmatic Approach -- Pancreatic Ductal Adenocarcinoma and Its Variants -- Ancillary Testing for the Diagnosis of Pancreatic Ductal Adenocarcinoma -- Acinar Cell Carcinoma -- Pancreatoblastoma -- Solid-Pseudopapillary Neoplasm -- Pancreatic Endocrine Tumors -- Cystic Muscus-Producing Neoplasia: Intraductal Papillary Mucinous Neoplasms and Mucinous Cystic Neoplasms -- Other Cystic Lesions of the Pancreas -- Inflammatory Disease of the Pancreas -- Secondary Malignancies of the Pancreas.
  • Part 1. Potential Trials in Acute Pancreatitis -- Acute Pancreatitis in Intensive Care / John Kinsella, Barry Clements, Euan Dickson, Thierry Dugernier and Martin Hughes -- Antibiotic Prophylaxis in Acute Severe Pancreatitis: Should We Have a Further Study? / Jens Werner, Kevin C. P. Conlon, Hjalmar C. van Santvoort, Caroline S. Verbeke and Sakhawat H. Rahman -- Designing an Optimal Study for the Management of Infected Pancreatic Necrosis / Marc G. H. Besselink, Hjalmar C. van Santvoort, Ross Carter, Richard M. Charnley and Damian J. Mole, et al. -- Nutrition in Acute Pancreatitis / Hemant M. Kocher, Christos Dervenis, Attila Oláh, William R. Murray and Barry Clements, et al. -- An Optimal Randomized Study for Pain Control in Acute Pancreatitis / Åke Andrén-Sandberg, Julia V. Mayerle, Ajith K. Siriwardena, David P. Berry and Gareth R. Kirk, et al. -- Part 2. Potential Trials in chronic Pancreatitis -- Endoscopic Versus Surgical Drainage for Chronic Pancreatitis / Stephen P. Pereira, Shivi S. Siva and Colin D. Johnson -- Duodenum-Preserving Pancreatic Resection with Pancreatic Duct Drainage: What Is the Role of Supraduodenal Biliary Drainage? / Emre F. Yekebas, Christos Dervenis, Richard M. Charnley, Bettina M. Rau and Jens Werner, et al. -- Part 3. Potential Trials in Pancreatic Cancer -- Pain Management and Nutritional Support in Nonresectable Pancreatic Cancer / David P. Berry, Richard M. Charnley, Christos Dervenis, Gareth R. Kirk and Francis Regan, et al. -- Endoscopic Therapy in the Palliation of Nonresectable Pancreatic Cancer / Attila Oláh, William R. Murray, Colin J. McKay, Åke Andrén-Sandberg and Sakhawat H. Rahman, et al. -- Pancreatic Endocrine Tumors / Damian J. Mole, Caroline S. Verbeke and Nicholas S. Reed -- The Role of the Systemic Inflammatory Response in Predicting Outcome in Patients with Pancreatic Cancer / Donald C. McMillan -- Part 4. Topic reviews -- Botulinum Toxin and the Sphincter of Oddi / William R. Murray -- The European Study Group for Pancreatic Cancer (ESPAC) Trials / Paula Ghaneh, Khaled Dajani, Michael G. T. Raraty, Robert Suttton and John P. Neoptolemos.
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  • Epidemiology and pathophysiology of acute pancreatitis / Anil B. Nagar and Fred S. Gorelick -- Diagnosis and risk stratification of acute pancreatitis / Frank Burton -- Gallstone pancreatitis / Matthias Kraft and Markus M. Lerch -- Other causes of acute pancreatitis / Charles D. Ulrich -- Treatment of mild acute pancreatitis and prevention of post-ERCP pancreatitis / Michael Morelli and Lehel Somogyi -- Treatment of severe acute pancreatitis / Peter Draganov -- Pancreatic necrosis and infections in patients with acute pancreatitis / Michael L. Kendrick and Michael G. Sarr --Pancreatic fluid collections and pseudocysts in patients with acute pancreatitis / Michael F. Byrne and John Baillie -- Epidemiology of chronic pancreatitis / Albert B. Lowenfels and Patrick Maisonneuve -- Risk, etiology, and pathophysiology of chronic pancreatitis / David C. Whitcomb -- Natural history of chronic pancreatitis / Supot Pongprasobchai and Jonathan E. Clain -- Diagnosis of chronic pancreatitis / Chris E. Forsmark -- Treatment of chronic pancreatitis pain: overview and medical management / Phillip P. Toskes -- Endoscopic approach to chronic pancreatitis / Lee McHenry, Glen Lehman, and Stuart Sherman -- Surgery for chronic pancreatitis / Martin D. Smith, Elias Degiannis, and Selwyn M. Vickers --Treatment of exocrine pancreatic insufficiency / Supot Pongprasobchai and Eugene P. DiMagno -- Complications of chronic pancreatitis / John Petersen and Chris E. Forsmark.
  • Influenza pandemics are unpredictable but recurring events that can have severe consequences on societies worldwide. This revised WHO guidance publication on pandemic influenza preparedness and response acknowledges that pandemic preparedness is centered around health sectors planning but must also be broader. WHO therefore advocates a "whole-of-society" approach to sustainable and ethical pandemic preparedness while focusing in more detail on the role of the health sector. The roles of WHO and national governments are outlined to create a better understanding of how health and non-health sectors, both public and private, all contribute to pandemic preparedness.--Publisher's description.
  • Pandemic planning 2012
    "The impact of an influenza pandemic can be measured in a variety of ways 50 million deaths in 1918 and 1919; hundreds of millions of individual cases of sickness in 1957; and an estimated three to four trillion dollars lost in global productivity in 2009. By their very nature, the characteristics and outcomes of future pandemics are extremely difficult to predict. This uncertainty, however, should not be viewed as a reason to avoid planning, but rather as a motivator to emphasize the necessity of thorough, complete, and flexible plans for the inevitable pandemics of the future. By improving the readiness of your organization to operate during a pandemic, the likelihood is increased that you will be able to respond quickly and appropriately to future events. Preparedness requires cooperation and collaboration on multiple levels. Individuals should protect themselves and their families; employers should enact policy changes to avoid the spread of illness in the workplace and in schools; healthcare providers and governmental bodies should exercise to test themselves and their communities. True preparedness requires multilevel commitments across geographic and organizational borders. Pandemics result in urgent needs and demands and resources will be limited. To be effective during the real event, this requires us to train and exercise the necessary skills and create plans before the crisis. It is imperative to develop and implement clear metrics for both individual and organizational performance. The ultimate purpose of planning and preparing for a pandemic is twofold: (a) to decrease the morbidity and mortality rates of the illness, and (b) to improve recovery time so that economic and social activities can be resumed at their normal levels"--Provided by publisher.
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    "From HIV to H1N1, pandemics pose one of the greatest threats to global health in the twenty-first century. Defined as epidemics of infectious disease across large geographic areas, pandemics can disseminate globally with incredible speed as humans and goods move faster than ever before. While restricted travel, quarantine, vaccines, drugs, and education can reduce the severity of many outbreaks, factors such as global warming, population density, and antibiotic resistance will complicate our ability to fight disease. Respiratory infections like influenza and SARS spread quickly as a consequence of modern, mass air travel, while unsafe health practices promote the spread of viruses like HIV/AIDS and hepatitis C. In Pandemics: What Everyone Needs to Know, Nobel Prize-winning immunologist Peter Doherty addresses the history of pandemics and the ones that persist today, what promotes global spread, types of pathogens and the level of threat they pose, as well as how to combat outbreaks and mitigate their effects"--Provided by publisher.
  • Vascular management and care has become a truly multidisciplinary enterprise. As a result of scientific progress, the number of specialists involved in the treatment of patients with vascular diseases is steadily increasing. While in the past, treatments were delivered by individual specialists, in the twenty-first century a team approach is without doubt the most effective strategy. Depending on the clinical manifestations, cardiologists, cardiac surgeons, vascular specialists, angiologists, radiologists, vascular surgeons, neurologists, neurointerventionalists, lipidologists, blood coagulation specialists, and diabetologists, to name but a few, may be involved. In order to promote professional excellence in this dynamic and rapidly evolving field, a shared knowledge base and interdisciplinary standards need to be established. PanVascular Medicine, 2nd edition℗ℓhas been designed to offer such an interdisciplinary platform, providing vascular specialists with state-of-the-art descriptive and procedural knowledge. Basic science, diagnostics, and therapy are all comprehensively covered. In a series of succinct, clearly written chapters, renowned specialists introduce and comment on the current international guidelines and present up-to-date reviews of all aspects of vascular care.℗ℓ℗ℓ℗ℓ℗ℓ℗ℓ
  • Overview of Diagnostic Terminology and Reporting -- Category I: Non-Diagnostic -- Category II: Negative (for Malignancy) -- Category III: Atypical -- Category IV: Neoplastic-Benign -- Category IV: Neoplastic-Other -- Category V: Suspicious (for Malignancy) -- Category VI: Positive or Malignant -- Appendix A: Template for Cyst Diagnosis -- Appendix B: Mucinous Etiology -- Appendix C: Useful Ancillary Tests.
  • Papillomaviruses 2007
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    v. 1. The Polyomaviruses.
  • The Role of Paradigms in Science and Theory Construction / William A. Hillix and Luciano L'Abate -- The Role of Paradigms in Science: A Historical Perspective / Corinna Guerra, Mario Capitelli, and Savino Longo -- Evolving Scientific Paradigms: Retrospective and Prospective / Willis F. Overton -- Anthropology / Luciano L'Abate -- Parallel Paradigms of Artists and Authors / Laura G. Sweeney -- Economics / Luciano L'Abate -- Education / Laura G. Sweeney -- Sociology / Alberto L'Abate -- Biopsychosocial / Beatrice L. Wood -- Interbehaviorism / Mitch J. Fryling and Linda J. Hayes -- Reflections on Personality Systematics and a Unified Clinical Science / Jeffrey J. Magnavita -- The Systemic Paradigm: The Intersubjective-Narrative Approach Versus the Relational-Generational One / Vittorio Cigoli and Eugenia Scabini -- Constructivism / Alexander Riegler -- Materialism / Luciano L'Abate -- Explicating and Exemplifying Empiricist and Cognitivist Paradigms in the Study of Human Learning / Sandra M. Loughlin and Patricia A. Alexander -- Humanism and Behaviorism / David Ryback -- Existentialism / Mario Cusinato -- Information Processing / Piero De Giacomo, Luisa Mich, Carlos Santamaria, Laura G. Sweeney, and Andrea De Giacomo -- Reductionism -- Gary G. Berntson and John T. Cacioppo -- Produced and Spontaneous Emergent Interactionism / Walter Colesso -- The Emergence of Reason, Intelligence, and Language in Humans and Animals / William A. Hillix, Duane M. Rumbaugh, and E. Sue Savage-Rumbaugh -- Essentialism / Luciano L'Abate -- Criteria and Processes in Paradigm Selection / Luciano L'Abate and Laura G. Sweeney.
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    Parallel and evolutionary approaches to computational biology / Nouhad Rizk -- Parallel Monte Carlo simulation of HIV molecular evolution in response to immune surveillance / Jack da Silva -- Differential evolutionary algorithms for in vivo dynamic analysis of glycolysis and pentose phosphate pathway in Escherichia coli / Andrei Doncescu -- Compute-intensive simulations for cellular models / Kevin Burrage -- Parallel computation in simulating diffusion and deformation in human brain / Jun Zhang -- Computational molecular biology / Azzedine Boukerche -- Special-purpose computing for biological sequence analysis / Bertil Schmidt -- Multiple sequence alignment in parallel on a cluster of workstations / Amitava Datta -- Searching sequence databases using high performance BLASTs / Xue Wu -- Parallel implementations of local sequence alignment: hardware and software / Vipin Chaudhary -- Parallel computing in the analysis of gene expression relationships / Robert Martino -- Parallel algorithms for solving the fragment assembly problem in DNA strands / Enrique Alba -- A cooperative genetic algorithm for knowledge discovery in microarray experiments / Mohammad Khabzaoui -- Parallel and distributed computation of large phylogenetic trees / Alexandros P. Stamatakis -- Phylogenetic parameter estimation on COWs / Ekkehard Petzold -- High-performance phylogeny reconstruction under maximum parsimony / Tiffani Williams -- Protein folding with the parallel replica exchange molecular dynamics method / Ruhong Zhou -- High performance alignment methods for protein threading / R. Andonov -- Parallel evolutionary computations in discerning protein structures / Richard O. Day -- A brief Overview of Grid activities for bioinformatics and health applications / Ali Al Mazari -- Parallel algorithms for bioinformatics / Shahid H. Bokhari -- Cluster and grid infrastructure for computational chemistry and biochemistry / Kim K. Baldridge -- Distributed workflows in bioinformatics / Arun Krishnan -- Molecular structure determination on a computational and data grid / Russ Miller -- GIPSY : a problem solving environment for bioinformatics applications / Rajendra R. Joshi -- TaskSpaces : a software framework for parallel bioinformatics on computational grids / Hans De Sterck -- The organic grid : self-organizing computation on desktop grids / Arjav J. Chakrvarti -- FPGA Computing in modern bioinformatics / H. Simmler -- Virtual microscopy : distributed image storage, retrieval, analysis, and visualization / T. Pan
  • Mating types in paramecium -- General description of the protista and of paramecium -- Methods of studying genetic processes in organisms of the paramecium Aurelia species group -- The determination of mating types in paramecium -- Symbionts and mitochondria of paramecium -- Determination of i-antigens -- Micronuclei and macronuclei -- Ribosomal RNA and DNA -- Cortical morphogenesis -- Behavior -- Epigenetics.
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    History -- Clinical findings, treatment and prognosis -- Pathogenesis -- Brain (cerebrum) -- Brain (cerebellum and brainstem) -- Spinal cord -- Cranial nerves -- Dorsal root ganglia and peripheral nerves -- Neuromuscular junction and muscle -- Systemic syndromes (with neurologic implications) -- Nuclear/nucleolar antibodies -- Cytoplasmic antibodies -- Synaptic/channel antibodies -- Anti-retinal/optic nerve antibodies -- Thoracic cancers -- Breast/gynecologic/testicular cancer -- Hematologic cancers/miscellaneous solid tumors.
  • Most parasitic diseases occur in tropical and subtropical regions, but some, such as toxoplasmosis and cryptosporidiosis, are endemic or rapidly emerging elsewhere, including the United States and Europe. Diagnosis is often difficult as the clinical manifestations of many parasitic lung diseases are similar to those of common respiratory illnesses and routine tests can fail to detect the infections. The relative rarity of these diseases increases the challenges faced by clinicians and pathologists. Parasitic Diseases of the Lungs is designed as a practical guide for pathologists who encounter parasitic diseases of the lung in their daily routine. The book comprises eight chapters. After discussion of the handling of lung biopsies from patients with suspected parasitic disease, individual chapters focus on Protozoa, Nematoda, Trematoda, and Cestoda. The morphologic patterns associated with various parasitic infections are then analyzed, and differentiation between artifacts and parasites is discussed. The final chapter is devoted to the immunocompromised patient and covers general principles of histologic evaluation, parasites associated with HIV and AIDS, and the features of diffuse alveolar damage.
  • "Parasitoids are parasitic insects that kill their insect hosts in immature pre-reproductive stages. Parasitoids are employed in biological control programs worldwide to kill insect pests and are environmentally safe and benign alternatives to chemical pesticides. As resistance to chemical pesticides continues to escalate in many pest populations, attention is now refocusing on biologically based strategies to control pest species in agriculture and forestry as well as insect vector populations that transmit human and animal diseases. Parasitoids are an economically critical element in this equation and in integrated pest management. Viruses have evolved intimate associations with parasitoids, and this book features a large section on symbiotic viruses that are integrated into the wasp chromosomal DNA (polydnaviruses). A separate section on parasitoid venoms, which are of interest to the pharmaceutical and medical communities as well as insect-oriented biologists, is also featured"--Back cover.
  • "The first authoritative review on the parasomnias - disorders that cause abnormal behavior during sleep - this book contains many topics never before covered in detail. The behaviors associated with parasomnias may lead to injury of the patient or bed-partner, and may have forensic implications. These phenomena are common but often unrecognized, misdiagnosed, or ignored in clinical practice. With increasing awareness of abnormal behaviors in sleep, the book fulfils the need for in-depth descriptions of clinical and research aspects of these disorders, including differential diagnosis, pathophysiology, morbidity, and functional consequences of each condition, where known. Appropriate behavioral and pharmacological treatments are addressed in detail. There are authoritative sections on disorders of arousal, parasomnias usually associated with REM sleep, sleep-related movement disorders and other variants, and therapy of parasomnias. Sleep specialists, neurologists, psychiatrists, psychologists and other healthcare professionals with an interest in sleep disorders will find this book essential reading"--Provided by publisher.
  • Part I. Overview -- Introduction -- Pathophysiology of parasomnias -- Classification of parasomnias -- Diagnosing parasomnias -- Part II. Clinical characteristics of arousal disorders -- Sleepwalking and its variants in adults -- Sleepwalking in children and adolescents -- Sleep terrors and confusional arousals in adults -- Sleep terrors and confusional arousals in children and adolescents -- Part III. Clinical characteristics of sleep-wake transition disorders -- Sleep starts and sleep talking -- Part IV. Clinical characteristics of parasomnias associated with REM sleep -- Physiology and content of dreams -- Nightmare disorders in adults -- Nightmare disorders in children -- Recurrent isolated sleep paralysis (RISP) -- Sleep-related hallucinations -- REM behavior disorder in adults -- REM behavior disorder in children -- Part V. Other parasomnias -- Nocturnal paroxysmal dystonia -- Sleep related dissociative disorders -- Sleep bruxism -- Nocturnal enuresis -- Sleep-related eating disorders: a separate entity or part of the NES clinical spectrum? -- Parasomnia overlap disorder -- Part VI. Neurological, psychiatric and medical disorders presenting as parasomnias -- Neurological conditions associated with parasomnias -- Psychiatric disorders presenting with parasomnias -- Medical disorders presenting with parasomnias -- Parasomnias caused by other conditions -- Part VIII. Interventions for parasomnias -- Treatment of parasomnias -- Use of alternative medicines in parasomnias for adults and children -- Part VIII. Medioclegal aspects -- Sexxomnia: a medicolegal case-based approach in analyzing potential sleep-related abnormal sexual behaviors -- Forensic aspects of the parasomnias.
  • Embryonic development and anatomic and histological structure of the parathyroid glands -- Preoperative imaging of the parathyroid glands -- Intraoperative imaging of the parathyroid glands -- Image-Guided minimally invasive modalities in surgical treatment of parathyroid diseases.
  • 1. Overview of parent-child interaction therapy -- 2. Research on PCIT -- 3. Intake assessment and therapy orientation session -- 4. Teaching child-directed interaction -- 5. Coaching child-directed interaction -- 6. Teaching parent-directed interaction -- 7. Coaching parent-directed interaction -- 8. Progressing through the parent-directed interaction sessions -- 9. Younger children -- 10. Older children -- 11. Siblings -- 12. Autism spectrum disorders -- 13. Child physical abuse -- 14. Anxiety disorders -- 15. Attention Deficit Hyperactivity Disorder -- 16. Extremely aggressive and explosive children -- 17. Marital conflict -- 18. Parents with major life stressors -- 19. Ethnic minority children and families -- 20. Staff-child interaction therapy -- 21. Teacher-child interaction therapy for preschool classrooms -- 22. School consultation -- 23. Home-based PCIT: from the lab to the living room -- 24. PCIT around the world -- 25. Training issues -- Appendices -- Subject Index.
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    v.1. For parents of children under school age.
  • Park's Pediatric Cardiology for Practitioners is the essential medical reference book for the ever-changing field of pediatric cardiology. Comprehensive in its content, it provides the practical guidance you need to diagnose and manage children with congenital and acquired heart disease. From history and physical examination through preventative treatment and the management of special problems, the fully revised 6th edition incorporates all of the latest concepts in cardiology, distilled in a way that is understandable to pediatricians, family practitioners, NPs, and PAs alike. Apply the latest knowledge and methods with coverage of surgical techniques in pediatric cardiology, the application of interventional non-surgical techniques, blood pressure standards, and cardiac arrhythmia treatments. Easily grasp the latest techniques with helpful line drawings throughout. Select the best approaches for your patients with extensive coverage of special problems, including congestive heart failure and syncope.
  • Top experts from all over the world have been brought together by the editors, to give a world of expertise on this important subject, with a strong emphasis on therapy and management.
  • Part I: Behavioral dysfunction in Parkinson's Disease -- Part II: Autonomic dysfunction in Parkinson's Disease -- Part III: Sleep-related dysfunction in Parkinson's Disease -- Part IV: Sensory dysfunction in Parkinson's Disease -- Part V: Other nonmotor dysfunction in Parkinson's Disease.
  • Parkinson's disease : diagnosis, motor symptoms and non-motor features / Joseph Jankovic -- Redefining Parkinson's disease / Charles H. Adler & Matthew B. Stern -- Motor features of Parkinson's disease / Ainhi D. Ha, Samuel D. Kim & Victor S.C. Fung -- Olfaction, pain and other sensory abnormalities in Parkinson's disease / Antoniya Todorova & Kallol Ray Chaudhuri -- Cognitive and behavioral abnormalities in Parkinson's disease / Laura Marsh -- Autonomic dysfunction in Parkinson disease / Lucy Norcliffe-Kaufmann & Horacio Kaufmann -- Biomarkers for Parkinson's disease / Andrew Siderowf -- Animal models of Parkinson's disease / Weidong Le & Joseph Jankovic -- Differentiating Parkinson's disease from other Parkinsonian disorders / Joseph Jankovic -- Multiple choice questions : answers.
  • Parkinson's disease : medical and surgical treatment / Joseph Jankovic -- Prevention of Parkinson's disease : preparing for the future / Connie Marras -- Initial and disease-modifying strategies in Parkinson's disease / Lawrence W. Elmer & Robert A. Hauser -- Prevention and management of levodopa-related motor complications / Cara A. Pecina & Alberto J. Espay -- Management of non-motor symptoms of Parkinson's disease / Mark Stacy -- Management of cognitive and behavioral aspects of Parkinson's disease / Joseph H. Friedman -- Surgical therapy for Parkinson's disease / Nawaz Hack & Michael S. Okun -- Experimental therapeutics for motor symptoms of Parkinson's disease / Susan H. Fox & Lorraine V. Kalia -- Parkinson's disease treatment pipelines / Joseph Jankovic -- Multiple choice questions : answers.
  • Part I: Overview -- Part II: Epidemiology -- Part III: Genetics -- Part IV: Clinical Features of Parkinson's Disease -- Part V: Pathophysiology of Parkinson's Disease -- Part VI: Theories of Pathogenesis -- Part VII: Diagnosis of Parkinson's Disease.
  • History of the discovery of poly (ADP-ribose) -- Discovery of the PARP superfamily and focus on the lesser exhibited but not lesser talented members -- The role of PARPs in DNA Strand Break Repair -- TIPs: Tankyrase Interacting Proteins -- PARP and Carcinogenesis -- Multitasking roles for poly(ADP-ribosyl)ation in aging and longevity -- Overview of PARP Inhibitor Design and Optimization -- Structure Based Design of PARP Inhibitors -- Preclinical chemosensitization by PARP inhibitors -- Classification of PARP inhibitors based on PARP trapping and catalytic inhibition, and rationale for combinations with topoisomerase I inhibitors and alkylating agents -- Radiosensitisation by poly(ADP-ribose) polymerase inhibition -- The vasoactivity of PARP inhibitors -- Synthetic lethality with Homologous Recombination Repair defects -- Targeting tumour hypoxia with PARP Inhibitors: Contextual synthetic lethality -- Other determinants of sensitivity -- Synthetic sickness with molecularly targeted agents against the EGFR pathway -- Disruption of DNA repair by cell cycle and transcriptional CDK inhibition -- Resistance to PARP Inhibitors Mediated by Secondary BRCA1/2 Mutations -- PARP inhibitor resistance -- what is beyond BRCA1 or BRCA2 restoration -- Introduction to PARPi clinical trials and future directions -- Clinical trials investigating PARP inhibitors as single agents -- Clinical trials of PARP inhibitors with chemotherapy -- Combination of PARP inhibitors with clinical radiotherapy -- Biomarkers for PARP Inhibitors.
  • 2013 Cambridge
    Gives graduate students and researchers an introductory overview of partial differential equation analysis of biomedical engineering systems through detailed examples.
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  • Uni history -- Uni: history and look to the future -- Classical patient selection for unicondylar knee arthroplasty -- Indications for unicompartmental knee arthroplasty -- Spacer devices: old and new -- Incidence of partial knee arthroplasty: a growing phenomenon? -- Biological options -- Use of biologics for degenerative joint disease of the knee -- Allografts for the arthritic knee -- Nonarthroplasty treatment options for unicompartmental degenerative joint disease -- Techniques -- Surgical pearls for fixed-bearing medial unicompartmental knee arthroplasty -- Medial unicompartmental knee arthroplasty: fixed-bearing techniques -- Unicompartmental knee arthroplasty: mobile-bearing techniques -- Medial unicompartmental knee replacement: cementless options -- Lateral unicompartmental knee arthroplasty -- Computer-guided partial knee replacement -- Individualized unicompartmental knee arthroplasty -- Patella in medial unicompartmental knee arthroplasty -- Minimally invasive surgery: medial fixed-bearing onlay unicompartmental knee arthroplasty -- Outcomes -- Mobile-bearing uni: long-term outcomes -- Fixed-bearing uni: long-term outcomes -- Patella and hybrid options -- Patellofemoral arthroplasty: indications and outcomes -- Long-term patellofemoral progression -- Hybrid arthroplasty: two-compartment approach -- Modular bicompartmental knee arthroplasty -- Complications -- Failure modes of unicompartmental arthroplasty -- Failed uni -- Painful medial unicompartmental knee arthroplasty -- Putting it all together -- Practical issues in unicompartmental knee arthroplasty: the secrets for success -- Anesthesia, pain management, and early discharge for partial knee arthroplasty -- Deep vein thrombosis prophylaxis following unicompartmental knee arthroplasty -- Multimodal approach to transfusion avoidance and blood loss management in partial knee arthroplasty -- Bilateral unicompartmental knee arthroplasty.
  • Particle toxicology 2007
    An introduction to particle toxicology: from coal mining to nanotechnology / Paul J.A. Borm and Ken Donaldson -- Mineralogy and structure of pathogenic particles / Tim Jones and Kelly Bérubé -- Particle dosimetry: deposition and clearance from the respiratory tract and translocation towards extra-pulmonary sites / Wolfgang G. Kreyling ... [et al.] -- Particulate air pollutants and small airway remodeling / Andrew Churg -- Particle-mediated extracellular oxidative stress in the lung / Frank J. Kelly and Ian S. Mudway -- Particles and cellular oxidative and nitrosative stress / Dale W. Porter, Stephen S. Leonard, and Vincent Castranova -- Interaction of particles with membranes / Barbara Rothen-Rutishauser, Samuel Schurch, and Peter Gehr -- Particle-associated metals and oxidative stress in signaling / James M. Samet and Andrew J. Ghio -- Proinflammatory effects of particles on macrophages and epithelial cells / Vicki Stone ... [et al.] -- Cell-signaling pathways elicited by particulates / Jamie E. Levis and Brooke T. Mossman -- Particle-associated organics and proinflammatory signaling / Francelyne Marano, Sonja Boland, and Armelle Baeza-Squiban -- The asbestos model of interstitial pulmonary fibrosis: TNF-a and TGF-b1 as mediators of asbestos-induced lung fibrogenesis / Deborah E. Sullivan and Arnold R. Brody -- Effects of particles on the immune system / M. Ian Gilmour, Tina Stevens, and Rajiv K. Saxena -- Effects of particles on the cardiovascular system / Nicholas L. Mills ... [et al.] -- Susceptibility to particle effects / Steven R. Kleeberger and Reuben Howden -- Genotoxic effects of particles / Roel P.F. Schins and Tom K. Hei -- Approaches to the toxicological testing of particles / Ken Donaldson ... [et al.] -- Models for testing the pulmonary toxicity of particles: Lund bioassay screening studies in male rats with a new formulation of TIO2 particulates / David B. Warheit, Kenneth L. Reed, and Christie M. Sayes -- Air pollution and human brain pathology: a role for air pollutants in the pathogenesis of Alzheimer's disease / Lilian Calderón-Garcidueñas and William Reed -- Biologically based lung dosimetry and exposure-dose-response models for poorly soluble inhaled particles / Lang Tran and Eileen Kuempel -- Nanoparticles in medicine / Paul J.A. Borm and Detlef Muller-Schülte -- The toxicology of inhaled particles: summing up an emerging conceptual framework / Den Donaldson, Lang Tran, and Paul J.A. Borm.
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  • Edited by Dr. Marc Neff, Passing the General Surgery Oral Board Exam, Second Edition helps candidates prepare for the General Surgery Oral Board Exam in a different way than other review books. In addition to covering concepts frequently addressed on the test, the review also alerts you to 'common curveballs' and 'strikeouts'- the unexpected problems or seemingly benign actions (or inactions) that could result in a missed diagnosis or misdiagnosis, and thus result in failure to pass the exam. Fully updated and expanded to reflect the many changes in standards of care, this unique study guide is the first to expose the potential traps and pitfalls of the exam by providing examples of how the questions may be asked and what not to say in response.
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  • ABOUT THE FRCS -- ANATOMY -- Upper limb -- Lower limb -- Surgical approaches -- SPINE -- Spinal trauma -- Tumours -- Infections -- Stenosis -- Disc prolapse -- Scoliosis (Paediatric and adult) -- Back pain -- Ankylosing spondylitis -- Rheumatoid spine -- Spondylolisthesis -- Cervical spondylosis -- Kyphosis -- PAEDIATRICS -- DDH -- Perthes -- SCFE -- CP -- Neurofibromatosis -- Skeletal dysplasias -- Paediatric trauma -- Club feet -- Metatarsus adductus -- Congenital vertical talus -- BASIC SCIENCES -- Statistics -- Cartilage -- Bone -- Muscles -- Tendons/ligaments -- Meniscus -- Radiation -- Arthritides -- Metals -- Theatre design -- Traction -- Free body diagrams -- Gait cycle -- LOWER LIMB ARTHROPLASTY -- Hip replacement -- Knee replacement -- TRAUMATOLOGY -- Upper limb -- Lower limb -- Scores in trauma -- FOOT AND ANKLE -- Biomechanics -- Arthroscopy -- Arthritis -- Instability -- Hallux rigidus -- Hallux valgus -- Interdigital neuroma -- Neuropatic foot -- Rheumatoid foot -- Tarsal tunnel -- Lesser toe deformities -- Pes planus -- Charcot Marie Tooth -- ORTHOTICS/AMPUTATIONS/REHABILITATION -- Orthotics and braces -- Amputation -- Rehabilitation -- SPORTS -- HANDS -- Rheumatoid hand -- Tendon injuries (flexors/extensors) -- Distal radial fractures -- Scaphoid fractures -- Kienbocks disease -- Trigger fingers -- Dupuytrens disease -- DRUJ and TFCC injuries -- Concepts of tendon transfers -- Carpal instability -- CMCJ thumb arthritis -- Wrist arthritis -- Carpal tunnel syndrome -- De quervain tenosynovitis -- UPPER LIMB -- ACJ arthritis -- Sub acromial impingement -- Cuff tear -- Cuff arthropathy -- Shoulder arthritis -- Shoulder rheumatoid arthritis -- Shoulder ON -- Calcific tendinopathy -- Frozen shoulder -- SLAP -- Shoulder instability -- Elbow OA -- Rheumatoid arthritis -- Instability -- Tendinopathies -- Biceps rupture -- Elbow arthroscopy -- Elbow arthroplasty -- ONCOLOGY -- Basic concepts (classifications, biopsy...) -- Benign tumors (bone, cartilage, others) -- Malignant tumors (bone, cartilage, others) -- PHYSICAL EXAMINATIONS -- Hip -- Knee -- Shoulder -- Spine -- Elbow -- Hand -- Foot and ankle -- Gait cycle -- GEMS -- What you will not find in the books but might be asked in the exam -- UP TO DATE REFERENCES -- Per topics.
  • Pasteurella multocida: Diseases and Pathogenesis / I. W. Wilkie, M. Harper, J. D. Boyce and B. Adler -- Pathogenomics of Pasteurella multocida / J. D. Boyce, T. Seemann, B. Adler and M. Harper -- The Key Surface Components of Pasteurella multocida: Capsule and Lipopolysaccharide / Marina Harper, John D. Boyce and Ben Adler -- Pasteurella multocida and Immune Cells / Katharina F. Kubatzky -- Molecular Biology of Pasteurella multocida Toxin / Joachim H. C. Orth and Klaus Aktories -- Pasteurella multocida Toxin Interaction with Host Cells: Entry and Cellular Effects / Brenda A. Wilson and Mengfei Ho -- Swine Atrophic Rhinitis Caused by Pasteurella multocida Toxin and Bordetella Dermonecrotic Toxin / Yasuhiko Horiguchi -- The Pasteurella multocida Toxin: A New Paradigm for the Link Between Bacterial Infection and Cancer / Alistair Lax.
  • "This book summarizes the state of the art in process analytical technologies applied to various aspects of biopharmaceutical process development and manufacturing. The text summarizes regulatory perspectives, FDA/EMEA guidelines, and new expectations. In addition, it explores new technology, especially in the area of real-time monitoring for end-point control as well as new sensor and analytical technologies. It details established and emerging measurement technologies, including future needs and challenges that require further research. The authors also present successful industrial-scale deployment case studies and strategies from the biopharmaceutical industry and discuss future trends"-- Provided by publisher.
  • This book is a compendium of tips on many different aspects of patch testing based on the recommendations of the International Contact Dermatitis Research Group (ICDRG), which is the reference group for all dermato-allergologists. It is intended to complement the book Patch Testing and Prick Testing: A Practical Guide by J.-M. Lachapelle and H. Maibach, which is an official publication of the ICDRG now in its third edition. Among the wide variety of topics covered are pitfalls, legal aspects, patch testing with ultrasonic bath extracts, the role of patch testing in occupational contact dermatitis and atopic dermatitis, semi-open tests, the implications of a negative test, patch testing validity, selection of extra allergens and patch testing in the tropics. Many illustrations are included and all information is completely up-to-date. This book will be of value to all practicing dermatologists.
  • Patellar Instability Surgery in Clinical Practice analyses in a step by step format, the different reconstruction techniques for the medial patellofemoral ligament (MPFL) reconstruction as well as other techniques less frequently used in the patient with lateral patellofemoral instability. also the treatment of medial patellofemoral instability is also explained. Patellar Instability surgery is a very practical book, aimed at junior and general orthopedic surgeon who require a useful easy reference for these common knee procedures but will also be of great interest to those surgeons who specialized in knee surgery.
  • Patellofemoral disorders are extremely prevalent in athletes and can lead to chronic pain, instability, weakness, and inconsistent or poor athletic performance. These disorders can be difficult to diagnose.Treatment options can vary depending upon several factors, including the sport andthe time during the sports season when the symptoms occur. Treatment also varies depending on the age of the patient and their competition level. The Patellofemoral Joint in the Athlete provides an extensive review of the physical examination, radiographic evaluation, differential diagnoses, and treatment options of common patellofemoral disorders, including patellar chondrosis, pain and instability. The contributors are nationally recognized experts in the patellofemoral joint that treat athletes of all ages and abilities. Appropriate for orthopedic surgeons, sports medicine physicians, rehabilitation physicians and physical therapists, this book is a comprehensive guide to the unique and sport-specific concerns of athletesof all ages and abilitieswith regard to the patellofemoral joint.
  • A comprehensive and thorough selection of contributions from across the world, this book aims to review the current state-of-the-art in assessment and management of the patellofemoral joint. While featuring a wide range of surgical techniques for different pathologies, detailed attention is also devoted to conservative treatment and approaches involving mesenchymal stem cells, autologous chondrocyte implantation, platelet-rich plasma, and pulsed electromagnetic fields. Anatomy, clinical examination, and methods of evaluation are discussed, and individual chapters address important miscellaneous topics, including rehabilitation, complications of surgery, injuries in specific patient populations, and scoring systems. Though patellofemoral joint pathology is a frequent clinical problem, its management remains challenging for the orthopaedic surgeon. Conceived at the ISAKOS Congress held in Toronto in June 2013 as a small booklet, this work quickly turned into a major project involving more than 35 authors worldwide. The editors believe that this book will be of great value to orthopaedic doctors to improve understanding, diagnosis, and treatment of future patients.
  • Pathophysiology of anterior knee pain -- Pathophysiology of lateral patellar dislocation -- Natural history of patellofemoral dislocations -- Clinical presentation of patellofemoral disorders -- Clinical examination of the patellofemoral patient -- Standard X-ray examination: patellofemoral disorders -- Patellar height: which index? -- Stress radiographs in the diagnosis of patellofemoral instability -- Computed tomography and arthro-CT scan in patellofemoral disorders -- MRI analysis of patella instability factors -- MRI of the patellofemoral articular cartilage -- Patellofemoral pain syndrome: the value of pinhole and SPECT scintigraphic imaging and quantitative measurements of bone mineral equivalent density with quantitative computed tomography -- Gait analysis in patients with patellofemoral disorders -- Iatrogenic anterior knee pain with special emphasis on the clinical radiographical, histological, ultrastructural and biochemical aspects after anterior cruciate ligament reconstruction using ipsilateral autografts -- Non-operative treatment of patellofemoral pain: role of physical therapy -- Lateral release of the lateral patellofemoral retinaculum: literature review for select patellofemoral disorders -- Medial side patellofemoral anatomy -- Arthroscopic medial reefing in acute patellar dislocation -- Medial reefing in chronic potential patellar instability -- Medial patellofemoral ligament reconstruction -- MPFL reconstruction: the adductor sling approach -- Importance and radiographic identification of the femoral insertion in medial patellofemoral ligament reconstruction -- MPTL (medial patellotibial ligament) reconstruction -- Distal realignment: medialization of tibial tuberosity: the Elmslie-Trillat technique -- Bony surgery distal realignment surgery -- Trochlear lengthening osteotomy with or without elevation of the lateral trochlear facet -- Proximal open trochleoplasty (grooveplasty) -- Deepening trochoplasty for patellar instability -- Arthroscopic deepening trochleoplasty for patella instability -- The role of limb rotational osteotomy -- Long-term results after autologous chondrocyte implantation in cartilage lesions of the patellofemoral joint -- Novel nano-composite multilayered biomaterial for the treatment of patellofemoral cartilage lesions -- Isolated patellofemoral osteoarthritis: natural history and clinical presentation -- The nonoperative treatment of patellofemoral arthritis -- Current concepts regarding tibial tubercle osteotomy -- Isolated patellofemoral osteoarthritis: prosthetic indications -- Post-operative management of surgeries aimed at correcting patellofemoral instability: results of an international surgeon survey -- Errors and complications in patellofemoral surgery -- Trochleoplasty for symptomatic trochlear dysplasia in the skeletally immature patient with review of fetal anatomy -- Patellofemoral disorders in the skeletally immature patients.
  • SECTION I: BACKGROUND AND ANATOMY -- Historical perspective and importance of PFO -- Embryology, Neonatal Circulation and Anatomy of PFO -- Anatomical variations of Patent Foramen Ovale -- Aging and Patent Foramen Ovale -- SECTION II: METHODS AND TECHNIQUES FOR DETECTION AND CHARACTERIZATION OF PFO -- Echocardiographic detection and transcranial Doppler quantification of right-to-left shunting. -- ICE: intra-procedural evaluation and guidance during closure of PFO -- A Comparison of Methods to Detect and Quantitative PFO: TCD, TTE, ICE and TEE -- Angiographic evaluation for PFO and Pulmonary AVMs -- SECTION III: PFO AND CLINICAL SYNDROMES -- An Overview of Clinical Syndromes (Keeping The Heart In Mind) -- The Association of Patent Foramen Ovale and Migraine Headache -- Current Patient Management Issues, Clinical Trial Design Challenges, and the Pathway Forward -- Patent foramen ovale and divers -- Orthodeoxia and Platypnea -- Obstructive Sleep Apnea and Patent Foramen Ovale -- PFO and Various Types of Surgery -- When a PFO is Discovered Incidentally -- SECTION IV: CLOSURE METHODS -- The GORE Septal Occluder -- The novel PFO specific closure devices: Why did they fail? -- Optimal device for children and closure indications in pediatric population -- Occlutech, PFM, Lifetech, and other new devices. What?s on the horizon? -- Complications of PFO Closure -- SECTION V: STATISTICAL METHODS, TRIALS AND TRIBULATIONS -- Device Closure of Patent Foramen Ovale or Medical Therapy for Cryptogenic Stroke: The CLOSURE I Trial -- The Gore REDUCE Clinical Study -- The PC Trial: An Effective Treatment Not Demonstrating Effective Power -- From FDAs point of view: What is needed to move PFO closure for stroke prevention forward? -- The Medical Device Manufacturer?s Perspective ? W.L. Gore & Associates, Inc -- PFO-Patient?s Perspective -- Clinical Trials to Assess the Relationship between Patent Foramen Ovale and Migraine Headaches -- Do We Need More PFO Trials: Hypercoaguable Syndromes, Obstructive Sleep Apnea, and Arrhythmias -- SECTION VI: DIFFICULTIES/OBSTACLES IN STARTING PFO CLOSURE PRACTICE -- Obstacles in Starting a PFO Closure Program. How I Did It -- Developing a successful integrated PFO closure program.
  • The Path from Biomarker Discovery to Regulatory Qualification is a unique guide that focuses on biomarker qualification, its history and current regulatory settings in both the US and abroad. This multi-contributed book provides a detailed look at the next step to developing biomarkers for clinical use and covers overall concepts, challenges, strategies and solutions based on the experiences of regulatory authorities and scientists. Members of the regulatory, pharmaceutical and biomarker development communities will benefit the most from using this book-it is a complete and practical guide to biomarker qualification, providing valuable insight to an ever-evolving and important area of regulatory science. Contains a collection of experiences of different groups taking different types of biomarkers to different levels of qualification and provides insightful case studies of an important area of regulatory science Focuses on practical advice, concepts, strategies and overall outcomes to support those working toward biomarker qualification for clinical use Offers a valuable resource for members of the regulatory, pharmaceutical and biomarker development communities.
  • The Impact of Foreign DNA Integration on Tumor Biology and Evolution via Epigenetic Alterations / Walter Doerfler -- The Role of DNMT3B Mutations in the Pathogenesis of ICF Syndrome / Sole Gatto, Maurizio D'Esposito and Maria R. Matarazzo -- Dysfunction of the Methyl-CpG-Binding Protein MeCP2 in Rett Syndrome / Gaston Calfa, Alan K. Percy and Lucas Pozzo-Miller -- Epigenetic Alterations in Glioblastoma Multiforme / John K. Wiencke -- Aberrant Epigenetic Regulation in Breast Cancer / Amanda Ewart Toland -- The Impact of Epigenetic Alterations on Diagnosis, Prediction, and Therapy of Prostate Cancer / Christian Arsov, Wolfgang Goering and Wolfgang A. Schulz -- Epigenetic Reprogramming in Lung Carcinomas / András Kádár and Tibor A. Rauch -- Epigenetic Changes in Virus-Associated Neoplasms / Hans Helmut Niller, Ferenc Banati, Eva Ay and Janos Minarovits -- Genetic and Epigenetic Determinants of Aggression / Barbara Klausz, József Haller, Áron Tulogdi and Dóra Zelena -- Co-Regulation and Epigenetic Dysregulation in Schizophrenia and Bipolar Disorder / Dóra Zelena -- Disruption of Epigenetic Mechanisms in Autoimmune Syndromes / Lorenzo de la Rica and Esteban Ballestar -- Imprinting Disorders / Thomas Eggermann -- Epigenetics and Atherosclerosis / Einari Aavik, Mikko P. Turunen and Seppo Ylä-Herttuala -- Microbe-Induced Epigenetic Alterations / Hans Helmut Niller, Ferenc Banati, Eva Ay and Janos Minarovits.
  • Bacterial toxins as immunomodulators / David S. Donaldson and Neil A. Williams -- Innate immune evasion by staphylococci / Karin Ellen Veldkamp and Jos A.G. van Strijp -- Bacterial complement escape / Ilse Jongerius, Sanjay Ram, and Suzan Rooijakkers -- Modulation of innate immune signalling pathways by viral proteins / Orla Mulhern, Barry Harrington, and Andrew G. Bowie -- Viral TNF inhibitors as potential therapeutics / Masmudur M. Rahman, Alexandra R. Lucas, and Grant McFadden -- Lipoxins as an immune-escape mechanism / Fabiana S. Machado and Julio Aliberti -- Immunomodulatory activity and therapeutic potential of the filarial nematode secreted product, ES62 / William Harnett and Margaret M. Harnett -- Helminth-derived immunomodulatory molecules / Poom Adisakwattana ... [et al.] -- Fungal-derived immune modulating molecules / Tania C. Sorrell and Sharon C.A. Chen -- The immunosuppresive tick salivary protein, Salp15 / Ignacio J. Juncadella and Juan Anguita -- The serpin saga; development of a new class of virus derived anti-inflammatory protein immunotherapeutics / Alexandra Lucas ... [et al.] -- Helminthic therapy : using worms to treat immune-mediated disease / David E. Elliott and Joel V. Weinstock -- Chemokine binding proteins encoded by pathogens / Antonio Alcami and Margarida Saraiva.
  • Atopic dermatitis and the hygiene hypothesis revisited / Flohr, C., Yeo, L. -- Loss-of-function mutations within the filaggrin gene predispose to atopic dermatitis / Kawasaki, H. ... [et al.] -- Fc epsilon R1-toll-like receptor interaction in atopic dermatitis / Novak, N., Bieber, T. -- The antimicrobial skin barrier in patients with atopic dermatitis / Schittek, B. -- Defective sweating responses in atopic dermatitis / Shiohara, T., Doi, T., Hayakawa, J. -- The role of cytokines/chemokines in the pathogenesis of atopic dermatitis / Yamanaka, K., Mizutani, H. -- Contribution of interleukin 18 to the development of infection-associated atopic dermatitis / Tsutsui, H., Mizutani, H., Nakanishi, K. -- Innate immunity in atopic dermatitis / Mrabet-Dahbi, S., Maurer, M. -- The role of regulatory T cells in atopic dermatitis / Agrawal, R., Wisniewski, J., Woodfolk, J.A. -- Increased susceptibility to cutaneous viral infections in atopic dermatitis : the roles of regulatory T cells and innate immune defects / Shiohara, T. ... [et al.] -- Biomarkers for itch and disease severity in atopic dermatitis / Lee, C.-H., Yu, H.-S. -- Practical issues on interpretation of scoring atopic dermatitis : SCORAD index, objective SCORAD, patient-oriented SCORAD and three-item severity score / Oranje, A.P. -- Systemic therapy of atopic dermatitis in children and adults / Simon, D.
  • This book, written by experts from across the world, provides comprehensive coverage of acne and rosacea, focusing in particular on pathogenesis and treatment but also considering clinical aspects, prognostic factors, and impacts on quality of life. Both standard knowledge and important, clinically relevant insights that have emerged over the past decade are presented with the goal of assisting the reader in understanding these diseases and improving treatment outcome. It is explained how high-level research has recently given rise to a variety of new concepts in etiology and treatment, and emerging trends are also discussed. The book is in a reader-friendly format that highlights core messages with a very practical and clinical focus. Pathogenesis and Treatment of Acne and Rosacea will be an indispensable reference for all physicians who care for patients with acne or rosacea and for scientists working in the field.
  • Mycobacterium tuberculosis is one of the most notorious pathogens on earth, causing the death of approximately 1.5 million people annually. A major problem in the fight against tuberculosis is the emergence of strains that have acquired resistance to all available antibiotics. One key to the success of M. tuberculosis as a pathogen is its ability to circumvent host immune responses at different levels. This is not only a result of the special makeup of M. tuberculosis in terms of genetic diversity and DNA metabolism and its possession of specialized secretion systems, but also of its ability to hijack the host's innate immune defence mechanisms. In this volume, researchers from different disciplines provide a topical overview of the diverse mechanisms that contribute to the virulence of M. tuberculosis, ranging from their genetic, metabolic and molecular makeup, as well as the complex strategies these bacteria utilize to escape immune destruction within infected hosts.
  • This book explores the many mechanisms by which the most prevalent Spirochetal pathogens persist in a healthy immune-competent host. Among them are the direct and indirect suppression of host immune signals, phase and antigenic variation, escaping recognition by host complement proteins, and seclusion into immune privileged sites.
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  • Pathogenic yeasts 2010
  • Pathologic myopia 2014
    Pathological Myopia is a major cause of severe vision loss worldwide. The mechanisms for vision loss include cataract, glaucoma, retinal detachment, and above all, degeneration of the macula within the posterior staphyloma. Pathological Myopia is one of the only current books to specifically address this disease and discusses recent developments in imaging technologies and various approaches to treatments, such as laser photocoagulation, photodynamic therapy, pharmaco-therapeutic injections in the vitreous, and surgery. Complete with high-quality color images, this book is written and edited by leaders in the field and is geared towards ophthalmologists, including residents and fellows in training, glaucoma and cataract specialists, and vitreoretinal macula experts.
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    "While iconic popular images celebrated family life during the 1950s and 1960s, American families were simultaneously regarded as potentially menacing sources of social disruption. The history of family therapy makes the complicated power of the family at midcentury vividly apparent. Clinicians developed a new approach to psychotherapy that claimed to locate the cause and treatment of mental illness in observable patterns of family interaction and communication rather than in individual psyches. Drawing on cybernetics, systems theory, and the social and behavioral sciences, they ambitiously aimed to cure schizophrenia and stop juvenile delinquency. With particular sensitivity to the importance of scientific observation and visual technologies such as one-way mirrors and training films in shaping the young field, The Pathological Family examines how family therapy developed against the intellectual and cultural landscape of postwar America." -- [Publisher-supplied data]
  • Calcium ions represent Mother Nature's "ion-of-choice" for regulating fundamental physiological functions, as they initiate a new life at the time of fertilization and guide subsequent developmental and physiological functions of the human body. Calcium channels, which act as gated pathways for the movement of calcium ions across the membranes, play a central part in the initiation of calcium signals, and defects in calcium channel function have been found to result in a plethora of human diseases, referred to as the calcium channelopathies. Pathologies of Calcium Channels brings together leading international experts to discuss our current understanding of human diseases associated with the various calcium channels, from their molecular basis to potential future therapeutic targeting of calcium channels.
  • Ch. 1. Enteroviruses -- Ch. 2. Rhinoviruses -- Ch. 3. Influenza viruses -- Ch. 4. Parainfluenza viruses -- Ch. 5. Respiratory syncytial virus (RSV) -- Ch. 6. Herpesviruses: general principles -- Ch. 7. Herpes simplex virus (HSV) types 1 and 2 -- Ch. 8. Cytomegalovirus -- Ch. 9. Epstein-Barr virus (EBV) -- Ch. 10. Varicella-Zoster virus (VZV) -- Ch. 11. Herpesvirus type 6 (HHV-6) -- Ch. 12. Kaposi sarcoma-associated herpesvirus (KSHV, HHV-8) -- Ch. 13. Herpesvirus simiae virus (Herpes B) -- Ch. 14. Adenoviruses -- Ch. 15. Retroviruses: general principles -- Ch. 16. Human immunodeficiency viruses -- Ch. 17. Human T cell leukemia/lymphoma viruses (HTLV-1 and -2) -- Ch. 18. Hepatitis viruses -- Ch. 19. Hemorrhagic fever viruses -- Ch. 20. Hantavirus pulmonary syndrome (HPS) -- Ch. 21. Papillomaviruses -- Ch. 22. Papovaviruses -- Ch. 23. Parvoviruses -- Ch. 24. Neurotropic arthropod-transmitted viruses -- Ch. 25. Rabieviruses -- Ch. 26. Poxviruses -- Ch. 27. Mumps -- Ch. 28. Rubellavirus -- Ch. 29. Rubeola (measles) -- Ch. 30. Transmissible spongiform encephalopathy -- Ch. 31. Lymphocytic choriomeningitis virus (LCMV) -- Ch. 32. Enteric viral disease.
  • This is the first comprehensive book about surgery on and around the vertebral artery all along its cervical and intracranial course. This vessel has been considered for long as out of surgical reach leaving many different pathologies not or incompletely treated. The surgical exposure and control of the vertebral artery not only permit to treat lesions of the vertebral artery wall or developed in contact to it but also to improve the access to the intervertebral foramen (tumors, osteophytes), to the anterior aspect of the spinal cord (tumors, spondylotic spurs), to the foramen magnum and to the jugular foramen. This book written by leading experts includes all aspects of vertebral artery surgery from anatomy to imaging, surgical techniques and pathologies; it is illustrated by many figures especially operative views and schematic drawings so that the beginner as well as the experienced surgeon find useful information. One of the editors of this book (B. GEORGE) was recently awarded the Olivecrona award for his work on the surgery of the vertebral artery.
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  • The third edition of Pathology of Asbestos-Associated Diseases builds on the success of the previous editions by fully updating knowledge on diagnostic and epidemiologic aspects and presenting important new insights derived from new epidemiologic studies and animal studies. Background information is first provided on the mineralogy of asbestos, occupational and environmental exposure, and asbestos bodies. The various diseases associated with asbestos exposure are then considered in turn, with detailed description and illustration of pathologic features as well as extensive discussion of etiology, epidemiology, differential diagnosis, treatment, and prognosis. Further chapters are devoted to cytopathology, experimental models of disease, and analysis of tissue mineral fiber content. In addition, the medicolegal issues relating to asbestos-associated diseases are analyzed from the point of view of both the plaintiff and the defendant. This book will be an essential reference for pathologists and an invaluable source of information for pulmonologists, radiologists, and occupational medical practitioners.
  • Part I: Introductory Chapters -- Chapter 1. Gross Prosection of Melanocytic Lesions -- Chapter 2. Histopathologic Staging and Reporting of Melanocytic Lesions -- Chapter 3. Clinicopathologic Correlation in Melanocytic Lesions -- Chapter 4. Anathema or Useful? Application of Immunohistochemistry to the Diagnosis of Melanocytic Lesions -- Chapter 5. Applications of Additional Techniques to Melanocytic Pathology -- Part 2: Diagnostic Challenges -- Chapter 6. Spitz Nevus versus Spitzoid Melanoma -- Chapter 7. Halo Nevus versus Melanoma with Regression -- Chapter 8. Nevoid Malignant Melanoma versus Melanocytic Nevus -- Chapter 9. Dysplastic Nevi versus Melanoma -- Chapter 10. Blue Nevus versus Pigmented Epithelioid Melanocytoma -- Chapter 11. Recurrent Melanocytic Nevus versus Melanoma -- Chapter 12. Neurothekeoma versus Melanoma -- Chapter 13. Melanoma in situ versus Paget?s Disease -- Chapter 14. Desmoplastic Nevus versus Desmoplastic Melanoma -- Chapter 15. Cutaneous Metastatic Melanoma versus Primary Cutaneous Melanoma -- Chapter 16. Acral Nevus versus Acral Melanoma -- Chapter 17. Capsular (Nodal) Nevus versus Metastatic Melanoma -- Index.
  • Pathology of Infectious Diseases, by Gary W. Procop, MD, packs all of today's most essential information on infectious disease pathology into a compact, high-yield format! Well-organized and segmented by type of infectious organism, the book's pragmatic approach complemented by abundant full-color, high-quality photomicrographs and clinical photos, and at-a-glance tables makes it easy to access the information you need to quickly and accurately detect and identify pathogenic organisms. Chapters on immunohistochemical and molecular techniques as well as artifacts and pitfalls guide you to accurate detection and identifications.
  • Epidemiology of Mesothelioma -- Molecular Biology -- Serosal Anatomy and Anatomic Distribution of Mesothelioma -- Clinical Aspects of Mesothelioma -- Management of Malignant Serosal Effusions -- Pathologic Diagnosis and Classification of Mesothelioma -- Macroscopic Features of Mesotheliomas -- Classification and Histologic Features of Mesotheliomas -- Differential Diagnosis: Mesothelial Proliferations -- Differential Diagnosis: Other Mesothelial Lesions -- Differential Diagnosis: Nonmesothelial Lesions -- Differential Diagnosis: Nonmesothelial Tumors of the Serosal Cavity: Sarcomas -- Differential Diagnosis: Other Nonmesothelial Tumors.
  • Highly acclaimed and considered the leading reference in the field, Pathology of Melanocytic Nevi and Melanoma has once again been fully revised, updated, and expanded to reflect the most recent advances and techniques in the field of melanoma pathology. New chapters on mucosal melanoma, ocular melanoma, and pigmented lesions of the nail apparatus have been included in this new edition. The successful focus and format of the previous editions have been preserved. Each lesion and diagnosis is clearly illustrated withthe aid of a wealth of digitally enhanced full-color photomicrographs. A concise description of the clinical features, histopathology, differential diagnosis, and outstanding characteristics of each lesion provides readers with a quick yet comprehensive overview of each topic covered. Pathology of Melanocytic Nevi and Melanoma is the essential reference for every practicing dermatopathologist, pathologist, dermatologist, and cancer research scientist today.
  • Pediatric gastrointestinal and liver biopsies account for a significant portion of the specimens examined by a pathology laboratory. The increasingly widespread use of endoscopic procedures in children, the improved sophistication of medical imaging techniques, and the exciting expansion of knowledge in genetic medicine have all led to new advances and opportunities in pediatric hepatogastroenterology and pathology. Pathology of Pediatric Gastrointestinal and Liver Disease provides the pediatric pathologist, the GI or general pathologist, and the pediatric gastroenterologist with the most complete and current reference on the subject. With an emphasis on clinical-pathological correlation, the book includes in-depth discussions on disorders and issues that are frequently encountered but for which up-to-date information is often not readily available, as well as infrequent disorders unique or specific to children that are not covered in standard texts. Significant revision has been undertaken since the first edition, with the inclusion of many new illustrations and electron micrographs. Among the topics covered are malabsorption and motility disorders, immunodeficiencies, including HIV, developmental malformations, food allergies, cystic diseases of the liver, hepatic tumors, and esophageal and pancreatic disorders. The book is richly illustrated, with many figures in color, and the high-quality endoscopic and radiographic images permit ready correlation with the pathologic principles under discussion.
  • Immunology of organ transplantation -- Current concepts of immunosuppression and side effects -- Clinical aspects of infections -- Clinical evaluation of alloantibiodies in solid organ transplantation -- Frontiers in organ transplantation -- Kidney -- Lung -- Liver -- Heart -- Small intestine -- Pancreas -- Vascularized composite allotransplantation.
  • Covering a comprehensive range of common, rare, benign and malignant lesions, Pathology of the Female Reproductive Tract, 3rd Edition, authored by an international panel of subspecialty experts, brings you the latest scientific and diagnostic information for diseases of the female reproductive tract. From basic concepts of pathophysiology and diagnostic criteria to clinical correlation, this updated medical reference book delivers an integrated and practical approach to diagnosis and management of women with reproductive tract disorders. Quickly and easily access key information with user-friendly bullet points, diagnostic flowcharts, decision-making algorithms, summary tables, and take-home messages, as well as a "Road Map" at the beginning of each chapter for effortless navigation.Avoid diagnostic errors with the help of practical, expert advice on common pitfalls in differential diagnosis. Browse the complete contents from any location with online access at Expert Consult.
  • Pathology of the Human Placenta remains the most comprehensive and authoritative text in the field. It provides extensive information on the normal placenta, encompassing physiology, metabolism, and endocrinology, and covers placental diseases in great detail. The conditions discussed include shape aberrations, villous alterations and maldevelopment, erythroblastosis fetalis and hydrops fetalis, transplacental hemorrhage, fetal storage disorders, diverse maternal diseases, and infectious diseases. Further chapters are devoted to abortions, molar pregnancies, trophoblastic neoplasms, benign tumors, and multiple pregnancies. Legal considerations are carefully explored, and this new edition also includes a completely new chapter on artificial reproductive technology. In other respects, too, the book has been extensively revised and expanded, with wide-ranging updates that reflect the most recent progress in the field. Some 800 illustrations are included, many of them in color. The detailed index has been further improved and tables updated. Pathology of the Human Placenta will be of enormous value to pathologists and obstetrician-gynecologists alike.
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    With an emphasis on practical diagnostic problem solving, Pathology of the Lungs 3e provides the pulmonary pathologist and the general surgical pathologist with an accessible, comprehensive guide to the recognition and interpretation of common and rare neoplastic and non-neoplastic lung conditions. The text is written by two authors and covers all topics in a consistent manner without the redundancies or lapses that are common in multi-authored texts. The text is lavishly illustrated with the highest quality illustrations which accurately depict the histologic, immunohistochemical and cytologic findings under consideration and it is supplemented throughout with practical tips and advice from two internationally respected experts. The user-friendly design and format allows rapid access to essential information and the incorporation throughout of relevant clinical and radiographic information makes it a complete diagnostic resource inside the reporting room. Approximately 1,000 high quality full color illustrations. Provides the user with a complete visual guide to each specimen and assists in the recognition and diagnosis of any slide looked at under the microscope. Comprehensive coverage of both common and rare lung diseases and disorders. One stop consultation resource for the reporting room or study, no need to go further to get questions answered. Clinical background and ancillary radiographs incorporated throughout. Provides the user with all of the necessary diagnostic tools to make a complete and accurate pathologic report. Practical advice and tips from two of the world's recognized experts. Provides the trainee and general surgical pathologist with time saving diagnostic clues when dealing with difficult specimens. Consistent and uniform approach incorporated for each disease and disorder (Etiology, pathogenesis, clinical features, pathologic features, differential diagnosis) User-friendly format enables quick and easy navigation to the key information required.
  • Non-neoplastic Diseases of the Maxillofacial Bones -- Cysts -- Odontogenic Tumours -- Fibro-Osseous Lesions -- Giant Cell Lesions -- Bone forming Lesions of the Maxillofacial Bones -- Cartilaginous Lesions of the Maxillofacial Bones -- Other Diseases that involve Bone -- Diseases of the Temporomandibular Joint.
  • As the second volume in the Essentials of Diagnostic Gynecological Pathology series sponsored by the British Association of Gynecological Pathologists, Pathology of the Ovary, Fallopian Tube and Peritoneum is one of the very few dealing wholly with this subject. Pathology of the Ovary, Fallopian Tube and Peritoneum introduces the topic with a discussion of the anatomy, development, histology and normal function of the ovary, followed by chapters on non-neoplastic disorders of the ovary; surgery and medical management of ovarian cancer; and the use of imaging, frozen sections and cytology in ovarian pathology. The book then goes on to describe specific disorders of the ovary, fallopian tube and peritoneum in detail, and finishes with a chapter on specimen cut-up. Pathology of the Ovary, Fallopian Tube and Peritoneum has been written to be useful diagnostically to general as well as specialist gynecological histopathologists and pathologists in training. Gynecologists, oncologists, genitourinary physicians and cancer nurse specialists will find expert insights here that will help in treatment and counselling of their patients.
  • Pathology of the Pancreas: A Practical Approach covers all the diagnostic entities in adult pancreatic pathology, providing extensive illustrations and tables to assist the pathologist at the time of diagnostic reporting of histological and cytological specimens. Potential pitfalls and mimics in pancreatic pathology are highlighted and illustrated, and guidance is provided regarding how to recognize and avoid them. Pathology of the Pancreas: A Practical Approach enables the pathologist to recognize the various pathological entities and provide the key information in their pathology reports, which is necessary for the individual patient's further management. It is based on the most recent diagnostic algorithms, international consensus guidelines, and systems for disease classification, staging and grading. Clinical information is also included, where it is important for the multidisciplinary team management discussion. Pathology of the Pancreas: A Practical Approach is a bench book for everyday use beside the microscope and provides the diagnostic pathologist with a comprehensive, well-illustrated and extensively cross-referenced approach to pancreatic pathology.
  • Appendix 1: Placental weight -- Appendix 2: Medicolegal aspects of placental pathology. Pathology of the placenta: an introduction and overview -- The development and structure of the placenta -- Physiology of the placenta -- Abnormalities of placentation and of placental development -- Macroscopoic abnormalities of the placenta -- Histological abnormalities of the placenta -- The placenta in pregnancies of abnormal duration -- The placenta in maternal disorders -- The placenta in abnormalities and disorders of the fetus -- The placenta in miscarriage -- Infections and inflammatory lesions of the placenta -- The placenta in multiple pregnancy -- Immunopatholgoy of the placenta -- Non-trophoblastic tumours of the placenta -- Gestational trophoblastic disease -- Pathology of the umbilical cord -- Pathology of the membranes -- Correlation of ultrasonic and pathological findings.
  • Development and Anatomy: Disorders of Development -- Vulvovaginal Infections -- Noninfectious Dermatoses of the Vulva -- Cysts, Non neoplastic Glandular Lesions, and Glandular Neoplasms of the Vulva and Vagina -- Melanoctyic Lesions of the Vulva and Vagina -- Precursors of Vulvovaginal Squamous Cell Carcinoma -- Squamous Cell Carcinoma and Basal Cell Carcinoma of the Vulva and Squamous Cell Carcinoma of the Vagina -- Vulvovaginal Mesenchymal Lesions -- Skin Adnexal Tumors.
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  • A two-color page layout, portable size, and a list of the "Top 100 Secrets" in pathology help students and residents to better meet the challenges they face today. They will find all of the features they rely on the Secret Series' for, a question-and-answer format, lists, mnemonics, and tables and an informal tone that make reference fast and easy. No matter what questions arise in practice or while preparing for boards, this 3rd Edition has the answers, in print and online. Uses bulleted lists, tables, short answers, and a highly detailed index to expedite reference. Features 20 new figures, pearls, tips, memory aids, and "secrets" from the experts. Covers all of today's most common procedures and techniques. Includes a list of the "Top 100 Secrets" to keep in mind during a rotation or residency. Features a compact, trim size (5 1/4" x 8 1/2") for enhanced portability. Makes information easier to find with a two-color page layout and "Key Points" boxes. Identifies useful websites to make it easy to find additional information on a specific topic and provides live links in the online version. Self Assessment exercises and matching Q & A for every chapter online with Student Consult to prepare for exams and focus your study on particular areas that you need the most.
  • Pathology the big picture 2008
    Cellular pathology -- Inflammation and repair -- Pathology of the immune system -- Neoplasia -- Environmental and nutritional pathology -- Genetic disorders -- Pediatric pathology -- Hemodynamics -- Vascular pathology -- Cardiac pathology -- Neuropathology -- Hematopathology -- Pulmonary pathology -- Gastrointestinal pathology -- Pathology of the liver, gallbladder, and pancreas -- Pathology of the kidney and bladder -- Pathology of the male and female reproductive tract and breast -- Endocrine pathology -- Pathology of the bones and joints -- Dermatopathology -- Practice examination answers.
  • The criminalistics of controlled substances / Joseph P. Bono -- Overview of pathology of drug abuse : scene of death and the autopsy / Charles V. Wetli -- Heart disease / Renu Virmani, Allen P. Burke, Andrew Farb -- Vascular effects of substance abuse / Frank D. Kolodgie, Allen P. Burke, Jagat Narula, Florabel G. Mullick, Renu Virmani -- Myocardial alterations in drug abusers / Steven B. Karch -- Valvular heart disease / Michael D. Bell -- Lung disease / Michael D. Bell -- Disorders of the central nervous system / Michael D. Bell -- Toxicogenetics in drug abuse : pharmacogenomics for toxicology / Robert M. White, Steven H.Y. Wong -- Toxicogenetics in drug abuse : heritable channelopathies and myopathies / Kathryn A. Glatter, Jonica Calkins, Sanjay J. Ayirookuzhi.
