• Kotter, John P.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008From: Springer
    Oliver Gassmann, Gerrit Reepmeyer, Maximilian von Zedtwitz.
  • Neil A. Grauer.
    1889-1939 : the first fifty years -- 1940-1988 : Hopkins Medicine moves into the modern era -- 1989-1993 : celebrations and changing of the guard -- 1994 -1998 : overcoming turmoil and addressing challenges -- 1999-2003 : tested to the limit, surmounting crises -- 2001-2011 : creating a new Johns Hopkins Medicine.
  • 2008From: Springer
    Gunter Dueck.
    Lean brain : the greatest challenge of the future -- On the way to LBQ -- The automatic control of a lean brain system -- Inhibitors of LBQ and counteractive measures -- Stereotypical activity in the blood! -- Suggestions for concrete transformations of the world -- The metaphysics of lean brain thought -- Musoleum Germany -- Brain rest.
  • 2014From: Springer
    Nilmini Wickramasinghe, Latif Al-Hakim, Chris Gonzalez, Joseph Tan, editors.
    A growing, aging population; the rise to epidemic proportions of various chronic diseases; competing, often overlapping medical technologies; and of course, skyrocketing costs compounded by waste and inefficiency - these are just a few of the multifarious challenges currently facing healthcare delivery. An unexpected source of solutions is being imported from the manufacturing sector: lean thinking. "Lean Principles for Healthcare" presents a conceptual framework, management principles, and practical tools for professionals tasked with designing and implementing modern, streamlined healthcare systems or overhauling faulty ones. Focusing on core components such as knowledge management, e-health, patient-centeredness, and collaborative care, chapters illustrate lean concepts in action across specialties (as diverse as nursing, urology, and emergency care) and around the globe. Extended case examples show health systems responding to consumer needs and provider realities with equal efficiency and effectiveness, and improved quality and patient outcomes. Further, contributors tackle the gamut of technological, medical, cultural, and business issues.
  • From: NLM
    Includes workbook: TOXNET & Beyond-- Using the National Library of Medicine® Environmental Health & Toxicology Portal.
  • Ritschel, W. A.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2012From: Springer
    Antonio Luna, Joan C. Vilanova, Pablo R. Ros (editors).
    This book is an ideal introduction to the use of radiology in imaging diseases of the liver, gallbladder and biliary system, pancreas, spleen, and gastrointestinal tract. Each of the ten chapters is devoted to a particular organ and contains ten illustrated case reports drawn from clinical practice. Common clinical situations and indications for imaging are reviewed, and clear descriptions are provided of the various imaging techniques that will assist in resolving diagnostic and therapeutic dilemmas. This book is recommended for medical students, residents, and inexperienced abdominal radiologists.
  • 2014From: Springer
    Charles C. Tseng, Xiaoli Yang.
    Learning Basic Genetics with Interactive Computer Programs is a comprehensive and interactive learning program that focuses on chromosome simulation and model building. It is intended to assist students in learning more about genetics with ease. The 11 modules of this program form an integrated system for learning the basic concepts of genetics. The program innovation lies in its unique content design that incorporates cognitive feedback and experiential learning through the novel use of interactive applications. Each of the modules is designed to enhance learning by simultaneously employing "eyes-on," "minds-on," and "hands-on" activities. Topics are motivated by questions, information is presented in simple terms, and concepts are clarified by interactive prompts. Used as a supplement to traditional lectures and textbook assignments, the program not only serves as a foundation upon which to build more complex and detailed topics, but as a tutor to clarify and guide when there is confusion. The software that accompanies this book has been shown to be an ideal tool for learning about genetics, which requires a combination of understanding, conceptualization, and practical experience.
  • Jesse Liberty and Brian MacDonald.
  • 2015From: Springer
    Allen J. Taylor, Editor.
    The foundation of this handbook lies in the supremacy of careful, clinical observation in medicine. The science and application of auscultation, albeit not without its imperfections, represent a learnable, tangible, personal approach to assessment of the heart and remains crucial in medical practice. Today's medicine tends towards the high tech, discarding simple approaches that can and should steer clinicians towards when to utilize expensive testing, and at the most can, potentially, outperform technology for accurate cardiovascular diagnosis. Within a cost conscious, personalized approach to medicine, the art of clinical examination of the heart could never be more alive, or more important. Technology needs a clinically informed platform upon which to provide benefits to patients with careful clinical observation providing proper identification of patients in need of additional testing and avoiding unnecessary expensive testing. Learning Cardiac Auscultation: From Essentials to Expert Clinical Interpretation provides a clinically-oriented approach to the astute observation of heart sounds and other aspects of the cardiovascular examination. It describes key clinical and auscultation features, and clinical clues to the diagnosis. More importantly, auscultation of the heart should not just end with a simple diagnosis, but an unearthing of nuances of the diagnosis, for example, describing the possible severity or diagnostic implications of the auscultation findings.
  • 2010From: Springer
    [edited by] R. Ribes ... [et al.].
  • 2013From: Springer
    John C. Pedrozo Pupo (editor).
    Pleural and Pleural Space -- Diaphragm -- Mediastinum and Pulmonary Circulation -- Air Space and Bronchi - I -- Air Space and Bronchi - II -- Trachea and Airway -- Heart and Great Vessels -- Chest Wall and Soft Tissues -- Pulmonary Interstitium -- Medical Device and Monitoring of the Chest.
  • 2008From: Springer
    R. Ribes, A. Luna, P.R. Ros. (eds.) ; with contributions by L. Alcala Mata ... [et al.].
  • [Jerome Hellmuth, editor].
    PrintStatus: Not Checked OutLane Catalog Record
  • Casey M. Lindberg.
    The story of old age is not one of pure loss. Indeed, old age represents a time of certain cognitive decline in some domains, but also a time of growth and stability in others. Wisdom, maturity, expertise, and emotional regulation show improvements across adulthood. Goals also shift over the life span, from those aimed at gaining information and preparing for the future to emotionally meaningful pursuits later in life. These differences lead to goal-consistent cognitive biases in the young and the old. Younger people attend to negative information more than positive information. Older adults attend to positive information more than negative information. This developmental shift, called the positivity effect, is presumably adaptive in a life-span context. Yet either set of chronically activated goals can be maladaptive in certain contexts. Because the positivity effect is malleable -- influenced by the way task relevant goals are structured -- it may be possible to frame information in ways that reduce biases in young and old. The present program of research aims to show how biases can be reduced when participants are given information about relevant research findings and have the necessary psychological tools to adjust their behavior accordingly. No previous work has investigated the impact of disclosing information about the positivity effect directly to participants. Such an informed debiasing attempt could prove fruitful for future attempts to educate the public about their own attentional biases. Study 1 demonstrates the positivity effect in a picture recall task; Study 2 adds images to an existing image set in order to more accurately study debiasing of the positivity effect in future studies; Study 3 demonstrates that people are generally unaware of the positivity effect; Study 4 demonstrates that simple information disclosure about the positivity effect is insufficient to change participants' behavior on a picture presentation/recall task and a health care decision task; Study 5 demonstrates that participants' motivation to change is key to behavior change.
  • 2012From: Springer
    Joan C. Vilanova, Antonio Luna, Pablo R. Ros (editors).
    This introduction to genitourinary and pelvic radiology is a further volume in the Learning Imaging series. Written in a case-based format, the book is subdivided into ten chapters: kidney; adrenal gland; urinary bladder, collecting system and urethra; prostate and seminal vesicles; scrotum; obstetrics; uterus; cervix and vagina; adnexa and retroperitoneum. Genitourinary radiology has undergone a tremendous change owing to advances in ultrasound, CT and MRI that have redefined our understanding of genitourinary and pelvic pathology. Each chapter includes an introduction and ten case studies with illustrations and comments from anatomical, physiopathological and radiological standpoints and with bibliographic recommendations. Learning Genitourinary and Pelvic Imaging will be of value for radiologists, radiology residents, medical students and anybody else working in genitourinary and pelvic pathology.Learning Imaging is a unique case-based series for those in professional education in general and for physicians in particular.
  • 2016From: Oxford Medicine Online
    Berenice C. Langdon, Aodhán S. Breathnach.
    'Learning Microbiology through Clinical Consultation' is a highly accessible text which describes the fundamentals of microbiology within the practice setting in an informative way. It is an ideal resource for medical students and newly qualified doctors, as well as anyone wishing to study medicine or preparing for medical school interviews.
  • 2010From: Springer
    R. Ribes, J.C. Vilanova (eds.).
  • 2006Click LINK above for Print location/circulation status.
    2006From: ProQuest Safari
    Seyed M.M. "Saied" Tahaghoghi and Hugh E. Williams.
  • Bokyung Choi.
    Learning networks from experimental evidence is an important problem to understand many biological systems. With the help of recent technological developments, such as high dimensional flow cytometry and gene expression arrays, a large amount of quality data are available for the task. Many different approaches exist, to model and learn biological networks from such data. Among those, we have developed methods for probabilistic models and differential equation models. The first part of this paper will cover our research on the Gaussian network model learning and its application to recover signal transduction networks. We develop a fast algorithm to learn Gaussian networks from data, based on a novel heuristic. We show that this algorithm can be extended to handle difficult situations such as non-Gaussian noise as well as limited number of simultaneous measurements. The performance of the algorithm against the standard alarm network is showed. Finally we apply the method to learn signal transduction networks from single cell level multi- channel flow cytometry data. We show that the method can recover networks with limited number of channels and non-Gaussian measurement noise. The second part will cover our research on the dynamical model of gene regulation. In this model, gene regulation is represented with differential equations in rational forms. We show that this type of model is able to reflect complex behaviors of gene regulation, compared to other existing models. Reconstucting the structure and parameters of such dynamical model is not trivial, given that limited measurability of gene expression. We develop a novel method to recover networks from measurements at so-called perturbed equilibrium. We show that this method can reconstruct gene regulatory networks with well-established experimental designs. Model benchmark based on simulation data will be presented.
