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  • Methods in cilia & flagella 2015
    Imaging centrosomes and cilia in the mouse kidney / Masato Hoshi, Jinzhi Wang, Sanjay Jain, Moe R. Mahjoub -- Ependymal cell differentiation, from monociliated to multiciliated cells / Nathalie Delgehyr, Alice Meunier, Marion Faucourt, Montserrat Bosch Grau, Laetitia Strehl, Carsten Janke, Nathalie Spassky -- Observing planar cell polarity in multiciliated mouse airway epithelial cells / Eszter K. Vladar, Yin Loon Lee, Tim Stearns, Jeffrey D. Axelrod -- Imaging and analyzing primary cilia in cardiac cells / Nicolas Diguet, Jean-Francois Le Garrec, Tommaso Lucchesi, Sigolene M. Meilhac -- Cilia in photoreceptors / Linjing Li, Manisha Anand, Kollu Nageswara Rao, Hemant Khanna -- Analysis of primary cilia in the developing mouse brain / Judith T.M.L. Paridaen, Wieland B. Huttner, Michaela Wilsch-Brauninger -- In vivo investigation of cilia structure and function using Xenopus / Eric R. Brooks, John B. Wallingford -- A quantitative approach to study endothelial cilia bending stiffness during blood flow mechanodetection in-vivo / Francesco Boselli, Jacky G. Goetz, Gilles Charvin, Julien Vermot -- Quantitative description of fluid flows produced by left-right cilia in zebrafish / Craig Fox, M. Lisa Manning, Jeffrey D. Amack -- Efficient live fluorescence imaging of intraflagellar transport in mammalian primary cilia / Hiroaki Ishikawa, Wallace F. Marshall -- Analysis of soluble protein entry into primary cilia using semipermeabilized cells / David K. Breslow, Maxence V. Nachury -- Methods for imaging individual cilia in living echinoid embryos / Robert L. Morris, Hans W. Pope, Adam N. Sholi, Leah M. Williams, Chelsea R. Ettinger, Gwendolyn M. Beacham, Tatsushi Shintaku, Zachary D. Abbott, Elyse M. Doherty -- The planarian Schmidtea mediterranea as a model for studying motile cilia and multiciliated cells / Cyril Basquin, Anne-Marie Orfila, Juliette Azimzadeh -- Quantitative analysis of flagellar proteins in Drosophila sperm tails / Teresa Mendes Maia, Perrine Paul-Gilloteaux, Renata Basto -- Imaging cilia in Drosophila melanogaster / Jennifer Vieillard, Jean-Luc Duteyrat, Elisabeth Cortier, Benedicte Durand -- Studying G protein-coupled receptors: Immunoblotting, immunoprecipitation, phosphorylation, surface labeling, and cross-linking protocols / Kasturi Pal, Hemant Badgandi, Saikat Mukhopadhyay -- Image analysis of Caenorhabditis elegans ciliary transition zone structure, ultrastructure, molecular composition and function / Anna A. W. M. Sanders, Julie Kennedy, Oliver E. Blacque -- Genetic and genomic approaches to identify genes involved in flagellar assembly in Chlamydomonas reinhardtii / Huawen Lin, Susan K. Dutcher -- Axonemal motility in Chlamydomonas / Ken-ichi Wakabayashi, Ritsu Kamiya -- Posttranscriptional control over rapid development and ciliogenesis in marsilea / Stephen M. Wolniak, Thomas C. Boothby, Corine M. van der Weele -- Total internal reflection fluorescence microscopy of intraflagellar transport in tetrahymena thermophila / Yu-Yang Jiang, Karl Lechtreck, Jacek Gaertig -- Ciliary heterogeneity within a single cell : the paramecium model / Anne Aubusson-Fleury, Jean Cohen, Michel Lemullois -- Imaging intraflagellar transport in trypanosomes / Julien Santi-Rocca, Nicolas Chenouard, Cécile Fort, Thibault Lagache, Jean-Christophe Olivo-Marin, Philippe Bastin -- Scanning and three-dimensional electron microscopy methods for the study of trypanosoma brucei and leishmania mexicana flagella / Eva Gluenz, Richard John Wheeler, Louise Hughes, Sue Vaughan.
  • Print Material
    v. 1. Laboratory methods, pts. A-C -- v. 2. Clinical methods.
  • Methods in enzymology v. 1-, 1955-
  • Print Material
    v. 1. Chemical determinations -- v. 2. Bioassay -- v. 3. & 4. Steroidal activity in experimental animals and man, Part A & B.
  • Methods in membrane lipids 2007
    Springer Protocols
  • 1. Techniques for cultivating methanogens / Ralph S. Wolfe -- 2. Genetic methods for methanosarcina species / Nicole Buan, Gargi Kulkarni, and William Metcalf -- 3. Genetic systems for hydrogenotrophic methanogens / Felipe Sarmiento B., John A. Leigh, and William B. Whitman -- 4. Molecular tools for investigating ANME community structure and function / Steven J. Hallam ... [et al.] -- 5. Studying gene regulation in methanogenic archaea / Michael Rother, Christian Sattler, and Tilmann Stock -- 6. Growth of methanogens under defined hydrogen conditions / John A. Leigh -- 7. Preparation of [Fe]-hydrogenase from methanogenic archaea / Seigo Shima, Michael Schick, and Haruka Tamura -- 8. Assay of methylotrophic methyltransferases from methanogenic archaea / Donald J. Ferguson, David G. Longstaff, and Joseph A. Krzycki -- 9. Methyl-coenzyme M reductase from methanothermobacter marburgensis / Evert C. Duin, Divya Prakash, and Charlene Brungess -- 10. Methods for analysis of acetyl-CoA synthase : applications to bacterial and archaeal systems / David A. Grahame -- 11. Acetate kinase and phosphotransacetylase / James G. Ferry -- 12. Sodium ion translocation and ATP synthesis in methanogens / Katharina Schlegel and Volker Müller -- 13. Proton translocation in methanogens / Cornelia Welte and Uwe Deppenmeier -- 14. Measuring isotope fractionation by autotrophic microorganisms and enzymes / Kathleen M. Scott, Gordon Fox, and Peter R. Girguis -- 15. 2-oxoacid metabolism in methanogenic CoM and CoB biosynthesis / David E. Graham -- 16. Biomethanation and its potential / Irini Angelidaki ... [et al.].
  • A comprehensive analysis of the effect of microarray data preprocessing methods on differentially expressed transcript selection -- Differentiation detection in microarray normalization -- Preprocessing and normalization for Affymetrix GeneChip expression microarrays -- Spatial detrending and normalization methods for two-channel DNA and protein microarray data -- A survey of cDNA microarray normalization and a comparison by k-NN classification -- Technical variation in modeling the joint expression of several genes -- Biological interpretation for microarray normalization selection -- Methodology of functional analysis for omics data normalization -- Exon array analysis for the detection of alternative splicing -- Normalization of array CGH data -- SNP array-based analysis for the detection of chromosomal aberrations and copy number variations.
  • The three-dimensional structure of proteins. -- Liquid chromatography of biomolecules. -- Mass spectrometry. -- X-ray structural analysis. -- Protein infrared spectroscopy. -- Electron microscopy. -- Scanning probe microscopy. -- Biophysical nanotechnology. -- Proteomics: high throughput protein functional analysis. -- Ion mobility spectrometry. -- Ø-value analysis. -- Evolutionary computer programming. -- Conclusions.
  • Methods in molecular biology (Humana Press) v. 1-, 1984-
    Springer Protocols
  • Methods in molecular medicine v. 1-, 1996-
    Springer Protocols
  • Methods in protein design 2013
    Computational design of novel protein binders and experimental affinity maturation -- Mining tertiary structural motifs for assessment of designability -- Computational methods for controlling binding specificity -- Flexible backbone sampling methods to model and design protein alternative conformations -- Osprey: protein design with ensembles, flexibility, and provable algorithms -- Scientific benchmarks for guiding macromolecular energy function improvement -- Molecular dynamics simulations for the ranking, evaluation, and refinement of computationally designed proteins -- Multistate protein design using CLEVER and CLASSY -- Using analyses of amino acid coevolution to understand protein structure and function -- Evolution-based design of proteins -- Protein engineering and stabilization from sequence statistics: variation and covariation analysis -- Enzyme engineering by targeted libraries -- Generation of high-performance binding proteins for pepetide motifs by affinity clamping -- Engineering fibronectin-based binding proteins by yeast surface display -- Engineering and analysis of peptide-recognition domain specificities by phage display and deep sequencing -- Efficient sampling of SCHEMA chimera families to identify useful sequence elements -- Protein switch engineering by domain insertion -- Design of chimeric proteins by combination of subdomain-sized fragments -- [alpha]-helix mimicry with [alpha/beta]-peptides.
  • pt. B ScienceDirect
  • Phytoestrogens / B. Dave Oomah and Farah S. Hosseinian -- Analysis of fatty acids in functional foods with emphasis on [omega] 3 fatty acids and conjugated linoleic acid / Gary Dobson -- Analysis of flavonoids in functional foods and nutraceuticals / Laura Bravo and Raquel Mateos -- Exploitation of residues from vineyards, olive groves, and wine and oil production to obtain phenolic compounds of high-added value / María D. Luque de Castro, José M. Luque-Rodríguez, and Rafael Japón-Luján -- Anthocyanins / Gary Takeoka and Lan Dao -- Carotenoids and provitamin A in functional foods / María Isabel Mí́nguez-Mosquera, Dámaso Hornero-Méndez, and Antonio Pérez-Gálvez -- Chlorophylls / María Isabel Mí́nguez-Mosquera ... [et al.] -- Water-soluble vitamins / Míguel Ángel Fernández-Muiño, María Teresa Sancho-Ortiz, and Felicidad Valls-García -- Amino acid analysis / Larry R. Massom -- Carbohydrates and other electrochemically active compounds in functional foods / William R. LaCourse.
  • DSU Title III 2002-2012.
  • "Methods of Clinical Epidemiology" serves as a text on methods useful to clinical researchers. It provides a clear introduction to the common research methodology specific to clinical research for both students and researchers. This book sets out to fill the gap left by texts that concentrate on public health epidemiology and focuses on what is not covered well in such texts. The four sections cover methods that have not previously been brought together in one text and serves as a second level textbook of clinical epidemiology methodology. This book will be of use to postgraduate students in clinical epidemiology as well as clinical researchers at the start of their careers.
  • Methods of microarray data analysis v. 4-5, 2005-07.
    v. 5 (2007) Springer
  • Annotation Mercury (Hg) is a global pollutant that knows no environmental boundaries. Even the most stringent control of anthropogenic Hg sources will not eliminate exposure given its ubiquitous presence. Exposure to Hg occurs primarily via the food chain due to MeHgs accumulation in fish. Latest US statistics indicate that 46 States have fish consumption advisories. In addition, Hg is a common pollutant in hazardous waste sites, with an estimated 3-4 million children living within one mile of at least one of the 1,300+ active hazardous waste sites in the US. The effects on intellectual function in children prenatally exposed to MeHg via maternal fish consumption have been the subject of two on-going major, prospective, longitudinal studies in the Seychelles and the Faroe Islands. It is important to recognize that the risk for MeHg exposure is not limited only to islanders with high fish consumption. This bookwill provide state-of-the-art information to the graduate student training in toxicology, risk assessors, researchers and medical providers at large. It is aimed to bring the reader up to date on contemporary issues associated with exposure to methylmercury, from its effects on stem cells and neurons to population studies.
  • Methylxanthines 2011
    Notes on the History of Caffeine Use / Bertil B. Fredholm -- Distribution, Biosynthesis and Catabolism of Methylxanthines in Plants / Hiroshi Ashihara, Misako Kato and Alan Crozier -- Pharmacokinetics and Metabolism of Natural Methylxanthines in Animal and Man / Maurice J. Arnaud -- Inhibition of Cyclic Nucleotide Phosphodiesterases by Methylxanthines and Related Compounds / Sharron H. Francis, Konjeti R. Sekhar, Hengming Ke and Jackie D. Corbin -- Methylxanthines and Ryanodine Receptor Channels / Serge Guerreiro, Marc Marien and Patrick P. Michel -- Xanthines as Adenosine Receptor Antagonists / Christa E. Müller and Kenneth A. Jacobson -- Theobromine and the Pharmacology of Cocoa / Hendrik Jan Smit -- Propentofylline: Glial Modulation, Neuroprotection, and Alleviation of Chronic Pain / Sarah Sweitzer and Joyce De Leo -- Methylxanthines, Seizures, and Excitotoxicity / Detlev Boison -- Impacts of Methylxanthines and Adenosine Receptors on Neurodegeneration: Human and Experimental Studies / Jiang-Fan Chen and Yijuang Chern -- Methylxanthines and Pain / Jana Sawynok -- Methylxanthines and Sleep / Tarja Porkka-Heiskanen -- Methylxanthines and Reproduction / Alba Minelli and Ilaria Bellezza -- Methylxanthines During Pregnancy and Early Postnatal Life / Ulrika Ådén -- Methylxanthines and the Kidney / Hartmut Osswald and Jürgen Schnermann -- The Cardiovascular Effects of Methylxanthines / Niels P. Riksen, Paul Smits and Gerard A. Rongen -- Methylxanthines in Asthma / Stephen L. Tilley -- Methylxanthines and Inflammatory Cells / György Haskó and Bruce Cronstein -- Methylxanthines, Inflammation, and Cancer: Fundamental Mechanisms / Akio Ohta and Michail Sitkovsky -- Methylxanthines and Drug Dependence: A Focus on Interactions with Substances of Abuse / Micaela Morelli and Nicola Simola -- Methylxanthines and Human Health: Epidemiological and Experimental Evidence / Marie-Soleil Beaudoin and Terry E. Graham.
  • A new paradigm -- Clinical embryology of the abdomen -- Clinical anatomy of the abdomen -- Mechanisms of spread of disease in the abdomen and pelvis -- Intraperitoneal spread of infections and seeded metastases -- The extraperitoneal spaces: normal and pathologic anatomy -- The extraperitoneal pelvic compartments -- Patterns of spread of disease from the liver -- Patterns of spread of disease from the distal esophagus and stomach -- Patterns of spread of disease from the pancreas -- Patterns of spread of disease from the small intestine -- Patterns of spread of disease from the large intestine -- Patterns of spread of renal, upper urothelial, and adrenal pathology -- Patterns of spread of disease of the pelvis and male urogenital organs -- Patterns of spread of gynecologic disease -- Patterns of extraabdominal and extrapelvic spread -- Internal abdominal hernias.
  • Corticosteroids and related drugs -- Prostaglandins -- Sex hormones and related drugs -- Iodine and drugs that affect thyroid function -- Insulins and other hypoglycemic drugs -- Other hormones and related drugs -- Lipid-regulating drugs -- Endocrine and metabolic adverse effects of non-hormonal and non-metabolic drugs.
  • Elsevier now offers a series of derivative works based on the acclaimed Meyler's Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing biomedical researcher and/or clinician. Opioids and analgesics are members of a diverse group of drugs used to relieve pain. They are frequently used in combination with prescription and nonprescription pain relievers, and misuse is prevalent. Pain medicine specialists and most physicians or surgeons will find this volume useful in prescribing the appropriate drugs for pain therapy and for preventing mi.
  • Antibacerial Drugs -- Antiviral Drugs, Including Immunoglobulins and Interferons -- Antifungal Drugs -- Antiprotozoal and Antihelminthic Drugs -- Vaccines -- Disinfectants and Antiseptics.
  • Elsevier now offers a series of derivative works based on the acclaimed Meylers Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician or health care clinician. Each year, heart disease kills more people than cancer. Patients are treated by a variety of specialists and primary care practitioners, depending on the organ system involved. This volume enables practitioners to assess the adverse effects of the complete range of drugs used in cardiovascular medicine, including antihypertensive drugs, and drugs used in the treatment.
  • Drugs Used in Cancer Chemotherpy -- Corticosteroids and Prostaglandins -- Cytokines and Cytokine Modulators Interferons -- Monoclonal Antibodies -- Immune Modulators.
  • Elsevier now offers a series of derivative works based on the acclaimed Meyler's Side Effect of Drugs, 15th Edition. These individual volumes are grouped by specialty to benefit the practicing physician and/or clinician. Many of the drugs currently available to physicians have a long history of use as herbal remedies, including opium, aspirin, digitalis, and quinine. This volume will be a reference to health professionals and homeopathic practitioners in understanding the effects of herbal drugs. Surpasses the Physician's Desk Reference © by including clinical case studies and independent exper.
  • Antidepressants -- Neuroleptic Drugs -- Hypnosedatives -- Drugs of Abuse -- Drugs use in Alzheimer's Disease -- Psychological and Psychiatric Adverse Effects of Non-Psychoactive Drugs.
  • Preparing for the cardiology board examination is an intensely stressful period and traditionally relies on the participant searching through their own references, whether that be the large textbooks, small handbooks and their own notes. Good books are generally too long and time-consuming, while shorter books are either insubstantial in content or rely too much on the views of one author. The key elements for a successful reference for those taking their boards are a balanced proportion of essential content alongside rare but frequently tested topics, the wisdom of experts in the field, a practical questions session at the end of every topic and additional visuals not possible on the two-dimensional page. In the MGH Cardiology Board Review, the Editors have compiled the expertise of over 72 experienced authors from the Mass General in a succinct volume, applying methods thoroughly tested in the Board Review Conference. In addition, two very important sections are included on ECGs and images, contents of which are derived from the board examination answer keys, the very ones that readers are expected to know. Plans on how to best approach the board examination preparation and what additional resources to go to are provided. In short, this book has all the strengths to ensure your success on the boards exam.
  • 1. Anesthesia equipment and patient safety / Arna Banerjee, L. Jane Easdown, and Matthew B. Weinger -- 2. Medical gases: properties, supply, and removal / Jesse M. Ehrenfeld and Michael Oleyar -- 3. Anesthesia machine: a practical overview / Jeffrey M. Feldmann -- 4. Principles and practices of closed circuit anesthesia / Robert S. Holzman and Rebecca Lintner -- 5. Manual and mechanical ventilators / Demet Suleymanci, Robert M. Kacmarek, and Yandong Jiang -- 6. Supraglottic airway devices / Jordan L. Newmark and Warren S. Sandberg -- 7. Intubation equipment / Zhongcong Xie, Ali Diba, and Zhipeng Xu -- 8. Endotracheal airway devices / Young K. Ahn and Warren S. Sandberg -- 9. Noninvasive physiological monitors / Jordan L. Newmark and Warren S. Sandberg -- 10. Invasive hemodynamic monitoring / Beverly J. Newhouse and Rafael Montecino -- 11. Transesophageal echocardiography / Jacob Kaczmarski and Sugantha Sundar -- 12. Depth of anesthesia monitoring: principles and applications / Roy Esaki and George Mashour -- 13. Alarms in clinical anesthesia / F. Jacob Seagull and Richard P. Dutton -- 14. Equipment for regional anesthesia and acute pain management / Reuben Slater and Lisa Warren -- 15. Ultrasound for regional anesthesia and vascular access / Lisa Warren and Reuben Slater -- 16. Intravenous therapy, fluid delivery systems for resuscitation, and cell salvage devices / Vanessa G. Henke and Warren S. Sandberg -- 17. Drug infusion pumps in anesthesia, critical care, and pain management / Nathaniel Sims ... [et al.] -- 18. Devices for cardiac support / Michael G. Fitzsimons, Stephanie Ennis, and Thomas MacGillivray -- 19. Patient warming devices / Jennifer A. Chatburn and Warren S. Sandberg -- 20. Point-of-care testing in the operating room / Marianna P. Crowley -- 21. Anesthesia information management systems / Sachin Kheterpal -- 22. Pediatric considerations / Rebecca N. Lintner and Robert S. Holzman -- 23. Anesthesia equipment outside of the operating room / Sergio D. Bergese, Erika G. Puente, and Gilat Zisman -- 24. Provision of anesthesia in difficult situations and the developing world / Deborah J. Harris ... [et al.] -- 25. Prevention of infection: disinfection and sterilization of equipment / Arnold J. Berry -- 26. Legal and regulatory issues / Eric T. Pierce -- 27. Physical principles / Paul D. Davis -- 28. Basic physics of electricity / Paul D. Davis -- 29. Operating room electrical, fire, laser, and radiation safety / Anuja K. Antony, Chunbai Zhang, and William G. Austen -- 30. Neuroanesthesia equipment in the intraoperative setting / Sergio D. Bergese, Gilat Zisman, and Erika G. Puente.
  • Overview of MHC Class I Antigens -- HLA Class I Expression in Human Cancer -- MHC Class I Expression in Experimental Mouse Models of Cancer: Immunotherapy of Tumors with Different MHC-I Expression Patterns -- Potential Therapeutic Approaches for Increasing Tumor Immunogenicity by Upregulation of Tumor HLA Class I Expression -- Conclusions.
  • MHC protocols 2002
    Springer Protocols
  • The mhGAP-IG has been developed through an intensive process of evidence review. A WHO Guideline Development Group of international experts conducted systematic reviews to develop evidence-based recommendations. The recommendations were then converted into clearly presented stepwise interventions and then circulated among a wider range of reviewers across the world to include all the diverse contributions. The mhGAP-IG is based on the mhGAP Guidelines on interventions for mental, neurological and substance use disorders (http:// Both documents will be reviewed and updated in 5 years. Any revision and update before that will be made to the online version of the document.--(excerpt, p. 1).
    NCBI Bookshelf
    This searchable database is a collection of in vivo molecular imaging agents developed for positron emission tomography (PET), single photon emission computed tomography (SPECT), magnetic resonance imaging (MRI), ultrasound (US), computed tomography (CT), and optical imaging. MICAD, a key component of the "Molecular Libraries and Imaging" program of the NIH Roadmap, is being developed by NCBI, the National Center for Biotechnology Information".
  • Micellar catalysis 2007
  • Print Material
  • Interfacing biological material with micro- and nanodevices / Jaime Castillo-León and Winnie E. Svendsen -- Atomic force microscopy for liquid applications / Zachary James Davis -- Manipulation by electrical fields / Maria Dimaki -- Optical manipulation techniques / Kirstine Berg-Sørensen -- Ultrasonic manipulation techniques / Stefano Oberti and Jürg Dual -- 3D biomanipulation using microgrippers / Peter Bøggild -- Magnetic manipulation of biological structures / Maria Dimaki and Winnie E. Svendsen -- Microfluidic manipulation of biological samples / Fridolin Okkels.
  • DNA microarray technology. Introduction / J.R. Pollack -- Comparative genomic hybridization on BAC arrays / B.P. Coe ... [et al.] -- Comparative genomic hybridization on spotted oligonucleotide microarrays / Y.H. Kim and J.R. Pollack -- Comparative genomic hybridization by representational oligonucleotide microarray analysis / R. Lucito and J. Byrnes -- Application of oligonucleotides arrays for coincident comparative genomic hybridization, ploidy status and loss of heterozygosity studies in human cancers / J.K. Cowell and K.C. Lo -- Molecular inversion probe assay for allelic quantitation / H. Ji and K. Welch -- A whole-genome amplification protocol for a wide variety of DNAs, including those from formalin-fixed and paraffin-embedded tissue / P.L. Paris -- Algorithms for calling gains and losses in array CGH data / P. Wang -- Methylation analysis by microarray / D.E. Deatherage ... [et al.] -- Methylation analysis by DNA immunoprecipitation (MeDIP) / E.A. Vucic ... [et al.] -- Combining chromatin immunoprecipitation and oligonucleotide tiling arrays (ChIP-Chip) for functional genomic studies / J. Eeckhoute, M. Lupien and M. Brown -- ChIP-Chip: algorithms for calling binding sites / X.S. Liu and C.A. Meyer -- Mapping regulatory elements by DNaseI hypersensitivity chip (DNase-Chip) / Y. Shibata and G.E. Crawford -- Microarray analysis of DNA replication timing / N. Karnani, C.M. Taylor and A. Dutta -- Integration of diverse microarray data types / K. Salari and J.R. Pollack.
  • Microarray Image and Data Analysis: Theory and Practice is a compilation of the latest and greatest microarray image and data analysis methods from the multidisciplinary international research community. Delivering a detailed discussion of the biological aspects and applications of microarrays, the book:Describes the key stages of image processing, gridding, segmentation, compression, quantification, and normalizationFeatures cutting-edge approaches to clustering, biclustering, and the reconstruction of regulatory networksCovers different ty.
  • Introduction to microarray technologies / Robert S. Matson -- Nucleic acid sample preparation / Robert S. Matson -- Solid-phase substrates for nucleic acid microarrays / Robert S. Matson -- Protein sample preparation for microarrays / Robert S. Matson -- Solid-phase chemistries for protein microarrays / Robert S. Matson -- Protein microarrays : the link between genomics and proteomics / Persis P. Wadia and David B. Miklos -- Bead arrays : an introduction to multiplexed bead-based assays for proteins / Yong Song -- Carbohydrate arrays / Denong Wang -- Lectin microarrays / Masao Yamada -- Printing methods / Todd Martinsky.
  • Manufacturing of microarrays -- Technological platforms for microarray gene expression profiling -- Principles of gene microarray data analysis -- Gaining weights ... and feeling good about it! -- Complementary techniques -- Microarrays for cancer diagnosis and classification -- Gene profiling for the prediction of tumor response to treatment: the case of immunotherapy -- Identification of molecular determinants of tumor sensitivity and resistance to anticancer drugs -- SNP and mutation analysis -- Cancer development and progression -- Gene expression profiling in malignant lymphomas -- Tumor immunology.
  • pt. 1. General microarray technologies -- pt. 2. DNA microarrays -- pt. 3. Protein microarrays -- pt. 4. Cell & tissue microarrays.
  • Microarray technology has made strong progress over the past decade, and there have also been significant changes in application areas, from nucleic acids to proteomics and from research to clinical applications. This book provides a comprehensive overview of microarrays in diagnostics and biomarker development, covering DNA, peptide, protein and tissue arrays. The focus is on entities that are in actual clinical use, or quite close, and on recent developments, such as peptide and aptamer arrays. A further topic is the miniaturisation towards nanoarrays, which is expected to have great potential in clinical applications. Relevant issues of bioinformatics and statistical analysis of array data are discussed in detail, as well as the barriers to the commercialisation of array-based tests and the vexing IP issues involved. Thus, the book should be very useful tor active array users as well as to newcomers seeking to make the best choice between different technologies.
  • Microarrays. 2nd ed. v. 1-2, 2007.
    Springer Protocols
    v.2, 2009 Springer Protocols
    v. 1. Synthesis methods -- v. 2. Applications and data analysis.
  • Bacterial growth -- The outer membrane of gram-negative bacteria and the cytoplasmic membrane -- Peptidoglycan synthesis and cell division -- Cellular permeability -- Allosteric enzymes -- Glycolysis, gluconeogenesis and glycogen synthesis -- The pentose phosphate and Entner-Doudoroff pathways -- The tricarboxylic acid cycle and the glyoxylate bypass -- ATP-generating processes : respiration and fermentation -- Biosynthesis of lipids -- Iron-sulfur proteins -- The archaea -- Methanogens and methylotrophs -- Enzyme induction in catabolic systems -- Transcription : RNA polymerase -- Negative regulation -- Enzyme repression in anabolic pathways -- Positive regulation -- The ribosomes -- The genetic code, the transfer RNAs and the aminoacyl-tRNA-synthetases -- Attenuation -- Riboswitches -- The biological fixation of nitrogen -- How biosynthetic pathways have been established -- The aspartic acid family of amino acids : biosynthesis -- Regulation of the biosynthesis of the amino acids of the aspartic acid family in Enterobacteriaceae -- Other patterns of regulation of the synthesis of amino acids of the aspartate family -- Biosynthesis of the amino acids of the glutamic acid family and its regulation -- Biosynthesis of amino acids derived from phosphoglyceric acid and pyruvic acid -- Selenocysteine and selenoproteins -- Biosynthesis of aromatic amino acids and its regulation -- The biosynthesis of histidine and its regulation -- The biosynthesis of nucleotides -- The biosynthesis of deoxyribonucleotides -- Biosynthesis of some water-soluble vitamins and of their coenzyme forms -- Biosynthesis of carotene, vitamin A, sterols, ubiquinones and menaquinones -- Biosynthesis of the tetrapyrrole ring system -- Biosynthesis of cobalamins including vitamin B12 -- Interactions between proteins and DNA -- Evolution of biosynthetic pathways.
  • Antibiotic resistance : postantibiotic era is here / Vladimir Krcmery -- Current challenges in treating methicillin-resistant Staphylococcus aureus : what are the options? / Noha E.I. Sakka & Ian M . Gould -- Antimicrobial-resistant Streptococcus pneumoniae : trends and management / Michael R. Jacobs -- Emergence and management of drug-resistant enterococcal infections / William R. Miller, Barbara E. Murray & Cesar A. Arias -- Enterobacteriaceae that produce newer b-lactamases / Johann D.D. Pitout -- Extensively drug-resistant tuberculosis : new strains, new challenges / Megan Coffee -- Clinical significance of extended-spectrum b-lactamases / Jesés Rodréguez-Baño, Belén Gutiérrez, Lorena Lépez-Cerero & Alvaro Pascual -- Plasmid-mediated quinolone resistance / José Manuel Rodréguez-Marténez, Maréa Eliecer Cano, Jorge Calvo, Álvaro Pascual & Luis Marténez-Marténez -- Antibiotic resistance in the absence of antimicrobial use / Lucia Pallecchi, Alessandro Bartoloni, Eduardo Gotuzzo & Gian Maria Rossolini -- Resistance in bacteria of the food chain : epidemiology and control strategies / Lina Maria Cavaco & Frank Møller Aarestrup -- Measures to prevent antimicrobial resistance / Vhairi M. Bateman & Ian M. Gould -- Where does novel antibiotics R&D stand among other pharmaceutical products? / Glenn S. Tillotson -- Resistance to antiretroviral drugs / Manuela Colafigli, Simona Di Giambenedetto & Roberto Cauda -- Index.
  • "The field of microbial endocrinology is expressly devoted to understanding the mechanisms by which the microbiota (bacteria within the microbiome) interact with the host ("us"). This interaction is a two-way street and the driving force that governs these interactions are the neuroendocrine products of both the host and the microbiota. Chapters include neuroendocrine hormone-induced changes in gene expression and microbial endocrinology and probiotics. This is the first in a series of books dedicated to understanding how bi-directional communication between host and bacteria represents the cutting edge of translational medical research, and hopefully identifies new ways to understand the mechanisms that determine health and disease"--Publisher's description.
  • Preface: Food--A Necessity and a Threat -- Editor -- Contributors -- Section I. Instances and Nature of Microbial Food Contamination -- 1. PulseNet and Emerging Foodborne Diseases / Efrain M. Ribot, Eija Hyytia-Trees, and Kara Cooper -- 2. Pathogenic Mechanisms of the Enterohemorrhagic
  • Microbial forensics 2005
  • Overview of whole-genome essentiality analysis / Karen Joy Shaw -- Pt. I. Experimental protocols. IA. Populational genome-wide essentiality screens. Transposon-based strategies for the identification of essential bacterial genes / William S. Reznikoff and Kelly M. Winterberg -- Identification and analysis of essential genes in Haemophilus influenzae / Sandy M.S. Wong and Brian J. Akerley -- Transposon site hybridization in Mycobacterium tuberculosis / Jeffrey P. Murry ... [et al.] -- Essential genes in the infection model of Pseudomonas aeruginosa PCR-based signature-tagged mutagenesis / François Sanschagrin, Irena Kukavica-Ibrulj, and Roger C. Levesque -- Whole-genome detection of conditionally essential and dispensable genes in Escherichia coli via genetic footprinting / Michael D. Scholle and Svetlana Y. Gerdes -- Generating a collection of insertion mutations in the Staphylococcus aureus genome using bursa aurealis / Taeok Bae ... [et al.] -- Multipurpose transposon insertion libraries for large-scale analysis of gene function in yeast / Anuj Kumar -- IB. Systematic collections of knockout mutants. How to make a defined near-saturation mutant library. Case 1: Pseudomonas aeruginosa PAO1 / Michael A. Jacobs -- Comparing insertion libraries in two Pseudomonas aeruginosa strains to assess gene essentiality / Nicole T. Liberati ... [et al.] -- The construction of systematic in-frame, single-gene knockout mutant collection in Escherichia coli K-12 / Tomoya Baba and Hirotada Mori -- The applications of systematic in-frame, single-gene knockout mutant collection of Escherichia coli K-12 / Tomoya Baba ... [et al.] -- A novel, simple, high-throughput method for isolation of genome-wide transposon insertion mutants of Escherichia coli K-12 / Takeyoshi Miki, Yoshihiro Yamamoto, and Hideo Matsuda -- High-throughput creation of a whole-genome collection of yeast knockout strains / Angela M. Chu and Ronald W. Davis -- Analysis of genetic interactions on a genome-wide scale in budding yeast: diploid-based synthetic lethality analysis by microarray / Pamela B. Meluh ... [et al.] -- IC. Genome minimization. Scarless engineering of the Escherichia coli genome / Tamás Fehér ... [et al.] -- Minimization of the Escherichia coli genome using the Tn5-targeted Cre/loxP excision system / Byung Jo Yu and Sun Chang Kim -- Construction of long chromosomal deletion mutants of Escherichia coli and minimization of the genome / Jun-ichi Kato and Masayuki Hashimoto -- ID. Conditional knockouts. Identification of essential genes in Staphylococcus aureus by construction and screening of conditional mutant library / Dezhong Yin and Yinduo Ji -- Techniques for the isolation and use of conditionally expressed antisense RNA to achieve essential gene knockdowns in Staphylococcus aureus / Allyn Forsyth and Liangsu Wang -- Introduction of conditional lethal amber mutations in Escherichia coli / Christopher D. Herring -- Pt. II. Bioinformatics. IIA. Statistics. Statistical methods for building random transposon mutagenesis libraries / Oliver Will -- Statistical evaluation of genetic footprinting data / Gábor Balázsi -- Modeling competitive outgrowth of mutant populations : why do essentiality screens yield divergent results? / Alexander I. Grenov and Svetlana Y. Gerdes -- Statistical analysis of fitness data determined by TAG hybridization on microarrays / Brian D. Peyser, Rafael Irizarry, and Forrest A. Spencer -- IIB. Data integration and modeling. Profiling of Escherichia coli chromosome database / Yukiko Yamazaki, Hironori Niki, and Jun-ichi Kato -- Gene essentiality analysis based on DEG, a database of essential genes / Chun-Ting Zhang and Ren Zhang -- Detection of essential genes in Streptococcus pneumoniae using bioinformatics and allelic replacement mutagenesis / Jae-Hoon Song and Kwan Soo Ko -- Design and application of genome-scale reconstructed metabolic models / Isabel Rocha, Jochen Förster, and Jens Nielsen -- Predicting gene essentiality using genome-scale in silico models / Andrew R. Joyce and Bernhard Ø. Palsson -- Comparative approach to analysis of gene essentiality / Andrei L. Osterman and Svetlana Y. Gerdes.
