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  • Pneumococcal conjugate vaccines / Ger T. Rijkers -- Pneumococcal conjugate vaccines overview / Michael E. Pichichero -- Pneumococcal conjugate vaccines in children / Ingeborg S. Aaberge -- Pneumococcal vaccination in elderly / Ger T. Rijkers -- Pneumococcal conjugate vaccine in immunocompromised individuals / Marta C. Nunes & Shabir A. Madhi -- Pneumococcal conjugate vaccines in developing countries / Ener Cagri Dinleyici -- Current and future guidelines for pneumococcal conjugate vaccination / Elske van Gils, Ger Rijkers & Elisabeth Sanders -- Antibody response to pneumococcal polysaccharide vaccination in patients treated with biologicals / Minke Rab & Ger T. Rijkers -- Index.
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    The advent of type-specific antipneumococcal serotherapy -- A "specific" specific and the turbid age of applied immunology -- Fundamental tensions: clinical "proof" and clinical resistance -- The Massachusetts experiment and New (York) tensions -- The new standard, the new deal, and the pneumonia control programs -- Histology of a revolution -- A "modern" revolution: the limits and uses of controlled clinical trials -- The dismantling of pneumonia as a public health concern.
  • PNF (Proprioceptive Neuromuscular Facilitation) is a concept to therapeutic exercise which therapists all over the world have found effective for treating patients with a wide range of diagnoses. The approach presented in this richly illustrated guide is based on the concepts set out by Dr. Herman Kabat and taught by Margaret Knott. The fully revised fourth edition demonstrates how the principles of the International Classification of Functioning, Disability and Health (ICF) and aspects of motor learning and motor control (from hands-on to hands-off management) are applied in modern PNF evaluation and treatment. A new fresh fully-coloured design and layout highlights the clearly structured way in which philosophy, basic procedures and treatment patterns of PNF are based. New for this edition -Fully revised introductory chapter on the PNF basics, now including discussion and demonstration of ICF and Motor Learning aspects in detailed case study. -Throughout chapters, new additional case studies that help visualize the application of PNF applications in promoting the patients everyday-life motor skills on activity and participation levels.
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  • History / Marnae C. Ergil -- Fundamental theory of Chinese medicine / Kevin V. Ergil -- Diagnosis in Chinese medicine / Kevin V. Ergil -- Acupuncture / Marnae C. Ergil -- Tui na / Michael McCarthy and Kevin V. Ergil -- Traditional Chinese pharmacotherapy / Simon Becker -- Chinese dietetic / Mary Garvey -- Qi gong / Anne Reinard and Yves Réquéna -- Tai ji quan / Douglas Wile -- Acupuncture research : an overview / Stephen Birch.
  • Includes skull and oral tumor images
  • Examination -- Imaging and patient position -- Parasternal long-axis view -- Parasternal short-axis view -- Apical windows -- Suprasternal window -- Subcostal window -- M-mode and Doppler echocardiography -- M-mode -- Doppler -- Cardiac abnormalities -- Valvular heart disease -- Coronary heart disease -- Cardiomyopathies -- Prosthetic valves -- Carditis -- Septal defects -- Hypertensive heart diseases -- Intracardiac masses.
  • At a glance -- General anatomy -- Bones -- Sutures, joints, ligaments -- Muscles -- Tendon sheaths and bursae -- Alimentary system -- Respiratory system -- Urogenital system -- Abdominopelvic cavity -- Endocrine glands -- Heart -- Arteries -- Veins -- Lymphoid system -- Meninges -- Spinal cord -- Brain -- Cranial nerves -- Spinal nerves -- Autonomic nervous system -- Sense organs -- Skin and its appendages.
  • Anatomy / M. Grueb -- Optical system and physiology / M. Grueb -- Lids / M. Grueb -- Lacrimal apparatus / J. Mielke -- Orbit / J.M. Rohrbach, D. Holland -- Strabismus / H.-S. Walter -- Conjunctiva / J. M. Rohrbach -- Cornea / J. Mielke -- Sclera / T. Schlote -- Choroid and iris / T. Schlote -- Lens / J.M. Rohrbach -- Glaucoma / M. Grueb -- Retina and vitreous body / F. Gelisken -- Macula / U. Schneider -- Optic nerve and optic pathway / P. Weckerle -- Drug-induced ocular side-effects / T. Schlote -- Eye diseases in developing countries / J. Mielke.
  • White lesions -- Red lesions -- Black and brown lesions -- Vesiculobullous lesions -- Ulcerative lesions -- Papillary lesions -- Gingival enlargement -- Soft-tissue tumors -- Soft-tissue cysts -- Bone swellings -- Neck swellings -- Lip lesions.
  • Skull -- Spine -- Upper extremities -- Lower extremities -- Routine radiographs -- Spot images -- Tomography -- Gastrointestinal system -- Intravenous contrast studies -- Arthrography -- Arteriography -- Venograpy -- Special studies.
  • v. 2 Thieme
    "This comprehensive, easy-to-consult pocket atlas is renowned for its superb illustrations and ability to depict sectional anatomy in every plane. Together with its two companion volumes, it provides a highly specialized navigational tool for all clinicians who need to master radiologic anatomy and accurately interpret CT and MR images. Special features of Pocket Atlas of Sectional Anatomy: - Didactic organization in two-page units, with high-quality radiologic images on one side and brilliant, full-color diagrams on the other - Hundreds of high-resolution CT and MR images, many made with the latest generation of scanners (e.g., 3T MRI, 64-slice CT) - Consistent color coding, making it easy to identify similar structures across several slices - Concise, easy-to-read labeling of all figures. Updates for the 4th edition of Volume I: - New cranial CT imaging sequences of the axial and coronal temporal bone - Expanded MR section, with all new 3T MR images of the temporal lobe and hippocampus, basilar artery, cranial nerves, cavernous sinus, and more - New arterial MR angiography sequences of the neck and additional larynx images Compact, easy-to-use, highly visual, and designed for quick recall, this book is ideal for use in both the clinical and study settings. Volume I: Head and Neck Volume II: Thorax, Heart, Abdomen, and Pelvis, ISBN 978-3-13-125604-1 Volume III: Spine, Extremities, Joints, ISBN 978-3-13-143171-4 Torsten B. Moeller, MD, and Emil Reif, MD, Department of Radiology, Marienhaus Klinikum Saarlouis-Dillingen, Dillingen/Saarlouis, Germany"--Provided by publisher.
  • Pocket atlas of spine surgery 2012
    Thieme eNeurosurgery
    "This atlas will serve as a valuable resource not only for orthopedic surgeons, neurosurgeons, and surgical trainees such as residents and fellows, but also for physician assistants, nursing staff personnel, and anyone else involved in the operative care of patients undergoing spinal surgery"--Provided by publisher.
  • In this fully up-to-date Second Edition, experts in Chinese medicine explain how traditional Chinese tongue diagnosis can be used in daily practice to complement conventional Western methods. The guide begins with a brief introduction to the history, anatomy, physiology, and methodology of tongue diagnosis followed by basic techniques and systematic procedures for identifying the manifold individual characteristics of the tongue's shape and its many modifications. Full-color photographs of tongues then demonstrate a variety of clinical scenarios to help readers develop a holistic approach to diagnosis.
  • Section 1. Approach to the patient with renal disease -- section 2. Disturbances in control of body fluid volume and composition -- section 3. Epidemiology of renal disease -- section 4. Pathogenesis of renal disease -- section 5. Genetic basis of kidney disease -- section 6. Hypertension and the kidney -- section 7. The consequences of renal failure -- section 8. Conservation and pharmacologic management of kidney disease -- section 9. Invasive therapy of renal failure -- section 10. Renal transplantation.
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  • Pocket guide to diagnostic tests 2012 (6th ed.)
  • This book provides a concise, patient-directed approach to stone prevention. It defines who to evaluate and when to treat, and provides empiric guidelines for all stone formers. Specific treatment guidelines are also included, based on the kidney stone composition and the underlying metabolic abnormalities demonstrated by 24-hour urine stone risk profile. Written by experts in the field, Pocket Guide to Kidney Stone Prevention: Dietary and Medical Therapy serves as a valuable resource for a broad base of clinicians in primary and specialty care.
  • Neck pain and shooting arm pain -- Shoulder pain -- Elbow pain -- Wrist and hand pain -- Low back pain, hip pain, and shooting leg pain -- Knee pain -- Ankle pain -- Foot pain.
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    Acid-base and electrolyte disorders / Mildred Lam -- Cardiovascular system / Stephen N. Adler -- Endocrine/metabolic system / Thomas A. Murphy -- Gastrointestinal and hepatic systems / Wendell K. Clarkston, Patricia Sanchez, and Bruce R. Bacon -- Genitourinary system / Mildred Lam -- Hematologic system / Kyung-Whan Min -- Infectious disease / Debra Adler-Klein -- Integument / Dianne B. Gasbarra -- Musculoskeletal system / Dianne B. Gasbarra -- Nervous system / Stephen N. Adler -- Respiratory system / Dianne B. Gasbarra -- Human immunodeficiency virus infection / Debra Adler-Klein.
  • Pre-Operative Evaluation of the Thoracic Patient -- Operative and Post-Operative Considerations -- Lung and Airway Disorders -- Pleural Disorders -- Mediastinal Disorders -- Chest Wall Disorders -- Chest Trauma -- Benign Esophageal Disorders -- Esophageal Cancer.
  • History and physical examination -- Laboratory assessment -- Arthrocentesis and synovial fluid analysis -- Imaging techniques -- Monarticular joint disease -- Polyarticular joint disease -- Regional rheumatic pain syndromes -- Fibromyalgia and diffuse pain syndromes -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Psoriatic arthritis -- Ankylosing spondylitis -- Reactive and enteropathic arthritis -- Osteoarthritis -- Calcium pyrophosphate dehydrate, hydroxyapatite, and miscellaneous crystals -- Infectious disorders -- Systemic lupus erythematosus -- Antiphospholipid syndrome -- Systemic sclerosis -- Idiopathic inflammatory myopathies -- Metabolic myopathies -- Sjogren's syndrome -- Vasculitides -- Behcet's syndrome -- Adult Still's disease -- Autoinflammatory disorders/periodic syndromes -- Less common arthropathies -- Complex regional pain syndrome -- Osteonecrosis -- Paget's disease -- Osteoporosis -- Therapeutic injection -- Nonsteroidal anti-inflammatory drugs -- Glucocorticoids -- Operative treatment -- Complementary and alternative therapies.
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  • This Pocket Reference offer a multifaceted guide on various aspects of Alzheimerℓ́ℓs disease. This thorough review discusses the challenges of diagnosis, different stages of the disease, testing, and current treatment methods, including pharmacological and nonpharmacological management of cognitive decline and symptoms due to Alzheimerℓ́ℓs disease. The book also has specific chapters on care issues for patients with Alzheimerℓ́ℓs disease, which describes what clinician's and caregivers should expect and how to manage the disease at its various stages. Additionally, the book provides helpful guides, tables, and tips for clinicians and caregivers to help care for the patient and the caregiver themselves.
  • Pocket Reference to Renal Anemia, Second edition, provides a comprehensive overview of anemia in patients with renal disease, including the definition and causes of renal anemia, current management approaches, and the latest clinical practice guidelines. Key learning points are highlighted throughout the book and also listed at the end of the book for a quick reference. The book is useful for general physicians, fellows, and other healthcare professionals wishing to learn more about renal anemia.
  • Medical management -- Imaging of the spine / Donna D. Ohnmeiss, Hector Soriano-Baron, Eduardo Martinez-del-Campo, Nicholas Theodore, Camden Whitaker -- Head and spine trauma / Camden Whitaker, Rob D. Dickerman, Ryan Stuckey -- Cervical degenerative disc disease -- Rheumatoid arthritis of the cervical spine -- Spinal deformities in pediatric, adolescent, and adult patients / Camden Whitaker, Ryan Stuckey -- Lumbar radiculopathy -- Compression fractures and osteoporosis / Camden Whitaker, Ryan Stuckey -- Low back pain / Camden Whitaker, Ryan Stuckey -- Spinal stenosis -- Diagnosis and treatment of sacroiliac joint pain (sacrogenic pain) / Ralph F. Rashbaum -- Spinal cord tumors / Rob D. Dickerman.
  • Podocytopathy 2014
    Cell biology of the podocyte / Jefferson, J.A.; Shankland, S.J. -- Cell cycle and podocyte injury / Hagmann, H.H.; Shankland, S.J.; Brinkkoetter, P.T. -- The podocyte cytoskeleton : key to a functioning glomerulus in health and disease / Faul, C. -- Crosstalk between podocytes and tubular epithelial cells / Leung, J.C.K.; Kar, N.L.; Tang, S.C.W. -- Role of mitochondria in podocyte injury / Yuan, Y.; Huang, S.; Zhang, A. -- Autophagy in podocytes / Zhang, L.; Livingston, M.J.; Chen, J.-K.; Dong, Z. -- PPAR- : signaling in podocyte injury / Wang, W.; Yang, T. -- Podocyte injury in FSGS / Ding, W.Y.; Saleem, M.A. -- Circulating soluble urokinase receptor and focal segmental glomerulosclerosis / Wei, C.; Reiser, J. -- Anti-phospholipase A2 receptor-1 autoantibodies and membranous nephropathy / Beck, L.H. -- Anti-neutral endopeptidase antibodies, autoantibodies, anti-bovine serum albumin antibodies and membranous nephropathy / Ronco, P.; Debiec, H. -- Podocytopathy in diabetes : a metabolic disorder / Merscher, S.; Lenz, O.; Fornoni, A. -- Obesity-related glomerulopathy and podocyte injury / Camici, M. -- Podocyte injury in HIV-associated nephropathy / Mallipattu, S.K.; He, J.C. -- Retinoic acid : a potential pharmacologic approach in the treatment of podocytopathy / Sharma, S.; Mallipattu, S.K.; Zhong, Y.; He, J.C. -- Immunomodulatory drugs and the podocyte / Mathieson, P.W. -- Triptolide protects podocytes from injury / Qin, W.; Liu, Z.-H. -- Fly : a model to study the podocyte / Na, J.; Cagan, R.L. -- Zebrafish models of podocytopathies / Boucher, R.C.; Zhou, W. -- The role of micrornas in podocytes / Shi, S.; Liu, Z.-H. -- An integrative biology approach to study podocyte function / Ju, W.; Hodgin, J.; Jiang, S.; Kretzler, M.
  • The Poincaré plot (named after Henri Poincaré) is a popular two-dimensional visualization tool for dynamic systems due to its intuitive display of the dynamic properties of a system from a time series. This book presents the basis of Poincaré plot and focus especially on traditional and new methods for analysing the geometry, temporal and spatial dynamics disclosed by the Poincaré plot to evaluate heart rate variability (HRV). Mathematical descriptors of Poincaré plot have been developed to quantify the autonomic nervous system activity (sympathetic and parasympathetic modulation of heart rate). Poincaré plot analysis has also been used in various clinical diagnostic settings like diabetes, chronic heart failure, chronic renal failure and sleep apnea syndrome. The primary aims of quantification of the Poincaré plots are to discriminate healthy physiological systems from pathological conditions and to classify the stage of a disease. The HRV analysis by Poincaré plot has opened up ample opportunities for important clinical and research applications. Therefore, the present book can be used either for self-study, as a supplement to courses in linear and nonlinear systems, or as a modern monograph by researchers in this field of HRV analysis.
  • Point of care ultrasound 2015
    With portable, hand-carried ultrasound devices being more frequently implemented in medicine today, Point-of-Care Ultrasound will be a welcome resource for any physician or health care practitioner looking to further their knowledge and skills in point-of-care ultrasound. This comprehensive, portable handbook offers an easy-access format that combines electronic content and peer-reviewed videos to provide comprehensive, non-specialty-specific guidance on this ever-evolving technology. Access all the facts with focused chapters covering a diverse range of topics, as well as case-based examples that include ultrasound scans and videos.Understand the pearls and pitfalls of point-of-care ultrasound through contributions from experts at more than 30 institutions. View techniques more clearly than ever before. Illustrations and photos include transducer position, cross-sectional anatomy, ultrasound cross sections, and ultrasound images.Watch more than 200 ultrasound videos from real-life patients that demonstrate key findings. Available at Expert Consult, these videos are complemented by anatomical illustrations and text descriptions to maximize learning.
  • Sect. I. Comprehensive evaluation and treatment -- Sect. II. Specific poisons and drugs: diagnosis and treatment -- Sect. III. Therapeutic drugs and antidotes -- Sect. IV. Environmental and occupational toxicology.
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  • Introduction: Understanding the Management of Police Services -- Historical Perspective: British Policing and the Democratic Ideal -- Part 2- Context of Policing -- Quo Vadis: A New Direction for Police Leadership through Community Engagement? -- Initial police training and the development of police occupational culture -- Community Engagement, Democracy and Public Policy: a Practitioner Perspective -- Dealing with Diversity in Police Services -- Risk Management in Policing -- Perspectives on the Essence of Policing -- Part 3- Current debates in Policing -- Enhancing Police Accountability in England and Wales: What differences are Police and Crime Commissioners making? -- Police management and workforce reform in a period of austerity -- Personal Resilience and Policing -- Part 4- Looking to the Future -- Some Futures for the Police: Scenarios and Science -- The Future of Policing in the United Kingdom -- A Crisis or a Perfect Storm: the trouble with Public Policing?.-International Perspectives in Policing: Challenges for 2020.-International perspectives in policing: Challenges for 2020.
  • Enzymes in poly(ADP-ribose) metabolism / Ralph G. Meyer ... [et al.] -- PARP-2: structure-function relationship / Valørie Schreiber ... [et al.] -- Targeting the poly(ADP-ribose) glycohydrolase (PARG) gene in mammals / Ulrich Cortes and Zhao-Qi Wang -- DNA damage signaling through poly(ADP-ribose) / Maria Malanga and Felix R. Althaus -- Roles of poly(ADP-ribose) metabolism in the regulation of centrosome duplication and in the maintenance of neuronal integrity / Masanao Miwa ... [et al.] -- Functional interactions of PARP-1 with p53 / Rafael Alvarez-Gonzalez ... [et al.] -- Dynamic interaction between PARP-1, PCNA and p21waf1/cip1 / Ennio Prosperi and A. Ivana Scovassi -- Parp-1 as novel coactivator of NF-kB in inflammatory disorders / Paul O. Hassa and Michael O. Hottiger -- PARP and epigenetic regulation / Paola Caiafa -- PARP and the release of apoptosis-inducing factor from mitochondria / Suk Jin Hong, Ted M. Dawson and Valina L. Dawson -- Genome degradation by DNAS1L3 endonuclease: a key PARP-1-regulated event in apoptosis / A. Hamid Boulares, Alexander G. Yakovlev and Mark E. Smulson -- NAD-metabolism and regulatory functions / Mathias Ziegler -- PARP-1 and the shape of cell death / Laszlø Virøg -- Poly(ADP-ribose) polymerase (PARP) and excitotoxicity / Domenico E. Pellegrini-Giampietro, Alberto Chiarugi and Flavio Moroni -- Poly(ADP-ribose) polymerase and ischemia-reperfusion injury / Prabal K. Chatterjee and Christoph Thiemermann -- Role of poly(ADP-ribose) polymerase activation in the pathogenesis of inflammation and circulatory shock / Csaba Szabø -- Role of poly-ADP-ribosylation in cancer development / Mitsuko Masutani ... [et al.] -- PARP inhibitors and cancer therapy / Nicola J. Curtin -- Poly(ADP-ribosyl)ation and aging / Sascha Beneke and Alexander Bürkle.
  • Polyamine structure and synthetic analogs / Patrick M. Woster -- Acute increases in intracellular putrescine lead to the increase in steady-state levels of c-fos, c-jun, RING3, and Id-1 mRNAs / Allan A. Ancheta, Leo Hawel III, and Craig V. Byus -- Polyamine-dependent early cellular signals and cell proliferation / Stina M. Oredsson -- Cellular signals mediating growth arrest after polyamine depletion / Jian-Ying Wang -- Role of polyamines in the regulation of chromatin acetylation / Cheryl A. Hobbs and Susan K. Gilmour -- Role of polyamines in regulation of sequence-specific DNA binding activity / Sripriya Venkiteswaran, Thresia Thomas, and T.J. Thomas -- Polyamine metabolism and the hypertrophic heart / Lisa M. Shantz and Emanuele Giordano -- Influence of polyamines on breast cancer biology / Andrea Manni -- Polyamines in regulation of prostatic cell growth / Raymond G. Schipper ... [et al.] -- Polyamines and cytoskeletal regulation during intestinal epithelial restitution / Ramesh M. Ray and Leonard R. Johnson -- Regulation of Kv channel activity and intercellular junctions by polyamines in intestinal epithelial cells / Jaladanki N. Rao and Jian-Ying Wang -- Polyamine block of Kir channels: toward a molecular picture / Harley T. Kurata and Colin G. Nichols -- Regulation of ornithine decarboxylase expression / Lo Persson -- Evidence for a multistep model for eukaryotic polyamine transport / Richard Poulin ... [et al.] -- Bacterial and eukaryotic transport systems / Kazuei Igarashi and Keiko Kashiwagi -- Regulation of S-adenosylmethionine decarboxylase / Colin Hanfrey -- Genetic engineering of polyamine catabolism in transgenic mice and rats / Juhani Jänne ... [et al.]. Polyamines in kidney biology / Joseph Satriano -- Polyamines in pulmonary vascular biology / Jack W. Olson and Mark N. Gillespie -- Recent advances in the understanding of mammalian polyamine catabolism: the regulation and potential role of polyamine catabolism in drug response and disease processes / Robert A. Casero, Jr. ... [et al.] -- Cellular signaling and polyamines in the control of apoptosis in intestinal epithelial cells / Leonard R. Johnson and Ramesh M. Ray -- The role of ornithine decarboxylase in Myc-induced tumorigenesis / Jonas A. Nilsson and John L. Cleveland -- Protective effect of polyamines on NSAID-induced injury and apoptosis / Heather M. Wallace and Alun Hughes -- Role of polyamines in the control of the immune response in the brain / Denis Soulet and Serge Rivest -- Implication of polyamines in apoptosis of immunoresponse cells / Rupesh Chaturvedi and Keith T. Wilson -- Polyamines and cancer / Ajit K. Verma -- Polyamine pools and cancer prevention / Eugene W. Gerner and David E. Stringer --
  • Polyamines
  • Polyamines-- methods and protocols 2011
    Springer Protocols
    [Publisher-supplied data] Recently, important new findings in the polyamine field and a variety of new experimental systems have revolutionized the study of these ubiquitous cellular components, essential for normal growth and development. In Polyamines: Methods and Protocols, leading researchers contribute an extensive collection of up-to-date laboratory techniques for the further pursuit of polyamine study. The volume delves into vital subjects such as neoplasia studies with animal models and human patients, therapeutic roles for polyamine inhibitors and analogs, polyamine metabolism and oxidative damage, polyamines as regulators of critical ion channels, as well as polyamine transport systems and polyamine-responsive genes. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and expert notes on troubleshooting and avoiding known pitfalls. Comprehensive and cutting-edge, Polyamines: Methods and Protocols provides a key resource for all scientists pursuing the study of this dynamic and significant aspect of cellular biology.
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  • Polycystic ovary syndrome : definitions, phenotypes and diagnostic approach / S. Livadas, E. Diamanti-Kandarakis -- Pathophysiology of polycystic ovary syndrome : the role of hyperandrogenism / S. Catteau-Jonard, D. Dewailly -- Genetics of polycystic ovary syndrome / T.M. Barber, S. Franks -- Obesity, adipokines and metabolic syndrome in polycystic ovary syndrome / E. Carmina -- Dyslipidemia and oxidative stress in PCOs / D. Macut, J. Bjekić-Macut, A. Savić-Radojević -- Cardiovascular risk and subclinical cardiovascular disease in polycystic ovary syndrome / K. Bajuk Studen, M. Jensterle Sever, M. Pfeifer -- Insulin sensitizers in polycystic ovary syndrome / R. Pasquali, A. Gambineri -- Hirsutism : from diagnosis to use of antiandrogens / K. Unluhizarci, Z. Karaca, F. Kelestimur -- Combined oral contraceptives in polycystic ovary syndrome : indications and cautions / G. Bozdag, B.O. Yildiz -- Infertility treatment in polycystic ovary syndrome : lifestyle interventions, medications and surgery / D. Panidis ... [et. al.] -- Endocrinopathies and other disorders inducing a polycystic ovary syndome phenotype / K.I. Alexandraki, G.A. Kaltsas -- Non-classic adrenal hyperplasia due to the deficiency of 21-hydroxylase and its relation to polycystic ovarian syndrome / D. Pignatelli.
  • Presenting an overview of the current understanding of the pathophysiology of PCOS and a paradigm for the clinical evaluation and management of the disorder, Polycystic Ovary Syndrome is written in an easy to digest, concise format that, with bulleted key points introducing each chapter, is suitable for the trainee and the busy clinician. The breadth and depth of coverage of today's queries and controversies will be of particular interest to the specialist and researcher. An international group of leading experts addresses the varied etiologies of PCOS, comprehensively covering the contemporary treatment approaches and long-term implications of PCOS, a common yet poorly understood disorder. Chapters on treatment will be of particular relevance to the clinician and the trainee as they cover conventional therapies, lifestyle, and diet, as well as address emerging strategies such as the use of statins and surgery in PCOS management. Spanning the breadth of clinical presentations and morbidities related to the diagnosis of PCOS, Polycystic Ovary Syndrome is an exceptional resource for primary care providers, gynecologists, reproductive endocrinologists, and others involved in the care of these patients, and provides the essential tools to aid clinicians in initiating a timely diagnostic workup and appropriate interventions to address both the immediate and long-term sequelae related to PCOS.
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  • Introduction / Joseph Seckbach, Aharon Oren, and Helga Stan-Lotter -- Foreword / Richard W. Castenholz -- Preface / Koki Horikoshi -- Editors' biographies -- List of authors and their addresses -- Polyextremophiles and the constraints for terrestrial habitability / M.C. Capece et al. -- Life on the edge and astrobiology : who is who in the polyextremophiles world? / J. Seckbach -- The dynamic genomes of acidophiles / F.J. López de Saro et al. -- Two centuries of microbiological research in the Wadi Natrun, Egypt : a model system for the study of the ecology, physiology, and taxonomy of haloalkaliphilic microorganisms / A. Oren -- Adaptation in haloalkaliphiles and natronophilic bacteria / H.L. Banciu and D.Y. Sorokin -- A random biogeochemical walk into three soda lakes of the western USA : with an introduction to a few of their microbial denizens / R.S. Oremland -- Halophilic, acidophilic, and haloacidophilic prokaryotes / H. Minegishi -- Life in magnesium- and calcium-rich hypersaline environments : salt stress by chaotropic ions / A. Oren -- Survival strategies of halophilic oligotrophic and desiccation resistant prokaryotes / H. Stan-Lotter and S. Fendrihan -- Radiation resistance in extremophiles : fending off multiple attacks / K.M. Webb and J. DiRuggiero -- Thermoalkaliphilic microbes / V. Kumar and T. Satyanarayana -- Acido- and thermophilic microorganisms : their features, and the identification of novel enzymes or pathways / Y. Kawarabayasi -- Microbial diversity in acidic high-temperature steam vents / R.L. Weiss Bizzoco and S.T. Kelley -- Left out in the cold : life in cryoenvironments / J. Goordial et al. -- Microbial diversity and enzymes in ikaite columns : a cold and alkaline environment in Greenland / J.K. Vester et al. -- Microbial communities thriving in various ice ecosystems / B. Sattler et al. -- Snow algae : adaptation strategies to survive on snow and ice / T. Leya -- Adaptation of Antarctic freshwater green algae to extreme environments / H. Hu -- Deep subsurface oil reservoirs as poly-extreme habitats for microbial life. A current review / A. Wentzel et al. -- Expanding limits for life to a new dimension : microbial growth at hypergravity / S. Deguchi and K. Horikoshi -- Microbial eukaryotes in marine oxygen minimum zones / W.D. Orsi and V.P. Edgcomb -- Deep hypersaline anoxic basins as model systems for environmental selection of microbial plankton / A. Stock et al. -- Microbial eukaryotes in hypersaline anoxic deep-sea basins / V.P. Edgcomb and W.D. Orsi -- Life at high salt and low oxygen : how do the Halobacteriaceae cope with low oxygen concentrations in their environment? / A. Oren -- Niches and adaptations of polyextremotolerant black fungi / M. Grube et al. -- Polyextremophilic photoautotrophic eukaryotic algae / W. Reisser -- Extremophilic magnetotactic bacteria / C.T. Lefèvre and D.A. Bazylinski -- Tardigrades : an example of multicellular extremophiles / D. Schulze-Makuch and J. Seckbach -- Polyextremophiles : summary and conclusions / J. Chela-Flores.
  • Part I. Polymers as Biomaterials -- 1. Polysaccharides as Biomaterials / Severian Dumitriu -- 2. Biomimetics / Weiyuan John Kao -- 3. Silicones for Pharmaceutical and Biomedical Applications / Haissam S. El-Zaim and John P. Heggers -- 4. Biodegradable Polymers as Drug Carrier Systems / Abraham J. Domb, Neeraj Kumar, Tzviel Sheskin, Alfonso Bentolila, Joram Slager, and Doron Teomim -- 5. Biodegradable Biomaterials Having Nitric Oxide Biological Activity / C.C. Chu -- 6. Hydrogels for Biomedical and Pharmaceutical Applications / Akio Kishida and Yoshito Ikada -- 7. Mucoadhesive Polymers / Andreas Bernkop-Schnürch -- 8. Polymers for Tissue Engineering Scaffolds / Howard W.T. Matthew -- 9. Chitosan: Structure-Properties Relationship and Biomedical Applications / Alain Domard and Monique Domard -- 10. Chitosan-Based Delivery Systems: Physicochemical Properties and Pharmaceutical Applications / Radi Hejazi and Monsoor Amiji -- 11. Immobilization of Active Biopolymers from Cold Plasma-Functionalized Surfaces for the Creation of Molecular Recognition and Molecular Manufacturing Systems / Ferencz Denes and Sorin Manolache -- 12. Advances in Designed Multivalent Bioconjugates with Dendritic Structure / Bogdan Comanita -- 13. Biocompatibility of Elastomers / D.J. Chauvel-Lebret, P. Auroy, and M. Bonnaure-Mallet -- 14. Control of Cell-Biomaterial Interactions / Danielle C. Giliberti, Kyle K. White, and Kay C Dee -- Part II. Medical and Pharmaceutical Applications of Polymers -- 15. Polymeric Systems for Ophthalmic Drug Delivery / O. Felt, S. Einmahl, P. Furrer, V. Baeyens, and R. Gurny -- 16. Dental and Maxillofacial Surgery Applications of Polymers ? A. Bascones, J. M. Vega, N. Olmo, J. Turnay, J.G. Gavilanes, and M.A. Lizarbe -- 17. Biomaterials in Bum and Wound Dressings / Robert L. Sheridan, Jeffrey R. Morgan, and Rashid Mohammad -- 18. Dermocosmetic Applications of Polymeric Biomaterials / P. Corvi Mora and P.G. Baraldi -- 19. Textile-Based Biomaterials for Surgical Applications / C.C. Chu -- 20. Bioabsorbable Polymers for Medical Applications with an Emphasis on Orthopedic Surgery / Pentti U. Rokkanen -- 21. Polymers for Artificial Joints / Naohide Tomita, Kazuya Nagata, and Hiroshi Fujita -- 22. Polymeric Occluders in Tilting Disc Heart Valve Prostheses / G.S. Bhuvaneshwar, A.V. Ramani, and K.B. Chandran -- 23. Blood-Contacting Polymers / T. Avramoglou, J. Jozefonvicz, and M. Jozefowicz -- 24. Surface Modification of Dacron Vascular Grafts: Incorporation of Antithrombin and Mitogenic Properties / Matthew D. Phaneuf Martin J. Bide, William C. Quist, and Frank W. LoGerfo -- 25. Antithrombin-Heparin Complexes / Leslie R. Berry, Maureen Andrew, and Anthony K.C. Chan -- 26. Adhesives for Medical Applications / lain Webster and Peter J. West -- 27. Glucose-Sensitive Hydrogel Membranes / Jin Ho Lee, Jung Ju Kim, and Kinam Park -- 28. Polymeric Micro- and Nanoparticles as Drug Carriers / G. Barratt, G. Couarraze, P. Couvreur, C. Dubernet, E. Fattal, R. Gref, D. Labarre, P. Legrand, G. Ponchel, and C. Vauthier -- 29. Liposomes in Drug Delivery / Yuan-Peng Zhang, Boris Ceh, and Danilo D. Lasic -- 30. Liposomes for Cancer Therapy Applications / Lawrence D. Mayer, Rajesh Krishna, and Marcel B. Bally -- 31. Systemic Cancer Therapy Using Polymer-Based Prodrugs and Progenes / Leonard W. Seymour -- 32. Anticancer Drug Conjugates with Macromolecular Carriers / F. Kratz, A. Warnecke, K. Riebeseel, and P.C.A. Rodrigues -- 33. Enzyme-Prodrug Therapies of Cancer / Richard J. Knox, Roger G. Melton, and Ronit Satchi -- 34. New Lipid/DNA Complexes for Gene Delivery / Kenneth W. Liang and Leaf Huang -- 35. Gene Delivery by Cationic Liposome-DNA Complexes / Nejat Düzgüneş, Sérgio Simões, Pedro Pires, and Maria C. Pedroso de Lima -- 36. Biological Stimulus-Responsive Hydrogels / Takashi Miyata and Tadashi Uragami -- 37. Biocompatible Polymers in Liver-Targeted Gene Delivery Systems / Edwin C. Ouyang, George Y. Wu, and Catherine H. Wu -- 38. Bioartificial Pancreas / Riccardo Calafiore -- 39. Transdermal Delivery of Drugs / B.B. Michniak and A. El-Kattan -- 40. Drug Delivery via Mucosal Routes / Nimit Worakul and Joseph R. Robinson -- 41. Bioadhesive Drug Delivery Systems / A. David Woolfson, R. Karl Malcolm, Paul A. McCarron, and David S. Jones -- 42. Recent Developments in Drug Delivery to the Nervous System -- Dusica Maysinger, Radoslav Savic, Joseph Tam, Christine Allen, and Adi Eisenberg -- 43. Glucose-Mediated Insulin Delivery from Implantable Polymers / Larry R. Brown -- 44. Drug Targeting to the Kidney: The Low-Molecular-Weight Protein Approach / R.F.G. Haverdings, R.J. Kok, M. Haas, F. Moolenaar, D. de Zeeuw, and D.K.F. Meijer.
  • "In a carefully crafted, multidisciplinary, skillfully focused format, this book covers attributes of polymers used for vascular, urological, and gynecological materials. It provides a brief analysis of how the use of polymers in vascular and urogenital applications has evolved in the past five decades and outlines their common and specific functional requirements. It features small, readable monographs that provide a brief description of the evolving role of a particular material, and present topics in highly integrated, well-balanced, authoritatively prepared segments on materials processing and in vitro and in vivo evaluation, complete with case studies"-- Provided by publisher.
  • Polymyalgia Rheumatica and Giant Cell Arteritis - an overview with a focus on important factors contributing to the severity of the disease / Jozef Rovenský, Burkhard F. Leeb, Viera Štvrtinová, Richard Imrich and Juraj Duda -- Polymyalgia Rheumatica, Temporal Arteritis and Occurrence of Malignant Tumors / Jozef Rovenský and Alena Tuchyňová -- Coronary involvement and atherosclerosis in Giant Cell Arteritis / Viera Štvrtinová, Jozef Rovenský and Alena Tuchyňová -- T cells and their role in Polymyalgia Rheumatica and Giant Cell Arteritis / Stanislava Blažíčková and Jozef Rovenský -- Cytokines in Polymyalgia Rheumatica and Giant Cell Arteritis / Jozef Rovenský and Richard Imrich -- Genetic factors in Giant Cell Arteritis and Polymyalgia Rheumatica / Vladimír Bošák -- Polymyalgia rheumatica (PMR) and vascular complications / Viera Štvrtinová, Svetoslav Štvrtina and Jozef Rovenský -- Chronobiology of Polymyalgia Rheumatica and Giant Cell Arteritis / Howard Bird -- Histopathology of Giant Cell (temporal) Arteritis - changes in aorta / Svetoslav Štvrtina and Jozef Rovenský -- Ultrasonography in Polymyalgia Rheumatica and/or Giant Cell Arteritis / Peter Poprac and Jozef Rovenský -- Therapy of Polymyalgia Rheumatica and Giant Cell Arteritis / Jozef Rovenský and Richard Imrich -- Diagnostic Criteria, Treatment, and Monitoring of Polymyalgia Rheumatica/Giant Cell Arteritis / Burkhard F. Leeb, Thomas Nothnagl, Martin Steindl and Bernhard Rintelen.
  • Polyomaviruses and human diseases / Nasimul Ahsan and Keerti V. Shah -- Discovery and epidemiology of the human polyomaviruses BK virus (BKV) and JC virus (JCV) / Wendy A. Knowles -- Phylogenomics and molecular evolution of polyomaviruses / Keith A. Crandall ... [et al.] -- Virus receptors and tropism / Aarthi Ashok and Walter J. Atwood -- Serological cross reactivity between polyomavirus capsids / Raphael P. Viscidi and Barbara Clayman -- Molecular genetics of the BK virus / Christopher L. Cubitt -- Serological diagnosis of human polyomavirus infection / Annika Lundstig and Joakim Dillner -- Human polyomavirus JC and BK persistent infection / Kristina Doerries -- Immunity and autoimmunity induced by polyomaviruses / Ole Petter Rekvig, Signy Bendiksen, and Ugo Moens -- The pathobiology of polyomavirus virus infection in man / Parmjeet Randhawa, Abhay Vats, and Ron Shapiro -- Polymoavirus-associated nephropathy in renal transplantation / Hans H. Hirsch ... [et al.] -- BK virus and immunosuppressive agents / Irfan Agha and Daniel C. Brennan -- BK virus infection after non-renal transplantation / Martha Pavlakis, Abdolreza Haririan, and David K. Klassen -- Latent and productive polyomavirus infections of renal allografts / Volker Nickeleit, Harsharan K. Singh, and Michael J. Mihatsch -- Urine cytology findings of polyomavirus infections / Harsharan K. Singh ... [et al.] -- Diagnosis and treatment of BK virus-associated transplant nephropathy / Abhay Vats, Parmjeet S. Randhawa, and Ron Shapiro -- Pharmacotherapeutic options for the management of human polyomaviruses / Julie Roskopf ... [et al.] -- Leflunomide in solid organ transplantation and polyoma virus infection / Michelle A. Josephson ... [et al.] -- JC virus can infect human immune and nervous system progenitor cells / Jean Hou, Pankaj Seth, and Eugene O. Major -- The polyomavirus, JCV, and its involvement in human disease / Kamel Khalili, Jennifer Gordon, and Martyn K. White -- Transforming activities of JC virus early proteins / Richard J. Frisque, Catherine Hofstetter, and Shiva K. Tyagarajan -- Polyomavirus in human cancer development / Winston Lee and Erik Langhoff -- BK virus, JC virus, and simian virus 40 infection in humans and association with human tumors / Giuseppe Barbanti-Brodano ... [et al.] -- Epidemiologic studies of polyomaviruses and cancer / Dana E.M. Rollison.