  • Disease and the genome : genetic, developmental and neoplastic disease -- Cell injury, death and aging and the body's response -- Environmental injury -- Clinical practice : anatomic pathology -- Clinical practice : molecular pathology -- Clinical practice : laboratory medicine and patient care -- The vascular system -- Pulmonary pathology -- Pathology of the gastrointestinal tract -- Pathology of the liver, gallbladder and extrahepatic biliary tract -- Pathology of the pancreas -- Pathology of medical renal disease -- Urologic pathology of the lower urinary tract and male gu system -- Hematopathology -- Basic principles of clinical endocrinology -- Breast pathology -- The female reproductive tract -- Soft tissue and bone pathology -- Neuromuscular pathology -- Pathology of the skin -- Pathology of the nervous system.
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  • This book, now in its third edition, aims to promote a deeper understanding of the scientific and clinical basis of nuclear medicine and the new directions in medical imaging, which will lead to better utilization of nuclear medicine techniques in patient management and to further modifications and innovations in the field. The new edition has been revised and updated to reflect recent changes and to ensure that the contents are in line with likely future directions. The book starts by providing essential basic information on general pathophysiology, cell structure, and cell biology as well as the mechanisms of radiopharmaceutical localization in different tissues and cells. The clinical applications of nuclear medicine are then presented in a series of chapters covering every major organ system. These chapters relate the basic relevant knowledge of anatomy, physiology, and pathology to the clinical utilization of various scintigraphic modalities. The therapeutic applications of nuclear medicine, including recent advances, are discussed in a separate chapter. The final chapter is devoted to the biologic effects of ionizing radiations, including radiation from medical procedures. A glossary at the end of the book has been expanded with clear explanations of certain terms and uncommon disease conditions that will help students and trainees in understanding pertinent concepts. It is hoped that this book will continue to help nuclear medicine practitioners, trainees, students, and researchers, as well as professionals in various other medical fields.
  • Pathophysiology cases 2010
    Genetic Disease -- Disorders of the Immune System -- Infectious Diseases -- Neoplasia -- Blood Disorders -- Nervous System Disorders -- Diseases of the Skin -- Pulmonary Disease -- Cardiovascular Disorders: Heart Disease -- Cardiovascular Disorders: Vascular Disease -- Disorders of the Adrenal Medulla -- Gastrointestinal Disease -- Liver Disease -- Disorders of the Exocrine Pancreas -- Renal Disease -- Disorders of the Parathyroids & Calcium & Phosphorus Metabolism -- Disorders of the Endocrine Pancreas -- Disorders of the Hypothalamus & Pituitary Gland -- Thyroid Disease -- Disorders of the Adrenal Cortex -- Disorders of the Female Reproductive Tract -- Disorders of the Male Reproductive Tract -- Inflammatory Rheumatic Diseases.
  • A concise full color review of the mechanisms of blood diseases and disorders based on a Harvard Medical School hematology course Hematological Pathophysiology is a well illustrated easy to absorb introduction to the physiological principles underlying the regulation and function of blood cells and hemostasis as well as the pathophysiologic mechanisms responsible for the development of blood disorders Featuring a strong emphasis on key principles the book covers diagnosis and management primarily within a framework of pathogenesis Authored by world renowned clinician educators at Harvard Medical School Hematological Pathophysiology features content and organization based on a hematology course offered to second year students at that school The book is logically divided into four sections Anemias and Disorders of the Red Blood Cell Disorders of Hemostasis and Thrombosis Disorders of Leukocytes and Transfusion Medicine it opens with an important overview of blood and hematopoietic tissues Features Succinct to the point coverage that reflects current medical education More than 200 full color photographs and renderings of disease mechanisms and blood diseases Each chapter includes learning objectives and self assessment questions Numerous tables and diagrams encapsulate important information Incorporates the feedback of 180 Harvard medical students who reviewed the first draft so you know youre studying the most relevant material possible Provided by publisher.
  • Pathophysiology of disease Latest edition, 2014 (7th ed.)
    6th ed., 2010 AccessMedicine
  • 1 Anatomy of headache -- 2 Animal models of migraine -- 3 Animal models of other primary headaches -- 4 Genetics of headache -- 5 Human models of primary headaches -- 6 Imaging of migraine -- 7 Imaging of other primary headaches -- 8 Neurophysiology of migraine -- 9 Neurophysiology of other primary headaches -- 10 Biochemistry of primary headaches -- 11 Pathophysiology of migraine: current status and future directions -- 12 Pathophysiology of TTH: current status and future directions -- 13 Pathophysiology of cluster headache: current status and future directions -- 14 Pathophysiology of MOH: current status and future directions.
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    Basic cardiac structure and function / Vivek Iyer, Elazer R. Edelman, and Leonard S. Lilly -- The cardiac cycle: mechanisms of heart sounds and murmurs / Nicole Martin and Leonard S. Lilly -- Diagnostic imaging and catheterization / Nicole Martin and Patricia Challender Come -- The electrocardiogram / Lilit Garibyan and Leonard S. Lilly -- Atherosclerosis / James L. Young and Peter Libby -- Ischemic heart disease / Haley Naik, Marc S. Sabatine, and Leonard S. Lilly -- Acute coronary syndromes / Haley Naik, Marc S. Sabatine, and Leonard S. Lilly -- Valvular heart disease / Mia M. Edwards, Patrick T. O'Gara, and Leonard S. Lilly -- Heart failure / Ravi Vikram Shah and Michael A. Fifer -- The cardiomyopathies / Marc N. Wein, G. William Dec, and Leonard S. Lilly -- Mechanisms of cardiac arrhythmias / Hillary K. Rolls ... [et al.] -- Clinical aspects of cardiac arrhythmias / Hillary K. Rolls, William G. Stevenson, and Leonard S. Lilly -- Hypertension / Payman Zamani, Gordon H. Williams, and Leonard S. Lilly -- Diseases of the pericardium / Yanerys Ramos and Leonard S. Lilly -- Diseases of the peripheral vasculature / Arash Mostaghimi and Mark A. Creager -- Congenital heart disease / Vijay G. Sankaran and David W. Brown -- Cardiovascular drugs / Martin W. Schoen ... [et al.].
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    Basic cardiac structure and function / Ken Young Lin ... [et al.] -- The cardiac cycle : mechanisms of heart sounds and murmurs / Henry Jung and Leonard S. Lilly -- Cardiac imaging and catheterization / Henry Jung, Ken Young Lin, and Patricia Challender Come -- The electrocardiogram / Stephen R. Pomedli and Leonard S. Lilly -- Atherosclerosis / Jordan B. Strom and Peter Libby -- Ischemic heart disease / June-Wha Rhee, Marc S. Sabatine, and Leonard S. Lilly -- Acute coronary syndromes / June-Wha Rhee, Marc S. Sabatine, and Leonard S. Lilly -- Valvular heart disease / Christopher A. Miller, Patrick T. O'Gara, and Leonard S. Lilly -- Heart failure / Neal Anjan Chatterjee and Michael A. Fifer -- The cardiomyopathies / Christopher T. Lee, G. William Dec, and Leonard S. Lilly -- Mechanisms of cardiac arrhythmias / Ranliang Hu ... [et al.] -- Clinical aspects of cardiac arrhythmias / Ranliang Hu, William G. Stevenson, and Leonard S. Lilly -- Hypertension / Christopher T. Lee, Gordon H. Williams, and Leonard S. Lilly -- Diseases of the pericardium / Yin Ren and Leonard S. Lilly -- Diseases of the peripheral vasculature / Fan Liang and Mark A. Creager -- Congenital heart disease / David D. Berg and David W. Brown -- Cardiovascular drugs / Cyrus K. Yamin ... [et al.].
  • v. 2, 2004 Karger
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    1. Pulmonary, ob/gyn, ent, hem/onc -- 2. GI, neurology, rheumatology, endocrinology -- 3. CVS, dermatology, GU, general surgery.
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    I. Pulmonary, ob/gyn, ENT, hem/onc -- II. GI, neurology, rheumatology, endocrinology -- III. CV, dermatology, GU, orthopedics, general surgery, peds.
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    Medical professionalism from the patient's perspective: is there an advocate in the house? / Martha E. Gaines, Rachel Grob, Mark J. Schlesinger, and Sarah Davis -- The Hippocratic Oath as an example of professional conduct / Howard Markel -- Professionalism and politics in the United Kingdom / Carol Black, Cyril Chantler -- The role of specialty boards in promoting professionalism: the case of the American Board of Internal Medicine / Clarence H. Braddock III, Eric S. Holmboe, Christine K. Cassel -- Medical professionalism in the twenty-first century / Catherine D. DeAngelis -- Professionalism and nursing: a quest or an accomplishment? / Kathleen M. White -- Public health: the "population" as patient / Lawrence O. Gostin -- Exploring the role of law and legal systems in the therapeutic relationship / James G. Hodge, Jr. -- Professionalism and fiduciary responsibilities in health care leadership / Phil B. Fontanarosa -- Professionalism, medicine, and religion / Patricia M. Fosarelli -- Professionalism: the science of care and the art of medicine / James C. Harris.
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    "But doctor, it takes three tests to find the bottom" -- This better not be serious-I've got a plane to catch -- Whew! the tests are negative, and I've got a plane to catch -- Taking my lumps: biopsy blues -- "Once per lethal disease": coping with chemo -- "How can you know I'm in remission?" -- What's so special about fifty-five? -- Graduation to the bone marrow unit -- "Zap it to me": staring into a Hiroshima-dose of radiation -- Hospital arrest -- My re-birthday -- How much risk is too much? -- Can't I stay another day? -- Darth Vader in pink -- A delicate balance -- Size matters -- In cancer, perfect is important -- "I think your kidneys did you a favor" -- A successful partnership -- You and your docs: allies, not adversaries.
  • History and physical examination : art and science -- Subtleties of medical history taking -- Patient-centered interviewing -- Clinician-centered interviewing -- Evidence-based clinical decision making -- Dizziness -- Fatigue -- Fever -- Headache -- Insomnia -- Lymphadenopathy -- Night sweats -- Muscle weakness -- Weight gain -- Weight loss -- Red eye -- Ear pain -- Hearing loss -- Tinnitus -- Sore throat -- Inflammatory dermatoses (rashes) -- Pruritus -- Hair loss -- Cough -- Dyspnea -- Hemoptysis -- Chest pain -- Palpitations -- Syncope -- Edema -- Abdominal pain -- Constipation -- Diarrhea -- Dysepsia -- Dysphagia -- Acute gastrointestinal bleeding -- Jaundice -- Nausea and vomiting -- Anorectal pain -- Dysuria -- Hematuria -- Flank pain -- Erectile dysfunction -- Urinary incontinence -- Scrotal pain -- Amenorrhea -- Breast complaints -- Pelvic pain -- Vaginitis -- Abnormal vaginal bleeding -- Neck pain -- Shoulder pain -- Arm and hand pain -- Low back pain -- Buttock, hip, and thigh pain -- Knee and calf pain -- Foot and ankle pain -- Confusion -- Memory loss -- Diplopia -- Gait abnormalities -- Tremor -- Anxiety -- Depressed mood -- The case presentation.
  • "Patient Preparation for Bariatric Surgery provides a comprehensive and state of the art review of all aspects of the patient preparation process, The text reviews current literature and controversies involving sources of referrals and the difficulties encountered by primary care physicians in managing patients with extreme obesity. Strategies for addressing this problem and integrating primary care physicians in comprehensive obesity programs are presented. The text also reviews current indications for surgery and the current patient access limitations that have resulted in the need for revised surgical indications based more on medical need than mere extent of obesity. Written by an authority in the field, Patient Preparation for Bariatric Surgery is a valuable resource for bariatric surgeons, bariatric physicians and all allied health personnel who manage patients with extreme obesity and will assist in the advancement of this area of surgery as well as stimulate new discovery."--Publisher's website.
  • Despite the evolution and growing awareness of patient safety, many medical professionals are not a part of this important conversation. Clinicians often believe they are too busy taking care of patients to adopt and implement patient safety initiatives and that acknowledging medical errors is an affront to their skills. Patient Safety provides clinicians with a better understanding of the prevalence, causes and solutions for medical errors; bringing best practice principles to the bedside. Written by experts from a variety of backgrounds, each chapter features an analysis of clinical cases based on the Root Cause Analysis (RCA) methodology, along with case-based discussions on various patient safety topics. The systems and processes outlined in the book are general and broadly applicable to institutions of all sizes and structures. The core ethic of medical professionals is to do no harm. Patient Safety is a comprehensive resource for physicians, nurses and students, as well as healthcare leaders and administrators for identifying, solving and preventing medical error.
  • "With coverage ranging from the influence of professional identity in medicine and problematic nature of "human error", to the psychological and social features that characterize healthcare work, to the safety-critical aspects of interfaces and automation, this book spans the width of the human factors field and its importance for patient safety today. In addition, the book discusses topics such as accountability, just culture, and secondary victimization in the aftermath of adverse events and takes readers to the leading edge of human factors research today: complexity, systems thinking and resilience"--Provided by publisher.
  • Patient safety: what is it all about? / Schwappach, D. -- Patients with chronic kidney disease : safety aspects in the preoperative management / Malovrh, M. -- What every doctor should know about drug safety in patients with chronic kidney disease / Paparella, M., Martina, V., Rizzo, M.A., Gallieni, M. -- Patient safety in vascular access patients on hemodialysis : contrast agents and renal function / Vogt, B. -- Contrast agents and ionization with respect to safety for patients and doctors / von Tengg-Kobligkl, H., Karal, L., Klinkl, T., Khanichehl, E., Heverhagenl, J.T., Böhml, I.B. -- Cardiac safety in vascular access surgery and maintenance / Malik, J., Kudlicka, J., Tesar, V., Linhart, A. -- Simulation in vascular access surgery / Widmer, M.K., Widmer, L.W., Schmidli, J., Wyss, T.R., Davidson, I. -- Team training to establish a safety culture in dialysis access surgery / Davidson, I., Slakey, D., Widmer, M.K., Nolen, B., Ross, J. -- How to perform safe anesthesia in patients with end-stage renal disease / Seidl C., Eberle B. -- Careful and safe vascular access creation / Wyss, T.R., Widmer, M.K. -- Improving patient safety in vascular access : a role for individualization and patient preferences / Roy-Chaudhury, P., Verma, A. -- How to prolong the patency of vascular access / Glazer S., Saint, L., Shenoy, S. -- Safety issues in surgical and endovascular techniques to rescue failing or failed arteriovenous fistulas and arteriovenous grafts / Lazarides, M., Georgiadis, G., Argyriou, C. -- Vascular access-induced hand ischemia : risks and safe management / Sessa, C., De Lambert, A., Pirvu, A., Palacin, P., Pichot, O. -- Patient safety in peritoneal dialysis / Slakey, D.P., Davidson I. -- Safety aspects in patients on hemodialysis with catheters / Polakovi, V., Lopot, F. -- Nosocomial infections in dialysis access / Schweiger, A., Marschall, J., Trevino, S. -- How to improve vascular access care? / van Loon, M. -- The patient's role in patient safety and the importance of a dedicated vascular access team / Shemesh, D., Olsha, O., Goldin, I., Danin, S. -- Patient safety in dialysis access : education and research / Tordoir, Jan H.M., Widmer M.K.
  • Part 1. General Aspects -- 1: Quality Assessment in Surgery: Mission Impossible? -- 2. Incidence of 'Never Events' and Common Complications -- 3. Cognitive Errors -- 4. Diagnostic Errors -- 5. Technical Errors -- 6. The Missed Injury: A 'Preoperative Complication' -- 7. Non-Technical Aspects of Safe Surgical Performance -- 8. Postoperative Monitoring for Clinical Deterioration -- 9. Effective Communication- Tips and Tricks -- 10. Professionalism in Health Care -- 11. Accountability in the Medical Profession -- 12. The Role of the Surgical Second Opinion -- 13. Compliance to Patient Safety Culture -- 14. The Universal Protocol: Pitfalls and Pearls -- 15. Patient Safety in Graduate and Continuing Medical Education -- 16. Translation of Aviation Safety Principals to Patient Safety in Surgery -- 17. Handovers: The 'Hidden Threat' to Patient Safety -- 18. Public Safety-Net Hospitals- The Denver Health Model -- 19. Electronic Health Records and Patient Safety -- 20. Research and Patient Safety -- Part 2. The Surgeon's Perspective -- 21. The Surgery Morbidity and Mortality Conference -- 22. Reporting of Complications -- 23. Disclosure of Complications -- 24. Surgical Quality Improvement -- 25. Surgical Safety Checklists -- Part 3. Other Perspectives -- 26. The Anesthesia Perspective -- 27. The Nursing Perspective -- 28. The Patient's and Patient Family's Perspective -- 29. The Ethical Perspective -- 30. Patient Safety- A Perspective from the Developing World -- Part 4. Case Scenarios -- 31. Improving Operating Room Safety: A Success Story -- 32. Management of Unanticipated Outcomes: A Case Scenario -- 33. The Preventable Death of Michael Skolnik: An Imperative for Shared Decision-Making -- Epilogue -- Appendices.
  • "Each year a vast sum of money is spent on health care around the globe and patient safety has become a serious global public health issue. Filled with up-to-date information, this book demonstrates how to handle patient safety-related problems by using methods developed in the area of engineering. It contains a chapter on mathematical concepts and another chapter on introductory material on safety and human factors considered essential to understand materials presented in subsequent chapters. The author's presentation covers topics in such a manner that readers will require no previous knowledge to understand the concepts"--Provided by publisher.
  • Integrating State-of-the-Art Computational Modeling with Clinical Practice: The Promise of Numerical Methods / David E. Krummen, Gainyu Oshodi and Sanjiv M. Narayan -- Patient-Specific Modeling of Cardiovascular Dynamics with a Major Role for Adaptation / Theo Arts, Joost Lumens, Wilco Kroon, Dirk Donker and Frits Prinzen, et al. -- Patient-Specific Modeling of Structure and Function of Cardiac Cells / Frank B. Sachse -- Studies of Therapeutic Strategies for Atrial Fibrillation Based on a Biophysical Model of the Human Atria / Laurent Uldry, Nathalie Virag, Jean-Marc Vesin and Lukas Kappenberger -- Patient-Specific Modeling for Critical Care / Maxwell Lewis Neal -- Biomechanical Analysis of Abdominal Aortic Aneurysms / Lambert Speelman, Mariëlle Bosboom, Geert W. H. Schurink and Frans N. v.d. Vosse -- The Cardiac Atlas Project: Towards a Map of the Heart / Michael Backhaus, Jae Do Chung, Brett R. Cowan, Carissa G. Fonseca and Wenchao Tao, et al. -- In Vivo Myocardial Material Properties and Stress Distributions in Normal and Failing Human Hearts / Jonathan F. Wenk, Zhihong Zhang, Guangming Cheng, Kay Sun and Joseph C. Walker, et al. -- Modeling of Whole-Heart Electrophysiology and Mechanics: Toward Patient-Specific Simulations / Fijoy Vadakkumpadan, Viatcheslav Gurev, Jason Constantino, Hermenegild Arevalo and Natalia Trayanova -- Personalized Computational Models of the Heart for Cardiac Resynchronization Therapy / Maxime Sermesant and Reza Razavi -- Patient-Specific Modeling of Hypoxic Response and Microvasculature Dynamics / Joanna Nathan and Amina Ann Qutub -- A Computational Framework for Patient-Specific Multi-Scale Cardiac Modeling / Jazmin Aguado-Sierra, Roy C. P. Kerckhoffs, Fred Lionetti, Darlene Hunt and Chris Villongco, et al.
  • Patient Surveillance After Cancer Treatment covers the history of cancer patient surveillance after curative-intent treatment, the rationale, the methodologies used in the past and at present, the methodologies that will probably emerge in the future, the costs of surveillance, the definitions of various terms used in the field, and how those who are interested in the topic can get more information about it from the internet. The secondary focus of the book is to publicize the need for well-designed, adequately powered randomized clinical trials comparing two (or more) surveillance strategies for each type of cancer.The audience includes all oncologists, cancer researchers, medical economists and policy makers in government and insurance companies, and finally, interested patients.This book is part of the Current Clinical Oncology series, which provides cutting-edge knowledge of cancer diagnosis, management, and treatment. World renowned experts share their insights in all the major fields of clinical oncology. From the fundamentals of pathophysiology to the latest developments in experimental and novel therapies, Current Clinical Oncology is an indispensable resource for today's practicing oncologist.
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    Case histories in the hospital and the medical journal in enlightenment Scotland -- In his own words : using a patient's utterances to document an "unsound mind" -- Capturing insanity : the wedding of photography and physiognomy in the mid-nineteenth-century medical journal article -- Asylum notes : the historical antecedents of psychiatry's case histories -- The Freudian hiatus : psychoanalysis and narrative in fragment of an analysis of a case of hysteria -- Case histories and the transformation of American psychiatry : near demise of a genre during the rise of a "scientific" classification system -- Psychotherapist as author : case reports, classification, and categorization (with Doris Ravotas) -- In retrospect : a case for historical narrative inquiry.
  • The recent history of medicine is one of great biological and technological advances. Diagnoses are being made earlier, diseases caught sooner, patients living longer. And yet there is one area that lags behind the rest of the field: despite the efforts of graduate courses and training manuals, too many doctors still find communication a challenge. In Patient-Centered Medicine in Transition, the focus is not on skills or tools but on context to improve communication not only with patients, but between colleagues, with management, and within and across teams. Rigorous and readable, this timely manifesto presents new models of team process in patient-centered care, emphasizing their value in reducing harmful medical errors and improving patient care, safety, and outcomes. Further, the author provides significant research evidence supporting democratic approaches to communication in medicine while also addressing vital questions of ethics, empathy, gender dynamics, and physician self-care. Included in the coverage: The epidemic of communication hypocompetence. Patient-centeredness without a center. How doctors think can be judged from how they listen and speak. Working and learning in teams in the new era of health care. Blunting Occam's Razor: team process and complexity theory. Building a collaborative community in medical education research. Patient-Centered Medicine in Transition offers a bold new reconceptualization of an important topic and a roadmap to new frontiers in practice to be read and discussed by researchers and practitioners in medical education.
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  • "Covering conceptual and statistical methods, this book discusses the issues related to measuring and interpreting patient reported outcomes (PROs). It begins with a review and background information and then covers measurement scales, validity and reliability, item response theory, and missing data. The book also describes various statistical analysis techniques, including exploratory, cross-sectional, and longitudinal data analysis, and highlights the practical interpretation and application of the techniques in clinical and pharmaceutical settings. SAS code for all methods is available in an appendix and online"--Provided by publisher.
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  • Handling of the lymph node biopsy -- Immunohistology and other diagnostic techniques -- Anatomical and functional components -- Nodular lymphoid infiltrates -- Diffuse lymphoid infiltrations -- Defining microscopic features -- Nodal involvement by leukemias and extranodal lymphomas -- Needle core biopsies and aspirates.
  • Section 1. Induction and patterning of the CNS and PNS -- section 2. Generation of neuronal diversity -- section 3. Development of glia, blood vessels, choroid plexus, immune cells in the nervous system.
  • Review of immunology -- Immunology of IgE-mediated and other hypersensitivity responses -- Biochemical mediators of allergic reactions -- Evaluation and management of immune deficiency in allergy practice -- Evaluation of eosinophilia -- Allergens and other factors important in atopic disease -- Airborne pollen prevalence in the United States -- Diagnosis of immediate hypersensitivity -- Physiologic and biologic evaluation of allergic lung diseases -- Radiologic evaluation of allergic and related diseases of the upper airway -- Radiologic evaluation of allergic and related diseases of the lower airway -- Chronic rhinosinusitis role of rhinoscopy and surgery -- Principles of immunologic management of allergic diseases due to extrinsic antigens -- Anaphylaxis -- Allergy to stinging insects -- Erythema multiforme, Stevens-Johnson Syndrome, and toxic epidermal necrolysis -- Drug allergy -- Food allergies -- Asthma -- The infant and toddler with asthma -- Management of acute severe asthma -- Asthma clinical trials -- Hypersensitivity pneumonitis -- Allergic bronchopulmonary aspergillosis -- Occupational immunlogic lung disease -- Allergic rhinitis -- Nasal polyposis, sinusitis, and nonallergic rhinitis -- Allergic diseases of the eye and ear -- Atopic dermatitis -- Contact dermatitis -- Urticaria, angioedema, and hereditary angioedema -- Approach to the patient with pruritus -- Antihistamines -- β [beta] agonists -- Corticosteroids in treatment of allergic diseases -- Other antiallergic drugs: cromolyn, nedocromil, antileukotrienes, anticholinergics, and theophylline -- Delivery devices for inhaled medications -- Novel immunologic therapies -- Allergic disorders and pregnancy -- Eosinophilic esophagitis -- Chronic cough -- Sleep disorders in the allergic patient -- Management of the psychologically complicated patient -- Controversial and unproved methods in allergy diagnosis and treatment.
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    v. 1. General principles -- v. 2A, Toxicology ; v. 3. Theory and rationale of industrial hygiene practice.
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    v. 1, pt. A-B. General principles -- v. 2, pt. A-F. Toxicology.
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    "On September 2, 1971, the chemist Paul Lauterbur had an idea that would change the practice of medical research. Considering recent research findings about the use of nuclear magnetic resonance (NMR) signals to detect tumors in tissue samples, Lauterbur realized that the information from NMR signals could be recovered in the form of images -- and thus obtained noninvasively from a living subject. It was an unexpected epiphany: he was eating a hamburger at the time. Lauterbur rushed out to buy a notebook in which to work out his idea; he completed his notes a few days later. He had discovered the basic method used in all MRI scanners around the world, and for this discovery he would share the Nobel Prize for Physiology or Medicine in 2003. This book, by Lauterbur's wife and scientific partner, M. Joan Dawson, is the story of Paul Lauterbur's discovery and the subsequent development of the most important medical diagnostic tool since the X-ray. With MRI, Lauterbur had discovered an entirely new principle of imaging. Dawson explains the science behind the discovery and describes Lauterbur's development of the idea, his steadfastness in the face of widespread skepticism and criticism, and related work by other scientists including Peter Mansfield (Lauterbur's Nobel co-recipient), and Raymond Damadian (who famously feuded with Lauterbur over credit for the ideas behind MRI). She offers not only the story of one man's passion for his work but also a case study of how science is actually done: a flash of insight followed by years of painstaking work."--Jacket.
  • PCR cloning protocols. 2nd ed. 2002
    Springer Protocols
  • Part 1. PCR Fundamentals -- Part 2. Clinical Aspects and Diagnosis of Infectious Disease -- Part 3. PCR Protocols for Bacterial Pathogens -- Part 4. PCR Protocols for Viral Pathogens -- Part 5. PCR Protocols for Fungal and Parasitic Pathogens -- Part 6. Susceptibility Screening.
  • PCR mutation detection protocols 2002
    Springer Protocols
  • Conformation-Sensitive Capillary Electrophoresis / Emma Jane Ashton -- Conformation Sensitive Gel Electrophoresis / Marian Hill -- Denaturing HPLC for Mutation Screening / Mike Mitchell, Jacqueline Cutler -- In Situ Detection of Human Papillomavirus DNA After PCR-Amplification / Gerard J. Nuovo -- LATE-PCR and Allied Technologies: Real-Time Detection Strategies for Rapid, Reliable Diagnosis from Single Cells / Kenneth E. Pierce, Lawrence J. Wangh -- Long-PCR Amplification of Human Genomic DNA / Stephen Keeney -- Human Papilloma Virus Strain Detection Utilising Custom-Designed Oligonucleotide Microarrays / Duncan Ayers, Mark Platt, Farzad Javad, Philip J. Day -- Multiplex Ligation-Dependent Probe Amplification (MLPA®) for the Detection of Copy Number Variation in Genomic Sequences / Petra G. Os, Jan P. Schouten -- Screening for Genomic Rearrangements by Multiplex PCR/Liquid Chromatography / Claude Houdayer, Catherine Dehainault, Marion Gauthier-Villars, Dominique Stoppa-Lyonnet -- Mutation Surveyor: Software for DNA Sequence Analysis / Jayne A. Minton, Sarah E. Flanagan, Sian Ellard -- Non-invasive Prenatal Diagnosis / Cathy Meaney, Gail Norbury -- Automated DNA Sequencing / Yvonne Wallis, Natalie Morrell -- Phylogenetic Microarrays for Cultivation-Independent Identification and Metabolic Characterization of Microorganisms in Complex Samples / Alexander Loy, Michael Pester, Doris Steger -- Prenatal Detection of Chromosome Aneuploidy by Quantitative-Fluorescence PCR / Kathy Mann, Erwin Petek, Barbara Pertl -- Use of Robotics in High-Throughput DNA Sequencing / Stephen Keeney -- Detection of Factor V Leiden and Prothrombin c.20210G>A Allele by Roche Diagnostics LightCycler® / Peter C. Cooper -- RT-PCR for the Detection of Translocations in Bone and Soft Tissue Tumours in Formalin-Fixed Paraffin-Embedded Tissues / Ann Williams, D. Chas Mangham -- Detection of Minimal Residual Disease in Leukaemia by RT-PCR / Joanne Mason, Mike Griffiths -- Mutation Detection by Southern Blotting / Gillian Mellars, Keith Gomez.
  • PCR protocols. 3rd ed. 2011
    Springer Protocols
    Setup of a PCR Laboratory / Zaheer Khan -- Long-Range PCR with a DNA Polymerase Fusion / Holly H. Hogrefe, Michael C. Borns -- Isolation of Genomic Insertion Sites of Proviruses Using Splinkerette-PCR-Based Procedures / Bin Yin -- Lariat-Dependent Nested PCR for Flanking Sequence Determination / Daniel J. Park -- CODEHOP PCR and CODEHOP PCR Primer Design / Jeannette P. Staheli, Richard Boyce, Dina Kovarik, Timothy M. Rose -- Sequencing of Difficult DNA Regions by SAM Sequencing / Keith R. Mitchelson -- A Global Single-Cell cDNA Amplification Method for Quantitative Microarray Analysis / Kazuki Kurimoto, Mitinori Saitou -- Quantitation of MicroRNAs by Real-Time RT-qPCR / Caifu Chen, Ruoying Tan, Linda Wong, Richard Fekete, Jason Halsey -- High-Throughput SuperSAGE / Hideo Matsumura, Kentaro Yoshida, Shujun Luo, Detlev H. Krüger, Günter Kahl, Gary P. Schroth, Ryohei Terauchi -- Deep Cap Analysis of Gene Expression / Junpei Kurosawa, Hiromi Nishiyori, Yoshihide Hayashizaki -- Linking Emulsion PCR Haplotype Analysis / James G. Wetmur, Jia Chen -- PAP-LMPCR: An Improved, Sequence-Selective Method for the In Vivo Analysis of Transcription Factor Occupancy and Chromatin Fine Structure / Richard Ingram, Arthur Riggs, Constanze Bonifer -- The Many Faces of MLPA / Thomas Ohnesorg, Erin Turbitt, Stefan J. White -- Assessing Gene-Specific Methylation Using HRM-Based Analysis / Ee Ming Wong, Alexander Dobrovic -- Alu PCR / Maurizio Cardelli -- Asynchronous PCR / Caifu Chen, David Ruff, Jason Halsey -- Novel Applications of PCR Through the Use of DNA Substrates / Stuart M. Wilson -- Enhanced Solid Phase PCR for Increased Loading of Amplicon onto Solid Support / Daniel J. Park -- Application of Blocking Oligonucleotides to Improve Signal-to-Noise Ratio in a PCR / Hege Vestheim, Bruce E. Deagle, Simon N. Jarman -- Asymmetric Overlap Extension PCR Method for Site-Directed Mutagenesis / Yue-Hua Xiao, Yan Pei -- Ribosome Display: A Technology for Selecting and Evolving Proteins from Large Libraries / Birgit Dreier, Andreas Plückthun -- GLOBE: Analysis of DNA-Protein Interaction Analysis / Takaaki Kojima, Hideo Nakano -- PCR DNA-Array Profiling of DNA-Binding Transcription Factor Activities in Adult Mouse Tissues / Yimin Sun, Jing Cheng, Keith R. Mitchelson -- Nucleotide Exchange and Excision Technology DNA Shuffling and Directed Evolution / Janina Speck, Sabine C. Stebel, Katja M. Arndt, Kristian M. Müller.
  • "A technique used to amplify the number of copies of a specific region of DNA, the polymerase chain reaction (PCR) is at the forefront of the dramatic development of biochemistry. This text provides the tools for developing innovative approaches to using this leading technology. It includes theoretical considerations, discussions, and a selection of state-of-the-art techniques for mutation studies, clinical diagnosis, and the detection of food-borne pathogens. This edition also discusses the preparation of PCR experiments, includes examples of analytical PCR divided into qualitative and quantitative applications, and explores preparative methods that address DNA generation for further analysis and in vitro evolution"--Provided by publisher.
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  • Pearls and Pitfalls in Cosmetic Oculoplastic Surgery, Second Edition addresses the need among surgeons for cleanly distilled and clinically relevant information. The second edition of this popular text highlights the changes and updates to the ever expanding field of facial cosmetic surgery. There are updates regarding the advances, for example in blepharoplasty techniques, fillers and filler techniques, periorbital fat grafting, brow lifting techniques, and midface rejuvenation. Additionally, nearly every chapter has full color illustrations to bring each one to life. This concise and practical "how to" book is written and edited by experts in their fields and offers "here?s how I do it" advice on the most commonly performed procedures. Each chapter becomes the voice of an expert and experienced colleague, reminding readers of the pearls and pitfalls of each procedure. These pearls will lead to more efficient techniques, fewer complications, and enhance outcomes for physicians and their patients.
  • Optic Nerve: The Glaucomatous Optic Nerve -- Optic Nerve: Clinical Examination -- Optic Nerve: Heidelberg Retinal Tomography -- Optic Nerve: Scanning Laser Polarimetry -- Optic Nerve: Optical Coherence Tomography -- Optic Nerve: Comparison of Technologies -- Optic Nerve: Atypical Nerves and Nerve Findings -- IOP: The Importance of Intraocular Pressure -- IOP: Instruments to Measure IOP -- IOP: Central Corneal Thickness -- IOP: Corneal Hysteresis -- IOP: Target Pressures -- IOP: Fluctuation -- Gonioscopy: Why Do Indentation? -- Visual Fields: Visual Field Test Strategies -- Visual Fields: Fluctuation and Progression -- Visual Fields: Field Interpretation -- Other Tests in Glaucoma: Genetic Testing -- Other Testing in Glaucoma: Optic Nerve Blood Flow I -- Other Tests in Glaucoma: Optic Nerve Blood Flow II -- Other Tests in Glaucoma: Multifocal Visual Evoked Potential -- Risk Factors -- Risk Factors: The Risk Calculator - Medical Treatment: First Line Agents and Monotherapy -- Medical Treatment: The Pregnant and Nursing Woman -- Medical Treatment: Carbonic Anhydrase Inhibitors -- Medical Treatment: Osmotic Agents -- Medical Treatment: Neuroprotection -- Medical Treatment: Treated vs. Untreated Glaucoma and Ocular Hypertension -- Medical Treatment: Adherence and Persistence -- Medical Treatment: Alternative Medicine and Glaucoma -- Procedural Treatments: Laser Trabeculoplasty -- Procedural Treatments: Endoscopic Cyclophotocoagulation -- Procedural Treatments: Transcleral Cyclophotocoagulation -- Procedural Treatments: Trabeculectomy -- Procedural Treatments: Perioperative Medication -- Procedural Treatments: Bleb Needling -- Procedural Treatments: Glaucoma Drainage Devices -- Procedural Treatments: New Surgical Options -- Procedural Treatments: Ex-PRESS Mini Glaucoma Shunt -- Procedural Treatments: Phacotrabeculectomy -- Procedural Treatments: Surgery in End-Stage Glaucoma -- Glaucomas: Managing Normal-Tension Glaucoma -- Glaucomas: Pseudoexfoliation Glaucoma -- Glaucomas: Pigment Dispersion Glaucoma and Angle Recession Glaucoma -- Glaucomas: Sturge Weber Syndrome -- Glaucomas: Glaucoma and the Cornea -- Glaucomas: Uveitic Glaucoma -- Glaucomas: Neovascular Glaucoma -- Pediatric Glaucoma: IOP, Axial Length, and Surgery Indications -- Pediatric Glaucoma: Glaucoma Medications and Steroids -- Pediatric Glaucoma: Angle Surgery and Glaucoma Drainage Devices -- Pediatric Glaucoma: Trabeculectomy and Glaucoma Drainage Devices -- Angle-Closure Glaucoma: Risk Factors -- Angle-Closure Glaucoma: Iridotomy -- Angle-Closure Glaucoma: Imaging -- Angle-Closure Glaucoma: Medical Therapy -- Angle-Closure Glaucoma: Surgical Management of Acute Angle-Closure Glaucoma -- Complications: Hypotony -- Complications: Bleb Leaks -- Complications: Blebitis.
  • Published as two individual books in its previous editions, this acclaimed reference now comes to you as one comprehensive two-volume resource, covering the entire range of esophageal and thoracic surgery for adults and children. Sixty nine brand-new chapters and 92 new authors deliver state-of-the-art, clear how-to-do-it guidance on the latest surgical techniques for the treatment of lung infections, lung cancer, benign conditions, trauma, reflux, and more-so you can effectively manage every common and uncommon condition you encounter. A new full-color design presents outstanding visual guidance that shows you exactly how to proceed, and a logical organization throughout makes reference easy. As an Expert Consult title, this thoroughly updated 3rd edition comes with access to the complete contents online, fully searchable-enabling you to consult it rapidly from any computer with an Internet connection. Addresses all surgical diseases of the chest wall, chest cavity, upper airway, lungs, pleura, and diaphragm in adults and children, giving you the comprehensive coverage you need for the patients you see. Presents clinical commentary at the end of each chapter that offers you a variety of viewpoints regarding the pros, cons, and complications associated with the techniques used to treat a patient.
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  • Role of mitochondria in steroidogenesis / Miller, W.L. -- The physiology and biochemistry of adrenarche / Auchus, R.J. -- Update on the corticomedullary interaction in the adrenal gland / Haase, M., Willenberg, H.S., Bornstein, S.R. -- Role of DAX-1 (NR0B1) and steroidogenic factor-1 (NR5A1) in human adrenal function / El-Khairi, R. ... [et al.] -- Functional and physiological consequences of STAR deficiency : role in lipoid congenital adrenal hyperplasia / King, S.R., Bhangoo, A., Stocco, D.M. -- P450 side-chain cleavage deficiency : a rare cause of congenital adrenal hyperplasia / Hauffa, B., Hiort, O. -- Clinical and biochemical consequences of P450 oxidoreductase deficiency / Flück, C.E., Pandey, A.V. -- Molecular genetics of 21-hydroxylase deficiency / Wedell, A -- Brain development and cognitive, psychosocial, and psychiatric functioning in classical 21-hydroxylase deficiency / Meyer-Bahlburg, H.F.L. -- Long-term outcome of prenatal dexamethasone treatment of 21-hydroxylase deficiency / Lajic, S., Nordenstrom, A., Hirvikoski, T. -- Role of genetic variation in regulation of aldosterone biosynthesis / Alvarez-Madrazo, S., Connell, J.M., Freel, E.M. -- Circadian clock-mediated regulation of target-tissue sensitivity to glucocorticoids : implications for cardiometabolic diseases / Kino, T., Chrousos, G.P. -- Glucocorticoid resistance / van Rossum, E.F.C., van den Akker, E.L.T. -- Mineralocorticoid receptor gene variants as determinants of HPA axis regulation and behavior / DeRijk, R.H. ... [et al.] -- Adrenoleukodystrophy / Cappa, M. ... [et al.] -- Autoimmune addison's disease / Betterle, C., Morlin, L. -- Optimal glucocorticoid therapy / Debono, M., Ross, R.J. -- Modulation of glucocorticoid metabolism by the GH-IGF-I axis / Neggers, S.J.C.M.M., van der Lely, A.J. -- Effects of glucocorticoids on the growth plate / Lui, J.C., Baron, J. -- Growth hormone treatment in children on chronic glucorticoid therapy / Savage, M.O., Simon, D., Czernichow, P.C. -- Ancient history of congenital adrenal hyperplasia / New, M.I.
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    Course overview -- Systematic approach to the seriously ill or injured child -- Effective resuscitation team dynamics -- Recognition of respiratory distress and failure -- Management of respiratory distress and failure -- Recognition of shock -- Management of shock -- Recognition and management of bradycardia -- Recognition and management of tachycardia -- Recognition and management of cardiac arrest -- Postresuscitation management -- Pharmacology.
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    The sound phenomena investigated / J. Hirschberg, T. Szende, P. Koltai -- Review of the literature. historical background / J. Hirschberg -- Patients / J. Hirschberg, P. Koltai, Z. Farkas -- Methods -- Characterization and acoustic description of the most commonly occurring sound signals / T. Szende, J. Hirschberg -- Airway and neurological diseases with pathological sounds.
  • For the first time the editors of this volume have brought together text, illustrations and high-definition videos to create an expert video atlas in the field of pediatric airway surgery. The publication which includes the book and free online access to the videos provides a detailed review of the pros and cons and clinical pearls involved in various modes of pediatric airway surgery. Discussed are all the main open airway surgeries including laryngotracheal reconstruction, cricotracheal resection, tracheal resection and re-anastomosis, and slide tracheoplasty. Further covered is a range of endoscopic procedures such as endoscopic repair of laryngeal clefts and endoscopic treatment of vocal fold immobility.The high-definition videos with audio overlay and the text complement provide an excellent detailed instruction manual for surgeons willing to carry out these operations. This publication is designed for all levels, from medical student through residency and fellowship as well as the pediatric otolaryngologist or pediatric surgeon preparing for pediatric airway surgery.
  • The compromised pediatric airway: challenges facing families and physicians -- Applied surgical anatomy of the larynx and trachea -- Clinical evaluation of airway obstruction -- Equipment and instrumentation for diagnostic and therapeutic endoscopy -- Endoscopic assessment of the compromised pediatric airway -- Laryngomalacia (LM) -- Vocal cord paralysis (VCP) -- Congenital subglottic stenosis (C-SGS) -- Laryngeal web and atresia -- Subglottic haemangioma (SGH) -- Ductal cysts, saccular cysts and laryngoceles -- Laryngeal and tracheal clefts -- Congenital tracheal anomalies -- Acquired post-intubation and tracheostomy-related stenoses -- External laryngeal trauma -- Neoplastic lesions of the larynx and trachea -- Preoperative assessment, indications for surgery and parental counseling -- Endoscopic techniques for laryngotracheal stenosis -- Laryngotracheoplasty and laryngotracheal reconstruction -- Partial cricotracheal resection -- Tracheotomy -- Tracheal resection and anastomosis -- Revision surgery.
  • Between the growing numbers of children and adolescents playing sports and the increased attention to head injuries by the larger sports community and the general public, pediatric concussions are emerging as a major concern. And as practitioners are seeing more young clients with head injuries, questions arise about age-appropriate assessment, diagnosis, treatment, and return to activity. Pediatric and Adolescent Concussion: Diagnosis, Management, and Outcomes offers evidence-based guidelines where few previously existed. This comprehensive volume clearly explains the effects of traumatic injury on the developing brain in sports- and non-sports-related contexts, and establishes a framework for immediate and long-term management, especially the crucial first 24 hours. Chapters provide a basic grounding in its subject with a history of concussion as a medical entity and a review of definitional and classification issues, take the reader through the steps of a neuropsychological evaluation, pinpoint post-injury issues, and offer strategies for the prevention of further or future injury. Pediatric and Adolescent Concussion: Diagnosis, Management, and Outcomes serves as both educational resource and practical framework for a wide array of professionals, including neuropsychologists, sports medicine physicians, child psychologists and psychiatrists, pediatric and family physicians, athletic trainers, social workers, and educators.
  • The extended contents of this second edition reflect the growing spectrum of topics in pediatric and adolescent gynecology. Like its predecessor, this book addresses the most common gynecological problems encountered in childhood medicine, including endocrinological and surgical aspects. New chapters place particular emphasis on an update of technological aspects such as ultrasound, molecular genetics, surgery in sex disorders and new problems encountered in reproductive medicine. The book opens with a comprehensive description of the background of infant and adolescent gynecology and diagnostic tools. Several chapters are devoted to the various pathologies encountered in prepubertal and adolescent girls. Contemporary social issues such as sexual abuse, sexually transmitted diseases, contraception for teenagers and teenage pregnancy are also discussed in detail. Presenting a clear plan for clinical management and treatment of frequently encountered problems in prepubertal and adolescent girls, this book should be read by pediatricians, endocrinologists, gynecologists and family practitioners.
  • Office evaluation of the child and adolescent -- Ambiguous genitalia in the newborn -- Vulvovaginal problems in the prepubertal child -- The physiology of puberty -- Precocious puberty -- Delayed puberty -- Amenorrhea in the adolescent -- Dysfunctional uterine bleeding -- Androgen abnormalities in the adolescent girl -- Structural abnormalities of the female reproductive tract -- Gynecologic pain : dysmenorrhea, accute and chronic pelvic pain, endometriosis, and premenstrual syndrome -- Education of the child and adolescent -- Pediatric urology in the pediatric and adolescent girl -- Vulvovaginal complaints in the adolescent -- Bacterial sexually transmitted infections : gonorrhea, chlamydia, pelvic inflammatory disease, and syphilis -- Human immunodeficiency virus in young women -- Human papillomavirus infection in children and adolescents -- Benign and malignant ovarian masses -- The breast : examination and lesions -- Contraception -- Teen pregnancy -- Adolescent sexuality -- Gynecologic issues in young women with chronic diseases -- Sexual abuse in the child and adolescent -- Complementary and alternative medicine for gynecology patients -- Legal issues in pediatric and adolescent gynecology.
  • This handy volume focuses on the evaluation and treatment of a wide range of sports injuries, in relation to the Tanner stage of sexual development in young athletes. Recognized leaders in each subspecialty illustrate their own treatment preferences, and a series of detailed chapters address the injuries likely to be encountered in different parts of the body, including the spine, shoulder, elbow, wrist and hand, hip, knee, ankle, and feet. Among the topics that receive particular attention are epiphyseal-physeal injuries, the still controversial issue of capsular ligament tears and the impact of their treatment on joint and bone development, and stress syndromes of the musculoskeletal system. Helpful algorithms covering the diagnosis and treatment of ligament tears are included, and advice is provided on when to return an athlete to training. One chapter is devoted to non-sports-related pathologies that have to be considered in the differential diagnosis of sports injuries in adolescents. Written by a multidisciplinary team of experts, this volume will be an excellent guide in diagnosis and in evaluating the impact of treatments for all professionals dealing with young athletes; orthopedic surgeons, physiotherapists, general practitioners and athletic trainers.
  • This book provides a comprehensive reference for health care providers of children and adolescents with urologic conditions. The first section covers the principles of each radiologic modality as well as radiation safety and the history of uroradiology. The second section integrates the lessons of the first section into specific urologic conditions arranged anatomically and includes additional unique conditions.
  • This book is the first in a two-volume set of textbooks and focuses on outcomes analysis in pediatric cardiac care, supporting the coverage of quality improvement and patient safety in its sister title. There has been a huge research effort undertaken in pediatric and congenital cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on implementation science in terms of continuous quality improvements and safety science and systems. Pediatric and Congenital Cardiac Care: Volume 1 ? Outcomes Analysis reveals the remarkable developments that have been seen in the fields of pediatric cardiology and cardiac surgery. This unique collaboration between four Editors from disparate medical disciplines (cardiac surgery, cardiology, anesthesia, and critical care) incorporates an international community of scholarship with articles by luminaries and cutting edge thinkers on the current and future status of pediatric and congenital cardiac care. The goal of this and its companion volume is to understand and advance the profession and its activities, to use common terms, and to improve the management of risk and safety in order to enhance pediatric and congenital cardiac care.
  • This book is the second in a two-volume set of textbooks and focuses on quality improvement and patient safety, supporting the coverage of outcomes analysis in its sister title. There has been a huge research effort undertaken in pediatric cardiac care to understand and measure what is done, to establish collaborative definitions and tools of measurement, and to determine robust benchmarks and methodologies to analyze outcomes. This book concentrates on implementation science in terms of continuous quality improvements and safety science and systems. Pediatric and Congenital Cardiac Care: Volume 2 - Quality Improvement and Patient Safety reveals the remarkable developments that have been seen in the fields of pediatric cardiology and cardiac surgery. This unique collaboration between four Editors from disparate medical disciplines (cardiac surgery, cardiology, anesthesia, and critical care) incorporates an international community of scholarship with articles by luminaries and cutting edge thinkers on the current and future status of pediatric and congenital cardiac care. The goal of this and its companion volume is to understand and advance the profession and its activities, to use common terms, and to improve the management of risk and safety in order to enhance pediatric and congenital cardiac care.
  • Pediatric and Congenital Cardiology, Cardiac Surgery and Intensive Care provides a consistent and comprehensive approach to multiple congenital and acquired cardiac pathologies pre, peri and postoperatively, with the use of algorhythms, guidelines and current research issues. Included with this book are interactive videos with the most common interventions, online access to practical learning activities, and to the comprehensive Aristotle score and database. This reference work satisfies the need for a universal and practical review of management of critically ill children and adults with congenital heart disease, based upon taskforce decisions and the cumulative experience of the world leaders in the field.
  • This book provides a comprehensive overview of current standards of anesthesia and intensive care in neonates and children, with a view to promoting standardization in clinical practice. The first part of the book, devoted to issues in intensive care, opens by considering scoring systems for the assessment of sick children. The diagnosis, prevention, and management of ventilator-associated pneumonia are then discussed, and the roles of high-frequency oscillatory ventilation and noninvasive respiratory support are reviewed. Further chapters address procedural sedation and analgesia in children, the progress toward 'open' ICUs with liberal visiting policies, and advances in long-term home mechanical ventilation.In the second part of the book, a range of important topics in anesthesia and perioperative medicine are discussed. After a review of safety issues, current trends in pediatric regional and locoregional anesthesia are described and a synopsis is provided on current knowledge regarding the use of central blocks in infants and children. Subsequent chapters are devoted to awareness monitoring, single-lung ventilation techniques, anesthesia in the context of severe prematurity, and emergence delirium.Pediatric Anesthesia, Intensive Care and Pain: Standardization in Clinical Practice will be an extremely useful source of information for both novices and more experienced practitioners in the field.
  • Newborn medicine -- Respiratory system -- Surgery -- Hematology/oncology -- Cardiology -- The musculoskeletal system -- General pediatrics -- Prematurity/extreme prematurity -- Newborn emergencies -- Neuroanesthesia -- Central nervous system/orthopedics -- Otolaryngology -- Head and neck -- Ophthalmology -- Respiratory system -- Cardiac I -- Cardiac II -- Gastrointestinal disease -- Renal -- Genitourinary system -- Bone and connective tissue -- Orthopedics: scoliosis -- Skin/connective tissue/metabolic disease -- Inborn errors of metabolism -- Allergy/immunology -- Infectious diseases -- Neuromuscular disease -- Endocrinopathies -- Transplantation -- Minimally invasive surgery -- Trauma I -- Trauma II -- Regional anesthesia -- Pain management -- Burns -- Anesthesia outside the operating room -- Equipment and monitoring -- Post anesthesia care unit (PACU) -- Critical care.
  • Part I: Neurobiology and Temperament -- Fear Models in Animals and Humans -- Neurobiology of Pediatric Anxiety Disorders -- Temperamental Risk Factors for Pediatric Anxiety Disorders -- Part II: Anxiety Disorders -- Generalized Anxiety Disorder in Children and Adolescents -- Pediatric Social Phobia -- Specific Phobias -- Separation Anxiety Disorder -- Panic Disorder -- Obsessive-Compulsive Disorder in Children and Adolescents -- Posttraumatic Stress Disorder in Children and Adolescents -- Selective Mutism -- Part III: Assessment and Treatment --Assessment of Anxiety Disorders: Categorical and Dimensional Perspectives -- Cognitive-Behavioral Treatment for Pediatric Anxiety Disorders -- Psychopharmacology of Pediatric Anxiety Disorders -- Part IV: Special Topics -- Anxiety in Children with Chronic Medical Illness -- Anxiety in Children with Autism Spectrum Disorder.
  • "Advances in the biomedical sciences, especially genomics, proteomics, and metabolomics, taken together with the expanding use of electronic health records, are radically changing the IT infrastructure and software applications needed to support the transfer of knowledge from bench to bedside. Pediatric Biomedical Informatics: Computer Applications in Pediatric Research describes the core resources in informatics necessary to support biomedical research programs and how these can best be integrated with hospital systems to receive clinical information that is necessary to conduct translational research. The focus is on the authors' recent practical experiences in establishing an informatics infrastructure in a large research-intensive children's hospital. This book is intended for translational researchers and informaticians in pediatrics, but can also serve as a guide to all institutions facing the challenges of developing and strengthening informatics support for biomedical research. The first section of the book discusses important technical challenges underlying computer-based pediatric research, while subsequent sections discuss informatics applications that support biobanking and a broad range of research programs. Pediatric Biomedical Informatics provides practical insights into the design, implementation, and utilization of informatics infrastructures to optimize care and research to benefit children. Dr. John Hutton is the Vice President and Director of Biomedical Informatics at Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA. He is also Professor of Pediatrics and Associate Dean for Information Services at the University of Cincinnati College of Medicine"--Provided by publisher.
  • 2012 ClinicalKey
    1. Bone cell biology: osteoclasts, osteoblasts, osteocytes / Katharine Jähn and Lynda F. Bonewald -- 2. Bone matrix and mineralization / Marc D. McKee and William G. Cole -- 3. Prenatal bone development / Fanxin Long -- 4. Postnatal bone growth: growth plate biology, bone formation, and remodeling / Christa Maes and Henry M. Kronenberg -- 5. Dental development and maturation, from the dental crypt to the final occlusion / Jean-Marc Retrouvey, Michel Goldberg and Stéphane Schwartz -- 6. Parathyroid hormone and calcium homeostasis / John T. Potts and Thomas J. gardella -- 7. Phosphate homeostasis regulatory mechanisms / Clemens Bergwitz and Harald Jüppner -- 8. Vitamin D biology / René St-Arnaud and Marie B. Demay -- 9. Peak bone mass and its regulation / Jean-Philippe Bonjour ... [et al.] -- 10. Pregnancy and lactation / Ann Prentice -- 11. Fetal mineral homeostasis / Christopher S. Kovacs -- 12. Radiology / Judith E. Adams ... [et al.] -- 13. Non-invasive techniques for bone mass measurement / Mary B. Leonard and Laura K. Bachrach -- 14. Assessment of maturation: bone age and pubertal assessment / Noël Cameron and David D. Martin -- 15. Biochemical markers of bone metabolism / Nick Shaw and Wolfgang Högler -- 16. Pediatric bone histomorphometry / frank Rauch -- 17. A diagnostic approach to skeletal dysplasias / Sheila Unger, Andrea Superti-Furga and David L. Rimoin -- 18. The spectrum of pediatric osteoporosis / Maria Luisa Bianchi and Francis H. Glorieux -- 19. Osteogenesis imperfecta / Francis H. Glorieux and David Rowe -- 20. Sclerosing bone dysplasias / Bram Perdu ... [et al.] -- 21. Parathyroid disorders / Murat Bastepe, Harald Jüppner and Rajesh V. Thakker -- 22. Fibrous dysplasia / Paolo Bianco and Shlomo Wientroub -- 23. Nutritional rickets / John M. Pettifor -- 24. Metabolic bone disease in the neonatal period and its later sequelae / Nick Bishop, Mary Pewtrell and Nick Harvey -- 25. Rickets due to hereditary abnormalities of vitamin D synthesis or action / Anthony A. Portale, Farzana Perwad and Walter L. Miller -- 26. Familial hypophosphatemia and related disorders / Ingrid A. Holm, Michael J. Econs and Thomas O. Carpenter -- 27. Hereditary tubular disorders of mineral handling / Daniella Magen and Israel Zelikovic -- 28. Hypophosphatasia / michael P. Whyte -- 29. Chronic kidney disease mineral and bone disorder / Katherine Wesseling Perry and Isidro B. Salusky -- 30. Extraskeletal bone formation / Eileen M. Shore and Frederick S. Kaplan.
  • Pediatric cancer v. 1-, 2012-
  • v. 4 Springer
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    Anesthetic and peroperative management / Monica A. Stokes -- Monitoring of the pediatric cardiac patient / Carol L. Lake and Harvey L. Edmonds -- Physiology and techniques of extracorporeal circulation in the pediatric patient / James A. DiNardo -- Profound hypothermia and circulatory arrest / James A. DiNardo -- Vital organ preservation during surgery for congenital heart disease / Emad B. Mossad and Ibrahim Farid -- Management of postbypass myocardial dysfunction / Laurie K. Davies -- Hemostasis, coagulation, and transfusion in the pediatric cardiac patient / William C. Oliver, Jr. -- Management of postbypass pulmonary hypertension and respiratory dysfunction / Angus McEwan -- -- Septal and endocardial cushion defects / Julie K. Hudson and Jayant K. Deshpande -- Tetralogy of Fallot / William A. Lell and F. Bennett Pearce -- Transposition of the great vessels / James A. DiNardo -- Anomalies of the aortic arch and valve / David A. Rosen and Kathleen R. Rosen -- Anomalies of the pulmonary valve and right ventricular outflow tract / Ian Adatia and Helen Holtby -- Tricuspid atresia / Susan Tebich -- Hypoplastic left heart syndrome / George M. Hoffman and Eckehard A.E. Stuth -- Double-outlet right ventricle / Julie K. Hudson and Jayant K. Deshpande -- Truncus arteriosus / Ian M. McKenzie -- Anomalies of systemic and pulmonary venous return / Carol L. Lake -- Abnormalities of the atrioventricular valves / Victor C. Baum -- Coronary artery anomalies / Monica A. Stokes -- Cardiomyopathies / Ian M. McKenzie and Robert G. Weintraub -- Pulmonary hypertension, persistent fetal circulation, and Eisenmenger Syndrome / Paul B. Baines and Andrew Selby -- Pediatric cardiac and lung transplantation / Linda J. Mason ... [et al.] -- Secondary vascular anomalies and cardiac tumors / Steven M. Auden -- Anesthesia for noncardiac surgery in children and adults with congenital heart disease / David Frankville -- History of pediatric cardiac anesthesia / Carol L. Lake -- Pediatric heart disease in the developing world / Annette J.M. Davis -- -- Intrauterine development of the cardiovascular system / Carol L. Lake -- Extrauterine development of the cardiovascular system / Peter D. Booker -- Pediatric anesthesia pharmacology / D. Ryan Cook, Peter J. Davis, and Richard J. Ing -- -- Preoperative evaluation and preparation of the pediatric patient with cardiac disease / Ellise Delphin, Ali Inanc Seçkin, and Roger A. Moore -- Cardiac catheterization and other radiographic examinations / Ingrid Hollinger and Alexander Mittnacht -- Pediatric electrocardiography and cardiac electrophysiology / Kevin P. Walsh -- Pediatric echocardiography / Wyman W. Lai, H. Helen Ko, and Ira A. Parness -- Postoperative care / Peter D. Booker -- Postoperative cardiovascular dysfunction: pharmacologic support / Peter D. Booker -- Postoperative respiratory function and its management / Lori A. Aronson and Catherine L. Dent -- Renal, gastrointestinal, hepatic, and neurologic dysfunction / Duncan J. Macrae -- Postoperative pain management in the pediatric cardiac patient / Andrew R. Wolf -- Anesthesia for cardiac procedures in the pediatric intensive care unit / Annette J.M. Davis -- -- Quality in pediatric cardiac anesthesia / D. Ryan Cook and Lisa Faberowski -- Teaching pediatric cardiac anesthesiology / Chris Chin and Alan Jay Schwartz.
  • Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Cardiology and Pulmonology: A Practically Painless Review presents bite-sized chunks of information that can be read and processed rapidly, helping learners to stay active while studying to understand and process new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Cardiology and Pulmonology: A Practically Painless Review is a quick and easy way to master these tricky topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up on their skills, medical students and pediatric residents doing rotations, and any busy clinician who wants to learn more about these topics while on the go.
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  • Basics and diagnostics -- Clinical history and examination in pediatric cardiology -- Electrocardiography -- Echocardiography -- Chest X-ray -- Cardiac magnetic resonance imaging and computed tomography -- Nuclear medicine in pediatric cardiology -- Pediatric exercise testing -- Cardiac catheterization -- Electrophysiology studies -- Leading synptoms -- Cyanosis -- Cardiac murmurs -- Chest pain -- Palpitations -- Syncope -- Syndromes -- Congenital heart defects -- Acquired cardiac diseases -- Cardiomyopathies -- Cardiac arrhythmias -- Heart failure -- Arterial hypertension -- Pulmonary hypertension -- Eisenmenger syndrome -- Syndromic diseases with cardiac involvement -- Treatment -- Interventional catheterization -- Postoperative pediatric cardiac treatment -- Operations with cardiopulmonary bypass -- Mechanical circulatory support systems -- Initial treatment of critically ill neonates with cardiac defects -- Heart transplantation -- Vaccinations for pediatric patients with cardiac disease -- Pharmacological treatment.
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  • Since the previous edition of Pediatric Chest Imaging was published in 2007, there have been significant advances in our understanding of chest diseases and continued development of new imaging technology and techniques. The third edition of this highly respected reference publication has been thoroughly revised and updated to reflect this progress. Due attention is paid to the increased role of hybrid imaging, and entirely new chapters cover topics such as interventional radiology, lung MRI, functional MRI, diffuse/interstitial lung disease, and cystic fibrosis. As in previous editions, the focus is on technical aspects of modern imaging modalities, their indications in pediatric chest disease, and the diagnostic information that they supply. The full range of imaging techniques and all important disorders are thoroughly covered. The editors are confident that this latest edition of Pediatric Chest Imaging will be an essential asset for pediatricians, neonatologists, cardiologists, radiologists, and pediatric radiologists everywhere. The combined expert knowledge and experience contained within its pages should contribute in further improving patient care and outcomes.
  • Family interviewing and history-taking / Richard B. Goldbloom -- Skills for culturally sensitive care / Richard B. Goldbloom -- Assessing physical growth and nutrition / Richard B. Goldbloom -- Evaluating the newborn : diagnostic approach / Alexandra A. Howlett, Krista A. Jangaard -- Assessing congenital anomalies / Mark D. Ludman -- Developmental and behavioral assessment / Sarah E. Shea -- Examining the head and neck / D. Anna Jarvis -- Examining the visual system / G. Robert LaRoche -- Evaluating the respiratory system / Daniel M. Hughes -- Cardiovascular assessment of infants and children / Andrew E. Warren, Douglas L. Roy -- Evaluating gastrointestinal symptoms / Mohsin Rashid -- Surgical assessment of the abdomen / Michael Giacomantonio -- Neurological examination / Joseph M. Dooley -- Psychiatric assessment of children and adolescents / Harriet L. MacMillan, Jan Ellen Fleming, Ellen Jamieson -- Musculoskeletal examination / Bianca A. Lang -- Clinical endocrine evaluation / Elizabeth A. Cummings, Sonia R. Salisbury -- Approaching the adolescent / Alexa L. Bagnell -- Gynecological assessment / Joan B. Wenning -- Assessing the skin / Laura A. Finlayson -- Caring for children with chronic conditions and their families / Richard B. Goldbloom -- Clinical evaluation for possible child abuse / Steven Bellemare -- Assessing the appropriate role for children in health decisions / Nuala P. Kenny, Linda E. Skinner -- Palliative care / Gerri Frager, David LaPierre.
  • "Provides a comprehensive approach to CVJ diseases and their management based on the multidisciplinary cooperation of neurosurgeons, anatomists, neuroradiologists, and neuroanesthesiologists. The main topics highlighted are embryology, normal and abnormal development of the CVJ, including the related vessels, modern radiological contributions to diagnosis, genetic and metabolic factors which may impact on the surgical strategies, the opportunities offered by traditional operative techniques, and the recently introduced minimally invasive and endoscopic surgical modalities. Special emphasis is also placed on the evolution of the principles of surgical treatment as matured during the past decade by experiences in the still open field of pediatric neurosurgery"--publisher description.
  • The Editors and contributors of this book take seriously the statement that For all of the science inherent in the specialty of pediatric critical care medicine, there is still art in providing comfort and solace to our patients and their families. No technology will ever replace the compassion in the touch of a hand or the soothing words of a calm and gentle voice. The four volumes of Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition detail the continued growth and evolution of the pediatric critical care medicine speciality. They reveal the technological innovations in monitoring and information management and gives witness to the rapid evolution and adoption of novel monitoring techniques, such as continuous venous oximetry and near-infrared spectroscopy. They also cover advances in molecular biology that have led to the era of personalized medicine with the ability to individualize treatment to the unique and specific needs of a patient. As such this volume and its three sister titles will be of immense value to all studying and practicing pediatric critical care medicine or those involved in the management of this group of patients.
  • Section I. The Respiratory System in Critical Illness and Injury -- Section II. The Cardiovascular System in Critical Illness and Injury -- Section III. The Central Nervous System in Critical Illness and Injury -- Section IV. The Gastrointestinal System in Critical Illness and Injury -- Section V. The Endocrine System in Critical Illness and Injury -- Section VI. The Renal System in Critical Illness and Injury -- Section VII. The Hematologic System in Critical Illness and Injury -- Section VIII. Oncologic Disorders in the PICU -- Section IX. The Immune System in Critical Illness and Injury.
  • The Editors and contributors of this book take seriously the statement that 'For all of the science inherent in the specialty of pediatric critical care medicine, there is still art in providing comfort and solace to our patients and their families. No technology will ever replace the compassion in the touch of a hand or the soothing words of a calm and gentle voice.' The four volumes of Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition detail the continued growth and evolution of the pediatric critical care medicine speciality. They reveal the technological innovations in monitoring and information management and gives witness to the rapid evolution and adoption of novel monitoring techniques, such as continuous venous oximetry and near-infrared spectroscopy. They also cover advances in molecular biology that have led to the era of personalized medicine with the ability to individualize treatment to the unique and specific needs of a patient. As such this volume and its three sister titles will be of immense value to all studying and practicing pediatric critical care medicine or those involved in the management of this group of patients.
  • The Editors and contributors of this book take seriously the statement that For all of the science inherent in the specialty of pediatric critical care medicine, there is still art in providing comfort and solace to our patients and their families. No technology will ever replace the compassion in the touch of a hand or the soothing words of a calm and gentle voice. The four volumes of Pediatric Critical Care Medicine: Basic Science and Clinical Evidence, 2nd Edition detail the continued growth and evolution of the pediatric critical care medicine speciality. They reveal the technological innovations in monitoring and information management and gives witness to the rapid evolution and adoption of novel monitoring techniques, such as continuous venous oximetry and near-infrared spectroscopy. They also cover advances in molecular biology that have led to the era of personalized medicine with the ability to individualize treatment to the unique and specific needs of a patient. As such this volume and its three sister titles will be of immense value to all studying and practicing pediatric critical care medicine or those involved in the management of this group of patients.
  • Respiratory system -- Cardiovascular system -- Central nervous system -- Infectious diseases -- Hematology and oncology -- Renal system -- Endocrine system -- Nutrition and the gastrointestinal system -- Immunology -- Metabolic disorders -- Pain management -- Pharmacology and toxicology -- Traumatology -- Statistics -- Ethics.
