search indicatorNeed Help? Search Tools



  • This quick reference guide for medical students and residents presents over sixty clinical case studies of major neurological conditions and their associated neuroimaging characteristics. A primer on the fundamental physics which underlie neuroimaging techniques is also provided. The content is organized by pathology type and the structure of every topic is similar to help the reader develop his or her thinking process in a stepwise fashion and to provide a rational approach to imaging interpretation. Neuroradiology in Clinical Practice is aimed at medical students and residents doing their rotations in neurology, internal medicine, emergency medicine, and family medicine, but will also be useful for allied health professionals, nurse practitioners, physician assistants and other primary medical care providers.
  • Print Material
  • Techniques in neuroimaging -- Cranial anatomy -- Neoplasms of the brain -- Vascular diseases of the brain / Robert D. Zimmerman -- Head trauma -- Infectious and noninfectious inflammatory diseases of the brain -- White matter diseases -- Neurodegenerative diseases and hydrocephalus -- Congenital disorders of the brain and spine -- Orbit -- Sella and central skull base -- Temporal bone -- Sinonasal disease -- Mucosal disease of the head and neck -- Extramucosal diseases of the head of and neck -- Anatomy and degenerative diseases of the spine -- Nondegenerative diseases of the spine -- Approach and pitfalls in neuroimaging.
  • Computed Tomography Hyperdense Lesions -- T1 Hyperintense Lesions -- Multiple Susceptibility Artifact Lesions -- Ring-Enhancing Lesions -- Leptomeningeal Enhancement -- Dural Enhancement -- Lesions Containing Fat -- Extraaxial Lesions -- Bilateral Central Gray Matter Abnormality -- Temporal Lobe Lesions -- Temporal Lobe Cystic Lesions -- Cerebellopontine Angle Cisterns -- Lateral Ventricular Lesions -- Third Ventricular Lesions -- Fourth Ventricular Lesions -- Suprasellar Cystic Lesions -- Pineal Region -- Cranial Nerve Lesions -- Lytic Skull Lesions -- Skull Fracture Versus Sutures -- Clivus Lesions -- Hyperdense Cerebellum -- T2 Hyperintense Pontine Abnormalities -- Cerebral Cortical Neurodegeneration -- Cerebral Subcortical Neurodegeneration -- Epidermoid Versus Arachnoid Cyst -- Cyst with a Mural Nodule -- Ecchordosis Physaliphora Versus Chordoma -- Atlantooccipital and Atlantoaxial Separation -- Basilar Invagination and Platybasia -- Enhancing Intramedullary Spinal Cord Lesions -- Enhancing Intramedullary Conus Lesions -- Solitary Enhancing Intradural, Extramedullary Lesions -- Multiple Enhancing Intradural, Extramedullary Lesions -- Cystic Intradural Extramedullary Lesions -- Nerve Root Enlargement -- Posterior Element Lesions -- Sacral Masses -- Disk Infection Versus Inflammatory/Degenerative Changes -- Vertebral Compression Fractures -- Periauricular Cystic Lesions -- Cystic Lateral Neck Masses -- Infrahyoid Neck Cystic Lesions -- Prestyloid Parapharyngeal Space -- Poststyloid Parapharyngeal Space -- Floor of Mouth -- Thyroglossal Duct Abnormalities -- Anterior Skull Base Masses -- Petrous Apex -- External Auditory Canal -- Middle Ear -- Lesions of the Facial Nerve -- Lytic/Cystic Mandibular Lesions -- Jugular Foramen Lesions -- Optic Nerve Mass -- Dilated Superior Ophthalmic Vein/Asymmetric Cavernous Sinus Enhancement -- Lacrimal Gland -- Nasal Cavity Lesions -- Solitary Parotid Masses -- Bilateral Parotid Masses -- Retropharyngeal Space -- Intraventricular Posterior Fossa Tumors -- Pediatric Cerebellar Tumors -- Pediatric Extraaxial Posterior Fossa Tumors -- Midline Posterior Fossa Extraaxial Cystic Lesions -- Occipital Cephalocele -- Holoprosencephaly -- Leukodystrophies -- Congenital Arterial Anastomosis -- Odontoid: Acute Versus Chronic -- Pediatric Nasofrontal Mass -- Pediatric Globe Lesions.
  • Introduction: rationale for robot use -- Part I: Basic framework -- Part II: How do we apply technology (robots) for treatment challenges and limitations: a theoretical framework -- Part III: Robots for upper extremity recovery in stroke/spinal cord injury: technological aspects -- Part IV: Robots for upper extremity recovery in stroke/spinal cord injury: clinical applications -- Part V: Robotics for lower extremity (locomotion): technological aspects -- Part VI: Robotics for lower extremity (locomotion): clinical applications -- Part VII: Specifics aspects of neurorehabilitation technology: robots versus passive systems -- Part VIII: Specifics aspects of neurorehabilitation technology: lower extremity robots -- Part IX: Specifics aspects of neurorehabilitation technology: restoration of bladder function after stroke/spinal cord injury -- Epilogue: what lies ahead.
  • Print Material
    Introduction -- Overview of the nervous system: structures and functions -- The structure of nerve cells and their supporting tissues -- Electrical transmission in the nervous system -- Chemical transmission and the mechanism of drug action -- Sensation -- Vision and the eye -- Vision: central mechanisms -- Audition -- Somesthesis and vestibular sense -- Chemical, heat, and electrical senses -- Reflexes -- Brain control of movement -- Learning and memory -- Motivation -- Language and the brain -- Neurological disease -- Personality and emotion -- Mental illness and the history of surgical and drug treatment -- Consciousness and the techniques for study of the human brain -- Conclusion.
  • Print Material
  • Edited and authored by a wealth of international experts in neuroscience and related disciplines, the aim behind this key new resource is to offer medical students and graduate researchers around the world a comprehensive introduction and overview of modern neuroscience. Neuroscience research is certain to prove a vital element in combating mental illness in its various incarnations, a strategic battleground in the future of medicine, as the prevalence of mental disorders is becoming better understood each year. Hundreds of millions of people worldwide are affected by mental, behavioral, neurological and substance use disorders. The World Health Organization estimated in 2002 that 154 million people globally suffer from depression and 25 million people from schizophrenia; 91 million people are affected by alcohol use disorders and 15 million by drug use disorders. A more recent WHO report shows that 50 million people suffer from epilepsy and 24 million from Alzheimer's and other dementias. Because neuroscience takes the etiology of disease--the complex interplay between biological, psychological, and sociocultural factors--as its object of inquiry, it is increasingly valuable in understanding an array of medical conditions. A recent report by the United States' Surgeon General cites several such diseases: schizophrenia, bipolar disorder, early-onset depression, autism, attention deficit/ hyperactivity disorder, anorexia nervosa, and panic disorder, among many others. Not only is this volume a boon to those wishing to understand the future of neuroscience, it also aims to encourage the initiation of neuroscience programs in developing countries, featuring as it does an appendix full of advice on how to develop such programs. With broad coverage of both basic science and clinical issues, comprising 106 chapters from a diversity of international authors and including complementary video components, Neuroscience in the 21st Century will serve as a comprehensive resource to students and researchers alike.
  • Neurogenetics of Aggressive Behavior -- Studies in Rodents -- Neurogenetics of Aggressive Behavior -- Studies in Primates -- Glucocorticoids and Escalated Aggressive Behavior.-Models of Female Aggression -- Prefrontal Cortex.-Nitric Oxide, Serotonin and Aggression -- Hypothalamus and Aggressive Behavior -- Vasopressin-Serotonin Interactions in Aggressive Behavior -- Dopamine-oxytocin: Attachment and Conflict -- Stress and violence.-Gene-environment interactions and violence.-MAO-A and genetic risk for violence -- The development of violent behavior in humans -- Schizophrenia and violence.-Psychopathy -- Violent and callous behavior in children -- Aggression in Children and Adolescents-Alcohol and Aggression.
  • "Neuroscience of Clinical Psychiatry, Second Edition Fully revised and updated in its Second Edition, this handy and accessible reference provides a basic link between the science of the brain and the treatment of common mental health disorders. Ideal for the mental health clinician in training, the psychiatric resident preparing for Board exams, and the practicing clinician looking to keep pace with the latest advances in neuroscience, the book uses clear and direct language to enhance your understanding of basic neuroscientific concepts and the effects of brain chemistry on common behaviors and disorders. Updated content reflects the latest advances in the field, while straightforward discussions make complex material easy to understand and process. The book's concise presentation helps readers grasp, retain, and apply essential concepts. Abundant illustrations and tables support the text and provide vital information at a glance. End-of-chapter review questions reinforce key concepts and assist in Board preparation. Look inside and discover... Updated content reflects the latest advances in the field. Straightforward discussions make complex material easy to understand and process. Concise presentation helps you grasp, retain, and apply essential concepts. Abundant illustrations and tables support the text and provide vital information at a glance. End-of-chapter review questions reinforce key concepts and assist in Board preparation. Pick up your copy today! "-- Provided by publisher.
  • Part I: The Basics of Hallucinations -- An Epistemological Approach: History of Concepts and Ideas About Hallucinations in Classical Psychiatry -- Hallucinatory Experiences in Non-clinical Populations -- Hallucinations and Other Sensory Deceptions in Psychiatric Disorders -- Hallucinations Associated with Neurological Disorders and Sensory Loss -- Standardized Assessment of Hallucinations -- Part II: Cognitive Models of Hallucinations -- The "Bottom-Up" and "Top-Down" Components of the Hallucinatory Phenomenon -- Speech Processing and Auditory Hallucinations -- The Role of Memory Retrieval and Emotional Salience in the Emergence of Auditory Hallucinations -- Misattributions Models (I): Metacognitive Beliefs and Hallucinations -- Misattribution Models (II): Source Monitoring in Hallucinating Schizophrenia Subjects -- Time Perception and Discrimination in Individuals Suffering from Hallucinations -- Part III: Neurobiological and Computational Models of Hallucinations -- A Neurodevelopmental Perspective on Hallucinations -- Candidate Genes Involved in the Expression of Psychotic Symptoms: A Focus on Hallucinations -- Animal Models and Hallucinogenic Drugs -- Cannabis and Hallucinations: Studies in Human Subjects -- Computational Models of Hallucinations -- Part IV: Brain-Imaging Insight into Hallucinations -- Electrophysiological Exploration of Hallucinations (EEG, MEG) -- Structural Imaging of the "Hallucinating" Brain in Schizophrenia -- Functional Brain Imaging of Auditory Hallucinations: From Self-Monitoring Deficits to Co-opted Neural Resources -- Functional Brain Imaging of Hallucinations: Symptom Capture Studies -- Brain Functioning When the Voices Are Silent: Aberrant Default Modes in Auditory Verbal Hallucinations -- Connectivity Issues of the 'Hallucinating' Brain -- Part V: Innovative Therapeutic Approaches of Hallucinations -- Beyond Monotherapy: The HIT Story -- The Psychopharmacology of Hallucinations: Ironic Insights into Mechanisms of Action -- Neuromodulation Techniques to Treat Hallucinations -- The Future of Brain Stimulation to Treat Hallucinations -- Perspectives in Brain Imaging and Computer-Assisted Technologies for the Treatment of Hallucinations -- Conclusion: Key Issues for Future Research in the Neuroscience of Hallucinations.
  • The neurobiology of preferences / Mkael Symmonds and Raymond J. Dolan -- Models of value and choice / Peter Dayan -- Predicting emotional reactions: mechanisms, bias and choice / Tali Sharot -- The evolution of our preferences: insights from non-human primates / Venkat Lakshminarayanan and Laurie R. Santos -- The effect of context on choice and value / Benedetto de Martino -- Preference change through choice / Petter Johansson, Lars Hall and Nick Chater -- Set-size effects and the neural representation of value / Kenway Louie and Paul W. Glimcher -- Social factors and preference change / Daniel Campbell-Meiklejohn and Chris D. Frith -- Social and emotional factors in decision-making: appraisal and value / Elizabeth A. Phelps and Peter Sokol-Hessner -- Auditory preferences and aesthetics: music, voices, and everyday sounds / Josh H. McDermott -- The flexibility of chemosensory preferences / Géraldine Coppin and David Sander -- Dynamic preference formation via gaze and memory / Hsin-I Liao and Shinsuke Shimojo -- Choice sets as percepts / Andrew Caplin -- Preferences and their implication for policy, health and wellbeing / Ivo Vlaev and Ara Darzi.
  • Neuroscience of sleep 2009
    Section I: Introduction. History of sleep research / R. Pelayo and C. Guilleminault -- Section II: Definitions and descriptions of sleep. Sleep architecture / E. F. Pace-Schott ; Behavior and parasomnias (RSBD) / M. W. Mahowald, M. A. Cramer-Bornemann, and C. H. Schenck ; Sleep oscillations and PGO waves / M. Steriade ; PET activation patterns / T. T. Dang-Vu, M. Desseilles, P. Peigneux, S. Laureys, and P. Maquet ; Hippocampal-neocortical dialog / J. J. Chrobak, A. Sirota, and G. Buzáski ; Network reactivation / S. Ribeiro and M. Nicolelis ; Gene expression / C. Cirelli and G. Tononi -- Section III: Ontogeny and phylogeny of sleep. Phylogeny and ontogeny of sleep / J. A. Lesku, D. Martinez-Gonzalez, and N. C. Rattenborg ; Sleep in adolescents / I. Tarokh and M. A. Carskadon ; Sleep in aging / M. Rissling and S. Ancoli-Israel -- Section IV: Control of sleep and sleep states. Thalamic regulation of sleep / A. Destexhe and T. J. Sejnowski ; Hypothalamic regulation of sleep / P. M. Fuller and J. Lu ; Histamine / H. L. Haas, O. Selbach, and O. A. Sergeeva ; Cytokines and other neuromodulators / J. M. Krueger, L. Churchill, and D. M. Rector ; Locus coeruleus and Raphe nucleus / B. E. Jones ; Acetylcholine / B. E. Jones ; Dopamine / P. M. Fuller and J. Lu -- Section V: Sleep and arousal states. Reticular activating system / E. Garcia-Rill ; Nightmares / M. Schredl ; Coma / S. Laureys, M. Boly, G. Moonen, and P. Maquet -- Section VI: Circadian. Circadian regulation by the suprachiasmatic nucleus / D. J. Earnest ; Sleep: development and circadian control / H. C. Heller and M. G. Frank ; Sleep and waking in drosophila / C. Cirelli and G. Tononi ; Genetics of circadian disorders in humans / A.-M. Chang and P. C. Zee ; Circadian rhythms in sleepiness, alertness, and performance / J. D. Minkel and D. F. Dinges -- Section VII: Pharmacology of sleep. Modafini, amphetamines, and caffeine / C. Ballas and D. F. Dinges ; Adenosine / R. Basheer, J. T. McKenna, and R. W. McCarley -- Section VIII: Sleep function. Endocrine function during sleep and sleep deprivation / J. M. Mullington ; Immune function during sleep and sleep deprivation / J. M. Mullington ; Thermoregulation during sleep and sleep deprivation / R. Szymusiak ; Autonomic dysregulation during REM sleep / S. M. Caples and V. K. Somers ; Sleep-dependent memory processing / M. P. Walker ; Behavioral change with sleep deprivation / J. D. Minkel, S. Banks, and D. F. Dinges ; Sleep deprivation and brain function / S. P. A. Drummond and B. S. McKenna ; Napping / S. C. Medrick and S. P. A. Drummond -- Section IX: Sleep disorders. Sleep apnea / S. C. Veasey ; Narcolepsy / E. Mignot and L. Lin ; Cataplexy / S. Nishino ; Sleeping sickness / M. Bentivoglio and K. Kristensson -- Section X: Dreaming. Theories of dream function / D. Kuiken ; Sleep and consciousness / J. A. Hobson ; REM/REM differences in dream content / J. S. Antrobus and E. J. Wamsley ; Dreams and nightmares in PTSD / A. Germain and A. Zadra ; Theories and correlates of nightmares / T. Nielsen and R. Levin ; Incorporation of waking events into dreams / E. J. Wamsley and R. Stickgold.
  • Print Material
  • Print Material
    High-yield facts -- Gross anatomy of the brain -- Development -- The neuron -- The synapse -- Neurochemistry/neurotransmitters -- The spinal cord -- The autonomic nervous system -- The brainstem and cranial nerves -- Sensory systems -- Anatomy of the forebrain0 -- Motor systems -- Higher functions.
  • Print Material
    High Yield Facts -- Gross Anatomy of the Brain -- Development -- Anatomical and Functional Properties of Neurons and Muscle -- The Synapse -- Neurochemistry / Neurotransmitters -- The Spinal Cord -- The Autonomic Nervous System -- The Brainstem and Cranial Nerves -- Sensory Systems -- Anatomy of the Forebrain -- Motor Systems -- Higher Functions.
  • Print Material
    High-yield facts -- Gross anatomy of the brain -- Development -- Anatomical and functional properties of neurons and muscle -- The synapse -- Neurochemistry/Neurotransmitters -- The spinal cord -- The autonomic nervous system -- The brainstem and cranial nerves -- Sensory systems -- Anatomy of the forebrain -- Motor systems -- Higher functions.
  • "Neuroscience, Consciousness and Spirituality presents a variety of perspectives by leading thinkers on contemporary research into the brain, the mind and the spirit. This volumes aims at combining knowledge from neuroscience with approaches from the experiential perspective of the first person singular in order to arrive at an integrated understanding of consciousness. Individual chapters discuss new areas of research, such as near death studies and neuroscience research into spiritual experiences, and report on significant new theoretical advances. From Harald Walach's introductory essay, "Neuroscience, Consciousness, Spirituality--Questions, Problems and Potential Solutions," to the concluding chapter by Robert K. C. Foreman entitled "An Emerging New Model for Consciousness: The Consciousness Field Model," this book represents a milestone in the progress towards an integrated understanding of spirituality, neuroscience and consciousness. It is the first in a series of books that are dedicated to this topic."--Publisher's website.
  • Print Material
    Organization of the nervous system -- Neuron excitation -- Synapses -- Neurotransmitters -- Neural coding -- Somatosensory systems -- Vision -- Hearing -- Smell and taste -- Motor function: spinal cord and brainstem -- Movement: cortex, cerebellum and basal ganglia -- Neuroendocrinology and autonomic functions -- Brain and behavior -- Developmental neurobiology -- Memory and cognition -- Brain disorders.
  • Although, within neurosonology, study of both the extracranial and the intracranial circulation began at least 15 years ago, it is only in recent years that ultrasound evaluation of cerebral veins and cerebral venous hemodynamics has attracted wider attention. Nevertheless, the huge variability in venous outflow pathways in normal subjects means that the potential usefulness of this examination is still often neglected. This atlas provides concise descriptions of the main normal and pathological ultrasound features of the cerebral venous circulation for neurosonologists and clinicians. It is designed as a practical tool that will be of assistance in everyday practice in the ultrasound lab and will improve the knowledge of sonologists and the reliability of venous ultrasound studies. The multimedia format, with detailed images, explanatory videos, and short, targeted descriptions, ensures that information is clearly conveyed and that users will become fully acquainted with the variability of normal findings of venous examinations. The atlas will be of value both to trainees in this field of ultrasound and to neurosonologists who are beginning to perform venous examinations in addition to arterial extra- and intracranial examinations.