  • Although monotherapy is generally recommended as the treatment of choice, treatment resistance of patients with psychosis, cognitive, mood and anxiety disorders represents a significant clinical problem. In this context, augmentation and combination strategies are commonly employed to address this problem. Although multiple medication use common in psychiatric practice, reasons, efficacy and safety for polypharmacy, and augmentative strategies have remained unclear. It remains unclear if there is an evidence base to support polypharmacy. Furthermore, excessive and inappropriate use of psychotropic medications has been recognized as a public health problem.
  • Polyphenols in Human Health and Disease documents antioxidant actions of polyphenols in protection of cells and cell organelles, critical for understanding their health-promoting actions to help the dietary supplement industry. The book begins by describing the fundamentals of absorption, metabolism and bioavailability of polyphenols, as well as the effect of microbes on polyphenol structure and function and toxicity. It then examines the role of polyphenols in the treatment of chronic disease, including vascular and cardiac health, obesity and diabetes therapy, cancer treatment and prevention, and more. Explores neuronal protection by polyphenol metabolites and their application to medical care. Defines modulation of enzyme actions to help researchers see and study polyphenols' mechanisms of action, leading to clinical applications. Includes insights on polyphenols in brain and neurological functions to apply them to the wide range of aging diseases.
  • Polyploidy, aneuploidy, and the evolution of cancer / Lauren M.F. Merlo ... [et al.] -- Molecular mechanisms and function of the spindle checkpoint : a guardian of the chromosome stability / Daisuke Ito and Tomohiro Matsumoto -- Understanding cytokinesis failure / Guillaume Normand and Randall W. King -- DNA damage and polyploidization / Jeremy P.H. Chow and Randy Y.C. Poon -- Role of the p53 family in stabilizing the genome and preventing polyploidization / Flaminia Talos and Ute M. Moll -- Centrosomes, polyploidy, and cancer / Anette Duensing and Stefan Duensing -- Polyploidy : mechanisms and cancer promotion in hematopoietic and other cells / Hao G. Nguyen and Katya Ravid -- Polyploidization of liver cells / Séverine Celton-Morizur and Chantal Desdouets -- Analysis of cellular DNA content by flow and laser scanning cytometry / Zbigniew Darzynkiewicz, H. Dorota Halicka, and Hong Zhao.
  • Pomegranate phytochemicals / Navindra P. Seeram ... [et al.] -- Antioxidative properties of pomegranate : in vitro studies / Mira Rosenblat and Michael Aviram -- Bioavailability of pomegranate polyphenols / Francisco A. Tomas-Barberan, Navindra P. Seeram, and Juan Carlos Espin -- Protection against cardiovascular disease / Bianca Fuhrman and Michael Aviram -- Protection against stroke / Marva I. Sweeney-Nixon -- Anticancer potential of pomegranate / Shishir Shishodia ... [et al.] -- Molecular mechanisms of chemoprevention of cancer by pomegranate / Deeba Syed ... [et al.] -- Pomegranate and prostate cancer chemoprevention / John T. Leppert and Allan J. Pantuck -- Accessment of estrogenicity of pomegranate in an in vitro bioassay / Diane M. Harris, Emily Besselink, and Navindra P. Seeram -- Absence of significant estrogenic effects in the postmenopausal population / Michelle P. Warren ... [et al.] -- Antimicrobial activities of pomegranate / G.K. Jayaprakasha, P.S. Negi, B.S. Jena -- Commercialization of pomegranates : fresh fruit, beverages, and botanical extracts / Navindra P. Seeram, Yanjun Zhang, and David Heber -- Pomegranates: a botanical perspective / David W. Still -- Postharvest biology and technology of pomegranates / Adel A. Kader.
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    Antecedents: poverty and early poverty care programs -- Precursors to Medicare and Medicaid -- War on poverty and the genesis of Medicaid -- Hard-to-reach groups -- Redefining health -- Charity care and comprehensive reform under Nixon -- Health planning and community medicine in the 1970s -- Health and welfare reform in the Carter White House -- Block grants and the new federalism -- Recovering the cuts, managed care, and comprehensive reform -- Managed Medicaid, AIDS, and the Clinton health bill.
  • "In the 1860s and 1870s, leading neurologists used animal experimentation to establish that discrete sections of the brain regulate specific mental and physical functions. These discoveries had immediate medical benefits: David Ferrier's detailed cortical maps, for example, saved lives by helping surgeons locate brain tumors and haemorrhages without first opening up the skull. These experiments both incited controversy and stimulated creative thought, because they challenged the possibility of an extra-corporeal soul. This book examines the cultural impact of neurological experiments on late Victorian Gothic romances by Robert Louis Stevenson, Bram Stoker, H. G. Wells and others. Novels like Dracula and Jekyll and Hyde expressed the deep-seated fears and visionary possibilities suggested by cerebral localization research and offered a corrective to the linearity and objectivity of late Victorian neurology"--Provided by publisher.
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  • "Assess the effects of tobacco control programs or public policy changes on smoking behavior."
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    Thinking like a population geneticist -- Genotype frequencies -- Genetic drift and effective population size -- Population structure and gene flow -- Mutation -- Fundamentals of natural selection -- Further models of natural selection -- Molecular evolution -- Quantitative trait variation and evolution -- The Mendelian basis of quantitative trait variation -- Historical and synthetic topics.
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  • Bridging the divide: population mobility and the emergence of disease. Demographic and epidemiological perspectives of human movement / Yorghos Apostolopoulos and Sevil Sönmez -- Key themes pertinent to migration, health, and disease. Population mobility and the geography of microbial threats / Mary E. Wilson -- Health barriers and inequities for migrants / Elizabeth Ioannidi-Kapolou -- Social networks, social capital, and HIV risks among migrants / Varda Soskolne -- Labor induced migration and disease diffusion. Economic migrants and health vulnerability / Mark N. Lurie -- Military personnel: on the move and vulnerable/AIDS to HIV and other STIs / Stuart J. Kingma and Rodger D. Yeager -- Selling sex in the era of AIDS: mobile sexworkers and STI/HIV risks / Natalya Timoshkina, Anthony P. Lombardo, and Lynn McDonald -- Tracing the diffusion of infectious diseases in the transport sector / Yorghos Apostolopoulos and Sevil Sönmez -- Forced migration: a public health catastrophe. War, refugees, migration, and public health: do infectious diseases matter? / Frederick M. Burkle -- Natural disasters, climate change, and the health of mobile populations / Jonathan D. Mayer -- Leisure migration and health concerns: a paradox or inevitability? Casual sex in the sun makes the holiday: young tourists' perspectives / Eugenia Wickens and Sevil Sönmez -- In search of the exotic: sex tourism and disease risks / Sevil Sönmez, Eugenia Wickens, and Yorghos Apostolopoulos -- New directions in migration health and medicine. Mapping and modeling disease risk among mobile populations / Henry G. Mwambi and Khangelani Zuma -- Ethical and legal issues impacting migrant health / Sana Loue -- Migration in a mobile world: health, population mobility, and emerging disease / Brian D. Gushulak and Douglas W. MacPherson.
  • Terms and Concepts -- History of the Key Disciplines -- Enviromics -- Genomics -- Epigenomics -- Molecular Phenomics -- Systems Phenomics -- Cohorts -- Challenges -- Personalized Preventive Medicine.
  • Chapter 1. Introduction -- Chapter 2. Mentors/Advisors -- Chapter 3. The Transition?Part 1 -- Chapter 4. Attire -- Chapter 5. The Little Black Book -- Chapter 6. Communications -- Chapter 7. Teaching and Learning -- Chapter 8. Surgery Suite Etiquette -- Chapter 9. The Clinics -- Chapter 10. Rounds -- Chapter 11. The Difficult -- Chapter 12. Documentation -- Chapter 13. Presentations -- Chapter 14. Mortality and Morbidity Conference -- Chapter 15. On Call -- Chapter 16. Family and Friends -- Chapter 17. Your Health -- Chapter 18. Medical?Legal -- Chapter 19 The System -- Chapter 20. The Boards -- Chapter 21 The 80-Hour Week -- Chapter 22. Research -- Chapter 23. The Interview -- Chapter 24. HIPAA -- Chapter 25. Social Media -- Chapter 26. Electronic Medical Records -- Chapter 27. Insurance, Managed Care -- Chapter 28. Vacations -- Chapter 29. Finances -- Chapter 30. Assorted Affairs -- Chapter 31. The Transition?Part 2 -- Chapter 32. The Mentor?s Wrap-Up -- Chapter 33. Epilogue -- Appendix A. Commonly Used Web-Based Sites -- Appendix B. Books of Interest. .
  • Part 1. The Transition -- Attire -- The Little Black Book -- Communications -- Surgery Suite Etiquette -- The Clinics -- Rounds -- Difficult People -- Documentation -- Presentations -- The Mortality and Morbidity Conference -- The 80-Hour Week -- The Boards -- The Interview -- Medical - Legal -- HIPAA -- Assorted Affairs -- Part 2. The Transition -- The Mentor's Wrap-Up.
  • Portal hypertension: a history / Adrian Reuben and Roberto J. Groszmann -- Anatomy and vascular biology of the cells in the portal circulation / Massimo Pinzani and Francesco Vizzutti -- Cell and molecular mechanisms of increased intrahepatic resistance and hemodynamic correlates / Don C. Rockey -- Molecular mechanisms of systemic vasodilation and hyperdynamic circulatory state of cirrhosis / Richard Moreau and Didier Lebrec -- Mechanisms of sodium retention, ascites formation, and renal dysfunction in cirrhosis / Andrés Cárdenas and Pere Ginès -- Hepatic hemodynamics in portal hypertension: compliance, hepatic arterial buffer response, hepatorenal syndrome, and liver regeneration / W. Wayne Lautt and Zhi Ming --Neovascularization, angiogenesis and vascular remodeling in portal hypertension / Manuel Morales-Ruiz and Wladimiro Jiménez -- Mechanisms of cardiopulmonary hemodynamics and dysfunction in portal hypertension / Michael B. Fallon -- Measurement of hepatic venous pressure gradient: methods, interpretation, and pitfalls / G. Pomier-Layrargues and P. Michel Huet -- Evaluation of portal hemodynamics using indicator dilution and noninvasive techniques / Juerg Reichen -- Endoscopic assessment of portal hypertension including variceal pressure measurement: methods, interpretation and pitfalls / Angel Escorsell and Jaime Bosch -- Clinical features and natural history of variceal hemorrhage: implications for surveillance and screening / Juan G. Abraldes and Jaime Bosch -- Management strategies for the prophylaxis and treatment of esophageal variceal rupture: an overview / Roberto de Franchis -- Pharmacologic therapy for the management of esophageal varices: biology and utility of available agents / Norman D. Grace and Richard S. Tilson -- Endoscopic treatment for bleeding esophageal varices / John P. Cello -- Surgical therapies for management: surgical shunts and liver transplantation / J. Michael Henderson -- Transjugular intrahepatic portasystemic stent-shunt: technical considerations and clinical utility in the management of variceal hemorrhage / Dhiraj Tripathi ... [et al.] -- Clinical features and management of gastric varices, portal hypertensive gastropathy, and ectopic varices / Charmaine A. Stewart and Patrick S. Kamath -- Ascites: clinical features, diagnosis and natural history / Sakib Karim Khalid and Guadalupe Garcia-Tsao -- Management of ascites / Florence Wong -- Spontaneous bacterial peritonitis and other infections in cirrhosis / Rosa Maria Morillas and Ramon Planas -- Diagnosis and management of hepatorenal syndrome / Kevin Moore -- Pregnancy and portal hypertension / Bimaljit Sandhu and Arun J. Sanyal -- Causes and management of portal hypertension in the pediatric population / Frederick C. Ryckman, Maria H. Alonso and Greg Tiao -- Noncirrhotic portal hypertension and portal vein thrombosis / Shiv K. Sarin and Manav Wadhavan -- Hepatic venous outflow obstruction: Budd-Chiari syndrome and Veno-Occlusive disease / Hugo E. Vargas and Thomas D. Boyer -- Pulmonary complications associated with portal hypertension / Karen L. Swanson and Michael J. Krowka -- Health status assessment and economic analyses in cirrhosis and portal hypertension / Jayant A. Talwalkar and W. Ray Kim -- Future treatments: antifibrotic agents, nitric oxide donors, and gene therapy in the treatment of portal hypertension / Meena B. Bansal and Scott L. Friedman.
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  • This book provides clear guidance on the prevention, early diagnosis, and treatment of positional plagiocephaly. Information is first presented on classification, epidemiology, and etiopathogenesis. Diagnosis is then explained in detail, covering the significance of anamnestic data, physical examination, differential diagnosis, instrumental examinations, and anthropometric measurements. Preventive measures such as 'tummy time' and physiotherapy are described, and the role of orthoses, osteopathy, and surgery in treatment is closely examined. The closing chapter addresses prognosis and complications. Positional plagiocephaly is not only a "cosmetic" problem but can cause facial and mandibular asymmetry, visual disturbances, and cognitive and psychomotor impairment, yet when correctly treated it usually resolves by 6-7 years of age. This book will be an ideal aid for pediatricians, neurosurgeons,maxillo-facial surgeons, orthopedic physicians, physiotherapists, and for all involved in preventing and managing the condition.
  • Obstructive Sleep Apnea (OSA) is the most prevalent sleep disordered breathing disorder. It has become apparent that in more than half the patients with OSA, the frequency and duration of apneas are influenced by body position. To treat patients with Position Dependent OSA (POSA), positional therapy can be considered for preventing patients from sleeping in the worst sleeping position. Recently, treatment of POSA has advanced dramatically with the introduction of a new generation of positional therapy. Positional Therapy in Obstructive Sleep Apnea presents improved OSA diagnostic methods and the tools needed to implement positional therapy in clinical practice. This includes patient work-up, positional therapy with or without other treatments, consequences of guidelines, and future developments. Clinicians, students and researchers will find this comprehensive guide to be an invaluable resource for evaluating and treating sleep breathing disorders.
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  • An overview of prevention with people living with HIV / Richard J. Wolitski ... [et al.] -- HIV diagnosis and risk behavior / Lance S. Weinhardt -- HIV disclosure and safer sex / Jane M. Simoni, David W. Pantalone -- HIV-positive gay and bisexual men / Jeffrey T. Parsons -- HIV-positive and HCV-positive drug users / Steffanie A. Strathdee, Thomas L. Patterson -- Young people living with HIV / Amy Elkavich ... [et al.] -- Interventions in community settings / Lisa R. Metsch, Lauren K. Gooden, David W. Purcell -- Interventions in clinical settings / Susan M. Kiene, Jeffrey D. Fisher, William A. Fisher -- International perspectives / Jonathan Elford ... [et al.]
  • Walking with hope and dharma : are dogs enlightened? Are Humans? -- The costs and benefits of obliviousness : growing up in the 1950s -- Nine bad things that almost happened, and many more that did : getting to the other side of trauma -- What is the opposite of trauma? : the positive power of transformational grace -- Can there ever be enough me? : narcissism and the positive death of self -- What does it mean to live an "extraordinary life"?
  • Introduction to positive relationships: evidence-based practice across the world / Sue Roffey -- Wellbeing and resilience in young people and the role of positive relationships / Toni Noble and Helen McGrath -- Peaceful and compassionate futures: positive relationships as an antidote to violence / Robyn Hromek and Angela Walsh -- Learning about relationships / Gretchen Brion-Meisels and Stephanie M. Jones -- Positive couple relationships: the evidence for long-lasting relationship satisfaction and happiness / Vagdevi Meunier and Wayne Baker -- Positive parent-child relationships / Kimberly O'Brien and Jane Mosco -- Promoting positive outcomes for children experiencing change in family relationships / Emilia Dowling and Diana Elliott -- Friendships: the power of positive alliance / Karen Majors -- Developing positive relationships in schools / Sue Roffey -- Positive relationships at work / Sue Langley -- Positive professional relationships / Elizabeth Gillies -- Positive mentoring relationships: nurturing potential / Ann M. Brewer -- Spirited leadership: growing leaders for the future / Hilary B. Armstrong -- Positive community relations: border crossings and repositioning the "other" / Florence E. McCarthy and Margaret H. Vickers -- Positive relations between members of groups with divergent beliefs and cultures / Zalman Kastel -- Conflict and confrontation / Lois Edmund -- The repair and restoration of relationships / Peta Blood.
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    "A teenager's memoir of the experinces of bullying, being HIV positive and surviving the experiences to become a force for positive change in this world"-- Provided by publisher.
  • Positron emission tomography 2011
    Springer Protocols
    FDG-PET/CT in lymphoma / Malik E. Juweid -- FDG PET imaging of head and neck cancers / Yusuf Menda and Michael M. Graham -- Pet and PET-CT of lung cancer / Hans C. Steinert -- PET-CT in radiotherapy for lung cancer / Dirk De Ruysscher -- PET and PET-CT in esophageal and gastric cancer / Hinrich A. Wieder, Bernd J. Krause and Ken Herrmann -- FDG PET and PET/CT for colorectal cancer / Dominique Delbeke and William H. Martin -- Functional imaging of neuroendocrine tumors / Sofie Van Binnebeck, Wolfram Karges, and Felix M. Mottaghy -- Melanoma / Esther Bastiaannet, Harald J. Hoekstra, and Otto S. Hoekstra -- Breast cancer / Johannes Czernin, Matthias R. Benz, and Martin S. Allen-Auerbach -- Gynecological cancers / Norbert Avril, Sofia Gourtsoyianni, and Rodney Reznek -- Sarcoma / Sarah Ceyssens and Sigrid Stroobants -- PET and PET/CT in the management of thyroid cancer / Sandip Basu [and others] -- PET in testicular cancer / Alexander Becherer -- Pancreatic and hepatobiliary cancers / Andreas K. Buck [and others] -- Prostate cancer / Hossein Jadvar -- Brain tumors / Serge Goldman and Benoit J.M. Pirotte -- PET and PET/CT for unknown primary tumors / Thomas C. Kwee, Sandip Basu, and Abass Alavi -- Methodological aspects of multicenter studies with quantitative PET / Ronald Boellaard.
  • This handbook, written in a clear and precise style, describes the principles of positron emission tomography (PET) and provides detailed information on its application in clinical practice. The first part of the book explains the physical and biochemical basis for PET and covers such topics as instrumentation, image reconstruction, and the production and diagnostic properties of radiopharmaceuticals. The focus then turns to the use of PET in clinical practice, including its role in hybrid imaging (PET-CT). A wide range of oncological applications are discussed, including for cancers of the head and neck, breast, lung, digestive system, urinary tract, female reproductive system, and prostate, lymphoproliferative disorders, melanoma, and musculoskeletal tumors. Uses of PET in cardiology, neurology, and psychiatry are also addressed. Characteristic findings are described and illustrated by numerous images, many of them in color. This book will be of value not only for nuclear medicine physicians and radiologists but also for all oncologists, surgeons, cardiologists, neurologists, psychiatrists, and residents with an interest in molecular imaging.
  • This book provides basic information about the relatively new and evolving technology ?positron emission tomography- for its clinical applications and practical guidance for the referring physicians. Chapters cover application of PET in various clinical settings including oncology, cardiology, and neurology with a focus on its role in various cancers. Because most of the new PET equipments come as hybrid machines with CT or MRI, two chapters have been included at the end of the book to provide basic and comprehensive information about these two technologies. Molecular imaging is going to revolutionize the way we practice medicine in the future. It will lead to more accurate diagnosis of diseases and its extent which will lead to better management and better outcomes. PET imaging is mostly used in oncology, neurology and cardiology but also finds application in other situations such as infection imaging. The main focus, of course, is in management of cancer patients. PET (PET-CT) is not only very sensitive as it can detect changes in abnormal biochemical processes at cellular level but in one go all such areas can be detected in a whole body scan. It can show response to therapy, eradication of the disease or recurrence during the follow-up period. Some cancers, especially lymphoma or cancers of the head and neck, brain, lung, colon, or prostate, in very early stage may show up more clearly on a PET scan than on a CT scan or an MRI. A PET scan can also measure such vital functions as blood flow, oxygen use, and glucose metabolism, which can help to evaluate the effectiveness of a patient?s treatment plan, allowing the course of care to be adjusted if necessary. Apart from its vital role in oncology it can estimate brain's blood flow and metabolic activity. A PET scan can help finding various nervous system disorders, such as Alzheimer's disease, Parkinson's disease, multiple sclerosis, TIA etc. PET scan is also increasingly being used to find poor blood flow to the heart, which may mean coronary artery disease. It can most accurately estimate the extent of damage to the heart tissue especially after a heart attack and help choose the best treatment, such as coronary artery bypass graft surgery, stenting or medical treatment. PET scan can also contribute significantly in identifying areas exactly where radiotherapy is to be targeted avoiding unnecessary radiation exposure to surrounding tissue.
  • Positron Emission Tomography with Computed Tomography (PET/CT) is an accessible case book presenting interesting cases encountered by the author over the last ten years experience as the chairman and director of the only PET Center in the Philippines. It aims to guide physicians in the accurate interpretation of the PET scans of uncommon diseases, and sometimes common cases but in extraordinary situations or conditions. Encompassing a wide and varied range of fields such as oncology, inflammatory, immunology, anatomic variants etc., Positron Emission Tomography with Computed Tomography (PET/CT) will help those beginning their practice, and may even be useful to veterans of the field whose scope of practice has been limited to more common indications of an FDG-PET scan.
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    v. 1. Sect. A. Propedeutics in orthopedic diagnosis. Sect. B. Congenital deformities and disabilities -- v. 2. Sect. A. Paralytic disabilities. Sect. B. Static disabilities -- v. 3. Sect. A. Tuberculosis of the skeletal system. Sect. B. Osteomyelitis -- v. 4. Sect. A. Arthritis and diseases of muscle, bursae tendons and fasciae. Sect. B. Deficiency and degenerative diseases of the locomotor system.
  • Bioinformatics approaches for studying untranslated regions of mRNAs / Paramjeet S. Bagga -- Identification of mRNA polyadenylation sites in genomes using cDNA sequences, expressed sequence tags, and trace / Ju Youn Lee, Ji Yeon Park, and Bin Tian -- Bioinformatic tools for studying post-transcriptional gene regulation : the UAlbany TUTR Collection and other informatic resources / Francis Doyle ... [et al.] -- In-line probing analysis of riboswitches / Elizabeth E. Regulski and Ronald R. Breaker -- Ribotrap : targeted purification of RNA-specific RNPs from cell lysates through immunoaffinity precipitation to identify regulatory proteins and RNAs / Dale L. Beach and Jack D. Keene -- Advances in RIP-chip analysis : RNA-binding protein immunoprecipitation-microarray profiling / Timothy E. Baroni ... [et al.] -- Biosensors for RNA aptamers-protein interaction / Sara Tombelli, Maria Minunni, and Marco Mascini -- A tethering approach to study proteins that activate mRNA turnover in human cells / Sandra L. Clement and Jens Lykke-Andersen -- RNA analysis by biosynthetic tagging using a 4-thiouracil and uracil phosphoribosyltransferase / Gusti M. Zeiner ... [et al.] -- Efficient 5' cap-dependent RNA purification : use in identifying and studying subsets of RNA / Edyta Z. Bajak and Curt H. Hagedorn -- Enrichment of alternatively spliced isoforms / Julian P. Venables -- In vivo methods to assess polyadenylation efficiency / Lisa K. Hague, Tyra Hall-Pogar, and Carol S. Lutz -- Monitoring the temporal and spatial distribution of RNA in living yeast cells / Roy M. Long and Carl R. Urbinati -- Analysis of mRNA partitioning between the cytosol and endoplasmic reticulum compartments of mammalian cells / Samuel B. Stephens ... [et al.] -- In vivo and in vitro analysis of poly(A) length effects on mRNA translation / Jing Peng, Elizabeth L. Murray, and Daniel R. Schoenberg -- A ribosomal density-mapping procedure to explore ribosome positions along translating mRNAs / Naama Eldad and Yoav Arava -- Identification of changes in gene expression by quantitation of mRNA levels / Wendy M. Olivas -- Application of the Invader® RNA assay to the polarity of vertebrate mRNA decay / Elizabeth L. Murray and Daniel R. Schoenberg -- Development of an in vitro mRNA decay system in insect cells / Kevin Sokoloski, John R. Anderson, and Jeffrey Wilusz -- Using synthetic precursor and inhibitor miRNAs to understand miRNA function / Lance P. Ford and Angie Cheng -- A step-by-step procedure to analyze the efficacy of siRNA using real-time PCR / Angie Cheng, Charles L. Johnson, and Lance P. Ford.
  • STAR trek: an introduction to STAR family proteins and review of quaking (QKI) / Karen Artzt and Jiang I. Wu -- The STAR family member: QKI and cell signaling / Yue Feng and Andrew Bankston -- Insights into the structural basis of RNA : recognition by STAR domain proteins / Sean P. Ryder and Francesca Massi -- Post-translational regulation of STAR proteins and effects on their biological functions / Claudio Sette -- Expression and fuctions of the STAR proteins Sam68 and T-STAR in mammalian spermatogenesis / Ingrid Ehrmann and David J. Elliott -- The role of quaking in mammalian embryonic development / Monica J. Justice and Karen K. Hirschi -- Drosophila STAR proteins: what can be learned from flies? / Talila Volk -- C. elegans STAR proteins, GLD-1 and ASD-2, regulate specific RNA targets to control development / Min-Ho Lee and Tim Schedl -- The branchpoint binding protein: in and out of the spliceosome cycle / Brian C. Rymond -- Reaching for the STARs: linking RNA binding proteins to diseases / Stéphane Richard.
  • (Publisher-supplied data) Post-translational modifications serve many different purposes in several cellular processes such as gene expression, protein folding and transport to appropriate cell compartment, protein-lipid and protein-protein interactions, enzyme regulation, signal transduction, cell proliferation and differentiation, protein stability, recycling and degradation. Although several-hundred different modifications are known, the significance of many of them remains unknown. The enormous versatility of the modifications which frequently alter the physico-chemical properties of the respective proteins represents an extraordinary challenge in understanding their physiological role. Since essential cellular functions are regulated by protein modifications, an improvement of current understanding of their meaning might allow new avenues to prevent and/or alleviate human and animal diseases.
  • Disulfide bond mapping by cyanylation-induced cleavage and mass spectrometry / Jiang Wu -- Detection of post-translational modifications by fluorescent staining of two-dimensional gels / Archana M. Jacob and Chris W. Turck -- Identification of protein phosphorylation sites by advanced LC-ESI-MS/Ms methods / Christoph Weise and Christof Lenz -- Analysis of tyrosine-O-sulfation / Jens R. Bundegaard ... [et al.] -- [alpha]-amidated peptides : approaches for analysis / Gregory P. Mueller and William J. Driscoll -- [gamma]-glutamate and [beta]-hydroxyaspartate in proteins / Francis J. Castellino, Victoria A. Ploplis, and Li Zhang -- Lysine hydroxylation and cross-linking of collagen / Mitsuo Yamauchi and Masashi Shiiba -- Mass spectrometric determination of protein ubiquitination / Carol E. Parker ... [et al.] -- Analysis of sumoylation / Andrea Pichler -- Detection and analysis of protein ISGylation / Tomoharu Takeuchi and Hideyoshi Yokosawa -- Analysis of methylation, acetylation, and other modifications in bacterial ribosomal proteins / Randy J. Arnold, William Running, and James P. Reilly -- Analysis of S-acytlation of proteins / Michael Veit, Evgeni Ponimaskin, and Michael F.G. Schmidt -- Metabolic labeling and structural analysis of glycosylphosphatidylinositols from parasitic protozoa / Nahid Azzouz, Peter Gerol, and Ralph T. Schwarz -- 2-dimensional electrophoresis : detection of glycosylation and influence on spot pattern / Klemens Löster and Christoph Kannicht -- Carbohydrate composition analysis of glycoproteins by HPLC using highly fluorescent anthanilic acid (AA) tag / George N. Saddic, Shirish T. Dhume, and Kalyan R. Anumula -- Enzymatical hydrolysis of N-glycans from glycoproteins and fluorescent labeling by 2-aminobenzamide (2-AB) / Rolf Nuck -- Separation of N-glycans by HPLC / Martin Gohlke and Véronique Blanchard -- Enzymatic sequence analysis of N-glycans by exoglycosidase cleavage and mass spectrometry--detection of Lewis X structures / Christoph Kannicht, Detlef Grunow, and Lothar Lucka -- Immunochemical methods for the rapid screening of the O-glycosidically linked N-acetylglucosamine modification of proteins / Michael Ahrend ... [et al.] -- Analysis of O-glycosylation / Juan J. Calvete and Libia Sanz -- Characterization of site-specific N-glycosylation / Katalin F. Medzihradszky -- Monitoring glycosylation of therapeutic glycoproteins for consistency by HPLC using highly fluorescent anthranilic acid (AA) tag / Shirish T. Dhume, George N. Saddic, and Kalyan R. Anumula -- Comparability and monitoring immunogenic N-linked oligosaccharides from recombinant monoclonal antibodies from two different cell lines using HPLC with fluorescence detection and mass spectrometry / Bruce R.. Kilgore ... [et al.] -- Mass spectrometry and HPLC with fluorescent detection-based orthogonal approaches to characterize N-linked oligosaccharides of recombinant monoclonal antibodies / Adam W. Lucka ... [et al.] -- Web-based computational tools for the prediction and analysis of post-translational modifications of proteins / Vladimir A. Ivanisenko, Dmitry A. Afonnikov, and Nikolay A. Kolchanov.
  • Introduction / Vikas R. Dharnidharka, Michael Green and Steven Webber -- Historical Perspective on the Early Studies of Posttransplant Lymphoproliferative Disorders (PTLD) / Douglas W. Hanto -- Epidemiology of PTLD / Vikas R. Dharnidharka -- The Biology of Epstein-Barr Virus and Posttransplant Lymphoproliferative Disease / Olivia M. Martinez -- Epstein-Barr Viral Load Testing: Role in the Prevention, Diagnosis and Management of Posttransplant Lymphoproliferative Disorders / Jutta K. Preiksaitis -- Clinical Features and Diagnostic Evaluation of Posttransplant Lymphoproliferative Disorder / Upton D. Allen -- Pathology / Steven H. Swerdlow -- Prognostic Factors for PTLD / Tapan Maniar and Donald Tsai -- Treatment of PTLD / Steven A. Webber -- Prevention of Epstein-Barr Virus Infection and Posttransplant Lymphoproliferative Disease Following Transplantation / Michael Green and Marian Michaels -- Organ Specific Issues of PTLD - Kidney / Sophie Caillard -- Posttransplantation Lymphoproliferative Disorder (PTLD) in Liver and Small Bowel Transplant Recipients / Jaime Pineda and George V. Mazariegos -- Heart and Lung Transplantation / Silke Wiesmayr and Steven A. Webber -- Posttransplant Lymphoproliferative Disease (PTLD) in Hematopoietic Stem Cell Transplantation (HSCT) / Thomas G. Gross -- Research Priorities and Future Directions / Vikas R. Dharnidharka, Michael Green and Steven A. Webber.
  • Bringing together the most up-to-date research on post-traumatic arthritis (PTA) and its management, this book is a comprehensive presentation of the current thinking on all aspects of the mechanisms of joint injury and subsequent development of PTA. Divided into thematic sections, it includes discussions of the incidence and burden of PTA, both in society at large and in the military population specifically; the relevant experimental work on PTA, from basic science to animal models; peri-articular tissue responses to of joint injury and potential mechanisms of PTA; the current clinical assessment and treatment of common joint injuries leading to PTA; and emerging technologies and treatments for PTA, including biomarkers and stem cell therapies. Taken together, it will be an invaluable resource for orthopedic surgeons, rheumatologists and other joint injury researchers and clinicians.
  • Post-traumatic stress disorder: definition, prevalence, and risk factors / Terence M. Keane, Brian P. Marx, and Denise M. Sloan -- The amygdala and the neural pathways of fear / Jacek Dębiec and Joseph LeDoux -- Physiology of the amygdala: implications for PTSD / Donald G. Rainnie and Kerry J. Ressler -- Counteracting molecular pathways regulating the reduction of fear: implications for the treatment of anxiety diseases / Andre Fischer and Li-Huei Tsai -- Memory in PTSD: a neurocognitive approach / Mieke Verfaellie and Jennifer J. Vasterling -- Toward animal models of post-traumatic stress disorder / Hagit Cohen and Gal Richter-Levin -- PTSD: from neurons to networks / Rajnish P. Rao ... [et al.] -- Arousal neurons in the brain / Priyattam J. Shiromani and Carlos Blanco-Centurion -- Hyperarousal and post-traumatic stress disorder: a role for the hypocretin system / Matt Carter and Luis de Lecea -- The locus coeruleus-noradrenergic system and stress: implications for post-traumatic stress disorder / Craig W. Berridge -- Effect of stress on sleep and its relationship to post-traumatic stress disorder / L.D. Sanford and X. Tang -- Stress hormones and PTSD / Rachel Yehuda -- Low basal cortisol and startle responding as possible biomarkers of PTSD: the influence of internalizing and externalizing comorbidity / Mark W. Miller, Erika J. Wolf, Laura Fabricant, and Nathan Stein -- Functional neuroimaging in post-traumatic stress disorder / Israel Liberzon and Sarah N. Garfinkel -- The amygdala in post-traumatic stress disorder / Lisa M. Shin -- Pharmacologic treatment of PTSD / Murray A. Raskind -- Guided imagery as a therapeutic tool in post-traumatic stress disorder / Jennifer L. Strauss, Patrick S. Calhoun, and Christine E. Marx -- Virtual reality exposure therapy for combat-related PTSD / Albert Rizzo ... [et al.].
  • This book provides a comprehensive review of the imaging features that are seen following the application of a variety of ophthalmic and orbital procedures and therapies in patients with disorders affecting the cornea, retina, lens and ocular adnexa, as well as glaucoma. A wealth of high-quality radiographic images, including CT, MRI and ultrasound, depict expected post-treatment findings and appearances in patients with complications. In addition, correlations are made with clinical photographs and photographs of implanted devices. This reference has been prepared by experts in the field and should serve as a valuable guide to both radiologists and ophthalmologists, facilitating navigation of the intricacies of the treated eye and orbit and optimization of patient management.
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  • Now in a revised and expanded second edition including ten new chapters, this classic text on the diagnosis and management of posterior cruciate ligament injuries represents the state of the art. Comprehensive and used-friendly, the book covers PCL anatomy and biomechanics, diagnosis and evaluation, and both surgical and non-surgical treatment strategies. Surgical chapters discuss graft selection and open and arthroscopic techniques, including both primary and revision surgery and combined reconstruction with other knee ligaments. New chapters illustrate cutting-edge and advanced surgical techniques in reconstruction and primary repair, articular cartilage resurfacing and meniscus transplant in the PCL injured knee, mechanical graft tensioning, the role of osteotomy, treatment of PCL injuries in children, results of treatment and outcomes data in PCL injuries, clinical case studies, and the editorℓ́ℓs experience chapter based on 24 years of treating PCL injuries. Complications, bracing and rehabilitation round out the presentation. Written and edited by leaders in the management of injuries to the knee, this will be an invaluable text for orthopedic surgeons and sports medicine practitioners alike.
  • The objective of The Posterior Intrahepatic Approach in Liver Surgery is to describe techniques, as the more routine application today of split liver, living donor transplantation has continued to teach us more about the anatomy of the liver and its applications. Furthermore, laparoscopic surgery in general has grown space and it is important to show the application of the posterior approach in laparoscopic liver surgery as well.
  • Anatomy and physiology of the pelvic digestive organs / Ursula Szmulowicz -- Common tests for evaluating the posterior pelvic floor / Miles R. Joyce and Brooke Gurland -- Evaluation and treatment of fecal incontinence / Massarat Zutshi -- Anorectovaginal fistula / Tracy L. Hull -- Difficult evacuation / Brooke Gurland, Ziad Kutayli, and Marie Fidela R. Paraiso -- Surgical treatment of rectal prolapse in adults / Myles R. Joyce and James S. Wu -- Sacral neuromodulation for posterior pelvic floor abnormalities : new clinical indications / Janelle Evans and Mickey Karram -- The pelvic floor center : a multidisciplinary approach to pelvic floor dysfunction / Janelle Evans and Bradley Davis.
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  • Introduction to postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Specimen selection, collection, preservation, and security / Bradford R. Hepler and Daniel S. Isenschmid -- Common methods in postmortem toxicology / W. Lee Hearn and H. Chip Walls -- Strategies for postmortem toxicology investigation / edited and revised by Henrik Druid -- Quality assurance in postmortem toxicology / Wilmo Andollo -- Interpretation of postmortem drug levels / Graham R. Jones.
  • Cardiac surgical procedures are among the most common and most complicated forms of surgery worldwide and the postoperative period is characterized by complex challenges. Among the factors determining ultimate clinical outcome, postoperative critical care is of major importance. This book adopts a clinical approach in explaining and analyzing the course of clinical care in patients undergoing cardiac surgery. Since the postoperative clinical status is directly influenced by preoperative and intraoperative factors, the early chapters briefly examine preoperative issues and the intraoperative course of cardiac surgery, with particular attention to anesthesia and the process of cardiopulmonary bypass. Subsequent chapters primarily address the critical care of patients by means of an organ-oriented approach, which will enable the reader to use the text as a "cookbook" of cardiac intensive care. This book is intended for use in daily practice by cardiac surgeons, cardiac anesthesiologists, intensivists and cardiac intensive care nurses.