  • A paradigm for commensalism : the role of a specific microbial polysaccharide in health and disease / Kasper, D.L. -- The hygiene hypothesis : do we still believe in it? / Björkstén, B. -- "ABC" of mucosal immunology / Brandtzaeg, P. -- Innate and adaptive immune pathways to tolerance / Thornton, C.A., Morgan, G. -- Hitting the mucosal road in tolerance induction / Wiedermann, U. -- Obesity : extending the hygiene hypothesis / Isolauri, E. ... [et al.] -- Autoimmunity and diet / Cerf-Bensussan, N. -- Eosinophilic esophagitis : example of an emerging allergic manifestation? / Heine, R.G. -- Microbial-host interactions in inflammatory bowel diseases and experimental colitis / Sartor, R.B. -- Development and regulation of immune responses to food antigens in pre- and postnatal life / Renz, H. ... [et al.] -- Novel approaches in treating food allergy using allergens / Rancé, F. -- Allergen avoidance approaches in food allergy management / Koletzko, S., Koletzko, B. -- Role of dietary immunomodulatory factors in the development of immune tolerance / Prescott, S.L. -- Microbial host interactions : selecting the right probiotics and prebiotics for infants / Salminen, S. ... [et al.] -- Probiotics and prebiotics : immunological and clinical effects in allergic disease / Tang, M.L.K. -- Modified proteins in allergy prevention / von Berg, A.
  • Microbial imaging. 1st ed. 2005
  • This new volume of Methods in Enzymology continues the legacy of this premier serial with quality chapters authored by leaders in the field. This volume covers microbial metagenomics, metatranscriptomics, and metaproteomics, and includes chapters on such topics as in-solution FISH for single cell genome preparation, preparation of BAC libraries from marine microbial community DNA, and preparation of microbial community cDNA for metatranscriptomic analysis in marine plankton. Continues the legacy of this premier serial with quality chapters authored by leaders in the field.
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    "The book starts with dissecting mechanisms underlying viral immune evasion via exploiting the host complement system by vaccinia virus, and by modulating the type 1 interferon response by RNA viruses. Yet another chapter looks into how viroporins expressed by different families of viruses causing influenza A virus, SARS, hepatitis C and HIV interact with several cellular pathways. Understanding of these mechanisms can aid the development of novel potential anti-viral targets. The chapter on tuberculosis discusses the emerging importance of the innate immune mechanisms against Mycobacterium tuberculosis infection and latency. This book has a strong focus on fungal pathogenesis and immunity, starting with virulence and host factors that attain great importance in candidiasis and associated escape tricks of seriously opportunistic fungi. Two chapters on Aspergillus fumigatus elaborate on the pathogenic mechanisms: first discussing A. fumigatus-airway epithelium interaction, followed by fungal and host factors that are paramount in the development of allergic and invasive aspergillosis. In the subsequent chapter, there is a general discussion on the innate and adaptive immune responses against primary and opportunistic fungal pathogens"--Publisher's description.
  • Genome comparison of bacterial pathogens / Wassenaar, T.M. ... [et al.] -- In silico reconstruction of the metabolic and pathogenic potential of bacterial genomes using subsystems / McNeil, L.K., Aziz, R.K. -- The bacterial pan-genome and reverse vaccinology / Tettelin, H. -- 'Guilty by association' : protein-protein interactions (PPIS) in bacterial pathogens / Schauer, K., Stingl, K -- Helicobacter pylori sequences reflect past human migrations / Moodley, Y., Linz, B. -- Helicobacter pylori genome plasticity / Baltrus, D.A., Blaser, M.A., Guillemin, K. -- Genomics of Thermophilic campylobacter species / Gaskin, D.J.H. ... [et al.] -- Adaptation of pathogenic E. coli to various niches : genome flexibility is the key / Brzuszkiewicz, E. ... [et al.] -- Role of horizontal gene transfer in the evolution of Pseudomonas aeruginosa virulence / Qiu, X., Kulasekara, B.R., Lory, S. -- The genus Burkholderia : analysis of 56 genomic sequences / Ussery, D.W. ... [et al.] -- Genomics of host-restricted pathogens of the genus Bartonella / Engel, P., Dehio, C. -- Legionella pneumophila - host interactions : insights gained from comparative genomics and cell biology / Lomma, M. ... [et al.] -- A proteomics view of virulence factors of Staphylococcus aureus / Engelmann, S., Hecker, M. -- Pathogenomics of mycobacteria / Gutierrez, M.C., Supply, P., Brosch, R.
  • Microbial processes and products 2005
    Springer Protocols
  • Diphtheria toxin, diphtheria-related fusion protein toxins, and the molecular mechanism of their action against eukaryotic cells -- Anthrax toxin and genetic aspects regulating its expression -- Shiga toxins and their mechanisms of cell entry -- Cholera toxin: mechanisms of entry into host cells -- ExoU: a cytotoxin delivered by the type III secretion system of pseudomonas aeruginosa -- Staphylococcal alpha-toxin -- S. cerevisiae K28 toxin- a secreted virus toxin of the A/B family of protein toxins -- Kluyveromyces lactis zymocin and other plasmid-encoded yeast killer toxins -- The ustilago maydis killer toxins -- Zygocin- a monomeric protein toxin secreted by virus-infected zygosaccharomyces bailii -- Acidophilic structure and killing mechanism of the pichia farinosa killer toxin SMKT.
  • "Discover important lessons learned about whole organism biology via microbial proteomics This text provides an exhaustive analysis and presentation of current research in the field of microbial proteomics, with an emphasis on new developments and applications and future directions in research. The editors and authors show how and why the relative simplicity of microbes has made them attractive targets for extensive experimental manipulation in a quest for both improved disease prevention and treatment and an improved understanding of whole organism functional biology. In particular, the text demonstrates how microbial proteomic analyses can aid in drug discovery, including identification of new targets, novel diagnostic markers, and lead optimization. Each chapter is written by one or more leading experts in the field and carefully edited to ensure a consistent and thorough approach throughout. Methods, technologies, and tools associated with the most promising approaches are stressed."--Publisher's website.
  • Chapter 1: Overview -- Chapter 2: Performance Criteria -- Chapter 3: Library-dependent Source Tracking Methods -- Chapter 4: Library-Independent Source Tracking Methods -- Chapter 5: Viruses as Tracers of Fecal Contamination -- Chapter 6: Phage Methods -- Chapter 7: Pathogenic Protozoa -- Chapter 8: Chemical-Based Fecal Source Tracking Methods -- Chapter 9: Statistical Approaches for Modeling in Microbial Source Tracking -- Chapter 10: Mitochondrial DNA as Source Tracking Markers of Fecal Contamination -- Chapter 11: Community Analysis-Based Methods -- Chapter 12: Public Perception of and Public Participation in Microbial Source Tracking -- Chapter 13: Use of Microbial Source Tracking in the Legal Arena: Benefits and Challenges -- Chapter 14: Applications of Microbial Source Tracking in the TMDL Process -- Chapter 15: Relating MST Results to Fecal Indicator Bacteria, Pathogens, and Standards -- Chapter 16: Minimizing Microbial Source Tracking at All Costs -- Chapter 17: Environmental Persistence and Naturalization of Fecal Indicator Organisms -- Chapter 18: Agricultural and Rural Watersheds -- Chapter 19: Case Studies of Urban and Suburban Watersheds -- Chapter 20: Beaches and Coastal Environmenta -- Chapter 21: Source tracking in Australia and New Zealand: Case Studies -- Chapter 22: Microbial Source Tracking in China and Developing Nations -- Chapter 23: A National Security Perspective of Microbial Source Tracking -- Chapter 24: Applications of Quantitative Microbial Source Tracking (QMST) and Quantitative Microbial Risk Assessment (QMRA) -- Chapter 25: Food Safety and Implications for Microbial Source Tracking -- Chapter 26: Training Future Scientists: Teaching Microbial Source Tracking (MST) to Undergraduates -- Index.
  • Genetics and genomics of sulfate respiration in desulfovibrio / Judy D. Wall ... [et al.] -- Living on sulfate : three-dimensional structure and spectroscopy of adenosine 5'-phosphosulfate reductase and dissimilatory sulfite reductase / Günter Fritz ... [et al.] -- Respiratory membrane complexes of Desulfovibrio / Inês A. Cardoso Pereira -- Biochemical and evolutionary aspects of eukaryotes that inhabit sulfidic environments / Ursula Theissen, William Martin -- Evolution and ecology of microbes dissimilating sulfur compounds : insights from siroheme sulfite reductases / Alexander Loy, Stephan Duller, Michael Wagner -- Genomic and evolutionary perspectives on sulfur metabolism in green sulfur bacteria / Niels-Ulrik Frigaard, Donald A. Bryant -- Differential-expression proteomics for the study of sulfur metabolism in the chemolithoautotrophic Acidithiobacillus ferrooxidans / Lissette Valenzuela ... [et al.] -- Sulfur and light? History and "thiology" of the phototrophic sulfur bacteria / Hans G. Trüper -- Thiosulfate and sulfur oxidation in purple sulfur bacteria / Frauke Grimm, Bettina Franz, Christiane Dahl -- Sulfur oxidation in Chlorobium tepidum (syn. Chlorobaculum tepidum) : genetic and proteomic analyses / Leong-Keat Chan, Rachael Morgan-Kiss, Thomas E. Hanson -- Structural insights into component SoxY of the thiosulfate-oxidizing multienzyme system of Chlorobaculum thiosulfatiphilum / Jan Stout ... [et al.] -- Redox control of chemotrophic sulfur oxidation of Paracoccus pantotrophus / Cornelius G. Friedrich ... [et al.] -- Bacterial sulfite-oxidizing enzymes : enzymes for chemolithotrophs only? / Ulrike Kappler -- Sulfonates and organotrophic sulfite metabolism / Alasdair M. Cook, Theo H.M. Smits, Karin Denger -- Oxidation of sulfur and inorganic sulfur compounds in Acidianus ambivalens / Arnulf Kletzin -- A novel coenzyme F420 dependent sulfite reductase and a small sulfite reductase in methanogenic archaea / Eric F. Johnson, Biswarup Mukhopadhyay -- Archaeal and bacterial sulfur oxygenase-reductases : genetic diversity and physiological function / Shuang-Jiang Liu -- Diversity of halophilic sulfur-oxidizing bacteria in hypersaline habitats / Dimitry Y. Sorokin -- Sulfur oxidation at deep-sea hydrothermal vents / Stefan M. Sievert ... [et al.] -- Speciation analysis of microbiologically produced sulfur by X-ray absorption near edge structure spectroscopy / Alexander Prange -- Controls on isotope fractionation during dissimilatory sulfate reduction / Joost Hoek, Donald E. Canfield -- Bioprocess engineering of sulfate reduction for environmental technology / Piet N.L. Lens ...[et al.] -- Impact of nitrate on the sulfur cycle in oil fields / Gerrit Voordouw.
  • Computational intelligence in the design of synthetic microbial genetic systems / Jennifer S. Hallinan -- Constraints in the design of the synthetic bacterial chassis / Antoine Danchin and Agnieszka Sekowska -- Social dimensions of microbial synthetic biology / Jane Calvert, Emma Frow -- Bacillus subtilis: model gram-positive synthetic biology chassis / Colin R. Harwood, Suzanne Pohl, Wendy Smith, Anil Wipat -- Engineering microbial biosensors / Lisa Goers, Nicolas Kylilis, Marios Tomazou, Ke Yan Wen, Paul Freemont, Karen Polizzi -- Noise and stochasticity in gene expression: a pathogenic fate determinant / Mikkel Girke Jørgensen, Renske van Raaphorst, Jan-Willem Veening -- Platforms for genetic design automation / Chris J. Myers.
  • Type of human disease by source of the infectious agent -- A history of zoonoses and sapronoses and research into them -- The infection process in zoonoses and sapronoses -- The epidemic process in zoonoses and sapronoses -- Haematophagous arthropods as vectors of diseases -- Vertebrates as hosts and reservoirs of zoonotic microbial agents -- Systematic survey of zoonoses and sapronoses microbial agents.
  • One of the most promising new approaches for the prevention of HIV transmission, particularly for developing countries, involves topical, self-administered products known as microbicides. The development of microbicides is a long and complicated process, and this volume provides an overview of all the critical areas, from the selection of appropriate candidate molecules and their formulation, preclinical and clinical testing for safety and efficacy, strategies for product registration and finally, issues associated with product launch, distribution and access. The book will prove valuable to both those working in the field and all others who are interested in learning more about this product class, which has the potential to significantly impact the future of this devastating epidemic.
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    Problems linked with pathogens in fresh produce, including the associated public health and trade implications, have been reported in a number of countries worldwide. Furthermore, from 1980 to 2004, the global production per annum of fruit and vegetables grew by 94% and they are a critical component of a healthy diet. Reported outbreaks associated with leafy vegetables and herbs have been notable for the wide geographical distribution of the contaminated products, the high numbers of consumers exposed and thus the large number of cases. This meeting addressed the pathways for contamination, survival and persistence of microbiological hazards associated with leafy vegetables and herbs, and the potential management options from primary production through to the consumer.--Publisher's description.
  • Microbiology monographs v. 1-, 2006-
  • The second edition of Microbiology of Waterborne Diseases describes the diseases associated with water, their causative agents and the ways in which they gain access to water systems. The book is divided into sections covering bacteria, protozoa, and viruses. Other sections detail methods for detecting and identifying waterborne microorganisms, and the ways in which they are removed from water, including chlorine, ozone, and ultraviolet disinfection. The second edition of this handbook has been updated with information on biofilms and antimicrobial resistance. The impact of global warming and climate change phenomena on waterborne illnesses are also discussed. This book serves as an indispensable reference for public health microbiologists, water utility scientists, research water pollution microbiologists environmental health officers, consultants in communicable disease control and microbial water pollution students. Focuses on the microorganisms of most significance to public health, including E. coli, cryptosporidium, and enterovirus. Highlights the basic microbiology, clinical features, survival in the environment, and gives a risk assessment for each pathogen. Contains new material on antimicrobial resistance and biofilms. Covers drinking water and both marine and freshwater recreational bathing waters.
  • Microbiology of wounds 2010
    An introduction to the world of microbiology and biofilmology / Steven L. Percival, John G. Thomas, and David Williams -- Human skin and microbial flora / Rose A. Cooper and Steven L. Percival -- An introduction to wounds / Michel H.E. Hermans and Terry Treadwell -- Burn wound management / Michel H.E. Hermans -- Cell biology of normal and impaired healing / Keith Moore -- The microbiology of wounds / Steven L. Percival and Scott E. Dowd -- Types of wounds and infections / Randall D. Wolcott ... [et al.] -- Biofilms and significance to wound healing / Keith F. Cutting ... [et al.] -- Wounds, enzymes, and proteases / Steven L. Percival and Christine A. Cochrane -- Wound healing immunology and biofilms / Emma J. Woods ... [et al.] -- Antimicrobial interventions for wounds / Steven L. Percival, Rose A. Cooper, and Benjamin A. Lipsky -- Wound dressings and other topical treatment modalities in bioburden control / Richard White -- Factors affecting the healing of chronic wounds : an iconoclastic view / Marissa J. Carter and Caroline E. Fife.
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    Basic bacteriology -- Genetics -- Antimicrobial agents -- General medical microbiology -- Gram-positive cocci -- Gram-negative cocci -- Gram-positive and acid-fast bacilli -- Gram-negative bacilli -- Anaerobes -- Spirochetes -- Atypical pathogenic bacteria : mycoplasma, rickettsia, ehrlichia, anaplasma, chlamydia, and chlamydophila -- Virology -- Mycology -- Parasitology -- Random pearls.
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    High Yield Facts -- Physiology and Molecular Microbiology -- Virology -- Bacteriology -- Rickettsiae, Chlamydiae, and Mycoplasms -- Mycology -- Parasitology -- Immunology.
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    1. Virology, immunology, parasitology, mycology -- 2. Bacteriology.
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    v. 1. Virology, immunology, parasitology, mycology -- v. 2. Bacteriology.
  • Microchip methods in diagnostics 2009
    Springer Protocols
    DNA microarrays: an introduction to the technology / Ursula Bilitewski -- Discussion of the applicability of microarrays: profiling of leukemias / Torsten Haferlach ... [et al.] -- Expression profiling using Affymetrix GeneChip microarrays / Herbert Auer, David L. Newsom, and Karl Kornacker -- Genotyping of mutation in the beta-globin gene using DNA microarrays / Martin Dufva and Lena Poulsen -- Antibody-based microarrays / Christer Wingren and Carl A.K. Borrebaeck -- Application of protein ArrayTubes to bacteria, toxin, and biological warfare agent detection / Ralf Ehricht ... [et al.] -- Detection of known allergen-specific IgE antibodies by immunological methods / Barbara I. Fall and Reinhard NieSner -- Peptide microarrays for serum antibody diagnostics / Heiko Andresen and Frank F. Bier -- Microchips for cell-based assays / Martin Dufva -- Bio-cell chip fabrication and applications / Honggu Chun, Dong Soon Lee, and Hee Chan Kim -- Microchip capillary electrophoresis / Elaine T.T. Tay ... [et al.] -- Detection of enteropathogenic Escherichia Coli by microship capillary electrophoresis / Wai S. Law, Sam F.Y. Li, and Larry J. Kricka.
  • Microchip electrophoresis for DNA separation by wire-imprinted microchannels on PMMA substrates / Shu-Hui Chen -- Fabrication of porous polymer monoliths in microfluidic chips for selective nucleic acid concentration and purification / Jay A.A. West and Brent C. Satterfield -- Rapid electrical lysis of bacterial cells in a microfluidic device / Hsiang-Yu Wang ... [et al.] -- On-chip bioassay using immobilized sensing bacteria in three-dimensional microfluidic network / Hirofumi Tani, Koji Maehana, and Tamio Kamidate -- Microchip-based enumeration of human white blood cells / Pierre Floriano ... [et al.] -- Microchip for the diagnosis of cervical cancer / Anja Gulliksen and Frank Karlsen -- DNA microchips toward molecular signatures in cervical cancers / Yick F. Wong ... [et al.] -- Impedimetric detection for DNA hybridization within microfluidic biochips / Louise Lingerfelt ... [et al.] -- Applications of functional protein microarrays: identifying protein/protein interactions in an array format / Matthew A. Coleman ... [et al.] -- A microchip-based assay for interleukin-6 / Nicolaos Christodoulides ... [et al.] -- Allergen microarrays for the diagnosis of specific IgE against components of cow milk and hen egg in a multiplex biochip-based immunoassay / Christian Harwanegg, Sabine Hutter, and Reinhard Hiller -- Surface plasmon resonance imaging on polypyrrole protein chips: application to streptavidin immobilization and immunodetection / Emilie Mercey ... [et al.] -- Protein array-based multiplexed cytokine assays / Cheng C. Wang -- Lectin microarrays for glycoprotein analysis / Lara K. Mahal and Kanoelani Pilobello -- Interaction of HIV RNA with peptides detected by acoustic shear wave sensor operated in an on-line format / Anil Deisingh ... [et al.] -- Microchip-based electrochemical enzyme immunoassays / Madhu Prakash Chatrathi, Greg Collins, and Joseph Wang.
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    v. 1. Blood-vessel interactions -- v. 2. Microcirculation.
  • This book presents a new method for analyzing the structure and function of the biological branching systems of fractal trees, with a focus on microcirculation. Branching systems in humans (vascular and bronchial trees) and those in the natural world (plants, trees, and rivers) are characterized by a fractal nature. To date, fractal studies have tended to concentrate on fractal dimensions, which quantify the complexity of objects, but the applications for practical use have remained largely unexplored. This book breaks new ground with topics that include the human retinal microcirculatory network, oxygen consumption by vascular walls, the Fh raeus-Lindqvist effect, the bifurcation exponent, and the asymmetrical microvascular network. Readers are provided with simple formulas to express functions and a simulation graph with in vivo data. The book also discusses the mechanisms regulating blood flow and pressure and how they are related to pathological changes in the human body. Researchers and clinicians alike will find valuable new insights in these pioneering studies.
  • In vivo target site concentrations are probably the most important determinant of drug effects. Traditionally, linking drug concentrations to drug effects has been accomplished by modelling blood-derived data, mostly because a direct quantification of tissue concentrations has been beyond technical reach. Today, a direct measurement of target site concentrations is possible by employing microdialysis or complementary approaches such as imaging technologies. Microdialysis, initially conceived in the 1970s, has become a standard tool in drug development. This comprehensive overview of current microdialysis technology covers general and disease-specific aspects of microdialysis by international experts in the field. It provides useful information for colleagues in academia and industry who are interested PK-PD aspects of drug development.
  • Microdrop generation 2003
  • Machine generated contents note: 1 Introduction -- Modeling and Simulation Issues -- Modeling and Simulation Needs -- Computational Architectures for MEFS -- Hierarchical Modeling and Simulation -- Advanced Hierarchical Design Methodology -- Hierarchical Design and Simulation Optimization -- System Design Language Uniformity -- Overview -- 2 Hierarchical Modeling -- MEFS Dynamic Modeling and Simulation at Circuit Level -- Classification of Dynamic System Models -- Fundamental Variables -- Relationships between Fundamental Variables -- Kirchhoffian Networks -- The Equivalent Circuit Modeling Method -- MEFS System-level Modeling and Simulation -- MEFS System-level Modeling -- MEFS System-level Simulation -- Statistical Analysis Capacity -- Conclusion -- 3 SystemC-based Hierarchical Design Environment -- Suitability of Modeling Languages for Hierarchical Design -- VHDL-AMS Suitability for Circuit-level Modeling and Sim- -- ulation -- VHDL Suitability for System-level Modeling and Simula- -- tion -- Performance Language-SLAM -- C/C++ and Matlab -- SystemC -- Building Design Environment with SystemC -- Hierarchical Design Environment -- System-level Modeling Package -- Circuit-level Component Modeling Package -- Numerical Simulation Package -- Optimization/Verification Package -- Conclusion -- 4 System-level Simulation and Performance Evaluation -- MEFS Computing and Architecture -- Architectural Concepts -- Architecture Proposal -- Reconfigurable Architectural Functional Requirements -- Potential Architecture -- Performance Modeling and Simulation -- Hierarchical Modeling and Simulation Methodology -- MEFS Hierarchical Perspective -- Hierarchical Performance Evaluation Strategy -- Modeling and Simulation Language -- Micro-Chemical Handling System -- Stochastic Performance Modeling -- Thermal Catalyzing Process Functionality -- Microvalve Lumped-element Nodal Modeling -- System Performance Analysis and Design Optimization -- Architectural Optimization -- Microsystem Performance Sensitivity Analysis -- Microsystem Performance Estimation with Traffic Variation -- Conclusion -- 5 Circuit-level Optimization -- Simulation Design Methodology -- Bootstrap Method -- Factorial Design -- Optimization Verification -- Subjective Verification -- Objective Verification -- On-target Design Optimization -- Statistical Modeling and Response Analyses -- Statistical Modeling of a Microvalve -- Search for On-target Design Point -- Sensitivity Analysis -- Robust Design Optimization -- Statistical Response Analysis -- Statistical Response Analysis of Microresonators -- Design Optimization of Microvalves -- Application Flexibility Optimization -- Design Approach -- Determining the Performance Flexibility -- Optimization Procedure -- Case Study: Microvalve Modeling and Optimal Design -- Conclusion -- 6 Performance Evaluation -- Introduction -- Polymerase Chain Reaction (PCR) -- PCR Detection for DNA Concentration -- PCR Purification -- Acquisition Assumption -- Continuous-flow PCR System -- Three-way Microvalve -- Sequential Continuous-flow PCR System -- Detectable PCR System -- Reconfigurable PCR System -- Droplet-based PCR System -- A Droplet-based PCR System -- Physical Implementation -- Comparison between Continuous-flow PCR and Droplet PCR -- System Design Complexity -- Performance Evaluation -- Scheduling of Microfluidic Operations for Reconfigurable Two-Dimensional -- Electrowetting Arrays -- Introduction -- Two-dimensional Electrowetting Array -- Schedule Optimization -- Droplet-based PCR Systems -- 7 Conclusion -- A VHDL Queuing Model -- B Hierarchical Environment with SystemC -- References -- Index.
  • Overview of advances in microfluidics and microfabrication / Shelley D. Minteer and Christine M. Moore -- Introduction to microfabrication techniques / Rabih Zaouk, Benjamin Y. Park, and Marc J. Madou -- Fabrication ofpolydimethylsiloxane microfluidics using SU-8 molds / Rabih Zaouk, Benjamin Y. Park, and Marc J. Madou -- Fabrication of microelectrodes using the lift-off technique / Benjamin Y. Park, Rabih Zaouk, and Marc J. Madou -- Laser ablation as a fabrication technique for microfluidic devices / Emanual A. Waddell -- Reversible, room temperature bonding of glass devices for microfluidics / Loranelle L. Lockyear -- Solid phase extraction in packed beds on glass microdevices / Loranelle L. Lockyear -- Fabrication of micromachined magnetic particle separators for bioseparation in microfluidic systems / Jin-Woo Choi -- Hydrogel-immobilized antibodies for microfluidic immunoassays: hydrogel immunoassay / Gloria Thomas ... [et al.] -- Polymerase chain reaction in miniaturized systems : big progress in little devices / Kalee D. Spitzack and Victor M. Ugaz -- Polymerase chain reaction on microchips / Maria C. Carles and Nikolaus J. Sucher -- A sensitive sandwich DNA array using fluorescent nanoparticle probes / Xiajun Zhao, David T. Pierce, and Yanfu Huan -- Microfluidic ethanol biobatteries on a microchip / Shelley D. Minteer and Christine M. Moore -- Microfluidic chambers for cell migration and neuroscience research / Anne M. Taylor, Seog Woo Rhee, and Noo Li Jeon -- Microtextured polydimethylsiloxane substrates for culturing mesenchymal stem cells / Erik T.K. Peterson and Ian Papautsky -- Contraction study of a single cardiac muscle cell in the microfluidic chip / Xiujun (James) Li and Paul C.H. Li -- Microscale inegrated sperm sorter / Yaokuang Chung ... [et al.].
  • Microglia methods and protocols 2013
    Springer Protocols
    Part I Overview of microglia biology -- Brief overview of multitalented microglia / Bertrand Joseph and José Luis Venero -- Part II Isolation and culture of microglia -- Cell culturing of human and murine microglia cell lines / Johanna Rodhe -- Microglia isolation from adult mouse brain / Jae-Kyung Lee and Malú G. Tansey -- Preparation of primary microglia cultures from postnatal mouse and rat brains / Tomas Deierborg -- Isolation of murine postnatal brain microglia for phenotypic characterization using magnetic cell separation technology / Ashley S. Harms and Malú G. Tansey -- Isolation and culture of adult human microglia within mixed glial cultures for functional experimentation and high-content analysis / Amy M. Smith ... [et al.] -- Part III Depletion and transduction of microglia -- Depletion of microglia from primary cellular cultures / Lorena Pont-Lezica, Sabrina Colasse, and Alain Bessis -- Lentiviral transduction of cultured microglia / Takahiro Masuda ... [et al.] -- Part IV Analysis of microglial cytokine production -- Microglial activation : measurement of cytokines by flow cytometry / Deepak Kumar Kaushik and Anirban Basu -- In situ hybridization of cytokine mRNA using alkaline phosphatase-labelled oligodeoxynucleotide probes / Bettina Clausen, Christina Fenger, and Bente Finsen -- Use of meso-scale discovery to examine cytokine content in microglia cell supernatant / Miguel A. Burguillos -- Part V Analysis of microglia activation -- Analysis of microglial production of reactive oxygen and nitrogen species / Urte Neniskyte and Guy C. Brown -- Quantification of active caspase-3 and active caspase-8 in microglia cells / Edel Kavanagh -- Quantification of microglial phagocytosis by a flow cytometer-based assay / Refik Pul, Kandiyil Prajeeth Chittappen, and Martin Stangel -- Quantification of microglial proliferation and apoptosis by flow cytometry / Alicia A. Babcock, Martin Wirenfeldt, and Bente Finsen -- Fluorescence imaging of intracellular Ca2+, Na+, and H+ in cultured microglia / Tom Schilling and Claudia Eder -- Patch clamp protocols to study ion channel activity in microglia / Tom Schilling and Claudia Eder -- Part VI Analysis of microglia polarization -- Studying M1 and M2 states in adult microglia / Sadanand M. Gaikwad and Michael T. Heneka -- Isolating, culturing, and polarizing primary human adult and fetal microglia / Bryce A. Durafourt ... [et al.] -- Part VII Co-culture systems to analysis microglia interactions with other cell types -- Understanding microglia-neuron cross talk : relevance of the microglia-neuron cocultures / Fernando G. Correa, Miriam Hernangómez, and Carmen Guaza -- Preparation of rodent primary cultures for neuron-glia, mixed glia, enriched microglia, and reconstituted cultures with microglia / Shih-Heng Chen, Esteban A. Oyarzabal, and Jau-Shyong Hong -- Part VIII Analysis of microglia functions in vivo -- Microglia detection by enzymatic histochemistry / Beatriz Almolda, Berta González, and Bernardo Castellano -- Tomato lectin histochemistry for microglial visualization / Nàdia Villacampa ... [et al.] -- Immunohistochemical detection of microglia / Rocío M. de Pablos, Ana M. Espinosa-Oliva, and Antonio J. Herrera -- Intrathecal Infusion of Microglia Cells / Takahiro Masuda ... [et al.] -- Intracranial injection of LPS in rat as animal model of neuroinflammation / Ana M. Espinosa-Oliva, Rocío M. de Pablos, and Antonio J. Herrera -- Analyses of microglia effector function using CX3CR1-GFP knock-in mice / Jenny A. Garcia, Sandra M. Cardona, and Astrid E. Cardona -- In vivo two-photon microscopy of microglia / Satoru Kondo and Shigeo Okabe -- Use of confocal microscopy in the study of microglia in a brain metastasis model / Manuel Sarmiento.
  • 1. Introduction -- 2. Long Duration Flight Data -- 3. Earthbound and Microgravity Pathophysiology of Increased Intracranial Pressure -- 4. Papilledema and Microgravity-Induced Fluid Shift -- 5. The Role of Carbon Dioxide and Exercise -- 6. Diet and Personalized Medicine -- 7. Future Research -- Glossary -- Index.
  • Expression of exogenous mRNA in Xenopus laevis embryos for the study of cell cycle regulation / Jill C. Sible and Brian N. Wroble -- Use of luciferase chimaera to monitor PLC[zeta] expression in mouse eggs / Karl Swann ... [et al.] -- Analysis of 14-3-3 family member function in Xenopus embryos by microinjection of antisense morpholino oligos / Jeffrey M.S. Lau and Anthony J. Muslin -- A microinjectable biological system, the Xenopus oocyte, as an approach to understanding signal transduction protein function / Katia Cailliau and Edith Browaeys-Poly -- Combining microinjection and immunoblotting to analyse MAP kinase phosphorylation in single starfish oocytes and eggs / David J. Carroll and Wei Hua -- Analysis of signaling pathways in zebrafish development by microinjection / William H. Kinsey -- Protein inhibition by microinjection and RNA-mediated interference in tissue culture cells : complementary approaches to study protein function / Jane R. Stout, Rania S. Rizk, and Claire E. Walczak -- DNA delivery by microinjection for the generation of recombinant mammalian cell lines / Sebastien Chenuet ... [et al.] -- Bacteriophage [phi]C31 integrase mediated transgenesis in Xenopus laevis for protein expression at endogenous levels / Bryan G. Allen and Daniel L. Weeks -- Germline transformation of Caenorhabditis elegans by injection / Pavan Kadandale, Indrani Chatterjee, and Andrew Singson -- Quantitative microinjection of mouse oocytes and eggs / Douglas Kline -- Microinjection of follicle-enclosed mouse oocytes / Laurinda A. Jaffe ... [et al.] -- Functional studies of regulatory genes in the sea urchin embryo / Vincenzo Cavalieri, Maria Di Bernardo, and Giovanni Spinelli -- Exploring the cytoskeleton during intracytoplasmic sperm injection in humans / Vanesa Y. Rawe and Héctor Chemes -- Somatic cell nuclear transfer in the mouse / Satoshi Kishigami and Teruhiko Wakayama.