  • Fundamentals of Gas Exchange and the Assessment of Oxygenation and Ventilation / John S. Sullivan and Toah A. Nkromah -- Oxygen Delivery and Oxygen Consumption in Pediatric Critical Care / Juan A. Gutierrez and Andreas A. Theodorou -- Hemodynamics / Scott A. Hagen and Timothy E. Corden -- Regional Circulations / Demetris Yannopoulos and Vinay M. Nadkarni -- Assessment of Cardiovascular Function / Frank A. Maffei -- Overview, Structure and Function of the Nephron / Megan Rashid and George J. Schwartz -- Physiology of Skeletal Muscle and the Neuromuscular Junction / Ellen D. Iannoli and Michael P. Eaton -- Assessment of Neurologic Function / Elizabeth E. Scarlett, Brandi N. Peachey and Jill M. Gotoff -- Endothelial Interactions and Coagulation / Trung C. Nguyen and Joseph A. Carcillo -- The Inflammatory Response / Mark W. Hall -- Genetic Predisposition to Critical Illness in the Pediatric Intensive Care Unit / Neal J. Thomas, Mary K. Dahmer and Michael W. Quasney -- Conventional Mechanical Ventilation / Joseph D. Tobias -- Non-conventional Mechanical Ventilation / Michael D. Dettorre -- Mechanical and Electrical Myocardial Support / Sabrina S. L. Tsao, Kendra M. Ward and Denise M. Goodman -- Renal Replacement Therapies and Other Extracorporeal Therapies / Andrew L. Schwaderer and Marc B. Lande -- Pharmacology / Gretchen L. Brummel and Steven E. Lucking -- Cardiovascular Drug Therapy / Frank A. Maffei -- Sedation and Analgesia / Richard L. Lambert, Lela W. Brink and Frank A. Maffei -- Neuromuscular Blockade / Michael P. Eaton and A. Marika Stone -- Use of Blood Products / Jill M. Cholette and Norma B. Lerner -- Nutrition in Critical Illness / Margaret A. Satchell -- Upper Airway Obstruction / Steven E. Lucking -- Severe Asthma / Neal J. Thomas and Frank A. Maffei -- Acute Respiratory Distress Syndrome / Frank A. Maffei and Neal J. Thomas -- Acute Pulmonary Infections / Karen S. Powers -- Circulatory Failure/Shock / Hector R. Wong -- Sepsis / Angela Lorts, Timothy T. Cornell and Thomas P. Shanley -- Multiple Organ Dysfunction Syndrome / Nikoleta S. Kolovos and Barry P. Markovitz -- Disorders of Cardiac Rhythm / William G. Harmon -- Post-operative Cardiac Care / Surender Rajasekaran and John C. Ring -- Cerebral Resuscitation and Traumatic Brain Injury / Ericka L. Fink, Patrick M. Kochanek and Robert S. B. Clark -- Neurological Diseases in Pediatric Critical Care Medicine / Michael J. Bell and Aditi Sharangpani -- The Approach to the Critically Ill Infant / Frank A. Maffei -- Nosocomial Infections / Elise W. van der Jagt -- Fluid/Electrolyte/Acid-Base Abnormalities / Michael L. Moritz -- Acute Kidney Injury / William S. Varade and Elif Erkan -- Acute Liver Injury and Failure in Children / Richard L. Lambert -- Hematology and Oncology in Critical Illness / Leonardo R. Brandão, Scott C. Howard, Kenneth W. Gow, Surender Rajasekaran and Robert F. Tamburro -- Critical Care Endocrinology / Kecha A. LynShue and Mark A. Sperling -- Metabolic Crises / Paul J. Bellino -- Trauma/Burn / Robert E. Cilley and Eric H. Bradburn -- Toxicology for the Pediatric Intensivist / L. Eugene Daugherty and Frank A. Maffei.
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  • 2011 ClinicalKey
    Provide the latest in superior quality care for critically ill children with the full-color, updated 4th Edition of Fuhrman and Zimmerman's Pediatric Critical Care. In print, and now online, Drs. Bradley P. Fuhrman and Jerry J. Zimmerman use a comprehensive, organ-systems approach to help you manage a full range of disease entities. Get up-to-the-minute knowledge of topics such as acute lung injury, multiple organ dysfunction syndrome, and more. Implement new clinical techniques and diagnostic tests, weigh the varying perspectives of six associate editors with expertise in the field, reference 1,000+ illustrations to aid diagnosis, and keep sharp with online access to board-style review questions. This definitive title will ensure that you consistently deliver the very best intensive care to your pediatric patients. Focus on the development, function, and treatment of a wide range of disease entities with the text's clear, logical, organ-system approach. Keep all members of the pediatric ICU team up to date with coverage of topics particularly relevant to their responsibilities.
  • Designed to accompany Nelson Textbook of Pediatrics and Nelson Essentials of Pediatrics, Pediatric Decision-Making Strategies is a concise, user-friendly reference uses a unique algorithmic approach to facilitate diagnosis, testing, and basic treatment of common pediatric disorders. For any given symptom, an algorithm guides the reader through the appropriate investigative procedures and lab tests to reach definitive diagnoses. An updated format that enhances usability makes this medical reference book a must-have for medical students, residents, and practitioners treating pediatric patients.
  • Pediatric dermatology 2008
    Highly Commended, Dermatology, BMA Awards 2009 Shape the future of dermatology by enhancing your knowledge with this innovative series! This title in the Requisites in Dermatology series is the perfect resource for quick reference and rapid review in pediatric dermatology. It succinctly presents all of the most essential clinical and foundational knowledge you need for certification, recertification or practice. An extremely user-friendly full-color format, replete with full-color clinical photographs and other pertinent illustrations, makes it easy to locate and read up on any topic. Plus, full-text online access lets you consult the book from any computer, download all of the images, watch online lectures, and much more. Expert discussions and abundant full-color photographs guide you through the diagnosis and management of all of the most important and commonly seen pediatric skin conditions. Full-text online access lets you consult the book from any computer, perform quick searches, download all of the illustrations, and clip content for download onto your handheld device. You'll also find online lectures from the chapter authors, self tests, additional downloadable figures, and other exciting materials. A highly user-friendly full-color format and a consistent chapter template guide you effortlessly through all the information you need to know about any topic. Key Points call attention to the most important "takeaways" in each chapter. Abundant algorithms streamline diagnostic and therapeutic decision making. The book's compact size makes it equally convenient for reference in the office, clinic, laboratory, or break room. This title in the 'Requisites in Dermatology' series is the perfect resource for quick reference & rapid review in pediatric dermatology. It succinctly presents all of the most essential clinical & foundational knowledge you need for certification, recertification, or practice.
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    Volume 1 -- Basic science and principles of diagnosis and treatment -- Neonatal and inherited disorders -- Diseases of mucous membranes and appendageal structures -- Volume 2 -- Reaction patterns -- Neoplasms and systemic diseases -- Infections and infestations -- Injury and responses.
  • Introduction to Pediatric Dermatology -- Neonatal Dermatology -- Papulosquamous Eruptions -- Vesiculopustular Eruptions -- Nodules and Tumors -- Disorders of Pigmentation -- Reactive Erythema -- Disorders of the Hair and Nails -- Oral Cavity -- Factitial Dermatoses.
  • Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Development and Neonatology: A Practically Painless Review presents bite-sized chunks of information that can be read and processed rapidly, helping learners to stay active while studying to understand and process new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Development and Neonatology: A Practically Painless Review is a quick and easy way to master these tricky topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up on their skills, medical students and pediatric residents doing rotations, and any busy clinician who wants to learn more about these topics while on the go.
  • This authoritative reference equips you with the essential knowledge to provide comprehensive and effective care to children in an emergency setting. From age-specific diagnoses and chief complaints through developmental considerations and psychosocial issues, this text guides you through the full range of medical and surgical conditions commonly encountered when treating pediatric emergencies. The use of full color throughout, diagnostic algorithms, text boxes, charts, clinical pearls and pitfalls, and other visual features ensure the book will make crucial clinical information easy to find and apply. Tap into expert guidance on all aspects of pediatric emergency medicine, from the physical exam and usual and unusual presentations through to disposition criteria and transfer issues. Access step-by-step guidance on administering critical life support interventions and providing effective diagnostic and therapeutic ambulatory care. Quickly review specific treatment protocols for various emergency settings, including general emergency departments, community hospitals, tertiary care centers, EMS and transport, and triage. Find information fast with or without a known diagnosis, with content organized both by chief complaints and by specific diagnoses. Better understand how problems present differently in infants, children, and adolescents with age-specific diagnoses. Identify and manage the psychosocial issues surrounding pediatric patients, including major depression and suicidality, sexual and physical abuse, child neglect, and violence. Easily absorb key information with the aid of text boxes, algorithms, clinical pearls, and pitfalls. Retrieve information easily with a consistent templated format.
  • Childhood resuscitation -- Neonatal resuscitation -- Respiratory failure -- Shock -- Abdominal pain -- Altered mental status -- Apnea, sudden infant death syndrome, and apparent life-threatening events -- Chest pain -- Cough -- Crying and irritability in the young child -- Diarrhea -- Ear pain -- Fever -- Foreign bodies in children -- Headache -- Hematuria and dysuria -- Hypertension -- Jaundice -- Limp -- Neck masses -- Pediatric rashes -- Red eye -- Scrotal pain -- Sore throat -- Stiff neck -- Stridor -- Syncope -- Vaginal bleeding/discharge -- Vomiting -- Anaphylaxis -- Cardiac emergencies -- Central nervous system emergencies -- Endocrine disorders -- Fluids and electrolytes -- Gastrointestinal emergencies -- Gynecologic emergencies -- Hematologic and oncologic emergencies -- Infectious disease emergencies -- Poisonings -- Psychiatric emergencies -- Respiratory emergencies -- Technology-assisted children-acute care -- Dental/periodontal emergencies -- General surgery emergencies -- Neurosurgical emergencies -- Ophthalmologic emergencies -- Orthopedic emergencies -- Otorhinolaryngology emergencies -- Urologic emergencies -- Abdominal trauma -- Burns and smoke inhalation -- Child abuse -- Dental injuries -- Extremity injuries -- Eye injuries -- Head trauma -- Minor trauma -- Multiple trauma -- Neck and cervical spine trauma -- Pelvic trauma and genitourinary injury -- Pediatric sports injuries -- Thoracic trauma -- Bites and stings -- Drowning -- Electrical and lightning injuries -- Heat-related illness -- Hypothermia -- Chemical and biologic terrorism -- Emergency medical services and prehospital care -- Patient safety in the emergency department -- Risk management and legal issues -- Sedation and analgesia -- Transport medicine.
  • A state-of-the-art and concise guide to the clinical management of pediatric endocrine disorders, the second edition of the highly regarded Pediatric Endocrinology: A Practical Clinical Guide covers the most common and challenging conditions seen by practicing endocrinologists and primary care physicians, including growth, hypothalamic, pituitary, adrenal, thyroid, calcium and bone, and reproductive disorders, as well as metabolic syndromes. This expanded second edition includes new topics being seen more commonly in pediatric endocrinology practices related to obesity and type 2 diabetes mellitus and lipid disorders. Each chapter contains an introductory discussion of the problem, a review of the clinical features that characterize it, the criteria needed to establish a diagnosis, and a comprehensive therapy section delineating the risks and benefits of the best therapeutic options available. Invaluable tables summarize the critical factors in etiology, clinical presentation, diagnosis, and therapeutic dosages. Pediatric Endocrinology: A Practical Clinical Guide, Second Edition, is a comprehensive resource for all clinicians concerned with the myriad endocrinologic disorders seen in children and adolescents.
  • In a single, convenient volume, Pediatric Endocrinology offers complete coverage of all aspects of basic science and clinical practice, ideal for both pediatricians and endocrinologists. Pediatric endocrinology expert Dr. Mark Sperling teams up with world-renowned authors to bring you up to date with the latest key developments in every area of the field, providing invaluable guidance on how your clinical decision making will be affected by today's technological and scientific advances. The user-friendly text is enhanced by all-new online access to the complete contents of the book and more. Determine the best possible course for every patient with easy-to-follow algorithms in every clinical chapter.
  • Pediatric Endourology Techniques, Second Edition enables surgeons to carry out commonly performed minimally invasive pediatric urological procedures. It not only encompasses the majority of commonly performed pediatric endourological procedures in a standardised format, but also newer techniques and procedures that have developed since publication of the first edition. Pediatric Endourology Techniques,Second Editionis a fully illustrated text with accompanying online video content through Springer Extras, which addresses these issues. It is a valuable tool for pediatric urologists as well as pediatric surgeons, general surgeons, adult urologists and those with an interest in minimally invasive surgery.
  • Pediatric ENT 2007
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  • The contributions in this volume cover recent advances and changing concepts on diagnosis and treatment of resistant epilepsy in children. Topics treated are new insights on mechanisms of epileptogenesis in developing brain, multimodality imaging in pediatric intractable epilepsy, pediatric intractable epilepsy syndromes, pediatric temporal lobe epilepsy surgery, critical review of palliative surgical techniques for intractable epilepsy, treatment modalities for intractable epilepsy in hypothalamic hemartomas, contemporary management of epilepsy in tuberous sclerosis.
  • Aerobic fitness: what are we measuring? / N. Armstrong, J.R. Welsman -- Anaerobic fitness tests: what are we measuring? / E. Van Praagh -- Secular changes in pediatric aerobic fitness test performance: the global picture / G.R. Tomkinson, T.S. Olds -- Physical fitness of children and adolescents in the United States: status and secular change / R.M. Malina -- Fitness of Canadian children: range from traditional Inuit to sedentary city dwellers, and assessment of secular changes / R.J. Shephard -- Who are the Eurofittest? / G.R.Tomkinson, T.S. Olds, J. Borms -- Changes in Eurofit test performance of Estonian and Lithuanian children and adolescents (1992-2002) / T. Jürimäe ... [et al.] -- Evolution and variability in fitness test performance of Asian children and adolescents / D.J. Macfarlane, G.R.Tomkinson -- Secular changes in aerobic fitness test performance of Australasian children and adolescents / G.R.Tomkinson, T.S. Olds -- Prevalence, trends, and environmental influences on child and youth physical activity -- J. Salmon, A. Timperio -- Evolution of maximal oxygen uptake in children / T.W. Rowland -- Distributional changes in the performance of Australian children on tests of cardiorespiratory endurance / J. Dollman, T.S. Olds -- Declines in aerobic fitness: are they only due to increasing fatness? / T.S. Olds, K. Ridley, G.R. Tomkinson.
  • As the first book that specifically addresses pediatric formulations in the context of drug development, Pediatric Formulations: A Roadmap covers anatomy and physiology of children as well as the technical state of the art, gives hints about where to find inspiration, and provides a suitable background on the regulatory framework. Existing books on pediatric formulations mainly discuss compounding at the pharmacy. This is not a "how to formulate" textbook for pharmaceutical scientists; the subtitle "A Roadmap" indicates that we are on a path in largely unexplored territory. It is an attempt to equip the reader with necessary information on how to get started with the appropriate mindset. Among medicinal specialties, pediatrics is a young discipline. The potential dangers of medicine were often underestimated in earlier times. Cough suppressants labeled as "suitable for children and adults" a hundred years ago could kill children as they contained opioids. Since then, a complex framework has evolved, with physicians, pharmacists, drug development companies, generic companies, academic scientists, regulatory authorities, reimbursement organizations, patients and children's parents as key players. The position of children in our society has changed dramatically during the last century. Children were protected against clinical trials, yet thanks to clinical trials, many more children with cancer survive today. The development of age-adjusted drug formulations is not only a technical challenge. For new drugs today, there are laws both in the United States and the European Union that compel the research-based pharmaceutical industry to also consider children during drug development. One of the major demands of authorities is the development of age-appropriate formulations.
  • This volume in the Requisites in Pediatrics series offers expert guidance in the assessment and treatment of gastroenterological disorders commonly encountered in clinical practice. It delivers all the information you need in the proven "high-yield" Requisites format - equipping you to master the material quickly. Perfect for quick review and exam preparation, this is one resource you'll consult over and over again! Follows a logical, consistent chapter format to facilitate quick and easy reference. Offers abundant tables that present differential diagnoses, lab values / radiologic studies, treatment / therapy recommendations, and guidance on when to refer to a specialist. Presents thought-provoking clinical scenarios to help you determine the best course of action in situations where there are controversies concerning the standard of care. Features a wealth of illustrations that make details clearer. Includes highlighted boxes that emphasize relevant case studies key points of each section current controversies and other important information.
  • Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Gastroenterology and Nutrition: A Practically Painless Review presents bite-size chunks of information that can be read and processed rapidly, helping learners to stay active while studying and to pick up new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Gastroenterology and Nutrition: A Practically Painless Review is a quick and easy way to master these tricky topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills and any busy clinician who wants to learn more about these topics while on the go.
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  • Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Genetics and Inborn Errors of Metabolism: A Practically Painless Review presents bite-size chunks of information that can be read and processed rapidly, helping learners to stay active while studying and to pick up new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Genetics and Inborn Errors of Metabolism: A Practically Painless Review is a quick and easy way to master these tricky topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills, and any busy clinician who wants to learn more about these topics while on the go.
  • Germ cell tumors are relatively rare compared with other malignancies, and compilations of knowledge that encompass the entire spectrum of the disease are lacking. This textbook, written by the foremost authorities in the field, rectifies the situation by discussing in depth a broad range of topics, including biology, epidemiology, pathology, treatment, and late effects. Bearing in mind that germ cell tumors are most prevalent in the adolescent and young adult age group, causes of disease and treatment approaches in pediatric and adult patients are compared and contrasted. By spanning the entire life course, from prenatal origins of disease through to treatment in adults and late effects of treatment, the editors have produced a book that will be of interest to both pediatric and adult oncologists.
  • The pediatric head and neck cancer patient necessitates a multidisciplinary team of specialists to provide an optimal continuum of care. This A-Z guide provides practical, in-depth information for all medical professionals involved in the evaluation and treatment of these patients. Written in an easy to follow format, each entry contains illustrative figures to aid in pathological and radiographical diagnosis, as well as structured discussion of evaluation and multimodality management. The alphabetical layout eliminates redundancy and allows the busy physician to quickly locate relevant information. Pediatric Head and Neck Tumors is ideal for young physicians as well as attending physicians seeking to expand their knowledgebase to the various subspecialties involved in the multidisciplinary care of their patients.
  • Heart failure--a historical perspective / Abraham M. Rudolph -- Developmental aspects of cardiac performance / David F. Teitel -- Cellular and molecular aspects of myocardial dysfunction / Steven M. Schwartz -- Neurohormonal and immunologic aspects of pediatric heart failure / Reiner Buchhorn -- Genetics of pediatric heart failure / Timothy M. Olson -- Heart failure in the fetus / Lisa K. Hornberger and Masaki Nii -- Heart failure in the neonate / Dana Connolly, Marcelo Auslender, and Michael Artman -- Metabolic causes of pediatric heart failure / Brian D. Hanna -- Cardiomyopathy and myocarditis / J.A. Towbin, Matteo Vatta, and N.E. Bowles -- Inflammatory causes of pediatric heart failure: rheumatic fever, rheumatic heart disease, and Kawasaki disease / Lloyd Y. Tani and Robert E. Shaddy -- Arrhythmias and sudden cardiac death in pediatric heart failure / Michael J. Silka and Jacqueline R. Szmuszkovicz -- Single ventricle lesions / Charles E. Canter -- Right-sided heart failure / Erika Berman Rosenzweig and Robyn J. Barst -- Chronic heart failure in congenital heart disease / Daphne T. Hsu -- Medical management of chronic systolic left ventricular dysfunction in children / Robert E. Shaddy -- Nutritional aspects of pediatric heart failure / Catherine A. Leitch -- Heart failure postpediatric heart transplantation / Mark Boucek -- Cancer treatment-related cardiotoxicities / Svjetlana Tisma-Dupanovic ... [et al.] -- Coronary artery abnormalities / Elfriede Pahl and Stephen G. Pophal -- Heart failure in the postoperative patient / Chitra Ravishankar and Gil Wernovsky -- Ventricular assist devices / Pedro J. del Nido -- Psychosocial aspects of acute and chronic heart failure in children / Kathy Mussatto -- Heart failure in the adult with congenital heart disease (ACHD) / Michael J. Landzberg.
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    Chapter 1. Heart diseases leading to pediatric heart transplantation: cardiomyopathies and congenital heart diseases -- Chapter 2. Recipient evaluation: medical and psychosocial morbidities -- Chapter 3. Management of patients awaiting transplantation: medical, immunologic, and mechanical support -- Chapter 4. Special immunologic issues in pediatric heart transplantation -- Chapter 5. The pediatric heart donor: evaluation of age, size, cause of death, donor heart function, and vitality -- Chapter 6. Surgical techniques in pediatric heart tranplantation -- Chapter 7. Postoperative management: early graft failure, pulmonary hypertension, and initial immunosuppression strategies -- Chapter 8. Survival after pediatric heart transplantation -- Chapter 9. Acute rejection: natural history, risk factors, surveillance, and treatment -- Chapter 10. Infection following pediatric heart transplantation -- Chapter 11. Allograft vasculopathy: detection, risk factors, natural history, and treatment -- Chapter 12. Posttransplant malignancy: risk factors, incidence, diagnosis, treatment -- Chapter 13. Child development posttransplant: growth, intellectual/developmental functioning, and psychosocial functioning -- Chapter 14. Long-term medical morbidities: hypertension , lipids, renal dysfunction, arrhythmias -- Chapter 15. Retransplantation -- Index.
  • Typically, manuals of pediatric hematology-oncology are written by specialists from high-income countries, and usually target an audience with a sub-specialist level of training, often assisted by cutting-edge diagnostic and treatment facilities. However, approximately 80% of new cases of cancer in children appear in mid- and low-income countries. Almost invariably, general practitioners or general pediatricians without special training in oncology will look after children with malignancies who enter the health care system in these countries. The diagnostic facilities are usually limited, as are the treatment options. The survival figures in these conditions are somewhere below 20%, while in high-income countries they are in the range of 80% for many childhood cancers. Pediatric Hematology-Oncology in Countries with Limited Resources is the only book of its kind to provide specific guidance applicable to limited resource settings and builds up from the foundation of general practitioner or general pediatrician competence. Written and edited by leaders in the field, this manual educates physicians on the essential components of the discipline, filtered through the experience of specialists from developing countries, with immediate applicability in the specific healthcare environment in these countries.
  • The field of pediatric hypertension has undergone important changes in the time since the second edition of Pediatric Hypertension published. Much new information on hypertension in the young has become available. Previous chapters have been fully revised and new chapters have been added to cover important topics of recent interest such as consensus recommendations, the prevalence of hypertension in the young due to the obesity epidemic, studies of antihypertensive agents, and ambulatory blood pressure monitoring. Pediatric Hypertension, Third Edition is a comprehensive volume featuring 38 chapters covering the breadth of the current knowledge. It is divided into four sections: Regulation of Blood Pressure in Children; Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology; and Hypertension in Children: Predictors, Risk Factors, and Special Populations; Evaluation and Management of Pediatric Hypertension. Filled with the most up-to-date information, Pediatric Hypertension, Third Edition is an invaluable resource for clinicians and researchers interested in childhood hypertension.
  • Pediatric imaging 2010
    Thieme Book
    "Pediatric radiology is a special field. It is distinguished from most other radiologic disciplines by the fact that it addresses all of the organ systems and imaging modalities. Moreover, it focuses on the most formative and resilient stages of life, from infancy to adolescence. The patients it serves are in some respects the most vulnerable and precious of all. Like other pediatric fields, it is populated by people of special optimism and dedication, and pediatric radiologists typically enjoy relationships of high mutual respect and gratitude with patients, families, and referring health professionals. Studying pediatric radiology is a special privilege, offering opportunities to explore the anatomy, physiology, and pathology of the developing human, and to put to work for our patients some of the most remarkable diagnostic advances in the recent history of medicine. We feel blessed to count ourselves among the long line of physicians who have practiced this craft, and we offer these cases with the hope that they will enrich the quality of care of infants, children, and adolescents for years to come"--Provided by publisher.
  • Pediatric imaging 2008
    Thieme Book
    Lung and mediastinum -- Cardiovascular system -- Neck -- Gastrointestinal tract -- Urogenital tract -- Musculoskeletal system -- Central nervous system.
  • Airway, head and neck / Joehassin Cordero, Bernell K. Dalley, and Gilbert A. Handal -- Allergy, immunology, rheumatology / Robert Mamlok, Kamaljeet Sachdeva -- Pediatric cardiac radiology / Jeffrey A. Becker, Thomas Andrew Bowman, Joon Park -- Child abuse / Gail Lonergan, Suzanne C. Graham, and Elisabeth Goldwater -- Chromosomal abnormalities / Golder Wilson, Vijay S. Tonk, and Amanda Hudkins -- Conscious sedation / James F. Mayhew -- Contrast agents and radiation protection / Daniel Podberesky, William Kubricht, and Romero Sanchez -- Emergency in pediatrics / Veronica Greer, Erin Quattromani -- Pediatric gastrointestinal imaging / Mark Feist ... [et al.] -- Genetic disorders in infants and children / Golder Wilson ... [et al.] -- Pediatric genitourinary imaging / Jonathan S. Vordermark ... [et al.] -- Pediatric hematology, oncology imaging / Askold D. Mosijczuk ... [et al.] -- Pediatric interventional radiology / Melham Ghaleb -- Metabolic and vitamin disorders / Barbara C. Pence and Thomas Andrew Bowman -- Musculoskeletal disorders (osteoradiology) / Robert C. Schutt Jr. ... [et al.] -- Neonatology imaging / C. Antonio Jesurun ... [et al.] -- Pediatric neuroimagingy / William T. O'Brien ... [et al.] -- Orbits / Kelly Mitchell -- Imaging of the respiratory tract in infants and children / Richard Lampe ... [et al.] -- Vascular anomalies / Kimberly Ann Mullinax.
  • Special Considerations in Pediatric Imaging -- Airway -- Chest -- Cardiac -- Gastrointestinal -- Genitourinary -- Musculoskeletal -- Neuro.
  • Often, information in review books can raise as many questions as it answers. This interferes with the study process, because the learner must either look up additional information or skip ahead without truly comprehending what he or she has read. As an alternative, Pediatric Infectious Disease: A Practically Painless Review presents bite-size chunks of information that can be read and processed rapidly, helping learners to stay active while studying and to pick up new information the first time they read it. This book's question and answer format allows for self-testing or study with a partner or a group. The format also facilitates dipping into the book during a few minutes of downtime at the hospital or office. Pediatric Infectious Disease: A Practically Painless Review is a quick and easy way to master tricky infectious disease topics and is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills, and any busy clinician who wants to learn more about this topic while on the go.
  • This new volume in the Requisites in Pediatrics series offers expert advice in the assessment and treatment of infectious diseases in children. An emphasis on common conditions enables you to address the cases you₂re most likely to encounter, and discussions of unusual infections helps you determine when to seek additional information or consultation. It delivers all this information designed in a way that compliments your practice and in the proven ₃high-yield₄ Requisites format--equipping you to master the material quickly. Perfect for quick review, everyday practice, and exam preparation, this is one resource you₂ll consult time and time again! Examines infections in terms of their effects on specific body sites or organs to mirror how diagnoses are often made in real practice. Highlights infections in specific patient populations including newborns, transplant patients, travelers, and children with HIV to equip you to address special scenarios. Discusses immunization and basic infection control in doctors₂ offices and child-care facilities to reduce the risk of the spread of infections. Presents chapters on fevers of unknown origin and febrile syndromes characterized by rashes to prepare you for difficult-to-diagnose cases. Summarizes basic information and vocabulary concerning microorganisms and antimicrobials essential for the interpretation of laboratory reports. Follows a logical, consistent chapter format to facilitate quick and easy reference. Offers practice-proven guidance on differential diagnoses, lab values / radiologic studies, treatment / therapy recommendations, and advice on when to refer to a specialist. Features a wealth of illustrations and tables that make details clearer, and illuminate important information. Includes highlighted boxes that emphasize relevant case studies - key points of each section - current controversies - and other important topics that can affect your practice.
  • Pathogenesis of inflammatory bowel disease / di Nardo, G., Cucchiara, S. -- Epidemiology in pediatric inflammatory bowel disease / Koletzko, S. -- Genetics of inflammatory bowel disease / Cooney, R., Jewell, D. -- Pathology of inflammatory bowel disease in children / Harpaz, N. -- Early-onset inflammatory bowel disease : infant, toddler, and pre-school / Lebenthal, E., Branski, D., Walker-Smith, J.A. -- Radiological and imaging features / Laghi, A. ... [et al.] -- Endoscopic modalities in pediatric inflammatory bowel disease / Venkatesh, K., Thomson, M. -- Approach to clinical diagnosis of inflammatory bowel disease / Bousvaros, A. -- Growth and puberty in inflammatory bowel disease / Savage, M.O., Mark Beattie, R., Sanderson, I.R.S. -- Treatment by enteral nutrition in inflammatory bowel disease / Köglmeier, J., Heuschkel, R. -- Medical therapy for inflammatory bowel disease in children and adolescents / Kappelman, M.D., Rufo, P.A. -- Surgical therapy / McCrudden Erickson, K., Teitelbaum, D.H., Coran, A.G. -- Transition to adult care / Hait, E.J. ... [et al.].
  • Pediatric Inflammatory Bowel Disease, Second Edition provides an essential reference with an emphasis on the unique pediatric issues of IBD. Chapters focus on complications of IBD specific to children and adolescents. Treatment recommendations are based on the latest clinical research available. The textbook also presents sections dedicated to the aspects of participation in clinical research unique to children and adolescents and the complicated yet vital process of successfully transitioning a patient from a pediatric to adult specialist. Controversies in pediatric IBD care such as the off-label use of medications are also covered. The format incorporates multiple tables, graphs, and figures to improve readability and make for an efficient reference for clinicians to use.Thoroughly revised and updated from the first edition, the volumes includes new therapies that are currently being used or tested for treatment of IBD, important areas regarding incidence and prevalence, immunization and response to vaccine administration as well as advancements in our understanding of growth and development with particular to the use of growth hormone therapy. Other new areas covered include important topics of complementary and alternative medicine use in IBD, immunization, and liver disease in IBD. Pediatric Inflammatory Bowel Disease, Second Edition is a valuable resource for pediatric gastroenterologists as well as adult gastroenterologists.
  • Pediatric Anthropometry / Kathleen D. Klinich and Matthew P. Reed -- Epidemiology of Child Motor Vehicle Crash Injuries and Fatalities / Kristy B. Arbogast and Dennis R. Durbin -- Experimental Injury Biomechanics of the Pediatric Extremities and Pelvis / Johan Ivarsson, Masayoshi Okamoto and Yukou Takahashi -- Experimental Injury Biomechanics of the Pediatric Head and Brain / Susan Margulies and Brittany Coats -- Experimental Injury Biomechanics of the Pediatric Neck / Roger W. Nightingale and Jason F. Luck -- Experimental Injury Biomechanics of the Pediatric Thorax and Abdomen / Richard Kent, Johan Ivarsson and Matthew R. Maltese -- Pediatric Computational Models / Bharat K. Soni, Jong-Eun Kim, Yasushi Ito, Christina D. Wagner and King-Hay Yang.
  • The introductory section of the book will highlight the unique elements of pediatric practice that are necessary to provide safe patient care. The remainder of the book will discuss all major vascular and non-vascular PIR procedures. The organization will be procedure specific with secondary area classification.The procedural chapters will be organized using a standard format to make it easier for readers to find information. The chapters will contain introductory descriptions of disease processes, indications for intervention, technical information about the procedures and post procedure care.
  • Shut-down interview and relationships -- Medical interview: the opening phase -- History of present illness -- Concluding phase -- Family -- Well-child visit -- Primary care and child mental health -- Sensitive topics: suicidality, child abuse -- Supporting families expressing grief while giving bad news -- Challenging patients -- Wandering interviews -- Using experiential techniques to teach interviewing skills -- Glossary of interviewing terms.
  • pt. 1. Normal growth and development of children -- pt. 2. The roles of the life care plan team -- pt. 3. Chronic conditions and disability states -- pt. 4. Forensic considerations -- pt. 5. Special issues.
  • Pediatric lymphomas 2007
    Introduction and historical background: pediatric Hodgkin lymphoma -- Biology and pathology of Hodgkin's disease -- Treatment of pediatric Hodgkin lymphoma -- Treatment of relapsed/refractory Hodgkin lymphoma -- Non-Hodgkin's lymphoma: introduction and historical background -- Biology and pathology of pediatric non-Hodgkin lymphoma -- B-cell lymphoma/ Burkitt lymphoma -- Anaplastic large-cell lymphoma -- Precursor B and precursor T-cell lymphoblastic lymphoma -- Cutaneous T-cell lymphomas and rare T-cell non-Hodgkin lymphomas -- Lymphoproliferative disorders related to immunodeficiencies -- Late effects following lymphoma treatment.
  • Pediatric Malignanies: Pathology and Imaging serves as a state-of-the-art reference for understanding the fundamental biology and diagnostic aspects of pediatric tumors. This volume stands apart from other books covering pediatric neoplasia by providing an in-depth analysis of the pathogenetic and diagnostic aspects of the most commonly encountered tumors. The volume covers the new advances in our understanding of the molecular processes underlying a number of pediatric tumors and the novel, sophisticated diagnostic tools that have now become an integral part of practice standards. Pediatric Malignanies: Pathology and Imaging will be of great value for practicing clinicians, oncologists, radiologists, surgeons, pediatricians and pathologists for characterizing and diagnosing childhood tumors.
  • Why Should We Write a Book on Pediatric Metabolic Syndrome? Commentaries from Worldwide Experts / Arthur S. Agatston, Arthur S. Agatston, Arthur S. Agatston, Shari Barkin and Gerald S. Berenson, et al. -- Epidemiology of the Metabolic Syndrome in Youth: A Population-to-Clinical-Based Perspective / Sarah E. Messiah, Kristopher L. Arheart and James D. Wilkinson -- Perinatal Epidemiology of Metabolic Syndrome Risk Factors / Barbara Luke and Mary L. Hediger -- Metabolic Syndrome in Childhood as a Risk Factor for Type 2 Diabetes / Nicola Santoro, Cosimo Giannini and Sonia Caprio -- Effects of Metabolic Syndrome on Atherosclerosis in Childhood / Muhammad Yasir Qureshi, Sarah E. Messiah, Tracie L. Miller and Steven E. Lipshultz -- Metabolic Syndrome and Associated Kidney Disease / Carolyn L. Abitbol and Wacharee Seeherunvong -- Metabolic Syndrome and Related Liver Diseases / Aymin Delgado-Borrego. The Relationship Between Asthma, Sleep Apnea, and Other Respiratory Disorders and Childhood Metabolic Syndrome / Erick Forno and Annabelle Quizon -- The Relationship Between Components of the Metabolic Syndrome and Bone Health / Zeina M. Nabhan and Linda A. DiMeglio -- The Relationship of Childhood Obesity with Cardiomyopathy and Heart Failure / Muhammad Yasir Qureshi, James D. Wilkinson and Steven E. Lipshultz -- Childhood Metabolic Syndrome and Cancer Risk / Stefanie R. Brown and Steven E. Lipshultz -- Neurocognitive and Psychological Correlates of Metabolic Syndrome in Childhood / Anna Maria Patino-Fernandez, Amber Daigre and Alan M. Delamater -- Genomics of Pediatric Metabolic Syndrome / Evadnie Rampersaud and Maria A. Ciliberti -- Physical Activity Assessment and Intervention / Gabriel Somarriba -- Nutritional Evaluation and Intervention / Runa Diwadkar Watkins, Daniela Neri and Tracie L. Miller -- Pharmacological Therapies of Metabolic Syndrome / Adriana Carrillo-Iregui and Carley Gomez-Meade -- Bariatric Surgery to Reverse Metabolic Syndrome in Adolescents / Noor Kassira, Valerie Ann Marks and Nestor de la Cruz-Muñoz -- Moving Clinic- and Community-Based Practice into Policy to Address Child Healthy Weight (and Vice Versa) / Danielle Hollar, T. Lucas Hollar and Michelle A. Lombardo.
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  • Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine presents many of the major, relevant advances in molecular pathology that are occurring in the field of pediatric oncology and will serve as a useful overview for resident and attending physicians as well as scientists interested in understanding the molecular pathology of pediatric cancer in the context of clinical medicine. Chapters are based upon organ systems, and each is written by an expert or pair of experts in their field with subspecialty training and extensive clinical experience. Each chapter describes a variable number of tumors and includes an overview of the classification system and clinicopathological characteristics of each tumor. This is followed by a discussion of the molecular pathology relevant to a specific tumor, including specific molecular markers of the tumors, methods used for diagnosis or clinical management, clinical significance of the markers, and if appropriate, a description or discussion of current activities in translational research or issues that need to be addressed in the future. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine will be of great value to pathologists, oncologists, hematologists, internal medicine and pediatric specialists, as well as pharmaceutical professionals and translational and clinical researchers.
  • v. 1. Sections 1-6 -- v. 2. Sections 7-12.
  • 1. Introduction -- 2. Epidemiology of pediatric brain tumors -- 3. Clinical signs and symptoms of pediatric brain tumors -- 4. Neuro-imaging -- 5. Neuro-surgery -- 6. Low grade glioma -- 7. High grade glioma -- 8. Medulloblastoma/ PNET -- 9. Ependymoma -- 10. Germ cell tumors -- 11. ATRT -- 12. Craniopharyngeoma -- 13. Rare brain tumors (CPP, CPC etc.) -- 14. Infant brain tumors -- 15. Radiotherapy -- 16. Chemotherapy -- 17. Targeted treatment -- 18. Long term sequelae -- 19. Neurocognitive outcome -- 20. Quality of life -- 21. Palliative care -- 22. Cancer syndromes -- 23. Brain tumor stem cells -- 24. Pediatric neurooncology in developing countries -- 25. Neuropathology 26. HDCT/ ASCT -- 27. Developmental neurobiology -- 28. Basic science of pediatric brain tumors.
  • The transcriptome and the hypothalamo-neurohypophyseal system / C. Colin, T. Hindmarch, D. Murphy -- Role of sleep and sleep loss in hormonal release and metabolism / R. Leproult, E. Van Cauter -- Sexual hormones and the brain : an essential alliance for sexual identity and sexual orientation / A. Garcia-Falgueras, D.F. Swaab -- Corticotropin-releasing hormone receptor antagonists : an update / E. Zoumakis, G.P. Chrousos -- New concepts on the control of the onset of puberty / S.R. Ojeda ... [et al.] -- Roles of kisspeptins in the control of hypothalamic-gonadotropic function : focus on sexual differentiation and puberty onset / M. Tena-Sempere -- Role of the growth hormone/insulin-like growth factor 1 axis in neurogenesis / N.D. Åberg -- Sex steroids, growth hormone, leptin, and the pubertal growth spurt / A.D. Rogol -- Endocrine and metabolic actions of ghrelin / V. Gasco ... [et al.] -- Pitfalls in the diagnosis of central adrenal insufficiency in children / R. Kazlauskaite, M. Maghnie -- Central nervous system-acting drugs influencing hypothalamic-pituitary-adrenal axis function / V. Locatelli ... [et al.] -- Genetic factors in the development of pituitary adenomas / S. Vandeva ... [et al.] -- Diagnosis and treatment of Cushing's disease in children / M.O. Savage ... [et al.] -- Prolactinomas in children and adolescents / A. Colao, S. Loche --Pituitary tumors : advances in neuroimaging / G. Morana, M. Maghnie, A. Rossi --Resistin : regulation of food intake, glucose homeostasis, and lipid metabolism / R. Nogueiras ... [et al.] -- Hypothalamic obesity / I. Hochberg, Z. Hochberg --Neuroendocrine consequences of anorexia nervosa in adolescents / M. Misra, A. Klibanski.
  • "Neurogastroenterology is devoted to studying "the interface of all aspects of the digestive system with the different branches of the nervous system." Over the past 15 years, advances in this field have greatly improved our understanding in primary functional and motility disorders in children. Neurogastroenterology has also begun to revolutionize our vision of "organic" diseases like inflammatory bowel disease, obesity, and diabetes, as well as microbial-host interactions. Major advances have also been achieved during these years in the knowledge of mechanisms of development of the enteric nervous system at the molecular level, allowing a better understanding of diseases related to developmental anomalies and opening perspectives to new treatments with stem cells. * Pediatric Neurogastroenterology: Gastrointestinal Motility and Functional Disorders in Children is dedicated to reporting the most accurate and recent knowledge in the field. Written by the world-renown experts, the book covers the field by providing a comprehensive and up-to-date review and practical guide to pediatric gastrointestinal motility and functional disorders for pediatricians, pediatric gastroenterologists, adult gastroenterologists and all professionals involved in the treatment of children with such disorders"--Publisher's description.
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    Techniques and methods in pediatric neuroimaging -- Normal development of the neonatal and infant brain, skull, and spine -- Toxic and metabolic brain disorders -- Brain and spine injuries in infancy and childhood -- Congenital malformations of the brain and skull -- The phakomatoses -- Intracranial, orbital, and neck masses of childhood -- Hydrocephalus -- Congenital anomalies of the spine -- Neoplasms of the spine -- Infections of the nervous system -- Anomalies of cerebral vasculature: diagnostic and endovascular considerations.
  • Techniques and methods in pediatric neuroimaging / Christopher P. Hess and A. James Barkovich -- Normal development of the neonatal and infant brain, skull and, spine / A. James Barkovich and Pratik Mukherjee -- Metabolic, toxic, and inflammatory brain disorders / A. James Barkovich and Zoltan Patay -- Brain and spine injuries in infancy and childhood / Erin Simon Schwartz and Jim Barkovich -- Congenital malformations of the brain and skull / A. James Barkovich and Charles A. Raybaud -- The phakomatoses / Gilbert Vezina and A. James Barkovich -- Intracranial, orbital, and neck masses of childhood / Charles Raybaud and A. James Barkovich -- Hydrocephalus / A. Raybaud and A. James Barkovich -- Congenital anomalies of the spine / Erin Simon Schwartz and A. James Barkovich -- Neoplasms of the spine / A. James Barkovich -- Infections of the developing and mature nervous system / Gary Hedlund and A. James Barkovich -- Anomalies of cerebral vasculature: diagnostic and endovascular considerations / Philip M. Meyers, Van V. Halbach, and A. James Barkovich.
  • Suggestions for history and physical examination -- Headache -- School problems and attention-deficit hyperactivity disorder -- Abnormal movements -- Behavioral and sleep problems -- Seizures, epilepsy, and related disorders -- Dizziness, fainting, and loss of balance -- Delay or regression of motor development associated with low muscle tone -- Autism and language disorders -- Cerebral palsy (static encephalopathy) and related problems -- Abnormalities of cranial size and shape, hydrocephalus, and spinal dysraphism -- Common neurological complications of trauma -- Stroke, acute paraparesis, and other serious disorders of acute and subacute onset -- Other important neurological syndromes.
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  • pt. II ScienceDirect
    Pt. III ScienceDirect
    The child is neither an adult miniature nor an immature human being: at each age, it expresses specific abilities that optimize adaptation to its environment and development of new acquisitions. Diseases in children cover all specialties encountered in adulthood, and neurology involves a particularly large area, ranging from the brain to the striated muscle, the generation and functioning of which require half the genes of the whole genome and a majority of mitochondrial ones. Human being nervous system is sensitive to prenatal aggression, is particularly immature at birth and development may be affected by a whole range of age-dependent disorders distinct from those that occur in adults. Even diseases more often encountered in adulthood than childhood may have specific expression in the developing nervous system. The course of chronic neurological diseases beginning before adolescence remains distinct from that of adult pathology - not only from the cognitive but also motor perspective, right into adulthood, and a whole area is developing for adult neurologists to care for these children with persisting neurological diseases when they become adults. Just as pediatric neurology evolved as an identified specialty as the volume and complexity of data became too much for the general pediatician or the adult neurologist to master, the discipline has now continued to evolve into so many subspecialties, such as epilepsy, neuromuscular disease, stroke, malformations, neonatal neurology, metabolic diseases, etc., that the general pediatric neurologist no longer can reasonably possess in-depth expertise in all areas, particularly in dealing with complex cases. Subspecialty expertise thus is provided to some trainees through fellowship programmes following a general pediatric neurology residency and many of these fellowships include training in research. Since the infectious context, the genetic background and medical practice vary throughout the world, this diversity needs to be represented in a pediatric neurology textbook. Taken together, and although brain malformations (H. Sarnat & P. Curatolo, 2007) and oncology (W. Grisold & R. Soffietti) are covered in detail in other volumes of the same series and therefore only briefly addressed here, these considerations justify the number of volumes, and the number of authors who contributed from all over the world. Experts in the different subspecialties also contributed to design the general framework and contents of the book. Special emphasis is given to the developmental aspect, and normal development is reminded whenever needed - brain, muscle and the immune system. The course of chronic diseases into adulthood and ethical issues specific to the developing nervous system are also addressed. *A volume in the Handbook of Clinical Neurology series, which has an unparalleled reputation as the world's most comprehensive source of information in neurology. *International list of contributors including the leading workers in the field. *Describes the advances which have occurred in clinical neurology and the neurosciences, their impact on the understanding of neurological disorders and on patient care.
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    Dyslexia / Kytja K.S. Voeller -- Sleep disorders in children / Rafael Pelayo ... [et al.] -- Ischemic stroke in childhood / Peter E. Anderson and Gabrielle A. deVeber -- Neuropsychiatric aspects of blindness and severe visual impairment, and deafness and severe hearing loss in children / Bryan H. King, Peter C. Hauser, and Peter K. Isquith -- Movement disorders / Ergun Y. Uc and Robert L. Rodnitzky -- Epilepsy syndromes in childhood / Rochelle Caplan and Erin Lanphier --Prematurity and cerebral palsy / Agnes Whitaker ... [et al.] -- Traumatic brain injury / Sharon Arffa -- Spina bifida and hydrocephalus / Gregory S. Liptak -- Pediatric brain tumors / David L. Kaye and Patricia K. Duffner. Mental retardation / Suzanne T.P.V. Sundheim, Ruth Mize Myers, and Kytja K.S. Voeller -- Genetic syndromes / Chiara Pantaleoni ... [et al.] -- Neuropsychiatric aspects of autism spectrum disorders and childhood-onset schizophrenia / Natacha Akshoomoff -- Attention deficit-hyperactivity disorder / Kytja K.S. Voeller -- Conduct disorder and sociopathy / Markus J.P. Kruesi and Kevin Gray -- Pediatric mood disorders / Robert A. Kowatch ... [et al.] -- Anxiety disorders / Sanjeev Pathak and Bruce D. Perry -- Eating disorders / David C. Jimerson, Barbara E. Wolfe, and Silke Naab -- Substance use disorders / Oscar G. Bukstein and Ralph E. Tarter. Normal development of the nervous system / Harvey B. Sarnat and Laura Flores-Sarnat -- Normal childhood growth and development of intellect, language, temperament, emotion, and social skills / Marilyn Augustyn -- Clinical neuropsychiatric assessment of children and adolescents / Paul D. Larsen -- Neuropsychological and psychoeducational testing / Renée Lajiness-O'Neill and Isabelle Beaulieu -- Anatomic imaging of the developing human brain / Jay N. Giedd -- Functional imaging of the developing human brain / Harry T. Chugani and Csaba Juhász -- Clinical electrophysiology of the developing human brain / Leslie J. Carver and Martha Ann Bell. Pediatric psychopharmacology / Daniel A. Geller, Paul Hammerness, and Thomas Spencer -- Electroconvulsive therapy in pediatric neuropsychiatry / C. Edward Coffey -- Genetic evaluation, counseling, and treatment / Carol E. Anderson -- Psychological and behavioral interventions / Robert T. Ammerman and Mariah E. Coe -- Psychoeducational interventions in pediatric neuropsychiatry / Jeffrey A. Miller ... [et al.] -- Selected legal issues / Peter S. Latham and Patricia H. Latham.
  • v. 1. Brain -- v. 2. Head and neck, spine.
  • Bridging the gap between the pediatric specialist unaccustomed to handling neurovascular pathologies and the neurovascular specialist unaccustomed to treating pediatric patients, this text covers the cutting-edge, multi-modal techniques for managing pediatric neurovascular disease, disorders, and malformations. It contains full descriptions and perspectives on the most advanced surgical, endovascular, and medical treatments for cerebral aneurysms, arteriovenous fistulas, arteriovenous malformations, Galen's vein malformations, moyamoya disease, spinal vascular malformations, pediatric stroke, and more.
  • "This pioneering book, now in its fourth edition, presents the cutting-edge developments in pediatric nuclear medicine. Thoroughly revised and updated, it retains the fundamentals that anchor the book's distinguished reputation and includes the latest advances in PET/CT, SPECT, hybrid imaging, and molecular imaging. Pediatric Nuclear Medicine and Molecular Imaging, Fourth Edition, is an excellent resource for nuclear medicine physicians, diagnostic radiologists, pediatricians, and residents and fellows."--Publisher's website.
  • Introduction / S.T. Treves -- Central nervous system: pt. 1, Brain / S.T. Treves, Harry T. Chugani, Blaise F.D. Bourgeois ; pt. 2, Cerebrospinal fluid / S.T. Treves, Alvin Kuruc -- Thyroid / Stephen A. Huang -- Calculation of administered doses of iodine 131 in the treatment of thyroid disease / Robert E. Zimmerman -- Lungs / S.T. Treves, Alan B. Packard -- Cardiovascular system / S.T. Treves, Elizabeth D. Blume, Laurie Armsby, Jane W. Newburger, Alvin Kuruc -- Gastroesophageal reflux, gastric emptying, esophageal transit, and pulmonary aspiration / Zvi Bar-Sever -- Gastrointestinal bleeding / S.T. Treves, Richard J. Grand -- Liver and spleen / S.T. Treves, A.G. Jones -- Kidneys / S.T. Treves, William E. Harmon, Alan B. Packard, Alvin Kuruc -- Vesicoureteral reflux / S.T. Treves, Ulrich V. Willi -- Calculation of glomerular filtration rate / Robert E. Zimmerman, Karl Mitchell, Royal T. Davis -- Bone / Leonard P. Connolly, Laura A. Drubach, Susan A. Connolly, S.T. Treves -- Pediatric oncology / Hossein Jadvar, Barry L. Shulkin -- Infection and inflammation / Christopher J. Palestro, Charito Love, Maria B. Tomas -- Magnification / Royal T. Davis, Robert E. Zimmerman, S.T. Treves -- Single positron emission computed tomography / Frederic H. Fahey, Beth A. Harkness -- Positron emission tomography / Frederic H. Fahey, Ramsey D. Badawi -- Radiation risk / S. James Adelstein -- Internal dosimetry / Michael G. Stabin.
  • Pediatric nursing caring for children and their families. 3rd ed. 2012
    STAT!Ref, Limited to 7 simultaneous users
    Chapter 1. Overview of pediatric nursing -- Chapter 2. Legal and ethical issues -- Chapter 3. The child in context of the family -- Chapter 4. Community and home health nursing -- Chapter 5. School Nursing -- Chapter 6. Theoretical approaches to the growth and development of children -- Chapter 7. Growth and development of the newborn -- Chapter 8. Growth and development of the infant -- Chapter 9. Growth and development of the toddler -- Chapter 10. Growth and development of the preschooler -- Chapter 11. Growth and development of the school-age child -- Chapter 12. Growth and development of the adolescent -- Chapter 13. Child and family communication -- Chapter 14. Pediatric assessment -- Chapter 15. Infectious Diseases -- Chapter 16. Care of children who are hospitalized -- Chapter 17. Chronic conditions -- Chapter 18. Pain management -- Chapter 19. Medication administration -- Chapter 20. Loss and bereavement -- Chapter 21. Fluid and electrolyte alterations -- Chapter 22. Genitourinary alterations -- Chapter 23. Gastrointestinal alterations -- Chapter 24. Respiratory alterations -- Chapter 25. Cardiovascular alterations -- Chapter 26. Hematological alterations -- Chapter 27. Immunologic alterations -- Chapter 28. Endocrine alterations -- Chapter 29. Cellular alterations -- Chapter 30. Integumentary alterations -- Chapter 31. Sensory alterations -- Chapter 32. Neurological alterations -- Chapter 33. Cognitive alterations -- Chapter 34. Musculoskeletal alterations -- Chapter 35. Psychosocial alterations -- Chapter 36. Child abuse and neglect.
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  • Specific aspects of childhood nutrition -- Nutrition of healthy infants, children, and adolescents -- Nutritional challenges in special conditions and diseases -- Annexes.
  • Global dynamics in childhood obesity: reflections on a life of work in the field -- The neuroendocrine control of energy balance -- Monogenic obesity -- Syndromic obesity -- Polygenic obesity -- Racial differences in childhood obesity : pathogenesis and complications -- Maternal determinants of childhood obesity : weight gain, smoking, and breastfeeding -- Intrauterine growth retardation -- Gestational diabetes -- The role of diet -- Energy expenditure in children : the role of NEAT -- Childhood obesity and the regulation of growth, thyroid function, sexual development, and calcium homeostasis -- Pathogenesis of insulin resistance and glucose intolerance in childhood obesity -- Pathogenesis and management of dyslipidemia in obese children -- Fatty liver disease -- Pathogenesis of hypertension and renal disease in obesity -- Sleep-disordered breathing and sleep duration in childhood obesity -- The long-term metabolic complications of childhood obesity -- Childhood obesity, atherogenesis, and adult cardiovascular disease -- Family-based behavioral interventions -- Exercise and childhood obesity -- School- and community-based interventions -- Pharmacotherapy of childhood obesity and pre-diabetes -- Pathogenesis and management of adiposity and insulin resistance in PCOS : prevention and treatment of the metabolic disease components -- Obesity and metabolic dysfunction in the child with a major behavioral disorder : atypical antipsychotics -- Hypothalamic obesity -- Bariatric surgery in adolescents -- Neuroendocrine and metabolic adaptations in the central nervous system that facilitate weight regain -- The socio-cultural context for obesity prevention and treatment in children and adolescents : influences of ethnicity and gender -- The marketing and distribution of fast food -- Local and national policy-based interventions : to improve children's nutrition.
  • Pediatric oncology 2005
    Acute Leukemia / Michael E. Rytting, Mary S. Choroszy, Demetrios Petropoulos and Ka Wah Chan -- Hodgkin Lymphoma and Non-Hodgkin Lymphoma / Ka Wah Chan, Demetrios Petropoulos, Eric L. Chang and Michael E. Rytting -- Brain Tumors: Diagnosis, Surgery and Radiotherapy, and Supportive Care / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor, Bartlett D. Moore and Donna R. Copeland -- Brain Tumors: Chemotherapy and Investigational Therapy / Joann L. Ater, Jeffrey S. Weinberg, Moshe H. Maor and Demetrios Petropoulos -- Wilms' Tumor / Norman Jaffe and Margaret G. Pearson -- Neuroblastoma / Joann L. Ater and Laura L. Worth -- Soft-Tissue Tumors / R. Beverly Raney, Richard J. Andrassy, Martin Blakely, Tina V. Fanning and Moshe H. Maor, et al. -- Osteosarcoma / Norman Jaffe and Margaret G. Pearson -- Ewing's Sarcoma / Cynthia E. Herzog, Anita Mahajan and Valerae O. Lewis -- Retinoblastoma / Misha Faustina, Cynthia E. Herzog and Dan S. Gombos -- Differentiated Thyroid Cancer / Rena Vassilopoulou-Sellin -- Medullary Thyroid Carcinoma / Robert F. Gagel -- Melanoma / Cynthia E. Herzog, Hafeez Diwan, Merrick I. Ross and Victor G. Prieto -- Novel Therapeutic Approaches / Sima S. Jeha and Laura L. Worth -- Supportive Care: Myelosuppression / Nidra I. Rodriguez Cruz, Renee M. Madden and Craig A. Mullen -- Supportive Care: Symptom Control / Renee M. Madden, Susannah E. Koontz-Webb, Donna S. Zhukovsky and Craig A. Mullen -- Behavioral Medicine in Cancer Care / Donna R. Copeland and Martha A. Askins -- The Adolescent and Young Adult Program / Sima S. Jeha and Martha A. Askins.
  • General Aspects of Childhood Leukemia -- Acute Lymphoblastic Leukemia -- Acute Myeloid Leukemia -- Myelodysplastic Syndrome -- Myeloproliferative Neoplasms -- Non-Hodgkin Lymphoma -- Hodgkin Disease -- Histiocytoses -- Brain Tumors -- Neuroblastoma -- Renal Tumors -- Soft Tissue Sarcomas -- Osteosarcoma -- Ewing Sarcoma Family of Tumors -- Retinoblastoma -- Germ Cell Tumors -- Hepatic Tumors -- Rare Tumors -- Emergencies in Pediatric Oncology -- Oncological Nursing Care -- Psychology and Psychosocial Issues in Children with Cancer.
  • 1 Pediatric: amblyopia -- 2 Pediatric: infectious -- 3 Pediatric: inflammatory -- 4 Pediatric: congenital anomalies -- 5 Pediatric: hereditary retinal disorders -- 6 Pediatric: tumors -- 7 Pediatric: phakomatoses -- 8 Pediatric: craniosynostosis -- 9 Pediatric: other disorders -- 10 Strabismus: esodeviations -- 11 Strabismus: exodeviations -- 12 Strabismus: deviations -- 13 Strabismus: miscellaneous -- 14 Strabismus: nystagmus.
  • Pediatric Ophthalmology and Strabismus is your one-stop source for comprehensive coverage of all the pediatric ophthalmic conditions you are likely to encounter in practice. Extensively updated with expert contributions from leaders in the field and now featuring online instructional videos, this ophthalmology reference delivers all the state-of-the-art guidance you need to effectively diagnose and manage even the most challenging eye diseases and disorders seen in children. Take a holistic approach to patient management that considers the family and ensures optimal doctor-patient relationships.Get a balanced view of etiology, diagnosis, and management, and access unique guidance on the practical problems encountered in real-life clinical cases.Impresses the importance of systemic disease in diagnosis and management.
  • 2008 Springer
    2010 Springer
    [Volume one contents]: -- 1. Development of ocular refraction: lessons from animal experiments -- 2. Preschool vision screening: is it worthwhile? -- 3. Modern treatment of amblyopia -- 4. Retinopathy of prematurity: molecular mechanism of disease -- 5. Screening for retinopathy of prematurity -- 6. Controversies in the management of infantile cataract -- 7. Management of infantile glaucoma -- 8. Pediatric ocular oncology -- 9. Paediatric electrophysiology: a practical approach -- 10. Clinical and molecular genetic aspects of Leber's congenital amaurosis -- 11. Childhood stationary retinal dysfunction syndromes -- 12. Childhood retinal detachment --13. Eye manifestations of intrauterine infections -- 14. Nonaccidental injury. The pediatric ophthalmologist's role. [Volume two contents]: -- pt. 1. Optic nerve -- 1. Optic neuritis and multiple sclerosis -- 2. Ischemic optic neuropathies -- 3. Optic disc drusen -- 4. Inherited optic neuropathies -- ch. 5. Optic nerve tumours -- 6. Traumatic optic neuropathy ... -- pt. 2. Investigations -- 7. Imaging the nerve fiber layer and optic disc -- 8. Functional neuroanatomy of the human visual system ... -- 9. Investigating visual function with multifocal visual evoked potentials -- pt. 3. Retinal disorders -- 10. Autoimmune retinopathies -- 11. Retinal research : application to clinical practice -- pt. 4. Systemic disease -- 12. Chorioretinal lesions in infectious diseases of neuroophthalmic interest -- 13. Giant cell arteritis -- pt. 5. Oculomotility -- 14. Cerebral control of eye movements -- 15. Chronic progressive external ophthalmoplegia ... -- 16. Treatment of specific types of nystagmus -- pt. 6. Rehabilitation -- 17. Rehabilitation in neuroophthamology. [Volume three contents]: -- Epidemiology of Pediatric Strabismus / Amy E. Green-Simms and Brian G. Mohney -- Changes in Strabismus Over Time: The Roles of Vergence Tonus and Muscle Length Adaptation / David L. Guyton -- A Dissociated Pathogenesis for Infantile Esotropia / Michael C. Brodsky -- The Monofixation Syndrome: New Considerations on Pathophysiology / Kyle Arnoldi -- Visual Cortex Mechanisms of Strabismus: Development and Maldevelopment / Lawrence Tychsen -- Neuroanatomical Strabismus / Joseph L. Demer -- Congenital Cranial Dysinnervation Disorders: Facts and Perspectives to Understand Ocular Motility Disorders / Antje Neugebauer and Julia Fricke -- The Value of Screening for Amblyopia Revisited / Jill Carlton and Carolyn Czoski-Murray -- The Brückner Test Revisited / Michael Gräf -- Amblyopia Treatment 2009 / Michael X. Repka -- Best Age for Surgery for Infantile Esotropia: Lessons from the Early vs. Late Infantile Strabismus Surgery Study / H. J. Simonsz, G. H. Kolling and Early vs. Late Infantile Strabismus Surgery Study Group -- Management of Congenital Nystagmus with and without Strabismus / Anil Kumar, Frank A. Proudlock and Irene Gottlob -- Surgical Management of Dissociated Deviations / Susana Gamio -- Surgical Implications of the Superior Oblique Frenulum / Burton J. Kushner and Megumi Iizuka -- Pearls and Pitfalls in Surgical Management of Paralytic Strabismus / Seyhan B. Özkan -- Modern Treatment Concepts in Graves Disease / Anja Eckstein and Joachim Esser.
  • Modified Woodward Procedure for Sprengel's Deformity -- Shoulder External Rotation Tendon Transfers for Brachial Plexus Birth Palsy -- Proximal Humerus Fracture: Reduction and Fixation with Elastic Nail -- Open Reduction and Internal Fixation of Displaced Medial Epicondyle Fracture Using a Screw and Washer -- Radial Head/Neck Fracture: Closed Reduction, Percutaneous Reduction, and Open Reduction -- Lateral Humeral Condyle Fracture: Closed Reduction and Percutaneous Pinning and Open Reduction and Internal Fixation -- Forearm Fractures: Closed Treatment -- Closed Reduction and Pinning of Distal Radius Fractures -- Forearm Fractures: Intramedullary Rodding -- Digital Syndactyly Release -- Innominate Osteotomy -- Chiari Pelvic Osteotomy -- Triple Pelvic Osteotomy -- Single-Incision Supraperiosteal Triple Innominate Osteotomy -- Repair of Proximal Hamstring Avulsion -- Hip Pyarthritis -- Percutaneous in situ Cannulated Screw Fixation of Slipped Capital Femoral Epiphysis -- Bernese Periacetabular Osteotomy -- Anteromedial Approach to a Developmentally Dislocated Hip -- Femur Fracture: Flexible Intramedullary Nailing -- Guided Growth-Hemiepiphysiodesis -- Femoral Lengthening with External Fixation -- Greater Trochanteric Transfer/Relative Femoral Neck Lengthening -- Femur Fracture: Lateral Trochanteric Entry Rigid Nailing -- Submuscular Plating for Pediatric Femur Fractures -- Flexion Osteotomy for Slipped Capital Femoral Epiphysis -- Femur Fracture: Closed Reduction and Spica Cast -- Epiphysiodesis of the Distal Femur/Proximal Tibia-Fibula -- Sofield Osteotomy with Intramedullary Rod Fixation of the Long Bones of the Femur/Tibia -- Discoid Lateral Meniscus -- Patellar Instability: Lateral Release and Medial Plication -- Knee Surgery for Children with Cerebral Palsy Knee Surgery for Children with Cerebral Palsy I: Hamstring Lengthening -- Tibial Spine Fracture: Arthroscopic and Open Reduction and Internal Fixation -- Osteochondritis Dissecans: Arthroscopic Evaluation and Extra-articular Drilling with or without Fixation -- Osteochondritis Dissecans Fixation -- Transphyseal ACL Reconstruction in Skeletally Immature Patients Using Autogenous Hamstring Tendon -- Physeal-Sparing ACL Reconstruction in Skeletally Immature Patients Using Iliotibial Band Technique -- Open Reduction and Internal Fixation of Tibial Tubercle Fractures -- Proximal Tibial Osteotomy for Blount's Disease -- Operative Treatment of Tillaux Fractures of the Ankle -- Tibial Lengthening with Circular External Fixation -- Arthroscopic Management for Juvenile Osteochondritis Dissecans of the Talus -- Triplane Fractures -- Ponseti Method for Idiopathic Clubfoot Deformity -- Resection of Talocalcaneal Tarsal Coalition and Fat Autograft Interposition -- Resection of Calcaneonavicular Coalition and Fat Autograft Interposition -- Chevron Osteotomy for Adolescent Hallux Valgus -- Osteotomies of the Foot for Cavus Deformities -- Flexor Tenotomy for Congenital Curly Toe -- Tibialis Posterior Tendon Transfer -- Split Transfer of the Tibialis Anterior Tendon -- Calcaneal-Cuboid-Cuneiform Osteotomy for the Correction of Valgus Foot Deformities -- Vertical Expandable Prosthetic Titanium Rib (VEPTR) Expansion Thoracoplasty -- Hemivertebra Resection -- Posterior Surgical Treatment for Scheuermann's Kyphosis -- Scoliosis Correction -- Anterior Spinal Instrumentation and Fusion for Lumbar and Thoracolumbar Idiopathic Scoliosis -- Posterior Instrumented Reduction and Fusion for Spondylolisthesis -- Thoracoscopic Release and Instrumentation for Scoliosis.
  • Developmental bone biology -- Imaging approaches for epiphyseal assessment -- Developmental dysplasia of the hip -- Legg-Calve-Perthes Disease -- Coxa Vara in developmental and acquired abnormalities of the femur -- Developmental disorders of the knee -- Deformities due to disorders primarily affecting the epiphyses and metaphyses -- Lower extremity length discrepancies -- Skeletal dysplasias -- Epiphyseal and metaphyseal involvement with metabolic, inflammatory, neoplastic, infectious, and hematologic disorders.
  • Pediatric Orthopedic Imaging is an indispensable reference for pediatric and musculoskeletal radiologists, as well as orthopedic surgeons. It offers in depth analysis of pediatric orthopedic imaging, covering normal and aberrant development as well as both common and unusual pediatric disorders. Chapters on the spine, shoulder, elbow, hand and wrist, hip and pelvis, lower extremity, and foot and ankle address site-specific congenital and acquired lesions. Subsequent chapters cover generalized orthopedic diseases such as neurofibromatosis and osteogenesis imperfecta, infectious processes, neuromuscular diseases, musculoskeletal tumors, trauma, and orthopedic procedures. The chapters review associated epidemiology, clinical presentation and evolution, treatment, and differential diagnoses, with in-depht analysis of imaging characteristics. With more than 1800 images, high-quality MRI, CT, and US examples complement the radiographs of a broad variety of musculoskeletal disorders. The book has been thoroughly researched and clearly written by expert pediatric and musculoskeletal radiologists and extensively reviewed by pediatric orthopedic surgeons. This canonical text addresses conventional and advanced imaging of the complete spectrum of pediatric orthopedic pathology. Pediatric Orthopedic Imaging is an essential reference for all radiologists and orthopedic surgeons whose practice includes pediatrics.
  • Part 1. Trauma Overview -- Polytrauma in the Pediatric Patient / Joshua M. Abzug and Martin J. Herman -- The Mangled Extremity in Children / Sapan D. Gandhi, Joshua M. Abzug and Martin J. Herman -- Compartment Syndrome / Baxter Willis -- Part 2. Spine -- Cervical Spine Injuries in Children / Steven W. Hwang, Per D. Trobisch, Andrew Jea and Amer F. Samdani -- Thoracic and Lumbar Spine Injuries / Hitesh Garg, Joshua Pahys and Patrick J. Cahill -- Part 3. Upper Extremity -- Supracondylar Humerus Fractures / Joshua M. Abzug, Dan A. Zlotolow and Scott H. Kozin -- Upper Extremity Replantation in Children / Joshua M. Abzug, Dan A. Zlotolow and Scott H. Kozin -- Part 4. Lower Extremity -- Pediatric Hip Fractures and Dislocations / James J. McCarthy, Kenneth J. Noonan and Sapan D. Gandhi -- Pediatric Proximal Tibial Fractures with Vascular Compromise / William Hennrikus and Tamara Pylawka -- Open Tibia Fractures in Children and Adolescents / Joseph Rosenblatt and Shannon D. Safier -- Part 5. Infection -- Septic Hip / Peter D. Pizzutillo and Megan Gresh -- Necrotizing Fasciitis / Kevin J. Little and Joshua M. Abzug -- Part 6. Other -- Slipped Capital Femoral Epiphysis / Panagiotis Peter Glavas and B. David Horn.
