- Laboratory and diagnostic tests with nursing implications. 8th ed. — Lead optimization for medicinal chemists : pharmacokinetic properties of functional groups and organic compounds (118)
- Leadership in healthcare — LGBT psychology : research perspectives and people of African descent (118)
- Lgr5+ intestinal stem cells and their maintenance — Liver disease in children. 3rd ed. (118)
- Liver immunology : principles and practice. Second edition. [2nd ed.] — Lysosomes and lysosomal diseases (117)
- 2014 SpringerM. Eric Gershwin, John M. Vierling and Michael P. Manns, editors.Liver Immunology: Principles and Practice, Second Editionbegins with important information about the epidemiology and mortality of liver disease worldwide. This information is followed by chapters related to basic immunology, application of liver immunology for diagnosis, and several excellent chapters thatprovide a solid foundation for understanding immune-mediated liver disease, including those associated with the biliary tree. A chapter on non-hepatic manifestations of immune mediatedliver disease helps provide context for how these diseases affect the patient overall. In addition, chapters discuss various discrete immunologically-mediated infectious liver disorders including those related to bacteria, parasites, and all of the classic viruses. Chapters on the traditional autoimmune liver diseases -- primary biliary cirrhosis, autoimmune hepatitis, primary sclerosing cholangitis as well as overlap syndrome are also included. The breadth of this comprehensive second edition is highlighted by chapters on alcoholic liver disease, non-alcoholic fatty liver disease, and drug-induced liver disease, among others. This invaluable new edition ends with a forward-looking view of future directions and how the field might meet the challenge of refractory patients. Developed by a renowned group of authors, Liver Immunology: Principles and Practice, Second Editionwill again serve as a comprehensive textbook by providing an excellent overview for this rapidly evolving field. It greatly adds to the understanding of the pathogenesis of these diseases, while also providing novel insights that can be harnessed into helping improve the care of patients afflicted with various immune-mediated diseases. This volume will again be a must-read for clinicians at all levels, investigators and students.
- 2007 Springeredited by M. Eric Gershwin, John M. Vierling and Michael P. Manns.
- 2016 Springeredited by Hiromasa Ohira.Part I. Basics -- Chapter 1. Innate Immunity and Liver -- Chapter 2. Microbiota and Liver -- Chapter 3. Spleen and Liver -- Chapter 4. The Brain and Liver -- Chapter 5. Glucose Metabolism and Liver -- Chapter 6. Lipid Metabolism and the Liver -- Chapter 7. Metal Metabolism and Liver -- Part II. Clinical Research -- Chapter 8. Metabolic Syndrome and Liver -- Chapter 9. Heart Diseases and Liver -- Chapter 10. Respiratoly Diseases and Liver -- Chapter 11 Physiological and Pathological Interactions Between Liver and Kidney -- Chapter 12. Endocrine Diseases and Liver -- Chapter 13. Rheumatic Diseases and the Liver -- Chapter 14. Hematologic Diseases and Liver -- Chapter 15. IgG4-related Diseases and the Liver -- Chapter 16. Infectious Diseases (Non-hepatitis Virus Infection) and Liver.
- 2015 CRCnetBASEedited by Oren Tirosh.Clinical aspects of nonalcoholic fatty liver disease / Noa Mashav and Oren Shibolet -- Fatty liver vulnerability to hypoxic and inflammatory stress / Rabindra Dhital and Oren Tirosh -- Development of hepatocellular carcinoma / A. Ruth He and Lopa Mishra -- Cellular stress responses in the regulation of drug-induced liver steatosis / Dotan Uzi, Duah Alkam, and Boaz Tirosh -- The role of the Keap1/Nrf2 pathway in the development and progression of nonalcoholic fatty liver disease / Dionysios V. Chartoumpekis and Thomas W. Kensler -- Methionine adenosyltransferase genes in liver health and disease / Komal Ramani and Shelly C. Lu -- Role and modulation of nitric oxide in the cirrhotic liver / Jordi Gracia-Sancho, Juan Carlos García-Pagán, and Jaime Bosch -- Role of mitochondria in alcoholic liver disease and nonalcoholic fatty liver disease / Nicole Rubin, Ho Leung, Jacob E. Valk, Stephen M. Wertheimer, and Derick Han -- Nutritional induction of nonalcoholic fatty liver disease / Noga Budick-Harmelin, Michal Aharoni-Simon, and Zecharia Madar -- The double-edged sword of hepatic iron metabolism in health and diseases / Guiliano Ramadori and Ihtzaz Ahmed Malik -- Diet and lifestyle changes as treatment for nonalcoholic fatty liver disease / Shira Zelber-Sagi -- Role of antioxidants in the nonalcoholic fatty liver disease spectrum / Tommy Pacana and Arun J. Sanyal -- Omega-3 fatty acids and nonalcoholic fatty liver disease / Christopher M. Depner, Kelli A. Lytle, Sasmita Tripathy, and Donald B. Jump -- Nutraceuticals in the prevention and treatment of fatty liver disease / Anna Aronis.
- 2009 SpringerJean-Nicolas Vauthey ... [et al.], editors.
- 2011 Springeredited by Pnina Brodt.Liver metastases are a frequent and often fatal occurrence in cancer patients, particularly those with malignancies of the gastrointestinal (GI) tract. While recent improvements in surgical techniques and a more aggressive approach to resection of liver metastases have improved long term survival for some patients, most patients with hepatic metastases still succumb to their disease. To improve these dismal statistics, a better understanding of the biology of liver metastasis, particularly the early stages that can be targeted for prevention, is essential. Once cancer cells enter the liver, several different scenarios may occur. The cancer cells may be immediately destroyed by local defence mechanisms, they may enter a state of dormancy as solitary cells and never produce a metastasis, initiate a short-lived process of proliferation that is aborted before a metastasis is established or actively proliferate to form macrometastases. The chapters in Part I of this book provide insight into the cellular/molecular mechanisms that determine which of these scenarios prevails. Written by experts researchers in the filed of metastasis, these chapters provide state-of-the art reviews on the cellular and molecular processes that impact the early stages of the metastatic process. The unique microenvironment of the liver, its various anatomical, cellular and molecular features and the impact they have on metastasis are highlighted. In addition, the role of inflammation (pre-existing and tumor-induced), host innate and adaptive immune responses, cytokines, chemokines, growth factors and the unique molecular signatures of metastatic tumor cells are reviewed with an underscoring of the translational implications of the current state of knowledge. Against this background, the chapters in Part II of the book provide critical reviews on major aspects of the clinical management of hepatic metastases. These include imaging strategies, surgical and chemotherapeutic treatment approaches and the use of targeted biological therapeutics such as anti-angiogenic drugs as treatment modalities. By combining information on biological and clinical aspects of liver metastasis, this volume will serve as an excellent resource for scientists, clinicians, clinician/ scientists and trainees in the domains of oncology, surgical oncology, hepatobiliary physiology and radiology.
- 2015 SpringerShahid M. Hussain, Michael F. Sorrell ; forewords by Willis C. Maddrey and Richard C. Semelka.
- 2007 SpringerShahid M. Hussain ; forewords by John L. Gollan and Richard C. Semelka.
- 2015 SpringerMaura O'Neil, Ivan Damjanov, Ryan M. Taylor.
- 2012 Springer Protocolsedited by Djuro Josic, Douglas C. Hixson.Cell surface capturing technologies for the surfaceome discovery of hepatocytes / Damaris Bausch-Fluck, Andreas Hofmann, and Bernd Wollscheid -- On-target desalting and concentration sample preparation protocol for MALDI-MS and MS/MS analysis / Xumin Zhang [and others] -- Plasma membrane isolation using immobilized concanavalin A magnetic beads / Yu-Chen Lee [and others] -- Analysis of the cattle liver proteome by high-sensitive liquid chromatography coupled with mass spectrometry method / Anna Maria Timperio, Gian Maria D'Amici, and Lello Zolla -- Producing a one-dimensional proteomic map for human liver cytochromes P450 / Natalia A. Petushkova and Andrey V. Lisitsa -- Assessing heterogeneity of peroxisomes : isolation of two subpopulations from rat liver / Markus Islinger [and others] -- Purification and proteomic analysis of liver membrane Skeletons / Jintang He [and others] -- Liver plasma membranes : an effective method to analyze membrane proteome / Rui Cao and Songping Liang -- Quantitative analysis of liver golgi proteome in the cell cycle / Xuequn Chen, Philip C. Andrews, and Yanzhuang Wang -- Glycoproteins and glycosylation : apolipoprotein C3 glycoforms by top-down MALDI-TOF mass spectrometry / Yan Zhang, Alan R. Sinaiko, and Gary L. Nelsestuen -- Phosphoproteomic analysis of liver homogenates / Gokhan Demirkan, Arthur R. Salomon, and Philip A. Gruppuso -- Combination of affinity chromatography, 2D DIGE and mass spectrometry to analyze the phosphoproteome of liver progenitor cells / Enrique Santamaria [and others] -- Identifying acetylated proteins in mitosis / Carol Chuang and Li-yuan Yu-Lee -- Comparative proteome analysis of a human liver cell line stably transfected with hepatitis D virus full-length cDNA / Celso Cunha and Ana V. Coelho -- Identification of new autoimmune hepatitis-specific autoantigens by using protein microarray technology / Lin Wu and Guang Song -- Proteomics analysis of human nonalcoholic fatty liver / Eva Rodriguez-Suarez, Jose M. Mato, and Felix Elortza -- Proteomic methods for biomarker discovery in a rat model of alcohol steatosis / Billy W. Newton [and others] -- Targeted mass spectrometry-based metabolomic profiling through multiple reaction monitoring of liver and other biological matrices / Angelo D'Alessandro, Federica Gevi, and Lello Zolla -- Discovery of lamin B1 and vimentin as circulating biomarkers for early hepatocellular carcinoma / Kwong-Fai Wong and John M. Luk -- Combinatorial peptide ligand libraries to discover liver disease biomarkers in plasma samples / Gian Maria D'Amici [and others] -- Isolation of urinary exosomes from animal models to unravel noninvasive disease biomarkers / Javier Conde-Vancells and Juan M. Falcon-Perez.
- 2014 Springeredited by José Ignacio Bilbao, Maximilian F. Reiser.This is the second edition of a very well received book devoted specifically to the treatment of liver tumors by radioembolization with 90Y microspheres. The success of the first edition was based on the provision of all the fundamental information required for successful use of this therapeutic modality in clinical practice. The new edition has been fully updated to cover the most recent advances and includes additional chapters on regulations and emerging trends. Detailed information is provided on the full range of relevant topics, including hepatic vascular anatomy (including variants), dosimetry, assessment of tumor response, and the results achieved using radioembolization alone and in combination with other treatments in patients with primary or metastatic disease. Complications and side-effects are also fully discussed. This book will prove immensely valuable for both beginners and practitioners.
- 2008 SpringerJ.I. Bilbao and M.F. Reiser (eds.).
- 2012 Springer Protocolsedited by Takahiro Ochiya.Purification and culture of fetal mouse hepatoblasts that are precursors of mature hepatocytes and biliary epithelial cells / Nobuyoshi Shiojiri and Miho Nitou -- Clinical uses of liver stem cells Clinical uses of liver stem cells / Yock Young Dan -- Identification and isolation of adult liver stem/progenitor cells / Minoru Tanaka and Atsushi Miyajima -- Isolation and purification method of mouse fetal hepatoblasts / Luc Gailhouste -- Isolation of hepatic progenitor cells from the galactosamine-treated rat liver / Norihisa Ichinohe, Junko Kon, and Toshihiro Mitaka -- Purification of adipose tissue mesenchymal stem cells and differentiation toward hepatic-like cells / Agnieszka Banas -- Development of immortalized hepatocyte-like cells from hMSCs / Adisak Wongkajornsilp, Khanit Sa-ngiamsuntorn, and Suradej Hongeng -- Isolation of adult human pluripotent stem cells from mesenchymal cell populations and their application to liver damages / Shohei Wakao [and others] -- Generation and hepatic differentiation of human iPS cells / Tetsuya Ishikawa, Keitaro Hagiwara, and Takahiro Ochiya -- Efficient hepatic differentiation from human iPS cells by gene transfer / Kenji Kawabata, Mitsuru Inamura, and Hiroyuki Mizuguchi -- "Tet-on" system toward hepatic differentiation of human mesenchymal stem cells by hepatocyte nuclear factor / Goshi Shiota and Yoko Yoshida -- SAMe and HuR in liver physiology / Laura Gomez-Santos [and others] -- Transdifferentiation of mature hepatocytes into bile duct/ductule cells within a collagen gel matrix / Yuji Nishikawa -- Identification of cancer stem cell-related microRNAs in hepatocellular carcinoma / Junfang Ji and Xin Wei Wang -- Intravenous human mesenchymal stem cells transplantation in NOD/SCID mice preserve liver integrity of irradiation damage / Moubarak Mouiseddine [and others] -- Engineering of implantable liver tissues / Yasuyuki Sakai [and others] -- Mesenchymal stem cell therapy on murine model of nonalcoholic steatohepatitis / Yoshio Sakai and Shuichi Kaneko.