  • Micromammals and macroparasites : who is who and how they interact? / S. Morand ... [et al.] -- Digenean trematodes / C. Feliu ... [et al.] -- Cestodes of small mammals : taxonomy and life cycles / B.B. Georgiev, R.A. Bray and D.T.J. Littlewood -- Nematodes / S. Morand, S. Bouamer and J.-P Hugot -- Acanthocephalans / A. Ribas and J.C. Casanova -- Taxonomy, host associations, life cycles and vectorial importance of ticks parasitizing small mammals / L.A. Durden -- Mesostigmatid mites as parasites of small mammals : systematics, ecology, and the evolution of parasitic associations / A.P.G. Dowling -- Taxonomy, life cycles and the origin of parasitism in trombiculid mites / A.B. Shatrov and J.I. Kudryashova -- Blood-sucking lice (Anoplura) of small mammals : true parasites / K.C. Kim -- Fleas : permanent satellites of small mammals / S.G. Medvedev and B.R. Krasnov -- Bat flies : obligate ectoparasites of bats / C.W. Dick and B.D. Patterson -- Patterns of macroparasite diversity in small mammals / B.R. Krasnov, R. Poulin and S. Morand -- Patterns of host specificity in parasites exploiting small mammals / R. Poulin, B.R. Krasnov and S. Morand -- Coevolution of macroparasites and their small mammalian hosts : cophylogeny and coadaptation / J.-P. Hugot -- Comparative phylogeography : the use of parasites for insights into host history / Cj.M. Nieberding and S. Morand -- Insularity and micromammal-macroparasite relationships / E. Magnanou and S. Morand -- Models for host-macroparasite interactions in micromammals / R. Rosà ... [et al.] -- Transmission ecology and the structure of parasite communities /aI.M. Cattadori ... [et al.] -- Effect of macroparasites on the energy budget of small mammals / A.A. Degen -- Immunogenetics of micromammal-macroparasite interactions / N. Charbonnel, J. Goüy de Bellocq and S. Morand -- Interactions among immune, endocrine, and behavioural response to infection / Z.M. Weil, L.B. Martin II and R.J. Nelson -- Behaviour, life history strategies and parasite infection in rodents / C.J. Barnard and J.M. Behnke -- Nematode zoonoses / J.C. Casanova, A. Ribas and J.M. Segovia -- Rodents as definitive hosts of Schistosoma, with special reference to S. mansoni transmission / J.-M. Duplantier and M. Sene -- Towards understanding the impacts of environmental variation on Echinococcus multilocularis transmission / D.R.J. Pleydell ... [et al.] -- Parasites and pest population management / H. Leirs and G.R. Singleton -- Biological conservation and parasitism / P. Christe, S. Morand and J. Michaux -- Global changes and the future of micromammal-macroparasite interactions / S. Morand, R. Poulin and B.R. Krasnov.
  • ch. 1. From macrooptics to microoptics: an overview, p. 1-12 -- ch. 2. Optical components with small dimensions, p. 13-32 -- ch. 3. Lithographic fabrication technology, p. 33-76 -- ch. 4. Measurement and characterization of microoptics, p. 77-92 -- ch. 5. Refractive microoptics, p. 93-131 -- ch. 6. Diffractive microoptics, p. 133-180 -- ch. 7. Integrated waveguide optics, p. 181-205 -- ch. 8. Microoptical systems, p. 207-228 -- ch. 9. Optoelectronic devices and smart pixel arrays, p. 229-250 -- ch. 10. Array illuminators, p. 251-276 -- ch. 11. Microoptical components for beam shaping, p. 277-303 -- ch. 12. Microoptics for optical information technology, p. 305-336 -- ch. 13. Microoptics in optical design, p. 337-353 -- ch. 14. Novel directions, p. 355-381.
  • Biotechnology and the public health response to bioterrorism -- Historical perspectives of microbial bioterrorism -- The infectious disease physician and microbial bioterrorism -- Modulation of innate immunity to protect against biological weapon threat -- Smallpox: pathogenesis and host immune responses relevant to vaccine and therapeutic strategies -- Bacillus anthracis: agent of bioterror and disease -- Tularemia pathogenesis and immunity -- Brucella and bioterrorism -- Pneumonic plague -- Coxiella burnetii, Q fever, and bioterrorism -- Genomic and proteomic approaches against Q fever -- Rickettsia rickettsii and other members of the spotted fever group as potential bioweapons.
  • Machine generated contents note: ch. 1 Microorganisms in air -- 1.1.Microorganisms in outdoor air / B. Flannigan -- 1.2.Microorganisms in indoor air / B. Flannigan -- 1.3.Pollen in indoor air / A. Rantio-Lehtimaki -- ch. 2 Microorganisms in homes and work environments -- 2.1.Microbial growth in indoor environments / J.D. Miller -- 2.2.Bacteria and other bioaerosols in industrial workplaces / J.R.M. Swan -- 2.3.Remediation and control of microbial growth in problem buildings / P.R. Morey -- ch. 3 Airborne microorganisms and disease -- 3.1.Allergenic microorganisms and hypersensitivity / J.H. Day -- 3.2.Occupational respiratory disease: hypersensitivity pneumonitis and other forms of interstitial lung disease / B. Flannigan -- 3.3.Respiratory tract infections caused by indoor fungi / R.C. Summerbell -- ch. 4 Microbiological investigation of indoor environments -- 4.1.Mycological investigations of indoor environments / J.D. Miller -- 4.2.Molecular methods for bioaerosol characterization / J.A. Scott -- 4.3.Isolation and identification of fungi / J. Houbraken -- 4.4.Analysis of microbial volatile organic compounds / T.J. Ryan -- 4.5.Analysis for toxins and inflammatory compounds / J.D. Miller -- 4.6.Interpreting sampling data in investigations of indoor environments: selected case studies / P.R. Morey -- ch. 5 Common and important species of Actinobacteria and fungi in indoor environments -- Common and important species of fungi and actinomycetes in indoor environments / J.D. Miller -- Descriptions and illustrations of common fungi and actinomycetes.
  • Pt. A ScienceDirect
    Pt. B ScienceDirect
    Pt. C ScienceDirect
    "Micropatterning refers generally to techniques which provide an experimental control over the chemical, physical, or geometrical properties of materials at the micron or submicron scale, and are thus used to produce spatial patterns of these properties. These techniques, which were often originally designed for application in microelectronics, have spread over most areas of science, including biology. They have proved particularly useful for cell biology, bridging the gap between the Petri-dish and complex 3D assays and tissues."--Preface.
  • Microperimetry and Multimodal Retinal Imaging: the Fundamentals: Functional Evaluation of the Retina: an Introduction -- Retinal Fixation and Microperimetry -- Microperimetry: technical remarks -- OCT/SLO Microperimetry and Correlates -- Scotopic microperimetry -- Multimodal retinal imaging: an Introduction. Clinical Applications of Microperimetry and Multimodal Retina Imaging: Early and Intermediate Age-Related Macular Degeneration -- Geographic atrophy -- Neovascular age-related macular degeneration -- Retinal Pigment Epithelium and Choroid Graft -- Macular Telangiectasia Type 2 -- Diabetes and Retinal Vascular Disorders -- Myopia -- Retinal Dystrophies -- Disorders of the vitreoretinal interface -- Inflammatory chorio-retinal diseases -- Toxic retinopathies -- Glaucoma. The contribution to visual rehabilitation: Low vision: diagnosis and rehabilitation.
  • MicroRNA Biogenesis and Cancer / Julia Winter, Sven Diederichs -- Computational Identification of miRNAs Involved in Cancer / Anastasis Oulas, Nestoras Karathanasis, Panayiota Poirazi -- The Principles of MiRNA-Masking Antisense Oligonucleotides Technology / Zhiguo Wang -- The Concept of Multiple-Target Anti-miRNA Antisense Oligonucleotide Technology / Zhiguo Wang -- Modulation of MicroRNAs for Potential Cancer Therapeutics / Wei Wu -- Detection of MicroRNAs in Cultured Cells and Paraffin-Embedded Tissue Specimens by In Situ Hybridization / Ashim Gupta, Yin-Yuan Mo -- MicroRNA Northern Blotting, Precursor Cloning, and Ago2-Improved RNA Interference / Julia Winter, Sven Diederichs -- miRNA Profiling on High-Throughput OpenArray System / Elena V. Grigorenko, Elen Ortenberg, James Hurley, Andrew Bond, Kevin Munnelly -- Silicon Nanowire Biosensor for Ultrasensitive and Label-Free Direct Detection of miRNAs / Guo-Jun Zhang -- High-Throughput and Reliable Protocols for Animal MicroRNA Library Cloning / Caide Xiao -- MicroRNA Regulation of Growth Factor Receptor Signaling in Human Cancer Cells / Keith M. Giles, Andrew Barker, Priscilla M. Zhang, Michael R. Epis, Peter J. Leedman -- Epigenetic Regulation of MicroRNA Expression in Cancer / Hani Choudhry, James W. Catto -- In Vitro Functional Study of miR-126 in Leukemia / Zejuan Li, Jianjun Chen -- Prediction of the Biological Effect of Polymorphisms Within MicroRNA Binding Sites / Debora Landi, Roberto Barale, Federica Gemignani, Stefano Landi -- The Guideline of the Design and Validation of MiRNA Mimics / Zhiguo Wang -- Analysis of Targets and Functions Coregulated by MicroRNAs / Shu-Jen Chen, Hua-Chien Chen -- Utilization of SSCprofiler to Predict a New miRNA Gene / Anastasis Oulas, Panayiota Poirazi -- MicroRNA Profiling Using Fluorescence-Labeled Beads: Data Acquisition and Processing / Thomas Streichert, Benjamin Otto, Ulrich Lehmann.
  • "This book reflects the current state of knowledge about the role of microRNAs in the formation and progression of solid tumours. The main focus lies on computational methods and their applications in combination with cutting edge experimental techniques that are used to approach all aspects of microRNA regulation in cancer. The use of high-throughput quantitative techniques makes an integrative experimental and computational approach necessary. This book will be a resource for researchers starting out with microRNA research, but is also intended for the experienced researcher who wants to incorporate concepts and tools from systems biology and bioinformatics into his work. Bioinformaticians and modellers are provided with a general perspective on microRNA biology, and the state-of-the-art in computational microRNA biology." --Publisher's description.
  • MicroRNA in cancer 2013
    The field of microRNA biology is really emerging in the last couple of years. Several investigators highlighted the importance of miRNAs in cancer. Although there is so much literature on microRNAs exist, a comprehensive book is still not available. Thus this book will be a great use to the scientists in the field of cancer biology. In addition, this book will be a good source of information for undergraduate, graduate students who want to develop their research careers in cancer biology.
  • MicroRNA methods 2007
  • Measurement and interpretation of microRNA expression profiles / Bo Curry and Robert Ach -- MicroRNA expression analysis by LNA enhanced microarrays / Rolf Sokilde ... [et al.] -- Analysis and QC for real-time OPCR arrays of human microRNAs / Dirk P. Ditmer ... [et al.] -- Massively parallel microRNA profiling in the haematologic malignancies / Ryan D. Morin ... [et al.] -- Who dunit? microRNAs involved in prostate cancer / Chang Hee Kim -- Intronic microRNA : creation, evolution and regulation / Sailen Barik and Titus Barik -- miRome architechture and genomic instability / Konrad Huppi ... [et al.] -- Interconnection of microRNA and transcription factor-mediated regulatory networks / Yiming Zhou -- Analysis of microRNA profiling data with systems biology tools / Yuriy Gusev ... [et al.] -- Mathematical and computational modeling of post-transriptional gene regulation by microRNAs / Raya Khanin and Desmond J. Higham.
  • MicroRNA protocols 2006
    Springer Protocols
  • The book serves as a comprehensive resource for scientists and clinicians studying the role of non-coding RNAs in inflammation (viral infections, wound inflammation), human inflammatory diseases (i.e. rheumatoid arthritis, Crohnℓ́ℓs disease, diabetes), and innate immunity. It provides a universal reference work comprising both basic and specialized information. Given that ncRNAs represent new therapeutic targets, this volume will also be of interest to industrial biomedical researchers and those involved in drug development.
  • A rapid, quantitative assay for direct detection of microRNAs and other small RNAs using splinted ligation -- Normalization of microRNA quantitative RT-PCR data in reduced scale experimental designs -- MicroRNA detection in bone marrow cells by LNA-FISH -- Measuring microRNA expression in size-limited facs-sorted and microdissected samples -- MicroRNA cloning from cells of the immune system -- High-throughput profiling in the hematopoietic system -- Construction of small RNA cDNA libraries for deep sequencing -- MicroRNA-profiling in formalin-fixed paraffin-embedded specimens -- Expression of miRNAs in lymphocytes : A review -- Mouse models for miRNA expression: The ROSA26 locus -- Regulation of monocytopoiesis by microRNAs -- MicroRNA activity in B lymphocytes -- Isolation and characterization of microRNAs of human mature erythrocytes -- Stable overexpression of miRNAs in bone marrow-derived murine mast cells using lentiviral expression vectors -- Monitoring microRNA activity and validating microRNA targets by reporter-based approaches -- Lentivirus-mediated antagomir expression -- Solution structure of miRNA:mRNA complex -- MiRNA editing -- Computational prediction of microRNA targets -- Large-scale integration of microRNA and gene expression data for identification of enriched microRNA-mRNA associations in biological systems -- Identification and validation of the cellular targets of virus-encoded microRNAs.
  • "MicroRNAs are small, non-coding RNA molecules that interact with target mRNAs to modulate their translation. They are now recognized as widespread and critical regulators of gene expression in the cell. This book is aimed at both industry- and academic-based researchers in the Biopharmaceutical production space who wish to learn more about these fascinating molecules..."--Page [4] of cover.
  • 1 -- MicroRNAs in Cancer (An Overview) -- 2. The Role of MicroRNAs in Lung Cancer Development, Progression, and Metastasis -- 3. MicroRNAs in Breast Cancer -- 4. MicroRNAs in Colorectal Cancer -- 5. MicroRNAs in Gastric Cancer -- 6. MicroRNAs in Prostate Cancer: A Possible Role as Novel Biomarkers and Therapeutic Targets?- 7. MicroRNAs in Hepatocellular Carcinoma -- 8. MicroRNAs in Cervical Carcinoma -- 9. MicroRNAs in Esophageal Cancer -- 10. MicroRNAs in Bladder Cancer -- 11. MicroRNAs in Lymphoma -- 12. MicroRNAs in Leukemia -- 13. MicroRNAs in Pancreatic Cancer: Potential Interests as Biomarkers and Therapeutic Tools -- 14. MicroRNAs in Epithelial Ovarian Cancer -- 15. MicroRNAs in Brain Tumors -- 16. MicroRNAs and Cancer Stem Cells -- 17. MicroRNAs in Cancer Invasion and Metastasis -- 18. MicroRNAs in Predicting Radiotherapy and Chemotherapy Response -- 19. Role of MicroRNAs in Anti-cancer Drug Resistance -- 20. MicroRNAs and Cancer Metabolism -- 21. MicroRNAs as Blood-based Biomarkers of Cancer -- 22. RNAi-based Approaches to the Treatment of Brain Tumors.
  • In situ detection of microRNAs in animals / Dylan Sweetman -- Detection of microRNAs in plants by in situ hybridisation / Eva Varallyay and Zoltan Havelda -- Detecting sRNAs by northern blotting / Sara Lopez-Gomollon -- Profiling microRNAs by real-time PCR / Nanna Jacobsen, Ditte Andreasen, and Peter Mouritzen -- Detection of small RNAs and microRNAs using deep sequencing technology / Ericka R. Havecker -- Detection of microRNAs in prostate cancer cells by mircoRNA array / Xiaoqing Tang [and others] -- MicroRNA knock down by cholesterol-conjugated antisence oligos in mouse organ culture / Sharon Kredo-Russo and Eran Hornstein -- Protocols for use of homologous recombination gene targeting to produce microRNA mutants in drosophila / Ya-Wen Chen, Ruifen Weng, and Stephen M. Cohen -- Engineering elements for gene silencing : the artificial microRNAs technology / Pablo Andres Manavella and Ignacio Rubio-Somoza -- Mimicry technology : suppressing small RNA activity in plants / Ignacio Rubio-Somoza and Pablo Andres Manavella -- Experimental validation of microRNA targets using a luciferase reporter system / Francisco E. Nicolas -- Experimental identification of microRNA targets by immunoprecipitation of argonaute protein complexes / Michaela Beitzinger and Gunter Meister -- Comprehensive identification of miRNA target sites in live animals / Dimitrios G. Zisoulis, Gene W. Yeo, and Amy E. Pasquinelli -- Target validation of plant microRNAs / Cesar Llave [and others] -- High-throughput sequencing-based methodology to identify all uncapped and cleaved RNA molecules in eukaryotic genomes / Matthew W. Endres, Rebecca T. Cook, and Brian D. Gregory.
  • Microsatellites or simple sequence repeats (SSRs) have become the markers of choice for a variety of molecular studies because of their versatility, operational flexibility, and lower cost than other marker systems. Microsatellites: Methods and Protocols brings together experts in the field to cover this significant area of research. Broken in to four convenient parts, this volume delves into classical and modern methods for the discovery and development of microsatellite markers, descriptions of amplification and visualization of SSRs, automated capillary sequencers that are widely used for fragment analysis, as well as a variety of methods for the analysis of data obtained by the use of microsatellites. Written for the highly successful Methods in Molecular Biology series, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and invaluable, Microsatellites: Methods and Protocols aims at researchers that need detailed protocols for incorporating microsatellite markers into their projects and expert scientists looking to expand their knowledge of SSRs discovery, use, and analysis.
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    "This book elucidates the development of the surgical therapy of ear diseases from antiquity to the middle ages and modern times up to the present."--Preface.
  • ch. 1. Light Microscopy, p. 1-145 -- ch. 2. Electron Microscopy, p. 147-286 -- ch. 3. Other Microscopical Methods and their Application Potential, p. 287-319.
  • Getting Excel data into Access -- Analyzing Excel data with Access queries -- Sprucing up Excel data with Access reports -- Using PivotTables and PivotCharts in Access -- Getting Access data into Excel -- Leveraging macros in Excel and Access -- VBA fundamentals -- Using VBA to move data between Excel and Access -- Exploring Excel and Access automation -- Integrating Excel and Access with XML -- Integrating Excel and other Office applications.
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  • 1. Understanding Microsoft Access -- 2. Building an Access 2007 Desktop Application -- 3. Creating Forms and Reports in a Desktop Application -- 4. Automating an Access Application -- 5. Linking Access and the Web -- 6. After Completing Your Application -- 7. Designing an Access Project -- 8. Articles.
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  • Microsoft Office home and student 2007 step by step 2008
    books24x7, SUNet ID login required.
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    PART 1: WORD 2007: STARTING YOUR DOCUMENT WITH LATEST AND GREATEST: Room to create with Office Word 2007 -- Document creation with Word 2007 -- Mastering page setup and pagination -- Formatting documents using templates -- Applying themes for a professional look -- PART 2: WORKING WITH CONTENT: Mastering document fundamentals -- Honing document navigation skills -- Working with building blocks and other text tools -- Refining with research services and reference tools -- Outlining documents for clarity and structure -- PART 3: VISUAL ELEMENTS: TABLES, CHARTS, DIAGRAMS, PICTURES: Organizing concepts in tables -- Showcasing data with SmartArt and charts -- Adding visual impact with pictures, drawings, and WordArt -- PART 4: PROFESSIONAL POLISH: LISTS, STYLES, BACKGROUNDS, AND BORDERS: Aligning information and formatting paragraphs and lists -- Using styles to increase your formatting power -- Formatting layouts using backgrounds, watermarks, and text boxes -- Commanding attention with borders and shading -- PART 5: COLLABORATIVE PROJECTS: SHARED DOCUMENTS, REVISIONS, SECURITY: Sharing documents and collaborating online -- Revising documents using markup tools -- Addressing document protection and security issues -- PART 6: COMPLEX DOCUMENTS: SECTIONS, MASTER DOCUMENTS, AND REFERENCES: Formatting columns and sections for advanced text content -- Configuring references -- Generating first-class tables of contents and reference tables -- Creating effective indexes -- PART 7: PUBLISHING WORD TO THE WORLD: Printing with precision -- Blogging from Word 2007 -- Performing mail merges -- Customizing documents with content controls -- Working with XML -- Working with macros and VBA.
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  • Microsoft Outlook 2007 bible 2007
    ProQuest Safari
    2007 books24x7, SUNet ID login required.
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  • Microsoft Project 2007 bible 2007
    books24x7, SUNet ID login required.
    2007 ProQuest Safari
  • Microsoft Word 2007 bible 2007
    ProQuest Safari
    2007 books24x7, SUNet ID login required.
  • 1. Microspheres for enzyme immobilization / Fei Gao, Yuxia Wang, and Guanghui Ma -- 2. Microspheres for cell culture / Weiqing Zhou, Guanghui Ma, and Zhiguo Su -- 3. Microcapsules for cell transplantation : design, preparation, and application / Guojun Lv, Ying Zhang, Mingqian Tan, Hongguo Xie, and Xiaojun Ma -- 4. Microspheres for the separation and refolding of proteins with an emphasis on particles made of agarose / Jan-Christer Janson -- 5. Microspheres for separation of bioactive small molecules / Fangling Gong, Guifeng Zhang, and Zhiguo Su -- 6. Microspheres for separation of PEG-modified biomolecules / Yongdong Huang, Yanqin Zhai, and Zhiguo Su -- 7. Microspheres for solid-phase organic synthesis / Jing Zhang and Zhiguo Su -- 8. Microspheres for solid-phase modification of proteins / Tao Hu and Zhiguo Su -- 9. Microspheres and microcapsules for protein drug delivery / Lianyan Wang, Tingyuan Yang, and Guanghui Ma -- 10. Micro/nanospheres for gene drug delivery / Jie Wu and Guanghui Ma -- 11. Microspheres for targeting delivery of anticancer drugs / Wei Wei, Zhanguo Yue, Hua Yue, and Guanghui Ma -- 12. Microspheres for targeting delivery to brain / Chen Jiang, Xinguo Jiang, Yang Liu, Kun Shao, and Rongqin Huang -- 13. Nano/microspheres in bioimaging and medical diagnosis / Xiaohui Li and Chunying Chen -- 14. Affinity nanoparticles for detection / Haruma Kawaguchi and Hiroshi Handa.
  • Guy N. Elston, Laurence J. Garey: The cytoarchitectonic map of Korbinian Brodmann: Arealisation and circuit specialization -- Lazaros C. Triarhou: The cytoarchitectonic map of Constantin von Economo and Georg N. Koskinas -- Rudolf Nieuwenhuys: The myeloarchitectonic studies on the human cerebral cortex of the Vogt -- Vogt school, and their significance for the interpretation of functional neuroimaging data -- Bruce Fischl: Estimating the location of Brodmann Areas from cortical folding patterns using histology and ex vivo MRI -- Simon B. Eickhoff, Danilo Bzdok: Database-driven identification of functional modules in the cerebral cortex -- Robert Turner: Where matters: New approaches to brain analysis -- Robert Turner: MRI methods for in-vivo cortical parcellation -- Nicholas A. Bock, Afonso C. Silva: Visualizing myeloarchitecture in vivo with magnetic resonance imaging in common marmosets (Callithrix jacchus) -- Stefan Geyer: High-field magnetic resonance mapping of the border between primary motor (area 4) and somatosensory (area 3a) cortex in ex-vivo and in-vivo human brains.
  • Microsurgery applied to neurosurgery 2007
    Thieme eNeurosurgery
  • Male Infertility Microsurgical Training / Philip S. Li, Ranjith Ramasamy and Marc Goldstein -- Microsurgery Training: What Should a Resident Know? Should All Microsurgeons be Fellowship Trained? / Ethan Grober and Peter N. Kolettis -- Microsurgical Subinguinal Varix Ligation: Techniques and Technical Pearls / Joshua A. Bodie and Jay I. Sandlow -- Vasovasostomy Techniques for Microsurgery Specialists / Kalen Rimar, Landon Trost and Robert E. Brannigan -- Epididymovasostomy: Tips and Tricks of the Trade / James F. Smith and Ajay K. Nangia -- Sperm Retrieval Techniques in Obstructive Azoospermia: MESA, PESA, and TESA / Anand Shridharani and Jay I. Sandlow -- Microsurgical Testicular Sperm Extraction: Technical Considerations / Peter N. Schlegel -- Noninfertility Scrotal Microsurgery / Akanksha Mehta and Marc Goldstein -- Testis-Sparing Surgery for Testicular Masses / Oleksandr Stakhovskyi and Michael A. S. Jewett -- Robotic Microsurgery for Male Infertility / Sijo J. Parekattil, Ahmet Gudeloglu and Jamin V. Brahmbhatt -- The Role of Microsurgical Reconstruction in the Era of ICSI / Karen Baker and Edmund Sabanegh Jr -- Tubal Microsurgery / Jeffrey M. Goldberg and Tommaso Falcone -- Microsurgical Penile Revascularization, Replantation, and Reconstruction / Jeffrey Lee Rosenblum and Arthur L. Burnett.
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  • This book provides the anatomy of the posterior fossa, together with the main associated surgical techniques, which are detailed in numerous photographs and step-by-step color illustrations. The text presents approaches and surgical techniques such as the trans-cerebellomedullary fissure approach and its variation to the fourth ventricle, as well as the cerebellomedullary cistern, infratentorial lateral supracerebellar approach to the fifth cranial nerve in the upper cerebellopontine angle, infrafloccular approach to the root exit zone of the seventh cranial nerve, transcondylar fossa approach through the lateral part of the foramen magnum, and the stitched sling retraction technique utilized during microvascular decompression procedures for trigeminal neuralgia and hemifacial spasm. It also describes in detail the bridging veins of the posterior fossa, especially the petrosal vein, and bridging veins to the tentorial sinuses, which can block approaches to the affected area. The original Japanese version of this work was published 8 years ago, and has established itself as a trusted guide, especially among young neurosurgeons who need to study various surgical approaches and techniques. In the course of being translated into English, some sections have been revised and new information has been added. The author hopes that the book will help neurosurgeons around the world perform safer operations with confidence.
  • This compact book provides step-by-step guidance in the approaches and techniques developed and currently used at the authorsℓ́ℓ center in D©ơsseldorf for the treatment of a variety of aneurysms. All of the described procedures are minimally invasive and of proven efficacy. In order to assist the reader in fully comprehending all aspects of the techniques, they are illustrated through clear graphics instead of complex photos and radiologic imaging. While the rapid development of endovascular treatment means that it is no longer necessary to employ microsurgery for difficult and hidden aneurysms, proficiency in microsurgery remains essential. For example, full mastery of microsurgical techniques is vital in order to treat middle cerebral and peripheral aneurysms efficiently and with minimal trauma. Minimal invasiveness and optimal cosmetic results have become critically important in enabling the microsurgical method to compete with the endovascular method.℗ℓ In documenting ℓ́ℓtried and testedℓ́ℓ procedures, this book will be invaluable for both established neurosurgeons and residents in neurosurgery.
  • "Remarkable progress in the development of new concepts and techniques used in reconstructive surgery of microtia/atresia of the external auditory canal (EAC) has been made since the beginning of the 21st century. Helical computed tomography has made a three-dimensional reconstruction of the soft tissue of the temporal bone surface and the cranium possible, and has laid the groundwork for a collaboration between plastic surgeons and otologists. This book presents the latest findings on reconstructive surgery performed jointly by plastic surgeons and otologists. Based on this concept, information on diagnosis, surgical procedures, outcomes, long-term results and psychology is discussed. Collaborative surgery offers advantages not only in terms of a better reconstruction of morphology and function, but also in terms of the lower number of surgical procedures required which reduces the psychological pressure and economic burden on patients."--Publisher's website.
  • Microtubule protocols 2007
    Springer Protocols
  • Site-specific fluorescent labeling of tubulin / Kamalika Muhkerjee, Susan L. Bane -- Measuring microtubule persistence length using a microtubule gliding assay / Douglas S. Martin -- Structural studies of the doublecortin family of MAPs / Frank Fourniol, Mylène Perderiset, Anne Houdusse, Carolyn Moores -- Detection and quantification of microtubule detachment from centrosomes and spindle poles / Anutosh Ganguly, Hailing Yang, Fernando Cabral -- Regulation of tubulin expression by micro-RNAs : implications for drug resistance / Sharon Lobert, Mary E. Graichen -- Determining the structure-mechanics relationships of dense microtubule networks with confocal microscopy and magnetic tweezers-based microrheology / Yali Yang, Megan T. Valentine -- Studying mitochondria and microtubule localization and dynamics in standardized cell shapes / Andrea Pelikan, James Sillibourne, Stephanie Miserey-Lenkei, Frederique Carlier-Grynkorn, Bruno Goud, Phong T. Tran -- Going solo : measuring the motions of microtubules with an in vitro assay for TIRF microscopy / Kris Leslie, Niels Galjart -- Analysis of microtubules in isolated axoplasm from the squid giant axon / Yuyu Song, Scott T. Brady -- Imaging GTP-bound tubulin : from cellular to in vitro assembled microtubules / Hélène de Forges, Antoine Pilon, Christian Poüs, Franck Perez -- Tubulin-specific chaperones : components of a molecular machine that assembles the ... heterodimer / Guoling Tian, Nicholas J. Cowan -- Heterotrimeric G proteins and microtubules / Witchuda Saengsawang, Mark M. Rasenick -- Purification and biophysical analysis of microtubule-severing enzymes in vitro / Juan Daniel Diaz-Valencia, Megan Bailey, Jennifer L. Ross -- Measurement of in vitro microtubule polymerization by turbidity and fluorescence / Matthew Mirigian, Kamalika Mukherjee, Susan L. Bane, Dan L. Sackett -- Live-cell imaging of microtubules and microtubule-associated proteins in arabidopsis thaliana / Jessica Lucas -- Investigating tubulin posttranslational modifications with specific antibodies / Maria M. Magiera, Carsten Janke -- Purification and assembly of bacterial tubulin BtubA/B and constructs bearing eukaryotic tubulin sequences / José M. Andreu, María A. Oliva -- Microtubule-associated proteins and tubulin interaction by isothermal titration calorimetry / P.O. Tsvetkov, P. Barbier, G. Breuzard, V. Peyrot, F. Devred -- Methods for studying microtubule binding site interactions : zampanolide as a covalent binding agent / Jessica J. Field, Enrique Calvo, Peter T. Northcote, John H. Miller, Karl-Heinz Altmann, José Fernando Díaz -- Studying kinetochore-fiber ultrastructure using correlative light-electron microscopy / Daniel G. Booth, Liam P. Cheeseman, Ian A. Prior, Stephen J. Royle -- Fluorescence-based assays for microtubule architecture / Susanne Bechstedt, Gary L. Brouhard -- Structure-function analysis of yeast tubulin / Anna Luchniak, Yusuke Fukuda, Mohan L. Gupta -- Using MTBindingSim as a tool for experimental planning and interpretation / Julia T. Philip, Aranda R. Duan, Emily O. Alberico, Holly V. Goodson -- Imaging individual spindle microtubule dynamics in fission yeast / Judite Costa, Chuanhai Fu, Viktoriya Syrovatkina, Phong T. Tran.
  • Microwave ablation is a simple, affordable, and highly precise technique. After its successful application in treating liver tumors, it is now widely used to combat renal tumors, adrenal tumors, thyroid nodes, uterine fibroids and other solid tumors. This book presents 40 successful cases of treating these diseases. A series of picture before treatment, after treatment and from different angles is provided for each kind of tumor treatment. In each chapter, step by step operative techniques and illustrations are included. This book also examines CT, NMR and ultrasonography to evaluate the effect of microwave ablation. Editor Ping Liang, is the Director and Professor at Dept. of Interventional Ultrasound, General Hospital of PLA, Beijing, China. Editor Xiaoling Yu is Professor and Chief physician, Editor Jie Yu is Associate Chief physician at the same department.
  • The middle ear plays a vital role in the sense and sensitivity of hearing. Of the various characteristics that distinguish mammals from other vertebrates, several pertain specifically to the middle-ear system, such as the presence of three middle-ear bones and the four-layer composite structure of the tympanic membrane. The Middle Ear attempts to elucidate the role this system plays in sound transmission, as viewed from both scientific and clinical perspectives.
  • Middle ear surgery 2006
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  • Midface surgery 2009
    Anatomy of the upper and lower eyelids -- Anchoring technique for browlifting -- Correction of upper lid ptosis -- Correction of the tear through deformity with hyaluronic acid -- Lower lid blepharoplasty with fat grafts for correction of the tear though -- No-touch lower blepharoplasty -- Alloplastic augmentation to improve blepharoplasty and midfacial results -- Orbital aging and harmony in orbital rejuvenation -- Evolution of the subperiosteal midface lift -- Midface elevation: one single suture -- Is the transpalpebral approach to the upper and midface rejuvenation a safe method? -- A personal approach to upper and lower blepharoplasty -- Transconjuctival deep-plane midface rejuvenation -- Correction of blepharoplasty complications, management of the elevated upper eylid during blepharoplasty -- Atypical granulomas and infection after blepharoplasty -- Autogenous allogeneic and alloplastic lower lid spacers after blepharoplasty
  • pt. 1. GENERAL ASPECTS OF MIDKINE -- General Information on Midkine / Takashi Muramatsu -- The Role of Midkine in Neural Development and Patterning / Sheng Yao and Christoph Winkler -- Midkine: A Player in Innate Immunity / Sara L. Nordin and Arne Egesten -- Midkine/P63 Axis in Regulation of Epithelial-Mesenchymal Transition / Yiping Huang and Edward A. Ratovitski -- Immunochemical Methods for the Detection of Midkine in Samples of Human Origin / Stefan Sommerschuh, Michael Kirchner and Nicole Gliese -- Circulating Midkine in Malignant, Inflammatory, and Infectious Diseases: A Systematic Review / Malgorzata Krzystek-Korpacka and Malgorzata Matusiewicz -- pt. 2. MIDKINE AND INFLAMMATION -- Midkine in Inflammation and Inflammatory Diseases / Nuray Yazıhan, Mehtap Kacar Kocak and Ethem Akcıl -- Rheumatoid Arthritis and Midkine / Hisako Muramatsu, Kiyoko Maruyama and Naoki Ishiguro -- pt. 3. MIDKINE AND THE CARDIOVASCULAR SYSTEM -- Midkine and Heart Failure / Mitsuru Horiba and Kenji Kadomatsu -- Vascular Restenosis and Midkine / Kenji Kadomatsu -- The Potential of MK Through the Renin-Angiotensin System / Tomoki Kosugi and Kenji Kadomatsu -- pt. 4. MIDKINE AND THE NERVOUS SYSTEM -- Midkine and Multiple Sclerosis / Hideyuki Takeuchi -- Midkine Gene Transfer in Brain Infarction / Hiroaki Ooboshi, Eiichi Ishikawa, Junichi Takada, Takashi Shichita and Yasuhiro Kumai -- Midkine in Psychiatric and Neurodegenerative Diseases / Eiji Shimizu and Daisuke Matsuzawa -- pt. 5. MIDKINE AND THE UROGENITAL SYSTEM, REPRODUCTION AND AGING -- Role of Midkine in Nephrogenesis and Kidney Disease / Waichi Sato and Kenji Kadomatsu -- Midkine, a Factor Promoting Cytoplasmic Maturation of Oocytes / Masayasu Yamada, Yuuki Isaji and Shuntaro Ikeda -- Endometriosis May Be Promoted by Midkine: Possible Involvement of Ovarian Follicles / Yutaka Osuga, Yasushi Hirota, Kaori Koga, Osamu Yoshino and Tetsuya Hirata -- Stem Cells and Midkine / Hisako Muramatsu, Peng Zou and Takashi Muramatsu -- Midkine in Skeletal Physiology / Astrid Liedert, Thorsten Schinke, Anita Ignatius and Michael Amling -- pt. 6. MIDKINE AND CANCER -- Midkine and Chemoresistance in Cancers / Yoshifumi Takei and Kenji Kadomatsu -- A Gene Medicine with the Midkine-mediated Transcriptional Regulation as New Cancer Therapeutics / Masatoshi Tagawa, Kiyoko Kawamura, Ling Yu, Yuji Tada and Kenzo Hiroshima, et al. -- Midkine as a Tumor-Shared Antigen / Jerome Kerzerho, Florence Anne Castelli and Bernard Maillère -- Midkine in Prostate Cancer / Zongbing You -- Midkine Is a Potential Therapeutic Target of Hepatocellular Carcinoma / Li Cheng Dai, Xing Yao and Jing Zhong -- Midkine in Glioblastoma with the Modulator Role Switching Autophagy to Cell Death or Cell Survival / Mine Ergüven and Ayhan Bilir -- Colon Cancer and Midkine / Özgür Kemik, Ahu Sarbay Kemik and A. Cumhur Dülger -- Osteosarcoma and Midkine / Tadashi Kaname, Kumiko Yanagi and Hiroki Maehara.
