Books

M

  • Digital
    Committee on the Methodological Challenges in HIV Prevention Trials, Board on Global Health, Institute of Medicine of the National Academies ; Stephen W. Lagakos and Alicia R. Gable, editors.
    Digital : NAP2008
    "This IOM committee was formed at the request of the Bill & Melinda Gates Foundation and charged with addressing methodological challenges in late-stage nonvaccine biomedical HIV prevention trials with a specific focus on microbicide and pre-exposure prophylaxis trials."
  • Print
    Print1963-
    Status: Not Checked OutLane Catalog Record
  • Digital
    Joel Thomas Dudley.
    Digital2011
    One of the grand challenges in genomic medicine is to translate fundamental scientific discoveries regarding the structure, variation, and function of the genomes of individuals and populations towards improved health outcomes. The main hypothesis of this thesis is that all forms of human genetic variation contributing to the etiology and pathophysiology of modern human diseases have distinct and quantifiable evolutionary histories, which can be computed for every position in the human genome independent of human population characteristics, and used as informative quantitative priors in the discovery and assessment of variants of clinical importance in modern human populations. To enable robust evaluation of the specific questions posed by this thesis, I first explore the necessary properties and theoretical basis for a null evolutionary hypothesis for Evolutionary Genomic Medicine, and conclude that the well-established Neutral Theory of Molecular Evolution provides a sound theoretical and methodological basis for evaluating alternative hypothesis in Evolutionary Genomic Medicine. Due to advances in multiplex genotyping technologies, genome-wide associations studies (GWAS), have emerged as the premier modality for discovery and assessment clinical genomic variation. Although these efforts have been successful in revealing thousands variants robustly associated with a broad spectrum of clinical phenotypes, the variants established by the GWAS approach have so far failed to explain large proportions of the known genetic variance associated with important clinical traits such as Type 2 Diabetes and Hypertension. Because disease-associated variation is linked with genomic loci of functional importance which have undergone evolutionary selection, and even the proxy loci (e.g. tagging SNPs) used to probe for disease associated loci themselves have quantifiable evolutionary histories, I evaluate a compendium of disease-associated variants to evaluate the effect of long-term evolutionary histories on the discovery of disease-associated variants. Through this work I demonstrate that disease-associated variants have distinct evolutionary properties, and that evolutionary features of positions can be incorporated as priors to improve discovery of disease-associated variants. A similar approach is applied to evaluate pharmacogenomics variants associated with warfarin, demonstrating that evolutionary features of genomic positions improve clinical assessment of pharmacogenomics variation. Through the findings and insights gained from efforts in pursuit of my thesis which are reported here, my collaborators and I clearly demonstrate that quantitative evolutionary features can be estimated for each position in the human genome across species, and then applied to modern human population data to improve discovery and assessment of genomic variation associated with clinical phenotypes.
  • Digital
    edited by N. Balakrishnan.
    Digital : Wiley2014
  • Digital
    edited by N. Balakrishnan.
    Digital : Wiley2014
  • Digital
    Digital : Wileyv. 11-, 2000-
  • Digital
    Greg Duncan, Virginia Lesser, Barbara Entwisle, Graham Kalton, Andy Shih, Elaine Faustman, Rosalind Wright, Kerry Anne McGeary, Richard Gershon, Steven Wysmuller, Shelley Merritt, and Charlee Alexander.
    Digital2016
    As outlined in the previous paper in this series (Riley et al., 2016), our nation needs foundational data in order to understand how social, physical, chemical, and nutritional environments interact to impact how Americans grow, live, and prosper. To satisfy this need, we propose a nationally representative birth cohort study beginning in the prenatal period and following the children through adulthood. Existing research efforts are in adequate because their data are not sufficiently comprehensive and representative to identify both positive and negative factors affecting children's health or to fully understand health inequities in the United States. A crucial element of the proposed study is a well-designed national probability sample from which conclusions can be drawn to the larger population from which the sample was randomly selected. In contrast, self-selection sampling consists of volunteers who elected to be part of a study. This technique introduces self-selection bias and can lead to a sample that is not representative of the population being studied. In fact, a report by the National Research Council (NRC) and the Institute of Medicine (IOM), The National Children's Study 2014: An Assessment, endorsed a probability sample design for a future national longitudinal birth cohort study (NRC/IOM, 2014; Riley et al., 2016). This paper provides an overview of a feasible sample design, methods for stakeholder engagement, tools for data collection, and approaches for providing access to the data that would maximize its value.
  • Digital
    edited by Franck Perez and David J. Stephens.
    Digital : ScienceDirect2013
  • Print
    David W. Hecht, Diane M. Citron, Joanne Dzink-Fox, William W. Gregory, Nilda V. Jacobs, Stephen G. Jenkins, Jon E. Rosenblatt, Audrey N. Schuetz, Hannah Wexler.
    Print2012
    Status: Not Checked OutLane Catalog Record
  • Print
    Lucinda Kay Southworth.
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Miguel A.L. Nicolelis.
    Digital : CRCnetBASE2008
    Chronic recording during learning / Aaron J. Sandler -- Defining global brain states using multielectrode field potential recordings / Shih-Chieh Lin and Damien Gervasoni -- Multielectrode recording in behaving monkeys / R.E. Crist and M.A. Lebedev -- Neural ensemble recordings from central gustatory-reward pathways in awake and behaving animals / Albino J. Oliveira-Maia, Sidney A. Simon, and Miguel A.L. Nicolelis -- Building brain-machine interfaces to restore neurological functions / Mikhail A. Lebedev, Roy E. Crist, and Miguel A.L. Nicolelis -- Conceptual and technical approaches to human neural ensemble recordings / Dennis A. Turner, Parag G. Patil, and Miguel A.L. Nicolelis. State-of-the-art microwire array design for chronic neural recordings in behaving animals / Gary Lehew and Miguel A.L. Nicolelis -- Surgical techniques for chronic implantation of microwire arrays in rodents and primates / Laura M.O. Oliveira and Dragan Dimitrov -- Technology for multielectrode microstimulation of brain tissue / Timothy Hanson, Nathan Fitzsimmons, and Joseph E. O'Doherty -- Strategies for neural ensemble data analysis for brain-machine interface (BMI) applications / Miriam Zacksenhouse and Simona Nemets -- Chronic recordings in transgenic mice / Kafui Dzirasa -- Multielectrode recordings in the somatosensory system / Michael Wiest, Erik Thomson, and Jim Meloy --
  • Digital
    edited by Craig W. Stevens.
    Digital : Springer Protocols2011
    In silico identification of novel G protein-coupled receptors / Matthew N. Davies, David E. Gloriam, and Darren R. Flower -- Alternative pre-mRNA splicing of G protein-coupled receptors / Ying-Xian Pan, Steven Grinnell, and Gavril W. Pasternak -- Detecting polymorphisms in G protein-coupled receptor genes / Dmitri Proudnikov, Vadim Yuferov, and Mary Jeanne Kreek -- Regulation of the transcription of G protein-coupled receptor genes / Cheol Kyu Hwang [and others] -- Deciphering the evolution of G protein-coupled receptors in vertebrates / Craig W. Stevens -- New approach to visualize endogenously expressed G protein-coupled receptors in tissues and living cells / Gregory Scherrer and Brigitte L. Kieffer -- Posttranslational regulation of G protein-coupled receptors / Yu Qiu and Ping-Yee Law -- Discovering G protein-coupled receptor motifs mediating export from the endoplasmic reticulum / Chunmin Dong and Guangyu Wu -- Identifying G protein-coupled receptor escorts, chaperones, and intracellular tethers regulating receptor density at the cell surface / Stefano Marullo, Liliana Pardo Lopez, and Lamia Achour -- Novel method for determining the kinetics of G protein-coupled receptor plasma membrane expression / Gregory W. Sawyer -- Characterizing the pharmacology of G protein-coupled receptors in transfected cell lines / Kathryn A. Seely and Paul L. Prather -- Novel assay technologies for the discovery of G protein-coupled receptor drugs / Elisa Alvarez-Curto, Richard J. Ward, and Graeme Milligan -- Discovering cell type-specific patterns of G protein-coupled receptor phosphorylation / Kok Choi Kong, Andrew B. Tobin, and Adrian J. Butcher -- Quantifying allosteric modulation of G protein-coupled receptors / Frederick J. Ehlert and Hinako Suga -- Experimental designs for the study of receptor-receptor interactions / Dennis Paul -- Elucidating agonist-selective mechanisms of G protein-coupled receptor desensitization / Chris P. Bailey and Eamonn Kelly -- Detecting the role of arrestins in G protein-coupled receptor regulation / Laura M. Bohn and Patricia H. McDonald -- Characterizing molecular mobility and membrane interactions of G protein-coupled receptors / Vladana Vukojevice, Yu Ming, and Lars Terenius -- Using RNA interference to downregulate G protein-coupled receptors / Philippe Sarret [and others] -- Upregulating G protein-coupled receptors with receptor antagonists / Ellen M. Unterwald.
  • Print
    Michael F. Drummond, Mark J. Sulpher, Karl Claxton, Greg L. Stoddart, George W. Torrance.
    Print2015
    Status: Not Checked OutLane Catalog Record
  • Digital
    Konrad J. Karczewski.
    Digital2013
    Most human variation lies outside of coding regions, where molecular functions are more difficult to determine than for variants in coding regions. As most disease-associated variants lie in non-coding regions, characterizing the role of regulatory variation is crucial to understanding the molecular mechanisms of these diseases and methods to do so are currently limited. Recently, a number of research efforts, including the ENCODE project, have produced a wealth of data on transcription factor binding sites and other regulatory information, in addition to increasingly available whole genome sequence and transcriptomics data. These data will crucial to understanding the molecular basis of many diseases, but their scale and disparate nature, as well as high levels of noise, require clever informatics methods to integrate and properly apply this information. In this thesis, I describe methods to address some of the major informatics challenges to characterize the role of regulatory variants in phenotypes and disease. In particular, I have shown that I can (1) detect cooperativity among transcription factors using human variation data, (2) associate transcription factors to functional modules and thus discover new TF interactions and disease associations, (3) provide molecular mechanisms for disease-associated non-coding variants, and (4) explore regulatory functional mechanisms using long-range interactions in the human genome.
  • Digital
    edited by Stephanie M. Chang, David B. Matchar [and others].
    Digital2012
    DigitalNCBI
    "Effectiveness and Comparative Effectiveness Reviews, systematic reviews of existing research on the effectiveness, comparative effectiveness, and comparative harms of different medical tests, are intended to provide relevant evidence to inform real-world health care decisions for patients, providers, and policymakers. In an effort to improve the transparency, consistency, and scientific rigor of the work of the Effective Health Care (EHC) Program, the Agency for Healthcare Research and Quality (AHRQ), the Scientific Resource Center, and the Evidence-based Practice Centers (EPCs), have developed this Methods Guide for Medical Test Reviews (also referred to as the Medical Test Methods Guide). We intend it to serve as a resource for the EPCs as well as for other investigators interested in conducting systematic reviews on medical tests. We hope it will be a practical guide both for those who prepare the systematic reviews and those who use them in clinical practice, research development, and in making policy decisions."
  • Digital
    edited by Joakim Dillner.
    Digital : Springer Protocols2011
    Genetic research and biobanks / D. Chalmers -- The need to downregulate: A minimal ethical framework for biobank research / M.G. Hansson -- Nordic biological specimen bank cohorts as basis for studies of cancer causes and control: Quality control tools for study cohorts with more than two million sample donors and 130,000 prospective cancers / E. Pukkala -- Biobanks collected for routine healthcare purposes: Build-up and use for epidemiologic research / J. Dillner and K. Andersson -- Biobanks and registers in epidemiologic research on cancer / E. Pukkala -- Study designs for biobank-based epidemiologic research on chronic diseases / E. Laara -- The European prospective investigation into cancer and nutrition biobank / P. Hainaut ... [et al.] -- The aids and cancer specimen resource / L.W. Ayers ... [et al.] -- Specific advantages of twin registries and biobanks / J. Kaprio -- The Swedish multi-generation register / A. Ekbom -- Multigenerational information: The example of the Icelandic genealogy database / H. Tulinius -- Creation of a new prospective research biobank: The example of HUNT3 / K. Hveem -- Best practices for establishing a biobank / G. Hallmans and J.B. Vaught -- Extraction, quantitation, and evaluation of function DNA from various sample types / M. Ivarsson and J. Carlson -- Cervical cytology biobanks as a resource for molecular epidemiology / M. Arbyn ... [et al.] -- Biobanking of fresh frozen tissue from clinical surgical specimens: Transport logistics, sample selection, and histologic characterization / J. Botling and P. Micke -- Protein extraction from solid tissue / C. Ericsson and M. Nister -- Collection and preservation of frozen microorganisms / R. Tedeschi and P. De Paoli -- Handling of solid brain tumor tissue for protein analysis / C. Ericsson and M. Nister -- Blood plasma handling for protein analysis / C. Ericsson and M. Nister -- Biobank informatics: Connecting genotypes and phenotypes / J.E. Litton -- A practical guide to constructing and using tissue microarrays / I. Chandler, R. Houlston and G. Landberg -- Breast cancer genomics based on biobanks / A. Forsti and K. Hemminki -- Monitoring, alarm, and data visualization service on sample preparing and sample storing devices in biobanks / H. Hauksdottir, K. Jonsdottir and A. Thorarinsson -- Fresh frozen tissue: RNA extraction and quality control / J. Botling and P. Micke.
  • Digital
    edited by Indra Neil Sarkar.
    Digital : ScienceDirect2014
    Seeking to cross the bridge among overview, theory, and practice, this book incorporates both methodological approaches and their potential application in the domains associated with biomedical informatics.The multi-contributor book is useful for (1) those coming from a domain seeking biomedical informatics approaches for addressing specific needs; and, (2) current biomedical informaticians seeking a foundational background for methods that might be utilized in practical scenarios germane to their ongoing research.A unique characteristic of the text is its balance between foundational coverage of core topics in biomedical informatics with practical "in-the-trenches" scenarios. Contributors represent leading experts from the biomedical informatics field: individuals who have demonstrated effective use of methodology in real-world, high-quality data applications. Contains appendices that function as primers on: (1) Unix; (2) Ruby; (3) Databases; and (4) Web Services.
  • Digital
    Walker, John M.
    Digital : Springer Protocolsv. 1-24, 1997-2007
  • Digital
    edited by Koichi Sameshima, Luiz Antonio Baccala.
    Digital : CRCnetBASE2014
  • Digital
    prepared under the auspices of the American Society for Cell Biology ; edited by Josephine C. Adams.
    Digital : ScienceDirect2002
    Print2002
  • Digital
    edited by Renata Basto and Wallace F. Marshall.
    Digital : ScienceDirect2015
    Imaging centrosomes and cilia in the mouse kidney / Masato Hoshi, Jinzhi Wang, Sanjay Jain, Moe R. Mahjoub -- Ependymal cell differentiation, from monociliated to multiciliated cells / Nathalie Delgehyr, Alice Meunier, Marion Faucourt, Montserrat Bosch Grau, Laetitia Strehl, Carsten Janke, Nathalie Spassky -- Observing planar cell polarity in multiciliated mouse airway epithelial cells / Eszter K. Vladar, Yin Loon Lee, Tim Stearns, Jeffrey D. Axelrod -- Imaging and analyzing primary cilia in cardiac cells / Nicolas Diguet, Jean-Francois Le Garrec, Tommaso Lucchesi, Sigolene M. Meilhac -- Cilia in photoreceptors / Linjing Li, Manisha Anand, Kollu Nageswara Rao, Hemant Khanna -- Analysis of primary cilia in the developing mouse brain / Judith T.M.L. Paridaen, Wieland B. Huttner, Michaela Wilsch-Brauninger -- In vivo investigation of cilia structure and function using Xenopus / Eric R. Brooks, John B. Wallingford -- A quantitative approach to study endothelial cilia bending stiffness during blood flow mechanodetection in-vivo / Francesco Boselli, Jacky G. Goetz, Gilles Charvin, Julien Vermot -- Quantitative description of fluid flows produced by left-right cilia in zebrafish / Craig Fox, M. Lisa Manning, Jeffrey D. Amack -- Efficient live fluorescence imaging of intraflagellar transport in mammalian primary cilia / Hiroaki Ishikawa, Wallace F. Marshall -- Analysis of soluble protein entry into primary cilia using semipermeabilized cells / David K. Breslow, Maxence V. Nachury -- Methods for imaging individual cilia in living echinoid embryos / Robert L. Morris, Hans W. Pope, Adam N. Sholi, Leah M. Williams, Chelsea R. Ettinger, Gwendolyn M. Beacham, Tatsushi Shintaku, Zachary D. Abbott, Elyse M. Doherty -- The planarian Schmidtea mediterranea as a model for studying motile cilia and multiciliated cells / Cyril Basquin, Anne-Marie Orfila, Juliette Azimzadeh -- Quantitative analysis of flagellar proteins in Drosophila sperm tails / Teresa Mendes Maia, Perrine Paul-Gilloteaux, Renata Basto -- Imaging cilia in Drosophila melanogaster / Jennifer Vieillard, Jean-Luc Duteyrat, Elisabeth Cortier, Benedicte Durand -- Studying G protein-coupled receptors: Immunoblotting, immunoprecipitation, phosphorylation, surface labeling, and cross-linking protocols / Kasturi Pal, Hemant Badgandi, Saikat Mukhopadhyay -- Image analysis of Caenorhabditis elegans ciliary transition zone structure, ultrastructure, molecular composition and function / Anna A. W. M. Sanders, Julie Kennedy, Oliver E. Blacque -- Genetic and genomic approaches to identify genes involved in flagellar assembly in Chlamydomonas reinhardtii / Huawen Lin, Susan K. Dutcher -- Axonemal motility in Chlamydomonas / Ken-ichi Wakabayashi, Ritsu Kamiya -- Posttranscriptional control over rapid development and ciliogenesis in marsilea / Stephen M. Wolniak, Thomas C. Boothby, Corine M. van der Weele -- Total internal reflection fluorescence microscopy of intraflagellar transport in tetrahymena thermophila / Yu-Yang Jiang, Karl Lechtreck, Jacek Gaertig -- Ciliary heterogeneity within a single cell : the paramecium model / Anne Aubusson-Fleury, Jean Cohen, Michel Lemullois -- Imaging intraflagellar transport in trypanosomes / Julien Santi-Rocca, Nicolas Chenouard, Cécile Fort, Thibault Lagache, Jean-Christophe Olivo-Marin, Philippe Bastin -- Scanning and three-dimensional electron microscopy methods for the study of trypanosoma brucei and leishmania mexicana flagella / Eva Gluenz, Richard John Wheeler, Louise Hughes, Sue Vaughan.
  • Print
    edited by Joseph Larner, Stephen L. Pohl.
    Status: Not Checked OutLane Catalog Record
    v. 1. Laboratory methods, pts. A-C -- v. 2. Clinical methods.
  • Digital
    Abelson, John N.; Colowick, Sidney P.; Kaplan, Nathan Oram; Simon, Melvin I.
    Digital : ScienceDirectv. 1-, 1955-
  • Digital
    Dennis, Edward A.; Dennis, Martha G.; Dewey, Virginia C.
    Digital : ScienceDirect1964-Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 1-30)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 31-32, 34-60)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 61-74, 76-80)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 81-94, 96-101)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 102-119, 121-134)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 135-139, 141-167)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 168-174, 176-194)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 195-198, 200-227)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 228, 230-262)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 263, 264, 266-289)Indexes to v. 1-<320>
    Digital : ScienceDirectFulltext (Index to v. 290-319)Indexes to v. 1-<320>
    v. 7 (1964). Volumes I through VI / prepared by Virginia C. Dewey (ix, 266 p.) -- v. 33 (1975). Volumes I-XXX / edited by Martha G. Dennis, Edward A. Dennis (xxv, 1078 p.) -- v. 75 (1982). Volumes 31, 32 and 34-60 (xxv, 1078 p.) -- v. 95 (1985). Volumes 61-74, 76-80 (xxviii, 402 p.) -- v. 120 (1986). Volumes 81-94 and 96-101 -- v. 140 (1988). Volumes 102-119 and 121-134 -- v. 175 (1990). Volumes 135-139, 141-167 -- v. 199 (1993). Volumes 168-174, 176-194 -- v. 229 (1995). Volumes 195-198 and 200-227 -- v. 265 (1996). Volumes 228, 230-262 -- v. 285 (1998). Volumes 263, 264, 266-289 -- v. 320 (2000). Volumes 290-319 -- v. 355 (2002). Subject index to volumes 33, 75, 95, 120, 140, 175, 199, 229, 265, 285 and 320.
  • Print
    Dorfman, Ralph I.
    Status: Not Checked OutLane Catalog Record
    v. 1. Chemical determinations -- v. 2. Bioassay -- v. 3. & 4. Steroidal activity in experimental animals and man, Part A & B.
  • Digital
    edited by Dylan M. Owen.
    Digital : Springer Protocols2015
    Introduction to membrane lipids /Richard M. Epand -- Introduction : membrane properties (good) for life /Marek Cebecauer -- Introduction to fluorescence probing of biological membranes /Alexander P. Demchenko ... [et al.] -- Assembly and use of tethered bilayer lipid membranes (tBLMs) /Charles Cranfield ... [et al.] -- Preparation of detergent-resistant membranes (DRMs) from cultured mammalian cells /Deborah A. Brown -- Isolation of giant plasma membrane vesicles for evaluation of plasma membrane structure and protein partitioning /K. R. Levental and I. Levental -- Asymmetric giant lipid vesicle fabrication /Peichi C. Hu and Noah Malmstadt -- Cholesterol depletion using Methyl-[Beta]-cyclodextrin /Saleemulla Mahammad and Ingela Parmryd -- Comparative LC-MS based profiling approach to analyze lipid composition in tissue culture systems /G. Ekin Atilla-Gokcumen and Ulrike S. Eggert -- Imaging membrane order using environmentally sensitive fluorophores /G.W. Ashdown and Dylan M. Owen -- 3D super-resolution imaging by localization microscopy /Astrid Magenau and Katharina Gaus -- Electron microscopy methods for studying plasma membranes /Alison J. Beckett and Ian A. Prior -- Measuring cytoskeleton and cellular membrane mechanical properties by atomic force microscopy /Charles Roduit ... [et al.] -- Fluorescence linear dichroism imaging for quantifying membrane order /Richard K. P. Benninger -- Scanning fluorescence correlation spectroscopy on biomembranes /Eduard Hermann, Jonas Ries, and Ana J. García-Sáez -- X-ray diffraction of lipid model membranes /Arwen I. I. Tyler, Robert V. Law, and John M. Seddon -- Solid state NMR of lipid model membranes /Arwen I. I. Tyler ... [et al.] -- Fluorescence recovery after photobleaching (FRAP) : acquisition, analysis, and applications /Michael Carnell, Alex Macmillan, and Renee Whan -- Laurdan spectral phasor method to explore membrane micro-heterogeneity and lipid domains in live cells /Ottavia Golfetto, Elizabeth Hinde, and Enrico Gratton -- Cholesterol behavior in asymmetric lipid bilayers : insights from molecular dynamics simulations /Semen O. Yesylevskyy and Alexander P. Demchenko -- Computer simulations of phase separation in lipid bilayers and monolayers /Svetlana Baoukina and D. Peter Tieleman.
  • Digital
    edited by Alex M. Dopico.
    Digital : Springer Protocols2007
  • Digital
    edited by Amy C. Rosenzweig, Stephen W. Ragsdale.
    Digital : ScienceDirect2011
    Print2011
    1. Techniques for cultivating methanogens / Ralph S. Wolfe -- 2. Genetic methods for methanosarcina species / Nicole Buan, Gargi Kulkarni, and William Metcalf -- 3. Genetic systems for hydrogenotrophic methanogens / Felipe Sarmiento B., John A. Leigh, and William B. Whitman -- 4. Molecular tools for investigating ANME community structure and function / Steven J. Hallam ... [et al.] -- 5. Studying gene regulation in methanogenic archaea / Michael Rother, Christian Sattler, and Tilmann Stock -- 6. Growth of methanogens under defined hydrogen conditions / John A. Leigh -- 7. Preparation of [Fe]-hydrogenase from methanogenic archaea / Seigo Shima, Michael Schick, and Haruka Tamura -- 8. Assay of methylotrophic methyltransferases from methanogenic archaea / Donald J. Ferguson, David G. Longstaff, and Joseph A. Krzycki -- 9. Methyl-coenzyme M reductase from methanothermobacter marburgensis / Evert C. Duin, Divya Prakash, and Charlene Brungess -- 10. Methods for analysis of acetyl-CoA synthase : applications to bacterial and archaeal systems / David A. Grahame -- 11. Acetate kinase and phosphotransacetylase / James G. Ferry -- 12. Sodium ion translocation and ATP synthesis in methanogens / Katharina Schlegel and Volker Müller -- 13. Proton translocation in methanogens / Cornelia Welte and Uwe Deppenmeier -- 14. Measuring isotope fractionation by autotrophic microorganisms and enzymes / Kathleen M. Scott, Gordon Fox, and Peter R. Girguis -- 15. 2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis / David E. Graham -- 16. Biomethanation and its potential / Irini Angelidaki ... [et al.].
  • Digital
    edited by Amy C. Rosenzweig, Stephen W. Ragsdale.
    Digital : ScienceDirect2011
    Print2011
  • Digital
    edited by Phillip Stafford.
    Digital : CRCnetBASE2008
    Print2008
    A comprehensive analysis of the effect of microarray data preprocessing methods on differentially expressed transcript selection -- Differentiation detection in microarray normalization -- Preprocessing and normalization for Affymetrix GeneChip expression microarrays -- Spatial detrending and normalization methods for two-channel DNA and protein microarray data -- A survey of cDNA microarray normalization and a comparison by k-NN classification -- Technical variation in modeling the joint expression of several genes -- Biological interpretation for microarray normalization selection -- Methodology of functional analysis for omics data normalization -- Exon array analysis for the detection of alternative splicing -- Normalization of array CGH data -- SNP array-based analysis for the detection of chromosomal aberrations and copy number variations.
  • Digital
    Bengt Nölting.
    Digital : Springer2006
    The three-dimensional structure of proteins. -- Liquid chromatography of biomolecules. -- Mass spectrometry. -- X-ray structural analysis. -- Protein infrared spectroscopy. -- Electron microscopy. -- Scanning probe microscopy. -- Biophysical nanotechnology. -- Proteomics: high throughput protein functional analysis. -- Ion mobility spectrometry. -- Ø-value analysis. -- Evolutionary computer programming. -- Conclusions.
  • Digital
    Turksen, Kursad; Walker, John M.
    Digital : Springer Protocolsv. 1-, 1984-
  • Digital
    Walker, John M.
    Digital : Springer Protocolsv. 1-142, 1996-2008.
  • Digital
    edited by Vicente Andres, Beatriz Dorado.
    Digital : Springer Protocols2015
    Use of mouse models in atherosclerosis research / Godfrey S. Getz and Catherine A. Reardon -- Cytokines and immune responses in murine atherosclerosis / Pascal J. H. Kusters and Esther Lutgens -- Intravital microscopy for atherosclerosis research / Remco T. A. Megens and Oliver Soehnlein -- Noninvasive molecular imaging of mouse atherosclerosis / Martina A. McAteer and Robin P. Choudhury -- Oil red O and hematoxylin and eosin staining for quantification of atherosclerosis burden in mouse aorta and aortic root / M. Jesús Andrés-Manzano, Vicente Andrés, and Beatriz Dorado -- Isolation, culture, and polarization of murine bone marrow-derived and peritoneal macrophages / Inés Pineda-Torra ... [et al.] -- Isolation of mouse primary aortic endothelial cells by selection with specific antibodies / Pedro Molina-Sánchez and Vicente Andrés -- Isolation and culture of aortic smooth muscle cells and in vitro calcification assay / Ricardo Villa-Bellosta and Magda R. Hamczyk -- Immunostaining of macrophages, endothelial cells, and smooth muscle cells in the atherosclerotic mouse aorta / Prashanthi Menon and Edward A. Fisher -- Immunostaining of lymphocytes in mouse atherosclerotic plaque / Anton Gisterå and Daniel F. J. Ketelhuth -- Flow cytometric analysis of immune cells within murine aorta / Breanne N. Gjurich, Parésa L. Taghavie-Moghadam, and Elena V. Galkina -- In vitro differentiation of naïve CD4+ T cells : a tool for understanding the development of atherosclerosis / Salvador Iborra and Jose M. González-Granado -- Quantification of apoptosis in mouse atherosclerotic lesions / Nichola L. Figg and Martin R. Bennett -- Quantification of cellular proliferation in mouse atherosclerotic lesions / José J. Fuster -- Quantification of in vitro macrophage cholesterol efflux and in vivo macrophage-specific reverse cholesterol transport / Joan Carles Escolà-Gil ... [et al.] -- In vitro macrophage phagocytosis assay / Magda R. Hamczyk, Ricardo Villa-Bellosta, and Vicente Andrés -- Glucose and insulin tolerance tests in the mouse / Ángela Vinué and Herminia González-Navarro -- Wire myography to study vascular tone and vascular structure of isolated mouse arteries / Lara del Campo and Mercedes Ferrer -- Pressure myography to study the function and structure of isolated small arteries / Olav L. Schjørring, Rune Carlsson, and Ulf Simonsen -- Generation of aorta transcript atlases of wild-type and apolipoprotein E-null mice by laser capture microdissection-rased mRNA expression microarrays / Changjun Yin ... [et al.] -- Analysis of gene and protein expression in atherosclerotic mouse aorta by western blot and quantitative real-time PCR / José Rivera-Torres -- Bone marrow transplantation in mice to study the role of hematopoietic cells in atherosclerosis / Vinatha Sreeramkumar and Andrés Hidalgo -- Tandem stenosis to induce atherosclerotic plaque instability in the mouse / Yung Chih Chen, Jennifer Rivera, and Karlheinz Peter -- Detection of intraplaque hemorrhage in mouse atherosclerotic lesions / Judith C. Sluimer, Marion J. Gijbels, and Sylvia Heeneman -- Mechanical stabilization of mouse carotid artery for in vivo intravital microscopy imaging of atherogenesis / Raphaël Chèvre -- Intravital microscopy in the cremaster muscle microcirculation for endothelial dysfunction studies / Cristina Rius and María J. Sanz -- Fluorescent molecular tomography for in vivo imaging of mouse atherosclerosis / Alicia Arranz ... [et al.] -- In vivo 18F-FDG-PET imaging in mouse atherosclerosis / Jesús Mateo ... [et al.] -- Magnetic resonance imaging of the atherosclerotic mouse aorta / Jesús Mateo ... [et al.].
  • Digital
    edited by Bhanu P. Jena.
    Digital : ScienceDirect2008
    Print2008
  • Digital
    edited by Amy E. Keating.
    Digital : ScienceDirect2013
    Computational design of novel protein binders and experimental affinity maturation -- Mining tertiary structural motifs for assessment of designability -- Computational methods for controlling binding specificity -- Flexible backbone sampling methods to model and design protein alternative conformations -- Osprey: protein design with ensembles, flexibility, and provable algorithms -- Scientific benchmarks for guiding macromolecular energy function improvement -- Molecular dynamics simulations for the ranking, evaluation, and refinement of computationally designed proteins -- Multistate protein design using CLEVER and CLASSY -- Using analyses of amino acid coevolution to understand protein structure and function -- Evolution-based design of proteins -- Protein engineering and stabilization from sequence statistics: variation and covariation analysis -- Enzyme engineering by targeted libraries -- Generation of high-performance binding proteins for pepetide motifs by affinity clamping -- Engineering fibronectin-based binding proteins by yeast surface display -- Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing -- Efficient sampling of SCHEMA chimera families to identify useful sequence elements -- Protein switch engineering by domain insertion -- Design of chimeric proteins by combination of subdomain-sized fragments -- [alpha]-helix mimicry with [alpha/beta]-peptides.
  • Digital
    edited by Daniel Jameson, Malkhey Verma, and Hans V. Westerhoff.
    Digital : ScienceDirect2011
    Print2011
  • Digital
    edited by Ormond A. Macdougald.
    Digital : ScienceDirectpt. A-B, 2014.
    Digital : ScienceDirectpt. B
  • Digital
    edited by W. Jeffrey Hurst.
    Digital : CRCnetBASE2008
    Phytoestrogens / B. Dave Oomah and Farah S. Hosseinian -- Analysis of fatty acids in functional foods with emphasis on [omega] 3 fatty acids and conjugated linoleic acid / Gary Dobson -- Analysis of flavonoids in functional foods and nutraceuticals / Laura Bravo and Raquel Mateos -- Exploitation of residues from vineyards, olive groves, and wine and oil production to obtain phenolic compounds of high-added value / María D. Luque de Castro, José M. Luque-Rodríguez, and Rafael Japón-Luján -- Anthocyanins / Gary Takeoka and Lan Dao -- Carotenoids and provitamin A in functional foods / María Isabel Mí́nguez-Mosquera, Dámaso Hornero-Méndez, and Antonio Pérez-Gálvez -- Chlorophylls / María Isabel Mí́nguez-Mosquera ... [et al.] -- Water-soluble vitamins / Míguel Ángel Fernández-Muiño, María Teresa Sancho-Ortiz, and Felicidad Valls-García -- Amino acid analysis / Larry R. Massom -- Carbohydrates and other electrochemically active compounds in functional foods / William R. LaCourse.
  • Digital
    edited by Jerry J. Buccafusco.
    Digital : CRCnetBASE2009
    DSU Title III 2002-2012.
  • Digital
    Suhail A. R. Doi, Gail M. Williams, editors.
    Digital : Springer2013
    "Methods of Clinical Epidemiology" serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level textbook of clinical epidemiology methodology. This book will be of use to postgraduate students in clinical epidemiology as well as clinical researchers at the start of their careers.
  • Digital
    Digital : Springerv. 4-5, 2005-07.
    Digital : Springerv. 5 (2007)
  • Digital
    Alexander A. Morgan.
    Digital2011
    The acquisition of biomedical research data is continually expanding, both in the number of variables measured in any single experiment and the number of experiments being done. To bring the fruits of all this labor into medical practice, we need to develop techniques for integrating high dimensional assays across experimental studies. In this thesis, I develop and demonstrate several approaches to multiplex meta-analysis, the synthesis multiple of high dimensional studies. I discuss the development of an overall expression map, examining the properties of gene expression dynamics across thousands of studies. I use this analysis of gene expression dynamics to develop methods of integrating highly parallelized gene expression studies to both identify new biomarkers of disease process, and to prioritize genes likely to contribute to disease risk. Finally, I demonstrate a method for clinical genomics, integrating disease linked genetic variants across an entire genome for translation into medical practice.
  • Digital
    Louis Alexander Saddic, III.
    Digital2011
    The retinoblastoma tumor suppressor RB is a central cell cycle regulator. Here we demonstrate that RB can be methylated by SMYD2 at lysine 860, a highly conserved and novel site of modification. This methylation event occurs in vitro and in cells and is regulated during cell cycle progression, cellular differentiation, and in response to DNA damage. Furthermore, we show that RB mono-methylation at lysine 860 provides a direct binding site for the methyl-binding domain of the transcriptional repressor L3MBTL1. This modification may be crucial for regulating the function of RB as a tumor suppressor. Inactivation of RB and activation of the MYC family of oncogenes are frequent events in a large spectrum of human cancers. Here, we sought to also test whether loss of RB function would affect cancer development in a mouse model of c-MYC-induced hepatocellular carcinoma (HCC). We found that RB inactivation has minimal effects on the cell cycle, cell death, and differentiation features of liver tumors driven by increased levels of c-MYC. However, combined loss of RB and activation of c-MYC led to an increase in polyploidy in mature hepatocytes before the development of tumors and a trend for decreased survival after cancer initiation.
  • Digital
    Sandra Ceccatelli, Michael Aschner, editors.
    Digital : Springer2012
    Annotation Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHgs accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This bookwill provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
  • Digital
    Bertil B. Fredholm, editor.
    Digital : Springer2011
    Notes on the History of Caffeine Use / Bertil B. Fredholm -- Distribution, Biosynthesis and Catabolism of Methylxanthines in Plants / Hiroshi Ashihara, Misako Kato and Alan Crozier -- Pharmacokinetics and Metabolism of Natural Methylxanthines in Animal and Man / Maurice J. Arnaud -- Inhibition of Cyclic Nucleotide Phosphodiesterases by Methylxanthines and Related Compounds / Sharron H. Francis, Konjeti R. Sekhar, Hengming Ke and Jackie D. Corbin -- Methylxanthines and Ryanodine Receptor Channels / Serge Guerreiro, Marc Marien and Patrick P. Michel -- Xanthines as Adenosine Receptor Antagonists / Christa E. Müller and Kenneth A. Jacobson -- Theobromine and the Pharmacology of Cocoa / Hendrik Jan Smit -- Propentofylline: Glial Modulation, Neuroprotection, and Alleviation of Chronic Pain / Sarah Sweitzer and Joyce De Leo -- Methylxanthines, Seizures, and Excitotoxicity / Detlev Boison -- Impacts of Methylxanthines and Adenosine Receptors on Neurodegeneration: Human and Experimental Studies / Jiang-Fan Chen and Yijuang Chern -- Methylxanthines and Pain / Jana Sawynok -- Methylxanthines and Sleep / Tarja Porkka-Heiskanen -- Methylxanthines and Reproduction / Alba Minelli and Ilaria Bellezza -- Methylxanthines During Pregnancy and Early Postnatal Life / Ulrika Ådén -- Methylxanthines and the Kidney / Hartmut Osswald and Jürgen Schnermann -- The Cardiovascular Effects of Methylxanthines / Niels P. Riksen, Paul Smits and Gerard A. Rongen -- Methylxanthines in Asthma / Stephen L. Tilley -- Methylxanthines and Inflammatory Cells / György Haskó and Bruce Cronstein -- Methylxanthines, Inflammation, and Cancer: Fundamental Mechanisms / Akio Ohta and Michail Sitkovsky -- Methylxanthines and Drug Dependence: A Focus on Interactions with Substances of Abuse / Micaela Morelli and Nicola Simola -- Methylxanthines and Human Health: Epidemiological and Experimental Evidence / Marie-Soleil Beaudoin and Terry E. Graham.
  • Digital
    Morton A. Meyers, Chusilp Charnsangavej, Michael Oliphant.
    Digital : Springer2011
    A new paradigm -- Clinical embryology of the abdomen -- Clinical anatomy of the abdomen -- Mechanisms of spread of disease in the abdomen and pelvis -- Intraperitoneal spread of infections and seeded metastases -- The extraperitoneal spaces: normal and pathologic anatomy -- The extraperitoneal pelvic compartments -- Patterns of spread of disease from the liver -- Patterns of spread of disease from the distal esophagus and stomach -- Patterns of spread of disease from the pancreas -- Patterns of spread of disease from the small intestine -- Patterns of spread of disease from the large intestine -- Patterns of spread of renal, upper urothelial, and adrenal pathology -- Patterns of spread of disease of the pelvis and male urogenital organs -- Patterns of spread of gynecologic disease -- Patterns of extraabdominal and extrapelvic spread -- Internal abdominal hernias.
  • Digital
    editor-in-chief: Jeffrey K. Aronson.
    Digital : ClinicalKey2017
  • Digital
    [edited by Hanna K. Gaggin, James L. Januzzi].
    Digital : Springer2014
    Preparing for the cardiology board examination is an intensely stressful period and traditionally relies on the participant searching through their own references, whether that be the large textbooks, small handbooks and their own notes. Good books are generally too long and time-consuming, while shorter books are either insubstantial in content or rely too much on the views of one author. The key elements for a successful reference for those taking their boards are a balanced proportion of essential content alongside rare but frequently tested topics, the wisdom of experts in the field, a practical questions session at the end of every topic and additional visuals not possible on the two-dimensional page. In the MGH Cardiology Board Review, the Editors have compiled the expertise of over 72 experienced authors from the Mass General in a succinct volume, applying methods thoroughly tested in the Board Review Conference. In addition, two very important sections are included on ECGs and images, contents of which are derived from the board examination answer keys, the very ones that readers are expected to know. Plans on how to best approach the board examination preparation and what additional resources to go to are provided. In short, this book has all the strengths to ensure your success on the boards exam.
  • Digital
    [edited by] Warren S. Sandberg, Richard D. Urman, Jesse M. Ehrenfeld.
    Digital : ClinicalKey2011
    1. Anesthesia equipment and patient safety / Arna Banerjee, L. Jane Easdown, and Matthew B. Weinger -- 2. Medical gases: properties, supply, and removal / Jesse M. Ehrenfeld and Michael Oleyar -- 3. Anesthesia machine: a practical overview / Jeffrey M. Feldmann -- 4. Principles and practices of closed circuit anesthesia / Robert S. Holzman and Rebecca Lintner -- 5. Manual and mechanical ventilators / Demet Suleymanci, Robert M. Kacmarek, and Yandong Jiang -- 6. Supraglottic airway devices / Jordan L. Newmark and Warren S. Sandberg -- 7. Intubation equipment / Zhongcong Xie, Ali Diba, and Zhipeng Xu -- 8. Endotracheal airway devices / Young K. Ahn and Warren S. Sandberg -- 9. Noninvasive physiological monitors / Jordan L. Newmark and Warren S. Sandberg -- 10. Invasive hemodynamic monitoring / Beverly J. Newhouse and Rafael Montecino -- 11. Transesophageal echocardiography / Jacob Kaczmarski and Sugantha Sundar -- 12. Depth of anesthesia monitoring: principles and applications / Roy Esaki and George Mashour -- 13. Alarms in clinical anesthesia / F. Jacob Seagull and Richard P. Dutton -- 14. Equipment for regional anesthesia and acute pain management / Reuben Slater and Lisa Warren -- 15. Ultrasound for regional anesthesia and vascular access / Lisa Warren and Reuben Slater -- 16. Intravenous therapy, fluid delivery systems for resuscitation, and cell salvage devices / Vanessa G. Henke and Warren S. Sandberg -- 17. Drug infusion pumps in anesthesia, critical care, and pain management / Nathaniel Sims ... [et al.] -- 18. Devices for cardiac support / Michael G. Fitzsimons, Stephanie Ennis, and Thomas MacGillivray -- 19. Patient warming devices / Jennifer A. Chatburn and Warren S. Sandberg -- 20. Point-of-care testing in the operating room / Marianna P. Crowley -- 21. Anesthesia information management systems / Sachin Kheterpal -- 22. Pediatric considerations / Rebecca N. Lintner and Robert S. Holzman -- 23. Anesthesia equipment outside of the operating room / Sergio D. Bergese, Erika G. Puente, and Gilat Zisman -- 24. Provision of anesthesia in difficult situations and the developing world / Deborah J. Harris ... [et al.] -- 25. Prevention of infection: disinfection and sterilization of equipment / Arnold J. Berry -- 26. Legal and regulatory issues / Eric T. Pierce -- 27. Physical principles / Paul D. Davis -- 28. Basic physics of electricity / Paul D. Davis -- 29. Operating room electrical, fire, laser, and radiation safety / Anuja K. Antony, Chunbai Zhang, and William G. Austen -- 30. Neuroanesthesia equipment in the intraoperative setting / Sergio D. Bergese, Gilat Zisman, and Erika G. Puente.
  • Digital
    Natalia Aptsiauri, Angel Miguel Garcia-Lora, Teresa Cabrera.
    Digital : Springer2013
    Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • Digital
    Michael John Strohman.
    Digital2013
    B cells internalize antigen bound to membrane immunoglobulin and load antigen-derived peptides onto MHC class II proteins. How these pathways intersect is not well understood. We found that HLA-DM, a catalyst for peptide loading onto MHC class II, regulates immunoglobulin levels in human B cells and co-precipitates with immunoglobulin. In intact cells, HLA-DM and immunoglobulin are found in close proximity, and these complexes are in post-Golgi compartments. In vitro, in the endosomal pH range, the luminal domain of soluble HLA-DM (sDM) directly and specifically interacts with the immunoglobulin Fab domain, and sDM increases the amount of antigen released from immune complexes. These observations support a model in which HLA-DM facilitates the hand-off of antigen from immunoglobulin to MHC class II.
  • Digital
    Mental Health Gap Action Programme, World Health Organization.
    Digital : WHO2010
    Print2010
    The mhGAP-IG has been developed through an intensive process of evidence review. A WHO Guideline Development Group of international experts conducted systematic reviews to develop evidence-based recommendations. The recommendations were then converted into clearly presented stepwise interventions and then circulated among a wider range of reviewers across the world to include all the diverse contributions. The mhGAP-IG is based on the mhGAP Guidelines on interventions for mental, neurological and substance use disorders (http:// www.who.int/mental_health/mhgap/evidence/en/). Both documents will be reviewed and updated in 5 years. Any revision and update before that will be made to the online version of the document.--(excerpt, p. 1).
  • Digital
    Database : NCBI Bookshelf
    This searchable database is a collection of in vivo molecular imaging agents developed for positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and optical imaging. MICAD, a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, is being developed by NCBI, the National Center for Biotechnology Information".
  • Digital
    Mohammad Niyaz Khan.
    Digital : CRCnetBASE2007
  • Digital
    edited by W.F. Bynum and Caroline Overy.
    Digital : PubMed Central2009
    Print2009
  • Digital
    Howard A. Brody, Zahra Meghani, Kimberley Greenwald,editors.
    Digital : Springer2009
  • Print
    editors, David L. Brown, Gregory H. Borschel, Benjamin Levi.
    Print2014
  • Digital
    edited by Jaime Castillo-León, Winnie Edith Svendsen, Maria Dimaki.
    Digital : CRCnetBASE2012
    Interfacing biological material with micro- and nanodevices / Jaime Castillo-León and Winnie E. Svendsen -- Atomic force microscopy for liquid applications / Zachary James Davis -- Manipulation by electrical fields / Maria Dimaki -- Optical manipulation techniques / Kirstine Berg-Sørensen -- Ultrasonic manipulation techniques / Stefano Oberti and Jürg Dual -- 3D biomanipulation using microgrippers / Peter Bøggild -- Magnetic manipulation of biological structures / Maria Dimaki and Winnie E. Svendsen -- Microfluidic manipulation of biological samples / Fridolin Okkels.
  • Digital
    edited by Murugan Ramalingam, Esmaiel Jabbari, Seeram Ramakrishna, and Ali Khadembosseini.
    Digital : Wiley2013
    Digital2013
    Stem cells and nanotechnology in tissue engineering and regenerative medicine / Rocky Tuan -- Nanofiber technology for controlling stem cell functions and tissue engineering / Seeram Ramakrishna, Shayanti Mukherjee -- Micro- and nanoengineering approaches to developing gradient biomaterials suitable for interface tissue engineering / Ali Khademhosseini, Serge Ostrovidov -- Microengineered polymer and ceramic-based biomaterial scaffolds : a topical review on design, processing, and biocompatibility properties / Bikramjit Basu, Garima Tripathi -- Synthetic enroutes to engineer electrospun scaffolds for stem cells and tissue regeneration / Seeram Ramakrishna, Radhakrishnan Sridhar -- Integrating top-down and bottom-up scaffolding tissue engineering approach for bone regeneration / Esmaiel Jabbari, Yunzhi Yang -- Characterization of the adhesive interactions between cells and biomaterials / John Fisher -- Microfluidic formation of cell-laden hydrogel modules for tissue engineering / Shoji Takeuchi, Yuya Morimoto -- Micro- and nanospheres for tissue engineering / John Jansen -- Micro and nano technologies to engineer bone regeneration / Balaji Sitharaman -- Micro and nanotechnology for vascular tissue engineering / Laura Suggs -- Application of stem cells in ischemic heart disease / Gangapatnam Subrahmanyam, Ravi Shankar.
  • Digital
    Itai Bab, Carmit Hajbi-Yonissi, Yankel Gabet, Ralph Müller.
    Digital : Springer2007
  • Digital
    edited by Jonathan R. Pollack.
    Digital : Springer2009
    Print2009
    DNA microarray technology. Introduction / J.R. Pollack -- Comparative genomic hybridization on BAC arrays / B.P. Coe ... [et al.] -- Comparative genomic hybridization on spotted oligonucleotide microarrays / Y.H. Kim and J.R. Pollack -- Comparative genomic hybridization by representational oligonucleotide microarray analysis / R. Lucito and J. Byrnes -- Application of oligonucleotides arrays for coincident comparative genomic hybridization, ploidy status and loss of heterozygosity studies in human cancers / J.K. Cowell and K.C. Lo -- Molecular inversion probe assay for allelic quantitation / H. Ji and K. Welch -- A whole-genome amplification protocol for a wide variety of DNAs, including those from formalin-fixed and paraffin-embedded tissue / P.L. Paris -- Algorithms for calling gains and losses in array CGH data / P. Wang -- Methylation analysis by microarray / D.E. Deatherage ... [et al.] -- Methylation analysis by DNA immunoprecipitation (MeDIP) / E.A. Vucic ... [et al.] -- Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies / J. Eeckhoute, M. Lupien and M. Brown -- ChIP-Chip: algorithms for calling binding sites / X.S. Liu and C.A. Meyer -- Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip) / Y. Shibata and G.E. Crawford -- Microarray analysis of DNA replication timing / N. Karnani, C.M. Taylor and A. Dutta -- Integration of diverse microarray data types / K. Salari and J.R. Pollack.
  • Digital
    edited by Michael J. Korenberg.
    Digital : Springer Protocols2007
  • Digital
    Karl Fraser, Zidong Wang, Xiaohui Liu.
    Digital : CRCnetBASE2010
  • Digital
    edited by Luis Rueda.
    Digital : CRCnetBASE2014
    Microarray Image and Data Analysis: Theory and Practice is a compilation of the latest and greatest microarray image and data analysis methods from the multidisciplinary international research community. Delivering a detailed discussion of the biological aspects and applications of microarrays, the book:Describes the key stages of image processing, gridding, segmentation, compression, quantification, and normalizationFeatures cutting-edge approaches to clustering, biclustering, and the reconstruction of regulatory networksCovers different ty.
  • Digital
    [edited by] Robert S. Matson.
    Digital : CRCnetBASE2009
    Introduction to microarray technologies / Robert S. Matson -- Nucleic acid sample preparation / Robert S. Matson -- Solid-phase substrates for nucleic acid microarrays / Robert S. Matson -- Protein sample preparation for microarrays / Robert S. Matson -- Solid-phase chemistries for protein microarrays / Robert S. Matson -- Protein microarrays : the link between genomics and proteomics / Persis P. Wadia and David B. Miklos -- Bead arrays : an introduction to multiplexed bead-based assays for proteins / Yong Song -- Carbohydrate arrays / Denong Wang -- Lectin microarrays / Masao Yamada -- Printing methods / Todd Martinsky.
  • Digital
    edited by Simone Mocellin.
    Digital : Springer2006
    Print2006
    Manufacturing of microarrays -- Technological platforms for microarray gene expression profiling -- Principles of gene microarray data analysis -- Gaining weights ... and feeling good about it! -- Complementary techniques -- Microarrays for cancer diagnosis and classification -- Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy -- Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs -- SNP and mutation analysis -- Cancer development and progression -- Gene expression profiling in malignant lymphomas -- Tumor immunology.
  • Digital
    edited by Jang B. Rampal.
    Digital : Springer Protocolsv. 1-2, 2007.
    Digital : Springer Protocolsv.2, 2009
    v. 1. Synthesis methods -- v. 2. Applications and data analysis.
  • Digital
    edited by Thomas O. Joos, Paolo Fortina.
    Digital : Springer Protocols2005
    Print2005
  • Digital
    Bertrand Jordan, editor.
    Digital : Springer2012
    Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards nanoarrays, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
  • Digital
    Andreas Bosio, Bernhard Gerstmayer, editors.