  • Stroke is the most common neurological disease. Although the clinical findings that present in various kinds of stroke are often very similar, there is a wide variety of causes. An effective and specific therapy requires consideration of the etiology of the stroke incident. The cases presented in this book originate from one of the top worldwide stroke clinics--Charite, Berlin--and using imaging studies from all modalities as well as clinical information, the reader is guided to a better understanding of the process of stroke, its diagnosis, and effective means of therapy.
  • The power and promise of neurostereology / Peter R. Mouton -- Stereological estimation of brain volume and surface area from MR images / Niyazi Acer and Mehmet Turgut -- Cell proliferation in the brains of adult rats exposed to traumatic brain injury / Sandra A. Acosta, Naoki Tajiri, Paula C. Bickford, and Cesar V. Borlongan -- Age-effects in substantia nigra of Asian Indians / Phalguni Anand Alladi -- Design-based stereology in the brain bank setting / Mark Burke -- Practical stereology for preclinical neurotoxicology / Mark T. Butt -- An overabundance of prefrontal cortex neurons underlies early brain overgrowth in autism / Eric Courchesne and Peter R. Mouton -- Order in chaos : stereological studies of nervous tissue / Peter Dockery -- Comparative stereology studies of brains from marine mammals / Nina Eriksen and Bente Pakkenberg -- Quantitative assessment of hippocampus architecture using the optical disector / Shozo Jinno -- The possible applications (and pitfalls!) of stereological analysis in post-mortem brain research / Ahmad A. Khundakar and Alan J. Thomas -- Visualisation of blood vessels in two-dimensional and three-dimensional environments for vascular stereology in the brain / Zerina Lokmic -- Blood flow analysis in epilepsy using a novel stereological approach / Rocio Leal-Campanario, Luis Alarcon-Martinez, Susana Martinez-Conde, Michael Calhoun, and Stephen Macknik -- AD-type neuron loss in transgenic mouse models / Kebreten F. Manaye and Peter R. Mouton -- Quantification in populations of non-uniformly distributed cells in the human cerebral cortex / William L. Maxwell -- The effects of high-fat diet on the mouse hypothalamus : a stereological study / Mohammad Reza Namavar, Samira Raminfard, Zahra Vojdani Jahromi, and Hassan Azari -- 2-D and 3-D morphometric analyses comparing three rodent models / JiHyuk Park and S. Omar Ahmad -- A stereologic perspective on autism neuropathology / Neha Uppal and Patrick R. Hof.
  • While steroids from the periphery have profound effects on the nervous system, the nervous system also produces its own steroids de novo ("neurosteroids"). The physiological importance of neurosteroids is beginning to be understood. These steroids potentially have roles in sedative/hypnotic behavior, anxiety, learning, and memory. At the cellular level, neurosteroids affect neuronal excitability, synaptic plasticity and cell proliferation and survival. Early findings hold promise for future strategies to treat specific psychological conditions and neurological diseases. This Brief will focus on the current state of understanding of brainderived neurosteroids.
  • History of Neurostimulation -- Mechanisms of Spinal Neuromodulation -- Medical Considerations in Spinal Cord Stimulation -- Patient Selection: Psychological Considerations -- Spinal Cord Stimulation: General Indications -- Spinal Cord Stimulation: Implantation Techniques -- Spinal Cord Stimulation: Parameter Selection and Equipment Choices -- Spinal Cord Stimulation as a Treatment of Failed Back Surgery Syndrome -- Neurostimulation in Complex Regional Pain Syndrome -- Spinal Cord Stimulation for Peripheral Vascular Disease -- Spinal Cord Stimulation for Refractory Angina and Peripheral Vascular Disease -- Spinal Cord Stimulation for Visceral Abdominal Pain -- Nerve Root, Sacral, and Pelvic Stimulation -- Emerging Indications and Other Applications of Spinal Cord Stimulation -- Complications of Spinal Cord Stimulation -- Peripheral Nerve Stimulation -- Peripheral Nerve Stimulation: Open Technique -- Peripheral Nerve Stimulation: Percutaneous Technique -- Occipital Neurostimulation -- Peripheral Subcutaneous Stimulation for Intractable Pain -- Motor Cortex Stimulation for Relief of Chronic Pain -- Deep Brain Stimulation -- Coding and Billing for Neurostimulation -- Cost-Effectiveness of Neurostimulation -- The Future of Neurostimulation.
  • Deep brain stimulation (DBS) mechanisms of action / Erwin B. Montgomery Jr. -- Overview of DBS components / Sam Eljamel -- DBS in Parkinson's disease (PD) : subthalamic nucleus (STN) DBS / Manish Ranjan and Christopher R. Honey -- Pallidal (GPi) DBS / Yasuaki Harasaki and Steven Ojemann -- DBS of the pedunculopontine nucleus (PPN) for PD / Aviva Abosch and Amit Goyal -- DBS in tremor / Antonios Mammis and Michael Schulder -- Deep brain stimulation in dystonia / Ludvic Zrinzo -- DBS in epilepsy / Michael G. Kaplitt -- DBS in obsessive compulsive disorders (OCD) / David Christmas and Loes Gabriëls -- DBS in treatment of refractory major depression (TRMD) / Clement Hamani and Paul E. Holtzheimer -- DBS in pain syndromes / Alexander Green -- DBS in cluster headache / Giovanni Broggi, Giuseppe Messina, Angelo Franzini -- Mechanism of action and overview of VNS technology / Sam Eljamel -- VNS in epilepsy / Ian Morrison -- VNS in TRMD / Christine Matthews, Serenella Tolomeo, Keith Matthews -- Mechanism of action and overview of MCS components / Sam Eljamel -- MCS in refractory pain / Giovanni Broggi ... [et al.] -- Mechanism of action and overview of SCS components / Sam Eljamel -- SCS in failed back surgery syndrome (FBSS) / Gail Gillespie and Pravin Dandegaonkar -- SCS in complex regional pain syndrome (CRPS) / Eduardo Goellner & Konstantin Slavin -- SCS in other indications / Konstantin V. Slavin and Sam Eljamel -- PNS in head and face pain / Konstantin V. Slavin, Serge Y. Rasskazoff, Sami Al-Nafi -- PNS in pain of the body and extremities / Konstantin V. Slavin, Sami Al-Nafi, Serge Y. Rasskazoff.
  • Neurosurgery 2005
    Neurophysiology -- Neuroradiology and ultrasound -- Neuropathology -- Neuroanesthesia -- Neurosurgical intensive care -- Neuroendoscopy -- Principles and practice of image-guided neurosurgery -- Stereotactic radiosurgery -- Low-grade gliomas in adults -- Neurosurgical management of high-grade gliomas -- Sellar and parasellar tumors -- Meningiomas -- Intraventricular and pineal region tumors -- Cerebello-pontine angle tumors -- Skull base tumors -- Tumors: cerebral metastases and lymphoma -- Cerebral blood flow: physiology and measurement techniques -- Aneurysmal subarachnoid hemorrhage --Interventional neuroradiology -- Arteriovenous malformations -- Management of severe head injury -- Spine injuries -- Rehabilitation of neurologically injured patients -- Hydrocephalus and shunts -- Craniosynostosis -- Syndromic craniosynostosis -- Spinal dysraphism -- Pediatric neuro-oncology -- Management of spinal tumors -- Management of extradural spinal tumors -- Degenerative disease of the cervical spine -- Peripheral and cranial nerve injury -- Pain -- Epilepsy surgery -- Functional neurosurgery for movement disorders -- Infections in the central nervous system -- Infections in neurological surgery -- Ischemic stroke and carotid endarterectomy.
  • Neurosurgery 2010
  • Neurosurgery -- Clinical neurology -- Neuroanatomy -- Neurobiology -- Neuropathology -- Neuroradiology -- Clinical skills/critical care -- Neurosurgery -- Clinical neurology -- Neuroanatomy -- Neurobiology -- Neuropathology -- Neuroradiology -- Clinical skills/critical care.
  • An ideal resource for board exam preparation, this review distills the essentials of neurosurgery in a user-friendly question and answer format. Divided into three main sections, this text presents a comprehensive collection of cases covering intracranial pathology, spinal and peripheral nerve pathology, and neurology. Each chapter opens by detailing the clinical presentation of a problem frequently encountered in everyday practice followed by a list of questions and answers designed to test the reader's knowledge of diagnostic techniques, imaging, surgical indications, treatment options, potential complications, and outcomes. This book is an indispensable tool for neurosurgeons, residents, and fellows preparing for their oral board or recertification examinations. With its highly accessible presentation, this book will also be a valuable refresher for clinicians and a useful reference for students preparing for rounds.
  • "The book is devoted to the neurosurgical management of spasticity. Starting with a chapter on the anatomical and physiological foundations of spasticity and a short history of its neurosurgical treatment, it describes the neurosurgical methods currently available. As management differs between adults and children, the book is also structured accordingly, including evaluation, decision-making, Intrathecal Baclofen Therapy (ITB), botulinum toxin therapy, and surgery. Beyond ITB, the neurosurgical options covered include procedures focusing on the peripheral nerves, dorsal roots, Dorsal Root Entry Zone and spinal cord. Based on surgical experience collected with more than a thousand patients, the book gathers the most important aspects of our present understanding, presented using a practical, educational approach. It stresses the importance of a multidisciplinary approach, including neurologists, pediatricians and rehabilitation specialists. Close collaboration with other surgical disciplines like orthopedic surgery and neuro-urology are also outlined."--Publisher's website.
  • "This book is intended to serve as a supplement to the knowledge gained during the long years of residency and in the early stages of practice. It tried to focus on the major aspects of diseases that a neurosurgeon may encounter, both in clinical practice and on the examination" --Provided by publisher.
  • "Neurosurgery Rounds: Questions and Answers is the first guide dedicated to preparing residents and medical students for the challenging questions -- known as "pimping" in the vernacular -- they will frequently encounter on neurosurgery rotation. Nine succinct chapters fully cover the basic and clinical neurosciences in a convenient Q&A format that is ideal for self-study. Short answers and explanations appear directly below the questions to enable easy reading on the go. Features - Over 1,600 questions and answers quiz readers on a wide range of neurosurgical topics - 30 cases -- also in an accessible Q&A format -- prime readers for clinical situations - More than 150 high-quality radiographs and anatomy drawings supplement the text The perfect size to fit in a lab coat pocket, this concise review will be the constant companion of every medical student on a neurosurgical rotation and every neurosurgery resident or general surgery resident who needs to prepare for rounds or study for board examinations"--Provided by publisher.
  • "Neurosurgery Tricks of the Trade: Cranial presents core surgical procedures in a concise, highly didactic format, enabling surgeons to quickly grasp their essence from the bulleted text and superb illustrations that accompany them. Expert neurosurgeons specializing in the cranial region describe how they perform common procedures and offer surgical tips and pearls. Key Features: - Distills a wealth of information in a concise, step-by-step format, making it easy for novice surgeons to review how procedures are performed - Includes more than 150 surgical procedures for the cranial region, each accompanied by high-quality, original illustrations - Presents topics in either a pathology-based or an approach-based manner - Consistently organizes the procedures into the headings: Introduction and Background, Operative Detail and Preparation, Outcomes and Postoperative Course, and References, enabling rapid reference. Neurosurgeons at all levels, from residents learning procedures to experienced practitioners needing a quick refresher, will find this book, along with its companion volume, Neurosurgery Tricks of the Trade: Spine and Peripheral Nerves, to be an invaluable resource throughout their surgical careers"--Provided by publisher.
  • Neurosurgical emergencies. 2nd ed. 2008
    Thieme eNeurosurgery
    This edition covers the most frequently encountered neurosurgical emergencies caused by disease, infection, trauma, and complications. It presents the current surgical guidelines for managing the full range of neurosurgical emergencies including those involving intracranial, spinal, and peripheral nerve pathology, and neurosurgical problems in pediatric patients. Expert specialists present their clinical insights in easy-to-follow protocols. Concise descriptions enable the reader to rapidly gain a firm understanding of pathogenesis of the problem, classification of injury, evaluation, clinical presentation, imaging, surgical indications, surgical approaches, and prognosis.
  • Good neurosurgical practice is based not only on evidence, skills, and modern equipment, but also on good values. Young surgeons often learn about ethical behavior by observing the behavior of their teachers in different situations, but for several reasons, this is not enough. This book discusses the ethical issues that arise during the daily practice of neurosurgery. It will be especially informative for neurosurgeons, other surgeons, physicians, residents, medical students, and allied health care providers. The book is not a philosophical expose but an easily readable and highly practical road map on how to navigate ethically challenging situations in neurosurgical and other practice. The book is divided into five parts addressing general issues, patients' rights, end of life issues, neurosurgeons' duties, and neurosurgeons and society. The contributing authors are well-established neurosurgeons and other doctors with long experience and from different backgrounds. They discuss ethical problems encountered in everyday practice, introduced by cases, and in all, there are more than 50 neurosurgical cases drawn from real life. The editors introduce in the title and throughout the book the term 'value-based medicine' which reinforces that while modern medicine and surgery have come very far in technical aspects, the core of what we do must be based on the values embodied in bioethics.
  • Immunology of the CNS / Pragati Nigam and Maciej Lesniak -- Microbiological diagnosis of CNS / Yuriko Fukuta and Karin E. Byers -- Antibiotics and development of resistance / Peter D. Kim and Walter A. Hall -- Radiology of infections of the CNS / Kunal M. Patel and Charles L. Truwit -- Viral infections of the CNS -- Joseph B. Domachowske and Manika Suryadevara -- Fungal infections of the CNS / Walter A. Hall and Peter D. Kim -- Parasitic infections of the CNS / Ali Akhaddar and Mohamed Boucetta -- Bacterial brain abscess / Peter D. Kim and Walter A. Hall -- Meningeal infections / Manika Suryadevara and Joseph B. Domachowske -- Epidural and subdural infections / Sandi K. Lam and Peter C. Warnke -- Intracranial vascular infections / Hoon Choi, Walter A. Hall, and Eric M. Deshaies -- Vertebral column infections / Kyle I. Swanson and Daniel K. Resnick -- Spinal canal infections / Ian E. McCutcheon -- Neurosurgical antibiotic prophylaxis / DaraspreetKainth, Dino Terzic, and Stephen J. Haines -- Postoperative intracranial infections / Arya Nabavi, Friederike Knerlich-Lukoschus, and Andreas M. Stark -- Implanted devices and CNS infection / Ramesh Grandhi, Gillian Harrison, and Elizabeth C. Tyler-Kabara -- Pediatric CNS infections / Ian Mutchnick and Thomas Moriarty -- Immune compromise and CNS infections / Ouzi Nissim ... [et al.] -- Systemic infections in neurocritical care / Michael F. Regner ... [et al.].
  • Neurosurgical instrument guide 2012
    Thieme eNeurosurgery
    The operating room -- Operating room equipment -- Basic neurosurgical trays -- Basic neurosurgical instrumentation.
  • Neurosurgical intensive care 2008
    Thieme eNeurosurgery
    Foreword / Charles H. Tator -- Introduction to the neurosurgical intensive care unit / Javed Siddiqi. I. Initial assessment -- Bedside exam in the neurosurgical intensive care unit / John D. Cantando, Daniel Hutton, and Dan Miulli -- Cranial nerve injuries and their management / Nguyen Do and Dan Miulli -- Altered level of consciousness: pathophysiology and management / Jeffery M. Jones and Dan Miulli -- Coma / Jeffery M. Jones and Dan Miulli -- Neuroimaging and the neurosurgical intensive care unit patient / Ganna L. Breland and Dan Miulli -- Lab work: what, when, and how often? / Jon Taveau. II. Triage -- Team management of the multisystem-injured neurosurgical intensive care unit patient / David T. Wong -- The spinal cord-injured patient / Jeffery M. Jones and Dan Miulli -- Progressing postoperative neurologic deficit: cranial or spinal / Ganna L. Breland and Dan Miulli -- Delayed intracerebral hemorrhage / Lynn M. Serrano -- Sedation and pain management in the neurosurgical intensive care unit patient / Dan Miulli. III. Pathophysiology -- Homeostatic mechanisms in the neurosurgical intensive care unit patient / Gayatri Sonti, Dan Miulli, and Javed Siddiqi -- Neurophysiology in the neurosurgical intensive care unit: options, indications, and interpretations / Dennis Cramer, Dan Miulli, and Javed Siddiqi -- Cerebral perfusion / Dan Miulli and Javed Siddiqi -- Cerebrospinal fluid dynamics and pathology / Lynn M. Serrano, John D. Cantando, and Dan Miulli -- Intracranial pressure fundamentals / Daniel Hutton, Javed Siddiqi, and Dan Miulli -- Cerebral protection measures / Dennis Cramer, Dan Miulli, and Javed Siddiqi. IV. Care of the patient -- Neuropharmacology / Nicholas Qandah, Evan A. Houck, and Dan Miulli -- Nutrition / Dan Miulli -- Fluid management / Dan Miulli -- Ventilator management / Dan Miulli and Javed Siddiqi -- Seizure disorders: diagnosis and management / Margaret R. Wacker -- Infections / Darryl M. Warner and Dan Miulli -- Systemic complications / Daniel Hutton and John D. Cantando. V. Specific diseases -- Disease-specific phenomena / John D. Cantando and Javed Siddiqi -- Unique pediatric neurosurgical intensive care unit issues / Lynn M. Serrano and Dan Miulli -- Brain death / Dan Miulli. VI. Nursing issues -- Nursing issues / Paula Snyder -- Restraints and the neurosurgical intensive care unit patient / Paula Snyder. VII. Family issues -- Family communication / Theresa Longo and Dan Miulli -- Spiritual care of the neurosurgical intensive care unit patient and family / John R. Spitalieri -- Medical-legal issues in the neurosurgical intensive care unit / Dan Miulli, Silvio F. Hoshek, and Rosalinda M. Menoni -- Discharge planning in the neurosurgical intensive care unit patient / Paula Snyder.
  • Part of the second edition of the classic Neurosurgical Operative Atlas series, Functional Neurosurgery provides step-by-step guidance on the innovative and established techniques for managing epilepsy, pain, and movement disorders. This atlas covers the current surgical procedures, providing concise descriptions of indications and surgical approaches, as well as recommendations for how to avoid and manage postoperative complications. The authors describe the underlying physiological principles and state-of-the art recording techniques that are used for brain localization. This edition addresses topics that are rarely covered in other texts, including motor cortex stimulation for neuropathic pain, novel technical approaches for insertion of deep brain stimulator electrodes, and radiosurgery for movement disorders.
  • Transsphenoidal approaches to the sella and suprasellar region -- Surgical approaches to craniopharyngiomas -- Eyebrow orbitotomy approach to parasellar tumors -- Expanded endonasal approach to the sella and anterior skull base -- Endoscopic approaches for intraventricular brain tumors -- Surgical approaches to tumors of the third ventricle -- Surgical approaches to intraventricular tumors (lateral ventricles) -- Surgical management of spinal meningiomas -- Surgical management of spinal metastatic tumors: the anterior lumbar approach and the lateral retroperitoneal approach to the thoracolumbar spine -- Surgical management of peripheral nerve tumors -- Surgical management of spinal schwannomas -- Balloon-catheter brachytherapy for malignant brain tumors -- Intraoperative magnetic resonance imaging for brain tumor resection -- Stereotactic resection of malignant brain tumors -- Radiosurgery of intracranial lesions -- Surgical management of meningiomas of the sphenoid wing region: operative approaches to medial and lateral sphenoid wing, spheno-orbital, and cavernous sinus meningiomas -- Surgical management of convexity meningiomas -- Surgical technique for removal of clinoidal meningiomas -- Surgical management of olfactory groove meningiomas -- Petrosal approach for resection of petroclival meningiomas -- Surgical management of tentorial meningiomas -- Surgical management of tuberculum sellae meningiomas -- Surgical management of jugular foramen schwannomas -- Surgical approaches to pineal region tumors -- Surgical approaches to pediatric midline posterior fossa tumors -- Surgical approaches to vestibular schwannomas -- Surgical resection of lower clivus-anterior foramen magnum meningiomas -- Surgical management of trigeminal neuroinomas -- Surgical management of intracranial glomus tumors -- Preauricular transzygomatic subtemporal and infratemporal approaches to the skull base -- Combined craniofacial resection of anterior skull base tumors -- Surgical resection of esthesioneuroblastoma -- Transmaxillary approaches to the clivus -- Surgical management of cholesterol granulomas of the petrous apex -- Transbasal approaches to the skull base and extensions -- Transmandibular approaches to the skull base.