  • General approach to psoriasis treatment / Laura F. Sandoval and Steven R. Feldman -- General guidelines for administration of topical agents / Shannon Famenini, Eric Y. Sako, and Jashin Wu -- Topical corticosteroids / Laura F. Sandoval and Steven R. Feldman -- Vitamin D3 analogs / Argentina Leon, Chai Sue Lee, and John Y.M. Koo -- Fixed dose corticosteroid/calcipotriene combination therapy / Ethan Levin and John Y.M. Koo -- Tazarotene / Monica Huynh, Chai Sue Lee, and John Y.M. Koo -- Topical calcineurin inhibitors / Mark G. Lebwohl and Chrystal A. Landry -- Coal tar, anthralin, salicyclic acid, and lactic acid / Sarah Fitzmaurice and John Y.M. Koo -- Topical sequential therapy / Rishu Gupta and John Y.M. Koo -- Phototherapy and laser / Mio Nakamura, Holly A. Kerr, and Iltefat Hamzavi -- Combination therapy / Maya G. Debbaneh and Alice Gottlieb -- Palmoplantar psoriasis / Daniel C. Butler and April Armstrong -- Scalp psoriasis / Peter C.M. van de Kerkhof, Marloes M. Kleinpenning, and Rianne M.J.P. Gierritsen -- Inverse psoriasis / Lara Wine-Lee, Robert A. Lee, and Abby S. Van Voorhees -- Psoriasis of the nails / Ashley A. Keyes, Richard K. Scher, Gabrielle B. Poindexter, Maithily A. Nendedkar-Thomas.
  • The role of milk during the life cycle - a global view
  • 1. Milk, nutrition and human health / A. J. Rugg-Gunn and P. E. Petersen -- 2. Clinical studies / J. Bánóczy and A.J. Rugg-Gunn -- 3. Basic science studies / W. M. Edgar -- 4. The addition of fluoride to milk / A. E. Villa -- 5. The Implementation of community based programmes / S. M. Woodward -- 6. Evaluating fluoride exposure in milk fluoridation programmes / A. E. Villa -- 7. Programme evaluation / P. E. Petersen and A. J. Rugg-Gunn -- 8. Conclusions
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  • Using a clinically relevant, systems-based approach, this medical textbook accessibly explains the microbiology of the agents that cause diseases and the diseases that affect individual organ systems. With lavish illustrations and straightforward, accessible explanations, Richard Goering makes this complex subject simple to understand and remember. 150 multiple choice review questions. "Pathogen Parade" and many other features to enhance learning and retention. Enhance your learning and absorb complex information in an interactive, dynamic way. Deepen your understanding of epidemiology and the important role it plays in providing evidence-based identification of key risk factors for disease and targets for preventive medicine. A completely re-written chapter on this topic keeps abreast of the very latest findings.
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  • In the culminating volume of her nationalism trilogy, Greenfeld argues that we have overlooked the connection between egalitarian society and mental illness. Modern nationalism rests on principles of popular sovereignty, equality, and secularism. Citizens of the twenty-first century enjoy unprecedented freedom to become the authors of their personal destinies. Empowering as this is, it also places them under enormous psychic strain. They must constantly appraise their identities, manage their desires, and calibrate their place within society. For vulnerable individuals, this pressure is too much. Training her analytic eye on extensive case histories in manic depression and schizophrenia, Greenfeld contends that these illnesses are dysfunctions of selfhood caused by society's overburdening demands for self-realization. In her rigorous diagnosis, madness is a culturally constituted malady.
  • Chapter 1. Introduction: Mindful Medical Practice -- Chapter 2. Mindful Rounds, Narrative Medicine, House Calls and Other Stories -- Chapter 3. Lost Heart(beat)/Broken(body) -- Chapter 4. Working with Groups Mindfully -- Chapter 5. The Opera of Medicine -- Chapter 6. The Mindful Psychiatrist: Being Present with Suffering -- Chapter 7. The Death of a Snowflake -- Chapter 8. Carmen's Story -- Chapter 9. A Mindful Life in Medicine: One Pediatrician's Reflections on Being Mindful -- Chapter 10. Embodied Wisdom: Meeting Experience through the Body -- Chapter 11: Minding Baby Abigale -- Chapter 12. Mindfulness in Oncology: Healing Through Relationship -- Chapter 13. Choosing to Survive: A Change in Reproductive Plans -- Chapter 14. Mindfulness in the Realm of Hungry Ghosts -- Chapter 15. In the Heart of Cancer -- Chapter 16. Hiking on the Eightfold Path -- Chapter 17. Strengthening the Therapeutic Alliance Through Mindfulness: One Nephrologist's Experiences -- Chapter 18. Richard's Embers -- Chapter 19. Mindful Decisions in Urogynecological Surgery: Paths from Awareness to Action -- Chapter 20. The Good Mother -- Chapter 21. I Am My Brother's Keeper -- Chapter 22. The Mindful Shift -- Chapter 23. Lifeline -- Chapter 24. Medical Students' Voices: Reflections on Mindlessness During Clinical Encounters -- Chapter 25. Growth and Freedom in 5 Chapters -- Chapter 26. A Wounded Healer's Reflections on Healing -- Chapter 27. Mindfulness, Presence and Whole Person Care -- Chapter 28. Mindful Attitudes Open Hearts in Clinical Practice -- Index.
  • Mindfulness in Therapy -- A Mindful Re-visioning of Couple and Family Therapy Practice -- Mindfulness Research Foundations -- Therapeutic Presence and Mindfulness -- Mindfulness-Informed Case Conceptualization and Treatment Planning -- Teaching Mindfulness Practice in Therapy -- Foundational Mindfulness- and Acceptance- Informed Interventions and Practices -- Mindfulness and Acceptance Interventions for Couples and Families -- Training and Supervision -- Therapist Self-Care and Style of Life.
  • Mineral components in food: analytical implications / M. Biziuk, J. Kuczynska -- Speciation of mineral components in food: analytical implications / A. Polatajko, J. Szpunar -- Criteria of evaluation of food trace analysis data / B. Szteke -- Chemometric techniques in analytical evaluation of food / P. Szefer -- Functional role of some minerals in foods / M. Nabrzyski -- Mineral components and their species in foods of animal origin and honeys / P. Szefer, M. Grembecka -- Mineral components and their species in plant foods, beverages, luxury food, spices and dietary food / P. Szefer, M. Grembecka -- Trace elements in wines / S. Galani-Nikolakaki, N. Kallithrakas-Kontos -- Heavy metals in food packagings / M. E. Conti -- Pollutants in food: metals and metalloids / C. Reilly -- Pollutants in food: radionuclides / Z. Oul-Dada -- Assessment of exposure to chemical pollutants in food and water / P.J. Peterson -- Metal contamination of dietary supplements / M.J. Slotnick, J.O. Nriagu.
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    v. 1. Principles, processes, and systems. 2 pts. -- v. 2. The elements. 2 pts -- v. 3. Calcium physiology.
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  • In recent years, mini-invasive surgery has become increasingly important for reducing the risk of infection and minimizing blood loss and volume of implants. Hip surgery requires small incisions, which make the use of the appropriate equipment and an extensive knowledge of the anatomy of the region essential. Mini-invasive surgery requires the surgeon to consider the indications for surgery for each patient he treats and to know the exact loco-regional anatomy for that patient. Methods must be very precise and warrant visual explanations to help teach young surgeons.
  • Part 1. Introduction -- Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer: Open Questions for Research / Michail Ignatiadis, Christos Sotiriou and Klaus Pantel -- Part 2. Minimal residual disease and breast cancer metastasis -- Self-Seeding in Cancer / Elizabeth Comen and Larry Norton -- Microenvironments Dictating Tumor Cell Dormancy / Paloma Bragado, Maria Soledad Sosa, Patricia Keely, John Condeelis and Julio A. Aguirre-Ghiso -- Part 3. Technologies for circulating tumor cell (CTC) and disseminated tumor cell (DTC) detection and characterization -- Immunomagnetic Separation Technologies / Astrid E. L. M. Hoeppener, Joost F. Swennenhuis and Leon W. M. M. Terstappen -- Microfluidic Technologies / Ali Asgar. S. Bhagat and Chwee Teck Lim -- EPISPOT Assay: Detection of Viable DTCs/CTCs in Solid Tumor Patients / Catherine Alix-Panabières -- Advances in Optical Technologies for Rare Cell Detection and Characterization / Lou Dietz and Richard Bruce -- Size-Based Enrichment Technologies for CTC Detection and Characterization / Anthony Williams, Marija Balic, Ram Datar and Richard Cote -- Emerging Technologies for CTC Detection Based on Depletion of Normal Cells / Maryam Lustberg, Kris R. Jatana, Maciej Zborowski and Jeffrey J. Chalmers -- Molecular Assays for the Detection and Characterization of CTCs / Evi S. Lianidou and Athina Markou -- Multiplex Molecular Analysis of CTCs / Anieta M. Sieuwerts and Stefanie S. Jeffrey -- Part 4. Other blood-based biomarkers / Circulating DNA and Next-Generation Sequencing -- Susanna Cooke and Peter Campbell -- Circulating MicroRNAs as Noninvasive Biomarkers in Breast Cancer / Maria Angelica Cortez, James William Welsh and George Adrian Calin -- Circulating Endothelial Cells and Circulating Endothelial Progenitors / Patrizia Mancuso, Angelica Calleri and Francesco Bertolini -- Part 5. Disseminated tumor cells (DTCs) and circulating tumor cells (CTCs) in breast cancer clinical research and practice -- DTCs in Breast Cancer: Clinical Research and Practice / W. Janni, Brigitte Rack, N. Kasprowicz, C. Scholz and P. Hepp -- CTCs in Primary Breast Cancer (I) / Brigitte Rack, Ulrich Andergassen, Wolfgang Janni and Julia Neugebauer -- CTCs in Primary Breast Cancer (II) / E. Saloustros and D. Mavroudis -- CTCs in Metastatic Breast Cancer / Antonio Giordano and Massimo Cristofanilli -- HER2-Positive DTCs/CTCs in Breast Cancer / Andreas D. Hartkopf, Malgorzata Banys and Tanja Fehm -- DTCs/CTCs in Breast Cancer: Five Decades Later / Susan Alsamarai, Maysa M. Abu-Khalaf and Lyndsay N. Harris -- Part 6. Drug and circulating tumor cell co-development -- Challenges in Drug and Biomarker Co-Development / Sheila E. Taube and Tracy Lively -- Challenges and Opportunities in the Use of CTCs for Companion Diagnostic Development / Elizabeth A. Punnoose and Mark R. Lackner.
  • "Minimally Invasive and Robotic Thyroid and Parathyroid Surgery is the first textbook which includes a comprehensive review of both minimally invasive and robotic thyroid and parathyroid techniques. Over the last several years there has been a rapid expansion in the number of different surgical approaches available to patients undergoing thyroid and parathyroid surgery. This book consolidates these in one source and focuses on both the philosophy and techniques of these procedures. For thyroid surgery, the text covers the full range of minimally invasive procedures and several of the most widely adopted remote access techniques. Several related procedures are also discussed, including minimally invasive approaches to central and lateral neck dissection. For parathyroid surgery, several minimally invasive techniques are covered, including radioguided surgery. Written by experts in the field of thyroid and parathyroid surgery, Minimally Invasive and Robotic Thyroid and Parathyroid Surgery serves as a critical resource for both experienced and less experience surgeons, fellows, residents, and students interested in understanding the breadth of this field or learning the specific steps of a particular technique."--Publisher's website.
  • Part I. Preoperative -- 1. Perioperative Assessment / Charlotte Kvasnovsky and Andrea Chao Bafford -- 2. Patient Positioning, Instrumentation, and Trocar Placement / Mehraneh Dorna Jafari, Michael J. Stamos, and Steven Mills -- 3. Surgical Anatomy / Todd D. Francone and Ron G. Landmann -- Part II. Procedures -- 4. Right Colectomy: Straight Laparoscopic / Steven Robert Hunt -- 5. Right Colectomy: Hand-Assist / Kirk A. Ludwig and Timothy Ridolfi -- 6. Laparoscopic Sigmoidectomy/Left Colectomy / Toyooki Sonoda -- 7. Hand-Assisted Left Colectomy / Steven Lee-Kong and Daniel L. Feingold -- 8. Total Abdominal Colectomy: Straight Laparoscopic Approach / Amanda V. Hayman and Eric J. Dozois -- 9. Total Abdominal Colectomy: Hand- Assisted Approach / Kiyokazu Nakajima, Tsunekazu Mizushima, and Riichiro Nezu -- 10. Operative Details of Laparoscopic Rectal Resection for Cancer / Martin R. Weiser -- 11. Laparoscopic Hand-Assisted Low Anterior Resection / Govind Nandakumar and Sang W. Lee -- 12. Laparoscopic Abdominoperineal Resection / Jennifer S. Davids and Justin A. Maykel -- 13. Laparoscopic Proctocolectomy / David A. Etzioni and Tonia M. Young-Fadok -- 14. Laparoscopic Rectopexy / Mia DeBarros and Scott R. Steele -- 15. Minimally Invasive Approach for Stoma Creation / Seth I. Felder, Zuri Murrell, and Phillip Fleshner -- 16 Laparoscopic Stoma Reversal / Emre Gorgun -- 17. Laparoscopic Parastomal Hernia Repair / Joshua A. Tyler and Matthew G. Mutch -- Part III. Technical Challenges and Tips -- 18. Overcoming Technical Challenges: The Abdomen / Eric K. Johnson -- 19. Overcoming Technical Challenges: The Pelvis / M. Shane McNevin -- 20. Overcoming Technical Challenges: Reoperative Surgery / Brian R. Englum, M. Benjamin Hopkins, and John Migaly -- 21. Overcoming Technical Challenges: Prevention and Managing Complications / Bradley R. Davis -- Part IV. New Horizons -- 22. Single-Incision Laparoscopic Approaches to Colorectal Disease / Virgilio George -- 23. Natural Orifice Surgery (NOTES) / Mark H. Whiteford -- 24. Robotic Surgery /Mehraneh Dorna Jafari, David E. Rivadeneira, and Alessio Pigazzi -- 25. Transanal Minimally Invasive Surgery (TAMIS): Operative Technique, Pitfalls, and Tips / Francisco Quinteros, Kumaran Thiruppathy, and Matthew R. Albert -- 26. Combined Endo-Laparoscopic Surgery (CELS) / Kelly A. Garrett and Sang W. Lee -- Part V. Special Situations -- 27. Emergent Laparoscopic Colorectal Surgery / Rodrigo Pedraza and Eric M. Haas -- 28. Laparoscopy in the Elderly Patient / Joshua I. S. Bleier and Brian R. Kann -- 29. Laparoscopic Colectomy in the Obese Patient / Arida Siripong and H. David Vargas -- 30. Minimally Invasive Surgery in Crohn's Disease Patients / Chang Sik Yu -- 31. Minimally Invasive Surgery in Ulcerative Colitis Patients / Marco E. Allaix and Alessandro Fichera -- 32. Minimally Invasive Approaches to Colon and Rectal Diseases: Technique and Best Practices--Pediatrics / Eric J. Krebill and Daniel J. Robertson -- 33. Laparoscopy in Pregnant Patients / Melissa M. Alvarez-Downing and David J. Maron -- 34. Economics of Laparoscopic Colectomy / Anthony J. Senagore -- 35. Outcomes of Laparoscopic Surgery / Jennifer Leahy and Rocco Ricciardi -- Part VI. Conclusions -- 36. Future Directions in Minimally Invasive Surgery / Howard M. Ross and Matthew Miller Philp.
  • This book explains the concept of metabolic surgery and provides step-by-step descriptions of all the principal minimally invasive surgical techniques employed to treat morbid obesity. The approach adopted is very practical. For each procedure, indications, technical aspects, clinical management, and outcomes are described, and helpful tips and tricks, highlighted. Guidance is provided on the management of emergencies and potential complications, as well as on general postoperative management and long-term follow-up. The coverage also includes new frontiers of robotic and endoscopic surgery. While the focus is on surgical techniques, emphasis is placed on the need for a multidisciplinary approach, with explanation of the role of the multidisciplinary team and the bariatric center. In addition, important information is presented on the definition of morbid and severe obesity, incidence/prevalence, pathophysiology, and obesity-related comorbidities. The authors are internationally acknowledged experts who present best practice know-how in the field and draw on the most recent research literature.
  • The second edition of Minimally Invasive Bariatric Surgery provides a comprehensive, state-of-the art review of this field, and it serves as a valuable resource for clinicians, surgeons and researchers with an interest in minimally invasive bariatric surgery. Additionally, the second edition includes new features that will benefit the resident, fellow, or bariatric surgeon new to the field. Specifically, each evidence-based chapter (i.e. outcomes, complications, epidemiology, etc) concludes with three or four exam questions that emphasize the salient points of the chapter and provide fellowship programs a valuable training tool and resource for their academic curriculum. These questions are either single-answer multiple choice or true/false format and the correct response with a brief explanation follows. As more emphasis is placed on completing a comprehensive curriculum and obtaining certification for bariatric training, this aspect of the book is unique and provides added value to the text. The new edition also incorporates many new or updated medical illustrations to enhance the technique chapters and provide more uniformity for the artwork throughout the book. Each of the major procedures include surgical technique, outcomes, and management of complications in separate chapters to provide an easy reference for the busy clinician preparing for a case or presentation. Another unique feature of the text is a link to video files hosted online for the relevant chapters. This video library will be of great value to the user. As the number of fellowships in laparoscopic bariatric surgery continues to increase, this updated text will provide a valuable resource for general and bariatric surgeons, laparoscopic surgeons, fellows, residents, medical students, obesity researchers, and industry representatives involved in this field. Minimally Invasive Bariatric Surgery is a valuable resource for Medical students, surgical oncology fellows, general surgeons, and educators.
  • As minimal access approaches to cancer diagnosis, staging, and therapy become more widely used, it is vital for general surgeons, along with laparoscopists, surgical oncologists and medical oncologists, to stay up to date. The editors, a team consisting of a renowned surgical oncologist and a laparoscopic specialist, aim to provide a resource for the practicing general surgeon using basic minimally invasive techniques. The book discusses diagnosis including biopsy with microinstrumentation, staging, and palliative and curative resection. Specific tumor sites are addressed, including esophagus, stomach, spleen, small bowel, pancreato-biliary, hepatic resection, and colo-rectal resection. Minimally invasive approaches to the thoracic and retroperitoneal areas are included. The book provides a thorough overview of basic cancer biology, instrumentation, and ultrasound. Additionally, Greene and Heniford explore controversial issues such as port-site recurrence and the effect of pneumoperitoneum on the spread of cancer cells in the abdomen. Many photographs and line drawings, including 16 in full color, illustrate the principles discussed in the text. A must-have for every practicing general surgeon, laparoscopic fellow, and general surgery resident.
  • Botox® cosmetic / Alan Matarasso, David Shafer -- Chemical peels / Richard H. Bensimon -- Radiofrequency ablation for the reduction of glabellar frowning / James Newman -- Dermabrasion . Farzad R. Nahai -- Wire dissection to correct facial rhytids / Miles H. Graivier -- Use of barbed sutures in the face / Malcolm D. Paul -- Facial rejuvenation with structural fat grafting / Alesia P. Saboeiro, Sydney R. Coleman / Necklift vs neck rejuvenation / Patrick K. Sullivan, Erik A. Hoy -- Short-scar facelift / Alexis M. Verpaele, Patrick L. Tonnard -- Endoscopic brow lift / Renato Saltz, Mark A. Codner -- Treatment of the superficial musculo-aponeurotic system during minimally invasive facial rejuvenation / Salvatore J. Pacella, Farzad Nahai, Mark A. Codner -- Limited Incision midface lift / Oscar M. Ramirez. DVD Contents: Clinical uses of Botox® / Alan Matarasso, David M. Shafer -- Trichloracetic acid chemical peel / Mark A. Codner -- Croton oil peel / Richard H. Bensimon -- Dermabrasion / Farzad R. Nahai -- Wire dissection to correct facial rhytids / Miles H. Graivier -- Submental dissection /Farzad R. Nahai -- Short scar facelift / Foad Nahai -- Endoscopic browlift / Mark A. Codner -- Limited incision midface lift / Oscar M. Ramirez.
  • Minimally Invasive Forefoot Surgery in Clinical Practice describes a number of the better established and accepted minimally invasive surgical correction techniques for forefoot problems, and is aimed at junior and general orthopedic surgeons who require a useful easy reference for these procedures.The concise written text is complemented by a generous assortment of useful photos, diagrams, and imaging studies.
  • This book provides detailed, comprehensive and illustrative content to the surgical community in the areas of foregut oncologic surgery. The text contains an in-depth review of all surgical aspects of oncologic diseases involving the stomach and esophagus. The main focus is on the minimally invasive techniques including potential complications and their management. The text also includes an online link to the videos for all minimally invasive foregut surgical procedures, including animation content which provide a more comprehensive learning experience. Minimally Invasive Foregut Surgery for Malignancy: Principles and Practice is structured in a way that makes it useful at every level of training and will be of great utility to practicing surgeons, fellows in surgical subspecialty training and surgical residents.
  • Part I. -- Techniques -- Endoscopic techniques, equipment, and optics / Liliana C. Goumnerova -- MR imaging of the central nervous system / Liangge Hsu -- Proton MR spectroscopy / Amir A. Zamani -- Functional brain mapping options for minimally invasive neurosurgery / Alexandra J. Golby and Kathleen A. McConnell -- Image guidance in minimally invasive neurosurgery / Richard D. Bucholz and Lee McDurmont -- Intraopertive imaging using the siemans and tesla MR systems / Christopher Nimsky and Rudolf Fahlbusch -- Endovascular treatment of intracranial aneurysms / Christos Gkogkas, John Baker, Alexander M. Norbash, and Kai U. Frerichs -- Stent angioplasty for the treatment of intracranial cerebrovascular disease / Adel M. Malek and Clemens M. Schirmer -- The role of embolic agents in the endovascular treatment of intracranial arteriovenous malformations and tumors / Ricardo A. Hanel, Bernard R. Bendok, Jay U. Howington, Elad I. Levy, Lee R. Guterman, and L. Nelson Hopkins -- Radiofrequency lesioning / Michael Petr and John M. Tew, Jr. -- Radiosurgery:tTechniques and applications / William A. Friedman -- MRI-guided thermal therapy for brain tumors / Ferenc A. Jolesz and Ion-Florin Talos -- Gene-based and viral-based therapies / Manish Aghi and E. Antonio Chiocca -- Local delivery methods into the central nervous system / Timothy W. Vogel and Jeffrey N. Bruce -- Part II Specialties -- Minimally invasive pediatric neurosurgery / Michael Weaver and Mark R. Proctor -- Minimally invasive techniques in vascular neurosurgery / Prithvi Narayan and Daniel L. Barrow -- Minimally invasive treatment for brain tumors / Dennis S. Oh and Peter M. Black -- New directions in spinal surgery / Ian F. Dunn and Marc E. Eichler -- Endoscopic techniques in the management of carpal tunnel syndrome / David F. Jimenez -- Minimally invasive procedures in traumatic brain injury / Edward Ahn, William C. Chiu, Max Wintermark, Bizhan Aarabi, and Howard Eisenberg
  • Minimally invasive oculoplastic surgery / Michèle Beaconsfield and Richard Collin -- Minimally invasive conjunctival surgery / Shigeru Kinoshita ... [et al.] -- Minimally invasive lacrimal surgery / Rainer K. Weber -- Minimally invasive corneal surgery / Heather M. Skeens and Edward J. Holland -- Minimally invasive refractive surgery / Jorge L. Alio, Mohamad Rosman, and Samuel Arba Mosquera -- Minimally invasive strabismus surgery / Daniel S. Mojon -- Minimally invasive iris surgery / Roger F. Steinert -- Minimally invasive glaucoma surgery / Elie Dahan ... [et al.] -- Minimally invasive cataract surgery / I. Howard Fine, Richard S. Hoffman, and Mark Packer -- Minimally invasive vitreoretinal surgery / Loh-Shan Leung, Woo Ho Nam, and Stanley Chang.
  • Daniel H. Kim, MD, FACS, Kyung Hoon Kim, MD, and Yong Chul Kim, MD, helps you apply methods of spinal pain relief that involve less risk and shorter recovery times. Focusing on the broad appeal of this goal for you and your patients, this volume will help surgeons and specialists in various areas of pain management provide less invasive alternatives and faster recovery procedures for those suffering with spinal injuries. Step-by-step techniques are well-illustrated in the book and demonstrated extensively on DVD. Reduce the risk associated with invasive spinal procedures by considering new perspectives on pain management techniques that can be used by specialists from various disciplines. Address the growing need for less invasive surgeries with shorter recovery times among a large and aging population with musculoskeletal problems. You and your patients both want less invasive, less risky options for faster recovery & better outcomes.
  • Contemporary spinal surgeons, whether orthopedic or neurosurgeons, are increasingly recognizing minimally invasive spine surgery (MISS) as a valuable option for managing advanced degenerative diseases. MISS techniques minimize blood loss and surgical site pain, while speeding recovery. Thus, the combination of MISS with adult spinal deformity was a natural choice. Currently, the techniques, technologies, and education of surgeons have finally reached a point where MISS deformity surgeries are becoming commonplace. Nevertheless, the field is young enough (and still evolving) that no comprehensive texts have addressed the unique challenges it poses for surgeons. This book fills that gap.
  • A minimally invasive open approach for reconstruction of the anterior column of the thoracic and lumbar spine / B. Knowles ... [et al.] -- Percutaneous vertebroplasty in osteoporotic vertebral fractures / G.M. Hess, H.M. Mayer -- Microsurgical open vertebroplasty and kyphoplasty / B.M. Boszczyk ... [et al.] -- Percutaneous kyphoplasty in traumatic fractures / G. Maestretti, P. Otten -- Lumbar spine. Low back pain. Inteventional and semi-invasive procedures for low back pain and disc herniation / M.K. Schäufele -- Disc. Intradiscal electrothermal therapy / J. Saal -- Microtherapy in low back pain / A.T. Yeung, C.A. Yeung -- Principles of microsurgical discectomy in lumbar disc herniations / H.M. Mayer -- The microsurgical interlaminar, paramedian approach / H.M. Mayer -- The translaminar approach / L. Papavero -- General. Minimally invasive spine surgery / H.M. Mayer -- Technological advances of surgical microscopes for spine surgery / W. Rulffes -- Spinal microsurgery: a short introduction / H.M. Mayer -- Microsurgical instruments / A. Korge -- Operating room setup and handling of surgical microscopes / K. Wiechert -- Computer-assisted minimally invasive spine surgery - state of the art / F. Langlotz, L.P. Nolte -- Cervical spine. Odontoid. Technique of transoral odontoidectomy / P.J. Apostolides ... [et al.] -- Microsurgical treatment of odontoid fractures / P. Klimo Jr., G. Rao, R.I. Apfelbaum -- Disc surgery/decompression. Microsurgery of the cervical spine: the anterior approach / L. Papavero -- Anterior cervical foraminotomy (microsurgical and endoscopic) / W.F. saringer -- Functional segmental reconstruction with the Bryan cervical disc prosthesis / J. Goffin -- Microsurgical total cervical disc replacement / H.M. Mayer -- Microsurgical posterior approaches to the cervical spine / P.H. Young, J.P. Young, J.C. Young -- Microsurgical C1 - 1 stabilization / D. Fassett, R.I. Apfelbaum -- Thoracic/thoracolumbar spine. General techniques. Microsurgical anterior approach to T5 - 10 (Mini-TTA) / H.M. Mayer -- Microsurgical anterior approach to the thoracolumbar junction / H.M. Mayer -- Anatomic principles of thoracoscopic spine surgery / U. Liljenqvist -- Principles of endoscopic techniques to the thoracic and lumbar spine / G.M. McCullen, A.A. Criscitiello, H.A. Yuan -- Biomechanical requirements in minimally invasive spinal fracture treatment / M. Schultheiss ... [et al.] -- Deformities. Thoracoscopic approaches in spinal deformities and trauma / M. Dufoo-Olvera -- Thoracoscopic techniques in spinal deformities / D. Sucato -- Mini-open endoscopic excision of hemivertebrae / R. Stücker -- Fractures. Thoracoscopically assisted anterior approach to thoracolumbar fractures / R. Beisse -- Spinal stenosis. Microsurgical decompresssion of acquired (degenerative) central and lateral spinal canal stenosis / H.M. Mayer -- Fusion. Microsurgical anterior lumbar interbody fusion (Mini-ALIF): the lateral retroperitoneal approach to L2/3, L3/4, and L4/5 / H.M. Mayer -- Microsurgical anterior lumbar interbody fusion (Mini-ALIF): the transperitoneal approach to L5/S1 / H.M. Mayer -- Minimally invasive 360° lumbar fusion / M. Aebi -- The anterior extraperitoneal video-assisted approach to the lumbar spine / M. Onimus, H. Chataigner -- Dynamic stabilization. Minimally invasive dynamic stabilization of the lumbar motion segment with an interspinous implant / J. Sénégas -- Technical and anatomical considerations for the placement of a posterior interspinous stabilizer / J. Taylor, S. Ritland -- Elastic microsurgical stabilization with a posterior shock absorber / S. Caserta, G.A. La Maida, B. Misaggi. The lateral, extraforaminal approach / L. Papavera -- Transforaminal endoscopic discectomy / J. Krugluger -- Microscopically assisted percutaneous technique as a minimally invasive approach to the posterior spine / R. Greiner-Perth, H. Boehm, E. El Saghir -- Arthroscopic and endoscopic spine surgery via a posterolateral approach / P. Kambin -- The full-endoscopic interlaminar approach for lumbar disc herniations / S. Ruetten -- Outpatient microsurgical lumbar discectomy and microde-compression laminoplasty / R.S. Biscup, V. Podichetty -- Disc reconstruction. Nucleus reconstruction by autologous chondrocyte transplantation / H.-J. Meisel, T. Ganey -- Autologous disc chondrocyte transplantation / F. Grochulla, H.M. Mayer, A. Korge -- The ALPA approach for minimally invasive nucleus pulposus replacement / R. Bertagnoli -- Mini-open midline accesses for lumbar total disc replacement / H.M. Mayer --
  • Over the past decade, minimally invasive techniques have developed rapidly and are widely applied in the management of spine disorders. With the development of enabling technologies, including specifically designed spinal retractor systems, intra-operative imaging and navigation technologies, and real-time neural monitoring, minimally invasive spine surgery (MISS) techniques are safe, effective and reproducible. Indeed, studies have confirmed the clinical and economic advantages of these procedures. Minimally Invasive Spine Surgery includes detailed discussions of enabling technologies, surgical techniques (including posterior decompression and fusion), approaches to specific diseases and conditions, as well as strategies to manage the unique risks and complications of MISS. Generously illustrated, this will be an essential reference for orthopedic surgeons, neurosurgeons and all health care professionals who treat the spine.
  • Minimally Invasive Surgery for Achilles Tendon Disorders in Clinical Practice is a collection of procedures presented by experts and pioneers in foot and ankle surgery who share an interest in developing less invasive methods of treating disorders of the foot and ankle. The rate of complications of traditional surgery is extremely high: in the management of tendinopathy, traditional techniques result in 10% of patients experiencing a complication related to skin healing. It is therefore not surprising that less invasive techniques have been advocated.This book will serve as an excellent pocket reference when repairing disorders of the Achilles and aimed general orthopedic surgeons and specialist who require a useful easy reference for these procedures.
  • Introduction / Joachim Pfeil -- Anatomy of the Hip Joint / Joachim Pfeil -- Complications / Joachim Pfeil -- Patient Selection, Indications and Contraindications / Joachim Pfeil -- The Anterior Approach / Etienne Lesur -- The Anterolateral Approach with the Patient in Lateral Position / Werner Siebert -- The Anterolateral Approach with the Patient in Supine Position / Joachim Pfeil -- The Posterior Approach / Modaine J -- Epilogue / Werner Siebert.