  • 2012From: Springer
    Francisco de Asís Bravo-Rodríguez, Rocío Díaz-Aguilera, Luis Celso Hygino da Cruz Jr. (editors).
  • 2011From: Springer
    María I. Martínez León, Luisa Ceres Ruiz, Juan E. Gutiérrez (Editors).
    Tumoral neurology [cases]: Pilocytic astrocytoma -- Pilomyxoid astrocytoma -- Ependymoma -- Infrequent presentation of medulloblastoma -- Brainstem tumors -- Choroid plexus tumors -- Atypical teratoid/rhabdoid tumor of the CNS -- Glioblastoma -- Rhabdomyosarcoma -- Pineoblastoma -- Tumoral and non-tumoral neurology [cases]: Nasal chondromesenchymal hamartoma -- Pleomorphic xanthoastrocytoma -- Desmoplastic infantile ganglioglioma -- Dysembryoplastic neuroepithelial tumor of the pellucidum (DNET SP) -- CNS langerhans cell histiocytosis -- Hemangioma of infancy -- Vascular lesion of the face -- Retinoblastoma -- Tuberous sclerosis -- Neurofibromatosis type 1 -- Non-tumoral neurology [cases]: Acute disseminated encephalomyelitis -- Multiple sclerosis -- Posterior reversible encephalopathy syndrome -- Focal cortical dysplasia -- CNS takayasu arteritis -- Premamilar ventriculostomy -- Bilateral cystic microphthalmia (Bilateral cystic eye) -- Tuberculous meningitis -- Spinal epidural abscess -- Mitochondrial myopathy, encephalopathy, lactic acidosis, and stoke (MELAS) syndrome -- Thorax [cases]: Parapneumonic pleural effusion -- Primary pulmonary tuberculosis -- Viral infections -- Pulmonary aspergillosis -- Cystic fibrosis -- Cystic pleuropulmonary blastoma -- Endobronchial tumor: mucoepidermoid carcinoma -- Pulmonary artery sling -- Partial anomalous pulmonary venous return -- Coarctation of the aorta -- Non-tumoral abdomen [cases]: Intussusception -- Hypertrophic pyloric stenosis -- Mesenteric lymphadenopathy in children -- Acute appendiciis -- Inflammatory bowel disease -- Pancreatic trauma -- Focal nodular hyperplasia -- Ascariasis -- Congenital imperforate hymen with hydrocolpos -- Intrauterine spermatic cord torsion -- Tumoral abdomen [cases]: Neuroblastoma -- Hepatoblastoma -- Infantile hemangioendothelioma of the liver -- Endodermal sinus tumors (Yolk sac tumors) -- Adrenocortical tumors -- Hodgkin's lymphoma -- Non-Hodgkin lymphoma -- Hepatosplenic candidiasis in acute lymphoblastic leukemia -- Cystic testicular teratoma -- Ovarian tumor (Yolk sac tumor) -- Genitourinary [cases]: Wilms' tumor -- Fetal rhabdomyomatous nephroblastoma -- Mesoblastic nephroma -- Malignant rhabdoid tumor of the kidney -- Megacystis-microcolon-intestinal hypoperistalsis -- Ossifying renal tumor of infancy -- Xanthogranulomatous pyelonephritis -- Ureteral duplications -- Renal trauma -- Renal candidiasis -- Musculoskeletal [cases]: Legg-calve-perthes disease -- Perisciatic pyomyositis -- Chronic recurrent multifocal osteomyelitis -- Spondylodiscitis -- Septic arthritis of the hip -- Lipoblastoma -- Osteosarcoma -- Ewing's sarcoma -- Lumbar Ewing's sarcoma -- Granulocytic sarcoma -- Neonatal [cases]: Surfactant deficiency disease -- Bronchogenic cyst -- Localized persistent pulmonary interstitial emphysema -- Posthemorrhagic hydrocephalus in the preterm infant -- Hypoxoic-ischemic encephalopathy -- Cerebral sinovenous thrombosis in neonates -- Disseminated cerebral candidiasis in preterm infants -- Necrotizing enterocolitis -- Midgut volvulus -- Portal calcification seondary to umbilical vein catheterization -- Fetal [cases]: Fetal open-lip schizencephaly -- Classic lissencephaly -- Fetal thyrocervical teratoma -- Congenital cystic andemoatoid malformation, type II -- Congenital diaphragmatic hernia -- Multicystic dysplasia of the kidney -- Fetal posterior urethral valves -- Fetal jejunal atresia -- Prune belly syndrome (Eagle-Barrett syndrome) -- Gastroschisis.
  • 2008Click LINK above for Print location/circulation status.
    2008From: ProQuest Safari
    Randal L. Schwartz, Tom Phoenix, and Brian D. Foy.
  • 2007From: ProQuest Safari
    by Michele E. Davis and Jon A. Phillips.
  • 2007From: ProQuest Safari
    Mark Lutz.
  • 2016From: ClinicalKey
    William Herring, MD, FACR, Vice Chairman and Residency Program Director, Albert Einstein Medical Center, Philadelphia, Pennsylvania.
  • Simon St. Laurent and Edd Dumbill.
  • 2007From: ProQuest Safari
    Michael Fitzgerald.
  • Dale H. Schunk.
    "An essential resource for understanding the main principles, concepts, and research findings of key learning theories -especially as they relate to education-this proven text blends theory, research, and applications throughout, providing its readers with a coherent and unified perspective on learning in educational settings."--Publisher's description.
  • 2015From: Springer
    Jeffrey L. Houpt, Roderick W. Gilkey, Susan H. Ehringhaus.
  • [edited by] Francis A. Neelon, E. Harvey Estes, Andrew G. Wallace.
    PrintStatus: Not Checked OutLane Catalog Record
    Passing on the Stead legacy / Andrew G. Wallace -- The patient is the focus of doctoring / Francis A. Neelon -- Learning is a community affair / E. Harvey Estes -- We learn most when we ourselves teach / Earl N. Metz -- Thinking trumps memorization : the lesson on attending rounds? / Joseph C. Greenfield, Jr. -- Brain sorting in the 21st century / Galen S. Wagner -- Teachers of medicine and their students / Harold R. Silberman -- Summing up the symposium / Francis A. Neelon, E. Harvey Estes, Andrew G. Wallace.
  • 2012From: Springer
    Jose Luís del Cura, Pedro Seguí, Carlos Nicolau (editors).
    Abdominal ultrasound / Carlos Nicolau, Pedro Seguí, Jose Luís del Cura, Blanca Paño -- Woman's imaging / Jose Luís del Cura, Pedro Seguí, Rosa Zabala, Martín Velasco -- Musculoskeletal ultrasound / Angel Bueno, Jose Martel, Ana Sanz -- Small parts / Pedro Seguí, Elena Elizagaray, Carlos Nicolau -- Thorax / Rosa Zabala, Jose Luís del Cura -- Pediatrics / Fermín Sáez, Elena Elizagaray, José Martel -- Vascular / Blanca Paño, Pedro Seguí -- Contrast ultrasound / Teresa Fontanilla, Carlos Nicolau, Javier Minaya -- Interventional ultrasound / Jose Luís del Cura, Rosa Zabala, Igone Korta.
  • 2010From: Springer
    by José J. Muñoz and Ramón Ribes.
    This book is an introduction to interventional radiology. Written in a case-based format, the book is subdivided into ten chapters made up of ten vascular and non-vascular interventional radiology cases. Each case contains illustrations and legends describing the imaging findings and technical details of each intervention, comments from anatomical, physiopathological and radiological standpoints, as well as a description of the interventional procedure and the required interventional devices. The book is aimed at vascular and non-vascular interventional radiologists, vascular surgeons, radiology.
  • Aaron Reed.
  • 1922-From: Google Books
    par M. Loeper.
    Also available: Print – 1922-
  • 2014From: Springer Protocols
    edited by Jun Hirabayashi.
  • Huon H. Gray, Keith D. Dawkins, John M. Morgan, Iain A. Simpson ; with a foreword by A. John Camm.
    PrintStatus: Not Checked OutLane Catalog Record
    Taking a cardiovascular history -- Examination of the cardiovascular system -- The electrocardiogram -- Imaging -- Hypertension -- Coronary heart disease -- Thrombosis in cardiovascular disease -- The myocardium -- Heart failure -- Valvular heart disease -- The endocardium -- The pericardium -- Electrophysiology -- Cardiopulmonary resuscitation -- Diseases of the aorta -- Pulmonary hypertension and pulmonary thromboembolism -- Pregnancy and the heart -- Congenital heart disease -- Heart disease in the elderly -- Cardiac tumours -- Surgery and anaesthesia -- Cardiology, the law and occupation.
  • Carl L. Gwinnutt.
    PrintStatus: Not Checked OutLane Catalog Record
    Assessment and preparation for surgery -- The principles of anaesthesia -- The practice of anaesthesia -- Postanaesthesia care -- Recognition and management of the acutely ill patient on the ward -- Management of the critically ill patient.
  • Robin Graham-Brown, Tony Burns.