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  • Sperm proteases and extracellular ubiquitin-proteasome system involved in fertilization of ascidians and sea urchins -- ISGylation: a conserved pathway in mammalian pregnancy -- Src-family tyrosine kinases in oogenesis, oocyte maturation and fertilization: an evolutionary perspective -- Posttranslationally modified tubulins and other cytoskeletal proteins: their role in gametogenesis, oocyte maturation, fertilization and pre-implantation embryo development -- Deubiquitinating enzymes in oocyte maturation, fertilization and preimplantation embryo development -- Posttranslational modifications of zona pellucida proteins -- Role of aberrant protein modification, assembly, and localization in cloned embryo phenotypes -- Role of posttranslational protein modifications in epididymal sperm maturation and extracellular quality control -- Ubiquitin-proteasome system in spermatogenesis -- Role of posttranslational modifications in C. elegans and Ascaris spermatogenesis and sperm function.
  • A handy, easy-to-read reference for the diag- nosis and treatment of posttraumatic and acute stress disorders,℗ℓ this important 6th ℗ℓedition has been revised and updated exten- sively, offering a wealth of new information in a concise format. The new DSM-5 diagnos- tic criteria for PTSD and ASD are discussed in depth. Updated tables listing instruments for assessing diagnosis and symptom severity are presented.℗ℓ℗ℓ Chapters 3-5 have been revised to keep pace with the ever-expanding literature on treatment of PTSD with specific attention to evidence-based cognitive-behavioral therapy, ℗ℓCBT, and other individual psychosocial treatments (e.g. eye movement desensitization and reprocessing, EMDR) as well as℗ℓ the growing literature on couples, family, group and school-based treatments. Chapter ℗ℓ5 reviews the pathophysiology of PTSD and evidence-based pharmacotherapy for the disorder.℗ℓ Chapter 6 then addresses both normal acute stress ℗ℓreactions and clinically significant ASD,℗ℓ as well as ℗ℓeffective interventions for each. In short this comprehensive, sophisticated, practical, guide is designed for all practitioners who wish to provide the best treatment for PTSD and ASD.
  • Understanding psychological trauma and posttraumatic stress disorder (PTSD) -- The impact of psychological trauma -- Etiology of traumatic stress disorders -- Epidemiology of psychological trauma and traumatic stress disorders -- Neurobiology of traumatic stress disorders and their impact -- Assessment of psychological trauma and traumatic stress disorders -- Treatment of adults with traumatic stress disorders -- Treatment of children and adolescents with traumatic stress diseases -- Prevention of traumatic stress disorders -- Forensic issues in the traumatic stress field -- Social, cultural and ethical issues in the traumatic stress field -- Careers and ethical issues in the traumatic stress field.
  • Identifying transcriptional regulatory regions using reporter genes and DNA-protein interactions by chromatin immunoprecipitation / Lezanne Ooi and Ian C. Wood -- Quantitative RT-PCR methods for investigation of low copy potassium channel gene expresssion in native murine arteries / Alex Cheong, Samuel J. Fountain, and David J. Beech -- Cloning of potassium chanel splice variants from tissues and cells / Lie Chen and Michael J. Shipston -- Chemiluminescence assays to investigate membrane expression and clathrin-mediated endocytosis of KATP channels / Andrew J. Smith and Asipu Sivaprasadarao -- Investigation of KATP channel endocytosis by immunofluorescence / Andrew J. Smith and Asipu Sivaprasadarao -- Investigation of KATP channel endocytosis and cell surface density by biotinylation and western blotting / Andrew J. Smith and Asipu Sivaprasadarao -- Lipid microdomains and K+ channel compartmentation : detergent and non-detergent-based methods for the isolation and characterisation of cholesterol-enriched lipid rafts / Laura J. Sampson and Caroline Dart -- Determination of phosphoinositide binding to K+ channel subunits using a protein-lipid overlay assay / Alison M. Thomas and Andrew Tinker -- Protein complex analysis of native brain potassium channels by proteomics / Guillaume Sandoz and Florian Lesage -- Xenopus oocytes as a heterologous expression system for studying ion channels with the patch-clamp technique / Paolo Tammaro, Kenju Shimomura, and Peter Proks -- Whole-cell recording using the perforated patch clamp technique / Jonathan D. Lippiat -- Recording the activity of ATP-sensitive K+ channels in open-cell cell-attached configuration / Andrei I. Tarasov -- Planar patch clamp : advances in electrophysiology / Andrea Brüggemann ... [et al.] -- Analysing steroid modulation of BKCa channels reconstituted into planar lipid bilayers / Heidi de Wet, Jonathan D. Lippiat, and Marcus Allen -- Using bioluminescence resonance energy transfer to measure ion channel assembly / Gina M. Whitaker and Eric A. Accili -- The use of FRET microscopy to elucidate steady state channel conformational rearrangements and G protein interaction with the GIRK channels / Adi Raveh, Inbal Riven, and Eitan Reuveny -- The voltage-clamp fluorometry technique / Chris S. Gandhi and Riccardo Olcese -- Identification of mutations in the Kir6.2 subunit of the KATP channel / Sarah E. Flanagan and Sian Ellard -- Modulation of potassium ion channel proteins utilising antibodies / Mark L. Dallas, Susan A. Deuchars, and Jim Deuchars -- Fluorescence-based Tl+-influx assays as a novel approach for characterization of small-conductance CA²⁺-activated K+ channel modulators / Susanne Jørgensen, Tina H. Johansen, and Tino Dyhring -- Rubidium efflux as a tool for the pharmacological characterisation of compounds with BK channel opening properties / Neil G. McKay, Robert W. Kirby, and Kim Lawson -- Recording hERG potassium currents and assessing the effects of compounds using the whole-cell patch-clamp technique / Ray M. Helliwell.
  • The conceptual underpinnings of statistical power -- Strategies for increasing statistical power -- General guidelines for conducting a power analysis -- The t-test for independent samples -- The paired t-test -- One-way between subjects analysis of variance -- One-way between subjects analysis of covariance -- One-way repeated measures analysis of variance -- Interaction effects for factorial analysis of variance -- Power analysis for more complex designs -- Other power analytic issues and resources for addressing them.
  • Poxviruses 2007
  • "Practical Ambulatory Anesthesia covers all aspects of sedation, anesthesia, and pain relief for patients undergoing day (ambulatory) surgery. Written and edited by leading clinical anesthesiologists from the USA and Europe, it provides clear guidance on how to handle particular patients in particular situations. Comprehensive in scope, each chapter summarizes major studies and review papers, followed by practical advice based on the authors' and editors' clinical and scientific expertise. This combination of authoritative evidence-based guidance and personal advice ensures the reader benefits from the latest scientific knowledge and the authors' wealth of experience. Chapters discuss how to plan, equip and staff an ambulatory unit, pharmacology, key concepts of ambulatory care, pre- and post-operative issues, quality assurance, and current controversies. There are also dedicated chapters for topics including regional anesthesia for ambulatory surgery and pediatric ambulatory anesthesia. This text provides a much-needed comprehensive and evidence-based guide for clinical anesthesiologists"-- Provided by publisher. "Our goal with this book is to provide an up-to-date, practical guide for the practitioners of ambulatory anesthesia. Ambulatory anesthesia incorporates most anesthetic topics and knowledge, but the focus is shifted somewhat from looking solely at what happens in the operating room to encompassing the complete perioperative period. Although safety and quality in the operating room remain major goals, the ambulatory anesthesia provider should also plan to optimize the postoperative period"-- Provided by publisher.
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    Anesthetic management of cardiac transplantation / Zachariah Thomas, Anne L. Rother, and Charles D. Collard -- Arrhythmia, rhythm management devices, and catheter and surgical ablation / Jerry C. Luck -- Coagulation management during and after cardiopulmonary bypass / Linda Shore-Lesserson, Jay C. Horrow, and Glenn P. Gravlee -- Surgical ventricular restoration and remodeling / Benjamin C. Sun and Glenn P. Gravlee -- Cardiopulmonary bypass circuits: design and use / Alfred H. Stammers ... [et al.] -- Pathophysiology of cardiopulmonary bypass / Eugene A. Hessel, II and Joseph N. Ghansah -- Devices for cardiac support and replacement / Benjamin C. Sun, Ronald Harter, and Glenn P. Gravlee -- Intraoperative myocardial protection / John W. C. Entwistle, III and Andrew S. Wechsler -- Protection of the brain during cardiac surgery / John M. Murkin and Ivan Iglesias -- Anesthetic management for thoracic aortic aneurysms and dissections / Amanda A. Fox and John R. Cooper, Jr. -- Anesthetic management for surgery of the lungs and mediastinum / Peter Slinger and Erin A. Sullivan -- Pain management for cardiothoracic procedures / Mark Stafford-Smith and Thomas M. McLoughlin, Jr. The cardiac surgical patient / Donald E. Martin and Charles E. Chambers -- Cardiovascular drugs / Jeffrey R. Balser, John F. Butterworth, and David R. Larach -- Monitoring the cardiac surgical patient / Mark A. Gerhardt and Thomas M. Skeehan -- Transesophageal echocardiography / Jack S. Shanewise -- Induction of anesthesia / Michael B. Howie and Glenn P. Gravlee -- Anesthetic management in the precardiopulmonary bypass period / Anand R. Mehta, Mark E. Romanoff, and Michael G. Licina -- Anesthestic management during cardiopulmonary bypass / Neville M. Gibbs and David R. Larach -- The postcardiopulmonary bypass period: weaning to ICU transport / Mark E. Romanoff and Roger L. Royster -- Postoperative care of the cardiac surgical patient / Mark A. Gerhardt -- Anesthetic management of myocardial revascularization / Gary Okum and Jay C. Harrow -- Anesthetic management for the surgical treatment of valvular heart disease / Mikhail R. Sukernik and Donald E. Martin -- Alternative approaches to cardiac surgery with and without cardiopulmonary bypass / James Ramsay, Michael G. Licina, and Anand R. Mehta -- Anesthetic management for patients with congenital heart disease / Laurie K. Davies and Daniel G. Knauf --
  • Section I. Preventive Cardiology -- Chapter 1. Prevention of Cardiovascular Disease / Maulik Shah and Reza Ardehali -- Chapter 2. Dyslipidemia / Karim Sallam and Reza Ardehali -- Chapter 3. Hypertension / Christopher Woods and Richard Lafayette -- Section II. Coronary Artery Disease -- Chapter 4. Stable Angina / Joshua Lehrer and William F. Fearon -- Chapter 5. Unstable Angina and Non-ST Elevation Myocardial Infarction / Joshua Lehrer and David P. Lee -- Chapter 6. ST-Elevation Myocardial Infarction / Yen Tibayan -- Section III. Heart Failure -- Chapter 7. Care of the Cardiomyopathic Patient / Nicholas J. Leeper, Reza Ardehali and Michael Fowler -- Chapter 8. Pulmonary Hypertension and Right Heart Failure / Matthew T. Wheeler and Roham T. Zamanian -- Chapter 9. Heart Transplantation / Jesus Almendral, Robert Maranda and Sharon Hunt -- Section IV. Valvular and Vascular Disease -- Chapter 10. Valvular Heart Disease / Reza Ardehali and Ingela Schnittger -- Chapter 11. Diseases of the Aorta / Michael Ho and David Liang -- Chapter 12. Peripheral Vascular Disease / Andrew Wilson, Reza Ardehali and John Cooke -- Section V. Arrhythmias and Sudden Cardiac Death -- Chapter 13. Atrial Fibrillation and Flutter / Marco Perez and Amin Al-Ahmad -- Chapter 14. Supraventricular Tachycardia / Marco Perez and Paul Zei -- Chapter 15. Ventricular Tachycardia / Jeffrey Hsing and Henry Hsia -- Chapter 16. Bradycardia / Jeffrey Hsing and Paul Wang -- -- Chapter 17. Syncope / Farheen Shirazi and Karen Friday -- Section VI. Cardiovascular Disease in Special Populations -- Chapter 18. Congenital Heart Disease / Patrick Yue -- Chapter 19. Cardiology Consultation and Management of Perioperative Complications / Azar Mehdizadeh and Stanley G. Rockson -- Chapter 20. Management of Pre- and Post-Cardiac Surgery Patients / Mohammad Haghdoost and Ramin Beygui -- Section VII. Specialized Testing and Therapeutics -- Chapter 21. Adult Advanced Cardiac Life Support / Anurag Gupta and Amin Al-Ahmad -- Chapter 22. ECG Interpretation / Marco Perez and Victor F. Froelicher -- Chapter 23. Transthoracic and Transesophageal Echocardiography / Shahriar Heidary and Ingela Schnittger -- Chapter 24. Noninvasive Stress Testing / Arvindh Kanagasundram and Victor F. Froelicher -- Chapter 25. Cardiac MRI and CT / Chandra Katikireddy and Michael V. McConnell -- Chapter 26. Clinical Cardiac Hemodynamics / Shirley Park and Euan Ashley -- Chapter 27. Percutaneous Interventions / Aiden O'Loughlin and Alan Yeung -- Chapter 28. Pacemakers and ICD Troubleshooting / Marco Perez and Paul Wang -- Chapter 29. Introduction to Electrophysiology Studies / Ronald Lo and Henry Hsia.
  • "Practical Approach to Electroencephalography presents just enough detail, plus answers to common questions and problems - bringing even beginning readers to a highly sophisticated level of EEG interpretation. This guide goes beyond the basics of EEG interpretation, with and easy-to-understand explanation of the behaviour and electronics of EEG filters. Proper EEG terminology is explained and precisely defined. Abundant EEG examples throughout help you to recognize normal and abnormal EEGs in all situations."--BOOK JACKET.
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    Local anesthetics / Christopher M. Bernards -- Local anesthetic clinical pharmacology / Christopher M. Bernards -- Complications of regional anesthesia / Christopher M. Bernards -- Premedication and monitoring / Michael F. Mulroy -- Equipment / Michael F. Mulroy -- Spinal anesthesia / Francis V. Salinas -- Epidural anesthesia / Christopher M. Bernards -- Caudal anesthesia / Michael F. Mulroy -- Intercostal and terminal nerve anesthesia of the trunk / Michael F. Mulroy -- Paravertebral block / Christopher M. Bernards -- Sympathetic blockade / Christopher M. Bernards -- Brachial plexus blocks / Susan B. McDonald -- Intravenous regional anesthesia / Susan B. McDonald -- Peripheral nerve blocks of the upper extremity / Susan B. McDonald -- Lumbar plexus blocks / Francis V. Salinas -- Sacral plexus-sciatic nerve blocks / Francis V. Salinas -- Airway / Michael F. Mulroy -- Head and face / Christopher M. Bernards -- Cervical plexus blocks / Michael F. Mulroy -- Ophthalmic anesthesia / Susan B. McDonald -- Pediatric regional anesthesia / Kathleen L. Larkin -- Ambulatory surgery / Michael F. Mulroy -- Postoperative pain management / Susan B. McDonald.
  • Phlebology: History and Epidemiology -- Setting Up Sclerotherapy in a Phlebology Practice -- Venous Anatomy of the Lower Extremity -- Pathophysiology of Venous Disease -- Clinical Evaluation of Patients with Chronic Lower Extremity Venous Disorder -- Venous Duplex Ultrasound in Patients with Chronic Venous Disorders -- Elimination of Truncal Vein Reflux: Surgery, Thermal Ablation, and Chemical Ablation for Chronic Venous Disorders -- Sclerotherapy and Alternatives -- Foam Sclerotherapy -- Ambulatory Phlebectomy -- Treatment of Incompetent Perforating Veins -- Tributary Treatment Strategies: Treatment of Varicose Veins -- Genetic Thrombophilias: When to Consider and What to Do -- Deep Vein Thrombosis: What to Do -- Superficial Vein Thrombosis -- Treatment of Hand Veins -- Compression Therapy.
  • Acknowledgements -- Preface -- Overview of headache in the emergency department -- Getting started -- Secondary headaches -- General treatment strategies -- Treating the child and adolescent with acute headache -- Treatment of pregnant and breastfeeding patients with acute headache in the ED -- Treatment of the older adult patient (>50 years old) with acute headache in the ED -- Managing risk in the ED -- After the ED: arranging post-ED follow-up care.
  • Chapter 1. Bacterial Communities by Location and Function -- Chapter 2. Common Bacteriologically Initiated Events -- Chapter 3. Bacteria Are Everywhere -- Chapter 4. Preliminary Differentiation of Alpha Bacterial Consorms -- Chapter 5. Environmental Dynamics of Bacterial Consorms -- Chapter 6. Bacterial Consormial Challenges -- Chapter 7. Detailed Identification of Bacterial Consorms -- Chapter 8. Biochemical Methods for Identification of Consorms -- Chapter 9. Identifying Bacterial Consorms Using BART -- Chapter 10. Introduction to Grid-Formatted Bacteriological Atlas -- Chapter 11. Defining Bacterial Consorms in Gridded Atlas Format -- Chapter 12. Natural Bacteriological Consorms.
  • 1. Introductory concepts -- 2. Single channel (univariate) signal -- 3. Multiple channels (multivariate) signals -- 4. Application to biomedical signals.
  • Pt.1. Introduction -- Pt.2. Observational Studies -- Pt.3. Step-by-Step Biostatistics of a Clinical Trial -- Pt.4. Additional Concepts in Biostatistics.
  • Breast anatomy / Jonathan M. Kitayama and Teri A. Longacre -- Specimen processing / Christina S. Kong and Kristin C. Jensen -- Basic breast radiology / Brandi Tamara Nicholson -- Surgical approaches to breast lesions / David R. Brenin and Anneke T. Schroen -- Juvenile breast lesions / Florette K. Gray Hazard and Gerald J. Berry -- Fibrosing lesions (diabetic mastopathy/sclerosing adenosis/radial scar/atypical apocrine adenosis/PASH) / Mary Galgano and Kristen Atkins -- Stromal lesions/sarcomas (hamartomas, periductal stromal tumors, vascular lesions, phyllodes, de novo sarcomas) / Jesse K. McKenney and Richard L. Kempson -- Intraductular and intralobular proliferations / Kristen A. Atkins -- Invasive breast carcinomas / Yan Peng, Christina S. Kong and Yunn-Yi Chen -- Cutaneous/adnexal tumors / Catherine Barry and James Patterson -- Sentinel lymph nodes / William M. Rogers and Teri A. Longacre -- Fine needle aspiration biopsy of the breast / Amy Ly and Christina S. Kong -- Special studies / Kristin C. Jensen and Matt van de Rijn.
  • This inclusive work presents a comprehensive update on vaccines for the international traveller. In over 21 chapters, written by leading writers in travel medicine from Australia, New Zealand and Singapore, vaccinology for travel is explained in accessible terms with a focus on practical information. An initial introduction to immunology proceeds into common travel-related diseases, and a risk-analysis for acquiring them, followed by vaccine administration techniques and examples of how this knowledge can be applied to the traveller with special risks including children, pregnant women and mass travel. The book also provides a summary of current clinical practice with respect to travel medicine in Australia, New Zealand and Singapore. This straightforward guide to the administration of vaccines for travellers is intended to be the one-stop for the primary healthcare professional needing authoritative practical information speedily. In addition to basic knowledge in vaccinology, guides are offered as to appropriate vaccine recommendations for travel to global regions together with vaccine contents in order to identify any precautions and contraindications. This text presents assessment and management guidelines for common medical presentations to the travel health professional in primary-care health. Easy reference chapters, with practical management parameters for vaccination for travellers, will confidently guide any knowledge acquired permitting self-responsibility in vaccine-preventable disease prevention.
  • Practical Controversies in Medical Management of Stone Disease addresses areas of controversy regarding the evaluation and management of recurrent stone formers and provides the best available evidence to support or refute common drug and dietary recommendations. Aimed at dispelling common myths about preventative stone treatment, this book provides practical recommendations for the diagnostic evaluation and treatment of recurrent calcium stone formers, and addresses uric acid and cystine stone formers. Written by experts in stone disease, Practical Controversies in Medical Management of Stone Disease is a concise yet comprehensive resource that provides the best, current evidence supporting medical practices regarding kidney stone prevention. The book will be of value to anyone involved in the medical care of patients with kidney stones, including urologists, nephrologists, primary care physicians, and dieticians.
  • Practical data mining 2012
    What is data mining and what can it do? -- The data mining process -- Problem definition (Step 1) -- Data evaluation (Step 2) -- Feature extraction and enhancement (Step 3) -- Prototyping plan and model development (Step 4) -- Model evaluation (Step 5) -- Implementation (Step 6) -- Supervised learning Genre section 1 - Detecting and characterizing known patterns -- Forensic analysis Genre Section 2 -Detecting, characterizing, and exploiting hidden patterns -- Genre Section 3 - Knowledge : Its acquisition, representation, and use.
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  • Quickly and confidently evaluate and diagnose skin biopsies with this book. Written from the perspective of both the histopathologist and clinician, this popular medical reference allows you to search by disease or pathologic feature to quickly locate key criteria and a differential diagnosis.
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  • One-stop resource for the differential diagnosis of common and rare radiologic findings and conditions in all regions of the body. For each finding and diagnosis, the book provides a complete list of differential diagnoses, as well as the features that will help the clinician differentiate diseases with similar findings. Concise descriptions aid the identification of key radiologic signs. Easy-to-use tables and bullet-point lists facilitate rapid review of important information about findings, differentiating features, and disease entities.
  • Historical review / Beverly Hashimoto -- Physics of digital mammography -- Digital mammographic equipment / Lloyd Kruetzer -- Normal anatomy -- Digital mammographic appearance of benign and malignant calcifications -- Digital mammographic characteristics of masses -- Digital mammographic technique for mammographic asymmetries / Beverly Hashimoto -- Digital mammographic characteristics of architectural distortion.
  • Evidence-based physiotherapy : what, why and how? -- What do I need to know? -- What constitutes evidence? -- Finding the evidence -- Can I trust this evidence? -- What does this evidence mean for my practice? -- Clinical guidelines as a resource for evidence-based physiotherapy -- When and how should new therapies be introduced into clinical practice? -- Making it happen -- Am I on the right track?
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    The endoscopy unit and staff -- Endoscopic equipment -- Patient care, risks, and safety -- Upper endoscopy : diagnostic techniques -- Therapeutic upper endoscopy -- Colonoscopy and flexible sigmoidoscopy -- Therapeutic colonoscopy -- Resources and links.
  • Indications for pacing -- Pacemaker technology -- Principles of pacemaker-myocardial interaction -- Programmability and specialized circuits -- Types of pacemakers and hemodynamics of pacing -- Dual-chamber pacing : special considerations -- Cardiac resynchronization therapy -- Rate-modulated pacing -- Implantable cardioverter defibrillator and antitachycardia pacing -- Pacemaker implantation -- Follow-up of the patient who has received a pacemaker.
  • Written by the founders of the SPARK program at Stanford University, this book is a practical guide designed for professors, students and clinicians at academic research institutions who are interested in learning more about the drug development process and how to help their discoveries become the novel drugs of the future. Often many potentially transformative basic science discoveries are not pursued because they are deemed "too early" to attract industry interest. There are simple, relatively cost-effective things that academic researchers can do to advance their findings to the point that they can be tested in the clinic or attract more industry interest.
  • Understanding and Maintaining the Cryostat / Philip Hyam -- Gross Examination of Tissues in the Frozen Section Room / Stephen R. Peters -- Embedding of Tissue for Frozen Section / Stephen R. Peters -- Cutting the Frozen Section / Stephen R. Peters -- Variables Affecting the Cutting Properties of Tissues and the Resulting Artifacts / Stephen R. Peters -- Fixation, Staining and Coverslipping of Frozen Section Slides / Stephen R. Peters and Catherine Susan Delia -- Microscopic Interpretation in the Frozen Section Setting / Stephen R. Peters -- Frozen Section Techniques Used in Mohs Micrographic Surgery / Barbara Beck and Stephen R. Peters -- Frozen Section Technique in the Animal Research Setting / Charles W. Scouten.
  • A Practical Guide to Human Cancer Genetics, 4th edition, is a comprehensive and up-to-date guide to the diagnosis, clinical features and management of inherited disorders conferring cancer susceptibility. This fully updated new edition covers risk analysis and genetic counseling for individuals with a family history of cancer, and includes a discussion of predictive testing and the organisation of the cancer genetics service. There is also information about the genes causing Mendelian cancer predisposing conditions and their mechanisms of action. This book is an invaluable reference source for students, general practitioners, geneticists and specialist clinicians in all disciplines.
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    Illustrations -- Acknowledgments -- pt. 1. Getting started -- 1. Introduction -- 2. A brief look at assessment -- Where does information literacy fit in? -- Where do libraries fit in? -- Levels of assessment -- Classroom assessment -- Programmatic assessment -- Institutional assessment -- Learning objectives -- Works cited and further reading -- 3. How to choose the right assessment tool -- Chapter organization -- pt. 2. The tools -- 4. Informal assessment techniques -- An overview of informal assessment -- Informal observations -- Informal questions -- Self-reflection -- Keys to success with informal assessment -- Tips for informal observations -- Tips for informal questioning -- Tips for instructor self-reflection -- Using the data from informal assessment -- Is informal assessment right for you? -- Works cited and further reading -- 5. Classroom assessment techniques -- An overview of classroom assessment techniques -- Preparation -- Examples of classroom assessment techniques -- Minute paper/muddiest point -- One sentence summary -- Defining features matrix -- Directed paraphrasing -- Pre-assessment using CATs -- Classroom response systems -- Using the results -- Are classroom assessment techniques right for you? -- Works cited and further reading -- 6. Surveys -- An overview of surveys -- Practical considerations -- Who and when -- Survey delivery -- Survey questions -- Steps for conducting a survey -- Are surveys right for you? -- Works cited and further reading -- 7. Interviewing -- An overview of interviewing -- Types of interviewing -- Informal interviewing -- Guided interviewing -- Open-ended interviewing -- Preparing for a successful interview -- Right after the interview -- Transcribing the data -- Analyzing the data -- Is interviewing right for your? -- Works cited and further reading -- 8. Focus groups -- An overview of focus groups -- Preparing for a successful focus group -- Conducting the focus group -- The focus group session -- Right after the session -- Transcribing the data -- Analyzing the data -- Example of a focus group study -- Assessment scenario -- The focus group plan -- Are focus groups right for you? -- Works cited and further reading -- 9. Knowledge tests -- An overview of knowledge tests -- Types of knowledge test items -- Creating knowledge tests -- Objective items -- Essay items -- Standardized tests -- Analyzing the data -- Are knowledge tests right for you? -- Works cited and further reading -- 10. Concept maps -- An overview of concept maps -- Types of concept maps -- Hierarchical concept maps -- Flat concept maps -- Creating and using concept maps -- Evaluating concept maps -- Is concept mapping right for you? -- Works cited and further reading -- 11. Performance and product assessments -- An overview of performance assessments -- Process -- Products -- Assignment design -- Writing an assignment prompt -- One last check of your assignment -- Scoring guides -- Analyzing data from performance assessments -- Are performance assessments right for you? -- Works cited and further reading -- 12. Portfolios -- An overview of portfolios -- What goes into a portfolio? -- Creating the portfolio assignment -- Programmatic and institutional assessment -- Collecting the material -- Electronic portfolios -- Assessing portfolios -- Are portfolios right for you? -- Works cited and further reading -- pt. 3. What to do with the information -- 13. Analyzing the data -- An overview of content analysis -- Steps in content analysis -- Software to assist with analyzing textual data -- An overview of descriptive statistics -- Steps in descriptive statistics -- Data tools -- Spreadsheets -- Statistical software -- Conclusion -- Works cited and further reading -- 14. Working with the results -- Sharing assessment results -- Identifying stakeholders -- Deciding what to share -- Presenting your results -- Putting assessment results to work -- Working with positive assessment results -- Working with negative results -- Conclusion -- Works cited and further reading -- Index.
  • Introduction to near-infrared spectra -- Alkanes and cycloalkanes -- Alkenes and alkynes -- Aromatic compounds -- Hydroxyl containing compounds -- Water -- Carbonyls -- Amines and amides -- P-H and S-H -- Carbohydrates -- Amino acids, peptides, and proteins -- Synthetic polymers and rubbers -- History of near-infrared (NIR) applications.
  • This is the second edition of a superbly illustrated manual on neck dissection that will serve as a roadmap for advanced surgeons and beginners alike. The reader is guided through the various cervical structures in a series of chapters depicting the methods employed by surgeons operating in vivo. The illustrations provide an overview of all surgical anatomy relevant to the treatment of oncologic patients. Compared with the first edition, revisions have been made when appropriate and an important new chapter has been added on microscopic anatomy and laryngeal cancer.
  • This simple guide to neurogenetics demystifies the overwhelming amount of information on the subject so you can identify key clinical features and understand your management options. Reach relevant differential diagnoses and provide appropriate counseling to your patients using the symptom-based approach. By integrating genetic and neurological approaches to diagnoses, this book ensures that the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis are clear and explicit. Concise and portable, this book is ideal for easy reference in clinical use. Details the underlying basic science and clinical features of genetic disorders by taking a symptom-based approach to provide you with a comprehensive understanding of the field. Focuses on the clinical application of neurogenetics to be of practical use to you in the clinic. Clarifies the neurological consequences of a genetic diagnosis and the genetic consequences of a neurological diagnosis by integrating genetic and neurological approaches to diagnoses. Discusses and evaluates necessary investigations so you know when to use them and when to refer. Highlights diagnostic and therapeutic tips so you can learn new concepts or refine your skills in practice. Refers to online sources, such as Online Mendelian Inheritance in Man (OMIM) and others, to help you supplement your knowledge.
  • Modern vascular neurology, particularly in the emergency setting, often requires a great capacity for analysis and synthesis. Physicians who manage these patients must have acquired multidisciplinary skills, including a good knowledge of clinical neurology and medical imaging, but they may also need to be skilled in cardiology and intensive care. The initial clinical and imaging examinations play a decisive role in the management strategy. This book, written by neurologists and neuroradiologists, is designed to help all physicians involved in the management of neurovascular disease. The format and contents of this book, including the latest guidelines from learned societies, are designed to provide a succinct and practical guide. Although this book is particularly devoted to ischaemic stroke, other neurovascular diseases, especially haemorrhagic stroke, are also discussed. This book should constitute a valuable tool for everyday practice for all medical personnel involved in neurovascular disease.
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    "This book describes and discusses the most commonly used office gynecologic procedures. The goal is to facilitate optimal management of our patients and their gynecologic problems. Written by the faculty, fellows and residents of the Stanford Department of Obstetrics and Gynecology who took great care to include the details for the performance of excellent office-based diagnosis and treatment, this book is an important tool for practitioners of our specialty. I extend my gratitude to Dr. Paul Blumenthal and my colleagues for this valuable effort and their commitment to outstanding patient care"--Provided by publisher.
  • Section 1. The palliative care approach -- Section 2. Cultural diversity in end-of-life care -- Section 3. Approach to the patient -- Section 4. Predicting life expectancy -- Section 5. Delivery of palliative care -- Section 6. Terminal care -- Section 7. Nonpain symptom management -- Section 8. Pain control -- Section 9. Palliative interventions -- Section 10. The palliative pediatric patient -- Section 11. Charting -- Section 12. Ethics at the end of life.
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    "This practical guide is written for the emergency department physician who cares for adults and children concurrently and provides all the information needed to diagnose and treat a wide variety of common and uncommon pediatric disorders. Each chapter takes a clinical perspective, emphasizing differences in adult and pediatric disease process and management. Key facts, special considerations, and pearls and pitfalls are highlighted, providing rapid access to vital knowledge in emergency situations. Sections are dedicated to specific pediatric populations, including neonates, adolescents, and children with special health care needs. High-quality photographs, illustrations and diagrams enhance the text throughout and tutorials cover pediatric imaging, pediatric EKG interpretation, procedural sedation, and procedures. Written by pediatric and emergency medicine specialists and subspecialty experts, this is a must-have text for emergency medicine physicians and trainees, as well as family practice health care practitioners"--Provided by publisher.
  • Charting / George T. Danakas -- Gynecologic anatomy / David L. Marchetti -- Abdominal surgical approaches / J. Kevin Fitzpatrick -- Diagnostic studies -- Contraception / Maria A. Corigliano -- Infertility evaluation -- Amenorrhea / Ivan D'Souza -- Abnormal uterine bleeding / George T. Danakas and Diane J. Sutter -- Endometriosis / Ronald E. Batt and Germaine M. Buck -- Gynecologic infections / D. Michael Slate II and Lawrence J. Gugino -- HIV infection in women / Michael Slate II and Lawrence J. Gugino -- Evaluation of lower abdominal and pelvic pain / Avi Sklar and Farkad Balaya -- Differential diagnosis of benign gynecologic conditions / Dennis M. Weppner -- Gynecologic oncology / Alexander B. Olawaiye -- Hirsutism / Arundathi G. Prasad -- Premenstrual syndrome / George T. Danakas and Ibrahim Joulak -- Menopause / Diane J. Sutter -- Labor, delivery, and obstetrics pain management / Farkad Balaya -- High-risk obstetrics -- Antenatal assessment -- Postpartum hemorrhage / John M. O'Brien -- Physiology in pregnancy / Arundathi G. Prasad.
  • Approach to the pediatric patient : gathering data and communicating information / Natalia Golova and Anthony J. Alario -- Routine health maintenance and preventive medicine : a guide to well-child care / Natalia Golova and Anthony J. Alario -- Differential diagnoses / Anthony J. Alario and Jonathan D. Birnkrant -- Dysmorphology and common syndromes / Dianne N. Abuelo -- The newborn infant / William J. Cashore. Adolescent medicine / Patricia Flanagan, Suzanne Riggs, and Zeev Harel -- Endocrinologic disorders / Cynthia H. Meyers-Seifer, Rebecca R. McEachern, and Philip A. Gruppuso -- Renal disorders / Natalia Golova, Anthony J. Alario, and M. Khurram Faizan -- Fluids and electrolytes : normal requirements and treatment of dehydration and electrolyte disturbances / Anthony J. Alario -- Acid-base disturbances / Fred F. Ferri and Anthony J. Alario -- Orthopedic conditions / Craig P. Eberson ... [et al.]. Rheumatic disorders / Ali Yalcindag, Bradley J. Bloom, and Anthony J. Alario -- Pediatric dermatology / Monika Upadhye Curlin, Priya Swamy Zeikus, and Jennie J. Muglia -- Hematologic/oncologic disorders / Christopher Paul Keuker and Edwin N. Forman -- Cardiovascular disorders / Shelley D. Miyamoto and Lloyd R. Feit -- Pulmonary and allergic diseases / Robert B. Klein, Anthony J. Alario, and Michael S. Schechter -- Gastrointestinal disorders / Albert M. Ross IV ... [et al.] -- Urologic conditions / Jeffrey M. Becker and Anthony A. Caldamone -- Infectious diseases / Anthony J. Alario ... [et al.]. Neurologic disorders / Sonia Partap and Randal C. Richardson -- Developmental disabilities / Maya Liza C. Lopez and Jo-Ann Blaymore Bier -- Behavioral and psychiatric disorders of childhood / Andrea R. Carlsen ... [et al.] -- Surgical conditions in infants and children / Hannah M. Huddleston, Thomas F. Tracy Jr., and Steven T. Cobery -- Toxicologic emergencies / Robert O. Wright, Gregory R. Lockhart, and William J. Lewander -- General approach to trauma / Aris C. Garro and Thomas H. Chun -- Child maltreatment / Shelly D. Martin and Christine Barron.
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    Role of psychiatric factors in medical practice / Roger Lowell McRoberts III -- Psychiatric interview and database / Richard J. Goldberg -- Medical evaluation of psychiatric symptoms / Richard J. Goldberg -- Delirium, dementia, and other cognitive disorders / Sandra A. Jacobson -- Alzheimer's disease: diagnosis and treatment / Richard J. Goldberg -- Depression: identification and diagnosis / Michael A. Posternak and Mark Zimmerman -- Antidepressants / Michael A. Posternak and Mark Zimmerman -- Bipolar disorder and mood-stabilizing drugs / Christine J. Truman -- Anxiety disorders: diagnosis and management / Richard J. Goldberg and Donn Posner -- Treatment of anxiety: medications and therapies / Richard J. Goldberg, Donn Posner, and Mark Zimmerman -- Sleep problems and the use of hypnotics / Richard P. Millman -- Psychotic symptoms, schizophrenia, and antipsychotic agents / Moataz M. Ragheb -- Somatoform disorders / Colin J. Harrington -- Behavioral emergencies forensic issues / Ali Kazim -- Alcohol and substance abuse / Michael D. Stein -- Electroconvulsive therapy / David A. Solomon -- Personality disorders / Daniela A. Boerescu -- Eating disorders, obesity, and nicotine dependence / Mark B. Elliot -- Sexual disorders / John P. Wincze -- The P450 system: drug interactions / Richard J. Goldberg -- Child and adolescent psychiatry / Joseph V. Penn -- Formulary.
  • Stat! -- Quick reference -- Skeletons and templates -- Medical illustrations -- Bugs and drugs -- Procedures -- Systems -- Trauma -- Rounds and services survival guide -- Medical Spanish.
  • This book, written by international experts, is a detailed guide to the Eustachian tube, with emphasis on those aspects of most relevance to the practitioner. The opening chapters document the clinical anatomy and provide essential information on physiology, with explanation of the new model of tubal mechanics and the use of Eustachian tube function tests. Diagnosis and therapy for the patulous Eustachian tube are then discussed, placing special emphasis on a novel conservative treatment regimen that has proven to be a breakthrough for patients with this clinical syndrome. A further extensive chapter examines overall function of the Eustachian tube, primarily from the middle ear surgeons viewpoint. Tuboplasty procedures, including laser tuboplasty, and tympanoplasty are described, and the implications of different middle ear pathologies for surgical treatment are explained. Conservative treatment of Eustachian tube obstruction and hearing aids for the nonaerated middle ear are also discussed. The previously unpublished treatment methods that are described in this book will be invaluable in ensuring the best possible clinical outcomes.
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    The language of the pedigree -- Practical inheritance -- Getting to the roots : recording the family tree -- Directed medical-genetic family history questions : separating the trees from the forest -- Using a pedigree to recognize individuals with an increased susceptibility to cancer -- Medical verification of family history, and resources for patients to record their genetic family histories -- The challenge of family history and adoption -- Family history and assisted reproductive technologies -- Genetic counseling : where to turn, what to expect, and the pedigree as a psychosocial assessment and counseling tool -- Pedigree predicaments.