  • Featuring the clinical expertise of leading authorities in the field, this book is a lavishly illustrated surgical atlas of the latest neurosurgical approaches to frequently encountered problems in the pediatric patient. Each chapter in the book opens with a brief overview of the problem and then goes on to provide concise discussions of preoperative preparation, operative procedure, and postoperative management. The authors address the possible complications involved in each procedure and provide recommendations for how to avoid and manage them. 380 full-color illustrations and photographs demonstrate key concepts with precision and clarity. Step-by-step descriptions offer practical guidance for skin incision, operative exposure, patient positioning, surgical approaches, and various closing techniques. Consistent organization throughout the chapters facilitates rapid reference to topics of interest.
  • Section I : Aneurysms/Subarachnoid Hemorrhage -- Aneurysm Surgery Techniques -- Ophthalmic Segment Aneurysms -- Supraclinoid Internal Carotid Artery Aneurysms -- Anterior Communicating Artery Aneurysms -- Distal Anterior Cerebral Artery Aneurysms -- Middle Cerebral Artery Aneurysms -- Anterior Interhemispheric Approach for Anterior Communicating Artery Aneurysms -- Pterional Transsylvian and Extended Approaches for Upper Basilar Aneurysms -- Subtemporal Approach for Basilar and Posterior Cerebral Artery Aneurysms -- Transsylvian Transclinoidal and Transcavernous Approach for Basilar Bifurcation Aneurysms -- Orbitocranial Zygomatic Approach for Upper Basilar Artery Aneurysms -- Cardiac Arrest for Cerebral Aneurysms -- Vertebral Artery and Posterior Inferior Cerebellar Artery Aneurysms -- Transcondylar and Far Lateral Approaches for Aneurysms -- Vertebral Confluence and Midbasilar Aneurysms Including Transpetrosal Approach -- Fusiform, Dolichoectatic, and Dissecting Aneurysms -- Endoscopic Approaches to Aneurysms -- Microsurgical Treatment of Previously Coiled and Endovascularly Treated Aneurysms -- Minimally Invasive Approaches to Aneurysms -- Pterional Craniotomy for Exposure of Contralateral Aneurysms. Section II : Vascular Malformations -- AVM of the Cerebral Convexity -- Arteriovenous Malformations of the Basal Ganglia and Thalamus -- Intraventricular and Deep Arteriovenous Malformations -- Vein of Galen Malformations -- Posterior Fossa Arteriovenous Malformations-- Superficial Cavernous Malformations -- Angiographically Occult Vascular Malformations of the Brain Stem Thalamus, and Basal Ganglia -- Spinal Vascular Malformations -- Carotid Cavernous Fistulas -- Dural Arteriovenous Malformations -- Tentorial and Posterior Fossa Dural Arteriovenous Malformations -- Anterior Fossa, Superior Sagittal Sinus, and Convexity Dural Arteriovenous Malformations. Section III : Ischemic and Other Cerebrovascular Disease -- Carotid Microendarterectomy -- Superficial Temporal Artery to Middle Cerebral Artery Bypass Grafting -- Indirect Bypasses for Moyamoya Disease -- Subclavian Steal Syndrome -- Positional Compression of the Vertebral Arteries -- Minimally Invasive Approaches for Spontaneous Intracerebral Hemorrhage.
  • Print Material
  • A host of neurotransmitters and neuroactive substances underlies respiratory regulation in health and disease. The centerpiece of investigations regarding adaptation to hypoxia and sensorial perception has been the dopaminergic system. It is now clear that a complex interaction among various neuroactive substances, rather than a single one, forms the basis of respiratory changes. The research on neurotransmitter interactions provides the knowledge of how the brain functions and a new level of understanding of mind-to-body connection, which opens up avenues for novel therapeutic interventions.
  • Section 1. Purification of transporter proteins and cDNAs -- Section 2. Pharmacological approaches and binding studies -- Section 3. Transport assays and kinetic analyses -- Section 4. Biochemical approaches for structure-function analyses -- Section 5. Expression systems and molecular genetic approaches -- Section 6. Application of electrophysiological techniques to neurotransmitter carriers -- Section 7. Microdialysis and electrochemical measurements.
  • In this book, leading clinicians present widely accepted guidelines and evidence-based practices for the management of patients with traumatic brain injury. Divided into five main sections, the book guides the clinician through the science, management, critical care, outcomes, and important socioeconomic issues relevant to patient care. With an integrated management approach to injury and rehabilitation that goes well beyond initial surgery, Neurotrauma and Critical Care of the Brain will enable neurosurgeons, neurologists, physicians in trauma, critical care, and rehabilitation medicine, and residents in these specialties to optimize patient care and outcomes. It is also useful as a guide for board exam preparation. The companion volume to this book is Neurotrauma and Critical Care of the Spine.
  • Epidemiology of spinal injuries / Darric E. Baty ... [et al.] -- Pathophysiology of spinal injuries / Jeffrey S. Silber ... [et al.] -- Spinal cord regeneration / Charles H. Tator -- Spinal injury classification systems / F. C. Oner -- Imaging spinal cord injuries / Paul D. Campbell Jr. and John A. Carrino -- Biomechanics of the spine / Eve C. Tsai, Eric P. Roger, and Edward C. Benzel -- Prehospital management of spinal injuries / Paul Park and Kevin T. Foley -- Timing of surgery for spinal injuries / Gordon K. T. Chu and Michael G. Fehlings -- Management of cervical injuries / David O. Okonkwo, Rod J. Oskouian Jr., and Christopher I. Shaffrey -- Classification, diagnosis, and management of thoracolumbar spinal injuries / Steven C. Zeiller ... [et al.] -- Spinal cord injuries in the athlete / Brian Kwon, David H. Kim, and Alexander R. Vaccaro -- Critical care of acute spinal cord injuries / Melissa Y. Macias and Dennis J. Maimana -- Pediatric spinal injuries / William S. Anderson and George I. Jallo -- Rehabilitation and recovery from spinal injuries / Tom Stanley ... [et al.] -- Socioeconomics of spinal injuries / Rob D. Dickerman, Michael O'Malley, and Jack Zigler -- Quality of life, professionalism, and research ethics in the treatment of spinal injuries / Paul J. Ford.
  • In this review of brain trauma literature, the editors and contributors add much to accepted guidelines by providing expert opinions on questions related to resuscitation and initial assessment, brain and spinal cord injury, postacute care, sports medicine, and trauma systems. Each of the 48 questions is followed by a brief answer, boxed pearls, background, a literature review with studies classed according to strength of evidence, and conclusions and recommendations.
  • This book provides critical reviews of the role of neurotrophins and their receptors in a wide variety of diseases including neurodegenerative diseases like Huntington's syndrome, cognitive function, psychiatric disorders such as clinical depression, Rett syndrome, motoneurone disease, spinal cord injury, pain, metabolic disease and cardiovascular disease. It also contains contributions from leaders in the field dealing with the basic biology, transcriptional and post-translational regulation of the neurotrophins and their receptors. The present book will review all recent areas of progress in the study of neurotrophins and their biological roles.
  • Neurotrophin protocols
    Springer Protocols
  • This book contains articles presented at the 12th International Conference on Cerebral Vasospasm, held in Lucerne, Switzerland, in July 2013. The included papers represent a balanced cross-section of the enormous progress achieved in basic and clinical research on aneurysmal subarachnoid hemorrhage and its sequelae, including early neurovascular events and delayed cerebral vasospasm. The section on basic research covers a broad range of aspects, from pathophysiology and neuroprotection in early brain injury through to macro- and microcirculatory disturbances, inflammation and blood-brain barrier disruption, spreading depolarization, and the role of nitric oxide. There is a special focus on animal models for the study of acute events after experimental subarachnoid hemorrhage. The section on clinical topics encompasses imaging and endovascular management, surgical innovations and techniques, management and monitoring in neurocritical care, the status of clinical trials, and factors involved in aneurysm formation. This edition is of interest not only for basic researchers but also for clinicians who wish to apply state-of-the-art knowledge to the research and management of this devastating condition.
  • The use of neurovascular ultrasound is of increasing importance in neurological practice, both for radiologists and increasingly by neurologists themselves. Written by the world's most renowned expert, this book explainsultrasound examination of a stroke patient scanning protocols interpretation of the results Case examples (with a standard template presentation correlating presentation to waveform output) reinforce the book's practical nature. Illustrated with photos of the tests, explanations, and with actual waveforms, images, and resu
  • Intracranial arterial system: the main trunks and major arteries of the cerebrum -- Intracranial arterial system: basal perforating arteries -- Intracranial arterial system: infratentorial arteries -- Perforating branches of the anterior communicating artery: anatomy and infarction -- Cerebral arterial variations and anomalies diagnosed by MR angiography -- Regional MR perfusion topographic map of the brain using arterial spin labeling at 3 Tesla -- Normal anatomy of intracranial veins: demonstration with MR angiography, 3D-CT angiography and microangiographic injection study -- Mapping superficial cerebral veins on the brain surface -- Preoperative visualization of the lenticulostriate arteries associated with insulo-opercular gliomas using 3-T magnetic resonance imaging -- Ischemic complications associated with resection of opercular gliomas -- Imaging and tissue characterization of artherosclerotic carotid plaque using MR imaging -- MR imaging of cerebral aneurysms -- MR imaging of vascular malformations -- Cerebral venous malformations -- Thrombosis of the cerebral veins and dural sinuses -- Vessels of the spine and spinal cord: normal anatomy -- MDCT of the artery of Adamkiewicz -- Magnetic resonance angiography of the spinal cord blood supply -- Magnetic resonance imaging of spinal vascular lesions.
  • This volume focuses on focal and diffuse neurovascular disease in addition to systemic conditions in which cognition and behavior have been uniquely associated with different pathologic states.
  • Neurovascular surgery. 2nd edition. 2015
    Thieme eNeurosurgery
    "The complex, highly technological field of neurovascular surgery is quickly expanding, encompassing traditional surgical approaches, as well as endovascular and neurointerventional techniques. The last decade has seen increased cross-specialty interest in utilizing minimally invasive techniques to help prevent and treat cerebrovascular disease. Concurrently, there has been important research analyzing the efficacy of surgical methods versus endovascular approaches and the clip versus coil discussion is covered herein. Written by 21st Century pioneers in the field, this second, cutting-edge edition offers the latest science throughout 1,400 pages and a remarkable video library covering anatomy, diagnosis, epidemiology, history, treatment indications, technical nuances, outcomes, and complications. Internationally renowned experts from across the globe share clinical pearls and best practices, from the research lab to the ER to the OR. Medical, surgical, endovascular, cerebral revascularization, bypass surgery, radiation therapy, and other procedures are covered in depth. Evidence-based and transdisciplinary, the second edition covers the full spectrum of neurovascular pathologies, preoperatively and postoperatively, including: Ischemic Stroke and Vascular Insufficiency, Cerebral and Spinal Aneurysms, Cerebral Spinal Arteriovenous Fistulae and Malformations, Vascular Tumors, Carotid Artery Disease, Moya-Moya Disease. Organized into 11 primary sections, 99 richly illustrated chapters, and more than 140 videos, this volume is an invaluable, one-stop reference tool. It is a must-have for general, vascular and endovascular neurosurgeons; interventional radiologists; neurologists; critical care practitioners; and neuro-rehabilitation specialists"--Provided by publisher.
  • Neuroviral infections : a historical perspective -- Neuroviral infections and immunity -- Controlling neuroinflammation : lessons from rabies virus -- Laboratory diagnosis of CNS viral infections -- New trends in antiviral therapy of CNS infections -- Animal models of viral encephalitis -- Herpes simplex virus and human CNS infections -- CNS, neurological infections caused by the herpes virus Varicella zoster virus (VZV) and models of VZV-neurotropism -- Epstein- Barr virus and CNS infections -- Cytomegalovirus (CMV) infection -- Human herpesvirus 6A, 6B, and 7 encephalitis -- The human polyomavirus JC and progressive multifocal leukoencephalopathy.
  • Alphavirus neurovirulence -- Neurological chikungunya : lessons from recent epidemics, animal models, and other alphavirus family members -- Arenaviruses and neurovirology -- Bunyaviruses -- Human coronaviruses : respiratory pathogens revisited as infectious neuroinvasive, neurotropic, and neurovirulent agents -- Non-polio enteroviruses, polioviruses, and human CNS infections -- Neurovirulence of West Nile Virus -- Murray Valley encephalitis virus -- Japanese encephalitis virus and human CNS infection -- Tick Borne Encephalitis Virus (TBEV) infection -- Saint Louis encephalitis -- Powassan virus infection -- Neurological Dengue -- Influenza virus and CNS infections -- Human paramyxoviruses and infections of the central nervous system -- Rabies virus neurovirulence -- Rubella virus infections -- Human T-lymphotropic virus -- Human Immunodeficiency Virus (HIV) neuropathogenesis.
  • Neurovirology 2014
    This volume in the Handbook of Clinical Neurology series provides a complete review of the history, science and current state of neurovirology. It covers the science and clinical presentation, diagnosis, and treatment of viruses of the brain and central nervous system, and is a trusted resource for scholars, scientists, neuroscientists, neurologists, virologists, and pharmacologists working on neurovirology. Neurovirology has been significantly bolstered by modern technologies such as PCR and MRI with direct impact on isolating viruses and advancing therapeutics based on molecular medicine. These advances are particularly important today with the introduction of emerging and re-emerging diseases such as HIV/AIDS, Nipah encephalitis and the appearance of West Nile encephalitis in the western hemisphere.
  • Neutron capture therapy (NCT) is based on the ability of the non-radioactive isotope boron-10 to capture thermal neutrons with very high probability and immediately to release heavy particles with a path length of one cell diameter. This in principle allows for tumor cell-selective high-LET particle radiotherapy. NCT is exciting scientifically but challenging clinically, and a key factor in success is close collaboration among very different disciplines. This book provides a comprehensive summary of the progress made in NCT in recent years. Individual sections cover all important aspects, including neutron sources, boron chemistry, drugs for NCT, dosimetry, and radiation biology. The use of NCT in a variety of malignancies and also some non-malignant diseases is extensively discussed. NCT is clearly shown to be a promising modality at the threshold of wider clinical application. All of the chapters are written by experienced specialists in language that will be readily understood by all participating disciplines.
  • Neutrophil methods and protocols 2007
    Springer Protocols
    The role of neutrophils in the immune system: an overview / H.L. Malech -- Subcellular fractionation of human neutrophils and analysis of subcellular markers / L. Udby and N. Borregaard -- Rac and Rap GTPase activation assays / U.G. Knaus, A. Bamberg and G.M. Bokoch -- Measurement of phospholipid metabolism in intact neutrophils / S. Sergeant and L.C. McPhail -- Analysis of protein phosphorylation in human neutrophils / J. El-Benna and P.M.-C. Dang -- Mitogen-activated protein kinase assays / M. Torres -- Transduction of proteins into intact neutrophils / T. Zhao and G.M. Bokoch -- Optical methods for the measurement and manipulation of cytosolic free calcium in neutrophils / E.J. Hillson, S. Dewitt and M.B. Hallett -- Analysis of electrophysiological properties and responses of neutrophils / D. Morgan and T.E. DeCoursey -- Analysis of neutrophil apoptosis / E.L. Taylor ... [et al.] -- Optical and fluorescence detection of neutrophil integrin activation / U.Y. Schaff ... [et al.] -- Analysis of neutrophil polarization and chemotaxis / M.A. Lokuta, P.A. Nuzzi and A. Huttenlocher -- Quantifying and localizing actin-free barbed ends in neutrophils / M. Glogauer -- Measurement of neutrophil adhesion under conditions mimicking blood flow / M.A. Jutila ... [et al.] -- Model systems to investigate neutrophil adhesion and chemotaxis / N.A. Louis, E. Campbell and S.P. Colgan -- Immunofluorescence and confocal microscopy of neutrophils / L.-A.H. Allen -- Assessment of phagosome formation and maturation by fluorescence microscopy / B.E. Steinberg and S. Grinstein -- Analysis of neutrophil membrane traffic during phagocytosis / P. Loennbro, P. Nordenfelt and H. Tapper -- Analysis of neutrophil bactericidal activity / J.N. Green, C.C. Winterbourn and M.B. Hampton -- A skin chamber technique as a human model for studies of aseptic inflammatory reactions / P. Follin and C. Dahlgren -- Measurement of respiratory burst products generated by professional phagocytes / C. Dahlgren, A. Karlsson and J. Bylund -- The K-562 cell model for analysis of neutrophil NADPH oxidase function / T.L. Leto ... [et al.] -- Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask" / S. Molshanski-Mor ... [et al.] -- Immunoaffinity purification of human phagocyte flavocytochrome b and analysis of conformational dynamics / R.M. Taylor and A.J. Jesaitis -- Genome-scale transcript analyses in human neutrophils / S.D. Kobayashi, D.E. Sturdevant and F.R. DeLeo -- Fast and accurate quantitative analysis of cytokine gene expression in human neutrophils by reverse transcription real-time PCR / N. Tamassia, M.A. Cassatella and F. Bazzoni -- Detection of intact transcription factors in human neutrophils / P.P. McDonald and R.D. Ye -- Disorders of neutrophil function: an overview / M.C. Dinauer -- Diagnostic assays for chronic granulomatous disease and other neutrophil disorders / H.Z. Elloumi and S.M. Holland -- Diagnostic assays for myeloperoxidase deficiency / W.M. Nauseef.
  • Nevogenesis: Changing Theories -- Classifying Melanocytic Nevi -- Evolution of Nevi -- The Dual Pathway of Nevogenesis -- Confocal Microscopy: Improving Our Understanding of Nevogenesis -- Nevi In Children And Adults: Dermoscopic Patterns And The Development of New Nevi -- Etiology of Congenital Melanocytic Nevi And Related Conditions -- Molecular Nevogenesis -- Nevogenesis: A Benign Metastatic Process? -- Nevus Senescence -- Gene-Environment Interactions In Nevogenesis -- Malignant Transformation of Melanocytic Nevi -- Disappearance of Melanocytic Nevi.