    PrintStatus: Not Checked OutLane Catalog Record
    Structure and function of the skin, hair and nails -- Approach to the diagnosis of dermatological disease -- Bacterial and viral infections -- Fungal infections -- Ectoparasite infections -- Acne, acneiform eruptions and rosacea -- Eczema -- Psoriasis -- Benign and malignant skin tumours -- Naevi -- Inherited disorders -- Pigmentary disorders -- Disorders of the hair and nails -- Bullous disorders -- Miscellaneous erythematous and papulosquamous disorders and light-induced skin diseases -- Vascular disorders -- Connective tissue disorders -- Pruritus -- Systemic disease and the skin -- Skin and the psyche -- Cutaneous drug reactions -- Treatment of skin disease.
  • 2014From: ProQuest Ebook Central
    Ray Clarke.
    "In Diseases of the Ear, Nose and Throat Lecture Notes, 11th edition you will find everything on the topic that could crop up in a clinic or teaching session. This little gem of a book is clearly laid out with colour photographs and illustrations, is broken down into intuitive chapters and sections, and contains treatment boxes, all of which help those key concepts stick"--Provided by publisher.
  • Peter Bull, Ray Clarke.
    PrintStatus: Not Checked OutLane Catalog Record
  • authored by, N.C. Hughes-Jones, S.N. Wickramasinghe, C.S.R. Hatton.
    PrintStatus: Not Checked OutLane Catalog Record
    Normal haemoglobin, blood cells, and haemopoiesis -- Anaemia and polycythaemia: general considerations -- Haemolytic anaemias -- Iron metabolism, iron deficiency anaemia, other hypochromic microcytic anaemias, and iron overload -- Macrocytosis and macrocytic anaemia -- Conditions causing white cell abnormalities -- Structure and function of lymphoid tissue -- Lymphomas: general principles -- Classification of lymphoma -- Hodgkin's lymphoma and some of the commoner clinical entities of non-Hodgkin's lymphomas, including ALL and CLL -- Myeloma and other paraproteinaemias -- Neoplastic disorders of myeloid cells -- Bone marrow transplantation -- Aplastic anaemia and pure red cell aplasia -- Haemostasis, abnormal bleeding, and anticoagulant therapy -- Blood transfusion and haemolytic disease of the newborn -- Basic haematological techniques and reference ranges.
  • edited by Ole H. Petersen.
    PrintStatus: Not Checked OutLane Catalog Record
    Cell physiology -- Cellular communication -- Introduction to the nervous system -- Signalling in the nervous system -- Muscle -- Sensory systems -- Special senses -- Motor system -- Higher nervous functions -- Pain -- Endocrine system -- Reproduction -- Blood -- Introduction to the cardiovascular system -- Cardiovascular system--the heart -- Vascular system -- Cardiovascular regulation, regional circulation and circulatory adjustments -- Respiration -- Digestive system -- Kidney -- Fluid and electrolyte balance -- Energy metabolism -- Temperature regulation -- Exercise.
  • Tom Elliott, Tony Worthington, Husam Osman, Martin Gill.
    PrintStatus: Not Checked OutLane Catalog Record
    Basic bacteriology : structure -- Basic bacteriology : physiology -- Basic bacteriology : genetics -- Classification of bacteria -- Staphylococci -- Streptococci and enterococcci -- Clostridia -- Other gram-positive bacteria -- Gram-negative cocci -- Enterobacteriaceae -- Parvobacteri -- Pseudomonas and other aerobic gram-negative bacilli -- Campylobacter, helicobacter, and vibrios -- Treponema, borrelia, and leptospira -- Gram-negative anaerobic bacteria -- Mycobacteria -- Chlamydiae, rickettsiaceae, mycoplasma -- Basic virology -- Major virus groups -- Basic mycology and classification of fungi -- Parasitology : protozoa -- Parasitology : metazoa (helminths) -- Host-parasite relationships -- Diagnostic laboratory methods -- Epidemiology and prevention of infection -- Management of infections -- Immunisation -- Sterilisation and disinfection -- Antibacterial agents -- Antifungal agents -- Antiviral agents -- Upper respiratory tract infections -- Lower respiratory tract infections -- Gastrointestinal infections -- Liver and biliary tract infections -- Urinary tract infections -- Genital infections (including sexually transmitted diseases) -- Infections of central nervous system -- Septicaemia and bacteraemia -- Device-related infections -- Drug-resistant microorganisms -- Cardiovascular infections -- Bone and joint infections -- Skin and soft-tissue infections -- Infections in the compromised host -- Perinatal and congenital infections -- Human immunodeficiency viruses -- Miscellaneous viral infections.
  • Lionel Ginsberg.
    PrintStatus: Not Checked OutLane Catalog Record
    Neurological history-taking -- Consciousness -- Cognitive function -- Vision and other cranial nerves -- Motor function -- Sensation -- Autonomic function -- Investigating the patient -- Headache and facial pain -- Epilepsy -- Stroke -- Parkinson's disease and other movement disorders -- Neurosurgical topics : head injury and brain tumour -- Neurological infections -- Spinal conditions -- Multiple sclerosis -- Nerve and muscle -- Development and degeneration -- Neurology and other medical specialties -- Neurological emergencies -- Neurorehabilitation.
  • Diana Hamilton-Fairley.
    PrintStatus: Not Checked OutLane Catalog Record
    Basic science -- The woman as a patient -- Puberty and menstrual problems of young women -- Subfertility -- Pregnancy prevention -- Benign diseases, genital tract infections and sexual problems -- The mother and fetus in pregnancy -- Bleeding in pregnancy -- The antenatal period -- Diseases of pregnancy -- Diseases in pregnancy -- Normal labour -- Abnormal labour -- Puerperium -- The newborn -- Abnormal vaginal blood loss -- Pelvic pain -- Breast disease -- Screening for gynaecological cancer -- Malignant gynaecological conditions -- The menopause -- Pelvic floor disorders -- Statistics of reproductive medicine.
  • Bruce James, Chris Chew, Anthony Bron.
    PrintStatus: Not Checked OutLane Catalog Record
    Anatomy -- History and examination -- Clinical optics -- The orbit -- The eyelids -- The lacrimal system -- Conjuctiva, cornea and sclera -- The lens and cataract -- Uveitis -- Glaucoma -- Retina and choroid -- Retinal vascular disease --The pupil and its responses -- The visual pathway -- Eye movements and their disorders -- Trauma -- Tropical ophthalmology : eye diseases in the developing world -- Symptoms of eye disease -- Services for the visually handicapped -- Clinical cases -- Useful references.
  • T. Duckworth, C.M. Blundell.
    PrintStatus: Not Checked OutLane Catalog Record
    Musculoskeletal structures and function -- Soft tissue injuries and healing -- Nerve injuries and repair -- Fractures and healing -- Fractures : principles of management -- Complications of fractures -- Major trauma -- Congenital malformations -- Generalised orthopaedic conditions -- Inflammatory conditions -- Degenerative conditions -- Neoplastic conditions of bone and soft tissue -- Infections -- Metabolic diseases of bone -- Examination of the musculoskeletal system -- The forearm, wrist, and hand -- The elbow -- The shoulder and upper arm -- The spine -- The pelvis -- The hip and thigh -- The knee and lower leg -- The foot and ankle -- Orthopaedic techniques.
  • Pradip R. Patel.
    PrintStatus: Not Checked OutLane Catalog Record
    Respiratory tract -- Cardiovascular system -- Gastrointestinal tract -- Liver and pancreas -- Urinary tract -- Musculoskeletal system -- Trauma -- Paediatrics -- Obstetrics and gynaecology -- Neuroradiology -- Specific radiological investigations -- Film-viewing hints.
  • 2015From: Springer
    Gab Kovacs, Paula Briggs.
    Part 1. Introduction -- 1. Basic Physiology- The Menstrual Cycle -- 2. Basic Embryology- The Development of the Foetus -- 3. Basic Genetics for the Obstetrician -- 4. The Gynaecological History and Examination -- 5. The Obstetric History and Examination.- Part 2: Gynaecology -- 6. An Outline of How to Think About Each Gynaecological Syndrome -- 7. Abnormal Vaginal Bleeding (AUB) -- 8. Endometriosis.- 9. Perlvic Organ Prolapse (POP).- 10. Urinary problems -- 11. Gynaecological Cancers- 12. Ovarian Cysts -- 13. Fibroids- Fibroleiomyomata -- 14. Termination of Pregnancy (TOP) -- 15. Contraception -- 16. Subfertility -- 17. Polycystic Ovaries (PCO) and Polycystic Ovarian Syndrome (PCOS) -- 18. Menopause -- 19. Psychosexual Problems.- Part 3: Obstetrics -- 20. Antenatal Care -- 21. The Labour -- 22. Multiple pregnancy -- 23. Malpresentation- 24. Early Pregnancy Loss and Ectopic Pregnancy -- 25. Antepartum Haemorrhage (APH) -- 26. Post Partum Haemorrhage (PPH) -- 27. Hypertension in Pregnancy, Gestational Hypertension, Pre Eclampsia, Eclampsia and HELLP Syndrome -- 28. Intrauterine growth restriction -- 29. Infections during pregnancy- Varicella, Herpes, Cytomegalovirus, Toxoplasma, Listeria, Group B Streptococcus -- 30. Endocrine Disease and Pregnancy- Thyroid Disorders and Diabetes -- 31. Medical Conditions- Cardiac Disease, Thrombophilias, Rhesus Immunisation -- 32. Postnatal Care.
  • edited by Andrus Viidik.
    PrintStatus: Not Checked OutLane Catalog Record
    v. 1, pt. A-B. On biology of ageing.
  • 2014From: Springer
    Fiona Roberts, Chee Koon Thum.