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    The gynecologic examination / Pamela Charney -- Sexuality / Sharon J. Parish and William H. Salazar -- Menstrual disorders and abnormal bleeding / Shawn Kurtcheff and Mark Gibson -- Premenstrual syndrome / Janice Ryden -- Contraception / Alison B. Edelman -- Spontaneous and induced abortion / Laura D. Castleman and Paul D. Blumenthal -- Cervical cancer prevention / Auguste H. Fortin VI -- Vaginitis and sexually transmitted diseases / Roxanne Jamshidi and Jonathan Zenilman -- Gynecologic emergencies / Kindra Larson, Dee Fenner, and Janice Ryden -- Urinary incontinence / Lisa Granville and Dee Fenner -- Endometriosis / John C. Petrozza -- Chronic pelvic pain / Candace N. Howe and Andrea J. Rapkin -- Evaluation of pelvic masses / Anita L. Nelson, Robert M Sinow, and Monica Hau Hien Le -- Hysterectomy and alternatives / Mary T. Jacobson -- Menopause / Anne W. Moulton, Mary H. Hohenhaus, and Michelle Stozek Anvar -- Menopausal hormone therapy : benefits, risks and regimens / Rebekah Wang-Cheng and Ann Butler Nattinger -- Diseases of the vulva / Paula Zook -- Breast cancer screening and management of common breast problems / Leah Wolfe -- Preconception care / Joyce A. Sackey and Gerda Ellen Tapelband -- Infertility / Bert Scoccia and Janice Ryden -- Intimate partner violence / Joslyn W. Fisher, Amy Weil, and Christina Nicolaidis -- Lesbian health issues / Audrey S. Koh and Anne Rosenthal.
  • Since the development of 23G vitrectomy in 2004, the technique has revolutionized retinal surgery by overcoming a number of the problems associated with 20G and 25G systems and offering significant improvements in surgical capability and fluidics. This important book first discusses the instruments and equipment employed in 23G vitrectomy and then explains, step by step, the various surgical techniques with the aid of informative diagrams and many high-quality photos. In addition, videos are included that document the different procedures, from the straightforward to the demanding. This book will serve as an immensely useful guide for all surgeons who are intending to make use of this exciting and increasingly used technique.
  • Part I. Instrumentation / Instrumentation / Kazuya Akahoshi -- Part II. Ultrasound Catheter Probe / Ultrasound Catheter Probe (UCP) / Kazuya Akahoshi and Masaru Kubokawa -- Part III. Radial Endoscopic Ultrasonography (EUS) / Basic Scanning Methods of Radial EUS / Kazuya Akahoshi -- Radial EUS of the Esophagus and Mediastinum / Kazuya Akahoshi -- Radial EUS of the Stomach / Kazuya Akahoshi -- Radial EUS of the Anus and Rectum / Kazuya Akahoshi -- Radial EUS of Pancreatico-Biliary System / Kazuya Akahoshi -- Part IV. Linear EUS / Basic Scanning Techniques of Linear EUS / Amol Bapaye and Advay Aher -- Linear EUS of the Esophagus and Mediastinum / Amol Bapaye and Advay Aher -- Linear EUS of the Stomach / Amol Bapaye and Advay Aher -- Linear EUS of the Anorectum / Amol Bapaye and Advay Aher -- Linear EUS of the Pancreas, Biliary Tract and Liver / Amol Bapaye and Advay Aher -- Part V. Endoscopic Ultrasonography-Guided Fine Needle Aspiration (EUS-FNA) / Techniques of EUS-FNA / Amol Bapaye and Advay Aher -- Cytopathological Aspects of EUS-FNA / Vijayshri Pethe-Bhide and Amol Bapaye -- EUS-FNA of the Esophagus and Mediastinum / Amol Bapaye and Advay Aher -- EUS-FNA of Lesions of the Pancreas, Biliary Tract, and Liver / Amol Bapaye and Advay Aher -- EUS-FNA for Submucosal Tumor / Kazuya Akahoshi and Masafumi Oya -- Part VI. Interventional EUS / EUS Guided Drainage of Pancreatic Pseudocysts (PPC's), Abscesses and Fluid Collections (PFC's) / Amol Bapaye and Advay Aher -- EUS Guided Biliary and Pancreatic Duct Interventions / Amol Bapaye and Advay Aher -- EUS Guided Celiac Plexus Interventions / Rajkumar Wadhwa and Amol Bapaye -- EUS Guided Anorectal Interventions.
  • v. 1. Cranial approaches, vascular, traumas, cerebrospinal fluid, infections -- v. 2. Intracranial tumors, intraoperative explorations, pediatrics -- v. 3. Spine, functional, peripheral nerves, education.
  • I. Essential Foundations: -- 1. Thoracic Radiology -- 2. Respiratory Physiology -- 3. Resiratory Pathophysiology -- 4. Respiratory Effects of General Anesthesia -- 5. Physiology of One-Lung Ventilation -- 6. Idiopathic Acute Lung Injury following Thoracic Surgery -- II. Essential Technical Aspects -- 7. Thoracic Positioning & Incisions -- 8. Bronchoscopic Anatomy -- 9. echnical Aspects of Lung Isolation -- 10. Special Airway Devices for Thoracic Anesthesia: CPAP, PEEP, & Airway Exchange Catheters -- 11. Alternative Ventilatory Techniques -- 12. Respiratory Therapy Devices -- 13. Technical Aspects of Pain Control Procedures for Thoracic Surgery -- III. Essential Principals of Clinical Management -- 14. Preoperative Evaluation of the Thoracic Surgical Patient -- 15. Overview: Surgeon's Approach to the Patient with Lung Cancer -- 16. Principals of Anesthetic Management for Pulmonary Resection -- 17. Management of Common Complications Following Thoracic Surgery -- IV. Specific Thoracic Surgical Procedures: Surgical & Anesthetic Management Essentials -- 18. Flexible Bronchoscopy -- 19. Mediastinoscopy -- 20. Anterior Mediastinal Mass -- 21. Lung-Sparing Pulmonary Resections: Bronchoplastic/Sleeve Resection -- 22. Pneumonectomy -- 23. Extrapleural Pneumonectomy -- 24. Lung Volume Reduction Surgery -- 25. Plueral Space Procedures -- 26. Rigid Bronchoscopy -- 27. Laser Surgery of the Airway and Laser Safety -- 28. Tracheal Stent Placement -- 29. Anesthesia for Tracheostomy -- 30. Tracheal Resection and Reconstruction -- 31. Bronchopleural Fistula -- 32. Esophagectomy -- 33. Esophageal Perforation -- 34. Lung Transplantation -- 35. Miscellaneous Thoracic Surgical Procedures -- 36. Anesthesia for Pediatric Thoracic Surgery -- V. Essential of Pain Management following Thoracic Surgery -- 37. Acute Postoperative Pain Control following Thoracic Surgery -- 38. Chronic Post-Thoracotomy Pain Syndrome -- Index.
  • 2011 ClinicalKey
    Practical Hepatic Pathology-a new volume in the new Pattern Recognition series-offers you a practical guide to diagnosing every challenging liver biopsy that you encounter in your daily practice. Dr. Romil Saxena presents diagnoses according to a pattern-based organization that guides you from a histological pattern of injury, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish, full-color images capture key hepatic pathology patterns of injury, pathognomonic features and common variations of all major liver diseases and hepatic neoplasms, while a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in liver biopsies. Recognize the basic patterns of liver injury through an algorithmic approach and establish diagnosis by a pattern-based visual index present at the beginning of the book. Evaluate and interpret biopsy samples using superb, high-quality, full-color images that illustrate pathognomonic features and common variations. Get comprehensive information on major adult and childhood liver diseases, hepatic neoplasms and pre-neoplastic nodules including clinical features, laboratory tests, imaging findings and differential diagnosis. Understand the pathology and practice of liver transplantation with coverage of the clinical aspects of this procedure.
  • Introduction to informatics / Liron Pantanowitz -- Basic computing / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Networking / Muhammad A. Syed, Anil V. Parwani, and Liron Pantanowitz -- Databases / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Coding / Seung L. Park, Jacqueline Cuda, and Liron Pantanowitz -- Laboratory information systems / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Laboratory information system operations and regulations / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Reporting / Liron Pantanowitz -- Quality management / Liron Pantanowitz, Luke T. Wiehagen, and R. Marshall Austin -- Barcoding / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Informatics projects / Liron Pantanowitz -- Lean Six Sigman / Ioan C. Cucoranu, Anil V. Parwani, and Liron Pantanowitz -- Electronic medical records / Seung L. Park, Anil V. Parwani, and Liron Pantanowitz -- Digital imaging / Milon Amin, Anil V. Parwani, and Liron Pantanowitz -- Automated pap tests / Liron Pantanowitz -- Telecytology / Sara E. Monaco and Liron Pantanowitz -- Cytology online / Walid E. Khalbuss -- Bioinformatics / Somak Roy, Liron Pantanowitz, and Anil V. Parwani -- Research informatics / Somak Roy, Liron Pantanowitz, Anil V. Parwani.
  • Intensive Care for Elderly Patients: Clinical, Ethical and Economic Considerations / Marco Dei Poli and Marco Resta -- Is It Still Worth Treating At-Risk Patients with Perioperative Goal-Directed Haemodynamic Therapy? / Biagio Allaria -- Abdominal Compartment Syndrome and Fluid Replacement: A Dog That Bites Its Own Tail? / Massimo Girardis and Emanuela Biagioni -- Acute Liver Failure in Intensive Care / Andrea De Gasperi, Patrizia Andreoni, Stefania Colombo, Paola Cozzi and Ernestina Mazza -- Diuretics in Intensive Care: Positive and Negative Aspects / Pasquale Piccinni and Silvia Gramaticopolo -- Perioperative and Intensive Care Management of Haemorrhage: The Opinion of the Haemathologist / Marco Marietta -- Hypercapnic Acidosis in Protective Mechanical Ventilation (a Tolerated Compromise or Another Means of Protection?) / Biagio Allaria -- Are We Sure We Are Using Drugs Correctly in Critical Patients? / Biagio Allaria -- The Problem of Decontamination of the Digestive Tract and Gastric Acid Suppression in Intensive Care / Biagio Allaria -- Renal, Cardiac and Pulmonary Involvement in Patients with Supraventricular Tachycardia: A Typical Holistic Vision by an Intensive Care Physician / Biagio Allaria -- VAP (Ventilator-Associated Pneumonia) / Davide Chiumello and Tommaso Fossali -- Mechanical Ventilation in Patients with Acute Severe Asthma / Davide Chiumello and Sara Sher.
  • 1 Perioperative fluid therapy and fluid therapy in patients with sepsis. In search of clarification -- 2 Enough has been written about the treatment of ALI, but has enough been said about how to prevent it? -- 3 Prevention of perioperative myocardial ischemia -- 4 Respiratory complications after major abdominal surgery: causes, diagnosis, and prevention -- 5 Positive and negative aspects of aerosol therapies in ventilated patients -- 6 Update on lung imaging to select ventilation management in ARDS patients -- 7 Chest X-ray in ICU: an examination in which there is too much confidence. Possible alternatives -- 8 Continuous renal replacement therapy (CRRT) in intensive care -- 9 Loss of autoregulation of interstitial fluid dynamic in patients with sepsis and mechanisms causing edema -- 10 How to prevent and effectively treat postoperative shivering -- 11 Epidemiology, etiopathogenesis, diagnosis and treatment of postoperative paralytic ileus in intensive care -- 12 Which adult patients undergoing non-cardiac surgery should be monitored postoperatively in ICU? -- 13 Invasive candidiasis in the intensive care setting.
  • This book describes the state of the art concerning some of the most hotly debated topics in anesthesia and intensive care and is at the same time intended to serve as a useful practical guide that will assist in improving outcomes. The topics covered are wide ranging and include, for example, use of the prone position in ARDS, the role of therapeutic hypothermia in the critically ill, the value of immunoglobulins in the treatment of severe sepsis, drug management of septic shock, new strategies for prevention of ventilator-associated pneumonia, non-invasive ventilation outside of the ICU, management of postoperative bleeding, and prognostic factors in cardiac arrest. Written by recognized experts in the field, the book will offer a comprehensive and easy to understand update for specialists and students of anesthesia and intensive care.
  • "Preface This book is part of a journey--a personal journey of development and discovery, where through excellent teachers and challenging life and work lessons, I have, over time, developed a real passion for leadership. But not any leadership, leadership which is authentic and sincere, focused on a way forward; leadership which is ethical and compassionate, which comes from a place of integrity, and which has within it a genuine desire for growth and positive change for all those involved, be that for ourselves, the colleagues we work with or the patients we serve. It is a leadership that is prepared to put personal ego aside to ensure the greater good of others and the service we work within. It is a leadership that wants to make a real difference and will do what it takes to ensure that the goal is reached within an ethical and compassionate framework. To bring others along on that journey, this book introduces people with whom I have connected over the last few years, who have inspired me and shown me what this real, authentic and compassionate leadership is all about. The authors here have all shown real leadership in their own walks of professional life, are all passionate about what they do for others and are generous enough to share their learning to assist others in their ongoing leadership development. The focus of the book is twofold: firstly, to assist personal leadership development, for personal satisfaction and growth, and secondly, to improve healthcare delivery to patients, through excellence in personal practice. I believe that it is through the passion, ability and drive of individuals (you and me) that we will change and challenge practices to ensure that patients get the best possible care in all healthcare contexts"--Provided by publisher.
  • "This volume is intended for the diverse range of pain clinicians looking for applications in their daily practice, pain researchers seeking extensive background on relevant topics, fellows reviewing for the pain medicine boards, and residents who want a complete discussion of the breadth of the field. Each chapter provides practical applications of the various and diverse acute and chronic pain syndromes"--Pref.
  • 2011 ClinicalKey
    Practical Management of Pediatric and Adult Brachial Plexus Palsies covers in-depth surgical techniques for managing disorders of this crucial nerve complex so that you can most effectively treat injuries in patients of any age. Drs. Kevin Chung, Lynda Yan, and John McGillicuddy present a multidisciplinary approach to pediatric brachial plexus injury treatment and rehabilitation, obstetric considerations, and other hot topics in the field. With access to the full text and surgical videos online at, you'll have the dynamic, visual guidance you need to manage injuries to the brachial plexus. Access the fully searchable text online at, along with surgical videos demonstrating how to perform key procedures. See cases as they present in practice through color illustrations, photos, and diagrams that highlight key anatomical structures and relationships. Apply multidisciplinary best practices with advice from internationally respected authorities in neurosurgery, orthopaedics, plastic surgery, and other relevant fields. Hone your technique with coverage that emphasizes optimizing outcomes with pearls and discussions of common pitfalls. Prepare for collaborating with other physicians thanks to a multidisciplinary approach that covers medical and legal aspects in addition to surgery. Find information quickly and easily with a full-color layout.
  • An overview of the management of thyroid cancer -- The UK evidence-based guidelines for the management of thyroid cancer: key recommendations -- Thyroid cancer multidisciplinary team and the organisational paradigm -- Thyroid cancer form the perspective of a patient -- The role of the specialist nurse -- The role of the clinical psychologist -- Thyroid nodules -- Thyroid cancer and the general practitioner -- The role of pathologist -- Thyroid cancer and the endocrinologist -- The specialist endocrine surgeon -- Initial thyroid surery for patient with differentiated thyroid carcinoma -- Management of cervical lymph nodes in differentiated thyroid cancer -- Complications of thyroid surgery -- Non-surgical management of thyroid cancer -- Fertility following treatment with iodine-131 for thyroid cancer -- Recombinant human TSH (rhTSH): use in papillary and follicular thyroid cancer -- Thyroglobulin -- Follow-up of patients with differentiated thyroid carcinoma --- Management of differentiated thyroid carcinoma patients with negative whole-body radioiodine scans and elevated serum thyroglobulin levels -- Medullary thyroid cancer: diagnosis and management -- Nonmedullary thyroid cancer and the role of the geneticist -- Thyroid cancer in childhood -- Radiation-induced thyroid cancer: lessons from Chernobyl -- The use of stable potassium iodide (KI) in the event of a nuclear emergency -- Ultrasound of the thyroid -- Diagnostic nuclear medicine investigations in the management of thyroid cancer -- CT and MRI in thyroid cancer -- Papillary microcarcinoma of the thyroid -- Rare thyroid cancers -- Management of anaplastic thyroid cancer -- Specialist palliative care for anaplastic thyroid carcinoma -- Emerging therapies for thyroid cancer -- Clinical trials for thyroid carcinoma: past, present, and future.
  • This proposed book would cover all aspects of basic echocardiography: the nuts and bolts of ultrasound imaging, all of the views involved in an echocardiogram, step by step guides on how to perform all basic calculations and the normal/abnormal ranges for such calculations, descriptions of views/calculations to perform in any cardiac emergency situations. More importantly, it will include specific diagnostic algorithms fitted to address the differential diagnosis in a variety clinical scenarios. This book is aimed at everybody who is learning to perform and interpret echocardiograms.
  • Part 1. Setting Up and Running an IVF Laboratory / Building the Laboratory / Dean E. Morbeck and Marlena Duke -- Air Quality Management / Johan Guns, Ronny Janssens and Martine Vercammen -- Organizational Aspects of the Laboratory in a Tertiary Care ART Center / Nancy L. Bossert and Christopher De Jonge -- Quality Control Management / William R. Boone and H. Lee Higdon -- Daily, Weekly, and Regular Preparations for the IVF Laboratory / Michael A. Britt and Klaus E. Wiemer -- Risk and Safety in the IVF Clinic / Peter Sjoblom and Julius Hreinsson -- Journey of Human Gametes In Vitro: 1978-2010 / Zeev Shoham. Part 2. IVF Laboratory Equipment and Culture Systems -- Essential Instruments and Disposable Supplies for an IVF Laboratory / Leslie Weikert, Christa Fralick and Klaus E. Wiemer -- Co2 and Low-O2 Incubators / Marius Meintjes -- IVF Workstations / Nicolas Prados and Alex C. Varghese -- Culture Media in IVF: Decisions for the Laboratory / Jason E. Swain and Thomas B. Pool. Part 3. In Vitro Fertilization -- Oocyte Denuding / Roberta Maggiulli, Filippo Ubaldi and Laura Rienzi -- Assessment of Oocyte Quality / Basak Balaban, Turgay Barut and Bulent Urman -- Polarization Microscopy / Markus Montag, Maria Köster and Hans van der Ven -- Cumulus Cell Gene Expression in Assessment of Oocyte Quality / Dagan Wells. Part 4. Embryo Culture Methods -- Short Culture: Day 1/Day 2/Day 3 Embryo Culture / Patrick Quinn -- Extended Culture in IVF / David K. Gardner and Michelle Lane -- In Vitro Maturation of Human Oocytes / Baris Ata, Jack Huang and Ri-Cheng Chian -- In Vivo Embryo Culture Device / Claude Ranoux -- Microfluidics for Gamete Manipulation and Embryo Culture / Gary D. Smith, Charles Bormann and Shuichi Takayama. Part 5. Sperm Processing and Selection -- Sperm Assessment: Traditional Approaches and Their Indicative Value / Margot Flint, Fanuel Lampiao, Ashok Agarwal and Stefan S. du Plessis -- Sperm Assessment: Novel Approaches and Their Indicative Value / De Yi Liu, Harold Bourne, Claire Garrett, Gary N. Clarke and Shlomi Barak, et al. -- Sperm Processing for IVF / Ralf Henkel -- PESA/TESA/TESE Sperm Processing / Sandro C. Esteves and Sidney Verza -- Processing Sperm Samples in HIV-Positive Patients / Thamara Viloria, Marcos Meseguer, Antonio Pellicer, José Remohí and Nicolás Garrido -- Intracytoplasmic Morphologically Selected Sperm Injection / P. Vanderzwalmen, Magnus Bach, Batsuren Baramsai, A. Neyer and Delf Schwerda, et al. -- Sperm Testing and ICSI Selection by Hyaluronic Acid Binding: The Hyaluronic Acid-Coated Glass Slide and Petri Dish in the Andrology and IVF Laboratories / Gabor Huszar -- Electrophoretic Sperm Separation / Steven Fleming and John Aitken -- Magnetic-Activated Cell Sorting of Human Spermatozoa / Enver Kerem Dirican -- Polscope-Based Sperm Selection / Luca Gianaroli, Cristina Magli, Andor Crippa, Giorgio Cavallini and Eleonora Borghi, et al.. Part 6. Insemination Procedures -- Intrauterine Insemination / Gautam N. Allahbadia and Rubina Merchant -- Conventional IVF Insemination / Liesl Nel-Themaat, Thomas Elliott, Ching-Chien Chang, Graham Wright and Zsolt Peter Nagy -- Intracytoplasmic Sperm Injection / Gianpiero D. Palermo, Queenie V. Neri, Devin Monahan, Takumi Takeuchi and Peter N. Schlegel, et al. -- Mechanism of Human Oocyte Activation During ICSI and Methodology for Overcoming Low or Failed Fertilization / Dmitri Dozortsev and Mohammad Hossein Nasr-Esfahani. Part 7. Micromanipulators and Micromanipulation -- Hydraulic Manipulators for ICSI / Hubert Joris -- Research Instruments Micromanipulators / Steven Fleming and Catherine Pretty -- Eppendorf Micromanipulator: Setup and Operation of Electronic Micromanipulators / Ehab Abu-Marar and Safa Al-Hasani -- The Leica Microsystems' IMSI System / Christiane Wittemer, Bruno Laborde, Frederic Ribay and Stephane Viville -- Automated Robotic Intracytoplasmic Sperm Injection / Zhe Lu, Xinyu Liu, Xuping Zhang, Clement Leung and Navid Esfandiari, et al. -- Oocyte Treatment and Preparation for Microinjection / Thomas Ebner -- Livestock Production via Micromanipulation / Akira Onishi and Anthony C. F. Perry. Part 8. Embryo Evaluation, Grading, and Assisted Hatching -- Pronuclear Scoring in Human In Vitro Fertilization / Lynette Scott -- Cumulative Morphological Assessment of Embryo Quality / Barry Behr and Aparna Hegde -- Metabolomics: The ViaMetrics-E Procedure for Assessing Embryo Viability / D. Sakkas, L. Botros, M. Henson, K. Judge and P. Roos -- Oxygen Consumption as an Indicator of Oocyte and Embryo Viability / Ana S. Lopes -- Gene Expression Changes During Human Early Embryo Development: New Applications for Embryo Selection / Samir Hamamah, Said Assou, Imène Boumela and Hervé Dechaud -- Amino Acid Turnover as a Biomarker of Embryo Viability / Christine Leary, Danielle G. Smith, Henry J. Leese and Roger G. Sturmey -- Real-Time Embryo Monitoring Device for Embryo Selection / Gábor Vajta and Thorir Hardarson -- Assisted Hatching in IVF / Itziar Belil and Anna Veiga. Part 9. Biopsy Procedures on Oocytes and Embryos -- Polar Body Biopsy / Markus Montag, Maria Köster, K. van der Ven and Hans van der Ven -- Cleavage-Stage Embryo Biopsy / Alan R. Thornhill -- Embryo Biopsy for PGD: Current Perspective / Steven J. McArthur, Don Leigh, Maria Traversa, James Marshall and Robert P. S. Jansen -- Microarrays and CGH for PGD of Chromosome Abnormalities and Gene Defects / Gary Harton and Santiago Munné. Part 10. Cryopreservation -- Sperm Cryopreservation / Fabio Firmbach Pasqualotto, Eleonora Bedin Pasqualotto, Edson Borges and Ashok Agarwal -- Slow Freezing of Oocytes / Giovanni Coticchio and Lucia De Santis -- Vitrification: Research in Animal Models / Gábor Vajta -- Oocyte Vitrification / Ana Cobo -- Slow Freezing of Embryos / Liesl Nel-Themaat, Ching-Chien Chang, Thomas Elliott, Patricia Bernal and Graham Wright, et al. -- Vitrification of Embryos / Juergen Liebermann, Joe Conaghan, Zsolt Peter Nagy and Michael Tucker -- Directional Freezing of Reproductive Cells, Tissues, and Organs / Amir Arav -- Ovarian Tissue Cryopreservation / Jennifer L. Kulp, J. Ryan Martin and Pasquale Patrizio. Part 11. Embryo Transfer -- Assessment of Uterine Receptivity / Hakan Cakmak and Hugh S. Taylor -- Single Embryo Transfer / Thorir Hardarson and Matts Wikland -- Ultrasound-Guided Embryo Transfer (Abdominal/Vaginal): An Evidence-Based Evaluation / Ahmed M. Abou-Setta -- Cumulus-Aided Embryo Transfer / Firuza R. Parikh, Nandkishor J. Naik, Dattatray J. Naik and Dhanajaya Kulkarni. Part 12. Management and Regulation in the ART Laboratory -- Data Management in the ART Laboratory: Requirements and Solutions / Timothy Brown, Bruce R. Gilbert and Bruce R. Gilbert -- Regulation, Licensing, and Accreditation of the ART Laboratory / Doris Baker -- Legislation in the United Kingdom / Rachel Cutting -- Regulation, Licensing, and Accreditation of the ART Laboratory in Europe / Julius Hreinsson and Peter Sjoblom -- Regulation, Licensing, and Accreditation of ART Laboratories in India / B. N. Chakravarty and Rita Modi -- Troubleshooting in the Clinical Embryology Laboratory: The Art of Problem-Solving in ART / Kathryn J. Go, Jay C. Patel and Rick Dietz. Part 13. Special Topics -- The Role of Mitochondria in the Establishment of Developmental Competence in Early Human Development / Jonathan Van Blerkom -- Nuclear and Cytoplasmic Transfer: Human Applications and Concerns / Josef Fulka and Helena Fulka -- Cytoskeletal Architecture of Human Oocytes with Focus on Centrosomes and Their Significant Role in Fertilization / Heide Schatten, Vanesa Y. Rawe and Qing-Yuan Sun -- Molecular Mining of Follicular Fluid for Reliable Biomarkers of Human Oocyte and Embryo Developmental Competence / Jonathan Van Blerkom.
  • This practical handbook is based on an internal working manual developed by staff and fellows at Mount Sinai Heart Cardiovascular Catheterization Laboratory, renowned for its high-volume and low complication complex coronary procedures. The Practical Handbook of Interventional Cardiology captures the knowledge and methodological know-how from leaders in interventional cardiology, it intends to guide users in a stepwise, methodical and practical approach through various cardiac interventional procedures in order to achieve maximum patient safety and improved outcomes. From patient selection, preoperative work-up, setting up equipment to step-by-step illustrations of various procedural details and troubleshooting, this handbook captures all the details necessary to perform the simplest to the most complex cardiac interventions. The book is designed for cardiologists and trainees who desire an efficient way to review the steps of various cardiac interventional procedures and a quick, reliable reference for everyday use.
  • Chronic rhinosinusitis (CRS) is an inflammatory disorder of the nose and paranasal sinuses with symptoms persisting for at least 3 months. The treatment paradigm for CRS includes medical therapy as the cornerstone, coupled with endoscopic sinus surgery in refractory cases. To date, however, no FDA-approved treatments exist for medical treatment of CRS, and most treatment algorithms rely on expert opinion supplemented by available peer-review data. This underscores the need for a comprehensive primer to optimize the care of CRS patients. This book is a detailed compendium on the medical and surgical treatment of CRS, with or without polyposis. Detailed coverage is provided of a wide range of topics, including pathophysiologic mechanisms, medical and surgical management of CRS and its subsets, medical therapy in the pre- and postoperative period, specific medical therapeutic classes currently employed in CRS patients, and optimization of the efficacy of endoscopic sinus surgery for postoperative medical therapy. Each chapter highlights key aspects of specific therapies, including mechanism of action, indications, dosages, side-effects, and available clinical efficacy data, and emphasizes practical management pearls and pitfalls from experts in the field. Operative techniques for endoscopic sinonasal procedures for CRS are also outlined. This book will be a valuable resource for practicing general otolaryngologists, rhinologists, and allergists as well as residents and fellows in training. It will also serve as a reference guide for physician assistants, nurse practitioners, and nurses involved in the care of CRS patients.
  • "While the first edition of this book was written during my 9 years working at the University of Gt̲tingen in the field of MR mammography, this second edition reflects not only the innovative changes in the performance and analysis of MR mammography but also my new vantage point modified by the shift of my working field. The current edition includes all the experience I have accumulated during the last 7 years of work at the Women's Health Care Center, Gt̲tingen. In this frame of reference, where individualized and optimal diagnostic strategies are implemented for the early detection of breast cancer, MR mammography has increasingly earned a central role. It has also shown itself to be the most reliable diagnostic method for staging and follow-up after breast cancer"--Provided by publisher.
  • Shoulder: Anatomy and Techniques -- Shoulder 1: Supraspinatus Tendon -- Shoulder 2: The SASD Bursa, Rotator Interval and Other Rotator Cuff Tendons -- Shoulder 3: Beyond the Rotator Cuff -- Arm and Elbow Joint: Anatomy and Techniques -- Disorders of the Elbow: Lateral -- Disorders of the Elbow: Medial -- Disorders of the Elbow: Anterior -- Disorders of the Elbow: Posterior -- Forearm and Wrist Joint: Anatomy and Techniques -- Disorders of the Wrist: Radial -- Disorders of the Wrist: Ulnar Side -- Disorders of the Wrist: Miscellaneous -- Finger Anatomy and Techniques -- Disorders of the Fingers and Hand -- Hip Joint and Thigh: Anatomy and Techniques -- Disorders of the Groin and Hip: Groin Pain -- Disorders of the Groin and Hip: Anterior -- Disorders of the Groin and Hip: Lateral and Posterior -- Disorders of the Groin and Hip: Paediatric Hip -- Knee Joint and Calf: Anatomy and Techniques -- Knee Pat hology -- Ankle Joint and Forefoot: Anatomy and Techniques -- Disorders of the Ankle and Foot: Posterior -- Disorders of the Ankle and Foot: Anterior -- Disorders of the Ankle and Foot: Lateral -- Disorders of the Ankle and Foot: Medial -- Disorders of the Ankle and Foot: Forefoot -- Musculoskeletal Intervention: General Principles -- Specific Intervention Techniques -- Ultrasound of Soft Tissue Masses -- Ultrasound Imaging of Joint Disease -- Ultrasound of Muscle Injury.
  • Assessment of the Renal Patient -- Urine Analysis -- Imaging in Nephrology -- Kidney Biopsy -- Acute Kidney Injury: Epidemiology and Assessment -- Acute Kidney Injury: Management and Prevention -- Acute Renal Replacement Therapy -- Hepatorenal Syndrome -- Common Electrolyte Disorders -- Acid-Base Disorders -- Diagnosis and Investigation of the Hypertensive Patient -- Management of High Blood Pressure -- Podocytopathies -- Management of the Nephrotic Patient: The Overall Approach to the Patient with Nephrotic Syndrome (NS) -- Management of the Nephrotic Patient: Treatment of ECF Volume Expansion Due to Nephrotic Syndrome in Adults -- Minimal Change Disease and Focal Segmental Glomerulosclerosis -- Membranous Nephropathy -- Membranoproliferative Glomerulonephritis and C3 Glomerulopathy -- IgA Nephropathy and Henoch-Schonlein Purpura -- Systemic Small Vessel Vasculitis -- Goodpasture's or Anti-glomerular Basement Membrane (GBM) Disease -- Systemic Lupus Erythematosus, Antiphospholipid Syndrome and the Kidney -- Practical Immunosuppression Guidelines for Patients with Glomerulonephritis -- Infectious Diseases and the Kidney -- Blood-Borne Viruses and the Kidney -- Tubulointerstitial Nephritis -- Rheumatological Conditions and the Kidney -- Multiple Myeloma and the Kidney -- Amyloidosis -- Thrombotic Microangiopathies -- Sickle Cell Disease and Other Haematological Disorders Involving the Kidney -- Diabetes and the Kidney -- Pregnancy and the Kidney -- Disease of the Renal Vessels -- Urinary Tract Infection -- Renal Stone Disease -- Congenital Anomalies of the Kidneys and Urinary Tract -- Acquired Urinary Tract Obstruction -- Kidney Cancer -- Inherited Renal Tumour Syndromes -- Polycystic Kidney Disease -- Other Cystic Kidney Diseases -- Genetic Disorders of the Glomerular Basement Membrane -- Anderson-Fabry Disease and Other Inherited Lipid Disorders of the Kidney -- Inherited Metabolic Disease -- Dermatology in Kidney Disease -- Chronic Kidney Disease: Epidemiology and Causes -- Chronic Kidney Disease: Management -- Transition -- Anaemia Management in Chronic Kidney Disease -- Chronic Kidney Disease: Mineral and Bone Disorder (CKD-MBD) -- Chronic Kidney Disease: Cardiovascular Complications -- Coagulation in Kidney Disease -- Symptom Control and Palliative Care in Advanced CKD -- Nutrition and Kidney Disease -- Pharmacology and the Kidney -- Prevention of Infection in Kidney Patients -- Setting Up and Running a Haemodialysis Service -- Vascular Access: Improving Outcomes for Haemodialysis Patients -- Vascular Access: Fistulae and Grafts -- Complications of Maintenance Haemodialysis and How to Avoid Them -- Providing a Peritoneal Dialysis Service -- Peritoneal Dialysis Prescription -- Complications of Peritoneal Dialysis and How to Avoid Them -- Assessment of the Potential Transplant Donor -- Assessment of the Potential Transplant Recipient -- Tissue Typing, Crossmatch and Antibody Incompatibility in Kidney Transplantation -- Surgical Aspects of Kidney and Pancreas Transplantation -- Management of the Acute Transplant -- Immunosuppression for Kidney Transplantation -- Infectious Complications of Transplantation -- Long-Term Management of Kidney Transplant Recipients (KTRs) -- International Health Partnerships.
  • Machine generated contents note: SECTION I Techniques and Safety -- 1.History and Introduction -- 2.Performing a Cerebral Arteriogram -- 3.Spinal Angiography: Technical Aspects -- 4.Pediatric Neuroangiography: Technical Aspects -- 5.Safety and Complications -- 6.Radiation Risks and Safety -- SECTION II Anatomy -- 7.Embryology of the Cranial Circulation -- 8.Aortic Arch -- 9.The Circle of Willis -- 10.The Internal Carotid Artery -- 11.The Anterior Cerebral Artery -- 12.The Middle Cerebral Artery -- 13.The Posterior Cerebral Artery -- 14.The Extradural Vertebral Arteries -- 15.The Arteries of the Posterior Fossa -- 16.The Venous System -- 17.The External Carotid Artery and Extracranial Circulation -- SECTION III Vascular Diseases: Diagnosis and Treatment -- 18.Intracranial Aneurysms, Diagnosis and Treatment -- 19.Vascular Malformation of the Brain -- 20.Cranial Dural Vascular Malformations -- 21.Vascular Malformations of the Spine -- 22.Pediatric Ischemic Stroke and Arteriopathy -- Contents note continued: 23.Carotid-Cavernous Fistulas -- 24.Nonaneurysmal Perimesencephalic Subarachnoid Hemorrhage -- 25.ENT Bleeding and Tumor Embolization -- 26.Reversible Cerebral Vasoconstriction Syndrome -- 27.Vasculitides Involving the Central Nervous System -- 28.Bow Hunter's Stroke -- 29.Dural Sinus Occlusive Disease -- 30.Cerebral Vasospasm -- 31.Angioplasty and Stenting of Atherosclerotic Disease -- 32.Endovascular Treatment of Ischemic Stroke -- 33.Vein of Galen Malformations.
  • Hypoxic-ischemic brain damage / Alejandro A. Rabinstein and Steven Resnick -- Clinical-anatomical syndromes of ischemic infarction / Alejandro A. Rabinstein and Steven Resnick -- Acute stroke imaging / Alejandro A. Rabinstein and Steven Resnick -- Cardiac embolism / Alejandro A. Rabinstein and Steven Resnick -- Extracranial large artery atherothrombosis / Sebastian Koch -- Intracranial atherosclerotic disease / Jose G. Romano -- Small vessel disease / Alejandro A. Rabinstein and Steven Resnick -- Uncommon causes of stroke / Alejandro A. Rabinstein and Steven Resnick -- Spinal cord infarction / Alejandro A. Rabinstein and Steven Resnick -- Spontaneous intraparenchymal hemorrhage / Alejandro A. Rabinstein and Steven Resnick -- Secondary intraparenchymal hemorrhages / Alejandro A. Rabinstein and Steven Resnick -- Subarachnoid hemorrhage / Alejandro A. Rabinstein and Steven Resnick -- Vascular anomalies of the brain / Nils Mueller-Kronast -- Cerebral venous thrombosis / Alexander Y. Zubkov, Steven Resnick, and Alejandro A. Rabinstein.