- 2010Won Jae Lee.Use of hydrogels as a scaffold material for engineered tissues has been of increasing interest due to their structural similarity to the extracellular components in the body. Photopolymerizable poly(ethylene glycol) (PEG) is one of the most extensively utilized hydrogels, because its network structure can be easily modified to mimic critical aspects of the original microenvironments and its patternability by photolithography or microfluidic devices allows microarchitectures to guide cells' behavior with respect to morphology, cytoskeletal structure, and functionality. However, due to its complicated microenvironments designed to perform the broad range of hepatic functions, development of an engineered liver tissue has been challenging. The three aspects of tissue's microenvironments, which were critical to design PEG-based engineered livers, were addressed. The first aspect was to understand interaction between the PEG network and incorporated cells. Even though the survivability of encapsulated cells was known to depend on diffusion conditions, insufficient understanding of the structure of cell-encapsulated PEG networks has limited development of new networks with improved permeability to support metabolic activities of encapsulated cells. Since network defects have been identified as up to orders of magnitude larger than the mesh size, we suggest that the level of network defects is a primary determinant of hydrogel permeability and its consequent ability to support metabolic activities of encapsulated cells. We therefore sought a way to purposefully augment the network defects by incorporating hydrophobic poly(lactic-co-glycolic acid) (PLGA) nanoparticles, which induce loose crosslinking at the particle-PEG interface. The efficiency of the proposed design strategy was verified by the improved viability and hepatic functions of encapsulated human liver-derived cells. The second aspect was to recapitulate key aspects of tissue architecture. In the liver, and many other tissues also, different types of cells distribute with specific configurations and their interactions are of fundamental importance in physiology, pathophysiology, cancer, developmental biology, and wound healing. In this study, we sought a novel method to guide cells' spatial displacement by applying soft lithography. We first verified that our new network design has the improved permeability without compensating the patternability. Due to the structural advantages, we demonstrated that our simplified patterning process avoided negative influence to encapsulated cell viability and allowed reliable control over distribution of incorporated cells. The third aspect was to provide a platform to reliably provide biological factors to encapsulated cells in PEG matrices. Because most biomolecules easily lose their therapeutic potency and have specific plasma levels for optimal clinical efficacies, drug delivery systems have been designed to deploy medications intact through a protective medium that can also control the rate of drug release. In this system, we utilized PLGA particles, which were used to improve the permeability, as drug carriers. However, due to the complexity of the release mechanism and the complicated interplay between various design parameters of the release medium, detailed prediction of the resulting release profile is a challenge. Herein we suggest a simple method to target specific release profiles more efficiently by integrating release profiles for an array of different microsphere types. This scheme is based on our observation that the resulting release profile from a mixture of different samples can be predicted as the linear summation of the individually measured release profiles of each sample. Hence, by employing a linear equation at each time point and formulating them as a matrix equation, we could determine how much of each microsphere type to include in a mixture in order to have a specific release profile. In accordance with this method, several targeted release profiles were successfully obtained.
- 2009 Springeredited by Gregory T. Everson and James F. Trotter.
- 2014 SpringerJennifer Steel, editor.The inadequate supply of organs in the United States and other countries continues to drive the reliance on living donor transplantation. Representatives of the transplant community convened for a meeting on living donation in an effort to provide guidelines to promote the welfare of living donors. The consensus statement that resulted from this meeting recommended that transplant centers retain an Independent Living Donor Advocate (ILDA) to focus on the best interest of the donor. Over a decade later, nearly every transplant center in the United States, performing living donor surgeries, has incorporated an ILDA into their living donor screening and/or evaluation process, however there are no guidelines with regard to the ILDA's qualifications, clinical practice, or how address ethical challenges.
- 2013The findings suggest that the U.S. public is not particularly worried about the gradual rise in the number of older Americans. Nearly nine-in-ten adults surveyed say that "having more elderly people in the population" is either a good thing for society (41%) or does not make much difference (47%). Just 10% see this trend as a bad thing.
- 2007 SpringerClive Handler, Gerry Coghlan ; foreword by Dame Carol Black.
- 2013Corinne Squire, School of Law and Social Sciences, University of East London, UK.
- Living with HIV and dying with AIDS : diversity, inequality, and human rights in the global pandemic2013 ebraryLesley Doyal with Len Doyal.
- 2013Mical Raz."The rise and widespread acceptance of psychosurgery constitutes one of the most troubling chapters in the history of modern medicine. By the late 1950s, tens of thousands of Americans had been lobotomized as treatment for a host of psychiatric disorders. Though the procedure would later be decried as devastating and grossly unscientific, many patients, families, and physicians reported veritable improvement from the surgery; some patients were even considered cured. 'The Lobotomy Letters' gives an account of why this controversial procedure was sanctioned by psychiatrists and doctors of modern medicine. Drawing from original correspondence penned by lobotomy patients and their families as well as from the professional papers of lobotomy pioneer and neurologist Walter Freeman, the volume reconstructs how physicians, patients, and their families viewed lobotomy and analyzes the reasons for its overwhelming use." -- [Publisher-supplied data]
- 2014 WileyRui Fernandes.Flap classification -- Bilobed flap -- Rhomboid flap -- Crescentic flap -- Septal flap -- Nasolabial flap -- V to Y advancement flap -- Keystone flap -- Paramedian forehead flap -- The temporoparietal fascia flap -- Temporalis muscle flap -- Cervicofacial advancement flap -- Submental island flap -- Pectoralis major myocutaneous flap -- Latissimus dorsi myocutaneous flap -- Sternocleidomastoid flap -- Trapezius flap -- The supraclavicular artery island flap -- The internal mammary perforator flap -- Ear reconstruction -- Lip reconstruction -- Nasal reconstruction -- Scalp reconstruction.
- 2006 Springeredited by Edward D. Frohlich and Richard N. Re.
- 2009 SpringerEdward D. Frohlich, Richard N. Re, editors.
- 2015 SpringerVelupillai Ilankovan, Madan Ethunandan, Tian Ee Seah.Local anaesthesia -- Aesthetic & reconstructive units -- Decision making process / defect assessment -- Individual flaps -- Reconstruction of specific sites.
- 2007[edited by] Shan R. Baker.
- 2014 ClinicalKey[edited by] Shan R. Baker.Local Flaps in Facial Reconstruction brings you the detailed visual guidance and unmatched expertise you need to achieve the best results for the full range of facial flap procedures. Full-color clinical photographs and line drawings-along with high-quality surgical video clips-capture the latest facial reconstruction practices and effective methods like reconstruction of skin defects on the head and neck following tumor removal or trauma. Perspectives from facial plastic surgeons, dermatologists, ophthalmologists, and otolaryngologists help you take all of these considerations into account in treatment planning. Make the most effective clinical decisions with a better understanding of the anatomy, physiology, and biomechanics of the skin Understand skin flap anatomy and physiology-vital to the performance of successful local flap reconstruction for facial defects.
- 2003 Kargervolume editors: Udo R. Markert, Peter Elsner.Also available: Print – 2003
- 2006 Kargervolume editors, Michael Heinrich, Walter E. Müller, Claudio Galli.Ethnobotany -- 'Local food-nutraceuticals': bridging the gap between local knowledge and global needs / Heinrich, M. ... [et al.] -- Gathered Mediterranean food plants: ethnobotanical investigations and historical development / Rivera, D. ... [et al.] -- Disseminating knowledge about 'local food plants' and 'local plant foods' / Rivera, D. ... [et al.] -- Biological activities of 'local foods' -- Plant foods and brain aging: a critical appraisal / Schaffer, S. ... [et al.] -- Local food and cardioprotection: the role of phytochemicals / Visioli, F. ... [et al.] -- A vegetable to meat consumption ratio as a relevant factor determining cancer preventive diet. The Mediterranean versus other European countries / Kapiszewska, M. -- Mediterranean diet as a nutrition education and dietary guide: misconceptions and the neglected role of locally consumed foods and wild green plants / Manios, Y. ... [et al.] -- Development of bioactive substances for functional foods: scientific and other aspects / Weber, P., Flühmann, B., Eggersdorfer, M.
- 2013investigators, Thomas A. Ratko, Vikrant Vats, Jennifer Brock, B.W. Ruffner, Jr., Naomi Aronson.OBJECTIVES: We prepared this report on the comparative effectiveness and harms of lung-directed nonsurgical therapies for non-small-cell lung cancer (NSCLC) in three distinct patient populations: (1) patients with stage I NSCLC who are not surgical candidates (Key Question 1), (2) patients with stage I NSCLC who are deemed operable but decline surgery (Key Question 2), and (3) patients with endoluminal NSCLC causing obstruction (Key Question 3). For stage I NSCLC, the local nonsurgical interventions could include conformal radiotherapy modalities and radiofrequency ablation (RFA). For patients with airway obstruction due to an endoluminal NSCLC, local nonsurgical interventions could include those for the stage I setting, as well as conventional wide-field radiotherapy, brachytherapy, laser and mechanical debridement, endoluminal stents, cryoablation, and photodynamic therapy. Surgical resection of any type is not considered as a comparator for any of the Key Questions. DATA SOURCES: MEDLINE(r), Embase(r), and the Cochrane Controlled Trials Registry were searched from January 1, 1995, to July 25, 2012. A search of the gray literature included databases with regulatory information, clinical trial registries, abstracts and conference papers, and information from manufacturers. REVIEW METHODS: We sought studies reporting overall survival, cancer-specific survival, local control, symptom relief, adverse events, and quality of life among our populations of interest. Data were abstracted for each Key Question by a team of reviewers, with independent data verification. Study quality and the risk of bias of randomized controlled trials (RCTs) were assessed using the United States Preventive Services Task Force criteria. The quality and risk of bias of single-arm studies were assessed using the Carey and Boden criteria. The strength of the body of evidence was assessed according to the Agency for Healthcare Research and Quality Methods Guide. RESULTS: In our searches, we identified 4,648 unique titles and screened 1,178 in full text. Of the latter, 55 met the inclusion criteria. Thirty-five studies were relevant to Key Question 1, considering medically inoperable patients with stage I NSCLC; 6 were relevant to Key Question 2, considering medically operable patients with stage I NSCLC who decline surgery; and 17 were relevant to Key Question 3, considering patients with inoperable endoluminal NSCLC causing symptoms of obstruction. Three studies addressed both Key Questions 1 and 2. All studies relevant to Key Questions 1 and 2 were single-arm design, prospective (n=15), retrospective (n=21), or not specified (n=2). Among 17 papers included for Key Question 3, 5 were RCTs, 1 was a nonrandomized comparative study, and 11 were single-arm studies. Because comparative study evidence on RFA and debridement and stenting was unavailable for Key Question 3, we included evidence from two single-arm studies involving stents and one on RFA. All RCTs were of poor quality. Only one comparison was available per study, with no two studies examining the same set of interventions. Outcomes of therapy for all Key Questions included overall survival, adverse effects, and quality of life. CONCLUSIONS: Evidence on localized nonsurgical therapies for patients with stage I NSCLC who are not surgical candidates or who decline surgery consists only of single-arm studies, with no direct comparisons among interventions. The best evidence for NSCLC patients with endoluminal obstruction consists of poor-quality single RCTs for each comparison; we did not identify evidence that permitted us to draw conclusions based on indirect comparisons. Overall, evidence is insufficient to permit conclusions on the comparative effectiveness of local nonsurgical therapies for inoperable or operable patients with stage I NSCLC or inoperable NSCLC patients with endoluminal tumor causing pulmonary symptoms.
- 2015 SpringerWillm Uwe Kampen, Manfred Fischer, editor.This book presents a systematic survey of different local treatments in inflammatory joint diseases and their potential side effects and complications. Both surgical therapies and pharmaceutical strategies involving local or systemic application of anti-inflammatory and immunomodulating drugs are addressed. Special emphasis is placed on nuclear medicine therapy by intra-articular instillation of beta radiation emitters, known as radiosynoviorthesis or radiation synovectomy. Possible complications, in particular radionecrosis, infection, and thromboembolism, are described and available treatment strategies are examined in detail. In addition, radiation safety considerations are critically reviewed and relevant clinical questions are discussed. While radiosynoviorthesis is an effective and safe treatment if a proper indication is secured and if the application is performed by an experienced nuclear medicine physician, local complications can never be excluded with certainty. This book will support physicians who are engaged in the care and treatment of patients with inflammatory joint disease, approximately 30,000 of whom undergo radiosynoviorthesis in Europe each year. .
- 2011Peter Leader Lee.Membrane trafficking is an essential process that enables cells to deliver proteins to the extracellular space and segregate proteins into different compartments. Several steps are necessary for the functional segregation and processing of proteins. Trafficking includes post-translational modification of proteins, their movement between compartments, and stable localization once they have reached their target destinations. Importantly, membrane trafficking represents a recursively-sustained system: proteins that play a role in the regulation of membrane trafficking must also be properly transported and localized. Chapter one introduces the importance of the Golgi in the sorting and packaging of proteins and the roles of molecular motors in facilitating individual transport events. To modify transported cargoes, Golgi resident glycosyltransferases need to be localized to the correct cisternae and in some cases, in correct complex with other glycosyltransferases. "Kin recognition", the association of enzymatically compatible glycosyltransferases, has been demonstrated as a mechanism for the stable localization of glycosyltransferases to their proper compartments. Myosins, dyneins, and kinesins, linked to membranes by small Rab GTPases and their effectors, play important roles in moving cargo on actin and microtubule filaments. Their regulation by adapter proteins and their combinatorial interactions both complementing and opposing movement allows for the fine tuning of cargo transport. Chapter two presents the association of UDP-GlcNAc:[beta]Gal [beta]-1,3-N-acetylglucosaminyltransferase 1 (B3GNT1) and UDP-Gal:[beta]GlcNAc [beta]-1,4-galactosyltransferase, polypeptide 1 (B4GALT1). These two glycosyltransferases participate in the alternating, successive polymerization of poly-N-acetyllactosamine (polyLacNAc), a linear carbohydrate polymer composed of alternating N-acetylglucosamine and galactose residues. We show that these two glycosyltransferases colocalize by immunofluorescence microscopy, interact by coimmunoprecipitation, and when artificially retained in the ER can retain the complementary glycosyltransferase there as well. Chapter three presents the novel regulation of the KIF3 family kinesin, KIF1C, by small Rab GTPases, Rab1 and Rab6. The depletion of KIF1C impairs the plasma membrane delivery of Vesicular stomatitis virus G protein and intriguingly increases the speed of both Rab1 and Rab6 labeled vesicles. Rab6 can bind directly to the C-terminal domain of KIF1C and, like Rab1, can additionally interact with KIF1C's N-terminal motor domain. The interaction of KIF1C with Rab6 diminishes KIF1C's ability to bind microtubules. These results suggest that KIF1C acts as a brake, perhaps slowing transport to allow proper packaging and tethering to occur. Our data suggest that interaction between Rab6 and KIF1C could relieve KIF1C's braking action by displacing it from microtubules; alternatively, KIF1C may function as a molecular tether between membranes carrying Rab1 and/or Rab6.
