Lane Medical Library

Passing on the Stead legacy / Andrew G. Wallace -- The patient is the focus of doctoring / Francis A. Neelon -- Learning is a community affair / E. Harvey Estes -- We learn most when we ourselves teach / Earl N. Metz -- Thinking trumps memorization : the lesson on attending rounds? / Joseph C. Greenfield, Jr. -- Brain sorting in the 21st century / Galen S. Wagner -- Teachers of medicine and their students / Harold R. Silberman -- Summing up the symposium / Francis A. Neelon, E. Harvey Estes, Andrew G. Wallace.

Visual Basic.NET and .NET programming --Getting started with VB.NET --Object-oriented programming --Visual studio .NET --VB.NET language fundamentals --Branching --Operators --Classes and objects --Inside methods --Basic debugging --Inheritance and polymorphism --Structures --Interfaces --Arrays --Collection interfaces and types --Strings --Throwing and catching exceptions -Applications and events --Afterword.

The world grows old -- Health and social services care for elderly people in the United Kingdom -- Special features of medicine in the elderly -- Old age psychiatry -- Falls and immobility -- Bones, joints and muscles -- Stroke made simple -- Other diseases of the nervous system -- Cardiovascular disorders -- Respiratory disease -- Gastrointestinal disease and nutrition -- Disorders of homeostasis and metabolism -- Genitourinary disease -- Blood and bone marrow -- Eyes, ears and skin -- Legal and ethical aspects -- Palliative care.

Normal haemoglobin, blood cells, and haemopoiesis -- Anaemia and polycythaemia : general considerations -- Haemolytic anaemias -- Iron metabolism, iron-deficiency anaemia and other hypochromic microcytic anaemias -- Macrocytosis and macrocytic anaemia -- Conditions causing white cell abnormalities -- Structure and function of lymphoid tissue -- Lymphomas - general principles -- Classification of lymphoma -- Hodgkin's lymphoma and some of the commoner clinical entities of non-Hodgkin's lymphomas including acute lymphoblastic leukaemia and chronic lymphocytic leukaemia -- Myeloma and other paraproteinaemias -- Neoplastic disorders of myeloid cells -- Bone marrow transplantation -- Aplastic anaemia and pure red cell aplasia -- Blood transfusion and haemolytic disease of the newborn -- Haemostasis, abnormal bleeding and anticoagulant therapy.

General topics -- System-based infections -- Multisystem infections -- Infection in special groups, zoonoses, tropical diseases and helminths.

Anatomy and physiology of the lungs -- Symptoms and signs of respiratory disease -- Pulmonary function tests -- Radiology of the chest -- Upper respiratory tract infections -- Pneumonia -- Tuberculosis -- Respiratory disease in AIDS and immunocompromised patients -- Bronchiectasis and lung abscess -- Cystic fibrosis -- Asthma -- Chronic obstructive pulmonary disease -- Carcinoma of the lung -- Interstitial lung disease -- Occupational lung disease -- Pulmonary vascular disease -- Pneumothorax and pleural effusion -- Acute respiratory distress syndrome -- Sleep-related breathing disorders -- Lung transplantation--Smoking and smoking cessation.

Taking a cardiovascular history -- Examination of the cardiovascular system -- The electrocardiogram -- Imaging -- Hypertension -- Coronary heart disease -- Thrombosis in cardiovascular disease -- The myocardium -- Heart failure -- Valvular heart disease -- The endocardium -- The pericardium -- Electrophysiology -- Cardiopulmonary resuscitation -- Diseases of the aorta -- Pulmonary hypertension and pulmonary thromboembolism -- Pregnancy and the heart -- Congenital heart disease -- Heart disease in the elderly -- Cardiac tumours -- Surgery and anaesthesia -- Cardiology, the law and occupation.

Anaesthetic assessment and preparation for surgery -- Anaesthesia -- Postanaesthesia care -- Management of perioperative emergencies and cardiac arrest -- Recognition and management of the critically ill patient -- Anaesthetists and chronic pain.

Assessment and preparation for surgery -- The principles of anaesthesia -- The practice of anaesthesia -- Postanaesthesia care -- Recognition and management of the acutely ill patient on the ward -- Management of the critically ill patient.