  • Topics in pediatric orthopedics routinely surface in general pediatrics and primary care medicine, whether on board exams or in clinical practice. Musculoskeletal-related problems are common presenting complaints in any general pediatric or family medicine practice, and in emergency medicine. From birth injuries to musculoskeletal infections and sport-related injuries, many orthopedic conditions and presenting complaints must be addressed by the primary care physician or pediatrician. Pediatric Orthopedics: Handbook for Primary Care Physicians is a concise and targeted handbook filled with all need-to-know conditions, injuries, and diseases, supplemented by over three hundred photos and illustrations. It describes common orthopedic conditions, how to diagnose them, and the indications to either treat these conditions or refer the child to an orthopedist. Readers will learn the natural history of orthopedic diseases and how to differentiate between normal development and abnormal pathological conditions. An easy-to-read bulleted format highlights the most pertinent information for conditions commonly encountered in primary care. In addition, the book provides critical information used to answer musculoskeletal questions on the pediatrics board exam. The two editors come from different specialties (pediatric orthopedics and pediatrics) and present topics in a practical and problem-oriented method. Pediatric Orthopedics: Handbook for Primary Care Physicians is invaluable to all health providers taking care of children, including pediatricians, family medicine physicians, emergency medicine physicians, nurse practitioners, physical therapists, and medical students.
  • Antibiotic therapy for acute otitis, rhinosinusitis, and pharyngotonsillitis -- Pediatric hearing assessment -- Speech, voice and, swallowing assessment -- Methicillin-resistant staphylococcus aureus (MRSA) infections of the head and neck in children -- Polysomnography in children -- Otology -- External otitis -- Diagnosis and management of otitis media -- Tympanostomy tubes and otorrhea -- Chronic disorders of the middle ear and mastoid (tympanic membrane perforations and cholesteatoma) -- Congenital hearing loss (sensorineural and conductive) -- Implantable hearing devices -- Rhinology -- Pediatric facial fractures -- Pediatric epistaxis -- Nasal obstruction in the neonate -- Pediatric allergic nose -- Acute and chronic rhinosinusitis -- Head and neck -- Congenital head and neck masses -- Pediatric stridor -- Inflammatory disorders of the pediatric airway -- Tracheostomy in children -- Cleft lip and palate -- Cough -- Hoarseness in children -- Adenotonsillar disease -- Sleep-disordered breathing (SDB) in children -- Pediatric vascular tumors -- Emergencies in pediatric otolaryngology -- Foreign body management -- Deep space neck infections in the pediatric population -- Complications of acute otitis media -- Complications of sinusitis.
  • The first of its kind, this book describes pediatric palliative care in more than 23 countries. Each region in the world is covered and countries included are both resource poor and rich. Authors are multidisciplinary and regarded nationally and internationally in their field. Clinicians, advocates, policymakers, funders, and researchers will learn how programs were developed and implemented in each country. Authors describe children for whom pediatric palliative care is needed and provided for in their country. When applicable, a brief history of pediatric palliative care is included noting especially policy changes and legislative acts. For example, the chapter on Poland describes how pediatric palliative care grew from the Catholic church into a national movement spearheaded by several health care workers. The Pole national spirit that brought them through a change in political regime has also been a driving force in the pediatric palliative care movement. The chapter on South Africa, for example, illustrates how a resource poor country has been able to leverage philanthropic and government funding to make its dream of having an infrastructure of pediatric palliative care a reality. These are just a few examples of the inspiring stories that are included in this book. Readers from countries who wish to start a pediatric palliative care program, or advance an existing program, will learn valuable lessons from others who have faced similar barriers. Introduction and concluding chapters highlight the strengths and weaknesses of the modern pediatric palliative care movement.
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    section I. Concept of normality -- ch. 1. Describing normality -- ch. 2. General aspects of history taking and interviewing -- section II. Specific aspects of history taking -- ch. 3. Three basic steps in diagnosis -- ch. 4. History taking by systems -- section III. Physical examination -- ch. 5. General physical examination -- ch. 6. Head, neck and sensory organs -- ch. 7. Chest (including heart and lungs) -- ch. 8. Abdomen and genitalia -- ch. 9. Skin -- ch. 10. Musculoskeletal system -- ch. 11. Central nervous system -- section IV. Special examinations -- ch. 12 A. Physical diagnosis of the newborn -- B. The Adolescent -- C. Developmental and behavioral assessment -- D. Physical and sexual abuse.
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    Providing family-centered care in pediatric physical therapy / Elena M. Spearing -- Development -- Motor development in the normal child / Emilie J. Aubert -- Assessment and testing of infant and child development / Susan K. Brenneman and Jan Stephen Tecklin -- Neurological disorders -- The infant at high-risk for developmental delay / Diane Versaw-Barnes and Audrey Wood --The infant and child with cerebral palsy / Jane Styer-Acevedo -- Spina Bifida / Elena Tappit-Emas -- Traumatic injury to the central nervous system: brain injury / Amy Both -- Traumatic and atraumatic spinal cord injury in pediatrics / Heather Atkinson and Elena M. Spearing -- Neuromuscular disorders in childhood: physical therapy intervention / Allan M. Glanzman and Jean M. Flickinger -- Mental retardation: focus on Down Syndrome / Dolores B. Bertoti and Dale E. Smith -- Adaptive equipment and environmental aids for children with disabilities / Emilie J. Aubert -- Musculoskeletal disorders -- Orthopedic management / Meg Stanger -- Traumatic disorders and sports injuries / Joe Molony and Donna Merckel -- Juvenile idiopathic arthritis / Susan E. Klepper -- Other medical/surgical disorders -- Pediatric oncology / Victoria Gocha Marchese -- Rehabilitation of the child with burns / Suzanne F. Migliore -- Cardiac disorders / Heather Brossman -- Pulmonary disorders in infants and children and their physical therapy management / Jan Stephen Tecklin -- Physical therapy in the educational environment / Karen Yundt Lunnen and Rita F. Geddes.
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    v. 1. Trauma.
  • Tools and resources for pediatric practices to develop strategies and action plans, promote collaborative discussions, increase state- and community-level preparedness efforts to best address children's needs in times of emergency, pandemic, outbreak, or disaster.
  • "Pediatric Radiation Oncology is the definitive text and reference on use of radiation therapy for childhood cancer. The fifth edition reviews all significant recent clinical trials--including, for the first time, significant European clinical trials--and provides increased coverage of international and Third World issues. The latest cancer staging guidelines are included. New chapters cover psychosocial aspects of radiotherapy for the child and family and medical management of pain, nausea, nutritional problems, and blood count depression in the child with cancer"--Provided by publisher.
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  • Chest radiographs -- Lateral neck radiographs -- Abdominal radiographs -- Skull radiographs -- Long bone and extremity radiographs -- CT scan review.
  • Pediatric imaging / Johan G. (Hans) Blickman -- Chest / Johan G. (Hans) Blickman and Lya Van Die -- Heart / Rajesh Krishnamurthy and Johan G. (Hans) Blickman -- Gastrointestinal tract / Bruce R. Parker and Johan G. (Hans) Blickman -- Accessory organs of digestion / Bruce R. Parker and Johan G. (Hans) Blickman -- Genitourinary tract / Johan G. (Hans) Blickman and Carla Boetes -- Skeletal system / Johan G. (Hans) Blickman and Geert Vanderschueren -- Brain imaging / Patrick D. Barnes -- Spine imaging / Patrick D. Barnes -- Head and neck imaging / Patrick D. Barnes.
  • Overview of childhood cancer : incidence, survival, and late effects -- Challenges of treating children with radiation therapy -- Leukemia -- Tumors of the central nervous system -- Hodgkin lymphoma -- Neuroblastoma -- Wilms' tumor -- Soft-tissue tumors : (rhabdomyosarcoma and other soft-tissue sarcomas) -- Bone sarcomas (osteosarcoma and Ewing's sarcoma) -- Retinoblastoma.
  • Featuring the work of recognized worldwide experts, this user-friendly text presents the most current scientific information, diagnostic approaches, and management strategies for the care of children with acute and chronic respiratory diseases. A consistent chapter format enables you to rapidly and effortlessly locate the most current protocols on manifestations, etiologies, triggers, approaches to treatment, complications, and preventative strategies. And, a bonus website--new to this edition--features all of the book₂s illustrations and extensive reference lists for each chapter in electronic format for your personal use. Includes guidance on differential diagnosis to help you determine which disease or condition your patient may have. Uses extensive color-coded algorithms to facilitate quick diagnosis, management, and treatment decisions. Organizes material to parallel your clinical decision making process. Provides expert guidance on what diagnostic tests to order for each patient--and how to interpret the results. Presents important ₃take home₄ concepts within each chapter to help you recall clinical pearls. Includes the most need-to-know basic science, focusing on providing clear implications for patient care.
  • Pediatric retina 2011
  • Print Material
  • Print Material
    Adolescent medicine / Mark F. Ditmar -- Behavior and development / Mark F. Ditmar -- Cardiology / Thomas J Starc, Constance J. Hayes, and Allan J. Hordof -- Dermatology / Kimberly D. Morel, Vivian A. Lombillo, and Maria C. Garzon -- Emergency medicine / Joan Bregstien, Cindy Ganis Roskind, and F. Meridith Sonnett -- Endocrinology / Sharon E. Oberfield, Mary Pat Gallagher, and Daniel Esten Hale -- Gastroenterology / Andrew B. Grossman and Chris A. Liacouras -- Genetics / Kwame Anyane-Yeboa -- Hematology / Steven E. McKenzie -- Immunology / Georg A. Hollander and Anders Fasth -- Infectious diseases / Mark F. Ditmar -- Neonatology / Philip Roth -- Nephrology / Robert L. Seigle and Martin A. Nash -- Neurology / Kent R. Kelley -- Oncology / Richard Aplenc, Emily G. Lipsitz, and Peter C. Adamson -- Orthopedics / Benjamin D. Roye -- Pulmonology / Robert W. Wilmott and Bradley A. Becker -- Rheumatology / Carlos D. Rose ... [et al.].
  • Portable and high yield, Pediatric Secrets is perfect for use in clinical rotations, exam prep, or as a handy clinical reference. Drs. Richard A. Polin and Mark F. Ditmar present the essential questions and answers to help you better meet the challenges you face every day, while updated chapters highlight the latest standards in pediatric care. A bestselling volume in the Secret Series, its Q&A format, helpful lists and tables, mnemonics, and informal tone combine to make reference fast, easy, and enjoyable.
  • Part I. Pediatric Sedation Outside the Operating Room -- 1. The History of Sedation -- 2. Sedation Policies, Recommendations and Guidelines Across the Specialties and Continents -- 3. Procedural Sedation: Let's Review the Basics -- 4. The Pre-Sedation Assessment and Implications on Management -- 5. Sedation Scales and Discharge Criteria: How Do They Differ? Which One to Choose? Do They Really Apply to Sedation? -- 6. Physiological Monitoring for Procedural Sedation: The Routine and Beyond -- 7. The Pediatric Airway: Anatomy, Challenges and Solutions -- 8. Pediatric Physiology: How Does It Differ from Adults? -- 9. The Pharmacology and Clinical Application of Sedatives, Analgesics, and Adjuncts -- 10. Sedatives: Effects on Memory and Amnesia -- 11. Pharmacokinetics and Pharmacodynamics in the Pediatric Population -- 12. Billing and Reimbursement for Sedation Services in the United States -- Part II. Sedation Models Delivered by Different Specialties: A Global Voyage -- 13. The Pediatric Hospital Medicine Service: Models, Protocols and Challenges -- 14. The Anesthesia Directed Sedation Service: Models, Protocols and Challenges -- 15. Sedation in the Neonatal Intensive Care Unit: International Practice -- 16. Sedation in the Pediatric Intensive Care Unit: Challenges, Outcomes and Future Strategies in the United States -- 17. Sedation in the Pediatric Intensive Care Unit: Current Practice in Europe -- 18. Sedation for Pediatric Gastrointestinal Procedures -- 19. Sedation in the Emergency Department: A Complex and Multifactorial Challenge -- 20. Sedation of Pediatric Patients for Dental Procedures: The United States, European and South American Experience -- 21. Pediatric Sedation: The European Experience and Approach -- 22. Pediatric Sedation: The South American Approach -- 23. Pediatric Sedation: The Asian Approach ? Current State of Sedation in China -- 24. Pediatric Sedation: The South Pacific Approach -- 25. Pediatric Sedation in the Underdeveloped Third World ? An African Perspective: Models, Protocols and Challenges -- Part III. Safety in Sedation -- 26. Pediatric Sedatives and the Food and Drug Administration (FDA): Challenges, Limitations and Drugs in Development -- 27. Is there Evidence for Long-term Neurocognitive Effects of Sedatives? -- 28. Incidence and Stratification of Adverse Events Associated with Sedation: Is there a Benchmark? -- 29. Medicolegal Risks and Outcomes of Sedation -- 30. Improving the Safety of Pediatric Sedation ? Human Error, Technology and Clinical Microsystems -- Part IV. Sedation into the 22nd Century -- 31. Intravenous Infusions for Sedation: Rationale, State of the Art and Future Trends -- 32. Usage of Complementary and Alternative Medicine in Pediatric Sedation -- 33. Pediatric Research: Designing, Implementing, and Interpreting Strong Trials -- 34. Non-pharmacological Distraction Techniques as Sedation Adjunct -- 35. The Role of Simulation in Safety and Training -- 36. Michael Jackson: Medical Ethics and What Went Wrong -- 37. Ethics and Clinical Aspects of Palliative Sedation in the Terminally Ill Child -- 38. Future of Pediatric Sedation.
  • Pediatric Skin of Color is the first textbook devoted to the issues of pediatric skin of color. In 2052, more than fifty percent of the United States will be of color, and currently seventy percent of the world's population is termed of color. Therefore, this book fills the need for an instructional and educational referebce work regarding these populations. Pediatric Skin of Color discusses the biology and clinical data regarding normal skin, skin conditions exclusive to individuals of color, systemic diseases of individuals of color that have a strong component of skin involvement, and the appearance and demographics of common skin diseases, comparing Caucasian and all skin of color populations. Written for dermatologists and pediatric dermatologists, this text includes data on African American, Asian (Southeast and East), Hispanic/Latino, and Middle Eastern patients, as well as Indigenous populations (i.e. Native Americans, Aborigines).
  • "Pediatric Sonography, Fourth Edition gives you a complete working knowledge of the latest scanning technologies and the clinical applications of ultrasound in pediatric and adolescent patients. Readers will find just the guidance they need to determine the most appropriate imaging method for evaluating a specific clinical problem, conduct the sonographic examination, and interpret the findings. The book shows the sonographic appearance of normal anatomy and disease processes within each organ system and points out technical and interpretive artifacts and errors that can affect evaluations. This edition features more than 1,800 clear, sharp images, including over 300 full-color images throughout. Other highlights include discussions of the uses and limitations of mobile instrumentation and expanded coverage of ultrasound-guided interventional procedures"--Provided by publisher.
  • Pediatric surgery 2006
  • Pediatric surgery 2014
    Written by internationally acclaimed specialists, Pediatric Surgery provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Pediatric Surgery provides a valuable resource for all general surgeons and residents in training. Other healthcare providers will also find this a useful resource.
  • Fluids and Electrolytes -- Nutrition -- Pediatric Anesthesiology -- Procedural Sedation -- Postoperative Neonatal and Pediatric Critical Care -- Disorders of Clotting -- Epidemiology of Trauma -- Injury Prevention and Safety -- Non-accidental Trauma -- Initial Trauma Assessment -- Pathophysiology of Brain Injury -- Algorithm of Treatment for Head Trauma -- Thoracic Trauma -- Abdominal Trauma -- Traumatic Spinal Injury in Children -- Burns -- Pelvic Fractures -- Common Pediatric Fractures -- Necrotizing Enterocolitis -- Congenital Diaphragmatic Hernia -- Esophageal Atresia and Tracheoesophageal Fistula -- Pyloric Stenosis -- Duodenal Atresia -- Intestinal Atresia -- Hirschsprung's Disease -- Malrotation -- Gastroschisis -- Omphalocele -- Imperforate Anus and Cloaca -- Congenital Lung Malformations -- Meconium Plug Syndrome and Meconium Ileus -- Hypospadias -- Disorders of Sexual Differentiation -- Biliary Atresia -- Inguinal Hernia/Hydrocele -- Umbilical Hernia -- Intussusception -- Foreign Body Ingestion and Aspiration -- Branchial Cleft Remnants -- Choledochal Cyst -- Thyroglossal Duct Cyst -- Renal Duplication Anomalies -- Cryptorchidism -- Vesicoureteral Reflux -- Megaureter -- Ureteropelvic Junction Obstruction -- Gastroesophageal Reflux Disease -- Gastrointestinal Bleeding -- Vascular Rings and Slings -- Lymphadenopathy -- Appendicitis -- Hereditary Spherocytosis -- Idiopathic Thrombocytopenic Purpura -- Thrombotic Thrombocytopenic Purpura -- Sickle Cell Anemia -- Gynecomastia -- Pectus Deformity -- Imperforate Hymen -- Inflammatory Bowel Disease -- Multiple Endocrine Neoplasia Syndromes -- Thyroid Nodules -- Breast Nodules -- Adrenal Tumors -- Pancreatitis -- Gallbladder Disease -- Varicocele -- Acute Scrotum -- Pediatric Urolithiasis -- Wilms' Tumor -- Neuroblastoma -- Hepatoblastoma -- Leukemia -- Rhabdomyosarcoma -- Parenteral Access -- Enteral Access -- Chest Tube -- Scoliosis Exposure -- Hydrocephalus: Ventricular Shunts and Endoscopy -- Circumcision -- Patent Ductus Arteriosus Ligation -- Tracheostomy -- Note Templates -- Common Medications -- Vaccination Schedule -- Developmental Milestones.
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  • Pediatric surgery. 7th ed. 2012
    2012 ClinicalKey
    V.1. Pages 1-768 -- v.2. pages 769-1738.
  • The past two decades have witnessed a technological revolution in surgery, leading to the widespread application of minimally invasive techniques. Such techniques have had a profound impact on the diagnosis and therapy of thoracic disorders, including in the pediatric age group. This book is intended as a practical guide to the current approaches in pediatric thoracic surgery. Up-to-date information is provided on the surgical techniques employed for diagnosis and therapy in a wide range of congenital and acquired thoracic pathologies from the prenatal age to adolescence. Among the disorders considered in detail are cystic malformations of the lung, chest wall deformities, diaphragmatic hernias, esophageal anomalies, mediastinal tumors, laryngeal anomalies, and thoracic infections. The authors are distinguished experts in the field from across the world. Pediatric Thoracic Surgery will be of value not only for pediatric thoracic surgeons but also for adult thoracic surgeons, pediatric anesthetists, and pediatric respiratory physicians.
  • Extremity and caval deep venous thrombosis / Madhvi Rajpurkar and Shoshana Revel-Vilk -- Pulmonary embolism / Suzan Williams and Michael Wang -- Cerebral sinovenous thrombosis in children and neonates / Mahendranath Moharir and Gili Kent -- Gastrointestinal and visceral thromboembolism / Courtney A. Lyle and Christoph Male -- Renal and adrenal vein thrombosis / Robert Francis Sidonio Jr. and Leonardo R. Brandao -- Cancer and thrombosis / Uma Athale -- Epidemiology, etiology, and pathophysiology of infection-associated venous thromboembolism in children / Anjali A. Sharathkumar, Neil A. Goldenberg, and Anthony K.C. Chan -- Developmental hemostasis I / Paul Monagle -- Developmental hemostasis II / Marilyn J. Manco-Johnson -- Venous thromboembolism prevention / Ulrike Nowak-Gottl, Gili Kenet, and Neil A. Goldenberg -- Role of global assays in thrombosis and thrombophilia / Meera Chitlur and Mindy Simpson -- Heparin-induced thrombocytopenia and thrombosis syndrome in children / Courtney D. Thornburg -- Severe thrombophilias / Cameron C. Trenor III and Marilyn J. Manco-Johnson -- Thrombolysis / Donald L. Yee, Catherine M. Amlie-Lefond, and Peter H. Lin -- New anticoagulants in children : a review of recent studies and a look to the future / G. Young and Neil A. Goldenberg -- Prevention of VTE in children / Brian R. Branchford and Leslie Raffini -- Arterial ischemic stroke in children / Timothy j. Bernard and Ulrike Nowak-Gottl.
  • With hundreds of question and answer items and bite-sized chunks of information that can be read and processed easily, reviewing for the pediatric board exams - or just brushing up in your spare time - has never been easier. Pediatric Tricky Topics, Volume 1: A Practically Painless Review includes review items in pediatric orthopedics, trauma, environmental medicine, toxicology, rheumatology, and neurology topics, among others. The Q&A format allows for self-testing or study with a partner or a group and is practical and accessible enough to dip into during a few minutes of downtime at the hospital or office, and as such it is suitable for those studying for the pediatric board exam, practicing physicians brushing up their skills, and any busy clinician who wants to learn more about these topics while on the go.
  • Ultrasound plays an important role in the diagnostic imaging of infants and children and has indeed become the workhorse for many conditions. This is attributable both to the avoidance of ionizing radiation and to the unique features displayed on ultrasound in children in almost all body areas. In the future the potential of ultrasound can be expected to increase further owing to new developments such as ultrasound contrast material, three- or four-dimensional ultrasound, and ultrasound elastography. This book systematically covers the use of ultrasound in all organ systems and throughout childhood. After discussion of the basics, including physics, artifacts, and procedural details, decision making regarding the use of ultrasound is elucidated by listing next imaging steps based on recommended imaging algorithms. The indications and prerequisites for a particular examination are documented, and practical tips and tricks are highlighted. The normal, age-dependent ultrasound findings and typical appearances in different pathologies are presented in detail and illustrated by numerous high-quality images. Particular emphasis is placed on those findings that differ from the adult sonographic appearances. In addition to the classic pediatric abdominal applications, detailed consideration is given to neurosonography, echocardiography, chest ultrasound, musculoskeletal and hip ultrasound, Doppler sonography, and interventional ultrasound. The potential role of the most modern techniques in various situations is explained. Pediatric Ultrasound will prove an invaluable source of information and an indispensable aid to decision making and diagnosis for radiology residents, experienced (pediatric) radiologists, sonographers, pediatricians, pediatric surgeons and urologists, and all other physicians who deal with children as a part of their daily practice.
  • Sub-specialization within pediatric orthopedics is growing, in part due to the development of free-standing children's hospitals and the desire by patients and their parents to have "experts" care for them. We are at the forefront of a trend in physicians classifying themselves as pediatric upper extremity surgeons. Numerous pediatric hospitals now have or are recruiting physicians to focus their practice in this area. Historically, these issues were treated by general orthopedic surgeons, adult hand surgeons, pediatric orthopedic surgeons, or plastic surgeons. However, none of these professionals treat the entirety of pediatric upper extremity pathology, and no single reference has focused on the treatment of the pediatric upper extremity as a whole. For example, fractures have typically been written about in pediatric textbooks, while tendon and nerve injuries are covered in adult hand textbooks. This textbook is a comprehensive, illustrated reference that discusses all aspects of the pediatric upper extremity, from embryology and functional development to nerve injuries, trauma, tumors, burns, sports injuries and more.
  • Office urology -- Pediatric urology facts and figures -- Radiographic imaging -- Urinary tract infections -- Voiding dysfunction, urinary incontinence, and urodynamics -- Hematuria: gross and microscopic -- Office procedures -- Genetic diseases and associated urologic manifestations -- Genitalia -- Penis and scrotum: congenital and acquired anomalies -- Hypospadias -- Varicoceles, hernias, and hydroceles -- Testicles: undescended, retractile, and ascended -- Acute scrotum -- Urinary tract -- Hydronephrosis: prenatal and postnatal -- Vesicoureteral reflux -- Urinary tract obstruction -- Tissue engineering and regenerative medicine: current concepts -- Miscellaeous topics -- Adolescent urology -- Laparoscopy in the pediatric population -- Genitourinary tumors -- Genitourinary trauma.
  • While there are Pediatric Urology texts for pediatric urologists and for general urologists, there are none for primary care physicians. This book is written specifically for the primary care physician, the initial contact for the many children with urologic conditions. The text will assist the primary care physician in the recognition of and participation in the care of children with these common problems including both congenital and acquired conditions. Specific chapters are also dedicated to the management of cases that may include medical and/or surgical intervention. The contributing authors of this text were selected for their internationally recognized expertise and straight forward educational styles in the field of Pediatric Urology. Pediatric Urology for the Primary Care Physician will significantly help our primary care colleagues in the evaluation and management of children with genito-urinary problems.
  • Pediatric Urology is an up-to-date, clinical reference that provides detailed descriptions of the best approaches for the functional, biological, and morphological aspects of the urinary tract before and after birth. John G. Gearhart, Richard C. Rink, and Pierre D.E. Mouriquand cover all areas of the field, including pediatric surgery, radiology, nephrology, endocrinology, biochemistry, and obstetrics. Access the latest research through new chapters on tissue engineering, acute scrotum, and more. The appealing new full-color design, streamlined approach, and online access at make this an invaluable resource to pediatric urologists, pediatric surgeons, residents and fellows worldwide. Provides detailed descriptions of the best approaches for the functional, biological, and morphological aspects of the urinary tract before and after birth.
  • pt. 1. Foundations of collaborative care -- pt. 2. Collaboration with pediatricians in specific settings -- pt. 3. Collaboration with pediatricians in treatment of specific disorders -- pt. 4. Future directions in pharmacological collaboration.
  • Many of the systemic autoimmune diseases seen in children are different from those seen in adults making them a special problem for physicians and scientists who care for the affected children and study their diseases. Benefiting both pediatric and adult rheumatologists, as well as physicians from other specialties, this volume covers the latest advances in pathogenesis and clinical management of common conditions seen in pediatric rheumatology practices.
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    General pediatrics -- The newborn infant -- The cardiovascular system -- The respiratory system -- The gastrointestinal tract -- The urinary tract -- The neuromuscular system -- Infectious diseases and immunology -- Hematologic and neoplastic diseases -- Endocrine, metabolic, and genetic disorders -- The adolescent.
  • Think like an experienced clinician and be better prepared for pediatrics practice. Pediatrics: A Competency-Based Companion, by Maureen C. McMahon, MD and Glenn R. Stryjewski, MD, MPH, is designed to teach you to think like an experienced clinician. The only text written in the framework of the Core Competencies developed by the ACGME, its case-based approach illustrates the thought processes that effective practitioners use to approach and evaluate common pediatric presentations. Learning is easy through an intuitive, practical organization...a concise, high-yield presentation...graphs, tables, and other at-a-glance features, such as Professors' Pearls" that provide cases with questions and annotated answers...and a framework that allows you to track your progress and that of your patients in relation to ACGME and AAMC expectations. A convenient pocket-sized format enables you to review the material on the go, and online access via Student Consult includes online extras such as "Integration Links" to bonus content in other Student Consult titles, a Competency Self-Assessment Log, Vertical Reads, and much more. - Publisher.
  • The fully comprehensive book brings together the three main pelvic specialties (Urology, Gynecological Oncology and Colorectal Surgery) into one volume. Patients have been shown to benefit from a multidisciplinary approach since it allows surgeons of different specialties to learn from one another therefore enhancing the treatment for the patient. Pelvic cancer outcomes are poor in low volume centres. These centres account for 80% of the global centres dealing with these cancers. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is a much needed book that can focus training and assist health professionals in their care of patients with pelvic dysfunction. Pelvic Cancer Surgery: Modern Breakthroughs and Future Advances is complete with full color illustrations and schematic diagrams and makes use of key points and stepwise figures for an enhanced learning experience.
  • During recent decades, more than 100 surgical procedures have been proposed to treat pelvic organ prolapse, and surgeons are still searching for the ideal approach. Although generally accepted guidelines and algorithms are still lacking, careful preoperative work-up and patient selection can serve as a sound basis for tailored surgery. In this comprehensive book, leading experts from around the world provide a detailed, up-to-date overview of the diagnostic and surgical approaches employed in patients with prolapse of the middle or posterior pelvic floor compartment. Each surgical technique is explained step by step with the aid of instructive figures. Guidance is also included on the management of surgical complications and of recurrent disease aspects that are too frequently overlooked in the scientific literature. This book will prove essential reading for all who are interested in functional colorectal disorders of the pelvic floor and will represent a unique and invaluable source of knowledge for general surgeons, colorectal surgeons, and urogynecologists, whether in training or practice.
  • Part I. Function and Dysfunction of the Pelvic Floor and Viscera -- Functional Anatomy of the Pelvic Floor and Lower Urinary Tract / Daniele Perucchini and John O. L. DeLancey -- Neural Control of Pelvic Floor Muscles / David B. Vodušek -- The Effects of Pregnancy and Childbirth on the Pelvic Floor / Kaven Baessler and Bernhard Schüssler -- Muscle Function and Ageing / Brenda Russell and Linda Brubaker -- Urinary Incontinence and Voiding Dysfunction / Annette Kuhn and Bernhard Schüssler -- Pelvic Organ Prolapse / Peggy A. Norton -- Anal Incontinence, Constipation, and Obstructed Defecation / Abdul H. Sultan and A. Muti Abulaffi -- Overactive Pelvic Floor Muscles and Related Pain / Wendy F. Bower -- Part II. Evaluation of the Pelvic Floor -- Clinical Evaluation of the Pelvic Floor Muscles / Diane K. Newman and Jo Laycock -- Examination of Patients with Pelvic Organ Prolapse / Ursula M. Peschers -- Urodynamics / Ursula M. Peschers -- Applying Urodynamic Findings to Clinical Practice / Christopher K. Payne -- Anorectal Physiology / David Z. Lubowski and Michael L. Kennedy -- Ultrasound Imaging / Kaven Baessler and Heinz Kölbl -- Magnetic Resonance Imaging / Thomas Treumann, Ralf Tunn and Bernhard Schüssler -- Electrophysiology / Clare J. Fowler and David B. Vodušek -- Outcome Measures in Pelvic Floor Rehabilitation / Kate H. Moore and Emmanuel Karantanis -- Part III. Techniques of Pelvic Floor Rehabilitation and Muscle Training -- Concepts of Neuromuscular Rehabilitation and Pelvic Floor Muscle Training / Jo Laycock -- Exercise, Feedback, and Biofeedback / Pauline E. Chiarelli and Kate H. Moore -- Electrical Stimulation / Wendy F. Bower -- Extracorporeal Magnetic Stimulation / Alastair R. Morris and Kate H. Moore -- Devices / Ingrid Nygaard and Peggy A. Norton -- Alternative Methods to Pelvic Floor Muscle Awareness and Training / Kaven Baessler and Barbara E. Bell -- Part IV. Treatment: Condition-Specific Assessment and Approaches -- Behavioral Treatment / Kathryn L. Burgio -- Stress Urinary Incontinence / Jo Laycock -- Evidence for the Effectiveness of Pelvic Floor Muscle Training in the Treatment and Antenatal Prevention of Female Urinary Incontinence / E. Jean C. Hay-Smith and Kate H. Moore -- Postpartum Management of the Pelvic Floor / Pauline E. Chiarelli -- Role of a Perineal Clinic / Ranee Thakar -- Overactive Bladder / Kathryn L. Burgio, Dudley Robinson and Linda Cardozo -- Sexual Dysfunction and the Overactive Pelvic Floor / Wendy F. Bower -- Anal Incontinence and Evacuation Difficulties / Christine Norton -- Incontinence During Sports and Fitness Activities / Alain P. Bourcier -- Pelvic Organ Prolapse - Pessary Treatment / Jane A. Schulz and Elena Kwon -- Part V. What to Do if Physiotherapy Fails? -- Stress Urinary Incontinence: Choice of Surgery / Stuart L. Stanton -- Genital Prolapse: Surgery for Failed Conservative Treatment / Stuart L. Stanton -- The Anal Sphincter / Klaus E. Matzel, Manuel Besendörfer and Stefanie Kuschel.
  • 1. Principles of Ultrasound and Instrumentation -- 2. Functional Anatomy and Approaches to Imaging of the Pelvic Floor -- 3. Essentials for Setting Up Practice in Clinician Performed Ultrasound -- 4. Ultrasound Imaging in Assessment of the Male Patient with Voiding Dysfunction -- 5. The Female Patient 1- Assessment of Female Voiding Dysfunction -- 6. The Female Patient 2- Pelvic Organ Prolapse -- 7. Imaging of Gynaecologic Organs -- 8. Ultrasound Assessment of the Patient with Fecal Incontinence -- 9. 3D Ultrasound Imaging of the Pelvis.
  • Part 1: Prehospital care, diagnostic tools and resuscitation strategies -- Part 2: Surgical strategies in Penetrating Trauma to Head, Face, and Neck -- Part 3: Surgical Strategies in Penetrating Trauma to the Chest -- Part 4: Surgical Strategies in Penetrating Trauma to the Abdomen and Pelvis -- Part 5: Surgical strategies in Penetrating Trauma and Orthopedic Injuries -- Part 6: Peripheral Arterial Injuries -- Part 7: Other topics.
  • Penile Cancer: Diagnosis and Management provides a comprehensive overview of penile cancer for medical and surgical urologists oncologists, and other healthcare professionals. This book highlights many of the significant advances made in this field, which include a discussion of penile-sparing surgical and radiotherapeutic approaches to select primary penile tumors typically of lower stage and grade as well as advances in our understanding of the epidemiology, risk factors, and pathophysiology of penile cancer. The book also addresses many of the novel diagnostic and therapeutic surgical appro
  • Concise and practical, the Penn Clinical Manual of Urology is an indispensable guide to the daily practice of urology. This one-volume medical reference book presents the key clinical information you need to diagnose and treat urologic disorders quickly and effectively, featuring brief, well-illustrated chapters and an easy-to-read format. Essential for clinical questions and answers, the Penn Clinical Manual of Urology deserves a place on the bookshelf of not only every urologist, but every provider treating urologic problems. Find information quickly and easily with a format that includes clearly presented algorithms, tables, and figures. Effectively review for the boards using the self-assessment questions at the end of each chapter.
  • Introduction -- Economic inclusion -- A closer look at employment -- Political inclusion -- Social inclusion -- Gender, race, ethnicity, and disability -- Conclusion.
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    Clinical and epidemiological foundations / Eric Taylor -- Biological foundations / Sarah Curran -- Diagnosis and assessment / Kapil Sayal -- Psychological assessment / Jody Warner-Rogers -- Medical investigations and tests / Angie Stevens and Gillian Baird -- Making a case formulation : differential diagnosis and recognizing comorbidity / Wai Chen -- Education and advice / Maxine Sinclair -- Pharmacotherapy in ADHD / Paramala J. Santosh -- Behavioural and cognitive approaches / Maxine Sinclair -- ADHD and sleep disorders / Paul Gringras, Adam Jaffe and Stephen Sheldon -- Aspects of medical management / Eric Taylor and Peter Hill -- ADHD in preschool children / Margaret Thompson and Edmund Sonuga-Barke -- Hyperactivity disorders in children with mental retardation / Emily Simonoff -- The clinical assessment and treatment of ADHD in adults / Phillip J. Asherson and J.J. Sandra Kooij.
  • The growing area of peptide and protein therapeutics research is of paramount importance to medical application and advancement. A needed reference for entry level researchers and researchers working in interdisciplinary. Covering cerebral delivery, pulmonary delivery, transdermal delivery, intestinal delivery, ocular delivery, parenteral delivery, and nasal delivery, this resource offers an overview of the main routes in therapeutics. Researchers across biochemistry, pharmaceutical, molecular biology, cell biology, immunology, chemistry and biotechnology fields will find this publication invaluable for peptide and protein laboratory research. Covers current and emerging routes for delivery of therapeutics with a focus on end application Covers Comparative Effectiveness Research Concise, accessible information from active researchers in academia and industry.
  • HPLC analysis and purification of peptides / Colin T. Mant ... [et al.] -- Identification of proteins based on MS/MS spectra and location of posttranslational modifications / Kathryn L. Stone ... [et al.] -- Determination of phosphorylated and O-glycosylated sites by chemical targeting (CTID) at ambient temperature / Gary M. Hathaway -- Synthesis, biosynthesis, and characterization of transmembrane domains of a G protein-coupled receptor / Fred Naider -- Application of topologically constrained mini-proteins as ligands, substrates, and inhibitors / Janelle L. Lauer-Fields ... [et al.] -- Proteolytic profiling of the extracellular matrix degradome / Diane Baronas-Lowell ... [et al.] -- [Beta]-amyloid protein aggregation / Marcus A. Etienne ... [et al.] -- Radiometal-labeled somatostatin analogs for applications in cancer imaging and therapy / Jason S. Lewis and Carolyn J. Anderson -- Cell-penetrating proline-rich peptidomimetics / Josep Farrera-Sinfreu ... [et al.] -- Peptide-mediated targeting of liposomes to tumor cells / Evonne M. Rezler ... [et al.] -- Peptide-mediated delivery of nucleic acids into mammalian cells / Sébastien Deshayes ... [et al.] -- Broth microdilution antibacterial assay of peptides / Laszlo Otvos and Mare Cudic -- Depsipeptide synthesis / Maciej Stawikowski and Predrag Cudic.
  • Peptide growth factors. Part A-B v. 146-147, 1987.
    pt. B ScienceDirect
  • Exemplifying and illustrating recent exciting advances in PNA chemistry, the second edition of Peptide Nucleic Acids: Methods and Protocols serves as a vital complement to the first edition of the book. Since the discovery of peptide nucleic acids, many interesting new derivatives and analogues in terms of nucleic acid recognition specificity and affinity have emerged. Also, as this detailed volume presents, great ingenuity in exploiting the unique properties of PNAs for a wide variety of applications within drug discovery, medical diagnostics, chemical biology and nanotechnology has unfolded. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Peptide Nucleic Acids: Methods and Protocols, Second Editionserves as a source of useful specific methods and protocols as well as a source of inspiration for future developments.
  • PNAs as novel cancer therapeutics / Luca Mologni and Carlo Gambacorti-Passerini -- Medicinal chemistry of plasmid DNA with peptide nucleic acids : a new strategy for gene therapy / Olivier Zelphati ... [et al.] -- Locked nucleic acids (LNA) and medical applications / Henrik Ørum, Andreas Wolter and Lars Kongsbak -- Peptide nucleic acids as agents to modify target gene expression and function / Gan Wang and Peter M. Glazer -- Peptide nucleic acids : cellular delivery and recognition of DNA and RNA targets / David R. Corey -- Receptor-specific targeting with complementary peptide nucleic acids conjugated to peptide analogs and radionuclides / Eric Wickstrom, Mathew L. Thakur and Edward R. Sauter -- Morpholinos and PNAs compared / James E. Summerton -- Chemistry of locked nucleic acids (LNA) : design, synthesis and bio-physical properties / Jesper Wengel ... [et al.] -- Recent applications of RNA interference (RNAi) in mammalian systems / Lisa Scherer and John J. Rossi -- Peptide nucleic acids as epigenetic inhibitors of HIV-1 / Shizuko Sei -- Therapeutic uses of peptide nucleic acids (PNA) in oncology / Nadia Zaffaroni, Raffaella Villa and Marco Folini -- The many faces of PNA / Peter E. Nielsen -- Modulation of nucleic acid information processing by PNAs : potential use in anti-viral therapeutics / Lionel Bastide, Bernard Lebleu and Ian Robbins -- Targeted gene delivery : the role of peptide nucleic acid / Kenneth W. Liang, Feng Liu and Leaf Huang -- Imaging gene expression in the brain with peptide nucleic acid (PNA) antisense radiopharmaceuticals and drug targeting technology / Ruben J. Boado and William M. Pardridge -- The use of PNAs and their derivatives in mitochondrial gene therapy / Paul M. Smith ... [et al.] -- Gene silencing through RNA interference: potential for therapeutics and functional genomics / David O. Azorsa, Spyro Mousses and Natasha J. Caplen -- Transcriptional activation of human CREB gene promoter using bis-PNA (peptide nucleic acid) / Christopher G. Janson ... [et al.].
  • Peptide receptors Part 1-2. 1st ed. pt. 1-2, 2000-2003.
    pt. 2 (2003) ScienceDirect
  • Peptides are used ubiquitously for studies in biology, biochemistry, chemical biology, peptide based medicinal chemistry, and many other areas of research. There is a number of marketed peptide drugs, and the prospects for the development of new peptide drugs are very encouraging. The second edition of Peptide Synthesis and Applications expands upon the previous editions with current, detailed methodologies for peptide synthesis. With new chapters on laboratory protocols for both the specialist and the non-specialist. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Peptide Synthesis and Application, Second Edition seeks to aid scientists in understanding different approaches to the synthesis of peptides by using a broad range of methods and strategies.
  • Peptide-based drug design 2008
    Springer Protocols
    Peptide-based drug design : here and now / Laszlo Otvos, Jr. -- Strategies for the discovery, isolation, and characterization of natural bioactive peptides from the immune system of invertebrates / Philippe Bulet -- Sequence analysis of antimicrobial peptides by tandem mass spectrometry / Christin Stegemann and Ralf Hoffmann -- The spot technique : synthesis and screening of peptide macroarrays on cellulose membranes / Dirk F.H. Winkler and William D. Campbell -- Analysis of A[beta] interactions using ProteinChip technology / Eleni Giannakis ... [et al.] -- NMR in peptide drug development / Jan-Christoph Westermann and David J. Craik -- Molecular dynamics simulations of peptides / Jeffrey Copps, Richard F. Murphy and Sandor Lovas -- Short linear cationic antimicrobial peptides : screening, optimizing, and prediction / Kai Hilpert, Christopher D. Fjell and Artem Cherkasov -- Investigating the mode of action of proline-rich antimicrobial peptides using a genetic approach : a tool to identify new bacterial targets amenable to the design of novel antibiotics / Marco Scocchi ... [et al.] -- Serum stability of peptides / Håvard Jenssen and Stein Ivar Aspmo -- Preparation of glycosylated amino acids suitable for Fmoc solid-phase assembly / Mare Cudic and Gayle D. Burstein -- Synthesis of O-phosphopeptides on solid phase / David Singer and Ralf Hoffmann -- Peptidomimetics : Fmoc solid-phase pseudopeptide synthesis / Predrag Cudic and Maciej Stawikowski -- Synthesis of toll-like receptor-2 targeting lipopeptides as self-adjuvanting vaccines / Brandon Y. Chua, Weiguang Zeng and David C. Jackson -- Synthesis of a multivalent, multiepitope vaccine construct / Laszlo Otvos, Jr. -- Cysteine-containing fusion tag for site-specific conjugation of therapeutic and imaging agents to targeting proteins / Marina V. Backer ... [et al.].
  • The perception-action cycle is the circular flow of information that takes place between the organism and its environment in the course of a sensory-guided sequence of behaviour towards a goal. Each action causes changes in the environment that are analyzed bottom-up through the perceptual hierarchy and lead to the processing of further action, top-down through the executive hierarchy, toward motor effectors. These actions cause new changes that are analyzed and lead to new action, and so the cycle continues. The Perception-action cycle: Models, architectures and hardware book provides focused.
  • This book provides a comprehensive source for all aspects of percutaneous image-guided biopsy. A synthesis of rationale, technique and evidence-based medicine, it offers a clear approach to imaging, devices, procedures and patient care.
  • Percutaneous aortic valve replacement and percutaneous mitral valve repair are emerging alternatives for high-risk patients with severe valve disease. Interventional cardiologists are faced with the challenge represented by this complex procedure. This practical guide specifically deals with a comprehensive knowledge of the techniques and approach to percutaneous treatment of left side cardiac valve disease and discusses the potential complications and expected or potential morbidity from the procedure.
  • Leading authorities on percutaneous tumor ablation come together in this volume to provide a complete overview of everything physicians and other health professionals need to know to successfully implement and administer an image-guided ablation service. After an introduction to the protocols and attendant physics of ablation technology, concise organ-based chapters focus on a wide range of both straightforward and atypical cases to teach readers how to handle the unique clinical and technical challenges associated with percutaneous tumor ablation in different areas of the body. Succinct, step-by-step descriptions complement high-resolution images throughout to illustrate the nuances of each procedure. This must-have clinical reference will develop the technical and clinical tumor ablation skills of every fellow and practicing physician in interventional radiology, oncology, and surgical oncology.
  • "Inside the Sixth Edition of this now-classic reference, you will discover encyclopedic coverage of topics ranging from basic science to sophisticated computer-based radiation therapy treatment planning and supportive care. The book's comprehensive scope and abundantly illustrated format provide you with better understanding of the natural history of cancer, the physical methods of radiation application, the effects of radiation on normal tissues, and the most judicious ways in which you can employ radiation therapy in patient care. Traditionally available as a printed textbook, now it comes with acompletely revamped digital experience, powered by Inkling! NEW to the Sixth Edition ... site-specific chapters include relevant background information on each tumor including epidemiology, pathology, diagnostic work-up, prognostic factors, treatment techniques, applications of surgery and chemotherapy, end results, and more. Over 1,400 full-color illustrationshighlight key concepts in tumor pathogenesis, diagnosis, and targeted radiation therapy. Increased emphasis on new approaches and technologies improve your understanding of three-dimensional treatment planning, intensity-modulated radiotherapy, combined modality therapy, and particle therapy. Greater emphasis on palliative and supportive carereflects the role of radiation treatment in non-curative roles. New editors and contributors let you benefit from their decades of experience. Digital version includes the complete text, index-based search, note sharing, regular content updates integrated into the text, and much more."
  • Often times the symptoms of pericardial disease such as fever, chest pain, and shortness of breath are non-specific, making an accurate diagnosis a challenging task. Now, you can detect and treat pericardial disease in time to save many more patients. This title in the brand-new Clinical Diagnostic Imaging Atlas Series offers you authoritative guidance from a well-known cardiologist and imaging expert about when and how to perform the latest diagnostic imaging tests, interpret the results, and effectively treat the emergency. Detailed discussions of hot topics, full-color illustrations, and a DVD of procedural video clips, animations, and downloadable image libraries help you provide fast, appropriate treatment for each challenging case you face. Offers detailed advice on when and how to screen for the most prevalent but often difficult-to-diagnose pericardial diseases to help you improve care and increase survival rates. Discusses the hottest topics in pericardial disease, including imaging of the pericardium ₅ pericarditis₅ pericardial effusions ₅ pericardial tamponade ₅ pericardial constriction ₅ masses and encasement of the pericardium ₅ pneumopericardium ₅ and more that help you quickly diagnose the non-specific symptoms associated with pericardial disease. Presents 49 fully illustrated case presentations with teaching points that make information easy to understand and digest. Addresses the advantages and limitations of chest radiology, transthoracic and transesophageal echocardiography, cardiac CT, MR, angiography, and nuclear cardiology techniques so you can quickly determine the best imaging approach. Includes supporting evidence and current AHA/ACC guidelines for more accurate interpretations of your imaging findings. Uses a consistent, easy-to-follow chapter format that includes topic overview, an outline of imaging/diagnostic options, and case-based examples to make reference easy. Provides more than 400 full-color illustrations for expert visual guidance. Includes a bonus DVD containing 100 hundred videos of techniques and animations that show you what to look for and how to proceed as well as downloadable image libraries for use in electronic presentations.
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    We provide a broad overview of human brain development with associated malformations and injuries that occur in the period between early embryogenesis and delivery. The aim of this review is to summarize current understanding of the molecular and environmental cues that shape the developing brain. For each developmental stage, we give examples of disorders that arise from genetic and/or environmental insults to illustrate critical points of neurological susceptibility.
  • Perinatal Depression among Spanish-Speaking and Latin American Women:A Global Perspective on Detection and Treatment. As more is known about postpartum depression, the more it is recognized as a global phenomenon. Yet despite the large numbers, information about this condition as experienced by Spanish speaking women and Latinas has not always been easy to come by. Perinatal Depression among Spanish-Speaking and Latin American Women focuses on four diverse Latina populations (Mexico, Chile, Spain, and U.S.) to analyze key similarities and differences within this large and wide-ranging group. This first-of-its-kind reference reviews current research on the topic, including prevalence, screening methods, interventions, and--of particular salience for this population--barriers to care. Findings on psychoeducation, assessment tools, and cognitive-behavioral and other forms of therapy provide important insights into best practices, and continuity of care. And psychosocial, cultural, and linguistic considerations in working with Latinas are described in depth for added clinical usefulness. This landmark volume: Outlines characteristics of Spanish-speaking women and Latinas screened for postpartum depression Introduces the Edinburgh Postnatal Depression Scale, English and Spanish versions, and reviews their use with Latina women Compares postpartum depression and health behaviors in Spanish and Latina immigrant mothers Offers streamlined assessment-to-intervention models Provides two in-depth case studies illustrating cultural factors influencing the treatment of Latinas with perinatal depression Presents an instructive firsthand account of postpartum depression. Between its thorough coverage of the issues and its innovative clinical ideas, Perinatal Depression among Spanish-Speaking and Latin American Women has a wealth of information of interest to researchers and practitioners in maternal and child health, obstetrics/gynecology, mental health, and women's health.
  • Introduction / Melisa M. Adams -- Reproductive Health Issues / Melisa M. Adams -- Maternal Morbidity / Melisa M. Adams -- Maternal Mortality / Melisa M. Adams -- Infant Morbidity / Melisa M. Adams -- The Continuum of Reproductive Loss from Pregnancy Through Infancy / Melisa M. Adams -- Birth Weight, Gestational Duration, and Fetal Growth / Melisa M. Adams -- Conclusion / Melisa M. Adams.
  • "Preface Humans, like all mammals, have an inborn desire to nurture and suckle their young and the act of feeding is important for the bonding between mother and child. The birth of a critically ill preterm infant disrupts this, but for a mother, the use of her milk to feed her infant may be the most tangible role she has in the medical care of her critically sick child. Parents and caregivers see growth and feeding as important milestones first demonstrating increasing stability, then signaling the start of recovery, and finally showing readiness for discharge home. Despite our intuitive and emotional connection with growth, preterm infants grow poorly after birth and very commonly develop ex utero growth restriction (EUGR) or postnatal growth failure. There are many reasons for this including the associated medical conditions of prematurity, but inadequate nutrient intake plays a large part. This results both from technical difficulties in providing adequate nutrition, and from fears about the complications associated with doing so, including metabolic derangements such as hyperglycemia and hyperlipidemia, and diseases such as necrotizing enterocolitis. At the time of hospital discharge, many preterm infants are profoundly growth retarded, and their average weight is as little as 70% of that expected for their peers who were not born prematurely. Preterm infants show variable amounts of catchup growth after discharge, but typically remain smaller than the term-born peers throughout childhood and adolescence. This pattern of early growth restriction followed by variable amounts of catch-up growth has drawn parallels with the in utero growth restricted (IUGR), small-forgestational age, infant"--Provided by publisher.
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    v.1 Reproductive health; v.2 Reproductive risk.
  • Perinatal patient safety and professional liability issues / Kathleen Rice Simpson -- Integrating cultural beliefs and practices when caring for childbearing women and families / Lynn Clark Callister -- Physiologic changes of pregnancy / Susan Tucker Blackburn -- Antenatal care / Mary Lee Barron -- Hypertensive disorders of pregnancy / Judith H. Poole -- Bleeding in pregnancy / Mary Ellen Burke Sosa -- Preterm labor and birth / Nancy Jo Reedy -- Diabetes in pregnancy / Julie M. Daley -- Cardiac disease in pregnancy / Julie Arafeh -- A pulmonary complications in pregnancy / Suzanne McMurtry Baird and Betsy B. Kennedy -- Multiple gestation / Nancy A. Bowers -- Obesity in pregnancy / Mary Ann Maher -- Maternal fetal transport / Judy Wilson-Griffin -- Labor and birth / Kathleen Rice Simpson and Nancy O'Brien-Abel -- Fetal assessment during labor / Audrey Lyndon, Nancy O'Brien Abel, and Kathleen Rice Simpson -- Pain in labor : nonpharmacologic and pharmacologic management / Carol Burke -- Postpartum care / Dotti C. James -- Newborn adaptation to extrauterine life / Debbie Fraser -- Newborn physical assessment / Lyn Vargo -- Newborn nutrition / Jill Janke -- Common neonatal complications / Joan Renaud Smith and Annette Carley.
  • A historical perspective on the psychiatry of motherhood / I. Brockington -- Diagnostic classification of perinatal mood disorders / A. Riecher-Rössler, A. Rohde -- Maternal adversity, vulnerability, and disease / S.G. Matthews, M.J. Meaney -- Behavioral perinatology / P.D. Wadhwa -- Maternal depression: an adverse early environment / A.J. Beach ... [et al.] -- Perinatal infanticide and suicide / M.G. Spinelli -- Relevance of gonadal hormones to perinatal mood and anxiety disorders / A. Ahokas ... [et al.] -- Pharmacotherapy for psychiatric disorders in pregnancy / L.E. Ross ... [et al.] -- Maternal depression in the postpartum period: impact of breast-feeding on treatment planning / Z.N. Stowe, K. Ragan, D.J. Newport -- The use of interpersonal psychotherapy for perinatal mood and anxiety disorders / S. Stuart, M.W. O'Hara -- Group psychotherapy for depression in early stages of motherhood / M. Hofecker-Fallahpour, A. Riecher-Rössler -- Alternative treatment strategies for perinatal depression and anxiety / M. O'Higgins, V. Glover, M. Corral.
  • Subgingival biofilm structure / V. Zijnge, T. Ammann -- Microbial diversity and interactions in subgingival biofilm communities / P.I. Diaz -- Innate cellular responses to the periodontal biofilm / M. Benakanakere, D.F. Kinane -- Neutrophils in periodontal inflammation / D.A. Scott, J.L. Krauss -- Antimicrobial peptides in periodontal innate defense / S.-U. Gorr -- Modern approaches to non-surgical biofilm management / D.A. Apatzidou -- Animal models to study host-bacteria interactions involved in periodontitis / D.T. Graves ... [et al.] -- Antimicrobial advances in treating periodontal diseases / A. Mombelli -- Regenerative periodontal therapy / D.W.K. Kao, J.P. Fiorellini -- Paradigm shift in the pharmacological management of periodontal diseases / H. Hasturk, A. Kantarci, T.E. Van Dyke.
  • Part I: Preoperative Conditions -- General Principles and Practices of Perioperative Medicine -- The Prevalence of Disabling Musculoskeletal Conditions and the Demand for Orthopedic Surgery in the 21st Century -- The Connective Diseases: The Rheumatologist's Perspective -- The Pathophysiologic Events of Total Joint Replacement Surgery -- Part II: Anesthesiological Management -- Anesthesiology in the Orthopedic Patient -- Pediatric Anesthesia for Orthopedic Surgery -- Anesthetic Techniques and Their Clinical Application for Specific Orthopedic Procedures -- The Role of the Post-Anesthesia Care Unit in the Perioperative Care of the Orthopedic Patient -- Postoperative Pain Management in the Orthopedic Setting -- Part III: Medical Management in Specific Clinical Settings -- Perioperative Care of the Orthopedic Patient with Connective Tissue Disease -- Perioperative Care of the Orthopedic Patient with Cardiac Disease -- Perioperative Care of the Orthopedic Patient with Chronic Pulmonary Disease -- Perioperative Care of the Orthopedic Patient with Renal Disease -- Perioperative Care of the Orthopedic Patient with Diabetes Mellitus -- Perioperative Care of the Orthopedic Patient with Gastrointestinal and Liver Issues -- Perioperative Care of the Orthopedic Patient with Neurological Disease -- Perioperative Care of the Orthopedic Patient with Psychiatric Disease -- Part IV: Specific Perioperative Problems in Orthopedic Surgery -- Perioperative Care of the Elderly Orthopedic Patient -- Venous Thromboembolism and Orthopedic Surgery -- Coagulation Disorders and Orthopedic Surgery -- Perioperative Nutrition in the Orthopedic Surgical Patient -- Infection and Perioperative Orthopedic Care -- Risk and Benefits of Bilateral Total Knee Replacement Surgery -- Compartment Syndrome and Orthopedic Surgery: Diagnosis and Management -- Bone Health and Orthopedic Surgery -- Perioperative Care of theComplex Spine and Scoliosis SurgeryPatient -- Management of Blood Products in Orthopedic Surgery -- Part V: Role of Allied Services -- Professional Nursing Practice in the Orthopedic Care Setting -- The Approach to Physical Therapy Following Orthopedic Reconstructive Surgery -- Quality Improvement in the Perioperative Orthopedic Setting -- Introduction of Clinical Pathways in Orthopedic Surgical Care: The Experience of the Hospital for Special Surgery -- Ethical Considerations in Perioperative Orthopedic Medicine.
  • This book is written by experts in ultrasonography, it follows an evidence-based-medicine approach, exploring the latest ultrasound applications for regional anesthesia and pain relief procedures, as well as diagnostic and critical care medicine. A companion DVD shows you how to perform the techniques discussed in the text.
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  • All anesthesiologists are confronted with patients who show bleeding disorders, whether congenital, acquired, or pharmacologically induced. Although many studies, meta-analyses, guidelines, and textbooks have been published on the subject, they mostly cover specific aspects or require a thorough knowledge of hemostasis. The goal of this book is to provide the anesthetist with an overview of hemostasis and the mechanisms underlying bleeding and coagulation in general and to assist in the understanding of specific coagulation disorders as they may occur in the various anesthetic subspecialties. It is hoped that, through the provision of practical information and tools, the book will help residents and trained anesthetists to manage one of the most frustrating challenges that they face: the bleeding patient. A full understanding of coagulation requires a lifelong career, and this book is not intended to replace the consulting hematologist, whose expert opinion should always be sought. The available procoagulant blood products and drugs all have potentially dangerous side-effects; furthermore, in bleeding disorders pitfalls are frequent and a misdiagnosis can have potentially catastrophic consequences. The aim of the editors is thus instead to enhance the collaboration between the disciplines of Anesthesiology and Hematology.
  • The kidneys participate in all vital processes of the body to maintain overall homeostasis and health. When kidneys are injured during surgical interventions, metabolic and hemodynamic control is disrupted, leading to dysfunction associated with greater mortality, length of hospital stay, and cost. Peri-operative Kidney Injury presents the epidemiology, risk factors, diagnosis, treatment, and outcomes associated with kidney injury during the peri-operative period. Concepts and principles of care to prevent kidney complications during surgical procedures are provided to equip health care professionals along with strategies to manage acute kidney injury and associated challenges when they occur. Chapters detail diverse surgical settings, ranging from the more common, such as abdominal, cardiac, and vascular surgeries, to the intricately complex, including the use of the left ventricular assist device and organ transplants. This practical and comprehensive text blends the evidence-based standards of care with cutting edge advances in the field, while also providing the reader with a peek into innovations on the horizon.
  • Role of the Medical Consultant -- Preoperative Testing -- Perioperative Medication Management -- Perioperative Management of Anticoagulation -- Venous Thromboembolism Prophylaxis -- Prevention of Infective Endocarditis (Bacterial Endocarditis Prophylaxis) -- Surgical Site Infection Prophylaxis -- Anesthesiology for the Nonanesthesiologist -- Abdominal Surgery -- Thoracic Surgery -- Vascular Surgery -- Orthopedic Surgery -- Neurosurgery -- Gynecologic Surgery -- Urologic Surgery -- Bariatric Surgery -- Ophthalmic Surgery -- Otolaryngologic Procedures -- Electroconvulsive Therapy -- Cardiac Disease -- Pulmonary Disease -- Endocrine Disease -- Hematologic Disease -- Cancer -- HIV -- Chronic Kidney Disease -- GI Disease -- Rheumatic Disease -- Neurological Disease -- Psychiatric Conditions -- Substance Abuse -- The Pregnant Surgical Patient -- Postoperative Fever -- Postoperative Hypertension/Hypotension -- Postoperative Arrhythmias -- Perioperative Chest Pain/Dyspnea -- Postoperative Pulmonary Complications -- Postoperative Venous Thromboembolism (DVT and PE) -- Postoperative Fluid, Electrolyte, and Acid/Base Disorders -- Postoperative Renal Failure -- Anemia and Bleeding -- Postoperative Jaundice -- Postoperative Stroke and Seizures -- Postoperative Delirium -- Pain Management.
  • This resource presents best management approaches for achieving optimal perioperative outcomes. It reviews the potential risks to all major organ systems by examining the incidence and significance of organ dysfunction, assessing the etiology of particular organ dysfunctions, defining the preoperative and intraoperative risk factors and offering perioperative protection strategies to minimize potential complications. A consistent chapter format combined with color-coded algorithms, summary tables and boxes enable you to quickly locate specific guidance.
  • Principles and the normal heart -- Getting started with echocardiography: the twenty standard views -- Principles and physics: principles of ultrasound -- Principles and physics: principles of Doppler ultrasound -- Principles and physics: equations to remember (the Bernoulli equation, velocity-time integrals, and the continuity equation) -- Principles and physics: transducer characteristics -- Principles and physics: imaging artifacts and pitfalls -- Normal anatomy and flow during the complete examination: components of the complete examination -- Normal anatomy and flow during the complete examination: epiaortic imaging -- Normal anatomy and flow during the complete examination: three-dimensional views: replicating the surgeon's view -- Normal anatomy and flow during the complete examination: extracardiac anatomy -- Quantitative and semiquantitative echocardiography: dimensions and flows -- Quantitative and semiquantitative echocardiography: ventricular and valvular physiology -- Understanding how transesophageal echocardiography demonstrates cardiovascular pathology -- Myocardial ischemia and aortic atherosclerosis -- Aortic valve anatomy and embryology -- Mitral valvular disease -- Tricuspid valvular disease -- Pulmonic valvular disease -- Cardiomyopathies -- Aneurysms and dissections -- Endocarditis -- Imaging of cardiac tumors and solid and gaseous materials -- Intracardiac devices, catheters, and cannulas -- Echocardiographic evaluation of pericardial disease -- Adult congenital heart disease -- Pulmonary hypertension -- Recent advances -- Maintaining quality of perioperative echocardiography -- Indications for transesophageal echocardiography -- Complications of transesophageal echocardiography -- Equipment, infection control, and safety -- Oversight and administration -- Training and certification for transesophageal echocardiography -- Medical insurance claims, compliance, and reimbursement for anesthesiology -- Regulatory, legal, and liability issues pertaining to transesophageal echocardiography.
  • A history of transfusion / Bruce Spiess and Richard K. Spence -- The contemporary economics of transfusion / Timothy J. Hannon and Kathy Paulson Gjerde -- Blood supplies now and in the future / Mike Fitzpatrick -- Medical ethics, transfusion and the standard of practice / Kenneth Kipnis -- Oxygen transport monitoring: the basis for developing transfusion triggers / Kevin Ward and Ivo Torres Filho -- Physiology of anemia and red blood cell transfusion / Howard Corwin and Paul C. Høbert -- Physiology of hemostasis / Wayne L. Chandler -- Platelet physiology: cellular and protein interactions / Christine S. Rinder -- Iron metabolism and erythopoiesis / Kenneth R. Bridges -- New concepts in oxygen transport / Aryeh Shander, Tanuja S. Rijhwani, and Carmine Gianatiempo -- Infectious risks of transfusion / Eberhard W. Fiebig and Michael P. Busch -- Immunomodulation by transfusion / Neil Blumberg and Joanna M. Heal -- Serious acute transfusion reactions / Ira A. Shulman and Aryeh Shander -- A surgeon's guide to blood banking and transfusion medicine / Kimberly W. Sanford and Susan D. Roseff -- Blood storage / Ian Chin-Yee and Richard K. Spence -- Quality control and hospital blood utilization / Kathy Walsh-Kaminsky -- Preoperative autologous donation / F. Mercuriali, G. Inghilleri, and Richard K. Spence -- Erythropoetin therapy / Lawrence T. Goodnough -- Hemoglobin based oxygen carriers / Gregory M.T. Hare and C. David Mazer -- Perfluorocarbon emulsions: artificial gas transport media / Bruce D. Spiess -- Initial resuscitation of the hemorrhaging patient / Richard P. Dutton -- Transfusion and coagulation therapy in trauma and burns / James K. Wright, Harriet W. Hopf, and Lewis J. Kaplan -- Acute gastrointestinal bleeding and transfusion management / Richard Peterson, Patricia Parce, and Richard K. Spence -- Coagulation in trauma: dilution and massive transfusion / Richard K. Spence and Anthony Martinez -- Coagulation product use in the perioperative period / Richard K. Spence and Aryeh Shander -- Coagulation monitoring in the perioperative period / Linda Shore-Lesserson and Bruce D. Spiess -- Surgery in patients with acquired platelet and clotting deficiencies / Richard K. Spence and Andrew Green -- Surgery in patients with congenital clotting deficiencies / Richard K. Spence and Andrew Green -- Perioperative implications of anticoagulant and antiplatelet therapy / Jeffrey A. Green -- Pharmacological approaches to prevent or decrease bleeding in surgical patients / Jerrold H. Levy -- Fibrin glue and platelet gel / Bruce Searles and Cody Trowbridge -- Anesthesia techniques in blood conservation / Aryeh Shander and Tanuja Rijhwani -- Perioperative red cell salvage and autotransfusion / Jonathan H. Waters -- Intraoperative acute nomovolemic hemodilution / Aryeh Shander and Tanuja S. Rijhwani -- Hypothermia and hemorrhage / Richard P. Dutton -- Surgery in patients with red cell disorders: sickle hemoglobinopathies, polycythemia, and autoimmune hemolytic anemia / Imoigele P. Aisiku -- Surgery in the Jehovah's Witness / Richard K. Spence ... [et al.] -- Coagulation, transfusion, and cardiac surgery / Simon S. Body and David S. Morse -- Blood loss and transfusion alternatives in vascular surgery / Richard K. Spence -- Solid organ transplantation / Nicolas Jabbour, S. Ram Kumar, and Singh Gagandeep -- Blood use in orthopedic surgery / E. Michael Keating and John B. Meding -- Blood management in obstetrics and gynecology / Arnold J. Friedman -- Hemorrhage in pediatric patients / Thomas V. Whalen -- Transfusion in oncologic surgery / Patricia A. Ford and Jason Mastoris -- Transfusion and coagulation dysfunction in neurosurgery / Robert S. Graham and J. Chris Zacko -- Transfusion and outcome / Bruce D. Spiess, Richard K. Spence, and Aryeh Shander -- The transfusion decision / Bruce D. Spiess, Richard B. Counts, and Steven A. Gould -- Undertransfusion / Richard K. Spence and Aryeh Shander -- A philosophy of blood management / Aryeh Shander, Richard K. Spence, and Bruce D. Spiess.
  • Normal TEE Views -- Doppler and Hemodynamics -- Ventricles -- Native Valves -- Prosthetic Valves Transcatheter Valves and Valve Repairs -- Aorta -- Congenital Heart Disease -- Variants, Foreign Material, Masses and Endocarditis -- Ventricular Assist Devices and Heart Transplant -- Hypertrophic Obstructive Cardiomyopathy and Diastolic Dysfunction -- Pericardium.
  • Peripheral and cerebrovascular disease / Vijay Nambi and Deepak L. Bhatt -- Lower extremity intervention / Samir K. Shah and Daniel G. Clair -- Critical limb ischemia / Raghotham Patlola and Craig Walker -- Renal and mesenteric intervention / Ramy A. Badawi and Christopher J. White -- Subclavian and upper extremity interventions / Khung Keong Yeo and John R. Laird -- Carotid and vertebral intervention / Douglas E. Drachman, Nicholas J. Ruggiero II and Kenneth Rosenfield -- Intracranial intervention / Muhammad Shazam Hussain and Rishi Gupta -- Abdominal and thoracic aortic aneurysms / Aravinda Nanjundappa ... [et al.] -- Venous intervention / Andrew B. McCann and Robert M. Schainfeld.