  • Print Material
  • Print Material
  • Periarticular ligamentous tissue: a biochemical and physiologic assessment / David Amiel, Sakae Sano -- Meniscus / Julie A. dodds, Steven P. Arnoczky -- Articular cartilage: a brief review of its structure, function, and repair / Wayne H. Akeson, William Bugbee -- Skeletal muscle and tendon / Thomas M. Best, John J. Wilson -- Cervical spine injuries in the athlete / Rahul Banerjee, Michael P. Bradley, Mark A. Palumbo, Paul D. Fadale -- The thoracolumbar spine / Donald Chow -- Functional spinal rehabilitation / Lorraine Hendry -- Scapulothoracic dysfunction, burners, stingers, thoracic outlet syndrome, and miscellaneous nerve injuries / Marc R. Safran, Anthony C. Luke -- Head injures and concussion / Andrew d. Pearle, Ronnie Barnes, Russell F. Warren -- Shoulder anatomy and biomechanics / Dawn L. Swarm, Andrew T. Mahar, Derek W. Weichel, Robert A. Pedowitz -- Shoulder impingement / James Patrick Tasto, John K. Locke -- Shoulder labral tears and instability / George F. Hatch III, John G. costouros, Peter J. MIllett, Jon J.P. Warner -- The rotator cuff / Richard K.N. Ryu, Graham R. Hurvitz -- Cartilage / Coarlos A. Guanche -- Pectoralis major tendon ruptures / George K. Bal, Carl J. Bansamania -- Acute injuries: shoulder fractures and acromioclavicular and sternoclavicular joint injuries / Robert Talac, Joel J. Smith -- Adhesive capsulitis / Scott P. Fischer, Serge Kaska -- Arthroscopic rotator cuff repair / James C. Esch, Jeffrey W. Taborlane -- Thermal treatment, sutures, knots, and bone anchors / Robert A. Pedowitz -- Throwing injuries / Walter A. Thomas, Heinz R. Hoenecke, Jan Fronek -- Principles of shoulder rehabilitation / Benjamin D. Rubin -- Elbow injuries / Ronald M. Selby, Marc R. Safran, Stephen J. O'Brien -- Injuries of the wrist and hand / Ethan R. Wiesler, Jian Shen, Anastasios Papadonikolakis -- Anatomy and kinematics of the hip / Mark R. Hutchinson, John Hung, J.W. Thomas Byrd -- Hip arthroscopy / Michael H. Dienst -- Intra-articular lesions / Aaron A. Bare, Carlos A. Guanche -- Hip morphology and related pathology / J.W. Thomas Byrd -- Extra-articular lesions / Aaron A. Bare, Carlos A. Guanche -- Snapping hip syndrome / J.W. Thomas Byrd -- Occult groin injuries: athletic pubalgia, sports hernia, and osteitis pubis / Michael B. Gerhardt, John A. Brown, Eric Giza -- Sports related boney lesions of the hip: fractures, stress fractures, avulsion, AVN, dislocation, and subluxation / Carlos A.M. Higuera, Joshua M. Polster, Wael K. Barsoum, Viktor E. Krebs -- Basic science of the knee / Donald H. Hohnson, Paul Johnson, Ali Alsuwaidi -- The anterior cruciate ligament -- Anterior cruciate reconstruction / Andrew Pickle, Aaron Campbell, Donald H. Johnson -- Posterior mini-incision ACLR hamstring harvest / Chadwick Prodromos -- Anatomic double bundle anterior cruciate ligament reconstruction / Steven B. Cohen, James Starman, Freddie H. Fu -- Ligament injury and pain management / R. Lance Synder, Eric C. McCarty -- Medial collateral ligament / Donald H. Johnson -- Posterior cruciate ligament and posterolateral reconstruction / Gregory C. Fanelli - Posterior curciate ligament reconstruction with the posterior inlay graft / Donald H. Johnson -- The ACL PCL injured (dislocated) knee / Gregory C. Fanellis, Daniel R. Orcutt, Justin D. Harris, David Zijerdi, Craig J. Edson -- The meniscus / Monika Voleshy, Donald H. Johnson -- Meniscus allografts / Walter R. Shelton -- Patellar problems in athletes / Jeffrey Halbrecht -- Fractures - tibial plateau, distal femur, patella, avulsions of the intercondylar eminence, Osgood-Schlatter disease / James H. Lubowitz, Wylie S. Elson, Dan Guttmann -- Tendon disorders / William D. Stanish, Horacio Yepes, Amro Al-Hibshi -- Chondral injuries and osteoarthritis -- Chondral injuries in the knee / F. Alan Barber -- Osteochondritis dissecans on the knee / Dawn L. Swarm, Robert A. Pedowitz Cartilage transplantation / Alberto Gobbi, Ramces A. Francisco -- High tibial osteotomy / Tim Spalding, Price A.M. Gallie -- Unicompartmental knee replacement / Jack M. Bert -- Anterior cruciate ligament reconstruction with patellar tendon autograft: principles of rehabilitation / K. Donald Shelbrourne, Cairon Pfennig, Scott E. Lawrance -- Leg, ankle, and foot: history, physical, and investigations / Kevin J. Wing, Alastair Younger -- Muscle strains and contusions / Michael P. Swords, Douglas P. Dietzel -- Chronic compartment syndrome / Robert A. Pdeowitz, Derek W. Weichel -- Instability of the ankle / Murray J. Penner -- Treatment of osteochondral lesions of the talar dome / James W. Stone -- Tendon disorders in the lower extremity / Mark A. Glazebrook -- Stress fractures of the athletic leg, ankle, and foot / Donald R. Boahy, Jonathan P. Cornelius, John G. Anderson -- Ligamentous lisfranc joint injuries: leg - ankle - foot: midfoot injuries, lisfranc / Michael S. Aronow -- Hallux valgus in the athlete / Walter J. Pedowitz, David I. Pedowitz -- Stress fractures in athletes / Kurt P. Spindler, Michael S. George, Christopher C. Kaeding, Annunziato Amendola -- Female issues in sport: risk factors and prevention of ACL injuries / Ligament injuries in children and adolescents / Patrick S. Brannan, Henry G. Chambers -- Environmental issues for the athlete / Mark D. Bracker, Margoire Delo, Elise T. Gordon, Judy R. Schauer -- Team physician issues; preparticipation evaluation / Bernie Lalonde -- Running on the field / Richard Hawkins -- Traveling team physician / Chadwick Prodromos -- Mass participation events / Helen D. Iams, James Williams -- Team physician consensus statement -- Sideline preparedness for the team physician -- Team physician and conditioning of athletes for sports -- Team physician and return to play issues -- Female athlete issues for the team physician.
  • Normal bone anatomy / Michael J. Klein -- Patterns in radiology / D. Lee Bennett and Georges Y. El-Khoury -- Clinical patterns of orthopedic disease / Kevin B. Jones and Joseph A. Buckwalter -- Patterns of diagnostic evaluation / Michael J. Klein -- Lesions characterized by osteoid deposition and non-aggressive radiology / Luminita Rezeanu -- Lesions characterized by osteoid deposition and aggressive radiology located within bone / Anthony Montag -- Lesions characterized by osteoid deposition and non-aggressive radiology located on bone surface / Shi Wei -- Lesions characterized by osteoid deposition and aggressive radiology located on bone surface or within cortex / Anthony Montag -- Lesions characterized by cartilage deposition and non-aggressive/intermediate radiology / Yong-Koo Park -- Lesions characterized by cartilage deposition and aggressive radiology / Andrea T. Deyrup -- Lesions characterized by large numbers of giant cells replacing trabecular bone / Edward McCarthy -- Lesions characterized by a fibrous, spindle cell proliferation replacing trabecular bone / Frank Gannon and Benjamin Hoch -- Lesions characterized by vascular proliferation replacing trabecular bone / Wendong Yu, Sathiyamoorthy Selvarajan and Andrew E Rosenberg -- Lesions characterized by permeation of cells through trabecular bone with or without bone destruction / M. John Hicks -- Cystic lesions in bone / Yong-Koo Park -- Avascular necrosis bone infarcts, paget disease and "soft tissue tumors" of bone / Shadi A. Qasem -- Metastasis / Julie Fanburg-Smith, Michael E. Mulligan and Mark D. Murphey -- Notochordal and related lesions / Carrie Y. Inwards and Karen J. Fritchie -- Degenerative joint disease / Meera R. Hameed -- Crystalline arthropathies / Edward F. DiCarlo -- Synovial based lesions / Andrea T. Deyrup.
  • Current paediatrics -- Clinical assessment -- Social and preventative paediatrics -- Behaviour and mental health needs in childhood -- Paediatric emergencies -- Fluid replacement -- Principles of imaging in childhood -- Common orthopaedic problems -- Common paediatric surgical problems -- Inherited and metabolic problems -- Neonatal problems -- Infections in childhood -- Allergy, immunity and inflammation -- Respiratory disorders -- Cardiac disorders -- Haematological disorders and malignancies -- Seizure disorders and disorders of the nervous system -- Urinary tract disorders and hypertension -- Endocrine disorders -- Disorders of the gastrointestinal tract and hepatic disorders -- Skin disorders -- ENT, eye, and dental disorders.
  • The field of contact dermatitis is potentially frustrating given the complexity of the clinical decision-making process and the effect of false positives and negatives on patient expectations and management. Practical Patch Testing and Chemical Allergens in Contact Dermatitis outlines the most common allergens with practical tips for patch testing in a concise and algorithmic fashion. Children have different needs for patch testing and this handbook describes how to test them safely and manage their disease. Educating patients on how to avoid their irritants and allergens is also key to treatment in all types of contact dermatitis. The authors have incorporated concise reference material on where these chemicals are found and how patients can avoid them. Clinical pearls for patch testing of certain allergens are clearly outlined in this handbook to help providers avoid common pitfalls and reduce the risk of incorrect diagnoses. A frustrating clinical visit and a disappointed patient can potentially be avoided with the use of this book, and thus is is an essential reference for trainees in dermatology and all involved in the management of patients with dermatitis.
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  • Practical Pelvic Floor Ultrasonography: A Multicompartmental Approach to 2D/3D/4D Ultrasonography of Pelvic Floor provides an introduction to pelvic floor imaging, as well as a resource to be used during initial and more advanced practice. The book helps readers gain competence in performing 2D/3D/4D transperineal, and 2D/3D endovaginal / endoanal ultrasound evaluation of the pelvic floor, including anal sphincter and levator ani complex. The text also shows interested clinicians how to obtain optimal images of pelvic floor muscles and organs, how to obtain useful images of the anal canal, levator ani complex, urethra, and how to interpret clinical implications of alterations of the anatomy. In addition, emerging techniques of dynamic pelvic floor ultrasound and 3D/4D ultrasound are introduced through step by step protocols that are aimed at optimizing sonographic images. Written entirely by experts in their fields, Practical Pelvic Floor Ultrasonography: A Multicompartmental Approach to 2D/3D/4D Ultrasonography of Pelvic Floor is a comprehensive resource that will be of great value to urogynecologists, colorectal surgeons, obstetrician and gynecologists, female urologists, ultrasonographers, radiologists, physiotherapists, as well as fellows in urogynecology and colorectal surgery.
  • A practical, full-color guide with videos, Practical Perioperative Transesophageal Echocardiography, 2nd edition, by Drs. David Sidebotham, Alan F. Merry, Malcolm E. Leggett, and Mark L. Edwards, will help improve your diagnosis and monitoring of perioperative cardiac patients. Reflecting five years of new research and clinical data in TEE, the book captures the latest developments in the field, and new chapters on epiaortic and 3D echocardiography, echocardiography in the ICU, and echocardiography for adult congenital heart disease have been added. The videos demonstrate normal and pathologic findings in real time. The result is an outstanding tool for certification preparation and clinical practice. Understand the fundamental scientific principles and clinical applications of TEE in heart surgery.
  • Preface -- Introduction -- Prescription assessment -- Availability of medicines -- Oral solids -- Oral liquids -- Pulmonary -- Oropharynx -- Nose -- Ear -- Eye -- Rectal and vaginal -- Dermal -- Parenteral -- Irrigation and dialysis -- Product design -- Biopharmaceutics -- Quality risk management -- Physical chemistry -- Microbiology -- Statistics -- Radiopharmacy -- Stability -- Raw materials -- Containers -- Human resources -- Occupational health and safety -- Premises -- Equipment -- Basic operations -- Sterilisation methods -- Aseptic handling -- Quality requirements and analysis -- Documentation -- Production, Validation Quality Control -- Quality systems -- Logistics -- Instructions for the use of medicines -- Impact on Environment -- Information sources -- Index.
  • Primary Prevention of Genetic Disorders and Place of Preimplantation Diagnosis -- Approaches to Preimplantation Diagnosis -- Preimplation Diagnosis for Single-Gene Disorders -- PGD for HLA Typing -- Preimplantation Diagnosis for Chromosomal Disorders -- Clinical Outcome of Preimplantation Genetic Diagnosis -- Preimplantation Diagnosis and Establishment of Disease and Individual Specific Human Embryonic Stem Cell Lines -- Social, Ethical, and Legal Aspects.
  • Upper Extremity -- Clavicle -- Shoulder -- Treatment of non-union of clavicle fracture -- Acromioclavicular Joint Dislocation -- Diagnostic Shoulder Arthroscopy -- Acromioplasty -- Rotator cuff repair (open / arthroscopic) -- Open anterior shoulder stabilisation -- Arthroscopic Shoulder Stabilization -- Arthroscopic Capsular Release for Shoulder Stiffness -- Total shoulder arthroplasty in degenerative osteoarthritis of the shoulder -- Humerus -- Elbow -- Non-unions Of The Humeral Shaft: Open Reduction Plate Fixation And Autologous Bone Graft Augmentation -- Repair of the Ruptured Distal Biceps Tendon -- Ulnar Nerve Transposition -- Lateral Collateral Ligament Reconstruction for Posterolateral Rotatory Instability of the Elbow -- Elbow arthroscopy -- Total Elbow Arthroplasty -- Forearm -- Wrist -- Forearm Non-unions -- Wrist Arthroscopy -- Wrist Arthrodesis -- Scaphoid Non-Union -- Trapezectomy -- Carpal Tunnel Release -- Release of the First Extensor compartment at the Wrist (DeQuervain's decompression) -- Dupuytrens Fasciectomy -- Trigger Finger release -- Tendon transfers for Median Nerve Palsy -- Tendon transfers for Radial Nerve Palsy -- Tendon transfers for Ulnar Nerve Palsy -- Spine -- Cervical Spine -- Surgical technique of Anterior Cervical Discectomy and Fusion (ACDF) -- Lumbar Spine -- Microdiscectomy / Microdecompression for Intra-Spinal Intervertebral Disc Prolapses and Lateral Recess Stenosis -- Lumbar Decompression and Instrumented Fusion -- Spinal Stenosis / Decompression -- Scoliosis -- Posterior Correction of Adolescent Idiopathic Scoliosis (Principles for the posterior correction of spinal curvatures) -- Vertebro / Kyphoplasty -- Surgical technique of Vertebral Cement Augmentation (Vertebro / Kyphoplasty).
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    v. 1. Respiratory failure -- v. 2. Disease management.
  • Lung anatomy / Kevin O. Leslie and Mark R. Wick -- Optimal processing of diagnostic lung specimens / Dawn E. Jaroszewski, Robert W. Viggiano, and Kevin O. Leslie -- Computed tomography of diffuse lung diseases and solitary pulmonary nodules / Mario Maffessanti and Giorgia Dalpiaz -- Developmental and pediatric lung disease / Kirk D. Jones, Megan K. Dishop, and Thomas V. Colby -- Acute lung injury / Oi-Yee Cheung, Paolo Graziano, and Kevin O. Leslie -- Lung infections / Louis A. Rosati and Kevin O. Leslie -- Chronic diffuse lung diseases / Junya Fukuoka and Kevin O. Leslie -- Non-neoplastic pathology of the large and small airways / Mattia Barbareschi, Alberto Cavazza, and Kevin O. Leslie -- Pneumoconioses / Kelly J. Butnor and Victor L. Roggli -- Pulmonary vasculitis and pulmonary hemorrhage / William D. Travis, Kevin O. Leslie, and Mary Beth Beasley -- Pulmonary hypertension / Andrew Churg and Joanne L. Wright -- Pathology of lung transplantation / Andras Khoor and Samuel A. Yousem -- Neuroendocrine lesions of the lung / Mark R. Wick [and others] -- Sarcomas and sarcomatoid neoplasms of the lungs and pleural surfaces / Mark R. Wick [and others] -- Hematolymphoid disorders / Madeleine D. Kraus and Mark R. Wick -- Non-neuroendocrine carcinomas (excluding "sarcomatoid" carcinoma) and salivary gland analog carcinomas in the lung / Mark R. Wick [and others] -- Metastatic tumors in the lung : a practical approach to diagnosis / Stephen S. Raab [and others] -- Pseudoneoplastic lesions of the lungs and pleural surfaces / Mark R. Wick [and others] -- Benign and borderline tumors of the lungs and pleura / Mark R. Wick, Henry D. Tazelaar, and Stacey E. Mills -- Malignant and borderline mesothelial tumors of the pleura / Mark R. Wick [and others].
  • Reference dosimetry for ionizing radiation -- Relative dosimetry for MV beams -- In-vivo dosimetry -- Quality assurance and commissioning of new radiotherapy technology -- Quality assurance of radiotherapy dose calculations -- Immobilization techniques in radiotherapy -- Image guidance and localization technologies for radiotherapy -- Brachytherapy -- Proton radiotherapy -- Radiation safety and shielding in radiotherapy -- Information technology in radiation oncology -- Quality and safety improvement in radiation oncology -- Simulation for radiotherapy treatment planning -- Treatment planning and quality metrics -- The use of electrons for external beam radiotherapy -- IMRT and VMAT -- SRS and SBRT -- Clinical aspects of image guidance and localization in radiotherapy -- Respiratory motion management for external beam radiotherapy -- Intracavitary brachytherapy -- Interstitial brachytherapy -- Prostate seed implant -- Intraoperative radiotherapy (IORT) -- Special procedures -- Resource documents.
  • Embryology and normal anatomy of the kidney / Yassaman Raissian and Joseph P. Grande -- Developmental kidney disease / Carrie Phillips and Stephen Bonsib -- Renal biopsy interpretation : introduction and patterns of glomerular injury / Donna J. Lager -- Glomerular disease-primary / Edgar Fischer, Lisa A. Cerilli, and Donna J. Lager -- Glomerular diseases-secondary / Edgar Fischer, Lisa A. Cerilli, and Donna J. Lager -- Glomerular diseases-hereditary / Edgar Fischer, Lisa A. Cerilli, and Donna J. Lager -- Tubulointerstitial disease / Lois J. Arend -- Vascular diseases / Dylan V. Miller and Donna J. Lager -- Pathology of kidney transplantation / Donna J. Lager -- Optimal specimen handling and ancillary studies : renal neoplasia / Bahram Robert Oliai and Debra S. Cohen -- Pediatric renal neoplasms / Joseph D. Khoury -- Epithelial neoplasms of the renal cortex / Neil A. Abrahams and Pheroze Tamboli -- Non-epithelial neoplasms of the kidney / Steven Shen, Adebowale J. Adeniran, and Pheroze Tamboli -- Unusual renal neoplasms / Donna E. Hansel and Ming Zhou -- Renal pelvic and ureteral tumors and tumors frequently found in the renal medullary region / Neil A, Abrahams, Sonny L. Johansson, and Preetha Ramilingam.
  • Architecture of the basic physiologic recorder -- Analog and digital signals -- Signals in the frequency domain -- Filters -- Techniques for event and feature detection -- Alternative techniques for rate estimation -- Signal averaging for noise reduction -- Data compression -- Image processing -- Electrocardiography -- Intravascular and intracardiac pressure measurement -- Blood pressure and pulse oximetry -- Coronary angiography -- Echocardiography -- Nuclear cardiology: SPECT and PET -- Magnetic resonance imaging -- Computed tomography -- ECG telemetry and long term electrocardiography -- Intracardiac electrograms -- Advanced signal processing applications of the ECG: T-wave alternans, heart rate variability, and the signal averaged ECG -- Digital stethoscopes.
  • Part I. The pathologist's view -- 1. What is Atypical Junctional Melanocytic Hyperplasia? -- 2. What is Dysplastic Nevus? -- 3. What is Hypersensitivity Reaction? -- 4. What is Spongiotic Dermatitis? -- 5. What is Psoriasiform Dermatitis? -- 6. What is Lichenoid Dermatitis? -- 7. What is Granulomatous Dermatitis? -- 8. What is Dermatitis with Epidermotropism? -- 9. What is Drug Eruption? -- 10. What is Pseudolymphoma? -- Part II. The clinician's view -- 11. Reddish Facial Papules -- 12. Face infiltrated Plaques/Nodules -- 13. Patchy Alopecia -- 14. Diffuse Smooth Alopecia -- 15. Follicular Pustules of the Scalp -- 16. Scaly Scalp -- 17. Oral Erosions -- 18. Vulvar Lesions -- 19. Penile Lesions -- 20. Diffuse Leg Induration -- 21. Subcutaneous Leg Nodules -- 22. Leg Ulcers -- 23. Follicular Papules and Pustules -- Trunk -- 24. Palmoplantar Red Hyperkeratosis -- 25. Skin Folds Diffuse Rash -- 26. Exfoliative Erythroderma -- 27. Generalized Pruritus -- 28. Photo-Eruptions -- 29. Hypopigmented Patches -- 30. Pigmented Patches -- 31. Red Smooth Patches -- 32. Red Scaly Patches -- 33. Red Sloughing Patches -- 34. Red Scaly Papules -- 35. Red Non-facial Papules -- 36. Papulo-nodular Lesions with Scale and/or Crust -- 37. Edematous Smooth Plaques -- 38. Sclerotic Plaques -- 39. Diffuse Sclerosis -- 40. Purpuric Lesions -- 41. Blisters.
  • Spongiotic Dermatitis -- Erythemas with Perivascular Inflammation -- Psoriasiform and Lichenoid Dermatitis -- Vesiculobullous and Selected Pustular Disorders -- Vascular Disorders -- Nutritional Deficiency and Gastrointestinal Disease -- Panniculitis -- Connective Tissue Disorders -- Metabolic Diseases -- Degenerative Diseases -- Mucinoses -- Drugs and Physical Agents -- Noninfectious Granulomas -- Non-neoplastic Diseases of Appendages -- Pigmentation Disorders -- Disorders of Epidermal Maturation, Keratinization, and Connective Tissues -- Infectious Diseases, Including Infestations and Parasitic Diseases -- Epidermal Cysts and Tumors -- Cutaneous Appendageal Tumors -- Metastatic Tumors in the Skin -- Fibrous Tissue Tumors -- Vascular and Perivascular Proliferations of the Skin -- Tumors and Tumor-like Conditions Showing Neural, Nerve Sheath, and Adipocytic Differentiation -- Tumors of Muscle, Cartilage, and Bone -- Histiocytic Proliferations -- Disorders of Mast Cells and Plasma Cells -- Lymphoid Infiltrates, Lymphoma, and Hematopoietic Proliferations Involving the Skin -- Melanocytic Tumors.
  • Introduction : tumor classification and biologic potential / Jason L. Hornick -- Grading and reporting of soft tissue sarcomas / Jason L. Hornick -- Spindle cell tumors / Adrian Marino-Enriquez, Louis Guillou, and Jason L. Hornick -- Pediatric spindle cell tumors / Cheryl M. Coffin -- Tumors with myxoid stroma / Alessandra F. Nascimento and Jason L. Hornick -- Epithelioid and epithelial-like tumors / Essia Saiji, Louis Guillou, and Jason L. Hornick -- Pleomorphic sarcomas / J. Frans Graadt Van Roggen and Pancras C.W. Hogendoorn -- Round cell tumors / Enrique De Alava -- Biphasic tumors and tumors with mixed patterns / Alessandra F. Nascimento and Jason L. Hornick -- Tumors associated with prominent inflammatory cells / Jason L. Hornick -- Giant cell-rich tumors / Bernadette Liegl-Atzwanger and Jason L. Hornick -- Adipocytic tumors / Licia Laurino and Angelo Paolo Dei Tos -- Vascular tumors / Briana C. Gleason and Jason L. Hornick -- Cartilaginous and osseous soft tissue tumors / Andre M. Oliveira -- Cutaneous mesenchymal tumors / Thomas Brenn and Jason L. Hornick -- Mesenchymal tumors of the gastrointestinal tract / Brian P. Rubin and Jason L. Hornick -- Lower genital soft tissue tumors / Marisa R. Nucci -- Applications of molecular testing to differential diagnosis / Alexander J. Lazar.
  • Nuclear Medicine is a diagnostic modality which aims to image and in some cases quantify physiological processes in the body to highlight disease or injury. Within nuclear medicine, over the past few decades, major technological changes have occurred and concomitantly changes in the knowledge and skills required have had to evolve. One of the most significant technological changes has been the fusion of imaging technologies, to create hybrid systems such as SPECT/CT, PET/CT and PET/MR. With these changes in mind, Practical SPECT/CT in Nuclear Medicine provides a handy and informative guide to the purchase, clinical implementation and routine use of a SPECT/CT scanner. Practical SPECT/CT in Nuclear Medicine will be a valuable resource for all personnel working in nuclear medicine and it will be of particular value to trainees.
  • SQL and relational database management -- Designing databases -- Creating and filling a database -- Selecting data from the database -- Sorting data and other selection techniques -- Grouping data and reporting from it -- Joining tables for comprehensive data analysis -- Structuring queries with subqueries -- Creating and using views -- Security, transactions, performance, and integrity -- Solving business problems.
  • A volume in the new Pattern Recognition series- offers you a practical guide to solving the problems you encounter in the surgical reporting room. Drs. Arie Perry and Daniel J. Brat present diagnoses according to a pattern-based organization that guides you from a histological pattern, through the appropriate work-up, around the pitfalls, and to the best diagnosis. Lavish illustrations capture key neuropathological patterns for a full range of common and rare conditions, and a "visual index" at the beginning of the book directs you to the exact location of in-depth diagnostic guidance. No other single source delivers the practical, hands-on information you need to solve even the toughest diagnostic challenges in neuropathology.
  • This up-to-date textbook comprehensively reviews all aspects of cardiac CT and MRI and demonstrates the value of these techniques in clinical practice. A wide range of applications are considered, including imaging of atherosclerotic and non-atherosclerotic coronary artery disease, coronary revascularization, ischemic heart disease, non-ischemic cardiomyopathy, valvular heart disease, cardiac tumors, and pericardial disease. The numerous high-quality images illustrate how to interpret cardiac CT and MRI correctly for the purposes of diagnosis, treatment planning, and follow-up. Helpful summarizing sections in every chapter will facilitate rapid retrieval of information. This book will be of great value to radiologists and cardiologists seeking a reliable guide to the optimal use of cardiac CT and MRI in real clinical situations. An additional feature is the provision of QR codes allowing internet access to references, further figures, and motion pictures. The reader will be able to enjoy this book using a smartphone or tablet PC.
  • Epidemiology of chronic pain in children and adolescents -- Pain disorder: a biopsychosocial disease -- Diagnostics of chronic pain in children and adolescents -- the basics of treating pain disorders in children and adolescents -- When to decide on inpatient pain therapy? -- Pain therapy in childhood and adolescent chronic pain -- Specifics of pain therapy in children with mental disorders, severe somantic disease, or psychosocial stress factors -- Is it all worthwhile? - Effectiveness in intensive interdisciplinary pain treatment -- Diagnostic tools.
  • Features original research on the basic science of ultrasound and explores all aspects of the subject, beginning with the physical science of ultrasound and continuing through clinical applications in urology.
  • Embryology for Urologists -- Gross and Laparoscopic Anatomy of the Upper Urinary Tract and Retroperitoneum -- Gross and Laparoscopic Anatomy of the Lower Urinary Tract and Pelvis -- Anatomy of the Male Reproductive System -- Imaging of the Upper Tracts -- Principles of Bacterial Urinary Tract Infections and Antimicrobials -- An Overview of Renal Physiology -- Ureteral Physiology and Pharmacology -- Physiology and Pharmacology of the Bladder -- Pharmacology of Sexual Function -- Metabolic Evaluation and Medical Management of Stone Disease -- Molecular Biology for Urologists -- Chemotherapeutic Agents for Urologic Oncology -- Tumor and Transplant Immunology -- Pathophysiology of Renal Obstruction -- Pathophysiology of Lower Urinary Tract Obstruction -- Urologic Endocrinology -- Physiology and Pharmacology of the Prostate -- Wound Healing and Principles of Plastic Surgery -- Overview of the Evaluation of Lower Urinary Tract Dysfunction -- Urologic Instrumentation: Endoscopes and Lasers -- Prostatitis and Male Chronic Pelvic Pain Syndrome -- Disorders of Scrotal Contents: Orchitis, Epididymitis, Testicular Torsion, Torsion of the Appendages, and Fournier's Gangrene -- Nonbacterial Infections of the Genitourinary Tract -- Sexually Transmitted Infections -- Hematuria: Evaluation and Management -- Benign Prostatic Hyperplasia (BPH) -- Practical Guidelines for the Treatment of Erectile Dysfunction and Peyronie's Disease -- Premature Ejaculation -- The Role of Interventional Management for Urinary Tract Calculi -- Current Concepts of Anterior Urethral Pathology: Management and Future Directions -- Urinary Incontinence -- Neurogenic Bladder -- Pelvic Prolapse -- Urinary Tract Fistula -- Urologic Trauma -- Bladder Cancer -- Prostate Cancer -- The Management of Testis Cancer.
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  • Basic course -- Basic principles -- Examination technique: historical and current -- BI-RADS for ultrasound -- Sonographic anatomy of the breast and axilla -- Standard protocol for breast ultrasound examinations -- Intermediate course -- Fibrocystic change -- Cysts and intracystic tumors -- Breast implants -- Abscesses -- Benign solid tumors -- Scars: the treated breast -- Carcinoma -- Lymph nodes -- Advanced course -- Interventional ultrasound -- Preoperative staging -- Screening -- Follow-up and recurrence -- Three-dimensional, extended field of view ultrasound, and real-time compound scanning -- Doppler ultrasound -- Breast ultrasound review questions.
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    Part four: Valvular heart disease -- Quantitation of valvular regurgitation / Judy Hung -- Timing of intervention for chronic valve regurgitation: the role of echocardiography / Catherine M. Otto -- Intraoperative echocardiography in mitral valve repair / William J. Stewart and Brian P. Griffin -- Echocardiography in the patient undergoing catheter ballon mitral valvuloplasty: patient selection, hemodynamic results, complications, and log-term outcome / Bernard Iung and Alec Vahanian -- Clinical decision making in patients with endocarditis: the role of echocardiography / Christopher H. Cabell -- Aortic stenosis: echocardiographic evaluation of disease severity, disease progression, and the role of echocardiography in clinical decision making / Raphael Rosenhek -- Fluid dynamics of prosthetic valves / Ajit P. Yoganathan and Brandon R. Travis -- Echocardiographic recognition and quantitation of prosthetic valve dysfunction / Miguel Zabalgoitia -- Echocardiographic recognition of unusual complications after surgery on the great vessels and cardiac valves / William A. Zoghbi -- Part five: Cardiomyopathies and pericardial disease -- Doppler echocardiography in heart failure and cardiac resynchronization / Martin St. John Sutton -- Echocardiography in the evaluation and management of patients with hypertrophic cardiomyopathy / Anna Woo, E. Douglas Wigle, and Harry Rakowski -- Restrictive cardiomyopathy: diagnosis and prognostic implications / Tasneem Z. Naqvi -- Pericardial disease / Brad I. Munt, Robert R. Moss, and Christopher R. Thompson -- End-stage heart failure: ventricular assist devices and the posttransplant patient / Audrey H. Wu. Part one: Advanced echocardiographic techniques -- Transesophageal echocardiography / Ian G. Burwash and Kwan-Leung Chan -- Monitoring ventricular function in the operating room: impact on clinical outcome / Donald C. Oxorn -- Contrast ultrasound imaging: methods, analysis, and applications / Thomas R. Porter and Feng Xie -- Three-dimensional echocardiography / Michael H. Picard -- Tissue doppler and speckle tracking echocardiography / Otto A. Smiseth and Thor Edvardsen -- Intracardiac echocardiography / Thomas Bartel ... [et al.] -- Intravascular ultrasound: principles and clinical applications / Neil J. Weissman and Gary S. Mintz -- Hand-carried ultrasound / Martin E. Goldman and Lori B. Croft -- Part two: The left ventricle -- Quantitative evaluation of left ventricular structure, wall stress, and systolic function / Gerard P. Aurigemma and William H. Gaasch -- Ventricular shape and function / Florence H. Sheehan -- Assessment of diastolic function by echocardiography / Milind Y. Desai and Allan L. Klein -- Echocardiographic digital image processing and approaches to automated border detection / Johan G. Bosch -- Part three: Ischemic heart disease -- The role of echocardiographic evaluation in patients presenting with acute chest pain in the emergency room / Sarah Weeks and Kirsten E. Fleischmann -- Echocardiography in the coronary care unit: management of acute myocardial infarction, detection of complications, and prognostic implications / Ivor L. Gerber and Elyse Foster -- Exercise echocardiography / Rosario V. Freeman -- Stress echocardiography with nonexercise techniques: principles, protocols, interpretation, and clinical applications / Thomas H. Marwick -- Echocardiographic evaluation of coronary blood flow: approaches and clinical applications / Nozomi Watanabe. Part six: The pregnant patient -- Role of echocardiography in the diagnosis and management of heart disease in pregnancy / Karen K. Stout -- Part seven: Vascular and systemic diseases -- Aortic dissection and trauma: value and limitations of echocardiography / Husam H. Farah and Ann F. Bolger -- Hypertension: impact of echocardiographic data on the mechanism of hypertension, treatment, options, prognosis, and assessment of therapy / John S. Gottdiener -- Echocardiographic findings in acute and chronic respiratory disease / Paul R. Forfia and Susan E. Wiegers -- Echocardiographic findings in systemic diseases characterized by immune-mediated injury / Carlos A. Roldan -- Echocardiography in the evaluation of cardiac disease resulting from endocrinopathies, renal disease, obesity, and nutritional deficiencies / Marcus F. Stoddard -- Echocardiography in patients with inherited connective tissue disorders / Mark Lewin -- Aging changes seen on echocardiography / Michael A. Chen -- Echocardiographic evaluation of the patient with a systemic embolic event / Edmond W. Chen and Rita F. Redberg -- The role of echocardiography in atrial fibrillation and flutter / Warren J. Manning -- Part eight: Adult congenital heart disease and cardiac tumors -- General echocardiographic approach to the adult with suspected congenital heart disease / Michelle Gurvitz -- Echocardiographic evaluation of the adult with unoperated congenital heart disease / Mary Etta E. King -- Echocardiographic evaluation of the adult with postoperative congenital heart disease / John S. Child -- Cardiac tumors / Charles J. Bruce.
  • In Practice of Clinical Echocardiography, world-renowned authority Dr. Catherine M. Otto offers expert guidance on interpreting echocardiographic images and Doppler flow data and applying your findings to your daily clinical decision making. This medical reference book keeps you current on the latest advances and techniques, so you can implement the best possible approaches with your patients! Master the challenging practice of echocardiography through clear explanations of advanced concepts. Reinforce your learning with a visually rich reference that includes abundant figures and tables to supplement the text. Utilize the most promising approaches for your patients with coverage of all echocardiography modalities, including contrast and 3-D echocardiography. Zero in on the critically important information and get a quick summary for review thanks to key points at the end of each chapter and a disease-oriented assessment of echocardiographic data.
  • Since the earliest years of its development, Functional Analytic Psychotherapy (FAP) has been hailed for its clinical innovation and transformative power with clients across the range of disorders. Building on the foundations of their earlier volumes about this versatile therapy, the editors of The Practice of Functional Analytic Psychotherapy bring together noted clinicians and researchers to explain in depth how FAP can be used in conjunction with a broad spectrum of therapeutic approaches, and with diverse client populations. The hallmarks of the method, including therapist sensitivity and responding to client behavior in the moment, courage, mindfulness, acceptance, and egalitarianism, inform a wide array of interventions and strategies, among them: Integrating FAP with other treatments, including cognitive behavioral therapy, acceptance and commitment therapy, dialectical behavior therapy, behavioral activation, psychodynamic therapies, and feminist therapies. Applying FAP across cultures, nationalities, and ethnicities. Employing FAP with couples. Increasing sensitivity to and effectiveness with sexual minority clients. Modifying FAP for developmentally appropriate use with adolescents. Enhancing a team approach with severely mentally ill patients in institutional settings. Strengthening the power of interpersonal process groups. As a new tool or an enhancement to current practice, these applications of FAP will give therapists an empowering complement to their work. The Practice of Functional Analytic Psychotherapy points to compelling directions in personal growth and change on both sides of the therapeutic bond.
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    General issues in geriatric practice -- Systems of care in geriatric practice -- Prevention/rehabilitation -- Syndromes -- Neuropsychiatric disorders in geriatric practice -- Medical and surgical disorders.
  • Dr. Karim Valji, presents a comprehensive approach to help you master the latest techniques. Case studies teach you a wide range of interventional techniques, such as chemoembolization of tumors, venous access, angioplasty and stenting, and much more. With coverage of neurointerventional procedures, image-guided non-vascular and vascular procedures, and interventional oncologic procedures - plus access to the full text, case studies, images, you'll have everything you need to offer more patients a safer alternative to open surgery. Stay current on the latest developments in interventional radiology including neurointerventional procedures, image-guided non-vascular and vascular procedures, and interventional oncologic procedures. Master procedures and recognize diseases through over 100 case studies, which include images and interactive Q&A to test your knowledge. Enhance your skills in interventional radiology and reduce patient risk.
  • v. 1. Scientific basis and standard techniques -- v. 2. Advanced techniques and special applications -- v. 3. New developments in techniques and applications.
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  • Topics covered: Development of Psychotropic Drugs -- Research Methodology for Drug Trials -- Receptors -- Pharmacokinetics -- Pharmacodynamics -- Pharmacogenetics -- Anxiolytics, hypnotics -- Antipsychotic drugs -- Mood Stabilisers -- Antidepressant Drugs -- Antimuscarinic Drugs -- Antiepileptic Drugs -- Drugs Used in Movement Disorders -- Drugs Used in Substance Dependence -- Antidementia Drugs -- Adverse Reactions -- Drug Interactions -- Pharmacological Treatment of Psychiatric Disorders -- Psychopharmacology of Children -- Psychopharmocology of Elderly -- Psychopharmacology of Women -- Psychotropic Drugs in Special Patient Groups -- New Drugs -- Pharmacoeconomics -- Psycho Socio Cultural Aspects of Psychopharmacology.
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    Introduction : evidence in practice -- From formal knowledge to guided complexity -- Clinical thinking and knowledge in practice -- Growing mindlines : laying the foundations -- Growing mindlines : cultivating contextual adroitness -- The place of storytelling in knowledge sharing -- A community of clinical practice? -- Co-constructing collective mindlines -- Co-constructing clinical reality -- Conclusions and implications.
  • Defining competence and identifying target skills / Douglas W. Nangle ... [et al.] -- Social-cognitive models and skills / Cynthia A. Erdley ... [et al.] -- A conceptual basis in social learning theory / Douglas W. Nangle ... [et al.] -- Social skills and psychological adjustment / Christopher Campbell, David J. Hansen, and Douglas W. Nangle -- Assessing children and adolescents / Cynthia A. Erdley ... [et al.] -- Assessing adults / Peter J. Norton, Amie E. Grills-Taquechel, and Mona Raouf -- Social skills interventions / Ashley J. Smith ... [et al.] -- Developmental factors related to the assessment of social skills / Karen L. Bierman, Marcela M. Torres, and Hannah-Lise T. Schofield -- Diversity considerations in assessing social skills / Peter J. Norton ... [et al.] -- Anger and aggression / John E. Lochman ... [et al.] -- Social anxiety and withdrawl / Peter J. Norton -- Assessment of social skills and intellectual disability / Luc Lecavalier and Eric M. Butter -- Assessment of social skills and social competence in learners with autism spectrum disorders / Peter F. Gerhardt and Erik Mayville -- Schizophrenia / Jason E. Vogler ... [et al.] -- Assessment of social skills in substance use disorder / Lindsay S. Ham and Tracey A. Garcia -- Child measures / Agnieszka K. Serwik, Lauren J. Holleb, and Jessica Fales -- Adolescent measures / Kathryn R. Wilson, Judith A. Jordan, and Amanda M. Kras -- Adult measures / Peter J. Norton -- Appendices: A. Quick-view quides -- Child measure / Sheryle A. Moore -- B. Reprints of selected measures -- Child measures -- Adolescent measures -- Adult measures -- C. Glossary.