  • Rising occurrences of various diseases and epidemics have pressurized the already-burdened health system across the globe, and this imposes an unprecedented challenge on our current research in identifying disease-specific biomarkers and molecular targets, in particular for cancers, neurological disorders and unexplained infertility. Despite decades of efforts in deciphering the fundamental biology underlying various diseases at discrete levels using an array of advanced technologies, attempts to identify reliable and disease-indicating markers for detection and biomolecules or cellular structures for targeting are still in vain. This monograph describes and discusses the updated findings in this field with a specific aim to compile prior and recent literature and from there to acquire some insights to facilitate future research to expand our options of understanding, detecting and treating diseases. Among the many possible areas of biomedical research, this content comprises two themes: disease biomarkers and molecular targets. We also cover topics that are more advanced in development to emerging scientific discoveries. In particular, we have included in this monograph concepts on the renovated use of oncofetal molecules in cancer prediction and treatment, the evolving development in cancer biology at the cellular and molecular levels and the recent involvement on new classes of molecules in diseases. We hope that this book can renew established concepts in the field, and at the same time lead to important insights for research and development of drugs, diagnostics, and interventions for managing diseases of unmet medical needs.
  • On-chip protein synthesis for making microarrays / Niroshan Ramachandran ... [et al.] -- RCA-enhanced protein detection arrays / Brian B. Haab and Paul M. Lizardi -- Antibody microarrays using resonance light-scattering particles for detection / Bernhard H. Geierstanger, Petri Saviranta, and Achim Brinker -- Chemical proteomics profiling of proteasome activity / Martijn Verdoes ... [et al.] -- Two-dimensional difference gel electrophoresis / Terence L. Wu -- Oligomeric states of proteins determined by size-exclusion chromatography coupled with light scattering, absorbance, and refractive index detectors / Ewa Folta-Stogniew -- Surface plasmon resonance imaging measurements of protein interactions with biopolymer microarrays / Terry T. Goodrich ... [et al.] -- Surface plasmon resonance mass spectrometry for protein analysis / Dobrin Nedelkov and Randall W. Nelson -- High-throughput affinity mass spectrometry / Urban A. Kiernan ... [et al.] -- Isotope-coded affinity tags for protein quantification / Christopher M. Colangelo and Kenneth R. Williams -- Proteomic analysis by multidimensional protein identification technology / Laurence Florens and Michael P. Washburn -- Isolation of glycoproteins and identification of their N-linked glycosylation sites / Hui Zhang and Ruedi Aebersold -- N-Glycosylation analysis using the StrOligo algorithm / Martin Ethier, Daniel Foigeys, and Hélène Perreault -- MALDI-MS data analysis for disease biomarker discovery / Weichuan Yu ... [et al.] -- Using the global proteome machine for protein identification / Ronald C. Beavis.
  • Theoretical considerations on animal models / Poindron, P., Callizot, N., Piguet, P. -- Mouse models with motor neuron defects as a tool for deciphering amyotrophic lateral sclerosis. Applications, limits, and future challenges / Echaniz-Laguna, A. ... [et al.] -- A chronic relapsing animal model for multiple sclerosis. Myelin oligodendrocyte glycoprotein induced experimental autoimmune encephalomyelitis in dark agouti rats / Kinter, J., Zeis, T., Schaeren-Wiemers, N. -- Occlusion of the middle cerebral artery in rats. Refinement of an animal model for human stroke / Cam, E. ... [et al.] -- Pyridoxine-induced peripheral neuropathy. Animal models and uses / Callizot, N., Poindron, P. -- A dopamine-sensitive inherited motor syndrome linked to the frissonnant mutation / Callizot, N., Guenet, J.-L., Poindron, P.
  • New antibiotic targets 2008
    Springer Protocols
  • An introduction to the generation and analysis of microbial typing data / Lenie Dijkshoorn and Kevin Towner -- Theoretical aspects of pattern analysis / Arjen van Ooyen -- Setting-up intra- and inter-laboratory databases of electrophoretic profiles / Herre F. Heersma, Kristin Kremer, Dick van Soolingen and John Hauman -- Fingerprinting of microorganisms by protein and lipopolysaccharide SDS-PAGE / Lenie Dijkshoorn -- rRNA gene restriction pattern determination (ribotyping) and computer interpretation / Patrick A.D. Grimont and Francine Grimont -- Generation and analysis of RAPD fingerprinting profiles / Kevin Towner and Hajo Grundmann -- Analysis of microbial genomic macrorestriction patterns by pulsed-field gel electrophoresis (PFGE) typing / Marc J. Struelens, Raf De Ryck and Ariane Deplano -- Selective restriction fragment amplification by AFLPTM / Paul J.D. Janssen -- Application and analysis of ARDRA patterns in bacterial identification, taxonomy and phylogeny / Mario Vaneechoutte and Marc Heyndrickx -- Insertion sequence (IS) typing and oligotyping / Nicholas A. Saunders -- Molecular characterisation of microbial communities based on 16S rRNA sequence diversity / Erwin G Zoetendal, Antoon DL Akkermans and Willem M de Vos -- From multilocus enzyme electrophoresis to multilocus sequence typing / Dominique A. Caugant.
  • This book provides an up-to-date review of recently identified natural anti-tumor compounds from various natural origins including plants, fungi, endophytic fungi and marine organisms. It also℗ℓincludes discussion of℗ℓnew areas℗ℓsuch as℗ℓbiotechnology and nanoparticles. Chapters explain the challenges and developments in anti-cancer drug discovery approaches, traditional remedies for prevention and treatment of cancer, marine-derived anti-cancer compounds, and antibiotics used as anti-cancer agents, as well as different classes of terpenoids and carbohydrates, which have℗ℓbeen the subject of discussion℗ℓin this field as efficient anti-cancer candidates. This book will be a concise guide for researchers in the field of pharmaceutical sciences, students and residents in pharmacy and medicine as well as those researching phytochemistry and natural products.
  • Chapter 1. The Need for Change: Embracing the Genome / William B. Whitman -- Chapter 2. An Introduction to Phylogenetics and the Tree of Life / Tom A. Williams, Sarah E. Heaps -- Chapter 3. The All-Species Living Tree Project / Pablo Yarza, Raul Munoz -- Chapter 4. 16S rRNA Gene-Based Identification of Bacteria and Archaea using the EzTaxon Server / Mincheol Kim, Jongsik Chun -- Chapter 5. Revolutionizing Prokaryotic Systematics Through Next-Generation Sequencing / Vartul Sangal, Leena Nieminen, Nicholas P. Tucker, Paul A. Hoskisson -- Chapter 6. Whole-Genome Analyses: Average Nucleotide Identity / David R. Arahal -- Chapter 7. Whole-Genome Sequencing for Rapid and Accurate Identification of Bacterial Transmission Pathways / Simon R. Harris, Chinyere K. Okoro -- Chapter 8. Identification of Conserved Indels that are Useful for Classification and Evolutionary Studies / Radhey S. Gupta -- Chapter 9. Reconciliation Approaches to Determining HGT, Duplications, and Losses in Gene Trees / Olga K. Kamneva, Naomi L. Ward -- Chapter 10. Multi-Locus Sequence Typing and the Gene-by-Gene Approach to Bacterial Classification and Analysis of Population Variation / Alison J. Cody, Julia S. Bennett, Martin C.J. Maiden -- Chapter 11. Multi-locus Sequence Analysis: Taking Prokaryotic Systematics to the Next Level / Xiaoying Rong, Ying Huang -- Chapter 12. Bacterial Typing and Identification By Genomic Analysis of 16S-23S rRNA Intergenic Transcribed Spacer (ITS) Sequences / Volker Gürtler, Gangavarapu Subrahmanyam, Malathi Shekar, Biswajit Maiti, Indrani Karunasagar -- Chapter 13. MALDI-TOF Mass Spectrometry Applied to Classification and Identification of Bacteria / Peter Schumann, Thomas Maier -- Chapter 14. Continuing Importance of the “Phenotype” in the Genomic Era / Peter Kämpfer -- Index.
  • The relationship between oncologists and their cancer patients is rapidly evolving. Oncologists and other cancer professionals master new anticancer and supportive treatment options, while working under increasing economic pressure and time constraints, and are often unprepared to deal with all the challenges of their new position in a therapeutic relationship with cancer patients and families. Good communication is as essential as are modern laboratory tests and sophisticated diagnostics to achieve the best clinical results. This book updates the evolution of truth-telling and communication patterns worldwide and offers insights into the recent trends and emerging challenges in communication with cancer patients and families. New Challenges in Communication with Cancer Patients is an invaluable resource to medical professionals, educators and patients in establishing a strong and effective partnership built on trust and mutual understanding.
  • Print Material
    Chapter 1. What can we learn from a family history? -- Chapter 2. How can a patient's chromosomes be studied? -- Chapter 3. How do genes work? -- Chapter 4. How can a patient's DNA be studied? -- Chapter 5. How can we check a patient's DNA for gene mutations? -- Chapter 6. What do mutations do? -- Chapter 7. What is epigenetics? -- Chapter 8. How do our genes affect our metabolism, drug responses and immune system? -- Chapter 9. How do researchers identify genes for Mendelian diseases? -- Chapter 10. Why are some conditions common and others rare? -- Chapter 11. When is screening useful? -- Chapter 12. Is cancer genetic? -- Chapter 13. Should we be testing for genetic susceptibility to common diseases? -- Chapter 14. What services are available for families with genetic disorders?
  • Print Material
    v.1. Mammary carcinoma, basal and squamous cell carcinoma, etc. -- v.2. Cardiac muscle -- v.3. New discoveries in hematology
  • Epidemiology, clinical aspects and pathology -- Epidemiology, risk factors and clinical presentation -- Pathology and genetics -- Diagnosis -- Ultrasound -- Case for MDCT -- Case for MRI -- Endoscopic ultrasonography in pancreatic tumors: when and why? -- PET/CT in pancreatic cancer -- Cost decision analysis for diagnosing and staging -- Therapy -- Case for surgery -- Locally advanced nonmetastatic cancer -- Metastatic pancreatic cancer: systemic therapy -- Role of interventional endoscopy -- Local ablative techniques in the treatment of locally advanced pancreatic cancer.
  • Print Material
  • Print Material
  • Print Material
    v. 1. Developmental considerations.--v. 2. Deviations in development.
  • Print Material
  • New drug development -- The regulatory environment -- Drug discovery -- Nonclinical research -- Designing clinical trials -- Conducting clinical trials I: Experimental methodology -- Conducting clinical trials II: Operational execution -- Statistical analysis -- Statistical significance -- Clinical significance -- Sample size estimation -- General safety assessments -- Efficacy assessment -- Cardiac and cardiovascular safety assessments -- Manufacturing small molecule drugs and biologicals -- Postmarketing surveillance -- Main themes and concluding comments -- References -- Index.
  • "Asthma, allergy and chronic obstructive lung disease are common throughout the world and are increasing in incidence, particularly in the developing world. This volume provides a state-of-the-art account of the identification of new targets and the development of new therapies for these conditions. Some 40 chapters by clinical academics and senior members of the pharmaceutical industry detail the latest breakthroughs in research and development. In asthma, a promising approach is the use of therapy directed against specific Th2 responses through biological antagonists of IL-5, IL-4 and IL-13. There have also been major advances in our understanding of innate immune responses to pathogen-associated molecular patterns, and in the area of Toll-like receptors. Up to date and comprehensive, this book will be of particular relevance to those working in the pharmaceutical industry (in preclinical research and clinical development), to academic researchers in the field of respiratory medicine, and to respiratory health care specialists."--Publisher's website.
  • The purpose of the book is to advance in the understanding of brain function by defining a general framework for representation based on category theory. The idea is to bring this mathematical formalism into the domain of neural representation of physical spaces, setting the basis for a theory of mental representation, able to relate empirical findings, uniting them into a sound theoretical corpus. The innovative approach presented in the book provides a horizon of interdisciplinary collaboration that aims to set up a common agenda that synthesizes mathematical formalization and empirical procedures in a systemic way. Category theory has been successfully applied to qualitative analysis, mainly in theoretical computer science to deal with programming language semantics. Nevertheless, the potential of category theoretic tools for quantitative analysis of networks has not been tackled so far. Statistical methods to investigate graph structure typically rely on network parameters. Category theory can be seen as an abstraction of graph theory. Thus, new categorical properties can be added into network analysis and graph theoretic constructs can be accordingly extended in more fundamental basis. By generalizing networks using category theory we can address questions and elaborate answers in a more fundamental way without waiving graph theoretic tools. The vital issue is to establish a new framework for quantitative analysis of networks using the theory of categories, in which computational neuroscientists and network theorists may tackle in more efficient ways the dynamics of brain cognitive networks. The intended audience of the book is researchers who wish to explore thevalidity of mathematical principles in the understanding of cognitive systems. All the actors in cognitive science: philosophers, engineers, neurobiologists, cognitive psychologists, computer scientists etc. are akin to discover along its pages new unforeseen connections through the development of concepts and formal theories described in the book. Practitioners of both pure and applied mathematics e.g., network theorists, will be delighted with the mapping of abstract mathematical concepts in the terra incognita of cognition.
  • New foundation of biology 2001
  • Traditionally, neuroscience has considered the nervous system as an isolated entity and largely ignored influences of the social environments in which humans and many animal species live. However, there is mounting evidence that the social environment affects behavior across species, from microbes to humans. This book brings together scholars who work with animal and human models of social behavior to discuss the challenges and opportunities in this interdisciplinary academic field.
  • Methods and tools in molecular epidemiology -- Molecular typing of bacterial pathogens: a tool for the epidemiological study and control of infectious diseases -- Contribution of population genetics -- Molecular epidemiology and evolutionary genetics of infectious diseases -- Population genetics and molecular epidemiology of infectious diseases -- Contribution of population and evolutionary epidemiology -- Modelling the dynamics of host-parasite interactions: basic principles -- Evolution of virulence: intuitions and models -- Case studies -- Molecular epidemiology of tuberculosis -- Pneumocystis molecular phylogeny: a way to understand both pneumocystosis natural histry and host taxonomy -- Hantavirus genetic diversity -- New integrations -- Nasal carriage of methicillin-resistant coagulase-negative staphylocococci: a reservoir of mecA gene for Staphylococcus aureus -- Molecular knowledge of mechanisms of helminth resistance: importance for diagnostic and epidemiology -- Molecular epidemiology of disease resistance genes with perspectives for researches on biological invasions and hybrid zones -- How does biodiversity influence the ecology of infectious disease? -- Epidemiological interaction at the wildlife/livestock/human interface: can we anticipate emerging infectious diseases in their hotspots? A framework for understanding emerging diseases processes in their hot spots.
  • Gene Expression Profiling and Regulatory Networks in Single Cells / Fumio Arai, Kentaro Hosokawa, Yoshiko Matsumoto, Hirofumi Toyama and Toshio Suda -- Cell Fate Regulatory Networks / Sonya J. Ridden and Ben D. MacArthur -- Noise in Regulatory Networks / Srinandan Dasmahapatra -- Generalised Modelling in Systems Biology / Thilo Gross -- Relative Quantification Mass Spectrometry Using iTRAQ Isobaric Tags / Richard D. Unwin, Emma Carrick and Anthony D. Whetton -- Deciphering Protein Complexes and Protein Interaction Networks for Stem Cell Pluripotency / Jianlong Wang -- Omics Era in Stem Cell Research: Data Integration of Multi-regulatory Layers / Ana Sevilla, Benjamin Trinite and Ihor R. Lemischka -- High Throughput Affinity Purification and Mass Spectrometry to Determine Protein Complex Interactions / Anna Malovannaya, Rainer B. Lanz, Bert W. O'Malley and Jun Qin -- Network Pharmacology to Aid the Drug Discovery Process / Ruth Dannenfelser, Huilei Xu, Catherine Raimond and Avi Ma'ayan -- What Can Networks Do for You? / Bernhard M. Schuldt, Franz-Josef Müller and Andreas A. Schuppert.
  • Overview: developments in DNA sequencing / Keith R. Mitchelson ... [et al.] -- Chip capillary electrophoresis and total genetic analysis systems / Quiang Xiong and Jing Cheng -- Comparative sequence analysis by MALDI-TOF mass spectrometry: utilizing the known to discover the new / Mathias Ehrich, Franz Hillenkamp, and Dirk van den Boom -- Advances in dye-nucleotide conjugate chemistry for DNA sequencing / Shiv Kumar and Carl W. Fuller -- The 454 life sciences picoliter sequencing system / Marcel Margulies ... [et al.] -- An integrated system for DNA sequencing by synthesis / John R. Edwards, Dae Hyun Kim, and Jingyue Ju -- Single-molecule fluorescence microscopy and its applications to single-molecule sequencing by cyclic synthesis / Benedict Hebert and Ido Braslavsky -- Rapid DNA sequencing by direct nanoscale reading of nucleotide bases on individual DNA chains / James Weifu Lee and Amit Meller -- A single molecule system for whole genome analysis / Shiguo Zhou, Jill Herschleb, and David C. Schwartz -- Sequencing aided by mutagenesis facilitates the de novo sequencing of megabase DNA fragments by short read lengths / Jonathan M. Keith ... [et al.] -- Genome sequencing and assembly / Annette McGrath -- Valid recovery of nucleic acid sequence information from high contamination risk samples: ancient DNA and environmental DNA / George A. Kowalchuk ... [et al.].
  • Immunity to fungi -- In vitro models to analyse fungal infection -- Insects as models for studying the virulence of fungal pathogens of humans -- Novel antifungal therapies -- Candida albicans: new insights in infection, disease, and treatment -- Pathogenesis of Cryptococcus neoformans -- Zygomycetes -- Virulence of Aspergillus fumigatus -- Biology of the thermally dimorphic fungal pathogen Penicillium marneffei -- Immune responses to dermatophytoses -- Insights in Paracoccidioides brasiliensis pathogenicity -- Fusarium and Scedosporium: emerging fungal pathogens.
  • Chronic kidney disease is a global major health issue that ultimately leads to end-stage renal disease, a devastating condition requiring costly renal replacement therapy. Given this background, extensive understanding of the pathogenesis of the disease and exploring novel therapeutic targets will help to alleviate disease progression, improve prognosis and reduce its impact on the global economic burden.Currently, primary glomerulonephritis is the leading cause of chronic kidney disease and end-stage renal disease in China and many other countries. Recently, there has been much progress with regard to pathogenesis as well as treatment of primary glomerulonephritis. Clinical data from Chinese studies have significantly contributed to the making of international guidelines and histological classifications of the disease. This book focuses on the cutting-edge knowledge and provides up-to-date information on primary glomerulonephritis. Topics covered are IgA nephropathy, focal segmental glomerulosclerosis, membranous nephropathy, membranoproliferative glomerulonephritis, and crescentic glomerulonephritis.
  • Hippocampal slice cultures / Förster, E., Bartos, M., Zhao, S. -- Protocol for the primary culture of cortical neurons / Gonthier, B. ... [et al.] -- A new technique to control the architecture of neuronal networks in vitro / Wyart, C. ... [et al.] -- Organotypic cultures of the rat retina / Hofmann, H.-D. ... [et al.] -- Cerebellar slice cultures / Kapfhammer, J.P. -- Culture of dissociated hippocampal neurons / Rigato, F. -- Improved methods for culturing rat and mouse motor neurons. Their applications / Guettier-Sigrist, S. ... [et al.] -- Characterization of long-term cultured cell lines of murine microglia called MAMI. The case for MAMI-96 cell line / Laporte, V. ... [et al.].