    Completely revised and updated, this well-illustrated and practically-oriented text has retained its general layout and style and division into specimen-type based chapters. The visual image remains key to explaining the pathological processes and this is facilitated by full colour photography throughout the text. The book emphasizes pertinent recent advances which augment the morphological study of disease. There is updated information on clinically important aspects, immunohistochemistry, tumour cytogenetics and molecular biology. Illustrations include macro specimens, microscopic specimens and illustrations of additional techniques - immunohistochemistry, molecular analyses and electron microscopy - to help both the pathologist and ophthalmologist understand the process that a specimen must go through prior to producing a report and how these various techniques help to refine the diagnosis. The third edition of Lee's Ophthalmic Histopathology is an invaluable reference source for ophthalmic pathologists, general pathologists and ophthalmologists.
  • 2016From: Springer
    Jacqueline Saw, Saibal Kar and Matthew J. Price, editors.
    This book provides a comprehensive overview of state-of-the-art left atrial appendage (LAA) closure, covering epidemiology of atrial fibrillation and stroke, LAA anatomy, surgical approaches, imaging for LAA closure, LAA closure procedure, and post-procedural management. LAA closure is a rapidly emerging field in stroke prevention for patients with atrial fibrillation. Several percutaneous and surgical devices are now available in many countries, including WATCHMAN, Amplatzer Cardiac Plug and Amulet, and LARIAT devices, and many more are in clinical development and are being evaluated in research trials. As LAA closure is a technically challenging procedure, detailed knowledge of the rationale, anatomy, and technical approach of this modality guides clinicians in patient selection and facilitates procedural success. Left Atrial Appendage Closure is a valuable resource for interventional cardiologists, electrophysiologists, echocardiographers, radiographers, fellows, and residents in guiding the management of patients prior to, during, and following LAA closure. .
  • 2009From: Springer
    Corrado Tamburino ; in collaboration with Maria Elena Di Salvo, Alessio La Manna, Davide Capodanno.
  • 2007From: Springer
    M.L. López-Gracia and M.A. Ros.
  • 2008From: Springer
    Jesper Hoffmeyer, editor.
    Introduction: Bateson the precursor / Jesper Hoffmeyer -- Angels fear revisited: Gregory Bateson's cybernetic theory of mind applied to religion-science debates / Mary Catherine Bateson -- From thing to relation. On Bateson's bioanthropology / Jesper Hoffmeyer -- What connects the map to the territory? / Tyrone Cashman -- The pattern which connects pleroma to creatura: the autocell bridge from physics to life / Terrence Deacon and Jeremy Sherman -- Bateson's method: double description. What is it? How does it work? What do we learn? / Julie Hui, Tyrone Cashman, and Terrence Deacon -- Gregory Bateson's relevance to current molecular biology / Luis Emilio Bruni -- Process ecology: creatura at large in an open universe / Robert E. Ulanowicz -- Connections in action - bridging implicit and explicit domains / Teresa S.S. Shilhab and Christian Gerlach -- Bateson: biology with meaning / Brian Goodwin -- Gregory Bateson's "uncovery" of ecological aesthetics / Peter Harries-Jones -- Collapsing the wave function of meaning: the epistemological matrix of talk-in-interaction / Donald Favareau -- Re-enchanting evolution: transcending fundamentalisms through a mythopoetic epistemology / Gregory Mengel -- Bateson and Peirce on the pattern that connects and the sacred / Søren Brier -- Bateson, Peirce and the sign of the sacred / Deborah Eicher-Catt.
  • 2007From: Thieme eNeurosurgery
    edited by Aaron A. Cohen-Gadol, Dennis D. Spencer.
    Pituitary tumors and other parasellar region masses -- Gliomas and other "malignant" tumors -- Meningiomas -- Cerebral aneurysms and arteriovenous malformations -- Spinal tumors -- Posterior fossa tumors and other pathologies -- Special illustrations, additional operative sketches, teaching slides, and operating room photographs.
  • 2016From: Oxford Medicine Online
    edited by Nessa Coyle, PhD, APRN, FAAN ; consultant Palliative Care and Clinical Ethics in Oncology, New York, New York.
    Ethical considerations in palliative care / Maryjo Prince-Paul and Barbara J. Daly -- Palliative care and requests for assistance in dying / Deborah L. Volker -- Artificial nutrition and hydration / Michelle S. Gabriel and Jennifer A. Tschanz -- End-of-life care for patients with medical illness and personality disorders / Betty D. Morgan -- Poor, homeless and underserved populations / Anne Hughes -- Self-assessment test questions / Nessa Coyle.
  • American College of Legal Medicine Textbook Committee ; S. Sandy Sanbar, editor ; Marvin H. Firestone, deputy editor ; Sal Fiscina ... [et al.] past president.
    PrintStatus: Not Checked OutLane Catalog Record
  • edited by Max Borten and Emanuel A. Friedman.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2013From: Springer Protocols
    edited by Carmen Buchrieser, Hubert Hilbi.
    Identification of Legionella in the environment / Natalia A. Kozak, Claressa E. Lucas, and Jonas M. Winchell -- Identification of Legionella in clinical samples / Sophie Jarraud [and others] -- Sequence-based identification of Legionella / Rodney M. Ratcliff -- Investigation of outbreaks : epidemiology / Carol Joseph -- Outbreak investigations and identification of Legionella in contaminated water / Susanne Lee and John Lee -- Typing methods for Legionella / Christian Lück [and others] -- Culturing, media, and handling of Legionella / Christa H. Chatfield and Nicholas P. Cianciotto -- Intracellular metabolism of Legionella by isotopologue profiling / Klaus Heuner and Wolfgang Eisenreich -- Induction of competence for natural transformation in Legionella pneumophila and exploitation for mutant construction / Carmen Buchrieser and Xavier Charpentier -- Constructing unmarked gene deletions in Legionella pneumophila / Andrew Bryan, Zachary D. Abbott, and Michele S. Swanson -- Natural biofilm formation with Legionella pneumophila / Emilie Portier and Yann Hechard -- Production of L. pneumophila monospecies biofilms in a low-nutrient-concentration medium / Sophie Pécastaings and Christine Roques -- Enrichment of outer membrane vesicles shed by Legionella pneumophila / Jens Jäger and Michael Steinert -- Analysis of Legionella infection by flow cytometry / André N. Tiaden, Aline Kessler, and Hubert Hilbi -- Analysis of Legionella infection using RNAi in Drosophila cells / Dennise A. De Jesús, Tamara J. O'Connor, and Ralph R. Isberg -- Immunofluorescence imaging of Legionella infection in vitro / Stefan S. Weber and Annette Oxenius -- Electron microscopy of Legionella and Legionella-infected cells / Gary Faulkner and Rafael A. Garduño -- Pathogen vacuole purification from Legionella-infected amoeba and macrophages / Christine Hoffmann, Ivo Finsel, and Hubert Hilbi -- Methods for determining protein translocation by the Legionella pneumophila Dot/Icm type IV secretion system / Wenhan Zhu and Zhao-Qing Luo -- Subcellular localization of Legionella Dot/Icm effectors / Adam J. Vogrin [and others] -- Purification and characterization of Legionella U-box-type E3 ubiquitin ligase / Hiroki Nagai and Tomoko Kubori -- Legionella phospholipases implicated in infection : determination of enzymatic activities / Kathleen Seipel and Antje Flieger -- Interactions of Legionella effector proteins with host phosphoinositide lipids / Stephen Weber, Stephanie Dolinsky, and Hubert Hilbi -- Characterization of Legionella lipopolysaccharide / Christian Lück and Jürgen H. Helbig -- Tetrahymena and acanthamoeba model system / Sharon G. Berk and Rafael A. Garduño -- Dictyostelium host response to Legionella infection : strategies and assays / Salvatore Bozzaro, Barbara Peracino, and Ludwig Eichinger -- Caenorhabditis elegans model of Legionella infection / Ann Karen C. Brassinga and Costi D. Sifri -- Infection of nonphagocytic host cells by Legionella / Shandra R. Day, Costi D. Sifri, and Paul S. Hoffman -- Analyzing caspase-1 activation during Legionella pneumophila infection in macrophages / Christopher L. Case and Craig R. Roy -- Mouse as a model for pulmonary Legionella infection / Juliana I. Hori and Dario S. Zamboni -- Assessment of Legionella-specific immunity in mice / Stefan S. Weber, Nicole Joller, and Annette Oxenius -- Guinea pig model of legionnaires' disease / Paul H. Edelstein -- Human susceptibility to legionnaires' disease / William R. Berrington and Thomas R. Hawn -- cDNA library construction for next-generation sequencing to determine the transcriptional landscape of Legionella pneumophila / Tobias Sahr and Carmen Buchrieser -- Methods to study Legionella transcriptome in vitro and in vivo / Sebastien P. Faucher and Howard A. Shuman -- Co-immunoprecipitation : protein-RNA and protein-DNA interaction / Tobias Sahr and Carmen Buchrieser -- Identification of Legionella effectors using bioinformatic approaches / Gil Segal.
  • edited by Jamie Bartram ... [et al.].
    PrintStatus: Not Checked OutLane Catalog Record
  • 2008From: Springer
    Paul Hoffman, Herman Friedman, Mauro Bendinelli.
  • 2013From: Springer Protocols
    edited by Ray J. Rose.
    Featuring current resources used to discover new legume family genes and to understand genes and their interactions, Legume Genomics: Methods and Protocols provides techniques from expert researchers to study these plants that are so vitally important for food, feed, human nutrition, bioenergy, and industrial purposes. This detailed volume covers genome characterization and analysis, transcriptome analysis and miRNA identification/analysis, forward and reverse genetics, molecular markers, as well as transformation strategies used to investigate gene function and many other topics. Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Authoritative and useful, Legume Genomics: Methods and Protocols aims to serve plant molecular biologists, molecular breeders, plant physiologists and biochemists, developmental biologists, and those interested in plant-microbe interactions.