    Digital : Springer2008
    Print2008
  • Digital
    Prakash S. Bisen, Mousumi Debnath, Godavarthi B.K.S. Prasad.
    Digital : Wiley2012
  • Digital
    G.N. Cohen.
    Digital : Springer2011
    Bacterial growth -- The outer membrane of gram-negative bacteria and the cytoplasmic membrane -- Peptidoglycan synthesis and cell division -- Cellular permeability -- Allosteric enzymes -- Glycolysis, gluconeogenesis and glycogen synthesis -- The pentose phosphate and Entner-Doudoroff pathways -- The tricarboxylic acid cycle and the glyoxylate bypass -- ATP-generating processes : respiration and fermentation -- Biosynthesis of lipids -- Iron-sulfur proteins -- The archaea -- Methanogens and methylotrophs -- Enzyme induction in catabolic systems -- Transcription : RNA polymerase -- Negative regulation -- Enzyme repression in anabolic pathways -- Positive regulation -- The ribosomes -- The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases -- Attenuation -- Riboswitches -- The biological fixation of nitrogen -- How biosynthetic pathways have been established -- The aspartic acid family of amino acids : biosynthesis -- Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae -- Other patterns of regulation of the synthesis of amino acids of the aspartate family -- Biosynthesis of the amino acids of the glutamic acid family and its regulation -- Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid -- Selenocysteine and selenoproteins -- Biosynthesis of aromatic amino acids and its regulation -- The biosynthesis of histidine and its regulation -- The biosynthesis of nucleotides -- The biosynthesis of deoxyribonucleotides -- Biosynthesis of some water-soluble vitamins and of their coenzyme forms -- Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones -- Biosynthesis of the tetrapyrrole ring system -- Biosynthesis of cobalamins including vitamin B12 -- Interactions between proteins and DNA -- Evolution of biosynthetic pathways.
  • Digital
    edited by Gianfranco Donelli.
    Digital : Springer Protocols2014
    Methods for dynamic investigations of surface-attached in vitro bacterial and fungal biofilms / Claus Sternberg, Thomas Bjarnsholt, and Mark Shirtliff -- Aqueous two-phase system technology for patterning bacterial communities and biofilms / Mohammed Dwidar, Shuichi Takayama, and Robert J. Mitchell -- Quorum sensing in gram-positive bacteria : assay protocols for Staphylococcal agr and Enterococcal fsr systems / Akane Shojima and Jiro Nakayama -- Advanced techniques for in situ analysis of the biofilm matrix (structure, composition, dynamics) by means of laser scanning microscopy / Thomas R. Neu and John R. Lawrence -- Multiplex fluorescence in situ hybridization (M-FISH) and confocal laser scanning microscopy (CLSM) to analyze multispecies oral biofilms / Lamprini Karygianni, Elmar Hellwig, and Ali Al-Ahmad -- Field emission scanning electron microscopy of biofilm-growing bacteria Involved in nosocomial infections / Claudia Vuotto and Gianfranco Donelli -- Experimental approaches to investigating the vaginal biofilm microbiome / Marc M. Baum, Manjula Gunawardana, and Paul Webster -- Imaging bacteria and biofilms on hardware and periprosthetic tissue in orthopedic infections / Laura Nistico, Luanne Hall-Stoodley, and Paul Stoodley -- Animal models to evaluate bacterial biofilm development / Kim Thomsen, Hannah Trøstrup, and Claus Moser -- Animal models to investigate fungal biofilm formation / Jyotsna Chandra, Eric Pearlman, and Mahmoud A. Ghannoum -- Nonmammalian model systems to investigate fungal biofilms / Marios Arvanitis ... [et al.] -- Microbiological methods for target-oriented screening of biofilm inhibitors / Livia Leoni and Paolo Landini -- In vitro screening of antifungal compounds able to counteract biofilm development / Marion Girardot and Christine Imbert -- Biofilm matrix-degrading enzymes / Jeffrey B. Kaplan -- Efficacy evaluation of antimicrobial drug-releasing polymer matrices / Iolanda Francolini, Antonella Piozzi, and Gianfranco Donelli -- Antibiotic polymeric nanoparticles for biofilm-associated infection therapy / Wean Sin Cheow and Kunn Hadinoto -- Pharmacokinetics and pharmacodynamics of antibiotics in biofilm infections of Pseudomonas aeruginosa in vitro and in vivo / Wang Hengzhuang, Niels Høiby, and Oana Ciofu -- Contribution of confocal laser scanning microscopy in deciphering biofilm tridimensional structure and reactivity / Arnaud Bridier and Romain Briandet -- Chip calorimetry for evaluation of biofilm treatment with biocides, antibiotics, and biological agents / Frida Mariana Morais, Friederike Buchholz, and Thomas Maskow -- Bacteriophage attack as an anti-biofilm strategy / Sanna Sillankorva and Joana Azeredo -- Photodynamic therapy as a novel antimicrobial strategy against biofilm-based nosocomial infections : study protocols / Francesco Giuliani -- Capturing air-water interface biofilms for microscopy and molecular analysis / Margaret C. Henk -- Biofilm-growing bacteria involved in the corrosion of concrete wastewater pipes : protocols for comparative metagenomic analyses/ Vicente Gomez-Alvarez -- Culture-independent methods to study subaerial biofilm growing on biodeteriorated surfaces of stone cultural heritage and frescoes / Francesca Cappitelli, Federica Villa, and Andrea Polo -- Biofilms of thermophilic bacilli isolated from dairy processing plants and efficacy of sanitizers / Sara A. Burgess, Denise Lindsay, and Steve H. Flint.
  • Digital
    edited by José-Luis Barredo.
    Digital : Springer Protocols2012
    Pathways of carotenoid biosynthesis in bacteria and microalgae / J. Paniagua-Michel, Jorge Olmos-Soto, and Manuel Acosta Ruiz -- Selection and taxonomic identification of carotenoid-producing marine actinomycetes / Francisco Romero -- Isolation, characterization, and diversity of novel radiotolerant carotenoid-producing bacteria / Dalal Asker [and others] -- Novel radio-tolerant astaxanthin-producing bacterium reveals a new astaxanthin derivative : astaxanthin dirhamnoside / Dalal Asker [and others] -- Novel zeaxanthin-producing bacteria isolated from a radioactive hot spring water / Dalal Asker [and others] -- Novel approach in the biosynthesis of functional carotenoids in Escherichia coli / Hisashi Harada and Norihiko Misawa -- Engineering Escherichia coli for canthaxanthin and ataxanthin biosynthesis / Qiong Cheng and Luan Tao -- Analysis of canthaxanthin production by Gordonia jacobaea / Patricia Veiga-Crespo [and others] -- Isolation and light-stimulated expression of canthaxanthin and spirilloxanthin biosynthesis genes from the photosynthetic bacterium Bradyrhizobium sp. Strain ORS278 / Eric Giraud and Andre Vermeglio -- Construction of carotenoid biosynthetic pathways through chromosomal integration in methane-utilizing bacterium Methylomonas sp. strain 16a / Rick W. Ye and Kristen Kelly -- Genetic modification in Bacillus subtilis for production of C30 carotenoids / Isamu Maeda -- Carotenoids' production from halophilic bacteria / Maria de Lourdes Moreno [and others] -- Construction and utilization of carotenoid reporter systems : identification of chromosomal integration sites that support suitable expression of biosynthetic genes and pathways / Pamela L. Sharpe and Deana J. DiCosimo -- Directed evolution of carotenoid synthases for the production of unnatural carotenoids / Maiko Furubayashi and Daisuke Umeno -- High-Throughput Screen for the Identi fi cation of improved catalytic activity: b-carotene hydroxylase / Mark A. Scaife [and others] -- DNA fingerprinting intron-sizing method to accomplish a specific, rapid, and sensitive identification of carotenogenic Dunaliella species / Jorge Olmos-Soto [and others] -- Ketocarotenoid biosynthesis in transgenic microalgae expressing a foreign beta-C-4-carotene oxygenase gene / Marta Vila [and others] -- Characterization of carotenogenesis genes in the cyanobacterium Anabaena sp. PCC 7120 / Hajime Masukawa, Mari Mochimaru, and Shinichi Takaichi -- Obtaining lutein-rich extract from microalgal biomass at preparative scale / Jose M. Fernandez-Sevilla, F. Gabriel Acien Fernandez, and Emilio Molina Grima -- NMR-based isotopologue profiling of microbial carotenoids / Eva Eylert, Adelbert Bacher, and Wolfgang Eisenreich -- Analysis of diapocarotenoids found in pigmented Bacillus species / Laura Perez-Fons and Paul D. Fraser.
  • Digital
    edited by José-Luis Barredo.
    Digital : Springer Protocols2012
  • Digital
    editor, Vladimir Krcméry.
    Digital : Future Med2013
    Antibiotic resistance : postantibiotic era is here / Vladimir Krcmery -- Current challenges in treating methicillin-resistant Staphylococcus aureus : what are the options? / Noha E.I. Sakka & Ian M . Gould -- Antimicrobial-resistant Streptococcus pneumoniae : trends and management / Michael R. Jacobs -- Emergence and management of drug-resistant enterococcal infections / William R. Miller, Barbara E. Murray & Cesar A. Arias -- Enterobacteriaceae that produce newer b-lactamases / Johann D.D. Pitout -- Extensively drug-resistant tuberculosis : new strains, new challenges / Megan Coffee -- Clinical significance of extended-spectrum b-lactamases / Jesés Rodréguez-Baño, Belén Gutiérrez, Lorena Lépez-Cerero & Alvaro Pascual -- Plasmid-mediated quinolone resistance / José Manuel Rodréguez-Marténez, Maréa Eliecer Cano, Jorge Calvo, Álvaro Pascual & Luis Marténez-Marténez -- Antibiotic resistance in the absence of antimicrobial use / Lucia Pallecchi, Alessandro Bartoloni, Eduardo Gotuzzo & Gian Maria Rossolini -- Resistance in bacteria of the food chain : epidemiology and control strategies / Lina Maria Cavaco & Frank Møller Aarestrup -- Measures to prevent antimicrobial resistance / Vhairi M. Bateman & Ian M. Gould -- Where does novel antibiotics R&D stand among other pharmaceutical products? / Glenn S. Tillotson -- Resistance to antiretroviral drugs / Manuela Colafigli, Simona Di Giambenedetto & Roberto Cauda -- Index.
  • Digital
    Miling Yan.
    Digital2012
    The establishment and wide acceptance of an abundant and diverse human-associated microbial community has been one of the most important shifts in the field of microbiology in the past decade. From a bacterial perspective, the body is a vast landscape whose shifting geography and fluctuating environmental conditions provide a range of distinct residential possibilities. Some habitats, such as the intestinal tract and the oral cavity, have been characterized more extensively than others; within these environs, an understanding of the interplay between microbial ecology and health and disease has begun to emerge. The nasal cavity, a crucial component of both the respiratory system and innate immune system, has yet to benefit from an exploration of similar depth. Recent examination of the nasal microbial habitat has almost exclusively focused on the anterior nares without examining deeper sites within the cavity which are actively involved in nasal mucociliary clearance and exposed to the efflux of various sinuses. The aim of this work was to explore this biogeography by characterizing the microbial communities in a range of spatial sites along the nasal passageway. Additionally, the nasal cavity has long been a source of pathogens, most notably Staphylococcus aureus. Carriage of S. aureus has been demonstrated to be a significant risk factor for acquisition of antibiotic resistant strains of S. aureus and hospital-acquired infections. The second aim of this project was to understand whether underlying community features may be present that were characteristic of S. aureus carriage. 13 healthy subjects (6 persistent and 7 non-persistent carriers) were sampled weekly at 3 different sites (anterior nares, middle meatus, and sphenoethmoidal recess) within the nasal cavity over a 4-week period. The data shows that biogeographical differences were based less upon spatial factors and more on epithelium type. The data also showed that the S. aureus carriage type of the individual contributed the greatest amount of non-S. aureus variation within the communities. Finally, a carriage-classifying model was generated from the data and examined for important predictive features, revealing a potential intra-genus, interspecific competitive interaction in Corynebacterium with implications on S. aureus carriage. These results highlight the complexity present in human microbial communities even within highly spatially constrained microenvironments.
  • Digital
    Mark Lyte, Primrose P.E. Freestone, editors.
    Digital : Springer2010
  • Digital
    editor, Mark Lyte.
    Digital : Springer2016
    Print2016
    Microbial Endocrinology: An Ongoing Personal Journey -- New Trends and Perspectives in Evolutionary Considerations of Neurotransmitters in Microbial, Plant and Animal Cells -- Catecholamine-directed Epithelial Cell Interactions With Bacteria in the Intestinal Mucosa -- Modulation of the Interaction of Enteric Bacteria with Intestinal Mucosa -- Dietary Catechols and their Relationship to Microbial Endocrinology -- Mechanisms by Which Catecholamines Induce Growth in Gram-Negative and Gram-Positive Human Pathogens -- Molecular Profiling: Catecholamine Modulation of Gene Expression in Escherichia coli O157:H7 and Salmonella enterica serovar Typhimurium -- Microbial Endocrinology of Pseudomonas aeruginosa -- Interkingdom Chemical Signaling in Enterohemorrhagic Escherichia coli O157:H7 -- Role of Microbial Endocrinology in Periodontal Disease -- Staphylococci, Catecholamine Inotropes and Hospital-Acquired Infections -- Experimental Design Considerations for In Vitro Microbial -- The Role of the Microbiome in the Relationship of Asthma and Affective Disorders -- Psychological Stress, Immunity and Effects on Indigenous Flora -- Microbiome to Brain: Unraveling the Multidirectional Axes of Communication -- Mycologic Endocrinology.
  • Digital
    Mark Lyte, John F. Cryan, editors.
    Digital : Springer2014
    Print2014
    "The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host ("us"). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease"--Publisher's description.
  • Digital
    edited by Charles L. Wilson.
    Digital : CRCnetBASE2008
    Preface: Food--A Necessity and a Threat -- Editor -- Contributors -- Section I. Instances and Nature of Microbial Food Contamination -- 1. PulseNet and Emerging Foodborne Diseases / Efrain M. Ribot, Eija Hyytia-Trees, and Kara Cooper -- 2. Pathogenic Mechanisms of the Enterohemorrhagic
  • Digital
    edited by Andrei L. Osterman, Svetlana Y. Gerdes.
    Digital : Springer Protocols2008
    Overview of whole-genome essentiality analysis / Karen Joy Shaw -- Pt. I. Experimental protocols. IA. Populational genome-wide essentiality screens. Transposon-based strategies for the identification of essential bacterial genes / William S. Reznikoff and Kelly M. Winterberg -- Identification and analysis of essential genes in Haemophilus influenzae / Sandy M.S. Wong and Brian J. Akerley -- Transposon site hybridization in Mycobacterium tuberculosis / Jeffrey P. Murry ... [et al.] -- Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis / François Sanschagrin, Irena Kukavica-Ibrulj, and Roger C. Levesque -- Whole-genome detection of conditionally essential and dispensable genes in Escherichia coli via genetic footprinting / Michael D. Scholle and Svetlana Y. Gerdes -- Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis / Taeok Bae ... [et al.] -- Multipurpose transposon insertion libraries for large-scale analysis of gene function in yeast / Anuj Kumar -- IB. Systematic collections of knockout mutants. How to make a defined near-saturation mutant library. Case 1: Pseudomonas aeruginosa PAO1 / Michael A. Jacobs -- Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality / Nicole T. Liberati ... [et al.] -- The construction of systematic in-frame, single-gene knockout mutant collection in Escherichia coli K-12 / Tomoya Baba and Hirotada Mori -- The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12 / Tomoya Baba ... [et al.] -- A novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12 / Takeyoshi Miki, Yoshihiro Yamamoto, and Hideo Matsuda -- High-throughput creation of a whole-genome collection of yeast knockout strains / Angela M. Chu and Ronald W. Davis -- Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray / Pamela B. Meluh ... [et al.] -- IC. Genome minimization. Scarless engineering of the Escherichia coli genome / Tamás Fehér ... [et al.] -- Minimization of the Escherichia coli genome using the Tn5-targeted Cre/loxP excision system / Byung Jo Yu and Sun Chang Kim -- Construction of long chromosomal deletion mutants of Escherichia coli and minimization of the genome / Jun-ichi Kato and Masayuki Hashimoto -- ID. Conditional knockouts. Identification of essential genes in Staphylococcus aureus by construction and screening of conditional mutant library / Dezhong Yin and Yinduo Ji -- Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus / Allyn Forsyth and Liangsu Wang -- Introduction of conditional lethal amber mutations in Escherichia coli / Christopher D. Herring -- Pt. II. Bioinformatics. IIA. Statistics. Statistical methods for building random transposon mutagenesis libraries / Oliver Will -- Statistical evaluation of genetic footprinting data / Gábor Balázsi -- Modeling competitive outgrowth of mutant populations : why do essentiality screens yield divergent results? / Alexander I. Grenov and Svetlana Y. Gerdes -- Statistical analysis of fitness data determined by TAG hybridization on microarrays / Brian D. Peyser, Rafael Irizarry, and Forrest A. Spencer -- IIB. Data integration and modeling. Profiling of Escherichia coli chromosome database / Yukiko Yamazaki, Hironori Niki, and Jun-ichi Kato -- Gene essentiality analysis based on DEG, a database of essential genes / Chun-Ting Zhang and Ren Zhang -- Detection of essential genes in Streptococcus pneumoniae using bioinformatics and allelic replacement mutagenesis / Jae-Hoon Song and Kwan Soo Ko -- Design and application of genome-scale reconstructed metabolic models / Isabel Rocha, Jochen Förster, and Jens Nielsen -- Predicting gene essentiality using genome-scale in silico models / Andrew R. Joyce and Bernhard Ø. Palsson -- Comparative approach to analysis of gene essentiality / Andrei L. Osterman and Svetlana Y. Gerdes.
  • Digital
    [edited by] Thomas J. Dougherty, Steven J. Projan.
    Digital : CRCnetBASE2003
    Print2003
  • Digital
    editor-in-chief, Anthony P. Moran ; editors, Otto Holst, Patrick J. Brennan, Mark von Itzstein.
    Digital : ScienceDirect2009
  • Digital
    edited by Ron J. Doyle.
    Digital : ScienceDirect2001
    Print2001
  • Digital
    edited by Ron J. Doyle.
    Digital : ScienceDirect2001
    Print2001
  • Digital
    editors, Per Brandtzaeg, Erika Isolauri, Susan L. Prescott.
    Digital : Karger2009
    A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- "ABC" of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. ... [et al.] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. ... [et al.] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. ... [et al.] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A.
  • Digital
    edited by Tor Savidge and Charalabos Pothoulakis.
    Digital : ScienceDirect2005
    Print2005
  • Digital
    volume editors: Friedhelm Meinhardt, Roland Klassen.
    Digital : Springer2007
  • Digital
    edited by Qiong Cheng.
    Digital : Springer Protocols2012
    Screening for cellulases with industrial value and their use in biomass conversion / Julia Jüergensen, Nele Ilmberger, and Wolfgang R. Streit -- Reversal of NAD(P)H cofactor dependence by protein engineering / Sabine Bastian and Frances H. Arnold -- Quantifying plasmid copy number to investigate plasmid dosage effects associated with directed protein evolution / Samuel Million-Weaver [and others] -- High isoprenoid flux Escherichia coli as a host for carotenoids production / Wonchul Suh -- Mutagenic inverted repeats assisted genome engineering (MIRAGE) in Saccharomyces cerevisiae : deletion of gal7 / Nikhil U. Nair and Huimin Zhao -- Creation of new metabolic pathways or improvement of existing metabolic enzymes by in vivo evolution in Escherichia coli / Isabelle Meynial-Salles and Philippe Soucaille -- Bioluminescent reporter genes for promoter discovery / Tina K. Van Dyk -- Recombination-based DNA assembly and mutagenesis methods for metabolic engineering / Xiquan Liang [and others] -- Ethanol-tolerant gene identification in Clostridium thermocellum using pyro-resequencing for metabolic engineering / Shihui Yang, Dawn M. Klingeman, and Steven D. Brown -- Use of proteomic tools in microbial engineering for biofuel production / Shaoming Mao [and others] -- Metabolic engineering of antibiotic-producing Actinomycetes using in vitro transposon mutagenesis / Andrew R. Reeves and J. Mark Weber -- Use FACS sorting in metabolic engineering of Escherichia coli for increased peptide production / Qiong Cheng [and others] -- Using flux balance analysis to guide microbial metabolic engineering / Kathleen A. Curran, Nathan C. Crook, and Hal S. Alper -- Using an advanced microfermentor system for strain screening and fermentation optimization / Dongming Xie -- Rapid strain evaluation using dynamic DO-stat fed-batch fermentation under scale-down conditions / Jun Sun -- Preparation and evaluation of lignocellulosic biomass hydrolysates for growth by ethanologenic yeasts / Ying Zha [and others] -- Engineering whole-cell biosensors with no antibiotic markers for monitoring aromatic compounds in the environment / Aitor de las Heras and Víctor de Lorenzo -- Metabolic engineering for acetate control in large scale fermentation / Yong Tao, Qiong Cheng, and Alexander D. Kopatsis -- Minimization and prevention of phage infections in bioprocesses / Marcin Los.
  • Digital
    edited by Edward F. DeLong.
    Digital : ScienceDirect2013
    This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers microbial metagenomics, metatranscriptomics, and metaproteomics, and includes chapters on such topics as in-solution FISH for single cell genome preparation, preparation of BAC libraries from marine microbial community DNA, and preparation of microbial community cDNA for metatranscriptomic analysis in marine plankton. Continues the legacy of this premier serial with quality chapters authored by leaders in the field.
  • Print
    edited by Uday Kishore, Annapurna Nayak.
    Print2013
    "The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti-viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus-airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens"--Publisher's description.
  • Digital
    volume editors, Hilde de Reuse, Stefan Bereswill.
    Digital : Karger2009.
    Genome comparison of bacterial pathogens / Wassenaar, T.M. ... [et al.] -- In silico reconstruction of the metabolic and pathogenic potential of bacterial genomes using subsystems / McNeil, L.K., Aziz, R.K. -- The bacterial pan-genome and reverse vaccinology / Tettelin, H. -- 'Guilty by association' : protein-protein interactions (PPIS) in bacterial pathogens / Schauer, K., Stingl, K -- Helicobacter pylori sequences reflect past human migrations / Moodley, Y., Linz, B. -- Helicobacter pylori genome plasticity / Baltrus, D.A., Blaser, M.A., Guillemin, K. -- Genomics of Thermophilic campylobacter species / Gaskin, D.J.H. ... [et al.] -- Adaptation of pathogenic E. coli to various niches : genome flexibility is the key / Brzuszkiewicz, E. ... [et al.] -- Role of horizontal gene transfer in the evolution of Pseudomonas aeruginosa virulence / Qiu, X., Kulasekara, B.R., Lory, S. -- The genus Burkholderia : analysis of 56 genomic sequences / Ussery, D.W. ... [et al.] -- Genomics of host-restricted pathogens of the genus Bartonella / Engel, P., Dehio, C. -- Legionella pneumophila - host interactions : insights gained from comparative genomics and cell biology / Lomma, M. ... [et al.] -- A proteomics view of virulence factors of Staphylococcus aureus / Engelmann, S., Hecker, M. -- Pathogenomics of mycobacteria / Gutierrez, M.C., Supply, P., Brosch, R.
  • Digital
    [edited by] Ian Humphery-Smith, Michael Hecker.
    Digital : Wiley2006
    Print2006
    "Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed."--Publisher's website.
  • Digital
    edited by Ipek Kurtböke.
    Digital : ScienceDirect2017
    Planctomycetes : new models for microbial cells and activities / John A. Fuerst -- A flavor of prokaryotic taxonomy : systematics revisited / Paul De Vos, Fabiano Thompson, Cristiane Thompson and Jean Swings -- Bioactive actinomycetes : reaching rarity through sound understanding of selective culture and molecular diversity / Ipek Kurböke -- Microbial resources for global sustainability / Jim Philp and Ronald Atlas -- Modern natural products drug discovery and its relevance to biodiversity conservation / C. Benjamin Naman, Christopher A. Leber and William H. Gerwick -- Hydrocarbon-oxidizing bacteria and their potential in eco-biotechnology and bioremediation / Irena B. Ivshina, Maria S. Kuyukina and Anastasiya V. Krivoruchko -- An overview of the industrial aspects of antibiotic discovery / Evan Martens and Arnold L. Demain -- Accessing marine microbial diversity for drug discovery/ Lynette Bueno Pérez and William Fenical -- Cryptic pathways and implications for novel drug discovery / Kozo Ochi -- The Nagoya protocol applied to microbial genetic resources / Philippe Desmeth -- Fungal genetic resources for biotechnology / Kevin McCluskey -- Industrial culture collections : gateways from microbial diversity to applications / Olga Genilloud -- An overview of biological resource center-maintenance of microbial resources and their management / Ken-ichiro Suzuki -- IP and the Budapest Treaty : depositing biological material for patent purposes / Vera Bussas, Avinash Sharma and Yogesh Shouche -- Biosafety, transport, and related legislation concerning microbial resources : an overview / Vera Bussas.
  • Digital
    Ajit Varma, Sudhir Chincholkar (eds.).
    Digital : Springer2007
  • Digital
    Charles Hagedorn, Anicet R. Blanch, Valerie J. Harwood, editors.
    Digital : Springer2011
    Chapter 1: Overview -- Chapter 2: Performance Criteria -- Chapter 3: Library-dependent Source Tracking Methods -- Chapter 4: Library-Independent Source Tracking Methods -- Chapter 5: Viruses as Tracers of Fecal Contamination -- Chapter 6: Phage Methods -- Chapter 7: Pathogenic Protozoa -- Chapter 8: Chemical-Based Fecal Source Tracking Methods -- Chapter 9: Statistical Approaches for Modeling in Microbial Source Tracking -- Chapter 10: Mitochondrial DNA as Source Tracking Markers of Fecal Contamination -- Chapter 11: Community Analysis-Based Methods -- Chapter 12: Public Perception of and Public Participation in Microbial Source Tracking -- Chapter 13: Use of Microbial Source Tracking in the Legal Arena: Benefits and Challenges -- Chapter 14: Applications of Microbial Source Tracking in the TMDL Process -- Chapter 15: Relating MST Results to Fecal Indicator Bacteria, Pathogens, and Standards -- Chapter 16: Minimizing Microbial Source Tracking at All Costs -- Chapter 17: Environmental Persistence and Naturalization of Fecal Indicator Organisms -- Chapter 18: Agricultural and Rural Watersheds -- Chapter 19: Case Studies of Urban and Suburban Watersheds -- Chapter 20: Beaches and Coastal Environmenta -- Chapter 21: Source tracking in Australia and New Zealand: Case Studies -- Chapter 22: Microbial Source Tracking in China and Developing Nations -- Chapter 23: A National Security Perspective of Microbial Source Tracking -- Chapter 24: Applications of Quantitative Microbial Source Tracking (QMST) and Quantitative Microbial Risk Assessment (QMRA) -- Chapter 25: Food Safety and Implications for Microbial Source Tracking -- Chapter 26: Training Future Scientists: Teaching Microbial Source Tracking (MST) to Undergraduates -- Index.
  • Digital
    Christiane Dahl, Cornelius G. Friedrich (editors).
    Digital : Springer2008
    Genetics and genomics of sulfate respiration in desulfovibrio / Judy D. Wall ... [et al.] -- Living on sulfate : three-dimensional structure and spectroscopy of adenosine 5'-phosphosulfate reductase and dissimilatory sulfite reductase / Günter Fritz ... [et al.] -- Respiratory membrane complexes of Desulfovibrio / Inês A. Cardoso Pereira -- Biochemical and evolutionary aspects of eukaryotes that inhabit sulfidic environments / Ursula Theissen, William Martin -- Evolution and ecology of microbes dissimilating sulfur compounds : insights from siroheme sulfite reductases / Alexander Loy, Stephan Duller, Michael Wagner -- Genomic and evolutionary perspectives on sulfur metabolism in green sulfur bacteria / Niels-Ulrik Frigaard, Donald A. Bryant -- Differential-expression proteomics for the study of sulfur metabolism in the chemolithoautotrophic Acidithiobacillus ferrooxidans / Lissette Valenzuela ... [et al.] -- Sulfur and light? History and "thiology" of the phototrophic sulfur bacteria / Hans G. Trüper -- Thiosulfate and sulfur oxidation in purple sulfur bacteria / Frauke Grimm, Bettina Franz, Christiane Dahl -- Sulfur oxidation in Chlorobium tepidum (syn. Chlorobaculum tepidum) : genetic and proteomic analyses / Leong-Keat Chan, Rachael Morgan-Kiss, Thomas E. Hanson -- Structural insights into component SoxY of the thiosulfate-oxidizing multienzyme system of Chlorobaculum thiosulfatiphilum / Jan Stout ... [et al.] -- Redox control of chemotrophic sulfur oxidation of Paracoccus pantotrophus / Cornelius G. Friedrich ... [et al.] -- Bacterial sulfite-oxidizing enzymes : enzymes for chemolithotrophs only? / Ulrike Kappler -- Sulfonates and organotrophic sulfite metabolism / Alasdair M. Cook, Theo H.M. Smits, Karin Denger -- Oxidation of sulfur and inorganic sulfur compounds in Acidianus ambivalens / Arnulf Kletzin -- A novel coenzyme F420 dependent sulfite reductase and a small sulfite reductase in methanogenic archaea / Eric F. Johnson, Biswarup Mukhopadhyay -- Archaeal and bacterial sulfur oxygenase-reductases : genetic diversity and physiological function / Shuang-Jiang Liu -- Diversity of halophilic sulfur-oxidizing bacteria in hypersaline habitats / Dimitry Y. Sorokin -- Sulfur oxidation at deep-sea hydrothermal vents / Stefan M. Sievert ... [et al.] -- Speciation analysis of microbiologically produced sulfur by X-ray absorption near edge structure spectroscopy / Alexander Prange -- Controls on isotope fractionation during dissimilatory sulfate reduction / Joost Hoek, Donald E. Canfield -- Bioprocess engineering of sulfate reduction for environmental technology / Piet N.L. Lens ...[et al.] -- Impact of nitrate on the sulfur cycle in oil fields / Gerrit Voordouw.
  • Digital
    edited by Colin Harwood, Anil Wipat.
    Digital : ScienceDirect2013
    Computational intelligence in the design of synthetic microbial genetic systems / Jennifer S. Hallinan -- Constraints in the design of the synthetic bacterial chassis / Antoine Danchin and Agnieszka Sekowska -- Social dimensions of microbial synthetic biology / Jane Calvert, Emma Frow -- Bacillus subtilis: model gram-positive synthetic biology chassis / Colin R. Harwood, Suzanne Pohl, Wendy Smith, Anil Wipat -- Engineering microbial biosensors / Lisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont, Karen Polizzi -- Noise and stochasticity in gene expression: a pathogenic fate determinant / Mikkel Girke Jørgensen, Renske van Raaphorst, Jan-Willem Veening -- Platforms for genetic design automation / Chris J. Myers.
  • Digital
    edited by Ali Navid.
    Digital : Springer Protocols2012
    pt. I. Sample preparation and identification. -- 1. Flow cytometry in environmental microbiology: a rapid approach for the isolation of single cells for advanced molecular biology analysis / Belinda C. Ferrari, Tristrom J. Winsley, Peter L. Bergquist, and Josie Van Dorst ; 2. Pressure cycling technology in systems biology / Bradford S. Powell, Alexander V. Lazarev, Greta Carlson, Alexander R. Ivanov, and David A. Rozak ; 3. Targeted isolation of proteins from natural microbial communities living in an extreme environment / Steven W. Singer ; 4. Bacterial identification and subtyping using DNA microarray and DNA sequencing / Sufian F. Al-Khaldi, Magdi M. Mossoba, Marc M. Allard, E. Kurt Lienau, and Eric D. Brown -- pt. II. Experimental genomic analysis. -- 5. Genetic manipulation of the obligate chemolithoautotrophic bacterium Thiobacillus denitrificans / Harry R. Beller, Tina C. Legler, and Stacie R. Kane ; 6. Genome-wide mapping of the binding sites of proteins that interact with DNA / Stephen Spiro -- pt. III. Protein and lipid analysis. -- 7. Microbial proteomics using mass spectrometry / Harry B. Hines ; 8. Fourier transform infrared spectroscopy for molecular analysis of microbial cells / Jesús J. Ojeda and Maria Dittrich -- pt. IV. Metabolomic analyses. -- 9. Mass spectrometery-based microbial metabolomics / Edward E.K. Baidoo, Peter I. Benke, and Jay D. Keasling ; 10. Fast sampling of the cellular metabolome / Walter M. Van Gulik, Andre B. Canelas, Hilal Taymaz-Nikeel, Rutger D. Douma, Lodewijk P. de Jonge, and Joseph J. Heijnen -- pt. V. -- 11. Metabolic pathway determination and flux analysis in nonmodel microorganisms through 13C-isotope labeling / Xueyang Feng, Wei-Qin Zhuang, Peter Colletti, and Yinjie J. Tang ; 12. Biolog phenotype microarrays / April Shea, Mark Wolcott, Simon Daefler, and David A. Rozak ; 13. NanoSIP: nanoSIMS applications for microbial biology / Jennifer Pett-Ridge and Peter K. Weber -- pt. VI. Kinetic modeling of cellular processes -- 14. Electrophysiological-metabolic modeling of microbes: applications in fuel cells and environment analysis / Max Fontus and Peter Ortoleva ; 15. Simulating microbial systems: addressing model uncertainty/incompleteness via multiscale and entropy methods / A. Singharoy, H. Joshi, S. Cheluvaraja, Y. Miao, D. Brown, and P. Ortoleva -- pt. VII. -- 16. Bacterial genome annotation / Nicholas Beckloff, Shawn Starkenburg, Tracey Freitas, and Patrick Chain ; 17. LeishCyc: a guide to building a metabolic pathway database and visualization of metabolomic data / Eleanor C. Saunders, James I. MacRae, Thomas Naderer, Milica Ng, Malcolm J. McConville, and Vladimir A. Likić ; 18. Development of constraint-based system-level models of microbial metabolism / Ali Navid ; 19. Complex network analysis in microbial systems: theory and examples / Zahra Zavareh and Eivind Almaas ; 20. Modeling a minimal cell / Michael L. Shuler, Patricia Foley, and Jordan Atlas.
  • Digital
    edited by Otto Holst.
    Digital : Springer Protocols2011
    Part I: Bacterial protein toxins -- Detection of bacterial protein toxins by solid phase magnetic immunocapture and mass spectrometry / Gabriella Pocsfalvi and Gitta Schlosser -- Sensitive and rapid detection of cholera toxin-producing Vibrio cholerae using loop-mediated isothermal amplification / Wataru Yamazaki -- Ultrasensitive detection of botulinum neurotoxins and anthrax lethal factor in biological samples by ALISSA / Karine Bagramyan and Markus Kalkum -- Examination of Bacillus anthracis spores by multiparameter flow cytometry / William C. Schumacher [and others] -- A cell-based fluorescent assay to detect the activity of shiga toxin and other toxins that inhibit protein synthesis / Shane Massey, Beatriz Quiñones, and Ken Teter -- Use of a vero cell-based fluorescent assay to assess relative toxicities of shiga toxin 2 subtypes from Escherichia coli / Beatriz Quiñones and Michelle S. Swimley -- Molecular methods: chip assay and quantitative real-time PCR: in detecting hepatotoxic cyanobacteria / Anne Rantala-Ylinen, Hanna Sipari, and Kaarina Sivonen -- Part II: Endotoxins -- Capillary electrophoresis chips for fingerprinting endotoxin chemotypes from whole-cell lysates / Béla Kocsis [and others] -- Isolation of smooth-type lipopolysaccharides to electrophoretic homogeneity / Elder Pupo -- A method for unobtrusive labeling of lipopolysaccharides with quantum dots / Carlos Morales-Betanzos, Maria Gonzalez-Moa, and Sergei A. Svarovsky -- Fluorescence-based methods to assay inhibitors of lipopolysaccharide synthesis / Marcy Hernick -- Micromethods for lipid a isolation and structural characterization / Martine Caroff and Alexey Novikov -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. I. LPS activation with cyanogen bromide / Fernando Battaglini and Diego Pallarola -- Two efficient methods for the conjugation of smooth-form lipopolysaccharides with probes bearing hydrazine or amino groups. II. LPS activation with a cyanopyridinium agent / Fernando Battaglini and Diego Pallarola -- Part III: Mold fungus toxins -- Extraction and analysis of fumonisins and compounds indicative of fumonisin exposure in plant and mammalian tissues and cultured cells / Nicholas C. Zitomer and Ronald T. Riley -- Determination of fumonisins B1 and B2 in maize food products by a new analytical method based on high-performance liquid chromatography and fluorimetric detection with post-column derivatization / Marilena Muscarella [and others] -- A confirmatory method for aflatoxin M1 determination in milk based on immunoaffinity cleanup and high-performance liquid chromatography with fluorometric detection / Marilena Muscarella [and others] -- Simultaneous determination of aflatoxins B1, B2, G1, and G2 in foods and feed materials / Marilena Muscarella [and others] -- Highly sensitive PCR-based detection specific to Aspergillus flavus / Amaia González-Salgado -- A rapid enzymatic method for aflatoxin B detection / Danila Moscone, Fabiana Arduini, and Aziz Amine.
  • Digital
    edited by Sidney Harshman.
    Digital : ScienceDirect1988
    Print1988
  • Digital
    Zdenek Hubálek, Ivo Rudolf.
    Digital : Springer2011
    Type of human disease by source of the infectious agent -- A history of zoonoses and sapronoses and research into them -- The infection process in zoonoses and sapronoses -- The epidemic process in zoonoses and sapronoses -- Haematophagous arthropods as vectors of diseases -- Vertebrates as hosts and reservoirs of zoonotic microbial agents -- Systematic survey of zoonoses and sapronoses microbial agents.
  • Digital
    Jeremy Nuttall, editor.
    Digital : Springer2014
    One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
  • Print
    Print2008
    Status: Not Checked OutLane Catalog Record
    Problems linked with pathogens in fresh produce, including the associated public health and trade implications, have been reported in a number of countries worldwide. Furthermore, from 1980 to 2004, the global production per annum of fruit and vegetables grew by 94% and they are a critical component of a healthy diet. Reported outbreaks associated with leafy vegetables and herbs have been notable for the wide geographical distribution of the contaminated products, the high numbers of consumers exposed and thus the large number of cases. This meeting addressed the pathways for contamination, survival and persistence of microbiological hazards associated with leafy vegetables and herbs, and the potential management options from primary production through to the consumer.--Publisher's description.
  • Print
    Todd A. Swanson, Sandra I. Kim, Olga E. Flomin.
    Status: Not Checked OutLane Catalog Record
    v. 1. Virology, immunology, parasitology, mycology -- v. 2. Bacteriology.
  • Print
    James D. Kettering.
    Print2010
    Status: Not Checked OutLane Catalog Record
  • Print
    [edited by] Matthew B. Grisham.
    Print2014
    Status: Not Checked OutLane Catalog Record
    High Yield Facts -- Physiology and Molecular Microbiology -- Virology -- Bacteriology -- Rickettsiae, Chlamydiae, and Mycoplasms -- Mycology -- Parasitology -- Immunology.
  • Print
    James D. Kettering, Hansel M. Fletcher, Craig A. Seheult.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Digital
    Steven L. Percival, editor.
    Digital : Springer2009
  • Digital
    Digital : Springerv. 1-, 2006-
  • Digital
    Patrice Dion, Chandra Shekhar Nautiyal, editors ; foreword by John D. Rummel.
    Digital : Springer2008
  • Digital
    Steven L. Percival, Marylynn V. Yates, David W. Williams, Rachel M. Chalmers, Nicholas F. Gray.
    Digital : ScienceDirect2014
    The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus. Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen. Contains new material on antimicrobial resistance and biofilms. Covers drinking water and both marine and freshwater recreational bathing waters.
  • Digital
    edited by Steven Percival and Keith Cutting.
    Digital : CRCnetBASE2010
    An introduction to the world of microbiology and biofilmology / Steven L. Percival, John G. Thomas, and David Williams -- Human skin and microbial flora / Rose A. Cooper and Steven L. Percival -- An introduction to wounds / Michel H.E. Hermans and Terry Treadwell -- Burn wound management / Michel H.E. Hermans -- Cell biology of normal and impaired healing / Keith Moore -- The microbiology of wounds / Steven L. Percival and Scott E. Dowd -- Types of wounds and infections / Randall D. Wolcott ... [et al.] -- Biofilms and significance to wound healing / Keith F. Cutting ... [et al.] -- Wounds, enzymes, and proteases / Steven L. Percival and Christine A. Cochrane -- Wound healing immunology and biofilms / Emma J. Woods ... [et al.] -- Antimicrobial interventions for wounds / Steven L. Percival, Rose A. Cooper, and Benjamin A. Lipsky -- Wound dressings and other topical treatment modalities in bioburden control / Richard White -- Factors affecting the healing of chronic wounds : an iconoclastic view / Marissa J. Carter and Caroline E. Fife.
  • Print
    S. James Booth.
    Print2010
    Status: Not Checked OutLane Catalog Record
    Basic bacteriology -- Genetics -- Antimicrobial agents -- General medical microbiology -- Gram-positive cocci -- Gram-negative cocci -- Gram-positive and acid-fast bacilli -- Gram-negative bacilli -- Anaerobes -- Spirochetes -- Atypical pathogenic bacteria : mycoplasma, rickettsia, ehrlichia, anaplasma, chlamydia, and chlamydophila -- Virology -- Mycology -- Parasitology -- Random pearls.
  • Digital
    edited by Martin H. Floch, Yehuda Ringel, W. Allan Walker.
    Digital : ScienceDirect2017
  • Digital
    Andreas Schwiertz, editor.
    Digital : Springer2016
    Print2016
    Preface -- Chapter 1. Microbiota: what does it mean (historic considerations- Schwiertz et. al) -- Chapter 2. Studying the human microbiota -- Alan Walker -- Chapter 3. The gut microbiota and their metabolites: potential implications for the host epigenome -- Mona Mischke and Torsten Plösch -- Chapter 4. The Oral Microbiota -- Nicole B. Arweiler, Lutz Netuschil -- Chapter 5. Skin Microbiota -- Markus Egert and Rainer Simmering -- Chapter 6. Vaginal Microbiota -- Werner Mendling -- Chapter 7. Gastrointestinal Microbiota -- Hermie J.M. Harmsen and Marcus. C. de Goffau -- Chapter 8. How to manipulate the Microbiota by Probiotics -- Verena Grimm and Christian U. Riedel -- Chapter 9. How to manipulate the Microbiota by Prebiotics -- Petra Louis, Harry J. Flint and Catherine Michel. Chapter 10. Microbiota transplantation -- Susana Fuentes, Ph.D. and Willem M. de Vos, Prof. Ph.D -- Index. .
  • Digital
    edited by Pierre N. Floriano.
    Digital : Springer Protocols2007
    Microchip electrophoresis for DNA separation by wire-imprinted microchannels on PMMA substrates / Shu-Hui Chen -- Fabrication of porous polymer monoliths in microfluidic chips for selective nucleic acid concentration and purification / Jay A.A. West and Brent C. Satterfield -- Rapid electrical lysis of bacterial cells in a microfluidic device / Hsiang-Yu Wang ... [et al.] -- On-chip bioassay using immobilized sensing bacteria in three-dimensional microfluidic network / Hirofumi Tani, Koji Maehana, and Tamio Kamidate -- Microchip-based enumeration of human white blood cells / Pierre Floriano ... [et al.] -- Microchip for the diagnosis of cervical cancer / Anja Gulliksen and Frank Karlsen -- DNA microchips toward molecular signatures in cervical cancers / Yick F. Wong ... [et al.] -- Impedimetric detection for DNA hybridization within microfluidic biochips / Louise Lingerfelt ... [et al.] -- Applications of functional protein microarrays: identifying protein/protein interactions in an array format / Matthew A. Coleman ... [et al.] -- A microchip-based assay for interleukin-6 / Nicolaos Christodoulides ... [et al.] -- Allergen microarrays for the diagnosis of specific IgE against components of cow milk and hen egg in a multiplex biochip-based immunoassay / Christian Harwanegg, Sabine Hutter, and Reinhard Hiller -- Surface plasmon resonance imaging on polypyrrole protein chips: application to streptavidin immobilization and immunodetection / Emilie Mercey ... [et al.] -- Protein array-based multiplexed cytokine assays / Cheng C. Wang -- Lectin microarrays for glycoprotein analysis / Lara K. Mahal and Kanoelani Pilobello -- Interaction of HIV RNA with peptides detected by acoustic shear wave sensor operated in an on-line format / Anil Deisingh ... [et al.] -- Microchip-based electrochemical enzyme immunoassays / Madhu Prakash Chatrathi, Greg Collins, and Joseph Wang.
  • Digital
    edited by Charles S. Henry.
    Digital : Springer Protocols2006
  • Digital
    edited by Ann Van Schpdael.
    Digital : Springer Protocols2015
    An overview of the use of microchips in electrophoretic separation techniques : fabrication, separation modes, sample preparation opportunities, and on-chip detection / Stijn Hendrickx, Wim de Malsche, and Deirdre Cabooter -- Microchip electrophoresis for fast and interference-free determination of trace amounts of glyphosate and glufosinate residues in agricultural products / Xuan Wei and Qiaosheng Pu -- Microchip capillary electrophoresis of nitrite and nitrate in cerebrospinal fluid / Marián Masár, Róbert Bodor, and Peter Troška -- Analysis of thiols by microchip capillary electrophoresis for in situ planetary investigations / Maria F. Mora, Amanda M. Stockton, and Peter A. Willis -- Analysis of ofloxacin in ofloxacin ear drops by microfluidic chip coupled with contactless conductivity detection / Bing Chen and Kaicheng Li -- Microchip capillary electrophoresis : quantum dots and paramagnetic particles for bacteria immunoseparation / Sona Krizkova [and 6 others] -- Fast high-throughput screening of H1N1 virus by parallel detection with multichannel microchip electrophoresis / Peng Zhang [and three others] -- Sex identification of ancient DNA samples using microfluidic device / Kristy J. Shaw [and three others] -- Fast and continuous-flow detection and separation of DNA complexes and DNA in nanofluidic chip format / Martina Viefhues, Jan Regtmeier, and Dario Anselmetti -- Multidimensional microchip-capillary electrophoresis device for determination of functional proteins in infant milk formula / Ruige Wu, Ahiping Wang, and Ying Sing Fung -- Fast assembly of anti-voltage photonic crystals in microfluidic channels for ultrafast separation of amino acids and peptides / Yi Chen, Tao Liao, and Can Hu -- Rapid determination of catecholamines in urine samples by nonaqueous microchip electrophoresis with LIF detection / Hongmei Hu, Yuanming Guo, and Tiejun Li -- Carbon nanotube-based separation columns for microchip electrochromatography / K. B. Mogensen, B. Delacourt, and J. P. Kutter -- Electrochromatography on acrylate-based monolith in cyclic olefin copolymer microchip : an attractive technology / Y. Ladner, G. Cretier, and K. Faure -- On-chip electromembrane extraction for monitoring drug metabolism in real time by electrospray ionization mass spectrometry / Nickolaj J. Petersen, Henrik Jensen, and Stig Pedersen-Bjergaard -- Sample preparation for N-glycosylation analysis of therapeutic monoclonal antibodies by electrophoresis / Ákos Szekrényes [and 5 others].
  • Digital
    edited by Ursula Bilitewski.
    Digital : Springer Protocols2009
    DNA microarrays: an introduction to the technology / Ursula Bilitewski -- Discussion of the applicability of microarrays: profiling of leukemias / Torsten Haferlach ... [et al.] -- Expression profiling using Affymetrix GeneChip microarrays / Herbert Auer, David L. Newsom, and Karl Kornacker -- Genotyping of mutation in the beta-globin gene using DNA microarrays / Martin Dufva and Lena Poulsen -- Antibody-based microarrays / Christer Wingren and Carl A.K. Borrebaeck -- Application of protein ArrayTubes to bacteria, toxin, and biological warfare agent detection / Ralf Ehricht ... [et al.] -- Detection of known allergen-specific IgE antibodies by immunological methods / Barbara I. Fall and Reinhard NieSner -- Peptide microarrays for serum antibody diagnostics / Heiko Andresen and Frank F. Bier -- Microchips for cell-based assays / Martin Dufva -- Bio-cell chip fabrication and applications / Honggu Chun, Dong Soon Lee, and Hee Chan Kim -- Microchip capillary electrophoresis / Elaine T.T. Tay ... [et al.] -- Detection of enteropathogenic Escherichia Coli by microship capillary electrophoresis / Wai S. Law, Sam F.Y. Li, and Larry J. Kricka.
  • Print
    edited by John Grayson and Walter Zingg.
    Status: Not Checked OutLane Catalog Record
    v. 1. Blood-vessel interactions -- v. 2. Microcirculation.
  • Digital
    edited by Martin J. Leahy.
    Digital : Wiley2012
  • Digital
    Tatsuhisa Takahashi.
    Digital : Springer2014
    This book presents a new method for analyzing the structure and function of the biological branching systems of fractal trees, with a focus on microcirculation. Branching systems in humans (vascular and bronchial trees) and those in the natural world (plants, trees, and rivers) are characterized by a fractal nature. To date, fractal studies have tended to concentrate on fractal dimensions, which quantify the complexity of objects, but the applications for practical use have remained largely unexplored. This book breaks new ground with topics that include the human retinal microcirculatory network, oxygen consumption by vascular walls, the Fh raeus-Lindqvist effect, the bifurcation exponent, and the asymmetrical microvascular network. Readers are provided with simple formulas to express functions and a simulation graph with in vivo data. The book also discusses the mechanisms regulating blood flow and pressure and how they are related to pathological changes in the human body. Researchers and clinicians alike will find valuable new insights in these pioneering studies.
  • Digital
    Markus Müller, editor.
    Digital : Springer2013
    In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970s, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
  • Digital
    edited by Giuseppe Di Giovanni, Vincenzo Di Matteo.
    Digital : Springer Protocols2013
    Cerebral microdialysis : research technique or clinical tool? / Anouk Borg and Martin Smith -- In vivo microdialysis to study striatal dopaminergic neurodegeneration / Giuseppe Di Giovanni [and others] -- Application of reverse microdialysis in neuropharmacological studies / Christian Hocht, Facundo Martin Bertera, and Carlos Alberto Taira -- Microdialysis and advances for sampling synaptic and extrasynaptic pools / Cheng-fu Chen [and others] -- In vivo microdialysis for measurement of oxidative metabolism in the living brain / H. Ronald Zielke, Carol L. Zielke, and Peter J. Baab -- Quantitative in vivo microdialysis in pharmacokinetic studies / Teodoro Zornoza [and others] -- Combination of in vivo microdialysis with selective electrochemical detection for online continuous monitoring of brain chemistry / Yuqing Lin, Zipin Zhang, and Lanqun Mao -- Application of spinal microdialysis in freely moving rats / Vincent Umbrain [and others] -- Monitoring extracellular monoamines with in vivo microdialysis in awake rats : a practical approach / Roberto W. Invernizzi -- Intracerebral Human Microdialysis in Parkinson's Disease / Salvatore Galati and Giuseppe Di Giovanni -- Monitoring extracellular amino acid neurotransmitters and hROS by in vivo microdialysis in rats : a practical approach / Maria Alessandra Colivicchi [and others] -- Measurement of neuropeptides in dialysate by LC-MS / Omar S. Mabrouk and Robert T. Kennedy -- Achieving high temporal resolution for in vivo measurements by microdialysis / Neil D. Hershey and Robert T. Kennedy -- Indirect analysis of nitric oxide and quantitation of selective nitric oxide synthase inhibitors in microdialysate samples / Gary M. Pollack -- Determination of histamine in microdialysis samples from the rodent brain by column liquid chromatography / Jan Kehr and Takashi Yoshitake -- Intracerebral microdialysis in the study of limbic seizure mechanisms and antiepileptic drug action using freely moving rats / Jeanelle Portelli and Ilse Smolders.