  • Emotional, behavioral, and neuropsychiatric conditions are common in individuals with intellectual disabilities (IDs), most notably epilepsy, aggression, self-injurious behaviors, and bipolar and other mood disorders. Despite the prevalence of such problems, there is a scarcity in the literature of reliable information on medical treatments for those with IDs. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities provides a detailed framework for prescribing for this challenging population. Featuring the most up-to-date information on factors that inform prescribing, the Guide addresses basic issues and controversies (e.g., the rift between evidence-based and personalized medicine) in treating adults with cognitive deficits. Clients' specific needs are emphasized in developing appropriate and effective pharmacological intervention for improved outcomes and quality of life. Drugs discussed in the Guide include carbamazepine, clonazepam, diazepam, ethosuximide, felbamate, gabapentin, lacosamide, lamotrigine, levetiracetam, lithium, lorazepam, oxcarbazepine, phenobarbital, phenytoin, pregabalin, primidone, rufinamide, Â tiagabine, topiramate, valproate, and zonisamide. For each of these compounds, the guidelines cover:Indications for use; relative and absolute contraindications. Assessment during treatment; therapeutic drug monitoring; warning signs and symptoms for caretakers. Dosage: administration; initial and maximum recommended dosage; modifications associated with drug-drug interactions, personal characteristics, and (where appropriate) genetic variations. Adverse drug reactions: common, relatively uncommon, and potentially lethal, plus risk of metabolic syndrome. Guidelines for discontinuation. References, tables, and drug utilization reviews. A Practitioner's Guide to Prescribing Antiepileptics and Mood Stabilizers for Adults with Intellectual Disabilities is an indispensable decision-making reference for psychiatrists, neuropsychologists, psychopharmacologists, neurologists, internists, and clinical psychologists.
  • Pragmatic disorders 2014
    This wide-ranging survey of the state of the art in clinical pragmatics includes an examination of pragmatic disorders in previously neglected populations such as juvenile offenders, children and adults with emotional and behavioural disorders, and adults with non-Alzheimer dementias. This book makes a significant contribution to the discussion of pragmatic disorders by exploring topics which have a fast-rising profile in the field. These topics include disorders in which there are both pragmatic and cognitive components, and studies of the complex impacts of pragmatic disorders such as mental health problems, educational disadvantage and social exclusion. This book also presents a critical evaluation of our current state of knowledge of pragmatic disorders. The author focuses on the lack of integration between theoretical and clinical branches of pragmatics and argues that the work of clinicians is all too often inadequately informed by theoretical frameworks. She attempts to bridge these gaps by pursuing a closer alliance of clinical and theoretical branches of pragmatics. It is claimed that this alliance represents the most promising route for the future development of the field. At once a yardstick measuring progress thus far in clinical pragmatics, and also a roadmap for future research development, this single-author volume defines where we have reached in the field, as well as where we have to go next.
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    Bd.1, 3.T., Arm.
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    Bd. 1, 2. T. Hals -- Bd. 1, 3. T. Arm -- Bd. 1, 4. T. Bein und Statik.
  • This book presents an overview of the most important current developments in the pre-analytical handling of tissue. It addresses in particular potential ways to improve the situation whereby methods employed in the pre-analytical phase ? the period from surgical removal of tissue to the start of pathological processing ? have remained essentially unchanged for decades with only modest standardization. It is examined how the pre-analytical period can be optimized, resulting not only in an increase in diagnostic quality but also in a reduction in processing time and costs. Among the key topics examined are the so-called cold ischemia time between tissue removal and fixation, the potential superiority of vacuum-based preservation over immediate formalin fixation, two-temperature fixation, molecular analysis methods, and the pre-analytics of specimens from particular tissues. Readers will find this book to be an important update that reveals the full importance of the pre-analytical phase for quality of pathological work-up.
  • Introduction -- Indications and decision making -- Pre-hospital rapid sequence intubation -- Post-intubation management -- Equipment and minimum monitoring standards -- Drugs and sedation -- Special circumstances -- Complications and adverse events -- Appendices.
  • 5050 pt. 1. Pathogenesis -- pt. 2. Model systems and clinical approaches -- pt. 3. Disease specific examples -- pt. 4. Common threads.
  • Molecular basis of breast cancer imaging -- Familial Breast Cancer and Genetic Predisposition in Breast Cancer -- Modelling the Molecular Pathology of Breast Cancer Initiation -- Molecular Pathology of Precancerous Lesions of the Breast -- Breast Cancer Stem Cells: Role in Tumor Initiation, Progression and Targeted Therapy -- Molecular Pathology of Pre-Invasive Ductal Carcinoma. -Molecular Pathology of Lobular Carcinoma Ali Sakhdari, Lloyd Hutchinson, Ediz Cosar -- Molecular Pathology of Hormone Regulation in Breast Cancer: Hormone Receptor Evaluation and Therapeutic Implications -- Molecular Pathology of HER Family of Oncogenes in Breast Cancer: HER-2 Evaluation and Role in Targeted Therapy -- Molecular Classification of Breast Cancer -- Triple Negative Breast Cancer: Subtypes with Clinical Implications -- Molecular-based Diagnostic, Prognostic and Predictive Tests in Breast Cancer -- Role of MicroRNAs in Breast Cancer -- Molecular Pathology of Fibroepithelial Neoplasms of the Breast -- Molecular Features of Mesenchymal Tumors of the Breast -- Molecular Pathology of Breast Cancer Metastasis -- The molecular pathology of chemoresistance during the therapeutic response in breast cancer -- The Molecular Pathology of Male Breast Cancer -- Specimens for Molecular Testing in Breast Cancer.
  • Introduction -- Hematolymphoid Proliferations of the Skin -- Molecular Testing in Cutaneous Mesenchymal Tumors -- Molecular Pathology of Cutaneous Adnexal Tumors -- Infectious diseases of the skin -- Application of Molecular Pathology to Cutaneous Melanocytic Lesions -- Application of Molecular Pathology to Tissue Identification in Cutaneous Pathology.
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  • This volume provides a comprehensive summary of pancreatitis and its complications, with expert recommendations on prediction and management. The text thoughtfully summarizes the current prediction models for severe acute pancreatitis, including laboratory, clinical and imaging parameters, and highlights the relative advantages and disadvantages of several of these models. Evidenced-based guidelines into medical and surgical management of both the hospitalized and discharged patient are described, with recommendations from expert authors pertaining to various clinical situations. The volume also discusses complications of acute pancreatitis and their management, including the use of cutting-edge minimally-invasive therapies. Prediction and Management of Severe Acute Pancreatitis serves as the fundamental source for those interested in and treating this disease, including practicing gastroenterologists, surgeons, radiologists, intensivists, hospitalists and pathologists.
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    An optimistic plan for reducing or eliminating many chronic diseases as well as reforming our faltering medical system, Predictive Health is a deeply knowledgeable, deeply humane proposal for how we can reallocate expenses and resources to prolong the best years of life, rather than extending the worst.
  • Predictive toxicology 2005
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  • Prefrontal cortex. 4th ed. 2008
    Chapter 1. Introduction -- Chapter 2. Anatomy of the Prefrontal Cortex -- Chapter 3. Chemical Neurotransmission -- Chapter 4. Animal Neuropsychology -- Chapter 5. Human Neuropsychology -- Chapter 6. Neurophysiology -- Chapter 7. Neuroimaging -- Chapter 8. Overview of Prefrontal Functions: The Temporal Organization of Action.
  • This unique book offers a comprehensive yet practical user-friendly guide to preimplantation genetic diagnosis (PGD). It provides understanding of and insight into the complete procedure, its recent clinical and laboratory developments and its future prospects, whilst offering an easy point of reference for patient enquiries. Concluding with perspectives on the ethical and social issues often encountered by healthcare professionals counselling patients with regards to PGD. Each chapter within Preimplantation Genetic Diagnosis in Clinical Practice is written by established authorities in their fields. An essential resource for PGD specialists and non-specialists, and for all practitioners working within the disciplines of fertility, reproductive medicine and medical genetics.
  • Premature ejaculation (PE) is a common male sexual complaint, with a self-reported prevalence of 20-30% in observational studies. Over the past 10-20 years, our understanding of PE has evolved from the initial premise that it is a psychological disorder to the current recognition of an underlying biological and probably genetic predisposition in many cases. This new understanding has been accompanied by novel approaches to the assessment and treatment of patients with PE.Premature Ejaculation is the first truly contemporary reference volume on the subject. It covers a broad range of aspects relevant to PE, including past and current definitions of the condition, the etiology of PE, its epidemiology, the impact of PE on both the patient and his partner, and the treatment of PE using pharmacotherapy and/or psychotherapy/cognitive behavioral therapy. The book is well illustrated and referenced, and the primary focus throughout is on evidence-based medicine. This timely and authoritative volume will be of great value to sexual health physicians, andrologists, endocrinologists, urologists, psychiatrists, sexologists, psychologists, and other interested healthcare professionals.
  • 1. Prenatal genetic screening and diagnostic testing -- 2. Preimplantation genetic screening and diagnostic testing -- 3. Medical reasons for pregnancy interruption: chromosomal and genetic abnormlaities -- 5. Medical reasons for pregnancy interruption: fetal reduction -- 6. Fetal pain -- 7. Giving bad and ambiguous news -- 9. Ethical issues -- 10. Religious traditions -- 11. Disability perspectives -- 12. Feminist perspectives on prenatal and preimplantation diagnosis -- 13. Critical aspects of decision-making and grieving after diagnosis of fetal anomaly -- 14. Helping patients cope with their decisions -- 15. A burden of choice: the ripple effect: parent's grief and the role of family and friends -- 16. Postscript: a patient's perspective -- Index.
  • Prenatal diagnosis 2008
    Springer Protocols
    Spectral Karyotyping (SKY): Applications in Prenatal Diagnostics / S. Mergenthaler-Gatfield, W. Holzgreve and S. Hahn -- Characterization of prenatally assessed de novo small supernumerary marker chromosomes by molecular cytogenetics / T. Liehr -- Rapid Prenatal Aneuploidy Screening by Fluorescence In Situ Hybridization (FISH) / A. Weise and T. Liehr -- Application of Multi-PRINS to Simultaneously Identify Chromosomes 18, X, and Y in Prenatal Diagnosis / M. Gadji ... [et al.] -- Prenatal Diagnosis Using Array CGH / C.D. Kashork, A. Theisen and L.G. Shaffer -- Prenatal Detection of Chromosome Aneuploidy by Quantitative Fluorescence PCR / K. Mann, E. Petek and B. Pertl -- Real-time quantitative PCR for the detection of fetal aneuploidies / B.G. Zimmermann and L. Dudarewicz -- MLPA for Prenatal Diagnosis of Commonly Occurring Aneuploidies / J. Schouten and R.J. Galjaard -- MALDI-TOF Mass Spectrometry for Trisomy Detection / D.J. Huang, M.R. Nelson and W. Holzgreve -- Rapid Detection of Fetal Mendelian Disorders: Thalassemia and Sickle Cell Syndromes / J. Traeger-Synodinos, C. Vrettou and E. Kanavakis -- Rapid detection of fetal mendalian disorders: tay-sachs disease / E. Guetta and L. Peleg -- Arrayed primer extension reaction for genotyping on oligonucleotide microarray / J. Pullat and A. Metspalu -- A Fast Microelectronic Array for Screening and Prenatal Diagnosis of beta-Thalassemia / B. Foglieni ... [et al.] -- RHD Genotyping from Maternal Plasma: Guidelines and Technical Challenges / N.D. Avent -- Isolation of Cell-Free DNA from Maternal Plasma Using Manual and Automated Systems / D.J. Huang ... [et al.] -- Fetal DNA: Strategies for Optimal Recovery / T.J. Legler ... [et al.] -- Quantification of circulatory fetal DNA in the plasma of pregnant women / B.G. Zimmermann, D.G. Maddocks and N.D. Avent -- Detection and Quantification of Fetal DNA in Maternal Plasma by Using LightCycler Technology / Y. Purwosunu, A. Sekizawa and T. Okai -- Size Fractionation of Cell-Free DNA in Maternal Plasma and Its Application in Noninvasive Detection of Fetal Single Gene Point Mutations / Y. Li, W. Holzgreve and S. Hahn -- Maldi-tof mass spectrometry for analyzing cell-free fetal DNA in maternal plasma / C. Ding -- Isolation of Cell-Free RNA from Maternal Plasma / X.Y. Zhong, W. Holzgreve and D.J. Huang -- A microarray approach for systematic identification of placental-derived RNA markers in maternal plasma / N.B. Tsui and Y.M. Lo -- A novel method to identify syncytiotrophoblast-derived RNA products representative of trisomy 21 placental RNA in maternal plasma / A.T. Go ... [et al.] -- Method for extraction of high-quantity and -quality cell-free DNA from amniotic fluid / O. Lapaire, K.L. Johnson and D.W. Bianchi -- Detection of New Screening Markers for Fetal Aneuploidies in Maternal Plasma: A Proteomic Approach / C.S. Reddy, W. Holzgreve and S. Hahn.
  • Themes and purpose -- Prenatal central nervous system development -- Low birth weight and prematurity : effects on child development outcomes -- Pre- and perinatal anoxia and hypoxia -- Prenatal infections -- Maternal chronic illness -- Nutrition -- Maternal stress -- Maternal smoking during pregnancy -- Gestational exposure to alcohol -- Maternal use of illicit drugs -- Air and water pollution -- Heavy metals and household chemicals.
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  • The latest in Springer's "Medical English" series aimed at healthcare professionals who need English for their work but do not speak English on a day-to-day basis, this book features clear advice on a variety of topics relevant to the successful preparation and delivery of scientific presentations. It also covers a wide range of situations that may develop in the context of an international congress and includes specific chapters on important issues like dealing with questions, chairing sessions, and avoiding common pitfalls in English usage and pronunciation. Although much of the information provided will be useful for scientists of all backgrounds and nationalities, the book is aimed especially at non-native English-speaking physicians and biomedical scientists. It will be an invaluable addition to the libraries of experienced presenters as well as of those just beginning their careers in international science.--Provided by publisher.
  • In concept and practice, public health casts a wide net, spanning assessment, intervention, and policy; education, prevention, and protection; public, private, and government entities. But key elements are often missing from the picture, including a clear understanding of public health and its goals by the general public, and specific public health education throughout the workforce. Public Health Practice responds to these and related challenges by elegantly summarizing the state of the field in an era of dwindling budgets, competing and overlapping services, and a shaky professional infrastructure. In keeping with public health goals set out by the CDC and other leading agencies, the author makes a real-world case for standardizing training, establishing best practices in the field, and coordinating public health systems with their healthcare counterparts. Theory, case examples, tools, and callout boxes highlight knowledge, preparation, and skills professionals need in addressing chronic issues and complex emergencies. Throughout, the emphasis is on greater competency and visibility for the profession, resulting in a more informed, healthier public. Featured in the coverage: Issues in defining the public health workforce. The state of public health education. Practicing and teaching public health: local, national, and international cases. Standardizing public health practice: benefits and challenges. Integrating public health and healthcare. The future of public health as seen from academia and the frontlines. Identifying urgent issues and providing cogent answers, Public Health Practice is a call to action for those involved in creating the next level of public health, including professors, practitioners, students, and administrators.
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    Goofball panic : barbiturates, "dangerous" and addictive drugs, and the regulation of medicine in postwar America / Nicolas Rasmussen -- Pharmacological restraints : antibiotic prescribing and the limits of physician autonomy / Scott H. Podolsky -- "Eroding the physician's control of therapy" : the post-war politics of the prescription / Dominique A. Tobbell -- Deciphering the prescription : pharmacists and the patient package insert / Elizabeth Siegel Watkins -- The Right to write : prescription and nurse practitioners / Julie A. Fairman -- The Best prescription for women's health : feminist approaches to well-woman care / Judith A. Houck -- "Safer than aspirin" : the campaign for over-the-counter oral contraceptives and emergency contraceptive pills / Heather Munro Prescott -- The Prescription as stigma : opioid pain relievers and the long walk to the pharmacy counter / Marcia L. Meldrum -- Busted for blockbusters : "scrip mills," quaalude, and prescribing power in the 1970s / David Herzberg -- The Afterlife of the prescription : the sciences of therapeutic surveillance / Jeremy A. Greene.
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    Releasing the flood waters : the development and promotion of Diuril -- Shrinking the symptom, growing the disease : hypertension after Diuril -- Finding the hidden diabetic : Orinase creates a new market -- Risk and the symptom : the trials of Orinase -- The fall and rise of a risk factor : cholesterol and its remedies -- Know your number : cholesterol and the threshold of pathology.
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    The first section of this report analyzes pharmaceutical policy in China, Korea, Japan, Thailand, Taiwan, Australia, and India. The second section focuses on two cross-cutting themes: differences in "prescribing cultures" and physician dispensing; and the challenge of balancing access to drugs with incentives for innovation -- p. [4] of cover.
  • Take the mystery out of MRI interpretation and its relationship to arthroscopy with this book by Drs. Mark D. Miller and Timothy G. Sanders. Abundantly illustrated with MR, arthroscopic, and anatomical images, this new title offers both orthopaedists and radiologists a correlated, systematic approach to diagnosis, helping you achieve accurate evaluations and ensuring that all clinically relevant structures are adequately assessed. An accompanying case-based DVD illustrates pathology and repair, with side-by-side comparisons of MRI and arthroscopic findings in the same patient. Improve diagnostic accuracy, surgical planning/decision making, and patient outcomes by seeing how to correlate MRI and arthroscopic findings. Gain an enhanced appreciation of the sensitivity and specificity of MRI as a tool in musculoskeletal diagnosis. Enhance your diagnostic skills by reviewing illustrative case studies for each major joint, examining specific MRI and arthroscopic findings and considering the range of possible diagnoses. View side-by-side comparisons of MRI and arthroscopic footage in the same patient - augmented by line illustrations that orient the arthroscopic views - by watching the videos on the bound-in DVD. Take the mystery out of MRI interpretation to assess more confidently.
  • Pressure Ulcers in the Aging Population: A Guide for Clinicians is a resource primarily aimed at physicians interested in the fundamentals of wound care. This book is written for geriatricians, internists, general practitioners, residents and fellows who treat older patients. Unlike other wound texts on the market, the book addresses the specific issues of wound prevention and management in older individuals.The text emphasizes proper documentation and elements of the team care process. There is up to date information on skin changes at the end of life and the concept of unavoidability.Chapters are written by experts in their fields and include such evolving topics as deep tissue injury and the newer support surface technologies.
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    I. Introduction -- II. Pressure ulcer incidence and prevalence by clinical settings -- III. Pressure ulcer incidence and prevalence in special populations -- IV. Special topics -- V. Appendices.
  • Extent and consequences of childhood obesity -- Developing an action plan -- A national public health priority -- Industry, advertising, media, and public education -- Local communities -- Schools -- Home -- Confronting the childhood obesity epidemic.
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    1. Introduction -- 2. What is the environment in the context of health? -- 3. What is meant by the "attributable fraction" of a risk factor? -- 4. Methods -- 5. Analysis of estimates of the environmental attributable fraction, by disease -- 6. Global results of the analysis -- 7. Conclusions -- Annex 1: WHO Member States -- Annex 2: Global statistics produced by the analysis of the environmental disease burden (Tables A2.1, A2.2 and A.2.3) -- Annex 2: Global statistics produced by the analysis of the environmental disease burden (Tables A2.4) -- References, acknowlegments, credits.
  • "Suicides are preventable. Even so, every 40 seconds a person dies by suicide somewhere in the world and many more attempt suicide. Suicides occur in all regions of the world and throughout the lifespan. Notably, among young people 15-29 years of age, suicide is the second leading cause of death globally. Suicide impacts on the most vulnerable of the world's populations and is highly prevalent in already marginalized and discriminated groups of society. It is not just a serious public health problem in developed countries; in fact, most suicides occur in low- and middle-income countries where resources and services, if they do exist, are often scarce and limited for early identification, treatment and support of people in need. These striking facts and the lack of implemented timely interventions make suicide a global public health problem that needs to be tackled imperatively. This report is the first WHO publication of its kind and brings together what is known in a convenient form so that immediate actions can be taken. The report aims to increase the awareness of the public health significance of suicide and suicide attempts and to make suicide prevention a higher priority on the global public health agenda. It aims to encourage and support countries to develop or strengthen comprehensive suicide prevention strategies in a multisectoral public health approach. For a national suicide prevention strategy, it is essential that governments assume their role of leadership, as they can bring together a multitude of stakeholders who may not otherwise collaborate. Governments are also in a unique position to develop and strengthen surveillance and to provide and disseminate data that are necessary to inform action. This report proposes practical guidance on strategic actions that governments can take on the basis of their resources and existing suicide prevention activities. In particular, there are evidence-based and low-cost interventions that are effective, even in resource-poor settings. This publication would not have been possible without the significant contributions of experts and partners from all over the world. We would like to thank them for their important work and support. The report is intended to be a resource that will allow policy-makers and other stakeholders to make suicide prevention an imperative. Only then can countries develop a timely and effective national response and, thus, lift the burden of suffering caused by suicide and suicide attempts from individuals, families, communities and society as a whole."--Preface, page 03.
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  • Biological causes of aging and age-related diseases / Suresh I.S. Rattan -- Immunity, inflammation and infections during aging : the susceptibility to infections in elderly individuals / Miriam Capri, ... [et al.] -- Progress and development in Parkinson disease therapy / Carsten R. Bjarkam and Jens C. Sørensen -- Understanding and treating Alzheimer's disease / Umesh Kumar, Alexander Roland and Stephen A. Burbidge -- Slowing down age-related muscle loss and sarcopenia / P. Noirez and G. Butler-Browne -- Pathophysiology, prevention and treatment of age-related osteoporosis in women / Moustapha Kassem and Kim Brixen -- Arthritis and its treatment / Ashit Syngle -- Recent developments in the treatment of diabetes Type 2 / Jan O. Nehlen -- Age-related cataract : management and prevention / Mayank A. Nanavaty, Abhay R. Vasavada and P.D. Gupta -- Skin aging : pathogenesis, prevention and treatment / Mary S. Jung, Kristen M. Kelly and Jerry L. McCullough -- Aging and periodontal disease / R. Suresh -- Molecular diagnosis of breast cancer / Lise Lotte Hansen -- Prostate disease in the aging male : prevention, diagnosis and treatment of prostate cancer / Anne R. Simoneau -- Human premature aging diseases : molecular biology to clinical diagnosis / Dai-Di Gan, ... [et al.] -- Protein aggregation in aging and age-related neurodegenerative disorders / Jeffrey N. Keller and Qunxing Ding -- Nutritional deficiency and its modulation in old age / Carlos K.B. Ferrari -- Dietary fats and age-related diseases / Kaustuv Bhattacharya and Suresh I.S. Rattan.
  • Anal Fissure -- Hemorrhoids -- Anal Abscesses and Fistulae -- Rectovaginal Fistulae -- Sacrococcygeal Pilonidal Sinus -- Tumors of the Rectum and Anus -- Anal Condylomata and Anorectal Stricture -- Obstructed Defecation (OD) and Related Diseases -- Fecal Incontinence -- External Rectal Prolapse.
  • Bone metastases continue to be a major cause of morbidity in cancer patients, but improved understanding of the biology of bone metastases has led to the identification of drugs that are of potential value in not only their treatment but also their prevention. This book, written by recognized experts in the field, provides a detailed overview of current knowledge on this subject.
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  • Global burden of non-transmissible chronic diseases.- A global perspective about cardiovascular diseases.- Value of primary prevention for cardiovascular diseases.- How to estimate cardiovascular risk.- Tobacco and alcohol control -- preventable risk factors.- Physical inactivity: preventable risk factor for cardiovascular diseases.- Diet and cardiovascular health: global challenges and opportunities.- Raised blood cholesterol: preventable risk factor for cardiovascular diseases.- Hypertension: primary health care approach.- Diabetes: a primary health care approach -- Risk factors in childhood and youth.- Other determinants in cardiovascular diseases: social impact, globalization and urbanization.- Genetics of cardiovascular diseases.- Cardiovascular diseases in women: an update -- Rheumatic heart disease: a neglected condition.- Chagas disease.- Prevention and control of cardiovascular: policies, strategies and prevention.- Prevention and control of cardiovascular in low income countries.- Prevention and Control of cardiovascular: What Works?.- Prevention and control of cardiovascular: integrated and complementary strategies.- Post-traumatic stress disorders and cardiovascular diseases.- Individual interventions for prevention and control of cardiovascular diseases.- Social mobilization on prevention and control of cardiovascular diseases.- Frugal Innovation: Solutions for Sustainable Global Cardiovascular Health.- Atrial fibrillation and stroke prevention.- A global alliance for cardiovascular diseases prevention in clinical practice.- Priority areas for cardiovascular research.- Evidence for preventing cardiovascular diseases.
  • The cholesterol hypothesis--its basis and its faults -- Association of high total cholesterol with coronary heart disease mortality differs among subject populations--Familial hypercholesterolemia as a key concept -- Cancer and all-cause mortalities are lower in the higher total cholesterol groups among general populations -- Pleiotropic effects of statins in the prevention of coronary heart disease--potential side effects -- Objective measures of pathology of coronary heart disease -- [omega]3 fatty acids effectively prevent coronary heart disease and other late-onset diseases--the excessive linoleic acid syndrome -- Why isn't the causal relationship between linoleic acid and mortalities from coronary heart disease and stroke revealed by clinical studies? -- Mechanisms by which dietary fats affect coronary heart disease mortality -- Cancers common in the USA are stimulated by [omega]6 fatty acids and large amounts of animal fats, but suppressed by [omega]3 fatty acids and cholesterol -- New directions of lipid nutrition for the primary and secondary prevention of coronary heart disease and other late-onset diseases.
  • Prevention of Major Depression: A Global Priority -- The Framework for Prevention -- Social and Behavioral Risk Factors for Late-life Depression -- Prevention of Depression in Medical Conditions -- Vascular Depression and the Role of Neuroimaging and Biomarkers -- Measurement and Assessment in Late-life Depression -- Applications I: Indicated Prevention -- Applications II: Selective and Universal Prevention of Late-life Depression -- Health Policy and Economic Aspects of Late-life Depression Prevention -- Depression among Blacks during Late Life: Examining Within Group Variations -- Global Priorities and Possibilities.
  • Treatment tolerance is a challenge for most cancer patients, and it is therefore essential that healthcare professionals (HCPs) are quick to recognize adverse events and implement management strategies to address them. Prevention of Nausea and Vomiting in Cancer Patients provides comprehensive guidance on managing nausea and vomiting, which are common and often severe adverse events experienced by patients receiving chemotherapy and radiotherapy. The book refers to the latest American Society of Clinical Oncology (ASCO), European Society of Medical Oncology (ESMO), and Multinational Association for Supportive Care in Cancer (MASCC) guidelines and will be a useful resource for oncologists, oncology fellows, general physicians, and other HCPs wishing to learn more about the effective management of chemotherapy-and radiotherapy-induced nausea and vomiting in cancer patients.
  • Overview of the topic -- Meaning of SPC -- Importance of SPC -- Framework and methodology -- Lymphomas -- Leukemias -- Breast cancer (female) -- Lung cancer -- Cancers of the head and neck -- Gastrointestinal cancers -- Genitourinary cancers -- Gynecologic cancers -- Skin cancers -- Pediatric cancers -- Summary of significant SPC associations -- Population health priorities.
  • Prevention of stroke 2002
  • Prevention of Type 2 Diabetes; from Science to Therapies / Emily Jane Gallagher and Derek LeRoith -- Pathophysiology: Loss of [beta]-Cell Function / Ele Ferrannini and Andrea Mari -- Pathophysiology of Insulin Resistance: Implications for Prevention / Shamsa Ali and Vivian A. Fonseca -- Epidemiology Including Youth Through Adulthood and Socioeconomic Impact / Helen Looker -- Prediabetes Genes in Pima and Amish / Leslie J. Baier -- Predicting Diabetes / Rachel Dankner and Jesse Roth -- Screening for Prediabetes and Diabetes / Amir Tirosh -- Neuropathy in Prediabetes and the Metabolic Syndrome / Aaron I. Vinik and Marie-Laure Nevoret -- Interventional Trials to Prevent Diabetes: Diabetes Prevention Program / Vanita R. Aroda and Robert E. Ratner -- Decreasing Postprandial Plasma Glucose Using an [alpha]-Glucosidase Inhibitor in Subjects with IGT for the Prevention of Type 2 Diabetes Mellitus: The STOP-NIDDM Trial / Jean-Louis Chiasson, Markku Laakso and Markolf Hanefeld -- Da Qing, Finnish DPP, Tripod, and Dream: Lifestyle and Thiazolidinediones in the Prevention of Diabetes / Mariela Glandt and Zachary Bloomgarden -- Community Approaches to Diabetes Prevention / Ann Albright and David Williamson -- Think Locally, Act Locally, Extend Globally: Diabetes Prevention Through Partnerships with Local Communities / Carol R. Horowitz and Brett Ives -- Global Challenge in Diabetes Prevention from Practice to Public Health / Peter E. H. Schwarz.
  • Introduction -- Preventive and predictive genetics: a perspective -- Roadmap to drug development enabled by pharmacogenetics -- Pharmacogenetics, statistical considerations -- Pharmacokinetics and pharmacogenetics: bringing the magic bullet closer to reality -- Pharmacogenetics of adverse drug reactions -- Pharmacogenomics for haemoglobinopathies therapeutics -- Pharmacogenetics of neurodegenerative disorders -- Pharmacogenetics of asthma -- Pharmacogenetics and antineoplastic therapies -- Pharmacogenetics of coumarin anticoagulant therapy -- Implementation of genomic medicine: tools and challenges -- Ethical considerations in the genomic era -- Index.
  • A new Companion to Braunwald's Heart Disease - addresses the prevention and risk stratification of cardiovascular disease so that you can delay the onset of disease and moderate the effects and complications. Drs. Roger Blumenthal, JoAnne Foody, and Nathan Wong discuss the full range of relevant considerations, including the epidemiology of heart disease, risk assessment, risk factors, multiple risk factor-based prevention strategies, and developments in genetics and personalized medicine.The most authoritative and relevant reference on Prevention of Cardiovascular Diseases is now available!
  • The unstable plaque: implications and opportunities for prevention / JoAnne Micale Foody and Steven E. Nissen -- Endothelial function and insights for prevention / Eric H. Lieberman, Margarita R. Garces, and Francisco Lopez-Jiminez -- Inflammation and infection in coronary artery disease / Michael A. Lauer -- Low-density lipoprotein cholesterol and coronary artery disease: clinical evidence and clinical implications / JoAnne Micale Foody -- High-density lipoprotein cholesterol, triglycerides, and coronary artery disease: clinical evidence and clinical implications / JoAnne Micale Foody -- Management of hypertension: implications of JNC 7 / Gregory M. Singer and John F. Setaro -- Diabetes mellitus, hyperinsulinemia, and coronary artery disease / Byron J. Hoogwerf -- Exercise in the prevention of coronary artery disease / Gordon G. Blackburn -- Obesity and coronary artery disease: implications and interventions / Kristine Napier -- Tobacco as a cardiovascular risk factor / Robyn Bergman Buchsbaum and Jeffrey Craig Buchsbaum -- The implications of mental stress for cardiovascular disease / Brendon L. Graeber ... [et al.] -- Women and coronary artery disease / JoAnne Micale Foody -- Subclinical atherosclerosis / Rahman Shah and JoAnne Micale Foody -- Exercise testing and risk assessment / Christopher R. Cole and Michael S. Lauer -- Aspirin and antiplatelet agents in the prevention of complications of coronary artery disease / Andrew I. MacKinnon, Scott A. Moore, and Steven R. Steinhubl -- Pharmacoeconomics of cardiovascular medicine / Melanie Oates, William F. McGhan, and Ron Corey -- Innovative models for the delivery of preventive cardiovascular care / Joseph P. Frolkis.
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    1. Meeting the challenge -- -- 2. Situation analysis -- -- 3. Preventive chemotherapy and its role in the control of helminthiasis -- 3.1 Aim and rationale -- 3.2 Ancillary benefits and advantages of preventive chemotherapy -- -- 4. WHO-recommended drugs: alone and in combination -- -- 5. Preventive chemotherapy: best practice -- 5.1 Eligibility and ineligibility for treatment -- 5.2 Safety and adverse reactions -- 5.2.1 Safety of drug combinations for treatment of helminth infections -- 5.2.2 Safety in pregnancy -- 5.3 Drug quality -- 5.4 Programme implementation -- 5.4.1 Drug delivery and incorporation into established and novel programmes -- 5.4.2 Implementation charts--how to intervene -- 5.5 Different age groups and special risk groups in preventive chemotherapy -- 5.5.1 Preschool children (aged 1-5 years) -- 5.5.2 School-age children (aged 6-15 years) and adults (aged >15 years) -- 5.5.3 Adolescent girls, women of reproductive age and pregnant women -- 5.6 Problems caused by concurrent infections -- -- 6. Measuring and monitoring during preventive chemotherapy -- 6.1 Coverage -- 6.2 Evaluation of impact on morbidity and transmission -- 6.3 Threat of drug resistance and monitoring of drug efficacy -- -- Annexes -- I. Occurrence of lymphatic filariasis, onchocerciasis, schistosomiasis, soil-transmitted helminthiasis and loiasis in countries and territories where preventive chemotherapy interventions may need to be implemented -- II. Rapid assessment and decision charts for schistosomiasis and soil-transmitted helminthiasis -- III. Standardized form for recording serious adverse experiences -- IV. Drug supply, recommended dosages and dose poles -- V. Coverage forms -- VI. Disease-specific information
  • Stress, relaxation, and general well-being -- Smoking, obesity/nutrition, sun and the skin -- Raising awareness on the health literacy epidemic -- Domestic violence, abuse, and neglect: indicators for dermatology -- Working with other healthcare providers -- The future of dermatological therapy and preventive dermatology -- Prevention of drug reactions and allergies in dermatology -- Xerosis and stasis dermatitis -- Photoprotection -- Biologics -- Occupational dermatology -- Diagnosis and prevention of bullous diseases -- Diagnosis and prevention of atopic eczema -- Prevention of psoriasis -- Sports dermatology: prevention -- Prevention of cosmetic problems -- Nutrition, vitamins, and supplements -- Vaccines for viral diseases -- Prevention of sexually transmitted diseases from office to globe -- Current vaccination in dermatology -- Prevention of skin infections -- Wound prevention -- Prevention of surgical complications -- Prevention of keloids. Appendices: Patient handouts: preventive dermatology topics -- Skin performance assessment questionnaire.
  • Since a couple of decades, the notion of a precautionary principle plays a central and increasingly influential role in international as well as national policy and regulation regarding the environment and the use of technology. Urging society to take action in the face of potential risks of human activities in these areas, the recent focus on climate change has further sharpened the importance of this idea. However, the idea of a precautionary principle has also been problematised and criticised by scientists, scholars and policy activists, and been accused of almost every intellectual sin imaginable: unclarity, impracticality, arbitrariness and moral as well as political unsoundness. In that light, the very idea of precaution as an ideal for policy making rather comes out as a dead end. On the basis of these contrasting starting points, Christian Munthe undertakes an innovative, in-depth philosophical analysis of what the idea of a precautionary principle is and should be about. A novel theory of the ethics of imposing risks is developed and used as a foundation for defending the idea of precaution in environmental and technological policy making against its critics, while at the same time avoiding a number of identified flaws. The theory is shown to have far-reaching consequences for areas such as bio-, information- and nuclear technology, and global environmental policy in areas such as climate change. The author argues that, while the price we pay for precaution must not be too high, we have to be prepared to pay it in order to act ethically defensible. A number of practical suggestions for precautionary regulation and policy making are made on the basis of this, and some challenges to basic ethical theory as well as consumerist societies, the global political order and liberal democracy are identified.
  • 1. Connecting the inner ear to the central auditory system: molecular development and characteristics of the primary auditory neurons and their network -- 2. Early development of the spiral ganglion -- 3. Neurotrophic factor function during ear development: expression changes define critical phases for neuronal viability -- 4. The electrophysiological signature of spiral ganglion neurons -- 5. The ribbon synapse between type I spiral ganglion neurons and inner hair cells -- 6. Central projections of spiral ganglion neurons -- 7. The spiral ganglion in an out-of-body experience: a brief history of in vitro studies of the spiral ganglion -- 8. Loss, degeneration, and preservation fo the spiral ganglion neurons and their processes -- 9. Stem cells for the replacement of auditory neurons.
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  • Primary care is complex, unpredictable, and requires a biopsychosocial orientation. An indispensable teaching resource, Primary Care Interviewing: Learning Through Role Play thoroughly details how to use role play to teach the basics and more complex aspects of medical interviewing skills to trainee clinicians. Role playing is ideally suited to teach clinicians how to interview and relate to patients, and this unique and concise title includes not only sample role plays and dialog but also a wealth of accompanying online video role plays to enhance the learning process.
  • Community-acquired pneumonia : a common illness that continues to evolve / Thomas J. Marrie -- Etiology and pathophysiology / Jennie Johnstone & Mark Loeb -- Symptoms, diagnosis and prognosis / Werner Albrich, Philipp Schuetz, Beat Müller & Mirjam Christ-Crain -- Community-acquired pneumonia in children / Matti Korppi -- Primary care treatment in adults : outpatients / Michael R. Jacobs & Thomas M. File -- Primary-care treatment in adults : hospitalization / Charles Feldman & Ronald Anderson -- Complications / Juan F. Fernandez, Bo Chen & Marcos I. Restrepo -- Prevention of lower respiratory tract infections via vaccination / David R.P. Guay -- Emerging drug resistance and future directions of CAP management / Donald E. Low.
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    1. Principles of primary care --2. Systemic problems --3. Cardiovascular problems --4. Respiratory problems --5. Gastrointestinal problems --6. Hematologic and oncologic problems --7. Endocrinologic problems --8. Gynecologic problems --9. Genitourinary problems --10. Musculoskeletal problems --11. Neurologic problems --12. Dematologic problems --13. Ophthalmologic problems --14. Ear, nose, and throat problems --15. Psychiatric problems --16. Allied fields.
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  • Comprehensive reference that covers both the pathophysiology and epidemiology of problems occurring in premature babies in the Neonatal Intensive Care Unit, and the management of these problems once the infant has been released from the NICU to a community practice. The book emphasizes specific diseases that affect premature infants and focuses on two primary categories: background and management in the NICU, and management of specific illnesses after discharge from the NICU.