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  • Evolution of endovascular therapy: diagnostics and therapeutics -- Pathophysiology of vascular disease -- Training and credentialing in vascular and endovascular surgery -- Assessment of vascular patients and indications for therapy -- Anesthesia techniques for endovascular surgery -- Intraprocedural monitoring for endovascular procedures -- Safety considerations for endovascular surgery -- Endovascular intervention suite design -- Angioscopy: instrumentation, techniques, and applications -- Duplex-guided balloon angioplasty from the carotid to the plantar arteries -- Intravascular ultrasound imaging -- Biomaterials: considerations for endovascular devices -- Ancillary endovascular equipment: catheters, guidewires, and procedural considerations -- Balloon angioplasty -- Endovascular intervention for lower extremity deep venous thrombosis -- Remote femoral and iliac artery endarterectomy -- Intravascular stents -- Intravascular laser technologies -- Endovascular devices for abdominal aortic aneurysms -- Endovascular devices for thoracic aortic aneurysms -- Critical limb ischemia -- Renal stents -- Inferior vena cava filters: the impact of endovascular technology -- Carotid stenting -- Neuroendovascular interventions -- The current status of hybrid repair of thoracoabdominal aortic aneurysms -- Laparoscopic aortic surgery -- Endovenous surgery -- Thoracic outlet syndrome: endoscopic transaxillary first rib approach: 23 years experience (1985-2008) -- Prevention of lesion recurrence in endovascular devices -- Management of the percutaneous puncture site -- Endovascular practice in Asia-Pacific -- Future imaging and guidance for endovascular procedures.
  • The new edition of this practical multimedia resource shows you exactly how to perform successfully a full range of peripheral nerve block techniques. Over four hundred illustrations, the majority of which are in colour, the relevant surface anatomy, the internal anatomy, the ultrasonographic anatomy to vividly depict correct needle placement in real patients.
  • Peripheral nerve disorders 2013
    "Disorders of the peripheral nervous system (PNS) are the cause of prominent neurological symptoms including weakness, sensory loss, pain and autonomic dysfunction associated with deficits, morbidity and mortality. These disorders may be primary hereditary or cryptogenic neurologic disorders confined to the PNS or part of the pathology of both the central nervous system and the PNS. Most PNS disorders are secondary to other system disorders and may be responsive to treatment of the primary disease. Important advances have been obtained in several areas including molecular genetics, biochemistry, immunology, morphology and physiology that have enhanced our understanding of the causes and consequences of damage to peripheral nerve. Understanding of both these groups of PNS diseases has greatly expanded over recent years and has led to important advances of treatment both to protect and to repair damages of peripheral nerve. This volume provides an overview of the state-of-the-art of examination, diagnosis and treatment of these very diverse disorders and will be of interest to both the research and clinical neuroscience and neurology communities"--Publisher's description.
  • The Peripheral Nervous System: Anatomy and Function -- Reactions to Injury -- Regeneration and Recovery of Function -- Clinical Aspects of Nerve Injury -- Operating on Peripheral Nerves.
  • History of peripheral nerve stimulation / Slavin, K.V. -- Central Mechanisms of Peripheral nerve stimulation in headache disorders / Bartsch, T., Goadsby, P.J. -- Peripheral nerve stimulation for chronic neurogenic Pain / Al-Jehani, H., Jacques, L. -- Percutaneous peripheral nerve stimulation / Al, K.M., Abramova, M.V., Richter, E.O. -- Peripheral nerve stimulation for the treatment of truncal pain / Cairns, K.D., McRoberts W.P., Deer, T. -- Peripheral subcutaneous stimulation for intractable abdominal pain / Barolat, G. -- Subcutaneous occipital region stimulation for intractable headache syndromes / Weiner, R.L. -- Peripheral nerve stimulation for occipital neuralgia: surgical leads / Kapural, L., Sable, J. -- Occipital nerve stimulation: technical and surgical aspects of implantation / Trentman, T.L., Zimmerman, R.S., Dodick, D.W. -- Peripheral neuromodulation for migraine headache / Ellens, D.J., Levy, R.M. -- Occipital neuromodulation for refractory headache in the chiari malformation population / Vadivelu, S., Bolognese, P., Milhorat, T.H., Mogilner, A.Y. -- Peripheral nerve stimulation in chronic custer headache / Magis, D., Schoenen, J. -- Peripheral nerve stimulation for fibromyalgia / Plazier, M. ... [et al.] -- Hybrid neurostimulator : simultaneous use of spinal cord and peripheral nerve field stimulation to treat low back and leg pain / Lipov, E.G. -- Stimulation of the peripheral nervous system for the painful extremity / McRoberts, W.P., Cairns, K.D., Deer, T. -- Sphenopalatine ganglion interventions: technical aspects and application / Oluigbo, C.O. ... [et al.] -- Spinal nerve root stimulation / Kellner, C.P., Kellner, M.A., Winfree, C.J. -- Technical aspects of peripheral nerve stimulation: hardware and complications / Slavin, K.V. -- Peripheral nerve stimulation: definition / Abejcentn, D., Perez-Cajaraville, J. -- The future of peripheral nerve stimulation / Stanton-Hicks, M. ... [et al.].
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    Basic concepts and glossary of common clinical terms -- Anatomic classification of peripheral nervous system disorders -- Evaluation and management of the patient with peripheral neuropathy -- Electrodiagnostic, imaging, nerve, and skin biopsy investigations in peripheral nerve diseases -- Case presentations illustrating the diagnostic method -- Acute immune-mediated neuropathies -- Chronic immune-mediated neuropathies -- Neuropathies associated with monoclonal gammopathies and cancer -- Infectious and granulomatous neuropathies -- Diabetic and other endocrine neuropathies -- Neuropathies associated with vitamin deficiencies and malabsorption -- Vascular/ischemic neuropathies -- Neuropathies associated with organ failure -- The hereditary neuropathies -- Hereditary metabolic/multisystem disorders with neuropathy -- The toxic neuropathies : principles of general and peripheral neurotoxicology, pharmaceutical agents -- The toxic neuropathies : industrial, occupational, and environmental agents -- Focal neuropathies : nerve injuries, entrapments, and other mononeuropathies -- Plexopathies -- Disorders of peripheral nerve hyperexcitability.
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    Ch. 1 Viewing the peripheral fundus -- Ch. 2 Anatomy of the peripheral fundus -- Ch. 3 Developmental anomalies, degeneration, and diseases of the peripheral retina and pars plana -- Ch. 4 Vitreous degeneration related to peripheral retinal breaks and retinal detachment -- Ch. 5 Peripheral retinal breaks -- Ch. 6 Retinal detachment -- Ch. 7 Proliferative vitreoretinopathy -- Ch. 8 Choroidal detachment .
  • Peripheral vascular disease : basic and clinical perspectives / Erich Minar & Martin Schillinger -- Epidemiology, risk factors & prognosis / Beau M. Hawkins & Michael R. Jaff -- Clinical and noninvasive diagnosis / Wolfgang Mlekusch -- Lifestyle and exercise therapy for peripheral vascular disease / Curt Diehm & Nicolas Diehm -- Medical therapy for peripheral vascular disease / Rudolf Kirchmair & Peter Marschang -- Endovascular therapy for peripheral vascular disease / Martin Schillinger & Erich Minar -- Surgical approaches in peripheral vascular disease / Mehtab Ahmad & Andrew Bradbury -- Index.
  • General -- Material -- Methods -- Abdomen -- Lower extremities -- Upper extremities -- Other endovascular interventions -- Complications -- Recurrent stenosis -- Documentation and postprocessing.
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  • Diagnostic Biopsy Procedures -- Cutaneous Surgery -- Hand Surgery -- Foot Surgery -- Hernia Surgery -- Head and Neck Surgery.
  • Indications for central venous cannulation in critically ill patients have increased dramatically in recent years owing to the use of more complex therapies unsuitable for delivery via peripheral veins. The main drawbacks of central venous access are morbidity and the growing scarcity of experienced operators. Ultrasound-guided peripheral venous access offers a solution, in that it reduces morbidity and can be performed by a dedicated nursing team. The aim of this book is to teach the fundamentals of this emerging technique. Advice is provided on the choice of materials and on vein selection. The advantages and disadvantages of peripherally inserted central venous catheters (PICC) in relation to other types of central venous catheter are discussed, and the principles of use and practical applications of ultrasound for venipuncture are explained. Maneuvers for PICC positioning, techniques for the evaluation of PICC tip placement, and the prevention, diagnosis, and management of complications are all described in detail. Advice is also provided on the organization of a dedicated PICC team within a hospital or a supportive care program, and psychological, legal, and economic issues are considered. Peripherally Inserted Central Venous Catheters will be of interest to a wide range of professionals, including nutritionists, oncologists, anesthesiologists, surgeons, registered nurses, nurse practitioners, physicians, physician assistants, and radiologists.
  • Periprosthetic Joint Infection of the Hip and Knee is a practical reference for the diagnosis and treatment of total joint infections following hip and knee arthroplasty. In addition to useful chapters presenting common tests and algorithms used for diagnosis, the book gives background on the epidemiology, risk factors, and prevention strategies of periprosthetic joint infection. Additionally, practical clinical information is given, including antibiotic treatment strategies and delivery methods and medical optimization techniques for physicians to follow for patient care and follow-up. Covering a topic that is currently underrepresented in the medical literature, Periprosthetic Joint Infection of the Hip and Knee will be useful to orthopedic surgeons, rheumatologists, and other physicians involved in the care of patients with hip and knee prosthetic implants.
  • Preface / Ronco, C -- The International Vicenza Course on Peritoneal Dialysis, 30 year anniversary / Nolph, KD -- Twenty years of bicarbonate solutions / Feriani, M -- Peritoneal dialysis solution and nutrition / Verger, C -- Alternative dialysis strategies with icodextrin / Panzer, SE; Teitelbaum, I -- Are current peritoneal dialysis solutions adequate for pediatric use? / Verrina, EE ...[et al.] -- Brazillan Peritoneal Dialysis Multicenter Study (BRAZPD), from conception to execturion of a national peritoneal dialysis reality check / Divino-Filho, JC ... [et al.] -- Comparing outcomes of hemodialysis and peritoneal dialysis patients, consider the pitfalls / Mehrotra R -- Hypogonadism in males with chronic kidney disease, another cause of resistance to erythropoiesis-stimulating agents? / Stenvinkel P; Barany P -- Getting the right patient on the right renal replacement therapy / Perez Fontan M ... [et al.] -- Doubts on the long-term survival of peritoneal dialysis patients are no longer a medical barrier to home dialysis / Lameire, N ; Van Biesen, W -- How to avoid technique failure in peritoneal dialysis patients? / Lobbedez, T ... [et al.] -- Clinical practice guidelines, an important tool in improving dialysis quality / Lamiere, N; Van Biesen, W -- Remote monitoring for continuous peritoneal dialysis / Rosner, MH; Ronco, C -- e-Health, remote health care models in peritoneal dialysis / Struijk, DG -- Remote monitoring of peritoneal dialysis in special locations / Nayak, A; Antony, S; Nayak, KS -- Dialysis modality choice for the elderly patient with end-stage renal disease / Rosner, MH; Ronco, C -- Anemia management in patients on peritoneal dialysis / Del Vecchio, L; Cavalli, A; Locatelli, F -- Maximizing the erythropoietin response, iron strategies / Prabhu, MV ... [et al] -- Lipid disorders in uremia and dialysis / Bakris, GL -- Statins and lipid-lowering strategies in PD / Heimburger, O -- Statin therapy is associated with decreased small, dense low-density lipoprotein levels in patients undergoing peritoneal dialysis / Clementi, A ... [et al.] -- Phosphate control in peritoneal dialysis / Cozzolino, M ... [et al.] -- Role of vitamin D receptor activators in peritoneal dialysis / Bover, J ... [et al.] -- Calcimimetics in peritoneal dialysis patients / Messa P; Castelnovo, C; Scalamogna, A -- Factors affecting loss of residual renal function(s) in dialysis / Raimann, JG; Kitzler, TM; Levin, NW -- Prospective safety study of bardoxolone methyl in patients with Type 2 diabetes mellitus, end-stage renal disease and peritoneal dialysis / Warnock, DG ... [et al.] -- Assessment of fluid status in peritoneal dialysis / Woodrow G; Ronco C -- Fluid transport and homeostasis in peritoneal dialysis / Teixido Planas, J -- Bioimpedance and brain natriuretic peptide in peritoneal dialysis patients / Crepaldi, C ... [et al.] -- Role of peritoneal dialysis as a chronic renal replacement therapy in cardiorenal patients / Pego, C; Rodrigues, A; Ronco, C -- Vascular and arterial calcification in peritoneal dialysis patients, state of the art 2012 / Heymann, EP; Penny, H; Goldsmith, DJA -- Adequacy in peritoneal dialysis / Ryckelynck, J-P ... [et al.] -- Setting up research in peritoneal dialysis -- Continuous flow peritoneal dialysis, update 2012 / Amerling, R; Winchester, JF; Ronco, C -- Combination therapy, five days PD and one day HD-what are the benefits? / Burkart, J -- Peritoneal dialysis access, what's the best approach? / Riella, MC; Chula DC -- Time between peritoneal dialysis catheter insertion and use / Elhassan E; Teitelbaum, I -- Peritoneal diallysis membrane evaluation in clinical practice / Krediet, RT; Struijk -- Bioelectrical impedance analysis in the assessment of hydration status in peritoneal dialysis patients / Haapio, M ... [et al.] -- Today's approaches to prevent peritonitis / Piraino, B -- Transplant outcomes and dialysis modality / Fuquay, R; Teitelbaum, I -- Neutrophil gelatinase-associated lipocalin in the early diagnosis of peritonitis, the case of neutrophil gelatinase-associated lipocalin / Martino, FK ... [et al.] -- Prognostic factors for peritonitis outcome / van Esch, S; Krediet, RT; Struijk, DG -- Improving the care of diabetic patients on peritoneal dialysis / Dalal, P; Misra, M -- How to select among dialysis options / Mooney, A.
  • 1. Anatomy of Peritoneum and Preoperative Assessment of Patients with Peritoneal Surface Malignancies -- 2. Surgical Technique for Cytoreductive Surgery -- 3. Intraperitoneal Chemotherapy Applications -- 4. Management of Special Issues -- 5. Molecular Mechanism of Peritoneal Metastases.
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  • Introduction: Formulation of the problem -- Normal or innocent murmurs -- Cardiac malpositions -- Isolated congenital complete heart block -- Congenital abnormalities of the pericardium -- Congenitally corrected transposition of the great arteries -- Congenital aortic stenosis: Congenital aortic regurgitation -- Coarctation of the aorta and interrupted aortic arch / Congenital obstruction to left atrial flow: Mitral stenosis, cor triatriatum, pulmonary vein stenosis -- Endocardial fibroelastosis -- Congenital pulmonary stenosis -- Congenital pulmonary valve regurgitation -- Ebstein's anomaly of the tricuspid valve -- Primary pulmonary hypertension -- Atrial septal defect: Simple and complex -- Pulmonary stenosis with interatrial communication -- Ventricular septal defect -- Ventricular septal defect with pulmonary stenosis -- Double outlet ventricle -- Patent ductus arteriosus aortopulmonary window -- Anomalous origin of the left coronary artery from the pulmonary trunk -- Congenital coronary arterial fistula -- Congenital aneurysms of the sinuses of valsalva -- Pulmonary atresia with intact ventricular septum -- Tricuspid atresia -- Univentricular heart -- Complete transposition of the great arteries -- Truncus arteriosus -- Congenital anomalies of vena caval connection -- Congenital pulmonary arteriovenous fistula -- Hypoplastic left heart -- Congenital anomalies of the coronary circulation.
  • Print Material
    "Permanent Present Tense tells the incredible story of Henry Gustave Molaison, known only as H. M. until his death in 2008. In 1953, at the age of twenty-seven, Molaison underwent a dangerous "psychosurgical" procedure intended to alleviate his debilitating epilepsy. The surgery went horribly wrong, and when Molaison awoke he was unable to store new experiences. For the rest of his life, he would be trapped in the moment. But Molaison's tragedy would prove a gift to humanity. The amazing specificity of his impairment shed new light on the functions and structures of the human brain, revolutionizing neuroscience. Today, the case of H. M. stands as one of the most consequential and widely referenced in this fast-expanding field. Renowned neuroscientist Suzanne Corkin worked with Molaison for nearly five decades. In Permanent Present Tense, she tells the full story of his life and legacy, leading her reader to the cutting edge of neuroscience with great clarity, sensitivity, and grace. "-- Provided by publisher.
  • Introduction / Leopold Flohé and J. Robin Harris -- Evolution of the peroxiredoxins / Bernard Knoops, Eléonore Loumaye and Valérie Van Der Eecken -- Structural survey of the peroxiredoxins / P. Andrew Karplus and Andrea Hall -- The catalytic mechanism of peroxiredoxins / Leslie B. Poole -- Kinetics of peroxiredoxins and their role in the decomposition of peroxynitrite / Madia Trujillo ... [et al.] -- The peroxiredoxin repair proteins / Thomas J. Jönsson and W. Todd Lowther -- Peroxiredoxins in bacterial antioxidant defense / James M. Dubbs and Skorn Mongkolsuk -- The NADH oxidase-Prx system in Amphibacillus xylanus / Youichi Niimura -- Peroxiredoxin systems in mycobacteria / Timo Jaeger -- Peroxiredoxin systems of protozoal parasites / Marcel Deponte, Stefan Rahlfs and Katja Becker -- The trypanothione system / Luise R. Krauth-Siegel, Marcelo A. Comini and Tanja Schlecker -- Functions of typical 2-Cys peroxiredoxins in yeast / Brian A. Morgan and Elizabeth A. Veal -- The dual function of plant peroxiredoxins in antioxidant defence and redox signaling / Karl-Josef Dietz -- Mitochondrial peroxiredoxins / Zhenbo Cao, J. Gordon Lindsay and Neil W. Isaacs -- Peroxiredoxins in the lung with emphasis on peroxiredoxin VI / Bruno Schremmer ... [et al.] -- Peroxiredoxins in gametogenesis and embryo development / Isabelle Donnay and Bernard Knoops -- Peroxiredoxins in the central nervous system / Fumiyuki Hattori and Shinzo Oikawa -- Stress-induced peroxiredoxins / Tetsuro Ishii and Toru Yanagawa.
  • Introduction -- History of PPAR Discovery -- Peroxisome Proliferator-Activated Receptors -- PPAR Ligands -- Tissue Distribution and Versatile Functions of PPARs -- PPARs and Drug Metabolism -- Molecular Aspects of PPAR Actions -- Animal Models in PPAR Research -- Safety of PPAR Agonists -- The Future of PPAR Research.
  • Peroxisomes are a class of ubiquitous and dynamic single membrane-bounded cell organelles, devoid of DNA, with an essentially oxidative type of metabolism. In recent years it has become increasingly clear that peroxisomes are involved in a range of important cellular functions in almost all eukaryotic cells. In higher eukaryotes, including humans, peroxisomes catalyze ether phospholipids biosynthesis, fatty acid alpha-oxidation, glyoxylate detoxification, etc, and in humans peroxisomes are associated with several important genetic diseases.
  • Scientific basis of cancer chemotherapy -- Norton-Simon hypothesis -- Drug resistance -- Principles of chemotherapy -- Clinical trials -- Hematopoietic growth factors -- Biologic response modifiers: principles of biotherapy -- Intraventricular and intrathecal therapy -- Intraperitoneal chemotherapy -- Intraarterial chemotherapy -- Hematopoietic stem cell transplantation -- Oral toxicity -- Dermatologic toxicity -- Extravasation -- Hypersensitivity reactions -- Ocular side effects of cancer therapeutics -- Cardiotoxicity of cancer therapy -- Pulmonary toxicity of chemotherapeutic agents -- Gastrointestinal complications of chemotherapy -- Hepatotoxicity of chemotherapeutic agents -- Chemotherapy-induced renal and electrolyte dysfunction -- Chemotherapy-induced peripheral neuropathy -- Vascular toxicity of antineoplastic agents -- Second malignancies after chemotherapy -- Chemotherapy in pregnancy -- Gonadal complications and teratogenicity of cancer therapy -- Central venous access for chemotherapy -- Systemic therapy for advanced melanoma -- Chemotherapy of primary brain tumors -- Chemotherapy for head and neck cancer -- Chemotherapy of lung cancer -- Breast cancer -- Gastrointestional cancer -- Endocrine tumors -- Chemotherapy of genitourinary cancer -- Chemotherapy of gynecologic cancers -- Chemotherapy of carcinoma of unknown primary site -- Chemotherapy of bone and soft tissue sarcomas -- Chemotherapy for pediatric solid tumors -- Chemotherapy for childhood leukemia -- Chemotherapy of Hodgkin lymphoma -- Non-Hodgkin lymphoma -- Chronic lymphocytic leukemia -- Acute myeloid leukemia -- Myelodysplastic syndromes -- Management of myeloproliferative disorders and chronic myeloid leukemia -- Chemotherapy of multiple myeloma -- Appendics: I: Chemotherapeutic agents -- II: Chemotherapy programs -- III: Common terminology criteria for adverse events (CTCAE) version 4.0.
  • The book revisits the causes of persisting undernutrition in India, but moves away from the usual focus on women and children to a broader view of the entire population. It estimates the economic losses resulting from ignoring undernutrition in the adult working population, and questions the current narrow focus of nutrition interventions, suggesting that a family-based approach may provide quicker results and long-term sustainability. It compares the best and worst performing states in the country to glean learnings from both successes and failures and emphasizes the need to hand over the ownership of nutrition outcomes from the state to the community and family for more sustainable results. The book is organized in three sections: Part 1 details the nutrition status of the population, regional variations in nutrition outcomes, and government response in terms of interventions. Part 2 reviews issues and concerns like gender discrimination, poor child nutrition status, ineffective implementation of government programmes in the field, and the possible impacts of emerging issues like climate change. Part 3 seeks solutions from both international and country experiences.
  • Inverted perspectives: triggering change / Tom Munnecke and Robert M. Kolodner -- A window of opportunity / Robert M. Kolodner -- HealthePeople: person-centered, outcomes-driven, virtual health systems / Gary A. Christopherson -- The value of electronic health records / Blackford Middleton -- Personal outcomes in health care / Thomas L. Garthwaite -- Human factors: changing systems, changing behaviors / Marion J. Ball and Judith V. Douglas -- Laying the foundations: information architecture for HealthePeople / James E. Demetriades -- Critical areas of standardization / Jeffrey S. Blair and Simon Cohn -- The role of terminology in future health information systems / Steven H. Brown, Michael J. Lincoln, and Peter L. Elkin -- Modeling for health care / Kenneth S. Rubin, Thomas Beale, and Bernd Blobel -- HealthePeople security architecture / Bernd Blobel and John M. Davis -- Open source health systems / Dipak Katra and David Forslund -- Critical standards convergence / Steven Wagner and J. Michael Fitzmaurice -- A European perspective on the cultural and political context for deploying the electronic health record / Angelo Rossi Mori and Gerard Freriks -- Convergence toward the Pan-Canadian electronic health record / Julie Richards, Shari Dworkin, and Nancy Gill -- HealthConnect: a health information network for all Australians / David Rowlands -- The Veterans Health Administration: quality, value, accountability, and information as transforming strategies / Jonathan B. Perlin and Robert M. Kolodner.
  • The next frontier for user-centered design : making user representations more usable -- The persona lifecycle : a framework for the persona approach -- Phase 1: Family planning (planning a persona effort) -- Phase 2: Conception & gestation (creating personas) -- Phase 3: Birth & maturation (launching and communicating personas) -- Phase 4: Adulthood (using personas) -- Phase 5: Lifetime achievement and retirement (ROI and reuse of personas) -- Contributed chapters: Users, roles and personas / by Larry Constantine -- Storytelling and narrative / by Whitney Quesenbery -- Reality and design maps / by Tamara Adlin & Holly Jamesen -- Marketing versus design personas / by Bob Barlow-Busch -- Why personas work : the psychological evidence / by Jonathan Grudin -- Appendix A: G4K organizational archetype and sample persona -- Appendix B: Example personas from real projects -- Appendix C: Sample image release form.
  • Another view of psychotherapy? / Herbert J. Schlesinger -- Personality in context : reflections on the contributions of David Shapiro / Paul L. Wachtel -- A new developmental foundation for David Shapiro's work on autonomy and character / E. Virginia Demos -- Two configurations of personality development and psychopathology : etiologic and therapeutic implications / Sidney J. Blatt -- Autonomy and schizophrenia : reflections on an ideal / Louis A. Sass -- Reconceptualizing defense, unconscious processes, and self-knowledge : David Shapiro's contribution / Morris N. Eagle -- Defensive styles of thinking to prevent dreaded states of mind / Mardi J. Horowitz -- Self-deceptive speech : a psycholinguistic view / Michael F. Schober and Peter J. Glick -- Neurotic self-deception as a reproductive strategy / Lawrence Josephs -- David Shapiro's characterology and complex systems theory / Craig Piers -- I don't want to want to : intentionality and craving in addiction / Mindy Greenstein -- Activity, passivity, and the subjective experience of hypomania / Andreas Evdokas and Ali Khadivi -- Appendix A : On two fundamental categories of psychopathology / David Shapiro -- Appendix B : Publications by David Shapiro.
  • Personalized management of breast cancer / Travis L. Holloway & Ismail Jatoi -- Diagnosis and biomarkers / Aysegul Sahin & Alexandra Shaye Brown -- Molecular subtypes of breast cancer / Henry O. Ebili, A. Olayiwola Oluwasola & Olufunmilayo I. Olopade -- Surgery and radiotherapy : patient selection and clinical outcomes / Travis Holloway & Ismail Jatoi -- Hormone-blocking therapy : patient selection and clinical outcomes / Annie R. Su & Mothaffar F. Rimawi -- EGF receptor inhibitors : patient selection and clinical outcomes / Sean Warsch, Gabriel Tinoco, Stefan Glück, Kiran Avancha & Alberto J. Montero -- Antiangiogenic therapy : patient selection and clinical outcomes / Sheeba Irshad, Andrew Tutt & Paul Ellis -- Current guidelines of breast cancer management / Cristina Falci, Zora Baretta & Silvio Monfardini -- Management algorithms of breast cancer / Paolo Carli, Loredana Militello, Elena Torrisi, Alessando Tuzi & Andrea Veronesi -- Index.
  • Personalized management of colorectal cancer / Alfredo Falcone & Fotios Loupakis -- Adjuvant treatment of stage II colon cancer : yes or no, what, when and why? / Joleen Hubbard & Daniel J. Sargent -- Adjuvant treatment of stage III colon cancer : where are we and will we ever move forward? / Benoît Rousseau & Christophe Tournigand -- Challenges in the neoadjuvant treatment of rectal cancer / Robert Glynne-Jones -- Molecular markers in radically resected colorectal cancer : from prognosis to prediction / Wu Zhang, Peter M. Wilson, Sebastian Stintzing & Heinz-Josef Lenz -- Liver-limited resectable stage IV : current reality and future perspectives / Dario Ribero & Simone Conci -- Choosing the right biologic agent in the 'continuum-of-care era' : a clinical perspective / Chiara Cremolini & Axel Grothey -- Index.
  • Current therapies for HNC : why is immunotherapy not yet in the forefront? / Theresa L. Whiteside -- Etiology and risk factors / Ana Neumann, Lei Jin & Qingyi Wei -- Molecular diagnostics of head and neck cancer / Diana Bell & Adel K. El-Naggar -- Classification and prevalence / Luiz Paulo Kowalski -- Surgery and radiotherapy : patient selection and clinical outcomes / Jonas T. Johnson -- Chemotherapy and molecularly targeted therapies for previously untreated SCCHN / Scott A. Kono, Nabil F. Saba & Dong M. Shin -- Chemotherapy and molecularly targeted therapies for recurrent head and neck cancer / Thomas K. Hoffmann & Patrick J. Schuler -- Prognostic biomarkers in squamous cell carcinoma of the head and neck / Vasu Divi & Carol Bradford -- Consensus guidelines / Carol M. Lewis & Randal S. Weber -- Index.
  • Personalized management of lung cancer / Ritsuko Komaki -- Molecular subtypes of non-small-cell lung cancer / Thomas E. Stinchcombe -- Screening and risk factors / Claudia I. Henschke, James P. Smith, David F. Yankelevitz & Rowena Yip -- Staging and prognosis / Elizabeth A. David, Daniel R. Gomez, Ritsuko Komaki & Garrett L. Walsh -- Surgical approach : patient selection and clinical outcomes / Boris Sepesi -- Radiotherapy : patient selection and clinical outcomes / Heath D. Skinner & Ritsuko Komaki -- Adjuvant therapy for non-small-cell lung carcinoma following surgical resection / Steven H. Lin -- Chemotherapy and molecularly targeted agents for advanced non-small-cell lung cancer / Charles Lu -- Use of thoracic radiation therapy for small-cell lung cancer / Steven E. Schild -- Limited-stage small-cell lung cancer : prophylactic cranial irradiation / Cecile Le Pechoux & Hweej Al Mokhles -- Small-cell lung cancer : treatment of extensive-stage disease / Lauren Averett Byers & John V. Heymach -- EGFR inhibitors : patient selections and clinical outcome / Rafael Rosell & Laura Bonanno -- Antiangiogenic therapy for non-small-cell lung cancer : patient selection and clinical outcomes / Suresh S. Ramalingam & Chandra P. Belani -- Considerations of practice guidelines and recommendations / Nan Bi & Feng-Ming (Spring) Kong -- Novel agents in development and future directions / George R. Simon -- Index.
  • Personalized management of multiple sclerosis / Bianca Weinstock-Guttman, Murali Ramanathan & Robert Zivadinov -- Epidemiology and classification / Julia Pakpoor & Sreeram V. Ramagopalan -- Pathophysiology of multiple sclerosis : a controversial new perspective / Johannes M. van Noort & Sandra Amor -- Symptoms and diagnosis of multiple sclerosis / Eva Havrdová & Jana Lizrova Preiningerova -- Management of acute multiple sclerosis attacks / Finn T. Sellebjerg -- Disease-modifying treatments for relapsing-remitting multiple sclerosis / Per Soelberg Sørensen -- Disease-modifying treatments for secondary progressive and progressive relapsing multiple sclerosis / Laura J. Edwards & Cris Constantinescu -- Head-to-head versus therapy-change studies / Carlo Pozzilli & Luca Prosperini -- MRI as a surrogate marker for clinical outcomes in multiple sclerosis / Maria Pia Sormani -- Measurement of cerebral atrophy in multiple sclerosis / Ernst-Wilhelm Radue, Kerstin Bendfeldt & Till Sprenger -- Symptomatic therapy for multiple sclerosis / Scott E. Jarvis, Aaron Mackie & Luanne M. Metz -- Neurologic rehabilitation in multiple sclerosis / Susan E. Bennett -- Treatment of pediatric multiple sclerosis / Angelo Ghezzi -- Complementary and alternative treatments / Allen C. Bowling -- Future directions in multiple sclerosis / Anat Achiron -- Index.
  • Opportunities and challenges in nutrigenetics/nutrigenomics and health / De Caterina, R. -- Genome-wide association studies and diet / Ferguson, L.R. -- Copy number variation, eicosapentaenoic acid and neurological disorders : with particular reference to Huntington's disease and associated CAG repeats and to myalgic encephalomyelitis and viral infection / Puri, B.K.; Manku, M.S. -- Nutrigenetics : a tool to provide personalized nutritional therapy to the obese / Marti, A.; Goyenechea, E.; Martínez, J.A. -- Xenobiotic metabolizing genes, meat-related exposures, and risk of advanced colorectal adenoma / Ferrucci, L.M. ... [et al.] -- Strategies to improve detection of hypertension genes / Hunt, S.C. -- Diet, nutrition and modulation of genomic expression in fetal origins of adult disease / Jackson, A.A.; Burdge, G.; Lillycrop, K. -- Choline : clinical nutrigenetic/nutrigenomic approaches for identification of functions and dietary requirements / Zeisel, S.H. -- Dietary polyphenols, deacetylases and chromatin remodeling in inflammation / Rahman, I., Chung, S. -- Dietary manipulation of histone structure and function / Ho, E., Dashwood, R.H -- Changes in human adipose tissue gene expression during diet-induced weight loss / Svensson, P.-A. ... [et al.] -- Toxicogenomics and studies of genomic effects of dietary components / Thompson, K. -- Dietary methyl deficiency, microRNA expression and susceptibility to liver carcinogenesis / Starlard-Davenport, A. ... [et al.] -- Redox dysregulation and oxidative stress in schizophrenia : nutrigenetics as a challenge in psychiatric disease prevention / Do, K.Q., Conus, P.; Cuenod, M. -- Nutrigenomics and agriculture : a perspective / Spence, J.T. -- Opportunities and challenges in nutrigenetics/nutrigenomics : building industry-academia partnerships / Gillies, P.J. ; Kris-Etherton, P.M. -- Tailoring foods to match people's genes in New Zealand : opportunities for collaboration / Ferguson, L.R. ... [et al.].
  • This book is a quick reference guide to the new, more personalized approaches to the management of skin disorders that have emerged as a result of progress in our understanding of the genetic background and pathophysiology of skin diseases and the diversity of mechanisms underlying their clinical heterogeneity. A wide range of personalized and targeted therapies are described, including those for different skin cancers, chronic inflammatory skin diseases, and autoimmune diseases. In addition, readers will find that the book documents how research results in personalized medicine can be effectively transferred to dermatological practice and looks forward to future treatments that might be developed on the basis of recent research findings. The authors are all recognized experts in the field, and the text is presented in a reader-friendly format and well illustrated.
  • Being a complex disease that affects millions of people world over, cancer research has assumed great significance. Translational cancer research transforms scientific discoveries in the laboratory or population studies into clinical application to reduce incidence of cancer, morbidity and mortality. It is becoming increasingly evident that cancer is a preventable disease. The IVth International Symposium on Translational Cancer Research held in Udaipur, India in December 2011, discussed various aspects of the biological processes in cancer cells and approaches to cancer prevention.
  • "Perspectives in Inflammation Biology" outlines detailed studies using preclinical murine models in Inflammation. The book is meant for academicians, industry persons, research scholars and students alike. The detailed perspective for a beginner and the exhaustive methodologies and analyses outlined, for the veteran researcher, makes this book a unique link between someone who is thinking of embarking on a study of inflammation and one who is delving deep into this area of specialization. The book deals with asthma and allergy as specific disease areas of inflammation of the lung, aseptic peritonitis as a disease of systemic inflammation and details how each role player in its pathophysiology has a unique niche of activity. Data acquisition, sequentiality and analyses in context demonstrate how each role player is validated systematically to become a target for drug discovery. Methods and models used in the course of my work and their relevance will demonstrate to the researcher how a study can be developed from an idea. Further into a researcher's ongoing work, this book is meant to stimulate new questions and pave ways for better dissection of a phenomenon. The highlights of this book are the detailed tables tabulating sub species of immune cells, their inflammatory recruitment indices, their translation into tissue-to-tissue traffic of the inflammatory stimulus and the delicate interplay of resident structural cells, cells recruited from circulation, their feedback poiesis in bone marrow, their instruction in the lymphoid organs and tissues as well as the non-cellular mediators synthesized from corresponding genetic instruction. The book shall definitely help students and researchers how a disease can be simplified from its complex ramifications and network of implications and put back into perspective and the whole thing falls into place without an intimate understanding of the mechanism and the compelling circumstances that causes a disease, a drug hunter cannot hope to begin her quest. To find the Achilles heel and effectively neutralize the enemy!
  • Print Material
  • KM and urban health. Knowledge management for the urban health context / M. Chris Gibbons, Rajeev K. Bali, and Nilmini Wickramasinghe -- Healthcare knowledge management : incorporating the tools technologies strategies and process of KM to effect superior healthcare delivery / Nilmini Wickramasinghe -- Knowledge Management in the urban health context : moving towards tacit-to-tacit knowledge transfer / Rajeev K. Bali, Vikram Baskaran, and Raouf N.G. Naguib -- Incorporating KM principles into urban health contexts. A childhood/adolescent knowledge management system for urban area health programs in the District of Columbia / Michael L. Popovich and Xiaohui Zhang -- Urban health in developing countries / Siddharth Agarwal, Aradhana Srivastava, and Sanjeev Kumar -- A pervasive wireless knowledge management solution to address urban health inequalities with indigenous Australians / Nilmini Wickramasinghe, Indrit Troshani, and Steve Goldberg -- The development of a framework to evaluate the management of HIV/AIDS programmes in rural and urban South Africa / Rochelle Sassman ... [et al.] -- The potential of serious games for improving health and reducing urban health inequalities / M. Chris Gibbons -- Measures and metrics for KM and urban health. A scalable and viable strategy for managing organization : typology of intervening into complex healthcare environment for enhancing its continual development / Murako Saito -- Amplifying resonance in organizational learning process : knowledge sharing for overcoming cognitive barriers and for assuring positive action / Murako Saito -- Developing new urban health metrics to reduce the know-do gap in public health / Carlos Castillo-Salgado and Michael Christopher Gibbons -- Recommendations on evaluation and development of useful metrics for urban health / Carlos Castillo-Salgado and M. Chris Gibbons -- Making sense of urban health knowledge / Rajeev K. Bali ... [et al.].
  • A brief history of SHAR -- Structures, mechanisms, and energetics in temporal processing -- Human auditory cortex: in search of the flying Dutchman -- From cajal to the connectome: building a neuroanatomical framework for understanding the auditory system -- Recording from hair cells -- Three decades of tinnitus-related research -- The sense of hearing in fishes -- A quarter-century's perspective on a psychoacoustical approach to loudness -- Nonsyndromic deafness: it ain't necessarily so -- Evolving mechanosensory hair cells to hearing organs by altering genes and their expression: the molecular and cellular basis of inner ear and auditory organ evolution and development -- The implications of discharge regularity: my forty-year peek into the vestibular system -- Aging, hearing loss, and speech recognition: stop shouting, i can't understand you -- Cochlear mechanics, otoacoustic emissions, and medical olivocochlear efferents: twenty years of advances and controversies along the areas ripe for new work -- Examining fish in the sea: a European perspective -- The behavioral study of mammalian hearing -- Hearing in insects: the why, when, and how -- The cognitive auditory system: the role of learning in shaping the biology of the auditory system -- Fundamentals of hearing in amniote vertebrates -- Directional hearing in insects and other small animals: the physics of pressure-difference receiving ears -- Distributed cortical representation of sound locations -- Pitch: mechanisms underlying the pitch of pure and complex tones -- Unavoidably delayed: apersonal perspective of twenty years of research on a sound localization cue -- Size matters in hearing: how the auditory system normalizes the sounds of speech and music for source size -- A changing view of the auditory system obtained from the ears of bats -- From cave fish to pile driving: a tail of fish bioacoustics -- Current topics in the study of sound conduction to the inner ear -- From degenerative debris to neuronal tracing: an anterograde view of auditory circuits -- Adventures in bionic hearing -- My dull deaf ears: four millennia of acquired hearing loss -- What's the use of genetics? -- Advances in the understanding of binaural information processing: consideration of the stimulus as processed -- Temporal processing: observations on the psychophysics and modeling of temporal integration and temporal resolution -- Psychoacoustics and auditory perception -- Appendix. The first 49 volumes.
  • Introduction to a conversation / Jeff Malpas and Norelle Lickiss -- Human dignity and human worth / Daniel P. Sulmasy -- Human dignity and human being / Jeff Malpas -- On human dignity: fragments of an exploration / Norelle Lickiss -- Two conceptions of dignity : honour and self-determination / Andrew Brennan and Y.S. Lo -- Human dignity and charity / Rosalind Hursthouse -- Human dignity: functions and meanings / Doron Shultziner -- A brief history of human dignity: idea and application / Milton Lewis -- A Journey towards understanding: true and false dignity / Christina Mason -- The question of human dignity: doubts and loves and a whisper from where the ruined house once stood / Veronica Brady -- Human dignity: a borderline heretical response / Stuart Blackler -- Giving the past its dignity / Greg Dening -- Dignity and indignity / Nicholas Tarling -- Human dignity and the law / Sir Guy Green -- On the international legal aspects of human dignity / Don Chalmers and Ryuichi Ida -- Doing justice to dignity in the criminal law / Julia Davis -- Human dignity: the new phase in international law / Michael Tate -- Dignity and health / Martin Tattersall -- Human dignity : the perspective of a gynaecological oncologist / Neville F. Hacker -- The social origins of dignity in medical care at the end of life / Nicholas Cristakis -- Dying with dignity : the story reveals its meaning / Jack Coulehan.
  • Overview of healthcare, disease, and disability / Jeffrey Kaye, Tracy Zitzelberger -- Computer science tools and techniques / Martha E. Pollack, Bart Peintner -- Pervasive computing in hospitals / Jakob E. Bardram, Heribert Baldus, Jesus Favela -- Pervasive computing in the home and community / Donald J. Patterson, Henry A. Kautz, Dieter Fox, Lin Liao -- Mobile and personal health and wellness management systems / Elina Mattila, Ilkka Korhonen, Niilo Saranummi -- Sensors and wearable technologies for pervasive healthcare / Sungmee Park, Sundaresan Jayaraman -- Assistive technologies / Edmund LoPresti -- Human factors and usability of healthcare systems / Andre Kushniruk, Elizabeth Borycki -- Routes and requirements for realizing pervasive medical devices / Michael P. Craven -- User evaluation in pervasive healthcare / Tim Adlam, Roger Orpwood, Teresa Dunn -- The business of pervasive healthcare / Dadong Wan, Luis E. Taveras.
  • Between rising costs and decreasing accessibility, the present health care picture is fraught with shortcomings--a discouraging scenario for the millions of patients struggling with chronic diseases such as diabetes and hypertension. In response, computer technology is emerging as a key factor in the transition from inefficient centralized health systems toward patient-centered, patient-involved care: pervasive healthcare. In straightforward fashion, Pervasive Health Knowledge Management systematically explains how mobile technologies and knowledge management (KM) can streamline health systems by removing time and place limitations, reducing costs, and giving patients a more proactive part in managing their conditions. The book defines the role of KM in pervasive healthcare and analyzes its component processes and technologies. Chapters examine how and why KM works, review KM initiatives within and outside the U.S., and offer extended coverage of possibilities for ubiquitous computing in managing diabetes. Together, they outline a future that meets mounting chronic health concerns with efficient, cost-effective, patient-empowering strategies. Highlights of the coverage: Implicit and explicit knowledge assets in healthcare.Using pervasive technologies to manage knowledge in crisis situations.Smart phone application design and knowledge management for people with dementia.A pervasive technology solution for supporting diabetes self-care.Examining the business and IT aspects of wireless enabled healthcare solutions.Developing an internet-based chronic disease self-management system. Healthcare administrators and researchers in healthcare management, health policy, and health services research will find detailed in Pervasive Health Knowledge Management a visionary approach to many of the most pressing problems in their fields.
  • Biotransformation of Pesticides is an updated, "one-stop" resource for academic, industry and regulatory scientists involved in research and regulatory activities related to pesticide biotransformation and human health. This book provides an in depth look at how pesticides are biotransformed, which is essential to understanding exposure, dose, toxicity and health risks. This essential reference contains the biotransformation of pesticides from uptake to excretion, including toxicokinetics and emphasizes metabolism in non-target species, including experimental animals and humans. Includes four new chapters and expanded material on pesticide biotransformation and disposition, an active area of pesticide toxicology that is becoming increasingly important for human health risk assessment. Offers a practical and portable guide covering the most up-to-date research results on metabolic transformations of pesticides. Provides scientists and regulatory researchers with the information they need to conduct accurate risk assessments and make informed decisions on which exposures to study further in human populations.
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  • Pesticide protocols 2005
    Springer Protocols
  • Presenting both oncological and nononcological applications, this book covers the full range of scenarios the clinician is likely to encounter in the professional setting. With a special focus on PET/CT correlation and FDG oncological imaging, this text addresses the important role of PET/CT in managing patients with cancer, Alzheimer.s disease, epilepsy, and other disorders. Each chapter in the Oncological Applications section of the text focuses on a particular disease, allowing the reader to quickly access the information relevant to managing a specific clinical situation. Thorough review of the existing scientific literature and pointers on how to interpret and report images provide readers with the tools to sharpen their assessment and decision-making skills and improve patient care.
  • PET and SPECT in Neurology highlights the combined expertise of renowned authors whose dedication to the investigation of neurological disorders through nuclear medicine technology has achieved international recognition. Classical neurodegenerative disorders are discussed as well as cerebrovascular disorders, brain tumors, epilepsy, head trauma, coma, sleeping disorders, and inflammatory and infectious diseases of the CNS. The latest results in nuclear brain imaging are detailed. Most chapters are written jointly by a clinical neurologist and a nuclear medicine specialist to ensure a multidisciplinary approach. This state-of-the-art compendium will be valuable to anybody in the field of neuroscience, from the neurologist and the radiologist/nuclear medicine specialist to the interested general practitioner and geriatrician. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences, the other volumes covering PET and SPECT in psychiatry and in neurobiological systems.
  • PET and SPECT of Neurobiological Systems combines the expertise of renowned authors whose dedication to the development of novel probes and techniques for the investigation of neurobiological systems has achieved international recognition. Various aspects of neurotransmission in the brain are discussed, such as visualization and quantification of (more than 20 different) neuroreceptors, neuroinflammatory markers, transporters, and enzymes as well as neurotransmitter synthesis, -amyloid deposition, cerebral blood flow, and the metabolic rate of glucose. The latest results in probe development are also detailed. Most chapters are written jointly by radiochemists and nuclear medicine specialists to ensure a multidisciplinary approach. This state of the art compendium will be valuable to anyone in the field of clinical or preclinical neuroscience, from the radiochemist and radiologist/nuclear medicine specialist to the interested neurobiologist and general practitioner. It is the second volume of a trilogy on PET and SPECT imaging in the neurosciences. Other volumes focus on PET and SPECT in psychiatry and PET and SPECT in "neurology".
  • PET in oncology 2008
  • PET Physics and Instrumentation / Brad Kemp -- PET Radiochemistry and Radiopharmacy / Mark S. Jacobson, Raymond A. Steichen and Patrick J. Peller -- PET/CT Interpretation / Patrick J. Peller -- Central Nervous System / Jeffrey A. Miller and Terence Z. Wong -- Head and Neck / Rathan M. Subramaniam, J. M. Davison, Ujas Parikh and M. Abou-Zied -- Chest / Rathan M. Subramaniam, J. M. Davison, D. S. Surasi, Gregory Russo and P. J. Peller -- Breast Cancer / Gustavo A. Mercier, Felix-Nicolas Roy and François Ba\0302enard -- Gastrointestinal / Roland Hustinx -- Genitourinary / Jacqueline Brunetti and Patrick J. Peller -- Gynecologic / Patrick J. Peller -- Musculoskeletal / Jeffrey J. Peterson -- Hematology / Rathan M. Subramaniam, Leonne Prompers, A. Agarwal, Ali Guermazi and Felix M. Mottaghy -- Dermatological / David Brandon and Bruce Barron -- Pediatric / Hossein Jadvar, Frederic H. Fahey and Barry L. Shulkin -- Assessment of Response to Therapy / Ali Gholamrezanezhad, Alin Chirindel and Rathan Subramaniam -- Metastatic Disease / Patrick J. Peller -- Radiotherapy Planning / Minh Tam Truong and Rathan M. Subramaniam -- Patients with HIV / Rathan M. Subramaniam, J. M. Davison, Devaki S. Surasi, T. Jackson and T. Cooley -- Pitfalls and Artifacts / Geoffrey Bates Johnson and Christopher Harker Hunt.
  • Importance of Radiotracers Other than FDG in Oncology / Luigi Mansi, Pier Francesco Rambaldi and Vincenzo Cuccurullo -- Considerations About PET Isotopes / Luigi Mansi, Vincenzo Cuccurullo and Pier Francesco Rambaldi -- Choline PET-CT / Mohsen Farsad, Vincenzo Allegri and Paolo Castellucci -- Methionine PET-CT / Cristina Nanni, Valentina Ambrosini and Stefano Fanti -- Fluoride PET-CT / Roland Hustinx and Catherine Beckers -- Tyrosine PET-CT / Mohsen Farsad and Gabriele Pöpperl -- Somatostatin Receptor PET-CT / Valentina Ambrosini, Paolo Castellucci, GianCarlo Montini and Stefano Fanti -- Acetate PET-CT / Mohsen Farsad, Franca Chierichetti and Stefano Fanti -- Thymidine PET-CT / Ken Herrmann and Andreas Buck -- Dopa PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga -- Imaging of Hypoxia with PET-CT / Tove J. Grönroos, Heikki Minn and Rodney J. Hicks -- Angiogenesis PET Using Radiolabeled RGD Peptides / Keon Wook Kang, Jae Min Jeong and Ambros J. Beer -- Hormonal Receptors PET-CT / Erik F. J. de Vries, Andor W. J. M. Glaudemans, Caroline P. Schröder and Geke A. P. Hospers -- HTP PET-CT / Adrienne H. Brouwers, Klaas P. Koopmans, Rudi A. J. O. Dierckx and Philip H. Elsinga.
  • PET-CT hybrid imaging 2010
    Thieme Book
    Basic principles -- Imaging of neoplastic diseases -- Inflammatory diseases / M. Luffler and J. Wessling -- Diagnosis of cardiovascular diseases / M. Schaefers and R. Fischbach -- Neurodegenerative diseases / M. Weckesser and T.-U. Niederstadt -- Developments and outlook / O. Schober and W. Heindel.
  • Provides practical, useful information for utilizing this novel imaging techniquefrom different methods for contouring biological target volumes in various anatomic regions to how different experts use this imaging in targeted treatment. This thorough text helps you make concise, accurate treatment choices based on current evidence and expert authority. The result is an helpful tool for everyone on the radiotherapy treatment team in the era of image-guided radiotherapy. Covers the use of PET-CT with radiotherapy treatment planning, offering practical guidance in how different experts use this relatively new technology. Outlines the advantages and disadvantages of different techniques in contouring PET-CT target volumes for radiotherapy. Features case illustrations in using PET-CT in radiotherapy.
  • PET-CT is increasingly being employed in the diagnosis of both oncological and non-oncological patients, yet nuclear medicine physicians may have only limited practical experience of rare diseases and may experience difficulty in recognizing and interpreting rare findings. This unique atlas documents a large number of clinical cases that will help practitioners to identify findings and diseases that, though rare, are sufficiently frequent to be encountered in routine practice. Two types of cases are presented: patients evaluated for rare diseases and patients evaluated for standard diseases in whom atypical PET findings were detected. Each reported case includes a brief description of the clinical history, representative color PET-CT images obtained using FDG or other tracers, and a short explanation of the disease and findings. This atlas will enable practitioners to make conclusive reports of PET-CT scans that would otherwise have been inconclusive.
  • Provides fundamental information to all clinicians interested in incorporating PET into their clinical practice and who are involved in the diagnosis, initial staging, and restaging of malignancy. Covers basic principles such as patient preparation, imaging interpretation, and reimbursement, to specific applications for oncologic, cardiac, and neurologic disorders.
  • PET/MRI is an exciting novel diagnostic imaging modality that combines the precise anatomic and physiologic information provided by magnetic resonance imaging (MRI) with the molecular data obtained with positron emission tomography (PET). PET/MRI offers the promise of a simplified work flow, reduced radiation, whole-body imaging with superior soft tissue contrast, and time of flight physiologic information. It has been described as the pathway to molecular imaging in medicine. In compiling this textbook, the editors have brought together a truly international group of experts in MRI and PET. The book is divided into two parts. The first part covers methodology and equipment and comprises chapters on basic molecular medicine, development of specific contrast agents, MR attenuation and validation, quantitative MRI and PET motion correction, and technical implications for both MRI and PET. The second part of the book focuses on clinical applications in oncology, cardiology, and neurology. Imaging of major neoplasms, including lymphomas and tumors of the breast, prostate, and head and neck, is covered in individual chapters. Further chapters address functional and metabolic cardiovascular examinations and major central nervous system applications such as brain tumors and dementias. Risks, safety aspects, and healthcare costs and impacts are also discussed. This book will be of interest to all radiologists and nuclear medicine physicians who wish to learn more about the latest developments in this important emerging imaging modality and its applications.
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  • 1. Introduction -- 2. Anatomy of the penis, with special attention to the tunica albuginea and to the corpora cavernosa -- 3. Epidemiology -- 4. Aetiology and risk factors -- 5. Nosology -- 6. Natural history of Peyronie's disease -- 7. Experimental models and laboratory research for Peyronie's disease -- 8. Symptoms, their physiopathology, and outpatient clinical practice and diagnosis -- 9. Congenital and acquired penile curvature: relationships and differences -- 10. Psychological aspects of Peyronie's diseaese -- 11. Imaging in Peyronie's disease -- 12. Therapy: a general approach -- 13. Medical therapy -- 14. Combination therapy (in the treatment of Peyronie's disease) -- 15. Surgical therapy for Peyronie's disease: why and when (an overview) --16. Advanced techniques of plication surgery with basal approach: when and why -- 17. Corporoplasty: why and when -- 18. Surgical treatment of Peyronie's disease of inflatable penile prosthesis -- 19. Surgical techniques for difficult and complicated cases of Peyronie's disease -- 20. Future perspectives in Peyronie's Disease.
  • Historical review of Peyronie's disease: de la Peyronie to Devine / Emre Akkus -- Epidemiology of Peyronie's disease / Ates Kadioglu and Oner Sanli -- Experimental models for the study of the cellular and molecular pathophysiology of Peyronie's disease / Nestor F. Gonzalez-Cadavid and Jacob Rajfer -- The clinical implications of basic science research in Peyronie's disease / John P. Mulhall -- Evaluation of the man with Peyronie's disease / Jason M. Greenfield and Laurence A. Levine -- Oral treatment of Peyronie's disease / Claudio Teloken, Tulio Graziottin, and Patrick E. Teloken -- Intralesional treatment of Peyronie's disease / Muammer Kendirci, Landon Trost, and Wayne J. G. Hellstrom -- Topical therapy: iontophoresis and electromotive drug administration / Savino M. Di Stasi ... [et al.] -- Topical therapy for Peyronie's disease: ultrasound, laser, gels/creams/solutions / Paul F. Engelhardt and Claus R. Riedl -- Combination nonsurgical therapy / Vincenzo Mirone -- Extracorporeal shockwave therapy in Peyronie's disease / Ekkehard W. Hauck and Wolfgang Weidner -- The Nesbit and plication procedures for Peyronie's disease / David J. Ralph -- Penile plication using the 16-dot technique / Robert C. Dean and Tom F. Lue -- Penile straightening with tunica albuginea plication: TAP procedure / Laurence A. Levine -- Incisional corporoplasty for the correction of Peyronie's disease caused penile curvature / Daniel Yachia -- Peyronie's disease: surgical straightening with tunica plication and tunica transfer / Konstantinos Hatzimouratidis and Dimitrios G. Hatzichristou -- A review of plaque incision with focus on temporalis fascia grafts / Martin Gelbard -- Venous patch graft surgery for Peyronie's disease / Robert C. Dean and Tom F. Lue -- Use of porcine small intestinal submucosal graft in the surgical management of Peyronie's disease / L. Dean Knoll -- Penile straightening with plaque incision or partial excision and human pericardial grafting technique / Laurence A. Levine -- Surgical straightening with tunica incision and grafting technique: single relaxing incision based on geometrical principles / Paulo H. Egydio -- Minimally invasive intracorporal incision of Peyronie's plaque / Anthony J. Bella and Gerald B. Brock -- Surgical straightening with penile prosthesis / Steven K. Wilson and Culley C. Carson, III.
  • "Pfenninger and Fowler's Procedures for Primary Care, 3rd Edition is a comprehensive, "how-to" resource offering step-by-step strategies for nearly every medical procedure that can be performed in an office, hospital, or emergency care facility by primary care clinicians. Designed for everyday practice, the outline format allows speedy reference while the detailed text and clear illustrations guide you through each procedure. The new edition of this best-selling book features full-color illustrations and easy access to the complete contents and illustrations, patient forms, and more online at "--Publisher's website.
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    Avoiding problems with the phacoemulsification machine / William J. Fishkind -- Gas-forced infusion : the solution for surge / Sunita Agarwal -- Mastering the transition to phacoemulsification : avoiding nightmares / Samuel Boyd, Benjamin F. Boyd, Cristela F. Aleman -- Preventing complications using no anesthesia cataract surgery with the karate chop technique / Amar Agarwal -- Using safe horizontal chopping to prevent ruptures / L. Felipe Vejarano, Alejandro Tello -- Principles and paradigms of pediatric cataracts surgery and intraocular lens implantation / Suresh K. Pandey, M. Edward Wilson -- Subluxated cataracts and endocapsular rings / Athiya Agarwal -- Mature cataracts and dyes / Amar Agarwal -- Small pupil phacoemulsification / Amar Agarwal, Soosan Jacob -- Intraoperative floppy iris syndrome / David F. Chang -- Surgical approach to iris reconstruction for iris diaphragm deficiency or dysfunction / Christopher Khng ... [et al.] -- Posterior polar cataracts / Abhay R. Vasavada, Shetal M. Raj -- Combined cataract and glaucoma surgery / Amar Agarwal, Soosan Jacob -- Phacoemulsification and keratoplasty / Javier Mendicute ... [et al.] -- Bimanual phacoemulsification : surgical technique / Amar Agarwal -- Microphakonit / Amar Agarwal -- Complications of bimanual phacoemulsification / Amar Agarwal, Mahipal Singh Sachdev, Clement K. Chan. Phacoemulsification for hyperopia and nanophthalmos / Amar Agarwal, R. Sujatha -- Cataract surgery in dry eye / Suresh K. Pandey, Brighu Swamy, Amar Agarwal -- Phacoemulsification in patients with uveitis / Jorge L. Alio, Herminio Negri -- Refractive cataract surgery / Pandelis Papadopoulos -- Complications of phacoemulsification / L. Felipe Vejarano, Alejandro Tello -- Iatrogenic descemetorhexis as a complication of phacoemulsification / Amar Agarwal ... [et al.] -- Posterior capsular rupture / L. Felipe Vejarano, Alejandro Tello -- Intraocular Lens Power calculation in complex cases / Benjamin F. Boyd, Samuel Boyd, Luis W. Lu -- Posterior capsule opacification / Suresh K. Pandey ... [et al.] -- Intraocular Lens opacification / Suresh K. Pandey, Liliana Werner, David J. Apple -- Managing dislocated lens fragments / Clement K. Chan -- Surgical management of the malpositioned intraocular implant /Clement K. Chan ... [et al.] -- Infectious endophthalmitis / Clement K. Chan, Steven G. Lin -- Cystoid macular edema / Soosan Jacob, Amar Agarwal --
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  • The pharmaceutical industry needs a shot in the arm - and not a moment too soon. The executive suite is mired in a bygone era, a time when extensive, well-funded pharmaceutical R & D produced blockbuster drugs, kept everything in-house and reaped the financial rewards. But that way of working needs to change. Executives now need to know what the technologists in their companies are doing in order to survive the next decade. Written for those new to industry, as well as for experienced professionals or specialists looking to expand their knowledge, this book is a must-read for business executive.
  • This volume examines the effects of natural products and functional/medical foods (nutritional programming) on disease management. It specifically focuses on diseases related to inflammation and immunity, cancer and cachexia, allergies, and brain and neuro/immune. As both pharmacologists and nutritionists are recognizing that the one disease/one target/one drug (or nutrient) concept will be less successful than in the past, this book aims to stress the importance of a multi-target approach versus a single-target approach. It also presents aspects of molecular characteristics of food ingredients toward clinical effectiveness and relevance. The interest in food in health and disease has exploded in the past few years, and publications on the microbiome can be found in all major scientific journals and newspapers. A new concept uses functional foods hand in hand with standard pharmacological therapies, which can be conceptualized in the term 'pharma-nutrition.' With the complementary values of pharma and nutrition, scientists might be able to overcome the increased incidence worldwide of complex multi-factorial disorders, chronic and degenerative diseases in particular.
  • Translational medicine: a paradigm shift in modern drug discovery and development: the role of biomarkers / Mark Day, J. Lynn Rutkowski, and Giora Z. Feuerstein -- Natural products in drug discovery: present status and perspectives / Gabriella Molinari -- Protein pharmaceuticals: discovery and preclinical development / Davinder S. Gill -- The role of nanobiotechnology in drug discovery / Kewal K. Jain -- Conotoxin venom peptide therapeutics / Richard J. Lewis -- Shark novel antigen receptors: the next generation of biologic therapeutics? / Caroline Barelle, Davinder Gill, and Keith Charlton -- Immune interventions of human diseases through toll-like receptors / Cevayir Coban, Ken J. Ishii, and Shizuo Akira -- Genome-based vaccine development: a short cut for the future / Danilo Gomes Moriel ... [et al.] -- The antigenome: from protein subunit vaccines to antibody treatments of bacterial infections? / Carmen Giefing, Eszter Nagy, and Alexander von Gabain -- HSV as a vector in vaccine development and gene therapy / Peggy Marconi ... [et al.] -- Virus-like particles as a vaccine delivery system: myths and facts / Polly Roy and Rob Noad -- Applications of bacterial ghosts in biomedicine / Petra Lubitz, Ulrike Beate Mayr, and Werner Lubitz -- Immune modulators with defined molecular targets: cornerstone to optimize rational vaccine design / Thomas Ebensen and Carlos A. Guzmøn -- Innovative approaches to develop prophylactic and therapeutic vaccines against HIV/AIDS / Aurelio Cafaro ... [et al.] -- New strategies to overcome the drawbacks of currently available flu vaccines / Epifanio Fichera ... [et al.].
  • Introduction to Competitive Intelligence -- Overall Perspective of Due Diligence Investigations and Processes -- The Regulatory Functional Review: Primary Roles -- The On-Site Due Diligence/Data Room Meeting and Interactions with Other Functional Area Experts -- Intellectual Property -- The Final Report -- Competitive Intelligence Summary.
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  • Introduction to experimental design -- Comparison of mean values -- Nonparametric methods -- Regression and correlation -- Multivariate methods -- Factorial design of experiments -- Response-surface methodology -- Model-dependent optimization -- Sequential methods and model-independent optimization -- Experimental designs for mixtures -- Artificial neural networks and experimental design.
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    Strategic project management at the project level / Tony Kennedy -- Strategic project management at the portfolio level / Kevin Bilyard and Des Markland -- Project planning : from basic concepts to systems application / Carl A. Kutzbach, Carole Strong, and Sylvia Walker -- Project management of chemical, analytical, and formulation development / Dieter Krimmer -- Project management in exclusive synthesis / Lukas M.J. von Hippel -- Clinical trials--can they be project managed? / Les Rose -- Regulatory project management / Nicholas Wells -- Teams / Ralph White -- Project management and outsourcing drug development / Jon Court and Mark Fowler -- The project management function / Tony Kennedy.
  • 1. Overview of Medicines Regulatory Systems in the Gulf Region -- 2. The Regulatory Review Process in the Gulf Region -- 3. Regulatory Review Times in the Gulf Region -- 4. Quality Measures in the Gulf Regulatory Practices -- 5. The Current Status of the Common Technical Document -- 6. The Current Status of Drug Safety and Pharmacovigilance -- 7. The Centralized Regulatory Review in the Gulf Region -- 8. The Gulf States Assessment and Experience With the Centralised Procedure -- 9. The Pharmaceutical Companies Assessment and Experience With the Centralised Procedure -- 10. Proposal For an Improved Centralized Regulatory System -- 11. The Strategic Planning Process of the GCC Regulatory Authorities: Barriers And Solutions -- 12. The Regulatory Dilemma in the Gulf Region: The Way Forward.
  • Contains proceedings of the AAPS Stability Workshop.
  • 2007 ProQuest Safari
    Statistics in drug development by Christy Chuang-Stein and Ralph D'Agostino -- Modern classification methods for drug discovery by Kjell Johnson and William Rayens -- Model building techniques in drug discovery by Kimberly Crimin and Thomas Vidmar -- Statistical considerations in analytical method validation by Bruno Boulanger, Viswanath Devanaryan, Walthère Dewé, and Wendell Smith -- Some statistical considerations in nonclinical safety assessment by Wherly Hoffman, Cindy Lee, Alan Chiang, Kevin Guo, and Daniel Ness -- Nonparametric methods in pharmaceutical statistics by Paul Juneau -- Optimal design of experiments in pharmaceutical applications by Valerii Fedorov, Robert Gagnon, Sergei Leonov, and Yuehui Wu -- Analysis of human pharmacokinetic data by Scott Patterson and Brian Smith -- Allocation in randomized clinical trials by Olga Kuznetsova and Anastasia Ivanova -- Sample-size analysis for traditional hypothesis testing: concepts and issues by Ralph G. O'Brien and John Castelloe -- Design and analysis of dose-ranging clinical studies by Alex Dmitrienko, Kathleen Fritsch, Janson Hsu, and Stephen Ruberg -- Analysis of incomplete data by Geert Molenberghs, Caroline Beunckens, Herbert Thijs, Ivy Jansen, Geert Verbeke, Michael Kenward, and Kristen Van Steen -- Reliability and validity: Assessing the psychometric properties of rating scales by Douglas Faries and Ilker Yalcin -- Decision analysis in drug development by Carl-Fredrik Burman, Andy Grieve, and Stephen Senn.
  • Advances in drugs and biologics to mitigate or cure some of nature's most complex medical problems have been incredible to behold. These accomplishments are due to the actions of a wide theatre of participants from biologists, pharmacologists, geneticists, chemists and manufacturers, molecular biologists, toxicologists, clinicians, nurses, program managers, quality assurance personnel, regulatory professionals and a new group of innovators the Imaging Scientists. Imaging has grown from the microscopy sections put on slides with special stains to now in vivo slices created with innovative physics, imaging tracers and contrast agents, and incredibly fast and accurate computational systems. The world of biology has become one of witnessing the actions of drugs and biologics through the window of mechanical and electrical engineering creating instruments and reporter molecules that can help us see into our bodies and paint them with medical information needed to resolve disease. This book will inspire imagination and elicit even more innovations in the development of new and novel drugs and biologics through imaging.
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  • Principles of Cancer Treatment / William G. Newman and Fiona H. Blackhall -- Clinical Pharmacology and Anticancer Drugs / Cristina Rodríguez-Antona and Julia Kirchheiner -- Principles of Genetics and Pharmacogenetics / William G. Newman -- Pharmacogenetics in the Management of Breast Cancer / Sacha J. Howell -- Pharmacogenetics in Colorectal Cancer / Roberta Ferraldeschi -- Pharmacogenetics in Lung Cancer / Fiona Blackhall -- Pharmacogenetics and Cancer Treatment in Children / P. Kellie Turner and Gareth J. Veal -- Pharmacogenetics in Palliative Care / Andrew A. Somogyi -- Genetic Predictors of Normal Tissue Response to Radiotherapy / Catharine M.L. West, Gillian C. Barnett, Alison M. Dunning, Rebecca M. Elliott and Neil G. Burnet -- Cancer Pharmacogenetics in Industry / Mireille Cantarini -- Ethical Issues in Pharmacogenetics / Tara Clancy -- Economics of Cancer Pharmacogenetics / Katherine Payne -- Future Advances in Cancer Pharmacogenomics / William G. Newman.