Requesting and interpreting tests -- Disturbances of water, sodium and potassium balance -- Acid-base balance and oxygen transport -- Renal disease -- Disorders of calcium, phosphate and magnesium metabolism -- Trauma, inflammation, immunity and malignancy -- Liver disease -- Gastrointestinal tract disease -- Nutrition -- Diabetes mellitus and hypoglycaemia -- Cardiovascular disorders -- Disorders of iron and porphyrin metabolism -- Uric acid, gout and purine metabolism -- Disorders of the hypothalamus and pituitary -- Abnormalities of thyroid function -- Disorders of the adrenal cortex and medulla -- Investigation of gonadal function, infertility, menstrual irregularities and hirsutism -- Pregnancy and antenatal screening -- Clinical biochemistry in paediatrics and geriatrics -- Central nervous system and cerebrospinal fluid -- Therapeutic drug monitoring and chemical toxicology.

Structure and function of the skin, hair and nails -- Approach to the diagnosis of dermatological disease -- Bacterial and viral infections -- Fungal infections -- Ectoparasite infections -- Acne, acneiform eruptions and rosacea -- Eczema -- Psoriasis -- Benign and malignant skin tumours -- Naevi -- Inherited disorders -- Pigmentary disorders -- Disorders of the hair and nails -- Bullous disorders -- Miscellaneous erythematous and papulosquamous disorders and light-induced skin diseases -- Vascular disorders -- Connective tissue disorders -- Pruritus -- Systemic disease and the skin -- Skin and the psyche -- Cutaneous drug reactions -- Treatment of skin disease.

The principles of emergency medicine -- Major trauma and multiple injuries -- Head injuries -- The neck and the back -- Facial injuries -- Injuries to the trunk -- The lower limb -- The upper limb -- The hand -- Burns -- Cardiac arrest and cardiac dysrhythmias -- Chest pain -- Respiratory distress -- Collapse and sudden illness - Poisoning -- Abdominal pain -- Obstetric, gynaecological, genitourinary and perineal problems - Children's problems in the emergency department -- The disturbed patient -- Medicolegal aspects of emergency medicine -- Small wounds and localized infections -- Ophthalmic, ENT and facial conditions.

Epidemiology -- Prevention and control of disease -- Health services.

Normal haemoglobin, blood cells, and haemopoiesis -- Anaemia and polycythaemia: general considerations -- Haemolytic anaemias -- Iron metabolism, iron deficiency anaemia, other hypochromic microcytic anaemias, and iron overload -- Macrocytosis and macrocytic anaemia -- Conditions causing white cell abnormalities -- Structure and function of lymphoid tissue -- Lymphomas: general principles -- Classification of lymphoma -- Hodgkin's lymphoma and some of the commoner clinical entities of non-Hodgkin's lymphomas, including ALL and CLL -- Myeloma and other paraproteinaemias -- Neoplastic disorders of myeloid cells -- Bone marrow transplantation -- Aplastic anaemia and pure red cell aplasia -- Haemostasis, abnormal bleeding, and anticoagulant therapy -- Blood transfusion and haemolytic disease of the newborn -- Basic haematological techniques and reference ranges.

Cell physiology -- Cellular communication -- Introduction to the nervous system -- Signalling in the nervous system -- Muscle -- Sensory systems -- Special senses -- Motor system -- Higher nervous functions -- Pain -- Endocrine system -- Reproduction -- Blood -- Introduction to the cardiovascular system -- Cardiovascular system--the heart -- Vascular system -- Cardiovascular regulation, regional circulation and circulatory adjustments -- Respiration -- Digestive system -- Kidney -- Fluid and electrolyte balance -- Energy metabolism -- Temperature regulation -- Exercise.