  • Digital
    edited by Stéphane Marinesco, Nicholas Dale.
    Digital : Springer Protocols2013
    Microelectrode designs for oxidase-based biosensors / Stephane Marinesco and Olivier Frey -- Microelectrode array fabrication and optimization for selective neurochemical detection / Kevin N. Hascup [and others] -- Advantage of microelectrode technologies for measurement in delicate biological environments such as brain tissue / Andrea Jaquins-Gerstl and Adrian C. Michael -- Hexacyanoferrates as mediators for microelectrode biosensors / Faming Tian and Nicholas Dale -- Enzyme immobilization on microelectrode biosensors / Natalia Vasylieva and Stephane Marinesco -- Characterization of polymer-enzyme composite biosensors for brain monitoring in vivo / Robert D. O'Neill -- Monitoring extracellular glutamate in the brain by microdialysis and microsensors / Si Qin [and others] -- Sub-second measurements of glutamate and other neurotransmitter signaling using enzyme-based ceramic microelectrode arrays / Erin R. Hascup [and others] -- Regulation of extracellular concentrations of D-serine in the central nervous system revealed by D-amino acid oxidase microelectrode biosensors / Pierre Pernot, Caroline Maucler, and Stephane Marinesco -- Measurement of purine release with microelectrode biosensors / Nicholas Dale -- Glucose and lactate monitoring across the rat sleep-wake cycle / Raymond Cespuglio, Larissa Netchiporouk, and Nataliya Shram -- Forebrain cholinergic systems and cognition : new insights based on rapid detection of choline spikes using enzyme-based biosensors / Vinay Parikh and Martin Sarter -- Carbon nanotubes-based microelectrode (bio)sensors / Paloma Yanez-Sedeno, Lourdes Agui, and Jose M. Pingarron -- Label-free affinity biosensors based on electrochemical impedance spectroscopy / Nicole Jaffrezic-Renault -- Aptamer-based electrochemical biosensors for the detection of small molecules and plasma proteins / Cassie Ho and Hua-Zhong Yu -- Electrochemiluminescent biosensors : neuroscience applications / Robert J. Forster and Tia E. Keyes -- Molecularly imprinted polymers : promising advanced materials for in vivo sensing / Yi Ge [and others].
  • Digital
    Christopher Michael Earhart.
    Digital2010
    Nanoscience and nanotechnology have been applied in recent years to cancer research, with the goal of bringing about a revolutionary change in the ways in which cancer is diagnosed and treated. Magnetic nanotechnologies, in particular, have shown significant potential in several areas, such as imaging, therapeutics, early detection, and point-of-care therapy monitoring. Most applications of magnetic nanotechnology in cancer research involve the use of nanoscale magnetic carriers. Depending on the properties of the particular carrier and the manner in which they are employed, magnetic carriers can act as MRI contrast enhancing agents, drug delivery vehicles, bio-labels for detection with magnetic biosensors, or selection agents in immunomagnetic separation platforms. The small sizes (10-100 nm), functional surface chemistries, and controllable magnetic responses of nanoscale magnetic carriers allows for interaction with and control of biological entities in both novel and powerful ways. The focus of this thesis is on a specific application of magnetic carriers -- magnetic separation of biomolecules and rare cells. After an introduction and an overview of magnetic separation principles are given in Chapters 1 and 2, Chapters 3-6 discuss the design, fabrication, and use of a novel magnetic separation device, the magnetic sifter. The magnetic sifter is a microfabricated, 7 x 7 mm planar die containing a dense array of pores (~200-5000/mm^2) in a magnetically soft membrane. When magnetized by an external field, the sifter pores generate large magnetic field gradients (~10^6 T/m) near the pore edges, which can capture nanoscale magnetic carriers with high efficiency and throughput. The gradients can be turned off by removing the external field, and the magnetic carriers can be released. The magnetic sifter is a microfluidic device, in the sense that it contains microfabricated, micron-scale pores which generate large field gradients. It is also a macrofluidic device, in that high volume throughput is achieved by parallel flow through the dense array of pores. Magnetic modeling of the magnetic sifter and a method for its fabrication are presented in Chapters 3 and 4. When paired with magnetic carriers functionalized with recognition moieties, the magnetic sifter can be used in both protein and cell enrichment schemes. The focus of Chapter 5 is on using the magnetic sifter to capture individual magnetic nanoparticles. The intended application is for enrichment of cancer protein markers prior to detection with a magnetic spin-valve biosensor. High capture efficiencies (80-100%) of magnetic nanoparticles have been achieved for a single pass through the magnetic sifter. Magnetic nanoparticles can also be released from the magnetic sifter with nearly 100% efficiency. The focus of Chapter 6 is the use of the magnetic sifter for rare cell enrichment, for applications in enumeration and enrichment of circulating tumor cells. It is shown that the magnetic sifter can capture tumor cells from whole blood with high efficiency and throughput (~60% at 5 ml/hr). Furthermore, with its planar structure and presentation of captured cells, the magnetic sifter doubles as a cell imaging platform, allowing for identification and quantification with optical microscopy. In addition to its high capture efficiency and gentle release of captured cells, the small size and scalable fabrication of the magnetic sifter are attractive for applications in point-of-care cancer diagnostics for early detection and monitoring of metastatic disease. In Chapter 7, a method for high-throughput fabrication of novel magnetic carriers, synthetic antiferromagnetic (SAF) nanoparticles is presented. The method has enabled production of large quantities of SAF nanoparticles, which have desirable properties for applications in magnetic separation. The capture and release behavior of SAF nanoparticles with the magnetic sifter has been demonstrated. High capture efficiencies are achieved at flow rates 10-20x higher than what was previously possible with commercially available magnetic carriers. Both the magnetic sifter and physically fabricated SAF nanoparticles offer unique advantages over traditional technologies. They are each, in their own right, promising new technologies for applications in cancer detection and therapy monitoring.
  • Digital
    edited by Emilia Biffi.
    Digital : Springer Protocols2015
    Fabrication of microfluidic platforms with pneumatically/hydraulically controlled PDMS valves and their use in neurobiological research / Bryson M. Brewer, Donna J. Webb, and Deyu Li -- Reliable reversible bonding method for perfused microfluidic devices / Paola Occhetta, Emilia Biffi, and Marco Rasponi -- Bridging two cultures : minimalistic networks prepared by microfluidic arraying, and open access compartments for electrophysiology / Jonathan West ... [et al.] -- Asymmetric genetic manipulation and patch clamp recording of neurons in a microfluidic chip / Prasanna Sakha ... [et al.] -- Development of a compartmentalized biochip for axonal isolation and neuronal-circuit formation at the single-cell level / Ting Huang ... [et al.] -- Campenot cultures and microfluidics provide complementary platforms for spatial study of dorsal root ganglia neurons / Sara J. Fenstermacher, Maria F. Pazyra-Murphy, and Rosalind A. Segal -- Development of microfluidic devices for the manipulation of neuronal synapses / Anika Jain and Martha U. Gillette -- Use of a 3-compartment microfluidic device to study activity dependent synaptic competition / Ainsley Coquinco and Max Cynader -- Multi-compartment neuron-glia coculture microsystem / Jaewon Park ... [et al.] -- Compartmentalized microfluidic platforms as tool of choice to study the interaction between neurons and osteoblasts / Estrela Neto ... [et al.] -- Novel in vitro primary culture model of the lower motor neuron-neuromuscular junction circuit / Katherine A. Southam ... [et al.] -- Compartmentalized microfluidics for in vitro Alzheimer's disease studies / Yufei Ren, Anja Kunze, and Philippe Renaud -- Selective biochemical manipulation of twin neuronal networks on microelectrode arrays / Giulia Regalia ... [et al.] -- Compartmentalized synapse microarray for high- throughput screening / Amol D. Jadhav ... [et al.].
  • Digital
    Aaron Michael Streets.
    Digital2012
    Phase transitions are ubiquitous in nature. Fundamental study of phase transition phenomena is a cornerstone of condensed matter physics, and theoretical results in this area guide technology development in material science. Phase transitions also play an important role in biology. Biological macromolecule phase transitions occur in many biological processes, for example the gel-liquid transition in lipid bilayers and amyloid formation in protein aggregation disease. From a technological standpoint, the ability to crystallize proteins has enabled one of the most important advances in biology of the last century: protein structure determination with X-ray crystallography. However, biological macromolecule phase transitions often display stark phenomenological differences from their inorganic analogs. This owes to the sheer size and complexity of proteins and nucleic acid complexes. Macromolecular phase transition theory is rich in subtleties, anecdotal & counter-intuitive results, and often diverges from predictions of classical theory. In addition to developing theory, fundamental study in this area is also critical for improvements in high-throughput crystallography efforts and in understanding mechanisms of devastating neurodegenerative diseases. This thesis approaches the study of macromolecule phase transitions through the development of new measurement technology. In this work, spectroscopic and imaging techniques are combined with microfluidic systems to provide insight into three areas of macromolecule phase transitions. First, dynamic light scattering and microscopy are integrated onto a microfluidic platform to study and optimize protein crystallization. Additionally dynamic light scattering is combined with fluorescence spectroscopy to investigate amyloid fibril aggregation. Finally, a new technology is presented that demonstrates high-throughput mapping of macromolecule structure by integrating single-molecule fluorescence resonance energy transfer spectroscopy with a microfluidic mixing platform. This lab-on-a-chip platform enables examination of conformational transitions in nucleic acids in response to changes in the chemical and molecular environment in order to create a conformational "phase diagram". In addition to presenting new insight into the mechanism of protein crystallization and protein aggregation, this thesis introduces new technologies for studying biological macromolecule phase transitions.
  • Digital
    Angela Ruohao Wu.
    Digital2012
    Protein--DNA interactions are responsible for numerous critical cellular events: for example, gene expression and silencing are mediated by transcription factor protein binding and histone protein modifications, and DNA replication and repair rely on site specific protein binding. Chromatin immunoprecipitation (ChIP) is the only molecular assay that directly determines, in a living cell, the binding association between a protein of interest and specific genomic loci. It is an indispensible tool in the biologists' toolbox, but the many limitations of this technique prevent broad adoption of ChIP in biological studies. The typical ChIP assay can take up to one week to complete, and the process is technically tricky, yet tedious. ChIP assay yields are also low, thus requiring on the order of millions to billions of cells as starting material, which makes the assay unfeasible for studies on rare or precious samples. Cancer stem cells (CSCs), for instance, are obtained from primary tumors, and FACS sorting of the dissociated tumor cells rarely yields more than ~100,000 CSCs per tumor. This thesis describes the microfluidics-based strategies for performing ChIP. The first design for a microfluidic ChIP design utilizes the automation and scalability aspects of microfluidics to reduce both total and hands-on assay time, and improve throughput. It can take chromatin prepared using any existing ChIP protocol as input, and generate ChIP-qPCR results in just 1 day. The device is shown to be comparable to existing ChIP protocols, and can detect cellular epigenetic changes induced by external cytokine stimulants. It was used to investigate transcription factor binding dynamics in an aging-related pathway, and was able to link transcription factor binding to local changes in histone modifications. The second design of the microfluidic ChIP platform focuses on addressing the cell number requirements of ChIP. In addition to reducing assay time through automation, this design incorporates microfluidic designs that allow whole fixed cells as input, and enables automated ChIP from as few as 2,000 cells. Finally, using this high-sensitivity ChIP device in conjunction with next-generation sequencing technology, a protocol for determining genome-wide epigenetic landscapes from as few as 2,000 cells is developed, with the ultimate goal of performing protein-DNA association studies on CSCs.
  • Digital
    edited by Gareth Jenkins, Colin D. Mansfield.
    Digital : Springer Protocols2013
    Present technology and future trends in point-of-care microfluidic diagnostics / Lawrence Kulinsky, Zahra Noroozi, and Marc Madou -- Teaching microfluidic diagnostics using Jell-O® chips / Cheng Wei T. Yang and Eric T. Lagally -- Fundamentals of microfluidics for high school students with no prior knowledge of fluid mechanics / Vishal Tandon and Walter Peck -- Measuring microchannel electroosmotic mobility and zeta potential by the current monitoring method / Chenren Shao and Don L. DeVoe -- Overview of the microfluidic diagnostics commercial landscape / Lily Kim -- Practical aspects of the preparation and filing of patent applications / Fiona Bessoth -- Introduction to in vitro diagnostic device regulatory requirements / Jonathan Day -- Microfluidic device fabrication by thermoplastic hot-embossing / Shuang Yang and Don L. DeVoe -- Introduction to glass microstructuring techniques / Radoslaw Mazurczyk and Colin D. Mansfield -- Glass microstructure capping and bonding techniques / Radoslaw Mazurczyk, Colin D. Mansfield, and Marcin Lygan -- Rapid prototyping of PDMS devices using SU-8 lithography / Gareth Jenkins -- Microfluidic interface technology based on stereolithography for glass-based lab-on-a-chips / Song-I Han and Ki-Ho Han -- Three-dimensional, paper-based microfluidic devices containing internal timers for running time-based diagnostic assays / Scott T. Phillips and Nicole K. Thom -- Thread based devices for low-cost diagnostics / Meital Reches -- Droplet-based microfluidics / Sanjiv Sharma [and others] -- Droplet-based microfluidics for binding assays and kinetics based on FRET / Monpichar Srisa-Art and Sanjiv Sharma -- Surface treatments for microfluidic biocompatibility / N.J. Shirtcliffe, R. Toon, and P. Roach -- Superhydrophobicity for antifouling microfluidic surfaces / N.J. Shirtcliffe and P. Roach -- Application of microfluidic devices for viral diagnosis in developing countries / Samantha M. Hattersley, John Greenman, and Stephen J. Haswell -- Applications of microfluidics for molecular diagnostics / Harikrishnan Jayamohan, Himanshu J. Sant, and Bruce K. Gale -- Quantitative heterogeneous immunoassays in protein modified polydimethylsiloxane microfluidic channels for rapid detection of disease biomarkers / Peng Li -- Breast cancer diagnostics using microfluidic multiplexed immunohistochemistry / Minseok S. Kim, Seyong Kwon, and Je-Kyun Park -- Charged-coupled device (CCD) detectors for lab-on-a chip (LOC) optical analysis / Avraham Rasooly, Yordan Kostov, and Hugh A. Bruck -- Multilayer microfluidic poly(ethylene glycol) diacrylate hydrogels / Michael P. Cuchiara and Jennifer L. West -- Purification of DNA/RNA in a microfluidic device / Andy Fan, Samantha Byrnes, and Catherine Klapperich -- Agarose droplet microfluidics for highly parallel and efficient single molecule emulsion PCR / Xuefei Leng and Chaoyong James Yang -- Integrated fluidic circuits (IFCs) for digital PCR / Ramesh Ramakrishnan [and others] -- microFIND® approach to fluorescent in situ hybridization (FISH) / Andrea Zanardi, Emanuele Barborini, and Roberta Carbone -- ELISA lab-on-a-chip (ELISA-LOC) / Avraham Rasooly, Hugh A. Bruck, and Yordan Kostov -- Multiplexed surface plasmon resonance imaging for protein biomarker analysis / Eric Ouellet, Louise Lund, and Eric T. Lagally -- Surface acoustic wave (SAW) biosensors : coupling of sensing layers and measurement / Kerstin Lange, Friederike J. Gruhl, and Michael Rapp -- Microchip UV absorbance detection applied to isoelectric focusing of proteins / Junjie Ou and Carolyn L. Ren.
  • Digital
    edited by Bertrand Joseph, José Luis Venero.
    Digital : Springer Protocols2013
    Part I Overview of microglia biology -- Brief overview of multitalented microglia / Bertrand Joseph and José Luis Venero -- Part II Isolation and culture of microglia -- Cell culturing of human and murine microglia cell lines / Johanna Rodhe -- Microglia isolation from adult mouse brain / Jae-Kyung Lee and Malú G. Tansey -- Preparation of primary microglia cultures from postnatal mouse and rat brains / Tomas Deierborg -- Isolation of murine postnatal brain microglia for phenotypic characterization using magnetic cell separation technology / Ashley S. Harms and Malú G. Tansey -- Isolation and culture of adult human microglia within mixed glial cultures for functional experimentation and high-content analysis / Amy M. Smith ... [et al.] -- Part III Depletion and transduction of microglia -- Depletion of microglia from primary cellular cultures / Lorena Pont-Lezica, Sabrina Colasse, and Alain Bessis -- Lentiviral transduction of cultured microglia / Takahiro Masuda ... [et al.] -- Part IV Analysis of microglial cytokine production -- Microglial activation : measurement of cytokines by flow cytometry / Deepak Kumar Kaushik and Anirban Basu -- In situ hybridization of cytokine mRNA using alkaline phosphatase-labelled oligodeoxynucleotide probes / Bettina Clausen, Christina Fenger, and Bente Finsen -- Use of meso-scale discovery to examine cytokine content in microglia cell supernatant / Miguel A. Burguillos -- Part V Analysis of microglia activation -- Analysis of microglial production of reactive oxygen and nitrogen species / Urte Neniskyte and Guy C. Brown -- Quantification of active caspase-3 and active caspase-8 in microglia cells / Edel Kavanagh -- Quantification of microglial phagocytosis by a flow cytometer-based assay / Refik Pul, Kandiyil Prajeeth Chittappen, and Martin Stangel -- Quantification of microglial proliferation and apoptosis by flow cytometry / Alicia A. Babcock, Martin Wirenfeldt, and Bente Finsen -- Fluorescence imaging of intracellular Ca2+, Na+, and H+ in cultured microglia / Tom Schilling and Claudia Eder -- Patch clamp protocols to study ion channel activity in microglia / Tom Schilling and Claudia Eder -- Part VI Analysis of microglia polarization -- Studying M1 and M2 states in adult microglia / Sadanand M. Gaikwad and Michael T. Heneka -- Isolating, culturing, and polarizing primary human adult and fetal microglia / Bryce A. Durafourt ... [et al.] -- Part VII Co-culture systems to analysis microglia interactions with other cell types -- Understanding microglia-neuron cross talk : relevance of the microglia-neuron cocultures / Fernando G. Correa, Miriam Hernangómez, and Carmen Guaza -- Preparation of rodent primary cultures for neuron-glia, mixed glia, enriched microglia, and reconstituted cultures with microglia / Shih-Heng Chen, Esteban A. Oyarzabal, and Jau-Shyong Hong -- Part VIII Analysis of microglia functions in vivo -- Microglia detection by enzymatic histochemistry / Beatriz Almolda, Berta González, and Bernardo Castellano -- Tomato lectin histochemistry for microglial visualization / Nàdia Villacampa ... [et al.] -- Immunohistochemical detection of microglia / Rocío M. de Pablos, Ana M. Espinosa-Oliva, and Antonio J. Herrera -- Intrathecal Infusion of Microglia Cells / Takahiro Masuda ... [et al.] -- Intracranial injection of LPS in rat as animal model of neuroinflammation / Ana M. Espinosa-Oliva, Rocío M. de Pablos, and Antonio J. Herrera -- Analyses of microglia effector function using CX3CR1-GFP knock-in mice / Jenny A. Garcia, Sandra M. Cardona, and Astrid E. Cardona -- In vivo two-photon microscopy of microglia / Satoru Kondo and Shigeo Okabe -- Use of confocal microscopy in the study of microglia in a brain metastasis model / Manuel Sarmiento.
  • Digital
    Erik Seedhouse.
    Digital : Springer2015
    1. Introduction -- 2. Long Duration Flight Data -- 3. Earthbound and Microgravity Pathophysiology of Increased Intracranial Pressure -- 4. Papilledema and Microgravity-Induced Fluid Shift -- 5. The Role of Carbon Dioxide and Exercise -- 6. Diet and Personalized Medicine -- 7. Future Research -- Glossary -- Index.
  • Digital
    volume editors, Hideyasu Oh, Yusuke Oshima.
    Digital : Karger2014
  • Digital
    edited by David J. Carroll.
    Digital : Springer Protocols2009
    Expression of exogenous mRNA in Xenopus laevis embryos for the study of cell cycle regulation / Jill C. Sible and Brian N. Wroble -- Use of luciferase chimaera to monitor PLC[zeta] expression in mouse eggs / Karl Swann ... [et al.] -- Analysis of 14-3-3 family member function in Xenopus embryos by microinjection of antisense morpholino oligos / Jeffrey M.S. Lau and Anthony J. Muslin -- A microinjectable biological system, the Xenopus oocyte, as an approach to understanding signal transduction protein function / Katia Cailliau and Edith Browaeys-Poly -- Combining microinjection and immunoblotting to analyse MAP kinase phosphorylation in single starfish oocytes and eggs / David J. Carroll and Wei Hua -- Analysis of signaling pathways in zebrafish development by microinjection / William H. Kinsey -- Protein inhibition by microinjection and RNA-mediated interference in tissue culture cells : complementary approaches to study protein function / Jane R. Stout, Rania S. Rizk, and Claire E. Walczak -- DNA delivery by microinjection for the generation of recombinant mammalian cell lines / Sebastien Chenuet ... [et al.] -- Bacteriophage [phi]C31 integrase mediated transgenesis in Xenopus laevis for protein expression at endogenous levels / Bryan G. Allen and Daniel L. Weeks -- Germline transformation of Caenorhabditis elegans by injection / Pavan Kadandale, Indrani Chatterjee, and Andrew Singson -- Quantitative microinjection of mouse oocytes and eggs / Douglas Kline -- Microinjection of follicle-enclosed mouse oocytes / Laurinda A. Jaffe ... [et al.] -- Functional studies of regulatory genes in the sea urchin embryo / Vincenzo Cavalieri, Maria Di Bernardo, and Giovanni Spinelli -- Exploring the cytoskeleton during intracytoplasmic sperm injection in humans / Vanesa Y. Rawe and Héctor Chemes -- Somatic cell nuclear transfer in the mouse / Satoshi Kishigami and Teruhiko Wakayama.
  • Digital
    S. Morand, B.R. Krasnov, R. Poulin (eds.).
    Digital : Springer2006
    Micromammals and macroparasites : who is who and how they interact? / S. Morand ... [et al.] -- Digenean trematodes / C. Feliu ... [et al.] -- Cestodes of small mammals : taxonomy and life cycles / B.B. Georgiev, R.A. Bray and D.T.J. Littlewood -- Nematodes / S. Morand, S. Bouamer and J.-P Hugot -- Acanthocephalans / A. Ribas and J.C. Casanova -- Taxonomy, host associations, life cycles and vectorial importance of ticks parasitizing small mammals / L.A. Durden -- Mesostigmatid mites as parasites of small mammals : systematics, ecology, and the evolution of parasitic associations / A.P.G. Dowling -- Taxonomy, life cycles and the origin of parasitism in trombiculid mites / A.B. Shatrov and J.I. Kudryashova -- Blood-sucking lice (Anoplura) of small mammals : true parasites / K.C. Kim -- Fleas : permanent satellites of small mammals / S.G. Medvedev and B.R. Krasnov -- Bat flies : obligate ectoparasites of bats / C.W. Dick and B.D. Patterson -- Patterns of macroparasite diversity in small mammals / B.R. Krasnov, R. Poulin and S. Morand -- Patterns of host specificity in parasites exploiting small mammals / R. Poulin, B.R. Krasnov and S. Morand -- Coevolution of macroparasites and their small mammalian hosts : cophylogeny and coadaptation / J.-P. Hugot -- Comparative phylogeography : the use of parasites for insights into host history / Cj.M. Nieberding and S. Morand -- Insularity and micromammal-macroparasite relationships / E. Magnanou and S. Morand -- Models for host-macroparasite interactions in micromammals / R. Rosà ... [et al.] -- Transmission ecology and the structure of parasite communities /aI.M. Cattadori ... [et al.] -- Effect of macroparasites on the energy budget of small mammals / A.A. Degen -- Immunogenetics of micromammal-macroparasite interactions / N. Charbonnel, J. Goüy de Bellocq and S. Morand -- Interactions among immune, endocrine, and behavioural response to infection / Z.M. Weil, L.B. Martin II and R.J. Nelson -- Behaviour, life history strategies and parasite infection in rodents / C.J. Barnard and J.M. Behnke -- Nematode zoonoses / J.C. Casanova, A. Ribas and J.M. Segovia -- Rodents as definitive hosts of Schistosoma, with special reference to S. mansoni transmission / J.-M. Duplantier and M. Sene -- Towards understanding the impacts of environmental variation on Echinococcus multilocularis transmission / D.R.J. Pleydell ... [et al.] -- Parasites and pest population management / H. Leirs and G.R. Singleton -- Biological conservation and parasitism / P. Christe, S. Morand and J. Michaux -- Global changes and the future of micromammal-macroparasite interactions / S. Morand, R. Poulin and B.R. Krasnov.
  • Digital
    Ryan F. Donnelly, Thakur Raghu Raj Singh, Desmond I.J. Morrow, A. David Woolfson.
    Digital : Wiley2012
    Transdermal drug delivery -- Microneedles : design, microfabrication and optimization -- Microneedle applicator designs for transdermal drug delivery applications -- Transdermal delivery applications -- Microneedle-mediated intradermal delivery -- Clinical application and safety studies of microneedles -- Microneedles : current status and future perspectives.
  • Digital
    edited by Burt Anderson, Herman Friedman, and Mauro Bendinelli.
    Digital : Springer2006
    Biotechnology and the public health response to bioterrorism -- Historical perspectives of microbial bioterrorism -- The infectious disease physician and microbial bioterrorism -- Modulation of innate immunity to protect against biological weapon threat -- Smallpox: pathogenesis and host immune responses relevant to vaccine and therapeutic strategies -- Bacillus anthracis: agent of bioterror and disease -- Tularemia pathogenesis and immunity -- Brucella and bioterrorism -- Pneumonic plague -- Coxiella burnetii, Q fever, and bioterrorism -- Genomic and proteomic approaches against Q fever -- Rickettsia rickettsii and other members of the spotted fever group as potential bioweapons.
  • Digital
    edited by Brian Flannigan, Robert A. Samson, J. David Miller.
    Digital : CRCnetBASE2011
    Machine generated contents note: ch. 1 Microorganisms in air -- 1.1.Microorganisms in outdoor air / B. Flannigan -- 1.2.Microorganisms in indoor air / B. Flannigan -- 1.3.Pollen in indoor air / A. Rantio-Lehtimaki -- ch. 2 Microorganisms in homes and work environments -- 2.1.Microbial growth in indoor environments / J.D. Miller -- 2.2.Bacteria and other bioaerosols in industrial workplaces / J.R.M. Swan -- 2.3.Remediation and control of microbial growth in problem buildings / P.R. Morey -- ch. 3 Airborne microorganisms and disease -- 3.1.Allergenic microorganisms and hypersensitivity / J.H. Day -- 3.2.Occupational respiratory disease: hypersensitivity pneumonitis and other forms of interstitial lung disease / B. Flannigan -- 3.3.Respiratory tract infections caused by indoor fungi / R.C. Summerbell -- ch. 4 Microbiological investigation of indoor environments -- 4.1.Mycological investigations of indoor environments / J.D. Miller -- 4.2.Molecular methods for bioaerosol characterization / J.A. Scott -- 4.3.Isolation and identification of fungi / J. Houbraken -- 4.4.Analysis of microbial volatile organic compounds / T.J. Ryan -- 4.5.Analysis for toxins and inflammatory compounds / J.D. Miller -- 4.6.Interpreting sampling data in investigations of indoor environments: selected case studies / P.R. Morey -- ch. 5 Common and important species of Actinobacteria and fungi in indoor environments -- Common and important species of fungi and actinomycetes in indoor environments / J.D. Miller -- Descriptions and illustrations of common fungi and actinomycetes.
  • Digital
    edited by Matthieu Piel and Manuel Théry.
    Digital : ScienceDirectpt. A-C, 2014
    Digital : ScienceDirectPt. A
    Digital : ScienceDirectPt. B
    Digital : ScienceDirectPt. C
    "Micropatterning refers generally to techniques which provide an experimental control over the chemical, physical, or geometrical properties of materials at the micron or submicron scale, and are thus used to produce spatial patterns of these properties. These techniques, which were often originally designed for application in microelectronics, have spread over most areas of science, including biology. They have proved particularly useful for cell biology, bridging the gap between the Petri-dish and complex 3D assays and tissues."--Preface.
  • Digital
    Edoardo Midena, editor.
    Digital : Springer2014
    Microperimetry and Multimodal Retinal Imaging: the Fundamentals: Functional Evaluation of the Retina: an Introduction -- Retinal Fixation and Microperimetry -- Microperimetry: technical remarks -- OCT/SLO Microperimetry and Correlates -- Scotopic microperimetry -- Multimodal retinal imaging: an Introduction. Clinical Applications of Microperimetry and Multimodal Retina Imaging: Early and Intermediate Age-Related Macular Degeneration -- Geographic atrophy -- Neovascular age-related macular degeneration -- Retinal Pigment Epithelium and Choroid Graft -- Macular Telangiectasia Type 2 -- Diabetes and Retinal Vascular Disorders -- Myopia -- Retinal Dystrophies -- Disorders of the vitreoretinal interface -- Inflammatory chorio-retinal diseases -- Toxic retinopathies -- Glaucoma. The contribution to visual rehabilitation: Low vision: diagnosis and rehabilitation.
  • Digital
    Gaetano Santulli, editor.
    Digital : Springer2015
    Print2015
    1. A fleeting glimpse inside microRNA, epigenetics and micropeptidomics -- 2. The microRNA machinery -- 3. microRNAs in mitochondria: an unexplored niche -- 4. microRNAs distinctively regulate vascular smooth muscle and endothelial cells: functional implications in angiogenesis, atherosclerosis, and in-stent restenosis -- 5. Mechanistic role of microRNAs in coupling lipid metabolism and atherosclerosis -- 6. microRNAs in pancreatic β-cell physiology -- 7. microRNA and cardiac regeneration -- 8. microRNAs and endometrial pathophysiology -- 9. microRNA and NF-kappa B -- 10. microRNAs: key players in hematopoiesis -- 11. Regulatory roles of miRNAs in aging -- 12. Computational prediction of microRNA targets
  • Digital
    Gaetano Santulli, editor.
    Digital : Springer2015
    Print2015
    microRNAs in the malignant transformation process / Anne E. Sarver, Lihua Li, Reena V. Kartha, Subbaya Subramanian -- microRNA and chronic lymphocytic leukemia / Dana Elena Giza, George A. Calin -- microRNA in malignant lymphoma / Hiroyuki Tagawa -- MicroRNAs and gastrointestinal stromal tumor / Pinar Akçakaya, Weng-Onn Lui -- Insights into the role of microRNAs in pancreatic cancer pathogenesis: potential for diagnosis, prognosis, and therapy / Mohammad Aslam Khan [and others] -- microRNAs and colorectal cancer / Anna Lena Ress, Samantha Perakis, Martin Pichler -- microRNAs and prostate cancer / Sajni Josson, Leland W. K. Chung, Murali Gururajan -- microRNA and ovarian cancer / Ream Langhe -- microRNA and lung cancer / Valerio Del Vescovo, Michela A. Denti -- microRNAs and soft tissue sarcomas / Tomohiro Fujiwara, Toshiyuki Kunisada, Ken Takeda, Toshifumi Ozaki -- microRNA and bone cancer / Mary Nugent.
  • Digital
    Gaetano Santulli, editor.
    Digital : Springer2015
    Print2015
    Exploiting microRNA specificity and selectivity: paving a sustainable path towards precision medicine / Gaetano Santulli -- microRNAs and personalized medicine: evaluating their potential as cancer biomarkers / Anne Saumet and Charles-Henri Lecellier -- microRNA and pain / Atsushi Sakai and Hidenori Suzuki -- microRNA and epilepsy / Cristina R. Reschke and David C. Henshall -- microRNA and autism / Ayyappan Anitha and Ismail Thanseem -- microRNAs and neurogenerative diseases / Lifeng Qiu, Eng King Tan, and Li Zeng -- microRNAs and Fragile X Syndrome / Shi-Lung Lin -- The emerging role of mitomiRs in the pathophysiology of human disease / Filipe V. Duarte, Carlos M. Palmeira, and Anabela P. Rolo -- microRNAs in cerebrovascualar disease / Ondřej Volný, Linda Kašičková, Dominika Coufalová, Petra Cimflová, and Jan Novák -- microRNAs and cardiovascular remodeling / Koh Ono -- microRNAs in essential hypertension and blood pressure regulation / Francine Z. Marques and Fadi J. Charchar -- microRNA and pulmonary hypertension / Olivier Boucherat, François Potus, and Sébastien Bonnet -- microRNAs in diabetic kidney disease / Arthur C.K. Chung -- microRNA and kidney transplantation / Kíra Jelencsics and Rainer Oberbauer -- microRNA and wound healing / Jaideep Banerjee and Chandan K. Sen -- Essential role of microRNA in skin physiology and disease / Damjan Glavač and Metka Ravnik-Glavač -- microRNA and allergy / Ana Rebane -- microRNA in human reproduction / Iris Eisenberg, Noora Kotaja, Debra Goldman-Wohl, and Tal Imbar -- microRNAs and hepatitis B / Yutaka Naito, Yasuhito Tanaka, and Takahiro Ochiya -- Circulating microRNAs: the future of biomarkers in anti-doping field / Nicolas Leuenberger and Martial Saugy -- microRNA expression profiling: technologies, insights, and prospects / Christine Roden, Stephen Mastriano, Nayi Wang, and Jun Lu.
  • Digital
    edited by Wei Wu.
    Digital : Springer Protocols2011
    MicroRNA Biogenesis and Cancer / Julia Winter, Sven Diederichs -- Computational Identification of miRNAs Involved in Cancer / Anastasis Oulas, Nestoras Karathanasis, Panayiota Poirazi -- The Principles of MiRNA-Masking Antisense Oligonucleotides Technology / Zhiguo Wang -- The Concept of Multiple-Target Anti-miRNA Antisense Oligonucleotide Technology / Zhiguo Wang -- Modulation of MicroRNAs for Potential Cancer Therapeutics / Wei Wu -- Detection of MicroRNAs in Cultured Cells and Paraffin-Embedded Tissue Specimens by In Situ Hybridization / Ashim Gupta, Yin-Yuan Mo -- MicroRNA Northern Blotting, Precursor Cloning, and Ago2-Improved RNA Interference / Julia Winter, Sven Diederichs -- miRNA Profiling on High-Throughput OpenArray System / Elena V. Grigorenko, Elen Ortenberg, James Hurley, Andrew Bond, Kevin Munnelly -- Silicon Nanowire Biosensor for Ultrasensitive and Label-Free Direct Detection of miRNAs / Guo-Jun Zhang -- High-Throughput and Reliable Protocols for Animal MicroRNA Library Cloning / Caide Xiao -- MicroRNA Regulation of Growth Factor Receptor Signaling in Human Cancer Cells / Keith M. Giles, Andrew Barker, Priscilla M. Zhang, Michael R. Epis, Peter J. Leedman -- Epigenetic Regulation of MicroRNA Expression in Cancer / Hani Choudhry, James W. Catto -- In Vitro Functional Study of miR-126 in Leukemia / Zejuan Li, Jianjun Chen -- Prediction of the Biological Effect of Polymorphisms Within MicroRNA Binding Sites / Debora Landi, Roberto Barale, Federica Gemignani, Stefano Landi -- The Guideline of the Design and Validation of MiRNA Mimics / Zhiguo Wang -- Analysis of Targets and Functions Coregulated by MicroRNAs / Shu-Jen Chen, Hua-Chien Chen -- Utilization of SSCprofiler to Predict a New miRNA Gene / Anastasis Oulas, Panayiota Poirazi -- MicroRNA Profiling Using Fluorescence-Labeled Beads: Data Acquisition and Processing / Thomas Streichert, Benjamin Otto, Ulrich Lehmann.
  • Digital
    edited by Ulf Schmitz, Olaf Wolkenhauer, Julio Vera.
    Digital : Springer2013
    Print2013
    "This book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology." --Publisher's description.
  • Digital
    Steven Schaffert.
    Digital2013
    Much has been learned about the molecular and cellular components critical for the control of immune responses and tolerance. It remains a challenge, however, to control the immune response and tolerance at the system level without causing significant toxicity to normal tissues. Recent studies suggest that microRNAs (miRNAs), an abundant class of ~22 nucleotides regulatory RNAs, play important roles in immune cells. In this thesis, I examined the function of miR-181 genes in regulating T cell selection, development, and immune tolerance. We show that genetic ablation of mir-181a-1/b-1 ---- a T cell sensitivity tuner ---- in double-positive (DP) thymocytes dampens TCR and Erk signaling and affects positive selection. Moreover, dampening TCR signaling as the result of mir-181a-1/b-1 deletion potentiates the reactivity of self-specific T cells without significantly affecting the pool sizes of naive T cells recognizing specific self-antigens. Finally, loss of mir-181a-1/b-1 in peripheral T cells reduces their basal TCR signaling and their ability to migrate from lymph nodes to the pathogenic sites during autoimmune perturbations. Interestingly, loss of mir-181a-1/b-1 results in quantitative defects in various T and B lymphocyte populations, but does not cause major structural damage to the immune system or spontaneous autoimmunity. Our findings illustrate that mir-181a-1/b-1 controls tolerance through opposing activities in selection and peripheral T cell function. Thus, despite the subtle effects of miRNAs on gene expression, miRNAs have the potential to influence the outcomes of normal and pathogenic immune responses by controlling the quantitative and dynamic aspects of immune responses.
  • Digital
    Zhiguo Wang, Baofeng Yang.
    Digital : Springer2010
  • Digital
    Suresh Alahari, editor.
    Digital : Springer2013
    The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
  • Digital
    Zhiguo Wang.
    Digital : Springer2009.
  • Digital
    Xuyang Sun.
    Digital2012
    Mammalian neurogenesis - an elagant process of producing extraodinarily diversified neuronal propulations - has been largely studied in the context of evoluationarily conserved signalling pathways and neurogenic transcription factors. Yet little is known about the roles of chromatin remodellers and regulatory RNAs, such as microRNAs, in the formation of neurons. We recently discovered that miR-9* and miR-124 instruct compositional changes of SWI/SNF-like BAF chromatin-remodelling complexes during murine nervous development, a process important for neuronal differentiation and function. Here I set out to directly test the neurogenic activity of these microRNAs in human non-neuronal cells. Together with Andrew Yoo, I showed that ectopic expression of miR-9/9* and miR-124 (miR-9/9*-124) in human dermal fibroblasts induces their conversion into neurons (chapter 2). Addition of neurogenic transcription factors such as NEUROD2, ASCL1 and MYT1L enhances the rate of conversion and the maturation of the converted neurons, whereas expression of these transcription factors alone without miR-9/9*-124 appeared ineffective. As a step closer to cell replacement therapy, I next showed that these microRNAs could directly convert human astrocytes into neurons, of which the subtype identity can be further biased by specfic neurogenic factors (chapeter 3). Collectively, these studies indicate that the genetic circuitry involving miR-9/9*-124 and BAF chromatin remodelling complex can have an instructive role in neuronal fate determination, and may form a neuronal ground state that can be further specified by different transciption factors and/or signalling pathways.
  • Digital
    edited by John J. Rossi, Gregory J. Hannon.
    Digital : ScienceDirect2007
    Print2007
  • Digital
    edited by Yuriy Gusev.
    Digital : CRCnetBASE2010
    Measurement and interpretation of microRNA expression profiles / Bo Curry and Robert Ach -- MicroRNA expression analysis by LNA enhanced microarrays / Rolf Sokilde ... [et al.] -- Analysis and QC for real-time OPCR arrays of human microRNAs / Dirk P. Ditmer ... [et al.] -- Massively parallel microRNA profiling in the haematologic malignancies / Ryan D. Morin ... [et al.] -- Who dunit? microRNAs involved in prostate cancer / Chang Hee Kim -- Intronic microRNA : creation, evolution and regulation / Sailen Barik and Titus Barik -- miRome architechture and genomic instability / Konrad Huppi ... [et al.] -- Interconnection of microRNA and transcription factor-mediated regulatory networks / Yiming Zhou -- Analysis of microRNA profiling data with systems biology tools / Yuriy Gusev ... [et al.] -- Mathematical and computational modeling of post-transriptional gene regulation by microRNAs / Raya Khanin and Desmond J. Higham.
  • Digital
    edited by Shao-Yao Ying.
    Digital : Springer Protocols2012
    MicroRNA / Shao-Yao Ying, Donald C. Chang, and Shi-Lung Lin -- Analysis of MicroRNA length variety generated by recombinant human dicer / Julia Starega-Roslan and Wlodzimierz J. Krzyzosiak -- User-friendly computational workflow for the analysis of MicroRNA deep sequencing data / Anna Majer, Kyle A. Caligiuri, and Stephanie A. Booth -- RNA gene information : retroelement-MicroRNA entangling as the RNA quantum code / Yoichi Robertus Fujii -- Setting up an intronic miRNA database / Ludwig Christian Hinske [and others] -- Identify intronic MicroRNA with bioinformatics / Chih-Hao Kuo [and others] -- Experimental miRNA target validation / Jens Heyn [and others] -- Enrichment analysis of miRNA targets / Jianzhen Xu and Chi-Wai Wong -- MicroRNA expression profiling during neural differentiation of mouse embryonic carcinoma P19 cells / Botao Zhao [and others] -- Evaluating the MicroRNA targeting sites by luciferase reporter gene assay / Yi Jin [and others] -- Expression pattern analysis of MicroRNAs in Caenorhabditis elegans / Meltem Isik and Eugene Berezikov -- Use of viral systems to study miRNA-mediated regulation of gene expression in human cells / Eleonora Forte and Micah A. Luftig -- Cloning, expression, and functional analysis of genomic miRNA using retroviral system in cancer cells / Abdol Hossein Rezaeian, Yuan Gao, and Hui-Kuan Lin -- Preparing synaptoneurosomes from adult mouse forebrain / Giovanni Lugli and Neil R. Smalheiser -- Isolation of total RNA and detection procedures for miRNA present in bovine-cultured adipocytes and adipose tissues / Scott L. Pratt [and others] -- miRNA and shRNA expression vectors based on mRNA and miRNA processing / Ping Wu [and others] -- Gene silencing in vitro and in vivo using intronic MicroRNAs / Shi-Lung Lin and Shao-Yao Ying -- Vector-free methods for manipulating miRNA activity in vitro and in vivo / Angeliki Pantazi and Athanasios Zovoilis -- MicroRNA expression profiling of human-induced pluripotent and embryonic stem cells / Amit Sharma and Joseph C. Wu -- MicroRNA expression during neuronal differentiation of human teratocarcinoma NTera2D1 and mouse embryonic carcinoma P19 cells / Hirohiko Hohjoh -- Isolation and identification of gene-specific MicroRNAs / Shi-Lung Lin, Donald C. Chang, and Shao-Yao Ying -- Transgene-like animal models using intronic MicroRNAs / Shi-Lung Lin, Shin-Ju E. Chang, and Shao-Yao Ying -- Mechanism and method for generating tumor-free iPS cells using intronic MicroRNA miR-302 induction / Shi-Lung Lin and Shao-Yao Ying -- Salivary MicroRNAs and oral cancer detection / Janice M. Yoshizawa and David T.W. Wong -- Application of intronic MicroRNA agents in cosmetics / Jack S.K. Chen and David T.S. Wu -- MicroRNAs in skin and wound healing / Jaideep Banerjee and Chandan K. Sen -- MiRNA targets of prostate cancer / Jia Han Deng [and others].
  • Digital
    Catherine M. Greene, editor.
    Digital : Springer2015
    Print2015
    The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohnĺls disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
  • Digital
    edited by Silvia Monticelli.
    Digital : Springer Protocols2010
    A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation -- Normalization of microRNA quantitative RT-PCR data in reduced scale experimental designs -- MicroRNA detection in bone marrow cells by LNA-FISH -- Measuring microRNA expression in size-limited facs-sorted and microdissected samples -- MicroRNA cloning from cells of the immune system -- High-throughput profiling in the hematopoietic system -- Construction of small RNA cDNA libraries for deep sequencing -- MicroRNA-profiling in formalin-fixed paraffin-embedded specimens -- Expression of miRNAs in lymphocytes : A review -- Mouse models for miRNA expression: The ROSA26 locus -- Regulation of monocytopoiesis by microRNAs -- MicroRNA activity in B lymphocytes -- Isolation and characterization of microRNAs of human mature erythrocytes -- Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors -- Monitoring microRNA activity and validating microRNA targets by reporter-based approaches -- Lentivirus-mediated antagomir expression -- Solution structure of miRNA:mRNA complex -- MiRNA editing -- Computational prediction of microRNA targets -- Large-scale integration of microRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems -- Identification and validation of the cellular targets of virus-encoded microRNAs.
  • Digital
    Niall Barron, editor.
    Digital : Springer2012
    "MicroRNAs are small, non-coding RNA molecules that interact with target mRNAs to modulate their translation. They are now recognized as widespread and critical regulators of gene expression in the cell. This book is aimed at both industry- and academic-based researchers in the Biopharmaceutical production space who wish to learn more about these fascinating molecules..."--Page [4] of cover.
  • Digital
    William C.S. Cho, editor.
    Digital : Springer2011
    1 -- MicroRNAs in Cancer (An Overview) -- 2. The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis -- 3. MicroRNAs in Breast Cancer -- 4. MicroRNAs in Colorectal Cancer -- 5. MicroRNAs in Gastric Cancer -- 6. MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets?- 7. MicroRNAs in Hepatocellular Carcinoma -- 8. MicroRNAs in Cervical Carcinoma -- 9. MicroRNAs in Esophageal Cancer -- 10. MicroRNAs in Bladder Cancer -- 11. MicroRNAs in Lymphoma -- 12. MicroRNAs in Leukemia -- 13. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools -- 14. MicroRNAs in Epithelial Ovarian Cancer -- 15. MicroRNAs in Brain Tumors -- 16. MicroRNAs and Cancer Stem Cells -- 17. MicroRNAs in Cancer Invasion and Metastasis -- 18. MicroRNAs in Predicting Radiotherapy and Chemotherapy Response -- 19. Role of MicroRNAs in Anti-cancer Drug Resistance -- 20. MicroRNAs and Cancer Metabolism -- 21. MicroRNAs as Blood-based Biomarkers of Cancer -- 22. RNAi-based Approaches to the Treatment of Brain Tumors.
  • Digital
    edited by Tamas Dalmay.
    Digital : Springer Protocols2011
    In situ detection of microRNAs in animals / Dylan Sweetman -- Detection of microRNAs in plants by in situ hybridisation / Eva Varallyay and Zoltan Havelda -- Detecting sRNAs by northern blotting / Sara Lopez-Gomollon -- Profiling microRNAs by real-time PCR / Nanna Jacobsen, Ditte Andreasen, and Peter Mouritzen -- Detection of small RNAs and microRNAs using deep sequencing technology / Ericka R. Havecker -- Detection of microRNAs in prostate cancer cells by mircoRNA array / Xiaoqing Tang [and others] -- MicroRNA knock down by cholesterol-conjugated antisence oligos in mouse organ culture / Sharon Kredo-Russo and Eran Hornstein -- Protocols for use of homologous recombination gene targeting to produce microRNA mutants in drosophila / Ya-Wen Chen, Ruifen Weng, and Stephen M. Cohen -- Engineering elements for gene silencing : the artificial microRNAs technology / Pablo Andres Manavella and Ignacio Rubio-Somoza -- Mimicry technology : suppressing small RNA activity in plants / Ignacio Rubio-Somoza and Pablo Andres Manavella -- Experimental validation of microRNA targets using a luciferase reporter system / Francisco E. Nicolas -- Experimental identification of microRNA targets by immunoprecipitation of argonaute protein complexes / Michaela Beitzinger and Gunter Meister -- Comprehensive identification of miRNA target sites in live animals / Dimitrios G. Zisoulis, Gene W. Yeo, and Amy E. Pasquinelli -- Target validation of plant microRNAs / Cesar Llave [and others] -- High-throughput sequencing-based methodology to identify all uncapped and cleaved RNA molecules in eukaryotic genomes / Matthew W. Endres, Rebecca T. Cook, and Brian D. Gregory.
  • Digital
    Michael Sand.
    Digital : Springer2016
    Introduction -- Objectives of this work -- Summary and discussion of this work -- Closing remarks -- Paper 1: Expression levels of the microRNA processing enzymes Drosha and Dicer in epithelial skin cancer -- Paper 2: Expression levels of the microRNA maturing microprocessor complex component DGCR8 and the RNA- induced silencing complex (RISC) components argonaute-1, argonaute-2, PACT, TARBP1 and TARBP2 in epithelial skin cancer -- Paper 3: Expression of microRNAs in basal cell carcinoma -- Paper 4: Microarray analysis of microRNA expression in cutaneous squamous cell carcinoma -- Paper 5: The miRNA machinery in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi -- Paper 6: Immunohistochemical expression patterns of the microRNA-processing enzyme Dicer in cutaneous malignant melanomas, benign melanocytic nevi and dysplastic melanocytic nevi -- Paper 7: Comparative microarray analysis of microRNA expression profiles in primary cutaneous malignant melanoma, cutaneous malignant melanoma metastases and benign melanocytic nevi -- Paper 8: MicroRNAs and the skin: tiny players in the body's largest organ -- Paper 9: microRNA in non-melanoma skin cancer.
  • Digital
    edited by Stella K. Kantartzi.
    Digital : Springer Protocols2013
    Microsatellites or simple sequence repeats (SSRs) have become the markers of choice for a variety of molecular studies because of their versatility, operational flexibility, and lower cost than other marker systems. Microsatellites: Methods and Protocols brings together experts in the field to cover this significant area of research. Broken in to four convenient parts, this volume delves into classical and modern methods for the discovery and development of microsatellite markers, descriptions of amplification and visualization of SSRs, automated capillary sequencers that are widely used for fragment analysis, as well as a variety of methods for the analysis of data obtained by the use of microsatellites. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and invaluable, Microsatellites: Methods and Protocols aims at researchers that need detailed protocols for incorporating microsatellite markers into their projects and expert scientists looking to expand their knowledge of SSRs discovery, use, and analysis.
  • Print
    Ugo Fisch, Christoph Mörgeli, Albert Mudry ; Museum of History of the University of Zurich.
    Print2012
    Status: Not Checked OutLane Catalog Record
    "This book elucidates the development of the surgical therapy of ear diseases from antiquity to the middle ages and modern times up to the present."--Preface.
  • Digital
    edited by Bojan Čalija.
    Digital : ScienceDirect2017
  • Digital
    Devendra K. Gupta.
    Digital : Springer2009
  • Digital
    John L. Viescas, Jeff Conrad.
    Digital : ProQuest Safari2007
    Print2007
    1. Understanding Microsoft Access -- 2. Building an Access 2007 Desktop Application -- 3. Creating Forms and Reports in a Desktop Application -- 4. Automating an Access Application -- 5. Linking Access and the Web -- 6. After Completing Your Application -- 7. Designing an Access Project -- 8. Articles.
  • Print
    Mark Dodge, Craig Stinson.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Print
    Curtis D. Frye.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Digital
    Jim Boyce, Beth Sheresh, Doug Sheresh.
    Digital : ProQuest Safari2007
  • Digital
    Teresa S. Stover.
    Digital : ProQuest Safari2007
  • Digital
    Mark H. Walker.
    Digital : ProQuest Safari2007
  • Print
    Joyce Cox and Joan Preppernau.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Digital
    Peter G. Aitken.
    Digital : ProQuest Safari2007
  • Digital
    Faithe Wempen.
    Digital : ProQuest Safari2007
  • Digital
    Elaine Marmel.