  • Minimally invasive foot surgery: a paradigm shift -- Computer-assisted surgery (CAS) in foot and ankle surgery -- Tendoscopy -- Arthroscopy of the first metatarsophalangeal joint -- Minimally invasive management of hallux rigidus -- Percutaneous first metatarso-phalangeal joint fusion -- The Reverdin-Isham procedure for the correction of hallux valgus: a distal metatarsal osteotomy procedure using minimal invasive technique -- Arthroscopic assisted correction of hallux valgus deformity -- Minimally invasive hallux valgus correction -- Minimally invasive modified Wilson osteotomy for the treatment of hallux valgus -- Percutaneous surgery for static metatarsalgia -- Percutaneous treatment of static metatarsalgia with distal metatarsal mini-invasive osteotomy -- Isham hammertoe procedures for the correction of lesser digital deformities -- Minimally invasive management of dorsiflexion contracture at the metatarsophalangeal joint and plantarflexion contracture at the proximal interphalangeal joint of the fifth toe -- Arthroscopic assisted correction of lesser toe deformity -- Percutaneous fixation of proximal fifth metatarsal fractures -- Minimally invasive realignment surgery of the charcot foot -- Arthroscopic triple arthrodesis -- Percutaneous calcaneal displacement osteotomy -- Tendoscopy of the flexor halluces longus tendon -- Open reduction and internal fixation of calcaneal fractures through a combined medial and lateral approach using a small incision technique -- Endoscopic plantar fasciotomy -- Arthroscopic Os trigonum excision -- Endoscopic calcaneoplasty -- Postero-medial approach in the supine position for posterior ankle endoscopy -- Ankle equinus and endoscopic gastrocnemius recession -- Athroscopic arthrodesis of the ankle -- Percutaneous osteosynthesis of distal tibial fractures using locking plates -- Percutaneous supramalleolar osteotomy using the Ilizarov/Taylor spatial frame -- Minimally invasive management of syndesmotic injuries -- Endoscopic assisted percutaneous Achilles tendon repair -- Percutaneous repair of acute Achilles tendon ruptures -- Minimally invasive semitendinosus tendon graft augmentation for reconstruction of chronic tears of the Achilles tendon -- Minimally invasive Achilles tendon reconstruction using the peroneus brevis tendon graft -- Free hamstrings tendon transfer and interference screw fixation for less invasive reconstruction of chronic avulsions of the Achilles tendon -- Percutaneous longitudinal tenotomies for chronic Achilles tendinopathy -- Minimally invasive stripping for chronic Achilles tendinopathy.
  • The treatment of liver diseases comprises a significant component of the practice of any general surgeon, whether working in an academic, a general, or a community hospital. With the rapid expansion in knowledge and technology, the liver has also been approached laparoscopically in specialized centers, with well-recognized advantages for patients. This book aims to communicate the large body of experience that has now been accumulated in minimally invasive liver surgery, with comprehensive and up-to-date information on the newest techniques. After a concise description of the main tools and technology necessary to carry out safe laparoscopic and/or robot-assisted liver surgery, individual operative techniques are explained and illustrated. Each chapter includes introductory information, a summary of indications and contraindications, and a detailed description of surgical procedure, including potential complications of both the surgery and the postoperative care. Special efforts have been taken to ensure that the illustrations are accurate and informative. The text is supplemented by a DVD of different procedures as performed by leading European liver surgeons.
  • Minimally invasive procedures are increasingly utilized and are replacing open surgery to reduce scarring and pain, enhance patient recovery, and minimize cost. This guide provides step-by-step guidance, expert instruction, and detailed illustration of the most recent minimally invasive orthopedic spine procedures. With a variety of chapters covering critical developments in the field including the utilization of biologic materials, image-guided surgery, and bone fusion, this guide delves into discussions of indications, methods for preoperative planning, complication avoidance strategies.
  • The past 20 years have witnessed an extraordinarily rapid adoption of minimally invasive surgical techniques, and increasingly these techniques are being employed in the diagnosis and treatment of a wide range of malignancies. This book is designed to serve as a unique and comprehensive overview of the current status of minimally invasive surgery in oncology patients and in addition offers valuable insights into the future of this constantly evolving field. The first section of the book is devoted to essential background information and to explaining what is physiologically distinctive in the cancer patient undergoing laparoscopic surgery. The second section then examines in detail a wide range of clinical aspects and issues across different disciplines, with clear instruction on the use of minimally invasive procedures. The aim is to enable the reader to make treatment decisions appropriate to the individual patient, to carry them out effectively, and to institute suitable postoperative care. Summaries of the latest knowledge in traditional therapies such as chemotherapy are also provided when appropriate. Each chapter is written by a recognized expert, and numerous high-quality illustrations are included to assist understanding. This book will serve both as a clinical reference guide and as an operative atlas, and is certain to prove invaluable in daily clinical practice.
  • "Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse provides a detailed insight into "when, why, what and how" of various minimally invasive surgical procedures for surgical management of SUI, OAB & POP. The volume provides detailed diagrammatic and pictorial step-by-step descriptions of the techniques and management of complications related to these procedures. This book also presents an up to date, one-stop reference for anything pertaining to MIT of these pelvic disorders. Written by experts in the field, Minimally Invasive Therapy for Urinary Incontinence and Pelvic Organ Prolapse is a comprehensive resource designed for both the urologist and urogynecologist treating patients with urinary disorders and pelvic organ prolapsed, as well as for residents in training."--Publisher's website.
  • Part I. Minimally invasive thoracic surgery, general -- Part II. Minimally invasive thoracic surgery, the lung -- Part III. Minimally invasive thoracic surgery, the pleura -- Part IV. Minimally invasive thoracic surgery, the mediastinum -- Part V. Minimally invasive thoracic surgery, chest wall -- Part VI. Minimally invasive thoracic surgery, the oesophagus -- Part VII. Minimally invasive thoracic surgery, the diaphragm -- Part VIII. Minimally invasive cardiac surgery, general -- Part IX. Minimally invasive cardiac surgery, the heart -- Index.
  • This book describes in detail the various techniques of minimally invasive thyroidectomy that have emerged in recent years and presents the new supportive equipment, including intraoperative monitoring and energy devices. In addition, the basic preoperative techniques that are a prerequisite to successful thyroidectomy are covered, and individual chapters are devoted to complications, outcomes, and post-thyroidectomy quality of life. Important related topics are also discussed, including guidelines for managing papillary and medullary thyroid cancer and the surgical management of metastatic lymph nodes. Both the editors and the authors are internationally renowned experts, and they include the founders of several of the techniques described. The up-to-date text is supplemented by many color pictures and medical illustrations, making the book very user-friendly and ideal for the busy surgeon or endocrinologist who is interested in the management of thyroid diseases.
  • Introduction: Minimizing: A Continuous Trend in Cataract Surgery / I. Howard Fine, Jorge Alio, Mark Packer, Richard S. Hoffman and Peter Allan Karth -- The Transition Towards Smaller and Smaller Incisions: Micro-Coaxial Phacoemulsification with Torsional Ultrasound / James M. Osher and Robert H. Osher -- Transitioning to Bimanual MICS / Rosa Braga-Mele -- 0.7 mm Microincision Cataract Surgery / Jorge L. Alió, Amar Agarwal and Pawel Klonowski -- MICS Instrumentation / Jorge L. Alió, Pawel Klonowski and Jose L. Rodriguez-Prats -- Evolution of Ultrasound Pumps and Fluidics and Ultrasound Power: From Standard Coaxial Towards the Minimal Incision Possible in Cataract Surgery / William J. Fishkind -- Coaxial Microincision Cataract Surgery Utilizing Non-Linear Ultrasonic Power: An Alternative to Bimanual Microincision Cataract Surgery / Stephen S. Lane -- Technology Available: How to Better Use Fluidics with MICS / Rupert Menapace and Silvio Di Nardo -- How to Use Power Modulation in MICS / Randall J. Olson -- MICS with Different Platforms / Arturo Pèrez-Arteaga -- Using the Alcon Infiniti and AMO Signature for MICS / Richard Packard -- MICS with Different Platforms: Stellaris Vision Enhancement System / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Surgical Technique - How to Perform a Smooth Transition / Mark Packer, Jennifer H. Smith, I. Howard Fine and Richard S. Hoffman -- Pupil Dilation and Preoperative Preparation / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Incisions / I. Howard Fine, Richard S. Hoffman and Mark Packer -- Thermodynamics / Alessandro Franchini, Iacopo Franchini and Daniele Tognetto -- Using Ophthalmic Viscosurgical Devices with Smaller Incisions / Steve A. Arshinoff -- Capsulorhexis / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Hydrodissection and Hydrodelineation / I. Howard Fine, Richard S. Hoffman and Mark Packer -- Biaxial Microincision Cataract Surgery: Techniques and Sample Surgical Parameters / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Biaxial Microincision Phacoemulsification: Transition, Techniques, and Advantages / Richard S. Hoffman, I. Howard Fine and Mark Packer -- BiMICS vs. CoMICS: Our Actual Technique (Bimanual Micro Cataract Surgery vs. Coaxial Micro Cataract Surgery) / Jerome Bovet -- Endophthalmitis Prevention / Ayman Naseri and David F. Chang -- Biaxial Microincision Phacoemulsification for Difficult and Challenging Cases / I. Howard Fine, Jorge L. Alió, Richard S. Hoffman and Mark Packer -- MICS in Special Cases: Incomplete Capsulorhexis / Arturo Pérez-Arteaga -- MICS in Special Cases (on CD): Vitreous Loss / Jerome Bovet -- How to Deal with Very Hard and Intumescent Cataracts / L. Felipe Vejarano and L. F. Vejarano -- IOL Types and Implantation Techniques: MICS Intraocular Lenses / Jorge L. Alió and Pawel Klonowski -- Implantation Techniques / T. Amzallag -- Special Lenses: Toric Posterior Chamber Intraocular Lenses in Cataract Surgery and Refractive Lens Exchange / Gerd U. Auffarth, Tanja M. Rabsilber and Miriam Casper -- Special Lenses: MF / Hakan Kaymak and Ulrich Mester -- Special Lenses: Aspheric / Mark Packer, I. Howard Fine and Richard S. Hoffman -- Intraocular Lenses to Restore and Preserve Vision Following Cataract Surgery / Robert J. Cionni and David Hair -- Microincision Intraocular Lenses: Others / Richard S. Hoffman, I. Howard Fine and Mark Packer -- Outcomes: Safety: MICS versus Coaxial Phaco / George H. H. Beiiko Control of Corneal Astigmatism and Aberrations / Jorge L. Alió and Bassam El Kady -- Corneal Endothelium and Other Safety Issues / H. Burkhard Dick -- Incision Quality in MICS / Bassam El Kady and Jorge L. Aliió
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  • 1. Specification mining : a concise introduction / David Lo ... [et al.] -- 2. Mining finite-state automata with annotations / Leonardo Mariani ... [et al.] -- 3. Adapting grammar inference techniques to mine state machines / Neil Walkinshaw and Kirill Bogdanov -- 4. Mining API usage protocols from large methods traces / Michael Pradel and Thomas R. Gross -- 5. Static API specification mining : exploiting source code model checking / Mithun Acharya and Tao Xie -- 6. Static specification mining using automata-based abstractions / Eran Yahav ... [et al.] -- 7. DynaMine : finding usage patterns and their violations by mining software repositories / Benjamin Livshits and Thomas Zimmermann -- 8. Automatic inference and effective application of temporal specifications / Jinlin Yang and David Evans -- 9. Path-aware static program analyses for specification mining / Muralikrishna Ramanathan, Ananth Grama, and Suresh Jagannathan -- 10. Mining API usage specifications via searching source code from the Web / Suresh Thummalapenta, Tao Xie, and Madhuri R. Marri -- 11. Merlin : specification inference for explicit information flow problems / Benjamin Livshits ... [et al.] -- 12. Lightweight mining of object usage / Andrzej Wasylkowski and Andreas Zeller.
  • Crawling the Web -- Web search and information retrieval -- Similarity and clustering -- Supervised learning -- Semisupervised learning -- Social network analysis -- Resource discovery -- The future of Web mining.
  • Section 1. Origin and management of the minipig -- section 2. Welfare and experimental usage of the minipig -- section 3. Pharmacology and ADME studies in the minipig -- section 4. Safety assessment in the minipig : principal body systems -- section 5. Genetics and immunology -- section 6. Disease models -- section 7. Regulatory perspective and use of the minipig in developing marketed products -- section 8. New horizons and perspectives.
  • Minor emergencies. 3rd ed. 2012
    2012 ClinicalKey
  • Aquaporins : a family of highly regulated multifunctional channels / Charles Hachez and François Chaumont -- Phylogeny of major intrinsic proteins / Jonas Å.H. Danielson and Urban Johanson -- Metalloids, soil chemistry, and the environment / Enzo Lombi and Peter E. Holm -- Arsenic transport in prokaryotes and eukaryotic microbes / Barry P. Rosen and Markus J. Tamøs -- Metalloid transport by aquaglyceroporins : consequences in the treatment of human diseases / Rita Mukhopadhyay and Eric Beitz -- Roles of vertebrate aquaglyceroporins in arsenic transport and detoxification / Zijuan Liu -- Molecular mechanisms of boron transport in plants : involvement of arabidopsis NIP5;1 and NIP6;1 / Kyoko Miwa ... [et al.] -- Silicon transporters in higher plants / Jian Feng Ma -- Major intrinsic proteins and arsenic transport in plants : new players and their potential roles / Gerd P. Bienert and Thomas P. Jahn -- Major intrinsic proteins in biomimetic membranes / Claus Hølix Nielsen.
  • "The United States health care system is the most expensive in the world, but comparative analyses consistently show the U.S. underperforms relative to other countries on most dimensions of performance. Among the 11 nations studied in this report --Australia, Canada, France, Germany, the Netherlands, New Zealand, Norway, Sweden, Switzerland, the United Kingdom, and the United States -- the U.S. ranks last, as it did in prior editions of Mirror, Mirror. The United Kingdom ranks first, followed closely by Switzerland. Since the data in this study were collected, the U.S. has made significant strides adopting health information technology and undertaking payment and delivery system reforms spurred by the Affordable Care Act. Continued implementation of the law could further encourage more affordable access and more efficient organization and delivery of health care, and allow investment in preventive and population health measures that could improve the performance of the U.S. health care system."--Abstract.
  • Section I. The Shoulder and Elbow -- Mini-Incision bankart Repair for Shoulder Instability / Edward W. Lee and Evan L. Flatow -- Mini-Open Rotator Cuff Repair / Jason A. Schneider and Frances Cuomo -- Mini-Incision Fixation of Proximal Humeral Four-Part Fractures / Jim Hsu and Leesa M. Galatz -- Minimally Invasive Approach for Shoulder Arthroplasty / Theodore Blaine, Ilya Voloshin, Kevin Setter and Louis U. Bigliani --Mini-Incision Medial Collateral Ligament Reconstruction of the Elbow / Steven J. Thornton, Andrew Willis and David W. Altchek -- Mini-Incision Distal Biceps Tendon Repair / Jason A. Schneider and Peter D. McCann -- Section II. The Hip -- A Technique for the Anterolateral Approach to MIS Total Hip Replacement / Richard A. Berger -- The Anterior Approach for Total Hip Replacement: Background and Operative Technique / Joel M. Matta -- Posterolateral Minimal Incision for Total Hip Replacement: Technique and Early Results / Mark A. Hartzband -- Minimally Invasive Total Hip Arthroplasty Using the Two-Incision Approach / Richard A. Berger -- Minimally Invasive Metal-on-Metal Resurfacing Arthroplasty of the Hip / Hari P. Bezwada, Phillip S. Ragland, Craig M. Thomas and Michael A. Mont -- Section III. The Knee: Unicondylar Knee Arthroplasty -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Bone-Sparing Technique / John A. Repicci and Jodi F. Hartman -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Intramedullary Technique / Richard A. Berger and Alfred J. Tria -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Extramedullary Tensor Technique / Paul L. Saenger -- Minimally Invasive Surgery for Unicondylar Knee Arthroplasty: The Extramedullary Technique / Giles R. Scuderi -- Minimally Invasive Surgery for Arthroplasty with the UniSpacer / Richard H. Hallock -- Minimally Invasive Technique for Insertion of a Unicompartmental Knee Arthroplasty / A. J. Price and D. W. Murray -- Section IV. The Knee: Total Knee Arthroplasty -- Minimal Incision Total Knee Arthroplasty with a Limited Medial Parapatellar Arthrotomy / Giles R. Scuderi -- Minimally Invasive Total Knee Replacement with the Quadriceps-Sparing Subvastus Approach / Mark W. Pagnano and Giles R. Scuderi -- Mini-Midvastus Total Knee Arthroplasty / Steven B. Haas, Andrew P. Lehman and Mary Ann Manitta -- Minimally Invasive Lateral Approach to Total Knee Arthroplasty / Hari P. Bezwada, Michael A. Mont, Peter M. Bonutti, Phillip S. Ragland and Craig M. Thomas, et al. -- Minimally Invasive Total Knee Arthroplasty Using the Quadriceps-Sparing Approach / Alfred J. Tria -- Section V. Computer Navigation -- Computer-Guided Total Hip Arthroplasty / James B. Stiehl -- Computer-Guided Total Knee Arthroscopy / Alon Wolf, Branislav Jaramaz, Andrew B. Mor and Anthony DiGioia.
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    Many of the examples involve physicians and medical situations, both clinical and research.
  • Mistletoe through cultural and medical history : the all-healing plant proves to be a cancer-specific remedy / Ramm, H. -- Chemical constituents of viscum album L. : implications for the pharmaceutical preparation of mistletoe / Urech, K.; Baumgartner, S. -- The anti-cancer activity of mistletoe preparations, as related to their polyphenolic profiles / Schramm, H.M. -- From Berlin and Witten to Southampton and Hamburg : 25 years of mistletoe research cooperation / Schumacher, U.; Pfüller, U. -- Mistletoe compounds as anti-cancer drugs : effects and mechanisms in the treatment of glioblastoma / Schötterl, S.; Naumann, U. -- Cancer surgery and supportive mistletoe therapy : from scepticism to randomised clinical trials / Galun, D.; Tröger, W.; Milicevic, M. -- Dissecting the anti-inflammatory effects of viscum album : inhibition of cytokine-induced expression of cyclo-oxygenase-2 and secretion of prostaglandin E2 / Elluru, S.R.; Saha, C.; Hedge, P.; Friboulet, A.; Bayry, J.; Kaveri, S.V. -- Dancing with the Devil : cancer-related fatigue, from inflammation to treatment options / Zänker, K.S.
  • Part 1. General principles of mitochondria and the heart -- Introduction to Mitochondria in the Heart -- Methods to Study Mitochondrial Structure and Function -- Mitochondrial Structure, Composition, and Dynamics -- Mitochondrial Biogenesis -- Mechanisms of Bioenergy Production in Mitochondria -- Bioenergetics Interplay Between Cardiac Mitochondria and Other Subcellular Compartments -- Part 2. Heart mitochondria signal transduction. Stem cells -- Endothelial Mitochondria: Contribution to Cardiovascular Function and Disease -- Heart Mitochondria: Receivers and Transmitters of Signals -- Stem Cells and Mitochondria -- Part 3. Stress and cell death -- Heart Mitochondrial ROS and Oxidative Stress -- Cell-Death Pathways and Mitochondria -- Part 4. Mitochondria in Pediatric Cardiology -- Mitochondria in Pediatric Cardiovascular Diseases -- Part 5. The aging heart and mitochondria -- Mitochondria in the Aging Heart -- Part 6. Mitochondria in Atherosclerosis, hypertension and ischemia -- The Role of Mitochondria in Atherosclerosis -- The Role of Mitochondria in Hypertension -- Role of Mitochondria in Ischemia and Cardioprotection -- Part 7. Mitochondria in Heart Failure and Dysrhythmias -- Mitochondrial Dynamics in Health and Disease -- Mitochondria Play an Essential Role in Heart Failure -- Mitochondria and Cardiac Dysrhythmias -- Part 8. Mitochondria in heart metabolism -- Diabetes and Cardiac Mitochondria -- The Role of Mitochondria in the Metabolic Syndrome and Insulin Resistance -- Thyroid Hormone and Myocardial Mitochondria -- Part 9. Mitochondrial Therapy -- Targeting the Mitochondria in Cardiovascular Diseases -- Part 10. Looking to the future of mitochondria and the heart -- Current Progress and Future Perspectives: Toward Mitochondrial Medicine.
  • This book highlights the importance of phytochemicals and mitochondria in cancer prevention and therapy. Recent scientific discoveries have identified that naturally occurring biologically active compounds (i.e. phytochemicals) target multiple steps of tumorigenesis leading to the inhibition or delay in cancer progression. Mitochondria, organelles within a cell, are a critical target for phytochemicals in regulating the initiation, promotion, and progression of cancer.
  • Introduction to mitochondria / Carolyn D. Berdanier -- Mitochondrial bioenergetics in intact tissue / Richard L. Veech -- The human mitochondrial genome: mechanisms of expression and maintenance / Jan-Willem Taanman and Sion Llewellyn Williams -- Oxidative phosphorylation disease: diagnosis and pathogenesis / John M. Shoffner -- Using mitochondrial DNA in population surveys / Carolyn D. Berdanier -- Mitochondrial DNA mutation, oxidative stress, and alteration of gene expression in human aging / Hsin--Chen Lee and Yau-Huei Wei -- Mitochondrial DNA in cardiomyopathies / Nobuakira Takeda -- Mitochondria in Diabetes mellitus / Hong Kyu Lee -- Drugs, nutrients, and hormones in mitochondrial function / Carolyn D. Berdanier -- Bacterial FF ATP synthase as a model for complex V / Brian D. Cain, Tammy Bohannon Grabar, and Depa Bhatt -- Cybrids in the study of animal mitochondrial genetics and pathology / Ian A. Trounce and Carl A. Pinkert -- Animal modeling: from transgenesis to transmitochondrial models / Carl A. Pinkert and Ian A. Trounce -- BHE/Cdb rats as tools to study mitochondrial gene expression / Carolyn D. Berdanier and Moon-Jeong Chang Kim -- Appendix 1 -- Appendix 2.
  • Regulation of mitochondrial respiration in heart muscle / Ilmo Hassinen -- Regulation of fatty acid oxidation of the heart / Clifford D.L. Folmes and Gary D. Lopaschuk -- Regulation of mitochondrial fuel handling by the peroxisome proliferator-activated receptors / Mary C. Sugden and Mark J. Holness -- Molecular structure of the mitochondrial citrate transport protein / Ronald S. Kaplan and June A. Mayor -- Regulation of pyruvate and amino acid metabolism / Thomas C. Vary, Wiley W. Souba, and Cristopher J. Lynch -- Amino acids and the mitochondria / Nicola King -- Mechanotransduction of shear-stress at the mitochondria / Abu-Bakr Al-Mehdi -- Formation of reactive oxygen species in mitochondria / Julio F. Turrens -- Mitochondrial calcium : role in the normal and ischaemic/reperfused myocardium / Elinor J. Griffiths ... [et al.] -- Mitochondrial ion channels / Brian O'Rourke -- The mitochondrial permeability transition pore : from molecular mechanism to reperfusion injury and cadioprotection / Andrew P. Halestrap, Samantha J. Clarke, and Igor Khalilin -- The apoptotic mitochondrial pathway : modulators, interventions, and clinical implications / M.-Saadeh Suleiman and Stephen W. Schaffer -- The role of mitochondria in necrosis following myocardial ischemia-reperfusion / Elizabeth Murphy and Charles Steenbergen -- Mitochondria and their role in ischemia/reperfusion injury / Sebastian Phillip, James M. Downey, and Michael V. Cohen -- Mitochondrial DNA damage and repair / Inna N. Shokolenko, Susan P. Ledoux, and Glenn L. Wilson.
  • Mitochondria, practical protocols 2007.
    Springer Protocols
    Offers a broad collection of methods for studying the molecular biology, function, and features of mitochondria. In the past decade, mitochondrial research has elucidated the important influence of mitochondrial processes on integral cell processes such as apoptosis and cellular aging. This practical guide presents a wide spectrum of mitochondrial methods, each written by specialists with solid experience and intended for implementation by novice and expert researchers alike.
  • Mitochondria. 2nd ed. 2007
  • Mitochondrial cytopathies are mutations in the inherited maternal mitochondrial genome, or the nuclear DNA-mutation. Mitochondrial respiratory chain disorders (RCD) are a group of genetically and clinically heterogeneous diseases, due to the fact that protein components of the respiratory chain are encoded by both mitochondrial and nuclear genomes and are essential in all cells. In addition, the biogenesis, structure and function of mitochondria, including DNA replication, transcription, and translation, all require nuclear encoded genes. Since mitochondria are present in every cell, every tissue, mitochondrial disorders usually affects multiple organs. Mitochondrial Disorders Caused by Nuclear Genes discusses the biochemical, molecular, clinical, and genetic aspects of complex dual genome mitochondrial disorders. Chapters include genes involved in mitochondrial DNA biogenesis and maintenance of mitochondrial DNA integrity, complex subunits and assembly genes, and mitochondrial protein translation related diseases.
  • 1. Clinical Approach to the Diagnosis of Mitochondrial Disease / Dominic Thyagarajan, p. 1-23 -- 2. Mitochondrial DNA Mutations and Their Effects on Complex I Biogenesis: Implications for Metabolic Disease / Matthew McKenzie, p. 25-47 -- 3. Embryonic Stem Cells: A Signalling Perspective / Marios P. Stavridis, p. 49-68 -- 4. From Oocytes and Pluripotent Stem Cells to Fully Differentiated Fates: (Also) a Mitochondrial Odyssey / João Ramalho-Santos, Ana Sofia Rodrigues, p. 69-86 -- 5. From Pluripotency to Differentiation: The Role of mtDNA in Stem Cell Models of Mitochondrial Diseases / João Facucho-Oliveira, Tejal Kulkarni, p. 87-118 -- 6. The Role of Mitochondrial DNA in Tumorigenesis / Ka Yu Yeung, Adam Dickinson, p. 119-155 -- 7. Assisted Reproductive Technologies: The Potential to Prevent the Transmission of Mutant mtDNA from One Generation to the Next / Richard D. W. Kelly, Arsalan Mahmud, p. 157-183.
  • The Genetics of Mitochondrial Fusion and Fission -- Relationships Between Mitochondrial Dynamics and Bioenergetics -- no access69-108 Mitochondrial Dynamics and Autophagy -- Mitochondrial Dynamics and Apoptosis -- Mitochondrial Dynamics and Axonal Transport -- Neurological Diseases Associated with Mutations in the Mitochondrial Fusion Machinery -- Mitochondrial Fission-Fusion and Parkinson's Disease: A Dynamic Question of Compensatory Networks -- Role of the Mitochondrial Fission Protein Drp1 in Synaptic Damage and Neurodegeneration -- Mitochondrial Dynamics and Huntington's Disease: A Dance of Fate -- Back matter.
  • Pt. 1. Mitochondrial function and genetics -- pt. 2. Mitochondrial dysfunction : causes and effects? -- pt. 3. Functional consequences of mitochondrial dysfunction -- pt. 4. Modeling mitochondrial contribution to neurodegerative diseases -- pt. 5. The future.
  • Mitochondrial function 2014
  • Mitochondria, often referred to as the 'powerhouses' of the cell, generate adenosine triphosphate (ATP) by oxidative phosphorylation or OXPHOS, and maintain cellular homeostasis. In addition to generating ATP, mitochondria are involved in regulation of cell cycle, proliferation, free radical production, innate immune responses and apoptosis. Mitochondrial Function in Lung Health and Disease fills the current gap in the literature and outlines the growing clinical relevance of mitochondrial dysfunction. Currently, there is no overview on the role of mitochondria in pulmonary diseases and this volume focuses on the mitochondrial metabolism, redox signaling, and mechanisms of mitochondrial pathways in lung injury, inflammation, repair and remodeling. Furthermore, in addition to their well-recognized role in cellular energy production and apoptosis, mitochondria appear to play a role in many respiratory diseases and lung cancer. Chapters are written by top notch researchers and clinicians and outline the evidence for mitochondrial biogenesis in inhalational lung injury, COPD and asthma.
  • 1. Basic mitochondrial genetics, bioenergetics, and biogenesis -- 2. The Warburg phenomenon and other metabolic alterations of cancer cells -- 3. Mitochondrial control of apoptosis and cancer -- 4. Mitochondrial-to-nuclear communications in cancer -- 5. Types of mitochondrial genetic alterations in cancer -- 6. Mitochondrial genetic alterations in cancer I: skin, head and neck, salivary glands, thyroid, breast, lung, esophageal, gastric, colorectal, pancreatic, liver and gallbladder cancers -- 7. Mitochondrial genetic alterations in cancer II: renal, urinary bladder, prostate, ovarian, endometrial, cervical, nervous system, hemoatologic and connective tissue cancers -- 8. Mitochondrial genome rearrangement and copy number changes in cancer -- 9. Functional importance of mitochondrial genetic alterations in cancer -- 10. The role of mitochondrial reactive oxygen species in cancer -- 11. Mitochondrial DNA measurement in exfoliated cells for cancer detection and monitoring: the copy number advantage -- 12. Early cancer detection and monitoring using changes in the mitochondrial genome as biosensors -- 13. Analysis of mitochondrial genome alterations in cancer -- 14. "Mitocans": agents targeting mitochondria to kill cancer cells -- Index.
  • Introduction to Mitochondrial Oxidative Phosphorylation / Bernhard Kadenbach -- Mitochondrial Dynamics: The Intersection of Form and Function / Andrew Ferree and Orian Shirihai -- Biogenesis of Mitochondrial Proteins / Johannes M. Herrmann, Sebastian Longen, Daniel Weckbecker and Matthieu Depuydt -- Assembly Factors of Human Mitochondrial Respiratory Chain Complexes: Physiology and Pathophysiology / Daniele Ghezzi and Massimo Zeviani -- Supramolecular Organisation of the Mitochondrial Respiratory Chain: A New Challenge for the Mechanism and Control of Oxidative Phosphorylation / Giorgio Lenaz and Maria Luisa Genova -- Molecular Mechanisms of Superoxide Production by the Mitochondrial Respiratory Chain / Stefan Dröse and Ulrich Brandt -- Studies on the Function and Regulation of Mitochondrial Uncoupling Proteins / Richard K. Porter -- Evolution of the Couple Cytochrome c and Cytochrome c Oxidase in Primates / Denis Pierron, Derek E. Wildman, Maik Hüttemann, Thierry Letellier and Lawrence I. Grossman -- Reaction Mechanism of Mammalian Mitochondrial Cytochrome c Oxidase / Shinya Yoshikawa, Kazumasa Muramoto and Kyoko Shinzawa-Itoh -- Phosphorylation of Mammalian Cytochrome c and Cytochrome c Oxidase in the Regulation of Cell Destiny: Respiration, Apoptosis, and Human Disease / Maik Hüttemann, Icksoo Lee, Lawrence I. Grossman, Jeffrey W. Doan and Thomas H. Sanderson -- Individual Biochemical Behaviour Versus Biological Robustness: Spotlight on the Regulation of Cytochrome c Oxidase / Rabia Ramzan, Petra Weber, Bernhard Kadenbach and Sebastian Vogt -- Bigenomic Regulation of Cytochrome c Oxidase in Neurons and the Tight Coupling Between Neuronal Activity and Energy Metabolism / Margaret T. T. Wong-Riley -- Cytochrome c Oxidase and Its Role in Neurodegeneration and Neuroprotection / Susanne Arnold -- The Many Clinical Faces of Cytochrome c Oxidase Deficiency / Salvatore DiMauro, Kurenai Tanji and Eric A. Schon.
  • "This book examines a unique assembly of coordinated mitochondrial functions that are important in regulating cell function and are of relevance in a myriad of pathophysiological situations, such as age-related neurodegenerative disorders, cancer, metabolic syndrome, and cardiovascular disease. The text covers themes essential for the maintenance of mitochondrial activity, including electron transport and energy production, mitochondrial biogenesis and dynamics, mitochondrial signaling, and apoptosis and autophagy. The book features chapters that are reviews of the important topics covered and are written by an impressive cadre of internationally recognized scientist"--Provided by publisher.
  • Part I. Imaging of the mitral valve -- Part II. Congenital mitral and tricuspid disease -- Part III. Degenerative mitral valve disease -- Part IV. Ischemic mitral regurgitation -- Part V. Inflammatory mitral valve disease -- Part VI. Atlas of mitral and tricuspid annuloplasty rings -- Part VII. Acknowledgements -- Part VIII. Subject Index.
  • Surgical anatomy of the mitral and tricuspid valve -- Pathology and classification of mitral valve disease -- Chronic mitral regurgitation -- Chronic ischemic mitral regurgitation -- Asymptomatic mitral valve regurgitation: watchful wait or early repair?: review of the current evidence -- Mitral valve prosthesis insertion with preservation of the sub-valvar apparatus -- How I assess and repair the Barlow mitral valve: the respect rather than resect approach -- How I assess and repair the Barlow mitral valve: the edge-to-edge technique -- How I assess and repair the Barlow mitral valve -- Ischemic mitral regurgitation -- Minimally invasive mitral valve surgery -- Mitral stenosis -- Atrial fibrillation: non-surgical management -- Ablation of atrial fibrillation with cardiac surgery -- Tricuspid regurgitation: natural history, assessment, and intervention.
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    pt. A: Bk. 1. Foundations of internal medicine. Bk. 2. Cardiovascular medicine. Bk. 3. Gastroenterology and hepatology. Bk. 4 Rheumatology. Bk. 5. Neurology. Bk. 6. Hematology and oncology -- pt. B: Bk. 1. Infectious disease. Bk. 2. Pulmonary and critical care medicine. Bk. 3. General internal medicine. Bk. 4. Endocrinology and metabolism. Bk. 5. Nephrology. Bk. 6. Cumulative index.