Basic bacteriology : structure -- Basic bacteriology : physiology -- Basic bacteriology : genetics -- Classification of bacteria -- Staphylococci -- Streptococci and enterococcci -- Clostridia -- Other gram-positive bacteria -- Gram-negative cocci -- Enterobacteriaceae -- Parvobacteri -- Pseudomonas and other aerobic gram-negative bacilli -- Campylobacter, helicobacter, and vibrios -- Treponema, borrelia, and leptospira -- Gram-negative anaerobic bacteria -- Mycobacteria --Chlamydiae, rickettsiaceae, mycoplasma -- Basic virology -- Major virus groups -- Basic mycology and classification of fungi -- Parasitology : protozoa -- Parasitology : metazoa (helminths) -- Host-parasite relationships -- Diagnostic laboratory methods -- Epidemiology and prevention of infection -- Management of infections -- Immunisation -- Sterilisation and disinfection -- Antibacterial agents -- Antifungal agents -- Antiviral agents -- Upper respiratory tract infections --Lower respiratory tract infections -- Gastrointestinal infections -- Liver and biliary tract infections -- Urinary tract infections -- Genital infections (including sexually transmitted diseases) -- Infections of central nervous system -- Septicaemia and bacteraemia -- Device-related infections -- Drug-resistant microorganisms -- Cardiovascular infections -- Bone and joint infections -- Skin and soft-tissue infections -- Infections in the compromised host -- Perinatal and congenital infections -- Human immunodeficiency viruses -- Miscellaneous viral infections.

Neurological history-taking -- Consciousness -- Cognitive function -- Vision and other cranial nerves -- Motor function -- Sensation -- Autonomic function -- Investigating the patient -- -- Headache and facial pain -- Epilepsy -- Stroke -- Parkinson's disease and other movement disorders -- Neurosurgical topics: head injury and brain tumour -- Neurological infections -- Spinal conditions -- Multiple sclerosis -- Nerve and muscle -- Development and degeneration -- Neurology and other medical specialties -- Neurological emergencies -- Neurorehabilitation.

Neurological history-taking -- Consciousness -- Cognitive function -- Vision and other cranial nerves -- Motor function -- Sensation -- Autonomic function -- Investigating the patient -- Headache and facial pain -- Epilepsy -- Stroke -- Parkinson's disease and other movement disorders -- Neurosurgical topics : head injury and brain tumour -- Neurological infections -- Spinal conditions -- Multiple sclerosis -- Nerve and muscle -- Development and degeneration -- Neurology and other medical specialties -- Neurological emergencies -- Neurorehabilitation.

Basic science -- The woman as a patient -- Puberty and menstrual problems of young women -- Subfertility -- Pregnancy prevention -- Benign diseases, genital tract infections and sexual problems -- The mother and fetus in pregnancy -- Bleeding in pregnancy -- The antenatal period -- Diseases of pregnancy -- Diseases in pregnancy -- Normal labour -- Abnormal labour -- Puerperium -- The newborn -- Abnormal vaginal blood loss -- Pelvic pain -- Breast disease -- Screening for gynaecological cancer -- Malignant gynaecological conditions -- The menopause -- Pelvic floor disorders -- Statistics of reproductive medicine.

Anatomy -- History and examination -- Clinical optics -- The orbit -- The eyelids -- The lacrimal system -- Conjuctiva, cornea and sclera -- The lens and cataract -- Uveitis -- Glaucoma -- Retina and choroid -- Retinal vascular disease --The pupil and its responses -- The visual pathway -- Eye movements and their disorders -- Trauma -- Tropical ophthalmology : eye diseases in the developing world -- Symptoms of eye disease -- Services for the visually handicapped -- Clinical cases -- Useful references.

Musculoskeletal structures and function -- Soft tissue injuries and healing -- Nerve injuries and repair -- Fractures and healing -- Fractures : principles of management -- Complications of fractures -- Major trauma -- Congenital malformations -- Generalised orthopaedic conditions -- Inflammatory conditions -- Degenerative conditions -- Neoplastic conditions of bone and soft tissue -- Infections -- Metabolic diseases of bone -- Examination of the musculoskeletal system -- The forearm, wrist, and hand -- The elbow -- The shoulder and upper arm -- The spine -- The pelvis -- The hip and thigh -- The knee and lower leg -- The foot and ankle -- Orthopaedic techniques.

Respiratory tract -- Cardiovascular system -- Gastrointestinal tract -- Liver and pancreas -- Urinary tract -- Skeletal system -- Skeletal trauma -- Paediatrics -- Obstetrics and gynaecology -- Neuroradiology -- Specific radiological investigations -- Film-viewing hints.