    Digital : ProQuest Safari2007
  • Digital
    Scot P. Hillier.
    Digital : Springer2006
  • Digital
    Scot Hillier.
    Digital : Springer2007
  • Digital
    Herb Tyson.
    Digital : ProQuest Safari2007
  • Digital
    Guanghui Ma, Zhiguo Su.
    Digital : CRCnetBASE2013
    1. Microspheres for enzyme immobilization / Fei Gao, Yuxia Wang, and Guanghui Ma -- 2. Microspheres for cell culture / Weiqing Zhou, Guanghui Ma, and Zhiguo Su -- 3. Microcapsules for cell transplantation : design, preparation, and application / Guojun Lv, Ying Zhang, Mingqian Tan, Hongguo Xie, and Xiaojun Ma -- 4. Microspheres for the separation and refolding of proteins with an emphasis on particles made of agarose / Jan-Christer Janson -- 5. Microspheres for separation of bioactive small molecules / Fangling Gong, Guifeng Zhang, and Zhiguo Su -- 6. Microspheres for separation of PEG-modified biomolecules / Yongdong Huang, Yanqin Zhai, and Zhiguo Su -- 7. Microspheres for solid-phase organic synthesis / Jing Zhang and Zhiguo Su -- 8. Microspheres for solid-phase modification of proteins / Tao Hu and Zhiguo Su -- 9. Microspheres and microcapsules for protein drug delivery / Lianyan Wang, Tingyuan Yang, and Guanghui Ma -- 10. Micro/nanospheres for gene drug delivery / Jie Wu and Guanghui Ma -- 11. Microspheres for targeting delivery of anticancer drugs / Wei Wei, Zhanguo Yue, Hua Yue, and Guanghui Ma -- 12. Microspheres for targeting delivery to brain / Chen Jiang, Xinguo Jiang, Yang Liu, Kun Shao, and Rongqin Huang -- 13. Nano/microspheres in bioimaging and medical diagnosis / Xiaohui Li and Chunying Chen -- 14. Affinity nanoparticles for detection / Haruma Kawaguchi and Hiroshi Handa.
  • Digital
    Stefan Geyer, Robert Turner, editors.
    Digital : Springer2013
    Guy N. Elston, Laurence J. Garey: The cytoarchitectonic map of Korbinian Brodmann: Arealisation and circuit specialization -- Lazaros C. Triarhou: The cytoarchitectonic map of Constantin von Economo and Georg N. Koskinas -- Rudolf Nieuwenhuys: The myeloarchitectonic studies on the human cerebral cortex of the Vogt -- Vogt school, and their significance for the interpretation of functional neuroimaging data -- Bruce Fischl: Estimating the location of Brodmann Areas from cortical folding patterns using histology and ex vivo MRI -- Simon B. Eickhoff, Danilo Bzdok: Database-driven identification of functional modules in the cerebral cortex -- Robert Turner: Where matters: New approaches to brain analysis -- Robert Turner: MRI methods for in-vivo cortical parcellation -- Nicholas A. Bock, Afonso C. Silva: Visualizing myeloarchitecture in vivo with magnetic resonance imaging in common marmosets (Callithrix jacchus) -- Stefan Geyer: High-field magnetic resonance mapping of the border between primary motor (area 4) and somatosensory (area 3a) cortex in ex-vivo and in-vivo human brains.
  • Digital
    by M. G. Yaşargil.
    Digital : Thieme eNeurosurgery2007
  • Digital
    Jay I. Sandlow, editor.
    Digital : Springer2013
    Male Infertility Microsurgical Training / Philip S. Li, Ranjith Ramasamy and Marc Goldstein -- Microsurgery Training: What Should a Resident Know? Should All Microsurgeons be Fellowship Trained? / Ethan Grober and Peter N. Kolettis -- Microsurgical Subinguinal Varix Ligation: Techniques and Technical Pearls / Joshua A. Bodie and Jay I. Sandlow -- Vasovasostomy Techniques for Microsurgery Specialists / Kalen Rimar, Landon Trost and Robert E. Brannigan -- Epididymovasostomy: Tips and Tricks of the Trade / James F. Smith and Ajay K. Nangia -- Sperm Retrieval Techniques in Obstructive Azoospermia: MESA, PESA, and TESA / Anand Shridharani and Jay I. Sandlow -- Microsurgical Testicular Sperm Extraction: Technical Considerations / Peter N. Schlegel -- Noninfertility Scrotal Microsurgery / Akanksha Mehta and Marc Goldstein -- Testis-Sparing Surgery for Testicular Masses / Oleksandr Stakhovskyi and Michael A. S. Jewett -- Robotic Microsurgery for Male Infertility / Sijo J. Parekattil, Ahmet Gudeloglu and Jamin V. Brahmbhatt -- The Role of Microsurgical Reconstruction in the Era of ICSI / Karen Baker and Edmund Sabanegh Jr -- Tubal Microsurgery / Jeffrey M. Goldberg and Tommaso Falcone -- Microsurgical Penile Revascularization, Replantation, and Reconstruction / Jeffrey Lee Rosenblum and Arthur L. Burnett.
  • Print
    Richard C. Troutman ; with 457 tone drawings in 137 plates by Virginia Cantarella.
    Print1974-
    Status: Not Checked OutLane Catalog Record
  • Digital
    Toshio Matsushima.
    Digital : Springer2015
    This book provides the anatomy of the posterior fossa, together with the main associated surgical techniques, which are detailed in numerous photographs and step-by-step color illustrations. The text presents approaches and surgical techniques such as the trans-cerebellomedullary fissure approach and its variation to the fourth ventricle, as well as the cerebellomedullary cistern, infratentorial lateral supracerebellar approach to the fifth cranial nerve in the upper cerebellopontine angle, infrafloccular approach to the root exit zone of the seventh cranial nerve, transcondylar fossa approach through the lateral part of the foramen magnum, and the stitched sling retraction technique utilized during microvascular decompression procedures for trigeminal neuralgia and hemifacial spasm. It also describes in detail the bridging veins of the posterior fossa, especially the petrosal vein, and bridging veins to the tentorial sinuses, which can block approaches to the affected area. The original Japanese version of this work was published 8 years ago, and has established itself as a trusted guide, especially among young neurosurgeons who need to study various surgical approaches and techniques. In the course of being translated into English, some sections have been revised and new information has been added. The author hopes that the book will help neurosurgeons around the world perform safer operations with confidence.
  • Digital
    Hans-Jakob Steiger, Nima Etminan, Daniel Hänggi.
    Digital : Springer2015
    This compact book provides step-by-step guidance in the approaches and techniques developed and currently used at the authorsĺl center in D©ơsseldorf for the treatment of a variety of aneurysms. All of the described procedures are minimally invasive and of proven efficacy. In order to assist the reader in fully comprehending all aspects of the techniques, they are illustrated through clear graphics instead of complex photos and radiologic imaging. While the rapid development of endovascular treatment means that it is no longer necessary to employ microsurgery for difficult and hidden aneurysms, proficiency in microsurgery remains essential. For example, full mastery of microsurgical techniques is vital in order to treat middle cerebral and peripheral aneurysms efficiently and with minimal trauma. Minimal invasiveness and optimal cosmetic results have become critically important in enabling the microsurgical method to compete with the endovascular method.℗l In documenting ĺltried and testedĺl procedures, this book will be invaluable for both established neurosurgeons and residents in neurosurgery.
  • Digital
    Gadryn Christopher Higgs.
    Digital2013
    With each heart contraction, blood rushes throughout the expansive circulatory system providing oxygen and other nutrients to the body. Cardiomyocytes are the contractile units responsible for these contractions. In the event of ischemia, the heart reduces its contractile output and loses a significant number of cardiomyocytes. In the ischemic region of the heart, the tissue remodels and the mechanical properties differ significantly from healthy tissue. Due to the limited regeneration capabilities of the heart, recent focus has been on understanding how the reintegration of pluripotent-derived cardiomyocytes can help restore contractile function. These pluripotent-derived cardiomyocytes will need to survive in mechanically active environments and contribute to the contractile output of the heart. However, even before these cardiomyocytes can be used, we need to develop an understanding for how primary immature cardiomyocytes should respond to mechanical forces in vitro. This work explores cardiomyocyte contractile ability in the presence of mechanical forces. For this work, we investigate neonatal murine cardiomyocytes. We begin by developing a protein patterning technique suitable for polyacrylamide. With this technique, we achieve repeatable arrays of neonatal cardiomyocytes and control their shape and size. We found this technique improves sarcomere distribution, making them look more mature and like adult cardiomyocytes. Using micro-tools, we then investigate cardiomyocyte contractility in the presence of mechanical forces. These findings suggest that the Frank-Starling law that governs the heart is also applicable to neonatal cardiomyocytes. Later in this work, we introduce the MEMS tool developed to better understand cardiomyocyte contractile forces. We describe the design goals and fabrication process of the micro-device. In addition, we present the calibration and testing results, and demonstrate that this device provides a reliable and alternative way to calibrate substrates used to study contractile forces. In the closing section of this work, we introduce ideas for future studies building on this work, and the work of others.
  • Digital
    volume editors, Kimitaka Kaga, Hirotaka Asato.
    Digital : Karger2014
    "Remarkable progress in the development of new concepts and techniques used in reconstructive surgery of microtia/atresia of the external auditory canal (EAC) has been made since the beginning of the 21st century. Helical computed tomography has made a three-dimensional reconstruction of the soft tissue of the temporal bone surface and the cranium possible, and has laid the groundwork for a collaboration between plastic surgeons and otologists. This book presents the latest findings on reconstructive surgery performed jointly by plastic surgeons and otologists. Based on this concept, information on diagnosis, surgical procedures, outcomes, long-term results and psychology is discussed. Collaborative surgery offers advantages not only in terms of a better reconstruction of morphology and function, but also in terms of the lower number of surgical procedures required which reduces the psychological pressure and economic burden on patients."--Publisher's website.
  • Digital
    edited by Anne Straube.
    Digital : Springer Protocols2011
    How to measure microtubule dynamics? / Anne Straube -- Purification of tubulin from porcine brain / Christopher Gell [and others] -- Purification of tubulin from the fission yeast Schizosaccharomyces pombe / Douglas R. Drummond [and others] -- Generation of differentially polyglutamylated microtubules / Benjamin Lacroix and Carsten Janke -- Preparation of pure tyrosinated or detyrosinated tubulin isoforms / Laurence Lafanechère and Didier Job -- [alpha][beta]-tubulin and microtubule-binding assays / Jaime N. Campbell and Kevin C. Slep -- Analysis of microtubule assembly kinetics using turbidimetry / Felicia Gaskin -- Isolation of centrosomes from cultured cells / Simone Reber -- Preparation of dual-color polarity-marked fluorescent microtubule seeds / Miho Katsuki, Etsuko Muto, and Robert A. Cross -- Reconstitution and quantification of dynamic microtubule end tracking in vitro using TIRF microscopy / Ivo A. Telley, Peter Bieling, and Thomas Surrey -- Force generation by dynamic microtubules in vitro / Svenja-Marei Kalisch, Liedewij Laan, and Marileen Dogterom -- Variations on the single-molecule assay for microtubule-associated proteins and kinesins / Susanne Bechstedt [and others] -- Analysing the ATP turnover cycle of microtubule motors / Claire T. Friel, Clive R. Bagshaw, and Jonathon Howard -- Cryo-electron tomography of microtubules assembled in vitro from purified components / Frédéric M. Coquelle [and others] -- Kinetochore microtubules, analyzed by correlated light and immunoelectron microscopy / Andreas Merdes and Jan De Mey -- Photoactivatable-GFP-[alpha]-tubulin as a tool to study microtubule plus-end turnover in living human cells / Catarina P. Samora and Andrew D. McAinsh -- Quantification of asymmetric microtubule nucleation at subcellular structures / Xiaodong Zhu and Irina Kaverina -- Investigating microtubule dynamic instability using microtubule-targeting agents / Stéphane Honore and Diane Braguer -- Laser ablation of the microtubule cytoskeleton : setting up and working with an ablation system / Nicola Maghelli and Iva M. Tolić-Nørrelykke -- Isolation, identification, and validation of microtubule-associated proteins from Drosophila embryos / Robin Antrobus and James G. Wakefield -- Isolation of novel +TIPs and their binding partners using affinity purification techniques / Ka Lou Yu [and others].
  • Digital
    edited by Jun Zhou.
    Digital : Springer Protocols2007
  • Digital
    Irene Adaugo Onyeneho.
    Digital2014
    Stable Tubule Only Polypeptides or STOP proteins are a class of microtubule-associated proteins that are unique in that they have been shown to protect microtubules from depolymerization under destabilizing conditions. To date, MAP6 and the related protein MAP6 domain containing 1 (MAP6D1) are the only known mammalian STOP related proteins. However, through a recent screen identifying genes upregulated during ciliogenesis in multiciliated tracheal cells, we have identified two new uncharacterized mammalian MAP6 related proteins, FAM154A and FAM154B. Though MAP6 has not been previously shown to localize to the primary cilium and centrosome, we sought to assess the ability of these new proteins to stabilize microtubules and their potential function at the cilium and centrosome. Proteins related to FAM154A and FAM154B are found in all vertebrates and most organisms containing cilia and centrosomes including drosophila and chlamydomonas. A C. elegans homolog of the protein has been localized to neuronal cilia and mammalian FAM154B, much like MAP6 is expressed in mammalian cortical neurons. Overexpressed FAM154A and FAM154B localize to the centrosome and the primary cilium and overexpressed FAM154A protein and deletion variants stabilize microtubules against cold treatment in RPE1 cells. Endogenous FAM154A and FAM154B localize to centrosomal structures and cilia respectively in multi-ciliated cells. Similar to MAP6, FAM154A and Fam154B also contain repeated motifs in their amino acid sequences, however their protein level similarity to MAP6 is very limited. We have shown that FAM154A is a bona-fide microtubule associated protein via biochemical assays and can interact directly with microtubules and with calcium calmodulin which may modulate its microtubule binding affinity, similar to MAP6. Ongoing work to resolve the molecular structure of these MAP6 related proteins will illuminate their exact mechanism of microtubule stabilization.
  • Digital
    edited by John J. Correia, Leslie Wilson.
    Digital : ScienceDirect2013
    Site-specific fluorescent labeling of tubulin / Kamalika Muhkerjee, Susan L. Bane -- Measuring microtubule persistence length using a microtubule gliding assay / Douglas S. Martin -- Structural studies of the doublecortin family of MAPs / Frank Fourniol, Mylène Perderiset, Anne Houdusse, Carolyn Moores -- Detection and quantification of microtubule detachment from centrosomes and spindle poles / Anutosh Ganguly, Hailing Yang, Fernando Cabral -- Regulation of tubulin expression by micro-RNAs : implications for drug resistance / Sharon Lobert, Mary E. Graichen -- Determining the structure-mechanics relationships of dense microtubule networks with confocal microscopy and magnetic tweezers-based microrheology / Yali Yang, Megan T. Valentine -- Studying mitochondria and microtubule localization and dynamics in standardized cell shapes / Andrea Pelikan, James Sillibourne, Stephanie Miserey-Lenkei, Frederique Carlier-Grynkorn, Bruno Goud, Phong T. Tran -- Going solo : measuring the motions of microtubules with an in vitro assay for TIRF microscopy / Kris Leslie, Niels Galjart -- Analysis of microtubules in isolated axoplasm from the squid giant axon / Yuyu Song, Scott T. Brady -- Imaging GTP-bound tubulin : from cellular to in vitro assembled microtubules / Hélène de Forges, Antoine Pilon, Christian Poüs, Franck Perez -- Tubulin-specific chaperones : components of a molecular machine that assembles the ... heterodimer / Guoling Tian, Nicholas J. Cowan -- Heterotrimeric G proteins and microtubules / Witchuda Saengsawang, Mark M. Rasenick -- Purification and biophysical analysis of microtubule-severing enzymes in vitro / Juan Daniel Diaz-Valencia, Megan Bailey, Jennifer L. Ross -- Measurement of in vitro microtubule polymerization by turbidity and fluorescence / Matthew Mirigian, Kamalika Mukherjee, Susan L. Bane, Dan L. Sackett -- Live-cell imaging of microtubules and microtubule-associated proteins in arabidopsis thaliana / Jessica Lucas -- Investigating tubulin posttranslational modifications with specific antibodies / Maria M. Magiera, Carsten Janke -- Purification and assembly of bacterial tubulin BtubA/B and constructs bearing eukaryotic tubulin sequences / José M. Andreu, María A. Oliva -- Microtubule-associated proteins and tubulin interaction by isothermal titration calorimetry / P.O. Tsvetkov, P. Barbier, G. Breuzard, V. Peyrot, F. Devred -- Methods for studying microtubule binding site interactions : zampanolide as a covalent binding agent / Jessica J. Field, Enrique Calvo, Peter T. Northcote, John H. Miller, Karl-Heinz Altmann, José Fernando Díaz -- Studying kinetochore-fiber ultrastructure using correlative light-electron microscopy / Daniel G. Booth, Liam P. Cheeseman, Ian A. Prior, Stephen J. Royle -- Fluorescence-based assays for microtubule architecture / Susanne Bechstedt, Gary L. Brouhard -- Structure-function analysis of yeast tubulin / Anna Luchniak, Yusuke Fukuda, Mohan L. Gupta -- Using MTBindingSim as a tool for experimental planning and interpretation / Julia T. Philip, Aranda R. Duan, Emily O. Alberico, Holly V. Goodson -- Imaging individual spindle microtubule dynamics in fission yeast / Judite Costa, Chuanhai Fu, Viktoriya Syrovatkina, Phong T. Tran.
  • Digital
    edited by Leslie Wilson, John J. Correia.
    Digital : ScienceDirect2010
    sect. I. Isolation and biochemistry of tubulin and characterization of antibodies and isotypes -- Preparation of microtubule protein and purified tupbulin from bovine brain by cycles of assembly and disassembly and phosphocellulose chromatography / Herbert P. Miller, Leslie Wilson -- Isolating tubulin from nonneural sources / Dan L. Sackett, Karl A. Werbovetz, Naomi S. Morrissette -- Characterization of anti-B-tubulin antibodies / Anthony J. Spano, Anthony Frankfurter -- Expression profliing of tubulin isotypes and microtubule-interacting proteins using real-time polymerase chain reaction / Sharon Lobert, Laree Hiser, John J. Correia -- Nondenaturing electrophoresis as a tool to investigate tabulin complexes / Monica Lopez Fanarago... [et al.] -- Mass spectrometry analysis of c-terminal postranslational modifications of tubulins / Virginie Redeker -- Methods in tubulin proteomics / Leah M. Miller... [et al.] -- sect. II. Microtubule structure and dynamics -- Cryo-em studies of microtubule structural intermediates and kinetochore-microtubule interactions / Eva Nogales, Vincent H. Rame, Hong-Wei Wang -- High-resolution imaging of microtubules and cytoskeleton structures by atomic force microscopy / Loic Hamon, Patrick A. Curmi, David Patre -- Using computational modeling to understand microtubule dynamics : a primer for cell biologists / Holly V. Goodson, Ivan V. Gregoretti -- Analysis of dynamic instability of steady-state microtubules in vitro by video-enchanced differential interference contrast microscopy with an appendix by Emin Oroudjev / Mythili Yenjerla, Manu Lopus, Leslie Wilson -- Nanometer-resolution microtubule polymerization assays using optical tweezers and microfabricated barriers/ Blake d. Charlebois, Henry T. Schek III, Alan J. Hunt -- Microtubule dynamics reconstituted in vitro and imaged by single-molecule fluorescence microscopy / Christopher Gell... [et al.] -- Studying kinesin motors by optical 3D-nanometry in gliding motility assays / Bert Nitzsche... [et al.] -- sect. III. Drugs -- Analysis of tubulin oligomers by analytical ultricentrifugation / John J. Correia -- Determination of drug binding to mactrotubules in vitro / Jennifer A. Smith, Mary Ann Jordan -- Fluorescence spectroscopic methods to analyze drug-tubulin interactoins / Bhabatarak Bhattacharyya, Sonia Kapoor, Dulal Panda -- Tubulin polymerizatin microassay used to compare ligand eficacy / Ashley Davis... [et al.] -- Fluorescent taxoid probes for microtubule research / Isabel Barasoain, J. Fernando Diaz, Jose M. Andrea -- Binding of vinca domain agents to tubulin : structural and biomedical studies / Anthony Cormier... [et al.] -- Measurement of ligand binding to tubulin by sulfhydryl reactivity / Adrian Begaye, Dan L. Sackett -- sect. IV. Interactions with motors and MAPs -- Probing interactions of tubulin with small molecules, peptides, and protein fragments by solution nuclear magnetic resonance / Marie-Jeanne Clement... [et al.] -- Microtubule and MAPs : thermodynamics of complex formation by AUC, ITC, fluorescence, and NMR / Francois Devred... [et al.] -- Quantitative analysis of MAP-mediated regulation of microtubule dynamic instability in vitro--focus on tau / Erkan Kiris, Donovan Ventimiglia, Stuart C. Feinstein -- Structure and dynamics of the kinesin-Microtubule interaction revealed by fluorescence polarization microscopy / Hernando Sosa, Ana B. Asenjo, Erwin J.G. Peterman -- Multiple collor single molecule TIRF imaging and tracking of MAPs and motors / Jennifer L. Ross, Ram Dixit -- Studying plus-end tracking at single molecule resolution using TIRF microscopy / Ram Dixit, Jennifer L. Ross -- Fluorescence microscopy assays on chemically functionalized surfaces for quantitative imaging of microtubule, motor, and +TIP dynamics / Peter Bieling... [et al.] --
  • Digital
    edited by Lynne Cassimeris and Phong Tran.
    Digital : ScienceDirect2010
  • Digital
    Shi-Ting Li, Jun Zhong, Raymond F. Sekula, Jr., editors.
    Digital : Springer2016
  • Digital
    edited by Ping Liang, Xiao-ling Yu, Jie Yu.
    Digital : Springer2015
    Microwave ablation is a simple, affordable, and highly precise technique. After its successful application in treating liver tumors, it is now widely used to combat renal tumors, adrenal tumors, thyroid nodes, uterine fibroids and other solid tumors. This book presents 40 successful cases of treating these diseases. A series of picture before treatment, after treatment and from different angles is provided for each kind of tumor treatment. In each chapter, step by step operative techniques and illustrations are included. This book also examines CT, NMR and ultrasonography to evaluate the effect of microwave ablation. Editor Ping Liang, is the Director and Professor at Dept. of Interventional Ultrasound, General Hospital of PLA, Beijing, China. Editor Xiaoling Yu is Professor and Chief physician, Editor Jie Yu is Associate Chief physician at the same department.
  • Digital
    Sunil Puria, Richard R. Fay, Arthur N. Popper, editors.
    Digital : Springer2013
    The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scientific and clinical perspectives.
  • Digital
    Henning Hildmann, Holger Sudhoff ; with contributions by Manuel Bernal-Sprekelsen ... [et al.].
    Digital : Springer2006
  • Print
    [edited by] N. Franklin Adkinson, Jr. ... [et al.].
    Printv. 1-2.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Adkinson, N. Franklin; Middleton, Elliott.
    Digital : ClinicalKey2014
  • Digital
    Robyn E. O'Hehir, Stephen T. Holgate, Aziz Sheikh.
    Digital : ClinicalKey2017
    Introduction to mechanisms of allergic diseases -- The origins of allergic disease -- Epidemiology of allergic diseases -- Indoor and outdoor allergens and pollutants -- Principles of allergy diagnosis -- Allergen-specific immunotherapy -- Asthma -- Allergic rhinitis and conjunctivitis -- Drug allergy -- Urticaria and angioedema without wheals -- Atopic dermatitis and allergic contact dermatitis -- Food allergy and gastrointestinal syndromes -- Anaphylaxis -- Occupational allergy -- Insect allergy.
  • Digital
    edited by Cláudio Cardoso de Castro, Kristin A. Boehm.
    Digital : ClinicalKey2009
    Anatomy of the upper and lower eyelids -- Anchoring technique for browlifting -- Correction of upper lid ptosis -- Correction of the tear through deformity with hyaluronic acid -- Lower lid blepharoplasty with fat grafts for correction of the tear though -- No-touch lower blepharoplasty -- Alloplastic augmentation to improve blepharoplasty and midfacial results -- Orbital aging and harmony in orbital rejuvenation -- Evolution of the subperiosteal midface lift -- Midface elevation: one single suture -- Is the transpalpebral approach to the upper and midface rejuvenation a safe method? -- A personal approach to upper and lower blepharoplasty -- Transconjuctival deep-plane midface rejuvenation -- Correction of blepharoplasty complications, management of the elevated upper eylid during blepharoplasty -- Atypical granulomas and infection after blepharoplasty -- Autogenous allogeneic and alloplastic lower lid spacers after blepharoplasty
  • Digital
    Mine Ergüven, Takashi Muramatsu, Ayhan Bilir, editors.
    Digital : Springer2012
    pt. 1. GENERAL ASPECTS OF MIDKINE -- General Information on Midkine / Takashi Muramatsu -- The Role of Midkine in Neural Development and Patterning / Sheng Yao and Christoph Winkler -- Midkine: A Player in Innate Immunity / Sara L. Nordin and Arne Egesten -- Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition / Yiping Huang and Edward A. Ratovitski -- Immunochemical Methods for the Detection of Midkine in Samples of Human Origin / Stefan Sommerschuh, Michael Kirchner and Nicole Gliese -- Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review / Malgorzata Krzystek-Korpacka and Malgorzata Matusiewicz -- pt. 2. MIDKINE AND INFLAMMATION -- Midkine in Inflammation and Inflammatory Diseases / Nuray Yazıhan, Mehtap Kacar Kocak and Ethem Akcıl -- Rheumatoid Arthritis and Midkine / Hisako Muramatsu, Kiyoko Maruyama and Naoki Ishiguro -- pt. 3. MIDKINE AND THE CARDIOVASCULAR SYSTEM -- Midkine and Heart Failure / Mitsuru Horiba and Kenji Kadomatsu -- Vascular Restenosis and Midkine / Kenji Kadomatsu -- The Potential of MK Through the Renin-Angiotensin System / Tomoki Kosugi and Kenji Kadomatsu -- pt. 4. MIDKINE AND THE NERVOUS SYSTEM -- Midkine and Multiple Sclerosis / Hideyuki Takeuchi -- Midkine Gene Transfer in Brain Infarction / Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita and Yasuhiro Kumai -- Midkine in Psychiatric and Neurodegenerative Diseases / Eiji Shimizu and Daisuke Matsuzawa -- pt. 5. MIDKINE AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGING -- Role of Midkine in Nephrogenesis and Kidney Disease / Waichi Sato and Kenji Kadomatsu -- Midkine, a Factor Promoting Cytoplasmic Maturation of Oocytes / Masayasu Yamada, Yuuki Isaji and Shuntaro Ikeda -- Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles / Yutaka Osuga, Yasushi Hirota, Kaori Koga, Osamu Yoshino and Tetsuya Hirata -- Stem Cells and Midkine / Hisako Muramatsu, Peng Zou and Takashi Muramatsu -- Midkine in Skeletal Physiology / Astrid Liedert, Thorsten Schinke, Anita Ignatius and Michael Amling -- pt. 6. MIDKINE AND CANCER -- Midkine and Chemoresistance in Cancers / Yoshifumi Takei and Kenji Kadomatsu -- A Gene Medicine with the Midkine-mediated Transcriptional Regulation as New Cancer Therapeutics / Masatoshi Tagawa, Kiyoko Kawamura, Ling Yu, Yuji Tada and Kenzo Hiroshima, et al. -- Midkine as a Tumor-Shared Antigen / Jerome Kerzerho, Florence Anne Castelli and Bernard Maillère -- Midkine in Prostate Cancer / Zongbing You -- Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma / Li Cheng Dai, Xing Yao and Jing Zhong -- Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival / Mine Ergüven and Ayhan Bilir -- Colon Cancer and Midkine / Özgür Kemik, Ahu Sarbay Kemik and A. Cumhur Dülger -- Osteosarcoma and Midkine / Tadashi Kaname, Kumiko Yanagi and Hiroki Maehara.
  • Digital
    Paolo Cappabianca, Luigi Maria Cavallo, Oreste de Divitiis, Felice Esposito, editors.
    Digital : Springer2016
    Preface -- Acknowledgements -- Part I Pituitary adenomas -- 1 Introduction to pituitary adenomas -- 2 Endoscopic endonasal transsphenoidal approach (standard and extended technique) -- 3 Endoscopic endonasal ethmoid-pterygoid transsphenoidal approach to the cavernous sinus -- 4 Frontotemporal approach -- 5 Radiotherapy and radiosurgery -- Part II Craniopharyngiomas -- 6 Introduction to craniopharyngiomas -- 7 Endoscopic endonasal transsphenoidal approach -- 8 Frontotemporal approach -- 9 Supraorbital approach -- 10 Transcallosal approach -- 11 Radiotherapy and radiosurgery for craniopharyngiomas -- Part III Cystic sellar lesions -- 12 Introduction to cystic sellar lesions -- 13 Arachnoid cysts -- 14 Rathke cleft cyst -- Part IV Anterior cranial fossa meningiomas -- 15 Introduction to anterior cranial fossa meningiomas -- 16 Endoscopic endonasal transsphenoidal approach -- 17 Frontotemporal approach -- 18 Subfrontal approach -- 19 Supraorbital approach -- 20 Radiotherapy and radiosurgery -- Part V Clival chordomas -- 21 Introduction to clival chordomas -- 22 Endoscopic endonasal transsphenoidal approach -- 23 Retrosigmoid approach -- 24 Skull base approaches -- 25 Radiotherapy, radiosurgery and proton beam -- Part VI Cranial base reconstruction after transcranial and transnasal skull base surgery -- 26 Indications for cranial base reconstruction -- 27 Neuroradiology in cranial base reconstruction -- 28 Anatomy of cranial base reconstruction -- 29 Techniques for cranial base reconstruction.
  • Print
    Richard Bucala, Jürgen Bernhagen, editors.
    Print2017
    Status: Not Checked OutLane Catalog Record
    MIF and CD74-dependent Mechanisms -- HSP90-stabilized MIF in Oncogenesis and Cell Growth Control- CD74, MIF, and Breast Tumorigenesis: Insights from Recent Large-scale Tumor Genomics and Proteomics Studies -- MIF-dependent Regulation of Monocyte/Macrophage Polarization -- Advances in understanding the role of MIF in the pathogenesis of autoimmune diseases -- Role of MIF in Experimental Autoimmune Encephalomyelitis and Multiple Sclerosis -- Role of MIF in Hepatic Inflammatory Diseases and Fibrosis -- MIF and Pulmonary Disease -- MIF Mediates Pelvic Inflammation and Pain -- MIF Family Proteins in Cardiac Ischemia / Reperfusion Injury -- The MIF-CD74 Inflammatory Axis in Alphaviral Infection -- MIF in Eosinophilic Inflammation -- The Role of MIF in Parasitic Infections -- Parasite MIF Orthologs.
  • Digital
    David W. Dodick, Stephen D. Silberstein.
    Digital : Oxford Medicine Online2016
    Print2016
    Diagnosis -- Genetics -- Less common migraine subtypes -- Migraine comorbidity -- Migraine pathogenesis -- Non- pharmacologic therapy -- Acute migraine therapy -- Preventative treatment -- Chronic migraine -- Neuromodulation -- Hormones.
  • Digital
    edited by C. Overy and E.M. Tansey.
    Digital : Wellcome Trust2014
  • Digital
    Eric Le Bourg , Suresh I.S. Rattan, editors.
    Digital : Springer2008
  • Digital
    edited by John Y.M. Koo, Ethan C. Levin, Argentina Leon, Jashin J. Wu, Mark G. Lebwohl,.
    Digital : CRCnetBASE2014
    General approach to psoriasis treatment / Laura F. Sandoval and Steven R. Feldman -- General guidelines for administration of topical agents / Shannon Famenini, Eric Y. Sako, and Jashin Wu -- Topical corticosteroids / Laura F. Sandoval and Steven R. Feldman -- Vitamin D3 analogs / Argentina Leon, Chai Sue Lee, and John Y.M. Koo -- Fixed dose corticosteroid/calcipotriene combination therapy / Ethan Levin and John Y.M. Koo -- Tazarotene / Monica Huynh, Chai Sue Lee, and John Y.M. Koo -- Topical calcineurin inhibitors / Mark G. Lebwohl and Chrystal A. Landry -- Coal tar, anthralin, salicyclic acid, and lactic acid / Sarah Fitzmaurice and John Y.M. Koo -- Topical sequential therapy / Rishu Gupta and John Y.M. Koo -- Phototherapy and laser / Mio Nakamura, Holly A. Kerr, and Iltefat Hamzavi -- Combination therapy / Maya G. Debbaneh and Alice Gottlieb -- Palmoplantar psoriasis / Daniel C. Butler and April Armstrong -- Scalp psoriasis / Peter C.M. van de Kerkhof, Marloes M. Kleinpenning, and Rianne M.J.P. Gierritsen -- Inverse psoriasis / Lara Wine-Lee, Robert A. Lee, and Abby S. Van Voorhees -- Psoriasis of the nails / Ashley A. Keyes, Richard K. Scher, Gabrielle B. Poindexter, Maithily A. Nendedkar-Thomas.
  • Digital
    [edited by] Ara Kanekanian, Cardiff Metropolitan University, UK.
    Digital : Wiley2014
    The health benefits of bioactive compounds from milk and dairy products -- Bioactive peptides from casein and whey proteins -- Colostrum : Its health benefits -- Casein and whey proteins in human health -- Sports nutrition and dairy products -- Dairy fat : Perceptions and realities -- Milk ingredients as functional foods -- Milk-derived bioactive components from fermentation -- Minerals and vitamins in milk and dairy products -- Legislations and relevant regulations.
  • Digital
    editors, Roger A. Clemens, Olle Hernell, Kim Fleischer Michaelsen.
    Digital : Karger2011
    The role of milk during the life cycle - a global view
  • Digital
    editors, J. Bánóczy, P.E. Persen, A. J. Rugg-Gunn.
    Digital : WHO2009
    Print2009
    1. Milk, nutrition and human health / A. J. Rugg-Gunn and P. E. Petersen -- 2. Clinical studies / J. Bánóczy and A.J. Rugg-Gunn -- 3. Basic science studies / W. M. Edgar -- 4. The addition of fluoride to milk / A. E. Villa -- 5. The Implementation of community based programmes / S. M. Woodward -- 6. Evaluating fluoride exposure in milk fluoridation programmes / A. E. Villa -- 7. Programme evaluation / P. E. Petersen and A. J. Rugg-Gunn -- 8. Conclusions
  • Digital
    [edited by] Ronald D. Miller ; associate editors, Neal H. Cohen, Lars I. Eriksson, Lee A. Fleisher, Jeanine P. Wiener-Kronish, William L. Young.
    Digital : ClinicalKey2015
  • Print
    edited by Ronald D. Miller ; associate editors, Lars I. Eriksson, Lee A Fleisher, Jeanine P. Wiener-Kronish, William L. Young.
    Printv. 1-2.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Alan Weiss.
    Digital : ProQuest Ebook Central2012
    Business vows : what is a proposal and why it is necessary -- Five steps toward great leaps : how to prepare yourself and the client -- Avoiding gatekeepers, intermediaries, and goblins : accepting rejection and rejecting acceptance -- The architecture of successful proposals : the million dollar consulting proposal structure -- One dozen golden rules for presenting proposals : steak and sizzle are hard to beat -- Why bad things happen to good people who wait : moving mountains -- First, let's kill all the lawyers : Shakespeare really meant that we needed them -- The dreaded RFP (request for proposals) : why fill out the truly boring in triplicate? -- Retainers are to projects as Montrachet is to Thunderbird : the wonder of access to your smarts -- In the unlikely event you need oxygen : we don't anticipate a crash, but there are some things you ought to know.
  • Digital
    Richard V. Goering, Hazel M. Dockrell, Mark Zuckerman, Peter L. Chiodini, Ivan M. Roitt.
    Digital : ClinicalKey2013
    Using a clinically relevant, systems-based approach, this medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Richard Goering makes this complex subject simple to understand and remember. 150 multiple choice review questions. "Pathogen Parade" and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way. Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
  • Digital
    Liah Greenfeld.
    Digital : ProQuest Ebook Central2013
    In the culminating volume of her nationalism trilogy, Greenfeld argues that we have overlooked the connection between egalitarian society and mental illness. Modern nationalism rests on principles of popular sovereignty, equality, and secularism. Citizens of the twenty-first century enjoy unprecedented freedom to become the authors of their personal destinies. Empowering as this is, it also places them under enormous psychic strain. They must constantly appraise their identities, manage their desires, and calibrate their place within society. For vulnerable individuals, this pressure is too much. Training her analytic eye on extensive case histories in manic depression and schizophrenia, Greenfeld contends that these illnesses are dysfunctions of selfhood caused by society's overburdening demands for self-realization. In her rigorous diagnosis, madness is a culturally constituted malady.
  • Digital
    edited by Markus Raab, Joseph G. Johnson, Hauke R. Heekeren.
    Digital : ScienceDirect2009
  • Digital
    Patricia Lynn Dobkin, editor.
    Digital : Springer2015
    Chapter 1. Introduction: Mindful Medical Practice -- Chapter 2. Mindful Rounds, Narrative Medicine, House Calls and Other Stories -- Chapter 3. Lost Heart(beat)/Broken(body) -- Chapter 4. Working with Groups Mindfully -- Chapter 5. The Opera of Medicine -- Chapter 6. The Mindful Psychiatrist: Being Present with Suffering -- Chapter 7. The Death of a Snowflake -- Chapter 8. Carmen's Story -- Chapter 9. A Mindful Life in Medicine: One Pediatrician's Reflections on Being Mindful -- Chapter 10. Embodied Wisdom: Meeting Experience through the Body -- Chapter 11: Minding Baby Abigale -- Chapter 12. Mindfulness in Oncology: Healing Through Relationship -- Chapter 13. Choosing to Survive: A Change in Reproductive Plans -- Chapter 14. Mindfulness in the Realm of Hungry Ghosts -- Chapter 15. In the Heart of Cancer -- Chapter 16. Hiking on the Eightfold Path -- Chapter 17. Strengthening the Therapeutic Alliance Through Mindfulness: One Nephrologist's Experiences -- Chapter 18. Richard's Embers -- Chapter 19. Mindful Decisions in Urogynecological Surgery: Paths from Awareness to Action -- Chapter 20. The Good Mother -- Chapter 21. I Am My Brother's Keeper -- Chapter 22. The Mindful Shift -- Chapter 23. Lifeline -- Chapter 24. Medical Students' Voices: Reflections on Mindlessness During Clinical Encounters -- Chapter 25. Growth and Freedom in 5 Chapters -- Chapter 26. A Wounded Healer's Reflections on Healing -- Chapter 27. Mindfulness, Presence and Whole Person Care -- Chapter 28. Mindful Attitudes Open Hearts in Clinical Practice -- Index.
  • Digital
    Trish Bartley.
    Digital : Wiley2016
  • Digital
    Diane R. Gehart.
    Digital : Springer2012
    Mindfulness in Therapy -- A Mindful Re-visioning of Couple and Family Therapy Practice -- Mindfulness Research Foundations -- Therapeutic Presence and Mindfulness -- Mindfulness-Informed Case Conceptualization and Treatment Planning -- Teaching Mindfulness Practice in Therapy -- Foundational Mindfulness- and Acceptance- Informed Interventions and Practices -- Mindfulness and Acceptance Interventions for Couples and Families -- Training and Supervision -- Therapist Self-Care and Style of Life.
  • Digital
    Michiel van Vreeswijk, Jenny Broersen, Ger Schurink.
    Digital : Wiley2014
    Theoretical background -- Introduction -- Schema therapy -- Mindfulness -- Training manual -- Framework -- Contraindications -- Training -- Pitfalls -- Conclusion -- Appendix: -- Part iii" participant workbook -- Participant workbook -- Appendix: homework sheets.
  • Digital
    Stuart J. Eisendrath, editor.
    Digital : Springer2016
    Chapter 1. Introduction -- Part I. MBCT for Medical Conditions -- Chapter 2. Pain -- Chapter 3. Diabetes -- Chapter 4. Traumatic Brain Injury -- Chapter 5. Gynecologic Cancer -- Chapter 6. Headache -- Chapter 7. Unexplained Symptoms -- Chapter 8. Urologic Cancer -- Chapter 9. Cardiac -- Chapter 10. Inflammatory Bowel Disease -- Chapter 11. HIV -- Part II. MBCT for Psychiatric Conditions -- Chapter 12. Perinatal Depression -- Chapter 13. Relapse Prevention -- Chapter 14. Panic Disorder -- Chapter 15. Treatment Resistant Depression -- Chapter 16. Generalized Anxiety -- Chapter 17. Perinatal Anxiety -- Chapter 18. Dysthymia -- Chapter 19. OCD -- Chapter 20. Bipolar -- Chapter 21. PTSD -- Chapter 22. Suicidal Behavior.
  • Digital
    Richard W. Sears and Kathleen M. Chard.
    Digital : Wiley2016
  • Digital
    edited by Ruth A. Baer.
    Digital : ScienceDirect2006
  • Digital
    Gerhard Zarbock, Siobhan Lynch, Axel Ammann, Silka Ringer.
    Digital : Wiley2015
    Welcome -- Mindfulness -- Week 1: Introduction to Mindfulness -- Week 2: The five elements of mindfulness -- Week 3: Integrating mindfulness into every day life -- Week 4: Mindfulness as a way of life -- Week 5: Mindfulness as a home base for therapists -- Week 6: Mindfulness of the body -- Week 7: Integrating mindfulness into therapeutic practice -- Week 8: Review and next steps -- Week 9: Your Oasis -- Extending your practice -- Exercises in everyday personal and professional lives -- Mindfulness exercises for the helping role -- Mindful moments with your clients -- Short Manual for running a group based on the presented material.
  • Digital
    Bruno A. Cayoun.
    Digital : Wiley2015
  • Digital
    edited by Rosaria Conte, Giulia Andrighetto, Marco Campennì.
    Digital : OSO2014
    Norms are prescribed conducts applied by the majority of people. Getting across cultures and centuries, norms evolved to rule all human relationships, from the most formal to the most intimate. Impinging on any sphere of life, from religious to political, norms affect social, moral, and even aesthetical behaviours. They are enforced through centralized sanctions or distributed control, and originate through deliberate acts of issuing or from spontaneous interaction in informal settings. Despite ubiquity and universality, norms are still awaiting for a general comprehensive theory, simultaneously doing justice to three intuitions: that, under variable contents, norms correspond to a common notion; that, once brought about, norms feedback on their producers, affecting their conducts; and finally that before and in order to drive the behaviours of individuals, norms must affect their beliefs and goals: people must detect and accept norms before converting them into observable behaviours. This volume presents an unprecedented attempt to account for all the three intuitions at once, providing a systematic view of norms. Based on a unitary and operational notion of norms, as behaviours spreading thanks to and to the extent that the corresponding prescriptions spread as well, a cognitive architecture, EMIL-A, which is the main output of a research project on norm emergence, is described. EMIL-A is a BDI-like platform for simulation, endowed with modules for detecting, reasoning and deciding upon norms. Next, the EMIL-A platform is applied to generate norms in different simulated scenarios (from a multi-setting world to a virtual Wikipedia), through a complex bidirectional dynamics, i.e., the bottom-up emergence of norms thanks to a gradual, top-down process, denoted as immergence. As simulations results show, norms emerge while immerging in agents' minds, thanks to their detecting, reasoning, and deciding whether to respect them or not.
  • Digital
    edited by Piotr Szefer, Jerome O. Nriagu.
    Digital : CRCnetBASE2007
    Mineral components in food: analytical implications / M. Biziuk, J. Kuczynska -- Speciation of mineral components in food: analytical implications / A. Polatajko, J. Szpunar -- Criteria of evaluation of food trace analysis data / B. Szteke -- Chemometric techniques in analytical evaluation of food / P. Szefer -- Functional role of some minerals in foods / M. Nabrzyski -- Mineral components and their species in foods of animal origin and honeys / P. Szefer, M. Grembecka -- Mineral components and their species in plant foods, beverages, luxury food, spices and dietary food / P. Szefer, M. Grembecka -- Trace elements in wines / S. Galani-Nikolakaki, N. Kallithrakas-Kontos -- Heavy metals in food packagings / M. E. Conti -- Pollutants in food: metals and metalloids / C. Reilly -- Pollutants in food: radionuclides / Z. Oul-Dada -- Assessment of exposure to chemical pollutants in food and water / P.J. Peterson -- Metal contamination of dietary supplements / M.J. Slotnick, J.O. Nriagu.
  • Print
    edited by C.L. Comar, Felix Bronner.
    Status: Not Checked OutLane Catalog Record
    v. 1. Principles, processes, and systems. 2 pts. -- v. 2. The elements. 2 pts -- v. 3. Calcium physiology.
  • Digital
    edited by Dr. Mahmoud Torabinejad.
    Digital : Wiley2014
    Pulp and periradicular pathways, pathosis, and closure / Mahmoud Torabinejad -- Chemical properties of mineral trioxide aggregate / David W. Berzins -- Physical properties of mineral trioxide aggregate / Lawrence Gettleman and Ricardo Caicedo -- Use of MTA in vital pulp therapy / Till Dammaschke, Joe Camp, and George Bogen -- Use of MTA in teeth with necrotic pulps and open apices / Shahrokh Shabahang and David Witherspoon -- Use of MTA in regenerative endodontics / Mahmoud Torabinejad, Robert P. Corr, and George T.J. Huang -- Use of MTA as root perforation repair / Mahmoud Torabinejad and Ron Lemon -- Root canal obturation with MTA / George Bogen, Ingrid Lawaty, and Nicholas Chandler -- Use of MTA as root end filling / Seung-Ho Baek and Su-Jong Shin -- Calcium silicate-based cements / Masoud Parirokh and Mahmoud Torabinejad.
  • Digital
    editors, Laurie K. McCauley, Martha J. Somerman.
    Digital : Wiley2012
  • Print
    Williams, Ralph C.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Dominique G. Poitout, Henri Judet, editors.
    Digital : Springer2014
    In recent years, mini-invasive surgery has become increasingly important for reducing the risk of infection and minimizing blood loss and volume of implants. Hip surgery requires small incisions, which make the use of the appropriate equipment and an extensive knowledge of the anatomy of the region essential. Mini-invasive surgery requires the surgeon to consider the indications for surgery for each patient he treats and to know the exact loco-regional anatomy for that patient. Methods must be very precise and warrant visual explanations to help teach young surgeons.
  • Digital
    Kunal Kumar Ghosh.
    Digital2010
    Fluorescence microscopy has emerged as a workhorse of modern biology and medicine. Fluorescence microscopes are indispensable as tools for basic research in the biological sciences, enable platforms for drug discovery in the biotechnology and pharmaceutical industries, and are increasingly aiding in several clinical diagnostic applications. However, state-of-the-art fluorescence microscopes remain bulky and expensive benchtop instruments with an architecture that impedes usage in certain applications and a cost that precludes adoption in large numbers. For example existing benchtop fluorescence microscopes are not amenable for in vivo imaging in animals, with the mouse being a common animal subject, especially during awake, active behavior. For the field of neuroscience in particular, such an experimental capability permits correlating causal cellular processes with animal behavior -- a longstanding goal. Inspired by this need, we have designed a miniature fluorescence microscope that can be borne by a mouse during active behavior. We have fabricated several such microscopes, each less than 2 g in mass, perhaps heralding a transformation in fluorescence microscopy from today's bulky and expensive benchtop paradigm towards miniature and mass-producible devices. Our fabricated microscopes achieve 2.5 μm spatial resolution imaging fields-of-view up to 800 μm x 600 μm at 36 Hz, suitable for cellular-level imaging at high temporal resolution. To facilitate design of our microscopes, we have adopted a modeling-based microscope design methodology, akin to that used in the design of integrated circuits, and have developed a set of tools to model the microscope as an integrated device from the specimen to final digital image. We have experimentally validated fabricated microscopes for in vivo brain imaging in freely behaving mice, specifically using them for: 1) Imaging cerebellar vasculature and hemodynamics during activity; and 2) Imaging cerebellar Purkinje cell Calcium dynamics, analyzing spiking activity of populations of neurons with single neuron specificity during different motor behaviors. We also show how several of these microscopes imaging in parallel can enable new high-throughput imaging solutions with the potential to achieve broad impact, specifically demonstrating high-throughput image-based assays for: 1) Mutant phenotype screening in genetic model species such as the zebrafish; and 2) Multiple well plate cell analyses. Finally, we use a Bayesian iterative image restoration algorithm to enhance acquired microscope images, and show how spatial resolution can be further scaled into the sub-micron regime by leveraging advances in digital image sensing technology in conjunction with our post-acquisition image restoration algorithm.
  • Digital
    Michail Ignatiadis, Christos Sotiriou, Klaus Pantel, editors.
    Digital : Springer2012
    Part 1. Introduction -- Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer: Open Questions for Research / Michail Ignatiadis, Christos Sotiriou and Klaus Pantel -- Part 2. Minimal residual disease and breast cancer metastasis -- Self-Seeding in Cancer / Elizabeth Comen and Larry Norton -- Microenvironments Dictating Tumor Cell Dormancy / Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso -- Part 3. Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization -- Immunomagnetic Separation Technologies / Astrid E. L. M. Hoeppener, Joost F. Swennenhuis and Leon W. M. M. Terstappen -- Microfluidic Technologies / Ali Asgar. S. Bhagat and Chwee Teck Lim -- EPISPOT Assay: Detection of Viable DTCs/CTCs in Solid Tumor Patients / Catherine Alix-Panabières -- Advances in Optical Technologies for Rare Cell Detection and Characterization / Lou Dietz and Richard Bruce -- Size-Based Enrichment Technologies for CTC Detection and Characterization / Anthony Williams, Marija Balic, Ram Datar and Richard Cote -- Emerging Technologies for CTC Detection Based on Depletion of Normal Cells / Maryam Lustberg, Kris R. Jatana, Maciej Zborowski and Jeffrey J. Chalmers -- Molecular Assays for the Detection and Characterization of CTCs / Evi S. Lianidou and Athina Markou -- Multiplex Molecular Analysis of CTCs / Anieta M. Sieuwerts and Stefanie S. Jeffrey -- Part 4. Other blood-based biomarkers / Circulating DNA and Next-Generation Sequencing -- Susanna Cooke and Peter Campbell -- Circulating MicroRNAs as Noninvasive Biomarkers in Breast Cancer / Maria Angelica Cortez, James William Welsh and George Adrian Calin -- Circulating Endothelial Cells and Circulating Endothelial Progenitors / Patrizia Mancuso, Angelica Calleri and Francesco Bertolini -- Part 5. Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in breast cancer clinical research and practice -- DTCs in Breast Cancer: Clinical Research and Practice / W. Janni, Brigitte Rack, N. Kasprowicz, C. Scholz and P. Hepp -- CTCs in Primary Breast Cancer (I) / Brigitte Rack, Ulrich Andergassen, Wolfgang Janni and Julia Neugebauer -- CTCs in Primary Breast Cancer (II) / E. Saloustros and D. Mavroudis -- CTCs in Metastatic Breast Cancer / Antonio Giordano and Massimo Cristofanilli -- HER2-Positive DTCs/CTCs in Breast Cancer / Andreas D. Hartkopf, Malgorzata Banys and Tanja Fehm -- DTCs/CTCs in Breast Cancer: Five Decades Later / Susan Alsamarai, Maysa M. Abu-Khalaf and Lyndsay N. Harris -- Part 6. Drug and circulating tumor cell co-development -- Challenges in Drug and Biomarker Co-Development / Sheila E. Taube and Tracy Lively -- Challenges and Opportunities in the Use of CTCs for Companion Diagnostic Development / Elizabeth A. Punnoose and Mark R. Lackner.