  • dargestellt unter Bevorzugung funktioneller Zusammenhänge ; begründet von Alfred Benninghoff ; hrsg. und bearb. von Kurt Goerttler.
    PrintStatus: Not Checked OutLane Catalog Record
    Bd. 1. Allgemeine Anatomie und Bewegungsapparat -- Bd. 2. Eingeweide -- Bd. 3. Nervensystem, Haut und Sinnesorgane.
  • 1864-From: Google Books
    Zeissl, H.
    Also available: Print – 1864-
  • Schaltenbrand, Georges.
    PrintStatus: Not Checked OutLane Catalog Record
    [T. 3] Die Nervenkrankheiten.
  • 1880-From: Google Books
    Landois, L.; Rosemann, Hans, Ulrich; Rosemann, R.
    Also available: Print – 1885.
  • 1880-From: Google Books
    Landois, L.; Rosemann, Hans Ulrich; Rosemann, R.
    Also available: Print – 1887.
  • von Eduard Kaufmann.
    PrintStatus: Not Checked OutLane Catalog Record
    2. Bd., 1. T., 1. Lfg. Knochen, Gelenke, Muskeln, Sehnen, Sehnenscheiden, Schleimbeutel. Anhang: Literaturangaben -- 2. Bd., 1. T., 2. Lfg. Geschlechtsorgane. Anhang: Literaturangaben -- 2. Bd., 1. T., 3. Lfg. Harnorgane (Niere und ableitende Harnwege einschliesslich Harnröhre).
  • 1913-From: Google Books
    von S. Jessner.
    1. Bd. Hautleiden und Kosmetik (xvi, 391 p., 31 col. plates) -- 2. Bd. Geschlechtsleiden (viii, 344 p., 22 col. plates). 1. Bd. Hautleiden und Kosmetik.
    Also available: Print – v. 1-2.
  • von Dr. Alfred Vogt ...
    PrintStatus: Not Checked OutLane Catalog Record
  • 1907-From: Google Books
    von Jacob Wolff.
    Also available: Print – 1907-
  • 2010From: ClinicalKey
    [edited by] Richard T. Hoppe, Theodore Locke Phillips, Mack Roach, III.
    Section I. Radiation biology and physics -- Section II. Imaging -- Section III. Radiation oncology -- Part 1. Central nervous system -- Part 2. Head and neck tumors -- Part 3. Tumors of the thorax -- Part 4. Gastrointestinal tumors -- Part 5. Urologic tumors -- Part 6. Gynecologic tumors -- Part 7. Pediatric tumors -- Part 8. Cancer of the breast -- Part 9. Adult sarcomas -- Part 10. Lymphomas -- Part 11. Ocular cancer -- Part 12. Skin cancer -- Part 13. Benign disease -- Section IV. Emerging radiation modalities.
    Also available: Print – 2010
  • 2013From: Springer
    Awanish Kumar.
    Leishmania-related illnesses remain among the world s deadliest neglected tropical diseases, affecting approximately 12 million people in 88 countries. The mortality rate is substantial, contributing to nearly two million disability-adjusted life years. As more is understood about this parasite and its effects, work toward prevention, control, and treatment continues apace. Leishmania and Leishmaniasis will address the parasite and its attendant disease, which manifests in three syndromes: Visceral (VL), Cutaneous (CL) and Mucocutaneous Leishmaniasis (ML). The morphology and life cycles of the various species will be among the topics addressed in Part One. Part Two will focus on immunology, including host-immune response to Leishmania infection, cross-immunity between the different species and adoptive transfer of immunity. Parts Three and Four will address how Leishmania invade and survive, the clinical features of the disease, and its diagnosis. Drugs, vaccines and treatment will be thoroughly explored, including experimental models of therapeutics. Leishmania and Leishmaniasis will provide a thorough examination of a parasite, the illnesses it causes and the misery it continues to visit upon large segments of the population.
  • 2006From: Springer
    ed. by Lisa Gould and Michelle L. Sauther.
    Lemur origins, history of ecological studies on lemurs, and the ecology of the recently extinct (subfossil) lemurs -- Origin of the Malagasy strepsirhine primates / Ian Tattersall -- Notes on the history of ecological studies of Malagasy lemurs / Alison Jolly and R.W. Sussman -- Ecology and extinction of Madagascar's subfossil lemurs / Laurie R. Godfrey, William L. Jungers, and Gary T. Schwartz -- The evolution of lemur traits, basic and unusual patterns -- Impact of ecology on the teeth of extant lemurs : a review of dental adaptations, function, and life history / Frank P. Cuozzo and Nayuta Yamashita -- Big is beautiful : fat storage and hibernation as a strategy to cope with marked seasonality in the fat-tailed dwarf lemur (Cheirogaleus medius) / Joanna Fietz and K.H. Dausmann -- Polyspecific associations of crowned lemurs and Sanford's lemurs in Madagascar / Benjamin Z. Freed -- Cathemerality in lemurs / Deborah J. Curtis -- Adaptations in the aye-aye : a review / Eleanor J. Sterling and Erin E. McCreless -- Connecting ecology and adaptation : summaries and new studies -- Evolutionary divergence in the brown lemur species complex / Steig E. Johnson -- Ecological diversity and seasonal adaptations of mouse lemurs (Microcebus spp.) / Ute Radespiel -- Social pair-bonding and resource defense in wild red-bellied lemurs (Eulemur rubriventer) / Deborah J. Overdorff and Stacey R. Tecot -- Lemur catta ecology : what we know and what we need to know / Lisa Gould -- Impact of seasonality and reproduction on social structure, ranging patterns, and fission-fusion social organization in red ruffed lemurs / Natalie Vasey -- Ecologically enigmatic lemurs : the sifakas of the eastern forests (Propithecus candidus, P. diadema, P. edwardsi, P. perrieri, P. tattersalli) / Mitchell T. Irwin -- Behavioral and ecological adaptations in two small folivorous lemurs with different social organization : Avahi and Lepilemur / Urs Thalmann -- The feeding ecology and related adaptations of Indri indri / Joyce A. Powzyk and Christopher B. Mowry -- Behavior and ecology of gentle lemurs (genus Hapalemur) / Chia L. Tan -- Lemur adaptations to a changing environment, natural and anthropogenic stress -- Considering climate change effects in lemur ecology and conservation / Patricia C. Wright -- Diet composition, foraging, and feeding behavior in relation to habitat disturbance : implications for the adaptability of ruffed lemurs (Varecia variegata editorium) in Manombo Forest, Madagascar / Jonah Ratsimbazafy -- Overview on the health and disease ecology of wild lemurs : conservation implications / Randall E. Junge and Michelle L. Sauther
  • 2014From: Springer
    edited by Shizuya Saika, Liliana Werner, Frank J. Lovicu.
    This book is the first to summarize the current knowledge of the cell biology of lens epithelial cells in relation to and in the development of posterior capsular opacification (PCO). PCO remains the most common long-term complication of modern cataract surgery, occurring months or years after cataract surgery, unlike most other complications that tend to arise during or soon after the procedure. Opacification of the posterior capsule appears to be linked to lens epithelial cells that are left behind in the eye during cataract removal. These cells proliferate, migrate across the posterior lens capsule, and undergo changes that result in fibrous or pearl-type opacities in the capsule. The first section of the text explains the molecular mechanism and biology of lens epithelial cells that lead to the incidence of PCO. In the second part, in addition to a description of the mechanism and pathological condition of PCO, surgical methods and devices for preventing PCO are discussed in detail. Lens Epithelium and Capsular Opacification will benefit not only young clinical residents and junior researchers, but also established faculty in the clinical or basic academic field.
  • 2007From: Springer
    edited by Shayam S. Yadav, David L. McNeil and Philip C. Stevenson.
  • 2012From: Springer
    by David Escors, Karine Breckpot, Frederick Arce, Grazyna Kochan, Holly Stephenson.
    Annotation Gene therapy was conceived during the early and mid part of the 20th century. At first, it was considered a revolutionary biomedical procedure, which could potentially cure any disease for which the molecular bases were understood. Since then, gene therapy has gone through many stages and has evolved from a nearly unrealistic perspective to a real life application. Clinical efficacy in humans was demonstrated at the beginning of this century after its successful application in small-scale clinical trials to cure severe immunodeficiency in children. However, their successes were overshadowed some time later by the occurrence of vector-related leukaemia in a number of treated children. It is in this context that lentiviral vectors have appeared, with improved efficiency and, possibly, increased biosafety. Very recently, the first clinical trials with lentivectors have been carried out with some success. This Brief firstly defines gene therapy, and places lentivectors within this fascinating therapeutic strategy. Then follows a comprehensive description of the development of retroviral and lentiviral vectors and how to specifically target distinct cell types and tissues. The authors also discuss the application of lentivector gene therapy for the treatment of cancer and autoimmune diseases, ending with the application of lentivectors in human gene therapy clinical trials.
  • 2016From: Cambridge
    edited by Runjan Chetty, the Laboratory Medicine Program, University Health Network, Toronto, Ontario, Canada, Kumarasen Cooper, University of Pennsylvania Hospital, Philadelphia, PA, USA, Allen Gown, PhenoPath Laboratories, Seattle, WA, and University of British Columbia, Vancouver, BC, Canada.
    "Providing a unique A-Z guide to antibodies for immunohistology, this is an indispensable source for pathologists to ensure the correct application of immunohistochemistry in daily practice. Each entry includes commercial sources, clones, descriptions of stained proteins/epitopes, the full staining spectrum of normal and tumor tissues, staining pattern and cellular localization, the range of conditions of immunoreactivity, and pitfalls of the antibody's immunoprofile, giving pathologists a truly thorough quick-reference guide to sources, preparation and applications of specific antibodies. Appendices provide useful quick-reference tables of antibody panels for differential diagnoses, as well as summaries of diagnostic applications. Expanded from previous editions with over forty new entries, this handbook for diagnostic, therapeutic, prognostic and research applications of antibodies is an essential desktop book for practicing pathologists as well as researchers, residents and trainees"-- Provided by publisher.