Respiratory tract -- Cardiovascular system -- Gastrointestinal tract -- Liver and pancreas -- Urinary tract -- Musculoskeletal system -- Trauma -- Paediatrics -- Obstetrics and gynaecology -- Neuroradiology -- Specific radiological investigations -- Film-viewing hints.

Introduction: Bateson the precursor /Jesper Hoffmeyer --Angels fear revisited: Gregory Bateson's cybernetic theory of mind applied to religion-science debates /Mary Catherine Bateson --From thing to relation. On Bateson's bioanthropology /Jesper Hoffmeyer --What connects the map to the territory? /Tyrone Cashman --The pattern which connects pleroma to creatura: the autocell bridge from physics to life /Terrence Deacon and Jeremy Sherman --Bateson's method: double description. What is it? How does it work? What do we learn? /Julie Hui, Tyrone Cashman, and Terrence Deacon --Gregory Bateson's relevance to current molecular biology /Luis Emilio Bruni --Process ecology: creatura at large in an open universe /Robert E. Ulanowicz --Connections in action - bridging implicit and explicit domains /Teresa S.S. Shilhab and Christian Gerlach --Bateson: biology with meaning /Brian Goodwin --Gregory Bateson's "uncovery" of ecological aesthetics /Peter Harries-Jones --Collapsing the wave function of meaning: the epistemological matrix of talk-in-interaction /Donald Favareau --Re-enchanting evolution: transcending fundamentalisms through a mythopoetic epistemology /Gregory Mengel --Bateson and Peirce on the pattern that connects and the sacred /Søren Brier --Bateson, Peirce and the sign of the sacred /Deborah Eicher-Catt.

Section I. Radiation biology and physics -- Section II. Imaging -- Section III. Radiation oncology -- Part 1. Central nervous system -- Part 2. Head and neck tumors -- Part 3. Tumors of the thorax -- Part 4. Gastrointestinal tumors -- Part 5. Urologic tumors -- Part 6. Gynecologic tumors -- Part 7. Pediatric tumors -- Part 8. Cancer of the breast -- Part 9. Adult sarcomas -- Part 10. Lymphomas -- Part 11. Ocular cancer -- Part 12. Skin cancer -- Part 13. Benign disease -- Section IV. Emerging radiation modalities.

Lemur origins, history of ecological studies on lemurs, and the ecology of the recently extinct (subfossil) lemurs --Origin of the Malagasy strepsirhine primates /Ian Tattersall --Notes on the history of ecological studies of Malagasy lemurs /Alison Jolly and R.W. Sussman --Ecology and extinction of Madagascar's subfossil lemurs /Laurie R. Godfrey, William L. Jungers, and Gary T. Schwartz --The evolution of lemur traits, basic and unusual patterns --Impact of ecology on the teeth of extant lemurs :a review of dental adaptations, function, and life history /Frank P. Cuozzo and Nayuta Yamashita --Big is beautiful :fat storage and hibernation as a strategy to cope with marked seasonality in the fat-tailed dwarf lemur (Cheirogaleus medius) /Joanna Fietz and K.H. Dausmann --Polyspecific associations of crowned lemurs and Sanford's lemurs in Madagascar /Benjamin Z. Freed --Cathemerality in lemurs /Deborah J. Curtis --Adaptations in the aye-aye :a review /Eleanor J. Sterling and Erin E. McCreless --Connecting ecology and adaptation : summaries and new studies --Evolutionary divergence in the brown lemur species complex /Steig E. Johnson --Ecological diversity and seasonal adaptations of mouse lemurs (Microcebus spp.) /Ute Radespiel --Social pair-bonding and resource defense in wild red-bellied lemurs (Eulemur rubriventer) /Deborah J. Overdorff and Stacey R. Tecot --Lemur catta ecology :what we know and what we need to know /Lisa Gould --Impact of seasonality and reproduction on social structure, ranging patterns, and fission-fusion social organization in red ruffed lemurs /Natalie Vasey --Ecologically enigmatic lemurs :the sifakas of the eastern forests (Propithecus candidus, P. diadema, P. edwardsi, P. perrieri, P. tattersalli) /Mitchell T. Irwin --Behavioral and ecological adaptations in two small folivorous lemurs with different social organization :Avahi and Lepilemur /Urs Thalmann --The feeding ecology and related adaptations of Indri indri /Joyce A. Powzyk and Christopher B. Mowry --Behavior and ecology of gentle lemurs (genus Hapalemur) /Chia L. Tan --Lemur adaptations to a changing environment, natural and anthropogenic stress --Considering climate change effects in lemur ecology and conservation /Patricia C. Wright --Diet composition, foraging, and feeding behavior in relation to habitat disturbance :implications for the adaptability of ruffed lemurs (Varecia variegata editorium) in Manombo Forest, Madagascar /Jonah Ratsimbazafy --Overview on the health and disease ecology of wild lemurs :conservation implications /Randall E. Junge and Michelle L. Sauther