  • New oral anticoagulants / Jawed Fareed -- Venous thromboembolism (post-surgery) / Erica Romualdi & Walter Ageno -- New oral anticoagulants for stroke prevention in atrial fibrillation / Sarkis Morales-Vidal, Michael J. Schneck, Murray Flaster & Jose Biller -- Acute coronary syndromes / Paul A. Gurbel & Udaya S. Tantry -- Current VTE prophylaxis and new oral anticoagulants for acute medical in-patients / Evi Kalodiki & Christopher R. Lattimer -- New antithrombotic agents in cancer patients / Grigoris T. Gerotziafas, Michel Meyer Samama & Ismail Elalamy -- New oral anticoagulants for autoimmune diseases / Debra Hoppensteadt, Jeanine M. Walenga & Mamdouh Bakhos -- New oral anticoagulants for special populations / Jeanine M. Walenga & Mamdouh Bakhos -- Will warfarin become obsolete? / Jawed Fareed, Wendy A. Leong & Joseph A. Caprini -- Index.
  • Overview -- Magnesium homeostasis -- Nutrition -- Epidemiology -- Exercise -- Metabolic syndrome -- Cardiovascular disease -- Skeletal diseases and calcium metabolism -- Kidney -- Neurology -- Magnesium in dental medicine -- Magnesium in neurology and psychiatry -- Veterinary medicine.
  • Mechanisms of Vessel Regression: Toward an Understanding of the Resolution of Angiogenesis / Mateusz S. Wietecha, Wendy L. Cerny, Luisa A. DiPietro -- Wound Healing in Mammals and Amphibians: Toward Limb Regeneration in Mammals / Aiko Kawasumi, Natsume Sagawa, Shinichi Hayashi -- Cellular Plasticity During Vertebrate Appendage Regeneration / James R. Monaghan, Malcolm Maden -- Cell Signaling Pathways in Vertebrate Lens Regeneration / Jonathan J. Henry, Alvin G. Thomas, Paul W. Hamilton -- Regenerative Medicine: Challenges and Perspectives for Successful Therapies / S. Viswanathan, C. Joshi -- Employing the Biology of Successful Fracture Repair to Heal Critical Size Bone Defects / Jo Ann Cameron, Derek J. Milner, Jung Seok Lee -- Muscle Repair and Regeneration: Stem Cells, Scaffolds, and the Contributions of Skeletal Muscle to Amphibian Limb Regeneration / Derek J. Milner, Jo Ann Cameron -- Neural Regeneration / Melissa M. Steward, Akshayalakshmi Sridhar -- Teleost Fish as a Model System to Study Successful Regeneration of the Central Nervous System / Günther K. H. Zupanc, Ruxandra F. Sîrbulescu -- Epigenetics and Regeneration / Nobuyasu Maki, Hironobu Kimura -- Cell Cycle Regulation and Regeneration / Ellen Heber-Katz, Yong Zhang, Khamila Bedelbaeva.
  • Overview of the Mesoamerican primate fauna, primate studies, and conservation concerns / Alejandro Estrada ... [et al.] -- Taxonomy and distributions of Mesoamerican primates / Anthony B. Rylands ... [et al.] -- The biogeographic history of Mesoamerican primates / Susan M. Ford -- Demographic features of Alouatta pigra populations in extensive and fragmented forests / Sarie Van Belle and Alejandro Estrada -- Population structure of black howlers (Alouatta pigra) in southern Belize and responses to Hurricane Iris / Mary S.M. Pavelka and Colin A. Chapman -- The effects of forest fragment age, isolation, size, habitat type, and water availability on monkey density in a tropical dry forest / Holly Noelle DeGama-Blanchet and Linda Marie Fedigan -- Forest fragmentation and its effects on the feeding ecology of black howlers (Alouatta pigra) from the Calakmul area in Mexico / Andrómeda Rivera and Sophie Calmé -- Intestinal parasitic infections in Alouatta pigra in tropical rainforest in Lacandona, Chiapas, Mexico : implications for behavioral ecology and conservation / Kathryn E. Stoner and Ana González Di Pierro -- Average body weight for mantled howling monkeys (Alouatta palliata) : an assessment of average values and variability / Kenneth E. Glander -- An exploratory analysis of developmental plasticity in Costa Rican mantled howler monkeys (Alouatta palliata palliata) / Clara B. Jones -- Travel patterns and spatial mapping in Nicaraguan mantled howler monkeys (Alouatta palliata) / Paul A. Garber and Petra E. Jelinek -- Use of landmark cues to locate feeding sites in wild capuchin monkeys (Cebus capucinus) : an experimental field study / Paul A. Garber and Ellen Brown -- Leap, bridge, or ride? Ontogenetic influences on positional behavior in Cebus and Alouatta / Michelle F. Bezanson -- Food choice by juvenile capuchin monkeys (Cebus capucinus) in a tropical dry forest / Katherine C. MacKinnon -- Why be alpha male? Dominance and reproductive success in wild white-faced capuchins (Cebus capucinus) / Katharine M. Jack and Linda M. Fedigan -- Post-conceptive mating in white-faced capuchins, Cebus capucinus : hormonal and sociosexual patterns of cycling, noncycling, and pregnant females / Sarah D. Carnegie, Linda M. Fedigan and Toni E. Ziegler -- Growth of a reintroduced spider monkey (Ateles geoffroyi) population on Barro Colorado Island, Panama / Katharine Milton and Mariah E. Hopkins -- Primates in agroecosystems : conservation value of some agricultural practices in Mesoamerican landscapes / Alejandro Estrada ... [et al.] -- Primate populations in the protected forests of Maya archaeological sites in southern Mexico and Guatemala / Alejandro Estrada ... [et al.] -- Mapping primate populations in the Yucatan Peninsula, Mexico : a first assessment / Juan Carlos Serio-Silva, Víctor Rico-Gray and Gabriel Ramos-Fernández -- A metapopulation approach to conserving the howler monkey in a highly fragmented landscape in Los Tuxtlas, Mexico / Salvador Mandujano ... [et al.] -- Quantifying fragmentation of black howler (Alouatta pigra) habitat after Hurricane Iris (2001), southern Belize / Shelley M. Alexander, Mary S.M. Pavelka and Nicola H. Bywater -- New perspectives in the study of Mesoamerican primates : concluding comments and conservation priorities / Paul A. Garber, Alejandro Estrada and Mary S.M. Pavelka.
  • Foreword / Milton I. Roemer -- A history of public health -- Expanding the concept of public health -- Measuring and evaluating the health of a population -- Communicable diseases -- Noncommunicable conditions -- Family health -- Special community health needs -- Nutrition and food safety -- Environmental and occupational health -- Organization of public health systems -- Measuring costs: the economics of health -- Planning and managing health systems -- National health systems -- Human resources for health care -- Technology, quality, law and ethics -- Globalization of health -- Glossary -- Subject index.
  • Socio-demographic societal and supra-societal determinants and influences -- Social determinants of sexual networks, partnership formation, and sexually transmitted infections -- Epidemiology of STI and HIV: an overview of concentration and geographical and temporal dispersion -- Migration and the transmission of STIs -- Sexual networks and sexually transmitted infections: the strength of weak (long distance) ties -- Personal risk and public impact: balancing individual rights with STD and HIV prevention -- Critical factors in approaches to prevention -- Distribution of prevention resources and impact of sexual health in the USA -- Scaling up, coverage, and targeting -- Electronic media and STI prevention -- Twenty-first century leadership for public health and HIV/STI prevention -- Critical reveiws: enw public health focus for populations at risk for STI/HIV -- Enhancing women's sexual health: prevention measures in diverse populations of women -- Prevention of HIV and other blood-borne and sexually transmitted diseases in people who inject drugs: current status and future prospects -- Health, seuxal health, and syndemicsL toward a better appraoch to STI and HIV preventive interventions for men who have sex with men (MSM) in the United States -- Social determinants of sexual health in the USA among racial and ethnic minorities -- Adolescent sexual health and sexually transmitted infections: a conceptual and empirical demonstration -- Critical reviews: new public health STD/HIV prevention -- Preventing HIV/AIDS in the United States, 1981-2009: history in the making -- National strategic approach to improving the health of gay and bisexual men: experience in Australia -- Reducing disparities in sexual health: lessons learned from the campaign to eliminate infectious syphilis from the United States -- Human papillomavirus vaccine and prevention of human papillomavirus-associated disease in the USA -- Chlamydia control: a comparative reveiw from the USA and UK.
  • Print Material
    The transformation of pharmacogenetics into pharmacogenomics reinforces personalized medicine towards pharmacotyping for improved patient care / Ioannis S. Vizirianakis -- Development, analysis and use of pharmacogenomic time series for pharmacokinetic/pharmacodynamic modeling of multi-tissue polygenic responses to corticosteroids / Richard R. Almon ... [et al.] -- Clinical applications of pharmacogenetics: genetic polymorphisms and neuroleptic malignant syndrome / Chiaki Kawanishi -- Genetic detection of antimicrobial resistance determinants in gram-positive cocci / Toshinobu Horii -- A special bibliography.
  • The changing population: the surgeon's challenge -- Fundamentals of the past: cardioplegia: the first period revisited -- Sites of injury: myocyte -- Sites of injury: the endothelium -- Intraoperative protection of the myocardium: effects of age and gender -- Protection of the right heart -- Protection of the failing heart -- Protection during heart transplantation -- The endothelium as target for interventions -- Vascular effects of cardioplegic arrest and cardiopulmonary bypass -- Oxygen radical scavengers -- New approaches to cardioplegia: alternatives to hyperkalemia -- Myocardial protection via the coronary venous route -- Donor heart preservation by continuous perfusion -- Visualization of cardioplegia delivery.
  • Global figures argue in favour of preventive measures and personalised treatment to optimise inadequate diabetes care -- Three levels of prediction, prevention and individualised treatment algorithms to advance diabetes care: integrative approach -- Diabetes Mellitus: new challenges and innovative therapies -- Identification of biomarkers for beta cell failure as detection tools for predictive screening in Type 2 pre-diabetes -- Endothelial dysfunction in diabetes: role of circulating biomarkers as potential diagnostic and prognostic tools -- Correction of diabetes-induced endothelial progenitor dysfunction to promote retinal vascular repair -- Oxidative stress and apoptotic biomarkers in diabetic retinopathy -- Diabetic retinopathy: the need for predictive, preventive and personalized approach to management -- The rle of inflammatory cytokines in diabetic nephropathy: potential use as predictive markers for early detection and progression -- Preventing hyperglycemia and tissue injury in diabetes: the dynamic role of 2, 3 indoleaminedioxygenase (IDO) in diabetes and its complications -- An integrative approach to chronic wounds in patients with diabetes: PPPM in action -- Understanding inflammation: the key to targeted preventive measures for diabetes and periodontitis -- Cancer predisposition in diabetic patients: risk assessment and targeted preventive measures -- Recognition of individual risks by analysis of subcellular imaging insights into chromium picolinate therapy in pre/diabetes care, search into its safety and opinion controversy -- Remote control in diabetes -- Drug delivery systems for predictive medicine: polymers as tools for advanced applications.
  • New taxonomy 2008
    Introductory : toward the new taxonomy / Quentin D. Wheeler -- Networks and their role in e-taxonomy / Malcolm J. Scoble -- Taxonomy as a team sport / Sandra Knapp -- Planetary biodiversity inventories as models for the new taxonomy / Lawrence M. Page -- On the use of taxonomic concepts in support of biodiversity research and taxonomy / Nico M. Franz, Robert K. Peet and Alan S. Weakley -- International infrastructure for enabling the new taxonomy : the role of the Global Biodiversity Information Facility (GBIF) / Larry Speers and James L. Edwards -- DNA sequence in taxonomy : opportunities and challenges / Rudolf Meier -- Animal names for all : ICZN, ZooBank and the new taxonomy / Andrew Polaszek, Richard Pyle and Doug Yanega -- Understanding morphology in systematic contezxt : three-dimensional specimen ordination and recognition / Norman MacLeod -- Taxonomic shock and awe / Quentin D. Wheeler.
  • New Techniques for Thoracic Outlet Syndromes presents in a comprehensive format an up-to-date, state of the art reference that physicians can use in consultation to properly treat patients using the resources that modern medicine offers. This book offers the newer surgical approaches that have been developed during the past 30 years. Some of these techniques are modification of operations that were proposed previously but were not fully affective and left many patients suffering with permanent disability. This textbook is a compendium of the proper management of these patients that cannot be found in isolated reports of literature. The neurogenic-arterial thoracic outlet syndrome section covers how to diagnosis the illness using the proper tests, therefore eliminating the use of expensive, uncomfortable and inconvenient tests. The text is organized in three basic sections that cover all the aspects of the thoracic outlet syndromes. The first section addresses the neurogenic-arterial type, with the pertinent subsections: symptoms, diagnosis. A list of the useful tests is provided to make a correct diagnosis of this syndrome. This is followed by the sections on treatment, using the surgical approaches with historical aspects and evolution of the operations proposed. The second section involves the venous thoracic outlet syndrome divided into the corresponding subsections comprising: symptoms and physical findings, etiology, diagnosis. This section also includes a list of the usual tests to make the proper diagnosis. The last section of this text is dedicated to the presence of cervical ribs and their classification of the different types that occur, and also the proper surgical treatment when fusion of the upper ribs is present. New Techniques for Thoracic Outlet Syndromes offers the current, acceptable and most effective methods to handle thoracic outlet syndromes. It will be of great value to thoracic surgeons, vascular surgeons, interventional radiologists as well as fellows and residents in training for cardiothoracic and vascular surgery.
  • Print Material
  • This book provides an up-to-date review of current management techniques for Non-Small Cell Lung Cancer. It addresses all of the latest issues that have been raised by the discovery of oncogenic drivers and the improvement of diagnosis and therapeutic methods, including new radiotherapy techniques and anticancer strategies like immunotherapy. New strategies for patients with molecular alterations and the management of particular types of cases are also highlighted. Written by recognized experts in their field, the book represents a unique and valuable resource in the field of lung cancer, both for those currently in training and for those already in clinical or research practice.
  • Transcription factor genes in type 2 diabetes / by M.N. Weedon, A.T. Hattersley & T.M. Frayling -- PPAR[gamma], a key therapeutic target in the metabolic syndrome-unique insights derived from the study of human genetic variants / by C.S. Mitchell & M. Gurnell -- PPAR[delta]: emerging therapeutic potential of novel agonists in lipid and glucose homeostasis / by U. Dressel & G.E.O. Muscat -- Liver X receptors as potential drug targets for diabetes and its disorders / by K.R. Steffenson -- SREBP-lc regulation of nutrient homeostasis and lipid accumulation / by P. Ferré ... [et al.] -- The adipocyte and adipose tissue as endocrine organs: impact on the insulin resistance phenotype / by R.R. Henry ... [et al.] -- FOXC2 in the adipocyte / by S. Enerbäck -- Regulation of adipocyte differentiation and metabolism by Wnt signaling and C/EBP transcription factors / by I. Gerin, H.D. Cha & O.A. MacDougald -- GATA proteins as molecular gatekeepers of adipogenesis / by J. Tsai, Q. Tong & G.S. Hotamisligil -- Forkhead proteins and the regulation of hepatic gene expression / by A. Barthel, S. Herzig & D. Schmoll -- Disruption of CREB regulated of gene expression in diabetes / by J.E.B. Reusch, P.A. Watson & S. Pugazhenthi -- Regulation of PGC-1 in humans with insulin resistance and type 2 diabetes: functional implications / by J. Pihlajamäki & M.E. Patti -- Hepatic CCAAT/enhancer binding protein [beta] (C/EBP[beta]): engineer of diabetes, obesity, and inflammatory disease processes / by J.M. Schroeder-Gloeckler, S.M. Rahman & J.E. Friedman -- Insulin resistance, inflammation, and the IKK/I[kappa]B/NF-[kappa]B pathway by B.A. Bhatt & R.M. O'Doherty.
  • The philosophy of treatment of uveitis : past, present and future / Kruh, J., Foster, C.S. -- The gold standard of noninfectious uveitis : corticosteroids / Lehoang, P. -- Corticosteroid-sparing agents : conventional systemic immunosuppressants / Kruh, J., Foster, C.S. -- Corticosteroid-sparing agents : new treatment options / Tomkins-Netzer, O., Taylor, S.R.J., Lightman, S. -- Mycophenolate mofetil use in the treatment of noninfectious uveitis / Klisovic, D.D. -- Anti-tumor necrosis factor : agents in noninfectious uveitis / Gueudry, J., LeHoang, P., Bodaghi, B. -- New biologic drugs : anti-interleukin therapy -- Tappeiner, C. ... [et al.] -- Interferon / Deuter, C., Stübiger, N., Zierhut, M. -- Rituximab for the treatment of noninfectious uveitis / Miserocchi, E., Modorati, G. -- Intravitreal injection therapy in the treatment of noninfectious uveitis / Modorati, G., Miserocchi, E. -- Corticosteroid intravitreal implants / de Smet, M.D. -- New treatment options for noninfectious uveitis / Gomes Bittencourt, M. ... [et al.].
  • Allergy in evolution / Platts-Mills, T.A.E. -- Climate change, environment and allergy / Behrendt, H., Ring, J. -- The hygiene hypothesis does not apply to atopic eczema in childhood / Cramer, C. ... [et al.] -- Molecular genetics of atopic eczema / Ring, J., Mohrenschlager, M., Weidinger, S. -- Mechanisms of immune tolerance to allergens / Fujita, H. ... [et al.] -- TH17 and TH22 in skin allergy / Cavani, A., Pennino, D., Eyerich, K. -- IL-25 induces both inflammation and skin barrier dysfunction in atopic dermatitis / Deleuran, M. ... [et al.] -- Angiogenesis, lymphangiogenesis and atopic dermatitis / Genovese, A. ... [et al.] -- What can dogs bring to atopic dermatitis research? / Olivry, T. -- Can microbial superantigens influence atopic dermatitis flares? / Alomar, A. -- Inflammation-induced alterations in the skin barrier function: implications in atopic dermatitis / Vestergaard, C. ... [et al.] -- Itch and eczema / Darsow, U. -- Eczema herpeticum / Wollenberg, A. -- Bone mineral density in patients with atopic dermatitis / Haeck, I. -- Immunosuppressive effect of prolactin-induced protein / Sugiura, S. ... [et al.] -- Is food allergy testing reliable in pediatric atopic dermatitis? A population-based study / Keck, L.E. ... [et al.] -- New strategies for dealing with staphylococcus aureus colonization and the emerging methicillin-resistant staphylococcus aureus epidemic in atopic dermatitis / Boguniewicz, M. -- Anti-IL-4 as a new strategy in allergy / Schmidt-Weber, C.B. -- New drug targets in atopic dermatitis / Simon, D., Simon, H.U. -- Latest approaches to treating atopic dermatitis / Paller, A.S.
  • v. 221 ScienceDirect
    New Trends in Basic and Clinical Research of Glaucoma: A Neurodegenerative Disease of the Visual System is the latest volume from Progress in Brain Research focusing on new trends in basic and clinical research of glaucoma. This established international series examines major areas of basic and clinical research within neuroscience, as well as emerging subfields.