  • 2012From: Springer
    Enrico Nunzi, Cesare Massone, editors.
    Part 1. GENERAL SECTION / History and Phylogeography of Leprosy / Stewart T. Cole and Pushpendra Singh -- Microbiology / Andrea Clapasson and Silvia Canata -- Genetics of Leprosy / Vinicius Medeiros Fava and Marcelo Távora Mira -- Host Response to M. leprae / Rodrigo Ribeiro-Rodrigues -- Pathogenesis / Cesare Massone and Enrico Nunzi -- Classification / Cesare Massone and Alexandra M. G. Brunasso -- Part 2. PATIENT'S EXAMINATION -- Patient History / Enrico Nunzi, Cesare Massone and Salvatore Noto -- Laboratory Investigations / Andrea Clapasson and Silvia Canata -- Part 3. SKIN -- Physical Examination: Skin / Enrico Nunzi, Cesare Massone and Salvatore Noto -- Clinical Features / Enrico Nunzi, Cesare Massone and Salvatore Noto -- Lucio-Latapí Leprosy / Mario Magaña -- Histopathology of the Skin / Cesare Massone -- Differential Diagnosis: Skin / Enrico Nunzi and Salvatore Noto -- Part 4. NERVES -- Peripheral Nerves in Leprosy / Bernard Naafs and José Antônio Garbino -- The Leprosy Neuropathy / Lizia Reni, Salvatore Noto and Pieter A. M. Schreuder -- Primary Neural Leprosy / José Antônio Garbino and Bernard Naafs -- Chronic Neuropathic Pain in Leprosy / José Antônio Garbino, Bernard Naafs and Pedro Schestatsky -- Electrodiagnostic Studies / Lizia Reni -- Imaging / Carlo Martinoli, Leila Oppezzi and Alberto Tagliafico -- Differential Diagnosis: Nerves / Lizia Reni -- Part 5. Reactions in Leprosy / Reactions in Leprosy / Bernard Naafs and Salvatore Noto -- Lucio's Phenomenon / Mario Magaña -- Part 6. SYSTEMIC INVOLVEMENT -- Ocular Involvement in Leprosy / Susan Lewallen and Paul Courtright -- Otolaryngological Manifestations of Leprosy / Sinésio Talhari, Camila Bandeira de Oliveira and Carolina Talhari -- Other Organs / Enrico Nunzi and Salvatore Noto -- Part 7. PATIENT'S MANAGEMENT -- Diagnostic Work-Up / Enrico Nunzi, Cesare Massone and Salvatore Noto -- Drugs in Leprosy / Sinésio Talhari and Mahreen Ameen -- Treatment and Prophylaxis / Pierre Bobin -- Prognosis / Enrico Nunzi -- Neurolysis / Sergio S. G. Gennaro -- Prevention of Disability and Ulcer Care / J. Wim Brandsma and Hugh Cross -- Surgical and Social Rehabilitation / J. Wim Brandsma and Sunil Deepak -- Part 8. LEPROSY AND COMMUNITY -- Leprosy in Pregnancy / Elizabeth Duncan -- Leprosy and HIV/AIDS Co-infection / Sinésio Talhari and Carolina Talhari -- Epidemiology of Leprosy / Salvatore Noto and Pieter A. M. Schreuder -- Leprosy Control / Sunil Deepak and Giovanni Gazzoli -- Teledermatology / Cesare Massone and Antonio Pedro Mendes Schettini -- The Leprosy Mailing List / Salvatore Noto.
  • Angela Ki Che Leung.
    "Angela Ki Che Leung's meticulous study begins with the classical annals of the imperial era, which contain the first descriptions of a feared and stigmatized disorder modern researchers now identify as leprosy. She then tracks the relationship between the disease and China's social and political spheres (theories of contagion prompted community and statewide efforts at segregation); religious traditions (Buddhism and Daoism ascribed redemptive meaning to those suffering from the disease), and evolving medical discourse (Chinese doctors have contested the disease's etiology for centuries). Leprosy even pops up in Chinese folklore, attributing the spread of the contagion to contact with immoral women." "Leung next places the history of leprosy into a global context of colonialism, racial politics, and "imperial danger." A perceived global pandemic in the late nineteenth century seemed to confirm Westerners' fears that Chinese immigration threatened public health. Therefore battling to contain, if not eliminate, the disease became a central mission of the modernizing, state-building projects of the late Qing empire, the nationalist government of the first half of the twentieth century, and the People's Republic of China." "Stamping out the curse of leprosy was the first step toward achieving "hygienic modernity" and erasing the cultural and economic backwardness associated with the disease. Leung's final move connects China's experience with leprosy to a larger history of public health and biomedical regimes of power, exploring the cultural and political implications of China's Sino-Western approach to the disease."--Jacket.
  • 2006From: Springer
    edited by V. Daniel Castracane, Michael C. Henson.
  • 2015From: Springer
    Sam Dagogo-Jack, editor ; contributors Denis G. Baskin [and forty one others].
    Twenty years after its discovery, recombinant human leptin has been approved by the Food and Drug Administration for the treatment of patients with lipodystrophy. Beginning with a synthesis of the vast body of work on its discovery, dissection of mechanisms, and effects in experimental models , the focus of this book shifts to a consideration of the regulation and role of leptin in humans. The emphasis on human-level data is a unique feature of this book. The results of numerous studies indicate that leptin is indeed a regulated human hormone. Leptin provides a detailed account of the myriad physiological, hormonal, metabolic, immunological, mitogenic and inflammatory modulators and targets of leptin in a single volume. Next follows a comprehensive presentation of the therapeutic trials of recombinant leptin in patients with congenital leptin deficiency, lipodystrophy, hypothalamic amenorrhea, and other emerging areas, including leptin supplementation in leptin-replete subjects, leptin substitution for insulin in diabetic models, and novel combination regimens of leptin and other biogenic peptides. Unanswered questions and future directions in leptin research are highlighted in the Foreword by Dr. Jeffrey Friedman and throughout the volume. Identifying such questions helps direct research that could deepen understanding of the complex regulation of leptin under physiological and pathological conditions, a critical prerequisite to its rational deployment in the treatment of human disorders.
  • 2005From: Springer
    edited by Lauren E. Abrey, Marc C. Chamberlain, and Herbert H. Engelhard.
    Anatomy and physiology of the leptomeninges and CSF space / Neil Barshes, Alexis Demopoulos and Herbert H. Engelhard -- Leptomeningeal neoplasia: epidemiology, clinical presentation, CSF analysis and diagnostic imaging / Roelien H. Enting -- Leptomeningeal metastases from solid tumors (Meningeal carcinomatosis) / Michiko Kimura Bruno and Jeffrey Raizer -- Leptomeningeal metastases from leukemias and lymphomas / Craig P. Nolan and Lauren E. Abrey -- Leptomeningeal metastasis of primary central nervous system (CNS) neoplasms / Herbert H. Engelhard and Luke A. Corsten -- Leptomeningeal cancer in the pediatric patient / Kathleen A. Neville and Susan M. Blaney -- Neurosurgical interventions for leptomeningeal tumor / Jeffrey P. Greenfield and Mark H. Bilsky -- Current treatment of leptomeningeal metastases: systemic chemotherapy, intrathecal chemotherapy and symptom management / Stacey L. Berg and Marc C. Chamberlain -- Radiation therapy for leptomeningeal cancer / Minesh Mehta and Kristin Bradley -- Animal models of leptomeningeal cancer / Ali Raja and Herbert H. Engelhard -- Improving the outcome of patients with leptomeningeal cancer: new clinical trials and experimental therapies / Kurt Jaeckle.
    Also available: Print – 2005
  • 2015From: Springer
    Ben Adler, Editor.
    This volume covers all aspects of infection by pathogenic Leptospira species, the causative agents of the world?s most widespread zoonosis. Topics include aspects of human and animal leptospirosis as well as detailed analyses of our current knowledge of leptospiral structure and physiology, epidemiology, pathogenesis, genomics, immunity and vaccines. Updates are presented on leptospiral systematics, identification and diagnostics, as well as practical information on culture of Leptospira. Contact information is also provided for Leptospira reference centers. All chapters were written by experts in the field, providing an invaluable reference source for scientists, veterinarians, clinicians and all others with an interest in leptospirosis.
  • 2016From: Springer
    Kristen Eckstrand, Jesse M. Ehrenfeld, editors.
    Part I: The LGBT Population and Health -- 1. Understanding the LGBT Community -- 2. Access to Care -- 3. Culture, Climate, and Advocacy -- 4. Internalized Homophobia, Disclosure, and Health -- Part II: The LGBY-Inclusive Clinical Encounter -- 5. Clinic and Intake Forms -- 6. Medical History -- 7. Utilizing the Electronic Health Record as a Tool for Reducing LGBT Health Disparities -- Part III: LGBT Preventative Health and Screening -- 8. Primary Care, Prevention, and Coordination of Care -- 9. LGBT Parenting -- 10. Intimate Partner Violence -- Part IV: LGBT Health in Specialty Medicine -- 11. Pediatric and Adolescent LGBT Health -- 12. Geriatric Care and the LGBT Older Adult -- 13. Adult Mental Health -- 14. Sexually Transmitted Infections in LGBT Populations -- 15. Dermatology -- 16. Urologic Issues in LGBT Health -- 17. Obstetric and Gynecologic Care for Individuals Who Are Lesbian, Gay, Bisexual, and Transgender -- Part V: Transgender Health -- 18. Interdisciplinary Care of the Transgender Patient -- 19. Medical Transition for Transgender Individuals -- 20. Surgical Treatments for the Transgender Population -- 21. Facial Feminization Surgery: Review of Facial Analysis and Surgical Procedures -- Part VI: Emerging Topics in LGBT Medicine -- 22. Immigrant and International LGBT Health -- 23. Disorders of Sex Development / Intersex Populations -- 24. Legal and Policy Issues -- 25. Common LGBT Sexual Health Questions.