  • Challenges, opportunities, and evolving landscapes in pharmacogenomics and personalized medicine : an industry perspective / Nadine Cohen and Theresa Frangiosa -- Implementation of pharmacogenomic sample collection in clinical trials / Deborah Sokol Ricci and Monique Franc -- Pharmacogenomics : the regulatory environment and labeling implications / Myong-Jin Kim ... [et al.] -- Applications of pharmacogenomics in drug discovery / Duncan McHale -- Applications of pharmacogenomics in clinical trials / Monique Franc -- Pharmacogenomics applications in drug metabolism : from genotyping to drug label-challenges? / Ann K. Daly -- The genetics of adverse drug reactions : promises and problems / Martin Armstrong -- Strategies and resources for marker selection and genotyping in genetic association studies / Nicole Soranzo, Dong-Jing Fu, and Qingqin S. Li -- Study design and statistical issues in pharmacogenetics research : from candidate genes to genome-wide screens / Nicholas J. Schork, Nathalie Malo, and Eric J. Topol -- Holy SNP, Batman! / Reyna Favis -- Predictive biomarker classifiers in the design of pivotal clinical trials / Richard Simon -- Translation of biomarkers into clinical utility / William L. Trepicchio and George Mulligan -- Pharmacogenomic study feasibility assessment and pharmaceutical business decision-making / Monique Franc and Theresa Frangiosa -- Co-development of drugs and pharmacogenomics-based diagnostics in oncology / Jeffrey S. Ross -- Pharmacogenomics applications in epilepsy / Chantal Depondt -- Pharmacogenomics in Alzheimer's disease / Ramón Cacabelos -- Pharmacogenomics applications in psychiatric disorders / Todd Lencz and Anil K. Malhotra -- Pharmacogenomics in HIV disease / Amalio Telenti -- Pharmacogenomics and cardiovascular drugs / Gérard Siest ... [et al.] -- Pharmacogenomic applications in children / Susan F.A. Grant and Hakon Hakonarson -- Pharmacogenomics of rare and monogenic disorders / Paul D. Maher.
  • Pharmacogenomics principles : introduction to personalized medicine / Parvaz Madadi, and Gideon Koren -- Traditional therapeutic drug monitoring and pharmacogenomics : are they complementary? / Christine Snozek, Loralie J. Langman, and Amitava Dasgupta -- Pharmacogenomics aspect of warfarin therapy / Matthew D. Krasowski -- Pharmacogenetics and cancer chemotherapy / Christine L.H. Snozek -- Pharmacogenomic considerations in anesthesia and pain management / Christine Formea, Wayne T. Nicholson -- Pharmacogenomics of immunosuppressants / Nicolas Picard and Pierre Marquet -- Pharmacogenomics of cardiovascular drugs / Linnea M. Baudhuin -- Pharmacogenomics aspect of antiretroviral therapy / Natella Y. Rakhmanina and John N. van den Anker -- Pharmacogenetics of psychoactive drugs / Jorge L. Sepulveda -- Pharmacogenomic aspects of adverse drug-drug interactions / Loralie J. Langman and Christine Snozek -- Microarray technology and other methods in pharmacogenomics testing / Jorge L. Sepulveda -- Pharmacogenetic testing in the clinical laboratory environment / Mark P. Borgman and Mark W. Linder.
  • One tablet or two? : towards the development of pharmacogenomically informed drug dose individualization / Kirchheiner, J. ... [et al.] -- Pharmacogenomics : reflecting on the old and new social, ethical and policy issues in postgenomics medicine / Ozdemir, V. -- Pharmacogenomics and personality : role of CYP2D6 and implications for psychopathology / Peñas-LLedó, E.M.; Dorado, P.; Llerena, A. -- Pharmacogenetics of schizophrenia : bringing 'order to chaos' in the psychopharmacology of schizophrenia? / Buckley, P.F.; Miller, D.D.; Foster, A. -- Pharmacogenomics of depression / Serretti, A.; Drago, A.; Spina, E. -- Pharmacogenomics of attention-deficit/hyperactivity disorder / Froehlich, T.; Stein, M.A. -- Pharmacogenomics of eating disorders / Monteleone, P.; Maj, M. -- Future of personalized prescription in psychiatry / de Leon, J.
  • Pharmacogenomics : historical perspective and current status / Rosane Charlab and Lei Zhang -- Denaturing high-performance liquid chromatography for mutation detection and genotyping / Donna Lee Fackenthal [and others] -- Clinical SNP detection by the smartAmp method / Toshihisa Ishikawa and Yoshihide Hayashizaki -- MALDI-TOF mass spectrometry / Dirk van den Boom, Matthias Wjst, and Robin E. Everts -- TaqMan® drug metabolism genotyping assays for the detection of human polymorphisms involved in drug metabolism / Toinette Hartshorne -- Pyrosequencing of clinically relevant polymorphisms / Cristi R. King and Sharon Marsh -- Pharmacogenetics using Luminex® xMAP® technology : a method for developing a custom multiplex single nucleotide polymorphism mutation assay / Gonnie Spierings and Sherry A. Dunbar -- Use of linkage analysis, genome-eide association studies, and next-generation sequencing in the identification of disease-causing mutations / Eric Londin [and others] -- GoldenGate genotyping assay : custom design, processing, and data analysis / Anna González-Neira -- Genome-wide gene expression profiling, genotyping, and copy number analyses of acute myeloid leukemia using affymetrix geneChips. / Mathijs A. Sanders and Peter J.M. Valk -- Epigenetic techniques in pharmacogenetics / Sandra G. Heil -- Plasmid derived external quality controls for genetic testing / Tahar van der Straaten and Henk-Jan Guchelaar -- Allelic imbalance assays to quantify allele-specific gene expression and transcription factor binding / Francesca Luca and Anna Di Rienzo -- SCAN : a systems biology approach to pharmacogenomic discovery / Eric R. Gamazon, R. Stephanie Huang, and Nancy J. Cox -- Methods to examine the impact of nonsynonymous SNPs on protein degradation and function of human ABC transporter / Toshihisa Ishikawa, Kanako Wakabayashi-Nakao, and Hiroshi Nakagawa -- In vitro identification of cytochrome P450 enzymes responsible for drug metabolism / Zhengyin Yan and Gary W. Caldwell -- In vitro and in vivo mouse models for pharmacogenetic studies / Amber Frick [and others] -- Hydrodynamic tail vein assay as a tool for the study of liver promoters and enhancers / Mee J. Kim and Nadav Ahituv -- Guide to the current web-based resources in pharmacogenomics / Dylan M. Glubb [and others] -- PharmGKB : the pharmacogenomics knowledge base / Caroline F. Thorn, Teri E. Klein, and Russ B. Altman -- Genetic databases in pharmacogenomics : the frequency of inherited disorders database (FINDbase) / Marianthi Georgitsi and George P. Patrinos -- Development of predictive models for estimating warfarin maintenance dose based on genetic and clinical factors / Lu Yang and Mark W. Linder -- Evidence based drug dosing and pharmacotherapeutic recommendations per genotype / Vera H.M. Deneer and Ron H.N. van Schaik.
  • Ch. 1. Pharmacogenomics principles of alcohol and DOA / Christine L.H. Snozek and Loralie J. Langman -- ch. 2. Alcohol : use and abuse / Amitava Dasgupta -- ch. 3. Slate and trait makers of alcohol abuse / Joshua Bornhorst ... [et al.] -- ch. 4. Introduction to drugs of abuse / Larry Broussard and Catherine Hammett-Stabler -- ch. 5. Pharmacogenomics of amphetamine and related drugs / Steven C. Kazmierczak -- ch. 6. Pharmacogenomics of cocaine / Loralie J. Langman and Christine L.H. Snozek -- ch. 7. Genetic aspect of marijuana metabolism and abuse / Pradip Datta -- ch. 8. Genetic aspect of opiate metabolism and addiction / Jorge L. Sepulveda -- ch. 9. Pharmacogenomics aspects of addiction treatment / F. Gerard Moeller -- ch. 10. Methodologies in pharmacogenetics testing / Jorge L. Sepulveda.
  • Historical aspects of pharmacogenetics / Werner Kalow -- Pharmacogenomics and the promise of personalized medicine / Vural Ozdemir and Bernard Lerer -- Pharmacogenetics of drug metabolism: two clinically important polymorphic enzymes, CYP2D6 and TPMT / Georgios Panagiotidis and Leif Bertilsson -- Receptors / Wendell W. Weber -- Pharmacogenetics of drug transporters / Catia Marzolini, Rommel G. Tirona, and Richard B. Kim -- Variability in induction of human drug metabolizing enzymes / Allan B. Okey -- Pharmacogenetics and cardiac ion channels / Dan M. Roden -- Interethnic differences in drug response / Werner Kalow -- Clinical perspectives / Urs A. Meyer and David A. Flockhart -- Regulatory perspectives on pharmacogenomics / Lawrence J. Lesko and Janet Woodcock -- Tools of the trade: the technologies and challenges of pharmacogenetics / Glenn A. Miller -- Technologies for the analysis of single nucleotide polymorphisms - an overview / Denis M. Grant -- Molecular diagnostics / Tracy L. Stockley and Peter N. Ray --
  • ch. 1. Physicochemistry -- ch. 2. Pharmacokinetics -- ch. 3. Absorption -- ch. 4. Distribution -- ch. 5. Clearance -- ch. 6 Renal clearance -- ch. 7. Metabolic (hepatic) clearance -- ch. 8. Toxicity -- ch. 9. Inter-species -- ch. 10. High(er) throughput ADME studies.
  • SECTION I. Basic Principles -- Chapter 1. Basic Principles / Ronald D. Schoenwald -- SECTION II. Industrial and Regulatory Applications -- Chapter 2. PK/PD Approach / Honghui Zhou -- Chapter 3. Pharmacokinetics and Metabolism in Drug Discovery and Preclinical Development / Nishit B. Modi -- Chapter 4. Phase I, II, and III FDA Submissions / Mark G. Eller -- Chapter 5. Bioavailability and Bioequivalence / Veneeta Tandon -- SECTION III. Clinical Applications -- Chapter 6. General Approaches to Clinical Pharmacokinetic Monitoring / Ronald A. Herman -- Chapter 7. Aminoglycosides and Other Antibiotics / Michael E. Klepser and Erika J. Ernst -- Chapter 8. Cardiovascular Agents / John M. Dopp and Bradley G. Phillips -- Chapter 9. Psychotropic Agents / Paul J. Perry -- Chapter 10. Theophylline / Bernd Meibohm -- Chapter 11. Anticonvulsant Agents / Gail D. Anderson -- SECTION IV. Research Applications -- Chapter 12. Classical Modeling / David W A. Bourne -- Chapter 13. Noncompartmental Modeling: An Overview / Ronald A. Herman -- Chapter 14. Physiologically Based Pharmacokinetic Models / James M. Gallo -- Chapter 15. Population Pharmacokinetics / Jeffrey S. Barrett -- Chapter 16. The Linear Systems Approach / Peter Veng-Pedersen -- Index.
  • What next in colorectal cancer? / James Cassidy -- Pathophysiology and drug targets in metastatic colorectal cancer / Autumn McRee & Howard L. McLeod -- First-line chemotherapy / Yoko Yanagisawa, Rachel Midgley & David Kerr -- Monoclonal antibodies / Giuseppe Tonini, Marco Imperatori, Alice Zoccoli, Michele Iuliani & Francesco Pantano -- Drugs in clinical trials / Irene Braña, Rodrigo Dienstmann, Jaume Capdevila & Josep Tabernero -- Which therapy for which patient? / Patryk Kambakamba, Stefan Breitenstein, Panagiotis Samaras, Paul Magnus Schneider & Georg Lurje.
  • This book is the 4th in a series of Acute Care books written with the aim to address the NEEDS of health care providers when handling the acutely ill patients. Globally it has become apparent that the study of pharmacology and subsequent clinical training has not always adequately equipped young doctors with the ability to administer drugs to their patients safely and confidently, particularly in the critically ill patient. Compounding this issue is the lack of resource material related to these pharmacological concepts contained in one book that can help health care providers to understand and manage drug therapy in the acute situation. In spite of progressively newer and more developed protocols, guidelines, algorithms and many other books addressing the technical aspects of what needs to be done, most health care providers still find it difficult to grasp the basic pharmacological knowledge and rationally deliver the CARE that is required in the acute phase of patient management. The editors/authors have therefore aimed for a book that highlights topics and pharmacological issues pertinent to management of patients in their hour of need. This is a multi-author book but the style has been guided by 3 editors. The editors have used a different perspective? that of normalizing abnormal physiological processes with pharmacological agents? to address the GAPS in a bedside to bench approach. The details are pared down but important principles/concepts are emphasized.
  • The natural world with a large number of terrestrial and marine plants and lower organisms is a great source of bioactive compounds historically used as remedies in various diseases. Within the last decade, such compounds became more attractive targets for pharmacologists and the pharmaceutical industry in drug development projects. This volume presents the pharmacological potential of chemically defined natural compounds obtained from plants, fungi, algae and cyanobacteria with antiparasitic activity, that have been tested against various endo-parasitic protozoan and helminth species. --Source other than Library of Congress.
  • Cardiovascular pharmacotherapy is a fast-moving and complex discipline within cardiology in general. New studies, trials and indications are appearing on a regular basis. This series, and this particular title within the series, is designed to establish the baseline level of knowledge that a cardiovascular professional needs to know on a day-to-day basis. The information within is designed to allow readers to learn quickly and with certainty the mode of action, the possible adverse effects, and the management of patients prescribed these drugs.
  • This book describes the clinical challenge currently posed by stable angina pectoris and provides guidance for those making clinical decisions regarding its pharmacological treatment. The importance of providing effective treatment is beyond dispute and this book deals with the most relevant aspects related to its pharmacological treatment. The pathogenesis of myocardial ischemia as the basis for rational treatment of angina is discussed thoroughly together with all major management goals including optimal symptom control and the secondary prevention of serious cardiovascular events. Pharmacological Treatment of Chronic Stable Angina Pectoris provides a clear description of the mechanisms of action and clinical indications of available anti-angina drugs and strategies for the use of novel pharmacological agents. It also includes a critical appraisal of the major management guidelines, which will assist the reader to interpret current evidence and provide the most appropriate forms of treatment. The ongoing controversy regarding medical therapy versus myocardial revascularization for the management of stable angina pectoris is also addressed. This eminently practical book will help guiding the reader through the complexities of the field and will be highly appreciated by clinicians, clinical cardiologists and cardiology trainees alike.
  • Pharmacological treatments in schizophrenia / Matcheri S. Keshavan -- Pathophysiology of psychotic disorders and the need for novel therapeutic targets / Matcheri S. Keshavan -- Current standard treatments / Joseph McEvoy -- Unmet medical needs in schizophrenia treatments / Mujeeb U. Shad -- Novel approaches for treating schizophrenia / Michael C. Davis & Stephen R. Marder -- Novel long-acting and extended-release formulations of antipsychotic drugs / Larry Alphs -- Future directions in the treatment of schizophrenia / Rajiv Tandon -- Index.
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    Pharmacokinetics and pharmacodynamics of injected and inhaled drugs -- Inhaled anesthetics -- Opioid agonists and antagonists -- Barbiturates -- Benzodiazepines -- Nonbarbiturate intravenous anesthetic drugs -- Local anesthetics -- Neuromuscular-blocking drugs -- Anticholinesterase drugs and cholinergic agonists -- Anticholinergic drugs -- Cyclooxygenase-2 inhibitors and nonspecific nonsteroidal antiinflammatory drugs -- Sympathomimetics -- Digitalis and related drugs -- Alpha- and beta-adrenergic receptor antagonists -- Antihypertensive drugs -- Peripheral vasodilators, nitric oxide, and nitrovasodilators -- Cardiac antidysrhythmic drugs -- Calcium-channel blockers -- Drugs used for psychopharmacologic therapy -- Prostaglandins -- Histamine and histamine receptor-antagonists -- Serotonin, plasma kinins, and renin -- Hormones as drugs -- Insulin and oral hypoglycemics -- Diuretics -- Antacids and gastrointestinal prokinetics -- Anticoagulants -- Antimicrobials -- Chemotherapeutic drugs -- Antiepileptic drugs -- Antiepileptic drugs -- Drugs used for treatment of parkinson disease -- Drug treatment of lipid disorders -- Central nervous system stimulants and muscle relaxants -- Vitamins, dietary supplements, and herbal remedies -- Minerals and electrolytes -- Blood components, substitutes and hemostatic drugs -- Enteral and parenteral nutrition -- Antiseptics and disinfectants -- Cell structure and function -- Body fluids -- Central nervous system -- Thermoregulation -- Autonomic nervous system -- Pain -- Systemic circulation -- Microcirculation and lymphatics -- Pulmonary circulation -- Heart -- The electrocardiogram and analysis of cardiac dysrhythmias -- The lungs -- Pulmonary gas exchange and blood transport of gases -- Acid-base balance -- Endocrine system -- Kidneys -- Liver and gastrointestinal tract -- Skeletal and smooth muscle -- Erythrocytes and leukocytes -- Hemostasis and blood coagulation -- Metabolism of nutrients -- Physiology of the newborn and elderly.
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  • Pharmacology -- Pharmacokinetic Principles -- Introduction to Specialist Therapeutics.
  • 2013 ClinicalKey
    "Better understand the complexities of pharmacology and physiology relevant to your practice with the brand-new medical reference book, Anesthetic Pharmacology and Physiology. Drs. Hugh Hemmings and Talmage Egan provide the clinical insights you need to effectively administer anesthesia, ensuring patient safety and the most optimal outcomes. Access comprehensive, continually updated research on the physiology of organ systems and clinical topics in the pharmacology of anesthetic drugs. Quickly and easily reference the information you need through user-friendly tables, figures, and algorithms, all presented in lavish full color throughout. Understand the molecular mechanism of drug actions and identify key drug interactions that may complicate anesthesia with dedicated sections on these key areas"--Provided by publisher.
  • Everything you need to know about all of today's drugs in a coherent, easy-to-use format - from the underlying science through innovation, translation, regulation, and clinical implementation. This multimedia resource fills a critical need for a more clinically focused, user-friendly pharmacology reference. Evidence-based therapeutic guidelines facilitate decision making; and coverage of pharmacogenetics and pharmacogenomics, regenerative pharmacology, stem cell therapies, and the emerging field of individualized medicine keeps you at the forefront of the latest developments.
  • The double page spreads in this book each cover a discrete topic and broadly correspond to the chapters of the main textbook 'Pharmacology' by Rang et al. Each spread includes at least one summary diagram and a small amount of text plus a 'clinical use' box.
  • Chapter 1. Pharmacology: The Chemical Control of Physiology -- Chapter 2. Drug Affinity and Efficacy -- Chapter 3. Predicting Agonist Effect -- Chapter 4. Drug Antagonism: Orthosteric Drug Effects -- Chapter 5. Allosteric Drug Effects -- Chapter 6. Enzymes as Drug Targets -- Chapter 7. Pharmacokinetics I: Permeation and Metabolism -- Chapter 8. Pharmacokinetics II: Distribution and Multiple Dosing -- Chapter 9. In Vivo Pharmacology -- Chapter 10. Safety Pharmacology -- Chapter 11. Answers to Chapter Questions -- Chapter 12. Derivations and Proofs.
  • "This work is the first monograph devoted solely to Bombax ceiba, popularly known as the Red Silk Cotton Tree. Consisting of seven chapters, it covers all relevant aspects of this plant, from its historical and spiritual importance, to its botanical characterization, pharmacognostical details and ethnobiological uses, to its scientific validation in various animal and human studies. Each part of the tree is of medicinal value and possesses many novel chemical constituents such as shamimicin, bombasin, bombamalone, bombamaloside etc. along with other bioactive secondary metabolites. The book presents the chemical structures of the most important constituents and highlights various pharmacological activities, predominantly antioxidant, anti-inflammatory, anti-mutagenic, hypoglycemic, hypotensive, hepatoprotective and fibrinolytic, which may prove to be a source for the development of a novel phyto-pharmaceutical agent to treat diabetes, heart disease and cancer. In addition, separate chapters deal with the commercial and ecological significance of B. ceiba, as well as a case study on its conservation. Numerous color illustrations are included to identify the plant and to justify its nickname, the “Little Bird's Cafeteria”."--Publisher's website.
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    General principles -- The peripheral nervous systems: autonomic and somatic -- The central nervous system -- The cardiovascular system -- The renal system and diuretics -- The respiratory system: asthma and COPD -- Local control substances: autacoids and drugs for inflammatory processes -- The gastrointestinal system and nutrition -- The endocrine system, uterine stimulants, and relaxants -- Anti-infectives -- Cancer chemotherapy and immunosuppressants -- Toxicology.
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    General Principles of Pharmacology -- The Peripheral Nervous System: Autonomic and Somatic Nervous System Pharmacology -- Central Nervous System Pharmacology -- Cardiovascular Pharmacology -- Renal System and Diuretics Pharmacology -- Respiratory System Pharmacology: Asthma and COPD -- Autacoids and Anti-Inflammatory Pharmacology -- Gastrointestinal and Urinary Tract Pharmacology, Nutrition (Vitamins) -- Endocrine Pharmacology, Uterine Stimulants and Relaxants -- Antimicrobial and Antiviral Pharmacology -- Cancer and Immune System Pharmacology -- Toxicology, Bioterrorism, and Chemical Warfare Agents.
  • What is pharmacology? -- How different tissues process drug response -- Drug-receptor theory -- Pharmacological assay formats : binding -- Agonists : the measurement of affinity and efficacy in functional assays -- Orthosteric drug antagonism -- Allosteric drug antagonism -- The process of drug discovery -- Pharmacokinetics -- Target- and system-based strategies for drug discovery -- "Hit" to drug : lead optimization -- Statistics and experimental design -- Selected pharmacological methods -- Exercises in pharmacodynamics and pharmacokinetics.
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    Adverse drug reaction icons -- Pharmacology basics -- Antimicrobial drugs -- Autonomic drugs -- Cancer chemotherapeutics -- Cardiovascular drugs -- Central nervous system drugs -- Endocrine drugs -- Gastrointestinal drugs -- Hematological drugs -- Immune response modifiers -- Renal and urological drugs -- Respiratory drugs -- Appendix A. Tricks for remembering drug names.
  • "Pharmacology: An Illustrated Review covers the facts and concepts you must master for classroom and USMLE success--as well as key knowledge for daily clinical practice. Thieme's new illustrated Review Series serves an important dual purpose for medical students--both concise course review and high-yield USMLE test preparation. Covering all the basic science subjects that you will take in medical school and that will be found on the USMLE Step 1, the series features unparalleled color illustrations, a streamlined format, and hundreds of print and online study questions and answers--all designed to increase your mastery of the topic, promote classroom success, and boost your confidence for the exam! Combining targeted reviews of the basic sciences with a multitude of exam questions for easy reinforcement and retention, these efficient-to-study books put success at your fingertips"--Provided by publisher.
  • Pharmacology. 4th ed. 2013
    Pharmacology, 4th Edition helps you master the "must-know" concepts in this subject and how they apply to everyday clinical problem solving and decision making. This concise yet comprehensive text clearly explains and illustrates challenging concepts and helps you retain the material - from course exams and the USMLE Step 1 right through to clinical practice. Quickly reference essential information thanks to abundant tables throughout, and drug classification boxes at the beginning of each chapter. See how pharmacology applies to practice with real-world case studies. Prepare for exams with self-assessment questions at the end of each chapter. Understand complex concepts visually with the aid of superb full-color illustrations. Access the complete contents online at, along with an additional glossary, chapter-by-chapter summaries and case studies, a full list of featured drugs, 150 USMLE-style questions, animations, and more.
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  • Although more than 10 new antiepileptic drugs have been developed in the past decade, epilepsy remains resistant to drug therapy in about one-third of patients, many of whom struggle with the disease their entire lives. Managing these patients is a challenge and requires a structured multidisciplinary approach. The book includes chapters on all issues related to pharmacoresistance in epilepsy, and describes recent developments in the pathogenesis and treatment of this disorder. It addresses abnormalities in inhibitory mechanisms, epilepsy-related changes to the immune system, development of pharmacoresistance caused by chronic exposure to antiepileptic drugs, and novel therapeutic strategies for preventing or slowing down the progression of the disease. Clinicians and basic scientists alike will find up-to-date information on the development of pharmacoresistance, as well as reviews of mechanisms associated with epilepsy that may help them consider novel strategies for preventing the development of pharmacoresistance in the first place. The book also features information on new therapeutic strategies for control of epilepsy, such as transcutaneous electrical stimulation and virtual screening of new antiepileptic drugs. Pharmacoresistance in Epilepsy: From Genes and Molecules to Promising Therapies is useful to anyone working in the field, whether they're studying epilepsy in the lab or treating it in a doctor's office.
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  • This book is driven by the considerable progress made by novel imaging techniques in understanding the pathophysiology and evolution of aortic disease and its diagnosis. Despite the lack of symptoms in stable conditions, most aortic diseases have a high morbidity and mortality. New therapeutic strategies such as endovascular treatment and surgical techniques have appeared to improve conventional surgery in advanced phases of the disease, but until recently, medical treatment has focused on the control of cardiovascular risk factors using beta-blockers to reduce aortic wall stress by reducing blood pressure and heart rate. Pharmacotherapy in Aortic Disease updates the reader on the new medical treatment that are changing the natural history of these diseases. Leading experts have created a critical in-depth, yet concise, analysis of the available medical treatments for different aortic disease entities. Both basic research studies and clinical trials discussed in this book serve as a base for improving therapeutic management, delaying the need for surgery, and prolonging survival in these patients.
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  • Pharmacoepidemiology of diabetes -- New definitions of diabetes: consequences -- The insulin resistance syndrome: concept and therapeutic approaches -- Medical emergencies-diabetic ketoacidosis and hyperosmolar hyperglycaemia -- Notes on the use of glucagon in type 1 diabetes -- Insulin and new insulin analogues, insulin pumps and inhaled insulin in type 1 diabetes -- Insulin and new insulin analogues with focus on type 2 diabetes -- The place of insulin secretagogues in the treatment of type 2 diabetes in the twenty-first century -- Metformin-from devil to angel -- The glitazones, lessons so far -- Antidiabetic combination therapy -- The incretin modulators-incretin mimetics (GLP-1 receptor agonists) and incretin enhancers (DPP-4 inhibitors) -- The role of alpha-glucosidase inhibitors (acarbose) -- Multifactorial intervention in type 2 diabetes -- Obesity and pharmacological treatment -- Management of diabetic dyslipidaemia -- Coronary intervention and ischemic cardioprotection in diabetic patients -- ACE-I and ARB and blood pressure lowering, including effect on renal disease. Treatment of advanced diabetic renal disease -- Aspirin and antiplatelet drugs in the prevention of cardiovascular complications of diabetes -- Glycosylation inhibitors, PKC inhibitors and related interventions against complications -- Diabetic foot ulcers -- Pharmacotherapy in diabetic neuropathy -- Pregnancy-pharmacological problems - Pharmacotherapy of diabetic retinopathy -- Pharmacotherapy in diabetic sexual dysfunction -- A bone perspective -- Achieving guideline control with new pharmacotherapies; albumin-binding by acylation of insulin and GLP-1 -- Pharmacotherapy of diabetes.
  • Definition and classification of pulmonary hypertension / Marc Humbert, David Montani, Oleg V. Evgenov, and Gérald Simonneau -- Pulmonary hypertension: pathophysiology and signaling pathways / Bradley A. Maron and Joseph Loscalzo -- Pulmonary hypertension: pathology / Peter Dorfmüller -- Pulmonary hypertension: biomarkers / Christopher J. Rhodes, John Wharton, and Martin R. Wilkins -- Rodent models of group 1 pulmonary hypertension / John J. Ryan, Glenn Marsboom, and Stephen L. Archer -- General supportive care / Ioana R. Preston -- Calcium-channel blockers in pulmonary arterial hypertension / Marie-Camille Chaumais, Elise Artaud Macari, and Olivier Sitbon -- Prostacyclins / Horst Olschewski -- Endothelin Receptor Antagonists / Martine Clozel, Alessandro Maresta, and Marc Humbert -- Phosphodiesterase-5 inhibitors / Barbara A. Cockrill and Aaron B. Waxman -- Inhaled nitric oxide for the treatment of pulmonary arterial hypertension / Steven H. Abman -- Soluble guanylate cyclase stimulators in pulmonary hypertension / Johannes-Peter Stasch and Oleg V. Evgenov -- Therapeutics targeting of dysregulated redox equilibrium and endothelial dysfunction / Michael G. Risbano and Mark T. Gladwin -- Rho-kinase inhibitors / Yoshihiro Fukumoto and Hiroaki Shimokawa -- Serotonin transporter and serotonin receptors / Serge Adnot, Amal Houssaini, Shariq Abid, Elisabeth Marcos, and Valérie Amsellem -- Targeting of platelet-derived growth factor signaling in pulmonary arterial hypertension / Eva Berghausen, Henrik ten Freyhaus, and Stephan Rosenkranz -- Emerging molecular targets for anti-proliferative strategies in pulmonary arterial hypertension / Ly Tu and Christophe Guignabert -- Anti-inflammatory and immunosuppressive agents in PAH / Jolyane Meloche, Sébastien Renard, Steeve Provencher, and Sébastien Bonnet -- Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application / Reshma S. Baliga, Raymond J. MacAllister, and Adrian J. Hobbs -- Pulmonary hypertension: novel pathways and emerging therapies inhibitors of cGMP and cAMP metabolism / Yassine Sassi and Jean-Sébastien Hulot -- Pulmonary hypertension: old targets revisited (statins, PPARs, beta-blockers) / Geoffrey Watson, Eduardo Oliver, Lan Zhao, and Martin R. Wilkins -- Pulmonary hypertension: current management and future directions / Lewis J. Rubin.
  • Pharmacy Practice Research- Evidence and Impact -- Research Methodologies related to pharmacy practice: An Overview -- Quantitative Methods in Pharmacy Practice Research -- Qualitative Methods in Pharmacy Practice Research -- Action Research in Pharmacy Practice -- Participatory Action Research in Pharmacy Practice -- Mixed Methods Research in Pharmacy Practice -- Applying organizational theory in Pharmacy Practice Research -- Applying pharmacoeconomic methods in community and hospital pharmacy research -- Concept Mapping and pattern matching in pharmacy practice research -- Pharmacoepidemiological approaches in healthcare -- Future of Pharmacy Practice Research -- Pharmacists' attitudes towards pharmacy practice research: a review.
  • pt. 1. Foundations of phase response analysis -- pt. 2. Estimation of phase response curves -- pt. 3. Cellular mechanisms of neuronal phase response properties -- pt. 4. Prediction of network activity with phase response curves.
  • Learn the most up-to-date information on materials used in the dental office and laboratory today. Emphasizing practical, clinical use, as well as the physical, chemical, and biological properties of materials, this leading reference helps you stay current in this very important area of dentistry. This new full-color edition also features an extensive collection of new clinical photographs to better illustrate the topics and concepts discussed in each chapter. Organization of chapters and content into four parts (General Classes and Properties of Dental Materials; Auxiliary Dental Materials; Direct Restorative Materials; and Indirect Restorative Materials) presents the material in a logical and effective way for better comprehension and readability. Balance between materials science and manipulation bridges the gap of knowledge between dentists and lab technicians. Major emphasis on biocompatibility serves as a useful guide for clinicians and educators on material safety. Distinguished contributor pool lends credibility and experience to each topic discussed. Critical thinking questions appearing in boxes throughout each chapter stimulate thinking and encourage classroom discussion of key concepts and principles. Key terms presented at the beginning of each chapter helps familiarize readers with key terms so you may better comprehend text material.
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    An exploration of the philosophical foundation of modern medicine which explains why such a medicine possesses the characteristics it does and where precisely its strengths as well as its weaknesses lie. Written in plain English, it should be accessible to anyone who is intellectually curious, lay-persons, and medical professionals alike. --From publisher description.
  • Philosophical practice 2002
  • Philosophy of medicine 2011
    This volume covers a wide range of conceptual, epistemological and methodological issues in the philosophy of science raised by reflection upon medical science and practice. Several chapters examine such general meta-scientific concepts as discovery, reduction, theories and models, causal inference and scientific realism as they apply to medicine or medical science in particular. Some discuss important concepts specific to medicine (diagnosis, health, disease, brain death). A topic such as evidence, for instance, is examined at a variety of levels, from social mechanisms for guiding evidence-based reasoning such as evidence-based medicine, consensus conferences, and clinical trials, to the more abstract analysis of experimentation, inference and uncertainty. Some chapters reflect on particular domains of medicine, including psychiatry, public health, and nursing. The contributions span a broad range of detailed cases from the science and practice of medicine, as well as a broad range of intellectual approaches, from conceptual analysis to detailed examinations of particular scientific papers or historical episodes. Chapters view philosophy of medicine from quite different angles Considers substantive cases from both medical science and practice Chapters from a distinguished array of contributors.
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    Examining stem cell biology from a philosophy of science perspective, this book clarifies the field's central concept, the stem cell, as well as its aims, methods, models, explanations and evidential challenges. The first chapters discuss what stem cells are, how experiments identify them, and why these two issues cannot be completely separated. The basic concepts, methods and structure of the field are set out, as well as key limitations and challenges. The second part of the book shows how rigorous explanations emerge from stem cell experiments, and compares these to other kinds of scientific explanation. Model organisms, the role of genes, and the significance of collaboration are also discussed. The last part of the book considers relations to systems biology and clinical medicine, arguing that both the mathematical models of the former, and ethical principles of the latter, are necessary for stem cell biology to deliver on its promises.
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  • The management of venous pathology has been revolutionized by technological advancements. Venous disease is now managed with a wide variety of techniques that collectively allow physicians to diagnose and treat venous problems in ways that few surgeons would have anticipated even a decade ago. Techniques include laser ablation, radiofrequency ablation, chemical ablation (sclerotherapy), high ligation with or without stripping, ambulatory phlebectomy, powered phlebectomy, subfascial endoscopic perforator surgery, three-dimensional venography, and intravascular ultrasound. All of these topics are covered in this comprehensive, up-to-date textbook, which guides the practitioner through every aspect of care of the venous patient and includes essential background information on anatomy and pathophysiology. This book is exceptional in that it is based entirely on the curriculum designed for board certification by the American College of Phlebology (ACP). A further unique aspect of the text is the integration of ultrasound and various other imaging modalities, that play a fundamental role in diagnosis and management. The authors come from a wide range of specialties, mirroring the diversity of practitioners who care for patients with venous disease. The book will accordingly serve the needs of vascular and general surgeons, interventional radiologists, phlebologists, nurses, ultrasonographers, allied health professionals, and scientists, as well as American College of Phlebology fellowship candidates and those preparing for board examinations in vascular surgery.
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  • Osteo-renal cross-talk and phosphate metabolism by the FGF23-klotho system / Ohnishi, M., Razzaque, M.S. -- Extracellular phosphate as a signaling molecule / Michigami, T. -- Complex regulation and diverse functions of alpha-klotho / Maeda, R., Imura, A., Nabeshima, Y. -- Klotho and chronic kidney disease / Hu, M.C., Kuro-o, M., Moe, O.W. -- Nuclear receptor LXR : a new partner for sodium-dependent phosphate cotransporters / Caldas, Y., Giral, H., Sorribas, V., Levi, M. -- Phosphate toxicity and vascular mineralization / Razzaque, M.S. -- Vitamin D and type II sodium-dependent phosphate cotransporters / Kido, S., Kaneko, I., Tatsumi, S., Segawa, H., Miyamoto, K. -- Vitamin D in chronic kidney disease / Li, Y.C. -- Parathyroid function in chronic kidney disease : role of FGF23-klotho axis / Koizumi, M., Komaba, H., Fukagawa, M. -- FGF23-induced hypophosphatemia persists in Hyp mice deficient in the WNT coreceptor Lrp6 / Uchihashi, K., Nakatani, T., Goetz, R., Mohammadi M., He, X., Razzaque, M.S. -- Can salivary phosphate levels be an early biomarker to monitor the evolvement of obesity? / Hartman, M.-L., Groppo, F., Ohnishi, M., Goodson, J.M., Hasturk, H., Tavares, M., Yaskell, T., Floros, C., Behbehani, K., Razzaque, M.S.
  • A high-resolution two dimensional gel- and pro-Q DPS-based proteomics workflow for phosphoprotein identification and quantitative profiling / Ganesh K. Agrawal and Jay J. Thelen -- Differential phosphoprotein labelling (DIPPL) using ³²P and ³³P / Aviva M. Tolkovsky and Andreas Wyttenbach -- Identification of oxidative stress-induced tyrosine phosphorylated proteins by immunoprecipitation and mass spectrometry / Ma Carmen Duran, Hong-Lin Chan, and John F. Timms -- Enrichment and characterization of phosphopeptides by immobilized metal affinity chromatography (IMAC) and mass spectrometry / Tine E. Thingholm and Ole N. Jensen -- The use of titanium dioxide micro-columns to selectively isolate phosphopeptides from proteolytic digests / Tine E. Thingholm and Martin R. Larsen -- Enrichment and separation of mono- and multiply phosphorylated peptides using sequential elution from IMAC prior to mass spectrometric analysis / Tine E. Thingholm , Ole N. Jensen, and Martin R. Larsen -- Use of stable isotope labeling by amino acids in cell culture (SILAC) for phophotyrosine protein identification and quantitation / Guoan Zhang and Thomas A. Neubert -- Hydrophilic interaction chromatography for fractionation and enrichment of the phosphoproteome / Dean E. McNulty and Roland S. Annan -- SILAC for global phosphoproteomic analysis / Genaro Pimienta, Raghothama Chaerkady, and Akhilesh Pandey -- Quantitative phospho-proteomics based on soluble nanopolymers / Anton Iliuk and W. Andy Tao -- Profiling the tyrosine phosphorylation state using SH2 domains / Kevin Dierck ... [et al.] -- An overview of the qualitative analysis of phosphoproteins by mass spectrometry / Philip R. Gafken -- The analysis of phosphoproteomes by selective labelling and advanced mass spectrometric techniques / Angela Amoresano ... [et al.] -- On-line liquid chromatography electron capture dissociation for the characterization of phosphorylation sites in proteins / Steve M.M. Sweet and Helen J. Cooper -- Quantification of protein phosphorylation by [mu]LC-ICP-MS / Ralf Krüger, Nico Zinn, and Wolf D. Lehmann -- Reverse-phase diagonal chromatography for phosphoproteome research / Kris Gevaert and Joël Vandekerckhove -- Chemical tagging strategies for mass spectrometry-based phospho-proteomics / Alexander Leitner and Wolfgang Lindner -- Antibody array platform to monitor protein tyrosine phosphorylation in mammalian cells / Alicia S. Chung and Y. Eugene Chin -- Protein tyrosine kinase characterization based on fully automated synthesis of (phospho)peptide arrays in microplates / W. Carl Saxinger -- Kinome profiling using peptide arrays in eukaryotic cells / Kaushal Parikh, Maikel P. Peppelenbosch, and Tita Ritsema -- ProMoST : a tool for calculating the pI and molecular mass of phosphorylated and modified proteins on two-dimensional gels / Brian D. Halligan -- Kinase-specific preiction of protein phosphorylation sites / Martin L. Miller and Nikolaj Blom -- Reconstructing regulatory kinase pathways from phosphopeptide data : a bioinformatics approach / Lawrence G. Puente, Robin E.C. Lee, and Lynn A. Megeney.
  • Purification of PDE6 isozymes from mammalian retina / Dana C. Pentia ... [et al.] -- Cyclic guanosine 5'-monophosphate binding to the regulatory GAF domains of photoreceptor phosphodiesterase / Rick H. Cote -- Renaturation of the catalytic domain of PDE4A expressed in escherichia coli as inclusion bodies / Wito Richter, Thomas Hermsdorf, and Dietrich Dettmer -- Determining the subunit structure of phosphodiesterases using gel filtration and sucrose density gradient centrifugation / Wito Richter -- Crystallization of cyclic nucleotide phosphodiesterases / Hengming Ke, Qing Huai, and Robert X. Xu -- Generation of PDE4 knockout mice by gene targeting / S.-L. Catherine Jin, Anne M. Latour, and Marco Conti -- Immunoprecipitating PDE2 phosphorylated and inactivated by an associated protein kinase / J. Kelley Bentley -- Investigation of extracellular signal-regulated kinase 2 mitogen-actived protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases / Elaine V. Hills, Miles D. Houslay, and George S. Baillie -- Radiolabeled ligand binding to the catalytic or allosteric sites of PDE5 and PDE11 / James L. Weeks ... [et al.] -- Analysis of dimerization determinants of the PDE6 catalytic subunits / Khakim G. Muradov, Kimberley K. Boyd, and Nikolai O. Artemyev -- Interaction between catalytic and inhibitory subunits of PDE6 / Nikolai O. Artemyev -- Purification, reconstitution on lipid vesciles and assays of PDE6 and its activator G protein, transducin -- Theodore G. Wensel, Feng He, and Justine A. Malinski. Study of cyclic adenosine monophosphate microdomains in cells / Marco Mongillo ... [et al.] -- High-resolution measurements of cyclic adenosine monophosphate signals in 3D microdomains / Jeffrey W. Karpen and Thomas C. Rich -- Cygnets : in vivo characterization of novel cGMP indicators and in vivo imaging of intracellular cGMP / Akira Honda ... [et al.] -- High-throughput screening of phosphodiesterase activity in living cells / Thomas C. Rich and Jeffrey W. Karpen -- Assessment of phosphodiesterase isozyme contribution in cell and tissue extracts / Thèrése Keravis, Rima Thaseldar-Roumié, and Claire Lugnier -- Localization of the cyclic guanosine 3', 5'-monophosphate-hydrolysing phosphodiesterase type 9 in rat brain by nonradioactive in situ hybridization / Wilma C.G. Van Staveren and Marjanne Markerink-Van Ittersum -- Determination of Ca2+/calmodulin-stimulated phosphodiesterase activity in intact cells / Chen Yan -- Adenovirus-mediated overexpression of murine cyclic nucleotide phosphodiesterase 3B / Faiyaz Ahmad ... [et al.] -- Identification of promoter elements in the 5'-flanking region of the murine cyclic nucleotide phosphodiesterase 3B gene / Hanguan Liu ... [et al.] --
  • v. 2, 2011 Springer
    Vol. 1 / (ix, 306 p.) -- v. 2. / (x, 301 p.).
  • Phosphoinositides (PIs) are minor components of cellular membranes that play critical regulatory roles in several intracellular functions. This book describes the main enzymes regulating the turnover of each of the seven PIs in mammalian cells, some of their intracellular functions and some evidence of their involvement in human diseases. Due to the complex inter-relation between the distinct PIs and the plethora of functions that they can regulate inside a cell, this book is not meant to be a comprehensive coverage of all aspects of PIs signalling but rather an overview on the current state of the field and where it could go from here. Phosphoinositide and inositol phosphates interact with and modulate the recruitment and activation of key regulatory proteins and in doing so control diverse functions including cell growth and proliferation, apoptosis, cytoskeletal dynamics, insulin action, vesicle trafficking and nuclear function. Initially, inositide signaling was limited to the PLC pathway; however, it is now clear that all the seven phosphoinositides and more than 30 different inositol phosphates likely have specific signaling functions. Moreover there is a growing list of proteins that are regulated by inositol signaling. This has raised the question as to how inositol signaling can control diverse processes and yet maintain signaling specificity. Controlling the levels of inositol signaling molecules and their subcellular compartmentalisation is likely to be critical. This meeting will bring together scientists from different backgrounds to discuss how understanding inositol signaling may be used to target complex human diseases that manifest themselves when inositol signaling is deregulated.
  • The Phosphatidylinositol 4-Kinases: Don't Call it a Comeback / Shane Minogue and Mark G. Waugh -- PIP Kinases from the Cell Membrane to the Nucleus / Mark Schramp, Andrew Hedman, Weimin Li, Xiaojun Tan and Richard Anderson -- The Phospholipase C Isozymes and Their Regulation / Aurelie Gresset, John Sondek and T. Kendall Harden -- Phosphoinositide 3-Kinases-A Historical Perspective / Alex Toker -- PI3Ks-Drug Targets in Inflammation and Cancer / Matthias Wymann -- Phosphoinositide 3-Kinases in Health and Disease / Alessandra Ghigo, Fulvio Morello, Alessia Perino and Emilio Hirsch -- Phosphoinositide Phosphatases: Just as Important as the Kinases / Jennifer M. Dyson, Clare G. Fedele, Elizabeth M. Davies, Jelena Becanovic and Christina A. Mitchell -- The PTEN and Myotubularin Phosphoinositide 3-Phosphatases: Linking Lipid Signalling to Human Disease / Nicholas R. Leslie, Elizabeth M. Davies, David A. Sheffield, Priyanka Tibarewal and Clare G. Fedele, et al.
  • Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol.
  • Phospholipases
  • Phospholipases generate lipid signaling molecules through their hydrolytic action on phospholipids and are known to regulate function of a variety of cells under normal and diseased conditions. While several physiological, biochemical and molecular techniques have identified key players involved in different disease processes, phospholipases have also emerged as critical players in the pathogenesis of a number of different diseases including cancer and heart disease. In addition, phospholipases are also implicated in such conditions as brain disorder/injury, kidney and immune cell dysfunction. Phospholipases in Health and Disease is a compilation of review articles dedicated to the study of the field with respect to biochemical and molecular mechanisms of normal and abnormal cell function. The wide range of area covered here is of interest to basic research scientists, clinicians and graduate students, who are engaged in studying pathophysiological basis of a variety of diseases. Furthermore, this book highlights the potential of the different phospholipases as therapeutic targets as well as part of prevention strategies. Twenty three articles in this book are organized in four sections that are designed to emphasize the most characterized forms of the phospholipases in mammalian cells. The first section discusses general aspect of phospholipases. Section two covers the role and function of phospholipase A in different pathophysiological conditions. The third section is focussed on phospholipase C which is believed to play a central role in transmembrane signaling. The final section covers phospholipase D which is present in a variety of different cells. The book illustrates that the activation of phospholipases is of fundamental importance in signal transduction affecting cell function. Overall, this book discusses the diverse mechanisms of phospholipase mediated signal transduction in different pathophysiological conditions and raises the possibility of specific forms of phospholipases serving as novel targets for drug development.
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    v. 1. Metabolism.
  • O2-Sensitive Probes Based on Phosphorescent Metalloporphyrins / Ruslan I. Dmitriev and Dmitri B. Papkovsky -- O2 Analysis on a Fluorescence Spectrometer or Plate Reader / Alexander V. Zhdanov, James Hynes, Ruslan I. Dmitriev and Dmitri B. Papkovsky -- O2 Imaging in Biological Specimens / Andreas Fercher, Alexander V. Zhdanov and Dmitri B. Papkovsky.
  • This title in the PROCEDURES IN COSMETIC DERMATOLOGY SERIES presents up-to-the-minute, practical guidance on the hottest photodynamic therapy techniques shaping today's practice. Succinctly written and lavishly illustrated, it focuses on procedural how-to's and offer step-by-step advice on proper techniques, pitfalls, and tricks of the trade--so you can refine and hone your skills ... and expand your surgical repertoire. You'll find current, to-the-point guidance on the cosmetic use of PDT--edited by a pioneer in the field, Dr. Mitchel P. Goldman. Implement the newest procedures into your practice immediately and confidently--with the outstanding guidance you'll find in this volume of the PROCEDURES IN COSMETIC DERMATOLOGY SERIES. Get the best results when performing PDT for skin diseases, skin cancer and HPV, and skin rejuvenation, especially in aging and sun-damaged skin --all in one concise, accessible volume. Visualize techniques clearly with a wealth of color illustrations and photographs that depict cases as they appear in practice. Know the costs for each light source, and get recommendations from the experts on which light source is best for your practice. Ensure the safety of your clients with post-photodynamic therapy care information sheets for patients.
  • Part 1. Propagation of light -- ch. 1. Overview -- ch. 2. Review of optics -- ch. 3. Planar waveguides -- ch. 4. Cylindrical waveguides -- ch. 5. Losses in optical fibers -- ch. 6. Dispersion in optical fibers -- ch. 7. Fiber connections and diagnostics -- ch. 8. Photonic crystal optics -- ch. 9. Nonlinear optics -- Part 2. Generation and Detection of Light -- ch. 10. Review of semiconductor physics -- ch. 11. Light sources -- ch. 12. Light source to waveguide coupling efficiency -- ch. 13. Optical detectors -- ch. 14. Photodiode detectors -- Part 3. Laser light -- ch. 15. Lasers and coherent light -- ch. 16. Optical resonators -- ch. 17. Guassian beam optics -- ch. 18. Stimulated emission and optical gain -- ch. 19. Optical amplifiers -- ch. 20. Laser oscillation -- ch. 21. CW laser characteristics -- ch. 22. Pulsed lasers -- ch. 23. Survey of laser types -- Part 4. Light-based communications -- ch. 24. Optical communications -- Appendix A. Solid angle and the brightness theorem -- Appendix B. Fourier synthesis and the uncertainty relation.
  • Photoshop CS3 bible 2007
    ProQuest Safari
    2007 books24x7, SUNet ID login required.
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  • Ch. 1. Taxonomy of the genus Phyllanthus / Sheeja T. Tharakan -- ch. 2. Current pharmacopoeial status of Phyllanthus species : P. emblica, P. amarus, and P. fraternus / Raman Mohan Singh and Vivekanandan Kalaiselvan -- ch. 3. Cultivation, economics, and marketing of Phyllanthus species / B.R. Rajeswara Rao -- ch. 4. Phylogenetic analysis of Phyllanthus species / Srinivasu Tadikamalla -- ch. 5. Genetic resources of Phyllanthus in southern India : identification of geographic and genetic hot spots and its implication for conservation / G. Ravikanth [and others] -- ch. 6. Phytochemistry of the genus Phyllanthus / Lutfun Nahar, Satyajit D. Sarker, and Abbas Delazar -- ch. 7. Hyphenated techniques in the study of the genus Phyllanthus / Satyajit D. Sarker, Lutfun Nahar, and Abbas Delazar -- ch. 8. Anti-inflammatory activity of various species of Phyllanthus / K.B. Harikumar and Ramadasan Kuttan -- ch. 9. Hepatoprotective effects of plants in the family Phyllanthaceae / V.V. Asha -- ch. 10. Anticancer studies of Phyllanthus amarus / K.B. Harikumar and Ramadasan Kuttan -- ch. 11. Anticancer activity of Phyllanthus emblica / Jeena Joseph and Ramadasan Kuttan -- ch. 12. The In Vivo and In Vitro proapoptotic and antiangiogenic effects of Phyllanthus urinaria / Jong-Hwei S. Pang [and others] -- ch. 13. Phyllanthus and Hepatitis B, Hepatitis C, and HIV infections / S.P. Thyagarajan -- ch. 14. Antiviral activities of Phyllanthus orbicularis, an endemic Cuban species / Gloria del Barrio and Francisco Parra -- ch. 15. Diabetes and diabetic complications and Phyllanthus species / Geereddy Bhanuprakash Reddy and Palla Suryanarayana -- ch. 16. Chemoprotective, genotoxic, and antigenotoxic effects of Phyllanthus Sp / Rakesh K. Johri -- ch. 17. Antiaging effects of Phyllanthus species / Vasudevan Mani and Shanmugapriya Thulasimani -- ch. 18. Toxicity studies of Phyllanthus species / K.N.S. Sirajudeen -- ch. 19. Clinical trials involving Phyllanthus species / Mulyarjo Dirjomuljono and Raymond R. Tjandrawinata -- ch. 20. Immunomodulatory activity of Brahma Rasayana, an herbal preparation containing Phyllanthus emblica as the main ingredient / Praveen K. Vayalil, Ramadasan Kuttan, and Girija Kuttan -- ch. 21. Triphala : an Ayurvedic drug formulation / Sandhya T. Das and K.P. Mishra -- ch. 22. Kalpaamruthaa : a successful drug against various ailments / P. Sachdanandam and P. Shanthi.
  • Phylogenomics 2008
    Springer Protocols
    From gene-scale to genome-scale phylogenetics : the data flood in, but the challenges remain / Antonis Rokas and Stylianos Chatzimanolis -- Phylogenomic analysis of chromosome sorting and painting / Roscoe Stanyon and Gary Stone -- FISH for mapping single copy genes / Terje Raudsepp and Bhanu P. Chowdhary -- Construction of radiation hybrid panels / John E. Page and William J. Murphy -- Survey sequencing and radiation hybrid mapping to construct comparative maps / Christophe Hitte ... [et al.] -- Construction of high-resolution comparative maps in mammals using BAC-end sequences / Denis M. Larkin and Harris A. Lewin -- Amniote phylogenomics : testing evolutionary hypotheses with BAC library scanning and targeted clone analysis of large-scale sequences from reptiles / Andrew M. Shedlock, Daniel E. Janes, and Scott V. Edwards -- Comparative physical mapping : universal overgo hybridization probe design and BAC library hybridization / James W. Thomas -- Phylogenomic resources at the UCSC Genome Browser / Kate Rosenbloom ... [et al.] -- Computational tools for the analysis of rearrangements in mammalian genomes / Glenn Tesler and Guillaume Bourque -- Computational reconstruction of ancestral DNA sequences / Mathieu Blanchette ... [et al.] -- Sequencing and phylogenomic analysis of whole mitochondrial genomes of animals / Rafael Zardoya and Mónica Suárez -- Retroposons : genetic footrpints on the evolutionary paths of life / Hidenori Nishihara and Norihiro Okada -- LINE-1 elements : analysis by FISH and nucleotide sequences / Paul D. Waters ... [et al.] -- Identification of cryptic sex chromosomes and isolation of X- and Y-borne genes / Paul D. Waters ... [et al.]
  • Vascular Deficiency -- Disuse -- Infection -- Tumor -- Metabolic -- Neural -- Cold Injury (Frostbite) -- Heat Injury (Burns) -- Electric Injuries -- Compression -- Distraction -- Stress -- Irradiation -- Light Waves -- Sound Waves -- Shock Waves -- Atmospheric Pressure -- Oxygen -- Developmental -- Surgical -- Unknown.
  • This book explores in depth the relation between physical activity and cancer control, including primary prevention, coping with treatments, recovery after treatments, long-term survivorship, secondary prevention, and survival. The first part of the book presents the most recent research on the impact of physical activity in preventing a range of cancers. In the second part, the association between physical activity and cancer survivorship is addressed. The effects of physical activity on supportive care endpoints (e.g., quality of life, fatigue, physical functioning) and disease endpoints (e.g., biomarkers, recurrence, survival) are carefully analyzed. In addition, the determinants of physical activity in cancer survivors (e.g., medical, social cognitive, environmental) are discussed, and behavior change strategies for increasing physical activity in cancer survivors (e.g., counseling, print materials) are appraised. The final part of the book is devoted to further special topics, including the relation of physical activity to pediatric cancer survivorship and to palliative cancer care.
  • Promotes value of lifelong moderate exercise.
  • Ch. 1. History of physical activity contributions to public health / Amanda E. Paluch ... [et al.] -- Ch. 2. Physiological adaptations to moderate-intensity aerobic exercise / Arthur S. Leon and Scott Brown -- Ch. 3. The unique influence of sedentary behavior on health / Genevieve N. Healy -- Ch. 4. Physical activity in chronic disease prevention / Jared P. Reis and Bethany Barone Gibbs -- Ch. 5. Physical activity and injury prevention / Kenneth E. Powell -- Ch. 6. Physical activity in treatment of chronic conditions / J. Larry Durstine, Keith Burns, and Ryan Cheek -- Ch. 7. Physical activity in growth and development / Fátima Baptista and Kathleen F. Janz -- Ch. 8. Physical activity and healthy adulthood / Kelley K. Pettee Gabriel and Jennifer L. Gay -- Ch. 9. Physical activity and healthy aging / David M. Buchner -- Ch. 10. Physical activity and obesity / Catrine Tudor-Locke -- Ch. 11. Physical activity measurement / Stephen D. Herrmann -- Ch. 12. National guidelines for physical activity / Richard P. Troiano and David M. Buchner -- Ch. 13. Surveillance of physical activity / Janet E. Fulton and Susan A. Carlson -- Ch. 14. Physical activity promotion in underserved communities / Deborah Parra-Medina and Zenong Yin -- Ch. 15. Built environmental supports for walking / Paula Hooper ... [et al.] -- Ch. 16. Physical activity promotion in worksites / Joan Dorn and Cassandra Hoebbel -- Ch. 17. Promotion of physical activity in schools / Dianne Stanton Ward and Christopher Ford -- Ch. 18. Policy for physical activity promotion / Kelly R. Evenson and Semra A. Aytur
  • Epidemiology of overweight/obesity and cancer risk -- Epidemiology of physical activity and cancer risk -- Energetics and cancer: exploring a road less traveled -- Calorie restriction, exercise, and colon cancer prevention: a mechanistic perspective -- Mechanisms linking obesity to cancer risk -- Mechanisms underlying the effects of physical activity on cancer -- Physical activity, weight control, and cancer prognosis.
  • Preface -- Part I: Current Status of Physical Activity and Sedentary Behavior Research -- Physical Activity Levels and Physical Activity Recommendations in Japan -- Population Strategy for Physical Activity Promotion in the Community -- Promotion of Strength Training -- Does Newspaper Coverage Promote Cancer Prevention? -- Health Impact of Light -- Evaluation of Physical Activity and Sedentary Behavior -- Sedentary Behaviour -- Prevalence, Trends, and Correlates of Sedentary Behavior -- Part II: Effects of Physical Activity, Exercise, and Fitness on the Human Organism -- Responses of the Autonomic Nervous and Endocrine Systems to Exercise -- Exercise Modes and Vascular Functions -- Exercise, Appetite Control, and Body Weight Regulation -- Exercise and Food Intake -- Role of Physical Exercise on Postprandial Blood Glucose Responses to Low-Carbohydrate/High-Fat Diet Intake -- Posttranslational Modification of Proteins -- Relationship of Cardiorespiratory Fitness and Obesity Genes to Metabolic Syndrome in Adult Japanese Men -- Mechanisms Underlying the Suppression of Inflammatory Responses in Peritoneal Macrophages of Middle-aged Mice -- Effects of b2-Agonist Administration on Bacterial Phagocytosis by Splenic Macrophages in Mice -- Functional Roles of b2-Adrenergic Receptors in Skeletal Muscle Hypertrophy and Atrophy -- Part III: Physical Activity, Exercise, Nutrition, Aging, and Health -- The Role of Exercise and Nutrition in Lifestyle-related Disease -- Vasopressin V1a receptor gene and voluntary exercise in humans and mice -- The Role of Physical Activity in the Prevention of Atherosclerosis -- Association Between Exercise and Diet on Maintaining Bone Health in Postmenopausal Women and Female Athletes -- Pain Management Among Elderly People with Knee Pain -- Effective Exercise Programs Among Frail Elderly People -- Rowing -- Influence of Aging on Postural Control in Terms of Sensory Movements.
  • pt. 1. Principles of biophysical inquiry -- pt. 2. Foundations -- pt. 3. Building a model of biomolecular structure -- pt. 4. Function and action biological state space -- pt. 5. Methods for the measuring structure and function -- pt. 6. Physical constants.
  • Chapter 1. Heat, Work, and Energy (pages 1-21) -- Chapter 2. Entropy and Gibbs Energy (pages 23-42) -- Chapter 3. Applications of Thermodynamics to Biological Systems (pages 43-76) -- Chapter 4. Thermodynamics Revisited (pages 77-94) -- Chapter 5. Principles of Chemical Kinetics (pages 95-120) -- Chapter 6. Applications of Kinetics to Biological Systems (pages 121-152) -- Chapter 7. Fundamentals of Quantum Mechanics (pages 153-176) -- Chapter 8. Electronic Structure of Atoms and Molecules (pages 177-202) -- Chapter 9. X-ray Crystallography (pages 203-224) -- Chapter 10. Electronic Spectra (pages 225-252) -- Chapter 11. Circular Dichroism, Optical Rotary Dispersion, and Fluorescence Polarization (pages 253-276) -- Chapter 12. Vibrations in Macromolecules (pages 277-288) -- Chapter 13. Principles of Nuclear Magnetic Resonance and Electron Spin Resonance (pages 289-314) -- Chapter 14. Applications of Magnetic Resonance to Biology (pages 315-330) -- Chapter 15. Fundamentals of Statistical Mechanics (pages 331-356) -- Chapter 16. Molecular Simulations (pages 357-382) -- Chapter 17. Ligand Binding to Macromolecules (pages 383-414) -- Chapter 18. Hydrodynamics of Macromolecules (pages 415-440) -- Chapter 19. Mass Spectrometry (pages 441-456).
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    Approachable, yet thorough, this book presents physical chemistry in conceptual terms with a minimum of mathematics. Providing the basic knowledge and tools that every biologist should have to understand the quantitative interpretation of biological phenomena, it covers: Fundamentals of thermodynamics and chemical kinetics ; Fundamentals of spectroscopy and structure determination ; Ligand binding to macromolecules, hydrodynamics, and mass spectrometry. All techniques and concepts are clearly illustrated with relevant applications and examples from the biological sciences. Problems at the end of each chapter reinforce the principles.
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    General inspection and vital signs -- Dermatology-- Head, ears, eyes nose, and throat -- Pulmonary/critical care -- Cardiovascular System -- Gastrointestinal system -- Renal and genitourinary system -- Endocrinology -- Hematology and oncology -- Rheumatology -- Musculoskeletal system -- Neurology -- Geriatrics -- Infectious diseases -- Obstetrics and gynecology -- Pediatrics and neonatology -- Bonus chapter: The ten toughest physical diagnosis question ever written -- High yield facts.
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  • Chest inspection, palpation, and percussion / Salvatore Mangione -- Lung auscultation / Salvatore Mangione -- The abdomen / Salvatore Mangione -- Male genitalia, hernias, and rectal exam / Salvatore Mangione -- Pelvic examination / Salvatore Mangione -- Lymph nodes / Salvatore Mangione -- Neurologic examination / Enrica Arnaudo and Michael D. Kim -- Bedside diagnosis of coma / Salvatore Mangione -- The musculoskeletal system / Salvatore Mangione -- The extremities / Salvatore Mangione. Top 100 secrets -- General appearance, facies, and body habitus / Salvatore Mangione -- Vital signs / Salvatore Mangione -- The skin / Salvatore Mangione -- Eye examination / Salvatore Mangione -- The ear / Salvatore Mangione -- Nose and mouth / Salvatore Mangione -- Neck examination / Salvatore Mangione -- Thyroid gland / Salvatore Mangione -- Breast examination / Salvatore Mangione -- Cardiovascular physical exam / Salvatore Mangione -- Heart sounds and extra-sounds / Salvatore Mangione -- Cardiac auscultation murmurs / Salvatore Mangione --
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    Part I: An introduction to aging -- Part II: Physical changes in structure, capacity, and endurance -- Part III: Motor coordination, motor control, and skill -- Part IV: Physical-psychosocial relationships -- Part V: Physical performance and achievement.
  • About this Book -- Range of Motion -- Strenght Testing -- Strength Testing -- Rotator Cuff Disorders -- Disorders of the Long Head of the Biceps Tendon -- Glenohumeral Instability -- The Acromioclavicular Joint -- The Sternoclavicular Joint -- Scapular Dyskinesis -- Neurovascular Disorders.
  • Physical examination of the spine 2005
    Thieme eNeurosurgery
    The fundamentals -- Physical examination of the cervical spine -- Physical examination of the thoracic spine -- Physical examination of the lumbosacral spine.
  • "This completely updated top-seller in physical medicine and rehabilitation continues the tradition of the highly popular Secrets Series. From anatomy and physiology of the nervous and musculoskeletal system to medical complications in rehabilitation to work and rehabilitationthis book presents all the key elements you need for clinical use, rounds, and board preparation."--Publisher's website.
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    The physiatric history and physical examination -- Examination of the pediatric patient -- Adult neurogenic communication disorders -- Psychological assessment and intervention in rehabilitation -- Gait analysis: technology and clinical applications -- Impairment rating and disability determination -- Neurologic and musculoskeletal imaging studies -- Quality and outcome measures for medical rehabilitation -- Electrodiagnostic medicine I: fundamental principles -- Electrodiagnostic medicine II: clinical evaluation and findings -- Electrodiagnostic medicine III: case studies -- Rehabilitation and prosthetic restoration in upper limb amputation -- Rehabilitation and prosthetic restoration in lower limb amputation -- Upper limb orthotic devices -- Lower limb orthotic devices -- Spinal orthoses -- Wheelchairs and seating systems -- Therapeutic exercise -- Manipulation, traction, and massage -- Physical agent modalities -- Electrical stimulation -- Integrative medicine in rehabilitation -- Computer assistive devices and environmental controls -- Peripheral joint and soft tissue injection techniques -- Spinal injection techniques -- Achieving functional independence -- Rehabilitation of patients with swallowing disorders -- Management of bladder dysfunction -- Neurogenic bowel: dysfunction and rehabilitation -- Spasticity management -- Sexuality dysfunction and disability -- Prevention and management of chronic wounds -- Cardiac rehabilitation -- Pulmonary rehabilitation -- Employment of persons with disabilities -- Rheumatic diseases -- Common neck problems -- Musculoskeletal disorders of the upper limb -- Musculoskeletal disorders of the lower limb -- Low back pain -- Osteoporosis -- Chronic pain -- Muscle pain syndromes -- Sports medicine -- Occupational rehabilitation -- Motor neuron diseases -- Rehabilitation of patients with neuropathies -- Myopathic disorders -- Traumatic brain injury -- Stroke syndromes -- Degenerative movement disorders of the central nervous system -- Multiple sclerosis -- Cerebral palsy -- Myelominingocele and other spinal dysraphisms -- Spinal cord injury -- Lower limb peripheral vascular disease -- Cancer rehabilitation -- Burn rehabilitation -- Geriatric rehabilitation -- Transplantation of organs: rehabilitation to maximize outcomes -- International physical medicine and rehabilitation.
  • 2012 ClinicalKey
    Section 1. Foundational concepts in rehabilitation -- section 2. Upper extremity -- section 3. Spine -- section 4. Lower extremity -- section 5. Restoration of athletic performance.
  • "Clinical evidence clearly demonstrates that physical therapeutic measures begun as soon as possible after a stroke, often within 24 to 48 hours, greatly increase everyday competence and quality of life. Physical Therapy for the Stroke Patient: Early Stage Rehabilitation covers all the issues that physical therapists must deal with in this critical period: assessment of patients' abilities; care during the acute phase; early mobilization; effects of medication; risk factors; ethical questions; and much more. It provides complete guidelines on how to examine and treat the patient, the dosage" of physical therapy required, and the key differences between early and late stage rehabilitation after stroke. Special Features Information-packed chapter on Optimizing Functional Motor Recovery after Stroke," written by J. Carr and R. Shepherd, pioneers in the field and the first to correlate motor learning and stroke recovery Case studies throughout the book offering direct, hands-on examples of evaluation and treatment methods Nearly 150 color photographs demonstrating step-by-step physical therapy techniques used in actual practice Hundreds of references to the literature that support the evidence-based approach presented in the book For all physical and occupational therapists who must answer the question, How much therapy will help my patient?", this book provides clear, well-informed answers. Not only will it increase your therapeutic skills and confidence, but it will also expand your knowledge of the medical issues and long-term outcomes for the post-stroke patients in your care"--Provided by publisher.
  • Guide to practice -- Mechanics of movement and evaluation -- Functional anatomy and mechanics -- Throwing injuries -- Examinations and evaluation of the shoulder -- Neurologic considerations -- Interrelationship of the spine, rib cage, and shoulder -- Neural tissue evaluation and treatment -- Sensory integration and neuromuscular control of the shoulder -- Evaluation and treatment of brachial plexus lesions -- Special considerations -- Impingement syndrome and impingement-related instability -- Shoulder instability -- Frozen shoulder -- Etiology and evaluation of rotator cuff pathologic conditions and rehabilitation -- Visceral referred pain to the shoulder -- Treatment approaches -- Manual therapy techniques -- Muscle length testing and electromyographic evidence for manual strength testing and exercises for the shoulder -- Myofascial trigger points of the shoulder -- Strength training concepts -- Surgical considerations -- Rotator cuff repairs -- Surgical approach to shoulder instabilities -- Total shoulder replacements.