  • Prognostic and therapeutic targets in the Ewing's family of tumors (PROTHETS) / P. Picci ... [et al.] -- Targeted therapies in Ewing's sarcoma / K. Scotlandi -- The CCN3 protein and cancer / B. Perbal -- EWS-FLI1 in Ewing's sarcoma: real targets and collateral damage / J. Ban ... [et al.] -- Molecular karyotyping in sarcoma diagnostics and research / H. Vauhkonen ... [et al] -- TuBaFrost: European virtual tumor tissue banking / P.H.J. Riegman ... [et al] -- Virtual microscopy in virtual tumor banking / M. Isabelle ... [et al] -- Harmonizing cancer control in Europe / U. Ringborg -- The diagnosis of cancer: from H&E to molecular diagnosis and back / J. Costa -- From morphological to molecular diagnosis of soft tissue tumors / M. Miettinen -- Prediction of response to neoadjuvant chemotherapy in carcinomas of the upper gastrointestinal tract / H. Höfler ... [et al] -- Integrating the diagnosis of childhood malignancies / D. López-Terrada -- Preclinical models for cell cycle-targeted therapies / M. Malumbres -- WWOX, a chromosomal fragile site gene and its role in cancer / D. Ramos and C.M. Aldaz -- From genome to proteome in tumor profiling: molecular events in colorectal cancer genesis / J.K. Habermann ... [et al] -- Effect of hypoxia on the tumor phenotype: the neuroblastoma and breast cancer models / L. Holmquist, T. Löfstedt, and S. Påhlman -- Methylation patterns and chemosensitivity in NSCLC / J.L. Ramírez ... [et al] -- Pharmacogenomics and colorectal cancer / H.J. Lenz -- Development of pharmacogenomic predictors for preoperative chemotherapy of breast cancer / L. Pusztai -- Vascular endothelial growth factor inhibitors in colon cancer / E. Díaz-Rubio -- Molecular imaging of cancer using PET and SPECT / A. Kjær -- MRS as endogenous molecular imaging for brain and prostate tumors: FP6 project "eTUMOR" / B. Celda ... [et al] -- From Linac to tomotherapy: new possibilities for cure? / G. Storme ... [et al] -- Targeting mTOR for cancer treatment / B. Rubio-Viqueira and M. Hidalgo -- Dual/pan-her tyrosine kinase inhibitors: focus in breast cancer / J. Albanell -- Antitumor-associated antigens IGGS: dual positive and negative potential effects for cancer therapy / E. Barberá Guillem and J.W. Sampsel -- Synergistic molecular mechanisms in hormone-sensitive breast cancer / A. Llombart Cussac.
  • Intracranial aneuryms -- Perioperative management -- Management of unruptured intracranial aneurysms -- Intracranial arteriovenous malformations and Rural AVM, AVF -- Cerebral revascularization -- Venous system.
  • pt. 1. Introduction and overview -- pt. 2. The four pieces that make up the unified theory -- pt. 3. Solving the problem of psychology -- pt. 4. Conclusion.
  • Print Material
  • 2012 ClinicalKey
    Molecular bases for lung development, injury, and repair / Shu Wu -- Genetic influences in lung development and injury / Vineet Bhandari -- Perinatal events and their influence on lung development and function / Alan H. Jobe, Suhas G. Kallapur, Boris W. Kramer -- Hypoxia and hyperoxia : effects on the newborn pulmonary circulation / Stephen Wedgwood, Paul T. Schumacker, Robin Steinhorn -- The role of nitric oxide in lung growth and function / Girija G. Konduri -- Prenatal and postnatal microbial colonization and respiratory outcome in preterm infants / Rose M. Viscardi -- Influence of nutritional neonatal respiratory outcome / Cristina Navarrete, Ilene R.S. Sosenko -- Patent ductus arteriosus and the lung : acute effects and long-term consequences / Eduardo Bancalari, Ilene R.S. Sosenko, Nelson Claure -- Role of stem cells in neonatal lung injury / Karen C. Young, Cleide Suguihara -- New developments in the pathogenesis and prevention of bronchopulmonary dysplasia / Ilene R.S. Sosenko, Eduardo Bancalari -- Long-term pulmonary outcome of preterm infants / Lex W. Doyle -- Respiratory and cardiovascular support in the delivery room / Myra H. Wyckoff -- Noninvasive respiratory support : an alternative to mechanical ventilation in preterm infants / Peter Davis, Colin J. Morley, Brett J. Manley -- Surfactant replacement : present and future / Christian P. Speer, David Sweet -- Oxygenation targeting and outcomes in preterm infants : the new evidence / Win Tin, Waldemar A. Carlo, Samir Gupta -- Hypoxemic episodes in the premature infant : causes, consequences, and management / Nelson Claure, Eduardo Bancalari -- Patient ventilator interaction / Eduardo Bancalari, Nelson Claure -- Strategies for limiting the duration of mechanical ventilation / Eduardo Bancalari, Nelson Claure -- Automation of respiratory support / Nelson Claure, Eduardo Bancalari -- Management of the infant with congenital diaphragmatic hernia / Roberta L. Keller -- Management of the infant with severe bronchopulmonary dysplasia / Steven Abman, Leif D. Nelin.
  • Print Material
  • Preface -- Next generation sequencing methodologies -- Emergence of next generation sequencing -- Assembly of sequencing data -- De novo assembly algorithms -- Index.
  • Introduction: next generation sequencing technology and cancer research -- The majority of total nuclear-encoded non-ribosomal RNA in a human cell is dark matter unannotated RNA -- Total RNA-seq of breast cancer in hypoxia -- Altered antisense-to-sense transcript ratios in breast cancer -- Identification of piRNAs in Hela cells by massive parallel sequencing -- Discovery of new microRNAs by small RNAome deep sequencing in childhood acute lymphoblastic leukemia -- Whole-Exome Sequencing Identifies FAM20A Mutations as a Cause of Amelogenesis Imperfecta and Gingival Hyperplasia Syndrome -- Whole-exome sequencing in CIC and IDH1/2 contributing to human oligodendroglioma -- Genetic and structural variation in the gastric cancer kinome revealed through targeted deep sequencing -- Tumour evolution inferred by single-cell sequencing -- Characterization of the single-cell transcriptional landscape by highly multiplex RNA-seq -- Tracing the derivation of embryonic stem cells from the inner cell mass by single-cell RNASeq analysis -- Whole genome DNA methylation analysis based on high throughput sequencing technology -- Comparative methylome analysis of benign and malignant peripheral nerve sheath tumors -- High-resolution genome-wide mapping of HIF-binding sites by ChIP-seq -- MicroRNA transfection and AGO-bound CLIP-seq data sets reveal distinct determinants of miRNA action -- Genome-wide identification of polycomb-associated RNAs by RIP-seq -- Single-molecule sequencing: sequence methods to enable accurate quantisation -- Metabolic labeling of RNA uncovers principles of RNA production and degradation dynamics in mammalian cells -- Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA -- The genome information process for cancer research: the challenge and perspective.
  • This book introduces readers to Next Generation Sequencing applications in medical genetics. The authors discuss the direct application of next-generation sequencing to medicine, specifically, laboratory medicine or molecular diagnostics. The first part of the book contains chapters on sanger sequencing, NGS technologies, targeted-amplification and capture, and exome sequencing. The second part of the book focuses on genetic disorders diagnoses by NGS, prenatal diagnosis, muscular dystrophies, mitochondrial disorders diagnosis, and challenges in molecular diagnosis. Recent developments and potential future trends in NGS sequencing applications are highlighted, as well.
  • Overview. History of DNA Sequencing Technologies / Lisa D. White -- Clinical Molecular Diagnostic Techniques: A Brief Review / Megan L. Landsverk, Lee-Jun C. Wong -- The Technologies and Bioinformatics. Methods of Gene Enrichment and Massively Parallel Sequencing Technologies / Hong Cui -- Sequence Alignment, Analysis, and Bioinformatic Pipelines / Fuli Yu, Cristian Coarfa -- Protein Structural Based Analysis for Interpretation of Missense Variants at the Genomics Era: Using MNGIE Disease as an Example / Victor Wei Zhang -- Algorithms and Guidelines for Interpretation of DNA Variants / Jing Wang, Megan Landsverk -- Application to Clinical Diagnosis. NGS-Based Clinical Diagnosis of Genetically Heterogeneous Disorders / C. A. Valencia, T. A. Sivakumaran, B. T. Tinkle -- Molecular Diagnosis of Congenital Disorders of Glycosylation (CDG) / Melanie Jones, Madhuri Hegde -- NGS Improves the Diagnosis of X-Linked Intellectual Disability (XLID) / Michael J. Friez, Monica J. Basehore -- NGS Analysis of Heterogeneous Retinitis Pigmentosa / Rui Chen, Feng Wang -- Next-Generation Sequencing Analyses of the Whole Mitochondrial Genome / Lee-Jun C. Wong -- Application of Next-Generation Sequencing of Nuclear Genes for Mitochondrial Disorders / Valeria Vasta, Si Houn Hahn -- Noninvasive Prenatal Diagnosis Using Next-Generation Sequencing / Nancy Bo Yin Tsui, Yuk Ming Dennis Lo -- Compliance with CAP/CLIA Regulations. Guidelines and Approaches to Compliance with Regulatory and Clinical Standards: Quality Control Procedures and Quality Assurance / Ira M. Lubin, Lisa Kalman, Amy S. Gargis -- Validation of NGS-Based DNA Testing and Implementation of Quality Control Procedures / Victor Wei Zhang, Lee-Jun C. Wong -- Frequently Asked Questions About the Clinical Utility of Next-Generation Sequencing in Molecular Diagnosis of Human Genetic Diseases / Ephrem L. H. Chin, Victor Wei Zhang, Jing Wang, Margherita Milone, Susan Pacheco.
  • Print Material
    Medicine's mission -- Symptoms -- Medicine's historical foundations -- The practice of medicine and the rise of the technological imperative -- Diagnosing current medicine -- Current medicine's treatment : next medicine -- The science of health -- Unweaving health -- Tons to ounces : repair to prevention -- Healthier living and aging : mens sana in corpore sano -- Closing the loop : healthy death -- Framing next medicine -- Next medicine in situ : healthier communities.
  • Print Material
    Part I. Endoscopy as a Philosophy: Ancient-European Scientific Revolution (1700s) -- Part II. The Beginning of Early Modern Endoscopy 1800-1877: Bozzini, Desormeaux, Cruise -- Part III. 1870s-1899: The Era of Nitze -- Part IV. Early 20th Century: 1900-1939 -- Part V. 1940s-Present.
  • Print Material
  • Understanding the logic of I[kappa]B:NF-[kappa]B regulation in structural terms / Tom Huxford, Alexander Hoffmann and Gourisankar Ghosh -- NF-[kappa]B/Rel proteins and the humoral immune responses of Drosophila melanogaster / Sandhya Ganesan ... [et al.] -- Specialized chromatin patterns in the control of inflammatory gene expression / Gioacchino Natoli -- IKK regulation and human genetics / Giles Courtois and Alain Israel -- Control of NF-[kappa]B activity by proteolysis / Veronique Baud and Emmanuel Derudder -- NF-[kappa]B and Innate immunity / Anurupa Dev ... [et al.] -- NF-[kappa]B and mucosal homeostasis / Lars Eckmann and Andrew S. Neish -- IKK- and NF-[kappa]B-mediated functions in carcinogenesis / Melek C. Arkan and Florian R. Greten -- Macrophages and NF-[kappa]B in cancer / Toby Lawrence -- NF-[kappa]B in liver cancer : The plot thickens / Shlomi Finkin and Eli Pikarsky -- NF-[kappa]B as a target for oncogenic viruses / Shao-Cong Sun and Ethel Cesarman -- Inhibition of NF-[kappa]B signaling as a strategy in disease therapy / Thomas D. Gilmore and Michael R. Garbati.
  • M09 NHG Clinical Practice Guideline Acute Otitis Media (AOM) -- M29 NHG Clinical Practice Guideline Feverish Illness in Children.
  • Global patterns of nicotine and tobacco consumption / S.K. Hammond -- Nicotine chemistry, metabolism, kinetics and biomarkers / N.L. Benowitz, J. Hukkanen and P. Jacob, 3rd -- Nicotine content and delivery across tobacco products / M.V. Djordjevic and K.A. Doran -- The road to discovery of neuronal nicotinic cholinergic receptor subtypes / A.C. Collins ... [et al.] -- Magnetic resonance imaging studies of cigarette smoking / A. Azizian ... [et al.] -- In vivo brain imaging of human exposure to nicotine and tobacco / A. Sharma and A.L. Brody -- Molecular and cellular mechanisms of action of nicotine in the CNS / J. Barik and S. Wonnacott -- The neuronal pathways mediating the behavioral and addictive properties of nicotine / D.J. Balfour -- Molecular genetics of nicotine metabolism / J.C. Mwenifumbo and R.F. Tyndale -- Sex differences in nicotine action / S. Pogun and G. Yararbas -- Recognising nicotine: the neurobiological basis of nicotine discrimination / J.W. Smith and I.P. Stolerman -- Effects of nicotine in experimental animals and humans: an update on addictive properties / B. Le Foll and S.R. Goldberg -- Discriminative stimulus effects of nicotine in humans / K.A. Perkins -- Rodent models of nicotine withdrawal syndrome / D.H. Malin and P. Goyarzu -- Approaches, challenges, and experience in assessing free nicotine / D.L. Ashley ... [et al.] -- Tobacco industry manipulation of nicotine dosing / G.F. Wayne and C.M. Carpenter -- Pharmacotherapy for tobacco dependence / R.V. Fant ... [et al.] -- Nicotine psychopharmacology: policy and regulatory / J.E. Henningfield and M. Zeller.
  • NIDA research monograph v. 5-40, 42, 44-54, 56-121, 123-143, 145-159, 161-170, 172-177, 1976-82, 1984-98.
  • Viral RNA synthesis -- Protein synthesis, structure, and processing -- Viral assembly and release -- Viral entry -- Pathogenesis of non-human coronaviruses -- Pathogenesis of arteriviruses and toroviruses -- Pathogenesis of human coronaviruses -- Vaccines, antiviral drugs, and diagnostics.
  • "This edition has several new features, reflective of the changes that have occurred in our field over the last 5 years since the fifth edition. More and more, the field of digital recording has expanded; however, in order to understand some of the shortcomings and pitfalls of digital EEG, people need to still address the issues of basic analog recording principles. With an increased use of digital recording, laboratories have collected new and different "technical artifacts." We present here an attempt to start a database for such artifacts in a hopes that future editions will continue to expand upon this and offer a fairly complete library for beginning individuals interested in our field. As noted in the fifth edition, epilepsy monitoring units (EMU's) have continued to mushroom. Similar growth has occurred in the use of EEG monitoring in newborn, cardiac, trauma, and post-operative intensive care units. With the significant advances in wireless communication and easy access to the Internet, such recordings can also be viewed and transmitted locally virtually instantaneously and can allow for well-trained clinical neurophysiologists to see and opine about patients' conditions on a very time-relevant basis. Hopefully, as future generations may show, this ability will significantly influence our patients' outcomes. Similarly, the field of intraoperative clinical neurophysiology for spinal cord function, cranial nerve function, and cranial vascular therapies has continued to evolve along with the wireless and iInternet communications. This has allowed for close monitoring of neurologic function during critical periods of operations, again with a time course that allows for corrective actions to be taken on a meaningful time frame"--Provided by publisher.
  • Print Material
  • This book describes in detail three different techniques for minimally invasive video-assisted breast surgery: nipple-sparing mastectomy with a hand-held external retractor, with a single-port device, and with robotic assistance. All three techniques can be employed for radical treatment of breast cancer or for risk reduction surgery, and the last two are brand new. The techniques are clearly explained with the aid of numerous high-quality illustrations. All surgical stages are covered in detail, and helpful information is provided on key aspects of surgical anatomy, diagnostic workup, instrumentation, and postoperative management. Nipple Sparing Mastectomy is the first manual to cover these techniques, which are likely to become standard in the field of oncological breast surgery. It will be invaluable for breast surgeons who are skilled in nipple-sparing mastectomy and oncoplastic techniques or are working in breast units that offer genetic counseling to high-risk patients.
  • Nitric oxide and cancer: an overview -- A role for eNOS in oncogenic Ras-driven cancer -- Dual role of nitric oxide in cancer biology -- Nitric oxide expression in cancer -- S-nitrosylation: how cancer cells say NO to cell death -- Cytotoxic and protective activity of nitric oxide in cancers -- Cytotoxic/protective activity of nitric oxide in cancer -- Nitric oxide and life or death of human leukemia cells -- Inhibition of apoptosis by endogenous nitric oxide in chronic lymphocytic leukaemia -- Nitric oxide: a rate-limiting factor for metastases development -- Nitric oxide inhibits tumor cell metastasis via dysregulation of the NF-kB/Snail/RKIP loop -- Sensitizing effect of nitric oxide to cytotoxic stimuli -- Nitric oxide is a promising enhancer for cancer therapy -- Role of nitric oxide for modulation of cancer therapy resistance -- Breaking resistance: role of nitric oxide in the sensitization of cancer cells to chemo- and immunotherapy -- Prognostic significance of iNOS in human melanoma -- Prognostic significance of iNOS in hepatocellular carcinoma -- Prognostic significance of iNOS in esophageal cancer -- Prognostic significance of nitrative DNA damage in infection- and inflammation-related carcinogenesis -- Nitric oxide-releasing molecules for cancer therapy and chemoprevention -- Nitric oxide: monotherapy or sensitiser to conventional cancer treatments? -- Therapeutic applications of nitric oxide for malignant tumor in animal models and human studies -- (S, R)-3-Pheynyl-4,5-dihydro-5-isoxazole acetic acid-nitric oxide (GIT-27NO): new dress for nitric oxide mission -- Nitric oxide donors are a new class of anti-cancer therapeutics for the reversal of resistance and inhibition of metastasis -- Role of inducible nitric oxide synthase (iNOS) in regulation of nitric oxide (NO) production and stabilization of nitric oxide of HIF-1a: potential role of Se-Methylselenocysteine(MSC), an antioxidant multi-targeted small molecule.