- 2011 OvidPaul W. Brazis, Joseph C. Masdeu, José Biller.General principles of neurologic localization -- Peripheral nerves -- Cervical, brachial, and lumbosacral plexi -- Spinal nerve and root -- Spinal cord -- Cranial nerve I (the olfactory nerve) -- Visual pathways -- Localization of lesions affecting the ocular motor system -- Cranial nerve V (the trigeminal nerve) -- Cranial nerve VII (the facial nerve) -- Cranial nerve VIII (the vestibulocochlear nerve) -- Cranial nerve IX and X (the glossopharyngeal and vagus nerves) -- Cranial nerve XI (the spinal accessory nerve) -- Cranial nerve XII (the hypoglossal nerve) -- Brainstem -- Cerebellum -- Localization of lesions affecting the hypothalamus and pituitary gland -- Anatomic localization of lesions in the thalamus -- Basal ganglia -- Localization of lesions affecting the cerebral hemispheres -- Localization of lesions in the autonomic nervous system -- Vascular syndromes of the forebrain, brainstem, and cerebellum -- Localization of lesions causing coma.
- 2007 OvidPaul W. Brazis, Jose C. Masdeu, José Biller.General principles of neurologic localization -- Peripheral nerves -- Cervical, brachial, and lumbosacral plexi -- Spinal nerve and root -- Spinal cord -- Cranial nerve I (the olfactory nerve) -- Visual pathways -- The localization of lesions affecting the ocular motor system -- Cranial nerve V (the trigeminal nerve) -- Cranial nerve VII (the facial nerve) -- Cranial nerve VIII (the vestibulocochlear nerve) -- Cranial nerves IX and X (the glossopharyngeal and vagus nerves) -- Cranial nerve XI (the spinal accessory nerve) -- Cranial nerve XII (the hypoglossal nerve) -- Brainstem -- The cerebellum -- The localization of lesions affecting the hypothalamus and pituitary gland -- The anatomic localization of lesions in the thalamus -- Basal ganglia -- The localization of lesions affecting the cerebral hemispheres -- Vascular syndromes of the forebrain, brainstem, and cerebellum -- The localization of lesions causing coma.Also available: Print – 2007
- Localized regulation of the anaphase-promoting complex by the Emi1/NuMA/Dynein-dynactin (END) network2007Kenneth Ban.
- 2015 SpringerEric Van Cutsem, Thomas J. Vogl, Vranco Orsi, Alberto Sobrero, editors.Basics of Regional Tumor therapies: Locoregional Tumor Therapies, Evidence and Future -- Pharmacokinetic of Locoregional Tumor Therapies -- Embolization Materials, Catheter, IA-port systems Indications for locoregional tumor therapies ? Liver: HCC -- Liver Metastases of CRC- Liver Metastases of Neuroendocrine Tumors and CCC -- Liver metastases of other indications: Pancreas Carcinoma -- Melanoma -- Breast Carcinoma. Indications for locoregional tumortherapies ? Lung: Basics -- Primary Lung Tumors -- Lung metastases Thermoablation: Liver -- Lung. Head and Neck.
- 2009 SpringerG. Hughes.
- 2012 SpringerJeremy C. Wright, Diane J. Burgess, editors.
- 2016 SpringerErwei Song, editor.Non-coding RNAs: New Players in Cancers -- The Working Modules of Long Non-coding RNAs in Cancer Cells -- Methods to Study Long Non-coding RNA Biology in Cancer -- Relationship between Non-coding RNA Dysregulation and Epigenetic Mechanisms in Cancer -- Non-coding RNAs in Growth and Death of Cancer Cells -- Non-coding RNAs in Cancer Cell Plasticity -- Non-coding RNAs in Regulation of Cancer Metabolic Reprogramming -- Non-coding RNAs in Tumor Angiogenesis -- Non-coding RNAs in Cancer Immunity -- Non-coding RNAs in Therapeutic Resistance of Cancer -- Non-coding RNAs Regulating Cancer Signaling Network -- Non-coding RNAs Regulating NFkB Signaling -- Non-coding RNAs Regulating p53 and c-Myc Signaling -- Viral Non-coding RNAs in Cancer Biology -- Non-coding RNAs in Cancer Diagnosis -- Therapeutic Potentials of Non-coding RNAs: Targeted Delivery of NcRNAs in Cancer Cells.
- 2011 SpringerĐurđica Ugarković, editor.Transcriptional and posttranscriptional programming by long noncoding RNAs / Radha Raman Pandey and Chandrasekhar Kanduri -- Long noncoding RNA as a regulator for transcription / Riki Kurokawa -- Long noncoding RNAs and X chromosome inactivation / Cristina Gontan, Iris Jonkers, and Joost Gribnau -- TERRA : long noncoding RNA at eukaryotic telomeres / Rajika Arora, Catherine M.C. Brun, and Claus M. Azzalin -- Transcription of satellite DNAs in mammals / Claire Vourc'h and Giuseppe Biamonti -- Multiple roles of Alu-related noncoding RNAs / Audrey Berger and Katharina Strub -- roX RNAs and genome regulation in Drosophila melanogaster / S. Kiran Koya and Victoria H. Meller -- Transcription of satellite DNAs in insects / Željka Pezer ... [et al.] -- Long nonprotein-coding RNAs in plants / Virginie Jouannet and Martin Crespi.
- 2016 SpringerKevin V. Morris, editor.Understanding the Complex Circuitry of lncRNAs at the X-inactivation Center and its Implications in Disease Conditions -- Long Non-coding RNA ANRIL and Polycomb in Human Cancers and Cardiovascular Disease -- Form and function of exosome associated long non-coding RNAs in cancer -- Long Non-coding RNAs in Lung Cancer -- Pseudogene-expressed RNAs: Emerging roles in gene regulation and disease -- Functional long non-coding RNAs in vascular smooth muscle cells -- Long Non-coding RNAs as Targets and Regulators of Nuclear Hormone Receptors -- Non-coding transcriptional landscape in human aging -- LncRNAs in stress response -- Expression Specificity of Disease-Associated lncRNAs: towards Personalized Medicine. .
- 2002 CRCnetBASEedited by Julien Bogousslavsky.Also available: Print – 2002
- 2006 Springeredited by Zeng Yi ... [et al.].Disability and healthy life expectancy -- Individual healthy aging -- The family and healthy aging -- Community effects on healthy aging.
- 2005 SpringerJ.R. Carey ... [et al.] (eds.).
- 2015 SpringerGil Atzmon, PhD editor.The release of the complete version of the human genome sequence in 2003 has paved the way for defining gene function and genetic background for phenotypic variation in humans and allowed us to study the aging process in a new light. This new volume results from that research and focuses on the genetic and epigenetic process of aging. While the interpretation of the genome data is still in its initial stages, this new volume looks at the evolving understanding of molecular mechanisms involved in cellular processes, gene function associated with complex traits, epigenetic components involve in gene control and the creation of hypothesis-free genome-wide approaches. Longevity Genes: A Blueprint for Aging explores the genetic and genomic elements that can maintain a long life such as DNA damage mechanisms, epigenetics and the way we can use this knowledge to generate customized treatments. It touches on some of the multidisciplinary approaches as well as genomic-wide association technology used to analyze complex traits. This book describes the hunt for genes affecting complex traits using a high throughput technology, with adequate consideration for the selection of an appropriate population, applications of statistical genetics and computational biology, and most importantly, considering phenotype-genotype association studies. Longevity Genes provides coverage of not only established aspects of genetics and aging, but also new approaches and perceptions in this important area of research.Also available: Print – 2015
- Longevity project : surprising discoveries for health and long life from the landmark eight-decade study2011Howard S. Friedman and Leslie R. Martin.We have been told that the key to longevity involves obsessing over what we eat, how much we stress, and how fast we run. Based on the most extensive study of longevity ever conducted, "The Longevity Project" exposes what really impacts our lifespan--including friends, family, personality, and work.
- 2008 CRCnetBASEeditors, Garrett Fitzmaurice ... [et al.].
- 2015Executive Office of the President of the United States, Council of Economic Advisers.The Supplemental Nutrition Assistance Program (SNAP) is the cornerstone of U.S. efforts to alleviate hunger by supplementing the food budgets of low-income households. The large majority of SNAP recipients are children, working parents, elderly Americans, and people with disabilities. SNAP has also played an important role in lifting millions of people -- especially children -- out of poverty for the past five decades. This report provides an overview of the problem of food insecurity in the United States and the important role that SNAP plays in addressing it.
- 2011 Springer[edited by] Pamela Ann Fenstemacher and Peter Winn.Home care -- Assisted living and residential care -- Nursing facilities -- The role of practitioners and the medical director -- Common clinical conditions in long-term care -- Acute changes in condition -- Health maintenance and prevention -- Integrating palliative care into practice -- Weight and nutrition -- Wound care -- Dementia, delirium, and depression -- Ethical and legal issues -- Caring for families -- Documentation and coding -- Medication management in long-term care -- Rehabilitation and maximizing function.
- 2013T. Tompson, J. Benz, J. Agiesta, D. Junius, K. Nguyen, and K. Lowell.Overall, the idea of getting older is something that 3 in 10 Americans 40 years or older would rather not think about at all. Another 32 percent are somewhat comfortable thinking about getting older and 35 percent report being very comfortable. Being older, more educated, and in better health are associated with greater levels of comfort thinking about aging. Sixty-two percent of those 40-54 years old are somewhat or very comfortable thinking about getting older; the percentage increases to 75 percent for those 65 or older. Nearly half of those 65 and older, 47 percent, report being very comfortable thinking about getting older.
- 2015 SpringerKristina Malmgren, Sallie Baxendale, J. Helen Cross, editors.Why a Volume on Long-Term Outcomes of Epilepsy Surgery? -- Methodological Demands on Observational Studies of Outcomes After Epilepsy Surgery -- Long-Term Seizure and Antiepileptic Drug Outcomes After Epilepsy Surgery in Adults -- Long-Term Seizure and Antiepileptic Drug Outcomes After Epilepsy Surgery in Children -- Long-Term Cognitive Outcomes After Epilepsy Surgery in Adults -- Long-term Cognitive Outcomes After Epilepsy Surgery in Children -- Long-Term Psychiatric Outcomes After Epilepsy Surgery in Adults -- Long-Term Psychiatric and Behaviour Outcomes in Children Following Epilepsy Surgery -- Mortality After Epilepsy Surgery -- Long-Term Educational and Vocational Outcomes of Adults After Epilepsy Surgery -- Educational and Employment Outcomes Following Epilepsy Surgery in Childhood -- Quality of Life Outcomes in Adults Following Epilepsy Surgery -- Quality of Life and Psychosocial Outcomes in Children Following Epilepsy Surgery -- Subjective Experiences of Epilepsy Surgery in Adults -- Subjective Experiences of Children and Parents After Epilepsy Surgery -- Informed Consent for Epilepsy Surgery -- Managing Expectations of Epilepsy Surgery -- Health Economic Analyses of Epilepsy Surgery -- Long-Term Outcomes of Epilepsy Surgery: Knowledge Gaps and Future Directions. .
- 2012 SpringerRoberto Walter Dal Negro, Richard Hodder, editors ; forewords by Marc Miravitlles and Dario Olivieri.The Patient Candidate for Long-Term Oxygen Therapy -- The Patient Candidate for Long-Term Oxygen Therapy / Roberto W. Dal Negro, Richard Hodder -- The Multidimensional Evaluation of Patients -- Lung Function Parameters / Cleante Scarduelli -- Cardiovascular and Metabolic Indices / Andrea Corsonello, Claudio Pedone, Simone Scarlata, Raffaele Antonelli Incalzi -- Chronic Obstructive Pulmonary Disease (COPD): Neuromuscular Implications / Cristina Deluca, Ebba Buffone, Elena Minguzzi, Maria Grazia Passarin -- The Psychological and Cognitive Profile / Sonia Dal Ben, Fernanda Bricolo -- Nutritional Deficiencies / Roberto Aquilani, Federica Boschi, Evasio Pasini -- Gender-Related Differences / Paola Turco -- The Cooperating Roles -- Home LTOT: The Role of the Caregiver / Roberta Barian, Stefano Bertacco -- The General Practitioner (GP) / Germano Bettoncelli -- The Cooperating Roles: The Lung Physician / Silvia Tognella -- The Health Institutions / Paola Pisanti -- The Role of Media / Daniel Della Seta -- Systems for Oxygen Delivery / Carlo Castiglioni -- Models for LTOT Management -- Standard Care / Eugenio Sabato, Saverio Sabina, Carlo G. Leo -- Tele-Control at Home / Roberto W. Dal Negro -- The Value of a Systemic Accreditation Path / Massimo Dutto, Nicoletta Palese -- The Outcomes -- Clinical Outcomes / Claudio Micheletto -- Humanistic Outcomes and Quality of Life / Mauro Carone, Sabina Antoniu -- The Economic Impact of Long-Term Oxygen Therapy / Lorenzo G. Mantovani, Marco Cristiani, Gianluca Furneri.
- 2013 ClinicalKeyJames G. Marks, Jr., Jeffrey J. Miller.Introduction -- Structure and function of the skin -- Principles of diagnosis -- Dermatologic therapy and procedures -- Epidermal growths -- Pigmented growths -- Dermal and subcutaneous growths -- Eczematous rashes -- Scaling papules, plaques, and patches -- Vesicles and bullae -- Inflammatory papules -- Pustules -- White spots -- Generalized erythema -- Localized erythema -- Specialized erythema -- Purpura -- Dermal induration -- Ulcers -- Hair disorders -- Nail disorders -- Mucous membrane disorders -- Skin signs of systemic disease -- Self-assessment.Also available: Print – 2013
- 2006James G. Marks, Jr., Jeffrey J. Miller.