  • Digital
    Gautam N. Allahbadia, Markus Nitzschke, editors.
    Digital : Springer2015
    This contributed volume regenerates the significance of and respect for natural phenomenon in the background of the risks and complications seen in ART such as ovarian hyperstimulation and multiple pregnancies. Balancing the clinical practice between the beneficial natural physiology and the prolific use of stimulation drugs for ART may help eliminate risks that may prove clinically, financially and psychologically expensive. It underscores the fact that 'greater' is not always synonymous with 'better' with regard to the oocyte yield. While highlighting the risks involved with the use of high-dose gonadotropins, the book presents a stratification of patients who might benefit from the 'soft' minimal and natural cycle IVF stimulation protocols that may be used. Additionally, clinicians can understand the significance of cryopreservation technology, now a useful adjunct to minimal stimulation protocols, with its manifold future advantages. Written by an international team of experts, this handbook emphasizes how minimal stimulation and natural cycle IVF can lead to a milder, safer and more effective approach to ART. .
  • Digital
    edited by David J. Terris, Michael C. Singer.
    Digital : Springer2014
    "Minimally Invasive and Robotic Thyroid and Parathyroid Surgery is the first textbook which includes a comprehensive review of both minimally invasive and robotic thyroid and parathyroid techniques. Over the last several years there has been a rapid expansion in the number of different surgical approaches available to patients undergoing thyroid and parathyroid surgery. This book consolidates these in one source and focuses on both the philosophy and techniques of these procedures. For thyroid surgery, the text covers the full range of minimally invasive procedures and several of the most widely adopted remote access techniques. Several related procedures are also discussed, including minimally invasive approaches to central and lateral neck dissection. For parathyroid surgery, several minimally invasive techniques are covered, including radioguided surgery. Written by experts in the field of thyroid and parathyroid surgery, Minimally Invasive and Robotic Thyroid and Parathyroid Surgery serves as a critical resource for both experienced and less experience surgeons, fellows, residents, and students interested in understanding the breadth of this field or learning the specific steps of a particular technique."--Publisher's website.
  • Digital
    Howard M. Ross, Sang W. Lee, Matthew G. Mutch, David E. Rivadeneira, Scott R. Steele, editors.
    Digital : Springer2015
    Part I. Preoperative -- 1. Perioperative Assessment / Charlotte Kvasnovsky and Andrea Chao Bafford -- 2. Patient Positioning, Instrumentation, and Trocar Placement / Mehraneh Dorna Jafari, Michael J. Stamos, and Steven Mills -- 3. Surgical Anatomy / Todd D. Francone and Ron G. Landmann -- Part II. Procedures -- 4. Right Colectomy: Straight Laparoscopic / Steven Robert Hunt -- 5. Right Colectomy: Hand-Assist / Kirk A. Ludwig and Timothy Ridolfi -- 6. Laparoscopic Sigmoidectomy/Left Colectomy / Toyooki Sonoda -- 7. Hand-Assisted Left Colectomy / Steven Lee-Kong and Daniel L. Feingold -- 8. Total Abdominal Colectomy: Straight Laparoscopic Approach / Amanda V. Hayman and Eric J. Dozois -- 9. Total Abdominal Colectomy: Hand- Assisted Approach / Kiyokazu Nakajima, Tsunekazu Mizushima, and Riichiro Nezu -- 10. Operative Details of Laparoscopic Rectal Resection for Cancer / Martin R. Weiser -- 11. Laparoscopic Hand-Assisted Low Anterior Resection / Govind Nandakumar and Sang W. Lee -- 12. Laparoscopic Abdominoperineal Resection / Jennifer S. Davids and Justin A. Maykel -- 13. Laparoscopic Proctocolectomy / David A. Etzioni and Tonia M. Young-Fadok -- 14. Laparoscopic Rectopexy / Mia DeBarros and Scott R. Steele -- 15. Minimally Invasive Approach for Stoma Creation / Seth I. Felder, Zuri Murrell, and Phillip Fleshner -- 16 Laparoscopic Stoma Reversal / Emre Gorgun -- 17. Laparoscopic Parastomal Hernia Repair / Joshua A. Tyler and Matthew G. Mutch -- Part III. Technical Challenges and Tips -- 18. Overcoming Technical Challenges: The Abdomen / Eric K. Johnson -- 19. Overcoming Technical Challenges: The Pelvis / M. Shane McNevin -- 20. Overcoming Technical Challenges: Reoperative Surgery / Brian R. Englum, M. Benjamin Hopkins, and John Migaly -- 21. Overcoming Technical Challenges: Prevention and Managing Complications / Bradley R. Davis -- Part IV. New Horizons -- 22. Single-Incision Laparoscopic Approaches to Colorectal Disease / Virgilio George -- 23. Natural Orifice Surgery (NOTES) / Mark H. Whiteford -- 24. Robotic Surgery /Mehraneh Dorna Jafari, David E. Rivadeneira, and Alessio Pigazzi -- 25. Transanal Minimally Invasive Surgery (TAMIS): Operative Technique, Pitfalls, and Tips / Francisco Quinteros, Kumaran Thiruppathy, and Matthew R. Albert -- 26. Combined Endo-Laparoscopic Surgery (CELS) / Kelly A. Garrett and Sang W. Lee -- Part V. Special Situations -- 27. Emergent Laparoscopic Colorectal Surgery / Rodrigo Pedraza and Eric M. Haas -- 28. Laparoscopy in the Elderly Patient / Joshua I. S. Bleier and Brian R. Kann -- 29. Laparoscopic Colectomy in the Obese Patient / Arida Siripong and H. David Vargas -- 30. Minimally Invasive Surgery in Crohn's Disease Patients / Chang Sik Yu -- 31. Minimally Invasive Surgery in Ulcerative Colitis Patients / Marco E. Allaix and Alessandro Fichera -- 32. Minimally Invasive Approaches to Colon and Rectal Diseases: Technique and Best Practices--Pediatrics / Eric J. Krebill and Daniel J. Robertson -- 33. Laparoscopy in Pregnant Patients / Melissa M. Alvarez-Downing and David J. Maron -- 34. Economics of Laparoscopic Colectomy / Anthony J. Senagore -- 35. Outcomes of Laparoscopic Surgery / Jennifer Leahy and Rocco Ricciardi -- Part VI. Conclusions -- 36. Future Directions in Minimally Invasive Surgery / Howard M. Ross and Matthew Miller Philp.
  • Digital
    Marcello Lucchese, Nicola Scopinaro, editors.
    Digital : Springer2015
    This book explains the concept of metabolic surgery and provides step-by-step descriptions of all the principal minimally invasive surgical techniques employed to treat morbid obesity. The approach adopted is very practical. For each procedure, indications, technical aspects, clinical management, and outcomes are described, and helpful tips and tricks, highlighted. Guidance is provided on the management of emergencies and potential complications, as well as on general postoperative management and long-term follow-up. The coverage also includes new frontiers of robotic and endoscopic surgery. While the focus is on surgical techniques, emphasis is placed on the need for a multidisciplinary approach, with explanation of the role of the multidisciplinary team and the bariatric center. In addition, important information is presented on the definition of morbid and severe obesity, incidence/prevalence, pathophysiology, and obesity-related comorbidities. The authors are internationally acknowledged experts who present best practice know-how in the field and draw on the most recent research literature.
  • Digital
    editors: Stacy A. Brethauer, Philip R. Schauer, Bruce D. Schirmer.
    Digital : Springer2015
    The second edition of Minimally Invasive Bariatric Surgery provides a comprehensive, state-of-the art review of this field, and it serves as a valuable resource for clinicians, surgeons and researchers with an interest in minimally invasive bariatric surgery. Additionally, the second edition includes new features that will benefit the resident, fellow, or bariatric surgeon new to the field. Specifically, each evidence-based chapter (i.e. outcomes, complications, epidemiology, etc) concludes with three or four exam questions that emphasize the salient points of the chapter and provide fellowship programs a valuable training tool and resource for their academic curriculum. These questions are either single-answer multiple choice or true/false format and the correct response with a brief explanation follows. As more emphasis is placed on completing a comprehensive curriculum and obtaining certification for bariatric training, this aspect of the book is unique and provides added value to the text. The new edition also incorporates many new or updated medical illustrations to enhance the technique chapters and provide more uniformity for the artwork throughout the book. Each of the major procedures include surgical technique, outcomes, and management of complications in separate chapters to provide an easy reference for the busy clinician preparing for a case or presentation. Another unique feature of the text is a link to video files hosted online for the relevant chapters. This video library will be of great value to the user. As the number of fellowships in laparoscopic bariatric surgery continues to increase, this updated text will provide a valuable resource for general and bariatric surgeons, laparoscopic surgeons, fellows, residents, medical students, obesity researchers, and industry representatives involved in this field. Minimally Invasive Bariatric Surgery is a valuable resource for Medical students, surgical oncology fellows, general surgeons, and educators.
  • Digital
    Renzo Brun del Re (ed.).
    Digital : Springer2009
  • Digital
    F.L. Greene, B.T. Heniford (eds.).
    Digital : Springer2010
    As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.
  • Digital
    William C.S. Meng, Hester Y.S. Cheung, David T.Y. Lam, Simon S.M. Ng, editors.
    Digital : Springer2015
  • Digital
    edited by Farzad R. Nahai, Foad Nahai.
    Digital : ClinicalKey2009
    Botox® cosmetic / Alan Matarasso, David Shafer -- Chemical peels / Richard H. Bensimon -- Radiofrequency ablation for the reduction of glabellar frowning / James Newman -- Dermabrasion . Farzad R. Nahai -- Wire dissection to correct facial rhytids / Miles H. Graivier -- Use of barbed sutures in the face / Malcolm D. Paul -- Facial rejuvenation with structural fat grafting / Alesia P. Saboeiro, Sydney R. Coleman / Necklift vs neck rejuvenation / Patrick K. Sullivan, Erik A. Hoy -- Short-scar facelift / Alexis M. Verpaele, Patrick L. Tonnard -- Endoscopic brow lift / Renato Saltz, Mark A. Codner -- Treatment of the superficial musculo-aponeurotic system during minimally invasive facial rejuvenation / Salvatore J. Pacella, Farzad Nahai, Mark A. Codner -- Limited Incision midface lift / Oscar M. Ramirez. DVD Contents: Clinical uses of Botox® / Alan Matarasso, David M. Shafer -- Trichloracetic acid chemical peel / Mark A. Codner -- Croton oil peel / Richard H. Bensimon -- Dermabrasion / Farzad R. Nahai -- Wire dissection to correct facial rhytids / Miles H. Graivier -- Submental dissection /Farzad R. Nahai -- Short scar facelift / Foad Nahai -- Endoscopic browlift / Mark A. Codner -- Limited incision midface lift / Oscar M. Ramirez.
  • Digital
    Nicola Maffuli, Mark Easley, editors.
    Digital : Springer2013
    Minimally Invasive Forefoot Surgery in Clinical Practice describes a number of the better established and accepted minimally invasive surgical correction techniques for forefoot problems, and is aimed at junior and general orthopedic surgeons who require a useful easy reference for these procedures.The concise written text is complemented by a generous assortment of useful photos, diagrams, and imaging studies.
  • Digital
    Steven N. Hochwald, editor ; Moshim Kukar, associate editor.
    Digital : Springer2015
    This book provides detailed, comprehensive and illustrative content to the surgical community in the areas of foregut oncologic surgery. The text contains an in-depth review of all surgical aspects of oncologic diseases involving the stomach and esophagus. The main focus is on the minimally invasive techniques including potential complications and their management. The text also includes an online link to the videos for all minimally invasive foregut surgical procedures, including animation content which provide a more comprehensive learning experience. Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice is structured in a way that makes it useful at every level of training and will be of great utility to practicing surgeons, fellows in surgical subspecialty training and surgical residents.
  • Digital
    Olav Istre, editor.
    Digital : Springer2015
  • Digital
    T. Kanno (editor in chief), Y. Kato ( ed.).
    Digital : Springer2006
  • Digital
    I. Howard Fine, Daniel S. Mojon (eds.).
    Digital : Springer2010
    Minimally invasive oculoplastic surgery / Michèle Beaconsfield and Richard Collin -- Minimally invasive conjunctival surgery / Shigeru Kinoshita ... [et al.] -- Minimally invasive lacrimal surgery / Rainer K. Weber -- Minimally invasive corneal surgery / Heather M. Skeens and Edward J. Holland -- Minimally invasive refractive surgery / Jorge L. Alio, Mohamad Rosman, and Samuel Arba Mosquera -- Minimally invasive strabismus surgery / Daniel S. Mojon -- Minimally invasive iris surgery / Roger F. Steinert -- Minimally invasive glaucoma surgery / Elie Dahan ... [et al.] -- Minimally invasive cataract surgery / I. Howard Fine, Richard S. Hoffman, and Mark Packer -- Minimally invasive vitreoretinal surgery / Loh-Shan Leung, Woo Ho Nam, and Stanley Chang.
  • Digital
    [edited by] Daniel H. Kim, Yong-Chul Kim, Kyung-Hoon Kim.
    Digital : ClinicalKey2011
    Daniel H. Kim, MD, FACS, Kyung Hoon Kim, MD, and Yong Chul Kim, MD, helps you apply methods of spinal pain relief that involve less risk and shorter recovery times. Focusing on the broad appeal of this goal for you and your patients, this volume will help surgeons and specialists in various areas of pain management provide less invasive alternatives and faster recovery procedures for those suffering with spinal injuries. Step-by-step techniques are well-illustrated in the book and demonstrated extensively on DVD. Reduce the risk associated with invasive spinal procedures by considering new perspectives on pain management techniques that can be used by specialists from various disciplines. Address the growing need for less invasive surgeries with shorter recovery times among a large and aging population with musculoskeletal problems. You and your patients both want less invasive, less risky options for faster recovery & better outcomes.
  • Digital
    edited by Stephen K. Harrel, Thomas G. Wilson, Jr.
    Digital : Wiley2015
    Overview of minimally invasive therapy / Stephen K. Harrel and Thomas G. Wilson, Jr. -- Visualization for minimally invasive periodontal therapy : an overview / Stephen K. Harrel -- Ultrasonic endoscopic periodontal debridement / John Y. Kwan and Suzanne Newkirk -- Endoscope use in daily hygiene practice / Kara Webb and Angela Anderson -- The use of the dental endoscope and videoscope for diagnosis and treatment of peri-implant diseases / Thomas G. Wilson, Jr. -- Development of minimally invasive periodontal surgical techniques / Stephen K. Harrel -- The MIS and V-MIS surgical procedure / Stephen K. Harrel -- Minimally invasive surgical technique (MIST) and modified-MIST (M-MIST) in periodontal regeneration / Dott Pierpaolo (Sandro) Cortellini -- MI soft tissue grafting / Edward P. Allen and Lewis C. Cummings -- Future potential for minimally invasive periodontal therapy / Stephen K. Harrel and Thomas G. Wilson, Jr.
  • Digital
    Michael Wang, Yi Lu, Praveen Mummaneni, D. Greg Anderson, editors.
    Digital : Springer2014
    Contemporary spinal surgeons, whether orthopedic or neurosurgeons, are increasingly recognizing minimally invasive spine surgery (MISS) as a valuable option for managing advanced degenerative diseases. MISS techniques minimize blood loss and surgical site pain, while speeding recovery. Thus, the combination of MISS with adult spinal deformity was a natural choice. Currently, the techniques, technologies, and education of surgeons have finally reached a point where MISS deformity surgeries are becoming commonplace. Nevertheless, the field is young enough (and still evolving) that no comprehensive texts have addressed the unique challenges it poses for surgeons. This book fills that gap.
  • Digital
    Burak Ozgur, Edward Benzel, Steven Garfin, editors.
    Digital : Springer2009
  • Digital
    H.M. Mayer (ed.).
    Digital : Springer2006
    A minimally invasive open approach for reconstruction of the anterior column of the thoracic and lumbar spine / B. Knowles ... [et al.] -- Percutaneous vertebroplasty in osteoporotic vertebral fractures / G.M. Hess, H.M. Mayer -- Microsurgical open vertebroplasty and kyphoplasty / B.M. Boszczyk ... [et al.] -- Percutaneous kyphoplasty in traumatic fractures / G. Maestretti, P. Otten -- Lumbar spine. Low back pain. Inteventional and semi-invasive procedures for low back pain and disc herniation / M.K. Schäufele -- Disc. Intradiscal electrothermal therapy / J. Saal -- Microtherapy in low back pain / A.T. Yeung, C.A. Yeung -- Principles of microsurgical discectomy in lumbar disc herniations / H.M. Mayer -- The microsurgical interlaminar, paramedian approach / H.M. Mayer -- The translaminar approach / L. Papavero -- General. Minimally invasive spine surgery / H.M. Mayer -- Technological advances of surgical microscopes for spine surgery / W. Rulffes -- Spinal microsurgery: a short introduction / H.M. Mayer -- Microsurgical instruments / A. Korge -- Operating room setup and handling of surgical microscopes / K. Wiechert -- Computer-assisted minimally invasive spine surgery - state of the art / F. Langlotz, L.P. Nolte -- Cervical spine. Odontoid. Technique of transoral odontoidectomy / P.J. Apostolides ... [et al.] -- Microsurgical treatment of odontoid fractures / P. Klimo Jr., G. Rao, R.I. Apfelbaum -- Disc surgery/decompression. Microsurgery of the cervical spine: the anterior approach / L. Papavero -- Anterior cervical foraminotomy (microsurgical and endoscopic) / W.F. saringer -- Functional segmental reconstruction with the Bryan cervical disc prosthesis / J. Goffin -- Microsurgical total cervical disc replacement / H.M. Mayer -- Microsurgical posterior approaches to the cervical spine / P.H. Young, J.P. Young, J.C. Young -- Microsurgical C1 - 1 stabilization / D. Fassett, R.I. Apfelbaum -- Thoracic/thoracolumbar spine. General techniques. Microsurgical anterior approach to T5 - 10 (Mini-TTA) / H.M. Mayer -- Microsurgical anterior approach to the thoracolumbar junction / H.M. Mayer -- Anatomic principles of thoracoscopic spine surgery / U. Liljenqvist -- Principles of endoscopic techniques to the thoracic and lumbar spine / G.M. McCullen, A.A. Criscitiello, H.A. Yuan -- Biomechanical requirements in minimally invasive spinal fracture treatment / M. Schultheiss ... [et al.] -- Deformities. Thoracoscopic approaches in spinal deformities and trauma / M. Dufoo-Olvera -- Thoracoscopic techniques in spinal deformities / D. Sucato -- Mini-open endoscopic excision of hemivertebrae / R. Stücker -- Fractures. Thoracoscopically assisted anterior approach to thoracolumbar fractures / R. Beisse -- Spinal stenosis. Microsurgical decompresssion of acquired (degenerative) central and lateral spinal canal stenosis / H.M. Mayer -- Fusion. Microsurgical anterior lumbar interbody fusion (Mini-ALIF): the lateral retroperitoneal approach to L2/3, L3/4, and L4/5 / H.M. Mayer -- Microsurgical anterior lumbar interbody fusion (Mini-ALIF): the transperitoneal approach to L5/S1 / H.M. Mayer -- Minimally invasive 360° lumbar fusion / M. Aebi -- The anterior extraperitoneal video-assisted approach to the lumbar spine / M. Onimus, H. Chataigner -- Dynamic stabilization. Minimally invasive dynamic stabilization of the lumbar motion segment with an interspinous implant / J. Sénégas -- Technical and anatomical considerations for the placement of a posterior interspinous stabilizer / J. Taylor, S. Ritland -- Elastic microsurgical stabilization with a posterior shock absorber / S. Caserta, G.A. La Maida, B. Misaggi. The lateral, extraforaminal approach / L. Papavera -- Transforaminal endoscopic discectomy / J. Krugluger -- Microscopically assisted percutaneous technique as a minimally invasive approach to the posterior spine / R. Greiner-Perth, H. Boehm, E. El Saghir -- Arthroscopic and endoscopic spine surgery via a posterolateral approach / P. Kambin -- The full-endoscopic interlaminar approach for lumbar disc herniations / S. Ruetten -- Outpatient microsurgical lumbar discectomy and microde-compression laminoplasty / R.S. Biscup, V. Podichetty -- Disc reconstruction. Nucleus reconstruction by autologous chondrocyte transplantation / H.-J. Meisel, T. Ganey -- Autologous disc chondrocyte transplantation / F. Grochulla, H.M. Mayer, A. Korge -- The ALPA approach for minimally invasive nucleus pulposus replacement / R. Bertagnoli -- Mini-open midline accesses for lumbar total disc replacement / H.M. Mayer --
  • Digital
    Frank M. Phillips, Isador H. Lieberman, David W. Polly, Jr., editors.
    Digital : Springer2014
    Over the past decade, minimally invasive techniques have developed rapidly and are widely applied in the management of spine disorders. With the development of enabling technologies, including specifically designed spinal retractor systems, intra-operative imaging and navigation technologies, and real-time neural monitoring, minimally invasive spine surgery (MISS) techniques are safe, effective and reproducible. Indeed, studies have confirmed the clinical and economic advantages of these procedures. Minimally Invasive Spine Surgery includes detailed discussions of enabling technologies, surgical techniques (including posterior decompression and fusion), approaches to specific diseases and conditions, as well as strategies to manage the unique risks and complications of MISS. Generously illustrated, this will be an essential reference for orthopedic surgeons, neurosurgeons and all health care professionals who treat the spine.
  • Digital
    [edited by] Roger Härtl, Andreas Korge.
    Digital : Thieme eNeurosurgery2012
  • Digital
    Nicola Maffuli, Mark Easley, editors..
    Digital : Springer2013
    Minimally Invasive Surgery for Achilles Tendon Disorders in Clinical Practice is a collection of procedures presented by experts and pioneers in foot and ankle surgery who share an interest in developing less invasive methods of treating disorders of the foot and ankle. The rate of complications of traditional surgery is extremely high: in the management of tendinopathy, traditional techniques result in 10% of patients experiencing a complication related to skin healing. It is therefore not surprising that less invasive techniques have been advocated.This book will serve as an excellent pocket reference when repairing disorders of the Achilles and aimed general orthopedic surgeons and specialist who require a useful easy reference for these procedures.
  • Digital
    Giles R. Scuderi, Alfred J. Tria, editors.
    Digital : Springer2010
  • Digital
    Giles R. Scuderi, Alfred J. Tria, editors.
    Digital : Springer2016
  • Digital
    J. Pfeil, W.E. Siebert (eds.).
    Digital : Springer2010
    Introduction / Joachim Pfeil -- Anatomy of the Hip Joint / Joachim Pfeil -- Complications / Joachim Pfeil -- Patient Selection, Indications and Contraindications / Joachim Pfeil -- The Anterior Approach / Etienne Lesur -- The Anterolateral Approach with the Patient in Lateral Position / Werner Siebert -- The Anterolateral Approach with the Patient in Supine Position / Joachim Pfeil -- The Posterior Approach / Modaine J -- Epilogue / Werner Siebert.
  • Digital
    edited by Nicola Maffulli and Mark E. Easley.
    Digital : Springer2011
    Minimally invasive foot surgery: a paradigm shift -- Computer-assisted surgery (CAS) in foot and ankle surgery -- Tendoscopy -- Arthroscopy of the first metatarsophalangeal joint -- Minimally invasive management of hallux rigidus -- Percutaneous first metatarso-phalangeal joint fusion -- The Reverdin-Isham procedure for the correction of hallux valgus: a distal metatarsal osteotomy procedure using minimal invasive technique -- Arthroscopic assisted correction of hallux valgus deformity -- Minimally invasive hallux valgus correction -- Minimally invasive modified Wilson osteotomy for the treatment of hallux valgus -- Percutaneous surgery for static metatarsalgia -- Percutaneous treatment of static metatarsalgia with distal metatarsal mini-invasive osteotomy -- Isham hammertoe procedures for the correction of lesser digital deformities -- Minimally invasive management of dorsiflexion contracture at the metatarsophalangeal joint and plantarflexion contracture at the proximal interphalangeal joint of the fifth toe -- Arthroscopic assisted correction of lesser toe deformity -- Percutaneous fixation of proximal fifth metatarsal fractures -- Minimally invasive realignment surgery of the charcot foot -- Arthroscopic triple arthrodesis -- Percutaneous calcaneal displacement osteotomy -- Tendoscopy of the flexor halluces longus tendon -- Open reduction and internal fixation of calcaneal fractures through a combined medial and lateral approach using a small incision technique -- Endoscopic plantar fasciotomy -- Arthroscopic Os trigonum excision -- Endoscopic calcaneoplasty -- Postero-medial approach in the supine position for posterior ankle endoscopy -- Ankle equinus and endoscopic gastrocnemius recession -- Athroscopic arthrodesis of the ankle -- Percutaneous osteosynthesis of distal tibial fractures using locking plates -- Percutaneous supramalleolar osteotomy using the Ilizarov/Taylor spatial frame -- Minimally invasive management of syndesmotic injuries -- Endoscopic assisted percutaneous Achilles tendon repair -- Percutaneous repair of acute Achilles tendon ruptures -- Minimally invasive semitendinosus tendon graft augmentation for reconstruction of chronic tears of the Achilles tendon -- Minimally invasive Achilles tendon reconstruction using the peroneus brevis tendon graft -- Free hamstrings tendon transfer and interference screw fixation for less invasive reconstruction of chronic avulsions of the Achilles tendon -- Percutaneous longitudinal tenotomies for chronic Achilles tendinopathy -- Minimally invasive stripping for chronic Achilles tendinopathy.
  • Digital
    Fulvio Calise, Luciano Casciola, editors.
    Digital : Springer2013
    The treatment of liver diseases comprises a significant component of the practice of any general surgeon, whether working in an academic, a general, or a community hospital. With the rapid expansion in knowledge and technology, the liver has also been approached laparoscopically in specialized centers, with well-recognized advantages for patients. This book aims to communicate the large body of experience that has now been accumulated in minimally invasive liver surgery, with comprehensive and up-to-date information on the newest techniques. After a concise description of the main tools and technology necessary to carry out safe laparoscopic and/or robot-assisted liver surgery, individual operative techniques are explained and illustrated. Each chapter includes introductory information, a summary of indications and contraindications, and a detailed description of surgical procedure, including potential complications of both the surgery and the postoperative care. Special efforts have been taken to ensure that the illustrations are accurate and informative. The text is supplemented by a DVD of different procedures as performed by leading European liver surgeons.
  • Digital
    Pier Paolo Maria Menchetti, editor.
    Digital : Springer2014
    Minimally invasive procedures are increasingly utilized and are replacing open surgery to reduce scarring and pain, enhance patient recovery, and minimize cost. This guide provides step-by-step guidance, expert instruction, and detailed illustration of the most recent minimally invasive orthopedic spine procedures. With a variety of chapters covering critical developments in the field including the utilization of biologic materials, image-guided surgery, and bone fusion, this guide delves into discussions of indications, methods for preoperative planning, complication avoidance strategies.
  • Digital
    Ronald Matteotti, Stanley W. Ashley (editors).
    Digital : Springer2011
    The past 20 years have witnessed an extraordinarily rapid adoption of minimally invasive surgical techniques, and increasingly these techniques are being employed in the diagnosis and treatment of a wide range of malignancies. This book is designed to serve as a unique and comprehensive overview of the current status of minimally invasive surgery in oncology patients and in addition offers valuable insights into the future of this constantly evolving field. The first section of the book is devoted to essential background information and to explaining what is physiologically distinctive in the cancer patient undergoing laparoscopic surgery. The second section then examines in detail a wide range of clinical aspects and issues across different disciplines, with clear instruction on the use of minimally invasive procedures. The aim is to enable the reader to make treatment decisions appropriate to the individual patient, to carry them out effectively, and to institute suitable postoperative care. Summaries of the latest knowledge in traditional therapies such as chemotherapy are also provided when appropriate. Each chapter is written by a recognized expert, and numerous high-quality illustrations are included to assist understanding. This book will serve both as a clinical reference guide and as an operative atlas, and is certain to prove invaluable in daily clinical practice.
  • Digital
    Celestino Pio Lombardi, Rocco Bellantone, editors.
    Digital : Springer2016
    1. Ultrasound features of thyroid, parathyroid, neck lymph nodes: normal and pathologic pattern -- 2. Fine needle aspiration biopsy -- 3. Cytology of thyroid lesions -- 4. Molecular markers in thyroid fine-needle aspiration biopsises -- 5. Percutaneous ethanol injection for the management of thyroid lesions -- 6. Percutaneous laser thermal ablation (LAT): techniques, indications, experience, and complications -- 7. Percutaneous radiofrequency ablation -- 8. High-intensity focused ultrasound ablation (Hi-FU) in endocrine neck diseases -- 9. Mini-invasive techniques for the treatment of thyroid nodules: critical issues -- 10. Minimally invasive video-assisted thyroidectomy (MIVAT) -- 11. Locoregional anesthesia in thyroid and parathyroid surgery -- 12. Robotic thyroidectomy -- 13. Minimally invasive video-assisted parathyroidectomy (MIVAP) -- 14. Endoscopic parathyroidectomy -- 15. Minimally invasive video-assisted neck dissection -- 16. Minimally invasive surgical techniques: critical appraisal and future perspectives -- 17. Superior laryngeal nerve monitoring -- 18. Recurrent laryngeal nerve monitoring -- 19. Hemostatic devices -- 20. Topical hemostatic agents -- 21. Critical appraisal -- 22. How to avoid and manage post-operative complications -- 23. Perioperative medical treatment -- 24. Patient counselling and patients' involvement in health policy.
  • Digital
    Gopal H. Badlani, editor.
    Digital : Springer2014
    "Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse provides a detailed insight into "when, why, what and how" of various minimally invasive surgical procedures for surgical management of SUI, OAB & POP. The volume provides detailed diagrammatic and pictorial step-by-step descriptions of the techniques and management of complications related to these procedures. This book also presents an up to date, one-stop reference for anything pertaining to MIT of these pelvic disorders. Written by experts in the field, Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse is a comprehensive resource designed for both the urologist and urogynecologist treating patients with urinary disorders and pelvic organ prolapsed, as well as for residents in training."--Publisher's website.
  • Digital
    Rolf Gilbert Carl Inderbitzi, Ralph Alexander Schmid, Franca M.A. Melfi, Roberto Pasquale Casula, editors.
    Digital : Springer2012
    Part I. Minimally invasive thoracic surgery, general -- Part II. Minimally invasive thoracic surgery, the lung -- Part III. Minimally invasive thoracic surgery, the pleura -- Part IV. Minimally invasive thoracic surgery, the mediastinum -- Part V. Minimally invasive thoracic surgery, chest wall -- Part VI. Minimally invasive thoracic surgery, the oesophagus -- Part VII. Minimally invasive thoracic surgery, the diaphragm -- Part VIII. Minimally invasive cardiac surgery, general -- Part IX. Minimally invasive cardiac surgery, the heart -- Index.
  • Digital
    Dimitrios Linos, Woong Youn Chung, editors.
    Digital : Springer2012
    This book describes in detail the various techniques of minimally invasive thyroidectomy that have emerged in recent years and presents the new supportive equipment, including intraoperative monitoring and energy devices. In addition, the basic preoperative techniques that are a prerequisite to successful thyroidectomy are covered, and individual chapters are devoted to complications, outcomes, and post-thyroidectomy quality of life. Important related topics are also discussed, including guidelines for managing papillary and medullary thyroid cancer and the surgical management of metastatic lymph nodes. Both the editors and the authors are internationally renowned experts, and they include the founders of several of the techniques described. The up-to-date text is supplemented by many color pictures and medical illustrations, making the book very user-friendly and ideal for the busy surgeon or endocrinologist who is interested in the management of thyroid diseases.
  • Digital
    C. Stroszczynski (ed.).
    Digital : Springer2006
    Print2006
  • Digital
    Sara L. Best, Stephen Y. Nakada, editors.
    Digital : Springer2015
  • Digital
    Jorge L. Alió, I. Howard Fine, eds.
    Digital : Springer2010
    Introduction: Minimizing: A Continuous Trend in Cataract Surgery / I. Howard Fine, Jorge Alio, Mark Packer, Richard S. Hoffman and Peter Allan Karth -- The Transition Towards Smaller and Smaller Incisions: Micro-Coaxial Phacoemulsification with Torsional Ultrasound / James M. Osher and Robert H. Osher -- Transitioning to Bimanual MICS / Rosa Braga-Mele -- 0.7 mm Microincision Cataract Surgery / Jorge L. Alió, Amar Agarwal and Pawel Klonowski -- MICS Instrumentation / Jorge L. Alió, Pawel Klonowski and Jose L. Rodriguez-Prats -- Evolution of Ultrasound Pumps and Fluidics and Ultrasound Power: From Standard Coaxial Towards the Minimal Incision Possible in Cataract Surgery / William J. Fishkind -- Coaxial Microincision Cataract Surgery Utilizing Non-Linear Ultrasonic Power: An Alternative to Bimanual Microincision Cataract Surgery / Stephen S. Lane -- Technology Available: How to Better Use Fluidics with MICS / Rupert Menapace and Silvio Di Nardo -- How to Use Power Modulation in MICS / Randall J. Olson -- MICS with Different Platforms / Arturo Pèrez-Arteaga -- Using the Alcon Infiniti and AMO Signature for MICS / Richard Packard -- MICS with Different Platforms: Stellaris Vision Enhancement System / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Surgical Technique - How to Perform a Smooth Transition / Mark Packer, Jennifer H. Smith, I. Howard Fine and Richard S. Hoffman -- Pupil Dilation and Preoperative Preparation / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Incisions / I. Howard Fine, Richard S. Hoffman and Mark Packer -- Thermodynamics / Alessandro Franchini, Iacopo Franchini and Daniele Tognetto -- Using Ophthalmic Viscosurgical Devices with Smaller Incisions / Steve A. Arshinoff -- Capsulorhexis / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Hydrodissection and Hydrodelineation / I. Howard Fine, Richard S. Hoffman and Mark Packer -- Biaxial Microincision Cataract Surgery: Techniques and Sample Surgical Parameters / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Biaxial Microincision Phacoemulsification: Transition, Techniques, and Advantages / Richard S. Hoffman, I. Howard Fine and Mark Packer -- BiMICS vs. CoMICS: Our Actual Technique (Bimanual Micro Cataract Surgery vs. Coaxial Micro Cataract Surgery) / Jerome Bovet -- Endophthalmitis Prevention / Ayman Naseri and David F. Chang -- Biaxial Microincision Phacoemulsification for Difficult and Challenging Cases / I. Howard Fine, Jorge L. Alió, Richard S. Hoffman and Mark Packer -- MICS in Special Cases: Incomplete Capsulorhexis / Arturo Pérez-Arteaga -- MICS in Special Cases (on CD): Vitreous Loss / Jerome Bovet -- How to Deal with Very Hard and Intumescent Cataracts / L. Felipe Vejarano and L. F. Vejarano -- IOL Types and Implantation Techniques: MICS Intraocular Lenses / Jorge L. Alió and Pawel Klonowski -- Implantation Techniques / T. Amzallag -- Special Lenses: Toric Posterior Chamber Intraocular Lenses in Cataract Surgery and Refractive Lens Exchange / Gerd U. Auffarth, Tanja M. Rabsilber and Miriam Casper -- Special Lenses: MF / Hakan Kaymak and Ulrich Mester -- Special Lenses: Aspheric / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Intraocular Lenses to Restore and Preserve Vision Following Cataract Surgery / Robert J. Cionni and David Hair -- Microincision Intraocular Lenses: Others / Richard S. Hoffman, I. Howard Fine and Mark Packer -- Outcomes: Safety: MICS versus Coaxial Phaco / George H. H. Beiiko Control of Corneal Astigmatism and Aberrations / Jorge L. Alió and Bassam El Kady -- Corneal Endothelium and Other Safety Issues / H. Burkhard Dick -- Incision Quality in MICS / Bassam El Kady and Jorge L. Aliió
  • Digital
    [edited by] David Lo, Siau-Cheng Khoo, Jiawei Han, Chao Liu.
    Digital : CRCnetBASE2011
    1. Specification mining : a concise introduction / David Lo ... [et al.] -- 2. Mining finite-state automata with annotations / Leonardo Mariani ... [et al.] -- 3. Adapting grammar inference techniques to mine state machines / Neil Walkinshaw and Kirill Bogdanov -- 4. Mining API usage protocols from large methods traces / Michael Pradel and Thomas R. Gross -- 5. Static API specification mining : exploiting source code model checking / Mithun Acharya and Tao Xie -- 6. Static specification mining using automata-based abstractions / Eran Yahav ... [et al.] -- 7. DynaMine : finding usage patterns and their violations by mining software repositories / Benjamin Livshits and Thomas Zimmermann -- 8. Automatic inference and effective application of temporal specifications / Jinlin Yang and David Evans -- 9. Path-aware static program analyses for specification mining / Muralikrishna Ramanathan, Ananth Grama, and Suresh Jagannathan -- 10. Mining API usage specifications via searching source code from the Web / Suresh Thummalapenta, Tao Xie, and Madhuri R. Marri -- 11. Merlin : specification inference for explicit information flow problems / Benjamin Livshits ... [et al.] -- 12. Lightweight mining of object usage / Andrzej Wasylkowski and Andreas Zeller.
  • Digital
    edited by Peter A. McAnulty, Anthony D . Dayan , Niels-Christian Ganderup , and Kenneth L . Hastings.
    Digital : CRCnetBASE2012
    Section 1. Origin and management of the minipig -- section 2. Welfare and experimental usage of the minipig -- section 3. Pharmacology and ADME studies in the minipig -- section 4. Safety assessment in the minipig : principal body systems -- section 5. Genetics and immunology -- section 6. Disease models -- section 7. Regulatory perspective and use of the minipig in developing marketed products -- section 8. New horizons and perspectives.
  • Digital
    Ronald J. Prineas, Richard S. Crow, Zhu-Ming Zhang.
    Digital : Springer2010
  • Digital
    Philip Buttaravoli, Stephen M. Leffler.
    Digital : ScienceDirect2012
    Digital : ClinicalKey2012
  • Digital
    edited by Thomas P. Jahn and Gerd P. Bienert.
    Digital : Springer2010
    Print2010
    Aquaporins : a family of highly regulated multifunctional channels / Charles Hachez and François Chaumont -- Phylogeny of major intrinsic proteins / Jonas Å.H. Danielson and Urban Johanson -- Metalloids, soil chemistry, and the environment / Enzo Lombi and Peter E. Holm -- Arsenic transport in prokaryotes and eukaryotic microbes / Barry P. Rosen and Markus J. Tamøs -- Metalloid transport by aquaglyceroporins : consequences in the treatment of human diseases / Rita Mukhopadhyay and Eric Beitz -- Roles of vertebrate aquaglyceroporins in arsenic transport and detoxification / Zijuan Liu -- Molecular mechanisms of boron transport in plants : involvement of arabidopsis NIP5;1 and NIP6;1 / Kyoko Miwa ... [et al.] -- Silicon transporters in higher plants / Jian Feng Ma -- Major intrinsic proteins and arsenic transport in plants : new players and their potential roles / Gerd P. Bienert and Thomas P. Jahn -- Major intrinsic proteins in biomimetic membranes / Claus Hølix Nielsen.
  • Digital
    Francis D. Moore.
    Digital : NAP1995
    Print1995
  • Digital
    edited by Christoph Arenz.
    Digital : Springer Protocols2014
    Part I. Reviews -- Pathway of miRNA maturation / Michael Sand -- MicroRNA maturation and human disease / Marlen Hesse and Christoph Arenz -- Approaches to the modulation of miRNA maturation / Valerie T. Tripp, Jaclyn R. McKenna, and Douglas D. Young -- Part II. Methods -- Expression profiling of components of the miRNA maturation machinery / Michael Sand and Marina Skrygan -- Primary MicroRNA processing assay reconstituted using recombinant Drosha and DGCR8 / Ian Barr and Feng Guo -- In vivo processing assay based on a dual-luciferase reporter system to evaluate DROSHA enzymatic activity / Vera Bilan, Danilo Allegra, Florian Kuchenbauer, and Daniel Mertens -- Assaying dicer-mediated miRNA maturation by means of fluorescent substrates / Marlen Hesse, Brian P. Davies, and Christoph Arenz -- Fluorescence correlation spectroscopy-based enzyme assay for human dicer / Eileen Magbanua and Ulrich Hahn -- Detection of microRNA maturation using unmodified pre-microRNA and branched rolling circle amplification / Saskia Neubacher and Christoph Arenz -- Quantitative RT-PCR specific for precursor and mature miRNAs / Hannah Zöllner, Stephan A. Hahn, and Abdelouahid Maghnouj -- Cellular microRNA sensors based on luciferase reporters / Colleen M. Connelly and Alexander Deiters -- Identification of inhibitors of microRNA function from small molecule screens / Colleen M. Connelly and Alexander Deiters -- Inhibition of miRNA maturation by peptide nucleic acids / Concetta Avitabile, Enrica Fabbri, Nicoletta Bianchi, Roberto Gambari, and Alessandra Romanelli -- Molecular methods for validation of the biological activity of peptide nucleic acids targeting microRNAs / Eleonora Brognara, Enrica Fabbri, Nicoletta Bianchi, Alessia Finotti, Roberto Corradini, and Roberto Gambari -- Lentiviral overexpression of miRNAs / Hannah Zöllner, Stephan A. Hahn, and Abdelouahid Maghnouj.
  • Digital
    edited by Malik Yousef, Dabburiya Village, Israel, Jens Allmer, Izmir Institute of Technology, Izmir, Turkey.
    Digital : Springer Protocols2014
    Introduction to microRNAs in biological systems / Ayse Elif Erson-Bensan -- The role of microRNAs in biological processes / Kemal Uğur Tüfekci, Ralph Leo Johan Meuwissen, and S̮̜ermin Genç -- The role of microRNAs in human diseases / Kemal Uğur Tüfekci [and three others] -- Introduction to bioinformatics / Tolga Can -- MicroRNA and noncoding RNA-related data sources / Patrizio Arrigo -- High-throughput approaches for MicroRNA expression analysis / Bala Gür Dedeoğlu -- Introduction to machine learning / Yalin Baş̧tanlar and Mustafa Özuysal -- Introduction to statistical methods for microRNA analysis / Gökmen Zararsiz and Erdal Coş̧gun -- Computational and bioinformatics methods for microRNA gene prediction / Jens Allmer -- Machine learning methods for microRNA gene prediction / Müş̧erref Duygu Saçar and Jens Allmer -- Functional, structural, and sequence studies of microRNA / Chanchal K. Mitra and Kalyani Korla -- Computational methods for microRNA target prediction / Hamid Hamzeiy, Jens Allmer, and Malik Yousef -- MicroRNA target and gene validation in viruses and bacteria / Debora Baroni and Patrizio Arrigo -- Gene reporter assay to validate microRNA targets in Drosophila S2 cells / Bünyamin Akgül and Çağdaş̧ Göktaş̧ -- Computational prediction of microRNA function and activity / Hasan Oğul -- Analysis of microRNA expression using machine learning / Henry Wirth [and three others] -- MicroRNA expression landscapes in stem cells, tissues, and cancer / Mehmet Volkan Çakir [and three others] -- Master regulators of posttranscriptional gene expression are subject to regulation / Syed Muhammad Hamid and Bünyamin Akgül -- Use of microRNAs in personalized medicine / Çiğir Biray Avci and Yusuf Baran.
  • Digital
    Karen Davis, Kristof Stremikis, David Squires, and Cathy Schoen.
    Digital2014
    "The United States health care system is the most expensive in the world, but comparative analyses consistently show the U.S. underperforms relative to other countries on most dimensions of performance. Among the 11 nations studied in this report --Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the United States -- the U.S. ranks last, as it did in prior editions of Mirror, Mirror. The United Kingdom ranks first, followed closely by Switzerland. Since the data in this study were collected, the U.S. has made significant strides adopting health information technology and undertaking payment and delivery system reforms spurred by the Affordable Care Act. Continued implementation of the law could further encourage more affordable access and more efficient organization and delivery of health care, and allow investment in preventive and population health measures that could improve the performance of the U.S. health care system."--Abstract.
  • Digital
    Giles R. Scuderi, Alfred J. Tria, Richard A. Berger, editors.
    Digital : Springer2006
    Section I. The Shoulder and Elbow -- Mini-Incision bankart Repair for Shoulder Instability / Edward W. Lee and Evan L. Flatow -- Mini-Open Rotator Cuff Repair / Jason A. Schneider and Frances Cuomo -- Mini-Incision Fixation of Proximal Humeral Four-Part Fractures / Jim Hsu and Leesa M. Galatz -- Minimally Invasive Approach for Shoulder Arthroplasty / Theodore Blaine, Ilya Voloshin, Kevin Setter and Louis U. Bigliani --Mini-Incision Medial Collateral Ligament Reconstruction of the Elbow / Steven J. Thornton, Andrew Willis and David W. Altchek -- Mini-Incision Distal Biceps Tendon Repair / Jason A. Schneider and Peter D. McCann -- Section II. The Hip -- A Technique for the Anterolateral Approach to MIS Total Hip Replacement / Richard A. Berger -- The Anterior Approach for Total Hip Replacement: Background and Operative Technique / Joel M. Matta -- Posterolateral Minimal Incision for Total Hip Replacement: Technique and Early Results / Mark A. Hartzband -- Minimally Invasive Total Hip Arthroplasty Using the Two-Incision Approach / Richard A. Berger -- Minimally Invasive Metal-on-Metal Resurfacing Arthroplasty of the Hip / Hari P. Bezwada, Phillip S. Ragland, Craig M. Thomas and Michael A. Mont -- Section III. The Knee: Unicondylar Knee Arthroplasty -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Bone-Sparing Technique / John A. Repicci and Jodi F. Hartman -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Intramedullary Technique / Richard A. Berger and Alfred J. Tria -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Extramedullary Tensor Technique / Paul L. Saenger -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Extramedullary Technique / Giles R. Scuderi -- Minimally Invasive Surgery for Arthroplasty with the UniSpacer / Richard H. Hallock -- Minimally Invasive Technique for Insertion of a Unicompartmental Knee Arthroplasty / A. J. Price and D. W. Murray -- Section IV. The Knee: Total Knee Arthroplasty -- Minimal Incision Total Knee Arthroplasty with a Limited Medial Parapatellar Arthrotomy / Giles R. Scuderi -- Minimally Invasive Total Knee Replacement with the Quadriceps-Sparing Subvastus Approach / Mark W. Pagnano and Giles R. Scuderi -- Mini-Midvastus Total Knee Arthroplasty / Steven B. Haas, Andrew P. Lehman and Mary Ann Manitta -- Minimally Invasive Lateral Approach to Total Knee Arthroplasty / Hari P. Bezwada, Michael A. Mont, Peter M. Bonutti, Phillip S. Ragland and Craig M. Thomas, et al. -- Minimally Invasive Total Knee Arthroplasty Using the Quadriceps-Sparing Approach / Alfred J. Tria -- Section V. Computer Navigation -- Computer-Guided Total Hip Arthroplasty / James B. Stiehl -- Computer-Guided Total Knee Arthroscopy / Alon Wolf, Branislav Jaramaz, Andrew B. Mor and Anthony DiGioia.
  • Digital
    edited by Regina M. Murphy, Amos M. Tsai.
    Digital : Springer2006
  • Digital
    Sabrina Corlette, Sandy Ahn, Kevin Lucia, and Hannah Ellison.
    Digital2016
    The federally facilitated health insurance marketplace (FFM) is attempting to improve consumers' ability to make plan-to-plan comparisons during the 2017 open enrollment season by encouraging insurers to offer standardized benefit designs. In doing so, the FFM is following the path of several state-based marketplaces (SBMs) that require insurers to offer standardized health plans, although the FFM and most SBMs also allow insurers to offer nonstandardized options. Through an analysis of policy guidance, consumer-facing marketplace websites, and interviews with state officials and key stakeholders, this paper explores the experiences of SBMs in Connecticut, Massachusetts, New York, and Oregon that have required participating insurers to offer standardized plans. The authors find that although broad consensus exists among state officials and stakeholders that the primary goal of health plan standardization is to facilitate "apples-to-apples" plan comparisons, these states' policy choices and website interfaces have curtailed their ability to achieve these stated goals. In particular, by allowing insurers to offer nonstandardized options in addition to standardized options and failing to use web-based decision support tools to differentiate between plan options, consumers in these SBMs have limited ability to conduct the plan-to-plan comparisons as originally envisioned by policymakers.
  • Print
    Geert Molenberghs, Michael G. Kenward.
    Print2007
  • Digital
    Michael J. Daniels, Joseph W. Hogan.
    Digital : CRCnetBASE2008
  • Print
    Janet Yikai Jin.
    Print2008
    Status: Not Checked OutLane Catalog Record
  • Print
    Marina Bershteyn.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    Gabriel Aurelio Quiñones.
    Digital2010
    While directed cellular migration facilitates the coordinated movement of cells throughout development, in wound repair, and during an immune response, the precise mechanisms regulating such migration in vivo remain inadequately understood. Missing in Metastasis (MIM) is a defining member of the I-BAR subfamily of lipid binding, actin cytoskeletal regulators whose levels are altered in a number of cancers. Here I provide the first genetic evidence that I-BAR proteins regulate directed cell migration in vivo. MIM regulates the directional migration of several cell types responding to a number of different guidance cues. While regulating the directionality of migrating cells has been demonstrated in vitro, this role of an I-BAR protein in vivo was not previously observed. I demonstrate in these studies that Drosophila MIM (DMIM) is required for border cell migration, with loss of dmim function resulting in a lack of directional movement by the border cell cluster. In vivo endocytosis assays combined with genetic analyses demonstrate that the dmim product regulates directed cell movement by inhibiting endocytosis and antagonizing the activities of the endophilin/CD2AP/cortactin complex in these cells. These studies demonstrate that competition between BAR family members for pro-endocytic components underlies a directional sensing mechanism during guided cell migration.
  • Print
    Carol Tavris and Elliot Aronson.
    Print2007
    Status: Not Checked OutLane Catalog Record
    Many of the examples involve physicians and medical situations, both clinical and research.
  • Digital
    volume editors, Kurt S. Zänker, Srini V. Kaveri.
    Digital : Karger2015
    Mistletoe through cultural and medical history : the all-healing plant proves to be a cancer-specific remedy / Ramm, H. -- Chemical constituents of viscum album L. : implications for the pharmaceutical preparation of mistletoe / Urech, K.; Baumgartner, S. -- The anti-cancer activity of mistletoe preparations, as related to their polyphenolic profiles / Schramm, H.M. -- From Berlin and Witten to Southampton and Hamburg : 25 years of mistletoe research cooperation / Schumacher, U.; Pfüller, U. -- Mistletoe compounds as anti-cancer drugs : effects and mechanisms in the treatment of glioblastoma / Schötterl, S.; Naumann, U. -- Cancer surgery and supportive mistletoe therapy : from scepticism to randomised clinical trials / Galun, D.; Tröger, W.; Milicevic, M. -- Dissecting the anti-inflammatory effects of viscum album : inhibition of cytokine-induced expression of cyclo-oxygenase-2 and secretion of prostaglandin E2 / Elluru, S.R.; Saha, C.; Hedge, P.; Friboulet, A.; Bayry, J.; Kaveri, S.V. -- Dancing with the Devil : cancer-related fatigue, from inflammation to treatment options / Zänker, K.S.
  • Digital
    edited by Liza A. Pon, Eric A. Schon.
    Digital : ScienceDirect2007
    Print2007
  • Digital
    edited by Stephen W. Schaffer and M.-Saadeh Suleiman.