David Escors and Karine Breckpot --Development of Retroviral and Lentiviral Vectors /David Escors, Grazyna Kochan, Holly Stephenson and Karine Breckpot --Cell and Tissue Gene Targeting with Lentiviral Vectors /David Escors, Grazyna Kochan, Holly Stephenson and Karine Breckpot --Immunomodulation by Genetic Modification Using Lentiviral Vectors /Frederick Arce, Karine Breckpot, Grazyna Kochan and David Escors --Clinical Grade Lentiviral Vectors /Grazyna Kochan, David Escors, Holly Stephenson and Karine Breckpot --Human Gene Therapy with Retrovirus and Lentivirus Vectors /Grazyna Kochan, Holly Stephenson, Karine Breckpot and David Escors.

Part 1.GENERAL SECTION /History and Phylogeography of Leprosy /Stewart T. Cole and Pushpendra Singh --Microbiology /Andrea Clapasson and Silvia Canata --Genetics of Leprosy /Vinicius Medeiros Fava and Marcelo Távora Mira --Host Response to M. leprae /Rodrigo Ribeiro-Rodrigues --Pathogenesis /Cesare Massone and Enrico Nunzi --Classification /Cesare Massone and Alexandra M. G. Brunasso --Part 2.PATIENT'S EXAMINATION --Patient History /Enrico Nunzi, Cesare Massone and Salvatore Noto --Laboratory Investigations /Andrea Clapasson and Silvia Canata --Part 3.SKIN --Physical Examination: Skin /Enrico Nunzi, Cesare Massone and Salvatore Noto --Clinical Features /Enrico Nunzi, Cesare Massone and Salvatore Noto --Lucio-Latapí Leprosy /Mario Magaña --Histopathology of the Skin /Cesare Massone --Differential Diagnosis: Skin /Enrico Nunzi and Salvatore Noto --Part 4.NERVES --Peripheral Nerves in Leprosy /Bernard Naafs and José Antônio Garbino --The Leprosy Neuropathy /Lizia Reni, Salvatore Noto and Pieter A. M. Schreuder --Primary Neural Leprosy /José Antônio Garbino and Bernard Naafs --Chronic Neuropathic Pain in Leprosy /José Antônio Garbino, Bernard Naafs and Pedro Schestatsky --Electrodiagnostic Studies /Lizia Reni --Imaging /Carlo Martinoli, Leila Oppezzi and Alberto Tagliafico --Differential Diagnosis: Nerves /Lizia Reni.Part 5.Reactions in Leprosy /Reactions in Leprosy /Bernard Naafs and Salvatore Noto --Lucio's Phenomenon /Mario Magaña --Part 6.SYSTEMIC INVOLVEMENT --Ocular Involvement in Leprosy /Susan Lewallen and Paul Courtright --Otolaryngological Manifestations of Leprosy /Sinésio Talhari, Camila Bandeira de Oliveira and Carolina Talhari --Other Organs /Enrico Nunzi and Salvatore Noto --Part 7.PATIENT'S MANAGEMENT --Diagnostic Work-Up /Enrico Nunzi, Cesare Massone and Salvatore Noto --Drugs in Leprosy /Sinésio Talhari and Mahreen Ameen --Treatment and Prophylaxis /Pierre Bobin --Prognosis /Enrico Nunzi --Neurolysis /Sergio S. G. Gennaro --Prevention of Disability and Ulcer Care /J. Wim Brandsma and Hugh Cross --Surgical and Social Rehabilitation /J. Wim Brandsma and Sunil Deepak --Part 8.LEPROSY AND COMMUNITY --Leprosy in Pregnancy /Elizabeth Duncan --Leprosy and HIV/AIDS Co-infection /Sinésio Talhari and Carolina Talhari --Epidemiology of Leprosy /Salvatore Noto and Pieter A. M. Schreuder --Leprosy Control /Sunil Deepak and Giovanni Gazzoli --Teledermatology /Cesare Massone and Antonio Pedro Mendes Schettini --The Leprosy Mailing List /Salvatore Noto.