  • Section I: -- Chemical biology: Determinants of nitric oxide chemistry: inpact of cell signaling processes / Douglas D. Thomas, Wilmarie Flores-Santana, Christopher H. Switzer -- Nitric oxide redox biochemistry in lipid environments / Andrés Trostchansky, Matías N. Möller, Silvina Bartesaghi, Horacio Botti, Ana Denicola, Rafael Radi and Homero Rubbo -- Mechanisms and biological consequences of peroxynitrite-dependent protein oxidation and nitration / Madia Trujillo, Beatriz Alvarez, José M. Souza, Natalia Romero, Laura Castro, Leonor Thomson and Rafael Radi -- Systems approaches to unraveling nitric oxide response netwoeks in prokaryotes / Laura R. Jarboe, Daniel R. Hyduke and James C. Liao. Section II: -- Principles of biology: (A. Nitric oxide synthases) Uncoupling of endothelial nitric oxide synthase in cardiovascular disease and its pharmacological reversal / Ulrich Förstermann -- Tetrahydrobiopterin: an essential cofactor for nitric oxide syntahases and amino acid hydroxylases / Christina E. Higgins and Steven S. Gross -- Regulation of the expression of inducible nitric oxide synthase / Hartmut Kleinert, Julia Art and Andrea Pautz -- Molecular regulation of inducible nitric oxide synthase / Qiang Du and David A. Geller -- (B. Guanylate cyclase and cyclic GMP) Soluble guanylate cyclase: allosteric activtion and redox regulation / Adrian J. Hobbs and Johannes-Peter Stasch (C. Nitric oxide signaling) Untargeted discovery of nitric oxide-modified proteins / Ruba Deeb, Tal Nuriel and Steven S. Gross -- Fatty acid transduction of nitric oxide signaling: cyclooxygenases, lipoxygenases and nitro-fatty acids / Marsha P. Cole and Bruce A. Freeman -- Nitric oxide signaling in vascular cells is regulated through CD47 by thrombospondin-1 / Jeffery S. Isenberg, William A. Frazier and David D. Roberts -- The regulation of cell energetics and mitochondrial signaling by nitric oxide / Alberto Boveris, Maria Cecilia Carreras and Juan Jose Poderoso -- (D. Regulation of nitric oxide production) Nitric oxide-asymmetric dimedthylarginine system in endothelial cell senescence / Fortunato Scalera and Stefanie M. Bode-Böger -- (E. Nitric oxide and remodeling) The role of nitric oxide in apoptosis and autophagy: biochemical and computational studies / P. A. Loughran, E. Z. Bagci, R. Zamora, Y. Vodovotz and T. R. Billiar -- (F. Nitrite and nitrate) Nitric oxide formation from inorganic nitrate and nitrite / Jon O. Lundberg and Eddie Weitzberg -- Mechanisms of nitrite reduction in ischemia in the cardiovascular system / Andrew Webb and Amrita Ahluwalia -- Nitrite therapy for ischemic syndromes / Christopher G. Kevil and David J. Lefer -- Nitrite and heme globins: reaction mechanisms and physiological targets / Sruti Shiva, Sheila Frizzill and Mark T. Gladwin. Section III: -- Principles of pathobiology (A. Nitric oxide and cardiovascular function) Nitric oxide in vascular damage and regeneration / Claudio Napoli, Lilach O. Lerman, Maria Luisa Balestrieri and Louis J. Ignarro -- Free radicals as atherosclerotic risk in relation to nitric oxide / Toshio Hayashi and Akihisa -- The role of oxidative stress in endothelial dysfunction and vascular inflammation / Elena Osto and Francesco Cosentino -- (B. Pathophysiological mechanism of nitric oxide) Nitric oxide, oxidative stress, immune response and critical care / Claudio Napoli, Ettore Crimi, Sharon Williams-Ignarro, Filomena de Nigris and Louis J. Ignarro -- Reactive metabolites of oxygen and nitrogen in liver ischemia and reperfusion injury / Ian N. Hines and Matthew B. Grisham -- Nitric oxide in airway inflammation / Yong Chul Lee, So Ri Kim, Eun-Kyeong Jo, Hyun-Ock Pae and Hun-Taeg Chung -- Novel therapeutic applications of nitric oxide in the inhibition of tumor malignancy and reversal of resistance / Benajmin Bonavida.
  • Nitric oxide methods and protocols 2011
    Springer Protocols
    Nitric oxide physiology and pathology / David G. Hirst and Tracy Robson -- Ionizing radiation-induced DNA strand breaks and [gamma]-H2AX foci in cells exposed to nitric oxide / Kai Rothkamm and Susanne Burdak-Rothkamm -- Determination of S-nitrosothiols in biological fluids by chemiluminescence / Enika Nagababu and Joseph M. Rifkind -- Measurement of nitrite in blood samples using the ferricyanide-based hemoglobin oxidation assay / Barbora Piknova and Alan N. Schechter -- Selective fluorescent activation for bioimaging the expression of nitric oxide in cellular and in vivo systems / Junfeng Zhang and Hao Hong -- Real-time measurement of murine hippocampus NO levels in response to cerebral ischemia/reperfusion / Xiaoxiang Zheng, Kezhou Liu, and Yong Yang -- Detection of low levels of nitric oxide using an electrochemical sensor / Yong Chool Boo ... [et al.] -- Determination of the scavenging capacity against reactive nitrogen species by automatic flow injection-based methodologies / Marcela A. Segundo ... [et al.] -- Aqueous measurement of nitric oxide using membrane inlet mass spectrometry / David N. Silverman and Chingkuang Tu -- Quantum cascade laser technology for the ultrasensitive detection of low-level nitric oxide / Angela Elia ... [et al.] -- Determination of in vivo nitric oxide levels in animal tissues using a novel spin trapping technology / Anatoly F. Vanin and Alexander A. Timoshin -- [Beta] cell protection by inhibition of iNOS through lentiviral vector-based strategies / Sean O. Hynes, Cillian McCabe, and Timothy O'Brien -- Characterization of nitric oxide delivery systems produced by various nanotechnologies / Chi H. Lee -- Nitric oxide releasing nanoparticle synthesis and characterization / George Han, Adam J. Friedman, and Joel M. Friedman -- NOS antagonism using viral vectors as an experimental strategy : implications for in vivo studies of cardiovascular control and peripheral neuropathies / Beihui Liu ... [et al.]
  • Nitric oxide. 1st ed. 2007
  • Nitric oxide. Part E-F pt. E-F, 2005-2008.
    pt. F, 2008 ScienceDirect
  • Print Material
    v. 1. Introduction to the nitrofurans.
  • A Web-based learning program that shows how to search PubMed, the National Library of Medicine (NLM) journal literature search system.
  • Print Material
  • Print Material
  • Print Material
  • Print Material
    "During the past decade, the first, second and 3rd editions of the NMS Review for USMLE Step 2 have served as important adjuncts for students preparing to take the USMLE Step 2 Examination. This, the 4th edition of NMS Review for USMLE Step 2 CK, reflects the fact that it only relates to the CK (clinical knowledge) component of the current two-part Step 2 Examination. In providing this knowledge, it continues the traditions of relevance and excellence established by the previous editions"--Provided by publisher.
  • Print Material
    Basic tools for the step 2 clinical skills exam -- The medical note -- Writing medical notes and the physical examination -- Obstetrics and gynecology: writing medical notes and the physical examination -- Nervous system: writing medical notes -- Psychiatry: writing medical notes -- Pediatrics under USMLE step 2 CS -- Trauma medical notes and physical examination -- Ethics in primary care settings -- Step 2 CS cases and medical notes.
  • Print Material
    Preoperative care / Bruce E. Jarrell, Molly Buzdon, Daniel Bochicchio, Eric D. Strauch -- Postoperative care / Bruce E. Jarrell, Molly Buzdon, Eric D. Strauch -- Wound healing / Bruce E. Jarrell, Eric D. Strauch -- Thoracic and cardiothoracic disorders / Bruce E. Jarrell, Joseph S. MacLaughlin, Eric D. Strauch -- Vascular disorders / Bruce E. Jarrell, Marshall Benjamin, Eric D. Strauch -- Upper gastrointestinal tract disorders / Bruce E. Jarrell, John L. Flowers, Molly Buzdon, Eric D. Strauch -- Pancreatic and hepatic disorders / Bruce E. Jarrell, Eric D. Strauch -- Lower gastrointestinal disorders / Bruce E. Jarrell, Molly Buzdon, Daniel Bochicchio -- Endocrine disorders / Bruce E. Jarrell, W. Bradford Carter -- Skin and soft tissue disorders and hernias / Bruce E. Jarrell -- Breast disorders / Bruce E. Jarrell, Emily Bellavance, Michelle Townsend-Watts, Katherine Tkaczuk, Eric D. Strauch -- Trauma, burns, and sepsis / Bruce E. Jarrell, Thomas Scalea, Molly Buzdon -- Congenital anomalies / Clint D. Cappiello, Eric D. Strauch, Bruce E. Jarrell.
  • Gross anatomy of the brain -- Neurons and associated cells -- Basic neurophysiology -- Blood circulation and imaging -- Meninges, ventricles, and cerebrospinal fluid -- Development and growth of the nervous system -- The spinal cord -- Reflexes and muscle tone -- Pain and temperature -- Discriminative general senses, crude touch, and proprioception -- Motoneutrons and motor pathways -- Lesions of the spinal nerves and spinal cord -- Brainstem : medulla, pons, and midbrain -- Cranial nerves and chemical senses -- Neurotransmitters as the chemical messengers of certain circuits and pathways -- Auditory and vestibular systems -- Lesions of the brainstem -- Cerebellum -- The visual system -- Autonomic nervous system -- Hypothalamus -- The reticular formation and the limbic system -- Thalamus -- Basal ganglia and extrapyramidal system -- Cerebral cortex.
  • Nocturia: Causes, Consequences and Clinical Approaches is the first volume exclusively on the topic of nocturia and is designed to be a comprehensive treatise on the subject. The volume is organized into 11 chapters first introducing and defining nocturia and its impact to patients and society, followed by chapters dealing with predictors and risk factors; relationship to sleep disorders; overactive bladder; and water homeostasis. Therapeutic areas addressing nocturia are covered in specific chapters and include pharmacotherapy affecting the bladder, prostate and kidneys as well as behavioral therapy and surgical intervention. Separate chapters are devoted to alternative therapies as well as the impact of nocturia in the elderly. The volume closes with a chapter presenting avenues for future investigation into the etiology and management of nocturia. Clinical case scenarios inclusive of figures and tables illuminate the evaluation and management of patients with nocturia. Nocturia: Causes, Consequences and Clinical Approaches will give physicians and related healthcare providers the background to understand the conditions causing nocturia, how nocturia affects society and the basis for its rational treatment. It will be used as a state of the art reference by urologists, urogynecologists, internists, nephrologists, pulmonologists, endocrinologists and sleep medicine specialists.
  • In our industrialized world, we are surrounded by occupational, recreational, and environmental noise. Very loud noise damages the inner-ear receptors and results in hearing loss, subsequent problems with communication in the presence of background noise, and, potentially, social isolation. There is much less public knowledge about the noise exposure that produces only temporary hearing loss but that in the long term results in hearing problems due to the damage of high-threshold auditory nerve fibers. Early exposures of this kind, such as in neonatal intensive care units, manifest themselves at a later age, sometimes as hearing loss but more often as an auditory processing disorder. There is even less awareness about changes in the auditory brain caused by repetitive daily exposure to the same type of low-level occupational or musical sound. This low-level, but continuous, environmental noise exposure is well known to affect speech understanding, produce non-auditory problems ranging from annoyance and depression to hypertension, and to cause cognitive difficulties. Additionally, internal noise, such as tinnitus, has effects on the brain similar to low-level external noise. Noise and the Brain discusses and provides a synthesis of the underlying brain mechanisms as well as potential ways to prvent or alleviate these aberrant brain changes caused by noise exposure. Authored by one of the preeminent leaders in the field of hearing research. Emphasizes direct and indirect changes in brain function as a result of noise exposure. Provides a comprehensive and evidence-based approach. Addresses both developmental and adult plasticityIncludes coverage of epidemiology, etiology, and genetics of hearing problems; effects of non-damaging sound on both the developing and adult brain; non-auditory effects of noise; noise and the aging brain; and more.
  • Exposure to loud noise continues to be one of the largest causes of hearing loss in the adult population, already affecting some 15 percent of Americans between the ages of 20 and 69. There have been a number of discoveries and advances that have increased our understanding of the mechanisms of Noise-Induced Hearing Loss (NIHL). These advances have the potential to impact how NIHL can be prevented and how our noise standards can be made more appropriate. Noise-Induced Hearing Loss describes the effect of environmental noise on hearing, provides important background on the subject, and also explores the broader issues currently arising on effects of noise on non-human vertebrates.
  • Over the last two decades, the increasing use of noninvasive ventilation (NIV) has reduced the need for endotracheal ventilation, thus decreasing the rate of ventilation-induced complications. Thus, NIV has decreased both intubation rates and mortality rates in specific subsets of patients with acute respiratory failure (for example, patients with hypercapnia, cardiogenic pulmonary edema, immune deficiencies, or post-transplantation acute respiratory failure). Despite the increased use of NIV in clinical practice, there is still a need for more educational tools to improve clinicians' knowledge of the indications and contraindications for NIV, the factors that predict failure or success, and also what should be considered when starting NIV. This book has the dual function of being a "classical" text where the major findings in the literature are discussed and highlighted, as well as a practical manual on the tricks and pitfalls to consider in NIV application by both beginners and experts. For example, setting the ventilatory parameters; choosing the interfaces, circuits, and humidification systems; monitoring; and the "right " environment for the "right" patient will be discussed to help clinicians in their choices.
  • This book is a comprehensive but compact guide to the latest technical and technological developments in the growing field of non invasive diagnosis in clinical dermatology. Information is provided on the practical and technical characteristics of a wide range of equipment and methods for in vivo measurements that aid in the investigation of skin function, the evaluation of topically applied products, and the monitoring of skin disease. Individual sections are devoted to imaging techniques, skin analysis, superficial skin analysis, skin mechanics, water and stratum corneum hydration, and erythema and blood flow. All of the authors are experts in the field, with detailed knowledge of the techniques they describe. Non Invasive Diagnostic Techniques in Clinical Dermatology will be of value for all dermatologists, whether they are engaged in delivering patient care or in research programs, for cosmetic scientists, and for biologists involved in skin research and product assessment.
  • Do you have patients referred to you suffering from NAFLD (Non-Alcoholic Fatty Liver Disease)? Are you looking for an expert guide to the latest in clinical management? If so, this is the book for you, providing an expert and comprehensive analysis of NAFLD: what it is, why it happens, who is likely to suffer from it, and how to decide on the best management options for your patients. This book focuses clearly on providing first-rate clinical guidance as to the assessment, diagnosis and treatment of patients in the clinical setting, based wherever possible on the latest evidence and scientific understanding of disease mechanisms. NAFLD is a serious condition that is increasing in prevalence globally from year to year.
  • Introduction: defining the position of non-biological complex drugs -- Polymeric micelles -- Liposomes: the science and the regulatory landscape -- Glatiramoids -- Iron carbohydrate complexes: characteristics and regulatory challenges -- Drug nanocrystals -- Analytical methods for determining the size (distribution) in parenteral dispersions -- NBCD pharmacokinetics and bioanalytical methods to meaure drug release -- Low molecular weight heparins, biological drugs close to non-biological complex drugs -- Nanoparticle albumin-bound anticancer agents -- The EU regulatory landscape of non-biological complex drugs -- Epilogue: What did we learn? What can we expect in the future? Concluding remarks and outstanding issues -- Index.
  • v. 2, 2014 CRCnetBASE
    "There are many pharmaceuticals on the market or undergoing clinical trials that require intravenous infusion, for either short or longer periods, intermittently or continuously, and so this book should be of interest to those in pharmaceutical research and development, as well as in other research areas. These applications include chemotherapy and the treatment of various diseases such as HIV, hepatitis C, and cardiovascular disease, as well as during and following problematical surgical procedures. It is a regulatory and ethical requirement that these pharmaceuticals first be tested on both rodents and non-rodents by the clinical route, and so the range of pre-clinical experimental models is covered. The technique of prolonged intravenous delivery in conscious, free-moving animal models has also broadened the opportunities to study and evaluate the safety and efficacy of those products that have limiting biological or chemical properties such as half-life and formulation issues. In 2000 the first book covering pre-clinical infusion techniques was published by Taylor & Francis (Handbook of Pre-Clinical Continuous Intravenous Infusion, Healing and Smith, editors) and this has become the singular reference source for this technology up to the present time. However, it is now recognised that a number of the techniques have been refined since that time, and also that new and improved equipment has been developed"--Provided by publisher.
  • Introduction / Muller Gabbri -- Biogenesis and physiology of microRNAs / Carlos A. Melo and Sonia A. Melo -- Detecting noncoding RNA expression : from arrays to next-generation sequencing / Catalina Perdomo, Joshua Campbell, and Frank Schembri -- MicroRNAs in solid tumors / Jin Wang and Subrata Sen -- MicroRNAs in hematologic malignancies / Johannes Bloehdorn ... [et al.] -- miRNAs as cancer biomarkers / Edward R. Sauter -- Unraveling the complex network of interactions between noncoding RNAs and epigenetics in cancer / Veronica Davalos and Manel Esteller -- MicroRNA SNPs in cancer / Yujing LI and Peng Jin -- Bioinformatics approaches to the study of MircoRNAs / Ravi Gupta and Ramana V. Davuluri -- Beyond miRNAs : role of other noncoding RNAs in cancer / Roxana S. Redis and George A. Calin -- Translational implication for noncoding RNA in cancer / Duaa Dakhallah, Melissa Piper, and S. Patrick Nana-Sinkam.
  • Biology -- Cancer Stem Cells: A Matter of Perspective / Peter J. Quesenberry, J. Reagan, B. Ramratnam, L. Goldberg -- B and T Cell Development / Loren D. Fast -- HIV Lymphomagenesis / Liron Pantanowitz, Antonino Carbone -- Epstein-Barr Virus Lymphomagenesis and Therapeutic Targets / Huilan Rao, Roberto N. Miranda -- Antigen-Driven Lymphomagenesis / Reve Shields, James N. Butera -- Preclinical Modeling in Lymphoid Malignancies / Richa Dawar, Francisco J. Hernandez-Ilizaliturri -- Prognostic Factors -- Prognostic Factors in B-Cell Lymphomas / Diana O. Treaba, Diana O. Treaba -- Prognostic Factors in Peripheral T-Cell Lymphomas / Brady E. Beltran, Jorge J. Castillo -- Prognostic Factors in HIV-Associated Lymphoma / Jodi L. Layton, Jorge J. Castillo -- Therapy -- Future Directions in Aggressive Lymphomas / Guilherme F. Perini, Luis E. Fayad -- New Monoclonal Antibodies for Indolent Non-Hodgkin Lymphoma / Tadeusz Robak -- Current Therapies for T-cell Lymphomas / Francine M. Foss -- Overview of Stem Cell Transplantation for Lymphoma / Karen Ballen -- Autologous Hematopoietic Stem Cell Transplantation in Non-Hodgkin Lymphomas / Natthapol Songdej, Eric S. Winer -- The Role of Hematopoietic Stem Cell Transplantation for HIV-Associated Lymphomas / Pascual Balsalobre, David Serrano, Jorge Gayoso, Juan Berenguer, José L. Díez-Martín -- The Role of Hematopoietic Stem Cell Transplantation in Peripheral T-Cell Lymphomas / Jenna D. Goldberg, Carla Casulo, Steven M. Horwitz.
  • This book provides clinical practitioners and the research community with detailed information on the diagnosis, prognosis, and treatment of non-Hodgkin lymphoma, taking into account the significant growth in knowledge including multiple therapeutic advances that have been achieved over the past 5-10 years. The work is subdivided into epidemiology, pathogenesis, pathology, imaging, and therapy of the non-Hodgkin lymphomas. The full range of therapeutic options are examined according to the major subtypes of non-Hodgkin lymphoma and the most up-to-date information is provided on current standard treatment options, including stem cell transplantation as well as new cutting-edge therapeutics.