  • "This book is a user-friendly guide to procedures in women's health for primary care physicians. The spectrum of office-based procedures is covered, including pelvic examination; contraceptive procedures; and dermatologic procedures, both cosmetic and non-cosmetic. Key information is readily accessible, and chapters present indications, risks, and decision trees for guidance on how to proceed based on results. Procedures are detailed step-by-step.The accompanying illustrations add clarity, and imaging is provided where appropriate. Case studies facilitate the integration of procedures into clinical practice. Coding and reimbursement are outlined as well. This practical book also features patient handouts that explain procedures and address complications. Lists of disposable and non-disposable supplies are ideal references for assistants. Physicians, residents, and other providers of women's health care will find this text an indispensable aid for learning new procedures and improving existing skills"--Provided by publisher.
  • Diagnosing and treating sleep disorders have been added to the primary care physician's list of ever-growing responsibilities. This added expectation presents many risks since sleep medicine is rarely included in the curricula of medical schools or in non-sleep medicine residency training. The second edition to Primary Care Sleep Medicine fulfills the need of a comprehensive text assisting the physician with up-to-date information on the sleep medicine field. This updated volume represents the cutting edge of knowledge for the field, with summaries of the latest research on new diagnostic tests, medications and therapies; useful for any physician considering specialization in the field. Chapters are authored by leaders in the field of sleep medicine with an understanding of the primary care environment. Practical and comprehensive, this text is an invaluable resource for physicians and allied health professionals.
  • Integrating behavioral health into primary care medical settings has been shown to produce: healthier patients; medical savings; higher patient satisfaction; and, increased physician satisfaction. This book provides practice guidelines and other associated practical tools for the practicing integrative care behavioral health professional.
  • Epidemiology and risk factors -- Molecular pathogenesis -- Cellular origins of malignant glioma: the cancer stem cell polemic -- Principles of supportive care -- Principles of clinical trial design and response assessment -- Complications of therapy -- Neuropsychological function and quality of life -- Low-grade gliomas -- High-grade astrocytomas -- Anaplastic oligodendrogliomas and mixed gliomas -- Ependymomas -- Uncommon gliomas in adults: brainstem gliomas, pilocytic astrocytomas, and pleomorphic xanthastrocytomas -- Pediatric tumors -- Primary central nervous system lymphoma -- Meningiomas -- Pituitary adenomas -- Vestibular schwannomas -- Medulloblastomas -- Pineal region tumors -- Genetic syndromes -- Rare tumors -- Spinal tumors.
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  • Primary cilia 2009
  • Concepts, Challenges and Perspectives in Cancer Research / Jianren Gu, Wenxin Qin, Zhigang Zhang -- Systemic Dysregulation in the Development of Hepatocellular Carcinoma / Jianren Gu, Xianghuo He, Zhenfeng Zhang, Weijie Guo, Zhiao Chen -- Genomics of Hepatocellular Carcinoma / Chunming Wong, Irene Oi Lin Ng -- Biomarkers of Hepatocellular Carcinoma / Hongyang Wang, Wen Wen -- Metabonomics of Hepatocellular Carcinoma / Peiyuan Yin, Guowang Xu -- Signal Transduction of Hepatocellular Carcinoma / Hongyang Wang, Yaqin He, Wen Yang -- Cancer Stem Cells of Hepatocellular Carcinoma / Gangming Zou, Jinjun Li, Jianren Gu -- Immunology of Liver / Zhigang Tian, Yongyan Chen -- Immunosuppresssion and Immune Escape in Liver Cancer / Qingqing Wang, Xuetao Cao -- Immunotherapy of Hepatocellular Carcinoma / Zhinan Chen, Huijie Bian, Jinliang Xing, Jianli Jiang, Yu Li -- Chemoprevention of Hepatic Cancer in Aflatoxin Endemic Areas / Thomas W. Kensler, John D. Groopman, Patricia A. Egner -- Metastasis of Hepatic Cancer / Zhaoyou Tang -- Integrated Treatment of Hepatic Cancer / Mengchao Wu, Feng Shen, Jiamei Yang, Weiping Zhou, Yiqun Yan -- Liver Transplantation for Hepatocellular Carcinoma / Shusen Zheng.
  • Hepatocellular Carcinoma: Etiology and Natural History / Tinsay A. Woreta and James P. Hamilton -- Surveillance for Hepatocellular Carcinoma / Reezwana Chowdhury and Rohit Satoskar -- Radiologic Diagnosis of Hepatocellular Carcinoma / Stephen Thomas and Aytekin Oto -- Pathology of Hepatocellular Carcinoma / Shriram Jakate and Deborah Giusto -- Differential Diagnosis of Focal Hepatic Lesions / Russell N. Wesson and Andrew M. Cameron -- Paraneoplastic Syndromes / Po-Hung Chen and Ayman Koteish -- Hepatocellular Carcinoma in Children / Christiane Sokollik, Abha Gupta and Simon C. Ling -- Staging of Hepatocellular Carcinoma / Chalermrat Bunchorntavakul, Maarouf Hoteit and K. Rajender Reddy -- Liver Anatomy and Function in the Planning of Hepatic Interventions / Nicholas N. Nissen and Alagappan Annamalai -- Treatment of HCC: Resection, Local-Regional Therapy, Systemic Therapy, and Liver Transplantation / Nate Susnow, Talia B. Baker and Laura Kulik -- Recurrence: Prevention and Management / Natasha Chandok and Paul Marotta -- The Impact of Treating Chronic Liver Diseases on Hepatocellular Carcinoma Prevention / Narayan Dharel and Daryl T. Lau -- Emerging Serum Biomarkers of HCC / Anjana A. Pillai and Claus J. Fimmel -- Emerging Therapies for Hepatocellular Carcinoma / Renumathy Dhanasekaran and Roniel Cabrera.
  • Infant nutrition and primary prevention: current and future perspectives / Lucas, A.; Sampson, H.A. -- Nutritional interventions in infancy and childhood for prevention of atherosclerosis and the metabolic syndrome / Singhal, A. -- Childhood obesity: potential mechanisms for the development of an epidemic / Maffeis, C. -- Prenatal and postnatal development of obesity: primary prevention trials and observational studies / Kroke, A. -- Childhood diabetes mellitus with emphasis on perinatal factors / Laron, Z. -- The gut microbiota and potential health effects of intervention / Björkstén, B. -- The relationship of breastfeeding to the development of atopic disorders / Zeiger, R.S., Friedman, N.J -- Prevention of atopy and allergic disease: type of infant formula / Sampson, H.A. -- Introduction of solid foods / von Berg, A. -- Osteoporosis: is primary prevention possible? / Fewtrell, M. -- Nutrition and cancer prevention: targets, strategies, and the importance of early life interventions / Hursting, S.D. ... [et al.] -- Long-chain polyunsaturated fatty acids in early life: effects on multiple health outcomes : a critical review of current status, gaps and knowledge / Fewtrell, M.S -- Perinatal PUFA intake affects leptin and oral tolerance in neonatal rats and possibly immunoreactivity in intrauterine growth retardation in man / Hanson, L.A. ... [et al.] -- The crucial role of dietary n-6 polyunsaturated fatty acids in excessive adipose tissue development: relationship to childhood obesity / Massiera, F.; Guesnet, P.; Ailhaud, G. -- -Omics for prevention: gene, protein and metabolite profiling to better understand individual disposition to disease / Affolter, M. ... [et al.].
  • 1 History of retinal detachment surgery / Kourous A. Rezaei, Gary W. Abrams -- 2 Prophylaxis in fellow eye of primary retinal detachment: what not to do and what to do / Normal Byer -- 3 Encircling operation with drainage for primary retinal detachment / Hermann D. Schubert -- 4 Pneumatic retinopexy for primary retinal detachment / Eric R. Holz, William F. Mieler -- 5 Vitrectomy for the primary management of retinal detachment / Stanley Chang -- 6 Minimal segmental buckling with sponges and balloons for primary retinal detachment / Ingrid Kreissig -- 7 Pharmacological approaches to improve surgical outcomes after retinal reattachment surgery / Mark S. Blumenkranz -- 8 Systematic review of efficacy and safety of surgery for primary retinal detachment / Harvey Lincoff, Anne Lincoff, Marcin Stopa -- 9 Repair of primary retinal detachment: the present state of the art and how it came about / Ingrid Kreissig, Harvey Lincoff -- 10 Retinal detachment repair: outlook for the future / William R. Freeman -- Subject index.
  • Biogeography and primates : a review / Shawn M. Lehman, John G. Fleagle -- Nested distribution patterns and the historical biogeography of the primates of Guyana / S.M. Lehman -- Genetic evidence on the historical biogeography of Central American howler monkeys / Julie A. Ellsworth, Guy A. Hoelzer -- Ecological biogeography of primates in Guyana / S.M. Lehman ... [et al.] -- Contrasting phylogeographic histories of chimpanzees in Nigeria and Cameroon : a multi-locus genetic analysis / M. Katherine Gonder, Todd R. Disotell -- Geographic variation in Savanna baboon (Papio) ecology and its taxonomic and evolutionary implications / Jason M. Kamilar -- Biogeography and evolution of the Cercocebus-Mandrillus clade : evidence from the face / W. Scott McGraw, John G. Fleagle -- Mouse lemur phylogeography revises a model of ecogeographic constraint in Madagascar / Anne D. Yoder, Kellie L. Heckman -- Abiotic and biotic factors as predictors of species richness on Madagascar / Nancy J. Stevens, Patrick M. O'Connor -- The geography of mammals and rivers in mainland Southeast Asia / Erik Meijaard, Colin Peter Groves -- Primate biogeography and ecology on the Sunda Shelf islands : a paleontological and zooarchaeological perspective / Terry Harrison, John Krigbaum, Jessica Manser -- The biogeography of primate evolution : the role of plate tectonics, climate and chance / John G. Fleagle, Christopher C. Gilbert -- Biogeographic origins of primate higher taxa / Christopher P. Heesy, Nancy J. Stevens, Karen E. Samonds -- Mammalian biogeography and anthropoid origins / K. Christopher Beard -- Continental paleobiogeography as phylogenetic evidence / James B. Rossie, Erik R. Seiffert.
  • Menopause and reproductive senescence in comparative context / Erwin, J.M ; Hof, P.R. -- Aging in wild female lemurs: sustained fertility with increased infant mortality / Wright, P. ... [et al.] -- Reproduction and aging in marmosets and tamarins / Tardif, S.D. ... [et al.] -- Aging Cebidae / Williams, L. -- Heterogeneity of reproductive aging in free-ranging female rhesus macaques / Johnson, R.L. ; Kapsalis, E. -- Reproductive and behavioral characteristics of aging in female Asian colobines / Borries, C. ; Koenig, A. -- Reproductive aging in female chimpanzees (Pan troglodytes) / Videan, E.N. ... [et al.] -- Perimenopause and menopause: documenting life changes in aging female gorillas / Atsalis, S. ; Margulis, S.W. -- Reproductive life history traits of female orangutans (Pongo spp.) / Shumaker, R.W. ; Wich, S.A. ; Perkins, L. -- Origins and health consequences of stress-induced ovarian dysfunction / Kaplan, J.R. -- Primate reproductive aging: from lemurs to humans / Atsalis, S. ; Margulis, S.W.
  • Taxonomy and biogeography of the primates of western Uganda / Colin Groves -- Factors influencing variation in the population densities of Colobus guereza within selectively logged forest at the Budongo Reserve : the importance of lianas during a subsistence diet / Graham Anthony Preece -- How does the golden monkey of the Virungas cope in a fruit-scarce environment? / Dennis Twinomugish ... [et al.] -- The diet of olive baboons (Papio anubis) in Budongo Forest Reserve, Uganda / Adam Alberts Okecha and Nicholas E. Newton-Fisher -- Aspects of diet, foraging, and seed predation in Ugandan forest baboons / James D. Paterson -- The interaction of hormones with ecological factors in male Budongo Forest chimpanzees / Sally B. Seraphin, Patricia L. Whitten, and Vernon Reynolds -- The role of diet in self-medication among chimpanzees in the Sonso and Kanyawara communities, Uganda / Paula Pebsworth, Sabrina Krief, and Michael A. Huffman -- Geophagy in chimpanzees (Pan troglodytes schweinfurthii) of the Budongo Forest Reserve, Uganda : a multidisciplinary study / Mnason Tweheyo ... [et al.] -- Nutritional aspects of the diet of wild gorillas : how do Bwindi gorillas compare? / Jessica M. Rothman ... [et al.] -- The parasites of the gorillas in Bwindi Impenetrable National Park, Uganda / Jessica M. Rothman ... [et al.] -- Preliminary GIS analysis of range use by sympatric mountain gorillas and chimpanzees in Bwindi Impenetrable National Park, Uganda / J. Bosco Nkurunungi and Craig B. Stanford -- Comparison of sex differences in gregariousness in fission-fusion species : reducing bias by standardizing for party size / Melissa Emery Thompson and Richard W. Wrangham -- Urinary estrone conjugates and reproductive parameters in Kibale (Kanyawara) and Budongo (Sonso) chimpanzees / Melissa Emery Thompson, Richard W. Wrangham, and Vernon Reynolds -- Frequent copulations by females and high promiscuity in chimpanzees in the Kalinzu Forest, Uganda / Chie Hashimoto and Takeshi Furuichi -- Effects of injury on the locomotion of free-living chimpanzees in the Budongo Forest Reserve, Uganda / Julie Munn -- Effect of snare injuries on the fig-feeding behavior of chimpanzees of the Budongo Forest, Uganda : behavioral adaptations and long-term implications / Emma J. Stokes and Richard W. Byrne -- Deciphering junglespeak : an update on chimpanzee vocalizations, referential communication, and their relationship to language / Hugh Notman -- Instrumental leaf use by chimpanzees of the Budongo Forest (Sonso community) / Duane Quiatt -- A survey of prosimians in the national parks and forest reserves of Uganda / Lesley Ambrose -- The diets, preferences, and overlap of the primate community in the Budongo Forest Reserve, Uganda : effects of logging on primate diets / Andrew J. Plumptre -- Behavioral patterns of colobus in logged and unlogged forests : the conservation value of harvested forests / Colin A. Chapman, Michael D. Wasserman, and Thomas R. Gillespie -- Threats to, and protection of, the chimpanzees of the Budongo Forest Reserve / Vernon Reynolds -- Gorillas living on the edge : literally and figuratively / Michele L. Goldsmith, Joel Glick, and Evarist Ngabirano -- Local ecological perceptions of chimpanzees and forest resources : a case study near Budongo Forest, Uganda / Cristy Watkins.
  • 2011 ClinicalKey
    A Primer in Cartilage Repair and Joint Preservation of the Knee presents the full range of treatment options for a changing, increasingly younger patient population. Dr. Thomas Minas demonstrates each technique-from non-surgical to mini-incision total knee arthroplasty to the recent developments in tissue biologics-through a step-by-step approach. This highly visual, multimedia reference guides you in choosing the best treatment course for each patient. Get only the information you need through a technique-focused approach and the consistent style of a single author, Dr. Thomas Minas-a leading specialist in cartilage repair. Clearly see the nuances and important points of each technique with surgical photographs and artists' renderings of key situations in the operating room. Select the best treatment course for each patient through extensive coverage of options from non-surgical to mini-incision total knee arthroplasty.
  • Primer of arthroscopy 2010
    Overview of arthroscopy / Mark D. Miller -- Knee arthroscopy / Mark D. Miller and Jennifer A. Hart -- Hip arthroscopy / Sanaz Hariri and Marc R. Safran -- Ankle arthroscopy / Zackary D. Vaughn, Kenneth J. Hunt, and Marc R. Safran -- Shoulder arthroscopy / Melissa D. Willenborg, Mark D. Miller and Marc R. Safran -- Elbow arthroscopy / Sara D. Rynders and A. Bobby Chhabra -- Wrist arthroscopy / Sara D. Rynders and A. Bobby Chhabra.
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    Biostatistics and clinical practice -- How to summarize data -- How to test for differences between groups -- The special case of two groups the t test -- How to analyze rates and proportions -- What does "not significant" really mean? -- Confidence intervals -- How to test for trends -- Experiments when each subject receives more than one treatment -- Alternatives to analysis of variance and the t test based on ranks -- How to analyze survival data -- What do the data really show?
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  • "The purple book," gives you a comprehensive, up-to-date look at diagnostic imaging in an easy-to-read, bulleted format. Drs. Ralph Weissleder, Jack Wittenberg, Mukesh Harisinghani, and John W. Chen combine detailed illustrations and images with guidance on the latest applications of PET, CTA, and MRA into a portable resource for convenient reference wherever you go. Master the latest technologies, including hybrid PET, CTA, and MRA, through updated and expanded coverage of imaging modalities and their applications.
  • Primer of Geriatric Urology provides a review of the demographics of our aging urologic population and their unique needs. Chapters review alterations that must be considered in the initial evaluation of the aging patient, and follow with practical suggestions for development of the management plan, whether by counseling, medication, invasive procedure or foregoing procedures. Complications, especially likely in the elderly, are also discussed. The volume also provides a review of the use of necessary adjunctive services such as home care or hospice in the context of Medicare in the USA. An important chapter provides hints on urology practice in a nursing home. The volume concludes with analysis of specific geriatric entities seen in urology practice. Primer of Geriatric Urology will be of great value to urologists, residents, fellows and allied health professionals including physician's assistants and nurse practitioners who treat urologic patients. Additionally, this book will also be of interest to primary care providers who treat elderly patients with urologic problems.
  • Immunology for the Non-immunologist -- Neurology for the Non-neurologist -- Neuroimmunology for the Non-neuroimmunologist -- The Prototypic Neuroimmunological CNS Disease: Multiple Sclerosis, a Precis -- Multiple Sclerosis: Diagnosis -- Multiple Sclerosis Mimics -- Multiple Sclerosis Therapy -- Experimental Models of MS -- Guillain-Barré Syndrome (GBS) and Other Immune-Mediated Neuropathies -- Neuromuscular Neuroimmunological Diseases: Myasthenia Gravis -- The Prototypic Neuroimmunological Muscle Disease: Dermatomyositis -- A Introduction to Neurological Infections: Neuro-infectious Disease as Part of Neuroimmunology -- Neurological Manifestations of Systemic Chronic Inflammatory Disease -- The Neuroimmunology of Cancer: Paraneoplastic Syndromes and Primary CNS Lymphoma -- Neuroimmunology of Degenerative Diseases and Stroke -- Important Rare Neuroimmunological Diseases -- Neuroimmunological Molecules and Translational Medicine -- Neuroimmunological Diagnostic Tests -- Therapy in Neuroimmunological Disease.
  • Ways we see, learn, and practice medicine today : paradigms of what we are doing -- How physicians and other health professionals really (or should) think -- Reasoning in step-by-step clinical work and care : risk, diagnosis, treatment, prognosis -- Clinical and community medicine decision making -- How physicians communicate with themselves, their patients, and others : clinical communication and its vehicles -- Conclusions (with a short recapitulation) : welcome to the world of reasoned and evidence-based medicine.
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  • Primer on the Metabolic Bone Diseases and Disorders of Mineral Metabolism, 8th Edition is the comprehensive revision of the field-leading reference on bone and mineral health. The eighth edition has been fully revised by the leading researchers and clinicians in the field to provide concise coverage of the widest possible spectrum of metabolic bone diseases and disorders of mineral metabolism. Chapters look to explain basic biological factors of healthy development and disease states and make it easily translatable to clinical interventions.
  • Public health and arthritis : a growing imperative / Patience H. White and Rowland W. Chang -- Evaluation of the patient -- Musculoskeletal signs and symptoms -- Molecular and cellular basis of immunity and immunological diseases / Kevin Elias, Richard Siegel, and John J. O'Shea -- Genetics and disease / James Kelley and Robert P. Kimberly -- Rheumatoid arthritis -- Juvenile idiopathic arthritis -- Psoriatic arthritis -- Ankylosing spondylitis -- Reactive and enteropathic arthrits / Robert D. Inman -- Osteoarthritis -- Gout -- Calcium pyrophosphate dihydrate, hydroxyapatite, and miscellaneous crystals / Geraldine McCarthy -- Infectious disorders -- Systemic lupus erythematosus -- Antiphospholipid syndrome / Michelle Petri -- Systemic sclerosis -- Idiopathic inflammatory myopathies -- Metabolic myopathies / Alan N. Baer -- Sjögren's syndrome / Troy Daniels -- Vasculitides -- Relapsing polychondritis / Harvinder S. Luthra -- Adult-onset Still's disease / John M. Esdaile -- Periodic syndromes / John G. Ryan and Daniel L. Kastner -- Less common arthropathies -- Complex regional pain syndrome / Geoffrey Littlejohn -- Sarcoidosis / Edward S. Chen -- Storage and deposition diseases / Duncan A. Gordon -- The amloidoses / Pasha Sarraf and Jonathan Kay -- Neoplasms of the joint / Andrew J. Cooper, James D. Reeves, and Sean P. Scully -- Heritable disorders of connective tissue / Reed Edwin Pyeritz -- Bone and joint dysplasias / William A. Horton -- Osteonecrosis / Thorsten M. Seyler, David Marker, and Michael A. Mont -- Paget's disease of bone / Roy D. Altman -- Osteoporosis -- Rehabilitation of patients with rheumatic diseases / Thomas D. Beardmore -- Psychosocial factors in arthritis / Alex Zautra and Denise Kruszewski -- Self-management strategies / Teresa J. Brady -- Pain management / John B. Winfield -- Therapeutic injections of joints and soft tissues / Juan J. Canoso -- Nonsteroidal anti-inflammatory drugs / Leslie J. Crofford -- Glucocorticoids / Frank Buttgereit and Gerd-Rüdiger Burmester -- Operative treatment of arthritis / Joseph A. Buckwalter and W. Timothy Ballard -- Complementary and alternative therapies / Erin L. Arnold and William J. Arnold -- Criteria for the classification and diagnosis of the rheumatic diseases -- Guidelines for the management of rheumatic diseases -- Supplement and vitamin and mineral guide.
  • Written in the same conversational style as the first edition, Primer to The Immune Response, 2nd edition is a fully updated resource for college and university students in life sciences, medicine and other health professions who need a concise but comprehensive introduction to immunology. The authors bring clarity and readability to their audience, offering a complete survey of the most fundamental concepts in basic and clinical immunology while conveying the subject's fascinating appeal. The figures are now in full color, complemented by full color plates throughout the book. The text is further enhanced by the inclusion of numerous tables, special topic boxes and brief notes that provide addiitonal insights. At the end of each chapter, a self-test quiz allows students to monitor their mastery of major concepts, while a set of conceptual questions prompts them to extrapolate further and extend their critical thinking. Contains research passages that feature current experimental work reported in Cell Press articles. These articles also form the basis of case studies that are found in the associated online study guide and are designed to reinforce clinical connections.
  • pt. 1. Past, present and future of primo vascular system research -- pt. 2. Primo vascular system in various organs -- pt. 3. Primo microcell (sanAI) and stem cells -- pt. 4. Cancer -- pt. 5. Imaging, oxygen, physiology and others -- pt. 6. Acupuncture.
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    Galen of Pergamum (A.D. 129 - ca. 216) began his remarkable career tending to wounded gladiators in provincial Asia Minor. Later in life he achieved great distinction as one of a small circle of court physicians to the family of Emperor Marcus Aurelius, at the very heart of Roman society. Susan Mattern's 'The Prince of Medicine' offers the first authoritative biography in English of this brilliant, audacious, and profoundly influential figure.
  • Bernhard Gleich introduces Magnetic Particle Imaging (MPI) including all aspects that are necessary for a complete understanding. MPI is a new imaging modality invented by Bernhard Gleich and Jrgen Weizenecker. The method is capable of imaging the distribution of superparamagnetic iron oxide particles (SPIOs) with high sensitivity, high spatial resolution, and high imaging speed. The author summarizes the results of a number of original papers and countless innovations he has elaborated in the young discipline of magnetic particle imaging.
  • pt. 1. Preoperative evaluation -- pt. 2. Thoracic anatomy, physiology, and pharmacology -- pt. 3. Diagnostic and therapeutic procedures of the trachea and airways -- pt. 4. Diagnostic and therapeutic procedures of the mediastinum -- pt. 5. Anesthetic management for intra-thoracic surgery -- pt. 6. Specific patient considerations -- pt. 7. Complex thoracic surgical procedures -- pt. 8. Anesthetic management of uncommon pulmonary procedures -- pt. 9. Anesthesia for surgical procedures for end-stage lung diseases -- pt. 10. Anesthesia for pediatric thoracic surgical procedures -- pt. 11. Trauma -- pt. 12. Post-operative management.
  • Infections in patients with cancer : overview / Amar Safdar, Gerald Bodey, and Donald Armstrong -- Infections in hematopoietic stem cell transplant recipients / Georg Maschmeyer and Per Ljungman -- Infections in patients with hematologic malignancies / Genovefa Papanicolaou and Jayesh Mehta -- Infections in solid tumor patients / Alison G. Freifeld -- Infections in patients with hematologic malignancies treated with monoclonal antineoplastic therapy / André Goy and Susan O'Brien -- Postsurgery infections in cancer patients / Emilio Bouza ... [et. al] -- Management of infections in critically ill cancer patients / Henry Masur -- Management of the neutropenic patient with fever / Kenneth V. I. Rolston and Gerald P. Bodey -- Controversies in empiric therapy of febrile neutropenia / John R. Wingard -- Catheter-related infections in cancer patients / Iba Al Wohoush, Anne-Marie Chaftari, and Issam Raad -- Intravascular device-related infections : catheter salvage strategies and prevention of device-related infection / Nasia Safdar and Dennis G. Maki -- Pneumonia in the cancer patient / Scott E. Evans and Amar Safdar -- Noninfectious lung infiltrates that may be confused with pneumonia in the cancer patient / Rana Kaplan ... [et. al] -- Mucosal barrier injury and infections / Nicole M. A. Blijlevens and J. Peter Donnelly -- Bacterial colonization and host immunity / Coralia N. Mihu, Karen J. Vigil, and Javier A. Adachi -- Neutropenic enterocolitis and clostridium difficile infections / Amar Safdar ... [et. al] -- Management of reactivation of hepatitis B and hepatitis C during antineoplastic therapy / Marta Davila and Harrys A. Torres -- Management of genitourinary tract infections / Amar Safdar and Maurie Markman -- Central nervous system infections in cancer patients / Victor Mulanovich and Amar Safdar -- Endocarditis in oncology patients / Sara E. Cosgrove and Aruna Subramanian -- Skin disorders difficult to distinguish from infections / Sharone Hymes, Susan Chon, and Ana Ciurea -- Overview of invasive fungal disease in oncology patients / Amar Safdar -- Diagnosis of invasive fungal disease / Dionissios Neofytos and Kieren Marr -- Invasive candidiasis in management of infections in cancer patients / Matteo Bassetti ... [et. al] -- Management of aspergillosis, zygomycosis, and other clinically relevant mold infections / Konstantinos Leventakos and Dimitrios P. Kontoyiannis -- Cryptococcal disease and endemic mycosis / Johan A. Maertens and Hélène Schoemans -- Current controversies in the treatment of fungal infections / Christopher D. Pfeiffer, John R. Perfect, and Barbra D. Alexander -- Fungal drug resistance and pharmacologic considerations of dosing newer antifungal therapies / Russell E. Lewis and David S. Perlin -- Immunotherapy for difficult-to-treat invasive fungal diseases / Brahm H. Segal, Amar Safdar, and David A. Stevens -- Cytomegalovirus in patients with cancer / Morgan Hakki, Per Ljungman, and Michael Boeckh -- Epstein-Barr virus, varicella zoster virus, and human herpes viruses-6 and -8 / Mini Kamboj and David M. Weinstock -- Respiratory viruses / Roy F. Chemaly, Dhanesh B. Rathod, and Robert Couch -- BK, JC and parvovirus infections in patients with hematologic malignancies / Véronique Erard and Michael Boeckh -- Antiviral resistance and implications for prophylaxis / Robin K. Avery -- Management of gram-positive bacterial disease : staphylococcus aureus, streptococcal, pneumococcal, and enterococcal infections / Samuel Shelburne and Daniel M. Musher -- Infections caused by aerobic and anaerobic gram-negative bacilli / Kenneth V. I. Rolston, David E.Greenberg, and Amar Safdar -- Listeriosis and nocardiosis / Heather E. Clauss and Bennett Lorber -- Antibacterial distribution and drug-drug interactions in cancer patients / Ursula Theuretzbacher and Markus Zeitlinger -- Mycobacterium tuberculosis infection / Michael Glickman -- Nontuberculous mycobacterial infections / Amar Safdar -- Parasitic infections in cancer patients : toxoplasmosis, strongyloidiasis and other parasites / Brian G. Blackburn and José G. Montoya -- Zoonoses in cancer patients / Donald Armstrong -- Antibiotic stewardship : considerations for a cancer Center / Coralia N. Mihu, Alla Paskovaty, and Susan K. Seo -- Controversies in antimicrobial stewardship / Graeme N. Forrest -- Prevention of antimicrobial resistance : current and future strategies / Cesar A. Arias and Adolf W. Karchmer -- Antibacterial, antifungal, and antiviral prophylaxis / Marcio Nucci and John R. Wingard -- Controversies in antimicrobial prophylaxis / Ben de Pauw and Marta Stanzani -- Infection prevention : protected environment and infection control / J. Peter Donnelly -- Prevention of tropical and parasitic infections : the immunocompromised traveler / Francesca F. Norman and Rogelio López-Vélez -- Prophylactic vaccination of cancer patients and hematopoietic stem cell transplant recipients / William Decker and Amar Safdar.
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  • This expanded third edition provides an introduction to the conduct of clinical research as well as more comprehensive and expansive content about the infrastructure necessary for a successful clinical research organization or enterprise. With authors who are experts in clinical research in both the public and private sectors, this publication provides essential information to clinical investigators who wish to develop and conduct well designed patient-based research protocols that comply with rigorous study design, ethical, and regulatory requirements.
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    v. 3. Treatment.
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    Choice of the hemodialysis membrane / L.L. Ford, R.A. Ward, A.K. Cheung -- Reuse of hemodialysis membranes in chronic dialysis therapy / P.D. Light -- Dialysate composition in hemodialysis and peritoneal dialysis / B.F. Palmer -- Hemodialysis vascular access / C.A. Green, S.J. Schwab -- Anticoagulation strategies during hemodialysis procedures / W.J. Dahms -- Approach to hemodialysis kinetic modeling / T.A. Depner -- Choosing the best dialysis option in the patient with end-stage kidney disease / R. Cunningham -- Hemodialysis adequacy and the timing of dialysis initation / A.S. OConnor, J.B. Wish -- High-flux and high-efficiency procedures / E.M. Simmons, B.B. Weathersby, S.D. Clyne, F.V.Arndt, T.A.Golper -- Long and daily hemodialysis / A. Pierratos -- Prescribing drugs for dialysis patients / A.J. Olyaei, I. Wahba, W.M. Bennett -- Continuous dialysis therapeutic techniques / N. Khosla, R.L. Mehta -- Choosing the best dialysis option in patients with acute renal failure and in the intensive care unit / A.E. Briglia -- Adequacy of peritoneal dialysis / J.M. Burkart -- Causes, diagnosis, and treatment of peritoneal membrane failure / S. Bansal, I. Teitelbaum -- Hypertension in dialysis patients / V.M. Campese, J. Vidhun, J. Park -- Left ventricular dysfunction and valvular heart disease in dialysis patients / S.W. Murphy, P.S. Parfrey -- Coronary artery diease in end-stage renal disease patients / W.Y. Qunibi, W.L.Henrich, L.D.Hillis -- Hemodynamic stability and autonomic dysfunction in end-stage renal disease / B.F. Palmer, W.L. Henrich -- Oxidant stress in end-stage renal disease / R.K. Wali -- Low-grade persistent inflammation and immune dysfunction in uremia / J.J. Carrero, C.M. Avesani, M.I. Yilmaz, B. Lindholm, P. Stenvinkel -- Hepatitis and human immunodeficiency virus infections in end-stage renal disease patients / R.E. Berggren -- Endocrine disease in dialysis patients / E.F.O. Kern, R. Tyler Miller -- Gastrointestinal complications in end-stage renal disease / G.T. Fantry, D.S. Hanes -- Renal osteodystrophy / W.Y. Qunibi -- Acid- base considerations in end-stage renal diease / F.J. Gennari -- Dyslipidemia in dialysis patients / R. Toto -- Malnutrition and intradialytic parenteral nutrition in patients with end-stage renal disease / J.D.Kopple, K.Kalantar-Zadeh -- Disorders of hemostasis in dialysis patients / G. Remuzzio, M.Galbusera, P. Boccardo -- Treatment of anemia in patients with end-stage renal disease / A. Besarab, J. Yee -- Neurologic complications associated with dialysis and chronic renal insufficiency / I.I Ali, N.A. Pirzada -- Geriatric dialysis patient / L.A. Stevens, D.E. Weiner, W.W. Brown -- Dialytic therapy for renal failure in pandemic diabetes and nephropathy / A.J. Joseph, E.A. Friedman -- Quality of life rehabilitation in dialysis patients / D.J. Salzberg -- Extracorporeal treatment of poisoning and drug overdose / W.Y. Qunibi -- Chronic dialysis in children / B.A. Warady, K. Jabs, S.L. Goldstein -- Acute dialysis in children / S.R. Mendley -- Infections in patients on peritoneal dialysis / G.R. Thompson, J.E. Patterson -- Preparing dialysis patients for renal transplantation / M.R. Weir, C.B. Cangro, D.K. Klassen -- Current outcomes for dialysis patients and improving quality of care for dialysis patients / J.C. Fink.
  • Gastrointestinal cancer: epidemioloy -- Gastrointestinal cancer: pathology and molecular pathology -- Gastrointestinal cancer: cancer genetics -- Gastrointestinal cancer: screening and surveillance -- Gastrointestinal cancer: surgical oncology -- Gastrointestional cancer management: biological aspects of radiation therapy -- Gastrointestinal cancer: medical oncology -- Gastrointestinal cancer: nutritional support -- Imaging of gastrointestinal malignancies -- Endoscopic diagnosis, staging, and management of gastrointestinal cancers -- An overview of outcomes research in gastrointestinal cancer -- Integrative oncology: complementary therapies in gastrointestinal cancer care -- Pain and symptom control -- Esophageal cancer: epidemiology, screening, and prevention -- The molecular genetics of esophageal cancer -- Esophageal cancer: pathology -- Esophageal cancer: anatomy and staging -- Esophageal cancer: clinical management -- Gastric cancer: epidemiology, screening, surveillance, and prevention -- Gastric cancer: molecular biology and genetics -- Gastric cancer: pathology -- Gastric cancer: staging systems and techniques -- Gastric cancer: clinical management -- Pancreas cancer: epidemiology and risk factors -- Pancreatic cancer: molecular biology and genetics -- Pancreas cancer: anatomy, staging systems, and techniques -- Pathology of pancreatic cancer -- Pancreas cancer: clinical management -- Hepatocellular carcinoma: epidemiology, screening and prevention -- Hepatocellular carcinoma: molecular biology and genetics -- Hepatocellular cancer: pathology -- Hepatocellular cancer: anatomy and staging -- Hepatocellular cancer: clinical management -- Cancer of the gallbladder and biliary tree: epidemiology -- Pathology of biliary tract cancer -- Cancers of the biliary tree: anatomy and staging -- Cancers of the biliary tree: clinical management -- Environmental and lifestyle issues in colorectal cancer -- Colorectal cancer: screening and surveillance -- Colorectal cancer: molecular biology and genetics -- Colorectal cancer: pathology -- Colorectal cancer: anatomy and staging -- Colon cancer: management of locoregional disease -- Rectal cancer: management of locoreginal disease -- Systemic therapy for metastatic colorectal cancer -- Colorectal cancer: surgery and local ablation of liver metasteses -- Anal canal cancer -- Neuroendocrine tumors of the gastrointestinal tract -- Lymphomas of the gastrointestinal tract -- Gastrointestinal stromal tumors -- Small bowel cancers -- Cancer of unknown primary site -- Malignant peritoneal mesothelioma.
  • The goal of the book is provide trainees, junior and senior clinicians, and other professionals with a comprehensive resource that they can use to improve care processes and performance in the hospitals that serve their communities. Includes case studies.