"Angela Ki Che Leung's meticulous study begins with the classical annals of the imperial era, which contain the first descriptions of a feared and stigmatized disorder modern researchers now identify as leprosy. She then tracks the relationship between the disease and China's social and political spheres (theories of contagion prompted community and statewide efforts at segregation); religious traditions (Buddhism and Daoism ascribed redemptive meaning to those suffering from the disease), and evolving medical discourse (Chinese doctors have contested the disease's etiology for centuries). Leprosy even pops up in Chinese folklore, attributing the spread of the contagion to contact with immoral women." "Leung next places the history of leprosy into a global context of colonialism, racial politics, and "imperial danger." A perceived global pandemic in the late nineteenth century seemed to confirm Westerners' fears that Chinese immigration threatened public health. Therefore battling to contain, if not eliminate, the disease became a central mission of the modernizing, state-building projects of the late Qing empire, the nationalist government of the first half of the twentieth century, and the People's Republic of China." "Stamping out the curse of leprosy was the first step toward achieving "hygienic modernity" and erasing the cultural and economic backwardness associated with the disease. Leung's final move connects China's experience with leprosy to a larger history of public health and biomedical regimes of power, exploring the cultural and political implications of China's Sino-Western approach to the disease."--Jacket.

Sources of liability: Forms of legal complaints -- Duty as an element of a lawsuit: obligations and responsibilities -- Duty as an element of a lawsuit: sources of standards -- Duty as an element of a lawsuit: procedural requirments -- Breach, causation, and damages as elements of a lawsuit -- Defenses to a lawsuit -- Communication.

Acute leukaemia: cytology, cytochemistry and the FAB classification -- Acute leukaemia: immunophenotyping, cytogenetics and molecular genetics-the EGIL, MIC, MIC-M and WHO classifications -- Myelodysplastic syndromes -- Chronic myeloid leukaemias and mixed myeloproliferative/myelodysplastic conditions -- Chronic lymphoid leukaemias.

The nature of leukaemia, cytology, cytochemistry and the FAB classification of acute leukaemia -- Immunophenotyping and cytogenetic/molecular genetic analysis in leukaemia and related conditions -- Acute leukaemia : integration of morphological, immunophenotypic, and genetic information and the WHO classification -- The myelodysplastic syndromes -- Chronic myeloid leukaemias -- Lymphoid leukaemias of mature T, B and natural killer cells.

An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia / C.W. So -- Backtracking of leukemic clones to birth / J. Wiemels, M. Kang and M. Greaves -- Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia / Z.J. Konn ... [et al.] -- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research / L. Kearney and S. Colman -- LDI-PCR: identification of known and unknown gene fusions of the human MLL gene / C. Meyer and R. Marschalek -- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences / B.W. Robinson and C.A. Felix -- MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR / V.H. van der Velden and J.J. van Dongen -- Array-based comparative genomic hybridization as a tool for analyzing the leukemia genome / J.C. Strefford and H. Parker -- Application of SNP genotype arrays to determine somatic changes in cancer / M. Gupta and B.D. Young -- Retroviral/Lentiviral transduction and transformation assay / B.B. Zeisig and C.W. So -- Gene expression profiling of leukemia stem cells / A.V. Krivtsov ... [et al.] -- Humanized model to study leukemic stem cells / D. Bonnet -- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction / M. Wunderlich and J.C. Mulloy -- Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells / J.J. Schuringa and H. Schepers -- Identification and characterization of hematopoietic stem and progenitor cell populations in mouse bone marrow by flow cytometry / J. Yeung and A.C. Wai Eric So -- In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development / P. Sroczynska ... [et al.] -- Analysis of the mouse placenta as a hematopoietic stem cell niche / K. Ottersbach and E. Dzierzak -- Identification of protein interaction partners by the yeast two-hybrid system / M.P. Garcia-Cuellar, D. Mederer and R.K. Slany -- Complete array of HOX gene expression by RQ-PCR / G.J. Dickson, T.R. Lappin and A. Thompson -- Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias / M.E. Figueroa, A. Melnick and J.M. Greally -- Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins / T.A. Milne, K. Zhao and J.L. Hess.