  • Print Material
    [v.1] Cardiovascular medicine -- [v. 2] Gastroenterology and hepatology -- [v. 3] Hematology and oncology -- [v. 4] Neurology -- [v. 5] Rheumatology -- [v. 6] Dermatology -- [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative Index.
  • Print Material
    Part A -- [v. 1] Cardiovascular medicine -- [v. 2] Dermatology -- [v. 3] Gastroenterology and hepatology -- [v. 4] Hematology and oncology -- [v. 5] Neurology -- [v. 6] Rheumatology -- [v. 7] Endocrinology and metabolism -- [v. 8] General internal medicine -- [v. 9] Infectious disease -- [v. 10] Nephrology -- [v. 11] Pulmonary and critical care medicine -- [v. 12] Cumulative index.
  • Introduction -- International mobility as a process -- Factors contributing to mobility of health workers -- Countries, structures and systems -- Some notions about the European dimension -- Managing mobile health workforces? -- Conclusions, challenges and recommendations.
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    "The Ndlovu Care Group (NCG), a South African NGO, provides health care and community care for people living in a rural area of South Africa, in particular the Moutse area in Limpopo and Mpumalanga provinces. There are 120,000 to 150,000 beneficiaries. In a period of 15 years, Hugo Tempelman and co-workers developed an integrated model of care serving the broad health and community needs of poor people in an area where almost no medical and health care services are provided. This book describes a model for the advancement of rural areas in South Africa through community health and community care as developed by NCG. Over the years it became evident that this model could have an impact on the further advancement of rural areas in any developing country. NCG operates through two divisions, the Autonomous Treatment Centre (ATC) and the Community Health Awareness Mobilisation & Prevention (CHAMP) programme. The ATC is an extended community health centre that provides integrated primary health, TB and HIV/AIDS care and treatment, including maternal and reproductive health care and advanced HIV/AIDS in-patient care. The co-operation with governmental departments is described. The CHAMP programme consists of an AIDS awareness programme for schools, farms and local communities; programmes for vulnerable children because of e.g. HIV & AIDS infection, under- and malnourishment, disturbed family life, death of parents; a dental programme; art, culture and sports activities; all kinds of community activities, like a waste programme, a nappy factory and an IT training programme; and an environmental awareness and education programme. NCG has established its care model in two rural locations in South Africa, and is in the process of developing two more sites. To show the validity of its work, it also carries out monitoring & evaluation procedures and evidence-based research. Several chapters of this book testify to this scientific approach."--Back cover.
  • Malignant tumors due to breast cancer and masses due to benign disease appear in mammograms with different shape characteristics: the former usually have rough, spiculated, or microlobulated contours, whereas the latter commonly have smooth, round, oval, or macrolobulated contours. Features that characterize shape roughness and complexity can assist in distinguishing between malignant tumors and benign masses. In spite of the established importance of shape factors in the analysis of breast tumors and masses, difficulties exist in obtaining accurate and artifact-free boundaries of the related regions from mammograms. Whereas manually drawn contours could contain artifacts related to hand tremor and are subject to intra-observer and inter-observer variations, automatically detected contours could contain noise and inaccuracies due to limitations or errors in the procedures for the detection and segmentation of the related regions. Modeling procedures are desired to eliminate the artifacts in a given contour, while preserving the important and significant details present in the contour.
  • Introduction: Reminiscing on Models and Modeling / Robert B. Denman -- Probing Astrocyte Function in Fragile X Syndrome / Shelley Jacobs, Connie Cheng and Laurie C. Doering -- Neural Stem Cells / Maija Castrén -- Fragile X Mental Retardation Protein (FMRP) and the Spinal Sensory System / Theodore J. Price and Ohannes K. Melemedjian -- The Role of the Postsynaptic Density in the Pathology of the Fragile X Syndrome / Stefan Kindler and Hans-Jürgen Kreienkamp -- Behavior in a Drosophila Model of Fragile X / Sean M. McBride, Aaron J. Bell and Thomas A. Jongens -- Molecular and Genetic Analysis of the Drosophila Model of Fragile X Syndrome / Charles R. Tessier and Kendal Broadie -- Fragile X Mental Retardation Protein and Stem Cells / Abrar Qurashi, Xuekun Li and Peng Jin -- Manipulating the Fragile X Mental Retardation Proteins in the Frog / Marc-Etienne Huot, Nicolas Bisson, Thomas Moss and Edouard W. Khandjian -- Exploring the Zebra Finch Taeniopygia guttata as a Novel Animal Model for the Speech-Language Deficit of Fragile X Syndrome / Claudia Winograd and Stephanie Ceman -- Neuroendocrine Alterations in the Fragile X Mouse / Abdeslem El Idrissi, Xin Yan, William L'Amoreaux, W. Ted Brown and Carl Dobkin -- Taking STEPs Forward to Understand Fragile X Syndrome / Susan M. Goebel-Goody and Paul J. Lombroso -- Fmr-1 as an Offspring Genetic and a Maternal Environmental Factor in Neurodevelopmental Disease / Bojana Zupan and Miklos Toth -- Mouse Models of the Fragile X Premutation and the Fragile X Associated Tremor/Ataxia Syndrome / Michael R. Hunsaker, Gloria Arque, Robert F. Berman, Rob Willemsen and Renate K. Hukema -- Clinical Aspects of the Fragile X Syndrome / W. Ted Brown -- Fragile X Syndrome: A Psychiatric Perspective / Michael R. Tranfaglia -- Fragile X Syndrome and Targeted Treatment Trials / Randi Hagerman, Julie Lauterborn, Jacky Au and Elizabeth Berry-Kravis -- The Fragile X-Associated Tremor Ataxia Syndrome / Flora Tassone and Randi Hagerman -- Vignettes: Models in Absentia / Robert B. Denman.
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    Introduction to simple epidemic models -- Host heterogeneities -- Multi-pathogen / multi-host models -- Temporally forced models -- Stochastic dynamics -- Spatial models -- Controlling infectious diseases.
  • Phase transitions in single neurons and neural populations: Critical slowing, anesthesia, and sleep cycles -- Generalized state-space models for modeling nonstationary EEG time-series -- Spatiotemporal instabilities in neural fields and the effects of additive noise -- Spontaneous brain dynamics emerges at the edge of instability -- Limited spreading: How hierarchical networks prevent the transition to the epileptic state -- Bifurcations and state changes in the human alpha rhythm: Theory and experiment -- Inducing transitions in mesoscopic brain dynamics -- Phase transitions in physiologically-based multiscale mean-field brain models -- A continuum model for the dynamics of the phase transition from slow-wave sleep to REM sleep -- What can a mean-field model tell us about the dynamics of the cortex? -- Phase transitions, cortical gamma, and the selection and read-out of information stored in synapses -- Cortical patterns and gamma genesis are modulated by reversal potentials and gap-junction diffusion.
  • This practical introduction to molecular modelling of GPCRs covers core principles, and moves on to present advanced GPCR modelling techniques. Includes data on crystal structures and essential amino acid sequences, as well as LINUX commands and examples.
  • Progress in modelling malaria transmission -- Vector transmission heterogeneity and the population dynamics and control of lymphatic filariasis -- Modelling multi-species parasite transmission -- Metapopulation models in tick-borne disease transmission modelling -- Modelling stochastic transmission processes in helminth infections -- Modelling environmentally-mediated infectious diseases of humans: transmission dynamics of schistosomiasis in China -- Parameter estimation and site-specific calibration of disease transmission models -- Modelling malaria population structure and its implications for control -- Mathematical modelling of the epidemiology of tuberculosis -- Modelling trachoma for control programmes -- Transmission models and management of lymphatic filariasis elimination -- Disease transmission models for public health decision-making : designing intervention strategies for Schistosoma japonicum -- Modelling climate change and malaria transmission -- Modelling the transmission of Trypanosoma cruzi : the need for an integrated genetic epidemiological and population genomics approach.
  • How to separate conceptual issues from empirical ones in the study of consciousness / M. Velmans -- The disunity of consciousness / S. Zeki -- Consciousness: the radical plasticity thesis / A Cleeremans -- A higher order Bayesian decision theory of consciousness / H. C. Lau -- Subjective measures of unconscious knowledge / Z. Dienes -- Interdependence of attention and consciousness / N. Srinivasan -- Computational studies of consciousness / I. Aleksander, H. Morton -- Identification of neuroanatomical substrates of set-shifting ability: evidence from patients with focal brain lesions / P. Mukhopadhyay ... [et. al] -- Thinking is believing / R. Kasturirangan -- The emergence of mind and brain: and evolutionary, computational, and philosophical approach / K. Mainzer -- Dynamic geometry, brain function modeling, and consciousness / S. Roy, R. Llinás -- Understanding the mind of a worm: hierarchial network structure underlying nervous system function in C. elegans / N. Chatterjee, S. Sinha -- Neural network modeling / B.K. Chakrabarti, A. Basu -- Retinomorphic image processing / K. Ghosh, K. Bhaumik, S. Sarker -- Modeling the sub-cellualer signaling pathways involved in reinforcement learning at the straitum / S.M. Wanjerkhede, R.S. Bapi -- Rythmic structure of Hindi and English: new insights from a computational analysis / T. Das, L. Singh, N.C. Singh -- Empirical perspectives from the self-model theory of subjectivity: a brief summary with examples / T. Metzinger -- Vipassana: the Buddha's tool to probe mind and body / D.V. Chavan -- Buddha and the bridging relations / R. Banerjee.
  • Exacerbations of asthma and COPD: definitions, clinical manifestations, and epidemiology / O'Byrne, P.M. -- Human rhinovirus models in asthma / Singh, A.M., Busse, W.W. -- Allergen inhalation challenge: a human model of asthma exacerbation / Gauvreau, G.M., Evans, M.Y. -- Cellular and animals models for rhinovirus infection in asthma / Xatzipsalti, M., Papadopoulos, N.G. -- Modeling responses to respiratory house dust mite exposure / Cates, E.C. ... [et al.] -- Respiratory syncytial virus-induced pulmonary disease and exacerbation of allergic asthma / Lukacs, N.W. ... [et al.] -- Lipopolysaccharide challenge of humans as a model for chronic obstructive lung disease exacerbations / Kharitonov, S.A., Sjöbring, U. -- A human rhinovirus model of chronic obstructive pulmonary disease exacerbations / Contoli, M. ... [et al.] -- Animal models of cigarette smoke-induced chronic obstructive lung disease / Churg, A., Wright, J.L. -- Animal models of chronic obstructive pulmonary disease exacerbations / Gaschler, G.J. ... [et al.].
  • There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book series is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In Part 1, early models of saccades and smooth pursuit are presented. A number of oculomotor plant models are described therein beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th-order oculomotor plant model. In Part 2, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. In this book, a multiscale model of the saccade system is presented, focusing on the neural network. Chapter 1 summarizes a whole muscle model of the oculomotor plant based on the 2009 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. Chapter 2 presents a neural network model of biophysical neurons in the midbrain for controlling oculomotor muscles during horizontal human saccades. To investigate horizontal saccade dynamics, a neural circuitry, including omnipause neuron, premotor excitatory and inhibitory burst neurons, long lead burst neuron, tonic neuron, interneuron, abducens nucleus, and oculomotor nucleus, is developed. A generic neuron model serves as the basis to match the characteristics of each type of neuron in the neural network. We wish to express our thanks to William Pruehsner for drawing many of the illustrations in this book.
  • There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, early models of saccades and smooth pursuit are presented. The smooth pursuit system allows tracking of a slow moving target to maintain its position on the fovea. Models of the smooth pursuit have been developed using systems control theory, all involving a negative feedback control system that includes a time delay, controller and plant in the forward loop, with unity feedback. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The oculomotor plant consists of three muscle pairs and the eyeball. A number of oculomotor plant models are described here beginning with the Westheimer model published in 1954, and up through our 1995 model involving a 4th order oculomotor plant model. The work presented here is not an exhaustive coverage of the field, but focused on the interests of the author. In Part II, a state-of-art model of the saccade system is presented, including a neural network that controls the system.
  • There are five different types of eye movements: saccades, smooth pursuit, vestibular ocular eye movements, optokinetic eye movements, and vergence eye movements. The purpose of this book is focused primarily on mathematical models of the horizontal saccadic eye movement system and the smooth pursuit system, rather than on how visual information is processed. A saccade is a fast eye movement used to acquire a target by placing the image of the target on the fovea. Smooth pursuit is a slow eye movement used to track a target as it moves by keeping the target on the fovea. The vestibular ocular movement is used to keep the eyes on a target during brief head movements. The optokinetic eye movement is a combination of saccadic and slow eye movements that keeps a full-field image stable on the retina during sustained head rotation. Each of these movements is a conjugate eye movement, that is, movements of both eyes together driven by a common neural source. A vergence movement is a non-conjugate eye movement allowing the eyes to track targets as they come closer or farther away. In this book, a 2009 version of a state-of-the-art model is presented for horizontal saccades that is 3rd-order and linear, and controlled by a physiologically based time-optimal neural network. The oculomotor plant and saccade generator are the basic elements of the saccadic system. The control of saccades is initiated by the superior colliculus and terminated by the cerebellar fastigial nucleus, and involves a complex neural circuit in the mid brain. This book is the second part of a book series on models of horizontal eye movements.
  • Natural SIV infection : virological aspects / Jan Münch and Frank Kirchhoff -- Natural SIV infection : immunological aspects / Béatrice Jacquelin, Roland C. Zahn, Françoise Barré-Sinoussi, Jörn E. Schmitz, Amitinder Kaur and Michaela C. Müller-Trutwin -- Implications for therapy / Ivona Pandrea and Alan L. Landay -- Are some people protected against HIV infection? / Mario Clerici, Mara Biasin and Gene M. Shearer -- The genital mucosa, the front lines in the defense against HIV / T. Blake Ball and Kristina Broliden -- Host genetics and resistance to HIV-1 infection / Ma Luo, Paul J. McLaren and Francis A. Plummer -- The immune system and resisting HIV infection / Keith R. Fowke, Catherine M. Card and Rupert Kaul -- Definition, natural history and heterogeneity of HIV controllers / Asier Sáez-Cirión, Gianfranco Pancino and Olivier Lambotte, for the ANRS CO18 Cohort -- Residual viremia and viral reservoirs in elite controllers / Robert W. Buckheit III and Joel N. Blankson -- Immune responses associated to viral control / Florencia Pereyra and Bruce D. Walker -- Immune mechanisms of viral control in HIV-2 infection / Eirini Moysi, Thushan de Silva and Sarah Rowland-Jones -- Genetic associations with resistance to HIV-1 infection, viral control and protection against disease / Jacques Fellay and Amalio Telenti.
  • The woodchuck: a model for immunopathogenesis and therapy of hepadnaviral infection / Roggendorf, M., Lu, M. -- Pathogenesis of hepatitis B virus in transgenic mice / Sitia, G. ... [et al.] -- Transfer of HBV genomes into mice / Oberwinkler, H. ... [et al.] -- Recent advances in the duck hepatitis B virus model of human hepatitis B virus infection / Jilbert, A.R. -- Determinants of hepadnaviral species and liver cell tropism / Funk, A. ... [et al.] -- T-cell response to hepatitis B virus and hepatitis C virus: lessons learned from the chimpanzee model / Thimme, R. ... [et al.] -- The replicon system as an efficient tool to study HCV RNA replication / Lohmann, V. -- Hepatitis B virus infection of primary tupaia hepatocytes / Kück, J., Glebe, D. -- Tupaia belangeri as a model for hepatitis C virus infection / Baumert, T. ... [et al.] -- Primary human hepatocytes as an in vitro model for hepatitis B virus infection / Boehm, S. ... [et al.] -- Progress and perspectives of the uPA/RAG-2 mouse model: liver repopulation and viral infection studies / Dandri, M. ... [et al.] -- The trimera mouse model of HBV and HCV infection / Bücher, W.O., Reisner, Y.
  • An overview of psoriasis / M. Alan Menter -- Evaluating psoriasis in patients / John Y. M. Koo, Jonathan W. Kowalski, Mark G. Lebwohl, Chris M. Kozma, M. Alan Menter, and Charles N. Ellis -- Topical agents / Rosemary deShazo, Gerald G. Krueger, and Kristina Callis Duffin -- The art and practice of UVB phototherapy and lasers / Monica Huynh, Maya G. Debbaneh, Ethan Levin, and John Y. M. Koo -- Systemic and topical PUVA therapy / Warwick L. Morison and Elizabeth G. Richard -- Goeckerman therapy / Rishu Gupta and John Y. M. Koo -- Combination, rotational, and sequential therapies / Jason Emer and Mark G. Lebwohl -- Systemic retinoids / Daniel Butler, Tina Bhutani, Ethan Levin, Eva Wang, and John Y. M. Koo -- Methotrexate / Gerald D. Weinstein and Edward W.B. Jeffes III -- Cyclosporine / Ethan Levin and Charles N. Ellis -- Etanercept / Shannon Famenini, Erik Y. Sako, Daniel C. Butler, and Jashin J. Wu -- Adalimumab / Maya G. Debbaneh and John Y. M. Koo -- Ustekinumab / Andrew Blauvelt -- Infliximab / Ethan Levin, John Y. M. Koo, and Alice Gottlieb -- Biologic fatigue / Ethan Levin and John Y. M. Koo -- IL-17 and other new agents / Ethan Levin, Argentina Leon, and John Y. M. Koo -- Erythrodermic and pustular psoriasis / Ethan Levin, Erik Y. Sako, Shannon Famenini, and Jashin J. Wu -- Pediatric psoriasis / Lauren Becker, Kelly M. Cordoro, Amy S. Paller -- Psoriatic arthritis / Dafna D. Gladman -- Special patient populations / Daniel C. Butler, Faranak Kamangar, Ethan Levin, John Y. M. Koo, and Anne S. Chang -- Current and potential applications of pharmacogenetics and pharmacogenomics / Rishu Gupta, Wilson Liao, John Y. M. Koo, and Jashin J. Wu -- The immunomodulatory/immunosuppressive classification system / John Y. M. Koo.
  • Modern anesthetics 2008
  • Preface -- [1]. Introduction -- 2. General aspects -- 3. Stability of complexes -- 4. Lanthanide and macrocyclic complexes -- 5. Structural chemistry of lanthanide complexes -- 6. Organometallic complexes -- 7. Kinetics and mechanisms of rare earth complexation -- 8. Spectroscopy of lanthanide complexes -- 9. Photoelectron spectroscopy of rare earths -- 10. Lanthanide NMR shift reagents -- 11. Environmental, ecological, biological aspects -- 12. Applications -- Subject index.
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    Red cell and platelet preservation: historical perspectives, review of metabolism, and current trends -- Basic genetics for blood bankers -- Fundamentals of immunology for blood bankers -- Concepts in molecular biology -- The antiglobulin test -- The ABO blood group system -- The RH blood group system -- The Lewis system and the biological significance -- Other major blood group systems -- The red cell surface antigen terminology and miscellaneous blood groups donor screening and component preparation -- Donor screening and component preparation -- Detection and identification of antibodies -- Pretransfusion compatibility testing -- Orientation to the modern blood bank laboratory -- Alternative technologies and automation in routine blood bank testing -- Transfusion therapy and transfusion in transplantation -- Apheresis -- Adverse effects of blood transfusion -- Transfusion-transmitted diseases -- Hemolytic disease of the newborn and fetus -- Autoimmune hemolytic anemias -- The HLA system -- Parentage testing -- Quality management in the blood bank -- Transfusion safety and federal regulatory requirements -- Informational systems in the blood bank -- Medicolegal and ethical aspects of providing blood collection and transfusion services.
  • Topical anaesthesia for small incision cataract surgery / Bellucci, R. -- Why viscoadaptives? Are they really new? / Arshinoff, S.A. -- Comparison of four visocelastic substances for cataract surgery in eyes with cornea guttata / Mester, U.; Hauck, C.; Anterist, N.; Löw, M. -- The Staar wave / Fine, I.H.; Hoffman, R.S.; Packer, M. -- Phacotmesis / Kamman, J.; Dornbach, G. -- Tilt and tumble phacoemulsification / Davis, E.A.; Lindstrom, R.L. -- Phacoemulsification in the anterior chamber: preliminary results / Alio,́ J.L.; Shalaby, A.M.M.; Attia, W.H.-- Phaco chop: making the transition / Friedman, N.M.; Kohnen, T.; Koch, D.D. -- Ultrasound-assisted phaco aspiration / Olson, R.J. -- Management of the mature cataract / Masket, S. -- Phacoemulsification in the vitreous cavity / Ruiz-Moreno, J.M.; Alio,́ J.L. -- Capsular tension ring as adjuvant in phacoemulsification surgery / Munõz, G.; Alio,́ J.L.-- Optical coherence biometry / Haigis, W.-- Optical biometry in cataract surgery / Findl, O. et al -- White-to-white corneal diameter measurements using the eyemetrics program of the Orbscan Topography Systems / Wang, L.; Auffarth, G.U.-- Injector systems for foldable intraocular lens implantation / Fabian, E.-- Incisions for implantation of fordable intraocular lenses / Kohnen, T.-- Scheimpflug imaging of modern foldable high-refractive silicone and hydrophobic acrylic intraocular lenses / Baumeister, M.; Buḧren, J.; Kohnen, T.-- Does the PCO preventing square edge concept apply to acrylic-hydrophilic intraocular lenses? / Jaullery, S.; Sourdille, P.-- Posterior capsule opacification after implantation of polyfluorocarbon-coated intraocular lenses: a long term follow-up / Auffarth, G.U. et al -- Piggyback intraocular lens implantation / Gills, J.P.; Fenzl, R.E.-- Multifocal intraocular lenses / Claoue,́ C.; Parmar, D.
  • Part 1. Current Molecular Laboratory Methods -- Specimen Collection, Handling, and Processing / Lindsy Hengesbach and John A. Gerlach -- DNA/RNA Isolation and Quantitation / Jing Wang -- Test Validation / Cindy McCloskey and S. Terence Dunn -- In Vitro Amplification Methods in Molecular Diagnostics / C. Alexander Valencia and Bradford Coffee -- Whole Genome Sequencing in the Clinical Laboratory / Tina Hambuch, Brad Sickler, Arnold Liao, Suneer Jain and Philip D. Cotter -- Estimation of Exon Dosage Using Real-Time Quantitative Polymerase Chain Reaction / Applications to Factor VIII Gene in Hemophilia A and Endoglin/ACVRL1 Genes in Hereditary Hemorrhagic Telangiectasia / Juliana Purrazzella and Arupa Ganguly -- Reporting Clinical Molecular Genetic Laboratory Results / Victor Wei Zhang and Lora J. H. Bean -- Part 2. Clinical Molecular Infectious Disease Testing -- HIV-1 Genotyping and Virtual Phenotyping / Fangling Xu and Jianli Dong -- COBAS® AmpliPrep/COBAS® TaqMan® HIV-1 Test, Version 2.0 / Tavat A. Buraruk and Charles E. Stager -- Hepatitis C Virus (HCV) Genotype Assay (LiPA) / Charles E. Stager and Tavat A. Buraruk -- COBAS® AmpliPrep/COBAS® TaqMan® HCV Test / Charles E. Stager and Tavat A. Buraruk -- Epstein-Barr Virus and Cytomegalovirus Viral Load Monitoring by Quantitative Real-Time Polymerase Chain Reaction / Su S. Chen, Seema Hai, Margaret L. Gulley and Rajyalakshmi Luthra -- Quantification of BK Viral Load / Hai Wu and Jianli Dong -- Molecular Diagnosis and Epidemiology of Rabies / Rodney E. Rohde and Bonny C. Mayes -- Pyrosequencing for Bacterial Identification / Laura Millecker and Ruth Ann Luna -- Other Pathogens of Significant Public Health Concern / Chris L. McGowin, Rodney E. Rohde and Greg C. Whitlock -- Part 3. Clinical Molecular Oncology Testing -- Gene Rearrangements Testing / Siby Sebastian, Juan Du and Rizwan Naeem -- Mutation Analysis in Cancer / Keyur Pravinchandra Patel, John Galbincea and Rajyalakshmi Luthra -- Minimal Residual Disease / Wesley O. Greaves and Rajyalakshmi Luthra -- Pyrosequencing in Cancer / Shalini Verma, Bedia A. Barkoh and Rajyalakshmi Luthra -- Clinical Applications of Microarrays in Cancer / Marilyn M. Li, Ankita Patel and Xiaofeng Hu -- Basic Theories and Clinical Applications of Molecular Flow Cytometry / Hua-Kang Wu, Hongli Chen and Peter C. Hu -- Part 4. Clinical Molecular Pre/Postnatal Testing -- Molecular Prenatal Diagnostic Testing / Joanna Wiszniewska and Christine M. Eng -- PCR Based Diagnosis of Fragile X Syndrome / Daniel J. Dykas and Allen E. Bale -- Part 5. Human Identity Testing -- Microsatellite Testing Short Tandem Repeat Profile Generation / Robin DeVille Guidry and Laura Gahn -- Parentage / Laura Gahn and Robin DeVille Guidry -- Part 6. Clinical Molecular Training -- Diagnostic Molecular Training / Peter C. Hu, Patrick Alan Lennon and Madhuri R. Hegde -- Molecular Diagnostics Point of Care Testing Training / Chang W. Lee and Peter C. Hu.
  • This volume covers classic as well as cutting-edge topics on the analysis of clinical trial data in biomedical and psychosocial research and discusses each topic in an expository and user-friendly fashion. Starting with survival data analysis, this book transitions from such a classic topic to modern issues by stepping through diagnostic test and instrument assessment, sequential and dynamic treatment regimen, cost-effectiveness evaluation, equivalence testing. As some type of cancer such as the effect of smoking on lung cancer cannot be studied using randomized trials, a chapter on analysis of non-randomized studies is also included. The book concludes with a chapter discussing the opportunities and challenges that lie ahead in developing on person-centered treatment regimens. The book provides an overview of the primary statistical and data analytic issues associated with each of the selected topics, followed by a discussion of approaches for tackling such issues and available software packages for carrying out the analyses. Medical researchers with some background in clinical trial design and regression analysis as well as biostatisticians will find this book informative and helpful.
  • Recognized as an essential component of Chinese culture, Traditional Chinese Medicine (TCM) is both an ancient medical system and one still used widely in China today. TCM's independently evolved knowledge system is expressed mainly in the Chinese language and the information is frequently only available through ancient classics and confidential family records, making it difficult to utilize. The major concern in TCM is how to consolidate and integrate the data, enabling efficient retrieval and discovery of novel knowledge from the dispersed data. Computational approaches such as data mining, semantic reasoning and computational intelligence have emerged as innovative approaches for the reservation and utilization of this knowledge system. Typically, this requires an inter-disciplinary approach involving Chinese culture, computer science, modern healthcare and life sciences. This book examines the computerization of TCM information and knowledge to provide intelligent resources and supporting evidences for clinical decision-making, drug discovery, and education. Recent research results from the Traditional Chinese Medicine Informatics Group of Zhejiang University are presented, gathering in one resource systematic approaches for massive data processing in TCM. These include the utilization of modern Semantic Web and data mining methods for more advanced data integration, data analysis and integrative knowledge discovery. This book will appeal to medical professionals, life sciences students, computer scientists, and those interested in integrative, complementary, and alternative medicine. Interdisciplinary book bringing together Traditional Chinese Medicine and computer scientists. Introduces novel network technologies to Traditional Chinese Medicine informaticsProvides theory and practical examples and case studies of new techniques.
  • Western diet and behavior: the Columbus concept -- The social context of dietary behaviors: the role of social relationships and support on dietary fat and fiber intake -- Social class, food intakes and risk of coronary artery disease in the developing world: the Asian paradox -- Social, cultural, economical, and practical factors -- Partially hydrogenated fats in the US diet and their role in disease -- Fatty acid ratios in free-living and domestic animals -- Is saturated fat bad? -- Alteration of human body composition and tumorigenesis by isomers of conjugated linoleic acid -- Insulin resistance and non-alcoholic fatty liver disease induced by conjugated linoleic acid in humans -- Dietary fat intake: promotion of disease in carotid artery disease: lipid lowering versus side effects of statins -- Recent cholesterol-lowering drug trials: new data, new questions -- Leptin and obesity: role in cardiac structure and dysfunction -- Cardiac structural and functional changes in genetically modified models of obesity -- Fat-modified dairy products and blood lipids in humans -- Modified milk fat reduces plasma triacylglycerol concentrations: health and disease effects -- Dietary supplements, cholesterol and cardiovascular disease -- Ill health effects of food lipids: consequences of inadequate food processing, storage and cooking -- Mycotoxins in human diet: a hidden danger -- Nutrition-toxicological dilemma on fish consumption -- Anthropogenic and naturally produced contaminants in fish oil: role in ill health -- Do modern Western diets play a role in myalgic encephalomyelitis? -- The role of modern Western diets in Attention-Deficit Hyperactivity Disorder -- The role of dietary rat in insulin resistance and type 2 diabetes -- Strategies to modify school-based foods to lower obesity and disease risk -- Selenium enigma: health implications of an inadequate supply -- Homocysteine: role in cardiovascular disease -- Dietary plant extracts to modify effects of high fat modern diets in health promotion -- Don't diet: adverse effects of the weight centered health paradigm -- Physical activity in diet-induced disease causation and prevention in women and men.
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    Introduction / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Section I: Basic concepts -- Causation and causal inference / Kenneth J. Rothman ... [et al.] -- Measures of occurrence / Sander Greenland and Kenneth J. Rothman -- Measures of effect and measures of association / Sander Greenland, Kenneth J. Rothman, and Timothy L. Lash -- Concepts of interaction / Sander Greenland, Timothy L. Lash, and Kenneth J. Rothman -- Section II: Study design and conduct -- Types of epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Cohort studies / Kenneth J. Rothman and Sander Greenland -- Case-control studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Validity in epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Precision and statistics in epidemiologic studies / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Design strategies to improve study accuracy / Kenneth J. Rothman, Sander Greenland, and Timothy L. Lash -- Causal diagrams / M. Maria Glymour and Sander Greenland -- Section III: Data analysis -- Fundamentals of epidemiologic data analysis / Sander Greenland and Kenneth J. Rothman -- Introduction to categorical statistics / Sander Greenland and Kenneth J. Rothman -- Introduction to stratified analysis / Sander Greenland and Kenneth J. Rothman -- Applications of stratified analysis methods / Sander Greenland -- Analysis of polytomous exposures and outcomes / Sander Greenland -- Introduction to bayesian statistics / Sander Greenland -- Bias analysis / Sander Greenland and Timothy L. Lash -- Introduction to regression models / Sander Greenland -- Introduction to regression modeling / Sander Greenland -- Section IV: Special topics -- Surveillance / James W. Buehler -- Using secondary data / Jørn Olsen -- Field methods in epidemiology / Patricia Hartge and Jack Cahill -- Ecologic studies / Hal Morgenstern -- Social epidemiology / Jay S. Kaufman -- Infectious disease epidemiology / C. Robert Horsburgh, Jr., and Barbara E. Mahon -- Genetic and molecular epidemiology / Muin J. Khoury, Robert Millikan, and Marta Gwinn -- Nutritional epidemiology / Walter C. Willett -- Environmental epidemiology / Irva Hertz-Picciotto -- Methodologic issues in reproductive epidemiology / Clarice R. Weinberg and Allen J. Wilcox -- Clinical epidemiology / Noel S. Weiss -- Meta-analysis / Sander Greenland and Keith O'Rourke.
  • Basic biology of hemopoiesis / Reinhold Munker -- Molecular biology and cytokines / Reinhold Munker and Amanda Sun -- Supportive care in hematology / John Hiemenz and Reinhold Munker -- Transplantation of stem cells from bone marrow, peripheral blood and the umbilical cord / Ronald Paquette and Reinhold Munker -- Anemias: general considerations, microcytic, and megaloblastic anemias / Reinhold Munker -- Hemolytic anemias / Reinhold Munker ... [et al.] -- Leukocytosis, leukopenia, and other reactive changes of myelopoiesis / Reinhold Munker -- The myeloproliferative syndromes / Ronald Paquette, Erhard Hiller, and Reinhold Munker -- Acute myelogenous leukemias / Reinhold Munker -- Acute lymphoblastic leukemias / Reinhold Munker and Vishwas Sakhalkar -- Myelodysplastic syndromes / Ronald Paquette and Reinhold Munker -- Aplastic anemias / Ronald Paquette and Reinhold Munker -- Lymphocytosis, lymphopenia, lymphadenopathy, and splenomegaly / Reinhold Munker -- Hodgkin's lymphoma / Erhard Hiller and Reinhold Munker -- The non-Hodgkin's lymphomas / Reinhold Munker ... [et al.] -- Multiple myeloma and related paraproteinemias / Jonathan Glass and Reinhold Munker -- Congenital and acquired immunodeficiencies / Vishwas Sakhalkar and Reinhold Munker -- Infections relevant to hematology / Reinhold Munker -- Basic principles of hemostasis / Erhard Hiller -- Bleeding disorders / Erhard Hiller -- Thrombophilia, thromboembolic disease, and antithrombic therapy / Erhard Hiller -- Transfusion medicine and immunohematology / Grace C. Tenorio, Snehalata C. Gupte, and Reinhold Munker -- Storage disorders in hematology / Reinhold Munker.