  • pt. 1. Getting started as physician-scientist. -- Beginnings -- Is a physician-scientist career right for you? -- Training as a physician-scientist -- pt. 2. Launching your career as a physician-scientist. -- Getting a job -- Appointments, tenure, promotions, and sabbaticals -- Teaching -- Administration -- Research -- pt. 3. Building your career as a physician-scientist. -- Writing -- Publishing -- Grants -- Grantsmanship -- Peer review of grant applications -- Managing your team, time, and money -- Mentorship -- Lectures and presentations -- Relations with industry -- pt. 4. Parting words of advice : putting it all together. -- Balancing research, clinical activities, and family life -- Improving the physician-scientist pathway -- Concluding remarks.
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  • Goals for your investment returns -- The magnificence of compound interest -- Arrogance, ego, and greed -- The mark -- It's not much, I can afford to lose it -- Define specific goals -- Thrift -- Invest in what you know -- Make your own investment decisions -- Documents required for financial security -- The importance of relationships -- Paying daily bills -- Your home -- Funding your children's education -- Insurance -- Funding retirement -- Who can you trust -- The malevolence of debt -- The perniciousness of fees -- Tips : real opportunities or useless information -- Areas where caution is essential or that should be completely avoided -- Yes or no -- Dealing with bankers -- Asset allocation and diversification -- How to identify real investment opportunities -- When to buy -- When to sell -- Stocks, bonds, and mutual funds -- Real estate other than your home -- Other types of investments -- Obtaining investment information -- Investment strategies of the pros -- Some miscellaneous tidbits of advice.
  • Introductory Chapters -- Amino acids -- Organic acids -- Vitamins and neurotransmitter -- Energy metabolism -- Organelles -- Selected disorder -- Biochemical phenotypes of questionable clinical significance -- Profiles.
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    " ... explains and describes the applications of philosophy, logic and critical thinking in particular, in medicine."--Back cover.
  • Physicians at war: the dual-loyalties challenge / Fritz Allhoff -- Dual-loyalty and human rights in health professional practice: proposed guidelines and institutional mechanisms / International Dual-Loyalty Working Group -- Guidelines to prevent the malevolent use of physicians in war / Michael E. Frisina -- Dual disloyalties: law and medical ethics at Guantanamo Bay / Jonathan H. Marks -- Toward a framework for military health ethics / Gervase Pearce, Peter Saul -- Physician involvement in hostile interrogations / Fritz Allhoff -- Indecent medicine revisited: considering physician involvement in torture / Richard Matthews -- Torture and the regulation of the health care professions / John Lunstroth -- Is medicine a pacifist vocation or should doctors help build bombs? / Michael L. Gross -- The case against doctor involvement in weapons design and development / Vivienne Nathanson -- Armed conflict and value conflict: case studies in biological weapons / Michael J. Selgelid -- Ethics and the dual-use dilemma in the life sciences / Seumas Miller, Michael J. Selgelid -- Triage priorities and military physicians / Marcus P. Adams -- Medical neutrality and political activism: physicians' roles in conflict situations / Justin M. List.
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    Principles of cancer chemotherapy -- Chemotherapeutic and biologic drugs -- Guidelines for chemotherapy and dosing modifications -- Common chemotherapy regimens in clinical practice -- Antiemetic agents for the treatment of chemotherapy-induced nausea and vomiting.
  • Increasingly, physicians are leveraging their medical training and expertise to pursue careers in non-traditional arenas. Their goals are diverse: · Explore consulting as a way to improve patient care· Lay the foundation for a career in academic medicine· Provide leadership in healthcare · Strengthen ties between a clinic and the community· Broaden ones experience as a medical student · As a journalist or writer, open a window onto medicine for non-experts Some physicians will pursue another degree, while others may not, in anticipation of moving into public service, business, education, law, or organized medicine. Their common ground is the desire to enhance their professional fulfillment.Drs. Urman and Ehrenfelds book features individual chapters on the wide array of non-traditional careers for physicians, each one written by an outstanding leader in medicine who him- or herself has successfully forged a unique career path. A final chapter brings together fascinating brief profiles case studies of physicians who have distinguished themselves professionally outside of traditional settings. Suitable for readers at any point in their medical career practitioners, fellows, residents, and medical students who want to explore possibilities beyond traditional medical practice, the book also sets out common-sense advice on topics such as work-life balance, mentorship, and the relationship between personality and job satisfaction.
  • Structure of Matter -- Radioactive Decay -- Kinetics of Radioactive Decay -- Statistics of Radiation Counting -- Production of Radionuclides -- Interaction of Radiation with Matter -- Gas-Filled Detectors -- Scintillation and Semiconductor Detectors -- Gamma Cameras -- Performance Parameters of Gamma Cameras -- Digital Computers in Nuclear Medicine -- Single Photon Emission Computed Tomography -- Positron Emission Tomography -- Internal Radiation Dosimetry -- Radiation Biology -- Radiation Regulations and Protection.
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    "In Physics in Mind, eminent biophysicist Werner R. Loewenstein seeks answers to these perplexing questions in the mechanisms of physics. Bringing information theory--the idea that all information can be quantified and encoded in bits--to bear on recent advances in the neurosciences, Loewenstein reveals inside the brain a web of immense computational power capable of rendering a coherent representation of the world outside. He guides us on an exhilarating journey along the sensory data stream of the brain--the stream that nurses our cognitions--and we see how the vast amounts of information coming in from the world outside get processed by the web, how its neurons gradually extract meaning from this hodgepodge, and how they arrive at a coherent picture of the world." -- [Publisher-supplied data]
  • 2012 ClinicalKey
    What is nuclear medicine? -- Basic atomic and nuclear physics -- Modes of radioactive decay -- Decay of radioactivity -- Radionuclide and radiopharmaceutical production -- Interaction of radiation with matter -- Radiation detectors -- Electronic instrumentation for radiation detection systems -- Nuclear counting statistics -- Pulse-height spectrometry -- Problems in radiation detection and measurement -- Counting systems -- The gamma camera : basic principles -- The gamma camera : performance characteristics -- Image quality in nuclear medicine -- Tomographic reconstruction in nuclear medicine -- Single photon emission computed tomography -- Positron emission tomography -- Hybrid imaging : SPECT/CT and PET/CT -- Digital image processing in nuclear medicine -- Tracer kinetic modeling -- Internal radiation dosimetry -- Radiation safety and health physics.
  • "The text is organized into concise chapters, each discussing an important point relevant to clinical MR and illustrated with images from routine patient exams. The topics covered encompass the breadth of the field, from imaging basics and pulse sequences to advanced topics including contrast-enhanced MR angiography, spectroscopy, perfusion, and advanced parallel imaging techniques. Discussion of the latest hardware and software innovations--for example, MR-PET, interventional MR, compressed sensing, and multishot EPI--is included because these topics are critical to current and future advances. Included in the third edition are a large number of new topics, keeping the text up-to-date in this increasingly complex field. The text has also been revised to include additional relevant clinical images, to improve the clarity of descriptions, and to increase the depth of content"--Provided by publisher.
  • Terminology, the standard human, and scaling -- Statics of the body -- Motion -- Mechanical properties of the body -- Muscles -- Metabolism: energy, heat, work, and power -- Fluid pressure, fluid flow in the body, and motion in fluids -- Cardiovascular system -- Lungs and breathing -- Sound, speech, and hearing -- Light, eyes, and vision -- Electrical and magnetic properties -- Feedback and control -- Appendix A. Symbols and units -- Appendix B. Locator of major anatomical and anthropometric information -- Appendix C. Differential equations -- Appendix D. Similar model systems -- Appendix E. Biophysics of the human body.
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    Bd. 1. Die Behandlung innerer Krankheiten durch Klima, spectrale Strahlung und Freiluft, Meteorotherapie.
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    Pt 1 Efficiency of young men under temperate conditions -- Pt. II, v. 1. Efficiency of young men under conditions of moderate cold -- Pt. III. Efficiency of young men under conditions of moist heat -- Pt. III, v.2. Efficiency of young men under conditions of moist heat appendices of methods and original data -- Pt. IV. Integrative study of the all-purpose survival ration for temperate, cold and hot weather.
  • "Physiology and medicine are interrelated disciplines, and this is perhaps nowhere more apparent than in the field of mineral metabolism. This book presents information on the physiological principles regulating the response of mineral homeostasis on genetic, molecular, environmental, and nutritional factors. Chapters cover calcium and vitamin D nutrition, intestinal calcium absorption, plasma calcium homeostasis, renal handling of calcium, calcium sensing receptors, plasma phosphate homeostasis, endocrine actions of vitamin D, parathyroid hormone, calcitonin, and the calcification process"-- Provided by publisher.
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    v. 1. Mammalian populations, by J. B. Calhoun, J. J. Christian.--v. 2. Mammalian reactions to stressful environments.
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    1. Bd. Die Stoffe -- 2. Bd. Der Stoffwechsel.
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  • Recent Developments in the Molecular Taxonomy of Fungi / Roland W.S. Weber -- Sordaria macrospora, a Model System for Fungal Development / Ulrich Kück, Stefanie Pöggeler, Minou Nowrousian, Nicole Nolting and Ines Engh -- Inteins - Selfish Elements in Fungal Genomes / Skander Elleuche and Stefanie Pöggeler -- Apoptosis in Fungal Development and Ageing / Diana Brust, Andrea Hamann and Heinz D. Osiewacz -- Communication of Fungi on Individual, Species, Kingdom, and Above Kingdom Levels / Ursula Kües and Mónica Navarro-González -- Yeast Killer Toxins: Fundamentals and Applications / Friedhelm Meinhardt and Roland Klassen -- Evolutionary and Ecological Interactions of Mould and Insects / Marko Rohlfs, Monika Trienens, Ulrike Fohgrub and Frank Kempken -- Endophytic Fungi, Occurrence and Metabolites / Daniela Weber -- Fungal Origin of Ergoline Alkaloids Present in Dicotyledonous Plants (Convolvulaceae) / Eckhard Leistner and Ulrike Steiner -- Secondary Metabolites of Basidiomycetes / Anja Schüffler and Timm Anke -- Identification of Fungicide Targets in Pathogenic Fungi / Andrew J. Foster and Eckhard Thines -- Helminth Electron Transport Inhibitors Produced by Fungi / Rokuro Masuma, Kazuro Shiomi and Satoshi Ōmura -- Cyclic Peptides and Depsipeptides from Fungi / Heidrun Anke and Luis Antelo -- Fungal Genome Mining and Activation of Silent Gene Clusters / Axel A. Brakhage, Sebastian Bergmann, Julia Schuemann, Kirstin Scherlach and Volker Schroeckh, et al. -- Non-Ribosomal Peptide Synthetases of Fungi / Katrin Eisfeld -- Biosynthesis of Fungal Polyketides / Julia Schuemann and Christian Hertweck -- Physiological and Molecular Aspects of Ochratoxin A Biosynthesis / Rolf Geisen and Markus Schmidt-Heydt -- Genetic and Metabolic Engineering in Filamentous Fungi / Jochen Schmid, Ulf Stahl and Vera Meyer.
  • Written by internationally recognized leaders in hyperbaric oxygen therapy (HBOT) research and practice, this exciting new book provides evidence-based, practical, useful information for anyone involved in HBOT. It outlines the physiologic principles that constitute the basis for understanding the clinical implications for treatment and describes recent advances and current research, along with new approaches to therapy. This book is an essential tool for anyone who cares for patients with difficult-to-heal wounds, wounds from radiation therapy, carbon monoxide poisoning, and more. Provides comprehensive coverage of pathophysiology and clinically relevant information so you can master the specialty. Covers the relevance of HBOT in caring for diverse populations including critical care patients, infants and pediatric patients, and divers. Features a section on the technical aspects of HBOT to provide insight into the technology and physics regarding HBO chambers. Presents evidence to support the effectiveness of HBOT as well as the possible side effects. Describes situations where HBOT would be effective through indication-specific chapters on chronic wounds, radiation and crush injuries, decompression sickness, and more.
  • Part I. Overview of Chloride Transporters and Channels -- Part II. Current Methods for Studying Chloride Regulation -- Part III. From Cloning to Structure, Function and Regulation of Chloride Transporters and Channels -- Part IV. Cation-Chloride Cotransporters in Neural Function and Dysfunction -- Part V. Cation-Chloride Cotransport in Choroid Plexus and Blood-Brain Barrier.
  • The scientific advances in the physiology and pathophysiology of adipose tissue over the last two decades have been considerable. Today, the cellular and molecular mechanisms of adipogenesis are well known. In addition, adipose tissue is now recognized as a real endocrine organ that produces hormones such as the leptin acting to regulate food intake and energy balance in the central nervous system, a finding that has completely revolutionized the paradigm of energy homeostasis. Other adipokines have now been described and these molecules are taking on increasing importance in physiology and pathophysiology. Moreover, numerous works have shown that in obesity, but also in cases of lipodystophy, adipose tissue was the site of a local low-grade inflammation that involves immune cells such as macrophages and certain populations of lymphocytes. This new information is an important step in the pathophysiology of both obesity and related metabolic and cardiovascular complications. Finally, it is a unique and original work focusing on adipose tissue, covering biology and pathology by investigating aspects of molecular and cellular biology, general, metabolic, genetic and genomic biochemistry.
  • Measuring endogenous electric fields / Richard Nuccitelli -- Investigation systems to study the biological effects of weak physiological electric fields / Francis X. Hart -- Endogenous bioelectric signals as morphogenetic controls of development, regeneration, and neoplasm / Michael Levin -- Stem cell physiological responses to noninvasive electrical stimulation / Igor Titushkin ... [et al.] -- Electrical signals control corneal epithelial cell physiology and wound repair / Colin D. McCaig -- Physiological electric fields can direct keratinocyte migration and promote healing in chronic wounds / Christine E. Pullar -- Electrical control of angiogenesis / Entong Wang ... [et al.] -- Inflammatory cell electrotaxis / Francis Lin and Christine E. Pullar -- Effects of DC electric fields on migration of cells of the musculoskeletal system / Najmuddin J. Gunja, Clark T. Hung, and J. Chlöe Bulinski -- Neuronal growth cone guidance by physiological DC electric fields / Ann M. Rajnicek -- Can applied voltages be used to produce spinal cord regeneration and recovery in humans? / Richard Ben Borgens -- Bioelectricty of cancer : voltage-gated ion channels and direct-current electric fields / Mustafa B. A. Djamgoz.
  • Maternal Exercise Throughout Gestation and Fetal Development -- Effects of Maternal Exercise on Labor and Delivery -- Fetal and Postnatal Growth and Development -- Effect on Postnatal Health and Beyond -- What are the Barriers to and What is OK for an Exercise Study -- Conclusions.
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    v. 1. Optics -- v. 2. Vision.
  • 2012 ClinicalKey
    The gastrointestinal system is responsible for the breakdown and absorption of various foods and liquids needed to sustain life. Other diseases and disorders treated by clinicians in this area include: food allergies, constipation, chronic liver disease and cirrhosis, gallstones, gastritis, GERD, hemorrhoids, IBS, lactose intolerance, pancreatic, appendicitis, celiac disease, Crohn's disease, peptic ulcer, stomach ulcer, viral hepatitis, colorectal cancer and liver transplants. Physiology of the Gastrointestinal Tract, 5/e covers the study of the mechanical, physical, and biochemical functions of the GI Tract while linking the clinical disease or disorder, bridging the gap between clinical and laboratory medicine. The new edition is a highly referenced and useful resource for gastroenterologists, physiologists, internists, professional researchers, and instructors teaching courses for clinical and research students. Discusses the multiple processes governing gastrointestinal functionEach section edited by preeminent scientist in the fieldUpdated, four-color illustrations.
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    High-Yield Facts -- General Principles: Cellular Physiology -- General Principles: Multisystem Processes -- Physiology of the Hematopoietic and Lymphoreticular Systems -- Neurophysiology -- Musculoskeletal Physiology -- Respiratory Physiology -- Cardiovascular Physiology -- Gastrointestinal Physiology -- Renal and Urinary Physiology -- Reproductive Physiology -- Endocrine Physiology.
  • Clear, consistent, and user-friendly, the updated edition of Physiology, by renowned physiology instructor Dr. Linda Costanzo, offers a comprehensive overview of core physiologic concepts at the organ system and cellular levels. It presents information in a short, simple, and focused manner, making it an ideal combination textbook and review guide for the USMLE Step 1. You'll grasp all the essential and relevant physiology knowledge you need for absolute success in school and on your exams! Build a strong understanding of the underlying principles of cellular physiology, the autonomic nervous system, and neurophysiology, as well as the cardiovascular, respiratory, renal, acid-base, gastrointestinal, endocrine, and reproductive organ systems.\Grasp physiology principles with absolute clarity through step-by-step explanations, easy-to-follow diagrams, and a full-color design, in addition to physiology equations and sample problems integrated throughout the text. Effortlessly study important points and reinforce your understanding of physiology with the help of chapter summaries and review questions. Access the entire contents online at Student Consult, including an image bank, 8 animations, "Ask the Author" section, and FAQs.
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    "Preface The aim of this book is to show that many aspects of human physiology lend themselves to numerical analysis. Many ways of monitoring physiological function also rely on an understanding of physics and engineering to appreciate fully how they operate. The book arises out of an undergraduate course in medical biophysics and a postgraduate course in biomedical instrumentation the authors were involved in for many years. Although the emphasis is on numerical analysis only, a basic knowledge of mathematics is assumed and every effort is made to supplement mathematical formulae with qualitative explanations and illustrations to encourage an intuitive grasp on the processes involved. Most of the chapters have a range of numerical tutorial problems with, in most cases, worked solutions. These are based on examination questions at the middle and senior undergraduate level. For some of the material, the computational package MATLABʼ offers a convenient way to gain insight into some of the more advanced mathematical analysis of physiological or of clinical monitoring systems. Suitable MATLAB code is provided where this might aid understanding. I acknowledge the help of colleagues in the preparation of this book. Particular chapters have been authored as follows: Anthony Bartel, Per Line, Peter Cadusch, Joseph Ciorciari, David and Sheila Crewther, John Patterson , Mark Schier, Bruce Thompson. In addition, others have been associated with teaching the course over many years. These include: Peter Alabaster, David Liley, Ric Roberts and David Simpson"--Provided by publisher.
  • "Physiology--An Illustrated Review helps you master important physiologic facts and concepts and teaches you how to apply that knowledge successfully on course exams and in daily practice. This indispensable review book includes 200 spectacular, full-color illustrations depicting cardiologic, cellular, and renal function. It also includes all the regular series features, including 400 print and online review questions and explanatory answers"--Provided by publisher.
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    Cell physiology -- Neurophysiology -- Cardiovascular physiology -- Respiratory physiology -- Renal and acid-base physiology -- Gastrointestinal physiology -- Endocrine physiology.
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  • Technophysiology, evolution, and aging : towards a new image of aging / Paola S. Timiras -- Are there age-related changes in flavonoid bioavailability? / C-Y. Oliver Chen and Jeffrey B. Blumberg -- Trends in the analysis of phytochemicals : flavonoids and carotenoids / Eunmi Koh and Alyson E. Mitchell -- Anti-inflammatory botanicals : a case study of genetic screens as part of a pharmacogenomic approach / Moul Dey ... [et al.] -- Characteristics and functions of lutein and zeaxanthin within the human retina / Billy R. Hammond, Jr. and Lisa M. Renzi -- Phytochemicals and the aging brain / Stephane Bastianetto and Remi Quirion -- Green tea : skin care and skin diseases / Stephen D. Hsu -- Pomegranate phenolics antioxidant activities protect against cardiovascular diseases / Michael Aviram, Mira Rosenblat, and Bianca Fuhrman -- Customizing dietary recommendations by genotype in the era of genomics / Sina Vakili, Grace Jooyoung Shin, and Marie A. Caudill -- Development of a botanical combination product for allergy symptoms / Marc Lemay ... [et al.] -- Genotype-selective inhibition of IL-1 by botanicals : a nutrigenetics proof of principle / R. Keith Randolph.
  • "An examination of foods, botanicals, and phytochemicals as they relate to the prevention of age-related chronic diseases, this book discusses herbs and spices in cancer prevention; wine, phenolics, and cancer; anthocyanins in cardiovascular health; anti-inflammatories; skin photoprotection; beny phytochemicals; green tea catechins; and cognitive function in the elderly. The book begins with an overview of phytonutrients in human health and disease, and covers chronic disease prevention, bone and joint health, skin health, obesity and metabolism, and brain health. The final chapter describes an analytical technique 'proving very powerful in phytonutrient research in humans"--Provided by publisher.
  • Effect of Lifestyle, Aging, and Phytochemicals on the Onset of Neurological Disorders -- Beneficial Effects of Extra Virgin Olive Oil (n-9 Fatty Acids) on Neurological Disorders -- Beneficial Effects of Flaxseed Oil (n-3 Fatty Acids) on Neurological Disorders -- Beneficial Effects of Flavonoids on Neurological Disorders -- Beneficial Effects of Green Tea Catechins on Neurological Disorders -- Beneficial Effects of Curcumin on Neurological Disorders -- Beneficial Effects of Resveratrol on Neurological Disorders -- Beneficial Effects of Ginkgo biloba in Neurological Disorders -- Beneficial Effects of Garlic Components on Neurological Disorders -- Beneficial Effects of Propolis on Neurological Disorders -- Perspective and Direction for Future Research on Phytochemicals in Neurological Disorders.
  • Generic Comments on Isoflavones and Other Phytoestrogens -- Chapter 1. Brief Historical Overview of Isoflavone Research / Mark Messina -- Chapter 2. Soy Isoflavones as Functional Ingredients in Women's Health / Clare M. Hasler and Susan Kundrat -- Chapter 3. Isoflavone Supplements: Arguments For and Against Their Use / Mark Messina -- Chapter 4. Industrial Processing and Preparation of Isoflavones / Eric T Gugger -- Food Sources and Composition of Phytoestrogens -- Chapter 5. Human Dietary Sources of Phytoestrogens and Methods of Determination / Chung-Ja C. Jackson and H.P. Vasantha Rupasinghe -- Chapter 6. Tables of Isoflavone, Coumestan, and Lignan Data / Chung-Ja C. Jackson and G. Sarwar Gilani -- Measurement Methodology of Phytoestrogens in Blood and Tissues -- Chapter 7. Analysis of Phytoestrogens in Biological Samples by Mass Spectrometry / Jeevan K. Prasain, Chao-Cheng Wang, and Stephen Barnes -- Chapter 8. Measurement Methodology for Phytoestrogens in Blood and Urine / Mariko Uehara -- Chapter 9. Metabolism and Disposition of Genistein, the Principal Soy Isoflavone / Daniel R. Doerge, Richard H. Luecke, and John F Young -- Digestion, Absorption and Metabolism of Isoflavones -- Chapter 10. Digestion, Absorption and Metabolism of Isoflavones / Roger A. King -- Cellular Mechanism of Action, Including Estrogen Receptors -- Chapter 11. Cellular Mechanisms of Action Including Estrogen Receptors: ER[alpha] and [beta] / Sari Mäkelä and Jan-Åke Gustafsson -- Chapter 12. Effects of Phytoestrogens on Bone Cells: Genomic and Nongenomic Mechanisms / Xiaowei Chen and John J.B. Anderson -- Cardiovascular Effects -- Chapter 13. Epidemiology of Soy Isoflavones and Cardiovascular Disease / M.Z. Vitolins, M.S. Anthony, and G.L. Burke -- Chapter 14. Soy/Isoflavones and Risk Factors for Cardiovascular Disease / Mary S. Anthony -- Chapter 15. Soy Proteins, Isoflavones, Cardiovascular Risk Factors, and Chronic Disease / David J.A. Jenkins, Cyril WC. Kendall, and Augustine Marchie -- Chapter 16. Lipoprotein Effects of Soybean Phytoestrogens / Sandra R. Teixeira and John W Erdman, Jr. -- Chapter 17. Effects of Free (Aglycone) Phytoestrogens and Metabolites on Cardiovascular Functions and Cancer / Paul Nestel and Alan Husband -- Skeletal Effects -- Chapter 18. Association Between Soy and/or Isoflavones and Bone: Evidence from Epidemiologic Studies / Mary S. Anthony, John J.B. Anderson, and D. Lee Alekel -- Chapter 19. Skeletal Effects of Phytoestrogens in Humans: Bone Mineral Density and Bone Markers / John J.B. Anderson and D. Lee Alekel -- Chapter 20. Skeletal Effects of Phytoestrogens: Rodent Models: Diet / Bahram H. Arjmandi and Brenda J. Smith -- Cancer -- Chapter 21. Phytoestrogens and Cancer: Epidemiologic Evidence / Anna H. Wu -- Chapter 22. Flaxseed Lignans: Health Benefits, Bioavailability, and Safety / Lilian U. Thompson and Wendy E. Ward -- Chapter 23. Phytoestrogens, Estrogens and Risk of Colon Cancer / Maurice R. Bennink and Elizabeth A. Rondini -- Chapter 24. Phytoestrogen Actions in the Breast and Uterus / Charles E. Wood, Stephen Barnes, and J. Mark Cline -- Chapter 25. Induction of Apoptosis by Genistein: Potential Applications in Cancer Prevention and Treatment / Andreas I. Constantinou -- Renal Effects -- Chapter 26. Phytoestrogens: Diabetic Nephropathy / Tammy J. Stephenson and James W Anderson -- Premenopausal Hormone Effects -- Chapter 27. Hormonal Effects of Phytoestrogens in Premenopausal Women / Alison M. Duncan, William R. Phipps, and Mindy S. Kurzer -- Postmenopausal, Potential Alternative to Traditional HRT -- Chapter 28. Phytoestrogens: Effects on Menopausal Symptoms / Fabien S. Dalais -- Chapter 29. Use of Soy Isoflavones as an Alternative to Traditional Hormone Replacement Therapy / Mara Z. Vitolins, Mary S. Anthony, and Gregory L. Burke -- Safety and Potential Toxicity -- Chapter 30. Deleterious Effects of Genistein Follow Exposure During Critical Stages of Development / Retha R. Newbold, Wendy Jefferson, Elizabeth Padilla-Banks, and Bill Bullock -- Chapter 31. Evaluation of Phytoestrogen Safety and Toxicity in Rodent Models That Include Developmental Exposure / Barry Delclos -- Chapter 32. The Health Consequences of Soy Infant Formula, Soy Protein Isolate, and Isoflavones / Thomas M. Badger, Martin J.J. Ronis, Reza Hakkak, and Sohelia Korourian -- Chapter 33. Public Health Implications of Dietary Phytoestrogens / Joel Rotstein, and G. Sarwar Gilani.
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  • Pichia protocols. 2nd ed. 2007
    Springer Protocols
    Introduction : distinction between Pichia pastoris and other expression systems / James M. Cregg -- Vectors and strains for expression / Joan Lin-Cereghino and Geoff P. Lin-Cereghino -- DNA-mediated transformation / James M. Cregg -- Rational design and optimization of fed-batch and continuous fermentation / Wenhui Zhag, Mehmet Inan, and Michael M. Meagher -- Saturation of the secretory pathway by overexpression of a hookworm (Necator americanus) protein (Na-ASP1) / Mehmet Inan ... [et al.] -- Purification of the N- and C-terminal subdomains of recombinant heavy chain fragment C of botulinum neurotoxin serotype C / Jicai Huang ... [et al.] -- Rapid screening of chromatography resins for the purification of proteins / Sandra E. Ríos, Erin M. Giaccone, and Tillman U. Gerngross -- Characterization of O-linked saccharides on glycoproteins / Roger K. Bretthauer -- Modification of the N-glycosylation pathway to produce homogeneous human-like glycans using glycoswitch plasmids / Wouter Vervecken ... [et al.] -- N-linked glycan characterization of heterologous proteins / Huijan Li ... [et al.] -- Heavy labeling of recombinant proteins / Eric Rodriguez -- Selenomethionine labeling of recombinant proteins / Anna M. Larsson and T. Alwyn Jones -- Selective isotopic labeling of recombinant proteins using amino acid auxotroph strains / James W. Whittaker -- Classical genetics / Ilya Tolstorukov and James M. Cregg -- Identification of pexophagy genes by restriction enzyme-mediated integration / Laura A. Schroder, Benjamin S. Glick, and William A. Dunn, Jr. -- Characterization of protein-protein interactions : application to the understanding of peroxisome biogenesis / Sebastien Leon ... [et al.] -- Localization of proteins and organelles using fluorescence microscopy / Jean-Claude Farre ... [et al.] -- Fluorescence microscopy and thin-section electron microscopy / Benjamin S. Glick.
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    A history of the science of pigmentation / Sidney N. Klaus -- Comparative anatomy and physiology of pigment cells in nonmammalian tissues / Joseph T. Bagnara & Jiro Matsumoto -- General biology of mammalian pigmentation / Walter C. Quevedo Jr. & Thomas J. Holstein -- Extracutaneous melanocytes / Raymond E. Boissy & Thomas J. Hornyak -- Regulation of melanoblast migration and differentiation / David M. Parichy, Mark V. Reedy, & Carol A. Erickson -- Melanoblast development and associated disorders / Richard A. Spritz -- Biogenesis of melanosomes / Raymond E. Boissy, Marjan Huizing, & William A. Gahl -- Melanosome trafficking and transfer / Glynis A. Scott -- Melanosome processing in keratinocytes / H. Randolph Byers -- The regulation of melanin formation / Vincent J. Hearing -- The tyrosinase gene family / William S. Oetting & Vijayasaradhi Setaluri -- Molecular regulation of melanin formation: melanosome transporter proteins / Murray H. Brilliant -- Transcriptional regulation of melanocyte function / Kazuhisa Takeda & Shigeki Shibahara -- Enzymology of melanin formation / Francisco Solano & José C. García-Borrón -- Chemistry of melanins / Shosuke Ito & Kazumasa Wakamatsu -- The physical properties of melanins / Tadeusz Sarna & Harold A. Swartz -- Photobiology of melanins / Antony R. Young -- Toxicological aspects of melanin and melanogenesis / Edward J. Land, Christopher A. Ramsden & Patrick A. Riley -- Regulation of pigment type switching by agouti, melanocortin signaling, attractin, and mahoganoid / Gregory S. Barsh -- Human pigmentation: its regulation by ultraviolet light and by endocrine, paracrine and autocrine factors / Zalfa Abdel-Malek & Ana Luisa Kadekaro -- Paracrine interactions of melanocytes in pigmentary disorders / Genji Imokawa -- Growth factor receptors and signal transduction regulating the proliferation and differentiation of melanocytes / Ruth Halaban & Gisela Moellmann -- Aging and senescence of melanocytes / Debdutta Bandyopadhyay & Estela E. Medrano -- The genetics of melanoma / Vanessa C. Gray-Schopfer & Dorothy C. Bennett -- The transformed phenotype of melanocytes / Dong Fang & Meenhard Herlyn -- A more precise lexicon for pigmentation, pigmentary disorders, and "chromatic" abnormalities / James J. Nordlund ... [et al.] -- The normal color of human skin / James J. Nordlund & Jean-Paul Ortonne -- Mechanisms that cause abnormal skin color / Jean-Paul Ortonne & James J. Nordlund -- Genetic hypomelanoses: disorders characterized by congenital white spotting-piebaldism, Waardenburg syndrome, and related genetic disorders of melanocyte development-clinical aspects / Richard A. Spritz -- Genetic hypomelanoses: acquired depigmentation -- Genetic hypomelanoses: generalized hypopigmentation -- Genetic hypomelanoses: localized hypopigmentation -- Genetic hypomelanoses: disorders characterized by hypopigmentation of hair -- Metabolic, nutritional and endocrine disorders -- Chemical, pharmacologic and physical agents causing hypomelanoses -- Infectious hypomelanoses / Jean-Philippe Lacour-- Inflammatory hypomelanoses / Jean-Philippe Lacour -- Hypomelanoses associated with melanocytic neoplasia / Lieve Brochez, Barbara Boone, & Jean-Marie Naeyaert -- Miscellaneous hypomelanoses: depigmentation -- Miscellaneous hypomelanoses: hypopigmentation -- Miscellaneous hypomelanoses: extracutaneous loss of pigmentation -- Hypochromia without hypomelanosis / Jean-Philippe Lacour -- Genetic epidermal syndromes: disorders characterized by generalized hyperpigmentation -- Genetic epidermal syndromes: disorders characterized by reticulated hyperpigmentation -- Genetic epidermal syndromes with Café-au-Lait macules -- Genetic epidermal pigmentation with lentigines -- Genetic epidermal syndromes: localized hyperpigmentation -- Genetic epidermal syndromes: disorders of aging -- Congenital epidermal hypermelanoses -- Acquired epidermal hypermelanoses -- Hypermelanosis associated with gastrointestinal disorders -- Acquired and congenital dermal hypermelanosis -- Mixed epidermal and dermal hypermelanoses and hyperchromias -- Drug-induced or -related pigmentation -- The melanocyte system of the nails and its disorders -- Pigmentary abnormalities and discolorations of the mucous membranes / John C. Maize, Jr. & John C. Maize, Sr. -- Common benign neoplasms of melanocytes -- Rare benign neoplasms of melanocytes -- Topical treatment of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Chemophototherapy of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- UVB therapy for pigmentary disorders / Thierry Passeron & Jean-Paul Ortonne -- Sunscreens and cosmetics / James J. Nordlund & Rebat M. Halder -- Surgical treatments of pigmentary disorders / Rebat M. Halder & James J. Nordlund -- Laser treatment of pigmentary disorders / Rebat M. Halder, Lori M. Hobbs, & James J. Nordlund.
  • "Millions of people use Pilates training to improve health and fitness, or regain movement capability following injury or disease. Competent, professional support from physiotherapists, sports teachers and trainers is of vital importance for every client or patient. "Pilates: A teachers' manual“ provides you, as a professional, with fundamental teaching structures and practical guidelines. The concepts which characterized the traditional approach to Pilates are combined with the evolved methods of modern Pilates training, and backed up by current findings in sports science and kinesiology."--Publisher's website.
  • Statistical analysis of pineal tumors based on the data of brain tumor registry of Japan / Shibui, S., Nomura, K. -- Pathology of pineal parenchymal tumors / Sato, K., Kubota, T. -- Occipital transtentorial approach and combined treatments for pineal parenchymal tumors / Tsumanuma, I., Tanaka, R., Fujii, Y. -- Role of stereotactic radiosurgery in the management of pineal parenchymal tumors -- Kano, H. ... [et al.] -- Pathology of intracranial germ cell tumors / Sato, K., Takeuchi, H., Kubota, T. -- Pineal germ cell tumors / Matsutani, M. -- Strategy of combined treatment of germ cell tumors / Sawamura, Y. -- Radiation therapy for intracranial germ cell tumors / Aoyama, H. -- Stereotactic radiosurgery for pineal and related tumors / Mori, Y. ... [et al.] -- Management of central nervous system germinoma : proposal for a modern strategy / Shibamoto, Y. -- Quality of life of extremely long-time germinoma survivors mainly treated with radiotherapy / Sugiyama, K. ... [et al.].
  • "The first half of the book provides historical review, insights into the barriers women physicians face and the authors' roles promoting women in medicine. The second half focuses on authors' interactions with pioneering women in medicine or biographies about influential women physicians and scientists."--Preface.
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    This book is a history of cardiac surgery in the words of the first generation of surgeons. Heart operations today are quite common and relatively low-risk, but in the beginning it was just the opposite. Cardiac operations were reserved for desperately ill patients. The author documents this dramatic transition with profiles of 38 surgeons who were active between 1940 and 1985. The profiles are edited transcripts of interviews videotaped between 1996 and 2004. They tell of the development of new techniques such as the "blue baby operation," the first heart-lung machine, the first artificial heart valve, and the first coronary bypass operation. They also tell the unusual life stories of the surgeons and allude to professional and institutional rivalries. A particularly valuable part of the book is the author's brief history of cardiac surgery, designed to orient the reader for reading the profiles that follow. - Publisher.
  • The practice of diagnostic radiology has become increasingly complex, with the use of numerous imaging modalities and division into many subspecialty areas. It is becoming ever more difficult for subspecialist radiologists, general radiologists, and residents to keep up with the advances that are occurring year on year, and this is particularly true for less familiar topics. Failure to appreciate imaging pitfalls often leads to diagnostic error and misinterpretation, and potential medicolegal problems. Diagnostic errors may be due to various factors such as inadequate imaging technique, imaging artifacts, failure to recognize normal structures or variants, lack of correlation with clinical and other imaging findings, and poor training or inexperience. Many, if not most, of these factors are potentially recognizable, preventable, or correctable. This textbook, written by experts from reputable centers across the world, systematically and comprehensively highlights the pitfalls that may occur in diagnostic radiology. Both pitfalls specific to different modalities and techniques and those specific to particular organ systems are described with the help of numerous high-quality illustrations. Recognition of these pitfalls is crucial in helping the practicing radiologist to achieve a more accurate diagnosis.
  • Why it matters -- Tackling hospital-acquired infections -- Moving closer to the patient -- Reducing medication errors -- Eliminating the wait -- Applying best practices -- Transforming a medical specialty.
  • Pituitary apoplexy 2014
    Pituitary apoplexy is a rare and life-threatening complication that occurs in 0.6-10.5% of all patients with pituitary adenomas. Unfortunately, pituitary apoplexy is often misdiagnosed before surgery. Furthermore, in spite of all the advances in imaging techniques and therapeutic methods, its optimal management is still controversial owing to the limited individual experience and the very variable clinical course of the condition, which ranges from asymptomatic to critical illness with visual loss and subarachnoid hemorrhage. The management of visual dysfunction in particular remains a subject of debate. This book provides an in-depth review of knowledge of the management of pituitary apoplexy, with an emphasis on clinical and neuroradiological findings and treatment modalities, medical and surgical. In addition, it supplies clinicians and investigators with detailed information on current evidence and considers future areas of investigation and innovative therapeutic philosophies. Both the editors and the authors are leading international authorities in the field.
  • Section 1: overview. The endocrine system / Sylvia L Asa, Shereen Ezzat ; Signs and symptoms of pituitary disease / Eva Fernandez-Rodriguez, Ignacio Bernabeu, Felipe F Casanueva, Eva N Kassi, Gregory A Kaltsas, George P Chrousos, Valerie Golden -- Section 2: disorders. Acromegaly / Shereen Ezzat ; Secondary adrenal insufficiency / Tobias Else, Richard J Auchus ; Adult growth hormone deficiency / T Brooks Vaughan, Kristen Owen Riley, Lewis S Blevins ; Pituitary carcinoma / Sylvia L Asa ; Craniopharyngioma / Jessica K Devin ; Cushing's syndrome / Lewis S Blevins ; Empty sella syndrome / Michael C Oh, Manish K Aghi ; Familial pituitary adenomas / Laura C Hernández-Ramírez, Márta Korbonits ; Follicle stimulating hormone and luteinizing hormone secreting tumors / Bahram Khazai, Ronald S Swerdloff, Christina Wang ; Hypopituitarism / Klara J Rosenquist, Ursula B Kaiser ; Clinically nonfunctioning pituitary adenomas / Brandon A Miller, Adriana G Ioachimescu, Nelson M Oyesiku ; Prolactinoma / Luis G Sobrinho ; Rathke's cleft cysts / Seunggu J Han, Arman Jahangiri, Manish K Aghi ; Thyroid hormone deficiency / Whitney W Woodmansee ; Thyroid stimulating hormone secreting tumor / Andrea Lania, Luca Persani, Paolo Beck-Peccoz ; Pituitary disorders - specific issues for women / Maria Fleseriu, Christine G Yedinak, Jessica Brzana, Shirley McCartney ; Hypogonadism and male sexual function / Prasanth N Surampudi, Christina Wang, Ronald S Swerdloff ; Pituitary disorders specific to children / Kathryn Pade, Mitchell E Geffner -- Section 3: diagnosing pituitary disorders. Physical examination / Laurence Katznelson ; Pituitary endocrine function testing / Shereen Ezzat -- Section 4: treatment of pituitary disorders. Medical management of pituitary adenomas / Paolo Cappabianca, Daniel M Prevedello, Michelangelo de Angelis, Andressa Bornschein, Leo F S Ditzel Filho, Domenico Solari, Ricardo L Carrau, Felice Esposito, Danielle de Lara, Luigi M Cavallo, Annamaria Colao ; Surgical management of pituitary disorders / Gautam U Mehta, John A Jane, Ian F Dunn, Tong Yang, Theodore H Schwartz, Huy T Duong, Daniel F Kelly ; Stereotactic radiosurgery for pituitary adenomas / Brian J Williams, Stephen J Monteith, Jason P Sheehan ; Hormone replacement therapy / Joseph A M J L Janssen, Aart Jan van der Lely, Alan D Rogol, Adriana G Ioachimescu -- Section 5: complications that accompany pituitary disease. Complications of pituitary disease / Ludovica F S Grasso, Alessia Cozzolino, Annamaria Colao, Krystallenia I Alexandraki, Gregory A Kaltsas, George P Chrousos, Marco Faustini-Fustini, Giorgio Frank, Paul B Rizzoli, Andrea L Utz, Sashank Prasad -- Section 6: general psychological and psychosocial effects. General psychological and psychosocial effects of pituitary disorders / Valerie Golden -- Section 7: long term: what you and your patients can expect. Living with pituitary disease / Jessica K Devin -- Section 8: research and clinical trials. Research and clinical trials / Brittany P Sumerel, Anthony P Heaney -- Section 9: resources. Fundamentals of pituitary pathology / Sylvia L Asa -- Glossary -- Index.
  • Role of transcranial approaches in the treatment of sellar and suprasellar lesions / Maartens, N.F.; Kaye, A.H -- Extended transsphenoidal approach / Dumont, A.S. ... [et al.] -- Image guidance in pituitary surgery / Asthagiri, A.R.; Laws, E.R. Jr.; Jane, J.A. Jr. -- Endoscopic endonasal cavernous sinus surgery, with special reference to pituitary adenomas / Frank, G.; Pasquini, E. -- Diagnosis and management of pediatric sellar lesions / Jagannathan, J.; Dumont, A.S.; Jane, J.A. Jr. -- The craniopharyngioma / Oskouian, R.J.; Samii, A.; Laws, E.R. Jr. -- Rathke's cleft cysts / Kanter, A.S. ... [et al.] -- Treatment of Cushing's disease : a retrospective clinical study of the latest 100 cases / Hofmann, B.M.; Fahlbusch, R. -- Stereotactic radiosurgery for pituitary adenomas : a review of the literature and our experience / Sheehan, J.P. ... [et al.] -- Neuropathological considerations of pituitary adenomas / Asthagiri, A.; Lopes, M.B.S. -- Anesthetic and critical care management of patients undergoing pituitary surgery / Burton, C.M.; Nemergut, E.C. -- Vascular injury and transsphenoidal surgery / Oskouian, R.J.; Kelly, D.F.; Laws, E.R. Jr.
  • Update on basic and clinical research on pituitary function and disease.
  • Implication of pituitary tropic status on tumor development / I. Donangelo, S. Melmed -- Anterior pituitary cell renewal during the estrous cycle / M. Candolfi ... [et al.] -- Bone morphogenetic protein-4 control of pituitary pathophysiology / D. Giacomini ... [et al.] -- Genesis of prolactinomas: studies using estrogen-treated animals / D.K. Sarkar -- Dopaminergic D2 receptor knockout mouse: an animal model of prolactinoma / C. Cristina ... [et al.] -- Vasoinhibins: a family of n-terminal prolactin fragments that inhibit angiogenesis and vascular function / C. Clapp ... [et al.] -- Molecular mechanisms of pituitary differentiation and regulation: implications for hormone deficiencies and hormone resistance syndromes / J. Drouin -- Long-term follow-up of prolactinomas: should dopamine agonist treatment be life-long? / M. Guitelman -- Ghrelin: from somatotrope secretion to new perspectives in the regulation of peripheral metabolic functions / F. Broglio ... [et al.] -- Regulating of growth hormone sensitivity by sex steroids: implications for therapy / K.K.Y. Ho ... [et al.] -- Acromegaly: molecular expression of somatostatin receptor subtypes and treatment outcome / M.D. Bronstein -- Gene therapy in the neuroendocrine system / C.B. Hereñú ... [et al.] -- Ectopic ACTH syndrome / A.M. Isidori, G.A. Kaltsas, A.B. Grossman -- Estrogens and neuroendocrine hypothalamic-pituitary-adrenal axis function / A.F. De Nicola ... [et al.] -- New aspects in the diagnosis and treatment of Cushing disease / M. Labeur ... [et al.].
  • Pituitary. 3rd ed. 2011
    2011 ClinicalKey
    Chapter 1. Pituitary Development / Jacques Drouin -- Chapter 2. Hypothalamic Regulation of Anterior Pituitary Function / Anat Ben-Shlomo, Shlomo Melmed -- Chapter 3. Adrenocorticotropin / Oulu Wang, Joseph A. Majzoub -- Chapter 4. Growth Hormone / Vivien S. Herman-Bonert, Shlomo Melmed -- Chapter 5. Prolactin / Mary P. Gillam, Mark E. Molitch -- Chapter 6. Thyroid-stimulating Hormone / Virginia D. Sarapura, David F. Gordon, Mary H. Samuels -- Chapter 7. Gonadotropin Hormones / Ursula B. Kaiser -- Chapter 8. The Posterior Pituitary / Daniel G. Bichet -- Chapter 9. The Hypothalamus / Glenn D. Braunstein -- Chapter 10. Anterior Pituitary Failure / John D. Carmichael -- Chapter 11. Pituitary Function in Systemic Disorders / Harold E. Carlson -- Chapter 12. The Pituitary Gland in Pregnancy and the Puerperium / Harold E. Carlson -- Chapter 13. Drugs and Pituitary Function / Harold E. Carlson -- Chapter 14. Acromegaly / Shlomo Melmed -- Chapter 15. Prolactinoma / Mary P. Gillam, Mark E. Molitch -- Chapter 16. Cushing's disease / Xavier Bertagna, Laurence Guignat, Marie-Charles Raux-Demay, Brigitte Guilhaume, François Girard -- Chapter 17. Thyrotropin-Secreting Pituitary Tumors / Vanessa Rouach, Yona Greenman -- Chapter 18. Gonadotroph Adenomas / Peter J. Snyder -- Chapter 19. Nonpituitary Tumors of the Sellar Region / Olga Moshkin, Steffen Albrecht, Juan M. Bilbao, Kalman Kovacs -- Chapter 20. Pituitary Imaging / Marcel M. Maya, Barry D. Pressman -- Chapter 21. Pituitary Surgery / Rudolf Fahlbusch, Michael Buchfelder.
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    Pivot table fundamentals and ground rules -- Creating your first pivot table -- Customizing your pivot table -- Controlling the way you view your pivot data -- Performing calculations within your pivot tables -- Creating and using pivot charts -- Analyzing disparate data sources with pivot tables -- Taking your pivot tables to the web -- Working with and analyzing olap data sources -- Enhancing pivot reports with macros -- Using vba to create pivot tables -- Common pivot table issues and questions -- A pivot table function map.
  • The history of public health has focused on direct relationships between problems and solutions: vaccinations against diseases, ad campaigns targeting risky behaviors. But the accelerating pace and mounting intricacies of our lives are challenging the field to find new scientific methods for studying community health. The complexities of place (COP) approach is emerging as one such promising method. ℗ℓ Place and Health as Complex Systems demonstrates how COP works, making an empirical case for its use in for designing and implementing interventions. This brief resource reviews the defining characteristics of places as dynamic and evolving social systems, rigorously testing them as well as the COP approach itself. The study, of twenty communities within one county in the Midwest, combines case-based methods and complexity science to determine whether COP improves upon traditional statistical methods of public health research. Its conclusions reveal strengths and limitations of the approach, immediate possibilities for its use, and challenges regarding future research. Included in the coverage: ℗ℓ Characteristics of places and the complexities of place approach. The Definitional Test of Complex Systems. Case-based modeling using the SACS toolkit. Methods, maps, and measures used in the study. Places as nodes within larger networks. Places as power-based conflicted negotiations. ℗ℓ Place and Health as Complex Systems brings COP into greater prominence in public health research, and is also valuable to researchers in related fields such as demography, health geography, community health, urban planning, and epidemiology. ℗ℓ
  • Placebo 2014
    Due to the recent explosion of placebo research at many levels the Editors believe that a volume on Placebo would be a good addition to the Handbook of Experimental Pharmacology series. In particular, this volume will be built up on a meeting on Placebo which will be held in Tuebingen (Germany) in January 2013, and where the most prominent researchers in this field will present and exchange their ideas. The authors who will be invited to write chapters for this volume will be the very same speakers at this meeting, thus guaranteeing high standard and excellence in the topic that will be treated. The approach of the book is mainly pharmacological, including basic research and clinical trials, and the contents range from different medical conditions and systems, such as pain and the immune system, to different experimental approaches, like in vivo receptor binding and pharmacological/behavioral conditioning. Overall, the volume will give an idea of modern placebo research, of timely concepts in both experimental and clinical pharmacology, as well as of modern methods and tools in neuroscience.
  • 1. Historical aspects of placebo analgesia / Damien Finniss -- 2. Neurochemistry of placebo analgesia : opioids, cannabinoids and cholecystokinin / Fabrizio Benedetti, Elisa Frisaldi -- 3. Placebo analgesia in rodents / Jian-You Guo, Jin-Yan Wang, Fei Luo -- 4. Molecular mechanisms of placebo responses in humans / Marta Pecina, Jon-Kar Zubieta -- 5. How does EEG contribute to our understanding of the placebo response? / Anthony Jones, Christopher Brown, Wael El-Deredy -- 6. Spinal mechanisms of placebo analgesia and nocebo hyperalgesia : descending inhibitory and facilitatory influences / Serge Marchand -- 7. Spinal and supraspinal mechanisms of placebo analgesia / Falk Eippert, Christian Buchel -- 8. Positive and negative emotions and placebo analgesia / Magne Arve Flaten, Per M. Aslaksen, Peter S. Lyby -- 9. Placing placebo in normal brain function with neuroimaging / Martin Ingvar, Predrag Petrovic, Karin Jensen -- 10. Brain predictors of individual differences in placebo responding / Leonie Koban, Luka Ruzic, Tor D. Wager -- 11. Placebo responses, antagonistic responses, and homeostasis / Magne Arve Flaten -- 12. Placebo analgesia, nocebo hyperalgesia, and acupuncture / Jian Kong, Randy L. Gollub -- 13. The relevance of placebo and nocebo mechanisms for analgesic treatments / Ulrike Bingel -- 14. How placebo responses are formed : from bench to bedside / Luana Colloca -- 15. Methodologic aspects of placebo research / Magne Arve Flaten, Karin Meissner, Luana Colloca -- 16. Balanced placebo design, active placebos, and other design features for identifying, minimizing and characterizing the placebo response / Paul Enck, Katja Weimer, Sibylle Klosterhalfen -- 17. Psychological processes that can bias responses to placebo treatment for pain / Ben Colagiuri, Peter F. Lovibond -- 18. Against 'placebo' : the case for changing our language, and for the meaning response / Daniel E. Moerman -- 19. Placebo effects in complementary and alternative medicine : the self-healing response / Harald Walach -- 20. Conceptualizations and magnitudes of placebo analgesia effects across meta-analyses and experimental studies / Lene Vase, Gitte Laue Petersen -- 21. The contribution of desire, expectation, and reduced negative emotions to placebo anti-hyperalgesia in irritable bowel syndrome / Donald D. Price, Lene Vase -- 22. The wound that heals : placebo, pain and surgery / Wayne B. Jonas [and three others] -- 23. What are the best placebo interventions for the treatment of pain? / Karin Meissner, Klaus Linde -- 24. How communication between clinicians and patients may impact pain perception / Arnstein Finset -- 25. Nocebos in daily clinical practice / Bettina K. Doering, Winfried Rief -- 26. The potential of the analgesic placebo effect in clinical practice -- recommendations for pain management / Regine Klinger, Herta Flor -- 27. Placebo and nocebo : ethical challenges and solutions / Luana Colloca, Franklin G. Miller.
  • v. 2 Springer Protocols
  • "This is the first systematic scholarly study of the Ottoman experience of plague during the Black Death pandemic and the centuries that followed. Using a wealth of archival and narrative sources, including medical treatises, hagiographies, and travelers' accounts, as well as recent scientific research, Nükhet Varlik demonstrates how plague interacted with the environmental, social, and political structures of the Ottoman Empire from the late medieval through the early modern era. The book argues that the empire's growth transformed the epidemiological patterns of plague by bringing diverse ecological zones into interaction and by intensifying the mobilities of exchange among both human and non-human agents. Varlik maintains that persistent plagues elicited new forms of cultural imagination and expression, as well as a new body of knowledge about the disease. In turn, this new consciousness sharpened the Ottoman administrative response to the plague, while contributing to the makings of an early modern state"-- Provided by publisher.
  • History, classification and cultivation of the planctomycetes / Cheryl Jenkins and James T. Staley -- Cell compartmentalization and endocytosis in planctomycetes: structure and function in complex bacteria / John A. Fuerst, Richard I. Webb, and Evgeny Sagulenko -- Structural aspects of MC proteins of PVC superphylum members / Damien P. Devos -- Cell biology of anaerobic ammonium-oxidizing bacteria: unique prokaryotes with an energy-conserving intracellular compartment / Sarah Neumann, Muriel C.F. van Teeseling and Laura van Niftrik -- Acidophilic planctomycetes: expanding the horizons of new planctomycete diversity / Svetlana N. Dedysh and Irina S. Kulichevskaya -- Toward the development of genetic tools for Planctomycetes / Mareike Jogler and Christian Jogler -- Genomics and bioinformatics of the PVC superphylum / Olga K. Kamneva, Daniel H. Haft, Stormy J. Knight, Davide A. Liberles, and Naomi L. Ward -- Distribution and evolution of C1 transfer enzymes and evolution of the planctomycetes / Ludmila Chistoserdova -- Unusual members of the PVC superphylum: the methanotrophic Verrucomicrobia genus "Methylacidiphilum" / Christine E. Sharp, Huub J.M. Op den Camp, Ivica Tamas, and Peter F. Dunfield -- Phyla related to Planctomycetes: members of phylum Chlamydiae and their implications for Planctomycetes cell biology / Claire Bertelli and Gilbert Greub -- Planctomycetes: their evolutionary implications for models for origins of eukaryotes and the eukaryote nucleus and endomembranes / John A. Fuerst and Evgeny Sagulenko -- Final word: the future of planctomycetology and related studies / John A. Fuerst -- Index.
  • Print Material
  • The EMBL nucleotide sequence and genome reviews databases / Peter Sterk ... [et al.] -- Using GenBank / David Wheeler -- A collection of plant-specific genomic data and resources at NCBI / Tatiana Tatusova, Brian Smith-White, and James Ostell -- UniProtKB/Swiss-Prot / Emmanuel Boutet ... [et al.] -- Plant database resources at The Institute for Genomic Research / Agnes P. Chan... [et al.] -- MIPS plant genome information resources / Manuel Spannagl ...[et al.] -- HarvEST / Timothy J. Close ... [et al.] -- The TAIR database / Rebecca L. Poole -- AtEnsEMBL / Nick James ... [et al.] -- Accessing integrated Brasica genetic and genomic data using the BASC server / Christopher G. Love and David Edwards -- Leveraging model legume information to find candidate genes for soybean sudden death syndrome using the Legume Information System / Michael D. Gonzales ... [et al.] -- Legume resources : MtDB and / Ernest F. Retzel ... [et al.] -- BGI-RIS V2 / Ximiao He and Jun Wang -- GrainGenes / Helen O'Sullivan -- Gramene / Doreen Ware -- MaizGDB / Carolyn J. Lawrence -- BarleyBase/PLEXdb / Roger P. Wise ... [et al.] -- Reaping the benefits of SAGE / Stephen J. Robinson ... [et al.] -- Methods for analysis of gene expression in plants using MPSS / Kan Nobuta, Kalyan Vemaraju, and Blake C. Meyers -- Metabolomics data analysis, visualization, and integration / Lloyd W. Sumner, Ewa Urbanczyk-Wochniak, and Corey D. Broeckling -- KEGG bioinformatics resource for plant genomics research / Ali Masoudi-Nejad ... [et al.] -- International Crop Information System for germplasms data management / Arllet Portugal ... [et al.] -- Automated discovery of single nucleotide polymorphism and simple sequence repeat molecular genetic markers / Jacqueline Batley, Erica Jewell, and David Edwards -- Methods for gene ontology annotation / Emily Dimmer ... [et al.] -- Gene structure annotation at PlantGDB / Volker Brendel -- An introduction to BioPerl / Jason E. Stajich.
  • Plant tissue cultures / Anna Karkonen [and others] -- Computerized molecular modeling of carbohydrates / Alfred D. French and Glenn P. Johnson -- Oligosaccharide mass profiling (OLIMP) of cell wall polysaccharides by MALDI-TOF/MS / Markus Gunl, Florian Kraemaer, and Markus Pauly -- High-voltage paper electrophoresis (HVPE) of cell-wall building blocks and their metabolic precursors / Stephen C. Fry -- Carbohydrate gel electrophoresis / Florence Goubet, Paul Dupree, and Katja Salomon Johansen -- Monoclonal antibodies, carbohydrate-binding modules, and the detection of polysaccharides in plant cell walls / Cecile Herve, Susan E. Marcus, and J. Paul Knox -- Screening and characterization of plant cell walls using carbohydrate microarrays / Iben Sorensen and William G.T. Willats -- Electron tomography and immunogold labelling as tools to analyse de novo assembly of plant cell walls / Marisa S. Otegui -- Analysing cellulose biosynthesis with confocal microscopy / Meera Nair and Seth DeBolt -- Visual mapping of cell wall biosynthesis / Yumiko Sakuragi, Morten H.H. Norholm, and Henrick V. Scheller -- Atomic force microscopy of plant cell walls / Andrew R. Kirby -- Using solid-state 13C NMR spectroscopy to study the molecular organization of primary plant cell walls / Tracey J. Bootten [and others] -- Formation of cellulose-based composites with hemicelluloses and pectins using gluconacetobacter fermentation / Deirdre Mikkelsen and Michael J. Gidley -- Structural proteins of the primary cell wall : extraction, purification, and analysis / Derek T.A. Lamport, Li Tan, and Marcia J. Kieliszewski -- New insights into the control of cell growth / Claudia Blaukopf, Matthaus Z. Krol, and Georg J. Seifert -- Extraction and detection of Arabinogalactan proteins / Zoe A. Popper -- Characterization of plant cell wall proteome using high-throughput screens / Sang-Jik Lee and Jocelyn K.C. Rose -- Knocking out the wall : protocols for gene targeting in Physcomitrella patens / Alison W. Roberts [and others] -- Measuring in vitro extensibility of growing plant cell walls / Daniel J. Cosgrove.
  • Plant chromosome engineering 2011
    Springer Protocols
    Recent advances in plant transformation -- Engineering the plastid genome of nicotiana sylvestris, a diploid model species for plastid genetics -- Homologous recombination in plants : An antireview -- Chromosome painting for plant biotechnology -- Plant B chromosomes -- Telomere truncation in plants -- Engineered plant minichromosomes -- Method for bxb1-mediated site-specific integration in planta -- Targeted mutagenesis in arabidopsis using zinc-finger nucleases -- Vectors and methods for hairpin RNA and artificial microRNA-mediated gene silencing in plants -- Recombinant protein expression in nicotiana -- Chromosome analysis and sorting using flow cytometry -- Super-stretched pachytene chromosomes for plant molecular cytogenetic mapping -- Cytological dissection of the triticeae chromosomes by the gametocidal system -- Development and use of oat-maize chromosome additions and radiation hybrids -- Enhancer trapping in plants -- Chromatin beacons : Global sampling of chromatin physical properties using chromatin charting lines -- Transposable elements as catalysts for chromosome rearrangements.
  • Growth protocols for model plants in developmental biology / Lars Hennig -- Grafting as a research tool / Colin G.N. Turnbull -- Virus-induced gene silencing as a reverse genetics tool to study gene function / Steven Bernacki ... [et al.] -- The CRE/lox system as a tool for developmental studies at the cell and tissue level / Guy Wachsman and Renze Heidstra -- Inducible gene expression systems for plants / Lorenzo Borghi -- Trichome development in Arabidopsis / Joachim F. Uhrig and Martin Hülskamp -- Phenotyping the development of leaf area in Arabidopsis thaliana / Sarah J. Cookson ... [et al.] -- Analyzing shoot apical meristem development / Cristel C. Carles ... [et al.] -- Analyzing floral meristem development / Elisa Fiume ... [et al.] -- Female gametophytic mutants : diagnosis and characterization / Ronny Völz and Rita Gross-Hardt -- Pollen tube development / Mark A. Johnson and Benedikt Kost -- Analysis of root meristem size development / Serena Perilli and Sabrina Sabatini -- Phenotypic characterization of photomorphogenic responses during plant development / Thomas Kretsch -- Kinematic analysis of cell division and expansion / Bart Rymen ... [et al.] -- Flowering time control / Yvonne Möller-Steinbach, Cristina Alexandre, and Lars Hennig -- mRNA detection by whole mount in situ hybridization (WISH) or sectioned tissue in situ hybridization (SISH) in Arabidopsis / Yvonne Stahl and Rüdiger Simon -- Immunolocalization of proteins in plants / Michael Sauer and Jiří Friml -- Detection of small non-coding RNAs / Tamas Dalmay -- Quantitative real time PCR in plant developmental biology / Vivien Exner -- Luciferase and green fluorescent protein reporter genes as tools to determine protein abundance and intracellular dynamics / András Viczián and Stefan Kircher -- Fluorescence-activated cell sorting in plant developmental biology / Anjali S. Iyer-Pascuzzi and Philip N. Benfey -- Laser microdissection of paraffin-embedded plant tissues for transcript profiling / Robert C. Day -- Utilizing bimolecular fluorescence complementation (BiFC) to assay protein-protein interaction in plants / Nir Ohad and Shaul Yalovsky -- The split luciferase complementation assay / Naohiro Kato and Jason Jones -- Co-immunoprecipitation and protein blots / Erika Isono and Claus Schwechheimer -- Probing protein-protein interactions with FRET-FLIM / Christoph Bücherl ... [et al.] -- Plant chromatin immunoprecipitation / Corina B.R. Villar and Claudia Köhler -- Immunocytological analysis of chromatin in isolated nuclei / Penka Pavlova ... [et al.] -- Bisulphite sequencing of plant genomic DNA / Ernst Aichinger and Claudia Köhler.
  • Zygotic embryo culture : an overview / Tegan M. Haslam and Edward C. Yeung -- In vitro fertilization with rice gametes: production of zygotes and zygote and embryo culture / Takashi Okamoto -- Canola zygotic embryo culture / Nicole S. Ramesar-Fortner and Edward C. Yeung -- Immature seeds and embryos of Medicago truncatula cultured in vitro / Sergio J. Ochatt -- In vitro culture and germination of terrestrial asian orchid seeds / Yung-I. Lee -- In vitro culture of coconut (Cocos nucifera L.) zygotic embryos / Florent Engelmann, Bernard Malaurie, and Oulo N'Nan -- Immature embryo rescue and culture / Xiuli Shen, Fred G. Gmitter, Jr., and Jude W. Grosser -- Chickpea hybridization using in vitro techniques / Nalini Mallikarjuna and Fred J. Muehlbauer -- Muskmelon embryo rescue techniques using in vitro embryo culture / Hector Gordon Nunez-Palenius, Rafael Ramirez-Malagon, and Neftali Ochoa-Alejo -- Phaseolus immature embryo rescue technology / Pascal Geerts ... [et al.] -- Wide crossing in lentil through embryo rescue / Richard Fratini and Maria L. Ruiz -- Generation of interspecific hybrids of Trifolium using embryo rescue techniques / Ajoy Kumar Roy, Devendra Ram Malaviya and Pankaj Kaushal -- Cryopreservation of embryos : an overview / Florent Engelmann -- Cryogenic technologies for the long-term storage of Citrus germplasm / Anna De Carlo, Maurizio Lambardi, and Elif Aylin Ozudogru -- Cryopreservation of zygotic embryonic axes and somatic embryos of european chestnut / Ana M. Vieitez, M. Carmen San-Jose and Elena Corredoira -- Cryopreservation of Ilex immature zygotic embryos / Luis Mroginski ... [et al.] -- Use of zygotic embryos as explants for in vitro propagation : an overview / Mohamed Elhiti and Claudio Stasolla -- Somatic embryogenesis and plant regeneration in the culture of Arabidopsis thaliana (L.) heynh. immature zygotic embryos / Malgorzata D. Gaj -- Pine somatic embryogenesis using zygotic embryos as explants / Gerald S. Pullman and Kylie Bucalo -- Micropropagation of Phalaenopsis orchids via protocorms and protocorm-like bodies / Kee Yoeup Paek, Eun Joo Hahn, and So Young Park -- Genetic transformation protocols using zygotic embryos as explants : an overview / Muhammad Tahir, Ejaz A. Waraich, and Claudio Stasolla -- Genetic transformation using maize immature zygotic embryos / Bronwyn Frame ... [et al.] -- Biolistic-mediated transformation protocols for maize and pearl millet using pre-cultured immature zygotic embryos and embryogenic tissue / Martha M. O'Kennedy, Hester C. Stark and Nosisa Dube -- Agrobacterium tumefaciens-mediated genetic transformation of cereals using immature embryos / Ashok K. Shrawat and Allen G. Good.
  • Plant embryogenesis 2008
    Springer Protocols
    Arabidopsis embryogenesis / Soomin Park and John J. Harada -- Maize embryogenesis / Pilar Fontanet and Carlos M. Vicient -- Spruce embryogenesis / Sara von Arnold and David Clapham -- In vitro fertilization with isolated higher plant gametes / Erhard Kranz, Yoichiro Hoshino, and Takashi Okamoto -- In vitro culture of Arabidopsis embryos / Michael Sauer and Jiří Friml -- Culture and time-lapse tracking of barley microspore-derived embryos / Simone de F. Maraschin ... [et al.] -- Isolation of embryo-specific mutants in Arabidopsis : plant transformation / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Isolation of embryo-specific mutants in Arabidopsis : genetic and phenotypic analysis / Nai-You Liu, Zhi-Feng Zhang, and Wei-Cai Yang -- Laser-capture microdissection to study global transcriptional changes during plant embryogenesis / Stuart A. Casson, Matthew W.B. Spencer, and Keith Lindsey -- Promoter trapping system to study embryogenesis / Robert Blanvillain and Patrick Gallois -- Visualization of auxin gradients in embryogenesis / Michael Sauer and Jiří Friml -- Intercellular trafficking of macromolecules during embryogenesis / Insoon Kim and Patricia C. Zambryski -- Immunolocalization of proteins in somatic embryos : applications for studies on the cytoskeleton / Andrei P. Smertenko and Patrick J. Hussey -- Detection of programmed cell death in plant embryos / Lada H. Filonova, María F. Suárez, and Peter V. Bozhkov.
  • Plant genomes 2008
    Paleopolyploidy and its impact on the structure and function of modern plant genomes / A.H. Paterson -- Genomic history and gene family evolution in angiosperms: challenges and opportunities / J. Sampedro, D. Cosgrove -- The evolutionary position of subfunctionalization, downgraded / M. Freeling -- Grass genome structure and evolution / J. Messing, J.L. Bennetzen -- Phylogenetic insights into the pace and pattern of plant genome size evolution / C.E. Grover, J.S. Hawkins, J.F. Wendel -- Plant transposable elements / J.M. Deragon, J.M. Casacuberta, O. Panaud -- Plant sex chromosomes / D. Charlesworth -- Plant centromeres / J.C. Lamb ... [et al.] -- MiRNAs in the plant genome: all things great and small / B.C. Meyers, P.J. Green, C. Lu -- Recent insights into the evolution of genetic diversity of maize / A. Rafalski, S. Tingey -- The rice genome structure as a trail from the past to beyond / T. Sasaki.