    Digital : Springer2007
    Regulation of mitochondrial respiration in heart muscle / Ilmo Hassinen -- Regulation of fatty acid oxidation of the heart / Clifford D.L. Folmes and Gary D. Lopaschuk -- Regulation of mitochondrial fuel handling by the peroxisome proliferator-activated receptors / Mary C. Sugden and Mark J. Holness -- Molecular structure of the mitochondrial citrate transport protein / Ronald S. Kaplan and June A. Mayor -- Regulation of pyruvate and amino acid metabolism / Thomas C. Vary, Wiley W. Souba, and Cristopher J. Lynch -- Amino acids and the mitochondria / Nicola King -- Mechanotransduction of shear-stress at the mitochondria / Abu-Bakr Al-Mehdi -- Formation of reactive oxygen species in mitochondria / Julio F. Turrens -- Mitochondrial calcium : role in the normal and ischaemic/reperfused myocardium / Elinor J. Griffiths ... [et al.] -- Mitochondrial ion channels / Brian O'Rourke -- The mitochondrial permeability transition pore : from molecular mechanism to reperfusion injury and cadioprotection / Andrew P. Halestrap, Samantha J. Clarke, and Igor Khalilin -- The apoptotic mitochondrial pathway : modulators, interventions, and clinical implications / M.-Saadeh Suleiman and Stephen W. Schaffer -- The role of mitochondria in necrosis following myocardial ischemia-reperfusion / Elizabeth Murphy and Charles Steenbergen -- Mitochondria and their role in ischemia/reperfusion injury / Sebastian Phillip, James M. Downey, and Michael V. Cohen -- Mitochondrial DNA damage and repair / Inna N. Shokolenko, Susan P. Ledoux, and Glenn L. Wilson.
  • Digital
    edited by Dario Leister, Johannes Herrmann.
    Digital : Springer Protocols2007.
    Offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike.
  • Digital
    Keshav K. Singh, Leslie C. Costello, editors.
    Digital : Springer2009
  • Digital
    edited by José Marín-García ; with the collaboration of Michael J. Goldenthal.
    Digital : Springer2005
    Print2005
  • Digital
    by José Marín-García ; with contributions by Alexander Akhmedov and Vitalyi Rybin, Gordon W. Moe.
    Digital : Springer2013
    Part 1. General principles of mitochondria and the heart -- Introduction to Mitochondria in the Heart -- Methods to Study Mitochondrial Structure and Function -- Mitochondrial Structure, Composition, and Dynamics -- Mitochondrial Biogenesis -- Mechanisms of Bioenergy Production in Mitochondria -- Bioenergetics Interplay Between Cardiac Mitochondria and Other Subcellular Compartments -- Part 2. Heart mitochondria signal transduction. Stem cells -- Endothelial Mitochondria: Contribution to Cardiovascular Function and Disease -- Heart Mitochondria: Receivers and Transmitters of Signals -- Stem Cells and Mitochondria -- Part 3. Stress and cell death -- Heart Mitochondrial ROS and Oxidative Stress -- Cell-Death Pathways and Mitochondria -- Part 4. Mitochondria in Pediatric Cardiology -- Mitochondria in Pediatric Cardiovascular Diseases -- Part 5. The aging heart and mitochondria -- Mitochondria in the Aging Heart -- Part 6. Mitochondria in Atherosclerosis, hypertension and ischemia -- The Role of Mitochondria in Atherosclerosis -- The Role of Mitochondria in Hypertension -- Role of Mitochondria in Ischemia and Cardioprotection -- Part 7. Mitochondria in Heart Failure and Dysrhythmias -- Mitochondrial Dynamics in Health and Disease -- Mitochondria Play an Essential Role in Heart Failure -- Mitochondria and Cardiac Dysrhythmias -- Part 8. Mitochondria in heart metabolism -- Diabetes and Cardiac Mitochondria -- The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance -- Thyroid Hormone and Myocardial Mitochondria -- Part 9. Mitochondrial Therapy -- Targeting the Mitochondria in Cardiovascular Diseases -- Part 10. Looking to the future of mitochondria and the heart -- Current Progress and Future Perspectives: Toward Mitochondrial Medicine.
  • Digital
    Dhyan Chandra, editor.
    Digital : Springer2013
    This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer.
  • Digital
    Lena Pernas.
    Digital2013
    Protozoan and prokaryotic pathogens are able to recruit mitochondria to the vacuoles in which they grow (Friis, 1972; Horwitz, 1983), in mammalian and protozoan cells. The functional significance of the recruitment and association of this phenomenon in Toxoplasma-infected cells has been a subject of speculation since it was first described in the early 1970s (Jones et al., 1972). Previous work has proposed Toxoplasma gondii rhoptry protein 2 (Sinai and Joiner, 2001) as the physical link that tethers host mitochondria to the parasitophorous vacuole and conventional wisdom since has suggested that mitochondrial recruitment served a nutritional function supplementary to the parasite. A recent analysis of the ROP2 structure raised questions about this model ((Labesse et al., 2009; Reese and Boothroyd, 2009). Chapter II describes the effect of deleting ROP2 on mitochondrial association while Chapter III describes the identification of a novel mediator of mitochondrial association, Mitochondrial association factor I (MAF1) and experiments that attempt to answer the role of this remarkable phenomenon in the host-pathogen interaction. Chapter IV describes a project undertaken to determine the impact of Toxoplasma gondii infection in humans acutely and chronically infected in different geographical regions. Chapter V concludes with a discussion of future directions for further characterization of host mitochondrial association in the host response to microbial infection.
  • Digital
    edited by Carlos M. Palmeira, António J. Moreno.
    Digital : Springer Protocols2012
    Overview of mitochondrial bioenergetics / Vitor M.C. Madeira -- Evaluation of respiration with Clark type electrode in isolated mitochondria and permeabilized animal cells / Ana M. Silva and Paulo J. Oliveira -- High-resolution respirometry : OXPHOS protocols for human cells and permeabilized fibers from small biopsies of human muscle / Dominik Pesta and Erich Gnaiger -- High-throughput analysis of mitochondrial oxygen consumption / James Hynes, Rachel L. Swiss, and Yvonne Will -- Modulation of cellular respiration by endogenously produced nitric oxide in rat hippocampal slices / Ana Ledo, R.M. Barbosa, and J. Laranjinha -- Mitochondrial membrane potential ([delta][psi]) fluctuations associated with the metabolic states of mitochondria / Carlos M. Palmeira and Anabela P. Rolo -- Safranine as a fluorescent probe for the evaluation of mitochondrial membrane potential in isolated organelles and permeabilized cells / Tiago R. Figueira ... [et al.] -- Fluorescence measurement of mitochondrial membrane potential changes in cultured cells / David G. Nicholls -- Phenomenological kinetic and control analysis of oxidative phosphorylation in isolated mitochondria / Vilmante Borutaite and Rasa Baniene -- Expression of uncoupling proteins in a mammalian cell culture system (HEK293) and assessment of their protein function / Martin Jastroch -- Measurement of proton leak and electron leak in isolated mitochondria / Charles Affourtit, Casey L. Quinlan, and Martin D. Brand -- Relation between mitochondrial membrane potential and ROS formation / Jan M. Suski ... [et al.] -- Use of a calcium-sensitive electrode for studies on mitochondrial calcium transport / António J.M. Moreno and Joaquim A. Vicente -- Imaging mitochondrial calcium signalling with fluorescent probes and single or two photon confocal microscopy / Sean M. Davidson and Michael R. Duchen -- Mitochondrial permeability transition pore and calcium handling / Renee Wong, Charles Steenbergen, and Elizabeth Murphy -- Imaging of mitochondrial pH using SNARF-1 / Venkat K. Ramshesh and John J. Lemasters -- Redox equivalents and mitochondrial bioenergetics / James R. Roede, Young-Mi Go, and Dean P. Jones -- NMR methodologies for studying mitochondrial bioenergetics / Tiago C. Alves, Ivana Jarak, and Rui A. Carvalho -- Computational modeling of mitochondrial function / Sonia Cortassa and Miguel A. Aon.
  • Digital
    edited by Giuse M. Attardi, Anne Chomyn.
    Digital : ScienceDirect1995
    Print1995
  • Digital
    edited by Giuseppe M. Attardi, Anne Chomyn.
    Digital : ScienceDirect1996
    Print1996
  • Digital
    edited by Lee-Jun C. Wong.
    Digital : Springer Protocols2012
    Mitochondrial DNA mutations : an overview of clinical and molecular aspects / William J. Craigen -- Nuclear gene defects in mitochondrial disorders / Fernando Scaglia -- Diagnostic challenges of mitochondrial disorders : complexities of two genomes / Brett H. Graham -- Biochemical analyses of the electron transport chain complexes by spectrophotometry / Ann E. Frazier and David R. Thorburn -- Measurement of mitochondrial oxygen consumption using a Clark electrode / Zhihong Li and Brett H. Graham -- Mitochondrial respiratory chain : biochemical analysis and criterion for deficiency in diagnosis / Manuela M. Grazina -- Assays of pyruvate dehydrogenase complex and pyruvate carboxylase activity / Douglas Kerr, George Grahame, and Ghunwa Nakouzi -- Assessment of thymidine phosphorylase function : measurement of plasma thymidine (and deoxyuridine) and thymidine phosphorylase activity / Ramon Martí, Luis C. López, and Michio Hirano -- Measurement of mitochondrial dNTP pools / Ramon Martí, Beatriz Dorado, and Michio Hirano -- Measurement of oxidized and reduced coenzyme Q in biological fluids, cells, and tissues : an HPLC-EC method / Peter H. Tang and Michael V. Miles -- Assay to measure oxidized and reduced forms of CoQ by LC-MS/MS / Si Houn Hahn, Sandra Kerfoot, and Valeria Vasta -- Morphological assessment of mitochondrial respiratory chain function on tissue sections / Kurenai Tanji -- Blue native polyacrylamide gel electrophoresis : a powerful diagnostic tool for the detection of assembly defects in the enzyme complexes of oxidative phosphorylation / Scot C. Leary -- Radioactive labeling of mitochondrial translation products in cultured cells / Florin Sasarman and Eric A. Shoubridge -- Transmitochondrial cybrids : tools for functional studies of mutant mitochondria / Sajna Antony Vithayathil, Yewei Ma, and Benny Abraham Kaipparettu -- Fluorescence-activated cell sorting analysis of mitochondrial content, membrane potential, and matrix oxidant burden in human lymphoblastoid cell lines / Stephen Dingley, Kimberly A. Chapman, and Marni J. Falk -- Molecular profiling of mitochondrial dysfunction in Caenorhabditis elegans / Erzsebet Polyak, Zhe Zhang, and Marni J. Falk -- Analysis of common mitochondrial DNA mutations by allele-specific oligonucleotide and southern blot hybridization / Sha Tang [and others] -- Sequence analysis of the whole mitochondrial genome and nuclear genes causing mitochondrial disorders / Megan L. Landsverk, Megan E. Cornwell, and Meagan E. Palculict -- Utility of array CGH in molecular diagnosis of mitochondrial disorders / Jing Wang and Mrudula Rakhade -- Quantification of mtDNA mutation heteroplasmy (ARMS qPCR) / Victor Venegas and Michelle C. Halberg -- Measurement of mitochondrial DNA copy number / Victor Venegas and Michelle C. Halberg -- Determination of the clinical significance of an unclassified variant / Victor Wei Zhang and Jing Wang.
  • Digital
    Lee-Jun C. Wong, editor.
    Digital : Springer2013
    Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorders usually affects multiple organs. Mitochondrial Disorders Caused by Nuclear Genes discusses the biochemical, molecular, clinical, and genetic aspects of complex dual genome mitochondrial disorders. Chapters include genes involved in mitochondrial DNA biogenesis and maintenance of mitochondrial DNA integrity, complex subunits and assembly genes, and mitochondrial protein translation related diseases.
  • Digital
    edited by Matthew McKenzie
    Digital : Springer Protocols2016
    Part I. Detection of mitochondrial DNA mutations and mitochondrial DNA damage -- Part II. Visualization of mitochondrial DNA and mitochondrial DNA nucleoids -- Part III. Analysis of mitochondrial DNA replication, mitochondrial DNA-encoded protein translation and mitochondrial DNA copy number -- Part IV. Modification of mitochondrial DNA -- Part V. Purification of proteins involved in mitochondrial DNA replication and transcription -- Index.
  • Digital
    edited by Jeffrey A. Stuart.
    Digital : Springer Protocols2009
    Biochemical isolation of mtDNA nucleoids from animal cells / D.F. Bogenhagen -- Analysis of mitochondrial DNA by two-dimensional agarose gel electrophoresis / A. Reyes [and others] -- Comparative purification strategies for Drosophila and human mitochondrial DNA replication proteins: DNA polymerase gamma and mitochondrial single-stranded DNA-binding protein / M.T. Oliveira and L.S. Kaguni -- Functional analysis of mutant mitochondrial DNA polymerase proteins involved in human disease / S.S. Chan and W.C. Copeland -- Preparation of human mitochondrial single-stranded DNA-binding protein / M.J. Longley, L.A. Smith and W.C. Copeland -- Methods for assessing binding of mitochondrial transcription factor A (TFAM) to DNA / A. Fukuoh and D. Kang -- Inducible expression in human cells, purification, and in vitro assays for the mitochondrial DNA helicase Twinkle / S. Goffart and H. Spelbrink -- Purification strategy for recombinant forms of the human mitochondrial DNA helicase / T.D. Ziebarth and L.S. Kaguni -- Methods for studying mitochondrial transcription termination with isolated components / P.L. Polosa [and others] -- Oxidative phosphorylation: synthesis of mitochondrially encoded proteins and assembly of individual structural subunits into functional holoenzyme complexes / S.C. Leary and F. Sasarman -- Reactive oxygen species production by mitochondria / A.J. Lambert and M.D. Brand -- Measuring mtDNA damage using a supercoiling-sensitive qPCR approach / S.W. Chan and J.Z. Chen -- Quantitative analysis of oxidized guanine, 8-oxoguanine, in mitochondrial DNA by immunofluorescence method / M. Ohno, S. Oka and Y. Nakabeppu -- In vitro measurement of DNA base excision repair in isolated mitochondria / M.M. Page and J.A. Stuart -- Targeting repair proteins to the mitochondria of mammalian cells through stable transfection, transient transfection, viral transduction, and TAT-mediated protein transduction / C.A. Koczor [and others] -- Construction and characterization of a cell line deficient in repair of mitochondrial, but not nuclear, oxidative DNA damage / S. Oka, M. Ohno and Y. Nakabeppu -- Mitochondrial DNA oxidative damage and mutagenesis in Saccharomyces cerevisiae / L.M. Griffiths [and others] -- Determination of DNA mutation load in human tissues using denaturing HPLC-based heteroduplex analysis / K.S. Lim, R.K. Naviaux and R.H. Haas -- Rapid identification of unknown heteroplasmic mitochondrial DNA mutations with mismatch-specific surveyor nuclease / S. Bannwarth, V. Procaccio and V. Paquis-Flucklinger -- Collection of isolated cells for studying mitochondrial DNA mutations within individual cells / Y. Kraytsberg [and others] -- Quantitative analysis of somatic mitochondrial DNA mutations by single-cell single-molecule PCR / Y. Kraytsberg [and others] -- Measuring DNA precursor pools in mitochondria / C.K. Mathews and L.J. Wheeler -- Establishment of human cell lines lacking mitochondrial DNA / K. Hashiguchi and Q.M. Zhang-Akiyama.
  • Digital
    Justin C. St. John, editor.
    Digital : Springer2013
    1. Clinical Approach to the Diagnosis of Mitochondrial Disease / Dominic Thyagarajan, p. 1-23 -- 2. Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease / Matthew McKenzie, p. 25-47 -- 3. Embryonic Stem Cells: A Signalling Perspective / Marios P. Stavridis, p. 49-68 -- 4. From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey / João Ramalho-Santos, Ana Sofia Rodrigues, p. 69-86 -- 5. From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases / João Facucho-Oliveira, Tejal Kulkarni, p. 87-118 -- 6. The Role of Mitochondrial DNA in Tumorigenesis / Ka Yu Yeung, Adam Dickinson, p. 119-155 -- 7. Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next / Richard D. W. Kelly, Arsalan Mahmud, p. 157-183.
  • Digital
    Bingwei Lu, editor.
    Digital : Springer2011
    The Genetics of Mitochondrial Fusion and Fission -- Relationships Between Mitochondrial Dynamics and Bioenergetics -- no access69-108 Mitochondrial Dynamics and Autophagy -- Mitochondrial Dynamics and Apoptosis -- Mitochondrial Dynamics and Axonal Transport -- Neurological Diseases Associated with Mutations in the Mitochondrial Fusion Machinery -- Mitochondrial Fission-Fusion and Parkinson's Disease: A Dynamic Question of Compensatory Networks -- Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration -- Mitochondrial Dynamics and Huntington's Disease: A Dance of Fate -- Back matter.
  • Digital
    Gaetano Santulli, editor ; foreword by Wilson S. Colucci.
    Digital : Springer2017
    "This text covers the basic principles of mitochondrial dynamics in cardiovascular medicine, with particular emphasis on their functional roles in physiology and disease. The book will include articles pertaining to mitochondrial fitness on a global basis, providing therefore an update on the progress made in several aspects in the field. Thus, it will assist scientists and clinicians alike in furthering basic and translational research. Organized in sections focusing on: basic science, mitochondrial dysfunction in cardiac disorders, in vascular disorders, in metabolic disorders, in kidney disease, therapeutic challenges and options, this essential volume fills imperative gaps in understanding and potentially treating several cardiovascular disorders"--Publisher's description.
  • Digital
    Amy Katherine Reeve, Kim Jennifer Krishnan, Michael R. Duchen, Doug M. Turnbull, editors.
    Digital : Springer2012
    Pt. 1. Mitochondrial function and genetics -- pt. 2. Mitochondrial dysfunction : causes and effects? -- pt. 3. Functional consequences of mitochondrial dysfunction -- pt. 4. Modeling mitochondrial contribution to neurodegerative diseases -- pt. 5. The future.
  • Digital
    Amy K. Reeve, Eve M. Simcox, Michael R. Duchen, Doug M. Turnbull, editors.
    Digital : Springer2016
    Part I. Mitochondria and Neurodegenerative Disease -- An Introduction to Mitochondria, Their Structure and Functions -- Part II. Mitochondrial Dysfunction: Causes and Effects? -- Neurodegeneration in Mitochondrial Disorders -- The Ageing Brain, Mitochondria and Neurodegeneration -- Mitochondrial Genes and Neurodegenerative Disease -- Mitochondrial Signalling and Neurodegeneration -- Part III. Functional Consequences of Mitochondrial Dysfunction -- Life on the Edge: Determinants of Selective Neuronal Vulnerability in Parkinson's Disease -- Mitochondrial Dynamics and Neurodegeneration -- Mitochondrial Dysfunction and Transport in Demyelinating Disease with Inflammation -- Mitochondria, the Synapse, and Neurodegeneration -- Protein Misfolding and Aggregation: Implications for Mitochondrial Dysfunction and Neurodegeneration -- Mitochondrial Degradation, Autophagy and Neurodegenerative Disease -- The Deleterious Duo of Neurodegeneration: Lysosomes and Mitochondria -- Part IV. Measuring the Contribution of Mitochondrial Dysfunction to Neurodegenerative Disease -- Can We Accurately Model Mitochondrial Dysfunction in Neurodegeneration? -- Mitochondrial Function and Dynamics Imaged In Vivo -- Part V. The Future -- Development of Treatments and Therapies to Target Mitochondrial Dysfunction -- Summary and Conclusions.
  • Print
    Joshua David Mast.
    Print2007
    Status: Not Checked OutLane Catalog Record
  • Digital
    volume editor, Anne N. Murphy, David C. Chan.
    Digital : ScienceDirect2014
  • Digital
    edited by William S. Allison and Immo E. Scheffler.
    Digital : ScienceDirect2009
    Print2009
  • Digital
    edited by William S. Allison, Anne N. Murphy.
    Digital : ScienceDirect2009
    Print2009
  • Digital
    Viswanathan Natarajan, Narasimham L. Parinandi, editors.
    Digital : Springer2014
    Mitochondria, often referred to as the 'powerhouses' of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
  • Digital
    Gabriel D. Dakubo.
    Digital : Springer2010
    1. Basic mitochondrial genetics, bioenergetics, and biogenesis -- 2. The Warburg phenomenon and other metabolic alterations of cancer cells -- 3. Mitochondrial control of apoptosis and cancer -- 4. Mitochondrial-to-nuclear communications in cancer -- 5. Types of mitochondrial genetic alterations in cancer -- 6. Mitochondrial genetic alterations in cancer I: skin, head and neck, salivary glands, thyroid, breast, lung, esophageal, gastric, colorectal, pancreatic, liver and gallbladder cancers -- 7. Mitochondrial genetic alterations in cancer II: renal, urinary bladder, prostate, ovarian, endometrial, cervical, nervous system, hemoatologic and connective tissue cancers -- 8. Mitochondrial genome rearrangement and copy number changes in cancer -- 9. Functional importance of mitochondrial genetic alterations in cancer -- 10. The role of mitochondrial reactive oxygen species in cancer -- 11. Mitochondrial DNA measurement in exfoliated cells for cancer detection and monitoring: the copy number advantage -- 12. Early cancer detection and monitoring using changes in the mitochondrial genome as biosensors -- 13. Analysis of mitochondrial genome alterations in cancer -- 14. "Mitocans": agents targeting mitochondria to kill cancer cells -- Index.
  • Digital
    Anna Gvozdjáková, editor.
    Digital : Springer2008
  • Digital
    edited by Volkmar Weissig, Marvin Edeas.
    Digital : Springer Protocols2015
    This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. "Mitochondrial Medicine: Volume I, Probing Mitochondrial Function" focuses on methods being used for the assessment of mitochondrial function under physiological conditions as well as in healthy isolated mitochondria. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, "Mitochondrial Medicine" provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
  • Digital
    edited by Volkmar Weissig, Marvin Edeas.
    Digital : Springer Protocols2015
    This expert volume covers an interdisciplinary and rapidly growing area of biomedical research comprising genetic, biochemical, pathological, and clinical studies aimed at the diagnosis and therapy of human diseases which are either caused by or associated with mitochondrial dysfunction. It dedicates itself to showcasing the tremendous efforts and the progress that has been made over the last decades in developing techniques and protocols for probing, imaging, and manipulating mitochondrial functions. "Mitochondrial Medicine: Volume II, Manipulating Mitochondrial Function" describes techniques developed for manipulating and assessing mitochondrial function under general pathological conditions and specific disease states. Written in the highly successful "Methods in Molecular Biology" series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls.Comprehensive and practical, "Mitochondrial Medicine" provides an essential source of know-how and inspiration to all researchers who are fascinated by this tiny organelle that seems so clearly to control the life and death of a single cell and whole organisms alike.
  • Digital
    Bernhard Kadenbach, editor.
    Digital : Springer2012
    Introduction to Mitochondrial Oxidative Phosphorylation / Bernhard Kadenbach -- Mitochondrial Dynamics: The Intersection of Form and Function / Andrew Ferree and Orian Shirihai -- Biogenesis of Mitochondrial Proteins / Johannes M. Herrmann, Sebastian Longen, Daniel Weckbecker and Matthieu Depuydt -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology / Daniele Ghezzi and Massimo Zeviani -- Supramolecular Organisation of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation / Giorgio Lenaz and Maria Luisa Genova -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain / Stefan Dröse and Ulrich Brandt -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins / Richard K. Porter -- Evolution of the Couple Cytochrome c and Cytochrome c Oxidase in Primates / Denis Pierron, Derek E. Wildman, Maik Hüttemann, Thierry Letellier and Lawrence I. Grossman -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome c Oxidase / Shinya Yoshikawa, Kazumasa Muramoto and Kyoko Shinzawa-Itoh -- Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease / Maik Hüttemann, Icksoo Lee, Lawrence I. Grossman, Jeffrey W. Doan and Thomas H. Sanderson -- Individual Biochemical Behaviour Versus Biological Robustness: Spotlight on the Regulation of Cytochrome c Oxidase / Rabia Ramzan, Petra Weber, Bernhard Kadenbach and Sebastian Vogt -- Bigenomic Regulation of Cytochrome c Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism / Margaret T. T. Wong-Riley -- Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection / Susanne Arnold -- The Many Clinical Faces of Cytochrome c Oxidase Deficiency / Salvatore DiMauro, Kurenai Tanji and Eric A. Schon.
  • Digital
    edited by Carlos M. Palmeira, Anabela P. Rolo.
    Digital : Springer Protocols2015
    Isolation of crude mitochondrial fraction from cells / Mariusz R. Wieckowski and Lech Wojtczak -- Isolation of mitochondria from liver and extraction of total RNA and protein : analyses of MicroRNA and protein expressions / Pedro M. Borralho, Clifford J. Steer, and Cecília M.P. Rodrigues -- PCR based determination of mitochondrial DNA copy number in multiple species / John P. Rooney [and eight others] -- NAD+ content and its role in mitochondria / Wei Li and Anthony A. Sauve -- Measuring PGC-1[alpha] and its acetylation status in mouse primary myotubes / Ana P. Gomes and David A. Sinclair -- Measurement of mitochondrial oxygen consumption rates in mouse primary neurons and astrocytes / Sofia M. Ribeiro, Alfredo Giménez-Cassina, and Nika N. Danial -- Determination of oxidative phosphorylation complexes activities / João S. Teodoro, Carlos M. Palmeira, and Anabela P. Rolo -- Histoenzymatic methods for visualization of the activity of individual mitochondrial respiratory chain complexes in the muscle biopsies from patients with mitochondrial defects / Agnieszka Karkucinska-Wieckowska, Maciej Pronicki, and Mariusz R. Wieckowski -- A method aimed at assessing the functional consequences of the supramolecular organization of the respiratory electron transfer chain by time- resolved studies / Fabrice Rappaport -- BN-PAGE-based approach to study thyroid hormones and mitochondrial function / Elena Silvestri [and three others] -- Detection of UCP1 protein and measurements of dependent GDP-sensitive proton leak in non- phosphorylating thymus mitochondria / Kieran J. Clarke [and three others] -- Exploring liver mitochondrial function by 13C-stable isotope breath tests : implications in clinical biochemistry / Ignazio Grattagliano [and five others] -- Following mitochondria dynamism : confocal analysis of the organelle morphology / Francesca R. Mariotti, Mauro Corrado, and Silvia Campello -- Analysis of pro-apoptotic protein trafficking to and from mitochondria / Ignacio Vega-Naredo [and four others] -- Mitophagy and mitochondrial balance / Simone Patergnani and Paolo Pinton.
  • Digital
    edited by Sten Orrenius, Lester Packer, Enrique Cadenas.
    Digital : CRCnetBASE2012
    "This book examines a unique assembly of coordinated mitochondrial functions that are important in regulating cell function and are of relevance in a myriad of pathophysiological situations, such as age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. The text covers themes essential for the maintenance of mitochondrial activity, including electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book features chapters that are reviews of the important topics covered and are written by an impressive cadre of internationally recognized scientist"--Provided by publisher.
  • Digital
    edited by David Sharp.
    Digital : Springer Protocols2014
    Analysis of Mitotic Protein Dynamics and Function in Drosophila Embryos by Live Cell Imaging and Quantitative Modeling -- Rapid Measurement of Mitotic Spindle Orientation in Cultured Mammalian Cells -- Automated Segmentation of the First Mitotic Spindle in Differential Interference Contrast Micro copy Images of C. elegans Embryos -- Imaging the Mitotic Spindle by Spinning Disk Microscopy in Tobacco Suspension Cultured Cells -- Image-Based Computational Tracking and Analysis of Spindle Protein Dynamics -- The Use of Cultured Drosophila Cells for Studying the Microtubule Cytoskeleton -- Measuring Microtubule Growth and Gliding in C. elegans Embryos -- XenopusEgg Extracts as a Simplified Model System for Structure Function Studies of Dynein Regulators -- Covalent Immobilization of Microtubules on Glass Surfaces for Molecular Motor Force Measurements and Other Single-Molecule Assays -- An Improved Optical Tweezers Assay for Measuring the Force Generation of Single Kinesin Molecules -- Seeded Microtubule Growth for Cryo-electron Microscopy of End Binding Proteins -- The Segmentation of Microtubules in Electron Tomograms using Amira -- Manipulating Cell Shape by Placing Cells into Micro-fabricated Chambers -- Four color FISH for the Detection of Low Levels Aneuploidy in Interphase Cells.
  • Digital
    R. Hetzer, J.S. Rankin, C.A. Yankah, (eds.).
    Digital : Springer2011
    Part I. Imaging of the mitral valve -- Part II. Congenital mitral and tricuspid disease -- Part III. Degenerative mitral valve disease -- Part IV. Ischemic mitral regurgitation -- Part V. Inflammatory mitral valve disease -- Part VI. Atlas of mitral and tricuspid annuloplasty rings -- Part VII. Acknowledgements -- Part VIII. Subject Index.
  • Digital
    Robert S. Bonser, Domenico Pagano, Axel Haverich (Editors).
    Digital : Springer2011
    Surgical anatomy of the mitral and tricuspid valve -- Pathology and classification of mitral valve disease -- Chronic mitral regurgitation -- Chronic ischemic mitral regurgitation -- Asymptomatic mitral valve regurgitation: watchful wait or early repair?: review of the current evidence -- Mitral valve prosthesis insertion with preservation of the sub-valvar apparatus -- How I assess and repair the Barlow mitral valve: the respect rather than resect approach -- How I assess and repair the Barlow mitral valve: the edge-to-edge technique -- How I assess and repair the Barlow mitral valve -- Ischemic mitral regurgitation -- Minimally invasive mitral valve surgery -- Mitral stenosis -- Atrial fibrillation: non-surgical management -- Ablation of atrial fibrillation with cardiac surgery -- Tricuspid regurgitation: natural history, assessment, and intervention.
  • Print
    American College of Physicians ; editor-in-chief: Patrick C. Alguire.
    Status: Not Checked OutLane Catalog Record
    [v.1] Cardiovascular medicine -- [v. 2] Gastroenterology and hepatology -- [v. 3] Hematology and oncology -- [v. 4] Neurology -- [v. 5] Rheumatology -- [v. 6] Dermatology -- [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative Index.
  • Print
    American College of Physicians ; editor-in-chief, Patrick C. Alguire.
    Status: Not Checked OutLane Catalog Record
    Part A -- [v. 1] Cardiovascular medicine -- [v. 2] Dermatology -- [v. 3] Gastroenterology and hepatology -- [v. 4] Hematology and oncology -- [v. 5] Neurology -- [v. 6] Rheumatology -- [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative index.
  • Print
    American College of Physicians.
    Status: Not Checked OutLane Catalog Record
    Part A: [v. 1] Cardiovascular medicine -- [v. 2] Dermatology -- [v. 3] Gastroenterology and hepatology -- [v. 4] Hematology and oncology -- [v. 5] Neurology -- [v. 6] Rheumatology -- Part B: [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative index.
  • Digital
    edited by Yves Bigot.
    Digital : Springer Protocols2012
    Transposable elements as tools for reshaping the genome : it is a huge world after all! / Solenne Bire and Florence Rouleaux-Bonnin -- Using and understanding RepeatMasker / Sébastien Tempel -- Roadmap for annotating transposable elements in eukaryote genomes / Emmanuelle Permal, Timothée Flutre, and Hadi Quesneville -- To detect and analyze sequence repeats whatever be their origin / Jacques Nicolas -- Exploring bacterial insertion sequences with ISfinder : objectives, uses, and future developments / P. Siguier [and others] -- Methods and software in NGS for TE analysis / Cristian Chaparro and Francois Sabot -- The application of LTR retrotransposons as molecular markers in plants / Alan H. Schulman [and others] -- Individual analysis of transposon polymorphisms by AFLP / Susanta K. Behura -- Construction of a library of random mutants in the spirochete Leptospira biflexa using a mariner transposon / Leyla Slamti and Mathieu Picardeau -- Ac-Ds solutions for rice insertion mutagenesis / Emmanuel Guiderdoni and Pascal Gantet -- Engineering the Caenorhabditis elegans genome by Mos1-induced transgene-instructed gene conversion / Valérie J.P. Robert -- Genome-wide manipulations of Drosophila melanogaster with transposons, Flp recombinase, and [phi]C31 integrase / Koen J.T. Venken and Hugo J. Bellen -- The Sleeping Beauty transposon toolbox / Ismahen Ammar, Zsuzsanna Izsvák, and Zoltán Ivics -- PiggyBac toolbox / Mario Di Matteo [and others] -- Insertion site pattern : global approach by linear amplification-mediated PCR and mass sequencing / Cynthia C. Bartholomae [and others] -- Comprehensive DNA methylation profiling of human repetitive DNA elements using an MeDIP-on-RepArray assay / Eric Gilson and Béatrice Hovard -- Novel approach for the development of new antibodies directed against transposase-derived proteins encoded by human neogenes / Ahmed Arnaoty [and others].
  • Digital
    edited by Avraham Rasooly, Keith E. Herold.
    Digital : Springer Protocols2015
    Mobile device for disease diagnosis and data tracking in resource-limited settings -- Microfluidic devices for nucleic acid (NA) isolation, isothermal NA amplification, and real-time detection -- Mobile based gold nanoprobe TB diagnostics for point-of-need -- Immunofluorescence microtip sensor for point-of-care tuberculosis (TB) diagnosis -- Improving lateral-flow immunoassay (LFIA) diagnostics via biomarker enrichment for mHealth -- Microfluidic toner-based analytical devices: Disposable, lightweight, and portable platforms for point-of-care diagnostics with colorimetric detection -- Detection of protein biomarker using a blood glucose meter -- Microchip ELISA coupled with cell phone to detect ovarian cancer HE4 biomarker in urine -- Point-of-care rare cell cancer diagnostics -- Mobile flow cytometer for mHealth -- Mobile fiber-optic sensor for detection of oral and cervical cancer in the developing world -- Opto-fluidics based microscopy and flow cytometry on a cell phone for blood analysis -- Optofluidic device for label-free cell classification from whole blood -- A wearable sensing system for assessment of exposures to environmental volatile organic compounds -- Quantitative point-of-care (POC) assays using measurements of time as the readout: A new type of readout for mHealth -- Smartphone-based fluorescence detector for mHealth -- Two-layer lab-on-a-chip (LOC) with passive capillary valves for mHealth medical diagnostics -- Spectrometry with consumer-quality CMOS cameras -- Mobile phone based electrochemiluminescence detection in paper-based microfluidic sensors -- iStethoscope: A demonstration of the use of mobile devices for auscultation -- iPhysiometer: A smartphone photoplethysmograph for measuring various physiological indices -- Smartphone attachment for stethoscope recording -- Use of smartphones and portable media devices for quantifying human movement characteristics of gait, tendon reflex response, and Parkinson's disease hand tremor -- Measuring tremor with a smartphone -- The use of single-electrode wireless EEG in biobehavioral investigations -- Smartphone based monitoring system for long-term sleep assessment -- Intracranial ventricular catheter placement with a smartphone assisted instrument -- High-resolution microendoscope for the detection of cervical neoplasia -- Skin lesions image analysis utilizing smartphones and cloud platforms -- Melanoma and other skin lesion detection using smart handheld devices.
  • Digital
    Frits Tjadens, Caren Weilandt, Josef Eckert.
    Digital : Springer2013
    Introduction -- International mobility as a process -- Factors contributing to mobility of health workers -- Countries, structures and systems -- Some notions about the European dimension -- Managing mobile health workforces? -- Conclusions, challenges and recommendations.
  • Print
    Wade Charles Anderson.
    Print2008
    Status: Not Checked OutLane Catalog Record
  • Digital
    David R. Anderson.
    Digital : Springer2008
  • Digital
    Susan S. Aronson, MD, FAAP, editor.
    Digital : ProQuest Ebook Central2014
  • Print
    edited by Hugo Tempelman, Mariette Slabbert, Anke Gosling, Adri Vermeer ; in cooperation with Geert Blijham ... [et al.].
    Print2010
    Status: Not Checked OutLane Catalog Record
    "The Ndlovu Care Group (NCG), a South African NGO, provides health care and community care for people living in a rural area of South Africa, in particular the Moutse area in Limpopo and Mpumalanga provinces. There are 120,000 to 150,000 beneficiaries. In a period of 15 years, Hugo Tempelman and co-workers developed an integrated model of care serving the broad health and community needs of poor people in an area where almost no medical and health care services are provided. This book describes a model for the advancement of rural areas in South Africa through community health and community care as developed by NCG. Over the years it became evident that this model could have an impact on the further advancement of rural areas in any developing country. NCG operates through two divisions, the Autonomous Treatment Centre (ATC) and the Community Health Awareness Mobilisation & Prevention (CHAMP) programme. The ATC is an extended community health centre that provides integrated primary health, TB and HIV/AIDS care and treatment, including maternal and reproductive health care and advanced HIV/AIDS in-patient care. The co-operation with governmental departments is described. The CHAMP programme consists of an AIDS awareness programme for schools, farms and local communities; programmes for vulnerable children because of e.g. HIV & AIDS infection, under- and malnourishment, disturbed family life, death of parents; a dental programme; art, culture and sports activities; all kinds of community activities, like a waste programme, a nappy factory and an IT training programme; and an environmental awareness and education programme. NCG has established its care model in two rural locations in South Africa, and is in the process of developing two more sites. To show the validity of its work, it also carries out monitoring & evaluation procedures and evidence-based research. Several chapters of this book testify to this scientific approach."--Back cover.
  • Digital
    Denise Guliato, Rangaraj M. Rangayyan.
    Digital : Atypon2011
    Malignant tumors due to breast cancer and masses due to benign disease appear in mammograms with different shape characteristics: the former usually have rough, spiculated, or microlobulated contours, whereas the latter commonly have smooth, round, oval, or macrolobulated contours. Features that characterize shape roughness and complexity can assist in distinguishing between malignant tumors and benign masses. In spite of the established importance of shape factors in the analysis of breast tumors and masses, difficulties exist in obtaining accurate and artifact-free boundaries of the related regions from mammograms. Whereas manually drawn contours could contain artifacts related to hand tremor and are subject to intra-observer and inter-observer variations, automatically detected contours could contain noise and inaccuracies due to limitations or errors in the procedures for the detection and segmentation of the related regions. Modeling procedures are desired to eliminate the artifacts in a given contour, while preserving the important and significant details present in the contour.
  • Digital
    Robert B. Denman, editor.
    Digital : Springer2012
    Print2012
    Introduction: Reminiscing on Models and Modeling / Robert B. Denman -- Probing Astrocyte Function in Fragile X Syndrome / Shelley Jacobs, Connie Cheng and Laurie C. Doering -- Neural Stem Cells / Maija Castrén -- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System / Theodore J. Price and Ohannes K. Melemedjian -- The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome / Stefan Kindler and Hans-Jürgen Kreienkamp -- Behavior in a Drosophila Model of Fragile X / Sean M. McBride, Aaron J. Bell and Thomas A. Jongens -- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome / Charles R. Tessier and Kendal Broadie -- Fragile X Mental Retardation Protein and Stem Cells / Abrar Qurashi, Xuekun Li and Peng Jin -- Manipulating the Fragile X Mental Retardation Proteins in the Frog / Marc-Etienne Huot, Nicolas Bisson, Thomas Moss and Edouard W. Khandjian -- Exploring the Zebra Finch Taeniopygia guttata as a Novel Animal Model for the Speech-Language Deficit of Fragile X Syndrome / Claudia Winograd and Stephanie Ceman -- Neuroendocrine Alterations in the Fragile X Mouse / Abdeslem El Idrissi, Xin Yan, William L'Amoreaux, W. Ted Brown and Carl Dobkin -- Taking STEPs Forward to Understand Fragile X Syndrome / Susan M. Goebel-Goody and Paul J. Lombroso -- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease / Bojana Zupan and Miklos Toth -- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome / Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen and Renate K. Hukema -- Clinical Aspects of the Fragile X Syndrome / W. Ted Brown -- Fragile X Syndrome: A Psychiatric Perspective / Michael R. Tranfaglia -- Fragile X Syndrome and Targeted Treatment Trials / Randi Hagerman, Julie Lauterborn, Jacky Au and Elizabeth Berry-Kravis -- The Fragile X-Associated Tremor Ataxia Syndrome / Flora Tassone and Randi Hagerman -- Vignettes: Models in Absentia / Robert B. Denman.
  • Print
    Jason Anthony Reuter.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by G.N. Reeke ... [et al.].
    Digital : CRCnetBASE2005
    Print2005
  • Print
    Matt J. Keeling and Pejman Rohani.
    Print2008
    Status: Not Checked OutLane Catalog Record
    Introduction to simple epidemic models -- Host heterogeneities -- Multi-pathogen / multi-host models -- Temporally forced models -- Stochastic dynamics -- Spatial models -- Controlling infectious diseases.
  • Digital
    Branden John Cord.
    Digital2012
    Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by tremor, rigidity, bradykinesia, and akinesia which affects approximately 1% of the population over the age of 60. These motor symptoms result from the selective destruction of midbrain dopamine (DA) neurons which form the nigrostriatal pathway. While there is likely to be a diverse range of inciting factors across patients, common pathological pathways mediating the selective loss of substantia nigral dopaminergic neurons are predicted. Only a small fraction of all PD cases can be ascribed to monogenic causes, however, these mutations provide our best chance for making progress in understanding PD pathophysiology. The accumulation and aggregation of alpha-synuclein (SNCA) in the form of Lewy bodies and Lewy neurites are defining neurocytological hallmarks for PD, suggesting that SNCA may be a linchpin to PD pathology. Duplications and triplications of SNCA are autosomal dominant causes of PD, and overexpression of SNCA has also recapitulated certain disease characteristics in animal and cell models. Mutations in the leucine rich repeat kinase 2 (LRRK2) are also implicated in PD pathogenesis. LRRK2 is predicted to interact either directly or indirectly with SNCA. Indeed, LRRK2 mutations are predicted to cause increased SNCA expression. As PD is only known to naturally occur in humans, and selectively targets midbrain DA neurons, a human midbrain DA neuron model involving known monogentic mutations would be a powerful platform for examining disease pathology. Here we describe the generation of induced pluripotent stem cells (iPSCs) created from patients with PD stemming from either an SNCA triplication (Trpl) or a G2019S mutation in LRRK2 (Lrkm). Human dopamine neuron cultures from these genetically-defined PD patients demonstrated overt pathological phenotypes. Both Trpl and Lrkm DA neuronal cultures contained an accumulation of monomeric SNCA, and markers of oxidative stress as compared to control embryonic stem cell (ESC) or iPSC lines. Trpl DA neuronal cultures possessed a marked increase in cells laden with ubiquitin puncta as compared to sibling control lines. Lrkm DA neuronal cultures were more susceptible to both the general oxidative stressor H2O2 and the selective DA neurotoxin 6-OHDA. These and other similarly derived lines will provide a powerful platform for investigating the molecular events in PD, and will enable large-scale screening for new therapeutic compounds to prevent and halt the progression of PD. While a fraction of all PD cases have known monogenic correlates, the majority cases are sporadic, with no recognized cause. In these cases, PD cannot be predicted and diagnosis is only made following the onset of symptoms, so even with significant advances in halting the progression of DA neuronal loss, there is and will continue to be a need for late-stage treatment options. Transplantation of human DA neurons is one such option. While most prior transplantation models for PD therapy graft cells directly into the target striatum, it should be remembered that DA neurons are part of a circuit, so ideal transplantation would graft DA neurons into the striatum and coax them to innervate the striatum thus rebuilding the native circuit. A major challenge to this type of advanced transplantation is the ability to accurately control the outgrowth and guidance of DA neurites. This requires detailed knowledge of the axon guidance cues that these particular neurons normally respond to, and how these responses may change in the context of severe neuroinflammation present in the diseased and post-op brain. Utilizing an in-vitro COS-cell aggregate outgrowth assay, we demonstrate that ESC-derived human midbrain DA neurons are attracted to gradients of netrin-1 and repelled by gradients of slit-2 in a manner that is similar to primary rat midbrain DA neurons. While these responses were not abolished in the presence of inflammatory cytokines, the response to netrin-1 was modified. These findings suggest that the outgrowth and innervation of transplanted human ESC/iPSC-derived DA neurons may be targeted by application of exogenous guidance factors, or manipulation of endogenous guidance factors and inflammatory cytokines in order to achieve better therapeutic outcomes. Further development these of human ESC and iPSC derived midbrain DA neuron models are likely to lead to major advances in our understanding of the basic developmental and functional neurobiology of DA neurons, and how these features are disrupted in disease processes like PD.
  • Digital
    edited by Sid M. Becker.
    Digital : ScienceDirect2017
    Molecular simulations of complex membrane models / D. Jefferies and S. Khalid -- Microbial strategies for oil biodegradation / G.E. Kapellos -- Modeling and measurement of biomolecular transport and sensing in microfluidic cell culture and analysis systems / J.F. Wong, C.A. Simmons and E.W.K. Wong -- Coupling microscale transport and tissue mechanics / M. Marino, G. Pontrelli, G. Vairo, and P. Wriggers -- Modeling cystic fibrosis and mucociliary clearance / R. Chatelin, D. Anne-Archard, M. Murris-Espin, D. Sanchez, M. Thiriet, A. Didier, and P. Poncet -- Intracellular microfluid transportation in fast growing pollen tubes / S. Liu, H. Liu, M. Lin, F. Xu, and T.J. Lu -- Microorganisms and their response to stimuli / R.J. Clarke -- Nano-swimmers in lipid-bilayer membranes / M.-J. Huang and A. Mikhailov -- Phase field modeling of Inhomogeneous biomembranes in flow / S. Aland -- Modeling and experimental analysis of thermal therapy during short pulse laser irradiation / S. Miller, C. Gross Jones, and K. Mitra -- Micro-scale bio-heat diffusion using green's functions / F. De Monte and A. Haji-Sheikh -- Microstructural influences on growth and transport in biological tissue / L. Irons, J. Collis, and R.D. O'Dea -- How dense core vesicles are delivered to axon terminals / I.A. Kuznetsov and A.V. Kuznetsov -- Modeling of food digestion / S. Marze.
  • Digital
    D. Alistair Steyn-Ross, Moira Steyn-Ross, editors.
    Digital : Springer2010
    Phase transitions in single neurons and neural populations: Critical slowing, anesthesia, and sleep cycles -- Generalized state-space models for modeling nonstationary EEG time-series -- Spatiotemporal instabilities in neural fields and the effects of additive noise -- Spontaneous brain dynamics emerges at the edge of instability -- Limited spreading: How hierarchical networks prevent the transition to the epileptic state -- Bifurcations and state changes in the human alpha rhythm: Theory and experiment -- Inducing transitions in mesoscopic brain dynamics -- Phase transitions in physiologically-based multiscale mean-field brain models -- A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep -- What can a mean-field model tell us about the dynamics of the cortex? -- Phase transitions, cortical gamma, and the selection and read-out of information stored in synapses -- Cortical patterns and gamma genesis are modulated by reversal potentials and gap-junction diffusion.
  • Digital
    Trachette L. Jackson, editor ; foreword by Luisa Iruela-Arispe.
    Digital : Springer2012
  • Digital
    Werner Krabs, Stefan Wolfgang Pickl.
    Digital : Springer2007
  • Digital
    Ewart Carson, Caludio Cobelli.
    Digital : ScienceDirect2015
    1. An introduction to modelling methodology / Claudio Cobelli and Ewart Carson -- 2. Control in physiology and medicine / B. Wayne Bequette -- 3. Deconvolution / Giovanni Sparacino [and three others] -- 4. Structural identifiability of biological and physiological systems / Maria Pia Saccomani -- 5. Parameter estimation / Paolo Magni and Giovanni Sparacino -- 6. New trends in nonparametric linear system identification / Gianluigi Pillonetto and Giuseppe De Nicolao -- 7. Population modelling / Paolo Magni, Alessandra Bertoldo and Paolo Vicini -- 8. Systems biology / Ruoting Yang [and three others] -- 9. Reverse engineering of high-throughput genomic and genetic data / Barbara Di Camillo and Gianna Toffolo -- 10. Tracer experiment design for metabolic fluxes estimation in steady and nonsteady state / Andrea Caumo and Claudio Cobelli -- 11. Stochastic models of physiology / Boris Kovatchev and Stephen Patek -- 12. Probabilistic modelling with Bayesian networks / Francesco Sambo, Fulvia Ferrazzi and Riccardo Bellazzi -- 13. Mathematical modelling of pulmonary gas exchange / Dan S. Karbing [and three others] -- 14. Mathematical models for computational neuroscience / Mauro Ursino, Filippo Cona and Elisa Magosso -- 15. Insulin modelling / Morten Gram Pedersen and Claudio Cobelli -- 16. Glucose modelling / Chiara Dalla Man and Claudio Cobelli -- 17. Blood-tissue exchange modelling / Paolo Vicini and James B. Bassingthwaighte -- 18. Physiological modelling of positron emission tomography images / Alessandra Bertoldo and Claudio Cobelli -- 19. Tumor growth modelling for drug development / Monica Simeoni [and four others] -- 20. Computational modelling of cardiac biomechanics / Emiliano Votta and Alberto Redaelli -- 21. Downstream from the heart left ventricle : aortic impedance interpretation by lumped and tube-load models / Roberto Burattini -- 22. Finite element modelling in musculoskeletal biomechanics / Zimi Sawacha and Bernhard Schrefler -- 23. Modelling for synthetic biology / Lorenzo Pasotti, Susanna Zucca and Paolo Magni.
  • Digital
    Andrea Strasser, Hans-Joachim Wittmann.
    Digital : Springer2013
    This practical introduction to molecular modelling of GPCRs covers core principles, and moves on to present advanced GPCR modelling techniques. Includes data on crystal structures and essential amino acid sequences, as well as LINUX commands and examples.
  • Digital
    edited by Edwin Michael, Robert C. Spear.
    Digital : Springer2010
    Print2010
    Progress in modelling malaria transmission -- Vector transmission heterogeneity and the population dynamics and control of lymphatic filariasis -- Modelling multi-species parasite transmission -- Metapopulation models in tick-borne disease transmission modelling -- Modelling stochastic transmission processes in helminth infections -- Modelling environmentally-mediated infectious diseases of humans: transmission dynamics of schistosomiasis in China -- Parameter estimation and site-specific calibration of disease transmission models -- Modelling malaria population structure and its implications for control -- Mathematical modelling of the epidemiology of tuberculosis -- Modelling trachoma for control programmes -- Transmission models and management of lymphatic filariasis elimination -- Disease transmission models for public health decision-making : designing intervention strategies for Schistosoma japonicum -- Modelling climate change and malaria transmission -- Modelling the transmission of Trypanosoma cruzi : the need for an integrated genetic epidemiological and population genomics approach.
  • Digital
    Lang Tran, Miguel A. Bañares, Robert Rallo, editors.
    Digital : Springer2017
    Print2017
    In today's nanotechnology and pharmaceutical research, alternative toxicology testing methods are crucial for ethically and commercially sound practice. This book provides practical guidelines on how to develop and validate quantitative nanostructure-toxicity relationship (QNTR) models, which are ideal for rapidly exploring the effects of a large number of variables in complex scenarios. Through contributions by academic, industrial, and governmental experts, Modelling the Toxicity of Nanoparticles delivers clear instruction on these methods and their integration and use in risk assessment. Specific topics include the physico-chemical characteristics of engineered nanoparticles, nanoparticle interactions, in vivo nanoparticle processing, and more. A much-needed practical guide, Modelling the Toxicity of Nanoparticles is a key text for researchers as well as government and industry regulators.
  • Digital
    Bhaskar DasGupta and Jie Liang.
    Digital : Wiley2016
  • Digital
    edited by Rahul Banerjee, Bikas K. Chakrabarti.