Introduction to dermatopathologic diagnosis -- Biopsy techniques -- Histology of the skin -- Laboratory methods -- Algorithmic classification of skin disease for differential diagnosis -- Congenital diseases (genodermatoses) -- Noninfectious erythematous, papular, and squamous diseases -- Vascular diseases -- Noninfectious vesiculobullous and vesiculopustular diseases -- Connective tissue diseases -- Cutaneous toxicities of drugs -- The photosensitivity disorders --Diseases caused by viruses -- The histiocytoses -- Pigmentary disorders of the skin -- Benign pigmented lesions and malignant melanoma -- Tumors and cysts of the epidermis -- Tumors of the epidermal appendages -- Cutaneous lymphomas and leukemias -- Tumors of fibrous tissue involving the skin -- Vascular tumors: tumors and tumor-like conditions of blood vessles and lymphatics --Tumors with fatty, muscular, osseous, and cartilagenous differentiation -- Tumors of neural tissue -- Metastatic carcinoma of the skin: incidence and dissemination.Disorders associated with physical agents: heat, cold, radiation, and trauma -- Noninfectious granulomas -- Degenerative diseases and perforating disorders -- Cutaneous manifestations of nutritional deficiency states and gastrointestinal disease -- Metabolic diseases of the skin -- Inflammatory diseases of hair follicles, sweat glands, and cartilage -- Inflammatory diseases of the nail -- Inflammatory diseases of the subcutaneous fat -- Bacterial diseases -- Treponemal diseases -- Fungal diseases -- Protozoan diseases and parasitic infestations --

The heritage of pharmacology -- The scope of pharmacology -- How drugs act on the living organism -- How drugs reach their site of action: -- I. General principles of passage of drugs across biologic barriers. -- II. Absorption. -- III. Distribution -- How the actions of drugs are terminated: -- I. Excretion. -- II. Biotransformation -- General principles of the quantitative aspects of drug action: -- I. Dose-response relationships. -- II. Time-response relationships -- Factors modifying the effects of drugs in individuals: -- I. Variability in response attributable to the biologic system. -- II. Variability in response attributable to the conditions of administration -- Drug toxicity -- How drugs alter physiologic function -- The pharmacologic aspects of drug abuse -- The development and evaluation of new drugs.

Includes a database of bibliographic resources, a database of library automation companies, and a database of online catalogs and Web pages (lib-web-cats).

Provides on-line access to images that are characteristic of a wide array of hematological disorders and other disorders that affect the blood, enhancing written descriptions found in Williams Hematology and other relevant medical books.

A time of crisis --A secular value of life --Vital mobility --Moral witness --Human frontiers --The problem of triage --The longue durée of disease --The verge of crisis --Action beyond optimism.