- Kidwell, C. S.
- 2014 WorldScientificeditors, Rakesh Srivastava, Wojciech Maksymowicz, Wlodek Lopaczynski.This book is all about the definition and finding ways to prioritize and accelerate translation research in biomedical sciences and rapidly turning new knowledge into first-in-human studies. It represents an effort to bring together scientists active in various areas of translational research to share science and, hopefully, generate new ideas and potential collaborations. The book provides a comprehensive overview of translational work that includes significant discoveries and pioneering contributions, e.g., in immunology, gene therapy, stem cells and population sciences. It may be used as an advanced textbook by graduate students and even ambitious undergraduates in biomedical sciences. It is also suitable for non-experts, i.e. medical doctors, who wish to have an overview of some of the fundamental models in translational research. Managing the translational enterprise remains a work in progress. The world is changing rapidly, and the scientific world needs to seek new ways to ensure that discoveries get translated for patients efficiently and as quickly as possible. In addition, everyone expects the investment in biomedical research should pay dividends through effective therapeutic solutions. This unique project provides a broad collaborative approach of the international scientific team to present its view and opinion how to cross barriers to incentives for translational research in medical sciences. Contributing to the book is an international team of prominent co-authors. The book consists of unique and widely treated topics, and includes new hypotheses, data and analyses.
- 2005 MyiLibraryedited by Todd E. Feinberg, Julian Paul Keenan.The self as a problem in philosophy and neurobiology / John R. Searle -- The cognitive neuroscience of the self: insights from functional neuroimaging of the normal brain / Seth J. Gillihan and Martha J. Farah -- Neural hierarchies and the self / Todd E. Feinberg -- The frontal lobes and self-awareness / Donald T. Stuss ... [et al.] -- Autobiographical disorders / Esther Fujiwara and Hans J. Markowitsch -- Body image and the self / Georg Goldenberg -- Right-hemisphere pathology and the self: delusional misidentification and reduplication / Todd E. Feinberg ... [et al.]. The mirror sign delusional misidentification symptom / Karen Spangenberg Postal -- Disorders of the self in dementia / William W. Seeley and Bruce L. Miller -- Autism -- "Autos": literally, a total focus on the self? / Simon Baron-Cohen -- Recognizing the sensory consequences of one's own actions and delusions of control / Sarah-Jayne Blakemore. The neural correlates of depersonalization: a disorder of self-awareness / Hedy Kober ... [et al.] -- The self in dreams / Antti Revonsuo -- Psychoactive agents and the self / Roy J. Mathew -- Meditation and the self / Hans C. Lou and Troels W. Kjaer -- The enduring self: a first-person account of brain insult survival / J. Allan Hobson.
- 2012Elaine Breslaw.In the years following the American Revolution, as poverty increased and America's water and air became more polluted, people grew sicker. Traditional medicine became increasingly ineffective. Instead, Americans sought out both older and newer forms of alternative medicine and people who embraced these methods: midwives, folk healers, Native American shamans, African obeahs and the new botanical and water cure advocates. Breslaw describes the evolution of public health crises and solutions, and argues that their ascendance over other healers didn't begin until germ theory finally migrated from Europe, and American medical education achieved professional standing.
- 2011 SpringerMary Florentine, Arthur N. Popper, Richard R. Fay, editors."The topic of loudness is of considerable concern both in and outside of research laboratories. Most people have developed an opinion about some aspect of loudness, and many complain about the loudness of background sounds in their daily environments and their impacts on quality of life. Moreover, such sounds interfere with the ability to hear useful sounds, and such masking can be especially problematic for people with hearing losses, children, older adults, and non-native speakers of a language. At the same time, not all loud sounds are undesirable. Some loud sounds are important for human well-being, such as warning signals, whereas other loud sounds, such as music, can be pleasurable. In fact, loudness is essential for enjoying the dynamics of music. Thus, loudness is a pervasive and complex issue, and one that needs to be examined from a wide range of perspectives, and that is the purpose of this volume. Research in loudness has been performed in many countries, and this volume is an international endeavor with authors from Europe, Japan, and the United States, making the volume an attempt to provide a global network of information about loudness. The editors are very pleased to be able to bring together information on many aspects of loudness in this one volume, as well as to highlight approaches from many different perspectives."--Publisher's website.
- Lovell and Winter's Pediatric orthopaedics : editors, Stuart L. Weinstine and John M. (Jack) Flynn.. 7th ed.2014 OvidFlynn, John M.; Lovell, Wood W.; Weinstein, Stuart L.; Winter, Robert B."Now in its updated Seventh Edition, Lovell and Winter's Pediatric Orthopaedics remains a must-have for physicians and residents treating infants, children, and adolescents with orthopaedic problems. This classic, comprehensive reference covers the basic science, clinical manifestations, and management of orthopaedic problems in children. Now in full color, the foremost orthopaedists examine normal musculoskeletal development and the causes, diagnosis, and treatment of the entire range of abnormalities, with emphasis on evidence-based decision making in treatment selection. The clinical chapters include pearls and pitfalls and a description of the author's preferred approach. The book will now cover surgical techniques of management with step-by-step illustrations from the Atlas of Pediatric Orthopaedic Surgery."-- Provided by publisher.
- 2006 Ovideditors, Raymond T. Morrissy, Stuart L. Weinstein.Embryology and development of the musculoskeletal system / Frederick R. Dietz and José A. Morcuende -- Growth in pediatric orthopaedics / Alain Diméglio -- Imaging in pediatric orthopaedics / Geetika Khanna, Georges Y. El-Khoury, and Yusuf Menda -- Evaluation of the medical literature / Mininder S. Kocher -- The pediatric orthopaedic examination / David D. Aronsson -- Genetic aspects of orthopaedic conditions / William G. Cole -- Metabolic and endocrine abnormalities / Benjamin A. Alman and Andrew W. Howard -- The skeletal dysplasias / Paul D. Sponseller and Michael C. Ain -- Syndromes of orthopaedic importance / Benjamin A. Alman and Michael J. Goldberg -- Localized disorders of bone and soft tissue / William G. Mackenzie and Peter G. Gabos -- Diseases of the hematopoietic system / Roger Cornwall and John P. Dormans -- Juvenile idiopathic arthritis / Dowain A. Wright -- Osteomyelitis and septic arthritis / Anthony A. Stans -- Bone and soft tissue tumors / Dempsey S. Springfield and Mark C. Gebhardt -- Cerebral palsy / Thomas S. Renshaw and Peter A. Deluca -- Myelomeningocele / Kenneth J. Noonan -- Other neuromuscular disorders / George H. Thompson and Frank R. Berenson -- Idiopathic scoliosis / Peter O. Newton and Dennis R. Wenger -- Congenital scoliosis / John B. Emans -- Kyphosis / William C. Warner, Jr. -- Spondylolysis and spondylolisthesis / Scott J. Luhmann, Michael F. O'Brien, and Lawrence G. Lenke -- The cervical spine / Randall T. Loder -- The upper limb / Peter M. Waters -- Developmental hip dysplasia and dislocation / Stuart L. Weinstein -- Legg-calvé-perthes syndrome / Stuart L. Weinstein -- Slipped capital femoral epiphysis / Robert M. Kay -- Other conditions of the hip / Matthew B. Dobbs and José A. Morcuende -- The lower extremity / Perry L. Schoenecker and Margaret M. Rich -- Leg-length discrepancy / Colin F. Moseley -- The foot / James R. Kasser -- The child with a limb deficiency / Raymond T. Morrissy, Brian J. Giavedoni, and Colleen Coulter-O'Berry -- Sports medicine in the growing child / R. Baxter Willis -- Management of fractures / Charles T. Price and John M. Flynn -- The role of the orthopaedic surgeon in child abuse / Tom F. Novacheck.Also available: Print – v. 1-2, 2006.
- 2013 Springer Protocolsedited by Helena Bäckvall and Janne Lehtiö.Part I. Low Molecular Weight Analysis Methods. Narrow-Range Peptide Isoelectric Focusing as Peptide Prefractionation Method Prior to Tandem Mass Spectrometry Analysis / Maria Pernemalm -- Analysis of Peptides by Denaturing Ultrafiltrationand LC-MALDI-TOF-MS / Yanming An and Radoslav Goldman -- Stable Isotope Labeling Methods in Protein Profiling / Johan Lengqvist and AnnSofi Sandberg -- Development of MRM-Based Assays for the Absolute Quantitation of Plasma Proteins / Michael A. Kuzyk, Carol E. Parker, Dominik Domanski, and Christoph H. Borchers -- Mass Spectrometric Profiling of Low-Molecular-Weight Proteins / Matthias Rainer, Constantin Sajdik, and Günther K. Bonn -- Developing an iMALDI Method / Brinda Shah, Jennifer D. Reid, Michael A. Kuzyk, Carol E. Parker, and Christoph H. Borchers -- Analysis of Neuropeptides by MALDI Imaging Mass Spectrometry / Anna Ljungdahl, Jörg Hanrieder, Jonas Bergquist, and Malin Andersson -- Highly Multiplexed Antibody Suspension Bead Arrays for Plasma Protein Profiling / Kimi Drobin, Peter Nilsson, and Jochen M. Schwenk -- Part II. Bioinformatics Of Proteomics Data. Protein Quantification by Peptide Quality Control (PQPQ) of Shotgun Proteomics Data / Jenny Forshed -- Part III Methods Applied In Clinical Research. Collection and Handling of Blood Specimens for Peptidomics / Harald Tammen and Rudiger Hess -- An Automated RP-SCX Solid-Phase Extraction Procedure for Urinary Peptidomics Biomarker Discovery Studies / Crina I.A. Balog, Rico Derks, Oleg A. Mayboroda, and André M. Deelder -- Application of Phage Display for Ligand Peptidomics to Identify Peptide Ligands Binding to AQP2-Expressing Membrane Fractions / Byung-Heon Lee and Tae-Hwan Kwon -- Protein Expression Profiling of Brain Tumor Tissue Using SELDI-MS / Carl Wibom -- Comprehensive Analysis of MHC Ligands in Clinical Material by Immunoaffinity-Mass Spectrometry / Kie Kasuga.
- 2015 Kargereditors, N.D. Embleton, J. Katz, E.E. Ziegler.
- 2007 Springeredited by Luciano L'Abate.Low-cost interventions to promote physical and mental health / Luciano L'Abate -- Diets, health, and weight control : what do we know? / David L. Katz ... [et al.] -- Low-cost obesity interventions : the market for foods / Michael S. Finke and Sandra J. Huston -- Omega-3 polyunsaturated fatty acids and health / John C. Umhau and Karl M. Dauphinais -- Vitamins, minerals and health / Edward Giovannucci -- Herbal medicines in the treatment of psychiatric and neurological disorders / Shahin Akhondzadeh -- Daily practices for mindful exercise / Rachel Calogero and Kelly Pedrotty -- Relaxation and meditation / Angele McGrady -- Expressive movement / Dianne Dulicai and Ellen Schelly Hill -- Pleasant, pleasurable, and positive activities / Joan S. Anderson -- The recording of personal information as an intervention and as an electronic health support / Minna Levine and Ronald Calvanio -- Teaching to remember ourselves : the autobiographical methodology / Duccio Demetrio ; with contribution by Chiara Borgonovi -- Expressive writing : an alternative to traditional methods / Ewa Kacewicz, Richard B. Slatcher, and James W. Pennebaker -- Workbooks for the promotion of mental health and life-long learning / Luciano L'Abate and Damian Goldstein -- Computers and the Internet / Myron L. Pulier ... [et al.] -- Maternal-infant contact and child development : insights from the kangaroo intervention / Ruth Feldman -- Touch interventions positively affect development / Nancy Aaron James and Krystal D. Mize -- Non-erotic physical affection : it's good for you / Andrew K. Gulledge ... [et al.] -- Sex, sexuality and sensuality / Chad L. Cross and Gerald R. Weeks -- Intimacy and fear of intimacy / Anita L. Vangelisti and Gary Beck -- Low-cost interventions for promoting forgiveness / Lindsey M. Root and Michael E. McCullough -- Spirituality in achieving physical and psychological health and well-being : theory, research and low cost interventions / Len Sperry ... [et al.] -- Friendship, social support, and health / Patricia M. Sias and Heidi Bartoo -- Animal companions / Luciano L'Abate -- Applications of emotional intelligence to schools and workplace / David Ruback and Laura Sweeney -- Implications of prescriptive approaches for policy, health promotion, epidemiology, and public health / Cornelius Hogan.
- 2011Zuley Rivera Alvidrez.Any time we move, our brains solve the difficult problem of translating our motor intentions to muscle commands. Understanding how this computation takes place, and in particular, what role the motor cortex plays in movement generation, has been a central issue in systems neuroscience that remains unresolved. In this thesis, we took an unconventional approach to the analysis of cortical neural activity and its relationship to executed movements. We used dimensionality reduction to extract the salient patterns of neural population activity, and related those to the muscle activity patterns generated during arm reaches to a grid of targets. We found that salient neural activity patterns appeared to tightly reflect muscle activity patterns with a biologically-plausible lag. We also applied our analyses to movements that were planned before being executed, and found that a muscle-framework view of the cortical activity was consistent with previously-described predictions of movement kinematics based on the state of the cortical population activity. Overall, our results elucidate remarkable simplicity of the motor-cortical activity at the population level, despite the complexity and heterogeneity of individual cell's activities.