    Digital : ScienceDirect2008
    How to separate conceptual issues from empirical ones in the study of consciousness / M. Velmans -- The disunity of consciousness / S. Zeki -- Consciousness: the radical plasticity thesis / A Cleeremans -- A higher order Bayesian decision theory of consciousness / H. C. Lau -- Subjective measures of unconscious knowledge / Z. Dienes -- Interdependence of attention and consciousness / N. Srinivasan -- Computational studies of consciousness / I. Aleksander, H. Morton -- Identification of neuroanatomical substrates of set-shifting ability: evidence from patients with focal brain lesions / P. Mukhopadhyay ... [et. al] -- Thinking is believing / R. Kasturirangan -- The emergence of mind and brain: and evolutionary, computational, and philosophical approach / K. Mainzer -- Dynamic geometry, brain function modeling, and consciousness / S. Roy, R. Llinás -- Understanding the mind of a worm: hierarchial network structure underlying nervous system function in C. elegans / N. Chatterjee, S. Sinha -- Neural network modeling / B.K. Chakrabarti, A. Basu -- Retinomorphic image processing / K. Ghosh, K. Bhaumik, S. Sarker -- Modeling the sub-cellualer signaling pathways involved in reinforcement learning at the straitum / S.M. Wanjerkhede, R.S. Bapi -- Rythmic structure of Hindi and English: new insights from a computational analysis / T. Das, L. Singh, N.C. Singh -- Empirical perspectives from the self-model theory of subjectivity: a brief summary with examples / T. Metzinger -- Vipassana: the Buddha's tool to probe mind and body / D.V. Chavan -- Buddha and the bridging relations / R. Banerjee.
  • Digital
    volume editors, Ulf Sjöbring, John D. Taylor.
    Digital : Karger2007
    Print2007
    Exacerbations of asthma and COPD: definitions, clinical manifestations, and epidemiology / O'Byrne, P.M. -- Human rhinovirus models in asthma / Singh, A.M., Busse, W.W. -- Allergen inhalation challenge: a human model of asthma exacerbation / Gauvreau, G.M., Evans, M.Y. -- Cellular and animals models for rhinovirus infection in asthma / Xatzipsalti, M., Papadopoulos, N.G. -- Modeling responses to respiratory house dust mite exposure / Cates, E.C. ... [et al.] -- Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma / Lukacs, N.W. ... [et al.] -- Lipopolysaccharide challenge of humans as a model for chronic obstructive lung disease exacerbations / Kharitonov, S.A., Sjöbring, U. -- A human rhinovirus model of chronic obstructive pulmonary disease exacerbations / Contoli, M. ... [et al.] -- Animal models of cigarette smoke-induced chronic obstructive lung disease / Churg, A., Wright, J.L. -- Animal models of chronic obstructive pulmonary disease exacerbations / Gaschler, G.J. ... [et al.].
  • Digital
    Alireza Ghahari, John D. Enderle.
    Digital : Atypon2014
    There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book series is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In Part 1, early models of saccades and smooth pursuit are presented. A number of oculomotor plant models are described therein beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th-order oculomotor plant model. In Part 2, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. In this book, a multiscale model of the saccade system is presented, focusing on the neural network. Chapter 1 summarizes a whole muscle model of the oculomotor plant based on the 2009 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. Chapter 2 presents a neural network model of biophysical neurons in the midbrain for controlling oculomotor muscles during horizontal human saccades. To investigate horizontal saccade dynamics, a neural circuitry, including omnipause neuron, premotor excitatory and inhibitory burst neurons, long lead burst neuron, tonic neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed. A generic neuron model serves as the basis to match the characteristics of each type of neuron in the neural network. We wish to express our thanks to William Pruehsner for drawing many of the illustrations in this book.
  • Digital
    Ghahari, Alireza; Enderle, John D.
    Digital : Atypon2015
  • Digital
    John D. Enderle.
    Digital : Atypon2010
    There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, early models of saccades and smooth pursuit are presented. The smooth pursuit system allows tracking of a slow moving target to maintain its position on the fovea. Models of the smooth pursuit have been developed using systems control theory, all involving a negative feedback control system that includes a time delay, controller and plant in the forward loop, with unity feedback. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The oculomotor plant consists of three muscle pairs and the eyeball. A number of oculomotor plant models are described here beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th order oculomotor plant model. The work presented here is not an exhaustive coverage of the field, but focused on the interests of the author. In Part II, a state-of-art model of the saccade system is presented, including a neural network that controls the system.
  • Digital
    John D. Enderle, Wei Zhou.
    Digital : Atypon2010
    There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The control of saccades is initiated by the superior colliculus and terminated by the cerebellar fastigial nucleus, and involves a complex neural circuit in the mid brain. This book is the second part of a book series on models of horizontal eye movements.
  • Digital
    edited by Gianfranco Pancino, Guido Silvestri, Keith R. Fowke.
    Digital : ScienceDirect2011
    Natural SIV infection : virological aspects / Jan Münch and Frank Kirchhoff -- Natural SIV infection : immunological aspects / Béatrice Jacquelin, Roland C. Zahn, Françoise Barré-Sinoussi, Jörn E. Schmitz, Amitinder Kaur and Michaela C. Müller-Trutwin -- Implications for therapy / Ivona Pandrea and Alan L. Landay -- Are some people protected against HIV infection? / Mario Clerici, Mara Biasin and Gene M. Shearer -- The genital mucosa, the front lines in the defense against HIV / T. Blake Ball and Kristina Broliden -- Host genetics and resistance to HIV-1 infection / Ma Luo, Paul J. McLaren and Francis A. Plummer -- The immune system and resisting HIV infection / Keith R. Fowke, Catherine M. Card and Rupert Kaul -- Definition, natural history and heterogeneity of HIV controllers / Asier Sáez-Cirión, Gianfranco Pancino and Olivier Lambotte, for the ANRS CO18 Cohort -- Residual viremia and viral reservoirs in elite controllers / Robert W. Buckheit III and Joel N. Blankson -- Immune responses associated to viral control / Florencia Pereyra and Bruce D. Walker -- Immune mechanisms of viral control in HIV-2 infection / Eirini Moysi, Thushan de Silva and Sarah Rowland-Jones -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease / Jacques Fellay and Amalio Telenti.
  • Digital
    editors, Asla Pitkänen, Philip A. Schwartzkroin, Solomon L. Moshé.
    Digital : ScienceDirect2006
    Print2006
  • Digital
    edited by Richard D. Urman, Alan D. Kaye.
    Digital : Cambridge2012
    A concise, practical handbook giving up-to-date, evidence based, 'how to' guidance on safe, effective procedural sedation.
  • Digital
    edited by John Y. M. Koo, Ethan C. Levin, Argentina Leon, Jashin J. Wu, Alice B. Gottlieb.
    Digital : CRCnetBASE2014
    An overview of psoriasis / M. Alan Menter -- Evaluating psoriasis in patients / John Y. M. Koo, Jonathan W. Kowalski, Mark G. Lebwohl, Chris M. Kozma, M. Alan Menter, and Charles N. Ellis -- Topical agents / Rosemary deShazo, Gerald G. Krueger, and Kristina Callis Duffin -- The art and practice of UVB phototherapy and lasers / Monica Huynh, Maya G. Debbaneh, Ethan Levin, and John Y. M. Koo -- Systemic and topical PUVA therapy / Warwick L. Morison and Elizabeth G. Richard -- Goeckerman therapy / Rishu Gupta and John Y. M. Koo -- Combination, rotational, and sequential therapies / Jason Emer and Mark G. Lebwohl -- Systemic retinoids / Daniel Butler, Tina Bhutani, Ethan Levin, Eva Wang, and John Y. M. Koo -- Methotrexate / Gerald D. Weinstein and Edward W.B. Jeffes III -- Cyclosporine / Ethan Levin and Charles N. Ellis -- Etanercept / Shannon Famenini, Erik Y. Sako, Daniel C. Butler, and Jashin J. Wu -- Adalimumab / Maya G. Debbaneh and John Y. M. Koo -- Ustekinumab / Andrew Blauvelt -- Infliximab / Ethan Levin, John Y. M. Koo, and Alice Gottlieb -- Biologic fatigue / Ethan Levin and John Y. M. Koo -- IL-17 and other new agents / Ethan Levin, Argentina Leon, and John Y. M. Koo -- Erythrodermic and pustular psoriasis / Ethan Levin, Erik Y. Sako, Shannon Famenini, and Jashin J. Wu -- Pediatric psoriasis / Lauren Becker, Kelly M. Cordoro, Amy S. Paller -- Psoriatic arthritis / Dafna D. Gladman -- Special patient populations / Daniel C. Butler, Faranak Kamangar, Ethan Levin, John Y. M. Koo, and Anne S. Chang -- Current and potential applications of pharmacogenetics and pharmacogenomics / Rishu Gupta, Wilson Liao, John Y. M. Koo, and Jashin J. Wu -- The immunomodulatory/immunosuppressive classification system / John Y. M. Koo.
  • Digital
    Jürgen Schüttler, Helmut Schwilden, editors ; contributors J. Ahonen ... [et al.].
    Digital : Springer2008
  • Digital
    Lorenzo Drago, editor.
    Digital : Springer2017
    The concept of biofilm-related implant malfunction and "low-grade infection" -- Mechanisms of bacterial colonization of implants and host response -- Animal models of implant-related low-grade infections, a twenty-year review -- Microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- The role of biomarkers for the diagnosis of implant-related infections in orthopaedics and trauma -- Antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Prosthetic joint infections and cost analysis? -- Algorithm to diagnose delayed and late PJI: role of joint aspiration -- Erratum: microbiological diagnosis of implant-related infections: scientific evidence and cost/benefit analysis of routine antibiofilm processing -- Erratum: antibacterial bioactive glass, S53P4, for chronic bone infections- a multinational study -- Index.
  • Digital
    volume editor, Thomas Kohnen.
    Digital : Karger2002
    Print2002
    Topical anaesthesia for small incision cataract surgery / Bellucci, R. -- Why viscoadaptives? Are they really new? / Arshinoff, S.A. -- Comparison of four visocelastic substances for cataract surgery in eyes with cornea guttata / Mester, U.; Hauck, C.; Anterist, N.; Löw, M. -- The Staar wave / Fine, I.H.; Hoffman, R.S.; Packer, M. -- Phacotmesis / Kamman, J.; Dornbach, G. -- Tilt and tumble phacoemulsification / Davis, E.A.; Lindstrom, R.L. -- Phacoemulsification in the anterior chamber: preliminary results / Alio,́ J.L.; Shalaby, A.M.M.; Attia, W.H.-- Phaco chop: making the transition / Friedman, N.M.; Kohnen, T.; Koch, D.D. -- Ultrasound-assisted phaco aspiration / Olson, R.J. -- Management of the mature cataract / Masket, S. -- Phacoemulsification in the vitreous cavity / Ruiz-Moreno, J.M.; Alio,́ J.L. -- Capsular tension ring as adjuvant in phacoemulsification surgery / Munõz, G.; Alio,́ J.L.-- Optical coherence biometry / Haigis, W.-- Optical biometry in cataract surgery / Findl, O. et al -- White-to-white corneal diameter measurements using the eyemetrics program of the Orbscan Topography Systems / Wang, L.; Auffarth, G.U.-- Injector systems for foldable intraocular lens implantation / Fabian, E.-- Incisions for implantation of fordable intraocular lenses / Kohnen, T.-- Scheimpflug imaging of modern foldable high-refractive silicone and hydrophobic acrylic intraocular lenses / Baumeister, M.; Buḧren, J.; Kohnen, T.-- Does the PCO preventing square edge concept apply to acrylic-hydrophilic intraocular lenses? / Jaullery, S.; Sourdille, P.-- Posterior capsule opacification after implantation of polyfluorocarbon-coated intraocular lenses: a long term follow-up / Auffarth, G.U. et al -- Piggyback intraocular lens implantation / Gills, J.P.; Fenzl, R.E.-- Multifocal intraocular lenses / Claoue,́ C.; Parmar, D.
  • Digital
    Peter Hu, Madhuri Hegde, Patrick Alan Lennon, editors.
    Digital : Springer2012
    Part 1. Current Molecular Laboratory Methods -- Specimen Collection, Handling, and Processing / Lindsy Hengesbach and John A. Gerlach -- DNA/RNA Isolation and Quantitation / Jing Wang -- Test Validation / Cindy McCloskey and S. Terence Dunn -- In Vitro Amplification Methods in Molecular Diagnostics / C. Alexander Valencia and Bradford Coffee -- Whole Genome Sequencing in the Clinical Laboratory / Tina Hambuch, Brad Sickler, Arnold Liao, Suneer Jain and Philip D. Cotter -- Estimation of Exon Dosage Using Real-Time Quantitative Polymerase Chain Reaction / Applications to Factor VIII Gene in Hemophilia A and Endoglin/ACVRL1 Genes in Hereditary Hemorrhagic Telangiectasia / Juliana Purrazzella and Arupa Ganguly -- Reporting Clinical Molecular Genetic Laboratory Results / Victor Wei Zhang and Lora J. H. Bean -- Part 2. Clinical Molecular Infectious Disease Testing -- HIV-1 Genotyping and Virtual Phenotyping / Fangling Xu and Jianli Dong -- COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test, Version 2.0 / Tavat A. Buraruk and Charles E. Stager -- Hepatitis C Virus (HCV) Genotype Assay (LiPA) / Charles E. Stager and Tavat A. Buraruk -- COBAS® AmpliPrep/COBAS® TaqMan® HCV Test / Charles E. Stager and Tavat A. Buraruk -- Epstein-Barr Virus and Cytomegalovirus Viral Load Monitoring by Quantitative Real-Time Polymerase Chain Reaction / Su S. Chen, Seema Hai, Margaret L. Gulley and Rajyalakshmi Luthra -- Quantification of BK Viral Load / Hai Wu and Jianli Dong -- Molecular Diagnosis and Epidemiology of Rabies / Rodney E. Rohde and Bonny C. Mayes -- Pyrosequencing for Bacterial Identification / Laura Millecker and Ruth Ann Luna -- Other Pathogens of Significant Public Health Concern / Chris L. McGowin, Rodney E. Rohde and Greg C. Whitlock -- Part 3. Clinical Molecular Oncology Testing -- Gene Rearrangements Testing / Siby Sebastian, Juan Du and Rizwan Naeem -- Mutation Analysis in Cancer / Keyur Pravinchandra Patel, John Galbincea and Rajyalakshmi Luthra -- Minimal Residual Disease / Wesley O. Greaves and Rajyalakshmi Luthra -- Pyrosequencing in Cancer / Shalini Verma, Bedia A. Barkoh and Rajyalakshmi Luthra -- Clinical Applications of Microarrays in Cancer / Marilyn M. Li, Ankita Patel and Xiaofeng Hu -- Basic Theories and Clinical Applications of Molecular Flow Cytometry / Hua-Kang Wu, Hongli Chen and Peter C. Hu -- Part 4. Clinical Molecular Pre/Postnatal Testing -- Molecular Prenatal Diagnostic Testing / Joanna Wiszniewska and Christine M. Eng -- PCR Based Diagnosis of Fragile X Syndrome / Daniel J. Dykas and Allen E. Bale -- Part 5. Human Identity Testing -- Microsatellite Testing Short Tandem Repeat Profile Generation / Robin DeVille Guidry and Laura Gahn -- Parentage / Laura Gahn and Robin DeVille Guidry -- Part 6. Clinical Molecular Training -- Diagnostic Molecular Training / Peter C. Hu, Patrick Alan Lennon and Madhuri R. Hegde -- Molecular Diagnostics Point of Care Testing Training / Chang W. Lee and Peter C. Hu.
  • Digital
    Wan Tang, Xin Tu, editors.
    Digital : Springer2013
    This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens. The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.
  • Digital
    [edited by] Zhaohui Wu, Huajun Chen, Xiaohong Jiang, Zhejiang University, Hangzhou, China.
    Digital : ScienceDirect2012
    Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists. Introduces novel network technologies to Traditional Chinese Medicine informaticsProvides theory and practical examples and case studies of new techniques.
  • Digital
    edited by Fabien DeMeester, Sherma Zibadi, and Ronald Ross Watson.
    Digital : Springer2010
    Western diet and behavior: the Columbus concept -- The social context of dietary behaviors: the role of social relationships and support on dietary fat and fiber intake -- Social class, food intakes and risk of coronary artery disease in the developing world: the Asian paradox -- Social, cultural, economical, and practical factors -- Partially hydrogenated fats in the US diet and their role in disease -- Fatty acid ratios in free-living and domestic animals -- Is saturated fat bad? -- Alteration of human body composition and tumorigenesis by isomers of conjugated linoleic acid -- Insulin resistance and non-alcoholic fatty liver disease induced by conjugated linoleic acid in humans -- Dietary fat intake: promotion of disease in carotid artery disease: lipid lowering versus side effects of statins -- Recent cholesterol-lowering drug trials: new data, new questions -- Leptin and obesity: role in cardiac structure and dysfunction -- Cardiac structural and functional changes in genetically modified models of obesity -- Fat-modified dairy products and blood lipids in humans -- Modified milk fat reduces plasma triacylglycerol concentrations: health and disease effects -- Dietary supplements, cholesterol and cardiovascular disease -- Ill health effects of food lipids: consequences of inadequate food processing, storage and cooking -- Mycotoxins in human diet: a hidden danger -- Nutrition-toxicological dilemma on fish consumption -- Anthropogenic and naturally produced contaminants in fish oil: role in ill health -- Do modern Western diets play a role in myalgic encephalomyelitis? -- The role of modern Western diets in Attention-Deficit Hyperactivity Disorder -- The role of dietary rat in insulin resistance and type 2 diabetes -- Strategies to modify school-based foods to lower obesity and disease risk -- Selenium enigma: health implications of an inadequate supply -- Homocysteine: role in cardiovascular disease -- Dietary plant extracts to modify effects of high fat modern diets in health promotion -- Don't diet: adverse effects of the weight centered health paradigm -- Physical activity in diet-induced disease causation and prevention in women and men.
  • Print
    by Eugene Lepeschkin ; foreword by Frank N. Wilson.
    Print1951-
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Vangelis Sakkalis.
    Digital : Springer Protocols2014
    Modern Electroencephalographic Assessment Techniques: Theory and Applications presents numerous signal processing and connectivity analysis methodologies addressing a wide variety of clinical applications including epilepsy, schizophrenia, Alzheimer's disease and even alcoholism. Among the different topics addressed, the neurophysiological basis of cognitive processes is also investigated. The goal is to provide a comprehensive overview of the most modern and widely established approaches mainly applied in, but not limited to, decomposing high resolution multichannel Electroencephalography (EEG) and Magnetoencephalography (MEG) signals into functional interconnected brain regions. Synergistic approaches linking both EEG/ MEG and functional Magnetic Resonance Imaging (fMRI) techniques are also discussed. In line with the popular Neuromethods series, chapters present the theoretical basis of each method along with prosperous application domains, in the form of a balanced mixture of theoretical tutorials, comprehensive reviews and original research. Emphasis is given to the underlying assumptions, to technical matters that greatly affect the outcome of each proposed method, to the ambitions and to the domain of application of each method. Furthermore, links to graph theory and visualization of connectivity motifs is also addressed in an attempt to better describe the functional characteristics of brain networks.Authoritative and practical, Modern Electroencephalographic Assessment Techniques: Theory and Applications touches upon both the biomedical and computational aspects of this exciting and rapidly evolving field and will allow for a more in-depth, vital understanding of the brain's complex underlying mechanisms.
  • Print
    [edited by] Kenneth J. Rothman, Sander Greenland, Timothy L. Lash.
    Print2008
    Status: Not Checked OutLane Catalog Record
    Introduction / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Section I: Basic concepts -- Causation and causal inference / Kenneth J. Rothman ... [et al.] -- Measures of occurrence / Sander Greenland and Kenneth J. Rothman -- Measures of effect and measures of association / Sander Greenland, Kenneth J. Rothman, and Timothy L. Lash -- Concepts of interaction / Sander Greenland, Timothy L. Lash, and Kenneth J. Rothman -- Section II: Study design and conduct -- Types of epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Cohort studies / Kenneth J. Rothman and Sander Greenland -- Case-control studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Validity in epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Precision and statistics in epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Design strategies to improve study accuracy / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Causal diagrams / M. Maria Glymour and Sander Greenland -- Section III: Data analysis -- Fundamentals of epidemiologic data analysis / Sander Greenland and Kenneth J. Rothman -- Introduction to categorical statistics / Sander Greenland and Kenneth J. Rothman -- Introduction to stratified analysis / Sander Greenland and Kenneth J. Rothman -- Applications of stratified analysis methods / Sander Greenland -- Analysis of polytomous exposures and outcomes / Sander Greenland -- Introduction to bayesian statistics / Sander Greenland -- Bias analysis / Sander Greenland and Timothy L. Lash -- Introduction to regression models / Sander Greenland -- Introduction to regression modeling / Sander Greenland -- Section IV: Special topics -- Surveillance / James W. Buehler -- Using secondary data / Jørn Olsen -- Field methods in epidemiology / Patricia Hartge and Jack Cahill -- Ecologic studies / Hal Morgenstern -- Social epidemiology / Jay S. Kaufman -- Infectious disease epidemiology / C. Robert Horsburgh, Jr., and Barbara E. Mahon -- Genetic and molecular epidemiology / Muin J. Khoury, Robert Millikan, and Marta Gwinn -- Nutritional epidemiology / Walter C. Willett -- Environmental epidemiology / Irva Hertz-Picciotto -- Methodologic issues in reproductive epidemiology / Clarice R. Weinberg and Allen J. Wilcox -- Clinical epidemiology / Noel S. Weiss -- Meta-analysis / Sander Greenland and Keith O'Rourke.
  • Digital
    Dmitrij Frishman, Alfonso Valencia, editors.
    Digital : Springer2008
  • Digital
    edited by Reinhold Munker ... [et al.] ; foreword by H. Phillip Koeffler.
    Digital : Springer2006
    Basic biology of hemopoiesis / Reinhold Munker -- Molecular biology and cytokines / Reinhold Munker and Amanda Sun -- Supportive care in hematology / John Hiemenz and Reinhold Munker -- Transplantation of stem cells from bone marrow, peripheral blood and the umbilical cord / Ronald Paquette and Reinhold Munker -- Anemias: general considerations, microcytic, and megaloblastic anemias / Reinhold Munker -- Hemolytic anemias / Reinhold Munker ... [et al.] -- Leukocytosis, leukopenia, and other reactive changes of myelopoiesis / Reinhold Munker -- The myeloproliferative syndromes / Ronald Paquette, Erhard Hiller, and Reinhold Munker -- Acute myelogenous leukemias / Reinhold Munker -- Acute lymphoblastic leukemias / Reinhold Munker and Vishwas Sakhalkar -- Myelodysplastic syndromes / Ronald Paquette and Reinhold Munker -- Aplastic anemias / Ronald Paquette and Reinhold Munker -- Lymphocytosis, lymphopenia, lymphadenopathy, and splenomegaly / Reinhold Munker -- Hodgkin's lymphoma / Erhard Hiller and Reinhold Munker -- The non-Hodgkin's lymphomas / Reinhold Munker ... [et al.] -- Multiple myeloma and related paraproteinemias / Jonathan Glass and Reinhold Munker -- Congenital and acquired immunodeficiencies / Vishwas Sakhalkar and Reinhold Munker -- Infections relevant to hematology / Reinhold Munker -- Basic principles of hemostasis / Erhard Hiller -- Bleeding disorders / Erhard Hiller -- Thrombophilia, thromboembolic disease, and antithrombic therapy / Erhard Hiller -- Transfusion medicine and immunohematology / Grace C. Tenorio, Snehalata C. Gupte, and Reinhold Munker -- Storage disorders in hematology / Reinhold Munker.
  • Digital
    edited by Derek J.W. McMinn.
    Digital : Springer2009
    Development perspectives / Derek J.W. McMinn -- Materials and metallurgy / Tim J. Band -- Machining processes / Roger W.F. Ashton -- Hip joint tribology / Amir Kamali -- Corrosion and its contribution to metal release / Joseph Daniel and Amir Kamali -- Retrieval analysis / Tim J. Band, Roger W.F. Ashton, and Amir Kamali -- Cementing technique in Birmingham Hip Resurfacing / Stephen McMahon and Gabrielle Hawdon -- Migration studies / Arne Lundberg and Raed Itayem -- Vascularity of the femoral head in hip resurfacing / Stephen McMahon and Gabrielle Hawdon -- Femoral head blood supply studies / Nobuhiko Sugano, Takashi Nishii, and Takehito Hananouchi -- Acetabular bone conservation / Joseph Daniel, Hena Ziaee, and Derek J.W. McMinn -- Femoral DEXA studies in hip arthroplasty / Nobuhiko Sugano -- Metal ions / Joseph Daniel and Hena Ziaee -- Patient selection and timing of operation / Joseph Daniel, Chandra Pradhan, and Hena Ziaee -- Anesthesia, pain control, and thromboprophylaxis / Jonathan W. Freeman -- Anesthesia with special emphasis on pain control / Dennis R. Kerr and Lawrence Kohan -- Templating for the Birmingham Hip Resurfacing from conventional X-rays / Derek J.W. McMinn -- Computer templating of hip resurfacing arthroplasty / James Slover, Erik Wetter, and Henrik Malchau -- Partient positioning and exposure / Derek J.W. McMinn -- Acetabular preparation and insertion of the standard Birmingham Hip Resurfacing cup / Derek J.W. McMinn -- Acetabular preparation and insertion of the dysplasia Birmingham Hip Resurfacing cup / Derek J.W. McMinn -- Implantation of the femoral component of the Birmingham Hip Resurfacing / Derek J.W. McMinn -- Birmingham mid-head resection prosthesis and its implantation / Derek J.W. McMinn -- Guides, jigs, and navigation-assisted Birmingham Hip Resurfacing / Derek J.W. McMinn -- Management of complex anatomy / Joseph Daniel ... [et al.] -- Outcomes and standards for hip resurfacing / Callum W. McBryde and Paul B. Pynsent -- Results of Birmingham Hip Resurfacing in different diagnoses / Joseph Daniel ... [et al.] -- Complications and revisions of the Birmingham Hip Resurfacing / Chandra Pradhan, Joseph Daniel, and Hena Ziaee -- Rehabilitation after the Birmingham Hip Resurfacing / Anne Hands, Hena Ziaee, and Chandra Pradhan -- Recovery and rehabilitation / Lawrence Kohan and Dennis R. Kerr -- Final thoughts / Derek J.W. McMinn and James W. Pritchett.
  • Digital
    Alexander Kramer, Mirjam Kretzschmar, Klaus Krickeberg, editors.
    Digital : Springer2010
    Part 1. Challenges -- The Global Burden of Infectious Diseases / Paulo Pinheiro, Colin D. Mathers and Alexander Krämer -- Global Challenges of Infectious Disease Epidemiology / Alexander Krämer and Md. Mobarak Hossain Khan -- Emerging and Re-emerging Infectious Diseases / Thomas Löscher and Luise Prüfer-Krämer -- Infectious Disease Control Policies and the Role of Governmental and Intergovernmental Organisations / Gérard Krause -- Part 2. General concepts and methods -- Principles of Infectious Disease Epidemiology / Alexander Krämer, Manas Akmatov and Mirjam Kretzschmar -- Social Risk Factors / Klaus Krickeberg and David Klemperer -- Molecular Typing and Clustering Analysis as a Tool for Epidemiology of Infectious Diseases / Sylvia M. Bruisten and Leo Schouls -- Epidemiologic Surveillance / Ralf Reintjes and Klaus Krickeberg -- Outbreak Investigations / Ralf Reintjes and Aryna Zanuzdana -- Geographic Information Systems / Patrick Hostert and Oliver Gruebner -- Methods and Concepts of Epidemiology / Rafael Mikolajczyk -- Mathematical Models in Infectious Disease Epidemiology / Mirjam Kretzschmar and Jacco Wallinga -- Immunity to Infectious Diseases / Timo Ulrichs -- Principles and Practice of Vaccinology / Richard Pebody and Mirjam Kretzschmar -- Health Economics of Infectious Diseases / Robert Welte, Reiner Leidl, Wolfgang Greiner and Maarten Postma -- Part 3. Epidemiology of particular infectious diseases -- Airborne Transmission: Influenza and Tuberculosis / Timo Ulrichs -- Infectious Childhood Diarrhea in Developing Countries / Charles P. Larson, Lars Henning, Stephen Luby and Asg Faruque -- Bloodborne and Sexual Transmission: HIV/AIDS / Charlotte van den Berg, Karen Lindenburg and Roel Coutinho -- Blood Borne and Sexual Transmission: Hepatitis B and C / Freke Zuure, Susan Hahné, Thijs van de Laar, Maria Prins and Jim van Steenbergen -- Sexual Transmission: Chlamydia trachomatis / Robert E. Johnson and Stuart M. Berman -- Vector-Borne Transmission: Malaria, Dengue, and Yellow Fever / Tomas Jelinek -- Nosocomial Transmission: Methicillin-Resistant Staphylococcus aureus (MRSA) / M.J.M. Bonten and M.C.J. Bootsma -- Infectious Diseases and Cancer: HPV / Helen Trottier and Eduardo L. Franco.
  • Digital
    edited by Bernadette Bouchon-Meunier, Giulianella Coletti, Ronald R. Yager.
    Digital : ScienceDirect2006
    Entropies, characterizations, applications and some history / János Aczél -- Belief function theory on the continuous space with an application to model based classification / B. Ristic and Ph. Smets -- Independence in conditional possibility theory / G. Coletti and B. Vantaggi -- Joint treatment of imprecision and randomness in uncertainty propagation / C. Baudrit, D. Dubois, D. Guyonnet and H. Fargier -- Consistency of probabilistic transformations of belief functions / M. Daniel -- Randomization and uncertain inference / Henry E. Kyburg, Jr. and Choh Man Teng -- An empirical complexity study for a 2CPA solver / M. Baioletti, A. Capotorti and S. Tulipani -- Consistency in preference modelling / José Luis García-Lapresta and Javier Montero -- Transitive decomposition of min-transitive fuzzy relations / S. Díaz, B. De Baets and S. Montes -- Decision making with fuzzy ternary relations / S. Ovchinnikov -- New consistency properties for preference relations / F. Chiclana, E. Herrera-Viedma and F. Herrera -- Management of uncertainty orderings through ASP / Andrea Capotorti and Andrea Formisano -- Automating the quality assurance of an on-line knowledge-based classifier by fusing multiple off-line classifiers / Piero P. Bonissone -- Qualitative classification with possibilistic decision trees / Nahla Ben Amor, Salem Benferhat and Zied Elouedi -- Discovery of abstract knowledge from non-atomic attribute values in fuzzy relational databases / Rafal A. Angryk and Frederick E. Petry -- Kernel-based outlier preserving clustering with representativity coefficients / M.-J. Lesot -- Fuzzy C-medoids clustering models for time-varying data / R. Coppi, P. D'Urso and P. Giordani -- Improving the K2 algorithm using association rule parameters / Evelina Lamma, Fabrizio Riguzzi and Sergio Storari -- OWA aggregation on an interval argument / Ronald R. Yager -- On bi-capacity-based concordance rules in multicriteria decision making / A. Rolland -- Information evaluation in fusion : formalization of informal recommendations / Laurence Cholvy -- Application of uncertainty-based methods to fuse language identification expert decisions / J. Gutiérrez, J.-L. Rouas and R. André-Obrecht -- Intelligent multiattribute decision support model for medical triage / F. Burstein, Jocelyn San Pedro, Leonid Churilov and Jeff Wassertheil -- Interval-based multicriteria decision making / Martine Ceberio and François Modave -- A linguistic hierarchical evaluation model for engineering systems / L. Martínez, L.G. Pérez, J. Liu, J.B. Yang and F. Herrera -- Non monotonic aggregates applying to fuzzy sets in flexible querying / Patrick Bosc and Ludovic Liétard -- Fuzzy spatial data modeling : an extended bitmap approach / Jörg Verstraete, Guy De Tré and Axel Hallez -- Introducing [lambda]-specialization into the fuzzy EER model / Guoqing Chen, Ling Lin and Xunhua Guo -- A logical reasoning framework for modelling and merging uncertain semi-structured information / Anthony Hunter and Weiru Liu -- Machine learning and the prediction of protein structure : the state of the art / Rita Casadio, Remo Calabrese, Emidio Capriotti, Mario Compiani, Piero Fariselli, Paola Marani, Ludovica Montanucci, Pier Luigi Martelli, Ivan Rossi and Gianluca Tasco -- Efficient and robust global amino acid sequence alignment with uncertain evolutionary distance / Matthias C.M. Troffaes -- Classifying biomedical spectra using stochastic feature selection and parallelized multi-layer perceptrons / N.J. Pizzi, R.L. Somorjai and W. Pedrycz -- On the sensitivity of probabilistic networks to reliability characteristics / Linda C. van der Gaag and Silja Renooij -- Dominance of recognition of words presented on right or left eye (comparison of kanji and hiragana) / Takahiro Yamanoi, Toshimasa Yamazaki, Jean-Louis Vercher, Elie Sanchez and Michio Sugeno -- Hand posture recognition with the fuzzy glove / T. Allevard, E. Benoit and L. Foulloy -- Image retrieval by composition of regions / J.F. Omhover and M. Detyniecki -- Blind image restoration from multiple views by IMAP estimation / Monia Discepoli, Ivan Gerace and Roberta Pandolfi -- A combined feature extraction method for an electronic nose / I. Hristozov, B. Iliev and S. Eskiizmirliler.
  • Digital
    Graham A. Webb (ed.).
    Digital : Springer2006
    Applications in chemistry, biological and marine sciences. pt. 1, [1-3] -- Applications in medical and pharmaceutical sciences. pt. 2, [4-5] -- Applications in materials science and food science. pt. 3, [6-7].
  • Digital
    volume editors, Jean Régis, Pierre-Hugues Roche.
    Digital : Karger2008
    Print2008
  • Digital
    Riccardo A. Audisio, James G. Geraghty, and Walter E. Longo, editors.
    Digital : Springer2015
  • Digital
    Yu-Kang Tu, Darren C. Greenwood, editors.
    Digital : Springer2012
    Confounding and causal path diagrams -- Statistical modelling of partially observed data using multiple imputation: principles and practice -- Measurement errors in epidemiology -- Selection bias in epidemiologic studies -- Multilevel modelling -- Modelling data that exhibit an excess number of zeros : zero-inflated models and generic mixture models -- Multilevel latent class modelling -- Bayesian bivariate disease mapping -- Multivariate random fraility effects model for multiple spatially dependent survival data -- Meta-analysis of observational studies -- Directed acyclic graphs and structural equation modelling -- Latent growth curve models -- Growth mixture modelling for life course epidemiology -- G-estimation for accelerated failure time models -- Generalised additive models -- Regression and classification trees -- Statistical interactions and gene-environment joint effects.
  • Print
    author, Roger E. Schirmer.
    Print1982-
    Status: Not Checked OutLane Catalog Record
  • Digital
    Kristin J. Anderson.
    Digital : OSO2014
    'Modern Misogyny' examines contemporary antifeminism in a 'postfeminist' era. It considers the widespread idea that the feminist movement has ended, it achieved what it set out to achieve and is irrelevant to contemporary women's lives. The book argues that equality has not been achieved and that sexism and discrimination are now packaged in a more palatable but stealthy form.
  • Digital
    Srinivasan Yegnasubramanian, William B. Isaacs, editors.
    Digital : Springer2010
    Genome-Scale Analysis of Data from High-Throughput Technologies / Sarah J. Wheelan -- Analysis of Inherited and Acquired Genetic Variation / Srinivasan Yegnasubramanian and William B. Isaacs -- Examining DNA-Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis / Esteban Ballestar and Manel Esteller -- Genome-Wide DNA Methylation Analysis in Cancer Research / Srinivasan Yegnasubramanian and William G. Nelson -- Use of Expression Microarrays in Cancer Research / Jun Luo and Yidong Chen -- Signal Sequencing for Gene Expression Profiling / Biaoyang Lin, Jeremy Wechsler and Leroy Hood -- Mass Spectrometry Based Proteomics in Cancer Research / Mohamad A. Abbani, Parag Mallick and Maryann S. Vogelsang -- Tissue Microarrays in Cancer Research / Toby C. Cornish and Angelo M. De Marzo.
  • Digital
    editors, A. Catharine Ross, Benjamin Caballero, Robert J. Cousins, Katherine L. Tucker, Thomas R. Ziegler.
    Digital : Ovid2014
    Part I. Specific Dietary Components -- A. Major dietary constituents -- B. Minerals -- C. Vitamins -- D. Other compounds with health relevance -- Part II. Nutritional Roles in Integrated Biological Systems -- A. Nutrient-gene mechanisms -- B. Digestive, endocrine, immune, and neural mechanisms -- Part III. Nutritional Needs and Assessment During the Life Cycle and Physiologic Changes -- Part IV. Prevention and Management of Disease -- A. Obesity and diabetes -- B. Cardiovascular diseases -- C. Pediatric and adolescent disorders -- D. Disorders of the alimentary tract -- E. Nutritional management during cancer -- F. Skeletal and joint disorders -- G. Nutrition in surgery and trauma -- H. Behavioral, psychiatric, and neurologic disorders -- I. Other systemic disorders -- J. Food additives, hazards, and nutrient-drug interactions -- Part V. Nutrition of Populations -- A. Nutrition in a changing world.
  • Digital
    Jim Kozubek, Brigham and Womenʹs Hospital, staff scientist, Department of Neurology Broad Institute of MIT and Harvard.
    Digital : Cambridge2016
    This book tells the dramatic story of Crispr and the potential impact of this gene-editing technology.
  • Digital
    Hamid Mirzaei, Martin Carrasco, editors.
    Digital : Springer2016
    Print2016
    Sample preparation strategies for proteomics. Proteomes, their compositions and their sources / Anna Kwasnik, Claire Tonry, Angela Mc Ardle, Aisha Qasim Butt, Rosanna Inzitari [and others] -- Protein fractionation and enrichment prior to proteomics sample preparation / Andrew J. Alpert -- Sample preparation for mass spectrometry-based proteomics; from proteomes to peptides / John C. Rogers, Ryan D. Bomgarden -- Plant structure and specificity: challenges and sample preparation considerations for proteomics / Sophie Alvarez, Michael J. Naldrett -- Improving proteome coverage by reducing sample complexity via chromatography / Uma Kota, Mark L. Stolowitz -- Mass spectrometry for proteomics analysis. Database search engines: paradigms, challenges and solutions / Kenneth Verheggen, Lennart Martens, Frode S. Berven, Harald Barsnes, Marc Vaudel -- Mass analyzers and mass spectrometers / Anthony M. Haag -- Top-down mass spectrometry: proteomics to proteoforms / Steven M. Patrie -- Bioinfomatic tools for proteomics data analysis and interpretation. Platforms and pipelines for proteomics data analysis and management / Marius Cosmin Codrea, Sven Nahnsen -- Tandem mass spectrum sequencing: an alternative to database search engines in shotgun proteomics / Thilo Muth, Erdmann Rapp, Frode S. Berven, Harald Barsnes, Marc Vaudel -- Visualization, inspection and interpretation of shotgun proteomics identification results / Ragnhild R. Lereim, Eystein Oveland, Frode S. Berven, Marc Vaudel, Harald Barsnes -- Protein inference / Zengyou He, Ting Huang, Can Zhao, Ben Teng -- Modification site localization in peptides / Robert J. Chalkley -- Useful web resources / Andre Bui, Maria D. Person -- Mass spectrometry-based protein quantification / Yun Chen, Fuqiang Wang, Feifei Xu, Ting Yang -- Bioinformatics tools for proteomics data interpretation / Karla Grisel Calderón-González, Jesús Hernández-Monge, María Esther Herrera-Aguirre [and others] -- Applications of proteomis technologies in biological and medical sciences. Identification, quantification, and site localization of protein posttranslational modifications via mass spectrometry-based proteomics / Mi Ke, Hainan Shen, Linjue Wang, Shusheng Luo, Lin Lin, Jie Yang, Ruijun Tian -- Protein-protein interaction detection via mass spectrometry-based proteomics / Benedetta Turriziani, Alexander von Kriegsheim, Stephen R. Pennington -- Protein structural analysis via mass spectrometry-based proteomics / Antonio Artigues, Owen W. Nadeau, Mary Ashley Rimmer, Maria T. Villar, Xiuxia Du [and others] -- Introduction to clinical proteomics / John E. Wiktorowicz, Allan R. Brasier -- Clinical proteomics. Discovery of candidate biomarkers / John E. Wiktorowicz, Kizhake V. Soman -- Statistical approaches to candidate biomarker panel selection / Heidi M. Spratt, Hyunsu Ju -- Qualification and verification of protein biomarker candidates / Yingxin Zhao, Allan R. Brasier -- Protocol for standardizing high-to-moderate abundance protein biomarker assessments through an mrm-with-standard-peptides quantitative approach / Andrew J. Percy, Juncong Yang, Andrew G. Chambers, Yassene Mohammed, Tasso Miliotis [and others].
  • Digital
    edited by Markku Miettinen.
    Digital : Cambridge2016
  • Digital
    [edited by] Noel Weidner [and others].
    Digital : ClinicalKeyv.1-2, 2009
    Part I: The Surgical Pathology Laboratory -- 1. Gross Room and Specimen Handling -- Lucien E. Nochomovitz -- 2. Intraoperative Consultations in Surgical Pathology -- Mahendra Ranchod -- 3. The Surgical Pathology Report -- Debra Hawes, Richard J. Cote, Noel Weidner -- 4. Anatomic Pathology Laboratory Information Systems -- Anil V. Parwani, Eric Schubert, William Gross, John Gilbertson, Michael J. Becich -- 5. Immunohistochemistry -- Debra Hawes, Shan-Rong Shi, David J. Dabbs, Clive R. Taylor, Richard J. Cote -- 6. Role of Electron Microscopy in Modern Diagnostic Surgical Pathology -- Robert A. Erlandson -- 7. Molecular Biology -- Sharon P. Wilczynski -- 8. The Essential Quality Improvement and Educational Programs in Surgical Pathology -- Robert R. Rickert -- 9. Medicolegal Issues in Surgical Pathology -- David B. Troxel -- Part 2: Head and Neck -- 10. Nasal Cavity, Paranasal Sinuses, and Nasopharynx -- Bruce M. Wenig, Mary Richardson -- 11. Larynx -- Lester D.R. Thompson -- 12. Salivary Glands -- Gary L. Ellis, Paul L. Auclair -- 13. Ear and Temporal Bone -- Bruce M. Wenig -- 14. Oral Cavity and Jaws -- Noel Weidner, Kurt Matthews, Joseph A. Regezi -- Part 3: Thoracic System -- 15. Lung -- Saul Suster, Cesar A. Moran -- 16. Serosal Membranes -- Lawrence M. Weiss -- 17. Mediastinum -- Saul Suster, Cesar A. Moran -- 18. Heart and Blood Vessels -- Allen Burke, Renu Virmani -- Part 4: Breast -- 19. Breast -- Noel Weidner -- Part 5: Gastrointestinal Tract -- 20. Esophagus -- Christopher A. Moskaluk -- 21. Stomach -- David Lewin, Klaus J. Lewin (deceased) -- 22. Small Intestine -- David Lewin, Klaus J. Lewin (deceased) -- 23. Large Intestine (Colon) -- Robert E. Petras, Wendy Frankel -- 24. Appendix -- Norman J. Carr, Leslie H. Sobin -- 25. Anus -- David A. Owen -- 26. Pancreas -- Ralph H. Hruban, Noriyoshi Fukushima, Robb E. Wilentz -- 27. Liver -- M. Kay Washington -- 28. Gallbladder and Extrahepatic Bile Ducts -- M. Kay Washington -- Part 6: Urinary Tract and Male Genital System -- 29. Non-Neoplastic Kidney -- Sharda G. Sabnis, Michael N. Koss, W.B. Ross, Zdena Pavlova -- 30. Renal Neoplasia -- John N. Eble, Liang Cheng -- 31. Bladder and Urethra -- Richard J. Cote, Anirban P. Mitra, Mahul B. Amin -- 32. Prostate -- David G. Bostwick, Isabelle Meiers -- 33. Penis and Scrotum -- Pheroze Tamboli, Antonio L. Cubilla, Mahul B. Amin -- 34. Testis and Paratestis Including Spermatic Cord -- Satish K. Tickoo, Pheroze Tamboli, Nancy E. Warner, Mahul B. Amin -- Part 7: Female Reproductive System -- 35. Vulva and Vagina -- Juan C. Felix, R. Tucker Burks, Charles A. Amezcua -- 36. Cervix -- Juan C. Felix, Thomas C. Wright, Jr., Charles A. Amezcua -- 37. Uterus -- Noel Weidner, Michael Peterson -- 38. Fallopian Tubes and Broad Ligament -- Noel Weidner, Michael Peterson -- 39. Ovaries -- Noel Weidner, Michael Peterson -- 40. Gestational Pathology -- Cynthia G. Kaplan -- Part 8: Hematolymphoid System -- 41. Lymph Nodes -- Karen L. Chang, Daniel A. Arber, Lawrence M. Weiss -- 42. Spleen -- Daniel A. Arber -- 43. Bone Marrow -- Daniel A. Arber -- Part 9: Endocrine System -- 44. Thyroid and Parathyroid -- Loretta L.Y. Tse, John K.C. Chan -- 45. Adrenal Gland -- Lawrence M. Weiss, Sean K. Lau -- Part 10: Soft Tissue and Skeletal System -- 46. Soft Tissues -- Lawrence M. Weiss -- 47. Joint and Bone Pathology -- Noel Weidner, Grace Y. Lin, Michael Kyriakos -- Part 11: Skin -- 48. Inflammatory Skin Conditions -- Još Antonio Plaza, Victor G. Prieto -- 49. Tumors of the Skin -- Saul Suster, Tai-Yuen Wong, Martin C. Mihm, Jr. -- Part 12: Nervous System -- 50. Pituitary -- David R. Hinton, Sylvia L. Asa -- 51. Central Nervous System Tumors -- Mahlon D. Johnson, James B. Atkinson -- 52. The Molecular and Genetic Basis of Neurodegenerative Diseases -- Thomas A. Tousseyn, Jeffrey P. Simko, David A. Gaskin, Stephen J. DeArmond -- 53. Muscle and Nerve Biopsy -- James B. Atkinson, Mahlon D. Johnson, Thomas W. Bouldin, William O. Whetsell, Jr. -- 54. Eye and Ocular Adnexa -- Somsiri Sukavatcharin, Narsing A. Rao.
  • Print
    Thorek, Max.
    Status: Not Checked OutLane Catalog Record
  • Print
    edited by Frankis T. Evans and T. Cecil Gray.
    Print1958-
    Status: Not Checked OutLane Catalog Record
  • Print
    [edited by] Edward E. Wallach, Roger D. Kempers ; under the auspices of the American Fertility Society.
    Print1979-
    Status: Not Checked OutLane Catalog Record
  • Print
    edited by John Apley.
    Print1974
    Status: Not Checked OutLane Catalog Record
  • Digital
    Anne Esacove.
    Digital : OSO2016
    Tracing the story of AIDS: an introduction to narrative, "African" AIDS and the U.S. prevention response -- Embodied risk: gender, modernity, & tradition -- Love matches: the policy prescription for "good" sex -- The sweetest sex possible...under the circumstances: the everyday prescription for "good" sex -- Prevention strategies: individualized & bureaucratic practices for creating modern actors -- Renarrating good sex: redirecting prevention.
  • Print
    Kristina M. Godek.
    Print2010
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by J. Vincent Edwards, Gisela Buschle-Diller, and Steven C. Goheen.
    Digital : Springer2006
  • Digital
    Paolo Gottarelli.
    Digital : Springer2012
    Humans can resist 40 days without eating and 4 days without drinking, but only 4 minutes without breathing: this tells us much about its fundamental importance. Breathed air is slowed down, filtered, warmed and humidified by the nose; many mechanisms are involved in this act, which prevent bronchial tubes and pulmonary alveolus from receiving an excessive and sudden air load. It is well known, on the other hand, that breathing through the mouth causes a lot of problems: inflammatory diseases of the upper airways, sleep apnea syndrome, but also, in some cases, bronchial, pulmonary and even cardiac disorders, that are more easily affecting patients not able to breathe correctly through the nose. For this reason, restoring an efficient nasal function is a very important - and in some cases crucial - issue. This book describes in details an innovative surgical technique called modified inferior turbinoplasty, which offers an excellent solution to the problems associated with the lower turbinate hypertrophy. A turbinate (or nasal concha) is a long, narrow, curled bone shelf that protrudes into the breathing passage of the nose. Most surgical interventions treat only the soft parts of hypertrophic turbinates using laser therapy, radiofrequency treatment, and electrocoagulation, but these procedures often lead to relapse. With this technique, in contrast, all anatomic parts of the turbinate are treated, including bone tissue: the surgeon reduces the inferior nasal concha and the internal nasal tissue, and the mucosa is then remodeled with sutures. The modified inferior turbinoplasty allows the complete avoidance of swabs in the nose, which is fundamental for patients well-being and grant them a quicker recovery. The book will be very useful for othorinolaryngologists, plastic surgeons, endoscopic and maxillofacial surgeons.
  • Digital
    Samantak Ghosh.
    Digital2010
    This thesis discusses a number of projects involving the use of modified nucleotides and oligonucleotides in addressing some basic science questions and some clinical and technological applications.The first chapter details our efforts at using telomere-encoding circular DNA in elongating zebrafish telomeres. We microinjected our synthetic circular DNA into zebrafish embryos and studied their telomere length 24 hrs later. Using Quantitative Fluorescence in situ Hybridization (Q-FISH) as the analytical tool to determine telomere length, we observed no significant difference in telomere length between the group injected with the synthetic DNA and the control group. In the second chapter we studied the potential of a non-polar shape mimic of iodo-uracil as an imager of tumors. We continued discussing our work with non-polar nucleotide isosteres in the third chapter where we used them in investigating a novel active site in polymerase from Pyrococcus furiosus (Pfu). From our studies we concluded that although shape was an important factor in distinguishing bases, this binding site also employed hydrogen bonding to identify nucleoabases. The lack of any recognition of the syn-oxidized bases suggested that the enzyme preferred to recognize bases in the anti conformation rather than syn. In the fourth chapter we were interested in understanding the factors determining the fidelity and selectivity observed in RNA Polymerase II mediated transcription. Once again we used non-polar shape mimics of thymidine (dF) and adenine (dQ) to study the importance of shape and hydrogen bonding. We observed that the thymidine mimic was recognized better by the RNA Polymerase II active site than the mis-match bases. The adenine isostere on the other hand, was poorly recognized. This preliminary study demonstrates the importance of both shape and hydrogen bonding. The last chapter discusses our studies using polyfluorophores on a DNA backbone to detect gases. Following a combinatorial method, a library of oligodeoxyfluorosides (ODFs) were synthesized from which sensors of gases were selected. Using this method we were able to select optical sensors for a diverse set of small molecules in vapor state.
  • Print
    Philip Martins Vitorino.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    edited by Mike Reading and Douglas J. Hourston.
    Digital : Springer2006
  • Digital
    Mark Ping Chao.