  • Non-Hodgkin lymphomas : advanced diagnostics and personalized therapies / Antonino Carbone & Anas Younes -- Lymphoma classification : past, present and future / Stefano A. Pileri, Claudio Agostinelli, Elena Sabattini, Francesco Bacci, Carlo Sagramoso, Alessandro Pileri Jr., Brunangelo Falini & Pier Paolo Piccaluga -- Immunophenotyping of non-Hodgkin lymphomas / Annunziata Gloghini & Laurence de Leval -- Pathologic diagnosis : molecular genetics / Francesco Bertoni -- Flow cytometry immunophenotyping: minimal residual disease / Pietro Bulian & Cristina Feruglio -- PET imaging / Nicolas Mounier & Nihal Martis -- Staging and prognosis / Matthew Lunning & James O. Armitage -- Which therapies for which patients / Meghan Karuturi & Anas Younes -- Chemotherapy modalities and algorithms / Chaitra Ujjani & Bruce D. Cheson -- Radiation therapy / Mauro G. Trovò & Carlo Furlan -- Cancer vaccines and active immunotherapy / Roberta Zappasodi, Paola Filipazzi, Licia Rivoltini & Massimo Di Nicola -- Stem cell transplantation in non-Hodgkin lymphomas / Jonathan Friedberg & Shahrukh Hashmi -- B-cell chronic lymphocytic leukemia/lymphoma / Piers E.M. Patten, Charles C. Chu & Nicholas Chiorazzi -- Follicular lymphoma / Stefano Luminari, Alessandra Dondi, Irene Biasoli & Massimo Federico -- Mantle cell lymphoma / Kathrin Aprile von Hohenstaufen, Alden Moccia & Emanuele Zucca -- MALT lymphoma : extranodal marginal zone B-cell lymphoma of MALT / Anastasios Stathis, Francesco Bertoni, Emanuele Zucca & Franco Cavalli -- Mycosis fungoides and other cutaneous T-cell lymphomas / Dario Tomasini, Marco Lucioni, Marco Paulli & Emilio Berti -- Peripheral T-cell lymphoma / David Sibon & Christian Gisselbrecht -- Management of elderly patients with diffuse large B-cell lymphomas / Michele Spina, Rosanna Ciancia & Umberto Tirelli -- Virus-associated non-Hodgkin lymphomas / Paolo De Paoli & Antonino Carbone -- Intrafollicular neoplasia/in situ lymphoma / Antonino Carbone & Annunziata Gloghini -- Index.
  • pt. 1. Growth -- pt. 2. Evaluation -- pt. 3. Deformities -- pt. 4. Management.
  • The demand for anesthesiologists outside of the operating room continues to grow as the number of minimally invasive procedures proliferates and the complexity of diagnostic procedures undertaken outside of the OR increase. Non-Operating Room Anesthesia is an easy-to-access, highly visual reference that facilitates an in-depth understanding of NORA procedures and protocols needed to minimize risk and complications and to maximize growth opportunities. Effectively assess and manage risks and differences in procedures through in-depth discussion.
  • "Clinical research in critical care has exploded in the past several years and we now have a much better understanding of how to care for intensive care unit (ICU) patients in areas such as management of sepsis, fluid resuscitation, mechanical ventilation, antibiotic administration, and sedation and analgesia. However, despite improved clinical care, many critically ill patients continue to experience complications of critical illness - some complications are iatrogenic and preventable, while others are simply a component of the natural history of critical illness. These complications lead to increased mortality, morbidity, cost, and long-term chronic conditions. Non-Pulmonary Complications of Critical Care: A Clinical Guide is a valuable resource for trainees and clinicians who aim to better understand and improve the quality of critical care medicine. Armed with information about potential non-pulmonary complications of ICU care and strategies to minimize or prevent those complications, the critical care clinician will be able to help ICU patients potentially avoid much of the morbidity associated with critical illness. This book is organized by organ system such that it can be easily used as a bedside reference. Complications caused by pharmaceuticals are dispersed throughout every chapter and the concluding chapters provide a special emphasis on meticulous supportive care of the critically ill patient to allow the best chance for recovery."--Publisher's website.
  • Print Material
  • Non-suicidal self-injury and eating disorders represent significant problems among today's youth and pose unique challenges for clinicians, particularly when they co-occur. This book is a rare resource in that it provides cutting-edge information on the interactions between self-injury and disordered eating, empirically informed treatments for the co-occurrence of these behaviors, and specific topics relevant to understanding nuances in the risk factors, treatment, and prevention of both self-injury and eating disorders. Practitioners, graduate students, and researchers working within this specialized area will find this text to be instrumental in advancing their knowledge and improving the treatment of self-injury in those with eating disorders.
  • Basic concepts -- Definition and proposed mechanisms of non-invasive skin tightening -- Energy devices for tightening and lifting -- Broadband light and laser -- Radiofrequency energy and hybrid devices -- Ultrasound tightening of facial and neck skin -- Tightening and lifting with sutures and implants -- Lifting with barbed sutures -- Neck lifting with implants in patients with weak chins -- Tightening and lifting with injectables -- Lifting with fat transplantation and rebalancing -- Lifting with fillers -- Lifting with neuromodulators -- Fat reduction, tightening and lifting off the face -- Non-ablative tightening and lifting on the body -- Physical stressors for fat reduction: cold, heat, and suction -- Ultrasound for fat reduction and body contouring -- Laser lipolysis -- Chemical lipolysis on the body.
  • This book is designed to provide a foundation for physicians-in-training and a quick guide to further enhance the skills set of practicing interventionalists. It is a concise reference manual covering the major aspects of clinical scenarios, procedures, and techniques. "Non-Vascular Interventional Radiology of the Abdomen" expertly addresses the planning and execution of commonly encountered procedures, including organ specific biopsies, abscess drainage, urinary interventions, gastrostomy, gastrojejunostomy, and biliary interventions.
  • Machine generated contents note: I.Development of Biophar-Maceuticals Defined as Novel Biologics -- 1.Overview of Biopharmaceuticals and Comparison with Small-molecule Drug Development / Thomas R. Gelzleichter -- Introduction -- History and Evolution of Biopharmaceuticals -- Development of Diverse Biopharmaceutical Modalities -- Comparison of Small-Molecule Drugs to Biopharmaceuticals -- Summary -- References -- 2.Regulatory Guidelines and their Application in the Nonclinical Evaluation of Biological Medicines / Maggie Dempster -- Introduction -- Species Selection -- Study Design Considerations for Repeat-Dose Studies -- Immunogenicity -- Reproductive and Developmental Toxicity -- Genotoxicity and Carcinogenicity -- Special Considerations for Anticancer Drugs -- First-in-Human (Fih) Clinical Trial -- Summary -- References -- 3.Early De-risking Strategy for Novel Biotherapeutics / Beth Hinkle -- Introduction -- Establishing A Safety Profile for Biotherapeutics -- General Safety Considerations Related to Biotherapeutics -- Progress in Evaluation of Immunotoxicity -- Can We Better Address Potential Off-Target Toxicity? -- Summary -- References -- 4.Novel Biopharmaceuticals: Pharmacokinetics, Pharmacodynamics, and Bioanalytics / Wolfgang Seghezzi -- Introduction -- Absorption, Distribution and Elimination of Biopharmaceuticals -- Disposition of Modified Molecules -- "Metabolism" and Biodistribution for Biopharmaceuticals -- Immunogenicity and impacts on PK and biodistribution -- Pharmacokinetics and Pharmacodynamics -- Preclinical to Clinical Translation -- Bioanalytics -- Drug Assays -- Biomarkers: Target Engagement Assays -- Immunogenicity Assessment: ADA Assays -- Summary -- References -- II.Development of Biosimilars -- 5.Overview of Biosimilar Therapeutics / Danuta J. Herzyk -- Introduction -- The Concept of Biosimilars -- General Considerations for Development of Biosimilars -- Biosimilar Candidates Based on Modality and Therapeutic Class -- Summary -- References -- 6.Regulatory Standards for the Approval of Biosimilar Products: A Global Review / Barbara Mounho-Zamora -- Introduction -- European Union -- Pioneer for the First Regulatory Pathway for Biosimilar Products -- The World Health Organization Guidance on Biosimilars -- Regulatory Pathway for Biosimilar Products in the United States -- Biosimilar Pathways in Other Regions -- Summary -- References -- 7.Early Characterization of Biosimilar Therapeutics / Thomas R. Gelzleichter -- Introduction -- Recombinant Insulins -- Recombinant Human Growth Hormone -- Recombinant Erythropoietins -- Recombinant Granulocyte Colony-Stimulating Factor -- Recombinant Interferons -- Low Molecular Weight Heparins -- Monoclonal Antibodies -- Other Classes -- Summary -- References -- III.Vaccines -- 8.Introduction to Vaccines and Adjuvants / Deborah L. Novicki -- Introduction -- The History of Vaccines -- The Impact of Vaccines on Human Health -- Advancements in Vaccines Technologies -- Advancements in Adjuvant Technologies -- Approved Infectious Disease Vaccines and Diseases for Which Preventive Vaccines are Still Needed -- Therapeutic Vaccines -- Product Complexity From a Quality Perspective -- Nonclinical Testing -- Clinical Testing -- Vaccine Development Using the Animal Rule -- The Anti-Vaccines Movement and Misperceptions About Vaccines and Their Safety -- Summary -- References -- 9.Global Regulatory Guidelines for Vaccines / Lisa M. Plitnick -- Introduction -- Toxicity Assessment -- Additional Toxicity Assessments -- Special Considerations -- Formulation/Delivery Devices -- Alternate Routes of Administration -- Special Considerations for Particular Types of Vaccines -- Summary -- References -- 10.Special Considerations for the Nonclinical Safety Assessment of Vaccines / Jayanthi J. Wolf -- Introduction -- De-risking Strategies for Vaccines -- Pharmacokinetics and Pharmacodynamics Assessments -- Differences in the Nonclinical Safety Assessment of Vaccines and Biopharmaceutical Drugs -- Summary -- References -- IV.Specialty Biologics and Indications -- 11.Turning the Corner with Viral-based Gene Therapy -- Development of the Rogue Biopharmaceutical / Timothy K. Maclachlan -- Introduction -- A History and Primer of Gene Therapy -- The Process of Getting Genes into Cells -- Health Authority Regulation of Gene Therapy Products -- Nonclinical Safety Studies and Regulatory Guidance -- Summary -- References -- 12.Blood Products / Vikram Arora -- Introduction -- Plasma-Derived Blood Products -- Blood Products Derived from Recombinant Technologies -- Summary -- References -- 13.Biological Therapies for Cancer / Gautham K. Rao -- Introduction -- Global Regulatory Guidances -- General Principles of Toxicology Assessments -- Nonclinical Studies and Principles of Study Design -- Specialty Toxicology Assessments -- Pharmacokinetics, Immunogenicity, and Pharmacodynamics -- Nonclinical Development of Marketed Biologies -- Recombinant Analogs of Endogeneous Human Proteins (Interferons, Cytokines, Enzymes) -- Summary -- References -- 14.Nonclinical Development of Multi-targeting Biopharmaceuticals / Anu V. Connor -- Introduction -- Scientific Rationale for Multi-Targeting Biopharmaceuticals (MTBs) -- Evolution of Technology Platforms -- General Challenges and Considerations -- Summary of Challenges -- T Cell-Dependent Bispecific Antibody (TDB) Biotherapeutics -- Dual-Targeting Antibodies -- Summary -- References -- 15.Considerations in the Development of Pluripotent Stem Cell-based Therapies / Joy A. Cavagnaro -- Introduction -- Early Decisions -- Nonclinical Development -- Translating Preclinical Data to Clinical Application -- Global Regulatory Guidance -- Summary -- References.
  • Nonclinical Study Contracting and Monitoring: A Practical Guide offers a systematic and straightforward handbook for obtaining high quality preclinical Good Laboratory Practice (GLP) studies. This book is full of real-world examples, processes, procedures, useful templates, checklists and sample reports to provide readers with a better understanding of exactly what happens during all stages of a GLP study and the critical aspects of GLP study design and conduct.
  • This book offers a complete overview on noncolorectal nonneuroendocrine (NCRNNE) liver metastases and describes in detail the currently available therapies. Each chapter focuses on the treatment of metastases from a particular primary malignancy and also provides valuable information on incidence, natural history, and diagnosis. NCRNNE metastases to the liver are rare entities compared with colorectal and neuroendocrine metastases, for which the treatments are well codified. While more publications have appeared on the topic in recent years, an in-depth study has to date been lacking. Furthermore, most published series are insufficiently comparable as they comprise patients with NCRNNE hepatic metastases from a variety of primary malignancies and consequently overlook differences in tumor behavior, frequency of isolated hepatic metastases, response to neoadjuvant or adjuvant therapy, and interval between diagnosis of the primary tumor and the liver metastases. This book, with its more specific approach, will serve not only as an up-to-date guide to diagnosis and treatment but also as a reference on which to base future studies.
  • Diseases of the respiratory system often cause multisystem dysfunction and morbidity. Respiratory diseases not transmissible by a direct contact are rarer than those of inflammatory or infectious background. Such noncommunicable diseases, often entailing genetic and immune aspects, are areas of limited understanding; sarcoidosis being a case in point. This book tackles the issues relevant to such diseases. The research on novel cytokine markers, which may help in the diagnosis and management of sarcoidosis, is described. Modern approaches to the management of pneumothorax, a frequent accompaniment of lung diseases or chest wall trauma are dealt with as well. There are also chapters that underscore the immuno-inflammatory mechanisms of disorders seemingly unrelated to respiration, such as obesity or aplastic anemia, which may appreciably affect the control of the respiratory system and thus its vulnerability to diseases. The book will be of interest to clinicians and medical researchers.
  • Introduction to forensic science and DNA / Heather Miller Coyle -- Collection and preservation of biological evidence from the crime scene / Henry C. Lee -- Techniques of DNA fingerprinting / John Schienman -- Forensic canine STR analysis / Burkhard Berger, Cordula Eichmann, Walther Parson -- STR based forensic analysis of field samples from domestic and exotic cats / Marilyn A. Menotti-Raymond, Victor A. David, Stephen J. O'Brien -- Overview of insect evidence in forensic science / Heather Miller Coyle -- Use of forensic DNA typing in wildlife investigations / Richard M. Jobin -- DNA testing of animal evidence : case examples and method development / En-Uei Jiang, W. A. van Haeringen, L. H. P. van de Goor, Pero Dimsoski, Heather Miller Coyle -- Basics of forensic fungi /; Khudooma Said Al Na'imi -- Soil DNA typing in forensic science / Jonathan Hill, Linda Strausbaugh, Joerg Graf -- DNA profiling : the ability to predict an image from a DNA profile / Holly Long -- Appendix A: Brief history of forensic serology and DNA / Peter Bilous.

Access restricted to Stanford community

Shortcut to Licensed Content

Lane Gateway to Licensed Content

TO INSTALL, DRAG THIS BUTTON to your browser Bookmarks or Tools Bar.

What is it?

Lane Gateway to Licensed Content

Bookmark on Other Websites

Bookmark on Lane

  • TO INSTALL, RIGHT CLICK this button.
  • Select "Add to Favorites" (click “Continue” if you see a security alert)
  • From the "Create in" menu, select “Favorites Bar” (IE8, IE9) to install
  • Once installed it will look like this
  • Click "Bookmark on Lane" to bookmark any webpage
  • Your saved bookmark will appear on this page

What is it?

A repository of medical knowledge from internal medicine, cardiology, genetics, pharmacy, diagnosis and management, basic sciences, patient care, and more. Continuously expanding, all databases in the repository contain the latest editions of selected medical titles.MicroMedex: Premier pharmaceutical information source containing multiple databases and drug reference tools. Of particular value is DRUGDEX Evaluations, one of the most comprehensive drug sources available.DynaMed is a clinical information resource used by physicians to answer clinical questions quickly and easily at the point of care. Topics are updated daily as new evidence becomes available. Scopus is the largest abstract and citation database of peer-reviewed literature: scientific journals, books and conference proceedings.A drug information resource containing: American Hospital Formulary System (AHFS), drug formulary for Lucile Packard Children's Hospital (LPCH) and Stanford Hospital & Clinics (SHC), Lexi-Drugs (adverse reactions, dosage and administration, mechanism of action, storage, use, and administration information), Lexi-Calc, Lexi-ID, Lexi-I.V. Compatibility (King Guide), Lexi-Interact, and Lexi-PALS.Cumulative Index to Nursing and Allied Health Literature (CINAHL) contains coverage of nursing and allied health literature.A knowledge database that provides access to topic reviews based on over 6000 clinically relevant articles. The evidence-based content, updated regularly, provides the latest practice guidelines in 59 medical specialtiesProvides critical assessments of systematic reviews compiled from a variety of medical journals.Selects from the biomedical literature original studies and systematic reviews that are immediately clinically relevant and then summarizes these articles in an enhanced abstract with expert commentary.Multidisciplinary coverage of over 10,000 high-impact journals in the sciences, social sciences, and arts and humanities, as well as international proceedings coverage for over 120,000 conferences. Includes cited reference searching, citation maps, and an analyze tool.Features systematic reviews that summarize the effects of interventions and makes a determination whether the intervention is efficacious or not. Cochrane reviews are created through a strict process of compiling and analyzing data from multiple randomized control trials to ensure comprehensiveness and reliability.Provides systematic coverage of the psychological literature from the 1800s to the present through articles, book chapters and dissertations.BMJ Clinical Evidence. A clinical information tool built around systematic reviews summarizing the current state of knowledge about prevention and treatment of clinical conditions.PIER (Physicians' Information and Education Resource) is a Web-based decision-support tool designed for rapid point-of-care delivery of up-to-date, evidence-based guidance for primary care physicians.Cochrane Central Register of Controlled Trials (CENTRAL) provides access to 300,000 controlled trials that have been identified the Cochrane Collaboration.Provides drug information targeted for patients.A continually updating drug monograph.The National Guideline Clearinghouse (NGC): A comprehensive database of evidence-based clinical practice guidelines and related documents.MedlinePlus: A repository of health information from the National Library of Medicine. Links are from trusted sites. No advertising, no endorsement of commercial companies or productsLPCH CareNotes via MicroMedex: Patient education handouts customized by LPCH clinical staffMicromedex Lab Advisor: Evidence based laboratory test informationA drug database organized by generic name, trade name and drug class.LPCH / Stanford Hospital Formulary.A goldmine of trusted consumer health information from the world's largest medical library.A trusted source of expert advice for and about kids, providing the information necessary to help patients and parents understand their unique needs.Provides patient handouts from the American Academy of Family Physician.Access to the Stanford Health Library for patients.Lane provides access to over 5,000 eBooks many of which provide helpful background material that will prepare you to better tackle primary literature.Largest, broadest eBook package; covers all sciences, as well as technology (including software), medicine, and humanities. In addition to covering Wiley and Springer, MyiLibrary is also the only provider for Oxford and Cambridge University Press titles. No seat restrictions.A collection of biomedical books that can be searched directly by concept, and linked to terms in PubMed abstracts.A web-based, decision support system for infectious diseases, epidemiology, microbiology and antimicrobial chemotherapy. The database, updated weekly, currently includes 337 diseases, 224 countries, 1,147 microbial taxa and 306 antibacterial (-fungal, -parasitic, -viral) agents and vaccines. Over 10,000 notes outline the status of specific infections within each country.
Large number of high quality software and database programming titles from O'Reilly. Other software titles are also available from Sams and Prentice Hall. Limited to 7 concurrent users.Vast collection of software and database programming titles from multiple publishers, including Microsoft Press.Largest provider of engineering-related eBooks; includes titles in computer science and biomedical engineering.Over 4,000 full-text e-books covering scientific and technical information from CRC Press and others. Many handbooks and single volume reference sources.Includes peer-reviewed life science and biomedical research protocols compiled from Methods in Molecular Biology, Methods in Molecular Medicine, Methods in Biotechnology, Methods in Pharmacology and Toxicology, Neuromethods, the Biomethods Handbook, the Proteomics Handbook, and Springer Laboratory Manuals.Contains full text access to selected biomedical and nursing books.Provides online, full-text access to Springer's journal titles as well as journals from other publishers. Subjects include: life sciences, chemical sciences, environmental sciences, geosciences, computer science, mathematics, medicine, physics and astronomy, engineering and economics. Also includes eBooks.Collection of over 8 thousand fulltext titles in engineering, math, and basic and applied biomedical research. Coverage is from 1967 to the present.A library of ebooks on a wide array of topics, digitized and made available online in conjunction with the original publishers.