  • [edited by] Suzanne L. Dibble, Patricia A. Robertson.
    PrintStatus: Not Checked OutLane Catalog Record
    Health screening for lesbians / Audrey S. Koh -- Clinical care for lesbian adolescents / Elizabeth Lorde-Rollins -- Lesbians' sexual health / Jeanne M. Marrazzo -- Lesbian relationships / Esther D. Rothblum -- Fertility options for Lesbians / Paula Amato, Mary Casey Jacob -- Lesbians and pregnancy / Christy M. Isler, Leslie M. Cragin -- Children of lesbian parents / Mary Ann A. van Dam -- Smoking and lesbians / Michele J. Eliason, Laurie Drabble -- Patterns of alcohol and drug abuse among lesbians / Laurie Drabble, Michele J. Eliason, Migdalia Reyes -- Obesity in the lesbian community / Sarah C. Fogel -- Physical activity among lesbians / Danielle R. Brittain -- Back pain: the basics / Heather Rachel Davids -- Orthopedic issues for lesbians / Lesley J. Anderson, Lynn M. Forsey -- Unique aspects of benign gynecology for lesbians / Claire Herrick, Alison F. Jacoby -- Menopause and lesbians / Susan R. Johnson -- Lesbians and depression / Cynthia L. Benton, Ellen Haller -- Serious mental illness among lesbians / Mary E. Barber -- Lesbian intimate partner violence / Kelly A. Blasko -- Lesbians, violence, and health / Kimberly F. Balsam, Keren Lehavot -- Lesbians with diabetes / Dawn Marie Wadle, Corbett Joan O'Toole -- The impact of a cancer diagnosis on lesbians / Alicia K. Matthews -- Breast cancer among lesbians / Marion H.E. Kavanaugh-Lynch -- Lesbians and gynecologic malignancy / Katherine A. O'Hanlan -- Colon and rectal cancer among lesbians / Usha Menon, Lisa B. Weissmann -- Lesbians and infectious diseases / Donna DeFreitas, Nyonnoweh Greene -- Cardiovascular issues for lesbians / Pamela Charney, Dana P. McGlothlin -- Urinary incontinence among lesbians / Leah M. Kelley, Leslee L. Subak -- Osteoporosis among lesbians / Carolyn B. Becker -- Diabetes among lesbians / Cindy Ripsin, Patricia A. Robertson -- Palliative and hospice care for lesbians / Jane L. Appleby -- Old age in lesbian communities / Kelly Knochel, Jean K. Quam.
  • 2009From: Springer
    James L. Van Etten, editor.
    The Phycodnaviridae : The story of how tiny giants rule the world / W.H. Wilson, J.L. Etten and M.J. Allen -- African swine fever virus / E.R. Tulman [and others] -- Mimivirus / J.M. Claverie, C. Abergel and H. Ogata -- Family Iridoviridae : poor viral relations no longer / V.G. Chinchar [and others] -- Ascoviruses: Superb Manipulators of Apoptosis for Viral Replication and Transmission / B.A. Federici [and others] -- Whispovirus / J.H. Leu [and others] -- Jumbo bacteriophages / R.W. Hendrix.
    Also available: Print – 2009
  • 2008From: Springer
    Susan Schmerler.
    Sources of liability: Forms of legal complaints -- Duty as an element of a lawsuit: obligations and responsibilities -- Duty as an element of a lawsuit: sources of standards -- Duty as an element of a lawsuit: procedural requirments -- Breach, causation, and damages as elements of a lawsuit -- Defenses to a lawsuit -- Communication.
  • 2002From: NAP
    [Panel on IRBs, Surveys and Social Science Research, Cora Marrett, chair].
  • 2012From: Springer Protocols
    edited by Robert B. Ashman.
    ENU-based phenotype-driven screening / Vera M. Ripoll, Philip L. Kong, and Paul K. Potter -- Detection and quantification of cytokines and other biomarkers / Evan L. Chiswick ... [et al.] -- Flow cytometry analysis of cell cycling and proliferation in mouse hematopoietic stem and progenitor cells / Valérie Barbier ... [et al.] -- Flow cytometry measurement of bone marrow perfusion in the mouse and sorting of progenitors and stems cells according to position relative to blood flow in vivo / Valérie Barbier ... [et al.] -- Analyzing cell death events in cultured leukocytes / Karin Christenson, Fredrik B. Thorén, and Johan Bylund -- Towards a four-dimensional view of neutrophils / Ben A. Croker, Andrew W. Roberts, and Nicos A. Nicola -- Isolation of human and mouse neutrophils ex vivo and in vitro / Yan Hu -- Measurement of oxidative burst in neutrophils / Yu Chen and Wolfgang G. Junger -- Measurement of neutrophil elastase, proteinase 3, and cathepsin G activities using intramolecularly quenched fluorogenic substrates / Brice Korkmaz ... [et al.] -- The macrophage / Chris P. Verschoor, Alicja Puchta, and Dawn M.E. Bowdish -- Generation and characterization of MacGreen mice, the CFS1R-EGFP transgenic mice / R. Tedjo Sasmono and Elizabeth Williams -- Generation of mouse bone marrow-derived macrophages / Silvia Manzanero -- Isolation and differentiation of monocytes-macrophages from human blood / Dipti Vijayan -- In vitro measurement of phagocytosis and killing of Cryptococcus neoformans by macrophages / André Moraes Nicola and Arturo Casadevall -- Measuring the inflammasome / Olaf Gross -- Arginine and macrophage activation / Mònica Comalada -- Immunodetection of granzyme B tissue distribution and cellular localisation / Catherina H. Bird ... [et al.] -- Detection of human and mouse granzyme B activity in cell extracts / Sarah Elizabeth Stewart ... [et al.] -- T cell transfer model of colitis : a great tool to assess the contribution of T cells in chronic intestinal inflammation / Rajaraman Eri, Michael A. McGuckin, and Robert Wadley -- Measurement of nitrite in urine by gas chromatography-mass spectrometry / Dimitrios Tsikas ... [et al.].
  • 2003From: Wellcome Trust
    edited by D.A. Christie and E.M. Tansey.
  • Barbara J. Bain.
    PrintStatus: Not Checked OutLane Catalog Record
    The nature of leukaemia, cytology, cytochemistry and the FAB classification of acute leukaemia -- Immunophenotyping and cytogenetic/molecular genetic analysis in leukaemia and related conditions -- Acute leukaemia : integration of morphological, immunophenotypic, and genetic information and the WHO classification -- The myelodysplastic syndromes -- Chronic myeloid leukaemias -- Lymphoid leukaemias of mature T, B and natural killer cells.
  • 2009From: Springer Protocols
    edited by Chi Wai Eric So.
    An overview: from discovery of candidate mutations to disease modeling and transformation mechanisms of acute leukemia / C.W. So -- Backtracking of leukemic clones to birth / J. Wiemels, M. Kang and M. Greaves -- Fluorescence In situ hybridization (FISH) as a tool for the detection of significant chromosomal abnormalities in childhood leukaemia / Z.J. Konn ... [et al.] -- Specialized fluorescence in situ hybridization (FISH) techniques for leukaemia research / L. Kearney and S. Colman -- LDI-PCR: identification of known and unknown gene fusions of the human MLL gene / C. Meyer and R. Marschalek -- Panhandle PCR approaches to cloning MLL genomic breakpoint junctions and fusion transcript sequences / B.W. Robinson and C.A. Felix -- MRD detection in acute lymphoblastic leukemia patients using Ig/TCR gene rearrangements as targets for real-time quantitative PCR / V.H. van der Velden and J.J. van Dongen -- Array-based comparative genomic hybridization as a tool for analyzing the leukemia genome / J.C. Strefford and H. Parker -- Application of SNP genotype arrays to determine somatic changes in cancer / M. Gupta and B.D. Young -- Retroviral/Lentiviral transduction and transformation assay / B.B. Zeisig and C.W. So -- Gene expression profiling of leukemia stem cells / A.V. Krivtsov ... [et al.] -- Humanized model to study leukemic stem cells / D. Bonnet -- Model systems for examining effects of leukemia-associated oncogenes in primary human CD34+ cells via retroviral transduction / M. Wunderlich and J.C. Mulloy -- Ex vivo assays to study self-renewal and long-term expansion of genetically modified primary human acute myeloid leukemia stem cells / J.J. Schuringa and H. Schepers -- Identification and characterization of hematopoietic stem and progenitor cell populations in mouse bone marrow by flow cytometry / J. Yeung and A.C. Wai Eric So -- In vitro differentiation of mouse embryonic stem cells as a model of early hematopoietic development / P. Sroczynska ... [et al.] -- Analysis of the mouse placenta as a hematopoietic stem cell niche / K. Ottersbach and E. Dzierzak -- Identification of protein interaction partners by the yeast two-hybrid system / M.P. Garcia-Cuellar, D. Mederer and R.K. Slany -- Complete array of HOX gene expression by RQ-PCR / G.J. Dickson, T.R. Lappin and A. Thompson -- Genome-wide determination of DNA methylation by Hpa II tiny fragment enrichment by ligation-mediated PCR (HELP) for the study of acute leukemias / M.E. Figueroa, A. Melnick and J.M. Greally -- Chromatin immunoprecipitation (ChIP) for analysis of histone modifications and chromatin-associated proteins / T.A. Milne, K. Zhao and J.L. Hess.