    Digital2010
    Growing evidence indicates that cancers are composed of functionally heterogeneous cells that are organized by a cellular hierarchy and are maintained by a stem cell-like population. Given their unique ability to initiate tumor growth, eradication of these cancer stem cells (CSC) is necessary for cure. Thus, the development of CSC targeted therapies is necessary to improve current clinical outcomes. This body of work identifies CD47 as a therapeutic target on CSC and bulk cells in several human malignancies. CD47 is a cell surface protein that functions to inhibit phagocytosis through binding its ligand SIRP[Alpha], expressed on phagocytes. Compared to normal cell counterparts, CD47 was highly expressed on several human tumors including acute myeloid leukemia (AML), acute lymphoblastic leukemia (ALL), and non-Hodgkin lymphoma (NHL), suggesting that higher CD47 levels on tumors allow evasion of immune phagocytosis. Higher CD47 expression in these tumors correlated with a worse clinical prognosis and was an independent prognostic factor. Furthermore, a monoclonal blocking antibody against CD47 enabled phagocytosis of human AML, ALL, and NHL in vitro and eliminated disease in vivo. When combined with the Fc receptor-activating antibody, rituximab, anti-CD47 antibody therapy achieved high cure rates in pre-clinical models of NHL in contrast to partial responses with either agent alone. Lastly, anti-CD47 antibody treatment specifically targeted tumor but not normal cells, resulting in minimal toxicity in vitro and in vivo. The selective targeting of tumor cells by anti-CD47 antibody was due to the selective expression of the pro-phagocytic signal, calreticulin on tumor but not normal cells. In summary, this body of work identifies CD47 as a therapeutic target on several human cancers and that a monoclonal blocking antibody against CD47 has pre-clinical efficacy in eliminating these tumors through the promotion of phagocytosis.
  • Print
    Erika Anne O'Donnell.
    Status: Not Checked OutLane Catalog Record
  • Digital
    Erica Machlin Cox.
    Digital2012
    Hepatitis C virus (HCV) is a global health problem, infecting approximately 2% of the world's population. The virus is hepatotropic, replicating in liver cells, and its only known hosts are humans and chimpanzees. HCV is an unusual virus in that it requires the liver-specific host microRNA (miRNA) miR-122 for HCV RNA accumulation. Though the precise mechanism by which miR-122 upregulates HCV RNA is still under investigation, it is known that miR-122 must bind to two adjacent sites in the 5' end of the HCV genome. In this dissertation, a stepwise mutational analysis of the entire sequence of miR-122 was performed to identify residues important for HCV RNA accumulation. All mutant miRNAs were tested in canonical miRNA reporter assays and in HCV RNA accumulation assays. The identities of two nucleotides within miR-122, at positions 15 and 16, were shown to be dispensable for canonical miRNA and siRNA activity but required for HCV RNA accumulation. Compensatory mutations in the HCV genome upstream of the original binding sites uncovered supplementary binding sites for nucleotides 15 and 16 of miR-122. This analysis led to a new model for miR-122-HCV RNA interactions. To further define the requirements of HCV for miR-122, we investigated whether the predecessor of mature miR-122, a long hairpin precursor designated pre-miR-122, was also able to mediate HCV RNA accumulation. The function of pre-miR-122 was tested in miRNA, siRNA, and HCV RNA accumulation assays. Inhibition of pre-miR-122 processing was achieved by substituting deoxyribonucleotides into the loop of pre-miR-122 to prevent Dicer-mediated cleavage. Full-length pre-miR-122 was demonstrated to be functional in miRNA and siRNA assays and to be sufficient for HCV RNA accumulation. Pre-miR-122 also required traditional components of the RNA-induced silencing complex (RISC) for activity. Taken together, this research has uncovered novel requirements of miR-122 for HCV RNA accumulation. Components shown to be dispensable for canonical miRNA interactions were necessary for this unusual microRNA-target RNA interaction. Uncovering hepatitis C virus's stringent requirements for the mature and precursor forms of miR-122 will pave the way for new antiviral therapies targeting a host factor.
  • Digital
    Gary Stephens, Sumiko Mochida, editors.
    Digital : Springer2013
    "This book brings together leading international experts to discuss recent advances in the regulation of presynaptic voltage-gated Ca2+ channels (VGCCs), key signal transducers that represent one of the most widely modulated proteins in the body. It is now commonly accepted that presence of the VGCC complex defines an excitable cell. At a basic level, VGCCs transduce membrane potential change to chemical neurotransmitter release at presynaptic terminals. However, on-going scientific research, presented here, in areas including neuroscience, electrophysiology, pharmacology, biochemistry and, increasingly, proteomics, has revealed the widespread nature of modulation of the presynaptic VGCC complex. This book reviews and discusses the following topics: The fundamental role of the VGCC pore-forming CaVa subunit, and some of their binding partners, in presynaptic function and synaptic plasticity. Modulation of presynaptic CaVa subunits by auxiliary CaVb and a2d subunits and by their major interaction partners, such as active zone scaffolding proteins, synaptic proteins, G proteins and small GTPases, which, together, contribute to the VGCC proteome. Work at the cutting edge of research, including how direct electrophysiology recordings from presynaptic terminals and introduction of synthetic CaVa peptides into presynaptic terminals has expanded our knowledge of VGCC function. Evidence emerging over the last decade demonstrating that VGCC subunits represent bona fide molecular targets for therapeutic drug discovery. This development is illustrated by the introduction of the CaV2.2 blocker ziconotide, which represents an important proof-of-concept, but is best exemplified by the emergence of gabapentinoids, which bind the VGCC auxiliary a2d subunit, as first-line treatments for chronic neuropathic pain. Throughout, chapters are accompanied with illustrative Tables and Figure providing a useful and comprehensive summary of the current state-of-play in this area of significant therapeutic interest. Work described here also provides a solid basis for future research in this important area." -- Back cover.
  • Digital
    Kathleen Sakamoto, Eric Rubin, editors.
    Digital : Springer2009
  • Digital
    Randall G. Fisher, Thomas G. Boyce.
    Digital : Ovid2005
    Print2005
    The diagnosis and management of infectious diseases -- Nose and throat syndromes -- Infectious mononucleosis and mononucleosis-like syndromes -- Mouth and salivary gland syndromes -- Eye, ear, and sinus syndromes -- Face and neck syndromes -- Middle respiratory syndromes -- Pneumonia syndromes -- Neurologic syndromes -- Fever and shock syndromes -- Rash syndromes -- Gastrointestinal syndromes -- Hepatitis syndromes -- Urinary syndromes -- Genital syndromes -- Orthopedic syndromes -- Skin syndromes -- Cardiovascular syndromes -- Perinatal syndromes -- HIV infection and AIDS -- Exposure problems -- Infections complicating chronic diseases -- The child with frequent, severe, or unusual infections: congenital immunodeficiency syndromes.
  • Digital
    Keyvan Nouri, editor.
    Digital : Springer2012
    An Introduction to Mohs Micrographic Surgery -- Indications for Mohs Micrographic Surgery -- Preoperative Evaluation -- Mohs Micrographic Surgery Operative Room Setup -- Anesthetic Considerations: Local Versus Regional -- Cutaneous Anatomy in Mohs Micrographic Surgery -- Mohs Surgery: Fixed Tissue Technique -- Fresh Tissue Technique -- Special Considerations for Mohs Micrographic Surgery in Organ Transplant Recipients -- Mohs Micrographic Surgery in Ethnic Skin -- Histopathology Laboratory Setup and Necessary Instrumentation -- Tissue Transport and Initial Processing Cryostat Preparation of Slides -- Histopathologic Interpretation of Mohs Slides -- Tissue Specimen Documentation, Record Keeping, and Sample Storage -- Immunostains -- Basal Cell Carcinoma -- Squamous Cell Carcinoma -- Mohs Micrographic Surgery for the Treatment of Cutaneous Melanoma -- Dermatofibrosarcoma Protuberans -- Microcystic Adnexal Carcinoma -- Atypical Fibroxanthoma -- Extramammary Paget Disease -- Leiomyosarcoma -- Merkel Cell Carcinoma -- Selected Sweat Gland Carcinomas -- Sebaceous Carcinoma -- Mohs Micrographic Surgery for the Eyelid -- Mohs Surgery for Periungual and Subungual Skin Cancer -- Genitalia -- Deep Structures of the Head and Neck -- Complications of Mohs Micrographic Surgery -- Eyelid Reconstruction After Mohs Micrographic Surgery -- Flaps -- Skin Grafting -- Side to Side Closure After Mohs Surgery -- Prosthetic Rehabilitation -- Combination Therapy for the Nonsurgical Treatment of Skin Cancers: Latest Research at Mount Sinai -- Training and Regulation in Mohs Surgery -- Establishing a Mohs Practice -- International Perspective of Mohs Micrographic Surgery: South America -- International Perspective of Mohs Micrographic Surgery: Europe -- International Perspective of Mohs Micrographic Surgery: East Asia -- International Perspective of Mohs Micrographic Surgery: Australia and New Zealand -- Information for Patients and Safety Considerations -- Ethical Issues Related to Mohs Skin Cancer Surgery -- Medicolegal Issues Regarding Mohs Micrographic Surgery -- Psychological Issues Regarding Mohs Micrographic Surgery.
  • Digital
    edited by Andreas Luch.
    Digital : Springer2009
  • Digital
    edited by Andreas Luch.
    Digital : Springer2010
  • Digital
    edited by Andreas Luch.
    Digital : Springer2012
    Chemical Hazards in the Organisation / Chris Winder -- Toxicology of Water / Xiaowei Zhang, Steve Wiseman and John Giesy -- Perfluorinated Compounds / Christopher Lau -- Toxicologically Relevant Phthalates in Food / Oliver Kappenstein, Bärbel Vieth, Andreas Luch and Karla Pfaff -- Exposure to Polycyclic Aromatic Hydrocarbons: Bulky DNA Adducts and Cellular Responses / Frank Henkler, Kristin Stolpmann and Andreas Luch -- Heavy Metal Toxicity and the Environment / Paul B. Tchounwou, Clement G. Yedjou, Anita K. Patlolla and Dwayne J. Sutton -- Toxicology of Ambient Particulate Matter / Damiën van Berlo, Maja Hullmann and Roel P. F. Schins -- Nanomaterials: A Challenge for Toxicological Risk Assessment? / Andrea Haase, Jutta Tentschert and Andreas Luch -- Immunotoxicology and Its Application in Risk Assessment /; Andrew A. Rooney, Robert W. Luebke, MaryJane K. Selgrade and Dori R. Germolec.; Chemical Sensitization and Allergotoxicology / Rosette L. Van Den Heuvel, Nathalie Lambrechts, Sandra Verstraelen, Inge C. Nelissen and Greet E. R. Schoeters -- Male Reprotoxicity and Endocrine Disruption / Sarah Campion, Natasha Catlin, Nicholas Heger, Elizabeth V. McDonnell and Sara E. Pacheco, et al. -- Interspecies Uncertainty in Molecular Responses and Toxicity of Mixtures / Moiz M. Mumtaz and Hana R. Pohl -- Recent Trends in Statistical QSAR Modeling of Environmental Chemical Toxicity / Alexander Tropsha -- Chirality and Its Role in Environmental Toxicology / Imran Ali, Hassan Y. Aboul-Enein, Mohd Marsin Sanagi and Wan Aini Wan Ibrahim -- Genetic Variability in Molecular Responses to Chemical Exposure / Chirag J. Patel and Mark R. Cullen -- Biomarkers in Toxicology and Risk Assessment / Bruce A. Fowler -- A Personalized Life: Biomarker Monitoring from Cradle to Grave / Harald Jungnickel and Andreas Luch -- On the Role of Low-Dose Effects and Epigenetics in Toxicology / Lena Smirnova, Alexandra Sittka and Andreas Luch -- Hormesis: Improving Predictions in the Low-Dose Zone / E. J. Calabrese.
  • Digital
    H. Singh and R. Grosschedl (ed.).
    Digital : Springer2005
    Print2005
    Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation / K.L. Medina, H. Singh -- Helix-loop-helix proteins in lymphocyte lineage determination / B.L. Kee -- Ikaros-family proteins : in search of molecular functions during lymphocyte development / B.S. Cobb, S.T. Smale -- Biochemistry of V(D)J recombination / D.G. Schatz, E. Spanopoulou -- The pre-B cell receptor in B cell development : recent advances, persistent questions and conserved mechanisms / M.R. Clark ... [et al.] -- Transcriptional control of B cell activation / L.M. Corcoran -- Expression of MHC II genes / G. Drozina ... [et al.] -- Class switch recombination : an emerging mechanism / A.L. Kenter -- Blimp-1 ; Immunoglobulin secretion and the switch to plasma cells / R. Schiammas, M.M. Davis -- Wnt signaling in lymphopoiesis / A. Timm, R. Grosschedl.
  • Print
    Kostandin Pajçini.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    Frank Curtis Brown.
    Digital2011
    Mannose 6-phosphate receptors (MPRs) deliver lysosomal acid hydrolases to the endosomal pathway and are then returned from late endosomes to the trans-Golgi network (TGN) for another round of transport. The long coiled-coil protein GCC185 tethers MPR-containing vesicles at the TGN. In the second chapter of this thesis, recent progress in the study of tethers in other laboratories is reviewed. The third chapter describes a mechanism by which GCC185 may tether MPR-containing vesicles. Distinct domains required for the two known functions of this protein, maintenance of Golgi structure and tethering MPR transport vesicles, were identified. The domain needed for vesicle tethering was shown to bind the clathrin adaptor AP-1. Moreover, data are presented showing the presence of AP-1 on transport vesicles en route to the Golgi complex. These data suggest that GCC185, which is localized to the TGN through Arl1- and Rab6-GTPase binding interactions at its C-terminus, engages incoming transport vesicles by binding AP-1 via an internal coiled-coil domain near central, putative "hinge" regions of the protein. Work presented in the fourth chapter describes progress toward understanding the Golgi fragmentation phenotype of cells depleted of GCC185. In addition to the C-terminal localization domain, an N-terminal domain required for Golgi structure maintenance was identified. In addition, GCC185 binding sites for numerous Golgi-localized Rab GTPases were identified, suggesting a model in which GCC185 can make lateral connections across the Golgi ribbon in order to maintain Golgi structure or promote a fused state in the equilibrium between membrane fusion and fission characteristic of the Golgi complex.
  • Digital
    editor, Gustav K. von Schulthess.
    Digital : Ovid2016
    "This brand new book discusses the most relevant technique or combination thereof for each disease and provides guidance on which modality to use -It is a disease oriented reference meant for interpreting integrated imaging studies. While it focuses on PET-CT and SPECT-CT, it also integrates PET-MR were applicable. Features: Allows clinical hybrid imaging users to compare modalities and decide whether to use PET/CT, PET/MR or SPECT/CT to solve a clinical question. Focus on clinical applications sans technological & radiopharmaceutical details. Inclusion of emerging field of PET/MR. New PART III on workflow and normal scans with various clinical tracers. Only book that incorporates PET/MR in a systematic way"--Provided by publisher.
  • Digital
    editor, Gustav K. von Schulthess ; CD-ROM editor, Daniel T. Schmid.
    Digital : Ovid2007
    Print2007
  • Digital
    edited by Danny R. Welch and Paul B. Fisher.
    Digital : ScienceDirect2016
    Chapter One: Detecting Tumor Metastases: The Road to Therapy Starts Here -- 1. Introduction -- 2. Preclinical In Vitro and In Vivo Models of Metastasis -- 2.1. In Vitro Models -- 2.2. In Vivo Models -- 3. Approaches Currently Used to Detect Metastatic Lesions (on a Preclinical Level) -- 3.1. Lab Tests/Histopathology -- 3.2. Noninvasive Blood Tests -- 3.3. Small Animal Imaging -- 3.4. Molecular-Genetic Imaging (Promoter-Based Protocols) -- 3.5. Circulating Tumor Cells -- 4. Approaches Used to Detect Metastatic Lesions (on a Clinical Level) -- 4.1. Biomarkers for Metastasis -- 4.2. Imaging Procedures -- 4.3. Circulating Tumor Cells -- 5. Metastasis Detection/Therapy: Combining Imaging with Therapy (Theranostics) -- 6. Challenges Faced in Detecting Metastatic Cells -- 7. Conclusions and Future Directions -- Acknowledgments -- References -- Chapter Two: The Relationship Between Dormant Cancer Cells and Their Microenvironment -- 1. Introduction -- 2. Models to Study Tumor Cell Dormancy -- 3. Intrinsic and Extrinsic Signals Converge to Induce Tumor Cell Dormancy -- 4. Cooperative Extrinsic Signals Induce Dormancy Within the Bone Microenvironment -- 5. Endosteal and Perivascular Niches Support Cancer Cell Dormancy -- 6. Reactivation from Dormancy -- 7. The Immune System and Dormancy -- 8. Summary and Outlook -- References -- Chapter Three: Defining the Influence of Germline Variation on Metastasis Using Systems Genetics Approaches -- 1. Introduction -- 2. Hereditary Factors Associated with Cancer Aggressiveness and Metastasis in Human Populations -- 2.1. Epidemiological Analysis -- 2.2. Genetic Analysis Human Cohorts -- 3. Systems Genetics Approaches to Identify Hereditary Modifiers of Metastasis -- 3.1. Breast Cancer -- 3.2. Prostate Cancer -- 3.3. Melanoma -- 4. Conclusions -- Acknowledgments -- References -- Chapter Four: Breast Cancer Metastasis Suppressor 1 (BRMS1): Robust Biological and Pathological Data, But Still Enigmatic ... -- Concluding Thoughts -- Acknowledgments -- References -- Chapter Five: Immune Regulation of the Metastatic Process: Implications for Therapy -- 1. Introduction -- 2. Key Players -- 2.1. Monocytes -- 2.2. Macrophages -- 2.3. Neutrophils -- 2.4. T Lymphocytes -- 2.5. Natural Killer Cells -- 3. Invasion and Intravasation -- 3.1. Macrophages -- 3.2. Neutrophils -- 3.3. T Lymphocytes -- 4. Survival and Extravasation -- 4.1. Monocytes -- 4.2. Neutrophils -- 4.3. T Lymphocytes -- 4.4. NK Cells -- 5. Ectopic Growth -- 5.1. Macrophages -- 5.2. Neutrophils -- 5.3. T Lymphocytes -- 5.4. NK Cells -- 6. Therapeutic Implications -- Acknowledgments -- References -- Chapter Six: MicroRNA and Metastasis -- 1. MicroRNAs -- 1.1. Noncoding RNAs and the Discovery of MicroRNAs -- 1.2. miRNA Biogenesis and Mechanisms of Action -- 1.3. miRNA Functions -- 2. miRNAs in Cancer ...
  • Digital
    Jeannine Yon-Kahn, Guy Herve.
    Digital : Springer2010
  • Digital
    Falk Nimmerjahn, editor.
    Digital : Springer2014
    This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • Digital
    Soren Joseph Peterson.
    Digital2011
    From a structural standpoint, one of the most characteristic general design elements of the mammalian organism is its tubular nature. The lung and circulatory system shuttle oxygen and nutrients to target tissues and allow for the excretion of waste products. In some ways, the vasculature lies at the center of human physiology--its passageways provide the infrastructure for maintaining homeostasis. Despite the importance of tubular networks in human health and disease, we have a poor understanding of many aspects of the genetic, molecular, and cellular programs controlling the development of these complex structures. The Drosophila melanogaster tracheal system, an elaborate network of hollow epithelial tubes, transports gases to and from target tissues. The tracheal system, with its simple structure, tractable genetics, and substantial experimental toolkit has emerged as an excellent model system for studying questions with relevance to more complex tubular systems. During development, tracheal branches ramify on the surface of target tissues, providing oxygen to every cell in the body. However, in a phenomenon unique to the Drosophila flight muscle, trachea are also present within plasma membrane invaginations deep below the muscle's outer extremities and have been described to surround every mitochondria of the flight muscle, thus coupling oxygen delivery directly to aerobic respiration at the mitochondrion. Although the presence of trachea within flight muscle membrane invaginations has been described for over 150 years, the developmental progression and cellular and molecular basis of this subcellular targeting process is unknown. In Chapter 2, we show that tracheal branches invade the developing flight muscle Transverse (T)-tubule plasma membrane invagination system during a brief period of pupal development. Branchless (Bnl) FGF, a fibroblast growth factor that functions as a chemoattractant, is required in the flight muscle, and its cognate receptor, Breathless (Btl) FGFR, is required in trachea for the tracheal invasion process to occur. Whereas Bnl FGF is localized to all flight muscle plasma membranes prior to tracheal invasion, during invasion Bnl FGF localizes preferentially to the T-tubule and is excluded from the surrounding plasma membrane. In addition to Bnl FGF, core polarity regulators commonly found on basolateral membranes in epithelial cells also preferentially localize to the T-tubule network during tracheal invasion. We find that depletion of AP-1[gamma], targeting machinery required for basolateral secretion in Drosophila epithelia, can also reroute Bnl FGF secretion to the outer plasma membrane and away from T-tubule openings, shifting trachea to the plasma membrane and away from T-tubules. We propose that (1) polarized secretion of Bnl FGF to the T-tubule guides tracheal branches into the T-tubule network and that (2) polarized Bnl FGF secretion is established via the redeployment of ancestral basolateral secretion pathways to the T-tubules, a membrane domain having molecular signatures of epithelial basolateral domains. To our knowledge, compartmentalized secretion of Bnl FGF to flight muscle T-tubule membranes is the first example of polarized subcellular secretion of a growth factor with functional consequences for the development of another tissue. In Chapter 3, we examine the molecular machinery involved in maintaining the polarized secretion of Bnl FGF during tracheal invasion. We find a host of secretory machinery, including several Rabs, Myosin V, an actin nucleator, and others, to be involved in the secretion of Bnl-FGF to the T-tubule during tracheal invasion. From these data we propose a molecular model to explain polarized Bnl FGF secretion at the T-tubule. Why is the flight muscle the only tissue invaded by trachea? In Chapter 4, we find that the flight muscle is structurally adapted to allow its T-tubule plasma membrane invagination network to be co-opted by migrating tracheal processes. In contrast to other muscles, the flight muscle T-tubule network forms large holes on the muscle surface as part of its development. The tracheal invasion process in the flight muscle is therefore the consequence not only of a polarized secretion process as discussed in Chapter 2, but also a structurally distinct stage of flight muscle development. In the final chapter, we search for the fine tracheal tubes reported to target and form contacts on the flight muscle mitochondria. We find an extracellular protein-based lattice of the appropriate diameter and localization to potentially represent the reported tracheal extensions to the mitochondria and propose several models of protein lattice formation. We hope that insight derived from this work spurs future investigators in a host of areas. The exquisite example of targeting to specific membrane domains dependent on a subcellular chemoattractant gradient demonstrated by the invading tracheal branch may provide insight into a number of developmental scenarios where fine targeting of different cells is required. We also hope that our finding regarding polarized secretion in muscle inspires new ways to think about the assembly of muscle membranes during development and disease states.
  • Digital
    edited by Michel M.J. Modo, Jeff W.M. Bulte.
    Digital : CRCnetBASE2007
    Methods for labeling non-phagocytic cells with MR contrast agents / Joseph A. Frank, Stasia A. Anderson, & Ali S. Arbab -- Cellular imaging of cell transplants / Michel Modo & Jeff W.M. Bulte -- Cellular and molecular imaging of the diabetic pancreas / Zdravka Medarova & Anna Moore -- Functional cellular imaging with manganese / Vincent van Meir & Annemie van der Linden -- Translating promising experimental approaches to clinical trials / Adrian D. Nunn -- An outlook on cellular and molecular MR imaging / Michel Modo & Jeff W.M. Bulte. What is molecular and cellular imaging? / Michel Modo & Jeff W.M. Bulte -- The physicochemical principles of MR contrast agents / Peter Caravan -- Paramagnetic contract agents / Silvio Aime ... [et al.] -- Superparamagnetic contrast agents / Claire Corot ... [et al.] -- Physical mechanism and applications of cest contrast agents / Mike McMahon ... [et al.] -- Paracest contrast agents / A. Dean Sherry & Mark Woods -- Genetic approaches for modulating MRI contrast / Eric Ahrens, Williams F. Goins, Clinton S. Robinson -- Molecular and functional mr imaging of cancer / Michael A. Jacobs ... [et al.] -- Molecular imaging of atherosclerosis with magnetic resonance / Karen C. Briley-Saebo ... [et al.] -- Molecular imaging of apoptosis / Mikko Kettunen & Kevin M. Brindle -- Molecular imaging of reporter genes / Keren Ziv ... [et al.] -- Pharmacological MRI as a molecular imaging technique / Y. Iris Chen & Bruce Jenkins -- Cellular imaging of the liver using contrast agents / N. Cem Balci & Sukru Mehmet Erturk -- Cellular imaging of macrophage activity in infection and inflammation / Martin Rausch ... [et al.] -- Cellular imaging of macrophage activity in stroke / Ralph Weber & Mathias Hoehn -- Magnetic resonance imaging in developmental biology / Cyrus Papan, J. Michael Tyszka, Russell E. Jacobs --
  • Digital
    edited by Nicholas Boulis, Deirdre O'Connor, and Anthony Donsante.
    Digital : ScienceDirect2017
    1. Molecular and extracellular cues in motor neuron specification and differentiation / R.L. Swetenburg, S.L. Stice and L. Karumbaiah -- 2. Natural history of amyotrophic lateral sclerosis / M.J. Magnussen and J.D. Glass -- 3. Genetics of amyotrophic lateral sclerosis / K.P. Kenna, J.E. Landers and N. Ticozzi -- 4. Molecular mechanisms of amytrophic lateral sclerosis / M. Collins and R. Bowser -- 5. An introduction to natural history, genetic mapping, and clinical spectrum of spinal muscular atrophy / A. McDonough, L. Urquia and N. Boulis -- 6. Genetics of spinal muscular atrophy / A.H.M. Burghes and V.L. McGovern -- 7. Introduction to gene and stem-cell therapy / D.M. O'Connor -- 8. Gene therapy for amytrophic lateral sclerosis / A. Dosante -- 9. Stem cell therapy for amytrophic lateral sclerosis / K.S. Chen and E.L. Feldman -- 10. Gene therapy for spinal muscular atrophy / M.R. Miller, E.Y. Osman and C.L. Lorson -- 11. Cellular therapy for spinal muscular atrophy / I. Faravelli and S. Corti -- 12. Clinical trials to date / B.J. Mader and N. Boulis.
  • Digital
    Jim J. Hagan, editor.
    Digital : Springer2011
    Preface -- Mouse mutagenesis and disease models for Neuropsychiatric disorders. -- Drosophila as a model organism for the study of neuropsychiatric disorders -- Transgenic animal models of Huntington{u2019}s Disease -- Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges -- Animal Models of Depression: Molecular Perspectives.-Animal models of ADHD -- Mouse Models of Autism: Testing Hypotheses about Molecular Mechanisms -- Advances in animal models of drug addiction -- When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience -- Functional and Pharmacological MRI in understanding brain function at a systems level -- The pig as model animal for studying cognition and neurobehavioral disorders.
  • Digital
    Thomas H. Schindler, Richard T. George, Joao A.C. Lima, editors.
    Digital : Springer2015
    This book provides the most up-to-date coverage of the combined use of imaging modalities in order to acquire important functional and morphological information on cardiovascular disease and enhance disease detection. The recent developments in PET/MRI, cardiac CT, PET/CT, and SPECT/CT and their impact on clinical practice are explained, and special attention is also devoted to imaging parameters and protocols for use in practice and research. The utility of multimodality imaging techniques for diagnosis and evaluation is discussed in the context of various clinical scenarios, including ischemic cardiomyopathy, myocarditis, myocardial fibrosis, cardiac sarcoidosis, and atherosclerotic plaque disease. Written by renowned researchers and clinicians, the book is an ideal concise reference on today's most advanced imaging techniques. It will appeal to all clinicians, trainees, and technicians who are involved in the diagnosis and risk assessment of cardiovascular disease.
  • Digital
    Keith A. Foster, editor.
    Digital : Springer2014
    Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins, and is both up to date and authoritative.
  • Digital
    Michał Witt, Małgorzata Dawidowska, Tomasz Szczepánski, editors.
    Digital : Springer2012
    Part 1. Molecular Biology of Selected Hemato-oncologic Diseases -- Molecular Biology of Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich and Tomasz Szczepański -- Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia / Agata A. Filip, Marta Libura, Sebastian Giebel and Olga Haus -- Molecular Pathogenesis of Aggressive B-cell Lymphomas / Przemysław Juszczyński and Krzysztof Warzocha -- Molecular Biology and Classification of Multiple Myeloma / Anna Dmoszyńska and Norbert Grząśko -- Chronic Lymphocytic Leukemia / Anton W. Langerak and Yorick Sandberg -- Molecular Biology of Chronic Myeloid Leukemia / Tomasz Sacha, Kajetana Foryciarz and Aleksander B. Skotnicki -- Molecular Biology of Myelodysplastic Syndromes / Francesc Solé -- Myeloproliferative Neoplasms / Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner and Aleksandra Leszczyńska -- Part 2. Diagnostics and Monitoring of Therapy of Hemato-oncologic Deseases -- Flow Cytometric Immunophenotyping as Diagnostic Tool of Hematopoietic Malignancies / Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena and Julia Almeida, et al. -- Cytogenetics in Hematology / Olga Haus, Anna Poluha and Katarzyna Skonieczka -- Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Tomasz Szczepański, Małgorzata Dawidowska and Katarzyna Derwich -- Gene Expression Profiling in Hematologic Malignancies / Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak and Krzysztof Warzocha -- Part 3. Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation -- Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Wachowiak -- Genetic Basis of Donor-Recipient Matching in Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Nowak and Jacek Wachowiak -- Chimerism Following Allogeneic Transplantation of Hematopoietic Stem Cells / Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak and Michał Witt -- Peritransplantation Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Katarzyna Derwich and Tomasz Szczepański -- Biobanks of Cellular Material / Wiesław Wiktor-Jędrzejczak and Elżbieta Urbanowska -- Part 4. Molecular Diagnostic Protocols -- Biobanking of Cellular Material / Anna Poluha and Elżbieta Urbanowska -- Isolation of Mononuclear Cells from Human Blood and Bone Marrow by Density Gradient Centrifugation / Małgorzata Dawidowska -- Molecular Techniques Commonly Used in Hemato-oncology / Monika D. Kraszewska and Ewa Ziętkiewicz -- Genetic Methods of HLA Typing / Jacek Nowak, Renata Mika-Witkowska and Elżbieta Graczyk-Pol -- Post-Transplant Chimerism Analysis Through STR-PCR and RQ-PCR / Małgorzata Dawidowska, Katarzyna Guz, Agnieszka Orzińska, Justyna Smolarczyk-Wodzyńska and Monika D. Kraszewska, et al. -- Analysis of Minimal Residual Disease with the Use of Rearrangements of Ig/TCR Genes Through RQ-PCR / Małgorzata Dawidowska, Vincent H. J. van der Velden, Michał Witt and Tomasz Szczepański -- Molecular Diagnostics of Acute Myeloblastic Leukemia / Marta Libura, Agata A. Filip and Olga Haus -- Assessment of the Presence and the Level of BCR-ABL Fusion Gene Expression and Mutational Status in ABL Kinase Domain / Sylwia Czekalska, Magdalena Zawada and Izabela Florek -- Studies of Rearrangements and Somatic Hypermutation of IGHV Genes in Chronic Lymphocytic Leukemia / Anton W. Langerak, Richard Rosenquist, Paolo Ghia, Chrysoula Belessi and Kostas Stamatopoulos, et al. -- Molecular Biology Methods in the Diagnosis of Multiple Myeloma / Anna Dmoszyńska and Sylwia Chocholska -- Molecular Methods in Myeloproliferative Neoplasms / Aleksandra Leszczyńska, Witold Prejzner, Maria Bieniaszewska and Andrzej Hellmann -- Informed Consent for Participation in Research Project / Małgorzata Dawidowska and Michał Witt.
  • Digital
    edited by Peter Csermely, László Vígh.
    Digital : Springer2007
    Print2007
    Protein misassembly: macromolecular crowding and molecular chaperones / R. John Ellis -- The cellular "networking" of mammalian HSP27 and its functions in the control of protein folding, redox state and apoptosis / André-Patrick Arrigo -- Molecular interaction network of the HSP90 chaperone system / Rongmin Zhao and Walid A. Houry -- Organization of the functions and components of the endoplasmic reticulum / Yuichiro Shimizu and Linda M. Hendershot -- Molecular crime and cellular punishment: active detoxification of misfolded and aggregated proteins in the cell by the chaperone and protease networks / Marie-Pierre Hinault and Pierre Goloubinoff -- Chaperones as parts of cellular networks / Peter Csermely, Csaba Söti and Gregory L. Blatch -- Chaperones as parts of organelle networks / György Szabadkai and Rosario Rizzuto -- Heat shock factor 1 as a coordinator of stress and developmental pathways / Julius Anckar and Lea Sistonen -- Chaperone regulation of the heat shock protein response / Richard Voellmy and Frank Boellmann -- Mechanisms of activation and regulation of the heat shock-sensitive signaling pathways / Sébastien Ian Nadeau and Jacques Landry -- Membrane-regulated stress response: a theoretical and practical approach / László Vígh ... [et al.] -- Beyond the lipid hypothesis: mechanisms underlying phenotypic plasticity in inducible cold tolerance / Scott A.L. Hayward ... [et al.] -- Trehalose as a "chemical chaperone:" fact and fantasy / John H. Crowe -- Chaperones as part of immune networks / Zoltán Prohászka -- The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging / Heather R. Brignull, James F. Morley and Richard I. Morimoto -- HSP90 and developmental networks / Suzannah Rutherford, Jennifer R. Knapp and Peter Csermely.
  • Digital
    edited by Moncef Zouali.
    Digital : Springer2005
    Print2005
  • Digital
    editor, Rafael Rosell.
    Digital : Future Med2012
    Integrating molecular knowledge in clinical decision-making for personalized cancer management -- Gastrointestinal stromal tumors -- Metastatic melanoma -- Ovarian cancer -- Triple-negative breast cancer -- Gastric cancer -- Pleural mesothelioma -- Lung adenocarcinoma.
  • Print
    Tovi Marit Anderson.
    Print2009
    Status: Not Checked OutLane Catalog Record
  • Digital
    Dirk P. Dittmer, Susan E. Krown, editors.
    Digital : Springer2010
    Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well. Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.
  • Digital
    [edited by] John Mendelsohn, Joe W. Gray, Peter M. Howley, Mark A. Israel, Craig B. Thompson.
    Digital : ClinicalKey2015
    Cancer : a genetic disorder / William C. Hahn, Robert A. Weinberg -- Oncogenes and signal transduction / Luca Grumolato, Stuart A. Aaronson -- Tumor suppressor genes / Nelson E. Brown, Philip W. Hinds -- DNA repair pathways and human cancer / Alan D. D'Andrea -- Epigenetics and cancer / Stephen B. Baylin -- Infectious agents and cancer / Peter M. Howley -- Environmental carcinogenesis / Erika L. Abel, John DiGiovanni -- Animal models : flies, fish, and yeast / Elspeth Payne, A. Thomas Look -- Genetic mouse models of cancer / Monte M. Winslow, Tyler Jacks -- Cancer stem cells and the microenvironment / Hasan Korkaya, April Davis, Max S. Wicha -- Regulation of the cell cycle / Yan Li, Olena Barbash, J. Alan Diehl -- Cell growth / David A. Guertin, David M. Sabatini -- Metabolism of cell growth and proliferation / Lydia W.S. Finley, Craig B. Thompson -- Apoptosis, necrosis, and autophagy / Eileen White, Douglas R. Green, Anthony G. Letai -- Cellular senescence / Jessica E. Bolden, Scott W. Lowe -- Role of the microenvironment in tumor initiation, progression, and metastasis / Cyrus M. Ghajar, Ana Luísa Correia, Mina J. Bissell -- Tumor angiogenesis / Brian Keith, M. Celeste Simon -- Invasion and metastasis / Swarnali Acharyya, Lynn Matrisian, Danny R. Welch, Joan Massagué -- Inflammation and cancer / Daniela F. Quail, Johanna A. Joyce -- Cancer systems biology : the future / Andrea Califano -- Biomarkers for assessing risk of cancer / Xifeng Wu, Jian Gu -- Protein biomarkers for detecting cancer : molecular screening / Susan Fisher, H. Ewa Witkowska -- Technology of analyzing nucleic acids in Cancer / Elaine R. Mardis -- Understanding and using information about cancer genomes / Paul T. Spellman, Josh Stuart, Joe W. Gray -- High-content analysis with cellular and tissue systems biology : a bridge between cancer cell biology and tissue-based diagnostics / Albert Gough, Timothy Lezon, James R. Faeder, Chakra Chennubhotla, Robert F. Murphy, Rebecca Critchley-Thorne, D. Lansing Taylor -- Molecular genetics of acute lymphoblastic leukemia / Eric S. Schafer, Judith Margolin, David G. Poplack, Karen R. Rabin -- Molecular biology of childhood neoplasms / David Malkin -- Biology of adult myelocytic leukemia and myelodysplasia / Sean M. Post, Hagop Kantarjian, Alfonso Quintás-Cardama -- Lymphoma / Owen A. O'Connor, Jennifer Amengual, Changchun Deng, Ahmed Sawas, Bachir Alobeid, Daniela Hoehn, Govind Bhagat -- Multiple myeloma / Giovanni Tonon, Kenneth C. Anderson -- Molecular mechanisms of esophageal cancer / Mario D. Terán, Ronan Kelly, Malcolm V. Brock -- Molecular basis of lung cancer / Jill E. Larsen, Ramaswamy Govindan, John D. Minna -- Molecular pathogenesis of head and neck cancer / Matthew L. Hedberg, Jennifer R. Grandis -- Colon and rectal cancer / Eric R. Fearon -- Molecular pathogenesis of pancreatic adenocarcinoma / Rachna T. Shroff, James L. Abbruzzese -- Molecular biology of breast cancer / Adrian V. Lee, Steffi Oesterreich, Nancy E. Davidson -- Molecular pathogenesis of ovarian cancer / Robert C. Bast Jr., Ignacio Romero, Gordon B. Mills -- Molecular basis of prostate cancer / Long-Cheng Li, Andrew C. Hsieh, Davide Ruggero, Kirsten L. Greene, Peter R. Carroll -- Molecular abnormalities in kidney cancer / Sabina Signoretti, Toni K. Choueiri, William G. Kaelin Jr. -- Biology of primary brain tumors / Matthew C. Havrda, Mark A. Israel -- Epithelial skin cancer / Adam B. Glick, Stuart H. Yuspa -- Molecular basis for treating cutaneous molecular / Marc S. Ernstoff -- Thyroid cancer / Steven I. Sherman -- Soft tissue sarcomas / Julie D.R. Reimann, Christopher D.M. Fletcher -- From bench to bedside with targeted therapies / John Mendelsohn -- Cancer therapeutics / William N. Hait, Eric Rubin, Joseph R. Bertino -- Natural and acquired resistance to cancer therapies / Branimir I. Sikic -- Phase I trials today / Daniel Morgensztern, Patricia M. LoRusso, Scott A. Boerner, Roy S. Herbst, Joseph Paul Eder -- Pharmacogenomics / Peter H. O'Donnell, Mark J. Ratain -- Monoclonal antibodies for the treatment of cancer / Louis M. Weiner, Rishi Surana -- Cancer and the cellular immune response / Patrick Hwu, Gregory Lizée, Yong-Jun Liu -- Cancer immunotherapy with vaccines and checkpoint blockade / Drew Pardoll -- Interferons / Ernest C. Borden -- Gene therapy and oncolytic viruses / Tanja Meyer Tamguney, W. Michael Korn, Frank McCormick -- RNA as a therapeutic molecule / George Adrian Calin, Carlo Maria Croce -- Heat shock protein 90 and the proteasome : housekeeping proteins that are also molecular targets for cancer therapy / Len Neckers, Mehdi Mollapour -- Hematopoietic growth factors and cytokines / Suhendan Ekmekcioglu, Razelle Kurzrock, Elizabeth A. Grimm -- Cancer chemoprevention / Scott M. Lippman, J. Jack Lee -- Molecular pathology / Christopher L. Corless.
  • Print
    [edited by] John Mendelsohn ... [et al.].
    Print2008
    Status: Not Checked OutLane Catalog Record
  • Digital
    Undurti N. Das.
    Digital : Springer2011
    The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
  • Digital
    Amittha Wickrema, Barbara Kee, editors.
    Digital : Springer2009
  • Digital
    Roland Martin, Andreas Lutterotti (eds.).
    Digital : Springer2010
    Print2010
  • Digital
    edited by Francis X. McCormack, Ralph J. Panos, Bruce C. Trapnell.
    Digital : Springer2010
    Clinical approach to rare lung diseases -- Clinical trials for rare lung diseases -- Idiopathic and familial pulmonary arterial hypertension -- Lymphangioleiomyomatosis -- Autoimmune pulmonary alveolar proteinosis -- Mutations in surfactant protein C and interstitial lung disease -- Hereditary haemorrhagic telangiectasia -- Hermansky-Pudlak Syndrome -- Alpha-1 antitrypsin deficiency -- Marfan syndrome -- Surfactant deficiency disorders: SP-B and ABCA3 -- Pulmonary capillary hemangiomatosis -- Anti-glomerular basement disease: Goodpasture's Syndrome -- Primary ciliary dyskinesia -- Pulmonary alveolar microlithiasis -- Cystic fibrosis -- Pulmonary Langerhans' cell histiocytosis: advances in the understanding of a true dendritic cell lung disease -- Sarcoidosis -- Scleroderma lung disease.
  • Digital
    Carmen Dolores Cordova.
    Digital2010
    The gamma-proteobacterium Shewanella oneidensis MR-1 utilizes a complex electron transfer network composed primarily of c-type cytochromes as well as iron-sulfur proteins, molybdoenzymes, and flavins, to respire under anoxic conditions a variety of compounds, including fumarate, nitrate, and dimethylsulfoxide (DMSO) in addition to Fe (III) and Mn (IV) minerals. Central to several respiratory pathways in this dissimilatory metal reducing bacterium (DMRB), including the electron transfer pathway to Fe (III), is CymA, a cytoplasmic membrane-bound tetraheme c-type cytochrome that functions as the major hydroquinone dehydrogenase and couples electron transport to various periplasmic oxidoreductases. Using a genetic approach involving the reconstruction of the putative electron transport chain of dissimilatory iron reduction from Shewanella oneidensis MR-1 in Escherichia coli, I showed that expression of cymA was necessary and sufficient to convert E. coli into a dissimilatory iron reducing (DIR) bacterium, indicating that CymA as a terminal reductase was the minimal electron transport chain within S. oneidensis MR-1 to Fe (III). In addition, we isolated and characterized a [delta]cymA suppressor mutant that was capable of respiration of fumarate, ferric citrate, and DMSO, but not of nitrate. The suppression was found to be due to insertion sequence-mediated transcriptional activation of mccCD, which encode for a putative periplasmic iron sulfur protein and an integral membrane hydroquinone dehydrogenase, respectively.
  • Digital
    Jörg Overmann (ed.).
    Digital : Springer2006
    Syntrophic associations in methanogenic degradation / B. Schink -- Symbiosis between non-related bacteria in phototropic consortia / J. Overmann -- Prokaryotic symbionts of termite gut flagellates : phylogenetic and metabolic implications of a tripartite symbiosis / A. Brune, U. Stingl -- Towards an understanding of the killer trait : Caedibacter endocytobionts in Paramecium / J. Kusch, H.-D. Görtz -- Bacterial ectosymbionts which confer motility : Mixotricha paradoxa from the intestine of the Australian termite Mastotermes darwiniensis / Helmut König ... [et al.] -- Extrusive bacterial ectosymbionts of ciliates / G. Rosati -- Hydrogenosomes and symbiosis / J.H.P. Hackstein, N. Yarlett -- Molecular interactions between Rhizobium and legumes / P. Skorpil, W.J. Broughton -- Molecular mechanisms in the nitrogen-fixing Nostoc-bryophyte symbiosis / J.C. Meeks -- Symbiosis of thioautotrophic bacteria with Riftia pachyptila / F.J. Stewart, C.M. Cavanaugh -- Symbioses of methanotrophs and deep-sea mussels (Mytilidae: Bathymodiolinae) / E.G. DeChaine, C.M. Cavanaugh -- Symbioses between bacteria and gutless marine oligocahetes / N. Dubilier, A. Blazejak, C. Rühland -- Roles of bacterial regulators in the symbiosis between Vibrio fischeri and Euprymna scalopes / K. Geszvain, K. Visick -- Molecular requirements for the colonization of Hirudo medicinalis by Aeromonas veronii / J. Graf.
  • Digital
    edited by Andreas Marx and Oliver Seitz.
    Digital : Springer Protocols2008
    Basic principles of fluorescence and energy transfer / Larry E. Morrison -- Multiplex detection of mutations / David S. Perlin, Sergey Balashov, and Steven Park -- Detection of salmonella species in foodstuffs / Arvind A. Bhagwat ... [et al.] -- Identification of homozygous transgenic mice by genomic real-time PCR / Gunter Schmidtke and Marcus Groettrup -- Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR greenI-based assay : determining FAT10 mRNA levels in hepatocellular carcinoma / Sebastian Lukasiak ... [et al.] -- Absolute quantitation of feline leukemia virus proviral DNA and viral RNA loads by TaqMan real-time PCR and RT-PCR / Valentino Cattori and Regina Hofmann-Lehmann -- High-throughput real-time PCR / Thomas D. Schmittgen, Eun Joo Lee, and Jinmai Jiang -- Design and use of scorpions fluorescent signalling molecules / Rachael Carters ... [et al.] -- Hybridization probe pairs and single-labeled probes : an alternative approach for genotyping and quantification / Thomas Froehlich and Oliver Geulen -- EasyBeacons for the detection of methylation status of single CpG duplets / Ulf B. Christensen -- Quenched autoligation probes / Adam P. Silverman, Hiroshi Abe, and Eric T. Kool -- HyBeacon probes for rapid DNA sequence detection and allele discrimination / David J. French ... [et al.] -- FIT-probes in real-time PCR / Elke Socher and Oliver Seitz -- SNP genotyping by unlabeled probe melting analysis / Maria Erali, Robert Palais, and Carl Wittwer -- Molecular beacons for protein-DNA interaction studies / Jun Li ... [et al.] -- DNA polymerase profiling / D. Summerer -- Modular reporter hairpin ribozymes for analyzing molecular interactions / S. Hani Najafi-Shoushtari and Michael Famulok -- Screening of molecular interactions using reporter hammerhead ribozymes / Jörg S. Hartig and Michael Famulok.
  • Print
    George Feuer, Felix A. De la Iglesia.
    Status: Not Checked OutLane Catalog Record
  • Digital
    David P. Clark, Nanette J. Pazdernik.
    Digital : ClinicalKey2013
    Unit 1. Basic Chemical and Biological Principles -- Unit 2. The Genome -- Unit 3. The Central Dogma of Molecular Biology -- Unit 4. Regulating Gene Expression -- Unit 5. Subcellular Life Forms -- Unit 6. Changing the DNA Blueprint.
  • Print
    by H. E. Schultze and J. F. Heremans.
    Status: Not Checked OutLane Catalog Record
    v. 1. Nature and metabolism of extracellular proteins.
  • Digital
    Ahmad M. Khalil, Jeff Coller, editors.
    Digital : Springer2013
    Chromatin regulation by long non-coding RNAs / Daniel C. Factor, Paul J. Tesar and Ahmad M. Khalil -- Regulatikon of eukaryotic cell differentiation by long non-coding RNAs / Juan R. Alvarez-Dominguez, Wenqian Hu and Harvey F. Lodish -- Roles of long non-coding RNAs in X-chromsome inactivation / J. Mauro Calabrese and Terry Magnuson -- Roles of long non-coding RNAs in genomic imprinting / Kristen Martins-Taylor and Stormy J. Chamberlain -- Dysregulation of long non-coding RNAs in human disease / Nianwei Lin and Tariq M. Rana -- Functions of long non-coding RNAs in non-mamallian systems / Alex Tuck and David Tollervey -- Emerging technologies to study long non-coding RNAs / Fereshteh Jahaniani ... [et al.]
  • Digital
    Markus J. Tamás, Enrico Martinoia (eds.).
    Digital : Springer2006
  • Print
    Bruce Alberts, Alexander Johnson, Julian Lewis, David Morgan, Martin Raff, Keith Roberts, Peter Walter ; with problems by John Wilson, Tim Hunt.
    Print2015
    Status: Not Checked OutLane Catalog Record
    "As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens."-- Provided by publisher.
  • Print
    Bruce Alberts ... [et al.] ; with problems by John Wilson, Tim Hunt.
    Print2008
    Status: Not Checked OutLane Catalog Record
    Cells and genomes -- Cell chemistry and biosynthesis -- Proteins -- DNA, chromosomes, and genomes -- DNA replication, repair, and recombination -- How cells read the genome: from DNA to protein -- Control of gene expression -- Manipulating proteins, DNA, and RNA -- Visualizing cells -- Membrane structure -- Membrane transport of small molecules and the electrical properties of membranes -- Intracellular compartments and protein sorting -- Intracellular vesicular traffic -- Energy conversion: mitochondria and chloroplasts -- Mechanisms of cell communication -- The cytoskeleton -- The cell cycle -- Apoptosis -- Cell junctions, cell adhesion, and the extracellular matrix -- Cancer -- Sexual reproduction: meiosis, germ cells, and fertilization -- Development of multicellular organisms -- Specialized tissues, stem cells, and tissue renewal -- Pathogens, infection, and innate immunity -- The adaptive immune system. Tables: The genetic code, amino acids.
  • Digital
    Bruce Alberts ... [et al.].
    Digital : NCBI Bookshelf2002Fulltext accessible by its search box
    Print2002
    Print2002
  • Print
    Bruce Alberts ... [et al.] ; with problems by John Wilson ... [et al.].
    Print2008
    Status: Not Checked OutLane Catalog Record
  • Print
    James D. Watson, Tania A. Baker, Stephen P. Bell, Alexander Gann, Michael Levine, Richard Losick.
    Print2008
    Status: Not Checked OutLane Catalog Record
    The Mendelian view of the world -- Nucleic acids convey genetic information -- The importance of weak chemical interactions -- The importance of high-energy bonds -- Weak and strong bonds determine macromolecular structure -- The structures of DNA and RNA -- Genome structure, chromatin, and the nucleosome -- The replication of DNA -- The mutability and repair of DNA -- Homologous recombination at the molecular level -- Site-specific recombination and transposition of DNA -- Mechanisms of transcription -- RNA splicing -- Translation -- The genetic code -- Transcriptional regulation in prokaryotes -- Transcriptional regulation in eukaryotes -- Regulatory RNAs -- Gene regulation in development and evolution -- Genome analysis and systems biology -- Techniques of molecular biology -- Model organisms.
  • Digital
    Sunil K. Lal, editor.
    Digital : Springer2010
    The SARS outbreak in 2002 caused unprecedented devastation and exhibited unusually high rates of morbidity and mortality. For the SARS coronavirus, the transmission vehicle was man. What added to the spread was man's convenient, rapid and affordable ways of travel that caused the virus to spread globally in a short span of time. The SARS coronavirus jumped the species barrier, similar to many recent zoonotic diseases, avian flu, swine flu, Nipah and encephalitis virus. It is extremely important for us to understand the enemy before it strikes again in order to be able to combat such outbreaks as and when they occur. Molecular mechanisms that the virus exploits within its host and that result in infection and pathogenesis are the key to being able to block its transmission cycle. In this book, leading scientists from around the globe have discussed molecular aspects of viral entry, replication, viral gene expression, pathogenesis and host immune response against the SARS coronavirus.
  • Digital
    Nalini M. Rajamannan, editor.
    Digital : Springer2014
    This book presents the cellular details and the basic molecular biology approaches for understanding cardiac valvular disease. It provides novel cellular targets for developing future clinical trials and comprehensive clinical discussion of this expanding field. Molecular Biology of Valvular Heart Disease will guide physicians on the potential medical therapies to treat valvular heart disease while providing a platform for cellular targeting of valvular heart disease. Residents and fellows in cardiology, interventional cardiology, cardiac surgery, and current and future valve biologists alike will find this book to be an invaluable resource for developing further interest and understanding of the cellular basis for cardiac valvular disease treatment.

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