Part I. Reviews -- 1. An Historical overview of drug discovery / Ana Sofia Pina, Abid Hussain, and Ana Cecília Roque -- 2. Ligand macromolecule interactions : theoretical principles of molecular recognition / Tammy Nolan, Nidhi Singh, and Christopher R. McCurdy -- 3. X-Ray cystallography in drug discovery / Ana Luísa Carvalho, José Trincão, and Maria João Romão -- 4. Virtual screening of compound libraries / Nuno M.F.S.A. Cerqueira, Sérgio F. Sousa, Pedro A. Fernandes, and Maria João Ramos -- Part II: Protocols -- 5. Combinatorial chemistry and the synthesis of compound libraries / Rolf Breinbauer and Matthias Mentel -- 6. Ligand-based nuclear magnetic resonance screening techniques / Aldino Viegas, Anjos L. Macedo, and Eurico Cabrita -- 7. Isothermal titration calorimetry and differential scanning calorimetry / Geoff Holdgate -- 8. Adaptive combinatorial design of focused compound libraries / Gisbert Schneider and Andreas Schüller -- 9. Chemical microarrays : a new tool for discovery enzyme inhibitors / Shuguang Liang, Wei Xu, Kurumi Y. Horiuchi, Yuan Wang, and Haiching Ma -- 10. Fluorescence polarization and time-resolved fluorescence resonance energy transfer techniques for PI3K assays / Kurumi Y. Horiuchi and Haiching Ma -- 11. Small molecule protein interaction profiling with functional protein microarrays / Lihao Meng, Dawn Mattoon, and Paul Predki -- 12. Capillary electrophoresis in drug discovery / Milena Quaglia and Ersilia De Lorenzi -- 13. SPR in drug discovery : searching bioactive compounds in plant extracts / Maria Minunni and Anna Rita Bilia -- 14. Application of frontal affinity chromatography with mass spectrometry (FAC-MS) for stereospecific ligand-macromolecule interaction, detection and screening / Jacek Slon-Usakiewicz and Peter Redden -- 15. GPC spin column HPLC-ESI-MS methods for screening drugs noncovalently bound to proteins / Marshall M. Siegel -- 16. A scintillation proximity assay for fatty acid amide hydrolase compatible with inhibitor screening / Yuren Wang and Philip Jones -- 17. A natural products approach to drug discovery : probing modes of action of antitumor agents by genome-scale cDNA library screening / Hendrik Luesch and Pedro Abreu -- 18. Ligand-macromolecule interactions in live cells by fluorescence correlation spectroscopy / Aladdin Pramanik

Glycol methacrylate embedding for improved morphological, morphometrical, and immunohistochemical investigations under light microscopy : testes as a model /Hélio Chiarini-Garcia, Gleydes Gambogi Parreira, and Fernanda R.C.L. Almeida --Histological processing of teeth and periodontal tissues for light microscopy analysis /Gerluza Aparecida Borges Silva, Adriana Moreira, and José Bento Alves --Large plant samples: how to process for GMA embedding /Élder Antônio Sousa Paiva, Sheila Zambello de Pinho, and Denise Maria Trombert Oliveira --Image cytometry : nuclear and chromosomal DNA quantification /Carlos Roberto Carvalho, Wellington Ronildo Clarindo, and Isabella Santiago Abreu --Histological approaches to study tissue parasitism during the experimental Trypanosoma cruzi infection /Daniela L. Fabrino, Grazielle A. Ribeiro, Livia Teixeira, and Rossana C.N. Melo --Intravital microscopy to study leukocyte recruitment in vivo /Vanessa Pinho ... [et al.] --Introduction to fluorescence microscopy /Ionita C. Ghiran --Using the fluorescent styryl dye FM1-43 to visualize synaptic vesicles exocytosis and endocytosis in motor nerve terminals /Ernani Amaral, Silvia Guatimosim, and Cristina Guatimosim --Imaging lipid bodies within leukocytes with different light microscopy techniques /Rossana C.N. Melo ... [et al.] --Eicosa cell : an immunofluorescent-based assay to localize newly synthesized eicosanoid lipid mediators at intracellular sites /Christianne Bandeira-Melo, Peter F. Weller, and Patricia T. Bozza --Nestin-driven green fluorescent protein as an imaging marker for nascent blood vessels in mouse models of cancer /Robert M. Hoffman --Imaging calcium sparks in cardiac myocytes /Silvia Guatimosim, Cristina Guatimosim, and Long-Sheng Song --Light microscopy in aquatic ecology: methods for plankton communities studies /Maria Carolina S. Soares ... [et al.] --Fluorescence immunohistochemistry in combination with differential interference contrast microscopy for studies of semi-ultrathin specimens of epoxy resin-embedded samples /Shin-ichi Iwasaki and Hidekazu Aoyagi.