  • General Topics -- History of the Rigid Bronchoscope / Heinrich D. Becker -- General Principles of Endoscopic Imaging / Harald W. Dremel -- The Bronchoscope: What is Available, Determining Selection, and How to Properly Care for the Instrument / Robert Garland -- Bronchoscopy Unit Design for Advanced Procedures / Robert Garland -- Quality Control Mechanism for Endoscopic Procedures / Michael J. Simoff -- Moderate and Deep Sedation Techniques / John Pawlowski -- Physiology of Fixed Airway Obstruction / Ross K. Morgan -- Airway Imaging / Claus P. Heussel -- Airway Anatomy / Arthur Sung -- Bronchoscopy Education / Henri G. Colt -- Simulation for Endoscopy Training / Momen M. Wahidi -- Principles of Cancer Staging / Paul Baas -- Bronchoscopy, Section 1: Diagnostic Procedures -- Laryngoscopy / Ulrich Goessler -- Assessment of Vocal Cord Function and Voice Disorders / Phillip Song -- Conventional Biopsy Techniques / Stefano Gasparini -- Bronchoalveolar Lavage / Franz Stanzel -- Radial Endobronchial Ultrasound / Felix J. F. Herth -- Linear Endobronchial Ultrasound / Kazuhiro Yasufuku -- Esophageal Ultrasound / Jouke T. Annema -- EBUS Guidance for Peripheral Biopsies / Ralf Eberhardt -- Autofluorescence Bronchoscopy and Narrow Band Imaging / Pyng Lee -- Confocal Imaging / Devanand Anantham -- Optical Coherence Tomography / Ross G. Michel -- Image-Guided Bronchoscopy / Rabih Bechara -- Bronchoscopy, Section 2: Therapeutic Interventions -- Malignant Central Airway Obstruction / Gaëtane Michaud -- Management Principles of Nonmalignant Airway Obstruction / Devanand Anantham -- Rigid Bronchoscopy / Jed A. Gorden -- Metallic Stenting / Mark Slade -- Endobronchial Silicone Stents for Airway Management / Hervé Dutau -- Y-Stenting Techniques / Daniela Gompelmann -- Montgomery T-Tubes / Carla R. Lamb -- Electrosurgery / Tom Gani Sutedja -- Cryotherapy and Cryodebridement / Ramez Sunna -- Microdement / William Lunn -- Use of Medical Lasers for Airway Disease / Jeffrey B. Hoag -- Brachytherapy / Maher Tabba -- Photodynamic Therapy / Chakravarthy Reddy -- Balloon Dilation Techniques / Kevin L. Kovitz -- Radiation Therapy and Techniques for Fiducial Placement / Martin L. Mayse -- Management of Subglottic Stenosis and Subglottic Stenosis in Systemic Disease / António Bugalho -- Treatment of Airway-Esophageal Fistulas / Lutz Freitag -- Endoscopic Management of Bronchopleural Fistulas / David M. Berkowitz -- Endoscopic Lung Abscess Drainage / Felix J. F. Herth -- Management of Massive Hemoptysis / Andrew R. Haas -- Management of Posttransplant Disorders / Michael S. Machuzak -- Foreign Body Removal / Mark E. Lund -- Resection and Reconstruction of Central Airways / Hendrik C. Dienemann -- Techniques for Laryngotracheal Reconstruction / Ramon Franco Jr. -- Bronchoscopic Lung Volume Reduction / Armin Ernst -- Surgical Lung Volume Reduction / Walter Weder -- Endoscopic Asthma Treatment / Gerard P. Cox MB, BCh, FRCP(C), FRCP (I) -- Image-Guided Ablation Treatment for Lung Cancer Patients / Damian E. Dupuy -- - Thoracoscopy -- Pleural Anatomy and Fluid Analysis / Y. C. Gary Lee -- Pleural Imaging / Fergus Gleeson -- Pleural Manometry / David Feller-Kopman -- Thoracentesis / Sara R. Greenhill -- Chest Tube Placement / Michael Klopp -- Small-Bore Drains and Indwelling Catheters / Saleh Alazemi -- Medical Thoracoscopy/Pleuroscopy / Robert Loddenkemper -- Pleurodesis / Julius Janssen -- Advanced Medical Thoracoscopy-Pleuroscopy Procedures / Marios E. Froudarakis -- VATS Surgical Techniques / Hans Hoffmann -- Management Principles of Empyema / Anne V. Gonzalez -- Management of Malignant Pleural Effusions / Andrew G. Villanueva -- Approach to Unclear Exudates / Gaëtane Michaud -- Airway Access Techniques -- Percutaneous Tracheotomy / Lonny Yarmus -- Cricothyroidotomy / Joshua B. Silverman -- Transtracheal Oxygen Catheter Placement and Management / Kent L. Christopher -- Other Endoscopic and Novel Techniques -- Natural Orifice Transluminal Endoscopic Surgery (NOTES) / Felix J. F. Herth -- Percutaneous Endoscopic Gastrostomy (PEG) Tube Placement / Maren Schuhmann -- Whole-Lung Lavage / Chakravarthy Reddy.
  • Lacrimal Disorders and Surgery: Historical Perspective -- Embryology of the Lacrimal Drainage System -- Anatomy, Physiology and Immunology of Lacrimal System -- Paradigm Shifts in Lacrimal Anatomy -- The Sino-nasal Anatomy: Endoscopic Lacrimal and Orbital Perspectives -- Evaluation of Epiphora -- Set up for Nasal Endoscopy and Endoscopic Surgery -- Nasal Endoscopic Evaluation -- Dacryoendoscopic Examination of the Lacrimal System -- Imaging Modalities for Lacrimal Disorders -- Disorders of the Upper Lacrimal System -- Congenital Nasolacrimal Duct Obstructions Primary and Secondary Acquired Lacrimal Duct Obstructions (PANDO and SALDO) -- Functional Obstructions of the Lacrimal System -- Infections of the Lacrimal Drainage System -- Lacrimal Trauma and its Management -- Primary External Dacryocystorhinostomy -- Endoscopic Guided Single Self-linking of Stents -- Aesthetic External Dacryocystorhinostomy: The Subciliary Approach -- Aesthetic External Dacryocystorhinostomy: The Transconjunctival Approach -- Primary Endoscopic Dacryocystorhinostomy -- Ultrasonic Endoscopic Dacryocystorhinostomy -- Non-endoscopic Endonasal Dacryocystorhinostomy -- Primary Endocanalicular Laser Dacryocystorhinostomy -- 5mm and 9mm Balloon Assisted Dacryocystorhinostomy -- Revising a Failed Dacryocystorhinostomy Conjunctivodacryocystorhinostomy: Indications, Techniques and Complications -- Adjunctive Endonasal Procedures with Dacryocystorhinostomy -- Evaluation of a Dacryocystorhinostomy Ostium and DOS Scoring -- Intubation in Lacrimal Surgery: Devices and Techniques -- Pediatric and Adult Balloon Dacryoplasty -- Dacryoendoscopic guided canalicular and nasolacrimal duct recanalization -- Tumors of the Lacrimal Drainage System -- Dacryocystectomy: Indications and Techniques -- Debates in Dacryology: The Ostium Dilemma! -- Selva -- Debates in Dacryology: The Mitomycin C Dilemma -- Debates in Dacryology: The Intubation Dilemma! -- The Great Debate: External versus Endonasal Dacryocystorhinostomy -- Quality of Life in Lacrimal Disorders and Patient Satisfaction following Management -- Future Directions in Lacrimal Disorders and their Management. Lacrimal disorders are one of the very common conditions encountered not only by the oculoplastic surgeons but also by the general ophthalmologists in their daily practice. Written by global experts in the field of dacyrology, this book is a comprehensive, updated practical guide on evaluation and management of patients with lacrimal diseases. This up-to-date reference work covers all aspects of the field including the basic anatomy and underlying pathology, evaluation of a patient, and all surgical procedures currently used in managing various disorders in an organized fashion. Surgical modalities including the endoscopic approaches are thoroughly and succinctly reviewed with ample illustrations for better understanding. Since familiarity with a surgical technique is incomplete without the knowledge of risk factors and red flags, an emphasis on dealing with surgical complications and failure has received priority in this treatise. Controversial topics and treatment dilemmas have been discussed in detail with the objective of reviewing the present consensus among the experts.
  • Expand your skills in the rapidly growing field of laser dentistry! The new second edition of Principles and Practice of Laser Dentistry contains everything you need to know about the latest laser procedures across all areas of dentistry. With vivid clinical photos and easy-to-follow writing, Dr. Robert A. Convissar and his team of dental experts walk you through the most common uses of lasers in areas like: periodontics, periodontal surgery, oral pathology, implantology, fixed and removable prosthetics, cosmetic procedures, endodontics, operative dentistry, pediatrics, orthodontics, and oral and maxillofacial surgery. The book also covers topics such as the history of lasers in dentistry, laser research, the latest laser equipment, and how to go about incorporating lasers into your practice, so that you are fully equipped to use lasers successfully in your treatments.
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  • Pt. I. General information -- Epidemiology and etiology of breast cancer -- Staging of breast cancer -- Molecular classification -- Prognostic and predictive factors -- Mechanisms of resistance to radiation -- Interaction of chemotherapy, radiotherapy, and timing -- Interactions of radiotherapy with hormonotherapy -- pt. II. Therapeutic results of radiotherapy in breast cancer -- Ductal carcinoma in situ -- Early stage breast cancer -- Locally advanced breast cancer -- Metastatic breast cancer -- pt. III. Radiotherapy atlas in breast cancer -- The organs at risk and radiation tolerance doses -- Chest wall and regional lymphatics -- Breast and tumor bed -- pt. IV. Modern radiotherapy techniques in breast cancer -- Simulation and patient fixation methods -- Three-dimensional planning techniques -- Inverse planning, intensity modulated radiation therapy, and image-guided radiation therapy -- Forward planning intensity modulated radiation therapy techniques -- Boost techniques -- Quality assurance -- Partial breast irradiation -- Hypofractionation -- Application of tomotherapy in breast cancer patients -- pt. V. Radiotherapy complications in breast cancer -- Radiotherapy complications.
  • 2011 ClinicalKey
    Principles and Practice of Movement Disorders provides the complete, expert guidance you need to diagnose and manage these challenging conditions. Drs. Stanley Fahn, Joseph Jankovic and Mark Hallett explore all facets of these disorders, including the latest rating scales for clinical research, neurochemistry, clinical pharmacology, genetics, clinical trials, and experimental therapeutics. This edition features many new full-color images, additional coverage of pediatric disorders, updated Parkinson information, and many other valuable updates. An accompanying Expert Consult website makes the content fully searchable and contains several hundred video clips that illustrate the manifestations of all the movement disorders in the book along with their differential diagnoses. Get just the information you need for a clinical approach to diagnosis and management, with minimal emphasis on basic science. Find the answers you need quickly and easily thanks to a reader-friendly full-color format, with plentiful diagrams, photographs, and tables.
  • This book provides the reader with an understanding of human nutritional and metabolic physiology and how it goes wrong in illness. Divided into three major sections, the volume instructs the reader on how and when to use nutritional support, and includes a summary of the published outcome studies on the application of nutritional support to the management of common illnesses. In this way, the book supplies the reader with all the known information on how to make the best judgment of when, what and how to feed sick patients. Authored by a renowned expert in the field, The Principles and Practice of Nutritional Support is a valuable resource for gastroenterologists, surgeons, critical care physicians, endocrinologists, and all those involved with patient-care, both in hospital, in rehabilitation, or at home.
  • Difficult pain syndromes: neuropathic pain, bone pain, and visceral pain -- Opioid pharmacotherapy -- Nonpharmacologic management of pain -- Interventional approaches to pain -- Pathology of bone metastases-implications for treatment -- Pathophysiology of chemotherapy-induced peripheral neuropathy -- Cancer-related fatigue -- Fever and sweats -- Hot flashes -- Anorexia/weight loss -- Dysphagia/speech rehabilitation in palliative care -- Chemotherapy-related nausea and vomiting and treatment-related nausea and vomiting -- Assessment of management of chronic nausea and vomiting -- Diarrhea, malabsorption, and constipation -- Bowel obstruction -- Diagnosis and management of effusions -- Hiccups and other gastrointestinal symptoms -- Biology of treatment-induced mucositis -- Oral manifestations and complications of cancer therapy -- Approach to liver metastases in palliative oncology -- Palliative endoscope procedures -- Palliative interventional radiologic procedures -- Pruritus -- Treatment of tumor-related skin disorders -- Dermatologic adverse events during treatment -- Management of pressure ulcers and fungating wounds -- Lymphedema -- Principles of fistula and stoma management -- Dyspnea in the cancer patient -- Hemoptysis, airway obstruction, bronchospasm, cough, and pulmonary complications/symptoms of cancer and its treatment -- Prevention, assessment, and management of treatment-induced cardiac disease in cancer patients -- Management of hypercoagulable states and coagulopathy -- Urologic issues in palliative care -- Impact of hepatic and renal dysfunction on pharmacology of palliative care drugs -- Hypercalcemia -- Metabolic disorders in the cancer patient -- Infectious complications/management -- Management of intracranial metastases -- Management of spinal cord and cauda equina compression -- Recognizing and managing delirium -- Treating depression at the end of life -- Anxiety -- Cognitive decline following cancer treatment -- Substance-abuse issues in palliative care -- Epidemiology and prognostication in advanced cancer -- Hospice -- Cultural issues -- Communication during transitions of care -- The family meetings -- Psychosocial consequences of advanced cancer -- Disorders of sexuality and reproduction -- Caregiving in the home -- Management of symptoms in the actively dying patient -- Spirituality -- Bereavement care -- Staff stress and burnout -- Advance directives, decision making, and withholding and withdrawing treatment -- Palliative care: ethics and the law -- Hematologic support of the cancer patient -- Issues in nutrition and hydration -- Complementary, alternative, and integrative therapies in oncology -- Geriatric palliative care -- Palliative care in pediatrics -- Hematopoietic stem cell transplantation and supportive care -- Long-term survivorship: late effects -- Survivorship issues in adults -- Outcomes assessment in palliative care -- Measurement of quality of life outcomes -- Research issues: ethics and study design.
  • Pt. 1. Understanding, controlling, and preventing infectious diseases. -- Pt.2. Clinical syndromes and cardinal features of infectious diseases: approach to diagnosis and initial management. -- Pt.3. Etiologic agents of infectious diseases. -- Pt.4. Laboratory diagnosis and therapy of infectious diseases.
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  • Principles and Practice of Pediatric Sleep Medicine, 2nd Edition, written by preeminent sleep medicine experts Drs. Sheldon, Kryger, Ferber, and Gozal, is the most comprehensive source for diagnosing and managing sleep disorders in children. Newly updated and now in full color throughout, this medical reference book is internationally recognized as the definitive resource for any health practitioner who treats children, providing absolute guidance on virtually all of the sleep-associated problems encountered in pediatric patients. Organized format separates coverage into Normal and Abnormal sleep for quick access to the key information you need.Abundantly referenced chapters help you to investigate topics further. Equips you with a complete understanding of both medical and psychiatric sleep disorders.
  • Sect I. Basic considerations -- Part A. Scientific principles -- Part B. Trauma -- Part C. Oncology -- Part D. Transplantation -- Sect. II. Surgical practice -- Part A. Head and neck -- Part B. Thorax -- Part C. Abdomen and abdominal wall defects -- Part D. Intestine -- Part E. Colon -- Part F. Liver, biliary Tract, and pancreas -- Part G. Spleen -- Part H. Urinary and genital systems -- Part I. Vascular system -- Part J. Musculoskeletal system -- Part K. Skin and soft tissue -- Part L. Central nervous system / Herbert Edgar Fuchs -- Part M. Conjoined Twins / John H.T. Waldhausen - Index.
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  • Machine generated contents note: pt. ONE Background and strategies -- 1.Herbal therapeutic systems -- 2.Principles of herbal pharmacology -- 3.Principles of herbal treatment -- 4.Validating herbal therapeutics -- 5.Optimising safety -- pt. TWO Practical clinical guides -- 6.Dosage and dosage forms in herbal medicine -- 7.A systematic approach to herbal prescribing -- 8.Herbal approaches to pathological states -- Topical applications -- Fever -- Infectious diseases -- Inflammatory and autoimmune diseases -- Fatigue and debility -- Malignant diseases -- 9.Herbal approaches to system dysfunctions -- Digestive system and bowel -- Biliary system -- The liver -- Cardiovascular system -- Respiratory system -- Urinary system -- Nervous system -- Female reproductive system -- Joint diseases -- Skin diseases -- Male reproductive system -- Endocrine disorders -- pt. THREE Materia Medica -- 10.How to use the monographs -- Andrographis -- Arnica flowers -- Astragalus -- Bearberry -- Contents note continued: Berberis bark and Hydrastis root -- Bilberry fruit -- Black cohosh -- Boswellia -- Buchu -- Bugleweed and European bugleweed -- Bupleurum -- Butcher's broom -- Chamomile, German -- Chaste tree -- Chelidonium -- Devil's claw -- Dong quai -- Echinacea root -- Evening primrose oil -- Eyebright -- Fennel fruit -- Feverfew -- Ginger -- Ginkgo -- Ginseng -- Globe artichoke -- Gotu kola -- Hawthorn -- Horsechestnut seed -- Kava -- Licorice -- Meadowsweet -- Melilotus -- Myrrh -- Nettle -- Pau d'arco -- Peppermint -- Poke root -- Rehmannia -- Saw palmetto -- Siberian ginseng -- St John's wort -- St Mary's thistle -- Thyme -- Tribulus leaf -- Turmeric -- Valerian -- Willow bark -- Witchhazel -- Withania.
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  • "Fully updated for its Fifth Edition, Principles and Practice of Psychopharmacotherapy summarizes the latest data on hundreds of drug and device-based therapies and offers practical, evidence-based guidelines and treatment strategies for virtually every psychiatric disorder. Highlights of this edition include expanded coverage of pharmacogenomics, updates on treatments for elderly patients, and discussion of mechanisms of action for drugs used in sleep disorders, especially narcolepsy"--Provided by publisher.
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  • 2011 ClinicalKey
  • Principles and Practice of Stereotactic Radiosurgery (SRS), Second Edition aims to serve as the definitive reference textbook for SRS practitioners. It provides a theoretical basis for the use of therapeutic SRS including imaging techniques and radiobiology. The bulk of the textbook contains chapters that are comprehensive in scope on all diseases that are treated by SRS. Lastly, it addresses administrative and technical aspects of running an SRS unit. Each chapter provides an expansive treatment of the subject. Emphasis is placed on the technical aspects of SRS so that practitioners in this field will use it as a daily reference. Each subject is presented by historical context, then by its pathophysiology. Current treatment methods and results are addressed in depth. A liberal use of tables and figures enhance the presentation. A review of all major clinical studies and representative case presentations, where possible, are provided with imaging, treatment planning, and follow-up results. Each chapter is followed by one or two mini-chapters that provide a counter-viewpoint experience to the main chapter, which is oriented to SRS. These counter-viewpoint chapters are written by a noted expert in that field and address in greater detail the indications, results, and complications of their approach to the disease discussed in the main chapter. Principles and Practice of Stereotactic Radiosurgery, Second Edition is the only reference needed for neurosurgeons, radiation oncologists, and medical physicists at all levels of training and practice who are interested in SRS.
  • Supplying lavish color illustrations that fully detail key anatomical structures and pathology, this Third Edition encompasses the complete range of diseases encountered by colorectal surgeons in day-to-day clinical practice and spans topics related to anorectal disorders, colorectal conditions, problem-oriented approaches to colorectal disease, and laparoscopic colorectal surgery. Documenting the most recent surgical developments and instrumentation methods, this Third Edition provides updated chapters on sophisticated diagnostic and therapeutic modalities, pharmaceutical advances, and patient screening, surveillance, and follow-up care.
  • Metabolic response to injury, fluid and electrolyte balance and shock -- Transfusion of blood components and plasma products -- Nutritional support in surgical patients -- Infections and antibiotics -- Ethics, preoperative considerations, anaesthesia and analgesia -- Trauma and multiple injury -- Practical procedures and patient investigation -- Postoperative care and complications -- Day surgery -- The abdominal wall and hernia -- The acute abdomen and intestinal obstruction -- The oesophagus, stomach and duodenum -- The liver and biliary tract -- The pancreas and spleen -- The small and large intestine -- The anorectum -- Plastic and reconstructive surgery -- The breast -- Endocrine surgery -- Vasucla and endovascular surgery -- Cardiothoracic surgey -- Neurosurgery -- Transplantation surgery -- Ear, nose and throat surgery -- Orthopaedic surgery.
  • Despite the wide prevalence of urogynaecological problems, in clinical practice, there is a paucity of specialists that are skilled in the management of these conditions. The recognition of the need for a specialist to deal with these specific problems has led to the recent evolution of urogynaecology as a subspecialty. This book, Principles and Practice of Urogynaecology, aims to equip the practicing professionals - Gynaecologists, Urogynaecologists and Urologists, with up-to-date information on the principles that guide the evaluation and management of pelvic organ prolapse and other common urogynaecological problems. With an emphasis on evidence based medicine, the book aims to deliver guidance on management of common urogynaecological problems and provides information on the latest cutting-edge surgical techniques. Written by global experts in the field of urogynaecology, the book focuses initially on pelvic floor anatomy and function, moving seamlessly to the evaluation and management of clinically relevant pelvic floor problems. A detailed discussion on management of mesh related complications is a highlight.
  • Principles and Practice of Wrist Surgery, by David J. Slutsky, MD, FRCS, offers current, comprehensive guidance for addressing the challenging and quickly growing incidence of wrist injuries. Joined by a world-class team of contributors, Dr. Slutsky presents today's best treatment options and surgical techniques for a full range of scenarios ... from occupational disorders and sports injuries to age-related conditions. Inside you'll find discussions of the most current developments in minimally invasive arthroscopic and percutaneous procedures, the very latest in locked plating and internal fixation technology, the state-of-the-art in arthroplasty techniques for degenerative and inflammatory arthritis, unparalleled coverage of ulnar injuries and techniques, complications and salvage, compression neuropathies, and much more. A bonus DVD of surgical videos depicts the technical details of each procedure to further help you refine your skills. Expert Consult functionality offers convenient access to the complete contents of the book and DVD online. Provides access to the complete text online, fully searchable, along with all of the illustrations downloadable for your personal presentations, and a link to a video library of all of the DVD videos, at Features the practice-proven experience of internationally recognized experts in hand surgery, for guidance you can trust. Equips you with today's management options and techniques for a full range of wrist disorders and injuries - from trauma and soft tissue injuries ... to complications and salvage ... to pediatric conditions. Includes a brief basic science section providing just the essential new developments in anatomy and biomechanics to keep you up to date on the latest breakthroughs. Offers a clinically focused, consistent organization throughout - with each chapter addressing a specific injury or surgical technique - making reference easy. Captures intraoperative details as they appear in the OR through a full-color format along with interpretive drawings of surgical technique.
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  • Anatomy of the airway -- Evaluation of the airway -- Basic emergency airway management and cardiopulmonary resuscitation (CPR) -- Basic equipment for airway management -- The laryngeal mask airway (LMA) and other extraglottic (supraglottic) airway devices -- Advanced airway devices -- Indications and preparation of the patient for intubation -- Techniques of intubation -- The difficult airway -- Pediatric airway management -- Fiberoptically guided airway management techniques -- Surgical options in airway management -- Mechanical ventilation and respiratory care -- Extubation strategies: the extubation algorithm -- Complications of airway management.
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  • Basic biostatistics for the clinical trialist / Elizabeth G. Hill and Elizabeth Garrett-Mayer -- Fundamental concepts in clinical pharmacology / Daniel L. Gustafson and Erica L. Bradshaw-Pierce -- Bioanalycial methods in clinical drug development / Walter J. Loos, Peter de Bruijn and Alex Sparreboom -- Preclinical models for anticancer drug development / Edward A. Sausville -- Phase I clinical trials with anticancer agents / Stephen Leong ... [et al.] -- Phase II trials with anticancer agents / Hui K. Gan, J. Jack Lee and Lillian L. Siu -- Phase III clinical trials with anticancer agents / Wendy R. Parulekar and Daniel J. Sargent -- Pharmacokinetic studies in early anticancer drug development / Alex Sparreboom and Sharyn D. Baker -- Pharmacodynamic studies in early phase drug development / D. Ross Camidge, Robert C. Doebele and Antonio Jimeno -- Prediction of antitumor response / Fred R. Hirsch and Yu Shyr -- Imaging studies in anticancer drug development / David A. Mankoff -- Role of the U.S. Food and Drug Administration in cancer drug development / Ann T. Farrell, Ramzi N. Dagher and Richard Pazdur -- Early clinical trials with cytotoxic agents / M.J.A. de Jonge and Jaap Verweij -- Challenges and successes in developing effective anti-angiogenic agents / Laura Q.M. Chow and S. Gail Eckhardt -- Targeted therapeutics in cancer treatment / Colin D. Weekes and Manuel Hidalgo -- Cancer chemoprevention / Christopher H. Lieu, William N. William Jr. and Scott Lippman -- Combined modality therapy in cancer management / David Raben and Kyle Rusthoven -- Cancer vaccines / Daniel Laheru -- Optimising the development of antibodies as treatment for cancer / Craig P. Carden, Hendrik-Tobias Arkenau and Johann S. de Bono -- Oligonucleotide therapeutics / Cy A. Stein, Britta Hoehn and John Rossi -- Anticancer drug development in pediatric patients / Lia Gore and Margaret Macy -- Clinical trials in special populations / S. Percy Ivy ... [et al.] -- NCI-sponsored clinical trials / Andriana Papaconstantinou and Janet E. Dancey.
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    Part I. Moral foundations. Moral norms. Normative and nonnormative ethics ; The common morality as universal morality ; Particular moralities as nonuniversal ; Moral dilemmas ; A framework of moral norms ; Conflicting moral norms -- Moral character. The concept of moral virtue ; Virtues in professional roles ; The virtue of caring ; Five focal virtues ; Moral ideals ; Moral excellence -- Moral status. The problem of moral status ; Theories of moral status ; From theories to practical guidelines ; The moral significance of moral status ; Vulnerable populations and vulnerable individuals -- Part II. Moral principles. Respect for autonomy. The concept of autonomy and the principle of respect for autonomy ; The capacity for autonomous choice ; The meaning and justification of informed consent ; Disclosure ; Understanding ; Voluntariness -- Nonmaleficence. The concept of nonmaleficence and the principle of nonmaleficence ; Distinctions and rules governing nontreatment ; Optional treatments and obligatory treatments ; Killing and letting die ; The justification of intentionally arranged deaths ; Problems of group harm ; Protecting incompetent patients -- Beneficence. The concept of beneficence and principles of beneficence ; Obligatory beneficence and ideal beneficence ; Paternalism : conflicts between beneficence and respect for autonomy ; Balancing benefits, costs, and risks ; The value and quality of life -- Justice. The concept of justice and principles of justice ; Traditional theories of justice ; Recent theories of justice ; Fair opportunity and unfair discrimination ; Vulnerability, exploitation, and discrimination in research ; National health policy and the right to health care ; Global health policy and the right to health ; Allocating, setting priorities, and rationing -- Professional-patient relationships. Veracity ; Privacy ; Confidentiality ; Fidelity ; Clinical ethics and research ethics ; The dual roles of clinician and investigator -- Part III. Theory and method. Moral theories. Criteria for assessing moral theories ; Utilitarian theory ; Kantian theory ; Rights theory ; Virtue theory ; Convergence of theories -- Method and moral justification. Justification in ethics ; Top-down models : theory and application ; Bottom-up models : cases and analogical reasoning ; Reflective equilibrium as an integrated model ; Common-morality theory.
  • This second edition of a pioneering technical work in biomedical informatics provides a very readable treatment of the deep computational ideas at the foundation of the field. Principles of Biomedical Informatics, 2nd Edition is radically reorganized to make it especially useable as a textbook for courses that move beyond the standard introductory material. It includes exercises at the end of each chapter, ideas for student projects, and a number of new topics, such as: .tree structured data, interval trees, and time-oriented medical data and their use . On Line Application Processing (OLAP), an old database idea that is only recently coming of age and finding surprising importance in biomedical informatics a discussion of nursing knowledge and an example of encoding nursing advice in a rule-based system X-ray physics and algorithms for cross-sectional medical image reconstruction, recognizing that this area was one of the most central to the origin of biomedical computing .an introduction to Markov processes, and an outline of the elements of a hospital IT security program, focusing on fundamental ideas rather than specifics of system vulnerabilities or specific technologies. It is simultaneously a unified description of the core research concept areas of biomedical data and knowledge representation, biomedical information access, biomedical decision-making, and information and technology use in biomedical contexts, and a pre-eminent teaching reference for the growing number of healthcare and computing professionals embracing computation in health-related fields. As in the first edition, it includes many worked example programs in Common LISP, the most powerful and accessible modern language for advanced biomedical concept representation and manipulation. The text also includes humor, history, and anecdotal material to balance the mathematically and computationally intensive development in many of the topic areas. The emphasis, as in the first edition, is on ideas and methods that are likely to be of lasting value, not just the popular topics of the day. Ira Kalet is Professor Emeritus of Radiation Oncology, and of Biomedical Informatics and Medical Education, at the University of Washington. Until retiring in 2011 he was also an Adjunct Professor in Computer Science and Engineering, and Biological Structure. From 2005 to 2010 he served as IT Security Director for the University of Washington School of Medicine and its major teaching hospitals. He has been a member of the American Medical Informatics Association since 1990, and an elected Fellow of the American College of Medical Informatics since 2011. His research interests include simulation systems for design of radiation treatment for cancer, software development methodology, and artificial intelligence applications to medicine, particularly expert systems, ontologies and modeling.
  • v. 1.-- Part. I. Basic principles -- v. 2.-- Part. II. Molecular mechanisims of metabolic bone diseases -- Part. III. Pharmacological mechanisms of therapeutics -- Part. IV. Methods in bone research.
  • Part 1. Physiology of Bone Healing / Cellular and Molecular Aspects of Bone Repair / Itai A. Bab and Jona J. Sela -- Primary Mineralization / Jona J. Sela -- Healing of Bone Fracture: General Concepts / Jona J. Sela and Itai A. Bab -- Part 2. Systemic Factors in Bone Healing / Anabolic Agents in Bone Repair / Itai A. Bab -- Bone Repair in Diabetes / Gail Amir -- Cannabinoids in Bone Repair / Itai A. Bab -- Part 3. Bridging of Skeletal Defects and Implants / Mesenchymal Stem Cells for Bone Gene Therapy / Gadi Pelled, Olga Mizrahi, Nadav Kimelman-Bleich and Dan Gazit -- Scaffolds in Skeletal Repair / Erella Livne and Samer Srouji -- Bone Reaction to Implants / David Kohavi.
  • Cancer biotherapy : general principles / Robert K. Oldham -- The pathogenesis of cancer metastasis : relevance to therapy / Sun-Jin Kim ... [et al.] -- Developmental therapeutics and the design of clinical trials / Robert K. Oldham -- Recombinant proteins and gnomics in cancer therapy / Kapil Mehta ... [et al.] -- Current concepts in immunology / Robert K. Oldham -- Therapeutic approaches to cancer-associated immune suppression / Robert K. Oldham -- Cancer vaccines / Kenneth A. Foon and Malek M. Safa -- Cytokines / Walter M. Lewko and Robert K. Oldham -- Interferons : therapy for cancer / David Goldstein ... [et al.] -- Monoclonal antibody therapy / Robert O. Dillman -- Immunotoxins / Arthur E. Frankel, Jung-Hee Woo, and David M. Neville -- Drug immunoconjugates / Malek Safa, Kenneth A. Foon, and Robert K. Oldham -- Targeted radionuclide therpy of cancer / John M. Pagel ... [et al.] -- Stem cell/bone marrow transplantation as biotherapy / Robert K. Oldham -- Cellular immunotherapy (CI), where have we been and where are we going? / John R.Yanelli -- Growth and differentiation factors as cancer therapeutics / Kapil Mehta, Robert K. Oldham, and Bulent Ozpolat -- Granulocyte colony-stimulating factor : biology and clinical potential / MaryAnn Foote and George Morstyn -- Granulocyte-macrophage colony-stimulating factor / MaryAnn Foote and George Morstyn -- Cancer gene therapy / Donald J. Buchsbaum ... [et al.] -- Regulatory process for approval of biologicals for cancer therapy / Antonio J. Grillo-López -- Cancer biotherapy : 2009 disease-related activity / Robert K. Oldham and Robert O. Dillman -- Biological therapy of melanoma / Robert K. Oldham -- Biological therapy of genitourinary cancer / Robert K. Oldham -- Biological therapy of colon cancer / Robert O. Dillman -- Biological therapy of breast cancer / Robert O. Dillman -- Biological therapy of lung cancer / Robert O. Dillman -- Biological therapy of B and T cell lymphoproliferative disorders / Robert O. Dillman -- Biological therapy of multiple myeloma / Robert K. Oldham -- Biological therapy of squamous cell cancers of the head and neck / Robert O. Dillman -- Biological therapy of glioblastoma / Robert O. Dillman -- Speculations for 2009 and beyond / Robert K. Oldham.
  • Plastic surgery: a component in the comprehensive care of cancer patients -- The principles of cancer reconstruction -- Breast reconstruction: timing and coordination with adjuvant therapy -- Breast reconstruction: autogenous tissue -- Breast reconstruction: implant and nipple reconstruction -- Skin cancer and reconstruction -- Lip, cheek, and scalp reconstruction -- Reconstruction of mandible, maxilla, and skull base -- Pharynx, cervical esophagus, and oral cavity reconstruction -- Concepts in nasal reconstruction -- Extremity reconstruction -- Abdominal wall tumors and their reconstruction -- Reconstruction of the intra-abdominal pelvis and the perineum -- Management of chemotherapeutic agent extravasation and radiation therapy adverse effects.
  • First things first -- The frontal CXR -- The lateral CXR -- Heart size assessment -- Pulmonary vasculature and pulmonary embolism -- Heart failure -- The thoracic aorta -- Localizing prosthetic valves -- Mechanical prosthetic valves -- Bio-prosthetic valves -- Annuloplasty rings -- Prosthetic valve dysfunction -- Aortic stents and percutaneous aortic valves -- Radiographic findings by diagnosis : cardiomyopathies -- Radiographic findings by diagnosis : valve cardiovascular disease -- Radiographic findings by diagnosis : pericardial diseases -- Radiographic findings by diagnosis : CAD- complications of infarction -- Radiographic findings by diagnosis : congenital- situs and shunts -- Radiographic findings by diagnosis : congenital abnormalities- pulmonary stenosis -- Radiographic findings by diagnosis : complex congenital abnormalities -- Radiographic findings by diagnosis : other congenital abnormalities -- Central venous and pulmonary artery catheters -- Pacemakers and ICDs -- Percutaneous and surgically inserted ventricular assist devices -- Tubes & drains -- The ICU and post-op patient -- Cardiac & vascular calcification -- Cardiac and vascular trauma -- Clinical uses of the chest radiograph.
  • Traction forces exerted by adherent cells / by Cynthia A. Reinhart-King and Daniel A. Hammer -- Control of endothelial cell adhesion by mechanotransmission from cytoskeleton to substrate / by Rosalind E. Mott and Brian P. Helmke -- Use of hydrodynamic shear stress to analyze cell adhesion / by David Boettiger -- Cellular tensegrity models and cell-substrate interactions / by Dimitrije Stamenović, Ning Wang, and Donald E. Ingber -- Bond formation during cell compression / by Elena Lomakina and Richard E. Waugh -- Dynamics of the neutrophil surface during emigration from blood / Thomas R. Gaborski and James L. McGrath -- Glycocalyx regulation of cell adhesion / Philippe Robert, Laurent Limozin, Anne-Marie Benoliel, Anne Pierres, and Pierre Bongrand -- Atomistic modeling of protein adsorption to ceramic biomaterials in water: a first step toward realistic simulation of the biomaterials surface in vivo / by Alan H. Goldstein -- Model cell membrane surfaces for measuring receptor-ligand interactions / by Craig D. Blanchette, Timothy V. Ratto, and Marjorie L. Longo -- A flow chamber for capillary networks: leukocyte adhesion in capillary sized, ligand-coated micropipettes / by David F.J. Tees, Prithu Sundd, and Douglas J. Goetz -- Adhesion of flowing neutrophils to model vessel surfaces: constraint and regulation by the local hemodynamic environment / Gerard B. Nash and G. Ed Rainger -- Hydrodynamic interactions between cells on reactive surfaces / Dooyoung Lee and Michael R. King -- Dynamics of platelet aggregation and adhesion to reactive surfaces under flow / Nipa A. Mody and Michael R. King.
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  • Basic Principles of Cancer Genetics / Leif W. Ellisen and Daniel A. Haber -- Principles of Cancer Genetic Counseling and Genetic Testing / Kristen M. Shannon and Devanshi Patel -- Genetics of Hereditary Breast Cancer / Paula D. Ryan -- Surgical Management of Hereditary Breast and Ovarian Cancer / Michelle C. Specht, Marcela G. del Carmen and Barbara L. Smith -- Hereditary Colon Cancer: Colonic Polyposis Syndromes / Andrew T. Chan and Daniel C. Chung -- Hereditary Colon Cancer: Lynch Syndrome / Eunice L. Kwak and Daniel C. Chung -- Hereditary Pancreatic Cancer / Janivette Alsina and Sarah P. Thayer -- Hereditary Diffuse Gastric Cancer / Prakash K. Pandalai and Sam S. Yoon -- Familial Renal Cell Cancers and Pheochromocytomas / Gayun Chan-Smutko and Othon Iliopoulos -- Familial Atypical Mole Melanoma (FAMM) Syndrome / Elizabeth D. Chao, Michele J. Gabree and Hensin Tsao -- Multiple Endocrine Neoplasia / Yariv J. Houvras and Gilbert H. Daniels -- Pediatric Malignancies: Retinoblastoma and Wilms' Tumor / David A. Sweetser and Eric F. Grabowski -- Neurofibromatosis and Schwannomatosis / Miriam J. Smith and Scott R. Plotkin -- The HapMap Project and Low-Penetrance Cancer Susceptibility Alleles / Edwin Choy and David Altshuler -- Somatic Genetic Alterations and Implications for Targeted Therapies in Cancer (GIST, CML, Lung Cancer) / Alice T. Shaw, Eyal C. Attar, Edwin Choy and Jeffrey Engelman.
  • Part I. Basic Concepts and Background. History of Clinical Cytogenetics / Steven L. Gersen -- DNA, Chromosomes, and Cell Division / Martha B. Keagle -- Human Chromosome Nomenclature: An Overview and Definition of Terms / Marilyn L. Slovak, Aaron Theisen, Lisa G. Shaffer -- Part II. Examining and Analyzing Chromosomes. Basic Cytogenetics Laboratory Procedures / Martha B. Keagle, Steven L. Gersen -- The Essentials of Light Microscopy / Nathan S. Claxton, Stephen T. Ross -- Quality Control and Quality Assurance / Martha B. Keagle -- Instrumentation in the Cytogenetics Laboratory / Steven L. Gersen -- Part III. Clinical Cytogenetics. Autosomal Aneuploidy / Jin-Chen C. Wang -- Structural Chromosome Rearrangements / Kathleen Kaiser-Rogers, Kathleen W. Rao -- Sex Chromosomes, Sex Chromosome Disorders, and Disorders of Sex Development / Cynthia M. Powell -- The Cytogenetics of Infertility / Linda Marie Randolph -- Prenatal Cytogenetics / Linda Marie Randolph -- The Cytogenetics of Spontaneous Abortion / Solveig M. V. Pflueger, -- Chromosome Instability / Xiao-Xiang Zhang, -- Part IV. Cancer Cytogenetics. The Cytogenetics of Hematologic Neoplasms / Aurelia Meloni-Ehrig -- The Cytogenetics of Solid Tumors / Linda D. Cooley, Kathleen S. Wilson -- Part V. Adjunct Technologies -- Fluorescence In Situ Hybridization (FISH) / Daynna J. Wolff -- Microarray-Based Cytogenetics / Lisa G. Shaffer -- Part VI. Beyond Chromosomes. Fragile X--A Family of Disorders: Changing Phenotype and Molecular Genetics / Elaine B. Spector -- Genomic Imprinting and Uniparental Disomy / Jin-Chen C. Wang -- Genetic Counseling / Sarah Hutchings Clark.
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  • Principles of Cloning, Second Edition is the fully revised edition of the authoritative book on the science of cloning. The book presents the basic biological mechanisms of how cloning works and progresses to discuss current and potential applications in basic biology, agriculture, biotechnology, and medicine. Beginning with the history and theory behind cloning, the book goes on to examine methods of micromanipulation, nuclear transfer, genetic modification, and pregnancy and neonatal care of cloned animals. The cloning of various species-including mice, sheep, cattle, and non-mammals-is considered as well.

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