  • Development perspectives / Derek J.W. McMinn -- Materials and metallurgy / Tim J. Band -- Machining processes / Roger W.F. Ashton -- Hip joint tribology / Amir Kamali -- Corrosion and its contribution to metal release / Joseph Daniel and Amir Kamali -- Retrieval analysis / Tim J. Band, Roger W.F. Ashton, and Amir Kamali -- Cementing technique in Birmingham Hip Resurfacing / Stephen McMahon and Gabrielle Hawdon -- Migration studies / Arne Lundberg and Raed Itayem -- Vascularity of the femoral head in hip resurfacing / Stephen McMahon and Gabrielle Hawdon -- Femoral head blood supply studies / Nobuhiko Sugano, Takashi Nishii, and Takehito Hananouchi -- Acetabular bone conservation / Joseph Daniel, Hena Ziaee, and Derek J.W. McMinn -- Femoral DEXA studies in hip arthroplasty / Nobuhiko Sugano -- Metal ions / Joseph Daniel and Hena Ziaee -- Patient selection and timing of operation / Joseph Daniel, Chandra Pradhan, and Hena Ziaee -- Anesthesia, pain control, and thromboprophylaxis / Jonathan W. Freeman -- Anesthesia with special emphasis on pain control / Dennis R. Kerr and Lawrence Kohan -- Templating for the Birmingham Hip Resurfacing from conventional X-rays / Derek J.W. McMinn -- Computer templating of hip resurfacing arthroplasty / James Slover, Erik Wetter, and Henrik Malchau -- Partient positioning and exposure / Derek J.W. McMinn -- Acetabular preparation and insertion of the standard Birmingham Hip Resurfacing cup / Derek J.W. McMinn -- Acetabular preparation and insertion of the dysplasia Birmingham Hip Resurfacing cup / Derek J.W. McMinn -- Implantation of the femoral component of the Birmingham Hip Resurfacing / Derek J.W. McMinn -- Birmingham mid-head resection prosthesis and its implantation / Derek J.W. McMinn -- Guides, jigs, and navigation-assisted Birmingham Hip Resurfacing / Derek J.W. McMinn -- Management of complex anatomy / Joseph Daniel ... [et al.] -- Outcomes and standards for hip resurfacing / Callum W. McBryde and Paul B. Pynsent -- Results of Birmingham Hip Resurfacing in different diagnoses / Joseph Daniel ... [et al.] -- Complications and revisions of the Birmingham Hip Resurfacing / Chandra Pradhan, Joseph Daniel, and Hena Ziaee -- Rehabilitation after the Birmingham Hip Resurfacing / Anne Hands, Hena Ziaee, and Chandra Pradhan -- Recovery and rehabilitation / Lawrence Kohan and Dennis R. Kerr -- Final thoughts / Derek J.W. McMinn and James W. Pritchett.
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  • Part 1. Challenges -- The Global Burden of Infectious Diseases / Paulo Pinheiro, Colin D. Mathers and Alexander Krämer -- Global Challenges of Infectious Disease Epidemiology / Alexander Krämer and Md. Mobarak Hossain Khan -- Emerging and Re-emerging Infectious Diseases / Thomas Löscher and Luise Prüfer-Krämer -- Infectious Disease Control Policies and the Role of Governmental and Intergovernmental Organisations / Gérard Krause -- Part 2. General concepts and methods -- Principles of Infectious Disease Epidemiology / Alexander Krämer, Manas Akmatov and Mirjam Kretzschmar -- Social Risk Factors / Klaus Krickeberg and David Klemperer -- Molecular Typing and Clustering Analysis as a Tool for Epidemiology of Infectious Diseases / Sylvia M. Bruisten and Leo Schouls -- Epidemiologic Surveillance / Ralf Reintjes and Klaus Krickeberg -- Outbreak Investigations / Ralf Reintjes and Aryna Zanuzdana -- Geographic Information Systems / Patrick Hostert and Oliver Gruebner -- Methods and Concepts of Epidemiology / Rafael Mikolajczyk -- Mathematical Models in Infectious Disease Epidemiology / Mirjam Kretzschmar and Jacco Wallinga -- Immunity to Infectious Diseases / Timo Ulrichs -- Principles and Practice of Vaccinology / Richard Pebody and Mirjam Kretzschmar -- Health Economics of Infectious Diseases / Robert Welte, Reiner Leidl, Wolfgang Greiner and Maarten Postma -- Part 3. Epidemiology of particular infectious diseases -- Airborne Transmission: Influenza and Tuberculosis / Timo Ulrichs -- Infectious Childhood Diarrhea in Developing Countries / Charles P. Larson, Lars Henning, Stephen Luby and Asg Faruque -- Bloodborne and Sexual Transmission: HIV/AIDS / Charlotte van den Berg, Karen Lindenburg and Roel Coutinho -- Blood Borne and Sexual Transmission: Hepatitis B and C / Freke Zuure, Susan Hahné, Thijs van de Laar, Maria Prins and Jim van Steenbergen -- Sexual Transmission: Chlamydia trachomatis / Robert E. Johnson and Stuart M. Berman -- Vector-Borne Transmission: Malaria, Dengue, and Yellow Fever / Tomas Jelinek -- Nosocomial Transmission: Methicillin-Resistant Staphylococcus aureus (MRSA) / M.J.M. Bonten and M.C.J. Bootsma -- Infectious Diseases and Cancer: HPV / Helen Trottier and Eduardo L. Franco.
  • Entropies, characterizations, applications and some history / János Aczél -- Belief function theory on the continuous space with an application to model based classification / B. Ristic and Ph. Smets -- Independence in conditional possibility theory / G. Coletti and B. Vantaggi -- Joint treatment of imprecision and randomness in uncertainty propagation / C. Baudrit, D. Dubois, D. Guyonnet and H. Fargier -- Consistency of probabilistic transformations of belief functions / M. Daniel -- Randomization and uncertain inference / Henry E. Kyburg, Jr. and Choh Man Teng -- An empirical complexity study for a 2CPA solver / M. Baioletti, A. Capotorti and S. Tulipani -- Consistency in preference modelling / José Luis García-Lapresta and Javier Montero -- Transitive decomposition of min-transitive fuzzy relations / S. Díaz, B. De Baets and S. Montes -- Decision making with fuzzy ternary relations / S. Ovchinnikov -- New consistency properties for preference relations / F. Chiclana, E. Herrera-Viedma and F. Herrera -- Management of uncertainty orderings through ASP / Andrea Capotorti and Andrea Formisano -- Automating the quality assurance of an on-line knowledge-based classifier by fusing multiple off-line classifiers / Piero P. Bonissone -- Qualitative classification with possibilistic decision trees / Nahla Ben Amor, Salem Benferhat and Zied Elouedi -- Discovery of abstract knowledge from non-atomic attribute values in fuzzy relational databases / Rafal A. Angryk and Frederick E. Petry -- Kernel-based outlier preserving clustering with representativity coefficients / M.-J. Lesot -- Fuzzy C-medoids clustering models for time-varying data / R. Coppi, P. D'Urso and P. Giordani -- Improving the K2 algorithm using association rule parameters / Evelina Lamma, Fabrizio Riguzzi and Sergio Storari -- OWA aggregation on an interval argument / Ronald R. Yager -- On bi-capacity-based concordance rules in multicriteria decision making / A. Rolland -- Information evaluation in fusion : formalization of informal recommendations / Laurence Cholvy -- Application of uncertainty-based methods to fuse language identification expert decisions / J. Gutiérrez, J.-L. Rouas and R. André-Obrecht -- Intelligent multiattribute decision support model for medical triage / F. Burstein, Jocelyn San Pedro, Leonid Churilov and Jeff Wassertheil -- Interval-based multicriteria decision making / Martine Ceberio and François Modave -- A linguistic hierarchical evaluation model for engineering systems / L. Martínez, L.G. Pérez, J. Liu, J.B. Yang and F. Herrera -- Non monotonic aggregates applying to fuzzy sets in flexible querying / Patrick Bosc and Ludovic Liétard -- Fuzzy spatial data modeling : an extended bitmap approach / Jörg Verstraete, Guy De Tré and Axel Hallez -- Introducing [lambda]-specialization into the fuzzy EER model / Guoqing Chen, Ling Lin and Xunhua Guo -- A logical reasoning framework for modelling and merging uncertain semi-structured information / Anthony Hunter and Weiru Liu -- Machine learning and the prediction of protein structure : the state of the art / Rita Casadio, Remo Calabrese, Emidio Capriotti, Mario Compiani, Piero Fariselli, Paola Marani, Ludovica Montanucci, Pier Luigi Martelli, Ivan Rossi and Gianluca Tasco -- Efficient and robust global amino acid sequence alignment with uncertain evolutionary distance / Matthias C.M. Troffaes -- Classifying biomedical spectra using stochastic feature selection and parallelized multi-layer perceptrons / N.J. Pizzi, R.L. Somorjai and W. Pedrycz -- On the sensitivity of probabilistic networks to reliability characteristics / Linda C. van der Gaag and Silja Renooij -- Dominance of recognition of words presented on right or left eye (comparison of kanji and hiragana) / Takahiro Yamanoi, Toshimasa Yamazaki, Jean-Louis Vercher, Elie Sanchez and Michio Sugeno -- Hand posture recognition with the fuzzy glove / T. Allevard, E. Benoit and L. Foulloy -- Image retrieval by composition of regions / J.F. Omhover and M. Detyniecki -- Blind image restoration from multiple views by IMAP estimation / Monia Discepoli, Ivan Gerace and Roberta Pandolfi -- A combined feature extraction method for an electronic nose / I. Hristozov, B. Iliev and S. Eskiizmirliler.
  • Applications in chemistry, biological and marine sciences. pt. 1, [1-3] -- Applications in medical and pharmaceutical sciences. pt. 2, [4-5] -- Applications in materials science and food science. pt. 3, [6-7].
  • Confounding and causal path diagrams -- Statistical modelling of partially observed data using multiple imputation: principles and practice -- Measurement errors in epidemiology -- Selection bias in epidemiologic studies -- Multilevel modelling -- Modelling data that exhibit an excess number of zeros : zero-inflated models and generic mixture models -- Multilevel latent class modelling -- Bayesian bivariate disease mapping -- Multivariate random fraility effects model for multiple spatially dependent survival data -- Meta-analysis of observational studies -- Directed acyclic graphs and structural equation modelling -- Latent growth curve models -- Growth mixture modelling for life course epidemiology -- G-estimation for accelerated failure time models -- Generalised additive models -- Regression and classification trees -- Statistical interactions and gene-environment joint effects.
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  • Genome-Scale Analysis of Data from High-Throughput Technologies / Sarah J. Wheelan -- Analysis of Inherited and Acquired Genetic Variation / Srinivasan Yegnasubramanian and William B. Isaacs -- Examining DNA-Protein Interactions with Genome-Wide Chromatin Immunoprecipitation Analysis / Esteban Ballestar and Manel Esteller -- Genome-Wide DNA Methylation Analysis in Cancer Research / Srinivasan Yegnasubramanian and William G. Nelson -- Use of Expression Microarrays in Cancer Research / Jun Luo and Yidong Chen -- Signal Sequencing for Gene Expression Profiling / Biaoyang Lin, Jeremy Wechsler and Leroy Hood -- Mass Spectrometry Based Proteomics in Cancer Research / Mohamad A. Abbani, Parag Mallick and Maryann S. Vogelsang -- Tissue Microarrays in Cancer Research / Toby C. Cornish and Angelo M. De Marzo.
  • Part I. Specific Dietary Components -- A. Major dietary constituents -- B. Minerals -- C. Vitamins -- D. Other compounds with health relevance -- Part II. Nutritional Roles in Integrated Biological Systems -- A. Nutrient-gene mechanisms -- B. Digestive, endocrine, immune, and neural mechanisms -- Part III. Nutritional Needs and Assessment During the Life Cycle and Physiologic Changes -- Part IV. Prevention and Management of Disease -- A. Obesity and diabetes -- B. Cardiovascular diseases -- C. Pediatric and adolescent disorders -- D. Disorders of the alimentary tract -- E. Nutritional management during cancer -- F. Skeletal and joint disorders -- G. Nutrition in surgery and trauma -- H. Behavioral, psychiatric, and neurologic disorders -- I. Other systemic disorders -- J. Food additives, hazards, and nutrient-drug interactions -- Part V. Nutrition of Populations -- A. Nutrition in a changing world.
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    Research guides and instructional theory -- Learning objectives in research guides -- Learning styles -- Designing and writing for better usability -- Assessment -- Planning, coordinating, and administrating guides.
  • Modern surgical pathology. 2nd ed. v.1-2, 2009
    Part I: The Surgical Pathology Laboratory -- 1. Gross Room and Specimen Handling -- Lucien E. Nochomovitz -- 2. Intraoperative Consultations in Surgical Pathology -- Mahendra Ranchod -- 3. The Surgical Pathology Report -- Debra Hawes, Richard J. Cote, Noel Weidner -- 4. Anatomic Pathology Laboratory Information Systems -- Anil V. Parwani, Eric Schubert, William Gross, John Gilbertson, Michael J. Becich -- 5. Immunohistochemistry -- Debra Hawes, Shan-Rong Shi, David J. Dabbs, Clive R. Taylor, Richard J. Cote -- 6. Role of Electron Microscopy in Modern Diagnostic Surgical Pathology -- Robert A. Erlandson -- 7. Molecular Biology -- Sharon P. Wilczynski -- 8. The Essential Quality Improvement and Educational Programs in Surgical Pathology -- Robert R. Rickert -- 9. Medicolegal Issues in Surgical Pathology -- David B. Troxel -- Part 2: Head and Neck -- 10. Nasal Cavity, Paranasal Sinuses, and Nasopharynx -- Bruce M. Wenig, Mary Richardson -- 11. Larynx -- Lester D.R. Thompson -- 12. Salivary Glands -- Gary L. Ellis, Paul L. Auclair -- 13. Ear and Temporal Bone -- Bruce M. Wenig -- 14. Oral Cavity and Jaws -- Noel Weidner, Kurt Matthews, Joseph A. Regezi -- Part 3: Thoracic System -- 15. Lung -- Saul Suster, Cesar A. Moran -- 16. Serosal Membranes -- Lawrence M. Weiss -- 17. Mediastinum -- Saul Suster, Cesar A. Moran -- 18. Heart and Blood Vessels -- Allen Burke, Renu Virmani -- Part 4: Breast -- 19. Breast -- Noel Weidner -- Part 5: Gastrointestinal Tract -- 20. Esophagus -- Christopher A. Moskaluk -- 21. Stomach -- David Lewin, Klaus J. Lewin (deceased) -- 22. Small Intestine -- David Lewin, Klaus J. Lewin (deceased) -- 23. Large Intestine (Colon) -- Robert E. Petras, Wendy Frankel -- 24. Appendix -- Norman J. Carr, Leslie H. Sobin -- 25. Anus -- David A. Owen -- 26. Pancreas -- Ralph H. Hruban, Noriyoshi Fukushima, Robb E. Wilentz -- 27. Liver -- M. Kay Washington -- 28. Gallbladder and Extrahepatic Bile Ducts -- M. Kay Washington -- Part 6: Urinary Tract and Male Genital System -- 29. Non-Neoplastic Kidney -- Sharda G. Sabnis, Michael N. Koss, W.B. Ross, Zdena Pavlova -- 30. Renal Neoplasia -- John N. Eble, Liang Cheng -- 31. Bladder and Urethra -- Richard J. Cote, Anirban P. Mitra, Mahul B. Amin -- 32. Prostate -- David G. Bostwick, Isabelle Meiers -- 33. Penis and Scrotum -- Pheroze Tamboli, Antonio L. Cubilla, Mahul B. Amin -- 34. Testis and Paratestis Including Spermatic Cord -- Satish K. Tickoo, Pheroze Tamboli, Nancy E. Warner, Mahul B. Amin -- Part 7: Female Reproductive System -- 35. Vulva and Vagina -- Juan C. Felix, R. Tucker Burks, Charles A. Amezcua -- 36. Cervix -- Juan C. Felix, Thomas C. Wright, Jr., Charles A. Amezcua -- 37. Uterus -- Noel Weidner, Michael Peterson -- 38. Fallopian Tubes and Broad Ligament -- Noel Weidner, Michael Peterson -- 39. Ovaries -- Noel Weidner, Michael Peterson -- 40. Gestational Pathology -- Cynthia G. Kaplan -- Part 8: Hematolymphoid System -- 41. Lymph Nodes -- Karen L. Chang, Daniel A. Arber, Lawrence M. Weiss -- 42. Spleen -- Daniel A. Arber -- 43. Bone Marrow -- Daniel A. Arber -- Part 9: Endocrine System -- 44. Thyroid and Parathyroid -- Loretta L.Y. Tse, John K.C. Chan -- 45. Adrenal Gland -- Lawrence M. Weiss, Sean K. Lau -- Part 10: Soft Tissue and Skeletal System -- 46. Soft Tissues -- Lawrence M. Weiss -- 47. Joint and Bone Pathology -- Noel Weidner, Grace Y. Lin, Michael Kyriakos -- Part 11: Skin -- 48. Inflammatory Skin Conditions -- Još Antonio Plaza, Victor G. Prieto -- 49. Tumors of the Skin -- Saul Suster, Tai-Yuen Wong, Martin C. Mihm, Jr. -- Part 12: Nervous System -- 50. Pituitary -- David R. Hinton, Sylvia L. Asa -- 51. Central Nervous System Tumors -- Mahlon D. Johnson, James B. Atkinson -- 52. The Molecular and Genetic Basis of Neurodegenerative Diseases -- Thomas A. Tousseyn, Jeffrey P. Simko, David A. Gaskin, Stephen J. DeArmond -- 53. Muscle and Nerve Biopsy -- James B. Atkinson, Mahlon D. Johnson, Thomas W. Bouldin, William O. Whetsell, Jr. -- 54. Eye and Ocular Adnexa -- Somsiri Sukavatcharin, Narsing A. Rao.
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  • Humans can resist 40 days without eating and 4 days without drinking, but only 4 minutes without breathing: this tells us much about its fundamental importance. Breathed air is slowed down, filtered, warmed and humidified by the nose; many mechanisms are involved in this act, which prevent bronchial tubes and pulmonary alveolus from receiving an excessive and sudden air load. It is well known, on the other hand, that breathing through the mouth causes a lot of problems: inflammatory diseases of the upper airways, sleep apnea syndrome, but also, in some cases, bronchial, pulmonary and even cardiac disorders, that are more easily affecting patients not able to breathe correctly through the nose. For this reason, restoring an efficient nasal function is a very important - and in some cases crucial - issue. This book describes in details an innovative surgical technique called modified inferior turbinoplasty, which offers an excellent solution to the problems associated with the lower turbinate hypertrophy. A turbinate (or nasal concha) is a long, narrow, curled bone shelf that protrudes into the breathing passage of the nose. Most surgical interventions treat only the soft parts of hypertrophic turbinates using laser therapy, radiofrequency treatment, and electrocoagulation, but these procedures often lead to relapse. With this technique, in contrast, all anatomic parts of the turbinate are treated, including bone tissue: the surgeon reduces the inferior nasal concha and the internal nasal tissue, and the mucosa is then remodeled with sutures. The modified inferior turbinoplasty allows the complete avoidance of swabs in the nose, which is fundamental for patients well-being and grant them a quicker recovery. The book will be very useful for othorinolaryngologists, plastic surgeons, endoscopic and maxillofacial surgeons.
  • pt. 1. Understanding food lipid structure and composition -- pt. 2. Modifying lipids for use in food -- pt. 3. Applications of modified lipids in food.
  • Viruses and the innate immune system / Megan L. Shaw, Peter Palese -- How viruses elicit interferon production / David E. Levy, Isabelle J. Marié -- Gene modulated by interferons and double-stranded RNA / Saumendra N. Sarkar, Gregory A. Peters, Ganes C. Sen -- Immunoevasive strategies: host and virus / Markus Wagner, Shahram Misaghi, Hidde L. Ploegh -- Interferon antagonists of influenza viruses / Adolfo Garcia-Sastre -- The anti-interferon mechanisms of paramyxoviruses / Nicola Stock, Stephen Goodbourn, Richard E. Randall -- The strategy of conquest / Sunil J. Advani, Bernard Roizman -- Immunomodulation by poxviruses / James B. Johnston, Grant McFadden -- Interferon antagonists encoded by emerging RNA viruses / Christopher F. Basler -- Viral pathogenesis and toll-like receptors / Susan R. Ross -- Digesting oneself and digesting microbes / Montrell Seay, Savithramma Dinesh-Kumar, Beth Levine -- Genetic variation in host defenses and viral infections / Eunhwa Choi, Stephen J. Chanock.
  • "This book brings together leading international experts to discuss recent advances in the regulation of presynaptic voltage-gated Ca2+ channels (VGCCs), key signal transducers that represent one of the most widely modulated proteins in the body. It is now commonly accepted that presence of the VGCC complex defines an excitable cell. At a basic level, VGCCs transduce membrane potential change to chemical neurotransmitter release at presynaptic terminals. However, on-going scientific research, presented here, in areas including neuroscience, electrophysiology, pharmacology, biochemistry and, increasingly, proteomics, has revealed the widespread nature of modulation of the presynaptic VGCC complex. This book reviews and discusses the following topics: The fundamental role of the VGCC pore-forming CaVa subunit, and some of their binding partners, in presynaptic function and synaptic plasticity. Modulation of presynaptic CaVa subunits by auxiliary CaVb and a2d subunits and by their major interaction partners, such as active zone scaffolding proteins, synaptic proteins, G proteins and small GTPases, which, together, contribute to the VGCC proteome. Work at the cutting edge of research, including how direct electrophysiology recordings from presynaptic terminals and introduction of synthetic CaVa peptides into presynaptic terminals has expanded our knowledge of VGCC function. Evidence emerging over the last decade demonstrating that VGCC subunits represent bona fide molecular targets for therapeutic drug discovery. This development is illustrated by the introduction of the CaV2.2 blocker ziconotide, which represents an important proof-of-concept, but is best exemplified by the emergence of gabapentinoids, which bind the VGCC auxiliary a2d subunit, as first-line treatments for chronic neuropathic pain. Throughout, chapters are accompanied with illustrative Tables and Figure providing a useful and comprehensive summary of the current state-of-play in this area of significant therapeutic interest. Work described here also provides a solid basis for future research in this important area." -- Back cover.
  • The diagnosis and management of infectious diseases -- Nose and throat syndromes -- Infectious mononucleosis and mononucleosis-like syndromes -- Mouth and salivary gland syndromes -- Eye, ear, and sinus syndromes -- Face and neck syndromes -- Middle respiratory syndromes -- Pneumonia syndromes -- Neurologic syndromes -- Fever and shock syndromes -- Rash syndromes -- Gastrointestinal syndromes -- Hepatitis syndromes -- Urinary syndromes -- Genital syndromes -- Orthopedic syndromes -- Skin syndromes -- Cardiovascular syndromes -- Perinatal syndromes -- HIV infection and AIDS -- Exposure problems -- Infections complicating chronic diseases -- The child with frequent, severe, or unusual infections: congenital immunodeficiency syndromes.
  • An Introduction to Mohs Micrographic Surgery -- Indications for Mohs Micrographic Surgery -- Preoperative Evaluation -- Mohs Micrographic Surgery Operative Room Setup -- Anesthetic Considerations: Local Versus Regional -- Cutaneous Anatomy in Mohs Micrographic Surgery -- Mohs Surgery: Fixed Tissue Technique -- Fresh Tissue Technique -- Special Considerations for Mohs Micrographic Surgery in Organ Transplant Recipients -- Mohs Micrographic Surgery in Ethnic Skin -- Histopathology Laboratory Setup and Necessary Instrumentation -- Tissue Transport and Initial Processing Cryostat Preparation of Slides -- Histopathologic Interpretation of Mohs Slides -- Tissue Specimen Documentation, Record Keeping, and Sample Storage -- Immunostains -- Basal Cell Carcinoma -- Squamous Cell Carcinoma -- Mohs Micrographic Surgery for the Treatment of Cutaneous Melanoma -- Dermatofibrosarcoma Protuberans -- Microcystic Adnexal Carcinoma -- Atypical Fibroxanthoma -- Extramammary Paget Disease -- Leiomyosarcoma -- Merkel Cell Carcinoma -- Selected Sweat Gland Carcinomas -- Sebaceous Carcinoma -- Mohs Micrographic Surgery for the Eyelid -- Mohs Surgery for Periungual and Subungual Skin Cancer -- Genitalia -- Deep Structures of the Head and Neck -- Complications of Mohs Micrographic Surgery -- Eyelid Reconstruction After Mohs Micrographic Surgery -- Flaps -- Skin Grafting -- Side to Side Closure After Mohs Surgery -- Prosthetic Rehabilitation -- Combination Therapy for the Nonsurgical Treatment of Skin Cancers: Latest Research at Mount Sinai -- Training and Regulation in Mohs Surgery -- Establishing a Mohs Practice -- International Perspective of Mohs Micrographic Surgery: South America -- International Perspective of Mohs Micrographic Surgery: Europe -- International Perspective of Mohs Micrographic Surgery: East Asia -- International Perspective of Mohs Micrographic Surgery: Australia and New Zealand -- Information for Patients and Safety Considerations -- Ethical Issues Related to Mohs Skin Cancer Surgery -- Medicolegal Issues Regarding Mohs Micrographic Surgery -- Psychological Issues Regarding Mohs Micrographic Surgery.
  • Gene regulatory networks orchestrating B cell fate specification, commitment, and differentiation / K.L. Medina, H. Singh -- Helix-loop-helix proteins in lymphocyte lineage determination / B.L. Kee -- Ikaros-family proteins : in search of molecular functions during lymphocyte development / B.S. Cobb, S.T. Smale -- Biochemistry of V(D)J recombination / D.G. Schatz, E. Spanopoulou -- The pre-B cell receptor in B cell development : recent advances, persistent questions and conserved mechanisms / M.R. Clark ... [et al.] -- Transcriptional control of B cell activation / L.M. Corcoran -- Expression of MHC II genes / G. Drozina ... [et al.] -- Class switch recombination : an emerging mechanism / A.L. Kenter -- Blimp-1 ; Immunoglobulin secretion and the switch to plasma cells / R. Schiammas, M.M. Davis -- Wnt signaling in lymphopoiesis / A. Timm, R. Grosschedl.
  • "This brand new book discusses the most relevant technique or combination thereof for each disease and provides guidance on which modality to use -It is a disease oriented reference meant for interpreting integrated imaging studies. While it focuses on PET-CT and SPECT-CT, it also integrates PET-MR were applicable. Features: Allows clinical hybrid imaging users to compare modalities and decide whether to use PET/CT, PET/MR or SPECT/CT to solve a clinical question. Focus on clinical applications sans technological & radiopharmaceutical details. Inclusion of emerging field of PET/MR. New PART III on workflow and normal scans with various clinical tracers. Only book that incorporates PET/MR in a systematic way"--Provided by publisher.
  • I. Molecular Aspects of Iron Transport -- 1. Iron Chemistry / Wesley R. Harris -- 2. Transferrins / Ross T. A. MacGillivray and Anne B. Mason -- 3. The Transferrin Receptor / Caroline A. Enns -- 4. Molecular Aspects of Release of Iron from Transferrin / Qing-Yu He and Anne B. Mason -- 5. Ferritins: Structural and Functional Aspects / Paolo Arosio and Sonia Levi -- 6. The Divalent Metal-Ion Transporter (DCT1/DMT1/Nramp2) / Hiromi Gunshin and Matthias A. Hediger -- 7. Basolateral Transport of Iron in Mammalian Intestine: From Physiology to Molecules / Andrew T McKie and Robert J. Simpson -- 8. HFE / Robert E. Fleming, Robert S. Britton, Abdul Waheed, William S. Sly, and Bruce R. Bacon -- 9. Regulation of Iron Homeostasis by Iron Regulatory Proteins 1 and 2 / Eric S. Hanson and Elizabeth A. Leibold -- 10. Iron-Response Element (IRE) Structure and Combinatorial RNA Regulation / Hans E. Johansson and Elizabeth C. Theil -- 11. Frataxin and Mitochondrial Iron / Pierre Rustin -- 12. Siderophore Chemistry / Alain Stintzi and Kenneth N. Raymond -- 13. Iron Chelator Chemistry / Zu D. Liu and Robert C. Hider -- II. Cellular Iron Transport -- 14. Iron Acquisition in Plants / Elizabeth E. Rogers and Mary Lou Guerinot -- 15. Iron Uptake in Yeast / Orly Ardon, Jerry Kaplan, and Brooke D. Martin -- 16. Bacterial Iron Transport / Volkmar Braun and Klaus Hantke -- 17. Uptake of Transferrin-Bound Iron by Mammalian Cells / Deborah Trinder and Evan Morgan -- 18. Transport of Non-Transferrin-Bound Iron by Hepatocytes / Joel G. Parkes and Douglas M. Templeton -- 19. Iron Acquisition by the Reticuloendothelial System / Günter Weiss -- 20. Iron Transport in the Central Nervous System / Joseph R. Burdo and James R. Connor -- 21. Iron Uptake by Neoplastic Cells / Des R. Richardson -- 22. Novel Methods for Assessing Transport of Iron Across Biological Membranes / Z. Ioav Cabantchik, Silvina Epsztejn, and William Breuer -- III. Physiology of Iron Transport -- 23. Regulation of Intestinal Iron Transport / Gregory J. Anderson and Christopher D. Vulpe -- 24. Regulation of Systemic Iron Transport and Storage / Pierre Brissot, Christelle Pigeon, and Olivier Loréal -- 25. Regulation of Liver Iron Metabolism / Gaetano Cairo -- 26. Iron Utilization in Erythrocyte Formation and Hemoglobin Synthesis / Prem Ponka --IV. Disorders of Iron Transport -- 27. Animal Models of Iron Transport and Storage Disorders / Nancy C. Andrews -- 28. Hemochromatosis: Diagnosis and Management Following the Discovery of the Gene / Paul C. Adams -- 29. Transfusional Iron Overload / Nancy F Olivieri -- 30. Aceruloplasminemia / Nathan E. Hellman and Z. Leah Harris -- 31. Hereditary Hyperferritinemia Cataract Syndrome / Carole Beaumont and Domenico Girelli -- 32. Other Disorders of Increased Iron Absorption: Iron Overload in Africans and African Americans / Fitzroy W. Dawkins and Victor R. Gordeuk -- 33. Iron Chelation / Chaim Hershko, Gabriela Link, and Avraham M. Konijn.
  • This book focuses on the function of antibodies in vivo. Recent years have seen an exponential growth in knowledge about the molecular and cellular mechanisms of antibody activity. These new results dramatically changed our view of how antibodies function in vivo. The importance of this class of molecules is demonstrated by the heightened susceptibility to infections of humans and mice with an altered capacity to generate pathogen specific antibody responses. Thus, the majority of our currently available vaccines, such as vaccines against influenza, measles and hepatitis focus on the generation of long lasting antibody responses. Recent evidence from a variety of in vivo model systems and from human patient cohorts has highlighted the exclusive role of cellular Fc-receptors for certain immunoglobulin isotypes and subclasses. With the recent discovery of a human Fc-receptor for IgM all different human immunoglobulin isotypes now have a cellular receptor, providing a feedback mechanism and link between antibodies and the cellular components of the immune system. Moreover it has become clear the complement and Fc-receptor system are tightly connected and regulate each other to ensure a well balanced immune response. Among the immunoglobulin isotypes IgG plays a very important protective role against microbial infections and also as a therapeutic agent to kill tumor cells or autoantibody producing B cells in autoimmune disease. Transfer of our knowledge about the crucial function of Fc-receptors has led to the production of a second generation of therapeutic antibodies with enhanced binding to this class of receptors. Binding of antibodies to Fc-receptors leads to the recruitment of the potent pro-inflammatory effector functions of cells from the innate immune system. Hence, Fc-receptors link the innate and adaptive immune system, emphasizing the importance of both arms of the immune system and their crosstalk during anti-microbial immune responses. Besides this pro-inflammatory activity immunoglobulin G (IgG) molecules are long known to also have an anti-inflammatory function. This is demonstrated by the use of high dose intravenous immunoglobulins as a therapeutic agent in many human autoimmune diseases. During the past five years several new insights into the molecular and cellular pathways of this anti-inflammatory activity were gained radically changing our view of IgG function in vivo. Several lines of evidence suggest that the sugar moiety attached to the IgG molecule is responsible for these opposing activities and may be seen as a molecular switch enabling the immune system to change IgG function from a pro- to an anti-inflammatory activity. There is convincing evidence in mice and humans that aberrant IgG glycosylation could be an important new pathway for understanding the impaired antibody activity during autoimmune disease. Besides this tremendous increase in basic knowledge about factors influencing immunoglobulin activity the book will also provide insights into how these new insights might help to generate novel therapeutic approaches to enhance IgG activity for tumor therapy on the one hand, and how to block the self-destructive activity of IgG autoantibodies during autoimmune disease on the other hand.
  • Methods for labeling non-phagocytic cells with MR contrast agents / Joseph A. Frank, Stasia A. Anderson, & Ali S. Arbab -- Cellular imaging of cell transplants / Michel Modo & Jeff W.M. Bulte -- Cellular and molecular imaging of the diabetic pancreas / Zdravka Medarova & Anna Moore -- Functional cellular imaging with manganese / Vincent van Meir & Annemie van der Linden -- Translating promising experimental approaches to clinical trials / Adrian D. Nunn -- An outlook on cellular and molecular MR imaging / Michel Modo & Jeff W.M. Bulte. What is molecular and cellular imaging? / Michel Modo & Jeff W.M. Bulte -- The physicochemical principles of MR contrast agents / Peter Caravan -- Paramagnetic contract agents / Silvio Aime ... [et al.] -- Superparamagnetic contrast agents / Claire Corot ... [et al.] -- Physical mechanism and applications of cest contrast agents / Mike McMahon ... [et al.] -- Paracest contrast agents / A. Dean Sherry & Mark Woods -- Genetic approaches for modulating MRI contrast / Eric Ahrens, Williams F. Goins, Clinton S. Robinson -- Molecular and functional mr imaging of cancer / Michael A. Jacobs ... [et al.] -- Molecular imaging of atherosclerosis with magnetic resonance / Karen C. Briley-Saebo ... [et al.] -- Molecular imaging of apoptosis / Mikko Kettunen & Kevin M. Brindle -- Molecular imaging of reporter genes / Keren Ziv ... [et al.] -- Pharmacological MRI as a molecular imaging technique / Y. Iris Chen & Bruce Jenkins -- Cellular imaging of the liver using contrast agents / N. Cem Balci & Sukru Mehmet Erturk -- Cellular imaging of macrophage activity in infection and inflammation / Martin Rausch ... [et al.] -- Cellular imaging of macrophage activity in stroke / Ralph Weber & Mathias Hoehn -- Magnetic resonance imaging in developmental biology / Cyrus Papan, J. Michael Tyszka, Russell E. Jacobs --
  • Preface -- Mouse mutagenesis and disease models for Neuropsychiatric disorders. -- Drosophila as a model organism for the study of neuropsychiatric disorders -- Transgenic animal models of Huntington{u2019}s Disease -- Molecular genetic models related to schizophrenia and psychotic illness: heuristics and challenges -- Animal Models of Depression: Molecular Perspectives.-Animal models of ADHD -- Mouse Models of Autism: Testing Hypotheses about Molecular Mechanisms -- Advances in animal models of drug addiction -- When the serotonin transporter gene meets adversity: The contribution of animal models to understanding epigenetic mechanisms in affective disorders and resilience -- Functional and Pharmacological MRI in understanding brain function at a systems level -- The pig as model animal for studying cognition and neurobehavioral disorders.