  • Role of model plant species / Richard Flavell -- New technologies for ultra-high throughput genotyping in plants / Nikki Appleby, David Edwards, and Jacqueline Batley -- Genetic maps and the use of synteny / Chris Duran, David Edwards, and Jacqueline Batley -- A simple TAE-based method to generate large insert BAC libraries from plant species / Bu-Jun Shi, J. Perry Gustafson, and Peter Langridge -- Transcript profiling and expression level mapping / Elena Potokina, Arnis Druka, and Michael J. Kearsey -- Methods for functional proteomic analyses / Christof Rampitsch and Natalia V. Bykova -- Stable transformation of plants / Huw D. Jones and Caroline A. Sparks -- Transient transformation of plants / Huw D. Jones, Angela Doherty, and Caroline A. Sparks -- Bridging the gene-to-function knowledge gap through functional genomics / Stephen J. Robinson and Isobel A.P. Parkin -- Heterologous and cell-free protein expression systems / Naser Farrokhi ... [et al.] -- Functional genomics and structural biology in the definition of gene function / Maria Hrmova and Geoffrey B. Fincher -- In situ analysis of gene expression in plants / Sinéad Drea ... [et al.] -- Plant and crop databases / David E. Matthews, Gerard R. Lazo, and Olin D. Anderson -- Plant genome annotation methods / Shu Ouyang ... [et al.] -- Molecular plant breeding : methodology and achievements / Rajeev K. Varshney ... [et l.] -- Practical delivery of genes to the marketplace / David A. Fischhoff and Molly N. Cline -- Ecological genomics of natural plant populations : the Israeli perspective / Eviatar Nevo -- Genome sequencing approaches and successes / Michael Imelfort ... [et al.]
  • 1. Using reverse genetics to develop small knockout collections for specific biological questions / J. Northey and P. McCourt -- 2. Visualizing auxin transport routes in Arabidopsis leaf primordial / Danielle Marcos and Thomas Berleth -- 3. Gene expression analyses for elucidating mechanisms of hormonal action in plants / George W. Bassel and Nicholas J. Provart -- 4. Measurement of plant hormones by liquid chromatography-mass spectrometry / Stacey J. Owen and Suzanne R. Abrams -- 5. Measurement of abscisic acid and gibberellins by gas chromatography/mass spectrometry / Masanori Okamoto ... [et al.] -- 6. Pull-down assays for plant hormone research / Stefab Kepinski -- 7. Binding assays for brassinosteroid receptors / Ana Caño-Delgado and Zhi-Yong Wang -- 8. Binding assays for abscisic acid receptors / Fawzi A. Razem and Robert D. Hill -- 9. Cytokinin sensing systems using microorganisms / Masayuki Higuchi, Tatsuo Kakimoto and Takeshi Mizuno -- 10. Hormone-binding assay using living bacteria expressing eukaryotic receptors / Georgy A. Romanov and S.N. Lomin -- 11. Discovery of plant microRNAs and short-interfering RNAs by deep parallel sequencing / Padmanabhan Chellappan and Hailing Jin -- 12. The use of chemical genomics to investigate pathways intersecting auxin-dependent responses and endomembrane trafficking in Arabidopsis thaliana / Lorena Norambuena, Glenn R. Hicks and Natasha V. Raikhel.
  • Studying NB-LRR immune receptor localization by agroinfiltration transient expression / Patrick Cournoyer and S.P. Dinesh-Kumar -- Fragment complementation and co-immunoprecipitation assays for understanding R protein structure and function / Peter Moffett -- Purification of resistance protein complexes using a biotinylated affinity (HPB) tag / Yiping Qi and Fumiaki Katagiri -- Biochemical purification of native immune protein complexes / James M. Elmore and Gitta Coaker -- Chromatin immunoprecipitation to identify global targets of WRKY transcription factor family members involved in plant immunity / Mario Roccaro and Imre E. Somssich -- Dose-response to and systemic movement of dexamethasone in the GVG-inducible transgene system in Arabidopsis / Xueqing Geng and David Mackey -- Quantifying alternatively spliced mRNA via capillary electrophoresis / Xue-Cheng Zhang and Walter Gassmann -- Constructing haustorium-specific cDNA libraries from rust fungi / Ann-Maree Catanzariti [and others] -- Microaspiration of esophageal gland cells and cDNA library construction for identifying parasitism genes of plant-parasitic nematodes / Richard S. Hussey, Guozhong Huang, and Rex Allen -- Construction of Pseudomonas syringae pv. tomato DC3000 mutant and polymutant strains / Brian H. Kvitko and Alan Collmer -- A straightforwward protocol for electro-transformation of Phytophthora capsici zoospores / Edgar Huitema, Matthew Smoker, and Sophien Kamoun -- Propagation, storage, and assays with Hyaloperonospora arabidopsidis : a model oomycete pathogen of Arabidopsis / John M. McDowell [and others] -- Assaying effector function in planta using double-barreled particle bombardment / Shiv D. Kale and Brett M. Tyler -- Assays for effector-mediated suppression of programmed cell death in yeast / Yuanchao Wang and Qian Huang -- Purification in effector-target protein complexes via transient expression in Nicotiana benthamiana / Joe Win, Sophien Kamoun, and Alexandrea M.E. Jones -- Imaging fluorescently tagged Phytophthora effector proteins inside infected plant tissue / Petra C. Boevink, Paul R.J. Birch, and Stephen C. Whisson -- Immunolocalization of pathogen effectors / Eric Kemen, Kurt Mendgen, and Ralf T. Voegele -- Laser capture microdissection of nematode feeding cells / Nagabhushana Ithal and Melissa G. Mitchum -- Laser microdissection of plant-fungus interaction sites and isolation of RNA for downstream expression profiling / Divya Chandran, Noriko Inada, and Mary C. Wildermuth -- Global expression profiling of RNA from laser microdissected cells at fungal-plant interaction sites / Divya Chandran, Greg Hather, and Mary C. Wildermuth -- Visualizing cellular dynamics in plant-microbe interactions using fluorescent-tagged proteins / William Underwood, Serry Koh, and Shauna C. Somerville.
  • Plant lipid signaling protocols 2013
    Springer Protocols
    As scientist begin to understand the complexity of lipid signaling and its roles in plant biology, there is an increasing interest in their analysis. Due to the low abundancy and transient nature of some of these hydrophobic compounds, this is not always easy. In Plant Lipid Signaling Protocols, expert researchers in the field detail experimental approaches by which plant signaling lipids can be studied. These methods and techniques include analysis of plant signaling lipids, including detailed protocols to detect various relevant compounds by targeted or non-targeted approaches; to assay relevant enzyme activities in biological material or using recombinant enzymes; to test for specific binding of signaling lipids to protein partners; or to visualize signaling lipids or lipid-derived signals in living plant cells. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and key tips on troubleshooting and avoiding known pitfalls. Authoritative and practical, Plant Lipid Signaling Protocols aids plant researchers in the continuing to study the roles of lipid signals.
  • Plant metabolomics 2006
  • v. 1. The Background.
  • Plant proteomics 2007
  • Total protein extraction with TCA-acetone / Valérie Méchin, Catherine Damerval, and Michel Zivy -- Phenol extraction of proteins for proteomic studies of recalcitrant plant tissues / Mireille Faurobert, Esther Pelpoir, and Jamila Chaïb -- Protein extraction from cereal seeds / Gérard Branlard and Emmanuelle Blancel -- Protein extraction from xylem and phloem sap / Julia Kehr and Martijn Rep -- Protein extraction from woody plants / Christophe Plomion and Céline Lalanne -- Isolation of chloroplast proteins from Arabidopsis thaliana for proteome analysis / Klaas J. van Wijk, Jean-Benoit Peltier, and Lisa Giacomelli -- Isolation and subfractionation of plant mitochondria for proteomic analysis / Holger Eubel, Joshua L. Heazlewood, and A. Harvey Millar -- Extraction of nuclear proteins from root meristematic cells / Fernando González-Camacho and Francisco Javier Medina -- Isolation of nuclear proteins / Setsuko Komatsu -- Isolation of cell wall proteins from Medicago sativa stems / Bonnie S. Watson and Lloyd W. Sumner -- Plant plasma membrane protein extraction and solubilization for proteomic analysis / Véronique Santoni -- Detergents and chaotropes for protein solubilization before two-dimensional electrophoresis / Thierry Rabilloud ... [et al.] -- Two-dimensional electrophoresis for plant proteomics / Walter Weiss and Angelika Görg -- Visible and fluorescent staining of two-dimensional gels / François Chevalier, Valérie Rofidal, and Michel Rossignol -- Two-dimensional differential in-gel electrophoresis (DIGE) of leaf and roots of Lycopersicon esculentum / Matthew Keeler ... [et al.] -- Quantitative analysis of 2D gels / Michel Zivy -- Multivariate data analysis of proteome data / Kåre Engkilde, Susanne Jacobsen, and Ib Søndergaard -- Edman sequencing of plant proteins from 2D gels / Setsuko Komatsu -- Peptide mass fingerprinting: identification of proteins by MALDI-TOF / Nicolas Sommerer, Delphine Centeno, and Michel Rossignol -- Protein identification using nano liquid chromatography-tandem mass spectrometry / Luc Negroni -- Two-dimensional nanoflow liquid chromatography-tandem mass spectrometry of proteins extracted from rice leaves and roots / Linda Breci and Paul A. Haynes -- Separation, identification, and profiling of membrane proteins by GFC/IEC/SDS-PAGE and MALDI TOF MS / Wojciech Szponarski ... [et al.] -- The PROTICdb database for 2-DE proteomics / Olivier Langella, Michel Zivy, and Johann Joets -- Identification of phosphorylated proteins / Maria V. Turkina and Alexander V. Vener -- Plant proteomics and glycosylation / Anne-Catherine Fitchette ... [et al.] -- Blue-native gel electrophoresis for the characterization of protein complexes in plants / Jesco Heinemeyer, Dagmar Lewejohann, and Hans-Peter Braun -- Electroelution of intact proteins from SDS-PAGE gels and their subsequent MALDI-TOF MS analysis / Zhentian Lei ... [et al.] -- Generation of plant protein microarrays and investigation of antigen-antibody interactions / Birgit Kersten and Tanja Feilner -- Phosphorylation studies using plant protein microarrays / Tanja Feilner and Birgit Kersten.
  • Analysis of High-Throughput Sequencing Data / Shrinivasrao P. Mane, Thero Modise, Bruno W. Sobral -- Identification of Plant microRNAs Using Expressed Sequence Tag Analysis / Taylor P. Frazier, Baohong Zhang -- Microarray Data Analysis / Saroj K. Mohapatra, Arjun Krishnan -- Setting Up Reverse Transcription Quantitative-PCR Experiments / Madana M. Ambavaram, Andy Pereira -- Virus-Induced Gene Silencing in Nicotiana benthamiana and Other Plant Species / Andrew Hayward, Meenu Padmanabhan, S. P. Dinesh-Kumar -- Agroinoculation and Agroinfiltration: Simple Tools for Complex Gene Function Analyses / Zarir Vaghchhipawala, Clemencia M. Rojas, Muthappa Senthil-Kumar, Kirankumar S. Mysore -- Full-Length cDNA Overexpressor Gene Hunting System (FOX Hunting System) / Mieko Higuchi, Youichi Kondou, Takanari Ichikawa, Minami Matsui -- Activation Tagging with En/Spm-I /dSpm Transposons in Arabidopsis / Nayelli Marsch-Martínez, Andy Pereira -- Activation Tagging and Insertional Mutagenesis in Barley / Michael A. Ayliffe, Anthony J. Pryor -- Methods for Rice Phenomics Studies / Chyr-Guan Chern, Ming-Jen Fan, Sheng-Chung Huang, Su-May Yu, Fu-Jin Wei, Cheng-Chieh Wu, Arunee Trisiriroj, Ming-Hsing Lai, Shu Chen, Yue-Ie C. Hsing -- Development of an Efficient Inverse PCR Method for Isolating Gene Tags from T-DNA Insertional Mutants in Rice / Sung-Ryul Kim, Jong-Seong Jeon, Gynheung An -- Transposon Insertional Mutagenesis in Rice / Narayana M. Upadhyaya, Qian-Hao Zhu, Ramesh S. Bhat -- Reverse Genetics in Medicago truncatula Using Tnt1 Insertion Mutants / Xiaofei Cheng, Jiangqi Wen, Million Tadege, Pascal Ratet, Kirankumar S. Mysore -- Screening Arabidopsis Genotypes for Drought Stress Resistance / Amal Harb, Andy Pereira -- Protein Tagging for Chromatin Immunoprecipitation from Arabidopsis / Stefan Folter -- Yeast One-Hybrid Screens for Detection of Transcription Factor DNA Interactions / Pieter B. Ouwerkerk, Annemarie H. Meijer -- Plant Metabolomics by GC-MS and Differential Analysis / Joel L. Shuman, Diego F. Cortes, Jenny M. Armenta, Revonda M. Pokrzywa, Pedro Mendes, Vladimir Shulaev -- Gramene Database: A Hub for Comparative Plant Genomics / Pankaj Jaiswal.
  • Plant secondary metabolites 2007
    Springer Protocols
  • Multiple dimensions in plant signal transduction : an overview / Jorge J. Casal -- Phenotyping of Arabidopsis mutants for developmental effects of gene deletions / Cordelia Bolle -- Phenotyping of abiotic responses and hormone treatment in Arabidopsis / Cordelia Bolle -- Accurate real-time reverse transcription quantitative PCR / Marco Klatte and Petra Bauer -- Probing spatio-temporal intracellular calcium variations in plants / Axel Mithöfer, Christian Mazars, and Massimo E. Maffei -- Dynamic redox measurements with redox-sensitive GFP in plants by confocal laser scanning microscopy / Andreas J. Meyer and Thorsten Brach -- Imaging reactive oxygen species in vivo / Steven M. Driever ... [et al.] -- Identification of thioredoxin targeted proteins using thioredoxin single cysteine mutant-immobilized resin / Ken Motohashi, Patrick G.N. Romano, and Toru Hisabori -- Determination of in vivo protein phosphorylation in photosynthetic membranes / Julia P. Vainonen, Alexander V. Vener, and Eva-Mari Aro -- Examining protein stability and its relevance for plant growth and development / Claus Schwechheimer ... [et al.] -- Probing circadian rhythms in Chlamydomonas rheinhardtii by functional proteomics / Volker Wagner and Maria Mittag -- Bimolecular fluorescence complementation (BiFC) to study protein-protein interactions in living plant cells / Katia Schütze, Klaus Harter, and Christina Chaban -- Fluorescence cross-correlation spectroscopy of plant proteins / Hideki Muto, Masataka Kinjo, and Kotaro T. Yamamoto -- The determination of protein-protein interactions by the mating-based split-ubiquitin-system (mbSUS) / Christopher Grefen, Petr Obrdlik, and Klaus Harter -- Functional complementation of yeast mutants to study plant signalling pathways / Norbert Mehlmer, Elisabeth Scheikl-Pourkhalil, and Markus Teige -- Phosphatase activities analyzed by in vivo expressions / Alois Schweighofer, Zahra Ayatollahi, and Irute Meskiene -- Chromatin immunoprecipitation experiments to investigate in vivo binding of Arabidopsis transcription factors to target sequences / Benjamin Fode and Christiane Gatz -- Fluorescence-based electrophoretic mobility shift assay in the analysis of DNA-binding proteins / Sebastian Steiner and Thomas Pfannschmidt -- Analysis of plant regulatory DNA sequences by the yeast-one-hybrid assay / Dierk Wanke and Klaus Harter -- Analysis of plant regulatory DNA sequences by transient protoplast assays and computer aided sequence evaluation / Kenneth W. Berendzen, Klaus Harter, and Dierk Wanke -- RNA protein interaction mediating post-transcriptional regulation in the circadian system / Jan C. Schöning and Dorothee Staiger.
  • Transposable elements are DNA sequences with the capacity to move within a genome. Although their presence and impact has long been known, the recent genome-wide analysis of many eukaryotic genomes has uncovered their major role in genome dynamics and function. The present book explains how to recognize and study transposable elements, e.g. by using state-of-the-art strategies based on new-generation sequencing. Moreover, the impact of transposable elements on plant genome structure and function is reviewed in detail and illustrated in examples and case studies. The book is intended both for readers familiar with the field and for newcomers. With large-scale sequencing becoming increasingly available, more and more people will come across transposable element sequences in their data, and this volume will hopefully help to convince them that transposable elements are not just "junk" DNA, and may actually be the most interesting and fun part of their data!
  • Plant viral vectors 2014
    In this volume, the authors provide an excellent overview of how far the plant viral vector field has come. The discipline is no longer exclusively in the domain of academics-there is a small, but growing number of small biotechnology companies that exploit plant viruses as the platform for commercial innovation in crop improvement, industrial product manufacturing, and human and veterinary health care.
  • Plant-derived vaccines : technologies & applications / Franco M. Buonaguro -- Patents and molecular farming / Pascal M.W. Drake & Harry Thangaraj -- In planta production of recombinant and indigenous adjuvants / Antonio Granell, Asun Fernandez-del-Carmen & Diego Orzáez -- Rapid and high-yield production of immunotherapeutic plant-made antibodies / Cristina Capodicasa, Marcello Donini, Maria Elena Villani & Eugenio Benvenuto -- Vaccine peptide display on recombinant tobacco mosaic virus particles / Tatiana V. Komarova, Igor V. Petrunia & Yuri L. Dorokhov -- Plastid transformation as a tool for plant-based production of vaccines and therapeutic proteins / Paolo Lenzi, Nunzia Scotti, Pal Maliga & Teodoro Cardi -- Prophylactic and therapeutic HPV vaccines from plants / Edward P. Rybicki, Colomba Giorgi & Rosella Franconi -- Plant-derived anti-HIV-1 proteins / Nunzia Scotti, Luigi Buonaguro, Maria Lina Tornesello, Teodoro Cardi & Franco Maria Buonaguro -- Plant-based hepatitis B vaccines / Sergei N. Shchelkunov & Galina A. Shchelkunova -- Influenza vaccines : new perspectives from plants / Chiara Lico, Giampaolo Buriani, Floriana Capuano, Eugenio Benvenuto & Selene Baschieri -- Plant-made mucosal vaccines / Rurick K. Salyaev, Maria Manuela Rigano & Natalya I. Rekoslavskaya -- Current status of plant-made veterinary vaccines / Assunta Pelosi, Claire Penney, Huai-Yian Ling & Amanda M. Walmsley.
  • The use of protoplasts to study innate immune responses / Ping He, Libo Shan, and Jen Sheen -- Marker-exchange mutagenesis and complementation strategies for the gram-negative bacteria Xanthomonas oryzae pv. oryzae / Sang-Won Lee and Pamela C. Ronald -- Whole-genome analysis to identify type III-secreted effectors / Boris A. Vinatzer and Jean T. Greenberg -- In planta expression of oomycete and fungal genes / Thirumala-Devi Kanneganti, Edgar Huitema, and Sophien Kamoun -- Use of nipponbare bac clones for physical mapping of an R gene locus in rice / Jong-Seong Jeon and Pamela C. Ronald -- Agrobacterium-mediated transformation to create an insertion library in magnaporthe grisea / Sara L.Tucker and Marc J. Orbach -- Identification of components in disease-resistance signaling in arabidopsis by map-based cloning / Yuelin Zhang, Jane Glazebrook, and Xin Li -- Yeast two-hybrid approaches to dissecting the plant defense response / Mawsheng Chern, Todd Richter, and Pamela C. Ronald -- Use of rolling-circle amplification for large-scale yeast two-hybrid analyses / Xiaodong Ding, Yan Zhang, and Wen-Yuan Song -- Preparative denaturing isoelectric focusing for enhancing sensitivity of proteomic studies / Antonio Serna-Sanz, Greg Rairdan, and Scott C. Peck -- Use of massively parallel signature sequencing to study genes expressed during the plant defense response / Blake C. Meyers, Christian D. Haudenschild, and Kalyan Vemaraju -- Use of microarray analysis to dissect the plant defense response / Jane Glazebrook -- Use of robust long-serial analysis of gene expression to identify novel fungal and plant genes involved in host-pathogen interactions / Malali Gowda ... [et al.] -- Analysis of gene function in rice through virus-induced gene silencing / Xin Shun Ding, C. Srinivasa Rao, and Richard S. Nelson -- Use of RNA interference to dissect defense-signaling pathways in rice / Chuansheng Mei, Xiangjun Zhou, and Yinong Yang -- Virus-induced gene silencing in plant roots / Isgouhi Kaloshian -- Methods for engineering resistance to plant viruses / Mysore R. Sudarshana, Gourgopal Roy, and Bryce W. Falk -- Development of genetically engineered resistant papaya for papaya ringspot virus in a timely manner: a comprehensive and successful approach / Savarni Tripathi, Jon Suzuki, and Dennis. Gonsalves.
  • Plant vaccines: an immunological perspective / D.C. Hooper -- Display of peptides on the surface of tobacco mosaic virus particles / M.L. Smith ... [et al.] -- Chloroplast-derived vaccine antigens and biopharmaceuticals: expression, folding, assembly and functionality / S. Chebolu and H. Daniell -- Production of antibodies in plants: approaches and perspectives / K. Ko, R. Brodzik and Z. Steplewski -- Plant production of veterinary vaccines and therapeutics / R.W. Hammond and L.G. Nemchinov -- Plant-based oral vaccines: results of human trials / C.O. Tacket.
  • Print Material
  • With novel approaches to the application of new technologies via research based studies on stem cells, tissue engineering and new fields of reconstructive transplant (face, hand or larynx transplants), this book facilitates access to this latest knowledge which is not traditionally part of the plastic surgery curriculum. Plastic and Reconstructive Surgery ? Experimental Models and Research Designs presents pertinent introductions to different fields (stem cell, transplantation, nerve regeneration, tissue engineering) and experimental models which can be used as a tool to develop technologies of interest by various groups of surgeons. Plastic and Reconstructive Surgery ? Experimental Models and Research Designs benefits a range of surgeons, including plastic and reconstructive surgeons, microsurgeons, hand surgeons, orthopedic surgeons, neurosurgeons and transplant surgeons.
  • "Plastic Surgery Review meets the need for a high-yield, compact review book for the plastic surgery in-service, written board, and maintenance of certification examinations. Its 50 chapters are organized into four sections tested by the plastic surgery in-service examination: comprehensive plastic surgery craniomaxillofacial surgery breast and cosmetic surgery hand and lower extremity. An outline format with bullet points, tables, figures, mnemonics, and references facilitates review and memorization. Invited expert reviewers ensure the material is accurate and up-to-date"--Provided by publisher.
  • Plastic Surgery Secrets-the first Secrets Seriesʼ title in the PLUS format-offers an easy-to-read, information-at-your-fingertips approach to plastic and reconstructive surgery and hand surgery. Jeffrey Weinzweig has joined forces with world-renowned plastic surgeons Joseph McCarthy, Julia Terzis, Joseph Upton, Fernando Ortiz-Monasterio, and Luis Vasconez, and others to bring you the expert perspective you need to grasp the nuances of this specialty. This new edition features an additional color that highlights tables, legends, key terms, section and chapter titles, and web references. All this, along with the popular question-and answer approach and list of the "Top 100 Plastic Surgery Secrets," make it a perfect concise board review tool and a handy clinical reference. Maintains the popular and trusted Secrets Seriesʼ format, using questions and short answers for effective and enjoyable learning. Provides the most current overview and authoritative coverage of all topics thanks to contributions from an impressive list of over 300 experts in the field of plastic surgery and multiple related specialties.
  • Vol. 1: Section 1: Principles -- Section 2: Techniques -- Section 3: Basic Principles of Craniomaxillofacial Surgery -- Section 4: Craniofacial Surgery -- Section 5: Maxillofacial Surgery -- Section 6: Pediatric Plastic Surgery -- Section 7: Head and Neck Surgery -- Vol. 2: Section 8: Hand Surgery -- Section 9: Aesthetic Surgery.
  • Print Material
    v. 1. General principles -- v. 2. The head and neck, part 1 -- v. 3. The head and neck, part 2 -- v. 4. Pediatric plastic surgery -- v. 5. Tumors of the head, neck, and skin -- v. 6. Trunk and lower extremity -- v. 7. The hand and upper limb, part 1 -- v. 8. The hand and upper limb, part 2.
  • Plastic surgery. 3rd ed. v.1-6, 2013
    Fully updated to meet the demands of the 21st-century surgeon, this title provides you with all the most current knowledge and techniques across your entire field, allowing you to offer every patient the best possible outcome. Edited by Drs. Mathes and Hentz in its last edition, this six-volume plastic surgery reference now features new expert leadership, a new organization, new online features, and a vast collection of new information - delivering all the state-of-the-art know-how you need to overcome any challenge you may face. Renowned authorities provide evidence-based guidance to help you make the best clinical decisions, get the best results from each procedure, avoid complications, and exceed your patients' expectations.
  • Ch. 1 Introduction: Plasticity in the visual system: from genes to circuits -- Pt. I Retinal and thalamic plasticity -- Ch. 2 Synaptic plasticity and structural remodeling of rod and cone cells -- Ch. 3 Retinal remodeling: circuitry revisions triggered by photoreceptor degeneration -- Ch. 4 Retinal plasticity and interactive cellular remodeling in retinal detachment and reattachment -- Ch. 5 Experience-dependent rewiring of retinal circuitry: involvement of immediate early genes -- Ch. 6 Attentional activation of cortico-reticulo-thalamic pathways revealed by Fos imaging -- Pt. II Cortical plasticity -- Ch. 7 Neuromodulatory transmitters in sensory processing and plasticity in the primary visual cortex -- Ch. 8 Critical calcium-regulated biochemical and gene expression programs involved in experience-dependent plasticity -- Ch. 9 The molecular biology of sensory map plasticity in adult mammals -- Ch. 10 Plasticity of retinotopic maps in visual cortex of cats and monkeys after lesions of the retina or primary visual cortex -- Ch. 11 Intra-cortical inhibition in the regulation of receptive field properties and neural plasticity in the primary visual cortex -- Ch. 12 Plasticity in V1 induced by perceptual learning -- Ch. 13 Investigating higher order cognitive functions in the dorsal (magnocellular) stream of visual processing -- Ch. 14 Dopamine-dependent associative learning of workload-predicting cues in the temporal lobe of the monkey -- Pt. III Theoretical considerations -- Ch. 15 Linking visual development and learning to information processing: pre-attentive and attentive brain dynamics -- Ch. 16 Conclusion: a unified theoretical framework for plasticity in visual circuitry.
  • The polycarbonate products, adhesives, and composite resins used in dentistry may have the potential to release bisphenol-A (BPA). BPA is known to exert effects at very low doses and presents a risk to reproductive, neurological, behavioural, and metabolic development, however, the actual effects induced by dental materials have not been sufficiently covered and critically analyzed. Nevertheless, many practicing dentists will be confused by the occasionally contradictory and often misinterpreted evidence in the literature. This book therefore represents a timely and comprehensive review of our current knowledge of BPA release from dental polymers and the potential presence of endocrinological consequences. After a review of the history and evolution of the issue within the broader biomedical context, the estrogenicity of BPA is explained. The basic chemistry of the polymers used in dentistry is then presented in a simplified and clinically relevant manner. Key chapters in the book carefully evaluate the release of BPA from dental polymets and the estrogenicity of these materials. Currently available evidence on the potential estrogenic action of dental composites, sealants, and adhesives is presented, and the exaggerated conclusions of various methodological protocols are assessed. The entire dental community will find this book to be an invaluable aid to safe practice.
  • Platelet physiology / Martin Quinn -- Platelet integrins and signaling / Karlheinz Peter -- Platelet adhesion / Brian Savage and Zaverio M. Ruggeri -- Structure-function of the platelet cytoskeleton / Elaine L. Bearer -- Platelets and inflammation / Meinrad Gawaz -- Platelet signal-dependent protein synthesis / Stephan Lindemann ... [et al.] -- Phosphoproteomics of human platelets / Katrin Marcus and Helmut E. Meyer -- Platelet function studies / Dermot Cox -- Platelet function under flow / José A. López, Ian del Conde, and Jing-Fei Dong -- Pharmacodynamics of GPIIb-IIIa receptor blockade / Lisa K. Jennings and Melanie M. White -- Prostanoid generation in platelet function: assessment and clinical relevance / Bianca Rocca and Carlo Patrono -- Platelets and prothrombin / Michael Kalafatis ... [et al.] -- Markers of platelet activation and granule secretion / Alan D. Michelson and Mark I. Furman -- Genomic and proteomic analysis of platelets: clinical applications / Andrew Maree and James McRedmond -- Antiplatelet agents / Jacqueline Saw and David J. Moliterno -- Assessing platelet function in clinical trials / Neil Kleiman.
  • Platelets and megakaryocytes v.1-3, 2004, 2011
    Springer Protocols
    v. 2 Springer Protocols
    v.3 Springer Protocols
    v. 1. Functional assays -- v. 2. Perspectives and techniques.
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  • Ch.1. Theoretical Foundations -- Ch.2. Recognizing, Addressing, and Celebrating Diversity -- Ch.3. Logistics -- Ch.4. Data Collection: Intake and Mental Status -- Ch.5. Assessment -- Ch.6. Case Conceptualization -- Ch.7. Treatment Planning -- Ch.8. Interventions -- Ch.9. Session Activities -- Ch.10. Jennifer.
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  • Anatomy of the pleura -- Physiology of the pleural space-- Physiological effects of pneumothorax and pleural effusion-- Animal models in pleural investigation-- Cytokines and the pleura-- Radiographic examinations-- Clinical manifestations and useful tests-- Approach to the patient-- Transudative pleural effusions-- Pleural effusions related to metastatic malignancies-- Primary tumors of the pleura -- Parapneumonic effusions and empyema-- Tuberculous pleural effusions-- Pleural effusion secondary to fungal infections, actinomycosis, and nocardiosis -- Pleural effusion due to parasitic infection-- Pleural effusion due to acquired immunodeficiency syndrome, other viruses, mycoplasma pneumoniae, and rickettsiae-- Pleural effusion due to pulmonary embolization -- Pleural effusion secondary to diseases of the gastrointestinal tract -- Pleural effusion secondary to diseases of the heart-- Pleural disease in obstetrics and gynecology -- Pleural disease due to collagen vascular diseases -- Pleural effusion due to drug reactions -- Pleural effusion due to miscellaneous diseases-- Pneumothorax-- Hemothorax-- Chylothorax and pseudochylothorax -- Other pleural diseases -- Thoracentesis (diagnostic and therapeutic) and pleural biopsy -- Chest tubes -- Thoracoscopy.
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    Pathophysiology of signs and symptoms of coma -- Examination of the comatose patient -- Structural causes of stupor and coma -- Specific causes of structural coma -- Multifocal, diffuse, and metabolic brain diseases causing delirium, stupor, or coma -- Psychogenic unresponsiveness -- Approach to management of the unconscious patient -- Brain death -- Prognosis in coma and related disorders of consciousness, mechanisms underlying outcomes, and ethical considerations.
  • History of infusion therapy -- Minimizing risk and improving performance -- Nursing role and responsibilities -- Application of infusion nurses society standards of practice -- Anatomy and physiology applied to infusion therapy -- Laboratory tests and values -- Fluid and electrolyte balance -- Principles of parenteral fluid administration -- Complications and interventions -- Evidence-based infusion practice -- Infusion equipment and safety -- Peripheral infusion therapy techniques -- Short peripheral access -- Central venous access -- Alternate access -- Parenteral nutrition -- Transfusion therapy -- Pharmacology applied to infusion therapy -- Antineoplastic therapy -- Pain management -- Pediatric intravenous therapy -- Infusion therapy in an older adult patient -- Infusion therapy in alternate clinical settings: cost factors and treatment modalities -- The future of infusion nursing.
  • Moral casuistry, medical research, and innovation, and rabbinical decision-making / Mark J. Cherry and Ana Smith Iltis -- SECTION I PLURALISTIC MORAL CASUISTRY -- Notes toward a pluralistic professional medical ethics / Laurence B. Mccullough -- Ethics and a deep moral ambiguity / Kevin WM. Wildes -- Moral judgement and the ideal intuitor : dealing with moral confusion and moral disagreement / Janet Malek -- Casuistry naturalized / Maureen Kelley -- SECTION II JEWISH MEDICAL ETHICS -- Intuitionism, divine commands, and natural law / Andrew Lustig -- In case : Contingency and particularity in bioethics : Discursive method and clinical midrash brief notes on a lesson from my teacher Baruch Brody / Laurie Zoloth -- The Euthyphyro's dilemma reconsidered : a variation on a theme from Brody on halakhic method / H. Tristram Englehardt, Jr. -- SECTION III BIOMEDICAL PUBLIC POLICY -- The Good (philosophy), the bad (public policy) and the ugliness of blaming families for ineffectual treatments / Robert M. Arnold -- Is withholding artificial nutrition and hydration from PVS Patients active euthanasia? / Loretta M. Kopelman -- SECTION IV CRITICAL APPLICATION AND ANALYSIS -- The virtue of integrity in Baruch Brody's moral framework / J. CLint Parker -- Paradigms, practices and politics : ethics and the language of the human embryo transfer/donation/rescue/adopition / Sarah-Vaughan Brakman -- Brody on Passive and Active Euthanasia / F. M. Kamm -- SECTION V RESPONSE TO FRIENDS AND CRITICISMS -- Comments on the Essays / Baruch A. Brody.
  • This addition to the Springer Brief in Stem Cells series focuses on aspects related to the specific mechanisms that ensure and control pluripotency and cell commitment in domestic animal species. This topic is generating rapidly-increasing interest due to the great potential for domestic animal species to be used as intermediate biomedical models, between the mouse and the human. The Brief addresses why we need large animal models for regenerative medicine. It also describes early embryo development with a careful and specific analysis of the regulatory mechanisms driving cleavage, polarization and genome activation in domestic species. How pluripotency is compartmentalized in domestic species as well as the different aspects that make the derivation of stem cells in domestic species very difficult are also addressed.
  • Pneumococcal conjugate vaccines / Ger T. Rijkers -- Pneumococcal conjugate vaccines overview / Michael E. Pichichero -- Pneumococcal conjugate vaccines in children / Ingeborg S. Aaberge -- Pneumococcal vaccination in elderly / Ger T. Rijkers -- Pneumococcal conjugate vaccine in immunocompromised individuals / Marta C. Nunes & Shabir A. Madhi -- Pneumococcal conjugate vaccines in developing countries / Ener Cagri Dinleyici -- Current and future guidelines for pneumococcal conjugate vaccination / Elske van Gils, Ger Rijkers & Elisabeth Sanders -- Antibody response to pneumococcal polysaccharide vaccination in patients treated with biologicals / Minke Rab & Ger T. Rijkers -- Index.
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    The advent of type-specific antipneumococcal serotherapy -- A "specific" specific and the turbid age of applied immunology -- Fundamental tensions: clinical "proof" and clinical resistance -- The Massachusetts experiment and New (York) tensions -- The new standard, the new deal, and the pneumonia control programs -- Histology of a revolution -- A "modern" revolution: the limits and uses of controlled clinical trials -- The dismantling of pneumonia as a public health concern.
  • PNF (Proprioceptive Neuromuscular Facilitation) is a concept to therapeutic exercise which therapists all over the world have found effective for treating patients with a wide range of diagnoses. The approach presented in this richly illustrated guide is based on the concepts set out by Dr. Herman Kabat and taught by Margaret Knott. The fully revised fourth edition demonstrates how the principles of the International Classification of Functioning, Disability and Health (ICF) and aspects of motor learning and motor control (from hands-on to hands-off management) are applied in modern PNF evaluation and treatment. A new fresh fully-coloured design and layout highlights the clearly structured way in which philosophy, basic procedures and treatment patterns of PNF are based. New for this edition -Fully revised introductory chapter on the PNF basics, now including discussion and demonstration of ICF and Motor Learning aspects in detailed case study. -Throughout chapters, new additional case studies that help visualize the application of PNF applications in promoting the patients everyday-life motor skills on activity and participation levels.
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  • History / Marnae C. Ergil -- Fundamental theory of Chinese medicine / Kevin V. Ergil -- Diagnosis in Chinese medicine / Kevin V. Ergil -- Acupuncture / Marnae C. Ergil -- Tui na / Michael McCarthy and Kevin V. Ergil -- Traditional Chinese pharmacotherapy / Simon Becker -- Chinese dietetic / Mary Garvey -- Qi gong / Anne Reinard and Yves Réquéna -- Tai ji quan / Douglas Wile -- Acupuncture research : an overview / Stephen Birch.
  • Includes skull and oral tumor images
  • Examination -- Imaging and patient position -- Parasternal long-axis view -- Parasternal short-axis view -- Apical windows -- Suprasternal window -- Subcostal window -- M-mode and Doppler echocardiography -- M-mode -- Doppler -- Cardiac abnormalities -- Valvular heart disease -- Coronary heart disease -- Cardiomyopathies -- Prosthetic valves -- Carditis -- Septal defects -- Hypertensive heart diseases -- Intracardiac masses.
  • At a glance -- General anatomy -- Bones -- Sutures, joints, ligaments -- Muscles -- Tendon sheaths and bursae -- Alimentary system -- Respiratory system -- Urogenital system -- Abdominopelvic cavity -- Endocrine glands -- Heart -- Arteries -- Veins -- Lymphoid system -- Meninges -- Spinal cord -- Brain -- Cranial nerves -- Spinal nerves -- Autonomic nervous system -- Sense organs -- Skin and its appendages.
  • Anatomy / M. Grueb -- Optical system and physiology / M. Grueb -- Lids / M. Grueb -- Lacrimal apparatus / J. Mielke -- Orbit / J.M. Rohrbach, D. Holland -- Strabismus / H.-S. Walter -- Conjunctiva / J. M. Rohrbach -- Cornea / J. Mielke -- Sclera / T. Schlote -- Choroid and iris / T. Schlote -- Lens / J.M. Rohrbach -- Glaucoma / M. Grueb -- Retina and vitreous body / F. Gelisken -- Macula / U. Schneider -- Optic nerve and optic pathway / P. Weckerle -- Drug-induced ocular side-effects / T. Schlote -- Eye diseases in developing countries / J. Mielke.
  • White lesions -- Red lesions -- Black and brown lesions -- Vesiculobullous lesions -- Ulcerative lesions -- Papillary lesions -- Gingival enlargement -- Soft-tissue tumors -- Soft-tissue cysts -- Bone swellings -- Neck swellings -- Lip lesions.
  • Skull -- Spine -- Upper extremities -- Lower extremities -- Routine radiographs -- Spot images -- Tomography -- Gastrointestinal system -- Intravenous contrast studies -- Arthrography -- Arteriography -- Venograpy -- Special studies.
  • v. 2 Thieme
    "This comprehensive, easy-to-consult pocket atlas is renowned for its superb illustrations and ability to depict sectional anatomy in every plane. Together with its two companion volumes, it provides a highly specialized navigational tool for all clinicians who need to master radiologic anatomy and accurately interpret CT and MR images. Special features of Pocket Atlas of Sectional Anatomy: - Didactic organization in two-page units, with high-quality radiologic images on one side and brilliant, full-color diagrams on the other - Hundreds of high-resolution CT and MR images, many made with the latest generation of scanners (e.g., 3T MRI, 64-slice CT) - Consistent color coding, making it easy to identify similar structures across several slices - Concise, easy-to-read labeling of all figures. Updates for the 4th edition of Volume I: - New cranial CT imaging sequences of the axial and coronal temporal bone - Expanded MR section, with all new 3T MR images of the temporal lobe and hippocampus, basilar artery, cranial nerves, cavernous sinus, and more - New arterial MR angiography sequences of the neck and additional larynx images Compact, easy-to-use, highly visual, and designed for quick recall, this book is ideal for use in both the clinical and study settings. Volume I: Head and Neck Volume II: Thorax, Heart, Abdomen, and Pelvis, ISBN 978-3-13-125604-1 Volume III: Spine, Extremities, Joints, ISBN 978-3-13-143171-4 Torsten B. Moeller, MD, and Emil Reif, MD, Department of Radiology, Marienhaus Klinikum Saarlouis-Dillingen, Dillingen/Saarlouis, Germany"--Provided by publisher.
  • Pocket atlas of spine surgery 2012
    Thieme eNeurosurgery
    "This atlas will serve as a valuable resource not only for orthopedic surgeons, neurosurgeons, and surgical trainees such as residents and fellows, but also for physician assistants, nursing staff personnel, and anyone else involved in the operative care of patients undergoing spinal surgery"--Provided by publisher.
  • In this fully up-to-date Second Edition, experts in Chinese medicine explain how traditional Chinese tongue diagnosis can be used in daily practice to complement conventional Western methods. The guide begins with a brief introduction to the history, anatomy, physiology, and methodology of tongue diagnosis followed by basic techniques and systematic procedures for identifying the manifold individual characteristics of the tongue's shape and its many modifications. Full-color photographs of tongues then demonstrate a variety of clinical scenarios to help readers develop a holistic approach to diagnosis.
  • Section 1. Approach to the patient with renal disease -- section 2. Disturbances in control of body fluid volume and composition -- section 3. Epidemiology of renal disease -- section 4. Pathogenesis of renal disease -- section 5. Genetic basis of kidney disease -- section 6. Hypertension and the kidney -- section 7. The consequences of renal failure -- section 8. Conservation and pharmacologic management of kidney disease -- section 9. Invasive therapy of renal failure -- section 10. Renal transplantation.
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  • Pocket guide to diagnostic tests 2012 (6th ed.)
  • This book provides a concise, patient-directed approach to stone prevention. It defines who to evaluate and when to treat, and provides empiric guidelines for all stone formers. Specific treatment guidelines are also included, based on the kidney stone composition and the underlying metabolic abnormalities demonstrated by 24-hour urine stone risk profile. Written by experts in the field, Pocket Guide to Kidney Stone Prevention: Dietary and Medical Therapy serves as a valuable resource for a broad base of clinicians in primary and specialty care.
  • Neck pain and shooting arm pain -- Shoulder pain -- Elbow pain -- Wrist and hand pain -- Low back pain, hip pain, and shooting leg pain -- Knee pain -- Ankle pain -- Foot pain.
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    Acid-base and electrolyte disorders / Mildred Lam -- Cardiovascular system / Stephen N. Adler -- Endocrine/metabolic system / Thomas A. Murphy -- Gastrointestinal and hepatic systems / Wendell K. Clarkston, Patricia Sanchez, and Bruce R. Bacon -- Genitourinary system / Mildred Lam -- Hematologic system / Kyung-Whan Min -- Infectious disease / Debra Adler-Klein -- Integument / Dianne B. Gasbarra -- Musculoskeletal system / Dianne B. Gasbarra -- Nervous system / Stephen N. Adler -- Respiratory system / Dianne B. Gasbarra -- Human immunodeficiency virus infection / Debra Adler-Klein.
  • Pre-Operative Evaluation of the Thoracic Patient -- Operative and Post-Operative Considerations -- Lung and Airway Disorders -- Pleural Disorders -- Mediastinal Disorders -- Chest Wall Disorders -- Chest Trauma -- Benign Esophageal Disorders -- Esophageal Cancer.
  • History and physical examination -- Laboratory assessment -- Arthrocentesis and synovial fluid analysis -- Imaging techniques -- Monarticular joint disease -- Polyarticular joint disease -- Regional rheumatic pain syndromes -- Fibromyalgia and diffuse pain syndromes -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Psoriatic arthritis -- Ankylosing spondylitis -- Reactive and enteropathic arthritis -- Osteoarthritis -- Calcium pyrophosphate dehydrate, hydroxyapatite, and miscellaneous crystals -- Infectious disorders -- Systemic lupus erythematosus -- Antiphospholipid syndrome -- Systemic sclerosis -- Idiopathic inflammatory myopathies -- Metabolic myopathies -- Sjogren's syndrome -- Vasculitides -- Behcet's syndrome -- Adult Still's disease -- Autoinflammatory disorders/periodic syndromes -- Less common arthropathies -- Complex regional pain syndrome -- Osteonecrosis -- Paget's disease -- Osteoporosis -- Therapeutic injection -- Nonsteroidal anti-inflammatory drugs -- Glucocorticoids -- Operative treatment -- Complementary and alternative therapies.
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  • This Pocket Reference offer a multifaceted guide on various aspects of Alzheimerℓ́ℓs disease. This thorough review discusses the challenges of diagnosis, different stages of the disease, testing, and current treatment methods, including pharmacological and nonpharmacological management of cognitive decline and symptoms due to Alzheimerℓ́ℓs disease. The book also has specific chapters on care issues for patients with Alzheimerℓ́ℓs disease, which describes what clinician's and caregivers should expect and how to manage the disease at its various stages. Additionally, the book provides helpful guides, tables, and tips for clinicians and caregivers to help care for the patient and the caregiver themselves.
  • Pocket Reference to Renal Anemia, Second edition, provides a comprehensive overview of anemia in patients with renal disease, including the definition and causes of renal anemia, current management approaches, and the latest clinical practice guidelines. Key learning points are highlighted throughout the book and also listed at the end of the book for a quick reference. The book is useful for general physicians, fellows, and other healthcare professionals wishing to learn more about renal anemia.
  • Medical management -- Imaging of the spine / Donna D. Ohnmeiss, Hector Soriano-Baron, Eduardo Martinez-del-Campo, Nicholas Theodore, Camden Whitaker -- Head and spine trauma / Camden Whitaker, Rob D. Dickerman, Ryan Stuckey -- Cervical degenerative disc disease -- Rheumatoid arthritis of the cervical spine -- Spinal deformities in pediatric, adolescent, and adult patients / Camden Whitaker, Ryan Stuckey -- Lumbar radiculopathy -- Compression fractures and osteoporosis / Camden Whitaker, Ryan Stuckey -- Low back pain / Camden Whitaker, Ryan Stuckey -- Spinal stenosis -- Diagnosis and treatment of sacroiliac joint pain (sacrogenic pain) / Ralph F. Rashbaum -- Spinal cord tumors / Rob D. Dickerman.
  • Podocytopathy 2014
    Cell biology of the podocyte / Jefferson, J.A.; Shankland, S.J. -- Cell cycle and podocyte injury / Hagmann, H.H.; Shankland, S.J.; Brinkkoetter, P.T. -- The podocyte cytoskeleton : key to a functioning glomerulus in health and disease / Faul, C. -- Crosstalk between podocytes and tubular epithelial cells / Leung, J.C.K.; Kar, N.L.; Tang, S.C.W. -- Role of mitochondria in podocyte injury / Yuan, Y.; Huang, S.; Zhang, A. -- Autophagy in podocytes / Zhang, L.; Livingston, M.J.; Chen, J.-K.; Dong, Z. -- PPAR- : signaling in podocyte injury / Wang, W.; Yang, T. -- Podocyte injury in FSGS / Ding, W.Y.; Saleem, M.A. -- Circulating soluble urokinase receptor and focal segmental glomerulosclerosis / Wei, C.; Reiser, J. -- Anti-phospholipase A2 receptor-1 autoantibodies and membranous nephropathy / Beck, L.H. -- Anti-neutral endopeptidase antibodies, autoantibodies, anti-bovine serum albumin antibodies and membranous nephropathy / Ronco, P.; Debiec, H. -- Podocytopathy in diabetes : a metabolic disorder / Merscher, S.; Lenz, O.; Fornoni, A. -- Obesity-related glomerulopathy and podocyte injury / Camici, M. -- Podocyte injury in HIV-associated nephropathy / Mallipattu, S.K.; He, J.C. -- Retinoic acid : a potential pharmacologic approach in the treatment of podocytopathy / Sharma, S.; Mallipattu, S.K.; Zhong, Y.; He, J.C. -- Immunomodulatory drugs and the podocyte / Mathieson, P.W. -- Triptolide protects podocytes from injury / Qin, W.; Liu, Z.-H. -- Fly : a model to study the podocyte / Na, J.; Cagan, R.L. -- Zebrafish models of podocytopathies / Boucher, R.C.; Zhou, W. -- The role of micrornas in podocytes / Shi, S.; Liu, Z.-H. -- An integrative biology approach to study podocyte function / Ju, W.; Hodgin, J.; Jiang, S.; Kretzler, M.
  • The Poincaré plot (named after Henri Poincaré) is a popular two-dimensional visualization tool for dynamic systems due to its intuitive display of the dynamic properties of a system from a time series. This book presents the basis of Poincaré plot and focus especially on traditional and new methods for analysing the geometry, temporal and spatial dynamics disclosed by the Poincaré plot to evaluate heart rate variability (HRV). Mathematical descriptors of Poincaré plot have been developed to quantify the autonomic nervous system activity (sympathetic and parasympathetic modulation of heart rate). Poincaré plot analysis has also been used in various clinical diagnostic settings like diabetes, chronic heart failure, chronic renal failure and sleep apnea syndrome. The primary aims of quantification of the Poincaré plots are to discriminate healthy physiological systems from pathological conditions and to classify the stage of a disease. The HRV analysis by Poincaré plot has opened up ample opportunities for important clinical and research applications. Therefore, the present book can be used either for self-study, as a supplement to courses in linear and nonlinear systems, or as a modern monograph by researchers in this field of HRV analysis.
  • Point of care ultrasound 2015
    With portable, hand-carried ultrasound devices being more frequently implemented in medicine today, Point-of-Care Ultrasound will be a welcome resource for any physician or health care practitioner looking to further their knowledge and skills in point-of-care ultrasound. This comprehensive, portable handbook offers an easy-access format that combines electronic content and peer-reviewed videos to provide comprehensive, non-specialty-specific guidance on this ever-evolving technology. Access all the facts with focused chapters covering a diverse range of topics, as well as case-based examples that include ultrasound scans and videos.Understand the pearls and pitfalls of point-of-care ultrasound through contributions from experts at more than 30 institutions. View techniques more clearly than ever before. Illustrations and photos include transducer position, cross-sectional anatomy, ultrasound cross sections, and ultrasound images.Watch more than 200 ultrasound videos from real-life patients that demonstrate key findings. Available at Expert Consult, these videos are complemented by anatomical illustrations and text descriptions to maximize learning.
  • Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
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  • Introduction: Understanding the Management of Police Services -- Historical Perspective: British Policing and the Democratic Ideal -- Part 2- Context of Policing -- Quo Vadis: A New Direction for Police Leadership through Community Engagement? -- Initial police training and the development of police occupational culture -- Community Engagement, Democracy and Public Policy: a Practitioner Perspective -- Dealing with Diversity in Police Services -- Risk Management in Policing -- Perspectives on the Essence of Policing -- Part 3- Current debates in Policing -- Enhancing Police Accountability in England and Wales: What differences are Police and Crime Commissioners making? -- Police management and workforce reform in a period of austerity -- Personal Resilience and Policing -- Part 4- Looking to the Future -- Some Futures for the Police: Scenarios and Science -- The Future of Policing in the United Kingdom -- A Crisis or a Perfect Storm: the trouble with Public Policing?.-International Perspectives in Policing: Challenges for 2020.-International perspectives in policing: Challenges for 2020.
  • Enzymes in poly(ADP-ribose) metabolism / Ralph G. Meyer ... [et al.] -- PARP-2: structure-function relationship / Valørie Schreiber ... [et al.] -- Targeting the poly(ADP-ribose) glycohydrolase (PARG) gene in mammals / Ulrich Cortes and Zhao-Qi Wang -- DNA damage signaling through poly(ADP-ribose) / Maria Malanga and Felix R. Althaus -- Roles of poly(ADP-ribose) metabolism in the regulation of centrosome duplication and in the maintenance of neuronal integrity / Masanao Miwa ... [et al.] -- Functional interactions of PARP-1 with p53 / Rafael Alvarez-Gonzalez ... [et al.] -- Dynamic interaction between PARP-1, PCNA and p21waf1/cip1 / Ennio Prosperi and A. Ivana Scovassi -- Parp-1 as novel coactivator of NF-kB in inflammatory disorders / Paul O. Hassa and Michael O. Hottiger -- PARP and epigenetic regulation / Paola Caiafa -- PARP and the release of apoptosis-inducing factor from mitochondria / Suk Jin Hong, Ted M. Dawson and Valina L. Dawson -- Genome degradation by DNAS1L3 endonuclease: a key PARP-1-regulated event in apoptosis / A. Hamid Boulares, Alexander G. Yakovlev and Mark E. Smulson -- NAD-metabolism and regulatory functions / Mathias Ziegler -- PARP-1 and the shape of cell death / Laszlø Virøg -- Poly(ADP-ribose) polymerase (PARP) and excitotoxicity / Domenico E. Pellegrini-Giampietro, Alberto Chiarugi and Flavio Moroni -- Poly(ADP-ribose) polymerase and ischemia-reperfusion injury / Prabal K. Chatterjee and Christoph Thiemermann -- Role of poly(ADP-ribose) polymerase activation in the pathogenesis of inflammation and circulatory shock / Csaba Szabø -- Role of poly-ADP-ribosylation in cancer development / Mitsuko Masutani ... [et al.] -- PARP inhibitors and cancer therapy / Nicola J. Curtin -- Poly(ADP-ribosyl)ation and aging / Sascha Beneke and Alexander Bürkle.
  • Polyamine structure and synthetic analogs / Patrick M. Woster -- Acute increases in intracellular putrescine lead to the increase in steady-state levels of c-fos, c-jun, RING3, and Id-1 mRNAs / Allan A. Ancheta, Leo Hawel III, and Craig V. Byus -- Polyamine-dependent early cellular signals and cell proliferation / Stina M. Oredsson -- Cellular signals mediating growth arrest after polyamine depletion / Jian-Ying Wang -- Role of polyamines in the regulation of chromatin acetylation / Cheryl A. Hobbs and Susan K. Gilmour -- Role of polyamines in regulation of sequence-specific DNA binding activity / Sripriya Venkiteswaran, Thresia Thomas, and T.J. Thomas -- Polyamine metabolism and the hypertrophic heart / Lisa M. Shantz and Emanuele Giordano -- Influence of polyamines on breast cancer biology / Andrea Manni -- Polyamines in regulation of prostatic cell growth / Raymond G. Schipper ... [et al.] -- Polyamines and cytoskeletal regulation during intestinal epithelial restitution / Ramesh M. Ray and Leonard R. Johnson -- Regulation of Kv channel activity and intercellular junctions by polyamines in intestinal epithelial cells / Jaladanki N. Rao and Jian-Ying Wang -- Polyamine block of Kir channels: toward a molecular picture / Harley T. Kurata and Colin G. Nichols -- Regulation of ornithine decarboxylase expression / Lo Persson -- Evidence for a multistep model for eukaryotic polyamine transport / Richard Poulin ... [et al.] -- Bacterial and eukaryotic transport systems / Kazuei Igarashi and Keiko Kashiwagi -- Regulation of S-adenosylmethionine decarboxylase / Colin Hanfrey -- Genetic engineering of polyamine catabolism in transgenic mice and rats / Juhani Jänne ... [et al.]. Polyamines in kidney biology / Joseph Satriano -- Polyamines in pulmonary vascular biology / Jack W. Olson and Mark N. Gillespie -- Recent advances in the understanding of mammalian polyamine catabolism: the regulation and potential role of polyamine catabolism in drug response and disease processes / Robert A. Casero, Jr. ... [et al.] -- Cellular signaling and polyamines in the control of apoptosis in intestinal epithelial cells / Leonard R. Johnson and Ramesh M. Ray -- The role of ornithine decarboxylase in Myc-induced tumorigenesis / Jonas A. Nilsson and John L. Cleveland -- Protective effect of polyamines on NSAID-induced injury and apoptosis / Heather M. Wallace and Alun Hughes -- Role of polyamines in the control of the immune response in the brain / Denis Soulet and Serge Rivest -- Implication of polyamines in apoptosis of immunoresponse cells / Rupesh Chaturvedi and Keith T. Wilson -- Polyamines and cancer / Ajit K. Verma -- Polyamine pools and cancer prevention / Eugene W. Gerner and David E. Stringer --
  • Polyamines
  • Polyamines-- methods and protocols 2011
    Springer Protocols
    [Publisher-supplied data] Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
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  • Polycystic ovary syndrome : definitions, phenotypes and diagnostic approach / S. Livadas, E. Diamanti-Kandarakis -- Pathophysiology of polycystic ovary syndrome : the role of hyperandrogenism / S. Catteau-Jonard, D. Dewailly -- Genetics of polycystic ovary syndrome / T.M. Barber, S. Franks -- Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome / E. Carmina -- Dyslipidemia and oxidative stress in PCOs / D. Macut, J. Bjekić-Macut, A. Savić-Radojević -- Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome / K. Bajuk Studen, M. Jensterle Sever, M. Pfeifer -- Insulin sensitizers in polycystic ovary syndrome / R. Pasquali, A. Gambineri -- Hirsutism : from diagnosis to use of antiandrogens / K. Unluhizarci, Z. Karaca, F. Kelestimur -- Combined oral contraceptives in polycystic ovary syndrome : indications and cautions / G. Bozdag, B.O. Yildiz -- Infertility treatment in polycystic ovary syndrome : lifestyle interventions, medications and surgery / D. Panidis ... [et. al.] -- Endocrinopathies and other disorders inducing a polycystic ovary syndome phenotype / K.I. Alexandraki, G.A. Kaltsas -- Non-classic adrenal hyperplasia due to the deficiency of 21-hydroxylase and its relation to polycystic ovarian syndrome / D. Pignatelli.
  • Presenting an overview of the current understanding of the pathophysiology of PCOS and a paradigm for the clinical evaluation and management of the disorder, Polycystic Ovary Syndrome is written in an easy to digest, concise format that, with bulleted key points introducing each chapter, is suitable for the trainee and the busy clinician. The breadth and depth of coverage of today's queries and controversies will be of particular interest to the specialist and researcher. An international group of leading experts addresses the varied etiologies of PCOS, comprehensively covering the contemporary treatment approaches and long-term implications of PCOS, a common yet poorly understood disorder. Chapters on treatment will be of particular relevance to the clinician and the trainee as they cover conventional therapies, lifestyle, and diet, as well as address emerging strategies such as the use of statins and surgery in PCOS management. Spanning the breadth of clinical presentations and morbidities related to the diagnosis of PCOS, Polycystic Ovary Syndrome is an exceptional resource for primary care providers, gynecologists, reproductive endocrinologists, and others involved in the care of these patients, and provides the essential tools to aid clinicians in initiating a timely diagnostic workup and appropriate interventions to address both the immediate and long-term sequelae related to PCOS.
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  • Introduction / Joseph Seckbach, Aharon Oren, and Helga Stan-Lotter -- Foreword / Richard W. Castenholz -- Preface / Koki Horikoshi -- Editors' biographies -- List of authors and their addresses -- Polyextremophiles and the constraints for terrestrial habitability / M.C. Capece et al. -- Life on the edge and astrobiology : who is who in the polyextremophiles world? / J. Seckbach -- The dynamic genomes of acidophiles / F.J. López de Saro et al. -- Two centuries of microbiological research in the Wadi Natrun, Egypt : a model system for the study of the ecology, physiology, and taxonomy of haloalkaliphilic microorganisms / A. Oren -- Adaptation in haloalkaliphiles and natronophilic bacteria / H.L. Banciu and D.Y. Sorokin -- A random biogeochemical walk into three soda lakes of the western USA : with an introduction to a few of their microbial denizens / R.S. Oremland -- Halophilic, acidophilic, and haloacidophilic prokaryotes / H. Minegishi -- Life in magnesium- and calcium-rich hypersaline environments : salt stress by chaotropic ions / A. Oren -- Survival strategies of halophilic oligotrophic and desiccation resistant prokaryotes / H. Stan-Lotter and S. Fendrihan -- Radiation resistance in extremophiles : fending off multiple attacks / K.M. Webb and J. DiRuggiero -- Thermoalkaliphilic microbes / V. Kumar and T. Satyanarayana -- Acido- and thermophilic microorganisms : their features, and the identification of novel enzymes or pathways / Y. Kawarabayasi -- Microbial diversity in acidic high-temperature steam vents / R.L. Weiss Bizzoco and S.T. Kelley -- Left out in the cold : life in cryoenvironments / J. Goordial et al. -- Microbial diversity and enzymes in ikaite columns : a cold and alkaline environment in Greenland / J.K. Vester et al. -- Microbial communities thriving in various ice ecosystems / B. Sattler et al. -- Snow algae : adaptation strategies to survive on snow and ice / T. Leya -- Adaptation of Antarctic freshwater green algae to extreme environments / H. Hu -- Deep subsurface oil reservoirs as poly-extreme habitats for microbial life. A current review / A. Wentzel et al. -- Expanding limits for life to a new dimension : microbial growth at hypergravity / S. Deguchi and K. Horikoshi -- Microbial eukaryotes in marine oxygen minimum zones / W.D. Orsi and V.P. Edgcomb -- Deep hypersaline anoxic basins as model systems for environmental selection of microbial plankton / A. Stock et al. -- Microbial eukaryotes in hypersaline anoxic deep-sea basins / V.P. Edgcomb and W.D. Orsi -- Life at high salt and low oxygen : how do the Halobacteriaceae cope with low oxygen concentrations in their environment? / A. Oren -- Niches and adaptations of polyextremotolerant black fungi / M. Grube et al. -- Polyextremophilic photoautotrophic eukaryotic algae / W. Reisser -- Extremophilic magnetotactic bacteria / C.T. Lefèvre and D.A. Bazylinski -- Tardigrades : an example of multicellular extremophiles / D. Schulze-Makuch and J. Seckbach -- Polyextremophiles : summary and conclusions / J. Chela-Flores.
  • Part I. Polymers as Biomaterials -- 1. Polysaccharides as Biomaterials / Severian Dumitriu -- 2. Biomimetics / Weiyuan John Kao -- 3. Silicones for Pharmaceutical and Biomedical Applications / Haissam S. El-Zaim and John P. Heggers -- 4. Biodegradable Polymers as Drug Carrier Systems / Abraham J. Domb, Neeraj Kumar, Tzviel Sheskin, Alfonso Bentolila, Joram Slager, and Doron Teomim -- 5. Biodegradable Biomaterials Having Nitric Oxide Biological Activity / C.C. Chu -- 6. Hydrogels for Biomedical and Pharmaceutical Applications / Akio Kishida and Yoshito Ikada -- 7. Mucoadhesive Polymers / Andreas Bernkop-Schnürch -- 8. Polymers for Tissue Engineering Scaffolds / Howard W.T. Matthew -- 9. Chitosan: Structure-Properties Relationship and Biomedical Applications / Alain Domard and Monique Domard -- 10. Chitosan-Based Delivery Systems: Physicochemical Properties and Pharmaceutical Applications / Radi Hejazi and Monsoor Amiji -- 11. Immobilization of Active Biopolymers from Cold Plasma-Functionalized Surfaces for the Creation of Molecular Recognition and Molecular Manufacturing Systems / Ferencz Denes and Sorin Manolache -- 12. Advances in Designed Multivalent Bioconjugates with Dendritic Structure / Bogdan Comanita -- 13. Biocompatibility of Elastomers / D.J. Chauvel-Lebret, P. Auroy, and M. Bonnaure-Mallet -- 14. Control of Cell-Biomaterial Interactions / Danielle C. Giliberti, Kyle K. White, and Kay C Dee -- Part II. Medical and Pharmaceutical Applications of Polymers -- 15. Polymeric Systems for Ophthalmic Drug Delivery / O. Felt, S. Einmahl, P. Furrer, V. Baeyens, and R. Gurny -- 16. Dental and Maxillofacial Surgery Applications of Polymers ? A. Bascones, J. M. Vega, N. Olmo, J. Turnay, J.G. Gavilanes, and M.A. Lizarbe -- 17. Biomaterials in Bum and Wound Dressings / Robert L. Sheridan, Jeffrey R. Morgan, and Rashid Mohammad -- 18. Dermocosmetic Applications of Polymeric Biomaterials / P. Corvi Mora and P.G. Baraldi -- 19. Textile-Based Biomaterials for Surgical Applications / C.C. Chu -- 20. Bioabsorbable Polymers for Medical Applications with an Emphasis on Orthopedic Surgery / Pentti U. Rokkanen -- 21. Polymers for Artificial Joints / Naohide Tomita, Kazuya Nagata, and Hiroshi Fujita -- 22. Polymeric Occluders in Tilting Disc Heart Valve Prostheses / G.S. Bhuvaneshwar, A.V. Ramani, and K.B. Chandran -- 23. Blood-Contacting Polymers / T. Avramoglou, J. Jozefonvicz, and M. Jozefowicz -- 24. Surface Modification of Dacron Vascular Grafts: Incorporation of Antithrombin and Mitogenic Properties / Matthew D. Phaneuf Martin J. Bide, William C. Quist, and Frank W. LoGerfo -- 25. Antithrombin-Heparin Complexes / Leslie R. Berry, Maureen Andrew, and Anthony K.C. Chan -- 26. Adhesives for Medical Applications / lain Webster and Peter J. West -- 27. Glucose-Sensitive Hydrogel Membranes / Jin Ho Lee, Jung Ju Kim, and Kinam Park -- 28. Polymeric Micro- and Nanoparticles as Drug Carriers / G. Barratt, G. Couarraze, P. Couvreur, C. Dubernet, E. Fattal, R. Gref, D. Labarre, P. Legrand, G. Ponchel, and C. Vauthier -- 29. Liposomes in Drug Delivery / Yuan-Peng Zhang, Boris Ceh, and Danilo D. Lasic -- 30. Liposomes for Cancer Therapy Applications / Lawrence D. Mayer, Rajesh Krishna, and Marcel B. Bally -- 31. Systemic Cancer Therapy Using Polymer-Based Prodrugs and Progenes / Leonard W. Seymour -- 32. Anticancer Drug Conjugates with Macromolecular Carriers / F. Kratz, A. Warnecke, K. Riebeseel, and P.C.A. Rodrigues -- 33. Enzyme-Prodrug Therapies of Cancer / Richard J. Knox, Roger G. Melton, and Ronit Satchi -- 34. New Lipid/DNA Complexes for Gene Delivery / Kenneth W. Liang and Leaf Huang -- 35. Gene Delivery by Cationic Liposome-DNA Complexes / Nejat Düzgüneş, Sérgio Simões, Pedro Pires, and Maria C. Pedroso de Lima -- 36. Biological Stimulus-Responsive Hydrogels / Takashi Miyata and Tadashi Uragami -- 37. Biocompatible Polymers in Liver-Targeted Gene Delivery Systems / Edwin C. Ouyang, George Y. Wu, and Catherine H. Wu -- 38. Bioartificial Pancreas / Riccardo Calafiore -- 39. Transdermal Delivery of Drugs / B.B. Michniak and A. El-Kattan -- 40. Drug Delivery via Mucosal Routes / Nimit Worakul and Joseph R. Robinson -- 41. Bioadhesive Drug Delivery Systems / A. David Woolfson, R. Karl Malcolm, Paul A. McCarron, and David S. Jones -- 42. Recent Developments in Drug Delivery to the Nervous System -- Dusica Maysinger, Radoslav Savic, Joseph Tam, Christine Allen, and Adi Eisenberg -- 43. Glucose-Mediated Insulin Delivery from Implantable Polymers / Larry R. Brown -- 44. Drug Targeting to the Kidney: The Low-Molecular-Weight Protein Approach / R.F.G. Haverdings, R.J. Kok, M. Haas, F. Moolenaar, D. de Zeeuw, and D.K.F. Meijer.
  • "In a carefully crafted, multidisciplinary, skillfully focused format, this book covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. It features small, readable monographs that provide a brief description of the evolving role of a particular material, and present topics in highly integrated, well-balanced, authoritatively prepared segments on materials processing and in vitro and in vivo evaluation, complete with case studies"-- Provided by publisher.