- 2014 SpringerBrendon J. Coventry, editor.Written by internationally acclaimed specialists, "Lower Abdominal and Perineal Surgery" provides pertinent and concise procedure descriptions spanning benign and malignant problems and minimally invasive procedures. Complications are reviewed when appropriate for the organ system and problem, creating a book that is both comprehensive and accessible. Stages of operative approaches with relevant technical considerations are outlined in an easily understandable manner. Forming part of the series, Surgery: Complications, Risks and Consequences, this volume Lower Abdominal and Perineal Surgery provides a valuable resource for all general surgeons and residents in training.
- 2005 Springeredited by Dennis G. Caralis and George L. Bakris.Claudication : clinical diagnosis and differential diagnosis / Dennis G. Caralis -- Noninvasive diagnostic evaluation of peripheral arterial disease / Nicholas Labropoulos and Apostolos K. Tassiopoulos -- Smoking and smoking cessation / Albert Bellg and Aristides N. Mavridis -- Peripheral arterial disease and diabetes / George L. Bakris -- Hyperlipidemia in peripheral arterial disease / Ambika Babu, C.R. Kannan, and Theodore Mazzone -- Hypertension and peripheral vascular disease / Anjula Gandhi, Jay Garg, and George L. Bakris -- Physical inactivity is a risk factor for lower extremity arterial disease and coronary heart disease / Dennis G. Caralis and Stamatis Dimitropoulos -- Pathogenesis of atheroslerotic vascular disease / Bassem Jamil Basha, George L. Bakris, and James R. Sowers -- Lower extremity arterial disease coexisting with coronary artery disease : management and prognosis / Dennis G. Caralis -- Medical therapy of claudication and lower extremity arterial disease / Dennis G. Caralis -- Exercise therapy for low extremity arterial disease / Peter F. Kokkinos -- Endovascular strategies for management of claudication and lower extremity arterial disease / Michael C. Brunner and Dennis G. Caralis -- Severe lower extremity arterial disease : limb salvage and revascularization failure / Chad E. Jacobs and Walter J. McCarthy.
- 2010 Springervolume editor, J. Schramm.Advances in imaging low-grade gliomas -- Molecular neuropathology of low-grade gliomas and its clinical impact -- What is the place of conservative management for adult supratentorial low-grade glioma? -- Seizures in patients with low-grade gliomas - incidence, pathogenesis, surgical management, and pharmacotherapy -- Present day's standards in microsurgery of low-grade gliomas -- Is there a place for radiotherapy in low-grade gliomas? -- The place of interstitial brachytherapy and radiosurgery for low-grade gliomas -- Health-related quality of life aspects in patients with low-grade glioma.
- 2011 OvidLowinson, Joyce H.; Ruiz, Pedro; Strain, Eric C."A comprehensive, authoritative text on all aspects of substance abuse and addiction medicine. Scientific topics such as the biology of various addictions and all dimensions of clinical treatment and management are addressed by a wide range of leading contributors. Behavioral addictions are addressed also, so the text is not solely devoted to specific substances and their misuse"--Provided by publisher.
- 2011Henrique do Carmo Miranda.Neural recording systems are fundamental to the advancement of brain-machine interfaces that can significantly improve the quality of lives of patients with neurological diseases, such as spinal cord injuries or quadriplegia. This thesis presents two newly developed wireless neural recording systems that are able to provide a high degree of usability and neural decoding accuracy. They are capable of simultaneously transmitting 32 to 96 channels of neural signals detected by an implanted neural sensor array. This work was carried out within the framework of the Hermes project and its technical design challenges will be addressed. The Hermes project is aimed at primarily developing hardware and software tools that extract neural information from the motor cortex. Those tools can enable practical prosthetic devices used to significantly ameliorate the life of patients with neurological impairments that directly affect motor functions. The first developed system, HermesD, is a 32-channel broadband transmission system using an FSK modulated carrier at 24 Mbit/s in the 3.7-4.1 GHz band. The link range extends beyond 20 m and the total power consumption is 142 mW. The HermesD system uses only COTS components and can be easily replicated. HermesD is fully operational and is currently used to transmit broadband neural data for neuroscience research in the Neural Prosthetic Systems Laboratory (NPSL) at Stanford University. HermesD is also planned as the base platform for future human trials to take place in the same laboratory. The second system that represents the next Hermes generation, HermesE, uses a novel UWB transmitter architecture implemented in a custom IC in the 65-nm CMOS technology. The transmitted signal bandwidth covers the 3.6 to 7.5 GHz frequency range. The time domain waveform is digitally programmable, allowing a very flexible control of the output spectrum to avoid interference and to allow multi-band operation. The UWB transmitter chip is part of a 96-channel broadband recording system delivering 40 Mbit/s. Its power consumption is 230 uW for a communication range of about 5 m. The antenna subsystems for these wireless recording devices presented a design challenge given the requirements for small size, large bandwidth and high efficiency. While HermesD has an operating FBW of 10%, HermesE is much more demanding in this respect, with 70% FBW, requiring unconventional antenna structures. The design techniques and performance of the antennas required to meet the specifications of both systems are also addressed in this work.
- John Krumboltz.
- 2008 SpringerElwood Carlson.
- 2016David B. Agus ; with Kristin Loberg.Destiny of the species : welcome to the lucky years -- The century of biology : the cure is already inside you -- This isn't science fiction : the power of technology to extend your life -- The future you : how your small data in the context of big data will save you -- The dawn of precision medicine : how to manage its power and perils -- Take the two-week challenge : how to measure and interpret your own data -- The danger of misinformation : how to know whom and what to trust -- A body in motion tends to stay lucky : the one supplement you're not getting enough of -- Wonder drugs that work : sleep, sex, touching, and tools to tame inflammation -- The butterfly effect : get ready to flap your wings.
- 2010 Thieme eNeurosurgeryeditors, Frank M. Phillips and Carl Lauryssen.Basic science -- Epidemiology and economics of intervertebral disc disease -- Anatomy and physiology of the lumbar intervertebral disc and endplates -- Biology of the lumbar intervertebral disc -- Biomechanics of the lumbar intervertebral disc -- Mechanisms of pain from intervertebral discs -- Biology and biomechanics of the spinal degenerative cascade -- Disc herniation -- Pathophysiology and etiology of intervertebral disc herniation -- Clinical features of herniated nucleus pulposus -- Nonsurgical treatment of herniated nucleus pulposus -- Percutaneous decompression -- Decompressive surgery for herniated nucleus pulposus (open, micro, and minimally invasive approaches) -- Annular repair and barrier technologies -- Degenerative disc disease -- Clinical presentation of disc degeneration -- Degenerative disc imaging -- Provocative testing (discography) -- Presurgical psychological screening -- Treatment of degenerative disc disease -- Mechanical diagnosis and therapy -- Role of education and back schools -- Cognitive therapy for symptomatic disc degeneration -- Biologic therapies for disc repair -- Intradiscal therapy -- Nucleus augmentation -- Interspinous devices -- Posterior nonfusion pedicle screw-based stabilization -- Lumbar spine arthroplasty -- Spinal fusion: posterior approaches -- Spinal fusion: anterior approach -- Spinal fusion: combined anteroposterior approach -- Minimally invasive spinal fusion procedures -- Biologics for spinal fusion -- Postoperative rehabilitation of lumbar spine patients -- Surgical treatment of degenerative lumbar disc disease: a critical review.
- Lumbar spinal imaging in radicular pain and related conditions : understanding diagnostic images in a clinical context2010 SpringerJan T. Wilmink.The Nature of Radicular Pain and Related Conditions -- Imaging Techniques for the Lumbar Spine: Conventional Radiology, Computed Tomography; Magnetic Resonance Imaging -- Normal Anatomy -- Pathologic Anatomy and Mechanisms of Nerve Root Compression -- Spinal Imaging in Relation to Surgical Therapy: Pre-and Post-Operative.
- 2006edited by Joseph P. Lynch III, David J. Ross.
- 2003 Springer Protocolsv. 2 Springer Protocolsedited by Barbara Driscoll.v. 1. Molecular pathology methods and reviews: Characteristic genetic alterations in lung cancer / Wistuba, II and A.F. Gazdar -- Clinical and biological relevance of recently defined categories of pulmonary neoplasia / E. Gabrielson -- Molecular epidemiology of human cancer risk. Gene-environment interactions and p53 mutation spectrum in human lung cancer / K. Vahakangas -- Neuroendocrine phenotype of small cell lung cancer / J.M. Coulson, M. Ocejo-Garcia and P.J. Woll -- Aids-associated pulmonary cancers / K. Katariya and R.J. Thurer-Abrogation of the rb-p16 tumor suppressor pathway in human lung cancer / J. Geradts -- Sensitive detection of hypermethylated p16ink4a alleles in exfoliative tissue material / M. Schuermann and M. Kersting -- Role of receptor tyrosine kinases in lung cancer / G. Maulik, T. Kijima and R. Salgia -- Relationship of egfr signal-transduction modulation by tyrosine kinase inhibitors to chemosensitivity and programmed cell death in lung cancer cell lines / W. Lei, P.P. Koty and M.L. Levitt -- Detection of the transcripts and proteins for the transforming growth factor-beta isoforms and receptors in mouse lung tumorigenesis using in situ hybridization and immunohistochemistry in paraffin-embedded tissue sections / S.B. Jakowlew and J. Mariano -- Alterations in the expression of insulin-like growth factors and their binding proteins in lung cancer / C.M. Coleman and A. Grimberg -- Screening of mutations in the ras family of oncogenes by polymerase chain reaction-based ligase chain reaction / A. Martinez [and others] -- Assays for raf-1 kinase phosphorylation and activity in human small cell lung cancer cells / R.K. Ravi and B.D. Nelkin -- Gamma-glutamylcysteine synthetase in lung cancer. Effect on cell viability / K. Jarvinen, Y. Soini and V.L. Kinnula -- Localization of cyclooxygenase-2 protein expression in lung cancer specimens by immunohistochemical analysis / S.A. Wardlaw and T.H. March -- Non-ri protocols for l-myc allelotyping and deletion mapping of chromosome 1p in primary lung cancers / K. Hiyama, C. Mendoza and E. Hiyama -- Intercellular adhesion molecules (icam-1, vcam-1, and lfa-1) in adenocarcinoma of lung. Technical aspects / A.E. Fraire [and others] -- Muc1 expression in lung cancer / E. Szabo -- Altered surface markers in lung cancer. Lack of cell-surface fas/apo-1 expression in pulmonary adenocarcinoma may allow escape from immune surveillance / Y. Nambu and D.G. Beer -- Prognostic relevance of angiogenic, proliferative, and apoptotic factors in lung carcinomas. A case review / M. Volm and R. Koomagi -- Morphological assessment of apoptosis in human lung cells / L.D. Dwyer-Nield [and others] -- [d-arg6, d-trp7,9, nmephe8]-substance p (6-11) activates jnk and induces apoptosis in small cell lung cancer cells via an oxidant-dependent mechanism / A. MacKinnon and T. Sethi -- Isolation of cells entering different programmed cell death pathways using a discontinuous percoll gradient / P.P. Koty [and others] -- Angiogenesis, metastasis, and lung cancer. An overview / A. Onn and R.S. Herbst -- Matrix metalloproteinase expression in lung cancer / M. Lim and D.M. Jablons -- Vascular endothelial growth factor expression in non-small cell lung cancer / K.J. O'Byrne [and others] -- Regulation of angiostatin mobilization by tumor-derived matrix metalloproteinase-2 / M.A. Moses and M.S. O'Reilly -- In vitro and in vivo assays for the proliferative and vascular permeabilization activities of vascular endothelial growth factor (vegf) and its receptor / S. Yano, R.S. Herbst and S. Sone -- Detection of telomerase activity in lung cancer tissues / K. Hiyama and E. Hiyama -- Analysis of alterations in a base-excision repair gene in lung cancer / N. Bhattacharyya and S. Banerjee -- Induction of lung cancer by passive smoking in an animal model system / H. Witschi -- Metastatic orthotopic mouse models of lung cancer / R.M. Hoffman -- Lung-specific expression of mutant p53 as mouse model for lung cancer / K.M. Tchou-Wong and W.N. Rom -- Use of nucleotide excision repair-deficient mice as a model for chemically induced lung cancer / D.L. Cheo and E.C. Friedberg -- Nude mouse lung metastases models of osteosarcoma and Ewing's sarcoma for evaluating new therapeutic strategies / S.F. Jia, R.R. Zhou and E.S. Kleinerman -- Tumor-specific metastasis to lung using reporter gene-tagged tumor cells / L.A. Culp [and others] -- Cultures of surgical material from lung cancers. A kinetic approach / B.C. Baguley, E.S. Marshall and T.I. Christmas -- The hollow fiber assay / L.A. Hall [and others]. v. 2. Diagnostic and therapeutic methods and reviews: Molecular and genetic aspects of lung cancer / W.N. Rom and K.M. Tchou-Wong -- Molecular alterations in lung cancer. Impact on prognosis / T. Kijima, G. Maulik and R. Salgia -- Cellular predictive factors of drug resistance in non-small cell lung carcinomas / M. Volm, R. Koomagi and W. Rittgen -- Clinical implications of p53 mutations in lung cancer / B.G. Campling and W.S. el-Deiry -- An epidemiologic and clinicopathologic overview of aids-associated pulmonary Kaposi's sarcoma / D.M. Aboulafia -- Myeloperoxidase promoter region polymorphism and lung cancer risk / X. Wu, M.B. Schabath and M.R. Spitz -- Clinical utility of tumor markers in the management of non-small cell lung cancer / D.E. Niewoehner and J.B. Rubins -- Detection of chromosomal aberrations in lung tissue and peripheral blood lymphocytes using interphase fluorescence in situ hybridization (fish) / R.A. el-Zein and S.Z. Abdel-Rahman -- In situ analysis of telomerase rna gene expression as a marker for tumor progression / W.N. Keith -- A high-throughput methodology for identifying molecular targets overexpressed in lung cancers / T. Wang and S.G. Reed -- Expression profiling of lung cancer based on suppression subtraction hybridization (ssh) / S. Petersen and I. Petersen -- Comparative genomic hybridization of human lung cancer / I. Petersen -- Sensitive assays for detection of lung cancer. Molecular markers in blood samples / M.V. Fournier [and others] -- Fluorescent microsatellite analysis in bronchial lavage as a potential diagnostic tool for lung cancer / J.K. Field and T. Liloglou -- Southern blotting of genomic DNA from lung and its tumors. Application to analysis of allele loss on chromosome 11p15.5 / D.M. Pitterle and G. Bepler -- Assessment of insulin-like growth factors and mutagen sensitivity as predictors of lung cancer risk / X. Wu [and others] -- Comparative multiplex pcr and allele-specific expression analysis in human lung cancer. Tools to facilitate target identification / J. Heighway [and others] -- Detection of k-ras point mutations in sputum from patients with adenocarcinoma of the lung by point-exacct / V.A. Somers and F.B. Thunnissen -- Detection of k-ras and p53 mutations by "mutant-enriched" pcr-rflp / M. Schuermann -- Detection of small cell lung cancer by rt-pcr for neuropeptides, neuropeptide receptors, or a splice variant of the neuron restrictive silencer factor / J.M. Coulson [and others] -- Utilization of thyroid transcription factor-1 immunostaining in the diagnosis of lung tumors / N.G. Ordonez -- Molecular biologic substaging of stage i nsclc through immunohistochemistry performed on formalin-fixed, paraffin-embedded tissue / M.B. Joshi, T.A. D'Amico and D.H. Harpole, Jr. -- A sensitive immunofluorescence assay for detection of p53 protein in the sputum / Z. Feng, D. Tian and R. Goldman -- Spr1. An early molecular marker for bronchial carcinogenesis / D. Lau [and others] -- Determination of biological parameters on fine-needle aspirates from non-small cell lung cancer / C. Bozzetti [and others] -- Detection and analysis of lung cancer cells from body fluids using a rare event imaging system / S.K. Kraeft, R. Salgia and L.B. Chen -- Reconstruction of geno-phenotypic evolutionary sequences from intracellular patterns of molecular abnormalities in human solid tumors / S.E. Shackney [and others] -- Surgical treatment of lung cancer. Past and present / C.F. Mountain and K.E. Hermes -- Recent advances and dilemmas in the radiotherapeutic management of locally advanced non-small cell lung cancer / B. Movsas -- Photodynamic therapy in lung cancer. A review / D. Ost -- Gene therapy for lung cancer. An introduction / E.B. Haura, E. Sotomayor and S.J. Antonia -- Identifying obstacles to viral gene therapy for lung cancer. Malignant pleural effusions as a paradigm / R.K. Batra, R.M. Bernal and S. Sharma -- Topical gene therapy for pulmonary diseases with pei-DNA aerosol complexes / A. Gautam [and others] -- Targeted delivery of expression plasmids to the lung via macroaggregated polyethylenimine-albumin conjugates / F.M. Orson [and others] -- Preparation of retroviral vectors for cell-cycle-targeted gene therapy of lung cancer / P.P. Claudio and A. Giordano -- Aerosol gene therapy for metastatic lung cancer using pei-p53 complexes / A. Gautam [and others] -- Clinical development of antisense oligonucleotides as anti-cancer therapeutics / H.X. Chen -- Antisense oligonucleotides targeting ri alpha subunit of protein kinase a. In vitro and in vivo anti-tumor activity and pharmacokinetics / R. Zhang and H. Wang -- Use of antisense oligonucleotides for therapy. Manipulation of apoptosis inhibitors for destruction of lung cancer cells / S.H. Leech, R.A. Olie and U. Zangemeister-Wittke -- Induction of programmed cell death with an antisense bcl-2 oligonucleotide / P.P. Koty, W. Lei and M.L. Levitt -- Tumor vaccination with cytokine-encapsulated microspheres / N.K. Egilmez [and others] -- Adoptive immunotherapy / J.A. Kim and S. Shu -- Intratumoral therapy with cytokine gene-modified dendritic cells in murine lung cancer models / S. Sharma [and others] -- Cyclooxygenase 2-dependent regulation of antitumor immunity in lung cancer / S. Sharma [and others] -- Chemoprevention of lung cancer / H. Witschi-Assessing the interaction of particulate delivery systems with lung surfactant / T.S. Wiedmann -- Chemopreventive therapeutics. Inhalation therapies for lung cancer and bronchial premalignancy / M. Haigentz, Jr. and R. Perez-Soler.
- 2010 Springeredited by David J. Stewart.
- 2005 Ovideditors, Harvey I. Pass, David, P. Carbone, David H. Johnson ... [et al.].Etiology and epidemiology -- Lung cancer biology -- Screening/early detection/prevention -- Pathology and molecular classification -- Clinical presentation, diagnosis, staging, and prognosis -- Surgery -- Radiation therapy -- Chemotherapy -- Multimodality therapy of NSCLC -- Treatment of small cell lung cancer -- Novel therapeutic strategies -- Palliation and special considerations -- Other thoracic tumors.
- 2012 Wileyedited by Alison Leary.Introduction to lung cancer and mesothelioma -- The presentation and diagnosis of lung cancer and mesothelioma -- Chemotherapy and biological agents -- Lung radiotherapy -- Surgery for lung cancer -- The nursing care of patients with lung cancer -- Supportive care in lung cancer -- End of life care -- Quality of life in lung cancer.
- 2015 SpringerMieczyslaw Pokorski, editor.Lung cancer and autoimmune diseases are complex entities in that they involve gene disturbance, gene polymorphism, and impaired gene repair mechanisms. The volume focuses on altered gene expression in tumor processes and in chronic autoimmune disorders. The chapters discuss the biological rationale for novel disease protein markers, present relevant clinical results, and give some diagnostic and therapeutic tips.Also available: Print – 2015
- 2016 SpringerAamir Ahmad, Shirish Gadgeel, editors.1. Lung Cancer Statistics -- 2. Epidemiology of Lung Cancer -- 3. Lung Cancer In Never Smokers -- 4. Immune Therapy -- 5. Anti-angiogenesis in personalized therapy of lung cancer -- 6. Target therapy in Lung Cancer -- 7. Mechanisms of Resistance to EGFR Tyrosine Kinase Inhibitors and Therapeutic Approaches: an update -- 8. KRAS-Mutant Lung Cancers in the Era of Targeted Therapy -- 9. Anaplastic Lymphoma Kinase (ALK) Signaling in Lung Cancer -- 10. Chemotherapy Resistance in Lung Cancer -- 11. Current state of metal-based drugs for the efficient therapy of lung cancers and lung metastases.
- 2016 SpringerAamir Ahmad, Shirish M. Gadgeel, editors.Lung cancer genomics in the era of accelerated targeted drug development / Priyanga Wijesinghe and Aliccia Bollig-Fischer -- Emerging biomarkers in personalized therapy of lung cancer / Philip T. Cagle, Kirtee Raparia, and Bryce P. Portier -- Epithelial mesenchymal transition in aggressive lung cancers / Vivek Mittal -- The role of cancer stem cells in recurrent and drug-resistant lung cancer / Raagini Suresh, Shadan Ali, Aamir Ahmad, Philip A. Philip -- The microenvironment of lung cancer and therapeutic implications / Vivek Mittal, Tina El Rayes, Navneet Narula, Timothy E. McGraw, Nasser K. Altorki, and Mary Helen Barcellos-Hoff -- Epigenetics in personalized management of lung cancer / Aamir Ahmad -- Next-generation sequencing and applications to the diagnosis and treatment of lung cancer / Kristina M. Kruglyak, Erick Lin, and Frank S. Ong -- Nanomedicine for treatment of lung cancer / Sajid Hussain -- Personalized therapy of small cell lung cancer / Bryan J. Schneider and Gregory P. Kalemkerian -- Personalized radiation therapy (PRT) for lung cancer / Jian-Yue Jin and Feng-Ming (Spring) Kong -- Personalized therapy of non-small cell lung cancers (NSCLC) / Shirish M. Gadgeel.
- 2014 Wileyedited by Jack A. Roth, Waun Ki Hong, Ritsuko Komaki ; associate editors: Anne S. Tsao, Joe Y. Chang, Shanda H. Blackmon.
- 2013 SpringerJames G. Ravenel, editor.While specialists often guide the care to lung cancer patients, it is often a general radiologist who is left to interpret studies that impact patient care and management. Lung Cancer Imaging provides a comprehensive guide to the diagnosis, staging and overview of the management of lung cancer relevant to practicing radiologists so that they can better understand the decision making issues and provide more directed and useful communication to the treating physicians. It Primary Care physicians will also find this book valuable to understand the relevant issues that they face when one of their.
- 2009 SpringerVenkateshwar Keshamouni, Douglas Arenberg, Gregory Kalemkerian, editors.Lung Cancer: Overview / Shirish M. Gadgeel and Gregory P. Kalemkerian -- Hallmarks of Metastasis / M. Roshni Ray and David M. Jablons -- Tumor Stem Cells and Metastasis / Jaclyn Y. Hung -- Epithelial-Mesenchymal Transition as a Mechanism of Metastasis / Katia Savary, Stefan Termén, Sylvie Thuault, Venkateshwar Keshamouni and Aristidis Moustakas -- Mechanisms of Tumor Cell Migration and Invasion in Lung Cancer Metastasis / Charles Kumar Thodeti and Kaustabh Ghosh -- Immunologic Mechanisms in Lung Carcinogenesis and Metastasis / Jay M. Lee, Jane Yanagawa, Saswati Hazra, Sherven Sharma and Tonya Walser, et al. -- Angiogenesis and Angiogenic Diversity in Lung Cancer Metastasis / Douglas A. Arenberg -- Chemokines in Lung Cancer Metastasis / Borna Mehrad, Ellen C. Keeley and Robert M. Strieter -- Molecular Control of Lymphatic Metastasis in Lung Cancer / Mark M. Fuster and Judith A. Varner -- Carcinoma-Associated Fibroblasts in Lung Cancer / Roya Navab, Bizhan Bandarchi and Ming-Sound Tsao -- The Role of Tumor-Associated Macrophages and Other Innate Immune Cells in Metastatic Progression of Lung Cancer / Zvi G. Fridlender, M. Cecilia Crisanti and Steven M. Albelda -- Experimental Animal Models for Studying Lung Cancer / Jiang Liu and Michael R. Johnston -- Molecular Imaging in Lung Cancer Metastases / Mahaveer Swaroop Bhojani, Shyam Nyati, Hyma R. Rao, Brian D. Ross and Alnawaz Rehemtulla -- Biomarker Discovery for Metastatic Disease / Gilbert S. Omenn and James D. Cavalcoli -- Current Clinical Management of Metastatic Lung Cancer / Bryan J. Schneider and Suresh S. Ramalingam -- Site-Directed Therapy for Lung Cancer Metastases / Kevin S Oh, Baskaran Sundaram, Venkataramu Krishnamurthy, Allan Pickens and Malini Venkatram, et al. -- Systems Approach for Understanding Metastasis / Peter J. Woolf, Angel Alvarez and Venkateshwar G. Keshamouni.
- 2008edited by Jack A. Roth, James D. Cox, Waun Ki Hong.Smoking cessation / Alexander V. Prokhorov, Kentya H. Ford, and Karen Suchanek Hudmon -- Lung cancer susceptibility genes / Joan E. Bailey-Wilson -- Lung cancer susceptibility and risk assessment models / Xifeng Wu ... [et al.] -- The molecular genetics of lung cancer / David S. Shames, Mitsuo Sato, and John D. Minna -- Molecular biology of preneoplastic lesions of the lung / Ignacio I. Wistuba and Adi F. Gazdar -- Detection of preneoplastic lesions / Stephen Lam -- Treatment of preneoplastic lesions of the lung / Annette McWilliams -- The pathology and pathogenesis of peripheral lung adenocarcinoma including bronchioloalveolar carcinoma / Wilbur A. Franklin -- Treatment of bronchioloalveolar carcinoma / Ji-Youn Han, Dae Ho Lee, and Jin Soo Lee -- Molecular profiling for early detection and prediction of response in lung cancer / Jacob M. Kaufman and David P. Carbone -- The role for mediastinoscopy in the staging of nonsmall cell lung cancer / Carolyn E. R̈eed -- Minimally invasive surgery for lung cancer / Michael Kent, Miguel Alvelo-Rivera, and James Luketich -- Extended resection for lung cancer / Philippe G. Dartevelle, Bedrettin Yildizeli, and Sacha Mussot -- Adjuvant chemotherapy following surgery for lung cancer / Benjamin Besse and Thierry Le Chevalier -- Induction chemotherapy for resectable lung cancer / Katherine M.W. Pisters -- Image-guided radiation therapy / Kenneth E. Rosenzweig and Sonal Sura -- Stereotactic body radiation therapy for lung cancer / Robert D. Timmerman and Brian D. Kavanagh -- Proton therapy / Joe Y. Chang, Alfred R. Smith, and James D. Cox -- Combinations of radiation therapy and chemotherapy for nonsmall cell lung carcinoma / Zhongxing Liao, Frank V. Fossella, and Ritsuko Komaki -- New chemotherapeutic agents in lung cancer / Anne S. Tsao -- Immunologic approaches to lung cancer therapy / Jay M. Lee, Steven M. Dubinett, and Sherven Sharma -- Epidermal growth factor receptor inhibitors / Lecia V. Sequist and Thomas J. Lynch -- Tumor angiogenesis: biology and therapeutic implications for lung cancer / Emer O. Hanrahan, Monique Nilsson, and John V. Heymach -- Retinoids and rexinoids in lung cancer prevention and treatment / Nishin Bhadkamkar and Fadlo R. Khuri -- Proteasome inhibition in nonsmall cell lung cancer therapy / Minh Huynh and Primo N. Lara Jr. -- Targeted genetic therapy for lung cancer / Jack Roth -- Screening for early detection / James L. Mulshine -- Natural agents for chemoprevention of lung cancer / Amir Sharafkhaneh ... [et al.].