  • This book provides the most up-to-date coverage of the combined use of imaging modalities in order to acquire important functional and morphological information on cardiovascular disease and enhance disease detection. The recent developments in PET/MRI, cardiac CT, PET/CT, and SPECT/CT and their impact on clinical practice are explained, and special attention is also devoted to imaging parameters and protocols for use in practice and research. The utility of multimodality imaging techniques for diagnosis and evaluation is discussed in the context of various clinical scenarios, including ischemic cardiomyopathy, myocarditis, myocardial fibrosis, cardiac sarcoidosis, and atherosclerotic plaque disease. Written by renowned researchers and clinicians, the book is an ideal concise reference on today's most advanced imaging techniques. It will appeal to all clinicians, trainees, and technicians who are involved in the diagnosis and risk assessment of cardiovascular disease.
  • Molecular approaches to controlling cancer 2005
    Cold Spring Harb Lab Press
    Cancer genetics and genomes -- DNA damage response -- Cancer biology and stem cells -- Telomeres, senescence, and aging -- Animal models for cancer -- Gene expression and cancer -- Tumor responses to microenvironment -- Angiogenesis -- Discovering cancer targets -- Therapeutic approaches.
  • Currently, there are tremendous advances being made in understanding the basic science of both the structure and function of botulinum neurotoxins. This knowledge is opening up opportunities in regard to both therapeutic uses and treatment and protection options for civil and bio-defense applications. This volume fully evaluates the status of neurotoxin research and exploitation. The book is a multi-authored collection of chapters written by the leading authorities responsible for the current scientific and clinical research that is advancing the understanding and exploitation of the neurotoxins, and is both up to date and authoritative.
  • Part 1. Molecular Biology of Selected Hemato-oncologic Diseases -- Molecular Biology of Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Monika D. Kraszewska, Katarzyna Derwich and Tomasz Szczepański -- Genetic Mechanisms and Molecular Markers of Neoplastic Transformation in Acute Myeloid Leukemia / Agata A. Filip, Marta Libura, Sebastian Giebel and Olga Haus -- Molecular Pathogenesis of Aggressive B-cell Lymphomas / Przemysław Juszczyński and Krzysztof Warzocha -- Molecular Biology and Classification of Multiple Myeloma / Anna Dmoszyńska and Norbert Grząśko -- Chronic Lymphocytic Leukemia / Anton W. Langerak and Yorick Sandberg -- Molecular Biology of Chronic Myeloid Leukemia / Tomasz Sacha, Kajetana Foryciarz and Aleksander B. Skotnicki -- Molecular Biology of Myelodysplastic Syndromes / Francesc Solé -- Myeloproliferative Neoplasms / Andrzej Hellmann, Maria Bieniaszewska, Witold Prejzner and Aleksandra Leszczyńska -- Part 2. Diagnostics and Monitoring of Therapy of Hemato-oncologic Deseases -- Flow Cytometric Immunophenotyping as Diagnostic Tool of Hematopoietic Malignancies / Łukasz Sędek, Juan Flores-Montero, Joanna Bulsa, Susana Barrena and Julia Almeida, et al. -- Cytogenetics in Hematology / Olga Haus, Anna Poluha and Katarzyna Skonieczka -- Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Tomasz Szczepański, Małgorzata Dawidowska and Katarzyna Derwich -- Gene Expression Profiling in Hematologic Malignancies / Przemysław Juszczyński, Bjoern Chapuy, Małgorzata Szczepaniak and Krzysztof Warzocha -- Part 3. Molecular Procedures Involved in Hematopoietic Stem Cell Transplantation -- Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Wachowiak -- Genetic Basis of Donor-Recipient Matching in Allogeneic Transplantation of Hematopoietic Stem Cells / Jacek Nowak and Jacek Wachowiak -- Chimerism Following Allogeneic Transplantation of Hematopoietic Stem Cells / Małgorzata Dawidowska, Katarzyna Guz, Ewa Brojer, Jacek Wachowiak and Michał Witt -- Peritransplantation Monitoring of Minimal Residual Disease in Acute Lymphoblastic Leukemia / Małgorzata Dawidowska, Katarzyna Derwich and Tomasz Szczepański -- Biobanks of Cellular Material / Wiesław Wiktor-Jędrzejczak and Elżbieta Urbanowska -- Part 4. Molecular Diagnostic Protocols -- Biobanking of Cellular Material / Anna Poluha and Elżbieta Urbanowska -- Isolation of Mononuclear Cells from Human Blood and Bone Marrow by Density Gradient Centrifugation / Małgorzata Dawidowska -- Molecular Techniques Commonly Used in Hemato-oncology / Monika D. Kraszewska and Ewa Ziętkiewicz -- Genetic Methods of HLA Typing / Jacek Nowak, Renata Mika-Witkowska and Elżbieta Graczyk-Pol -- Post-Transplant Chimerism Analysis Through STR-PCR and RQ-PCR / Małgorzata Dawidowska, Katarzyna Guz, Agnieszka Orzińska, Justyna Smolarczyk-Wodzyńska and Monika D. Kraszewska, et al. -- Analysis of Minimal Residual Disease with the Use of Rearrangements of Ig/TCR Genes Through RQ-PCR / Małgorzata Dawidowska, Vincent H. J. van der Velden, Michał Witt and Tomasz Szczepański -- Molecular Diagnostics of Acute Myeloblastic Leukemia / Marta Libura, Agata A. Filip and Olga Haus -- Assessment of the Presence and the Level of BCR-ABL Fusion Gene Expression and Mutational Status in ABL Kinase Domain / Sylwia Czekalska, Magdalena Zawada and Izabela Florek -- Studies of Rearrangements and Somatic Hypermutation of IGHV Genes in Chronic Lymphocytic Leukemia / Anton W. Langerak, Richard Rosenquist, Paolo Ghia, Chrysoula Belessi and Kostas Stamatopoulos, et al. -- Molecular Biology Methods in the Diagnosis of Multiple Myeloma / Anna Dmoszyńska and Sylwia Chocholska -- Molecular Methods in Myeloproliferative Neoplasms / Aleksandra Leszczyńska, Witold Prejzner, Maria Bieniaszewska and Andrzej Hellmann -- Informed Consent for Participation in Research Project / Małgorzata Dawidowska and Michał Witt.
  • Protein misassembly: macromolecular crowding and molecular chaperones / R. John Ellis -- The cellular "networking" of mammalian HSP27 and its functions in the control of protein folding, redox state and apoptosis / André-Patrick Arrigo -- Molecular interaction network of the HSP90 chaperone system / Rongmin Zhao and Walid A. Houry -- Organization of the functions and components of the endoplasmic reticulum / Yuichiro Shimizu and Linda M. Hendershot -- Molecular crime and cellular punishment: active detoxification of misfolded and aggregated proteins in the cell by the chaperone and protease networks / Marie-Pierre Hinault and Pierre Goloubinoff -- Chaperones as parts of cellular networks / Peter Csermely, Csaba Söti and Gregory L. Blatch -- Chaperones as parts of organelle networks / György Szabadkai and Rosario Rizzuto -- Heat shock factor 1 as a coordinator of stress and developmental pathways / Julius Anckar and Lea Sistonen -- Chaperone regulation of the heat shock protein response / Richard Voellmy and Frank Boellmann -- Mechanisms of activation and regulation of the heat shock-sensitive signaling pathways / Sébastien Ian Nadeau and Jacques Landry -- Membrane-regulated stress response: a theoretical and practical approach / László Vígh ... [et al.] -- Beyond the lipid hypothesis: mechanisms underlying phenotypic plasticity in inducible cold tolerance / Scott A.L. Hayward ... [et al.] -- Trehalose as a "chemical chaperone:" fact and fantasy / John H. Crowe -- Chaperones as part of immune networks / Zoltán Prohászka -- The stress of misfolded proteins: C. elegans models for neurodegenerative disease and aging / Heather R. Brignull, James F. Morley and Richard I. Morimoto -- HSP90 and developmental networks / Suzannah Rutherford, Jennifer R. Knapp and Peter Csermely.
  • Cancer incidences increase in people living with HIV/AIDS. Over 2 million people currently live with HIV/AIDS in the US. This number will increase as HAART prolongs the average lifespan and as (at least in some states) the number of new HIV infections increase again. As this population ages their incidence rates for cancer will increase, as well. Recently, new rational targets for cancer therapy have emerged. But their application to the care of HIV+ patients is slow, because of concerns about the weakened immune status of the patients, because of possible drug interactions with HAART and because some of the AIDS defining cancer are rare.
  • Print Material
  • Cancer : a genetic disorder / William C. Hahn, Robert A. Weinberg -- Oncogenes and signal transduction / Luca Grumolato, Stuart A. Aaronson -- Tumor suppressor genes / Nelson E. Brown, Philip W. Hinds -- DNA repair pathways and human cancer / Alan D. D'Andrea -- Epigenetics and cancer / Stephen B. Baylin -- Infectious agents and cancer / Peter M. Howley -- Environmental carcinogenesis / Erika L. Abel, John DiGiovanni -- Animal models : flies, fish, and yeast / Elspeth Payne, A. Thomas Look -- Genetic mouse models of cancer / Monte M. Winslow, Tyler Jacks -- Cancer stem cells and the microenvironment / Hasan Korkaya, April Davis, Max S. Wicha -- Regulation of the cell cycle / Yan Li, Olena Barbash, J. Alan Diehl -- Cell growth / David A. Guertin, David M. Sabatini -- Metabolism of cell growth and proliferation / Lydia W.S. Finley, Craig B. Thompson -- Apoptosis, necrosis, and autophagy / Eileen White, Douglas R. Green, Anthony G. Letai -- Cellular senescence / Jessica E. Bolden, Scott W. Lowe -- Role of the microenvironment in tumor initiation, progression, and metastasis / Cyrus M. Ghajar, Ana Luísa Correia, Mina J. Bissell -- Tumor angiogenesis / Brian Keith, M. Celeste Simon -- Invasion and metastasis / Swarnali Acharyya, Lynn Matrisian, Danny R. Welch, Joan Massagué -- Inflammation and cancer / Daniela F. Quail, Johanna A. Joyce -- Cancer systems biology : the future / Andrea Califano -- Biomarkers for assessing risk of cancer / Xifeng Wu, Jian Gu -- Protein biomarkers for detecting cancer : molecular screening / Susan Fisher, H. Ewa Witkowska -- Technology of analyzing nucleic acids in Cancer / Elaine R. Mardis -- Understanding and using information about cancer genomes / Paul T. Spellman, Josh Stuart, Joe W. Gray -- High-content analysis with cellular and tissue systems biology : a bridge between cancer cell biology and tissue-based diagnostics / Albert Gough, Timothy Lezon, James R. Faeder, Chakra Chennubhotla, Robert F. Murphy, Rebecca Critchley-Thorne, D. Lansing Taylor -- Molecular genetics of acute lymphoblastic leukemia / Eric S. Schafer, Judith Margolin, David G. Poplack, Karen R. Rabin -- Molecular biology of childhood neoplasms / David Malkin -- Biology of adult myelocytic leukemia and myelodysplasia / Sean M. Post, Hagop Kantarjian, Alfonso Quintás-Cardama -- Lymphoma / Owen A. O'Connor, Jennifer Amengual, Changchun Deng, Ahmed Sawas, Bachir Alobeid, Daniela Hoehn, Govind Bhagat -- Multiple myeloma / Giovanni Tonon, Kenneth C. Anderson -- Molecular mechanisms of esophageal cancer / Mario D. Terán, Ronan Kelly, Malcolm V. Brock -- Molecular basis of lung cancer / Jill E. Larsen, Ramaswamy Govindan, John D. Minna -- Molecular pathogenesis of head and neck cancer / Matthew L. Hedberg, Jennifer R. Grandis -- Colon and rectal cancer / Eric R. Fearon -- Molecular pathogenesis of pancreatic adenocarcinoma / Rachna T. Shroff, James L. Abbruzzese -- Molecular biology of breast cancer / Adrian V. Lee, Steffi Oesterreich, Nancy E. Davidson -- Molecular pathogenesis of ovarian cancer / Robert C. Bast Jr., Ignacio Romero, Gordon B. Mills -- Molecular basis of prostate cancer / Long-Cheng Li, Andrew C. Hsieh, Davide Ruggero, Kirsten L. Greene, Peter R. Carroll -- Molecular abnormalities in kidney cancer / Sabina Signoretti, Toni K. Choueiri, William G. Kaelin Jr. -- Biology of primary brain tumors / Matthew C. Havrda, Mark A. Israel -- Epithelial skin cancer / Adam B. Glick, Stuart H. Yuspa -- Molecular basis for treating cutaneous molecular / Marc S. Ernstoff -- Thyroid cancer / Steven I. Sherman -- Soft tissue sarcomas / Julie D.R. Reimann, Christopher D.M. Fletcher -- From bench to bedside with targeted therapies / John Mendelsohn -- Cancer therapeutics / William N. Hait, Eric Rubin, Joseph R. Bertino -- Natural and acquired resistance to cancer therapies / Branimir I. Sikic -- Phase I trials today / Daniel Morgensztern, Patricia M. LoRusso, Scott A. Boerner, Roy S. Herbst, Joseph Paul Eder -- Pharmacogenomics / Peter H. O'Donnell, Mark J. Ratain -- Monoclonal antibodies for the treatment of cancer / Louis M. Weiner, Rishi Surana -- Cancer and the cellular immune response / Patrick Hwu, Gregory Lizée, Yong-Jun Liu -- Cancer immunotherapy with vaccines and checkpoint blockade / Drew Pardoll -- Interferons / Ernest C. Borden -- Gene therapy and oncolytic viruses / Tanja Meyer Tamguney, W. Michael Korn, Frank McCormick -- RNA as a therapeutic molecule / George Adrian Calin, Carlo Maria Croce -- Heat shock protein 90 and the proteasome : housekeeping proteins that are also molecular targets for cancer therapy / Len Neckers, Mehdi Mollapour -- Hematopoietic growth factors and cytokines / Suhendan Ekmekcioglu, Razelle Kurzrock, Elizabeth A. Grimm -- Cancer chemoprevention / Scott M. Lippman, J. Jack Lee -- Molecular pathology / Christopher L. Corless.
  • The book describes how the balance between pro- and anti-inflammatory molecules is related to health and disease. It is suggested that many diseases are initiated and their progress is influenced by inflammatory molecules and a decrease in the production and/or action of anti-inflammatory molecules and this imbalance between pro- and anti-inflammatory molecules seems to have been initiated in the perinatal period. This implies that strategies to prevent and manage various adult diseases should start in the perinatal period. An alteration in the metaolism of essential fatty acids and their anti-inflammatory molecules such as lipoxins, resolvins, protecitns, maresins and nitrolipids seems to play a major role in the pathobiology of several adult diseases. Based on these concepts, novel therapeutic approaches in the management of insulin resistance, obesity, type 2 diabetes mellitus, metabolic syndrome, cancer, lupus, rheumatoid arthritis and other auto-immune diseases are presented. Based on all these evidences, a unified concept that several adult diseases are due to an alteration in the balance between pro- and anti-inflammatory molecules is discussed and novel methods of their management are presented.
  • Clinical approach to rare lung diseases -- Clinical trials for rare lung diseases -- Idiopathic and familial pulmonary arterial hypertension -- Lymphangioleiomyomatosis -- Autoimmune pulmonary alveolar proteinosis -- Mutations in surfactant protein C and interstitial lung disease -- Hereditary haemorrhagic telangiectasia -- Hermansky-Pudlak Syndrome -- Alpha-1 antitrypsin deficiency -- Marfan syndrome -- Surfactant deficiency disorders: SP-B and ABCA3 -- Pulmonary capillary hemangiomatosis -- Anti-glomerular basement disease: Goodpasture's Syndrome -- Primary ciliary dyskinesia -- Pulmonary alveolar microlithiasis -- Cystic fibrosis -- Pulmonary Langerhans' cell histiocytosis: advances in the understanding of a true dendritic cell lung disease -- Sarcoidosis -- Scleroderma lung disease.
  • Syntrophic associations in methanogenic degradation / B. Schink -- Symbiosis between non-related bacteria in phototropic consortia / J. Overmann -- Prokaryotic symbionts of termite gut flagellates : phylogenetic and metabolic implications of a tripartite symbiosis / A. Brune, U. Stingl -- Towards an understanding of the killer trait : Caedibacter endocytobionts in Paramecium / J. Kusch, H.-D. Görtz -- Bacterial ectosymbionts which confer motility : Mixotricha paradoxa from the intestine of the Australian termite Mastotermes darwiniensis / Helmut König ... [et al.] -- Extrusive bacterial ectosymbionts of ciliates / G. Rosati -- Hydrogenosomes and symbiosis / J.H.P. Hackstein, N. Yarlett -- Molecular interactions between Rhizobium and legumes / P. Skorpil, W.J. Broughton -- Molecular mechanisms in the nitrogen-fixing Nostoc-bryophyte symbiosis / J.C. Meeks -- Symbiosis of thioautotrophic bacteria with Riftia pachyptila / F.J. Stewart, C.M. Cavanaugh -- Symbioses of methanotrophs and deep-sea mussels (Mytilidae: Bathymodiolinae) / E.G. DeChaine, C.M. Cavanaugh -- Symbioses between bacteria and gutless marine oligocahetes / N. Dubilier, A. Blazejak, C. Rühland -- Roles of bacterial regulators in the symbiosis between Vibrio fischeri and Euprymna scalopes / K. Geszvain, K. Visick -- Molecular requirements for the colonization of Hirudo medicinalis by Aeromonas veronii / J. Graf.
  • Basic principles of fluorescence and energy transfer / Larry E. Morrison -- Multiplex detection of mutations / David S. Perlin, Sergey Balashov, and Steven Park -- Detection of salmonella species in foodstuffs / Arvind A. Bhagwat ... [et al.] -- Identification of homozygous transgenic mice by genomic real-time PCR / Gunter Schmidtke and Marcus Groettrup -- Quantitative analysis of gene expression relative to 18S rRNA in carcinoma samples using the LightCycler instrument and a SYBR greenI-based assay : determining FAT10 mRNA levels in hepatocellular carcinoma / Sebastian Lukasiak ... [et al.] -- Absolute quantitation of feline leukemia virus proviral DNA and viral RNA loads by TaqMan real-time PCR and RT-PCR / Valentino Cattori and Regina Hofmann-Lehmann -- High-throughput real-time PCR / Thomas D. Schmittgen, Eun Joo Lee, and Jinmai Jiang -- Design and use of scorpions fluorescent signalling molecules / Rachael Carters ... [et al.] -- Hybridization probe pairs and single-labeled probes : an alternative approach for genotyping and quantification / Thomas Froehlich and Oliver Geulen -- EasyBeacons for the detection of methylation status of single CpG duplets / Ulf B. Christensen -- Quenched autoligation probes / Adam P. Silverman, Hiroshi Abe, and Eric T. Kool -- HyBeacon probes for rapid DNA sequence detection and allele discrimination / David J. French ... [et al.] -- FIT-probes in real-time PCR / Elke Socher and Oliver Seitz -- SNP genotyping by unlabeled probe melting analysis / Maria Erali, Robert Palais, and Carl Wittwer -- Molecular beacons for protein-DNA interaction studies / Jun Li ... [et al.] -- DNA polymerase profiling / D. Summerer -- Modular reporter hairpin ribozymes for analyzing molecular interactions / S. Hani Najafi-Shoushtari and Michael Famulok -- Screening of molecular interactions using reporter hammerhead ribozymes / Jörg S. Hartig and Michael Famulok.
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    v. 1. Nature and metabolism of extracellular proteins.
  • Chromatin regulation by long non-coding RNAs / Daniel C. Factor, Paul J. Tesar and Ahmad M. Khalil -- Regulatikon of eukaryotic cell differentiation by long non-coding RNAs / Juan R. Alvarez-Dominguez, Wenqian Hu and Harvey F. Lodish -- Roles of long non-coding RNAs in X-chromsome inactivation / J. Mauro Calabrese and Terry Magnuson -- Roles of long non-coding RNAs in genomic imprinting / Kristen Martins-Taylor and Stormy J. Chamberlain -- Dysregulation of long non-coding RNAs in human disease / Nianwei Lin and Tariq M. Rana -- Functions of long non-coding RNAs in non-mamallian systems / Alex Tuck and David Tollervey -- Emerging technologies to study long non-coding RNAs / Fereshteh Jahaniani ... [et al.]
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  • Molecular biology of the cell. 4th ed. 2002
    NCBI Bookshelf, Fulltext accessible by its search box
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    Cells and genomes -- Cell chemistry and biosynthesis -- Proteins -- DNA, chromosomes, and genomes -- DNA replication, repair, and recombination -- How cells read the genome: from DNA to protein -- Control of gene expression -- Manipulating proteins, DNA, and RNA -- Visualizing cells -- Membrane structure -- Membrane transport of small molecules and the electrical properties of membranes -- Intracellular compartments and protein sorting -- Intracellular vesicular traffic -- Energy conversion: mitochondria and chloroplasts -- Mechanisms of cell communication -- The cytoskeleton -- The cell cycle -- Apoptosis -- Cell junctions, cell adhesion, and the extracellular matrix -- Cancer -- Sexual reproduction: meiosis, germ cells, and fertilization -- Development of multicellular organisms -- Specialized tissues, stem cells, and tissue renewal -- Pathogens, infection, and innate immunity -- The adaptive immune system. Tables: The genetic code, amino acids.
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    "As the amount of information in biology expands dramatically, it becomes increasingly important for textbooks to distill the vast amount of scientific knowledge into concise principles and enduring concepts. As with previous editions, Molecular Biology of the Cell, Sixth Edition accomplishes this goal with clear writing and beautiful illustrations. The Sixth Edition has been extensively revised and updated with the latest research in the field of cell biology, and it provides an exceptional framework for teaching and learning. The entire illustration program has been greatly enhanced. Protein structures better illustrate structure-function relationships, icons are simpler and more consistent within and between chapters, and micrographs have been refreshed and updated with newer, clearer, or better images. As a new feature, each chapter now contains intriguing open-ended questions highlighting "What We Don't Know," introducing students to challenging areas of future research. Updated end-of-chapter problems reflect new research discussed in the text. Thought-provoking end-of-chapter questions have been expanded to all chapters, including questions on developmental biology, tissues and stem cells, the immune system, and pathogens."-- Provided by publisher.
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    The Mendelian view of the world -- Nucleic acids convey genetic information -- The importance of weak chemical interactions -- The importance of high-energy bonds -- Weak and strong bonds determine macromolecular structure -- The structures of DNA and RNA -- Genome structure, chromatin, and the nucleosome -- The replication of DNA -- The mutability and repair of DNA -- Homologous recombination at the molecular level -- Site-specific recombination and transposition of DNA -- Mechanisms of transcription -- RNA splicing -- Translation -- The genetic code -- Transcriptional regulation in prokaryotes -- Transcriptional regulation in eukaryotes -- Regulatory RNAs -- Gene regulation in development and evolution -- Genome analysis and systems biology -- Techniques of molecular biology -- Model organisms.
  • The SARS outbreak in 2002 caused unprecedented devastation and exhibited unusually high rates of morbidity and mortality. For the SARS coronavirus, the transmission vehicle was man. What added to the spread was man's convenient, rapid and affordable ways of travel that caused the virus to spread globally in a short span of time. The SARS coronavirus jumped the species barrier, similar to many recent zoonotic diseases, avian flu, swine flu, Nipah and encephalitis virus. It is extremely important for us to understand the enemy before it strikes again in order to be able to combat such outbreaks as and when they occur. Molecular mechanisms that the virus exploits within its host and that result in infection and pathogenesis are the key to being able to block its transmission cycle. In this book, leading scientists from around the globe have discussed molecular aspects of viral entry, replication, viral gene expression, pathogenesis and host immune response against the SARS coronavirus.
  • This book presents the cellular details and the basic molecular biology approaches for understanding cardiac valvular disease. It provides novel cellular targets for developing future clinical trials and comprehensive clinical discussion of this expanding field. Molecular Biology of Valvular Heart Disease will guide physicians on the potential medical therapies to treat valvular heart disease while providing a platform for cellular targeting of valvular heart disease. Residents and fellows in cardiology, interventional cardiology, cardiac surgery, and current and future valve biologists alike will find this book to be an invaluable resource for developing further interest and understanding of the cellular basis for cardiac valvular disease treatment.
  • 2012 ClinicalKey
  • Unit 1. Basic Chemical and Biological Principles -- Unit 2. The Genome -- Unit 3. The Central Dogma of Molecular Biology -- Unit 4. Regulating Gene Expression -- Unit 5. Subcellular Life Forms -- Unit 6. Changing the DNA Blueprint.
  • This volume of the series Biophysics for the Life Sciences focuses on the conceptual framework and major research tools of contemporary molecular biophysics. It is designed to enable non-specialists -both students and professionals in other fields - to understand how these approaches can be used across the biosciences and in medicine, agriculture, biotechnology, pharmaceutical development and other fields. The scope of this volume is appropriate for advanced undergraduate and graduate courses in biophysics and biophysical chemistry. The book begins with an overview of the development of molecular biophysics and a brief survey of structural, physical, and chemical principles. Subsequent chapters written by experts present, with examples, the major experimental methods: optical spectroscopy, X-ray and neutron diffraction and scattering, nuclear magnetic resonance, electron paramagnetic resonance, mass spectrometry, and single molecule methods. The relationship between the biophysical properties of biological macromolecules and their roles as molecular machines is emphasized throughout and illustrated with three examples DNA helicases, rotary motor ATPases, and myosin.The concluding chapter discusses future prospects in X-ray and neutron scattering, mass spectrometry, and pharmaceutical development.
  • Carcinogens and mutagens -- Whole animal carcinogenicity bioassays -- Molecular mechanisms of action of selected organic carcinogens -- Binding of carinogens to DNA and covalent adducts and DNA damage - PAH, aromatic amines, nitro-aromatic compounds, and halogenated compounds -- Cellular oncogenes and carcinogenesis -- Tumor suppressor genes -- Hepatitis B, Hepatitis C, and hepatocellular carcinoma -- Oncongenesis in transgenic and knockout mice -- Chemically induced morphological and neoplastic transformation in C3H/10T1/2 C1 8 mouse embryo cells -- Radiation carcinogenesis -- DNA microarrays and computational analysis of DNA microarray data in cancer research -- Application of proteomics in basic biological sciences and cancer -- Overview of human cancer induction and human exposure to carcinogens -- Complex mixtures of chemical carcinogens: principles of action and human cancer -- Lung cancer -- Breast cancer -- Cancer of the prostate - Mechanisms of molecular carcinogenesis -- Skin cancer: epidemiology, clinical manifestations, and genetic and molecular aspects -- Cell and molecular biology of cancer of the brain --Thyroid cancer: molecular biology and clinical aspects -- Chemoprevention of chemical carcinogenesis and human cancer -- Carcinogen biomarkers and exposure assessment -- Risk assessment for chemical carcinogens -- Prevention and regulation approaches to carcinogens.
  • Introduction to methods in molecular cardiology / Zhongjie Sun -- Gene therapy approaches to cardiovascular disease / J. Mark Jones and Walter J. Koch -- Gene therapy for myocardial ischemia using hypoxia inducible double plasmid / Yi Tang -- Cardiac gene delivery using dna-adenoviral constructs / J. Mark Jones and Walter J. Koch -- Manipulation of neuronal nitric oxide synthase within the paraventricular nucleus using adenovirus and antisense technology / Yi-Fan Li ... [et al.] -- TAT-mediated protein transduction: delivering biologically active proteins into the heart / Asa B. Gustafson, Roberta A. Gottlieb, and David J. Granville -- Expression of human eNOS in cardiac and endothelial cells / Xiuqing Wang and Zhongjie Sun -- Strategies of conditional gene expression in myocardium: an overview / Heather Heine ... [et al.] -- Gene silencing method using adenoviral RNAi vector -- In cardiomyocytes and vascular smooth muscule cells / Hideko Kasahara and Hiroki Aoki -- Cardiac commitment of embryonic cells for myocardial repair / Dana Zeineddine ... [et al.] -- Autologous mesenchymal stem cells for post ischemic myocardial repair / Yao Liang Tang -- Cellular therapy with autologous skeletal myoblasts for ischemic heart disease and heart failure / Yao Liang Tang -- Protocols for myocardial infarction repair using fetal cardiac myocytes / Sharon Etzion ... [et al.] -- Methods for examining stem cells in post ischemic and transplanted hearts / Nana Rezai ... [et al.] -- Endothelial progenitor cell/ex vivo expansion and gene transfer / Hideki Iwaguro and Takayuki Asahara -- Delineation of sequences essential for specific promoter activation during pressure overloaded hypertrophy or factor-induced hypertrophy / Chellam Rajamanickam and Radhakrishnan Jeejabai -- Evaluation of cardiac isoform of 2 macroglobulin as a factor inducing cardiac hypertrophy / Chellam Rajamanickam and Radhakrishnan Jeejabai -- Detection of apoptosis in cardiovascular diseases / Arwen Hunter, Jonathan C. Choy, and David J. Granville -- Detection of cardiac signaling in the injured and hypertrophied heart / Xiaoning Si ... [et al.] -- Affymetrix oligonucleotide analysis of gene expression in the injured heart / Bobby Yanagawa ... [et al.] -- Identification and validation of loci and candidate genes -- Linked to cardiac hypertrophy / Bastien Llamas and Christian F. Deschepper -- Induction and analysis of cardiac hypertrophy in transgenic animal models / Marcos E. Barbosa, Natalia Alenina, and Michael Bader -- Methods for the detection of altered -adrenergic signaling pathways in hypertrophied hearts / Matthew J. Wolf, Hideo Takibana, and Howard A. Rockman -- Transgenic mouse models for cardiac dysfunction by a specific genetic manipulation / Gopal J. Babu and Muthu Periasamy -- Cardiomyocyte defects in diabetic models and protection with cardiac-targeted transgenes / Xia Shen ... [et al.] -- Protocols for cardiac-specific overexpression of angiotensin II type 1 receptor in transgenic rats / Sigrid Hoffmann.
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    Overview: Molecular Cell Biology presents the key concepts in cell biology and their experimental underpinnings. The authors, all world-class researchers and teachers, incorporate medically relevant examples where appropriate to help illustrate the connections between cell biology and health and human disease. As always, a hallmark of MCB is the use of experiments to engage students in the history of cell biology and the research that has contributed to the field. The book contains predominantly color illustrations, with some black-and-white illustrations.
  • Calcium Overloading-Induced Oxidative Stress-Mediated Cellular and Subcellular Remodeling -- Intracellular MMP-2: Role in Normal and Diseased Hearts -- Control of the Mesenchymal-Derived Cell Phenotype by Ski and Meox2: A Putative Mechanism for Postdevelopmental Phenoconversion -- Elevated Na+-H+ Exchanger Expression and Its Role in Myocardial Dise -- Impact of Perinatal Chronic Hypoxia on Cardiac Tolerance to Acute Ischemia -- Stem Cell, MicroRNA and Redox Cycling -- Cardiac Cell Therapy: Present and Future -- Macroscopic and Microscopic Aspects of Cardiac Dysfunction in Congestive Heart Failure -- Cardiac Dysfunction and Metabolism: Unravelling the Molecular Cross-Talk -- Metabolic Remodelling of the Hypertrophied Heart -- Mechanisms for the Regulation of Phospholipase C Gene Expression in Cardiac Hypertrophy -- Molecular Changes in Fatty Acid Oxidation in the Failing Heart -- Cardiolipin Metabolism in Experimental and Human Heart Failure -- Mechanisms Underlying Development of Cardiomyocyte Hypertrophy via Na-H Exchange Stimulation -- The Structural Basis of Cardiac Dysfunction in Human Heart Failure -- Hormonal Mechanisms of Cardiac Remodeling in Heart Failure -- Modulators of Remodeling After Myocardial Infarction -- Phosphodiesterase-5 Inhibitors in Protection Against Doxorubicin-Induced Cardiomyopathy -- Molecular Basis of Pulmonary Hypertension in Left Heart Failure -- Modulation of Gi Protein Expression in Hypertension: Molecular Mechanisms -- Vascular Dysfunction in Heart Disease -- Cellular and Molecular Mechanisms Associated with Salicylate Inhibition of Intimal Hyperplasia Following Balloon Catheter-Induced Vascular Injury -- Involvement of Growth Factor Receptor and Nonreceptor Protein Tyrosine Kinases in Endothelin-1 and Angiotensin II-Induced Signaling Pathways in the Cardiovascular System -- Sarco/Endoplasmic Reticulum Ca2+ Pump Damage by Oxidative Stress: Implications for Ca2+ Entry -- Obesity-Hypertension: Leptin as the Common Link to Cardiovascular and Renal Dysregulation -- Cardiorenal Protection in Diabetes Mellitus -- Molecular Mechanisms in the Pathogenesis of Diabetic Cardiomyopathy.

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