  • 2001From: ScienceDirect
    Hans G. Drexler.
    Also available: Print – 2001
  • Gregory Sean Corrado.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2009From: Ovid
    Elder, David E.; Elenitsas, Rosalie; Lever, Walter F.
    Also available: Print – 2009
  • 2015From: Ovid
    editor in chief, David E. Elder, MD, CHB, FRCPA, Professor of Pathology and Laboratory Medicine, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania ; associate editors, Rosalie Elenitsas, MD, Director of Dermatology, Director of Dermatopathology, Department of Dermatology, Hospital of the University of Pennsylvania, Philadelphia, Pennsylvania, Misha Rosenbach, MD, Assistant Professor of Dermatology & Internal Medicine, Associate Program Director, Dermatology Residency, Director, Dermatology Inpatient Consult Service, Director Cutaneous Sarcidosis Clinic, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, George F. Murphy, MD, Professor of Pathology, Harvard Medical School, Director, Program in Dermatopathology, Department of Pathology, Brigham and Women's Hospital, Boston, Massachusetts, Adam I. Rubin, MD, Assistant Professor of Dermatology, Hospital of the University of Pennsylvania, The Children's Hospital, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, Xiaowei Xu, MD, PhD, Associate Professor, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania.
    "Lever's Histopathology of the Skin, first published in 1949, is a classic work that has been used by dermatopathologists, pathologists, and dermatologists in their own training, in their current practices, and in the training of students. The organization used in the book is based on Walter Lever's original scheme, which is centered on general attributes of the diseases including pathophysiological and etiological considerations"-- Provided by publisher.
  • 2005From: Ovid
    editor-in-chief, David E. Elder ; associate editors, Rosalie Elenitsas ... [et al.].
    Introduction to dermatopathologic diagnosis -- Biopsy techniques -- Histology of the skin -- Laboratory methods -- Algorithmic classification of skin disease for differential diagnosis -- Congenital diseases (genodermatoses) -- Noninfectious erythematous, papular, and squamous diseases -- Vascular diseases -- Noninfectious vesiculobullous and vesiculopustular diseases -- Connective tissue diseases -- Cutaneous toxicities of drugs -- The photosensitivity disorders -- Diseases caused by viruses -- The histiocytoses -- Pigmentary disorders of the skin -- Benign pigmented lesions and malignant melanoma -- Tumors and cysts of the epidermis -- Tumors of the epidermal appendages -- Cutaneous lymphomas and leukemias -- Tumors of fibrous tissue involving the skin -- Vascular tumors: tumors and tumor-like conditions of blood vessles and lymphatics --Tumors with fatty, muscular, osseous, and cartilagenous differentiation -- Tumors of neural tissue -- Metastatic carcinoma of the skin: incidence and dissemination. Disorders associated with physical agents: heat, cold, radiation, and trauma -- Noninfectious granulomas -- Degenerative diseases and perforating disorders -- Cutaneous manifestations of nutritional deficiency states and gastrointestinal disease -- Metabolic diseases of the skin -- Inflammatory diseases of hair follicles, sweat glands, and cartilage -- Inflammatory diseases of the nail -- Inflammatory diseases of the subcutaneous fat -- Bacterial diseases -- Treponemal diseases -- Fungal diseases -- Protozoan diseases and parasitic infestations --
    Also available: Print – 2005
  • 2008From: ClinicalKey
    [edited by] John H. Bowker, Michael A. Pfeifer.
    Fully updated, now in full color, this latest edition of Levin and O'Neal's The Diabetic Foot provides diagnostic and management information for the challenging problems faced by patients with diabetic foot problems. The book has a team care focus and offers tips and pearls in every chapter.
  • 2014From: Springer
    Susan H. Fox, Jonathan M. Brotchie, editors.
    This book aims to provide a single reference source on levodopa-induced dyskinesias (LID) from ?bench to bedside?. Initial chapters review the clinical features and phenomenology of LID with video examples; epidemiology and genetic risk factors for LID are covered as a background to understanding risk factors for developing LID. The following chapters cover the latest preclinical studies aiming to understand the pathophysiology of LID at the cellular, neurochemical, neurophysiological and circuitry level with detailed discussion of mechanisms and future directions to take the field forward; clinical studies from phase II to phase IV; ongoing RCTs in LID; and evidence-based medicine reviews of treatment options. Levodopa-Induced Dyskinesia in Parkinson?s Disease is aimed at an international audience of movement disorder neurologists; neuroscientists; trainees; and graduate and post-graduate students.
  • 2014From: Ovid
    [edited by] Robert Riddell, Dhanpat Jain.
  • [edited by] Jocelyn E. Krebs, Elliott S. Goldstein, Stephen T. Kilpatrick.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007From: Ovid
    editors, Andrés Martin, Fred R. Volkmar, editor emeritus, Melvin Lewis.
  • von Josef Maherhöfer.
    PrintStatus: Not Checked OutLane Catalog Record
  • 2007From: Springer
    edited by Anita H. Payne, Matthew P. Hardy.
  • 2012From: Springer
    Michele K. Lewis, Isiah Marshall.
    Indigenous and intersecting : people of African descent in LGBT psychology -- Gender and Black communities -- Religion and spirituality -- New "outsiders" : Black lesbian, gay, and bisexual students in a historically Black university context -- Black gay men of the South : research implications and E. Patrick Johnson's Sweet tea -- Sexual minority women of African descent -- Cultural complexities and conflict -- Covering, cultural-centrism, and liberation psychology -- Urban and rural challenges -- Education, research, and community services.
  • Luis Alberto Chia.
    The intestinal epithelium is one of the most rapidly proliferating tissues in the body. A complete turnover of the epithelium occurs every 3-5 days in the mouse, a process that is maintained by a small population of intestinal stem cells (ISCs) that reside in the crypt bases. The signals that regulate the behavior of these ISCs are still poorly understood. However, the recent identification of genes that mark functional stem cells has yielded insights into how ISCs are regulated and maintained. Here, we demonstrate that Bmi1 and Lgr5 mark two functionally distinct ISCs in vivo. Lgr5 marks mitotically active ISCs that exhibit exquisite sensitivity to canonical Wnt modulation, contribute robustly to homeostatic regeneration, and are quantitatively ablated by irradiation. In contrast, Bmi1 marks quiescent ISCs that are insensitive to Wnt perturbations, contribute weakly to homeostatic regeneration, and are resistant to high dose radiation injury. Post-irradiation, however, the normally quiescent Bmi1+ ISCs dramatically proliferate to clonally repopulate multiple contiguous crypts and villi. Clonogenic culture of isolated single Bmi1+ ISCs yields long-lived self-renewing spheroids of intestinal epithelium that produce Lgr5-expressing cells, thereby establishing a lineage relationship between these two populations in vitro. Taken together, these data provide direct evidence that Bmi1 marks quiescent, injury-inducible reserve ISCs that exhibit striking functional distinctions from Lgr5+ ISCs, and support a model whereby distinct ISC populations facilitate homeostatic versus injury-induced regeneration. How these ISCs maintain their stemness remains unclear. Paneth cells have been suggested to serve as niche cells for the Lgr5+ ISCs, perhaps through the secretion of essential paracrine factors, but recent reports clearly demonstrate that Paneth cells are not required for Lgr5+ ISC maintenance. Recently, the G-protein-coupled receptors Lgr4-6 were reported to associate with Wnt receptors to mediate R-spondin signaling. Given the importance of Wnt/R-spondin signaling in intestinal crypt maintenance, we tested the in vivo function of Lgr5 by adenovirus-mediated overexpression of the soluble ligand-binding Lgr5 extracellular domain. Circulating Lgr5 ectodomain induced the migration of Paneth cells from the crypts, their eventual loss, and a concomitant disappearance of Lgr5+ ISCs. Paneth cell migration was associated with downregulation of Wnt signaling and its target EphB3. The loss of Lgr5+ ISCs did not affect maintenance of the intestinal epithelium, nor did Lgr5+ stem cells disappear from non-intestinal organs. Together, these findings characterize an easily tractable experimental model for the in vivo deletion of Lgr5+ ISCs, and suggest that Lgr receptors function to actively maintain Lgr5+ ISCs in vivo.
  • 2013Limited to 1 simultaneous usersFrom: ProQuest Ebook Central
    edited by Joseph Janes.
    Thinking about the future of libraries, librarianship and the work librarians do is as old as libraries themselves. (No doubt seminars were organized by the Alexandria Librarians Association on the future of the scroll and what to do about the rising barbarian tide.) At no time in our memory, though, have these discussions and conversations been so profound and critical. Here one of today's leading thinkers and speakers about the future of libraries brings together 30 leaders from all types of libraries and from outside librarianship to describe their vision of what the library will be in 2020. Contributors and Library Journal's The Annoyed Librarian were asked to describe the "library of 2020, "in whatever terms they wanted, either a specific library or situation or libraries in general. They were told: "be bold, be inspirational, be hopeful, be true, be provocative, be realistic, be depressing, be light-hearted, be thoughtful, be fun, be yourself, and for heaven's sake, don't be boring." Not that they could be. Broadly representative of important perspectives and aspects within the profession as well as featuring important voices beyond the professional realm, Library 2020 presents thought-provoking and illuminating visions from many points of view. It is both required reading for library leaders and trustees as well as an ideal supplemental text for LIS classes looking at the future of the profession.

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