- 2016 SpringerKaren L. Reckamp, editor.Lung cancer screening -- Diagnosis and molecular classification of lung cancer -- Lung cancer staging and prognosis -- Surgical treatment of lung cancer -- Treatment: radiation therapy -- Chemotherapy for advanced non-small cell lung cancer -- Multimodality therapy for NSCLC -- Targeted therapies for lung cancer -- Resistance to therapy -- Immunotherapy in lung cancer -- Palliative care in lung cancer -- Management of lung cancer in the elderly -- Multidisciplinary care -- Small cell lung cancer.
- 2006J.E. Cotes, D.J. Chinn, M.R. Miller.Distribution and measurement of pulmonary blood flow -- Inter-relations between lung ventilation and perfusion -- Transfer of gases into blood in alveolar capillaries -- Transfer factor (diffusing capacity) for carbon monoxide and nitric oxide (Tl,co, Tl,no, Dm and Vc) -- The oxygenation of blood -- Gas exchange for carbon dioxide and acid-base balance -- Control of respiration -- Newborn babies, infants and young children (ages 0-6 years) -- Normal lung function from childhood to old age -- Reference values for lung function in white (caucasian) children and adults -- Genetic diversity : reference values in non-caucasians -- Physiology of exercise and changes resulting from lung disease -- Exercise testing and interpretation, including reference values -- Assessment of exercise limitation, disability and residual ability -- Exercise in children -- Early developments and future prospects -- Getting started -- Development and functional anatomy of the respiratory system -- Body size and anthropometric measurements -- Numerical interpretation of physiological variables -- Basic terminology and gas laws -- Basic equipment and measurement techniques -- Respiratory surveys -- Thoracic cage and respiratory muscles -- Lung volumes -- Lung and chest wall elasticity -- Forced ventilatory volumes and flows (ventilatory capacity) -- Determinants of maximal flows (flow limitation) -- Theory and measurement of respiratory resistance (including whole body plethysmography) -- Control of airway calibre and assessment of changes -- Distribution of ventilation -- Investigation and physiology of breathing during sleep -- Assessment and treatment of sleep related breathing disorders -- Hypobaria : high altitude and aviation physiology and medicine -- Immersion in water, hyperbaria and hyperoxia including O2 therapy -- Cold, heat and the lungs -- Airborne respiratory hazards : features, protective mechanisms and consequences -- Patterns of abnormal function in lung disease -- Strategies for assessment -- Lung function in asthman, COPD, emphysema and diffuse lung fibrosis -- How individual diseases affect lung function (compendium) -- Lung function in relation to general anaesthesia and artificial ventilation -- Lung function in relation to surgery -- Pulmonary rehabilitation.
- 2012 CRCnetBASEedited by Ayman El-Baz, Jasjit S. Suri."Lung cancer remains the leading cause of cancer-related deaths worldwide. Early diagnosis can improve the effectiveness of treatment and increase a patient's chances of survival. Thus, there is an urgent need for new technology to diagnose small, malignant lung nodules early as well as large nodules located away from large diameter airways because the current technology, namely, needle biopsy and bronchoscopy, fail to diagnose those cases. However, the analysis of small, indeterminate lung masses is fraught with many technical difficulties. Often patients must be followed for years with serial CT scans in order to establish a diagnosis, but inter-scan variability, slice selection artifacts, differences in degree of inspiration, and scan angles can make comparing serial scans unreliable. Lung Imaging and Computer Aided Diagnosis brings together researchers in pulmonary image analysis to present state-of-the-art image processing techniques for detecting and diagnosing lung cancer at an early stage. The book addresses variables and discrepancies in scans and proposes ways of evaluating small lung masses more consistently to allow for more accurate measurement of growth rates and analysis of shape and appearance of the detected lung nodules. Dealing with all aspects of image analysis of the data, this book examines: Lung segmentation, Nodule segmentation, Vessels segmentation, Airways segmentation, Lung registration, Detection of lung nodules, Diagnosis of detected lung nodules, Shape and appearance analysis of lung nodules. Contributors also explore the effective use of these methodologies for diagnosis and therapy in clinical applications. Arguably the first book of its kind to address and evaluate image-based diagnostic approaches for the early diagnosis of lung cancer, Lung Imaging and Computer Aided Diagnosis constitutes a valuable resource for biomedical engineers, researchers, and clinicians in lung disease imaging"--Provided by publisher.
- 2005 Springerby Stuart Houser, Ulysses J. Balis, Eugene J. Mark.Non-neoplastic disease -- Airway disease -- Alveolar disease -- Interstitial lung disease -- Histological patterns consistent with pulmonary infectious disease -- Granulomatosis -- Pulmonary vascular disease -- Miscellaneous pulmonary disease -- Non-neoplastic pleural disease -- Neoplastic pulmonary and pleural disease -- Lung tumors -- Pleural tumors.
- 2009Leontios J. Hadjileontiadis.The nature of lung sound signals -- Historical overview -- Main characteristics and categorization -- Recording issues -- Standards -- Procedures and considerations -- Trends in LS analysis -- New domains in LS representation -- Overview -- Higher-order statistics (spectra) -- Epitomized rationale -- HOS definitions: higher-order statistics -- HOS definitions: higher-order spectra -- The parametric approach -- LS quadratic phase coupling detection -- Autoregressive-HOS modeling of LS source and transmission -- Lower-order statistics -- Epitomized rationale -- LOS definitions: a-stable distribution -- LOS definitions: fractional lower-order moments and covariation coefficient -- LOS analysis tools: converging variance test -- LOS analysis tools: parameter estimates for SAS distributions -- LOS analysis tools: AR modeling of SAS distributions -- LOS analysis of discontinuous adventitious sounds -- Wavelet analysis -- Epitomized rationale -- Continuous wavelet transform -- Discrete WT and multiresolution representation -- Wavelet-based analysis of LS -- Wavelet-HOS -- Epitomized rationale -- CWT-HOS definitions -- Wheeze analysis with CWT-HOS -- Higher-order crossings -- Epitomized rationale -- HOC definitions -- HOC discrimination tools -- HOC analysis of DAS -- Empirical mode decomposition -- Epitomized rationale -- EMD description -- EMD considerations and extensions -- EMD crackles analysis -- Fractal dimension-lacunarity analysis -- Epitomized rationale -- FD estimation -- Lacunarity estimation -- FD analysis of LS -- Lacunarity analysis of DAS -- Denoising techniques -- Overview -- Wavelet-based denoising -- CWT-WED -- WTST-NST filter -- Kurtosis-based extractor -- Fractal dimension-based detector -- Wavelet-fractal dimension-based denoising -- Empirical mode decomposition-fractal dimension-based denoising -- Heart sound cancellation -- HOS-based HSC -- WT-based HSC -- Recursive least squares-based HSC -- Time-frequency-based HSC -- Recurrent time statistics and nonlinear prediction-based HSC -- Other denoising approaches -- Fuzzy logic-based denoising -- Independent component analysis-based HSC -- Variance fractal dimension-based heart sound localization -- Entropy-based heart sound localization -- Reflective implications -- From an engineer's viewpoint -- From a physician's viewpoint.
- 2016 SpringerDaniel A. Lichtenstein.The tools of the BLUE-protocol: Basic notions: the indispensable -- Which unit -- Which probe -- Specific notions -- The seven principles of L.U.C.I. -- The BLUE-points -- The 10 signatures at a glance -- The pleural line -- The A-profile and the A-line -- The A-profile and lung sliding -- The B-line -- Interstitial syndrome and lung rockets -- The B-profile, the B'-profile -- The A'-profile and pneumothorax -- PLAPS -- PLAPS and pleural effusion -- PLAPS and lung consolidation. The C-profile -- BLUE-DVT. Deep venous thrombosis in the BLUE-protocol -- Simple emergency cardiac sonography -- The BLUE-protocol in clinical use: Basic principle of the BLUE-protocol. The 8 profiles. The data -- Excluded patients of the BLUE-protocol -- Frequently asked questions on the BLUE-protocol -- The BLUE-protocol and pneumonia.- The BLUE-protocol and acute hemodynamic pulmonary edema -- The BLUE-protocol, asthma and COPD -- The BLUE-protocol and pulmonary embolism.- The BLUE-protocol and pneumothorax.- The main products derived from the BLUE-protocol: Pink-protocol (lung ultrasound in ARDS) -- The LUCI-FLR project (decrease of medical irradiation) -- FALLS-protocol (heart, lung, venous ultrasound in management of acute circulatory failure).- SESAME-protocol (ultrasound in cardiac arrest).- Extension of lung ultrasound to specific disciplines, wider settings, various considerations: Lung ultrasound in the neonate.- All specialties involved in lung ultrasound.- Critical ultrasound, lung, heart and DVT apart.- The Extended BLUE-protocol.- Non critical ultrasound.- Various considerations.- How to learn the BLUE-protocol.- Holistic ultrasound, a new definition -- how it can impact critical medicine.- Lung artifacts from A to Z.
- 2015 SpringerRaymond Chuen-Chung Chang, Kwok-Fai So, editors.1. Chemical and genetic diversity of Wolfberry -- 2. Immunoregulation and Lycium Barbarum -- 3. The antioxidant, anti-inflammatory, and antiapoptotic effects of Wolfberry in fatty liver disease -- 4. Effectts of Lycium barbarum on modulation of blood vessel and hemodynamics -- 5. Dermatologic uses and effects of Lycium barbarum -- 6. Lycium Barbarum and tumors in the gastrointestinal tract -- 7. Prevention of neurodegeneration for Alzheimer's disease by Lycium barbarum -- 8. Prosexual effects of Lycium Barbarum -- 9. Lycium Barbarum: neuroprotective effects in ischemic stroke -- 10. Secondary degeneration after partial optic nerve injury and possible neuroprotective effects of Lycium Barbarum (Wolfberry) -- 11. Role of Lycium Barbarum extracts in retinal diseases -- 12. Allergenic sensitisation mediated by Wolfberry.
- 2009 Kargervolume editors, Dan Lipsker, Benoît Jaulhac .Borrelia burgdorferi sensu lato diversity and its influence on pathogenicity in humans / Baranton, G., De Martino, S.J -- Life cycle of Borrelia burgdorferi sensu lato and transmission to humans / Gern, L. -- Epidemiology of Lyme borreliosis / Hubálek, Z. -- Clinical manifestations and diagnosis of Lyme borreliosis / Strle, F., Stanek, G. -- Treatment and prevention of lyme disease / Hansmann, Y. -- Other tick-borne diseases in Europe / Bitam, I., Raoult, D. -- What should one do in a case of a tick bite? / Aberer, E. -- When to order a Western blot and how to interpret it / Hunfeld, K. P., Kraiczy, P. -- Is serological follow-up useful for patients with cutaneous Lyme borreliosis? -- Müllegger, R.R., Glatz, M. -- How do I manage tick bites and Lyme borreliosis in pregnant women? / Maraspin, V., Strle, F. -- What should be done in case of persistent symptoms after adequate antibiotic treatment for lyme disease? / Puchal, X., Sibilia, J. -- What are the indications for lumbar puncture in patients with lyme disease? / Rupprecht, T. A., Pfister, H.-W.Also available: Print – 2009
- 2011 SpringerStefan E. Pambuccian, Ricardo H. Bardales.Introduction -- Overview of ancillary methods in lymph node FNA diagnosis -- Lymphadenopathy: anatomic and clinical clues to fine needle aspiration diagnosis -- Cytology of normal/reactive lymph nodes -- Overall assessment of the aspirate: diagnostic clues -- Overview of the algorithmic pattern-based approach to lymph node FNA -- The polymorphous lymphoid cell pattern -- The monotonous small-cell pattern -- The monotonous intermediate-sized cell pattern -- The monotonous large cell pattern -- The pleomorphic cell pattern -- Infectious and noninfectious lympadenitis -- Unusual neoplastic and nonneoplastic conditions of lymph nodes -- Pitfalls and limitations of FNA of lymph nodes.
- 2008Lawrence M. Weiss.Specimens and studies -- Normal lymph node -- Benign lymphadenopathies -- Epithelial and nevomelanocytic lesions of lymph nodes -- Stromal tumors and tumorlike lesions of lymph nodes -- Hodgkin lymphoma -- Non-Hodgkin lymphoma -- Composite lymphomas and interface between classical Hodgkin and non-Hodgkin lymphoma -- Immunodeficiency-associated lymphoproliferative disorders -- Histiocytic and dendritic cell neoplasms -- Myeloid and mast cell neoplasms.
- 2009 Springeredited by Steven A. Stacker and Marc G. Achen.
- 2008 SpringerLawrence Tretbar ... [et al.].
- 2011 SpringerByung-Boong Lee, John Bergan, Stanley G. Rockson, editors.Primary Lymphedema as a Truncular Lymphatic Malformation -- Primary Lymphedema and Klippel-Trénaunay Syndrome -- Special Issues in Pediatric Primary Lymphedema -- Medical Management -- Surgical Management -- Epidemiology -- Etiology and Pathophysiology -- Clinical Overview-Diagnosis and Management -- Genetic Prospects for Lymphedema Management -- Breast Cancer -- Lower Extremity Cancers -- Radiation Complications -- Pathophysiology of Phlebolymphedema and a Physiologic Approach to Chronic Veno-lymphatic Insufficiency' -- Diagnosis and Management of Primary Phlebolymphedema -- Diagnosis and Management of Secondary Phlebolymphedema -- Management of Phlebolymphedema Ulcers -- Lymphedema Management by the Therapists -- Education of the Patient -- Patient/Family Advocacy -- Reimbursement of CDT-based Care -- General Considerations -- Etiology and Classification of Lymphatic Disorders -- Hereditary and Familial Lymphedema -- Embryology of the Lymphatic System and Lymphangiogenesis -- Anatomy of the Lymphatic System and Its Disorders -- Physiology, Pathophysiology, and Lymphodynamics: General Overview -- Lymphedema -- Physiology, Biology, and Lymph Biochemistry -- Physiology - Lymph Flow -- Pathology and Histochemistry -- Clinical Diagnosis: General Overview -- Clinical Staging -- Combined Clinical and Laboratory (Lymphoscintigraphic) Staging -- Early Diagnosis in Latent Phase -- Review of National and International Consensuses on Chronic Lymphedema -- Differential Diagnosis - General Considerations -- Differential Diagnosis - Lipedema -- Laboratory/Imaging Diagnosis: General Guidelines -- Radionuclide Lymphoscintigraphy -- Duplex Ultrasonography -- Combined Role of Lymphoscintigraphy, X-Ray Computed Tomography, Magnetic Resonance Imaging, and Positron Emission Tomography in the Management of Lymphedematous Disease -- Oil Contrast Lymphangiography -- Fluorescent Microlymphangiography -- Alternative Assessment and Measurement Tools -- Infection -- Physiological Principles of Physiotherapy -- Complete Decongestive Therapy -- Manual Lymph Drainage (Földi Method) -- Manual Lymph Drainage (Leduc Method) -- Compression Therapy -- Intermittent Pneumatic Compression Therapy -- Other Contemporary Treatment Modalities -- Medical Treatment -- Lower Limb Lymphedema -- Upper Limb Lymphedema -- Head and Neck Lymphedema -- Genital Lymphedema -- Psychological Aspect: Compliance and Quality of Life -- General Overview - Historical Background -- General Principles and Indications -- Lymphatic-Venous Derivative and Reconstructive Microsurgery -- Lymphatic-Lymphatic Reconstructive Microsurgery -- Lymph Node-Venous Microvascular Reconstructive Surgery: Filariasis Lymphedema -- Lymph Nodes Transfer Microvascular Reconstructive Surgery -- Current Dilemmas and Controversy -- Prospects for Lymphatic Reconstructive Surgery -- Historical Background - General Overview -- General Principles -- Contemporary Indications and Controversies -- Surgical Treatment of Postmastectomy Lymphedema - Liposuction -- Epilogue.
- 2015 SpringerArin K. Greene, Sumner A. Slavin, Håkan Brorson, editors.This volume is a clinically-oriented book that can be used for patient care, teaching, or research. It covers the entire field of lymphedema, including both primary and secondary disease, as well as all diagnostic and treatment modalities. The text begins with a foundation for the condition, including its pathophysiology, epidemiology, and morbidity. Next, the classification of lymphedema is covered which is the template for accurate diagnosis. Clinical, radiological, and differential diagnosis of lymphedema is also reviewed. Finally, conservative and operative management is presented, including both physiologic and excisional procedures. Lymphedema: Presentation, Diagnosis, and Treatment provides a comprehensive, easy-to-read reference for any health care provider managing a patient with lymphedema. The text is clinically-focused, evidence-based, and practical. The reader, regardless of his/her level of training or specialty, will be able to adequately treat a patient with lymphedema using this resource. To facilitate its use in clinical settings, the book was designed to be portable. In addition, diagnostic and treatment algorithms are included to further simplify the management of these patients. Patient images are presented throughout the text to illustrate the clinical care of lymphedema. All chapters are written by experts in the field, and contain the most current information on the topic.
- 2006 Springeredited by Constantine Tsoukas.Protein kinase C-theta (PKC[theta]): new perspectives on its functions in T-cell biology / Rina Barouch-Bentov and Amnon Altman -- Travel informations on the tec kinases during lymphocyte activation / Fabien Garçon and Jacques A. Nunès -- Inducible T-cell tyrosine kinase (ITK): structural requirements and actin polymerization / Constantine D. Tsoukas ... [et al.] -- Differential requirements of PI3K subunits for BCR or BCR/CD19-induced ERK activation / Elena Vigorito and Martin Turner -- Protein tyrosine phosphatases in human disease / Tomas Mustelin -- The T-cell-specific adapter protein functions as a regulator of peripheral but not central immunological tolerance / Philip E. Lapinski ... [et al.] -- Proximal signals controlling B-cell antigen receptor (BCR) mediated NF-[kappa]B activation / Miguel E. Moreno-García ... [et al.] -- The adapter 3BP2: how it plugs into leukocyte signaling / Marcel Deckert and Robert Rottapel -- CTLA-4 regulation of T-cell function via RAP-1-mediated adhesion / Helga Schneider ... [et al.] -- Protein crosstalk in lipid rafts / Raquel J. Nunes, Mónica A.A. Castro, and Alexandre M. Carmo -- Role of lipid rafts in activation-induced cell death: the fas pathway in aging / Anis Larbi ... [et al.] -- T-cell response in aging: influence of cellular cholesterol modulation / Tamàs Fülöp ... [et al.] -- Lymphocyte signaling and the translatability of mRNA / Suzanne Miyamoto -- Protein arginine methylation: a new frontier in T-cell signal transduction / Brandon T. Schurter, Fabien Blanchet, and Oreste Acuto -- Immune regulation by ubiquitin conjugation / K. Venuprasad ... [et al.] -- CTIB (C-terminus protein of I[kappa]B-[beta]): a novel factor required for acidic adaptation /Toshiko Fukamachi ... [et al.] -- HIV may deplete most CD4 lymphocytes by a mechanism involving signaling through its receptors on non-permissive resting lymphocytes / Miles W. Cloyd ... [et al.] -- Integrating traditional and postgenomic approaches to investigate lymphocyte development and function / Yina Hsing Huang ... [et al.] -- Phosphoproteomic analysis of lymphocyte signaling / Lulu Cao, Kebing Yu, and Arthur R. Salomon.Also available: Print – 2006
- 2006 SpringerRaffaele Badolato, Silvano Sozzani, editors.Also available: Print – 2006
- 2007Estella Matutes, Barbara J. Bain, Andrew Wotherspoon.
- 2013 SpringerAnas Younes, Bertrand Coiffier, editors.Recently, understanding the molecular pathogenesis of malignant lymphomas has led to improvement in the diagnostic precision and to the identification of a variety of molecular therapeutic targets. In addition, new drugs have been approved in the US and Europe, resulting in changes in the standard of care of several types of lymphoid malignancies. Comprehensive in scope and developed by a team of internationally renowned authors, Lymphoma: Diagnosis and Treatment provides a timely update on the most important advances in the biology, diagnosis, and therapy of lymphomas. As part of the Current Clinical Oncology series, Lymphoma: Diagnosis and Treatment will be of value to medical oncologists, hematologists, radiation oncologists, and all physicians involved in the care of patients with lymphoid malignancies.
- 2005 Springer Protocolsedited by Tim Illidge, Peter W.M. Johnson.
- 2012 SpringerTracy Batchelor, Lisa M. DeAngelis, editors ; foreword by James O. Armitage and Franco Cavalli.Pt. 1. Introduction -- pt. 2. Central nervous system lymphomas -- pt. 3. Primary CNS lymphoma -- pt. 4. Variants of CNS lymphoma -- pt. 5. Neurological complications of lymphomas and leukemias -- pt. 6. Neurological complications of therapy for lymphomas and leukemias.
- 2013 Springer Protocolsedited by Ralf Küppers.Origin and pathogenesis of B cell lymphomas / Marc Seifert, René Scholtysik, and Ralf Küppers -- Flow cytometry for non-Hodgkin and classical Hodgkin lymphoma / David Wu, Brent L. Wood, and Jonathan R. Fromm -- Laser-based microdissection of single cells from tissue sections and PCR analysis of rearranged immunoglobulin genes from isolated normal and malignant human B cells / Ralf Küppers, Markus Schneider, and Martin-Leo Hansmann -- PCR-based analysis of rearranged immunoglobulin or T-cell receptor genes by genescan analysis or heteroduplex analysis for clonality assessment in lymphoma diagnostics / Elke Boone, Brenda Verhaaf, and Anton W. Langerak -- Expression cloning of human B cell immunoglobulins / Hedda Wardemann and Juliane Kofer -- Studying the replication history of human B lymphocytes by real-time quantitative (RQ)-PCR / Menno C. van Zelm, Magdalena A. Berkowska, and Jacques J.M. van Dongen -- Detection of chromosomal translocations involving the immunoglobulin loci in B-cell malignancies / Martin J.S. Dyer -- Stereotyped B cell receptors in B cell leukemias and lymphomas / Nikos Darzentas and Kostas Stamatopoulos -- Flow cytometric MRD detection in selected mature B-cell malignancies / Sebastian Böttcher, Matthias Ritgen, and Michael Kneba -- MRD Detection in B-cell non-hodgkin lymphomas using Ig gene rearrangements and chromosomal translocations as targets for real-time quantitative PCR / Christiane Pott [and others] -- Enrichment of methylated DNA by methyl-CpG immunoprecipitation / Miriam Sonnet [and others] -- Gene expression profile analysis of lymphomas / Katia Basso and Ulf Klein -- FISH and FICTION to detect chromosomal aberrations in lymphomas / Maciej Giefing and Reiner Siebert -- Identification of pathogenetically relevant genes in lymphomagenesis by shRNA library screens / Vu N. Ngo -- Studying microRNAs in lymphoma / Joost Kluiver, Izabella Slezak-Prochazka, and Anke van den Berg -- Molecular methods of virus detection in lymphoma / Ruth F. Jarrett, Alice Gallagher, and Derek Gatherer -- High-throughput RNA sequencing in B-cell lymphomas / Wenming Xiao [and others].
- 2014 Cambridgeedited by Robert Marcus, John W. Sweetenham, Michael E. Williams.Epidemiology / Eve Roman and Alexandra G. Smith -- Prognostic factors for lymphomas / Guillaume Cartron and Philippe Solal-Celigny -- Imaging / Heok K. Cheow and Ashley S. Shaw -- Clinical trials in lymphoma / Thomas M. Habermann and Matthew Maurer -- Hodgkin lymphoma / Stephanie Sasse and Andreas Engert -- Follicular lymphoma / Kristian Bowles, Daniel Hodson, and Robert Marcus -- MALT and other marginal zone lymphomas / Emanuele Zucca and Francesco Bertoni -- Small lymphocytic lymphoma/chronic lymphocytic leukemia / Peter Hillmen -- Waldenstrom's macroglobulinemia/lymphoplasmacytic lymphoma / Steven P. Treon and Giampaolo Merlini -- Mantle cell lymphoma / Martin Dreyling and Michael E. Williams -- Burkitt and lymphoblastic lymphoma : clinical therapy and outcome / Nirali N. Shah, Alan S. Wayne, and Wyndham H. Wilson -- Therapy of diffuse large B-cell lymphoma / John W. Sweetenham -- Central nervous system lymphomas / Andres J.M. Ferreri and Lisa M. DeAngelis -- T-cell non-Hodgkin lymphoma / Sheetal M. Kircher [and others] -- Primary cutaneous lymphoma / Sean Whittaker -- Lymphoma in the immunosuppressed / Michele Spina [and others] -- Atypical lymphoproliferative, histiocytic, and dentritic cell disorders / Matthew S. Davids and Jennifer R. Brown.
- 2007edited by Robert Marcus, John W. Sweetenham, Michael E. Williams.
- 2006editors, George P. Canellos, T. Andrew Lister, Bryan D. Young.
- v. 1-2, 1976senior author, Stanley S. Raphael ; authors, Charles F. A. Culling ... [et al.].
- François Iselin.Discusses medical practitice at the Court at Versailles and the physicians and their royal patrons from 1682 to 1789.
- 2007 Springer[edited by] John A. Barranger, Mario A. Cabrera-Salazar.
- 2005 SpringerPaul Saftig.History and morphology of the lysosome / Renate Lüllmann-Rauch -- Transport of lysosomal enzymes / Stephan Storch and Thomas Braulke -- Adaptor proteins in lysosomal biogenesis / Peter Schu -- Lysosomal membrane proteins / Paul Saftig -- Lysosomal proteases: revival of the sleeping beauty / Klaudia Brix -- Lysosomal storage disorders / Ole Kristian Greiner-Tollersrud and Thomas Berg -- Lysosomal transporters and associated diseases / Frans W. Verheijen and Grazia M.S. Mancini -- Neuronal ceroid-lipofuscinoses / Jaana Tyynelè -- Cholesterol transport in lysosomes / Judith Storch and Sunita R. Cheruku -- Therapy of lysosomal storage diseases / Ulrich Matzner -- Lysosomal proteome and transcriptome / Jobst Landgrebe and Torben Lubke -- External lysosomes: the osteoclast and its unique capacities / Vincent Everts and Wouter Beertsen -- Membrane resealing mediated by lysosomal exocytosis / Norma W. Andrews -- Macroautophagy in mammalian cells / Eeva-Liisa Eskelinen -- Chaperone-mediated autophagy / Erwin Knecht and Natalia Salvador.
- 2015 ScienceDirectedited by Frances Platt, Nick Platt.
- Laboratory and diagnostic tests with nursing implications. 8th ed. — Lead optimization for medicinal chemists : pharmacokinetic properties of functional groups and organic compounds (118)
- Leadership in healthcare — LGBT psychology : research perspectives and people of African descent (118)
- Lgr5+ intestinal stem cells and their maintenance — Liver disease in children. 3rd ed. (118)
- Liver immunology : principles and practice. Second edition. [2nd ed.] — Lysosomes and lysosomal diseases (117)
- Harrison's Principles of Internal Medicine
- AAP Red Book Online
- Robbins & Cotran Pathologic Basis of Disease
- Sabiston Textbook of Surgery
- Nelson's Textbook of Pediatrics
- Surgical Exposures in Orthopaedics
- Mandell, Douglas, & Bennett's Principles & Practice of Infectious Diseases
- Red Book Online
- ICU Book
- Primary Care Medicine
- Campbell-Walsh Urology
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